TNK2

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
Y Sites Probabilities
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A5A3E0 Y940 Sugiyama POTEF A26C1B ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
A6NEC2 Y173 Sugiyama NPEPPSL1 NDKMKGFYRSKYTTPSGEVRyAAVTQFEATDARRAFPCWDE
A6NHL2 Y319 Sugiyama TUBAL3 TTACFESSNQLVKCDPRLGKyMACCLLyRGDVVPKEVNAAI
A6NMY6 Y333 Sugiyama ANXA2P2 ANX2L2 ANX2P2 LPC2B KsLyyyIQQDTKGDyQKALLyLCGGDD______________
O00115 Y53 Sugiyama DNASE2 DNASE2A DNL2 YKLPALRGSGEAAQRGLQYKyLDEssGGWRDGRALINsPEG
O00115 Y83 Sugiyama DNASE2 DNASE2A DNL2 DGRALINsPEGAVGRSLQPLyRSNTSQLAFLLYNDQPPQPS
O00170 Y203 Sugiyama AIP XAP2 HQEGNRLYREGHVKEAAAKyyDAIACLKNLQMKEQPGSPEW
O00233 Y41 Sugiyama PSMD9 SDVQELMRRKEEIEAQIKANyDVLEsQKGIGMNEPLVDCEG
O00299 Y233 Sugiyama CLIC1 G6 NCC27 AyAREEFAstCPDDEEIELAyEQVAKALK____________
O00401 S242 EPSD WASL GFDLNNLDPELKNLFDMCGIsEAQLKDRETSKVIyDFIEKT
O00401 Y256 EPSD|Sugiyama WASL FDMCGIsEAQLKDRETSKVIyDFIEKTGGVEAVKNELRRQA
O00429 Y101 Sugiyama DNM1L DLP1 DRP1 EENGVEAEEWGKFLHTKNKLyTDFDEIRQEIENETERISGN
O00625 Y131 Sugiyama PIR AHGLQLWVNLRSSEKMVEPQyQELKSEEIPKPSKDGVTVAV
O14818 Y145 Sugiyama PSMA7 HSPC RPFGISALIVGFDFDGTPRLyQtDPsGtyHAWKANAIGRGA
O14818 Y153 Sugiyama PSMA7 HSPC IVGFDFDGTPRLyQtDPsGtyHAWKANAIGRGAKSVREFLE
O14828 Y35 Sugiyama SCAMP3 C1orf3 PROPIN1 sELDNPFQDPAVIQHRPsRQyATLDVyNPFETREPPPAyEP
O14950 Y143 Sugiyama MYL12B MRLC2 MYLC2B LRELLttMGDRFtDEEVDELyREAPIDKKGNFNyIEFtRIL
O14950 Y156 Sugiyama MYL12B MRLC2 MYLC2B DEEVDELyREAPIDKKGNFNyIEFtRILKHGAKDKDD____
O14974 Y446 Sugiyama PPP1R12A MBS MYPT1 EERKDEsPATWRLGLRKtGsyGALAEItASKEGQKEKDTAG
O14974 Y901 Sugiyama PPP1R12A MBS MYPT1 EtQtDsIsRyETssTsAGDRyDsLLGRsGsysYLEERKPYS
O15230 Y81 Sugiyama LAMA5 KIAA0533 KIAA1907 SATCGEEAPARGSPRPTEDLyCKLVGGPVAGGDPNQTIRGQ
O15234 Y263 Sugiyama CASC3 MLN51 DIRSAHNPDDIKPRRIRKPRyGsPPQRDPNWNGERLNKSHR
O43143 Y254 Sugiyama DHX15 DBP1 DDX15 KYMTDGMLLREAMNDPLLERyGVIILDEAHERTLATDILMG
O43164 Y63 Sugiyama PJA2 KIAA0438 RNF131 VSFKPCMTRHERSLGRAGDDyEVLELDDVPKENssGssPLD
O43390 Y376 Sugiyama HNRNPR HNRPR ILEKSFSEFGKLERVKKLKDyAFVHFEDRGAAVKAMDEMNG
O43464 Y147 Sugiyama HTRA2 OMI PRSS25 GPPAVLAAVPSPPPAsPRSQyNFIADVVEKTAPAVVYIEIL
O43707 Y212 Sugiyama ACTN4 WKDGLAFNALIHRHRPELIEyDKLRKDDPVTNLNNAFEVAE
O43707 Y234 Sugiyama ACTN4 KLRKDDPVTNLNNAFEVAEKyLDIPKMLDAEDIVNtARPDE
O43707 Y906 Sugiyama ACTN4 yQGPDAVPGALDyKsFStALyGEsDL_______________
O43823 Y311 Sugiyama AKAP8 AKAP95 RGFDRFGPDGTGRKRKQFQLyEEPDtKLARVDsEGDFsEND
O43852 Y106 Sugiyama CALU GFVtVDELKDWIKFAQKRWIyEDVERQWKGHDLNEDGLVsW
O43852 Y263 Sugiyama CALU KNRDGKMDKEEtKDWILPsDyDHAEAEARHLVyEsDQNKDG
O60245 Y180 Sugiyama PCDH7 BHPCDH TLYLLPTATDRDFGRNGIERyELLQEPGGGGSGGESRRAGA
O60361 Y136 Sugiyama NME2P1 SLRFKPEELVDYKSCAHDWVyE___________________
O60493 Y71 Sugiyama SNX3 IRVKTNLPIFKLKESTVRRRysDFEWLRSELERESKVVVPP
O60547 Y159 Sugiyama GMDS VKTCGLINSVKFYQASTSELyGKVQEIPQKETtPFYPRSPY
O60716 Y228 Sugiyama CTNND1 KIAA0384 yPPDGysRHyEDGyPGGsDNyGsLsRVtRIEERyRPsMEGy
O60814 Y43 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK QKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMGIM
O75347 Y75 Sugiyama TBCA EILQEsRMMIPDCQRRLEAAyLDLQRILENEKDLEEAEEyK
O75688 Y367 Sugiyama PPM1B PP2CB IPNLPPGGGLAGKRNVIEAVySRLNPHREsDGAsDEAEEsG
O94906 Y105 Sugiyama PRPF6 C20orf14 AGSLFSSGPYEKDDEEADAIyAALDKRMDERRKERREQREK
O95425 Y120 Sugiyama SVIL SKAERIARYKAERRRQLAEKyGLTLDPEADsEyLsRYTKSR
O95714 S2928 Sugiyama HERC2 ILLGRIRAEEEDLAAVPFLAsDNEEEEDEKGNSGsLIRKKA
O95817 Y247 Sugiyama BAG3 BIS QAQKTHyPAQQGEyQtHQPVyHKIQGDDWEPRPLRAAsPFR
O95881 Y137 Sugiyama TXNDC12 TLP19 UNQ713/PRO1376 FLDPSGKVHPEIINENGNPsyKyFyVsAEQVVQGMKEAQER
P00338 Y10 Sugiyama LDHA PIG19 ___________MAtLKDQLIyNLLKEEQtPQNKITVVGVGA
P00338 Y239 Sugiyama LDHA PIG19 GtDKDKEQWKEVHKQVVEsAyEVIKLKGYtSWAIGLSVADL
P00558 Y161 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 KAEPAKIEAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNL
P00966 Y207 Sugiyama ASS1 ASS HIsyEAGILENPKNQAPPGLytKtQDPAKAPNtPDILEIEF
P02786 Y402 Sugiyama TFRC KEIKILNIFGVIKGFVEPDHyVVVGAQRDAWGPGAAKSGVG
P04406 Y314 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 tFDAGAGIALNDHFVKLIsWyDNEFGysNRVVDLMAHMAsK
P04632 Y87 Sugiyama CAPNS1 CAPN4 CAPNS sAISEAAAQYNPEPPPPRtHysNIEANEsEEVRQFRRLFAQ
P05387 Y7 Sugiyama RPLP2 D11S2243E RPP2 ______________MRyVAsyLLAALGGNssPsAKDIKKIL
P05787 Y286 Sugiyama KRT8 CYK8 QyEDIANRsRAEAEsMyQIKyEELQsLAGKHGDDLRRTKTE
P06733 Y270 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 EFFRsGKyDLDFKsPDDPsRyIsPDQLADLyKsFIKDyPVV
P06733 Y280 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 DFKsPDDPsRyIsPDQLADLyKsFIKDyPVVsIEDPFDQDD
P06733 Y407 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GLCtGQIKTGAPCRSERLAKyNQLLRIEEELGsKAKFAGRN
P06733 Y44 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P07205 Y161 Sugiyama PGK2 PGKB KAEPDKIEAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNL
P07237 Y94 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB GSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNGDTASPK
P07355 Y188 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D RKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVKRKGT
P07355 Y333 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D KsLyyyIQQDTKGDyQKALLyLCGGDD______________
P07737 Y129 Sugiyama PFN1 tLVLLMGKEGVHGGLINKKCyEMAsHLRRsQY_________
P07814 Y1504 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 KPLCELQPGAKCVCGKNPAKyytLFGRsy____________
P07814 Y1505 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 PLCELQPGAKCVCGKNPAKyytLFGRsy_____________
P07814 Y827 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 EIGQNIssNssAsILESKsLyDEVAAQGEVVRKLKAEKSPK
P07900 Y284 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DEEEEKKDGDKKKKKKIKEKyIDQEELNKtKPIWtRNPDDI
P07900 Y313 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA tKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEG
P07900 Y492 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DEMVsLKDYCTRMKENQKHIyyItGETKDQVANsAFVERLR
P07900 Y61 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA KEIFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLI
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 Y276 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DEEDDsGKDKKKKTKKIKEKyIDQEELNKtKPIWtRNPDDI
P08238 Y305 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB tKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEG
P08238 Y457 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB LKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMK
P08238 Y484 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DEMtsLsEyVsRMKEtQKsIyyItGEsKEQVANsAFVERVR
P08238 Y56 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB KEIFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDII
P08670 Y53 Sugiyama VIM tsTRtYsLGsALRPstsRsLyAssPGGVyAtRssAVRLRss
P08708 Y84 Sugiyama RPS17 RPS17L GPVRGISIKLQEEERERRDNyVPEVsALDQEIIEVDPDtKE
P08865 Y156 Sugiyama RPSA LAMBR LAMR1 EAsyVNLPtIALCNTDSPLRyVDIAIPCNNKGAHSVGLMWW
P09104 T41 Sugiyama ENO2 EVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRYLGKG
P09104 Y44 Sugiyama ENO2 LyTAKGLFRAAVPsGAstGIyEALELRDGDKQRYLGKGVLK
P09211 Y50 Sugiyama GSTP1 FAEES3 GST3 KEEVVTVETWQEGsLKASCLyGQLPKFQDGDLtLyQsNtIL
P10275 Y269 EPSD|PSP AR DHTR NR3C4 LGVEALEHLsPGEQLRGDCMyAPLLGVPPAVRPtPCAPLAE
P10275 Y365 EPSD|PSP AR DHTR NR3C4 LSLYKSGALDEAAAYQSRDYyNFPLALAGPPPPPPPPHPHA
P10275 Y535 PSP AR DHTR NR3C4 PsPTCVKSEMGPWMDSYSGPyGDMRLETARDHVLPIDYYFP
P10398 Y155 Sugiyama ARAF ARAF1 PKS PKS2 HCSSKVPTVCVDMSTNRQQFyHsVQDLsGGsRQHEAPsNRP
P10809 Y243 Sugiyama HSPD1 HSP60 yIsPyFINtsKGQKCEFQDAyVLLsEKKIssIQsIVPALEI
P11142 Y41 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P11940 Y291 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 ERQTELKRKFEQMKQDRITRyQGVNLyVKNLDDGIDDERLR
P12814 Y215 Sugiyama ACTN1 KLRKDDPLTNLNTAFDVAEKyLDIPKMLDAEDIVGtARPDE
P12814 Y842 Sugiyama ACTN1 DTDTADQVMASFKILAGDKNyITMDELRRELPPDQAEyCIA
P13010 Y316 Sugiyama XRCC5 G22P2 CLNDDDETEVLKEDIIQGFRyGsDIVPFSKVDEEQMKYKSE
P13639 Y634 Sugiyama EEF2 EF2 AEDIDKGEVsARQELKQRARyLAEKyEWDVAEARKIWCFGP
P13639 Y639 Sugiyama EEF2 EF2 KGEVsARQELKQRARyLAEKyEWDVAEARKIWCFGPDGTGP
P13639 Y730 Sugiyama EEF2 EF2 HADAIHRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQ
P13667 Y273 Sugiyama PDIA4 ERP70 ERP72 PTLKIFRKGRPYDYNGPREKyGIVDyMIEQSGPPSKEILTL
P13796 Y124 Sugiyama LCP1 PLS2 GGtsEQssVGtQHsysEEEKyAFVNWINKALENDPDCRHVI
P13797 Y127 Sugiyama PLS3 GGTsELssEGtQHsysEEEKyAFVNWINKALENDPDCRHVI
P13929 T41 Sugiyama ENO3 EVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRYLGKG
P13929 Y44 Sugiyama ENO3 LHtAKGRFRAAVPsGAstGIyEALELRDGDKGRYLGKGVLK
P14314 T469 Sugiyama PRKCSH G19P1 WGsWIGPDHDKFSAMKyEQGtGCWQGPNRstTVRLLCGKEt
P14324 Y349 Sugiyama FDPS FPS KIAA1293 QDNKCSWLVVQCLQRATPEQyQILKENYGQKEAEKVARVKA
P14625 Y539 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 tDItsLDQyVERMKEKQDKIyFMAGsSRKEAEssPFVERLL
P14649 S87 Sugiyama MYL6B MLC1SA EEFKEAFELFDRVGDGKILysQCGDVMRALGQNPtNAEVLK
P14649 Y86 Sugiyama MYL6B MLC1SA LEEFKEAFELFDRVGDGKILysQCGDVMRALGQNPtNAEVL
P14854 Y57 Sugiyama COX6B1 COX6B FHRCQKAMTAKGGDIsVCEWyQRVYQsLCPtsWVTDWDEQR
P15259 Y92 Sugiyama PGAM2 PGAMM DGTDQMWLPVVRTWRLNERHyGGLtGLNKAETAAKHGEEQV
P15880 Y248 Sugiyama RPS2 RPS4 GCtAtLGNFAKATFDAISKTysyLtPDLWKEtVFtKsPyQE
P15880 Y250 Sugiyama RPS2 RPS4 tAtLGNFAKATFDAISKTysyLtPDLWKEtVFtKsPyQEFt
P16070 Y79 Sugiyama CD44 LHR MDU2 MDU3 MIC4 TLPTMAQMEKALsIGFEtCRyGFIEGHVVIPRIHPNSICAA
P17066 Y43 Sugiyama HSPA6 HSP70B' FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P17676 Y137 Sugiyama CEBPB TCF5 PP9092 FLSDLFSDDYGGKNCKKPAEyGyVsLGRLGAAKGALHPGCF
P17676 Y139 Sugiyama CEBPB TCF5 PP9092 SDLFSDDYGGKNCKKPAEyGyVsLGRLGAAKGALHPGCFAP
P17812 Y468 Sugiyama CTPS1 CTPS MRLGKRRtLFQTKNsVMRKLyGDADyLEERHRHRFEVNPVW
P17980 Y185 Sugiyama PSMC3 TBP1 PtEyDsRVKAMEVDERPtEQysDIGGLDKQIQELVEAIVLP
P17980 Y381 Sugiyama PSMC3 TBP1 ARARIMQIHSRKMNVsPDVNyEELARCTDDFNGAQCKAVCV
P18206 Y822 Sugiyama VCL KAVAGNIsDPGLQKsFLDsGyRILGAVAKVREAFQPQEPDF
P18615 Y133 Sugiyama NELFE RD RDBP sIsADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEA
P18615 Y367 Sugiyama NELFE RD RDBP SLAVQNsPKGCHRDKRTQIVysDDVyKENLVDGF_______
P18669 S137 Sugiyama PGAM1 PGAMA CDABP0006 RsyDVPPPPMEPDHPFysNIsKDRRyADLtEDQLPsCEsLK
P18669 Y119 Sugiyama PGAM1 PGAMA CDABP0006 NKAETAAKHGEAQVKIWRRsyDVPPPPMEPDHPFysNIsKD
P18669 Y142 Sugiyama PGAM1 PGAMA CDABP0006 PPPPMEPDHPFysNIsKDRRyADLtEDQLPsCEsLKDtIAR
P18669 Y92 Sugiyama PGAM1 PGAMA CDABP0006 DAIDQMWLPVVRTWRLNERHyGGLtGLNKAETAAKHGEAQV
P19105 Y142 Sugiyama MYL12A MLCB MRLC3 RLC LRELLttMGDRFtDEEVDELyREAPIDKKGNFNyIEFtRIL
P19105 Y155 Sugiyama MYL12A MLCB MRLC3 RLC DEEVDELyREAPIDKKGNFNyIEFtRILKHGAKDKDD____
P19338 Y462 Sugiyama NCL AEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNSTWs
P20618 Y150 Sugiyama PSMB1 PSC5 FPYYVYNIIGGLDEEGKGAVysFDPVGsyQRDsFKAGGSAS
P20674 Y80 Sugiyama COX5A FNKPDIDAWELRKGINTLVTyDMVPEPKIIDAALRACRRLN
P22234 Y22 Sugiyama PAICS ADE2 AIRC PAIS AtAEVLNIGKKLYEGKtKEVyELLDsPGKVLLQsKDQItAG
P22314 Y451 Sugiyama UBA1 A1S9T UBE1 CLPEDKEVLTEDKCLQRQNRyDGQVAVFGsDLQEKLGKQKY
P22314 Y55 Sugiyama UBA1 A1S9T UBE1 SVPTNGMAKNGsEADIDEGLysRQLyVLGHEAMKRLQTSSV
P22392 Y151 Sugiyama NME2 NM23B SLWFKPEELVDyKSCAHDWVyE___________________
P22626 Y336 Sugiyama HNRNPA2B1 HNRPA2B1 MKsGNFGGsRNMGGPyGGGNyGPGGsGGsGGyGGRsRy___
P23434 Y139 Sugiyama GCSH EVTEINEALAENPGLVNKSCyEDGWLIKMtLsNPsELDELM
P23470 Y92 Sugiyama PTPRG PTPG VTSSVSCGGRHQSPIDILDQyARVGEEYQELQLDGFDNESS
P23528 Y140 Sugiyama CFL1 CFL SKDAIKKKLtGIKHELQANCyEEVKDRCTLAEKLGGsAVIs
P23528 Y68 Sugiyama CFL1 CFL ILEEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyALyDAt
P23528 Y82 Sugiyama CFL1 CFL QtVDDPyAtFVKMLPDKDCRyALyDAtyEtKESKKEDLVFI
P23528 Y85 Sugiyama CFL1 CFL DDPyAtFVKMLPDKDCRyALyDAtyEtKESKKEDLVFIFWA
P23588 Y593 Sugiyama EIF4B APEPKKPEENPASKFssASKyAALsVDGEDENEGEDyAE__
P24752 Y90 Sugiyama ACAT1 ACAT MAT IAIQGAIEKAGIPKEEVKEAyMGNVLQGGEGQAPTRQAVLG
P25205 Y708 Sugiyama MCM3 KRKRRKTRQPDAKDGDsyDPyDFsDtEEEMPQVHtPKTADs
P25208 Y58 Sugiyama NFYB HAP3 SMNDHEDTNGSKESFREQDIyLPIANVARIMKNAIPQTGKI
P25685 Y52 Sugiyama DNAJB1 DNAJ1 HDJ1 HSPF1 HPDKNKEPGAEEKFKEIAEAyDVLSDPRKREIFDRYGEEGL
P25685 Y6 Sugiyama DNAJB1 DNAJ1 HDJ1 HSPF1 _______________MGKDyyQTLGLARGAsDEEIKRAYRR
P25705 Y243 PSP ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM IDtIINQKRFNDGsDEKKKLyCIyVAIGQKRsTVAQLVKRL
P25705 Y246 PSP ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM IINQKRFNDGsDEKKKLyCIyVAIGQKRsTVAQLVKRLTDA
P25786 Y6 Sugiyama PSMA1 HC2 NU PROS30 PSC2 _______________MFRNQyDNDVtVWsPQGRIHQIEYAM
P26599 Y127 Sugiyama PTBP1 PTB ANTMVNYYTSVTPVLRGQPIyIQFsNHKELKtDSSPNQARA
P27348 Y149 Sugiyama YWHAQ LAEVACGDDRKQtIDNsQGAyQEAFDIsKKEMQPTHPIRLG
P27348 Y19 Sugiyama YWHAQ __MEKTELIQKAKLAEQAERyDDMAtCMKAVtEQGAELsNE
P27348 Y48 Sugiyama YWHAQ AVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSIEQK
P27695 Y128 Sugiyama APEX1 APE APE1 APEX APX HAP1 REF1 LQELPGLSHQYWSAPsDKEGysGVGLLsRQCPLKVsyGIGD
P27695 Y45 Sugiyama APEX1 APE APE1 APEX APX HAP1 REF1 KSKTAAKKNDKEAAGEGPALyEDPPDQKtsPsGKPAtLKIC
P27816 Y47 Sugiyama MAP4 AtLEAEAFDDVVGETVGKTDyIPLLDVDEKtGNsESKKKPC
P29353 Y427 Sugiyama SHC1 SHC SHCA RKQMPPPPPCPGRELFDDPsyVNVQNLDKARQAVGGAGPPN
P29401 Y481 Sugiyama TKT AANTKGICFIRTsRPENAIIyNNNEDFQVGQAKVVLKSKDD
P29692 Y26 Sugiyama EEF1D EF1D LAHEKIWFDKFKYDDAERRFyEQMNGPVAGAsRQENGAsVI
P30043 Y205 Sugiyama BLVRB FLR SCAN MLRCLttDEyDGHstyPsHQyQ___________________
P30085 Y27 Sugiyama CMPK1 CMK CMPK UCK UMK UMPK FVLGGPGAGKGTQCARIVEKyGytHLSAGELLRDERKNPDs
P30085 Y49 Sugiyama CMPK1 CMK CMPK UCK UMK UMPK ytHLSAGELLRDERKNPDsQyGELIEKYIKEGKIVPVEITI
P30086 T65 Sugiyama PEBP1 PBP PEBP QVKNRPtsIsWDGLDsGKLytLVLtDPDAPsRKDPKYREWH
P30086 Y120 Sugiyama PEBP1 PBP PEBP GtVLsDyVGsGPPKGtGLHRyVWLVyEQDRPLKCDEPILsN
P30086 Y64 Sugiyama PEBP1 PBP PEBP tQVKNRPtsIsWDGLDsGKLytLVLtDPDAPsRKDPKYREW
P30101 Y67 Sugiyama PDIA3 ERP57 ERP60 GRP58 LMLVEFFAPWCGHCKRLAPEyEAAAtRLKGIVPLAKVDCTA
P30101 Y95 Sugiyama PDIA3 ERP57 ERP60 GRP58 KGIVPLAKVDCTANTNTCNKyGVsGyPtLKIFRDGEEAGAy
P30622 Y108 Sugiyama CLIP1 CYLN1 RSN AGIVLDEPIGKNDGSVAGVRyFQCEPLKGIFTRPSKLTRKV
P31749 Y176 SIGNOR|EPSD AKT1 PKB RAC LGKGTFGKVILVKEKATGRYyAMKILKKEVIVAKDEVAHtL
P31943 Y266 Sugiyama HNRNPH1 HNRPH HNRPH1 yNGYNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGstFQst
P31946 Y151 Sugiyama YWHAB LsEVAsGDNKQTtVsNsQQAyQEAFEIsKKEMQPTHPIRLG
P31946 Y50 Sugiyama YWHAB AVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSIEQK
P31947 Y151 Sugiyama SFN HME1 LAEVATGDDKKRIIDSARsAyQEAMDISKKEMPPTNPIRLG
P31947 Y48 Sugiyama SFN HME1 GAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsIEQK
P31948 Y354 Sugiyama STIP1 DVLKKCQQAEKILKEQERLAyINPDLALEEKNKGNECFQKG
P32119 Y115 Sugiyama PRDX2 NKEFB TDPX1 GLGPLNIPLLADVTRRLsEDyGVLKTDEGIAYRGLFIIDGK
P32969 Y180 Sugiyama RPL9 OK/SW-cl.103; RPL9P7; RPL9P8; RPL9P9 LIQQATTVKNKDIRKFLDGIyVsEKGtVQQADE________
P33121 Y693 Sugiyama ACSL1 FACL1 FACL2 LACS LACS1 LACS2 TMKAKRPELRNYFRSQIDDLyStIKV_______________
P33316 Y167 Sugiyama DUT PPMEKAVVKTDIQIALPsGCyGRVAPRSGLAAKHFIDVGAG
P33991 Y394 Sugiyama MCM4 CDC21 AHNDLVDKVQPGDRVNVTGIyRAVPIRVNPRVSNVKSVYKT
P34931 Y43 Sugiyama HSPA1L FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P36871 Y157 Sugiyama PGM1 GPAPEAITDKIFQISKTIEEyAVCPDLKVDLGVLGKQQFDL
P37802 Y192 Sugiyama TAGLN2 KIAA0120 CDABP0035 NVIGLQMGtNRGAsQAGMtGyGMPRQIL_____________
P37837 Y206 Sugiyama TALDO1 TAL TALDO TALDOR ISPFVGRILDWHVANTDKKSyEPLEDPGVKSVTKIYNYYKK
P38117 Y192 Sugiyama ETFB FP585 tLRLKLPAVVTADLRLNEPRyAtLPNIMKAKKKKIEVIKPG
P39019 Y48 Sugiyama RPS19 LKVPEWVDtVKLAKHKELAPyDENWFytRAAstARHLYLRG
P40429 Y149 Sugiyama RPL13A LKPTRKFAYLGRLAHEVGWKyQAVtAtLEEKRKEKAKIHYR
P40925 Y210 Sugiyama MDH1 MDHA tQYPDVNHAKVKLQGKEVGVyEALKDDsWLKGEFVttVQQR
P42768 Y291 EPSD|PSP WAS IMD2 FSRAGIsEAQLtDAETsKLIyDFIEDQGGLEAVRQEMRRQE
P43243 Y214 Sugiyama MATR3 KIAA0723 PsLNPVLDyDHGsRsQEsGyyDRMDyEDDRLRDGERCRDDs
P46778 Y30 Sugiyama RPL21 GTRYMFSRPFRKHGVVPLAtyMRIYKKGDIVDIKGMGTVQK
P46940 Y1478 Sugiyama IQGAP1 KIAA0051 KIQTGLKKLTELGtVDPKNKyQELINDIARDIRNQRRYRQR
P47224 Y114 Sugiyama RABIF MSS4 RASGRF3 CADCEIGPIGWHCLDDKNSFyVALERVSHE___________
P48741 Y43 Sugiyama HSPA7 HSP70B FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P49321 Y540 Sugiyama NASP DMLDLAKIIFKRQETKEAQLyAAQAHLKLGEVSVESENYVQ
P49327 S2032 Sugiyama FASN FAS ELDYFVVFSSVSCGRGNAGQsNyGFANsAMERICEKRRHEG
P49327 Y45 Sugiyama FASN FAS NLIGGVDMVTDDDRRWKAGLyGLPRRsGKLKDLSRFDAsFF
P49588 Y192 Sugiyama AARS1 AARS KDNFWEMGDtGPCGPCsEIHyDRIGGRDAAHLVNQDDPNVL
P50402 Y161 Sugiyama EMD EDMD STA sssEEECKDRERPMYGRDsAyQsItHyRPVsAsRssLDLsy
P50402 Y167 Sugiyama EMD EDMD STA CKDRERPMYGRDsAyQsItHyRPVsAsRssLDLsyyPTSSS
P50990 Y30 Sugiyama CCT8 C21orf112 CCTQ KIAA0002 GFAQMLKEGAKHFsGLEEAVyRNIQACKELAQTTRTAYGPN
P51692 T684 Sugiyama STAT5B NYLIYVFPDRPKDEVySKyytPVPCESATAKAVDGyVKPQI
P51692 Y683 Sugiyama STAT5B LNYLIYVFPDRPKDEVySKyytPVPCESATAKAVDGyVKPQ
P51812 S708 Sugiyama RPS6KA3 ISPK1 MAPKAPK1B RSK2 YQLNRQDAPHLVKGAMAAtysALNRNQsPVLEPVGRsTLAQ
P51812 Y707 Sugiyama RPS6KA3 ISPK1 MAPKAPK1B RSK2 QYQLNRQDAPHLVKGAMAAtysALNRNQsPVLEPVGRsTLA
