TAK1

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A5A3E0 T949 Sugiyama POTEF A26C1B TVAsSSSLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
A5A3E0 Y1062 Sugiyama POTEF A26C1B GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCL_______
A5A3E0 Y940 Sugiyama POTEF A26C1B ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
A6NKT7 T1210 Sugiyama RGPD3 RGP3 KLIQRAEEMKSGLKDFKTFLtNDQTKVAEEENKGSGTGAAG
O00299 Y233 Sugiyama CLIC1 G6 NCC27 AyAREEFAstCPDDEEIELAyEQVAKALK____________
O00429 Y101 Sugiyama DNM1L DLP1 DRP1 EENGVEAEEWGKFLHTKNKLyTDFDEIRQEIENETERISGN
O00469 Y444 Sugiyama PLOD2 LWSNFWGALSPDGYYARsEDyVDIVQGNRVGVWNVPYMANV
O00571 S71 Sugiyama DDX3X DBX DDX3 GFyDKDSSGWsssKDKDAyssFGsRsDsRGKssFFsDRGsG
O14715 T1209 Sugiyama RGPD8 RANBP2ALPHA RANBP2L1 RANBP2L3 KLIQRAEEMKSGLKDFKTFLtNDQTKVTEEENKGsGTGVAG
O14818 T152 Sugiyama PSMA7 HSPC LIVGFDFDGTPRLyQtDPsGtyHAWKANAIGRGAKSVREFL
O14920 S177 SIGNOR|EPSD|PSP IKBKB IKKB EQRLIHKIIDLGYAKELDQGsLCTsFVGTLQyLAPELLEQQ
O14920 S181 SIGNOR|EPSD|PSP IKBKB IKKB IHKIIDLGYAKELDQGsLCTsFVGTLQyLAPELLEQQKyTV
O14950 Y156 Sugiyama MYL12B MRLC2 MYLC2B DEEVDELyREAPIDKKGNFNyIEFtRILKHGAKDKDD____
O15067 S227 Sugiyama PFAS KIAA0361 FQELQRNPstVEAFDLAQsNsEHSRHWFFKGQLHVDGQKLV
O15371 T49 Sugiyama EIF3D EIF3S7 PyQPFsKGDRLGKVADWtGAtyQDKRYTNKYSSQFGGGSQY
O15523 S71 Sugiyama DDX3Y DBY GFHDKDSSGWSCSKDKDAyssFGsRDSRGKPGYFSERGSGS
O43318 S192 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP MAP3K7 TAK1 KICDFGtACDIQtHMtNNKGsAAWMAPEVFEGSNySEKCDV
O43318 T178 SIGNOR|EPSD|PSP MAP3K7 TAK1 KPPNLLLVAGGTVLKICDFGtACDIQtHMtNNKGsAAWMAP
O43318 T184 SIGNOR|ELM|iPTMNet|EPSD|PSP MAP3K7 TAK1 LVAGGTVLKICDFGtACDIQtHMtNNKGsAAWMAPEVFEGS
O43318 T187 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP MAP3K7 TAK1 GGTVLKICDFGtACDIQtHMtNNKGsAAWMAPEVFEGSNyS
O43390 T137 Sugiyama HNRNPR HNRPR ESTKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVYS
O43423 T101 Sugiyama ANP32CP PP32R1 EKCPNLTHLYLSGNKIKDLstIEPLKQLENLKSLDLFNCEV
O43707 T445 Sugiyama ACTN4 HEAWtDGKEAMLKHRDyEtAtLsDIKALIRKHEAFEsDLAA
O43707 Y212 Sugiyama ACTN4 WKDGLAFNALIHRHRPELIEyDKLRKDDPVTNLNNAFEVAE
O43707 Y441 Sugiyama ACTN4 KAsIHEAWtDGKEAMLKHRDyEtAtLsDIKALIRKHEAFEs
O43707 Y906 Sugiyama ACTN4 yQGPDAVPGALDyKsFStALyGEsDL_______________
O43852 T196 Sugiyama CALU FtAFLHPEEyDyMKDIVVQEtMEDIDKNADGFIDLEEyIGD
O43852 Y106 Sugiyama CALU GFVtVDELKDWIKFAQKRWIyEDVERQWKGHDLNEDGLVsW
O43852 Y263 Sugiyama CALU KNRDGKMDKEEtKDWILPsDyDHAEAEARHLVyEsDQNKDG
O60361 Y136 Sugiyama NME2P1 SLRFKPEELVDYKSCAHDWVyE___________________
O60506 T134 Sugiyama SYNCRIP HNRPQ NSAP1 DSSKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVYS
O60664 Y95 Sugiyama PLIN3 M6PRBP1 TIP47 VsGAQPILSKLEPQIAsAsEyAHRGLDKLEENLPILQQPTE
O75347 Y75 Sugiyama TBCA EILQEsRMMIPDCQRRLEAAyLDLQRILENEKDLEEAEEyK
O75369 S905 Sugiyama FLNB FLN1L FLN3 TABP TAP NsPLPGDAVKDLDIIDNyDysHtVKYtPtQQGNMQVLVTYG
O75369 T907 Sugiyama FLNB FLN1L FLN3 TABP TAP PLPGDAVKDLDIIDNyDysHtVKYtPtQQGNMQVLVTYGGD
O75369 Y902 Sugiyama FLNB FLN1L FLN3 TABP TAP VQFNsPLPGDAVKDLDIIDNyDysHtVKYtPtQQGNMQVLV
O75506 T29 Sugiyama HSBP1 HSF1BP VQDLTSVVQTLLQQMQDKFQtMsDQIIGRIDDMSSRIDDLE
O94776 Y437 Sugiyama MTA2 MTA1L1 PID tTEPHSRGHLsRPEAQsLsPyttsANRAKLLAKNRQtFLLQ
O94992 Y274 Sugiyama HEXIM1 CLP1 EDG1 HIS1 MAQ1 GMGGDGSEFLQRDFsEtyERyHTEsLQNMsKQELIKEyLEL
O95626 T105 Sugiyama ANP32D PP32R2 EKCPNLIHLNLSGNKIKDLstIEPLKKLENLESLDLFTCEV
O95757 T365 Sugiyama HSPA4L APG1 HSPH3 OSP94 TRIPAVKEQITKFFLKDISTtLNADEAVARGCALQCAILsP
P00338 T3 EPSD|PSP LDHA PIG19 __________________MAtLKDQLIyNLLKEEQtPQNKI
P00338 T322 Sugiyama LDHA PIG19 DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P00338 Y239 Sugiyama LDHA PIG19 GtDKDKEQWKEVHKQVVEsAyEVIKLKGYtSWAIGLSVADL
P00390 T365 Sugiyama GSR GLUR GRD1 NKLGIQTDDKGHIIVDEFQNtNVKGIyAVGDVCGKALLtPV
P00558 T168 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 EAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGF
P00558 Y161 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 KAEPAKIEAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNL
P02786 T143 Sugiyama TFRC yWDDLKRKLsEKLDstDFTGtIKLLNENsyVPREAGsQKDE
P04040 T28 Sugiyama CAT ASDQMQHWKEQRAAQKADVLttGAGNPVGDKLNVItVGPRG
P04040 T29 Sugiyama CAT SDQMQHWKEQRAAQKADVLttGAGNPVGDKLNVItVGPRGP
P04075 S336 Sugiyama ALDOA ALDA GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075 T119 Sugiyama ALDOA ALDA KsKGGVVGIKVDKGVVPLAGtNGEtttQGLDGLsERCAQYK
P04075 T123 Sugiyama ALDOA ALDA GVVGIKVDKGVVPLAGtNGEtttQGLDGLsERCAQYKKDGA
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04075 Y364 Sugiyama ALDOA ALDA tPsGQAGAAAsEsLFVsNHAy____________________
P04083 T169 Sugiyama ANXA1 ANX1 LPC1 IRDINRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRs
P04083 T24 Sugiyama ANXA1 ANX1 LPC1 VsEFLKQAWFIENEEQEyVQtVKssKGGPGsAVsPyPtFNP
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T211 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 PsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtGM
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05787 Y286 Sugiyama KRT8 CYK8 QyEDIANRsRAEAEsMyQIKyEELQsLAGKHGDDLRRTKTE
P06733 S268 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 ASEFFRsGKyDLDFKsPDDPsRyIsPDQLADLyKsFIKDyP
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06733 T26 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 IHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEA
P06733 Y270 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 EFFRsGKyDLDFKsPDDPsRyIsPDQLADLyKsFIKDyPVV
P06733 Y280 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 DFKsPDDPsRyIsPDQLADLyKsFIKDyPVVsIEDPFDQDD
P06733 Y44 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P07195 T18 Sugiyama LDHB ___MATLKEKLIAPVAEEEAtVPNNKITVVGVGQVGMACAI
P07205 T168 Sugiyama PGK2 PGKB EAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNLPHKASGF
P07205 Y161 Sugiyama PGK2 PGKB KAEPDKIEAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNL
P07205 Y196 Sugiyama PGK2 PGKB MVGVNLPHKASGFLMKKELDyFAKALENPVRPFLAILGGAK
P07237 Y94 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB GSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNGDTASPK
P07355 Y188 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D RKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVKRKGT
P07437 S75 Sugiyama TUBB TUBB5 OK/SW-cl.56 tGGKyVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
P07437 T166 EPSD|PSP TUBB TUBB5 OK/SW-cl.56 GMGTLLISKIREEYPDRIMNtFsVVPsPKVSDTVVEPYNAT
P07437 T55 Sugiyama TUBB TUBB5 OK/SW-cl.56 tyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEPGtMDs
P07437 Y50 Sugiyama TUBB TUBB5 OK/SW-cl.56 IDPTGtyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEP
P07437 Y51 Sugiyama TUBB TUBB5 OK/SW-cl.56 DPTGtyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEPG
P07814 Y1504 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 KPLCELQPGAKCVCGKNPAKyytLFGRsy____________
P07814 Y1505 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 PLCELQPGAKCVCGKNPAKyytLFGRsy_____________
P07814 Y827 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 EIGQNIssNssAsILESKsLyDEVAAQGEVVRKLKAEKSPK
P07858 T218 Sugiyama CTSB CPSB CTGEGDTPKCSKICEPGysPtyKQDKHYGYNSYSVSNSEKD
P07900 S165 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGTK
P07900 S52 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900 S53 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P07900 T305 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IDQEELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLA
P07900 T317 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA WtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P07900 T467 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LGIHEDsQNRKKLsELLRyytsAsGDEMVsLKDYCTRMKEN
P07900 Y160 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA SAYLVAEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGEPM
P07900 Y197 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA GEPMGRGTKVILHLKEDQtEyLEERRIKEIVKKHSQFIGyP
P07900 Y284 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DEEEEKKDGDKKKKKKIKEKyIDQEELNKtKPIWtRNPDDI
P07900 Y309 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA ELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHF
P07900 Y492 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DEMVsLKDYCTRMKENQKHIyyItGETKDQVANsAFVERLR
P07900 Y493 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA EMVsLKDYCTRMKENQKHIyyItGETKDQVANsAFVERLRK
P08195 T321 Sugiyama SLC3A2 MDU1 SIRVILDLTPNYRGENSWFStQVDtVATKVKDALEFWLQAG
P08195 T599 Sugiyama SLC3A2 MDU1 QASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEPH
P08238 S160 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB AEKVVVITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGTK
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 T309 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB WtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08238 T459 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB LGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEt
P08238 T467 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB NRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyIt
P08238 T637 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MGyMMAKKHLEINPDHPIVEtLRQKAEADKNDKAVKDLVVL
P08238 T85 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB LDsGKELKIDIIPNPQERtLtLVDtGIGMtKADLINNLGtI
P08238 T89 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB KELKIDIIPNPQERtLtLVDtGIGMtKADLINNLGtIAKSG
P08238 Y155 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB SAYLVAEKVVVITKHNDDEQyAWEssAGGsFtVRADHGEPI
P08238 Y192 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB GEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIGyP
P08238 Y276 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DEEDDsGKDKKKKTKKIKEKyIDQEELNKtKPIWtRNPDDI
P08238 Y301 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB ELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHF
P08238 Y305 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB tKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEG
P08238 Y484 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DEMtsLsEyVsRMKEtQKsIyyItGEsKEQVANsAFVERVR
P08238 Y485 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB EMtsLsEyVsRMKEtQKsIyyItGEsKEQVANsAFVERVRK
P08708 Y84 Sugiyama RPS17 RPS17L GPVRGISIKLQEEERERRDNyVPEVsALDQEIIEVDPDtKE
P09234 T11 Sugiyama SNRPC __________MPKFyCDyCDtyLtHDsPsVRKTHCSGRKHK
P09234 T14 Sugiyama SNRPC _______MPKFyCDyCDtyLtHDsPsVRKTHCSGRKHKENV
P09234 Y12 Sugiyama SNRPC _________MPKFyCDyCDtyLtHDsPsVRKTHCSGRKHKE
P09382 T58 Sugiyama LGALS1 DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P0CG38 Y1062 Sugiyama POTEI GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCF_______
P0CG39 Y1025 Sugiyama POTEJ GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCF_______
P0DJD0 T1194 Sugiyama RGPD1 RANBP2L6 RGP1 KLIQRAEEMKSGLKDFKTFLtNDQTKVTEEENKGsGtGAAG
P0DPH7 T334 Sugiyama TUBA3C TUBA2 ACCMLYRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
P0DPH7 T56 Sugiyama TUBA3C TUBA2 MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVVD
P10809 T113 Sugiyama HSPD1 HSP60 IGAKLVQDVANNtNEEAGDGtttAtVLARSIAKEGFEKISK
P10809 T231 Sugiyama HSPD1 HSP60 LEIIEGMKFDRGyIsPyFINtsKGQKCEFQDAyVLLsEKKI
P10809 Y243 Sugiyama HSPD1 HSP60 yIsPyFINtsKGQKCEFQDAyVLLsEKKIssIQsIVPALEI
P11142 T163 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142 T427 Sugiyama HSPA8 HSC70 HSP73 HSPA10 GGVMTVLIKRNtTIPTKQtQtFttysDNQPGVLIQVyEGER
P11142 T64 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FtDtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQ
P11142 T66 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P11142 Y41 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P11940 T191 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 GRFKSRKEREAELGARAKEFtNVyIKNFGEDMDDERLKDLF
P11940 Y291 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 ERQTELKRKFEQMKQDRITRyQGVNLyVKNLDDGIDDERLR
P11940 Y297 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 KRKFEQMKQDRITRyQGVNLyVKNLDDGIDDERLRKEFsPF
P12277 Y125 Sugiyama CKB CKBB EHKTDLNPDNLQGGDDLDPNyVLssRVRTGRSIRGFCLPPH
P12814 Y422 Sugiyama ACTN1 KAsIHEAWtDGKEAMLRQKDyEtAtLsEIKALLKKHEAFEs
P13489 S290 Sugiyama RNH1 PRI RNH AKGCGDLCRVLRAKESLKELsLAGNELGDEGARLLCETLLE
P13489 T176 Sugiyama RNH1 PRI RNH AASCEPLASVLRAKPDFKELtVsNNDINEAGVRVLCQGLKD
P13639 S38 Sugiyama EEF2 EF2 NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13639 S587 Sugiyama EEF2 EF2 CIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKAR
P13639 T34 Sugiyama EEF2 EF2 DKKANIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEt
P13639 T36 Sugiyama EEF2 EF2 KANIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRF
P13639 T484 Sugiyama EEF2 EF2 VPCGNIVGLVGVDQFLVKtGtIttFEHAHNMRVMKFsVsPV
P13639 Y443 Sugiyama EEF2 EF2 TGLKVRIMGPNytPGKKEDLyLKPIQRTILMMGRYVEPIED
P13667 T449 Sugiyama PDIA4 ERP70 ERP72 AATQFWRSKVLEVAKDFPEytFAIADEEDyAGEVKDLGLsE
P13667 Y458 Sugiyama PDIA4 ERP70 ERP72 VLEVAKDFPEytFAIADEEDyAGEVKDLGLsEsGEDVNAAI
P13987 T85 Sugiyama CD59 MIC11 MIN1 MIN2 MIN3 MSK21 WKFEHCNFNDVtTRLRENELtyyCCKKDLCNFNEQLENGGT
P14314 T469 Sugiyama PRKCSH G19P1 WGsWIGPDHDKFSAMKyEQGtGCWQGPNRstTVRLLCGKEt
P14618 T50 Sugiyama PKM OIP3 PK2 PK3 PKM2 MCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMIKsGMN
P14618 T87 Sugiyama PKM OIP3 PK2 PK3 PKM2 sGMNVARLNFsHGtHEyHAEtIKNVRtAtEsFAsDPILyRP
P14625 S674 EPSD|PSP HSP90B1 GRP94 HSPC4 TRA1 WsGNMERIMKAQAYQtGKDIstNyyAsQKKTFEINPRHPLI
P14625 T669 EPSD|PSP HSP90B1 GRP94 HSPC4 TRA1 AsQyGWsGNMERIMKAQAYQtGKDIstNyyAsQKKTFEINP
P14625 T675 EPSD|PSP HSP90B1 GRP94 HSPC4 TRA1 sGNMERIMKAQAYQtGKDIstNyyAsQKKTFEINPRHPLIR
P15153 T161 Sugiyama RAC2 QGLALAKEIDSVKyLECsALtQRGLKtVFDEAIRAVLCPQP
P15311 T533 Sugiyama EZR VIL2 NEEKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDII
P15880 Y248 Sugiyama RPS2 RPS4 GCtAtLGNFAKATFDAISKTysyLtPDLWKEtVFtKsPyQE
P15880 Y250 Sugiyama RPS2 RPS4 tAtLGNFAKATFDAISKTysyLtPDLWKEtVFtKsPyQEFt
P17066 T228 Sugiyama HSPA6 HSP70B' DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P17066 Y43 Sugiyama HSPA6 HSP70B' FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P17812 S575 Sugiyama CTPS1 CTPS LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P17812 Y468 Sugiyama CTPS1 CTPS MRLGKRRtLFQTKNsVMRKLyGDADyLEERHRHRFEVNPVW
P17812 Y473 Sugiyama CTPS1 CTPS RRtLFQTKNsVMRKLyGDADyLEERHRHRFEVNPVWKKCLE
P17980 Y381 Sugiyama PSMC3 TBP1 ARARIMQIHSRKMNVsPDVNyEELARCTDDFNGAQCKAVCV
P17987 S551 Sugiyama TCP1 CCT1 CCTA IKLHPESKDDKHGsyEDAVHsGALND_______________
P17987 Y545 Sugiyama TCP1 CCT1 CCTA LRIDDLIKLHPESKDDKHGsyEDAVHsGALND_________
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P18669 T146 Sugiyama PGAM1 PGAMA CDABP0006 MEPDHPFysNIsKDRRyADLtEDQLPsCEsLKDtIARALPF
P18669 Y142 Sugiyama PGAM1 PGAMA CDABP0006 PPPPMEPDHPFysNIsKDRRyADLtEDQLPsCEsLKDtIAR
P19105 Y155 Sugiyama MYL12A MLCB MRLC3 RLC DEEVDELyREAPIDKKGNFNyIEFtRILKHGAKDKDD____
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P20618 Y150 Sugiyama PSMB1 PSC5 FPYYVYNIIGGLDEEGKGAVysFDPVGsyQRDsFKAGGSAS
P21333 T1286 EPSD|PSP FLNA FLN FLN1 EGQGVFREATTEFSVDARALtQtGGPHVKARVANPsGNLTE
P22234 Y22 Sugiyama PAICS ADE2 AIRC PAIS AtAEVLNIGKKLYEGKtKEVyELLDsPGKVLLQsKDQItAG
P22314 T1016 Sugiyama UBA1 A1S9T UBE1 MLYSFFMPAAKLKERLDQPMtEIVsRVSKRKLGRHVRALVL
P22314 T233 Sugiyama UBA1 A1S9T UBE1 GEQPLSAMVSMVTKDNPGVVtCLDEARHGFESGDFVSFSEV
P22314 Y55 Sugiyama UBA1 A1S9T UBE1 SVPTNGMAKNGsEADIDEGLysRQLyVLGHEAMKRLQTSSV
P22392 Y151 Sugiyama NME2 NM23B SLWFKPEELVDyKSCAHDWVyE___________________
P22626 T176 EPSD|PSP HNRNPA2B1 HNRPA2B1 GFVtFDDHDPVDKIVLQKyHtINGHNAEVRKALsRQEMQEV
P23284 T108 Sugiyama PPIB CYPB YKNSKFHRVIKDFMIQGGDFtRGDGtGGKsIyGERFPDENF
P23434 Y139 Sugiyama GCSH EVTEINEALAENPGLVNKSCyEDGWLIKMtLsNPsELDELM
P23526 Y193 Sugiyama AHCY SAHH LKVPAINVNDsVtKsKFDNLyGCRESLIDGIKRATDVMIAG
P23528 T63 Sugiyama CFL1 CFL DKKNIILEEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyA
P23528 T70 Sugiyama CFL1 CFL EEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyALyDAtyE
P23528 Y140 Sugiyama CFL1 CFL SKDAIKKKLtGIKHELQANCyEEVKDRCTLAEKLGGsAVIs
P23528 Y85 Sugiyama CFL1 CFL DDPyAtFVKMLPDKDCRyALyDAtyEtKESKKEDLVFIFWA
P23528 Y89 Sugiyama CFL1 CFL AtFVKMLPDKDCRyALyDAtyEtKESKKEDLVFIFWAPESA
P23588 S230 EPSD|PSP EIF4B DyPPRRGDDsFGDKYRDRYDsDRYRDGYRDGYRDGPRRDMD
P23921 T555 Sugiyama RRM1 RR1 IyyGALEASCDLAKEQGPyEtyEGsPVsKGILQYDMWNVTP
P23921 Y553 Sugiyama RRM1 RR1 EtIyyGALEASCDLAKEQGPyEtyEGsPVsKGILQYDMWNV
P24752 Y214 Sugiyama ACAT1 ACAT MAT GsCAENTAKKLNIARNEQDAyAINsytRSKAAWEAGKFGNE
P25398 Y127 Sugiyama RPS12 sCVVVKDYGKESQAKDVIEEyFKCKK_______________