P52272 Y681 Sugiyama HNRNPM HNRPM NAGR1 PFDFTWKMLKDKFNECGHVLyADIKMENGKSKGCGVVKFEs
P52565 Y156 Sugiyama ARHGDIA GDIA1 GVKIDKtDyMVGsYGPRAEEyEFLtPVEEAPKGMLARGsYs
P52597 Y82 Sugiyama HNRNPF HNRPF GsEDDVKMALKKDRESMGHRyIEVFKSHRTEMDWVLKHsGP
P54105 Y38 Sugiyama CLNS1A CLCI ICLN RQQPDTEAVLNGKGLGtGtLyIAEsRLSWLDGsGLGFSLEY
P54577 Y289 Sugiyama YARS1 YARS FPLKSEFVILRDEKWGGNKTytAyVDLEKDFAAEVVHPGDL
P54652 Y42 Sugiyama HSPA2 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P55196 Y1497 Sugiyama AFDN AF6 MLLT4 VIRELQPQQQPRTIERRDLQyItVsKEELssGDsLsPDPWK
P55209 Y106 Sugiyama NAP1L1 NRP VKCAQIEAKFyEEVHDLERKyAVLyQPLFDKRFEIINAIYE
P55209 Y110 Sugiyama NAP1L1 NRP QIEAKFyEEVHDLERKyAVLyQPLFDKRFEIINAIYEPTEE
P55327 Y136 Sugiyama TPD52 LQELKQNIAKGWQDVTATSAyKKTSETLSQAGQKASAAFSS
P55786 Y173 Sugiyama NPEPPS PSA NDKMKGFYRSKYTTPSGEVRyAAVTQFEATDARRAFPCWDE
P55795 Y266 Sugiyama HNRNPH2 FTP3 HNRPH2 YGGYNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGssFQst
P55884 Y306 Sugiyama EIF3B EIF3S9 PFKDLGNLRYWLEEAECRDQysVIFESGDRTSIFWNDVKDP
P56945 Y12 Sugiyama BCAR1 CAS CASS1 CRKAS _________MNHLNVLAKALyDNVAEsPDELSFRKGDIMTV
P57053 Y43 Sugiyama H2BC12L H2BFS H2BS1 QKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMGIM
P58876 Y43 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD QKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMGIM
P60174 Y209 Sugiyama TPI1 TPI LRGWLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDG
P60660 S30 Sugiyama MYL6 AEFKEAFQLFDRtGDGKILysQCGDVMRALGQNPtNAEVLK
P60660 Y29 Sugiyama MYL6 TAEFKEAFQLFDRtGDGKILysQCGDVMRALGQNPtNAEVL
P60660 Y89 Sugiyama MYL6 HFLPMLQTVAKNKDQGtyEDyVEGLRVFDKEGNGtVMGAEI
P60709 T297 Sugiyama ACTB TTFNSIMKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEI
P60709 Y198 Sugiyama ACTB LDLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCy
P60709 Y240 Sugiyama ACTB ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P60709 Y294 Sugiyama ACTB IHETTFNSIMKCDVDIRKDLyANtVLsGGttMyPGIADRMQ
P60842 Y197 Sugiyama EIF4A1 DDX2A EIF4A KMFVLDEADEMLsRGFKDQIyDIFQKLNsNtQVVLLSATMP
P60842 Y70 Sugiyama EIF4A1 DDX2A EIF4A yGFEKPsAIQQRAILPCIKGyDVIAQAQsGtGKTATFAISI
P60900 Y160 Sugiyama PSMA6 PROS27 LIGIDEEQGPQVYKCDPAGyyCGFKATAAGVKQtEstsFLE
P61024 Y12 Sugiyama CKS1B CKS1 PNAS-143 PNAS-16 _________MSHKQIyysDKyDDEEFEyRHVMLPKDIAKLV
P61158 S232 Sugiyama ACTR3 ARP3 EVGIPPEQSLETAKAVKERysyVCPDLVKEFNKYDTDGSKW
P61247 Y256 Sugiyama RPS3A FTE1 MFTL sssGKAtGDEtGAKVERADGyEPPVQEsV____________
P61353 Y77 Sugiyama RPL27 MGKKKIAKRSKIKSFVKVyNyNHLMPtRysVDIPLDKtVVN
P61353 Y85 Sugiyama RPL27 RSKIKSFVKVyNyNHLMPtRysVDIPLDKtVVNKDVFRDPA
P61604 Y100 Sugiyama HSPE1 KVVLDDKDyFLFRDGDILGKyVD__________________
P61981 Y49 Sugiyama YWHAG NVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSIEQK
P62081 Y177 Sugiyama RPS7 HLDKAQQNNVEHKVEtFsGVyKKLTGKDVNFEFPEFQL___
P62191 Y184 Sugiyama PSMC1 MDDTDPLVTVMKVEKAPQETyADIGGLDNQIQEIKESVELP
P62249 Y115 Sugiyama RPS16 YYQKYVDEASKKEIKDILIQyDRtLLVADPRRCESKKFGGP
P62258 Y152 Sugiyama YWHAE LAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHPIRLG
P62258 Y49 Sugiyama YWHAE KVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssIEQK
P62269 S96 Sugiyama RPS18 D6S218E QYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLKK
P62269 Y95 Sugiyama RPS18 D6S218E RQYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLK
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62736 Y242 Sugiyama ACTA2 ACTSA ACTVS GIG46 ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62750 Y144 Sugiyama RPL23A VNtLIRPDGEKKAYVRLAPDyDALDVANKIGII________
P62750 Y74 Sugiyama RPL23A LRRQPKYPRKSAPRRNKLDHyAIIKFPLTTEsAMKKIEDNN
P62805 Y89 EPSD H4C1 H4/A H4FA HIST1H4A; H4C2 H4/I H4FI HIST1H4B; H4C3 H4/G H4FG HIST1H4C; H4C4 H4/B H4FB HIST1H4D; H4C5 H4/J H4FJ HIST1H4E; H4C6 H4/C H4FC HIST1H4F; H4C8 H4/H H4FH HIST1H4H; H4C9 H4/M H4FM HIST1H4I; H4C11 H4/E H4FE HIST1H4J; H4C12 H4/D H4FD HIST1H4K; H4C13 H4/K H4FK HIST1H4L; H4C14 H4/N H4F2 H4FN HIST2H4 HIST2H4A; H4C15 H4/O H4FO HIST2H4B; H4C16 H4-16 HIST4H4 DAVtyTEHAKRKtVTAMDVVyALKRQGRTLYGFGG______
P62807 Y43 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI QKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKAMGIM
P62826 Y146 Sugiyama RAN ARA24 OK/SW-cl.81 IKDRKVKAKsIVFHRKKNLQyyDIsAKSNyNFEKPFLWLAR
P62826 Y147 Sugiyama RAN ARA24 OK/SW-cl.81 KDRKVKAKsIVFHRKKNLQyyDIsAKSNyNFEKPFLWLARK
P62906 Y11 Sugiyama RPL10A NEDD6 __________MSSKVsRDtLyEAVREVLHGNQRKRRKFLET
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62942 Y27 Sugiyama FKBP1A FKBP1 FKBP12 tIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRDRNKPF
P63104 Y149 Sugiyama YWHAZ LAEVAAGDDKKGIVDQsQQAyQEAFEIsKKEMQPTHPIRLG
P63104 Y19 Sugiyama YWHAZ __MDKNELVQKAKLAEQAERyDDMAACMKsVtEQGAELsNE
P63104 Y48 Sugiyama YWHAZ sVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssIEQK
P63173 Y41 Sugiyama RPL38 KSVKIKKNKDNVKFKVRCSRyLytLVItDKEKAEKLKQSLP
P63173 Y43 Sugiyama RPL38 VKIKKNKDNVKFKVRCSRyLytLVItDKEKAEKLKQSLPPG
P63220 T52 Sugiyama RPS21 IQMNVAEVDKVTGRFNGQFKtyAICGAIRRMGEsDDsILRL
P63261 T297 Sugiyama ACTG1 ACTG TTFNSIMKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEI
P63261 Y198 Sugiyama ACTG1 ACTG LDLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCy
P63261 Y240 Sugiyama ACTG1 ACTG ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63261 Y294 Sugiyama ACTG1 ACTG IHETTFNSIMKCDVDIRKDLyANtVLsGGttMyPGIADRMQ
P63267 Y241 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P67809 Y208 Sugiyama YBX1 NSEP1 YB1 yRRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGE
P67809 Y72 Sugiyama YBX1 NSEP1 YB1 KKVIATKVLGTVKWFNVRNGyGFINRNDtKEDVFVHQtAIK
P68032 Y242 Sugiyama ACTC1 ACTC ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68104 Y29 Sugiyama EEF1A1 EEF1A EF1A LENG7 NIVVIGHVDsGKstttGHLIyKCGGIDKRTIEKFEKEAAEM
P68104 Y86 Sugiyama EEF1A1 EEF1A EF1A LENG7 ERERGITIDISLWKFEtsKyyVtIIDAPGHRDFIKNMITGT
P68133 Y242 Sugiyama ACTA1 ACTA ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68363 Y312 Sugiyama TUBA1B tNACFEPANQMVKCDPRHGKyMACCLLyRGDVVPKDVNAAI
P68366 Y312 Sugiyama TUBA4A TUBA1 tNACFEPANQMVKCDPRHGKyMACCLLyRGDVVPKDVNAAI
P78318 Y277 Sugiyama IGBP1 IBP1 AGYPSLPTMTVSDWYEQHRKyGALPDQGIAKAAPEEFRKAA
P84103 Y33 Sugiyama SRSF3 SFRS3 SRP20 yVGNLGNNGNKtELERAFGyyGPLRSVWVARNPPGFAFVEF
P98175 Y694 Sugiyama RBM10 DXS8237E GPATC9 GPATCH9 KIAA0122 QPISSLRDDERREsAtADAGyAILEKKGALAERQHTsMDLP
Q00341 Y358 Sugiyama HDLBP HBP VGL SETVILRGEPEKLGQALTEVyAKANsFTVSSVAAPSWLHRF
Q02878 Y115 Sugiyama RPL6 TXREB1 PVGGDKNGGTRVVKLRKMPRyyPtEDVPRKLLSHGKKPFSQ
Q04721 T128 Sugiyama NOTCH2 PCFVSRPCLNGGTCHMLSRDtyECtCQVGFTGKECQWTDAC
Q04721 T132 Sugiyama NOTCH2 SRPCLNGGTCHMLSRDtyECtCQVGFTGKECQWTDACLSHP
Q04721 Y129 Sugiyama NOTCH2 CFVSRPCLNGGTCHMLSRDtyECtCQVGFTGKECQWTDACL
Q04760 Y49 Sugiyama GLO1 DFLLQQtMLRVKDPKKSLDFyTRVLGMtLIQKCDFPIMKFS
Q04917 Y49 Sugiyama YWHAH YWHA1 AVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSIEQK
Q05639 Y29 Sugiyama EEF1A2 EEF1AL STN NIVVIGHVDsGKstttGHLIyKCGGIDKRTIEKFEKEAAEM
Q06830 Y116 Sugiyama PRDX1 PAGA PAGB TDPX2 GLGPMNIPLVSDPKRtIAQDyGVLKADEGIsFRGLFIIDDK
Q07912 T430 Sugiyama TNK2 ACK1 NDVITVIEGRAENyWWRGQNtRtLCVGPFPRNVVTsVAGLS
Q07912 T432 Sugiyama TNK2 ACK1 VITVIEGRAENyWWRGQNtRtLCVGPFPRNVVTsVAGLSAQ
Q07912 Y284 SIGNOR|ELM|iPTMNet|EPSD|PSP|Sugiyama TNK2 ACK1 DLVKIGDFGLMRALPQNDDHyVMQEHRKVPFAWCAPESLKT
Q07912 Y423 Sugiyama TNK2 ACK1 DKLHIQMNDVITVIEGRAENyWWRGQNtRtLCVGPFPRNVV
Q07912 Y859 PSP TNK2 ACK1 RAGPCILPIVRDGKKVsstHyyLLPERPSYLERYQRFLREA
Q07912 Y860 PSP TNK2 ACK1 AGPCILPIVRDGKKVsstHyyLLPERPSYLERYQRFLREAQ
Q08043 Y229 Sugiyama ACTN3 KLRKDDPIGNLNTAFEVAEKyLDIPKMLDAEDIVNtPKPDE
Q12874 Y50 Sugiyama SF3A3 SAP61 KSTLRDQINSDHRTRAMQDRyMEVSGNLRDLyDDKDGLRKE
Q12906 Y579 Sugiyama ILF3 DRBF MPHOSPH4 NF90 VEVDGQKFQGAGSNKKVAKAyAALAALEKLFPDtPLALDAN
Q13155 Y35 Sugiyama AIMP2 JTV1 PRO0992 PLRVELPTCMYRLPNVHGRSyGPAPGAGHVQEEsNLsLQAL
Q13177 Y139 Sugiyama PAK2 NPQAVLDVLKFyDsNtVKQKyLsFtPPEKDGFPsGtPALNA
Q13263 S757 Sugiyama TRIM28 KAP1 RNF96 TIF1B TLDLTLIRARLQEKLsPPyssPQEFAQDVGRMFKQFNKLTE
Q13263 Y755 Sugiyama TRIM28 KAP1 RNF96 TIF1B GGTLDLTLIRARLQEKLsPPyssPQEFAQDVGRMFKQFNKL
Q13435 Y639 Sugiyama SF3B2 SAP145 MPVGPNAHKVPPPWLIAMQRyGPPPSyPNLKIPGLNsPIPE
Q13442 S19 Sugiyama PDAP1 HASPP28 __MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEEE
Q13442 T18 Sugiyama PDAP1 HASPP28 ___MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEE
Q13442 Y17 Sugiyama PDAP1 HASPP28 ____MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREE
Q13561 Y313 Sugiyama DCTN2 DCTN50 IAKHKASVEDADTQSKVHQLyEtIQRWsPIASTLPELVQRL
Q13561 Y6 Sugiyama DCTN2 DCTN50 _______________MADPKyADLPGIARNEPDVYETSDLP
Q13765 Y120 Sugiyama NACA HSD48 KNILFVITKPDVYKSPAsDtyIVFGEAKIEDLsQQAQLAAA
Q14157 S859 Sugiyama UBAP2L KIAA0144 NICE4 FPtPttPLtGRDGsLAsNPysGDLtKFGRGDASSPAPATTL
Q14157 Y858 Sugiyama UBAP2L KIAA0144 NICE4 PFPtPttPLtGRDGsLAsNPysGDLtKFGRGDASSPAPATT
Q14204 Y2265 Sugiyama DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325 EGVEGVAHIIDPKAISKDHLyGtLDPNTREWTDGLFTHVLR
Q14240 Y71 Sugiyama EIF4A2 DDX2B EIF4F yGFEKPsAIQQRAIIPCIKGyDVIAQAQsGtGKTATFAISI
Q14247 Y334 Sugiyama CTTN EMS1 KDRMDKNAstFEDVtQVssAyQKTVPVEAVtsKtsNIRANF
Q14247 Y538 Sugiyama CTTN EMS1 IITNIEMIDDGWWRGVCKGRyGLFPANyVELRQ________
Q14247 Y545 Sugiyama CTTN EMS1 IDDGWWRGVCKGRyGLFPANyVELRQ_______________
Q14257 Y127 Sugiyama RCN2 ERC55 VEYDKNSDDTVTWDEyNIQMyDRVIDFDENtALDDAEEEsF
Q14257 Y311 Sugiyama RCN2 ERC55 NPDLFLtsEAtDyGRQLHDDyFyHDEL______________
Q14320 Y53 Sugiyama FAM50A DXS9928E HXC26 XAP5 QRIAEENIMKSNIDKKFsAHyDAVEAELKsstVGLVtLNDM
Q14444 Y99 Sugiyama CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105 QERMNKGERLNQDQLDAVsKyQEVtNNLEFAKELQRsFMAL
Q14568 Y283 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 sDEEEEKKDGDKKKKKTKEKyIDQEELNKTKPIWTRNPDDI
Q14677 Y159 Sugiyama CLINT1 ENTH EPN4 EPNR KIAA0171 AQDDDRLREERKKAKKNKDKyVGVssDsVGGFRysERYDPE
Q14966 Y217 Sugiyama ZNF638 NP220 ZFML ETLGSEAVSSNVIDYGHASKyGYTEDPLEVRIYDPEIPTDE
Q14974 Y529 Sugiyama KPNB1 NTF97 KLLETTDRPDGHQNNLRSSAyEsLMEIVKNSAKDCYPAVQK
Q14CX7 Y19 Sugiyama NAA25 C12orf30 MDM20 NAP1 __MATRGHVQDPNDRRLRPIyDyLDNGNNKMAIQQADKLLK
Q15021 Y1325 Sugiyama NCAPD2 CAPD2 CNAP1 KIAA0159 IGQAGsQRAPsAKKPSTGSRyQPLAstAsDNDFVtPEPRRT
Q15293 Y278 Sugiyama RCN1 RCN LNKDGKLDKDEIRHWILPQDyDHAQAEARHLVyESDKNKDE
Q15369 Y18 Sugiyama ELOC TCEB1 ___MDGEEKtyGGCEGPDAMyVKLISSDGHEFIVKREHALt
Q15417 Y261 Sugiyama CNN3 STISLQMGTNKVAsQKGMsVyGLGRQVYDPKYCAAPTEPVI
Q15459 Y456 Sugiyama SF3A1 SAP114 PRWLEQRDRSIREKQsDDEVyAPGLDIESsLKQLAERRtDI
Q15527 Y123 Sugiyama SURF2 GRRYQRALCKYEECQKQGVEyVPACLVHRRRRREDQMDGDG
Q15654 Y123 Sugiyama TRIP6 OIP1 tLAELNGGRGHASRRPDRQAyEPPPPPAyRtGsLKPNPAsP
Q16719 Y441 Sugiyama KYNU RGVVCDKRNPNGIRVAPVPLyNsFHDVyKFTNLLtsILDsA
Q16719 Y448 Sugiyama KYNU RNPNGIRVAPVPLyNsFHDVyKFTNLLtsILDsAETKN___
Q3SXM5 Y133 Sugiyama HSDL1 SDR12C3 DTYKVETDIIVADFSSGREIyLPIREALKDKDVGILVNNVG
Q4VXU2 Y291 Sugiyama PABPC1L C20orf119 ERQNELKRRFEQMKQDRLRRyQGVNLyVKNLDDSIDDDKLR
Q562R1 Y241 Sugiyama ACTBL2 ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q58FF6 Y32 Sugiyama HSP90AB4P KEIFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDII
Q58FF7 Y56 Sugiyama HSP90AB3P HSP90BC EEIFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDII
Q58FF8 Y198 Sugiyama HSP90AB2P HSP90BB DEEDDsGKDKKKKTKKIKEKyIDQEELNKTKPIWTRNTEDI
Q58FF8 Y260 Sugiyama HSP90AB2P HSP90BB VRYFSVEEYVSRMKEIQKsIyyItGEsKEQVANSAFVEQVW
Q58FF8 Y56 Sugiyama HSP90AB2P HSP90BB KEIFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDII
Q58FG0 Y177 Sugiyama HSP90AA5P HSP90AE GQLEELKDSRRVMKANQKHIyyItGETKDQVANSAFVECLQ
Q5JTH9 Y1251 Sugiyama RRP12 KIAA0690 AEYKAKKAKGDVKKKGRPDPyAyIPLNRSKLNRRKKMKLQG
Q5QNW6 Y43 Sugiyama H2BC18 HIST2H2BF QKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMGIM
Q5VTE0 Y29 Sugiyama EEF1A1P5 EEF1AL3 NIVVIGHVDsGKstttGHLIyKCGGIDKRTIEKFEKEAAEM
Q5VTE0 Y86 Sugiyama EEF1A1P5 EEF1AL3 ERERGITIDISLWKFEtsKyyVtIIDAPGHRDFIKNMITGT
Q5VV41 Y216 Sugiyama ARHGEF16 EPHEXIN4 NBR KKTLGRKRGHKGsFKDDPQLyQEIQERGLNtsQEsDDDILD
Q6PIW4 Y663 Sugiyama FIGNL1 DFENAFRTVRPSVSPKDLELyENWNKTFGCGK_________
Q6S8J3 Y940 Sugiyama POTEE A26C1A POTE2 ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q71U36 Y312 Sugiyama TUBA1A TUBA3 tNACFEPANQMVKCDPRHGKyMACCLLyRGDVVPKDVNAAI
Q7KZF4 Y476 Sugiyama SND1 TDRD11 SKGLATVIRYRQDDDQRssHyDELLAAEARAIKNGKGLHSK
Q86SX6 Y88 Sugiyama GLRX5 C14orf87 GFSNAVVQILRLHGVRDyAAyNVLDDPELRQGIKDYSNWPT
Q8IWW6 Y243 Sugiyama ARHGAP12 sTEQIRAttPPNQGRPDsPVyANLQELKISQSALPPLPGSP
Q8N0Y7 S137 Sugiyama PGAM4 PGAM3 RsyDVPPPPMEPDHPFysNIsKDRRYADLTEDQLPSYESPK
Q8N0Y7 Y119 Sugiyama PGAM4 PGAM3 NKAETAAKHGEAQVKIWRRsyDVPPPPMEPDHPFysNIsKD
Q8N0Y7 Y92 Sugiyama PGAM4 PGAM3 DAIDQMWLPVVRTWRLNERHyGGLtGLNKAETAAKHGEAQV
Q8NBS9 Y251 Sugiyama TXNDC5 TLP46 UNQ364/PRO700 ALGLEHSETVKIGKVDCtQHyELCsGNQVRGyPtLLWFRDG
Q8NI22 Y135 Sugiyama MCFD2 SDNSF DELINIIDGVLRDDDKNNDGyIDyAEFAKSLQ_________
Q8TD19 Y52 Sugiyama NEK9 KIAA1995 NEK8 NERCC PSASQGPRAGGGAAEQEELHyIPIRVLGRGAFGEAtLyRRT
Q8WUA2 Y363 Sugiyama PPIL4 QDKPPNLVLKDKVKPKQDtKyDLILDEQAEDsKSSHSHTSK
Q8WX92 Y541 Sugiyama NELFB COBRA1 KIAA1182 EALQKALEPTGQSGEAVKELysQLGEKLEQLDHRKPsPAQA
Q8WX93 Y1348 Sugiyama PALLD KIAA0992 CGI-151 QWHQQsQstKPKKVRPSASRyAALsDQGLDIKAAFQPEANP
Q8WYP5 Y1790 Sugiyama AHCTF1 ELYS TMBS62 MSTP108 QSVRKKTRKAKEISEASENIySDVRGLsQNQQIPQNsVtPR
Q92615 Y596 Sugiyama LARP4B KIAA0217 LARP5 LPVVVSREPsVPAsCAVsAtyERsPsPAHLPDDPKVAEKQR
Q93052 Y301 Sugiyama LPP LQPEPGYGYAPNQGRyyEGyyAAGPGyGGRNDsDPtyGQQG
Q93079 Y43 Sugiyama H2BC9 H2BFJ HIST1H2BH QKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMGIM
Q96AE4 Y626 Sugiyama FUBP1 GGQPDYSAAWAEYYRQQAAyyAQtsPQGMPQHPPAPQGQ__
Q96QK1 Y791 Sugiyama VPS35 MEM3 TCCCTA00141 HNtLEHLRLRREsPEsEGPIyEGLIL_______________
Q96RP9 Y720 Sugiyama GFM1 EFG EFG1 GFM STELRSCTEGKGEYTMEySRyQPCLPStQEDVINKYLEATG
Q96T37 Y608 Sugiyama RBM15 OTT OTT1 PPPPPVRERSTRTAATsVPAyEPLDSLDRRRDGWsLDRDRG
Q96T58 Y116 Sugiyama SPEN KIAA0929 MINT SHARP sIAsRSREVSGFRGGGGGPAyGPPPSLHAREGRYERRLDGA
Q99459 Y788 Sugiyama CDC5L KIAA0432 PCDC5RP ECLKEDVQRQQEREKELQHRyADLLLEKETLKSKF______
Q99460 Y494 Sugiyama PSMD1 RHGGSLGLGLAAMGTARQDVyDLLKTNLYQDDAVTGEAAGL
Q99613 T880 Sugiyama EIF3C EIF3S8 AEKLGsLVENNERVFDHKQGtyGGyFRDQKDGYRKNEGYMR
Q99613 Y881 Sugiyama EIF3C EIF3S8 EKLGsLVENNERVFDHKQGtyGGyFRDQKDGYRKNEGYMRR
Q99733 Y99 Sugiyama NAP1L4 NAP2 HIEAKFyEEVHDLERKyAALyQPLFDKRREFItGDVEPtDA
Q99798 Y71 Sugiyama ACO2 NINIVRKRLNRPLTLSEKIVyGHLDDPAsQEIERGKSYLRL
Q99877 Y43 Sugiyama H2BC15 H2BFD HIST1H2BN QKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMGIM
Q99879 Y43 Sugiyama H2BC14 H2BFE HIST1H2BM QKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMGIM
Q99880 Y43 Sugiyama H2BC13 H2BFC HIST1H2BL QKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMGIM
Q9BQE3 Y312 Sugiyama TUBA1C TUBA6 TNACFEPANQMVKCDPRHGKyMACCLLyRGDVVPKDVNAAI
Q9BU89 Y290 Sugiyama DOHH HLRC1 RESCEVALDMyEHETGRAFQyADGLEQLRGAPS________
Q9BWF3 Y194 Sugiyama RBM4 RBM4A ECPIDRSGRVADLTEQYNEQyGAVRTPYTMSYGDSLYYNNA
Q9BYX7 Y240 Sugiyama POTEKP ACTBL3 FKSG30 ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9BZZ5 Y28 Sugiyama API5 MIG8 YRNyGILADATEQVGQHKDAyQVILDGVKGGTKEKRLAAQF
Q9C0C2 Y918 Sugiyama TNKS1BP1 KIAA1741 TAB182 AsQDANEQGQDLGKRDHHGRyssQDADEQDWEFQKRDVsLG
Q9H4M9 Y339 Sugiyama EHD1 PAST PAST1 CDABP0131 PNVFGKESKKKELVNNLGEIyQKIEREHQIsPGDFPsLRKM
Q9H6T3 Y90 Sugiyama RPAP3 KESSKKTREENTKNRIKsyDyEAWAKLDVDRILDELDKDDs
Q9H814 Y57 Sugiyama PHAX RNUXA GDsAMRAFQNTAtACAPVSHyRAVESVDSSEESFSDSDDDS
Q9HB07 Y189 Sugiyama MYG1 C12orf10 VEEVDAVDNGISQWAEGEPRyALttTLsARVARLNPTWNHP
Q9HC35 T554 Sugiyama EML4 C2orf2 EMAPL4 ILWDHDLNPEREIEVPDQyGtIRAVAEGKADQFLVGTSRNF
Q9NP61 Y408 Sugiyama ARFGAP3 ARFGAP1 ETVLKTTGYSDRPTARRKPDyEPVENTDEAQKKFGNVKAIs
Q9NRX4 Y113 Sugiyama PHPT1 PHP14 CGI-202 HSPC141 ysMAyGPAQHAISTEKIKAKyPDyEVtWANDGy________
Q9NRX4 Y57 Sugiyama PHPT1 PHP14 CGI-202 HSPC141 AAESKEIVRGYKWAEyHADIyDKVSGDMQKQGCDCECLGGG
Q9NWS0 Y194 Sugiyama PIH1D1 NOP17 IsQQNIRSEQRPRIQELGDLytPAPGRAESGPEKPHLNLWL
Q9NXZ1 Y340 Sugiyama SAGE1 SAGE QPVIIYLTATGIPGMNTRDQyATITHNVCEERVVNNQPLPS
Q9NXZ1 Y528 Sugiyama SAGE1 SAGE APQLGHMAAGGIPSMSTKDLyATVTQNVHEERMENNQPQPS
Q9NZC7 Y287 EPSD|PSP WWOX FOR SDR41C1 WOX1 DINDSLGKLDFSRLSPTKNDyWAMLAYNRSKLCNILFSNEL
Q9P0P0 T153 Sugiyama RNF181 HSPC238 DKARKQQQQHRLENLHGAMyt____________________
Q9UBR2 Y76 Sugiyama CTSZ YLSPADLPKSWDWRNVDGVNyAsItRNQHIPQYCGSCWAHA
Q9UBS4 Y74 Sugiyama DNAJB11 EDJ ERJ3 HDJ9 PSEC0121 UNQ537/PRO1080 PDRNPDDPQAQEKFQDLGAAyEVLsDSEKRKQyDTyGEEGL
Q9UHR5 Y165 Sugiyama SAP30BP HCNGP HTRG HTRP EGMDMNyIIQRKKEFRNPsIyEKLIQFCAIDELGTNYPKDM
Q9UI15 Y192 Sugiyama TAGLN3 NP25 NVIGLQMGSNKGAsQAGMtGyGMPRQIM_____________
Q9UK59 Y533 Sugiyama DBR1 LsDEHEPEQRKKIKRRNQAIyAAVDDDDDDAA_________
Q9UKS6 Y374 Sugiyama PACSIN3 sDEEsPRKAATGVRVRALyDyAGQEADELsFRAGEELLKMS
Q9UKY7 Y244 Sugiyama CDV3 H41 NRGRDEVSKNQALKLQLDNQyAVLENQKSSHSQYN______
Q9UMX5 Y65 Sugiyama NENF CIR2 SPUF RLFtEEELARYGGEEEDQPIyLAVKGVVFDVtSGKEFYGRG
Q9UMY4 Y72 Sugiyama SNX12 VRMRTNLPIFKLKESCVRRRysDFEWLKNELERDSKIVVPP
Q9UN86 Y20 Sugiyama G3BP2 KIAA0660 _MVMEKPsPLLVGREFVRQyytLLNKAPEYLHRFYGRNSSY
Q9UQ35 S846 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 KSKtPsRQsHSsssPHPKVKsGtPPRQGsItsPQANEQsVt
Q9Y262 Y45 Sugiyama EIF3L EIF3EIP EIF3S6IP HSPC021 HSPC025 MSTP005 MHTGDPKQDLAyERQyEQQtyQVIPEVIKNFIQYFHKTVSD
Q9Y281 Y82 Sugiyama CFL2 DTVEDPYtsFVKLLPLNDCRyALyDAtyEtKESKKEDLVFI
Q9Y281 Y85 Sugiyama CFL2 EDPYtsFVKLLPLNDCRyALyDAtyEtKESKKEDLVFIFWA
Q9Y2T7 Y107 Sugiyama YBX2 CSDA3 MSY2 KPVLAIQVLGTVKWFNVRNGyGFINRNDtKEDVFVHQtAIK
Q9Y3D8 Y31 Sugiyama AK6 CINAP AD-004 CGI-137 TPGVGKTTLGKELASKSGLKyINVGDLAREEQLYDGYDEEY
Q9Y3F4 Y300 Sugiyama STRAP MAWD UNRIP yAsGSEDGTLRLWQTVVGKtyGLWKCVLPEEDsGELAKPKI
Q9Y3P9 Y472 Sugiyama RABGAP1 HSPC094 FFLKLKQIKQRERKNNTDTLyEVVCLESESERERRKTTAsP
Q9Y4C1 Y1114 SIGNOR|EPSD|PSP KDM3A JHDM2A JMJD1 JMJD1A KIAA0742 TSGA PDLGPKMyNAYGLITPEDRKyGTTNLHLDVSDAANVMVYVG
Q9Y4H2 S805 Sugiyama IRS2 sAALHPGGEPLRGVPGCCyssLPRSYKAPytCGGDsDQyVL
Q9Y4L1 Y759 Sugiyama HYOU1 GRP170 HSPH4 ORP150 AANsLEAFIFEtQDKLyQPEyQEVsTEEQREEISGKLSAAS
Q9Y5P6 Y144 Sugiyama GMPPB HRHHGQEGSILVTKVEEPSKyGVVVCEADTGRIHRFVEKPQ
Q9Y5S9 S56 Sugiyama RBM8A RBM8 HSPC114 MDS014 KGRGFGsEEGsRARMREDyDsVEQDGDEPGPQRSVEGWILF
Q9Y5S9 Y54 Sugiyama RBM8A RBM8 HSPC114 MDS014 KRKGRGFGsEEGsRARMREDyDsVEQDGDEPGPQRSVEGWI
Q9Y639 Y220 Sugiyama NPTN SDFR1 SDR1 NMEYRINKPRAEDsGEyHCVyHFVsAPKANATIEVKAAPDI
Q9Y6N7 Y1114 Sugiyama ROBO1 DUTT1 sGEKHWKPLGQQKQEVAPVQyNIVEQNKLNKDYRANDTVPP
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 9.375005e-10 9.028 1 0
Downregulation of ERBB2 signaling R-HSA-8863795 6.932872e-09 8.159 0 0
Signaling by ERBB2 R-HSA-1227986 6.420912e-08 7.192 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.717782e-06 5.765 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.231805e-06 5.651 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.021451e-06 5.991 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.465530e-06 5.608 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.894149e-06 5.538 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 5.107680e-06 5.292 0 0
Signal Transduction R-HSA-162582 5.635400e-06 5.249 1 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.291516e-05 4.889 0 0
Signaling by PTK6 R-HSA-8848021 1.291516e-05 4.889 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.411249e-05 4.850 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 1.829084e-05 4.738 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.923863e-05 4.534 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.713291e-05 4.327 0 0
Prolonged ERK activation events R-HSA-169893 6.935448e-05 4.159 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.360857e-05 4.078 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 8.199238e-05 4.086 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 9.988138e-05 4.001 0 0
Synaptic adhesion-like molecules R-HSA-8849932 1.183386e-04 3.927 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.235525e-04 3.908 0 0
Signaling by VEGF R-HSA-194138 1.430551e-04 3.844 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 2.395278e-04 3.621 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 2.491549e-04 3.604 0 0
Signaling by ERBB4 R-HSA-1236394 2.707560e-04 3.567 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 3.075795e-04 3.512 0 0
Leishmania phagocytosis R-HSA-9664417 3.075795e-04 3.512 0 0
Parasite infection R-HSA-9664407 3.075795e-04 3.512 0 0
Long-term potentiation R-HSA-9620244 3.656562e-04 3.437 0 0
RAF/MAP kinase cascade R-HSA-5673001 5.172112e-04 3.286 0 0
Post NMDA receptor activation events R-HSA-438064 6.174626e-04 3.209 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 6.211480e-04 3.207 0 0
MAPK family signaling cascades R-HSA-5683057 6.114359e-04 3.214 0 0
Signalling to ERKs R-HSA-187687 1.125726e-03 2.949 0 0
Signaling by FGFR1 amplification mutants R-HSA-1839120 1.353256e-03 2.869 0 0
TRKA activation by NGF R-HSA-187042 1.353256e-03 2.869 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 1.342492e-03 2.872 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.353256e-03 2.869 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.407264e-03 2.852 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.417793e-03 2.848 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 1.542109e-03 2.812 0 0
Parasitic Infection Pathways R-HSA-9824443 1.541206e-03 2.812 0 0
Leishmania infection R-HSA-9658195 1.541206e-03 2.812 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 1.694570e-03 2.771 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 1.622345e-03 2.790 0 0
Generation of second messenger molecules R-HSA-202433 1.694570e-03 2.771 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.759391e-03 2.755 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.759391e-03 2.755 0 0
Regulation of gap junction activity R-HSA-191650 1.935164e-03 2.713 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.935164e-03 2.713 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.969490e-03 2.706 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.994879e-03 2.700 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.141495e-03 2.669 0 0
Regulation of signaling by CBL R-HSA-912631 2.249092e-03 2.648 0 0
L1CAM interactions R-HSA-373760 2.838905e-03 2.547 0 0
Co-stimulation by CD28 R-HSA-389356 3.173318e-03 2.498 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 3.462792e-03 2.461 0 0
Gap junction trafficking and regulation R-HSA-157858 3.378483e-03 2.471 0 0
PI3K Cascade R-HSA-109704 3.592496e-03 2.445 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 3.392763e-03 2.469 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 3.817642e-03 2.418 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 4.591867e-03 2.338 0 0
Activation of TRKA receptors R-HSA-187015 5.228077e-03 2.282 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 5.228077e-03 2.282 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 4.801477e-03 2.319 0 0
Signaling by Insulin receptor R-HSA-74752 4.922250e-03 2.308 0 0
Nervous system development R-HSA-9675108 5.310089e-03 2.275 0 0
IRS-mediated signalling R-HSA-112399 5.353107e-03 2.271 0 0
Intracellular signaling by second messengers R-HSA-9006925 5.647288e-03 2.248 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 6.580266e-03 2.182 0 0
FOXO-mediated transcription R-HSA-9614085 6.713887e-03 2.173 0 0
Activation of BH3-only proteins R-HSA-114452 6.919892e-03 2.160 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 7.258305e-03 2.139 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 7.258305e-03 2.139 0 0
ARMS-mediated activation R-HSA-170984 7.424773e-03 2.129 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 7.424773e-03 2.129 0 0
AURKA Activation by TPX2 R-HSA-8854518 8.359304e-03 2.078 0 0
FGFR1 mutant receptor activation R-HSA-1839124 8.597633e-03 2.066 0 0
Integrin signaling R-HSA-354192 8.597633e-03 2.066 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.597633e-03 2.066 0 0
IGF1R signaling cascade R-HSA-2428924 7.613967e-03 2.118 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 7.980920e-03 2.098 0 0
Axon guidance R-HSA-422475 7.774018e-03 2.109 0 0
Insulin receptor signalling cascade R-HSA-74751 7.613967e-03 2.118 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 1.136293e-02 1.945 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 1.136293e-02 1.945 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.133942e-02 1.945 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 1.049402e-02 1.979 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 9.837262e-03 2.007 0 0
Gap junction assembly R-HSA-190861 9.837262e-03 2.007 0 0
GPVI-mediated activation cascade R-HSA-114604 1.117564e-02 1.952 0 0
TCR signaling R-HSA-202403 1.019046e-02 1.992 0 0
RUNX2 regulates bone development R-HSA-8941326 1.117564e-02 1.952 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.158082e-02 1.936 0 0
Signaling by FGFR in disease R-HSA-1226099 1.181402e-02 1.928 0 0
Hemostasis R-HSA-109582 1.227417e-02 1.911 0 0
Centrosome maturation R-HSA-380287 1.230121e-02 1.910 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.283952e-02 1.891 0 0
Neutrophil degranulation R-HSA-6798695 1.371082e-02 1.863 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.387123e-02 1.858 0 0
Frs2-mediated activation R-HSA-170968 1.439495e-02 1.842 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.496177e-02 1.825 0 0
DCC mediated attractive signaling R-HSA-418885 1.773513e-02 1.751 0 0
Gap junction trafficking R-HSA-190828 1.845079e-02 1.734 0 0
Signaling by SCF-KIT R-HSA-1433557 1.753987e-02 1.756 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.788832e-02 1.747 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.845079e-02 1.734 0 0
Netrin-1 signaling R-HSA-373752 1.845079e-02 1.734 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.726962e-02 1.763 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.579543e-02 1.801 0 0
Protein methylation R-HSA-8876725 1.773513e-02 1.751 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.665477e-02 1.778 0 0
Neuronal System R-HSA-112316 1.595852e-02 1.797 0 0
MHC class II antigen presentation R-HSA-2132295 1.605731e-02 1.794 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.938758e-02 1.712 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.050038e-02 1.688 0 0
Signaling by Interleukins R-HSA-449147 2.105024e-02 1.677 0 0
Recycling pathway of L1 R-HSA-437239 2.133885e-02 1.671 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.136933e-02 1.670 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.156165e-02 1.666 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.188982e-02 1.660 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 2.329239e-02 1.633 0 0
Signaling by Hippo R-HSA-2028269 2.329239e-02 1.633 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.135819e-02 1.504 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 3.135819e-02 1.504 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.135819e-02 1.504 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 3.135819e-02 1.504 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.135819e-02 1.504 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.528387e-02 1.597 0 0
FGFR1 ligand binding and activation R-HSA-190242 2.528387e-02 1.597 0 0
GAB1 signalosome R-HSA-180292 2.528387e-02 1.597 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.946550e-02 1.531 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.946550e-02 1.531 0 0
Transport of connexins along the secretory pathway R-HSA-190827 3.135819e-02 1.504 0 0
Oligomerization of connexins into connexons R-HSA-190704 3.135819e-02 1.504 0 0
Signal transduction by L1 R-HSA-445144 2.946550e-02 1.531 0 0
COPI-mediated anterograde transport R-HSA-6807878 2.801535e-02 1.553 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.528387e-02 1.597 0 0
Immune System R-HSA-168256 2.665967e-02 1.574 0 0
Innate Immune System R-HSA-168249 2.952770e-02 1.530 0 0
Signaling by EGFR R-HSA-177929 3.140179e-02 1.503 0 0
Signaling by FGFR1 R-HSA-5654736 3.140179e-02 1.503 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.140179e-02 1.503 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 3.165246e-02 1.500 0 0
Signaling by NTRKs R-HSA-166520 3.297790e-02 1.482 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.506694e-02 1.455 0 0
Adaptive Immune System R-HSA-1280218 3.543012e-02 1.451 0 0
Kinesins R-HSA-983189 3.654287e-02 1.437 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 4.159212e-02 1.381 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 4.159212e-02 1.381 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 4.159212e-02 1.381 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 4.159212e-02 1.381 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 4.159212e-02 1.381 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 4.159212e-02 1.381 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 4.159212e-02 1.381 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 4.159212e-02 1.381 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 4.159212e-02 1.381 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 4.159212e-02 1.381 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 4.159212e-02 1.381 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.857921e-02 1.414 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 4.100505e-02 1.387 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 4.100505e-02 1.387 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 4.100505e-02 1.387 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 4.861283e-02 1.313 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 4.861283e-02 1.313 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.957864e-02 1.305 0 0
FCERI mediated MAPK activation R-HSA-2871796 4.412396e-02 1.355 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 3.845459e-02 1.415 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 4.861283e-02 1.313 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.894485e-02 1.410 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.602328e-02 1.337 0 0
Signaling by ALK in cancer R-HSA-9700206 3.894485e-02 1.410 0 0
Apoptosis R-HSA-109581 4.405208e-02 1.356 0 0
Cytokine Signaling in Immune system R-HSA-1280215 4.376700e-02 1.359 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 5.125413e-02 1.290 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 5.125413e-02 1.290 0 0
PLC-gamma1 signalling R-HSA-167021 5.171856e-02 1.286 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 5.171856e-02 1.286 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 5.171856e-02 1.286 0 0
Signalling to STAT3 R-HSA-198745 5.171856e-02 1.286 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 5.394583e-02 1.268 0 0
Signaling by Erythropoietin R-HSA-9006335 5.394583e-02 1.268 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 5.437366e-02 1.265 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 5.600615e-02 1.252 0 0
DAP12 signaling R-HSA-2424491 5.668656e-02 1.247 0 0
Interleukin-37 signaling R-HSA-9008059 5.668656e-02 1.247 0 0
ESR-mediated signaling R-HSA-8939211 5.759682e-02 1.240 0 0
EGFR downregulation R-HSA-182971 5.947502e-02 1.226 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 5.947502e-02 1.226 0 0
Downstream signal transduction R-HSA-186763 5.947502e-02 1.226 0 0
TNFR1-mediated ceramide production R-HSA-5626978 6.173862e-02 1.209 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 6.173862e-02 1.209 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 6.173862e-02 1.209 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 6.173862e-02 1.209 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 6.173862e-02 1.209 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 6.173862e-02 1.209 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 6.230990e-02 1.205 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 6.518991e-02 1.186 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 6.714450e-02 1.173 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 6.815196e-02 1.167 0 0
FGFR1c and Klotho ligand binding and activation R-HSA-190374 7.165341e-02 1.145 0 0
NGF-independant TRKA activation R-HSA-187024 8.146404e-02 1.089 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 8.146404e-02 1.089 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 8.146404e-02 1.089 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 8.146404e-02 1.089 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 8.146404e-02 1.089 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 9.117159e-02 1.040 0 0
MET promotes cell motility R-HSA-8875878 8.334906e-02 1.079 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 8.146404e-02 1.089 0 0
Reelin signalling pathway R-HSA-8866376 7.165341e-02 1.145 0 0
Activation of AKT2 R-HSA-165158 7.165341e-02 1.145 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 7.408835e-02 1.130 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 8.146404e-02 1.089 0 0
PDE3B signalling R-HSA-165160 8.146404e-02 1.089 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 8.146404e-02 1.089 0 0
PKB-mediated events R-HSA-109703 8.146404e-02 1.089 0 0
Reuptake of GABA R-HSA-888593 1.007771e-01 0.997 0 0
EPH-Ephrin signaling R-HSA-2682334 9.563416e-02 1.019 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 9.117159e-02 1.040 0 0
DAP12 interactions R-HSA-2172127 1.061941e-01 0.974 0 0
Aggrephagy R-HSA-9646399 8.970868e-02 1.047 0 0
NrCAM interactions R-HSA-447038 7.165341e-02 1.145 0 0
Membrane Trafficking R-HSA-199991 1.015147e-01 0.993 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 8.146404e-02 1.089 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 7.538870e-02 1.123 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.620659e-02 1.017 0 0
Transmission across Chemical Synapses R-HSA-112315 7.466505e-02 1.127 0 0
Ion channel transport R-HSA-983712 7.217907e-02 1.142 0 0
Pentose phosphate pathway R-HSA-71336 8.651104e-02 1.063 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 8.540189e-02 1.069 0 0