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P26045 S359 SIGNOR|EPSD|PSP PTPN3 PTPH1 QYCKKVIGGMVWNPAMRRsLsVEHLEtKsLPsRsPPItPNW
P26196 Y469 Sugiyama DDX6 HLR2 RCK IEEQLGTEIKPIPsNIDKSLyVAEyHsEPVEDEKP______
P26196 Y473 Sugiyama DDX6 HLR2 RCK LGTEIKPIPsNIDKSLyVAEyHsEPVEDEKP__________
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26639 S522 Sugiyama TARS1 TARS PEKFLGDIEVWDQAEKQLENsLNEFGEKWELNsGDGAFyGP
P27348 T30 Sugiyama YWHAQ AKLAEQAERyDDMAtCMKAVtEQGAELsNEERNLLsVAyKN
P27348 Y149 Sugiyama YWHAQ LAEVACGDDRKQtIDNsQGAyQEAFDIsKKEMQPTHPIRLG
P27695 Y45 Sugiyama APEX1 APE APE1 APEX APX HAP1 REF1 KSKTAAKKNDKEAAGEGPALyEDPPDQKtsPsGKPAtLKIC
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P27797 Y109 Sugiyama CALR CRTC QTLVVQFTVKHEQNIDCGGGyVKLFPNSLDQTDMHGDSEYN
P28066 T14 Sugiyama PSMA5 _______MFLTRsEyDRGVNtFsPEGRLFQVEyAIEAIKLG
P29322 Y651 Sugiyama EPHA8 EEK HEK3 KIAA1459 EASRIHIEKIIGsGDSGEVCyGRLRVPGQRDVPVAIKALKA
P29322 Y750 Sugiyama EPHA8 EEK HEK3 KIAA1459 GQFTIMQLVGMLRGVGAGMRyLsDLGyVHRDLAARNVLVDS
P29322 Y756 Sugiyama EPHA8 EEK HEK3 KIAA1459 QLVGMLRGVGAGMRyLsDLGyVHRDLAARNVLVDSNLVCKV
P29322 Y793 Sugiyama EPHA8 EEK HEK3 KIAA1459 VCKVSDFGLsRVLEDDPDAAyTTtGGKIPIRWTAPEAIAFR
P29401 T454 Sugiyama TKT LAMFRsVPtstVFyPsDGVAtEKAVELAANTKGICFIRTsR
P29692 T147 Sugiyama EEF1D EF1D PQtQHVsPMRQVEPPAKKPAtPAEDDEDDDIDLFGsDNEEE
P29692 Y26 Sugiyama EEF1D EF1D LAHEKIWFDKFKYDDAERRFyEQMNGPVAGAsRQENGAsVI
P30043 T199 Sugiyama BLVRB FLR SCAN HDLGHFMLRCLttDEyDGHstyPsHQyQ_____________
P30086 S139 Sugiyama PEBP1 PBP PEBP RyVWLVyEQDRPLKCDEPILsNRsGDHRGKFKVAsFRKKyE
P30086 T65 Sugiyama PEBP1 PBP PEBP QVKNRPtsIsWDGLDsGKLytLVLtDPDAPsRKDPKYREWH
P30086 Y64 Sugiyama PEBP1 PBP PEBP tQVKNRPtsIsWDGLDsGKLytLVLtDPDAPsRKDPKYREW
P30101 T485 Sugiyama PDIA3 ERP57 ERP60 GRP58 KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P30101 Y115 Sugiyama PDIA3 ERP57 ERP60 GRP58 yGVsGyPtLKIFRDGEEAGAyDGPRtADGIVsHLKKQAGPA
P30101 Y67 Sugiyama PDIA3 ERP57 ERP60 GRP58 LMLVEFFAPWCGHCKRLAPEyEAAAtRLKGIVPLAKVDCTA
P30307 S216 PSP CDC25C EFsLKDQEAKVSRsGLYRsPsMPENLNRPRLKQVEKFKDNt
P30533 S242 Sugiyama LRPAP1 A2MRAP TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P30533 T248 Sugiyama LRPAP1 A2MRAP LRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWDLAQSAN
P31153 Y242 Sugiyama MAT2A AMS2 MATA2 LKEKVIKAVVPAKyLDEDtIyHLQPsGRFVIGGPQGDAGLt
P31327 T326 Sugiyama CPS1 AKTYKMSMANRGQNQPVLNItNKQAFITAQNHGYALDNTLP
P31327 Y1450 Sugiyama CPS1 GsIDLVINLPNNNTKFVHDNyVIRRTAVDSGIPLLTNFQVT
P31943 Y266 Sugiyama HNRNPH1 HNRPH HNRPH1 yNGYNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGstFQst
P31946 S39 Sugiyama YWHAB ERyDDMAAAMKAVtEQGHELsNEERNLLsVAyKNVVGARRS
P31946 Y151 Sugiyama YWHAB LsEVAsGDNKQTtVsNsQQAyQEAFEIsKKEMQPTHPIRLG
P31948 Y354 Sugiyama STIP1 DVLKKCQQAEKILKEQERLAyINPDLALEEKNKGNECFQKG
P32119 T142 Sugiyama PRDX2 NKEFB TDPX1 EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P32969 Y180 Sugiyama RPL9 OK/SW-cl.103; RPL9P7; RPL9P8; RPL9P9 LIQQATTVKNKDIRKFLDGIyVsEKGtVQQADE________
P33121 T695 Sugiyama ACSL1 FACL1 FACL2 LACS LACS1 LACS2 KAKRPELRNYFRSQIDDLyStIKV_________________
P33176 T182 Sugiyama KIF5B KNS KNS1 VPYVKGCTERFVCsPDEVMDtIDEGKSNRHVAVTNMNEHSS
P34931 T228 Sugiyama HSPA1L DVSILTIDDGIFEVKAtAGDtHLGGEDFDNRLVsHFVEEFK
P34931 Y43 Sugiyama HSPA1L FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P34932 S31 Sugiyama HSPA4 APG2 HSPH2 QSCYVAVARAGGIETIANEysDRCtPACIsFGPKNRSIGAA
P34932 T364 Sugiyama HSPA4 APG2 HSPH2 ATRIPAVKEKISKFFGKELsttLNADEAVTRGCALQCAILs
P35080 T85 Sugiyama PFN2 tLGAKKCSVIRDSLyVDGDCtMDIRTKsQGGEPTyNVAVGR
P35269 T154 Sugiyama GTF2F1 RAP74 AFEAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHF
P35579 T1151 Sugiyama MYH9 EKQKRDLGEELEALKtELEDtLDstAAQQELRSKREQEVNI
P36871 Y476 Sugiyama PGM1 GKQFSANDKVYtVEKADNFEysDPVDGsIsRNQGLRLIFTD
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P38159 T216 EPSD|PSP RBMX HNRPG RBMXP1 REPLPSRRDVYLsPRDDGystKDsyssRDYPSSRDTRDYAP
P38646 T116 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646 T398 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P39019 T36 Sugiyama RPS19 RALAAFLKKSGKLKVPEWVDtVKLAKHKELAPyDENWFytR
P39019 Y48 Sugiyama RPS19 LKVPEWVDtVKLAKHKELAPyDENWFytRAAstARHLYLRG
P39019 Y54 Sugiyama RPS19 VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39687 T105 Sugiyama ANP32A C15orf1 LANP MAPM PHAP1 EKCPNLTHLNLsGNKIKDLstIEPLKKLENLKsLDLFNCEV
P41091 T21 Sugiyama EIF2S3 EIF2G MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
P42166 T160 Sugiyama TMPO LAP2 KLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsNDs
P42167 T160 Sugiyama TMPO LAP2 KLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSNDS
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46013 T1919 Sugiyama MKI67 SAGKAMHTPKAAVGEEKDINtFVGtPVEKLDLLGNLPGsKR
P46459 T19 Sugiyama NSF __MAGRSMQAARCPTDELsLtNCAVVNEKDFQsGQHVIVRT
P46777 Y226 Sugiyama RPL5 MSTP030 DyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAHAA
P47756 T202 Sugiyama CAPZB SGsGtMNLGGsLtRQMEKDEtVsDCsPHIANIGRLVEDMEN
P47756 Y59 Sugiyama CAPZB LLSSVDQPLKIARDKVVGKDyLLCDyNRDGDSyRsPWSNKy
P48741 T228 Sugiyama HSPA7 HSP70B DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P48741 Y43 Sugiyama HSPA7 HSP70B FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P49005 T33 EPSD|PSP POLD2 LLsPPSANNATFARVPVATYtNSSQPFRLGERSFSRQYAHI
P49327 T1999 Sugiyama FASN FAS LLENQTPEFFQDVCKPKYsGtLNLDRVTREACPELDYFVVF
P49327 Y2034 Sugiyama FASN FAS DYFVVFSSVSCGRGNAGQsNyGFANsAMERICEKRRHEGLP
P49327 Y277 Sugiyama FASN FAS KEQGVtFPsGDIQEQLIRSLyQsAGVAPEsFEyIEAHGtGT
P49327 Y289 Sugiyama FASN FAS QEQLIRSLyQsAGVAPEsFEyIEAHGtGTKVGDPQELNGIt
P49327 Y45 Sugiyama FASN FAS NLIGGVDMVTDDDRRWKAGLyGLPRRsGKLKDLSRFDAsFF
P49736 Y234 Sugiyama MCM2 BM28 CCNL1 CDCL1 KIAA0030 VFKERIsDMCKENREsLVVNyEDLAAREHVLAYFLPEAPAE
P49792 T2185 Sugiyama RANBP2 NUP358 KLIQRAEEMKSGLKDFKTFLtNDQTKVTEEENKGsGtGAAG
P50395 T205 Sugiyama GDI2 RABGDIB TGHALALYRtDDyLDQPCyEtINRIKLYsEsLARYGKsPYL
P50990 T398 Sugiyama CCT8 C21orf112 CCTQ KIAA0002 RGstDNLMDDIERAVDDGVNtFKVLTRDKRLVPGGGAtEIE
P50990 Y30 Sugiyama CCT8 C21orf112 CCTQ KIAA0002 GFAQMLKEGAKHFsGLEEAVyRNIQACKELAQTTRTAYGPN
P50991 T50 Sugiyama CCT4 CCTD SRB PAQIRFsNISAAKAVADAIRtsLGPKGMDKMIQDGKGDVtI
P50991 T71 Sugiyama CCT4 CCTD SRB sLGPKGMDKMIQDGKGDVtItNDGAtILKQMQVLHPAARML
P51149 T168 Sugiyama RAB7A RAB7 NIPyFEtSAKEAINVEQAFQtIARNALKQETEVELyNEFPE
P52564 S207 EPSD MAP2K6 MEK6 MKK6 PRKMK6 SKK3 INALGQVKMCDFGISGyLVDsVAKtIDAGCKPyMAPERINP
P52564 T211 EPSD MAP2K6 MEK6 MKK6 PRKMK6 SKK3 GQVKMCDFGISGyLVDsVAKtIDAGCKPyMAPERINPELNQ
P52565 Y156 Sugiyama ARHGDIA GDIA1 GVKIDKtDyMVGsYGPRAEEyEFLtPVEEAPKGMLARGsYs
P54577 Y289 Sugiyama YARS1 YARS FPLKSEFVILRDEKWGGNKTytAyVDLEKDFAAEVVHPGDL
P54577 Y292 Sugiyama YARS1 YARS KSEFVILRDEKWGGNKTytAyVDLEKDFAAEVVHPGDLKNS
P54646 T172 EPSD|PSP PRKAA2 AMPK AMPK2 NAKIADFGLSNMMsDGEFLRtsCGsPNyAAPEVISGRLYAG
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P54652 Y42 Sugiyama HSPA2 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P55010 T227 Sugiyama EIF5 ttEEAQRRRMDEISDHAKVLtLsDDLERtIEERVNILFDFV
P55209 Y106 Sugiyama NAP1L1 NRP VKCAQIEAKFyEEVHDLERKyAVLyQPLFDKRFEIINAIYE
P55209 Y110 Sugiyama NAP1L1 NRP QIEAKFyEEVHDLERKyAVLyQPLFDKRFEIINAIYEPTEE
P55795 Y266 Sugiyama HNRNPH2 FTP3 HNRPH2 YGGYNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGssFQst
P56524 S246 EPSD|PSP HDAC4 KIAA0288 NHPVLGMYDAKDDFPLRKTAsEPNLKLRSRLKQKVAERRss
P60174 S106 Sugiyama TPI1 TPI DCGAtWVVLGHsERRHVFGEsDELIGQKVAHALAEGLGVIA
P60174 T217 Sugiyama TPI1 TPI VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60174 T28 Sugiyama TPI1 TPI FVGGNWKMNGRKQsLGELIGtLNAAKVPADtEVVCAPPtAy
P60174 T90 Sugiyama TPI1 TPI VTNGAFtGEIsPGMIKDCGAtWVVLGHsERRHVFGEsDELI
P60228 T439 Sugiyama EIF3E EIF3S6 INT6 AMNIEKKLNQNSRSEAPNWAtQDsGFy______________
P60660 Y86 Sugiyama MYL6 DFEHFLPMLQTVAKNKDQGtyEDyVEGLRVFDKEGNGtVMG
P60660 Y89 Sugiyama MYL6 HFLPMLQTVAKNKDQGtyEDyVEGLRVFDKEGNGtVMGAEI
P60709 S300 Sugiyama ACTB NSIMKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItAL
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 T106 Sugiyama ACTB WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P60709 T201 Sugiyama ACTB AGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVAL
P60709 T202 Sugiyama ACTB GRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVALD
P60709 T249 Sugiyama ACTB tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P60709 T297 Sugiyama ACTB TTFNSIMKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEI
P60709 T303 Sugiyama ACTB MKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPs
P60709 T318 Sugiyama ACTB VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P60709 Y198 Sugiyama ACTB LDLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCy
P60709 Y240 Sugiyama ACTB ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P60709 Y362 Sugiyama ACTB GGsILAsLstFQQMWISKQEyDEsGPsIVHRKCF_______
P60763 T161 Sugiyama RAC3 QGLAMAREIGSVKyLECsALtQRGLKtVFDEAIRAVLCPPP
P61006 T72 SIGNOR|PSP RAB8A MEL RAB8 LDGKRIKLQIWDtAGQERFRtITTAYYRGAMGIMLVYDITN
P61158 S232 Sugiyama ACTR3 ARP3 EVGIPPEQSLETAKAVKERysyVCPDLVKEFNKYDTDGSKW
P61158 Y231 Sugiyama ACTR3 ARP3 REVGIPPEQSLETAKAVKERysyVCPDLVKEFNKYDTDGSK
P61254 T8 Sugiyama RPL26 _____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P61604 T45 Sugiyama HSPE1 TVTKGGIMLPEKSQGKVLQAtVVAVGsGsKGKGGEIQPVsV
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981 S38 Sugiyama YWHAG ERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKNVVGARRS
P61981 T31 Sugiyama YWHAG ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P62191 Y184 Sugiyama PSMC1 MDDTDPLVTVMKVEKAPQETyADIGGLDNQIQEIKESVELP
P62241 Y117 Sugiyama RPS8 OK/SW-cl.83 VKNCIVLIDStPYRQWyEsHyALPLGRKKGAKLtPEEEEIL
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62258 Y152 Sugiyama YWHAE LAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHPIRLG
P62263 S137 Sugiyama RPS14 PRO2640 RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62269 Y95 Sugiyama RPS18 D6S218E RQYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLK
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62280 T54 Sugiyama RPS11 PRYYKNIGLGFKtPKEAIEGtyIDKKCPFTGNVsIRGRILs
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 T251 Sugiyama ACTA2 ACTSA ACTVS GIG46 tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P62736 T320 Sugiyama ACTA2 ACTSA ACTVS GIG46 VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62736 Y242 Sugiyama ACTA2 ACTSA ACTVS GIG46 ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62750 Y144 Sugiyama RPL23A VNtLIRPDGEKKAYVRLAPDyDALDVANKIGII________
P62820 T75 SIGNOR|EPSD|PSP RAB1A RAB1 LDGKTIKLQIWDtAGQERFRtItsSYYRGAHGIIVVYDVTD
P62826 T21 Sugiyama RAN ARA24 OK/SW-cl.81 MAAQGEPQVQFKLVLVGDGGtGKttFVKRHLtGEFEKKyVA
P62826 T66 Sugiyama RAN ARA24 OK/SW-cl.81 EVHPLVFHTNRGPIKFNVWDtAGQEKFGGLRDGYYIQAQCA
P62826 Y146 Sugiyama RAN ARA24 OK/SW-cl.81 IKDRKVKAKsIVFHRKKNLQyyDIsAKSNyNFEKPFLWLAR
P62826 Y147 Sugiyama RAN ARA24 OK/SW-cl.81 KDRKVKAKsIVFHRKKNLQyyDIsAKSNyNFEKPFLWLARK
P62857 T57 Sugiyama RPS28 DtsRsIIRNVKGPVREGDVLtLLEsEREARRLR________
P62899 T26 Sugiyama RPL31 KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62906 Y11 Sugiyama RPL10A NEDD6 __________MSSKVsRDtLyEAVREVLHGNQRKRRKFLET
P62942 T28 Sugiyama FKBP1A FKBP1 FKBP12 IsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRDRNKPFK
P62942 T7 Sugiyama FKBP1A FKBP1 FKBP12 ______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P62979 Y148 Sugiyama RPS27A UBA80 UBCEP1 AGVFMAsHFDRHyCGKCCLtyCFNKPEDK____________
P63000 T161 Sugiyama RAC1 TC25 MIG5 QGLAMAKEIGAVKyLECsALtQRGLKtVFDEAIRAVLCPPP
P63104 S37 Sugiyama YWHAZ ERyDDMAACMKsVtEQGAELsNEERNLLsVAyKNVVGARRs
P63104 T232 Sugiyama YWHAZ KDstLIMQLLRDNLtLWtsDtQGDEAEAGEGGEN_______
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63104 Y149 Sugiyama YWHAZ LAEVAAGDDKKGIVDQsQQAyQEAFEIsKKEMQPTHPIRLG
P63167 T26 Sugiyama DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1 AVIKNADMsEEMQQDsVECAtQALEKYNIEKDIAAHIKKEF
P63173 T14 Sugiyama RPL38 _______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63220 Y53 Sugiyama RPS21 QMNVAEVDKVTGRFNGQFKtyAICGAIRRMGEsDDsILRLA
P63261 S300 Sugiyama ACTG1 ACTG NSIMKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItAL
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 T106 Sugiyama ACTG1 ACTG WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P63261 T201 Sugiyama ACTG1 ACTG AGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVAL
P63261 T202 Sugiyama ACTG1 ACTG GRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVALD
P63261 T249 Sugiyama ACTG1 ACTG tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P63261 T297 Sugiyama ACTG1 ACTG TTFNSIMKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEI
P63261 T303 Sugiyama ACTG1 ACTG MKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPs
P63261 T318 Sugiyama ACTG1 ACTG VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63261 Y198 Sugiyama ACTG1 ACTG LDLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCy
P63261 Y240 Sugiyama ACTG1 ACTG ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63261 Y362 Sugiyama ACTG1 ACTG GGsILAsLstFQQMWISKQEyDEsGPsIVHRKCF_______
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 T250 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P63267 T319 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P63267 Y241 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P67936 T241 Sugiyama TPM4 EEKLAQAKEENVGLHQtLDQtLNELNCI_____________
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 T251 Sugiyama ACTC1 ACTC tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68032 T320 Sugiyama ACTC1 ACTC VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032 Y242 Sugiyama ACTC1 ACTC ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68104 T261 EPSD|PSP EEF1A1 EEF1A EF1A LENG7 PTDKPLRLPLQDVyKIGGIGtVPVGRVEtGVLKPGMVVtFA
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 T251 Sugiyama ACTA1 ACTA tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68133 T320 Sugiyama ACTA1 ACTA VMSGGTTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133 Y242 Sugiyama ACTA1 ACTA ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68363 T334 EPSD|PSP|Sugiyama TUBA1B ACCLLyRGDVVPKDVNAAIAtIKtKRsIQFVDWCPTGFKVG
P68363 T56 Sugiyama TUBA1B MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVID
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P78371 T64 Sugiyama CCT2 99D8.1 CCTB GPKGMDKILLsSGRDAsLMVtNDGAtILKNIGVDNPAAKVL
P78527 T2647 Sugiyama PRKDC HYRC HYRC1 ARWPVAGQIRAtQQQHDFtLtQtADGRssFDWLTGsstDPL
P78527 T2649 Sugiyama PRKDC HYRC HYRC1 WPVAGQIRAtQQQHDFtLtQtADGRssFDWLTGsstDPLVD
P84022 S422 iPTMNet|EPSD SMAD3 MADH3 GPLQWLDKVLTQMGsPsIRCssVs_________________
P84022 S423 iPTMNet|EPSD SMAD3 MADH3 PLQWLDKVLTQMGsPsIRCssVs__________________
P84022 S425 iPTMNet|EPSD SMAD3 MADH3 QWLDKVLTQMGsPsIRCssVs____________________
P84098 T29 Sugiyama RPL19 RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
Q00610 S147 Sugiyama CLTC CLH17 CLTCL2 KIAA0034 VYHWSMEGESQPVKMFDRHssLAGCQIINYRTDAKQKWLLL
Q00613 S363 Sugiyama HSF1 HSTF1 AsVTALtDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNE
Q00839 T582 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 CLGKFIEIAARKKRNFILDQtNVsAAAQRRKMCLFAGFQRK
Q00839 Y260 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 GDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVEEED
Q01094 S337 EPSD|PSP E2F1 RBBP3 TSEEENRAtDsAtIVsPPPssPPssLttDPSQSLLSLEQEP
Q01105 S161 Sugiyama SET FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q01130 S212 Sugiyama SRSF2 SFRS2 PPPVsKRESKSRSRsKsPPKsPEEEGAVss___________
Q01518 T165 Sugiyama CAP1 CAP AMAPKPGPYVKEMNDAAMFytNRVLKEYKDVDKKHVDWVKA
Q01518 Y164 Sugiyama CAP1 CAP VAMAPKPGPYVKEMNDAAMFytNRVLKEYKDVDKKHVDWVK
Q02543 Y97 Sugiyama RPL18A NFGIWLRYDsRSGtHNMYREyRDLttAGAVtQCyRDMGARH
Q02818 S193 Sugiyama NUCB1 NUC HEEFKRyEMLKEHERRRyLEsLGEEQRKEAERKLEEQQRRH
Q06830 T143 Sugiyama PRDX1 PAGA PAGB TDPX2 EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q06830 Y116 Sugiyama PRDX1 PAGA PAGB TDPX2 GLGPMNIPLVSDPKRtIAQDyGVLKADEGIsFRGLFIIDDK
Q12906 T300 Sugiyama ILF3 DRBF MPHOSPH4 NF90 ASGIVMPDGSGIYDPCEKEAtDAIGHLDRQQREDItQsAQH
Q13136 T572 Sugiyama PPFIA1 LIP1 LRRPQKGRLAALRDEPSKVQtLNEQDWERAQQASVLANVAQ
Q13200 T351 Sugiyama PSMD2 TRAP2 LALARELDIMEPKVPDDIyKtHLENNRFGGsGsQVDSARMN
Q13200 Y349 Sugiyama PSMD2 TRAP2 NFLALARELDIMEPKVPDDIyKtHLENNRFGGsGsQVDSAR
Q13263 Y242 Sugiyama TRIM28 KAP1 RNF96 TIF1B ESCDTLTCRDCQLNAHKDHQyQFLEDAVRNQRKLLAsLVKR
Q13283 S232 Sugiyama G3BP1 G3BP EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13310 T191 Sugiyama PABPC4 APP1 PABP4 GRFKSRKEREAELGAKAKEFtNVyIKNFGEEVDDEsLKELF
Q13509 S75 Sugiyama TUBB3 TUBB4 SSHKYVPRAILVDLEPGtMDsVRSGAFGHLFRPDNFIFGQS
Q13765 Y120 Sugiyama NACA HSD48 KNILFVITKPDVYKSPAsDtyIVFGEAKIEDLsQQAQLAAA
Q13885 S75 Sugiyama TUBB2A TUBB2 AGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q14152 T1378 Sugiyama EIF3A EIF3S10 KIAA0139 AEKDREsLRRTKNEtDEDGWttVRR________________
Q14152 T1379 Sugiyama EIF3A EIF3S10 KIAA0139 EKDREsLRRTKNEtDEDGWttVRR_________________
Q14247 T68 Sugiyama CTTN EMS1 GHQEHINIHKLRENVFQEHQtLKEKELETGPKASHGyGGKF
Q14257 Y311 Sugiyama RCN2 ERC55 NPDLFLtsEAtDyGRQLHDDyFyHDEL______________
Q14257 Y313 Sugiyama RCN2 ERC55 DLFLtsEAtDyGRQLHDDyFyHDEL________________
Q14568 S165 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGTK
Q14568 S52 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14568 S53 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14568 Y160 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 SAYLVAEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGERM
Q14568 Y283 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 sDEEEEKKDGDKKKKKTKEKyIDQEELNKTKPIWTRNPDDI
Q14697 T229 Sugiyama GANAB G2AN KIAA0088 DKPEETQGKAEKDEPGAWEEtFKTHSDSKPYGPMSVGLDFS
Q14C86 S1012 EPSD|PSP GAPVD1 GAPEX5 KIAA1521 RAP6 PFRKKEKQEKDKDDLGPDRFstLTDDPsPRLSAQAQVAEDI
Q14C86 T1013 EPSD|PSP GAPVD1 GAPEX5 KIAA1521 RAP6 FRKKEKQEKDKDDLGPDRFstLTDDPsPRLSAQAQVAEDIL
Q15056 S14 Sugiyama EIF4H KIAA0038 WBSCR1 WSCR1 _______MADFDtyDDRAyssFGGGRGsRGsAGGHGsRSQK
Q15056 T100 Sugiyama EIF4H KIAA0038 WBSCR1 WSCR1 KFKGFCyVEFDEVDsLKEALtyDGALLGDRsLRVDIAEGRK
Q15084 T166 Sugiyama PDIA6 ERP5 P5 TXNDC7 YSSGKQGRSDsSSKKDVIELtDDsFDKNVLDSEDVWMVEFY
Q15181 Y169 Sugiyama PPA1 IOPPP PP EGETDWKVIAINVDDPDAANyNDINDVKRLKPGYLEATVDW
Q15293 S69 Sugiyama RCN1 RCN PPEDNQsFQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVD
Q15293 Y278 Sugiyama RCN1 RCN LNKDGKLDKDEIRHWILPQDyDHAQAEARHLVyESDKNKDE
Q15750 S452 SIGNOR|EPSD|PSP TAB1 MAP3K7IP1 PTLTNQsPTLTLQSTNTHTQssSSssDGGLFRSRPAHSLPP
Q15750 S453 SIGNOR|EPSD|PSP TAB1 MAP3K7IP1 TLTNQsPTLTLQSTNTHTQssSSssDGGLFRSRPAHSLPPG
Q15750 S456 SIGNOR|EPSD|PSP TAB1 MAP3K7IP1 NQsPTLTLQSTNTHTQssSSssDGGLFRSRPAHSLPPGEDG
Q15750 S457 SIGNOR|EPSD|PSP TAB1 MAP3K7IP1 QsPTLTLQSTNTHTQssSSssDGGLFRSRPAHSLPPGEDGR
Q15819 T142 Sugiyama UBE2V2 MMS2 UEV2 LRRLMMSKENMKLPQPPEGQtyNN_________________
Q16658 T239 Sugiyama FSCN1 FAN1 HSN SNL GKVAFRDCEGRyLAPsGPsGtLKAGKATKVGKDELFALEQs
Q16719 S443 Sugiyama KYNU VVCDKRNPNGIRVAPVPLyNsFHDVyKFTNLLtsILDsAET
Q16719 Y448 Sugiyama KYNU RNPNGIRVAPVPLyNsFHDVyKFTNLLtsILDsAETKN___
Q16775 T291 Sugiyama HAGH GLO2 HAGH1 PFMRVREKTVQQHAGETDPVttMRAVRREKDQFKMPRD___
Q27J81 S1204 Sugiyama INF2 C14orf151 C14orf173 ALDtsLDKsFsEDAVtDssGsGtLPRARGRASKGTGKRRKK
Q27J81 T1206 Sugiyama INF2 C14orf151 C14orf173 DtsLDKsFsEDAVtDssGsGtLPRARGRASKGTGKRRKKRP
Q2VIR3 T21 Sugiyama EIF2S3B MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q3ZCM7 S75 Sugiyama TUBB8 SGGRYVPRAVLVDLEPGtMDsVRSGPFGQVFRPDNFIFGQC
Q4VXU2 Y291 Sugiyama PABPC1L C20orf119 ERQNELKRRFEQMKQDRLRRyQGVNLyVKNLDDSIDDDKLR
Q4VXU2 Y297 Sugiyama PABPC1L C20orf119 KRRFEQMKQDRLRRyQGVNLyVKNLDDSIDDDKLRKEFSPY
Q562R1 T250 Sugiyama ACTBL2 RAAAssSPERsyELPDGQVItIGNERFRCPEAIFQPSFLGI
Q562R1 Y241 Sugiyama ACTBL2 ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q58FF6 Y167 Sugiyama HSP90AB4P GEPIDRDTKVILHLKEDQtEyLEERWVKEVVKKHPQFIGCL
Q58FF7 Y171 Sugiyama HSP90AB3P HSP90BC GEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIGyP
Q58FF8 Y198 Sugiyama HSP90AB2P HSP90BB DEEDDsGKDKKKKTKKIKEKyIDQEELNKTKPIWTRNTEDI
Q58FF8 Y260 Sugiyama HSP90AB2P HSP90BB VRYFSVEEYVSRMKEIQKsIyyItGEsKEQVANSAFVEQVW
Q58FF8 Y261 Sugiyama HSP90AB2P HSP90BB RYFSVEEYVSRMKEIQKsIyyItGEsKEQVANSAFVEQVWK
Q58FG0 Y177 Sugiyama HSP90AA5P HSP90AE GQLEELKDSRRVMKANQKHIyyItGETKDQVANSAFVECLQ
Q58FG0 Y178 Sugiyama HSP90AA5P HSP90AE QLEELKDSRRVMKANQKHIyyItGETKDQVANSAFVECLQK
Q5SQI0 S237 SIGNOR|EPSD|PSP ATAT1 C6orf134 MEC17 Nbla00487 AAPARKLPPKRAEGDIKPYSsSDREFLKVAVEPPWPLNRAP
Q6P589 S3 SIGNOR|PSP TNFAIP8L2 __________________MEsFSSKSLALQAEKKLLSKMAG
Q6PEY2 T334 Sugiyama TUBA3E ACCMLYRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
Q6PEY2 T56 Sugiyama TUBA3E MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVVD
Q6S8J3 T949 Sugiyama POTEE A26C1A POTE2 tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q6S8J3 Y1062 Sugiyama POTEE A26C1A POTE2 GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCF_______
Q6S8J3 Y940 Sugiyama POTEE A26C1A POTE2 ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q6UN15 S492 Sugiyama FIP1L1 FIP1 RHE DRDRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAE
Q6UN15 T494 Sugiyama FIP1L1 FIP1 RHE DRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAERG
Q71U36 T334 Sugiyama TUBA1A TUBA3 ACCLLyRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
Q71U36 T56 Sugiyama TUBA1A TUBA3 MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVID
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q7KZF4 Y476 Sugiyama SND1 TDRD11 SKGLATVIRYRQDDDQRssHyDELLAAEARAIKNGKGLHSK
Q7Z3J3 T1210 Sugiyama RGPD4 RGP4 KLIQRAEEMKSGLKDFKTFLtNDQTKVTEEENKGsGtGAAG
Q86WV6 S355 SIGNOR STING1 ERIS MITA STING TMEM173 QEEKEEVTVGSLKTSAVPSTsTMsQEPELLIsGMEKPLPLR
Q8IVT5 S406 SIGNOR|EPSD|PSP KSR1 KSR KEAPACRISFLPLTRLRRtEsVPsDINNPVDRAAEPHFGtL
Q8IZ21 S118 Sugiyama PHACTR4 PRO2963 PSDAMLKNGHTTPIGNARsssPVQVEEEPVRLAsLRKAIPE
Q8N684 T203 Sugiyama CPSF7 GGIPPRAHsRDssDsADGRAtPsENLVPSSARVDKPPSVLP
Q8NBJ7 T260 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 SPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMGNtPD
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8WUI4 S155 SIGNOR|EPSD|PSP HDAC7 HDAC7A PPVPSLPSDPPEHFPLRKtVsEPNLKLRYKPKKSLERRKNP
Q8WXX5 S215 Sugiyama DNAJC9 EEAKEAEMSRKELGLDEGVDsLKAAIQSRQKDRQKEMDNFL
Q92598 T365 Sugiyama HSPH1 HSP105 HSP110 KIAA0201 TRIPAVKERIAKFFGKDISTtLNADEAVARGCALQCAILsP
Q92598 Y641 Sugiyama HSPH1 HSP105 HSP110 KIAA0201 MIMQDKLEKERNDAKNAVEEyVyEFRDKLCGPYEKFICEQD
Q92598 Y643 Sugiyama HSPH1 HSP105 HSP110 KIAA0201 MQDKLEKERNDAKNAVEEyVyEFRDKLCGPYEKFICEQDHQ
Q96CT7 T103 Sugiyama CCDC124 GGKAPRVATSSKVTRAQIEDtLRRDHQLREAPDTAEKAKsH
Q96HE7 T293 Sugiyama ERO1A ERO1L UNQ434/PRO865 LEKKWGHNITEFQQRFDGILtEGEGPRRLKNLYFLYLIELR
Q96S44 T8 Sugiyama TP53RK C20orf64 PRPK _____________MAAARAttPADGEEPAPEAEALAAARER
Q99426 T120 Sugiyama TBCB CG22 CKAP1 DVSRVEKytIsQEAyDQRQDtVRSFLKRsKLGRyNEEERAQ
Q99497 T154 Sugiyama PARK7 MNGGHytysENRVEKDGLILtSRGPGTSFEFALAIVEALNG
Q99613 T880 Sugiyama EIF3C EIF3S8 AEKLGsLVENNERVFDHKQGtyGGyFRDQKDGYRKNEGYMR
Q99613 Y884 Sugiyama EIF3C EIF3S8 GsLVENNERVFDHKQGtyGGyFRDQKDGYRKNEGYMRRGGY
Q99666 T1209 Sugiyama RGPD5 RANBP2L1 RGP5 RGP7 RGPD7; RGPD6 RANBP2L2 RGP6 KLIQRAEEMKSGLKDFKTFLtNDQTKVTEEENKGsGtGAAG
Q99733 Y95 Sugiyama NAP1L4 NAP2 VRCAHIEAKFyEEVHDLERKyAALyQPLFDKRREFItGDVE
Q99733 Y99 Sugiyama NAP1L4 NAP2 HIEAKFyEEVHDLERKyAALyQPLFDKRREFItGDVEPtDA
Q99832 T351 Sugiyama CCT7 CCTH NIP7-1 QtSVNALSADVLGRCQVFEEtQIGGERyNFFtGCPKAKTCt
Q99959 S82 PSP PKP2 QtLARKGRssVGNGNLHRtssVPEyVyNLHLVENDFVGGRs
Q9BQE3 T334 Sugiyama TUBA1C TUBA6 ACCLLyRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
Q9BQE3 T56 Sugiyama TUBA1C TUBA6 MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVID
Q9BQE3 Y432 Sugiyama TUBA1C TUBA6 GMEEGEFSEAREDMAALEKDyEEVGADsADGEDEGEEy___
Q9BS26 T155 Sugiyama ERP44 KIAA0573 TXNDC4 UNQ532/PRO1075 yIRQQKSDPIQEIRDLAEIttLDRSKRNIIGYFEQKDSDNy
Q9BV20 T363 Sugiyama MRI1 MRDI UNQ6390/PRO21135 VFAPEELRtALTTTISSRDGtLDGPQM______________
Q9BVA1 S75 Sugiyama TUBB2B tGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q9BYX7 T249 Sugiyama POTEKP ACTBL3 FKSG30 MAASSSSVEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q9BYX7 Y240 Sugiyama POTEKP ACTBL3 FKSG30 ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9BYX7 Y362 Sugiyama POTEKP ACTBL3 FKSG30 GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCF_______
Q9C0C2 S672 Sugiyama TNKS1BP1 KIAA1741 TAB182 TLARAETtQARtEAQDLCRAsPEPPGPEsSSRWLDDLLAsP
Q9C0C2 T1323 Sugiyama TNKS1BP1 KIAA1741 TAB182 ELGVGQMDWGNNLGLRDLEVtCDPDsGGsQGLRGCGVGQMD
Q9H2G2 T1233 Sugiyama SLK KIAA0204 STK2 LNPStQsRISKFyPIPsLHstGs__________________
Q9H2X6 Y361 PSP HIPK2 RVKVIDFGSAsHVSKAVCstyLQsRYyRAPEIILGLPFCEA
Q9H444 T101 Sugiyama CHMP4B C20orf178 SHAX1 QIDGtLstIEFQREALENANtNtEVLKNMGYAAKAMKAAHD
Q9H4A3 S1261 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 GIPTSSLTQVVHSAGRRFIVsPVPEsRLRESKVFPSEITDT
Q9H7N4 S498 Sugiyama SCAF1 SFRS19 SRA1 GGLDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKK
Q9H7N4 S500 Sugiyama SCAF1 SFRS19 SRA1 LDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKKSR
Q9NRX4 T119 Sugiyama PHPT1 PHP14 CGI-202 HSPC141 PAQHAISTEKIKAKyPDyEVtWANDGy______________
Q9NVS9 Y256 Sugiyama PNPO LPtGDsPLGPMTHRGEEDWLyERLAP_______________
Q9NWB6 S77 Sugiyama ARGLU1 RsRstNTAVSRRERDRERAssPPDRIDIFGRTVSKRSSLDE
Q9UBR2 Y76 Sugiyama CTSZ YLSPADLPKSWDWRNVDGVNyAsItRNQHIPQYCGSCWAHA
Q9UKS6 T209 Sugiyama PACSIN3 QERVERCAKEAEKTKAQyEQtLAELHRYTPRYMEDMEQAFE
Q9UNX3 T8 Sugiyama RPL26L1 RPL26P1 _____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Q9UQ35 S1102 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 EsPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFs
Q9UQ35 S1103 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35 S1648 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 APRALPRRSRSGSSSKGRGPsPEGssstEssPEHPPKSRTA
Q9UQ35 S2132 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9UQ35 S2692 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9UQ80 T386 Sugiyama PA2G4 EBP1 tQKKKKKKAsKtAENAtsGEtLEENEAGD____________
Q9UQL6 S259 EPSD|PSP HDAC5 KIAA0600 KLPLPGPYDSRDDFPLRKTAsEPNLKVRSRLKQKVAERRss
Q9Y281 Y85 Sugiyama CFL2 EDPYtsFVKLLPLNDCRyALyDAtyEtKESKKEDLVFIFWA
Q9Y281 Y89 Sugiyama CFL2 tsFVKLLPLNDCRyALyDAtyEtKESKKEDLVFIFWAPESA
Q9Y295 T62 Sugiyama DRG1 NEDD3 LITPKGGGGGGPGEGFDVAKtGDARIGFVGFPSVGKSTLLS
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y3D8 Y31 Sugiyama AK6 CINAP AD-004 CGI-137 TPGVGKTTLGKELASKSGLKyINVGDLAREEQLYDGYDEEY
Q9Y3F4 T117 Sugiyama STRAP MAWD UNRIP LAHKHIVKtVDFtQDSNyLLtGGQDKLLRIYDLNKPEAEPK
Q9Y3U8 Y53 Sugiyama RPL36 LTKHTKFVRDMIREVCGFAPyERRAMELLKVSKDKRALKFI
Q9Y5K6 T465 Sugiyama CD2AP LKLDsEQLPLRPKsVDFDsLtVRtsKEtDVVNFDDIASSEN
Q9Y5S9 S56 Sugiyama RBM8A RBM8 HSPC114 MDS014 KGRGFGsEEGsRARMREDyDsVEQDGDEPGPQRSVEGWILF
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Axon guidance R-HSA-422475 6.830683e-09 8.166 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 8.390166e-09 8.076 0 0
Nervous system development R-HSA-9675108 2.049985e-08 7.688 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.923712e-07 6.716 0 0
Post NMDA receptor activation events R-HSA-438064 2.615841e-07 6.582 0 0
Signal Transduction R-HSA-162582 5.111000e-07 6.291 1 0
Signaling by VEGF R-HSA-194138 6.755678e-07 6.170 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 6.786235e-07 6.168 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.153534e-06 5.938 0 0
Cell Cycle R-HSA-1640170 1.346661e-06 5.871 0 0
Cell Cycle, Mitotic R-HSA-69278 1.738785e-06 5.760 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.329961e-06 5.633 0 0
L1CAM interactions R-HSA-373760 3.693098e-06 5.433 0 0
Signaling by SCF-KIT R-HSA-1433557 5.504279e-06 5.259 0 0
M Phase R-HSA-68886 7.057353e-06 5.151 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 7.508367e-06 5.124 0 0
Recycling pathway of L1 R-HSA-437239 1.104201e-05 4.957 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.240345e-05 4.906 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.234530e-05 4.908 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.535551e-05 4.814 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.535551e-05 4.814 0 0
Aggrephagy R-HSA-9646399 1.635999e-05 4.786 0 0
Autophagy R-HSA-9612973 1.615023e-05 4.792 0 0
Kinesins R-HSA-983189 1.524442e-05 4.817 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.823000e-05 4.739 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.308356e-05 4.637 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.308356e-05 4.637 0 0
Membrane Trafficking R-HSA-199991 2.311481e-05 4.636 0 0
Signaling by Hippo R-HSA-2028269 2.559179e-05 4.592 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.627314e-05 4.580 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.804823e-05 4.552 0 0
Selective autophagy R-HSA-9663891 2.785101e-05 4.555 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.804823e-05 4.552 0 0
Glycolysis R-HSA-70171 3.073144e-05 4.512 0 0
Nuclear import of Rev protein R-HSA-180746 3.388986e-05 4.470 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 4.072991e-05 4.390 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.224895e-05 4.374 0 0
Macroautophagy R-HSA-1632852 4.723160e-05 4.326 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 5.288216e-05 4.277 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 5.795214e-05 4.237 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 6.864025e-05 4.163 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 8.093996e-05 4.092 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 7.832982e-05 4.106 0 0
Cellular response to heat stress R-HSA-3371556 7.820689e-05 4.107 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 8.093996e-05 4.092 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 9.503968e-05 4.022 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 9.503968e-05 4.022 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 9.503968e-05 4.022 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.111431e-04 3.954 0 0
Mitotic Anaphase R-HSA-68882 1.328911e-04 3.877 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.409016e-04 3.851 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.733882e-04 3.761 0 0
EPH-Ephrin signaling R-HSA-2682334 1.794369e-04 3.746 0 0
Glucose metabolism R-HSA-70326 1.867040e-04 3.729 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.022725e-04 3.694 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 2.210281e-04 3.656 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.288981e-04 3.640 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 2.299928e-04 3.638 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.301423e-04 3.638 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.554505e-04 3.593 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.633274e-04 3.580 0 0
RET signaling R-HSA-8853659 2.785109e-04 3.555 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.754761e-04 3.560 0 0
FLT3 signaling in disease R-HSA-9682385 2.785109e-04 3.555 0 0
Transport of connexons to the plasma membrane R-HSA-190872 2.796207e-04 3.553 0 0
Metabolism of non-coding RNA R-HSA-194441 2.916243e-04 3.535 0 0
snRNP Assembly R-HSA-191859 2.916243e-04 3.535 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 3.269722e-04 3.485 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 3.662081e-04 3.436 0 0
Viral Messenger RNA Synthesis R-HSA-168325 3.662681e-04 3.436 0 0
G2/M Transition R-HSA-69275 3.988580e-04 3.399 0 0
ISG15 antiviral mechanism R-HSA-1169408 4.000212e-04 3.398 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 4.091781e-04 3.388 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 4.329663e-04 3.364 0 0
Mitotic G2-G2/M phases R-HSA-453274 4.478950e-04 3.349 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 5.274787e-04 3.278 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 5.637188e-04 3.249 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 5.779623e-04 3.238 0 0
SOS-mediated signalling R-HSA-112412 6.222475e-04 3.206 0 0
Signaling by FGFR1 in disease R-HSA-5655302 6.516481e-04 3.186 0 0
Signaling by RAF1 mutants R-HSA-9656223 6.516481e-04 3.186 0 0
Cytokine Signaling in Immune system R-HSA-1280215 6.726775e-04 3.172 1 0
Regulation of KIT signaling R-HSA-1433559 6.807408e-04 3.167 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 7.017728e-04 3.154 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 7.509894e-04 3.124 0 0
Signaling by ALK in cancer R-HSA-9700206 7.509894e-04 3.124 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 8.152081e-04 3.089 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 8.650856e-04 3.063 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 8.720760e-04 3.059 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 8.844478e-04 3.053 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 8.844478e-04 3.053 0 0
Vesicle-mediated transport R-HSA-5653656 9.149833e-04 3.039 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.104711e-03 2.957 0 0
Signaling by RAS mutants R-HSA-6802949 1.205719e-03 2.919 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.205719e-03 2.919 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.205719e-03 2.919 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.205719e-03 2.919 0 0