Programmed Cell Death R-HSA-5357801 9.311721e-02 1.031 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.001433e-01 0.999 0 0
FLT3 Signaling R-HSA-9607240 9.294089e-02 1.032 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.061941e-01 0.974 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.063916e-01 0.973 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 1.102818e-01 0.957 0 0
Formation of annular gap junctions R-HSA-196025 1.102818e-01 0.957 0 0
FGFR1b ligand binding and activation R-HSA-190370 1.102818e-01 0.957 0 0
MET receptor recycling R-HSA-8875656 1.102818e-01 0.957 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 1.102818e-01 0.957 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 1.102818e-01 0.957 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.102818e-01 0.957 0 0
Signaling by FGFR R-HSA-190236 1.108222e-01 0.955 0 0
Death Receptor Signaling R-HSA-73887 1.119683e-01 0.951 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.130010e-01 0.947 0 0
Apoptotic execution phase R-HSA-75153 1.130010e-01 0.947 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 1.164461e-01 0.934 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.175989e-01 0.930 0 0
Gap junction degradation R-HSA-190873 1.196865e-01 0.922 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.196865e-01 0.922 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 1.196865e-01 0.922 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.196865e-01 0.922 0 0
Intraflagellar transport R-HSA-5620924 1.199176e-01 0.921 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.199176e-01 0.921 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.289924e-01 0.889 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.289924e-01 0.889 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 1.289924e-01 0.889 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.563273e-01 0.806 0 0
Retrograde neurotrophin signalling R-HSA-177504 1.740751e-01 0.759 0 0
SHC1 events in EGFR signaling R-HSA-180336 1.828093e-01 0.738 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.914516e-01 0.718 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.000031e-01 0.699 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 2.333192e-01 0.632 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.494563e-01 0.603 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.494563e-01 0.603 0 0
mRNA 3'-end processing R-HSA-72187 1.340499e-01 0.873 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.414304e-01 0.617 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.414304e-01 0.617 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.084647e-01 0.681 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.084647e-01 0.681 0 0
Formation of definitive endoderm R-HSA-9823730 2.333192e-01 0.632 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 2.251218e-01 0.648 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 2.333192e-01 0.632 0 0
PI3K/AKT activation R-HSA-198203 1.289924e-01 0.889 0 0
Signaling by Leptin R-HSA-2586552 1.289924e-01 0.889 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 2.494563e-01 0.603 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 1.563273e-01 0.806 0 0
GRB2 events in EGFR signaling R-HSA-179812 1.563273e-01 0.806 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.652481e-01 0.782 0 0
FGFR1c ligand binding and activation R-HSA-190373 1.652481e-01 0.782 0 0
G-protein activation R-HSA-202040 2.414304e-01 0.617 0 0
Processing of SMDT1 R-HSA-8949664 1.652481e-01 0.782 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.494563e-01 0.603 0 0
Germ layer formation at gastrulation R-HSA-9754189 2.251218e-01 0.648 0 0
TNF signaling R-HSA-75893 1.485336e-01 0.828 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.289924e-01 0.889 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 1.289924e-01 0.889 0 0
Ionotropic activity of kainate receptors R-HSA-451306 1.382005e-01 0.859 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.563273e-01 0.806 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.670520e-01 0.777 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.449454e-01 0.611 0 0
Signaling by FGFR4 in disease R-HSA-5655291 1.740751e-01 0.759 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 1.586614e-01 0.800 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.400901e-01 0.620 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 1.899177e-01 0.721 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.479111e-01 0.606 0 0
Regulation of KIT signaling R-HSA-1433559 1.740751e-01 0.759 0 0
Erythropoietin activates RAS R-HSA-9027284 1.828093e-01 0.738 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 2.251218e-01 0.648 0 0
Mitotic Prometaphase R-HSA-68877 1.898187e-01 0.722 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 2.000031e-01 0.699 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.251218e-01 0.648 0 0
Signaling by NODAL R-HSA-1181150 2.333192e-01 0.632 0 0
Cilium Assembly R-HSA-5617833 1.834595e-01 0.736 0 0
Signaling by Activin R-HSA-1502540 1.828093e-01 0.738 0 0
Signalling to RAS R-HSA-167044 2.414304e-01 0.617 0 0
Mitochondrial calcium ion transport R-HSA-8949215 2.494563e-01 0.603 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.708030e-01 0.768 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.494563e-01 0.603 0 0
NCAM signaling for neurite out-growth R-HSA-375165 1.708030e-01 0.768 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.494563e-01 0.603 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.089749e-01 0.680 0 0
Signaling by MET R-HSA-6806834 2.400901e-01 0.620 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 2.115028e-01 0.675 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.563273e-01 0.806 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.382005e-01 0.859 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 1.382005e-01 0.859 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.828093e-01 0.738 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.828093e-01 0.738 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 1.914516e-01 0.718 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.400901e-01 0.620 0 0
Vesicle-mediated transport R-HSA-5653656 1.728908e-01 0.762 0 0
G2/M Transition R-HSA-69275 1.750947e-01 0.757 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.792605e-01 0.747 0 0
PECAM1 interactions R-HSA-210990 1.382005e-01 0.859 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 1.382005e-01 0.859 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.828093e-01 0.738 0 0
NRAGE signals death through JNK R-HSA-193648 1.485336e-01 0.828 0 0
Developmental Cell Lineages R-HSA-9734767 1.841186e-01 0.735 0 0
Stimuli-sensing channels R-HSA-2672351 1.363911e-01 0.865 0 0
Disease R-HSA-1643685 1.987033e-01 0.702 0 0
Ion transport by P-type ATPases R-HSA-936837 1.783467e-01 0.749 0 0
Developmental Biology R-HSA-1266738 1.419579e-01 0.848 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 1.914516e-01 0.718 0 0
Killing mechanisms R-HSA-9664420 1.914516e-01 0.718 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.225821e-01 0.653 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.652481e-01 0.782 0 0
Signal regulatory protein family interactions R-HSA-391160 1.740751e-01 0.759 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.494563e-01 0.603 0 0
Nephrin family interactions R-HSA-373753 2.333192e-01 0.632 0 0
Cellular responses to stimuli R-HSA-8953897 1.766237e-01 0.753 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 2.051135e-01 0.688 0 0
G alpha (12/13) signalling events R-HSA-416482 2.322817e-01 0.634 0 0
Interleukin-10 signaling R-HSA-6783783 2.322817e-01 0.634 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.236457e-01 0.650 0 0
Signaling by PDGF R-HSA-186797 1.708030e-01 0.768 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.128438e-01 0.672 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 2.494563e-01 0.603 0 0
Dissolution of Fibrin Clot R-HSA-75205 1.382005e-01 0.859 0 0
Peptide ligand-binding receptors R-HSA-375276 1.750947e-01 0.757 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 2.093027e-01 0.679 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 2.206021e-01 0.656 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.821378e-01 0.740 0 0
PKR-mediated signaling R-HSA-9833482 2.400901e-01 0.620 0 0
Interleukin-12 signaling R-HSA-9020591 2.244902e-01 0.649 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 2.573977e-01 0.589 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 2.573977e-01 0.589 0 0
Signaling by KIT in disease R-HSA-9669938 2.573977e-01 0.589 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 2.573977e-01 0.589 0 0
Potential therapeutics for SARS R-HSA-9679191 2.647961e-01 0.577 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.647961e-01 0.577 0 0
Interleukin-20 family signaling R-HSA-8854691 2.652557e-01 0.576 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 2.652557e-01 0.576 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.652557e-01 0.576 0 0
SARS-CoV Infections R-HSA-9679506 2.699344e-01 0.569 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 2.705057e-01 0.568 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.714116e-01 0.566 0 0
Interleukin-12 family signaling R-HSA-447115 2.714116e-01 0.566 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.730309e-01 0.564 0 0
TNFs bind their physiological receptors R-HSA-5669034 2.730309e-01 0.564 0 0
Neurodegenerative Diseases R-HSA-8863678 2.730309e-01 0.564 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.730309e-01 0.564 0 0
Infectious disease R-HSA-5663205 2.751672e-01 0.560 0 0
Selective autophagy R-HSA-9663891 2.753290e-01 0.560 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 2.807243e-01 0.552 0 0
TGFBR3 expression R-HSA-9839394 2.807243e-01 0.552 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 2.807243e-01 0.552 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 2.807243e-01 0.552 0 0
Cell-Cell communication R-HSA-1500931 2.865794e-01 0.543 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.870737e-01 0.542 0 0
MET activates PTK2 signaling R-HSA-8874081 2.883368e-01 0.540 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.883368e-01 0.540 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 2.883368e-01 0.540 0 0
TRP channels R-HSA-3295583 2.883368e-01 0.540 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 2.883368e-01 0.540 0 0
Cell surface interactions at the vascular wall R-HSA-202733 2.918485e-01 0.535 0 0
Organelle biogenesis and maintenance R-HSA-1852241 2.947640e-01 0.531 0 0
Protein folding R-HSA-391251 2.948932e-01 0.530 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 2.958692e-01 0.529 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.958692e-01 0.529 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.958692e-01 0.529 0 0
Cristae formation R-HSA-8949613 2.958692e-01 0.529 0 0
Signaling by FGFR3 in disease R-HSA-5655332 2.958692e-01 0.529 0 0
Signaling by BMP R-HSA-201451 2.958692e-01 0.529 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 2.958692e-01 0.529 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.958692e-01 0.529 0 0
FCGR activation R-HSA-2029481 2.987987e-01 0.525 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 2.987987e-01 0.525 0 0
Mitochondrial protein degradation R-HSA-9837999 3.027008e-01 0.519 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 3.033223e-01 0.518 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 3.033223e-01 0.518 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 3.033223e-01 0.518 0 0
Insulin receptor recycling R-HSA-77387 3.033223e-01 0.518 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 3.106970e-01 0.508 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 3.106970e-01 0.508 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.106970e-01 0.508 0 0
Regulation of gene expression in beta cells R-HSA-210745 3.106970e-01 0.508 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 3.179941e-01 0.498 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 3.179941e-01 0.498 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 3.252144e-01 0.488 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 3.260240e-01 0.487 0 0
Hedgehog 'off' state R-HSA-5610787 3.298931e-01 0.482 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 3.323587e-01 0.478 0 0
G0 and Early G1 R-HSA-1538133 3.323587e-01 0.478 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 3.339046e-01 0.476 0 0
Leishmania parasite growth and survival R-HSA-9664433 3.339046e-01 0.476 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.376129e-01 0.472 0 0
PI Metabolism R-HSA-1483255 3.376129e-01 0.472 0 0
Nuclear RNA decay R-HSA-9930044 3.394277e-01 0.469 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.394277e-01 0.469 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.394277e-01 0.469 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.394277e-01 0.469 0 0
Cardiogenesis R-HSA-9733709 3.394277e-01 0.469 0 0
G-protein beta:gamma signalling R-HSA-397795 3.394277e-01 0.469 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.396852e-01 0.469 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.453062e-01 0.462 0 0
Striated Muscle Contraction R-HSA-390522 3.464224e-01 0.460 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 3.464224e-01 0.460 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 3.464224e-01 0.460 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 3.533434e-01 0.452 0 0
G alpha (q) signalling events R-HSA-416476 3.563417e-01 0.448 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 3.601916e-01 0.443 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.644088e-01 0.438 0 0
RET signaling R-HSA-8853659 3.669676e-01 0.435 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.669676e-01 0.435 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.682048e-01 0.434 0 0
Voltage gated Potassium channels R-HSA-1296072 3.736724e-01 0.428 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 3.736724e-01 0.428 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 3.736724e-01 0.428 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.736724e-01 0.428 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.736724e-01 0.428 0 0
Metabolism of folate and pterines R-HSA-196757 3.736724e-01 0.428 0 0
Inositol phosphate metabolism R-HSA-1483249 3.795393e-01 0.421 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 3.803065e-01 0.420 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 3.868707e-01 0.412 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.868707e-01 0.412 0 0
Signaling by ALK R-HSA-201556 3.868707e-01 0.412 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.868707e-01 0.412 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 3.922994e-01 0.406 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 3.933658e-01 0.405 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 3.933658e-01 0.405 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 3.933658e-01 0.405 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 3.933658e-01 0.405 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 3.982382e-01 0.400 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 3.997925e-01 0.398 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.997925e-01 0.398 0 0
HCMV Early Events R-HSA-9609690 3.999824e-01 0.398 0 0
HIV Transcription Initiation R-HSA-167161 4.061515e-01 0.391 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 4.061515e-01 0.391 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 4.061515e-01 0.391 0 0
MAP2K and MAPK activation R-HSA-5674135 4.061515e-01 0.391 0 0
Signaling by RAF1 mutants R-HSA-9656223 4.061515e-01 0.391 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 4.061515e-01 0.391 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.124436e-01 0.385 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 4.124436e-01 0.385 0 0
MTOR signalling R-HSA-165159 4.124436e-01 0.385 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 4.186693e-01 0.378 0 0
Signaling by FGFR4 R-HSA-5654743 4.186693e-01 0.378 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 4.186693e-01 0.378 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 4.203286e-01 0.376 0 0
Cellular response to heat stress R-HSA-3371556 4.203286e-01 0.376 0 0
RMTs methylate histone arginines R-HSA-3214858 4.248295e-01 0.372 0 0
mRNA Splicing R-HSA-72172 4.254071e-01 0.371 0 0
M Phase R-HSA-68886 4.262794e-01 0.370 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 4.309248e-01 0.366 0 0
Signaling by FGFR3 R-HSA-5654741 4.309248e-01 0.366 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.309248e-01 0.366 0 0
Cell Cycle, Mitotic R-HSA-69278 4.318184e-01 0.365 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.369558e-01 0.360 0 0
Signaling downstream of RAS mutants R-HSA-9649948 4.369558e-01 0.360 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 4.369558e-01 0.360 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 4.369558e-01 0.360 0 0
Signaling by RAS mutants R-HSA-6802949 4.369558e-01 0.360 0 0
Signaling by TGFBR3 R-HSA-9839373 4.369558e-01 0.360 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 4.429233e-01 0.354 0 0
Platelet degranulation R-HSA-114608 4.455718e-01 0.351 0 0
Viral Infection Pathways R-HSA-9824446 4.466114e-01 0.350 0 0
Muscle contraction R-HSA-397014 4.476948e-01 0.349 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 4.504574e-01 0.346 0 0
Mitotic Anaphase R-HSA-68882 4.587114e-01 0.338 0 0
Signaling by FGFR2 in disease R-HSA-5655253 4.604511e-01 0.337 0 0
Azathioprine ADME R-HSA-9748787 4.604511e-01 0.337 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 4.614513e-01 0.336 0 0
Adherens junctions interactions R-HSA-418990 4.641853e-01 0.333 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 4.701966e-01 0.328 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 4.718307e-01 0.326 0 0
Neurexins and neuroligins R-HSA-6794361 4.718307e-01 0.326 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.774306e-01 0.321 0 0
Meiotic synapsis R-HSA-1221632 4.774306e-01 0.321 0 0
Regulation of PTEN stability and activity R-HSA-8948751 4.774306e-01 0.321 0 0
Smooth Muscle Contraction R-HSA-445355 4.774306e-01 0.321 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 4.873841e-01 0.312 0 0
Signaling by NOTCH3 R-HSA-9012852 4.884541e-01 0.311 0 0
Signaling by Hedgehog R-HSA-5358351 4.907801e-01 0.309 0 0
SARS-CoV-2-host interactions R-HSA-9705683 4.911835e-01 0.309 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 4.938475e-01 0.306 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 4.938788e-01 0.306 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 4.938788e-01 0.306 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 4.938788e-01 0.306 0 0
PTEN Regulation R-HSA-6807070 4.941620e-01 0.306 0 0
Dectin-2 family R-HSA-5621480 4.992463e-01 0.302 0 0
Macroautophagy R-HSA-1632852 5.008834e-01 0.300 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.098121e-01 0.293 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 5.098121e-01 0.293 0 0
Regulation of beta-cell development R-HSA-186712 5.098121e-01 0.293 0 0
Amino acid transport across the plasma membrane R-HSA-352230 5.098121e-01 0.293 0 0
Cell Cycle R-HSA-1640170 5.128605e-01 0.290 0 0
Regulation of PTEN gene transcription R-HSA-8943724 5.150117e-01 0.288 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 5.150117e-01 0.288 0 0
MAP kinase activation R-HSA-450294 5.201563e-01 0.284 0 0
Endogenous sterols R-HSA-211976 5.201563e-01 0.284 0 0
Formation of paraxial mesoderm R-HSA-9793380 5.201563e-01 0.284 0 0
Collagen degradation R-HSA-1442490 5.201563e-01 0.284 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 5.207024e-01 0.283 0 0
Heme signaling R-HSA-9707616 5.252468e-01 0.280 0 0
Mitochondrial protein import R-HSA-1268020 5.252468e-01 0.280 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.252468e-01 0.280 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.271919e-01 0.278 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 5.302835e-01 0.275 0 0
Gastrulation R-HSA-9758941 5.304145e-01 0.275 0 0
Xenobiotics R-HSA-211981 5.352671e-01 0.271 0 0
Interleukin-1 family signaling R-HSA-446652 5.399930e-01 0.268 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 5.401981e-01 0.267 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 5.450772e-01 0.264 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 5.463039e-01 0.263 0 0
HCMV Infection R-HSA-9609646 5.481160e-01 0.261 0 0
Cellular responses to stress R-HSA-2262752 5.482001e-01 0.261 0 0
DNA Double Strand Break Response R-HSA-5693606 5.499047e-01 0.260 0 0
Nicotinate metabolism R-HSA-196807 5.499047e-01 0.260 0 0
SLC-mediated transport of amino acids R-HSA-9958863 5.499047e-01 0.260 0 0
Cell-cell junction organization R-HSA-421270 5.506157e-01 0.259 0 0
Autophagy R-HSA-9612973 5.525545e-01 0.258 0 0
SARS-CoV-2 Infection R-HSA-9694516 5.525633e-01 0.258 0 0
Transcription of the HIV genome R-HSA-167172 5.546813e-01 0.256 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 5.546813e-01 0.256 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 5.587447e-01 0.253 0 0
Interleukin-17 signaling R-HSA-448424 5.640839e-01 0.249 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 5.640839e-01 0.249 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 5.640839e-01 0.249 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 5.687109e-01 0.245 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 5.687109e-01 0.245 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 5.687109e-01 0.245 0 0
ECM proteoglycans R-HSA-3000178 5.687109e-01 0.245 0 0
Retinoid metabolism and transport R-HSA-975634 5.687109e-01 0.245 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 5.732890e-01 0.242 0 0
Separation of Sister Chromatids R-HSA-2467813 5.769501e-01 0.239 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 5.778189e-01 0.238 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 5.823009e-01 0.235 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.911236e-01 0.228 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 5.974936e-01 0.224 0 0
Nuclear Receptor transcription pathway R-HSA-383280 5.997610e-01 0.222 0 0
RNA Polymerase I Transcription R-HSA-73864 5.997610e-01 0.222 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 5.997610e-01 0.222 0 0
Sensory processing of sound R-HSA-9659379 6.040114e-01 0.219 0 0
Ub-specific processing proteases R-HSA-5689880 6.060677e-01 0.217 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 6.060677e-01 0.217 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 6.060677e-01 0.217 0 0
Signaling by FGFR2 R-HSA-5654738 6.082169e-01 0.216 0 0
GPCR downstream signalling R-HSA-388396 6.116785e-01 0.213 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 6.123781e-01 0.213 0 0
Cell junction organization R-HSA-446728 6.149398e-01 0.211 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 6.164953e-01 0.210 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 6.205690e-01 0.207 0 0
Oncogenic MAPK signaling R-HSA-6802957 6.285878e-01 0.202 0 0
Meiosis R-HSA-1500620 6.285878e-01 0.202 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.285878e-01 0.202 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.325338e-01 0.199 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 6.364381e-01 0.196 0 0
Diseases of programmed cell death R-HSA-9645723 6.441235e-01 0.191 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 6.449580e-01 0.190 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 6.468724e-01 0.189 0 0
Downstream TCR signaling R-HSA-202424 6.516473e-01 0.186 0 0
Neurotransmitter release cycle R-HSA-112310 6.516473e-01 0.186 0 0
RNA Polymerase II Transcription R-HSA-73857 6.543194e-01 0.184 0 0
Toll-like Receptor Cascades R-HSA-168898 6.546229e-01 0.184 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.553497e-01 0.184 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 6.571763e-01 0.182 0 0
mRNA Splicing - Major Pathway R-HSA-72163 6.622382e-01 0.179 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 6.626375e-01 0.179 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 6.672402e-01 0.176 0 0
G alpha (i) signalling events R-HSA-418594 6.686979e-01 0.175 0 0
Scavenging of heme from plasma R-HSA-2168880 6.767567e-01 0.170 0 0
Co-inhibition by PD-1 R-HSA-389948 6.770660e-01 0.169 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 6.801937e-01 0.167 0 0
Potassium Channels R-HSA-1296071 6.801937e-01 0.167 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 6.835944e-01 0.165 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 6.835944e-01 0.165 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 6.869591e-01 0.163 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 6.869591e-01 0.163 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 6.869591e-01 0.163 0 0
Regulation of insulin secretion R-HSA-422356 6.869591e-01 0.163 0 0
Asparagine N-linked glycosylation R-HSA-446203 6.947250e-01 0.158 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 7.000660e-01 0.155 0 0
Opioid Signalling R-HSA-111885 7.064134e-01 0.151 0 0
Activation of HOX genes during differentiation R-HSA-5619507 7.095368e-01 0.149 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 7.095368e-01 0.149 0 0
RSV-host interactions R-HSA-9833110 7.095368e-01 0.149 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 7.126272e-01 0.147 0 0
SARS-CoV-1-host interactions R-HSA-9692914 7.156849e-01 0.145 0 0
Gene Silencing by RNA R-HSA-211000 7.187102e-01 0.143 0 0
Signaling by GPCR R-HSA-372790 7.196982e-01 0.143 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.217036e-01 0.142 0 0
Gene expression (Transcription) R-HSA-74160 7.233831e-01 0.141 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.246653e-01 0.140 0 0
Neddylation R-HSA-8951664 7.269640e-01 0.138 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.275956e-01 0.138 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.275956e-01 0.138 0 0
Antimicrobial peptides R-HSA-6803157 7.304949e-01 0.136 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 7.333636e-01 0.135 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 7.333636e-01 0.135 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.362019e-01 0.133 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 7.362019e-01 0.133 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 7.373582e-01 0.132 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.445378e-01 0.128 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 7.445378e-01 0.128 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 7.454305e-01 0.128 0 0
rRNA processing R-HSA-72312 7.493868e-01 0.125 0 0
Rab regulation of trafficking R-HSA-9007101 7.526118e-01 0.123 0 0
Mitochondrial biogenesis R-HSA-1592230 7.526118e-01 0.123 0 0
Chromatin modifying enzymes R-HSA-3247509 7.532906e-01 0.123 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 7.578530e-01 0.120 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 7.578530e-01 0.120 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 7.611820e-01 0.119 0 0
Signaling by NOTCH R-HSA-157118 7.646907e-01 0.117 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.655085e-01 0.116 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.655085e-01 0.116 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 7.680065e-01 0.115 0 0
Formation of the cornified envelope R-HSA-6809371 7.704781e-01 0.113 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 7.753429e-01 0.111 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 7.753429e-01 0.111 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 7.753429e-01 0.111 0 0
G1/S Transition R-HSA-69206 7.753429e-01 0.111 0 0
Metabolism of vitamins and cofactors R-HSA-196854 7.765932e-01 0.110 0 0
Chromatin organization R-HSA-4839726 7.809377e-01 0.107 0 0
Reproduction R-HSA-1474165 7.893307e-01 0.103 0 0
Deubiquitination R-HSA-5688426 7.912188e-01 0.102 0 0
Adipogenesis R-HSA-9843745 7.915763e-01 0.102 0 0
Cardiac conduction R-HSA-5576891 7.915763e-01 0.102 0 0
Generic Transcription Pathway R-HSA-212436 7.923410e-01 0.101 0 0
Circadian clock R-HSA-9909396 7.937981e-01 0.100 0 0
Degradation of the extracellular matrix R-HSA-1474228 7.937981e-01 0.100 0 0
Integration of energy metabolism R-HSA-163685 8.045589e-01 0.094 0 0
Metabolism of RNA R-HSA-8953854 8.087187e-01 0.092 0 0
Cellular response to chemical stress R-HSA-9711123 8.120528e-01 0.090 0 0
Late Phase of HIV Life Cycle R-HSA-162599 8.186923e-01 0.087 0 0
Visual phototransduction R-HSA-2187338 8.281609e-01 0.082 0 0
S Phase R-HSA-69242 8.299948e-01 0.081 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.324082e-01 0.080 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 8.336043e-01 0.079 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 8.353805e-01 0.078 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 8.371377e-01 0.077 0 0
Protein localization R-HSA-9609507 8.388763e-01 0.076 0 0
DNA Double-Strand Break Repair R-HSA-5693532 8.388763e-01 0.076 0 0
Transport of small molecules R-HSA-382551 8.405358e-01 0.075 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 8.405965e-01 0.075 0 0
PPARA activates gene expression R-HSA-1989781 8.422984e-01 0.075 0 0
HIV Life Cycle R-HSA-162587 8.456482e-01 0.073 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.456482e-01 0.073 0 0
Phospholipid metabolism R-HSA-1483257 8.495167e-01 0.071 0 0
Signaling by TGFB family members R-HSA-9006936 8.505407e-01 0.070 0 0
Regulation of TP53 Activity R-HSA-5633007 8.505407e-01 0.070 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 8.613653e-01 0.065 0 0
SLC transporter disorders R-HSA-5619102 8.613653e-01 0.065 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.686164e-01 0.061 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 8.700207e-01 0.060 0 0
SARS-CoV-1 Infection R-HSA-9678108 8.741448e-01 0.058 0 0
Respiratory electron transport R-HSA-611105 8.781387e-01 0.056 0 0
Cellular Senescence R-HSA-2559583 8.807311e-01 0.055 0 0
Epigenetic regulation of gene expression R-HSA-212165 8.811105e-01 0.055 0 0
TCF dependent signaling in response to WNT R-HSA-201681 8.845172e-01 0.053 0 0
Extracellular matrix organization R-HSA-1474244 8.889490e-01 0.051 0 0
GPCR ligand binding R-HSA-500792 8.912299e-01 0.050 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 8.980768e-01 0.047 0 0
Signaling by ROBO receptors R-HSA-376176 9.068785e-01 0.042 0 0
Keratinization R-HSA-6805567 9.108046e-01 0.041 0 0
Drug ADME R-HSA-9748784 9.216225e-01 0.035 0 0
HIV Infection R-HSA-162906 9.288704e-01 0.032 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.299375e-01 0.032 0 0
Interferon Signaling R-HSA-913531 9.299375e-01 0.032 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.381073e-01 0.028 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.426785e-01 0.026 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.589987e-01 0.018 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.632999e-01 0.016 0 0
Signaling by WNT R-HSA-195721 9.669811e-01 0.015 0 0
DNA Repair R-HSA-73894 9.831541e-01 0.007 0 0
Post-translational protein modification R-HSA-597592 9.872060e-01 0.006 0 0
Biological oxidations R-HSA-211859 9.971958e-01 0.001 0 0
Metabolism of proteins R-HSA-392499 9.995879e-01 0.000 0 0
Sensory Perception R-HSA-9709957 9.999859e-01 0.000 0 0
Metabolism of lipids R-HSA-556833 9.999914e-01 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 0.000 0 0
Signaling by LTK R-HSA-9842663 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.110223e-16 15.955 0 0
HSF1 activation R-HSA-3371511 1.110223e-16 15.955 0 0
Attenuation phase R-HSA-3371568 1.110223e-16 15.955 0 0
Cellular response to heat stress R-HSA-3371556 1.110223e-16 15.955 0 0
HSF1-dependent transactivation R-HSA-3371571 1.110223e-16 15.955 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.110223e-16 15.955 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.110223e-16 15.955 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.110223e-16 15.955 0 0
Cellular responses to stimuli R-HSA-8953897 1.110223e-16 15.955 0 0
Cellular responses to stress R-HSA-2262752 1.110223e-16 15.955 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 2.112754e-13 12.675 0 0
G2/M Checkpoints R-HSA-69481 2.982059e-13 12.525 0 0
HCMV Early Events R-HSA-9609690 4.076739e-13 12.390 0 0
Packaging Of Telomere Ends R-HSA-171306 5.838663e-13 12.234 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 5.838663e-13 12.234 0 0
Cell-Cell communication R-HSA-1500931 8.061329e-13 12.094 0 0
Cell Cycle R-HSA-1640170 8.932854e-13 12.049 0 0
M Phase R-HSA-68886 1.017741e-12 11.992 0 0
DNA methylation R-HSA-5334118 1.092237e-12 11.962 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.108114e-12 11.955 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.916245e-12 11.718 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 2.614908e-12 11.583 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 3.443357e-12 11.463 0 0
Infectious disease R-HSA-5663205 3.376521e-12 11.472 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 5.844547e-12 11.233 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 5.844547e-12 11.233 0 0
PKR-mediated signaling R-HSA-9833482 7.370438e-12 11.133 0 0
PRC2 methylates histones and DNA R-HSA-212300 9.663714e-12 11.015 0 0
L1CAM interactions R-HSA-373760 1.000278e-11 11.000 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 1.231404e-11 10.910 0 0
Cleavage of the damaged purine R-HSA-110331 1.231404e-11 10.910 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.286571e-11 10.891 0 0