Apoptotic execution phase R-HSA-75153 1.205719e-03 2.919 0 0
Oncogene Induced Senescence R-HSA-2559585 1.244305e-03 2.905 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.351915e-03 2.869 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.325088e-03 2.878 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.394948e-03 2.855 0 0
Calmodulin induced events R-HSA-111933 1.421020e-03 2.847 0 0
CaM pathway R-HSA-111997 1.421020e-03 2.847 0 0
Mitotic Prometaphase R-HSA-68877 1.480130e-03 2.830 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.629784e-03 2.788 0 0
Regulation of CDH11 function R-HSA-9762292 1.626305e-03 2.789 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.616730e-03 2.791 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.528186e-03 2.816 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.527332e-03 2.816 0 0
tRNA processing in the nucleus R-HSA-6784531 1.611295e-03 2.793 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.662400e-03 2.779 0 0
Gap junction trafficking and regulation R-HSA-157858 1.686445e-03 2.773 0 0
Immune System R-HSA-168256 1.744957e-03 2.758 1 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.781368e-03 2.749 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.839114e-03 2.735 0 0
Separation of Sister Chromatids R-HSA-2467813 1.883240e-03 2.725 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.989517e-03 2.701 0 0
Mitotic Prophase R-HSA-68875 2.125243e-03 2.673 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.331904e-03 2.632 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.387273e-03 2.622 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 2.380707e-03 2.623 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.263866e-03 2.645 0 0
PKR-mediated signaling R-HSA-9833482 2.227835e-03 2.652 0 0
IRS activation R-HSA-74713 2.516990e-03 2.599 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 2.563433e-03 2.591 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.617198e-03 2.582 0 0
MAP2K and MAPK activation R-HSA-5674135 2.928954e-03 2.533 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.928954e-03 2.533 0 0
COPI-mediated anterograde transport R-HSA-6807878 2.947577e-03 2.531 0 0
Cellular responses to stimuli R-HSA-8953897 2.955316e-03 2.529 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 3.122922e-03 2.505 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 3.654196e-03 2.437 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.416079e-03 2.466 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.285260e-03 2.483 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 3.319578e-03 2.479 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 3.351410e-03 2.475 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 3.654196e-03 2.437 0 0
Signaling by EGFR R-HSA-177929 3.399295e-03 2.469 0 0
Ca-dependent events R-HSA-111996 3.268369e-03 2.486 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 3.654196e-03 2.437 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.869271e-03 2.412 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.926064e-03 2.406 0 0
MAPK family signaling cascades R-HSA-5683057 3.995360e-03 2.398 0 0
HCMV Early Events R-HSA-9609690 4.018651e-03 2.396 0 0
FGFR1 mutant receptor activation R-HSA-1839124 4.023872e-03 2.395 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.036398e-03 2.394 0 0
Gap junction trafficking R-HSA-190828 4.036398e-03 2.394 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 4.406089e-03 2.356 0 0
Cellular Senescence R-HSA-2559583 4.424111e-03 2.354 0 0
DAG and IP3 signaling R-HSA-1489509 4.468176e-03 2.350 0 0
Signaling by FGFR in disease R-HSA-1226099 4.528233e-03 2.344 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 4.567937e-03 2.340 0 0
Signaling by KIT in disease R-HSA-9669938 4.567937e-03 2.340 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.801507e-03 2.319 0 0
Signaling by NTRKs R-HSA-166520 5.013235e-03 2.300 0 0
Gap junction assembly R-HSA-190861 5.103987e-03 2.292 0 0
HDL assembly R-HSA-8963896 5.159857e-03 2.287 0 0
Signaling by Interleukins R-HSA-449147 5.435607e-03 2.265 1 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 6.220687e-03 2.206 0 0
p38MAPK events R-HSA-171007 6.220687e-03 2.206 0 0
Semaphorin interactions R-HSA-373755 6.228309e-03 2.206 0 0
GPVI-mediated activation cascade R-HSA-114604 6.382809e-03 2.195 0 0
Insulin receptor signalling cascade R-HSA-74751 6.745992e-03 2.171 0 0
MHC class II antigen presentation R-HSA-2132295 6.783014e-03 2.169 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 6.937377e-03 2.159 0 0
Host Interactions of HIV factors R-HSA-162909 7.160629e-03 2.145 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 7.417166e-03 2.130 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 7.417166e-03 2.130 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 7.417166e-03 2.130 0 0
Myogenesis R-HSA-525793 7.888303e-03 2.103 0 0
Cellular responses to stress R-HSA-2262752 7.937374e-03 2.100 0 0
Activation of RAS in B cells R-HSA-1169092 8.742702e-03 2.058 0 0
Interaction between L1 and Ankyrins R-HSA-445095 8.926154e-03 2.049 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.126460e-03 2.090 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 9.147582e-03 2.039 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 8.716165e-03 2.060 0 0
Clathrin-mediated endocytosis R-HSA-8856828 9.393137e-03 2.027 0 0
HCMV Infection R-HSA-9609646 8.141672e-03 2.089 0 0
Signaling by ALK R-HSA-201556 8.716165e-03 2.060 0 0
Adaptive Immune System R-HSA-1280218 8.729384e-03 2.059 1 0
Signaling by NTRK1 (TRKA) R-HSA-187037 9.303374e-03 2.031 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 8.954840e-03 2.048 1 1
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.024355e-02 1.990 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.024355e-02 1.990 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.024355e-02 1.990 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.030521e-02 1.987 0 0
Regulation of TP53 Expression R-HSA-6804754 1.030521e-02 1.987 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.030521e-02 1.987 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.030521e-02 1.987 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.030521e-02 1.987 0 0
Signaling by RAS GAP mutants R-HSA-9753510 1.030521e-02 1.987 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.030521e-02 1.987 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.030521e-02 1.987 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.030521e-02 1.987 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.030521e-02 1.987 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.030521e-02 1.987 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.030521e-02 1.987 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.030521e-02 1.987 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.057633e-02 1.976 0 0
FLT3 Signaling R-HSA-9607240 1.057633e-02 1.976 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.070205e-02 1.971 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.104183e-02 1.957 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.127715e-02 1.948 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.131662e-02 1.946 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.188555e-02 1.925 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.188555e-02 1.925 0 0
Signal attenuation R-HSA-74749 1.365782e-02 1.865 0 0
Regulation of CDH1 Function R-HSA-9764561 1.276658e-02 1.894 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.365782e-02 1.865 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 1.371269e-02 1.863 1 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 1.371269e-02 1.863 1 0
IRS-mediated signalling R-HSA-112399 1.276658e-02 1.894 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.338795e-02 1.873 0 0
Signaling by Leptin R-HSA-2586552 1.365782e-02 1.865 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.181945e-02 1.927 0 0
Downstream signal transduction R-HSA-186763 1.401813e-02 1.853 0 0
Signaling by FGFR1 amplification mutants R-HSA-1839120 1.570848e-02 1.804 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 1.588784e-02 1.799 1 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 1.588784e-02 1.799 1 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.606772e-02 1.794 0 0
Gene Silencing by RNA R-HSA-211000 1.655044e-02 1.781 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 1.710407e-02 1.767 0 0
PLC beta mediated events R-HSA-112043 1.710407e-02 1.767 0 0
Integrin signaling R-HSA-354192 1.717452e-02 1.765 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.717452e-02 1.765 0 0
HIV Life Cycle R-HSA-162587 1.746347e-02 1.758 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.778916e-02 1.750 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.778916e-02 1.750 0 0
Signalling to RAS R-HSA-167044 1.778916e-02 1.750 0 0
NCAM signaling for neurite out-growth R-HSA-375165 1.833312e-02 1.737 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 1.928942e-02 1.715 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.962289e-02 1.707 0 0
Signaling by PTK6 R-HSA-8848021 1.962289e-02 1.707 0 0
Regulation of TP53 Activity R-HSA-5633007 1.972671e-02 1.705 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 2.009735e-02 1.697 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.017003e-02 1.695 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 2.524500e-02 1.598 0 0
AURKA Activation by TPX2 R-HSA-8854518 2.386999e-02 1.622 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.482232e-02 1.605 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.535784e-02 1.596 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.046070e-02 1.689 0 0
mTORC1-mediated signalling R-HSA-166208 2.258168e-02 1.646 0 0
Co-stimulation by CD28 R-HSA-389356 2.084143e-02 1.681 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.206931e-02 1.656 0 0
IGF1R signaling cascade R-HSA-2428924 2.097475e-02 1.678 0 0
Cell Cycle Checkpoints R-HSA-69620 2.080766e-02 1.682 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 2.239002e-02 1.650 0 0
Signalling to ERKs R-HSA-187687 2.273733e-02 1.643 0 0
Ion transport by P-type ATPases R-HSA-936837 2.097475e-02 1.678 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.336768e-02 1.631 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.456659e-02 1.610 1 0
Developmental Biology R-HSA-1266738 2.483545e-02 1.605 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.456659e-02 1.610 1 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.456659e-02 1.610 1 0
Degradation of CDH1 R-HSA-9766229 2.247590e-02 1.648 0 0
Interferon Signaling R-HSA-913531 2.160338e-02 1.665 0 0
Transmission across Chemical Synapses R-HSA-112315 2.286473e-02 1.641 0 0
Hemostasis R-HSA-109582 2.333875e-02 1.632 0 0
Inositol phosphate metabolism R-HSA-1483249 2.124296e-02 1.673 0 0
G-protein mediated events R-HSA-112040 2.541590e-02 1.595 0 0
HSF1-dependent transactivation R-HSA-3371571 2.599887e-02 1.585 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.614247e-02 1.583 1 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.702892e-02 1.568 0 0
CD28 dependent Vav1 pathway R-HSA-389359 2.737529e-02 1.563 0 0
HIV Infection R-HSA-162906 2.804586e-02 1.552 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.808967e-02 1.551 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 2.808967e-02 1.551 0 0
Plasma lipoprotein assembly R-HSA-8963898 2.808967e-02 1.551 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.829001e-02 1.548 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.930954e-02 1.533 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.930954e-02 1.533 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.930954e-02 1.533 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 3.111756e-02 1.507 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.111756e-02 1.507 0 0
Chaperonin-mediated protein folding R-HSA-390466 3.141164e-02 1.503 0 0
Interleukin-12 family signaling R-HSA-447115 3.141164e-02 1.503 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 3.228184e-02 1.491 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 3.410248e-02 1.467 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.421743e-02 1.466 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.433011e-02 1.464 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 3.436923e-02 1.464 0 0
Diseases of Immune System R-HSA-5260271 3.436923e-02 1.464 0 0
mRNA Splicing - Major Pathway R-HSA-72163 3.444988e-02 1.463 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 3.705416e-02 1.431 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 3.705416e-02 1.431 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 3.705416e-02 1.431 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 3.735550e-02 1.428 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 4.613773e-02 1.336 0 0
Erythropoietin activates RAS R-HSA-9027284 3.619528e-02 1.441 0 0
Phosphorylation of the APC/C R-HSA-176412 4.108739e-02 1.386 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 4.629448e-02 1.334 0 0
Signaling by Erythropoietin R-HSA-9006335 4.508303e-02 1.346 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 4.508303e-02 1.346 0 0
Late endosomal microautophagy R-HSA-9615710 4.508303e-02 1.346 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 4.368152e-02 1.360 0 0
Signaling by FGFR1 R-HSA-5654736 3.635629e-02 1.439 0 0
CREB phosphorylation R-HSA-199920 4.613773e-02 1.336 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 4.108739e-02 1.386 0 0
DCC mediated attractive signaling R-HSA-418885 3.619528e-02 1.441 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 4.629448e-02 1.334 0 0
Signaling by Insulin receptor R-HSA-74752 4.223495e-02 1.374 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 3.735550e-02 1.428 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 4.613773e-02 1.336 0 0
MTOR signalling R-HSA-165159 4.283792e-02 1.368 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 4.629448e-02 1.334 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 4.131254e-02 1.384 0 0
DARPP-32 events R-HSA-180024 4.508303e-02 1.346 0 0
Nef and signal transduction R-HSA-164944 4.613773e-02 1.336 0 0
Protein folding R-HSA-391251 4.223495e-02 1.374 0 0
Pyroptosis R-HSA-5620971 4.131254e-02 1.384 0 0
Leishmania infection R-HSA-9658195 4.022543e-02 1.395 0 0
Parasitic Infection Pathways R-HSA-9824443 4.022543e-02 1.395 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 4.108860e-02 1.386 1 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 4.629448e-02 1.334 0 0
HCMV Late Events R-HSA-9610379 3.670731e-02 1.435 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 4.288967e-02 1.368 1 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 4.613773e-02 1.336 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 3.619528e-02 1.441 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 3.619528e-02 1.441 0 0
Influenza Infection R-HSA-168255 4.078508e-02 1.389 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.772826e-02 1.423 0 0
Interleukin-12 signaling R-HSA-9020591 4.247507e-02 1.372 0 0
SARS-CoV-2 Infection R-HSA-9694516 4.406285e-02 1.356 1 0
Signaling by ERBB2 R-HSA-1227986 4.631394e-02 1.334 0 0
mRNA Splicing R-HSA-72172 4.852879e-02 1.314 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.903942e-02 1.309 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.903942e-02 1.309 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.903942e-02 1.309 0 0
DAP12 signaling R-HSA-2424491 4.903942e-02 1.309 0 0
Netrin-1 signaling R-HSA-373752 4.912160e-02 1.309 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 4.912160e-02 1.309 0 0
Sensory processing of sound R-HSA-9659379 4.948962e-02 1.305 0 0
Programmed Cell Death R-HSA-5357801 4.998155e-02 1.301 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 5.062184e-02 1.296 1 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 5.181049e-02 1.286 0 0
Signaling by MET R-HSA-6806834 5.198136e-02 1.284 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 5.245632e-02 1.280 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 5.245632e-02 1.280 0 0
SARS-CoV-2-host interactions R-HSA-9705683 5.306341e-02 1.275 1 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 5.479188e-02 1.261 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 5.479188e-02 1.261 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 5.559081e-02 1.255 0 0
MECP2 regulates transcription factors R-HSA-9022707 5.559081e-02 1.255 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 5.559081e-02 1.255 0 0
Cell-Cell communication R-HSA-1500931 5.617046e-02 1.250 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.698719e-02 1.244 1 0
Diseases of mitotic cell cycle R-HSA-9675126 5.750664e-02 1.240 0 0
Ephrin signaling R-HSA-3928664 5.762847e-02 1.239 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 5.762847e-02 1.239 0 0
PKA activation R-HSA-163615 5.762847e-02 1.239 0 0
PKA activation in glucagon signalling R-HSA-164378 5.762847e-02 1.239 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 5.762847e-02 1.239 0 0
Signaling by FGFR R-HSA-190236 5.767679e-02 1.239 0 0
Platelet activation, signaling and aggregation R-HSA-76002 5.797154e-02 1.237 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 5.951215e-02 1.225 1 1
C-type lectin receptors (CLRs) R-HSA-5621481 6.046794e-02 1.218 1 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 6.093161e-02 1.215 0 0
Muscle contraction R-HSA-397014 6.099990e-02 1.215 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 6.201492e-02 1.208 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 6.201492e-02 1.208 0 0
Hedgehog 'off' state R-HSA-5610787 6.266717e-02 1.203 0 0
Intraflagellar transport R-HSA-5620924 6.323296e-02 1.199 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 6.326184e-02 1.199 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.374074e-02 1.196 0 0
The NLRP3 inflammasome R-HSA-844456 6.374074e-02 1.196 0 0
Rap1 signalling R-HSA-392517 6.374074e-02 1.196 0 0
Cell junction organization R-HSA-446728 6.387568e-02 1.195 0 0
Type I hemidesmosome assembly R-HSA-446107 6.565315e-02 1.183 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 6.565315e-02 1.183 0 0
SLC-mediated bile acid transport R-HSA-9958517 6.565315e-02 1.183 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 6.565315e-02 1.183 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 6.565315e-02 1.183 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 7.273749e-02 1.138 0 0
SARS-CoV-1 targets PDZ proteins in cell-cell junction R-HSA-9692912 7.273749e-02 1.138 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 7.273749e-02 1.138 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 7.273749e-02 1.138 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 7.681412e-02 1.115 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.681412e-02 1.115 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 8.375686e-02 1.077 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.375686e-02 1.077 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 8.374457e-02 1.077 0 0
Amplification of signal from the kinetochores R-HSA-141424 6.857166e-02 1.164 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 6.857166e-02 1.164 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 8.939776e-02 1.049 0 0
Centrosome maturation R-HSA-380287 9.747754e-02 1.011 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.661585e-02 1.116 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 7.161208e-02 1.145 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.840534e-02 1.007 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 8.374457e-02 1.077 0 0
PERK regulates gene expression R-HSA-381042 7.661585e-02 1.116 0 0
PI3K/AKT activation R-HSA-198203 8.737719e-02 1.059 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 7.157180e-02 1.145 0 0
PTEN Regulation R-HSA-6807070 7.558087e-02 1.122 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 8.375686e-02 1.077 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 9.095733e-02 1.041 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 7.799419e-02 1.108 1 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 7.013893e-02 1.154 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 9.849605e-02 1.007 0 0
Stabilization of p53 R-HSA-69541 9.849605e-02 1.007 0 0
DNA Double Strand Break Response R-HSA-5693606 6.746323e-02 1.171 0 0
G2/M DNA damage checkpoint R-HSA-69473 9.339038e-02 1.030 0 0
Mitophagy R-HSA-5205647 7.157180e-02 1.145 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.626678e-02 1.118 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 7.626678e-02 1.118 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 7.626678e-02 1.118 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 8.038241e-02 1.095 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 8.737719e-02 1.059 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.626678e-02 1.118 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 8.737719e-02 1.059 0 0
Gene expression (Transcription) R-HSA-74160 6.615894e-02 1.179 0 0
Metabolism of RNA R-HSA-8953854 7.335894e-02 1.135 0 0
Apoptosis R-HSA-109581 8.352469e-02 1.078 0 0
GP1b-IX-V activation signalling R-HSA-430116 7.626678e-02 1.118 0 0
RAF activation R-HSA-5673000 7.157180e-02 1.145 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 7.661585e-02 1.116 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 9.849605e-02 1.007 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.857166e-02 1.164 0 0
RUNX2 regulates bone development R-HSA-8941326 8.183342e-02 1.087 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 8.737719e-02 1.059 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 9.840534e-02 1.007 0 0
Signaling by ROBO receptors R-HSA-376176 8.251997e-02 1.083 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 8.737719e-02 1.059 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 9.480924e-02 1.023 1 0
MyD88-independent TLR4 cascade R-HSA-166166 9.480924e-02 1.023 1 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 7.921232e-02 1.101 1 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 8.737719e-02 1.059 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 8.375686e-02 1.077 0 0
Regulated Necrosis R-HSA-5218859 7.087594e-02 1.150 0 0
Opioid Signalling R-HSA-111885 7.343394e-02 1.134 0 0
Interleukin-1 processing R-HSA-448706 7.626678e-02 1.118 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 7.626678e-02 1.118 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 9.840534e-02 1.007 0 0
PI3K Cascade R-HSA-109704 7.105835e-02 1.148 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 7.626678e-02 1.118 0 0
Growth hormone receptor signaling R-HSA-982772 9.840534e-02 1.007 0 0
Mitochondrial calcium ion transport R-HSA-8949215 8.375686e-02 1.077 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 9.893311e-02 1.005 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 9.893311e-02 1.005 0 0
PECAM1 interactions R-HSA-210990 9.893311e-02 1.005 0 0
Cilium Assembly R-HSA-5617833 1.028236e-01 0.988 0 0
Attenuation phase R-HSA-3371568 1.043753e-01 0.981 0 0
Toll-like Receptor Cascades R-HSA-168898 1.054465e-01 0.977 1 0
TRAF6 mediated NF-kB activation R-HSA-933542 1.060904e-01 0.974 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 1.060904e-01 0.974 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 1.071006e-01 0.970 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 1.071006e-01 0.970 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 1.071006e-01 0.970 0 0
tRNA processing R-HSA-72306 1.071888e-01 0.970 0 0
SARS-CoV Infections R-HSA-9679506 1.074066e-01 0.969 1 0
Innate Immune System R-HSA-168249 1.078346e-01 0.967 1 0
Cardiac conduction R-HSA-5576891 1.089824e-01 0.963 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.104106e-01 0.957 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 1.108864e-01 0.955 0 0
Activation of RAC1 R-HSA-428540 1.108864e-01 0.955 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.108864e-01 0.955 0 0
Tight junction interactions R-HSA-420029 1.140019e-01 0.943 0 0
Acyl chain remodelling of PS R-HSA-1482801 1.140019e-01 0.943 0 0
Formation of the nephric duct R-HSA-9830364 1.140019e-01 0.943 0 0
Interleukin-7 signaling R-HSA-1266695 1.140019e-01 0.943 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.156313e-01 0.937 0 0
Neuronal System R-HSA-112316 1.192403e-01 0.924 0 0
Signaling by FGFR2 R-HSA-5654738 1.192988e-01 0.923 0 0
Death Receptor Signaling R-HSA-73887 1.209647e-01 0.917 1 0
Formation of paraxial mesoderm R-HSA-9793380 1.228918e-01 0.910 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.229332e-01 0.910 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.231919e-01 0.909 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 1.231919e-01 0.909 0 0
Interleukin-15 signaling R-HSA-8983432 1.231919e-01 0.909 0 0
GRB2 events in EGFR signaling R-HSA-179812 1.231919e-01 0.909 0 0
MET activates RAS signaling R-HSA-8851805 1.231919e-01 0.909 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 1.231919e-01 0.909 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 1.231919e-01 0.909 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 1.231919e-01 0.909 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.265369e-01 0.898 0 0
Rab regulation of trafficking R-HSA-9007101 1.269507e-01 0.896 0 0
Heme signaling R-HSA-9707616 1.282973e-01 0.892 0 0
Signaling by PDGF R-HSA-186797 1.282973e-01 0.892 0 0
Signaling by FGFR4 R-HSA-5654743 1.294118e-01 0.888 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.295808e-01 0.887 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 1.304605e-01 0.885 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.304605e-01 0.885 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 1.358072e-01 0.867 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.358072e-01 0.867 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 1.358072e-01 0.867 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.358072e-01 0.867 0 0
Interleukin-6 signaling R-HSA-1059683 1.358072e-01 0.867 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 1.358072e-01 0.867 0 0
DAP12 interactions R-HSA-2172127 1.360292e-01 0.866 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 1.389856e-01 0.857 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 1.389856e-01 0.857 0 0
Inflammasomes R-HSA-622312 1.389856e-01 0.857 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 1.394257e-01 0.856 1 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 1.401923e-01 0.853 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 1.401923e-01 0.853 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.401923e-01 0.853 0 0
MET activates STAT3 R-HSA-8875791 1.720595e-01 0.764 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 1.720595e-01 0.764 0 0
Invadopodia formation R-HSA-8941237 1.720595e-01 0.764 0 0
Signalling to STAT3 R-HSA-198745 1.720595e-01 0.764 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.027475e-01 0.693 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.027475e-01 0.693 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 2.027475e-01 0.693 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.322998e-01 0.634 0 0
FGFR1c and Klotho ligand binding and activation R-HSA-190374 2.322998e-01 0.634 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.322998e-01 0.634 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 2.322998e-01 0.634 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.607585e-01 0.584 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 2.607585e-01 0.584 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 2.022241e-01 0.694 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.297491e-01 0.639 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 2.436068e-01 0.613 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.436068e-01 0.613 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.436068e-01 0.613 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.436068e-01 0.613 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.436068e-01 0.613 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.496614e-01 0.825 0 0
FGFR2 alternative splicing R-HSA-6803529 2.852888e-01 0.545 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 2.852888e-01 0.545 0 0
HSF1 activation R-HSA-3371511 2.226135e-01 0.652 0 0
mRNA 3'-end processing R-HSA-72187 1.933832e-01 0.714 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.699543e-01 0.569 0 0
Neutrophil degranulation R-HSA-6798695 1.442221e-01 0.841 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.904417e-01 0.720 0 0
Co-inhibition by PD-1 R-HSA-389948 2.104012e-01 0.677 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.748030e-01 0.757 0 0
FGFR1 ligand binding and activation R-HSA-190242 2.159466e-01 0.666 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 2.852888e-01 0.545 0 0
Cellular response to starvation R-HSA-9711097 2.250459e-01 0.648 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 2.713972e-01 0.566 1 1
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.852888e-01 0.545 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 2.073100e-01 0.683 0 0
Regulation of gap junction activity R-HSA-191650 2.027475e-01 0.693 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.814359e-01 0.741 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.814359e-01 0.741 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.027475e-01 0.693 0 0
PTK6 Activates STAT3 R-HSA-8849474 2.322998e-01 0.634 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.324458e-01 0.634 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 2.027475e-01 0.693 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 2.027475e-01 0.693 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 2.607585e-01 0.584 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.841283e-01 0.735 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.485829e-01 0.605 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 1.443770e-01 0.841 0 0
Parasite infection R-HSA-9664407 1.443770e-01 0.841 0 0
Leishmania phagocytosis R-HSA-9664417 1.443770e-01 0.841 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.710304e-01 0.767 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.710304e-01 0.767 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.877889e-01 0.726 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 1.935838e-01 0.713 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.637913e-01 0.786 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.637913e-01 0.786 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.322998e-01 0.634 0 0
NTRK2 activates RAC1 R-HSA-9032759 2.322998e-01 0.634 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.607585e-01 0.584 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.607585e-01 0.584 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.618105e-01 0.791 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.618105e-01 0.791 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.841283e-01 0.735 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 2.226135e-01 0.652 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.841283e-01 0.735 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.794999e-01 0.746 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 2.815111e-01 0.551 0 0
TCR signaling R-HSA-202403 1.821072e-01 0.740 1 0
MET promotes cell motility R-HSA-8875878 2.424179e-01 0.615 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.551556e-01 0.593 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 2.027475e-01 0.693 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.436068e-01 0.613 0 0
GPER1 signaling R-HSA-9634597 1.637913e-01 0.786 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.783788e-01 0.749 0 0
ESR-mediated signaling R-HSA-8939211 1.795619e-01 0.746 0 0
RNA Polymerase II Transcription R-HSA-73857 2.227293e-01 0.652 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 2.031567e-01 0.692 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.324771e-01 0.634 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.618105e-01 0.791 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.506962e-01 0.822 0 0
Generic Transcription Pathway R-HSA-212436 1.654019e-01 0.781 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.128367e-01 0.672 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 1.720595e-01 0.764 0 0
NADE modulates death signalling R-HSA-205025 2.027475e-01 0.693 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.322998e-01 0.634 0 0
Physiological factors R-HSA-5578768 1.486925e-01 0.828 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.618105e-01 0.791 0 0