Depurination R-HSA-73927 1.560230e-11 10.807 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.899536e-11 10.721 0 0
Meiotic synapsis R-HSA-1221632 2.184042e-11 10.661 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.184042e-11 10.661 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.250045e-11 10.648 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.464851e-11 10.608 0 0
HCMV Infection R-HSA-9609646 2.740697e-11 10.562 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 3.074663e-11 10.512 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 3.074663e-11 10.512 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 3.939948e-11 10.405 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.020217e-11 10.396 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.020217e-11 10.396 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 4.717104e-11 10.326 0 0
Depyrimidination R-HSA-73928 4.717104e-11 10.326 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 5.078715e-11 10.294 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.332590e-11 10.273 0 0
Defective pyroptosis R-HSA-9710421 5.803735e-11 10.236 0 0
Gap junction trafficking R-HSA-190828 7.110557e-11 10.148 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 7.470702e-11 10.127 0 0
Immune System R-HSA-168256 7.783296e-11 10.109 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 8.676260e-11 10.062 0 0
Nucleosome assembly R-HSA-774815 8.676260e-11 10.062 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.035798e-10 9.985 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.054534e-10 9.977 0 0
Recycling pathway of L1 R-HSA-437239 1.276880e-10 9.894 0 0
Viral Infection Pathways R-HSA-9824446 1.222045e-10 9.913 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.540494e-10 9.812 0 0
Cell junction organization R-HSA-446728 1.623190e-10 9.790 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.929561e-10 9.715 0 0
Gap junction trafficking and regulation R-HSA-157858 1.852024e-10 9.732 0 0
Cell Cycle, Mitotic R-HSA-69278 1.908824e-10 9.719 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.230144e-10 9.652 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.418545e-10 9.616 0 0
Meiotic recombination R-HSA-912446 2.650079e-10 9.577 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 3.154875e-10 9.501 0 0
Diseases of programmed cell death R-HSA-9645723 3.327315e-10 9.478 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.021834e-10 9.396 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 4.430890e-10 9.354 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 4.628087e-10 9.335 0 0
Aggrephagy R-HSA-9646399 5.002379e-10 9.301 0 0
HDACs deacetylate histones R-HSA-3214815 5.228301e-10 9.282 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 9.866588e-10 9.006 0 0
Adherens junctions interactions R-HSA-418990 1.182576e-09 8.927 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.149145e-09 8.940 0 0
Cell-cell junction organization R-HSA-421270 1.372482e-09 8.862 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.547822e-09 8.810 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.547822e-09 8.810 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.711832e-09 8.767 0 0
Axon guidance R-HSA-422475 1.813148e-09 8.742 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.862823e-09 8.730 0 0
Cell Cycle Checkpoints R-HSA-69620 2.069880e-09 8.684 0 0
Meiosis R-HSA-1500620 2.458196e-09 8.609 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 2.428571e-09 8.615 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.734792e-09 8.563 0 0
Gap junction assembly R-HSA-190861 2.861449e-09 8.543 0 0
DNA Double Strand Break Response R-HSA-5693606 3.136771e-09 8.504 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.590807e-09 8.445 0 0
Gene Silencing by RNA R-HSA-211000 3.761439e-09 8.425 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 4.678976e-09 8.330 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 5.182999e-09 8.285 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 5.182999e-09 8.285 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.182999e-09 8.285 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 4.676944e-09 8.330 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 4.678976e-09 8.330 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 5.326503e-09 8.274 0 0
Developmental Biology R-HSA-1266738 5.859188e-09 8.232 0 0
G2/M Transition R-HSA-69275 6.627957e-09 8.179 0 0
Nervous system development R-HSA-9675108 6.825245e-09 8.166 0 0
Mitotic G2-G2/M phases R-HSA-453274 7.580072e-09 8.120 0 0
Estrogen-dependent gene expression R-HSA-9018519 8.558232e-09 8.068 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 9.926314e-09 8.003 0 0
RNA Polymerase I Transcription R-HSA-73864 1.259124e-08 7.900 0 0
Telomere Maintenance R-HSA-157579 1.262600e-08 7.899 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.309397e-08 7.883 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.587687e-08 7.799 0 0
HATs acetylate histones R-HSA-3214847 1.540786e-08 7.812 0 0
Kinesins R-HSA-983189 1.613292e-08 7.792 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.779020e-08 7.750 0 0
Amyloid fiber formation R-HSA-977225 1.779020e-08 7.750 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.061796e-08 7.686 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.061796e-08 7.686 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.482351e-08 7.605 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.735744e-08 7.563 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.735744e-08 7.563 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 3.478673e-08 7.459 0 0
Selective autophagy R-HSA-9663891 4.215666e-08 7.375 0 0
Base Excision Repair R-HSA-73884 5.166984e-08 7.287 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 5.710664e-08 7.243 0 0
Cilium Assembly R-HSA-5617833 5.882071e-08 7.230 0 0
Mitotic Prometaphase R-HSA-68877 7.056888e-08 7.151 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 7.225818e-08 7.141 0 0
Assembly of the pre-replicative complex R-HSA-68867 7.659614e-08 7.116 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 9.028391e-08 7.044 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.086475e-07 6.964 0 0
Mitotic Prophase R-HSA-68875 1.277919e-07 6.893 0 0
Chromosome Maintenance R-HSA-73886 1.382540e-07 6.859 0 0
Signal Transduction R-HSA-162582 1.415425e-07 6.849 1 0
ESR-mediated signaling R-HSA-8939211 1.424835e-07 6.846 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.723871e-07 6.763 0 0
Membrane Trafficking R-HSA-199991 2.109640e-07 6.676 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.931593e-07 6.533 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.931593e-07 6.533 0 0
Autophagy R-HSA-9612973 2.940438e-07 6.532 0 0
Reproduction R-HSA-1474165 3.152150e-07 6.501 0 0
DNA Replication Pre-Initiation R-HSA-69002 3.728442e-07 6.428 0 0
Post NMDA receptor activation events R-HSA-438064 3.784729e-07 6.422 0 0
Chaperonin-mediated protein folding R-HSA-390466 3.784729e-07 6.422 0 0
Activation of BH3-only proteins R-HSA-114452 3.818000e-07 6.418 0 0
AURKA Activation by TPX2 R-HSA-8854518 4.123848e-07 6.385 0 0
Cytokine Signaling in Immune system R-HSA-1280215 4.698613e-07 6.328 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 5.112795e-07 6.291 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 5.522867e-07 6.258 0 0
Protein folding R-HSA-391251 6.517278e-07 6.186 0 0
EPH-Ephrin signaling R-HSA-2682334 6.517278e-07 6.186 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 7.051224e-07 6.152 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 7.168005e-07 6.145 0 0
Disease R-HSA-1643685 7.556192e-07 6.122 0 0
Adaptive Immune System R-HSA-1280218 7.769068e-07 6.110 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 8.648670e-07 6.063 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 9.905489e-07 6.004 0 0
Smooth Muscle Contraction R-HSA-445355 1.053907e-06 5.977 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.981442e-07 6.001 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 9.981442e-07 6.001 0 0
Homology Directed Repair R-HSA-5693538 8.650619e-07 6.063 0 0
Centrosome maturation R-HSA-380287 1.054998e-06 5.977 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.054998e-06 5.977 0 0
Protein ubiquitination R-HSA-8852135 1.054998e-06 5.977 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.172104e-06 5.931 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.519421e-06 5.818 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.519421e-06 5.818 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.519421e-06 5.818 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.522728e-06 5.817 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.617694e-06 5.791 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.426584e-06 5.615 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.948856e-06 5.530 0 0
Semaphorin interactions R-HSA-373755 3.201886e-06 5.495 0 0
Vesicle-mediated transport R-HSA-5653656 3.486409e-06 5.458 0 0
Chromatin modifying enzymes R-HSA-3247509 3.558989e-06 5.449 0 0
Co-inhibition by PD-1 R-HSA-389948 3.639213e-06 5.439 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 3.870235e-06 5.412 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.917077e-06 5.407 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 4.365430e-06 5.360 0 0
Signaling by NOTCH R-HSA-157118 4.632153e-06 5.334 0 0
Macroautophagy R-HSA-1632852 4.758740e-06 5.323 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 4.933222e-06 5.307 0 0
Ub-specific processing proteases R-HSA-5689880 5.197300e-06 5.284 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 5.473734e-06 5.262 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 5.763015e-06 5.239 0 0
Hemostasis R-HSA-109582 6.238335e-06 5.205 0 0
Chromatin organization R-HSA-4839726 6.783333e-06 5.169 0 0
Intraflagellar transport R-HSA-5620924 6.859732e-06 5.164 0 0
ER to Golgi Anterograde Transport R-HSA-199977 7.123793e-06 5.147 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 7.385778e-06 5.132 0 0
Cellular Senescence R-HSA-2559583 7.420499e-06 5.130 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 7.614258e-06 5.118 0 0
MHC class II antigen presentation R-HSA-2132295 8.638266e-06 5.064 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 9.027383e-06 5.044 0 0
DNA Double-Strand Break Repair R-HSA-5693532 9.908998e-06 5.004 0 0
DNA Replication R-HSA-69306 9.908998e-06 5.004 0 0
Signaling by WNT R-HSA-195721 1.008668e-05 4.996 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.045523e-05 4.981 0 0
Interleukin-12 signaling R-HSA-9020591 1.074891e-05 4.969 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.667156e-05 4.778 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.609988e-05 4.793 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.740087e-05 4.759 0 0
Regulation of CDH1 Function R-HSA-9764561 1.776358e-05 4.750 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.227603e-05 4.652 0 0
Interleukin-12 family signaling R-HSA-447115 2.764610e-05 4.558 0 0
Muscle contraction R-HSA-397014 3.307045e-05 4.481 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.462525e-05 4.461 0 0
Signaling by RAF1 mutants R-HSA-9656223 3.532099e-05 4.452 0 0
Deubiquitination R-HSA-5688426 3.893889e-05 4.410 0 0
Interferon Signaling R-HSA-913531 4.191691e-05 4.378 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 5.767103e-05 4.239 0 0
Signaling downstream of RAS mutants R-HSA-9649948 6.017945e-05 4.221 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 6.017945e-05 4.221 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 6.017945e-05 4.221 0 0
Signaling by RAS mutants R-HSA-6802949 6.017945e-05 4.221 0 0
Signaling by VEGF R-HSA-194138 6.452573e-05 4.190 0 0
HCMV Late Events R-HSA-9610379 6.721804e-05 4.173 0 0
Gluconeogenesis R-HSA-70263 7.336875e-05 4.134 0 0
Neutrophil degranulation R-HSA-6798695 8.925484e-05 4.049 0 0
Separation of Sister Chromatids R-HSA-2467813 9.250316e-05 4.034 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 9.646726e-05 4.016 0 0
Protein methylation R-HSA-8876725 9.646726e-05 4.016 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.863554e-05 4.006 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 1.517948e-04 3.819 0 0
Parasite infection R-HSA-9664407 1.517948e-04 3.819 0 0
Leishmania phagocytosis R-HSA-9664417 1.517948e-04 3.819 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.639967e-04 3.785 0 0
Mitotic Anaphase R-HSA-68882 1.736396e-04 3.760 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.800157e-04 3.745 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 1.987734e-04 3.702 0 0
Nef and signal transduction R-HSA-164944 1.990219e-04 3.701 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.994483e-04 3.700 0 0
Innate Immune System R-HSA-168249 2.169342e-04 3.664 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.262624e-04 3.645 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.643274e-04 3.578 0 0
DNA Repair R-HSA-73894 2.652429e-04 3.576 0 0
Platelet activation, signaling and aggregation R-HSA-76002 2.959704e-04 3.529 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.037239e-04 3.518 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 3.361841e-04 3.473 0 0
Leishmania infection R-HSA-9658195 3.647762e-04 3.438 0 0
Parasitic Infection Pathways R-HSA-9824443 3.647762e-04 3.438 0 0
MAP2K and MAPK activation R-HSA-5674135 3.690708e-04 3.433 0 0
Platelet degranulation R-HSA-114608 3.950698e-04 3.403 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.006516e-04 3.397 0 0
Apoptosis R-HSA-109581 4.096349e-04 3.388 0 0
Hedgehog 'off' state R-HSA-5610787 4.714810e-04 3.327 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.824227e-04 3.317 0 0
Programmed Cell Death R-HSA-5357801 4.932778e-04 3.307 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 5.404297e-04 3.267 0 0
CASP4 inflammasome assembly R-HSA-9948001 5.787402e-04 3.238 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 6.231494e-04 3.205 0 0
SARS-CoV-1 Infection R-HSA-9678108 6.957267e-04 3.158 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 9.549891e-04 3.020 0 0
Signaling by Interleukins R-HSA-449147 1.015460e-03 2.993 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.126845e-03 2.948 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 1.248866e-03 2.903 0 0
Integrin signaling R-HSA-354192 1.417872e-03 2.848 0 0
Non-canonical inflammasome activation R-HSA-9686114 1.469336e-03 2.833 0 0
Striated Muscle Contraction R-HSA-390522 1.554302e-03 2.808 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.712778e-03 2.766 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.980019e-03 2.703 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.589000e-03 2.587 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.854093e-03 2.732 0 0
Glycolysis R-HSA-70171 2.572291e-03 2.590 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.725799e-03 2.565 0 0
Generic Transcription Pathway R-HSA-212436 2.757125e-03 2.560 0 0
Generation of second messenger molecules R-HSA-202433 2.774283e-03 2.557 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.989882e-03 2.524 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.002962e-03 2.522 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.057492e-03 2.515 0 0
Signaling by Hedgehog R-HSA-5358351 3.131332e-03 2.504 0 0
Transmission across Chemical Synapses R-HSA-112315 3.481676e-03 2.458 0 0
Signal transduction by L1 R-HSA-445144 3.699372e-03 2.432 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.240979e-03 2.373 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 4.424149e-03 2.354 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 4.646030e-03 2.333 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 4.744264e-03 2.324 0 0
SARS-CoV Infections R-HSA-9679506 4.926714e-03 2.307 0 0
RNA Polymerase II Transcription R-HSA-73857 5.536037e-03 2.257 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 5.554888e-03 2.255 0 0
Syndecan interactions R-HSA-3000170 5.573473e-03 2.254 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.573473e-03 2.254 0 0
Glucose metabolism R-HSA-70326 5.703515e-03 2.244 0 0
MAPK family signaling cascades R-HSA-5683057 5.712078e-03 2.243 0 0
SARS-CoV-2 Infection R-HSA-9694516 5.939632e-03 2.226 0 0
Deadenylation of mRNA R-HSA-429947 6.115858e-03 2.214 0 0
CHL1 interactions R-HSA-447041 6.803528e-03 2.167 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 6.803528e-03 2.167 0 0
Post-translational protein modification R-HSA-597592 7.297174e-03 2.137 0 0
Translation initiation complex formation R-HSA-72649 7.302061e-03 2.137 0 0
Interaction between L1 and Ankyrins R-HSA-445095 7.927466e-03 2.101 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 8.137844e-03 2.089 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 8.137844e-03 2.089 0 0
Formation of annular gap junctions R-HSA-196025 8.167082e-03 2.088 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 9.034056e-03 2.044 0 0
Gap junction degradation R-HSA-190873 9.642613e-03 2.016 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 9.642613e-03 2.016 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 1.122724e-02 1.950 0 0
FOXO-mediated transcription R-HSA-9614085 1.165704e-02 1.933 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 1.200546e-02 1.921 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.413041e-02 1.850 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.447609e-02 1.839 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.609888e-02 1.793 0 0
Gene expression (Transcription) R-HSA-74160 1.613629e-02 1.792 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.636546e-02 1.786 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.660769e-02 1.780 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.712700e-02 1.766 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.712700e-02 1.766 0 0
TCR signaling R-HSA-202403 1.743880e-02 1.758 0 0
Metabolism of proteins R-HSA-392499 1.759841e-02 1.755 0 0
Potential therapeutics for SARS R-HSA-9679191 1.764279e-02 1.753 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 1.808990e-02 1.743 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 1.915452e-02 1.718 0 0
Asparagine N-linked glycosylation R-HSA-446203 2.065853e-02 1.685 0 0
Signal regulatory protein family interactions R-HSA-391160 2.068967e-02 1.684 0 0
Sensory processing of sound R-HSA-9659379 2.245605e-02 1.649 0 0
DCC mediated attractive signaling R-HSA-418885 2.287128e-02 1.641 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.405086e-02 1.619 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.405086e-02 1.619 0 0
Defective Mismatch Repair Associated With MSH3 R-HSA-5632927 2.405086e-02 1.619 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.750311e-02 1.561 0 0
Extracellular matrix organization R-HSA-1474244 2.905682e-02 1.537 0 0
Signaling by Hippo R-HSA-2028269 2.994841e-02 1.524 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 3.026821e-02 1.519 0 0
Ephrin signaling R-HSA-3928664 3.247676e-02 1.488 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 3.508582e-02 1.455 0 0
Rap1 signalling R-HSA-392517 3.508582e-02 1.455 0 0
The NLRP3 inflammasome R-HSA-844456 3.508582e-02 1.455 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.585959e-02 1.445 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.585959e-02 1.445 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.585959e-02 1.445 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.585959e-02 1.445 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.585959e-02 1.445 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.585959e-02 1.445 0 0
Eukaryotic Translation Elongation R-HSA-156842 3.696697e-02 1.432 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 3.762647e-02 1.425 0 0
Nephrin family interactions R-HSA-373753 3.777329e-02 1.423 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.777329e-02 1.423 0 0
Neuronal System R-HSA-112316 3.819611e-02 1.418 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 4.053690e-02 1.392 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 4.752615e-02 1.323 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.752615e-02 1.323 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 4.752615e-02 1.323 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 4.752615e-02 1.323 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 4.752615e-02 1.323 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 4.752615e-02 1.323 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 4.752615e-02 1.323 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 4.752615e-02 1.323 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 4.752615e-02 1.323 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 4.752615e-02 1.323 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 4.752615e-02 1.323 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 4.752615e-02 1.323 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 8.168980e-02 1.088 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 4.628376e-02 1.335 0 0
MET activates PTK2 signaling R-HSA-8874081 5.859655e-02 1.232 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 6.010010e-02 1.221 0 0
Cap-dependent Translation Initiation R-HSA-72737 7.561369e-02 1.121 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 6.183348e-02 1.209 0 0
DAP12 signaling R-HSA-2424491 7.189410e-02 1.143 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 5.905226e-02 1.229 0 0
Eukaryotic Translation Initiation R-HSA-72613 7.561369e-02 1.121 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 4.752615e-02 1.323 0 0
MET interacts with TNS proteins R-HSA-8875513 5.905226e-02 1.229 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 7.043959e-02 1.152 0 0
Suppression of autophagy R-HSA-9636569 8.168980e-02 1.088 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 4.931343e-02 1.307 0 0
mTORC1-mediated signalling R-HSA-166208 4.628376e-02 1.335 0 0
Diseases of Cellular Senescence R-HSA-9630747 4.752615e-02 1.323 0 0
Diseases of cellular response to stress R-HSA-9675132 4.752615e-02 1.323 0 0
NADE modulates death signalling R-HSA-205025 7.043959e-02 1.152 0 0
Laminin interactions R-HSA-3000157 5.542112e-02 1.256 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 6.010010e-02 1.221 0 0
Developmental Cell Lineages R-HSA-9734767 5.942349e-02 1.226 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 7.043959e-02 1.152 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 6.183348e-02 1.209 0 0
Molecules associated with elastic fibres R-HSA-2129379 7.535804e-02 1.123 0 0
Signaling by NOTCH4 R-HSA-9013694 7.947711e-02 1.100 0 0
Inflammasomes R-HSA-622312 6.512998e-02 1.186 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.581233e-02 1.339 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 5.542112e-02 1.256 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 7.189410e-02 1.143 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 7.726220e-02 1.112 0 0
Neurodegenerative Diseases R-HSA-8863678 5.230916e-02 1.281 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 5.230916e-02 1.281 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 4.759031e-02 1.322 1 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 6.183348e-02 1.209 0 0
Sema4D in semaphorin signaling R-HSA-400685 5.542112e-02 1.256 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 5.859655e-02 1.232 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 6.687884e-02 1.175 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 8.860857e-02 1.053 0 0
RAF activation R-HSA-5673000 8.971834e-02 1.047 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 8.971834e-02 1.047 0 0
eNOS activation R-HSA-203615 8.971834e-02 1.047 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 9.280454e-02 1.032 0 0
Signaling by MAPK mutants R-HSA-9652817 9.280454e-02 1.032 0 0
Cam-PDE 1 activation R-HSA-111957 9.280454e-02 1.032 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 9.280454e-02 1.032 0 0
Signaling by MET R-HSA-6806834 9.333270e-02 1.030 0 0
GPVI-mediated activation cascade R-HSA-114604 9.717748e-02 1.012 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.717748e-02 1.012 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 1.037854e-01 0.984 0 0
MET promotes cell motility R-HSA-8875878 1.048053e-01 0.980 0 0
Elastic fibre formation R-HSA-1566948 1.048053e-01 0.980 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 1.086786e-01 0.964 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.146341e-01 0.941 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 1.146341e-01 0.941 0 0
FLT3 Signaling R-HSA-9607240 1.165366e-01 0.934 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.205183e-01 0.919 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.210389e-01 0.917 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.237198e-01 0.908 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.245333e-01 0.905 0 0
MTOR signalling R-HSA-165159 1.245333e-01 0.905 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.245333e-01 0.905 0 0
Type I hemidesmosome assembly R-HSA-446107 1.253521e-01 0.902 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.253521e-01 0.902 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.253521e-01 0.902 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.253521e-01 0.902 0 0
Response of Mtb to phagocytosis R-HSA-9637690 1.285802e-01 0.891 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.285802e-01 0.891 0 0
Bacterial Infection Pathways R-HSA-9824439 1.309242e-01 0.883 0 0
DAP12 interactions R-HSA-2172127 1.326577e-01 0.877 0 0
Netrin-1 signaling R-HSA-373752 1.326577e-01 0.877 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.326577e-01 0.877 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.347397e-01 0.871 0 0
Lipophagy R-HSA-9613354 1.359410e-01 0.867 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.359410e-01 0.867 0 0
Calcineurin activates NFAT R-HSA-2025928 1.359410e-01 0.867 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.359410e-01 0.867 0 0
ARMS-mediated activation R-HSA-170984 1.359410e-01 0.867 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 1.359410e-01 0.867 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.408990e-01 0.851 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 1.408990e-01 0.851 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 1.408990e-01 0.851 0 0
Apoptotic execution phase R-HSA-75153 1.408990e-01 0.851 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.457111e-01 0.837 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.464023e-01 0.834 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 1.464023e-01 0.834 0 0
Regulation of CDH11 function R-HSA-9762292 1.464023e-01 0.834 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.464023e-01 0.834 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.464023e-01 0.834 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.513986e-01 0.820 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.567376e-01 0.805 0 0
Ionotropic activity of kainate receptors R-HSA-451306 1.567376e-01 0.805 0 0
vRNP Assembly R-HSA-192905 1.567376e-01 0.805 0 0
PECAM1 interactions R-HSA-210990 1.567376e-01 0.805 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 1.567376e-01 0.805 0 0
Interleukin-2 signaling R-HSA-9020558 1.567376e-01 0.805 0 0
Dissolution of Fibrin Clot R-HSA-75205 1.567376e-01 0.805 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.571561e-01 0.804 0 0
Azathioprine ADME R-HSA-9748787 1.576922e-01 0.802 0 0
Metabolism of RNA R-HSA-8953854 1.621337e-01 0.790 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.662247e-01 0.779 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.669485e-01 0.777 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 1.669485e-01 0.777 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 1.669485e-01 0.777 0 0
Sodium/Calcium exchangers R-HSA-425561 1.669485e-01 0.777 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 1.669485e-01 0.777 0 0
Activation of RAC1 R-HSA-428540 1.669485e-01 0.777 0 0
RSV-host interactions R-HSA-9833110 1.688693e-01 0.772 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.705209e-01 0.768 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.705209e-01 0.768 0 0
Scavenging by Class F Receptors R-HSA-3000484 1.770363e-01 0.752 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.770363e-01 0.752 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.770363e-01 0.752 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.770363e-01 0.752 0 0
Pervasive developmental disorders R-HSA-9005895 1.770363e-01 0.752 0 0
Disorders of Nervous System Development R-HSA-9697154 1.770363e-01 0.752 0 0
NRAGE signals death through JNK R-HSA-193648 1.835165e-01 0.736 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.870025e-01 0.728 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.870025e-01 0.728 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.870025e-01 0.728 0 0
Frs2-mediated activation R-HSA-170968 1.870025e-01 0.728 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.870025e-01 0.728 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.870025e-01 0.728 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 1.870025e-01 0.728 0 0
FCERI mediated MAPK activation R-HSA-2871796 1.930071e-01 0.714 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 1.968487e-01 0.706 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.968487e-01 0.706 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.968487e-01 0.706 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 1.968487e-01 0.706 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.065762e-01 0.685 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.065762e-01 0.685 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 2.065762e-01 0.685 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.065762e-01 0.685 0 0
Other semaphorin interactions R-HSA-416700 2.065762e-01 0.685 0 0
Leishmania parasite growth and survival R-HSA-9664433 2.073851e-01 0.683 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 2.073851e-01 0.683 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 2.085092e-01 0.681 0 0
Mitochondrial protein import R-HSA-1268020 2.098967e-01 0.678 0 0
NCAM signaling for neurite out-growth R-HSA-375165 2.098967e-01 0.678 0 0
Prolonged ERK activation events R-HSA-169893 2.161865e-01 0.665 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 2.161865e-01 0.665 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 2.161865e-01 0.665 0 0
Negative regulation of FLT3 R-HSA-9706369 2.161865e-01 0.665 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 2.187774e-01 0.660 0 0
Influenza Infection R-HSA-168255 2.225965e-01 0.652 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.256810e-01 0.647 0 0
Fibronectin matrix formation R-HSA-1566977 2.256810e-01 0.647 0 0
Disorders of Developmental Biology R-HSA-9675151 2.256810e-01 0.647 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.350611e-01 0.629 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.350611e-01 0.629 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 2.350611e-01 0.629 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 2.350611e-01 0.629 0 0
Uptake and function of anthrax toxins R-HSA-5210891 2.350611e-01 0.629 0 0
Host Interactions of HIV factors R-HSA-162909 2.370592e-01 0.625 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.411040e-01 0.618 0 0
Mismatch Repair R-HSA-5358508 2.443281e-01 0.612 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.443281e-01 0.612 0 0
PKA activation R-HSA-163615 2.443281e-01 0.612 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.443281e-01 0.612 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.443281e-01 0.612 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 2.467267e-01 0.608 0 0
ECM proteoglycans R-HSA-3000178 2.500678e-01 0.602 0 0
Metabolism of cofactors R-HSA-8978934 2.500678e-01 0.602 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.534834e-01 0.596 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 2.534834e-01 0.596 0 0
Regulation of signaling by CBL R-HSA-912631 2.534834e-01 0.596 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.545538e-01 0.594 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 2.545538e-01 0.594 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 2.625283e-01 0.581 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.625283e-01 0.581 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 2.625283e-01 0.581 0 0
Negative regulation of MET activity R-HSA-6807004 2.625283e-01 0.581 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.635303e-01 0.579 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.714642e-01 0.566 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.714642e-01 0.566 0 0
G-protein activation R-HSA-202040 2.714642e-01 0.566 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 2.714642e-01 0.566 0 0
Basigin interactions R-HSA-210991 2.714642e-01 0.566 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.802924e-01 0.552 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.802924e-01 0.552 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 2.802924e-01 0.552 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.802924e-01 0.552 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.802924e-01 0.552 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.802924e-01 0.552 0 0
Ribavirin ADME R-HSA-9755088 2.802924e-01 0.552 0 0
Integrin cell surface interactions R-HSA-216083 2.814828e-01 0.551 0 0