Negative regulation of FLT3 R-HSA-9706369 1.751266e-01 0.757 0 0
HATs acetylate histones R-HSA-3214847 2.387879e-01 0.622 0 0
Interleukin-1 signaling R-HSA-9020702 2.511262e-01 0.600 1 1
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.476933e-01 0.831 0 0
Smooth Muscle Contraction R-HSA-445355 2.010288e-01 0.697 0 0
MAP kinase activation R-HSA-450294 2.649513e-01 0.577 1 0
Interleukin-2 family signaling R-HSA-451927 2.624926e-01 0.581 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.607585e-01 0.584 0 0
NGF-stimulated transcription R-HSA-9031628 1.637913e-01 0.786 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.732098e-01 0.564 0 0
Chromatin organization R-HSA-4839726 1.453886e-01 0.837 0 0
Chromatin modifying enzymes R-HSA-3247509 1.696210e-01 0.771 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.877889e-01 0.726 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.629449e-01 0.580 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.573617e-01 0.589 0 0
Signal transduction by L1 R-HSA-445144 2.436068e-01 0.613 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 2.022241e-01 0.694 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.699543e-01 0.569 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.946744e-01 0.711 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 1.720595e-01 0.764 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 2.027475e-01 0.693 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.322998e-01 0.634 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 2.607585e-01 0.584 0 0
SHC1 events in EGFR signaling R-HSA-180336 1.618105e-01 0.791 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 1.886079e-01 0.724 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 2.574966e-01 0.589 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 2.713972e-01 0.566 0 0
Maturation of spike protein R-HSA-9694548 2.726084e-01 0.564 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.649513e-01 0.577 0 0
Cell-cell junction organization R-HSA-421270 1.512077e-01 0.820 0 0
Interleukin-1 family signaling R-HSA-446652 1.978759e-01 0.704 1 0
Zygotic genome activation (ZGA) R-HSA-9819196 2.574966e-01 0.589 0 0
Generation of second messenger molecules R-HSA-202433 2.624926e-01 0.581 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.942210e-01 0.712 0 0
p75NTR signals via NF-kB R-HSA-193639 1.618105e-01 0.791 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.945193e-01 0.711 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.945193e-01 0.711 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 2.713972e-01 0.566 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 2.852888e-01 0.545 0 0
Deubiquitination R-HSA-5688426 2.446560e-01 0.611 1 0
Signaling by FGFR3 R-HSA-5654741 1.427806e-01 0.845 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 2.088168e-01 0.680 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 2.607585e-01 0.584 0 0
Synthesis of PG R-HSA-1483148 1.886079e-01 0.724 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.841283e-01 0.735 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 2.852888e-01 0.545 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 2.827645e-01 0.549 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 2.827645e-01 0.549 0 0
GAB1 signalosome R-HSA-180292 2.159466e-01 0.666 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.159466e-01 0.666 0 0
Signaling by NOTCH2 R-HSA-1980145 2.031567e-01 0.692 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.726084e-01 0.564 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.803071e-01 0.744 0 0
Platelet degranulation R-HSA-114608 1.728838e-01 0.762 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 2.607585e-01 0.584 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.436068e-01 0.613 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 1.935838e-01 0.713 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 2.827645e-01 0.549 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.751650e-01 0.757 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.732098e-01 0.564 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.433227e-01 0.844 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.618105e-01 0.791 0 0
Interleukin-37 signaling R-HSA-9008059 1.565723e-01 0.805 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 2.436068e-01 0.613 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 1.886079e-01 0.724 0 0
Triglyceride metabolism R-HSA-8979227 2.485829e-01 0.605 0 0
Triglyceride catabolism R-HSA-163560 2.226135e-01 0.652 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.886079e-01 0.724 0 0
Phospholipid metabolism R-HSA-1483257 2.165611e-01 0.664 0 0
PI Metabolism R-HSA-1483255 2.573617e-01 0.589 0 0
Signaling by Hedgehog R-HSA-5358351 2.352046e-01 0.629 0 0
Tie2 Signaling R-HSA-210993 2.159466e-01 0.666 0 0
Signaling by FGFR4 in disease R-HSA-5655291 1.486925e-01 0.828 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.027879e-01 0.693 0 0
SLC transporter disorders R-HSA-5619102 1.668110e-01 0.778 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 2.860575e-01 0.544 0 0
STAT5 Activation R-HSA-9645135 2.881638e-01 0.540 0 0
Erythropoietin activates STAT5 R-HSA-9027283 2.881638e-01 0.540 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 2.881638e-01 0.540 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 2.881638e-01 0.540 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 2.881638e-01 0.540 0 0
Leukotriene receptors R-HSA-391906 2.881638e-01 0.540 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 2.881638e-01 0.540 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.891145e-01 0.539 0 0
Adherens junctions interactions R-HSA-418990 2.914716e-01 0.535 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.929525e-01 0.533 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 2.929525e-01 0.533 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 2.991529e-01 0.524 0 0
Interleukin-20 family signaling R-HSA-8854691 2.991529e-01 0.524 0 0
Syndecan interactions R-HSA-3000170 2.991529e-01 0.524 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.020433e-01 0.520 0 0
Ub-specific processing proteases R-HSA-5689880 3.033378e-01 0.518 1 1
Deadenylation of mRNA R-HSA-429947 3.129727e-01 0.504 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 3.129727e-01 0.504 0 0
Interleukin-6 family signaling R-HSA-6783589 3.129727e-01 0.504 0 0
Proteasome assembly R-HSA-9907900 3.133913e-01 0.504 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.145548e-01 0.502 0 0
Regulation of PTEN localization R-HSA-8948747 3.145548e-01 0.502 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.145548e-01 0.502 0 0
Recycling of eIF2:GDP R-HSA-72731 3.145548e-01 0.502 0 0
Disinhibition of SNARE formation R-HSA-114516 3.145548e-01 0.502 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 3.145548e-01 0.502 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.145548e-01 0.502 0 0
Netrin mediated repulsion signals R-HSA-418886 3.145548e-01 0.502 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 3.145548e-01 0.502 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 3.145548e-01 0.502 0 0
DNA Double-Strand Break Repair R-HSA-5693532 3.204573e-01 0.494 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.234956e-01 0.490 0 0
Somitogenesis R-HSA-9824272 3.236264e-01 0.490 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.236264e-01 0.490 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 3.236264e-01 0.490 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 3.267322e-01 0.486 0 0
Long-term potentiation R-HSA-9620244 3.267322e-01 0.486 0 0
TGFBR3 expression R-HSA-9839394 3.267322e-01 0.486 0 0
HDMs demethylate histones R-HSA-3214842 3.267322e-01 0.486 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 3.338620e-01 0.476 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 3.338620e-01 0.476 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 3.338620e-01 0.476 0 0
Signaling by TGFBR3 R-HSA-9839373 3.338620e-01 0.476 0 0
FGFR1b ligand binding and activation R-HSA-190370 3.399689e-01 0.469 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 3.399689e-01 0.469 0 0
Interleukin-23 signaling R-HSA-9020933 3.399689e-01 0.469 0 0
Formation of annular gap junctions R-HSA-196025 3.399689e-01 0.469 0 0
Co-stimulation by ICOS R-HSA-9927354 3.399689e-01 0.469 0 0
Interleukin-9 signaling R-HSA-8985947 3.399689e-01 0.469 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 3.399689e-01 0.469 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 3.399689e-01 0.469 0 0
TGFBR3 PTM regulation R-HSA-9839383 3.399689e-01 0.469 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 3.399689e-01 0.469 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 3.399689e-01 0.469 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.399689e-01 0.469 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.399689e-01 0.469 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 3.404171e-01 0.468 0 0
Metalloprotease DUBs R-HSA-5689901 3.404171e-01 0.468 0 0
Sphingolipid catabolism R-HSA-9845614 3.404171e-01 0.468 0 0
Interleukin-17 signaling R-HSA-448424 3.404268e-01 0.468 1 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 3.440908e-01 0.463 0 0
Synthesis of PC R-HSA-1483191 3.440908e-01 0.463 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.489043e-01 0.457 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 3.540140e-01 0.451 0 0
Cristae formation R-HSA-8949613 3.540140e-01 0.451 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.540140e-01 0.451 1 1
SHC-mediated cascade:FGFR2 R-HSA-5654699 3.540140e-01 0.451 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 3.540140e-01 0.451 0 0
Signaling by FGFR3 in disease R-HSA-5655332 3.540140e-01 0.451 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 3.546266e-01 0.450 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.573842e-01 0.447 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 3.573842e-01 0.447 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 3.577264e-01 0.446 1 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.644422e-01 0.438 0 0
ARMS-mediated activation R-HSA-170984 3.644422e-01 0.438 0 0
ALK mutants bind TKIs R-HSA-9700645 3.644422e-01 0.438 0 0
Gap junction degradation R-HSA-190873 3.644422e-01 0.438 0 0
Calcineurin activates NFAT R-HSA-2025928 3.644422e-01 0.438 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 3.644422e-01 0.438 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 3.644422e-01 0.438 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 3.644422e-01 0.438 1 1
Activation of the AP-1 family of transcription factors R-HSA-450341 3.644422e-01 0.438 0 0
Interleukin-21 signaling R-HSA-9020958 3.644422e-01 0.438 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 3.644422e-01 0.438 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 3.644422e-01 0.438 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.644422e-01 0.438 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 3.644422e-01 0.438 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.644422e-01 0.438 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.644422e-01 0.438 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.644422e-01 0.438 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.644422e-01 0.438 0 0
DNA Damage Bypass R-HSA-73893 3.645009e-01 0.438 0 0
Ca2+ pathway R-HSA-4086398 3.658625e-01 0.437 1 1
Switching of origins to a post-replicative state R-HSA-69052 3.658625e-01 0.437 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 3.675106e-01 0.435 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 3.675106e-01 0.435 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 3.675106e-01 0.435 0 0
Signaling by ERBB4 R-HSA-1236394 3.743352e-01 0.427 0 0
Signaling by FGFR2 in disease R-HSA-5655253 3.746692e-01 0.426 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 3.790011e-01 0.421 1 1
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 3.808957e-01 0.419 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.808957e-01 0.419 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 3.808957e-01 0.419 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.808957e-01 0.419 0 0
Termination of translesion DNA synthesis R-HSA-5656169 3.808957e-01 0.419 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 3.808957e-01 0.419 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 3.808957e-01 0.419 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.863994e-01 0.413 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 3.863994e-01 0.413 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 3.880095e-01 0.411 0 0
2-LTR circle formation R-HSA-164843 3.880095e-01 0.411 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 3.880095e-01 0.411 1 1
Ion influx/efflux at host-pathogen interface R-HSA-6803544 3.880095e-01 0.411 0 0
Interleukin-27 signaling R-HSA-9020956 3.880095e-01 0.411 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 3.880095e-01 0.411 0 0
Maturation of spike protein R-HSA-9683686 3.880095e-01 0.411 0 0
Receptor Mediated Mitophagy R-HSA-8934903 3.880095e-01 0.411 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.941590e-01 0.404 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.941590e-01 0.404 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 3.941590e-01 0.404 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 3.949019e-01 0.404 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 3.949019e-01 0.404 0 0
Translation of Structural Proteins R-HSA-9694635 3.996818e-01 0.398 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 4.049549e-01 0.393 0 0
Amino acids regulate mTORC1 R-HSA-9639288 4.049549e-01 0.393 0 0
EGFR downregulation R-HSA-182971 4.072912e-01 0.390 0 0
Trafficking of AMPA receptors R-HSA-399719 4.072912e-01 0.390 0 0
Budding and maturation of HIV virion R-HSA-162588 4.072912e-01 0.390 0 0
Cargo concentration in the ER R-HSA-5694530 4.072912e-01 0.390 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 4.072912e-01 0.390 0 0
Nuclear Receptor transcription pathway R-HSA-383280 4.080947e-01 0.389 0 0
PCP/CE pathway R-HSA-4086400 4.080947e-01 0.389 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.107042e-01 0.386 0 0
vRNP Assembly R-HSA-192905 4.107042e-01 0.386 0 0
Synthesis of PI R-HSA-1483226 4.107042e-01 0.386 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 4.107042e-01 0.386 1 1
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.107042e-01 0.386 0 0
Interleukin-2 signaling R-HSA-9020558 4.107042e-01 0.386 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 4.149585e-01 0.382 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 4.159185e-01 0.381 0 0
Viral Infection Pathways R-HSA-9824446 4.192627e-01 0.378 1 0
G0 and Early G1 R-HSA-1538133 4.202838e-01 0.376 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.249076e-01 0.372 0 0
Signaling by NOTCH3 R-HSA-9012852 4.249076e-01 0.372 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.325587e-01 0.364 0 0
Signaling by GSK3beta mutants R-HSA-5339716 4.325587e-01 0.364 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 4.325587e-01 0.364 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 4.325587e-01 0.364 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 4.325587e-01 0.364 0 0
NF-kB is activated and signals survival R-HSA-209560 4.325587e-01 0.364 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.325587e-01 0.364 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 4.325587e-01 0.364 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 4.325587e-01 0.364 0 0
Sodium/Calcium exchangers R-HSA-425561 4.325587e-01 0.364 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 4.325587e-01 0.364 0 0
Integration of provirus R-HSA-162592 4.325587e-01 0.364 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 4.325587e-01 0.364 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 4.331291e-01 0.363 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 4.331291e-01 0.363 0 0
G-protein beta:gamma signalling R-HSA-397795 4.331291e-01 0.363 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 4.331291e-01 0.363 0 0
Regulation of necroptotic cell death R-HSA-5675482 4.331291e-01 0.363 0 0
Processing of DNA double-strand break ends R-HSA-5693607 4.331781e-01 0.363 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 4.347976e-01 0.362 0 0
Ion homeostasis R-HSA-5578775 4.347976e-01 0.362 0 0
NRAGE signals death through JNK R-HSA-193648 4.347976e-01 0.362 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 4.347976e-01 0.362 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 4.347976e-01 0.362 0 0
TNF signaling R-HSA-75893 4.347976e-01 0.362 1 0
Leishmania parasite growth and survival R-HSA-9664433 4.386042e-01 0.358 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 4.386042e-01 0.358 0 0
Resolution of D-Loop Structures R-HSA-5693537 4.458202e-01 0.351 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 4.458202e-01 0.351 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 4.458202e-01 0.351 0 0
G2/M Checkpoints R-HSA-69481 4.474795e-01 0.349 0 0
MITF-M-dependent gene expression R-HSA-9856651 4.489284e-01 0.348 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 4.536040e-01 0.343 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 4.536040e-01 0.343 0 0
Scavenging by Class F Receptors R-HSA-3000484 4.536040e-01 0.343 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 4.536040e-01 0.343 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 4.536040e-01 0.343 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 4.536040e-01 0.343 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 4.536040e-01 0.343 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.536040e-01 0.343 0 0
IRAK1 recruits IKK complex R-HSA-937039 4.536040e-01 0.343 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 4.536040e-01 0.343 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 4.536040e-01 0.343 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 4.536040e-01 0.343 0 0
Signaling by LTK R-HSA-9842663 4.536040e-01 0.343 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 4.536040e-01 0.343 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 4.536040e-01 0.343 0 0
Pervasive developmental disorders R-HSA-9005895 4.536040e-01 0.343 0 0
Disorders of Nervous System Development R-HSA-9697154 4.536040e-01 0.343 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 4.536040e-01 0.343 0 0
Interleukin-35 Signalling R-HSA-8984722 4.536040e-01 0.343 0 0
p75NTR recruits signalling complexes R-HSA-209543 4.536040e-01 0.343 0 0
OAS antiviral response R-HSA-8983711 4.536040e-01 0.343 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 4.543818e-01 0.343 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 4.549625e-01 0.342 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 4.583508e-01 0.339 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 4.583508e-01 0.339 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 4.583508e-01 0.339 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 4.583508e-01 0.339 0 0
NOD1/2 Signaling Pathway R-HSA-168638 4.583508e-01 0.339 1 1
NPAS4 regulates expression of target genes R-HSA-9768919 4.583508e-01 0.339 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 4.609884e-01 0.336 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 4.707154e-01 0.327 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 4.707154e-01 0.327 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.729795e-01 0.325 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 4.736777e-01 0.325 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 4.736777e-01 0.325 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 4.736777e-01 0.325 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 4.736777e-01 0.325 0 0
RAB geranylgeranylation R-HSA-8873719 4.736777e-01 0.325 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 4.736777e-01 0.325 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 4.738700e-01 0.324 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 4.738700e-01 0.324 0 0
FGFR1c ligand binding and activation R-HSA-190373 4.738700e-01 0.324 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 4.738700e-01 0.324 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 4.738700e-01 0.324 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 4.738700e-01 0.324 0 0
Formation of axial mesoderm R-HSA-9796292 4.738700e-01 0.324 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 4.738700e-01 0.324 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 4.738700e-01 0.324 0 0
Maturation of nucleoprotein R-HSA-9683610 4.738700e-01 0.324 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 4.738700e-01 0.324 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 4.829091e-01 0.316 0 0
Aquaporin-mediated transport R-HSA-445717 4.832081e-01 0.316 0 0
Post-translational protein modification R-HSA-597592 4.893914e-01 0.310 1 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 4.926555e-01 0.307 0 0
Mitochondrial protein import R-HSA-1268020 4.926555e-01 0.307 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 4.933856e-01 0.307 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 4.933856e-01 0.307 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 4.933856e-01 0.307 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 4.933856e-01 0.307 1 1
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 4.933856e-01 0.307 0 0
Retrograde neurotrophin signalling R-HSA-177504 4.933856e-01 0.307 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 4.933856e-01 0.307 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.933856e-01 0.307 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 4.933856e-01 0.307 0 0
NRIF signals cell death from the nucleus R-HSA-205043 4.933856e-01 0.307 0 0
Non-canonical inflammasome activation R-HSA-9686114 4.933856e-01 0.307 0 0
Signal regulatory protein family interactions R-HSA-391160 4.933856e-01 0.307 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 4.933856e-01 0.307 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.949276e-01 0.305 0 0
Infectious disease R-HSA-5663205 5.004394e-01 0.301 1 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 5.020167e-01 0.299 0 0
ER-Phagosome pathway R-HSA-1236974 5.063304e-01 0.296 0 0
Disease R-HSA-1643685 5.063800e-01 0.296 1 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 5.067671e-01 0.295 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 5.067671e-01 0.295 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 5.067671e-01 0.295 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 5.067671e-01 0.295 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 5.121783e-01 0.291 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.121783e-01 0.291 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 5.121783e-01 0.291 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.121783e-01 0.291 1 1
Lysosphingolipid and LPA receptors R-HSA-419408 5.121783e-01 0.291 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 5.121783e-01 0.291 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 5.121783e-01 0.291 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 5.121783e-01 0.291 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 5.121783e-01 0.291 0 0
Cell-extracellular matrix interactions R-HSA-446353 5.121783e-01 0.291 0 0
Downstream TCR signaling R-HSA-202424 5.142077e-01 0.289 1 1
MITF-M-regulated melanocyte development R-HSA-9730414 5.181469e-01 0.286 0 0
RAS processing R-HSA-9648002 5.184243e-01 0.285 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 5.184243e-01 0.285 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 5.184243e-01 0.285 0 0
Ion channel transport R-HSA-983712 5.271898e-01 0.278 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 5.298965e-01 0.276 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 5.298965e-01 0.276 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 5.298965e-01 0.276 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 5.302751e-01 0.275 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 5.302751e-01 0.275 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 5.302751e-01 0.275 0 0
Killing mechanisms R-HSA-9664420 5.302751e-01 0.275 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.302751e-01 0.275 0 0
Prolonged ERK activation events R-HSA-169893 5.302751e-01 0.275 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 5.302751e-01 0.275 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.302751e-01 0.275 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 5.302751e-01 0.275 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 5.302751e-01 0.275 0 0
Unfolded Protein Response (UPR) R-HSA-381119 5.372159e-01 0.270 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 5.374818e-01 0.270 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 5.374818e-01 0.270 0 0
Kidney development R-HSA-9830369 5.385436e-01 0.269 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 5.411814e-01 0.267 0 0
Assembly of the pre-replicative complex R-HSA-68867 5.451144e-01 0.264 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 5.477016e-01 0.261 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 5.477016e-01 0.261 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 5.477016e-01 0.261 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 5.477016e-01 0.261 0 0
Heme assimilation R-HSA-9927020 5.477016e-01 0.261 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.477016e-01 0.261 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 5.477016e-01 0.261 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.477016e-01 0.261 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 5.477016e-01 0.261 0 0
tRNA modification in the mitochondrion R-HSA-6787450 5.477016e-01 0.261 0 0
Disorders of Developmental Biology R-HSA-9675151 5.477016e-01 0.261 0 0
Mitochondrial biogenesis R-HSA-1592230 5.506946e-01 0.259 0 0
Negative regulation of MAPK pathway R-HSA-5675221 5.522771e-01 0.258 0 0
Intra-Golgi traffic R-HSA-6811438 5.522771e-01 0.258 0 0
Translation of Structural Proteins R-HSA-9683701 5.522771e-01 0.258 0 0
Disorders of transmembrane transporters R-HSA-5619115 5.532977e-01 0.257 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 5.631820e-01 0.249 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 5.640418e-01 0.249 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 5.644826e-01 0.248 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 5.644826e-01 0.248 0 0
COPII-mediated vesicle transport R-HSA-204005 5.649082e-01 0.248 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 5.734896e-01 0.241 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 5.734896e-01 0.241 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 5.738951e-01 0.241 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.749744e-01 0.240 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 5.771856e-01 0.239 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 5.806420e-01 0.236 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 5.806420e-01 0.236 0 0
Apoptotic factor-mediated response R-HSA-111471 5.806420e-01 0.236 0 0
Polo-like kinase mediated events R-HSA-156711 5.806420e-01 0.236 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 5.806420e-01 0.236 0 0
Cyclin D associated events in G1 R-HSA-69231 5.844156e-01 0.233 0 0
G1 Phase R-HSA-69236 5.844156e-01 0.233 0 0
Post-translational protein phosphorylation R-HSA-8957275 5.894826e-01 0.230 0 0
Regulation of insulin secretion R-HSA-422356 5.894826e-01 0.230 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 5.947430e-01 0.226 0 0
Regulation of signaling by CBL R-HSA-912631 5.962028e-01 0.225 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 5.962028e-01 0.225 0 0
Germ layer formation at gastrulation R-HSA-9754189 5.962028e-01 0.225 0 0
E2F mediated regulation of DNA replication R-HSA-113510 5.962028e-01 0.225 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 5.962028e-01 0.225 0 0
Specification of the neural plate border R-HSA-9834899 5.962028e-01 0.225 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 5.962028e-01 0.225 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 5.962028e-01 0.225 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 5.962028e-01 0.225 0 0
STING mediated induction of host immune responses R-HSA-1834941 5.962028e-01 0.225 0 0
Maturation of nucleoprotein R-HSA-9694631 5.962028e-01 0.225 0 0
Other interleukin signaling R-HSA-449836 5.962028e-01 0.225 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 5.962028e-01 0.225 0 0
Formation of the cornified envelope R-HSA-6809371 5.965012e-01 0.224 0 0
S Phase R-HSA-69242 5.973040e-01 0.224 0 0
Signaling by NOTCH4 R-HSA-9013694 5.985919e-01 0.223 0 0
Diseases of DNA repair R-HSA-9675135 6.048772e-01 0.218 0 0
Regulation of TNFR1 signaling R-HSA-5357905 6.048772e-01 0.218 0 0
Potential therapeutics for SARS R-HSA-9679191 6.088152e-01 0.216 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 6.111871e-01 0.214 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.111871e-01 0.214 0 0
Negative regulation of MET activity R-HSA-6807004 6.111871e-01 0.214 0 0
Formation of definitive endoderm R-HSA-9823730 6.111871e-01 0.214 0 0
Synthesis of Ketone Bodies R-HSA-77111 6.111871e-01 0.214 0 0
Protein hydroxylation R-HSA-9629569 6.111871e-01 0.214 0 0
Nephrin family interactions R-HSA-373753 6.111871e-01 0.214 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 6.111871e-01 0.214 0 0
Signaling by NOTCH1 R-HSA-1980143 6.147803e-01 0.211 0 0
Gluconeogenesis R-HSA-70263 6.245667e-01 0.204 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 6.256162e-01 0.204 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 6.256162e-01 0.204 1 1
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 6.256162e-01 0.204 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 6.256162e-01 0.204 0 0
Early Phase of HIV Life Cycle R-HSA-162594 6.256162e-01 0.204 0 0
G alpha (q) signalling events R-HSA-416476 6.304318e-01 0.200 0 0
Interleukin-10 signaling R-HSA-6783783 6.305231e-01 0.200 0 0
SLC-mediated transport of organic anions R-HSA-9955298 6.305231e-01 0.200 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 6.341229e-01 0.198 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 6.395107e-01 0.194 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 6.395107e-01 0.194 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 6.395107e-01 0.194 0 0
Assembly Of The HIV Virion R-HSA-175474 6.395107e-01 0.194 0 0
Epigenetic regulation of gene expression R-HSA-212165 6.439573e-01 0.191 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 6.458155e-01 0.190 0 0
Cellular response to chemical stress R-HSA-9711123 6.475392e-01 0.189 0 0
G alpha (i) signalling events R-HSA-418594 6.498592e-01 0.187 0 0
Adipogenesis R-HSA-9843745 6.513539e-01 0.186 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 6.526625e-01 0.185 1 1
Meiotic recombination R-HSA-912446 6.526625e-01 0.185 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 6.528903e-01 0.185 0 0
Notch-HLH transcription pathway R-HSA-350054 6.528903e-01 0.185 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 6.528903e-01 0.185 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 6.528903e-01 0.185 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 6.529817e-01 0.185 1 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 6.532918e-01 0.185 0 0
Peptide ligand-binding receptors R-HSA-375276 6.553225e-01 0.184 0 0
Circadian clock R-HSA-9909396 6.571478e-01 0.182 0 0
Synthesis of DNA R-HSA-69239 6.574710e-01 0.182 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 6.616481e-01 0.179 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 6.616481e-01 0.179 0 0
Signaling by TGFB family members R-HSA-9006936 6.635327e-01 0.178 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 6.638355e-01 0.178 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 6.638355e-01 0.178 0 0
Antigen processing-Cross presentation R-HSA-1236975 6.638355e-01 0.178 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 6.651007e-01 0.177 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 6.657742e-01 0.177 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 6.657742e-01 0.177 0 0
Interleukin receptor SHC signaling R-HSA-912526 6.657742e-01 0.177 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 6.657742e-01 0.177 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 6.657742e-01 0.177 0 0
Biosynthesis of maresins R-HSA-9018682 6.657742e-01 0.177 0 0
Formation of the ureteric bud R-HSA-9830674 6.657742e-01 0.177 0 0
Organic anion transport by SLCO transporters R-HSA-879518 6.657742e-01 0.177 0 0
Ketone body metabolism R-HSA-74182 6.657742e-01 0.177 0 0
DNA Replication Pre-Initiation R-HSA-69002 6.701190e-01 0.174 0 0
CYP2E1 reactions R-HSA-211999 6.781806e-01 0.169 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 6.781806e-01 0.169 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 6.781806e-01 0.169 0 0
Neurodegenerative Diseases R-HSA-8863678 6.781806e-01 0.169 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 6.781806e-01 0.169 0 0
Translation initiation complex formation R-HSA-72649 6.790579e-01 0.168 0 0
Integration of energy metabolism R-HSA-163685 6.851792e-01 0.164 0 0
Signaling by Nuclear Receptors R-HSA-9006931 6.880672e-01 0.162 0 0
FCERI mediated MAPK activation R-HSA-2871796 6.884820e-01 0.162 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 6.901271e-01 0.161 0 0
G protein gated Potassium channels R-HSA-1296059 6.901271e-01 0.161 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 6.901271e-01 0.161 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 6.901271e-01 0.161 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 6.901271e-01 0.161 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 6.901271e-01 0.161 0 0
Laminin interactions R-HSA-3000157 6.901271e-01 0.161 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 6.901271e-01 0.161 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 6.905959e-01 0.161 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 6.957301e-01 0.158 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 7.003162e-01 0.155 0 0
MET activates PTK2 signaling R-HSA-8874081 7.016310e-01 0.154 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 7.016310e-01 0.154 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.016310e-01 0.154 0 0
TRP channels R-HSA-3295583 7.016310e-01 0.154 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 7.016310e-01 0.154 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.016310e-01 0.154 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 7.016310e-01 0.154 0 0
Synthesis of PA R-HSA-1483166 7.037943e-01 0.153 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 7.061108e-01 0.151 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 7.116798e-01 0.148 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 7.116798e-01 0.148 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.127084e-01 0.147 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 7.127084e-01 0.147 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 7.127084e-01 0.147 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 7.127084e-01 0.147 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 7.127084e-01 0.147 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.127084e-01 0.147 0 0
Triglyceride biosynthesis R-HSA-75109 7.127084e-01 0.147 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 7.127084e-01 0.147 0 0
Extension of Telomeres R-HSA-180786 7.193888e-01 0.143 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 7.193888e-01 0.143 0 0
G alpha (s) signalling events R-HSA-418555 7.225037e-01 0.141 0 0
Cap-dependent Translation Initiation R-HSA-72737 7.230054e-01 0.141 0 0
Eukaryotic Translation Initiation R-HSA-72613 7.230054e-01 0.141 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 7.233752e-01 0.141 0 0
HIV elongation arrest and recovery R-HSA-167287 7.233752e-01 0.141 0 0
Formation of the Early Elongation Complex R-HSA-113418 7.233752e-01 0.141 0 0
Pausing and recovery of HIV elongation R-HSA-167290 7.233752e-01 0.141 0 0
Telomere Extension By Telomerase R-HSA-171319 7.233752e-01 0.141 0 0
Insulin receptor recycling R-HSA-77387 7.233752e-01 0.141 0 0
Iron assimilation using enterobactin R-HSA-9638334 7.233752e-01 0.141 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 7.269236e-01 0.139 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 7.280582e-01 0.138 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 7.280582e-01 0.138 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 7.328553e-01 0.135 1 0
mRNA Capping R-HSA-72086 7.336466e-01 0.135 0 0
Platelet calcium homeostasis R-HSA-418360 7.336466e-01 0.135 0 0
Homology Directed Repair R-HSA-5693538 7.338623e-01 0.134 0 0
rRNA processing R-HSA-72312 7.349128e-01 0.134 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 7.412444e-01 0.130 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 7.414797e-01 0.130 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 7.435372e-01 0.129 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.435372e-01 0.129 0 0
Activation of BH3-only proteins R-HSA-114452 7.435372e-01 0.129 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 7.435372e-01 0.129 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 7.435372e-01 0.129 0 0
Neurotransmitter clearance R-HSA-112311 7.435372e-01 0.129 0 0
Activation of the pre-replicative complex R-HSA-68962 7.435372e-01 0.129 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.530611e-01 0.123 0 0
Gastrulation R-HSA-9758941 7.551925e-01 0.122 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.622319e-01 0.118 0 0
Signaling by WNT in cancer R-HSA-4791275 7.622319e-01 0.118 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 7.622319e-01 0.118 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 7.710626e-01 0.113 0 0
Cardiogenesis R-HSA-9733709 7.710626e-01 0.113 0 0
DNA Repair R-HSA-73894 7.713089e-01 0.113 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 7.749891e-01 0.111 0 0
Striated Muscle Contraction R-HSA-390522 7.795659e-01 0.108 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 7.795659e-01 0.108 0 0
Acyl chain remodelling of PC R-HSA-1482788 7.795659e-01 0.108 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 7.795659e-01 0.108 0 0
Asparagine N-linked glycosylation R-HSA-446203 7.841659e-01 0.106 0 0
FOXO-mediated transcription R-HSA-9614085 7.845039e-01 0.105 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 7.872944e-01 0.104 0 0
Dual Incision in GG-NER R-HSA-5696400 7.877539e-01 0.104 0 0
eNOS activation R-HSA-203615 7.877539e-01 0.104 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 7.877539e-01 0.104 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 7.877539e-01 0.104 0 0
Calnexin/calreticulin cycle R-HSA-901042 7.877539e-01 0.104 0 0
Signal amplification R-HSA-392518 7.877539e-01 0.104 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 7.932222e-01 0.101 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 7.940272e-01 0.100 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 7.956382e-01 0.099 0 0
Regulation of Apoptosis R-HSA-169911 7.956382e-01 0.099 0 0
Acyl chain remodelling of PE R-HSA-1482839 7.956382e-01 0.099 0 0
GPCR downstream signalling R-HSA-388396 7.989706e-01 0.097 0 0
Metal ion assimilation from the host R-HSA-9638482 7.990037e-01 0.097 0 0
Glycosphingolipid transport R-HSA-9845576 8.032300e-01 0.095 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.032300e-01 0.095 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 8.046416e-01 0.094 0 0
Voltage gated Potassium channels R-HSA-1296072 8.105403e-01 0.091 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 8.105403e-01 0.091 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.105403e-01 0.091 0 0
SLC-mediated transport of organic cations R-HSA-549127 8.105403e-01 0.091 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 8.105403e-01 0.091 0 0
Collagen chain trimerization R-HSA-8948216 8.105403e-01 0.091 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 8.134769e-01 0.090 0 0
Activation of HOX genes during differentiation R-HSA-5619507 8.134769e-01 0.090 0 0
tRNA processing in the mitochondrion R-HSA-6785470 8.175795e-01 0.087 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 8.203105e-01 0.086 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 8.207201e-01 0.086 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 8.243575e-01 0.084 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 8.243575e-01 0.084 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.243575e-01 0.084 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 8.243575e-01 0.084 0 0
UCH proteinases R-HSA-5689603 8.258102e-01 0.083 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 8.258102e-01 0.083 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 8.308841e-01 0.080 0 0
HIV Transcription Elongation R-HSA-167169 8.308841e-01 0.080 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 8.308841e-01 0.080 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 8.308841e-01 0.080 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.308841e-01 0.080 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 8.308841e-01 0.080 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 8.308841e-01 0.080 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.308841e-01 0.080 0 0
rRNA processing in the mitochondrion R-HSA-8868766 8.308841e-01 0.080 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 8.308841e-01 0.080 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.348413e-01 0.078 0 0
RNA Polymerase I Transcription R-HSA-73864 8.356022e-01 0.078 0 0
G alpha (12/13) signalling events R-HSA-416482 8.356022e-01 0.078 0 0
Integrin cell surface interactions R-HSA-216083 8.356022e-01 0.078 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 8.371685e-01 0.077 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.371685e-01 0.077 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.371685e-01 0.077 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.371685e-01 0.077 0 0
Developmental Cell Lineages R-HSA-9734767 8.376462e-01 0.077 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 8.406518e-01 0.075 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.432198e-01 0.074 0 0
HIV Transcription Initiation R-HSA-167161 8.432198e-01 0.074 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.432198e-01 0.074 0 0
Heme biosynthesis R-HSA-189451 8.432198e-01 0.074 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.432198e-01 0.074 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.432198e-01 0.074 0 0
Signaling by WNT R-HSA-195721 8.480161e-01 0.072 1 0
GABA B receptor activation R-HSA-977444 8.490466e-01 0.071 0 0
Activation of GABAB receptors R-HSA-991365 8.490466e-01 0.071 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 8.490466e-01 0.071 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 8.507100e-01 0.070 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.546571e-01 0.068 0 0
TBC/RABGAPs R-HSA-8854214 8.546571e-01 0.068 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.579403e-01 0.067 0 0
Signaling by NOTCH R-HSA-157118 8.599768e-01 0.066 0 0
RMTs methylate histone arginines R-HSA-3214858 8.600595e-01 0.065 0 0
Surfactant metabolism R-HSA-5683826 8.600595e-01 0.065 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 8.600595e-01 0.065 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 8.650698e-01 0.063 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.652613e-01 0.063 0 0
Fanconi Anemia Pathway R-HSA-6783310 8.652613e-01 0.063 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.652613e-01 0.063 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.652613e-01 0.063 0 0
Meiosis R-HSA-1500620 8.660725e-01 0.062 0 0
Protein-protein interactions at synapses R-HSA-6794362 8.660725e-01 0.062 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 8.702701e-01 0.060 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.702701e-01 0.060 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 8.702701e-01 0.060 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.702701e-01 0.060 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 8.737757e-01 0.059 0 0
XBP1(S) activates chaperone genes R-HSA-381038 8.737757e-01 0.059 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.750930e-01 0.058 0 0
Metal ion SLC transporters R-HSA-425410 8.797369e-01 0.056 0 0
Peptide chain elongation R-HSA-156902 8.810693e-01 0.055 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 8.810693e-01 0.055 0 0
Diseases of programmed cell death R-HSA-9645723 8.810693e-01 0.055 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.832617e-01 0.054 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 8.842084e-01 0.053 0 0
Chemokine receptors bind chemokines R-HSA-380108 8.842084e-01 0.053 0 0
Signaling by GPCR R-HSA-372790 8.851610e-01 0.053 0 0
Protein localization R-HSA-9609507 8.864131e-01 0.052 0 0
DNA Replication R-HSA-69306 8.864131e-01 0.052 0 0
Azathioprine ADME R-HSA-9748787 8.885140e-01 0.051 0 0
PPARA activates gene expression R-HSA-1989781 8.916163e-01 0.050 0 0
Neddylation R-HSA-8951664 8.920030e-01 0.050 0 0
The phototransduction cascade R-HSA-2514856 8.926596e-01 0.049 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 8.945015e-01 0.048 0 0
IRE1alpha activates chaperones R-HSA-381070 8.945015e-01 0.048 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.966097e-01 0.047 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 8.966514e-01 0.047 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 8.966514e-01 0.047 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 8.966514e-01 0.047 0 0
Neurexins and neuroligins R-HSA-6794361 8.966514e-01 0.047 0 0
Eukaryotic Translation Elongation R-HSA-156842 8.976320e-01 0.047 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 8.984699e-01 0.046 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 8.984699e-01 0.046 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 8.984699e-01 0.046 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 9.004949e-01 0.046 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.004949e-01 0.046 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 9.004949e-01 0.046 0 0
Meiotic synapsis R-HSA-1221632 9.004949e-01 0.046 0 0
FCGR activation R-HSA-2029481 9.006759e-01 0.045 0 0
Collagen formation R-HSA-1474290 9.036353e-01 0.044 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.065122e-01 0.043 0 0
HDACs deacetylate histones R-HSA-3214815 9.077592e-01 0.042 0 0
G alpha (z) signalling events R-HSA-418597 9.077592e-01 0.042 0 0
Paracetamol ADME R-HSA-9753281 9.077592e-01 0.042 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.093087e-01 0.041 0 0
Eukaryotic Translation Termination R-HSA-72764 9.093087e-01 0.041 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.093087e-01 0.041 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 9.111903e-01 0.040 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.111903e-01 0.040 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.120267e-01 0.040 0 0
Potassium Channels R-HSA-1296071 9.120267e-01 0.040 0 0
Dectin-2 family R-HSA-5621480 9.144939e-01 0.039 0 0
Telomere Maintenance R-HSA-157579 9.146683e-01 0.039 0 0
Dual incision in TC-NER R-HSA-6782135 9.176749e-01 0.037 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.176749e-01 0.037 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.178790e-01 0.037 0 0
Peroxisomal protein import R-HSA-9033241 9.207377e-01 0.036 0 0
Regulation of beta-cell development R-HSA-186712 9.207377e-01 0.036 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.207377e-01 0.036 0 0
GABA receptor activation R-HSA-977443 9.236867e-01 0.034 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.236867e-01 0.034 0 0
tRNA Aminoacylation R-HSA-379724 9.236867e-01 0.034 0 0
Selenocysteine synthesis R-HSA-2408557 9.245078e-01 0.034 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.265262e-01 0.033 0 0
Collagen degradation R-HSA-1442490 9.265262e-01 0.033 0 0
Regulation of endogenous retroelements R-HSA-9842860 9.267951e-01 0.033 0 0
Keratinization R-HSA-6805567 9.284716e-01 0.032 0 0
Viral mRNA Translation R-HSA-192823 9.290170e-01 0.032 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.318926e-01 0.031 0 0
Ribosome-associated quality control R-HSA-9948299 9.320212e-01 0.031 0 0
RSV-host interactions R-HSA-9833110 9.332709e-01 0.030 0 0
Xenobiotics R-HSA-211981 9.344273e-01 0.029 0 0
Cellular response to hypoxia R-HSA-1234174 9.368677e-01 0.028 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.392021e-01 0.027 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.392175e-01 0.027 0 0
Stimuli-sensing channels R-HSA-2672351 9.410655e-01 0.026 0 0
Nicotinate metabolism R-HSA-196807 9.414799e-01 0.026 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.414799e-01 0.026 0 0
Transcription of the HIV genome R-HSA-167172 9.436583e-01 0.025 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.436583e-01 0.025 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.438913e-01 0.025 1 1
Antimicrobial peptides R-HSA-6803157 9.463356e-01 