G alpha (12/13) signalling events R-HSA-416482 2.814828e-01 0.551 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 2.859105e-01 0.544 0 0
FGFR2 alternative splicing R-HSA-6803529 2.890141e-01 0.539 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 2.890141e-01 0.539 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 2.890141e-01 0.539 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 2.890141e-01 0.539 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.890141e-01 0.539 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.904486e-01 0.537 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 2.976307e-01 0.526 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 2.976307e-01 0.526 0 0
Formation of the ureteric bud R-HSA-9830674 2.976307e-01 0.526 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.976307e-01 0.526 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 3.061434e-01 0.514 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.061434e-01 0.514 0 0
Mitochondrial RNA degradation R-HSA-9836573 3.061434e-01 0.514 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.061434e-01 0.514 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 3.090333e-01 0.510 0 0
Translation R-HSA-72766 3.092107e-01 0.510 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 3.127944e-01 0.505 0 0
Long-term potentiation R-HSA-9620244 3.145534e-01 0.502 0 0
Tight junction interactions R-HSA-420029 3.145534e-01 0.502 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 3.145534e-01 0.502 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 3.145534e-01 0.502 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 3.145534e-01 0.502 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 3.145534e-01 0.502 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 3.145534e-01 0.502 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.216939e-01 0.493 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.228620e-01 0.491 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 3.228620e-01 0.491 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 3.228620e-01 0.491 0 0
Peptide chain elongation R-HSA-156902 3.305651e-01 0.481 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.310704e-01 0.480 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.310704e-01 0.480 0 0
Cristae formation R-HSA-8949613 3.310704e-01 0.480 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 3.391798e-01 0.470 0 0
Formation of the Early Elongation Complex R-HSA-113418 3.391798e-01 0.470 0 0
HIV elongation arrest and recovery R-HSA-167287 3.391798e-01 0.470 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.391798e-01 0.470 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 3.391798e-01 0.470 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 3.391798e-01 0.470 0 0
Protein localization R-HSA-9609507 3.454463e-01 0.462 0 0
Late endosomal microautophagy R-HSA-9615710 3.471913e-01 0.459 0 0
mRNA Capping R-HSA-72086 3.471913e-01 0.459 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 3.471913e-01 0.459 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.471913e-01 0.459 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.471913e-01 0.459 0 0
DARPP-32 events R-HSA-180024 3.471913e-01 0.459 0 0
Platelet calcium homeostasis R-HSA-418360 3.471913e-01 0.459 0 0
IRE1alpha activates chaperones R-HSA-381070 3.482077e-01 0.458 0 0
Death Receptor Signaling R-HSA-73887 3.487530e-01 0.457 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 3.520581e-01 0.453 0 0
HIV Infection R-HSA-162906 3.542078e-01 0.451 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.551063e-01 0.450 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.551063e-01 0.450 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 3.551063e-01 0.450 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.551063e-01 0.450 0 0
FCGR activation R-HSA-2029481 3.569721e-01 0.447 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 3.569721e-01 0.447 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 3.600894e-01 0.444 0 0
Mitochondrial protein degradation R-HSA-9837999 3.613387e-01 0.442 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 3.629257e-01 0.440 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 3.629257e-01 0.440 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 3.656944e-01 0.437 0 0
Signaling by TGFB family members R-HSA-9006936 3.685517e-01 0.434 0 0
Formation of a pool of free 40S subunits R-HSA-72689 3.700387e-01 0.432 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.706509e-01 0.431 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.706509e-01 0.431 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 3.743713e-01 0.427 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.782828e-01 0.422 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.782828e-01 0.422 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.782828e-01 0.422 0 0
Regulation of necroptotic cell death R-HSA-5675482 3.782828e-01 0.422 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.782828e-01 0.422 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 3.858226e-01 0.414 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 3.932715e-01 0.405 0 0
Regulation of Apoptosis R-HSA-169911 4.006304e-01 0.397 0 0
Signalling to ERKs R-HSA-187687 4.006304e-01 0.397 0 0
Oncogene Induced Senescence R-HSA-2559585 4.006304e-01 0.397 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 4.077928e-01 0.390 0 0
CaM pathway R-HSA-111997 4.079006e-01 0.389 0 0
Calmodulin induced events R-HSA-111933 4.079006e-01 0.389 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 4.079006e-01 0.389 0 0
FGFR2 mutant receptor activation R-HSA-1839126 4.079006e-01 0.389 0 0
Opioid Signalling R-HSA-111885 4.085715e-01 0.389 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 4.150830e-01 0.382 0 0
Nucleotide Excision Repair R-HSA-5696398 4.169822e-01 0.380 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 4.221788e-01 0.375 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 4.291889e-01 0.367 0 0
RAS processing R-HSA-9648002 4.291889e-01 0.367 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.361143e-01 0.360 0 0
HIV Transcription Elongation R-HSA-167169 4.361143e-01 0.360 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.361143e-01 0.360 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 4.361143e-01 0.360 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 4.361143e-01 0.360 0 0
Glycogen metabolism R-HSA-8982491 4.361143e-01 0.360 0 0
Interleukin-2 family signaling R-HSA-451927 4.361143e-01 0.360 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 4.429562e-01 0.354 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 4.429562e-01 0.354 0 0
PKMTs methylate histone lysines R-HSA-3214841 4.429562e-01 0.354 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 4.497155e-01 0.347 0 0
HIV Transcription Initiation R-HSA-167161 4.497155e-01 0.347 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 4.497155e-01 0.347 0 0
Ca-dependent events R-HSA-111996 4.563932e-01 0.341 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 4.629902e-01 0.334 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 4.661191e-01 0.332 0 0
Cyclin D associated events in G1 R-HSA-69231 4.695076e-01 0.328 0 0
G1 Phase R-HSA-69236 4.695076e-01 0.328 0 0
RMTs methylate histone arginines R-HSA-3214858 4.695076e-01 0.328 0 0
Proteasome assembly R-HSA-9907900 4.695076e-01 0.328 0 0
Mitochondrial biogenesis R-HSA-1592230 4.740717e-01 0.324 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 4.759463e-01 0.322 0 0
DAG and IP3 signaling R-HSA-1489509 4.759463e-01 0.322 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.759463e-01 0.322 0 0
mRNA Splicing - Major Pathway R-HSA-72163 4.806930e-01 0.318 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 4.823072e-01 0.317 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.823072e-01 0.317 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 4.823072e-01 0.317 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 4.823072e-01 0.317 0 0
Diseases of DNA repair R-HSA-9675135 4.823072e-01 0.317 0 0
Regulation of pyruvate metabolism R-HSA-9861718 4.823072e-01 0.317 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 4.897614e-01 0.310 0 0
GPER1 signaling R-HSA-9634597 4.947996e-01 0.306 0 0
Co-stimulation by CD28 R-HSA-389356 4.947996e-01 0.306 0 0
Metal ion SLC transporters R-HSA-425410 4.947996e-01 0.306 0 0
Degradation of CDH1 R-HSA-9766229 5.009328e-01 0.300 0 0
Signaling by FGFR2 in disease R-HSA-5655253 5.069920e-01 0.295 0 0
Infection with Enterobacteria R-HSA-9640148 5.080843e-01 0.294 0 0
The phototransduction cascade R-HSA-2514856 5.129779e-01 0.290 0 0
Branched-chain amino acid catabolism R-HSA-70895 5.129779e-01 0.290 0 0
mRNA Splicing R-HSA-72172 5.140700e-01 0.289 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 5.188916e-01 0.285 0 0
Nucleotide biosynthesis R-HSA-8956320 5.247338e-01 0.280 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 5.305054e-01 0.275 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.418403e-01 0.266 0 0
Ion homeostasis R-HSA-5578775 5.418403e-01 0.266 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 5.418403e-01 0.266 0 0
Dectin-2 family R-HSA-5621480 5.474052e-01 0.262 0 0
Nuclear Envelope Breakdown R-HSA-2980766 5.474052e-01 0.262 0 0
Dual incision in TC-NER R-HSA-6782135 5.529028e-01 0.257 0 0
Metabolism of non-coding RNA R-HSA-194441 5.583341e-01 0.253 0 0
snRNP Assembly R-HSA-191859 5.583341e-01 0.253 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 5.583341e-01 0.253 0 0
Signaling by ERBB2 R-HSA-1227986 5.636996e-01 0.249 0 0
Unfolded Protein Response (UPR) R-HSA-381119 5.671473e-01 0.246 0 0
PLC beta mediated events R-HSA-112043 5.690003e-01 0.245 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.690003e-01 0.245 0 0
Endogenous sterols R-HSA-211976 5.690003e-01 0.245 0 0
Ion transport by P-type ATPases R-HSA-936837 5.845211e-01 0.233 0 0
Xenobiotics R-HSA-211981 5.845211e-01 0.233 0 0
Cellular response to hypoxia R-HSA-1234174 5.895701e-01 0.229 0 0
G-protein mediated events R-HSA-112040 5.994857e-01 0.222 0 0
Kidney development R-HSA-9830369 5.994857e-01 0.222 0 0
Metabolism of nucleotides R-HSA-15869 6.042030e-01 0.219 0 0
Transcription of the HIV genome R-HSA-167172 6.043538e-01 0.219 0 0
Regulated Necrosis R-HSA-5218859 6.043538e-01 0.219 0 0
Cell surface interactions at the vascular wall R-HSA-202733 6.068372e-01 0.217 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 6.138778e-01 0.212 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.139140e-01 0.212 0 0
COPII-mediated vesicle transport R-HSA-204005 6.139140e-01 0.212 0 0
Ca2+ pathway R-HSA-4086398 6.278250e-01 0.202 0 0
Signaling by FGFR in disease R-HSA-1226099 6.323503e-01 0.199 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 6.326979e-01 0.199 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 6.368209e-01 0.196 0 0
ISG15 antiviral mechanism R-HSA-1169408 6.368209e-01 0.196 0 0
UCH proteinases R-HSA-5689603 6.412373e-01 0.193 0 0
Signaling by FGFR2 R-HSA-5654738 6.583752e-01 0.182 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 6.625308e-01 0.179 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 6.710165e-01 0.173 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 6.746984e-01 0.171 0 0
Amplification of signal from the kinetochores R-HSA-141424 6.825665e-01 0.166 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 6.825665e-01 0.166 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.825665e-01 0.166 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 6.825665e-01 0.166 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 6.864293e-01 0.163 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 6.864293e-01 0.163 0 0
Pyruvate metabolism R-HSA-70268 6.902454e-01 0.161 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 7.014185e-01 0.154 0 0
Neurotransmitter release cycle R-HSA-112310 7.014185e-01 0.154 0 0
Downstream TCR signaling R-HSA-202424 7.014185e-01 0.154 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 7.050530e-01 0.152 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 7.068258e-01 0.151 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 7.086435e-01 0.150 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 7.186787e-01 0.143 0 0
Collagen formation R-HSA-1474290 7.191562e-01 0.143 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 7.225758e-01 0.141 0 0
Eukaryotic Translation Termination R-HSA-72764 7.259541e-01 0.139 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 7.292914e-01 0.137 0 0
Post-translational protein phosphorylation R-HSA-8957275 7.358452e-01 0.133 0 0
Signaling by FGFR R-HSA-190236 7.358452e-01 0.133 0 0
Mitotic Spindle Checkpoint R-HSA-69618 7.422411e-01 0.129 0 0
Selenocysteine synthesis R-HSA-2408557 7.453810e-01 0.128 0 0
Viral mRNA Translation R-HSA-192823 7.515472e-01 0.124 0 0
Signaling by ROBO receptors R-HSA-376176 7.538591e-01 0.123 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 7.545744e-01 0.122 0 0
Platelet homeostasis R-HSA-418346 7.634374e-01 0.117 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 7.663204e-01 0.116 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 7.663204e-01 0.116 0 0
Signaling by ALK in cancer R-HSA-9700206 7.663204e-01 0.116 0 0
Stimuli-sensing channels R-HSA-2672351 7.691684e-01 0.114 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 7.802193e-01 0.108 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 7.802193e-01 0.108 0 0
Inositol phosphate metabolism R-HSA-1483249 7.802193e-01 0.108 0 0
Drug ADME R-HSA-9748784 7.871597e-01 0.104 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 7.881606e-01 0.103 0 0
Interferon alpha/beta signaling R-HSA-909733 7.932955e-01 0.101 0 0
Rab regulation of trafficking R-HSA-9007101 7.983066e-01 0.098 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 8.077053e-01 0.093 0 0
rRNA processing R-HSA-72312 8.129954e-01 0.090 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 8.173639e-01 0.088 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 8.259338e-01 0.083 0 0
Cardiac conduction R-HSA-5576891 8.342788e-01 0.079 0 0
Circadian clock R-HSA-9909396 8.363021e-01 0.078 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.460558e-01 0.073 0 0
Ribosome-associated quality control R-HSA-9948299 8.497934e-01 0.071 0 0
Late Phase of HIV Life Cycle R-HSA-162599 8.587470e-01 0.066 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 8.655260e-01 0.063 0 0
Visual phototransduction R-HSA-2187338 8.671695e-01 0.062 0 0
Signaling by NTRKs R-HSA-166520 8.687931e-01 0.061 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 8.719812e-01 0.059 0 0
MITF-M-dependent gene expression R-HSA-9856651 8.719812e-01 0.059 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 8.750922e-01 0.058 0 0
Phase I - Functionalization of compounds R-HSA-211945 8.793087e-01 0.056 0 0
PPARA activates gene expression R-HSA-1989781 8.796183e-01 0.056 0 0
HIV Life Cycle R-HSA-162587 8.825446e-01 0.054 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.825446e-01 0.054 0 0
Cellular response to starvation R-HSA-9711097 8.839811e-01 0.054 0 0
Regulation of TP53 Activity R-HSA-5633007 8.868019e-01 0.052 0 0
Selenoamino acid metabolism R-HSA-2408522 8.922405e-01 0.050 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 8.961480e-01 0.048 0 0
G alpha (s) signalling events R-HSA-418555 9.023499e-01 0.045 0 0
Respiratory electron transport R-HSA-611105 9.104181e-01 0.041 0 0
Peptide ligand-binding receptors R-HSA-375276 9.188297e-01 0.037 0 0
Ion channel transport R-HSA-983712 9.217773e-01 0.035 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.489393e-01 0.023 0 0
Signaling by GPCR R-HSA-372790 9.589246e-01 0.018 0 0
GPCR downstream signalling R-HSA-388396 9.671848e-01 0.014 0 0
G alpha (i) signalling events R-HSA-418594 9.676526e-01 0.014 0 0
Cellular response to chemical stress R-HSA-9711123 9.709041e-01 0.013 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.755407e-01 0.011 0 0
Intracellular signaling by second messengers R-HSA-9006925 9.883961e-01 0.005 0 0
Biological oxidations R-HSA-211859 9.906737e-01 0.004 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.931265e-01 0.003 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.940088e-01 0.003 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.942292e-01 0.003 0 0
GPCR ligand binding R-HSA-500792 9.955001e-01 0.002 0 0
Diseases of metabolism R-HSA-5668914 9.960347e-01 0.002 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.967465e-01 0.001 0 0
Sensory Perception R-HSA-9709957 9.995257e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999966e-01 0.000 0 0
Metabolism R-HSA-1430728 9.999998e-01 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Signaling by LTK R-HSA-9842663 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways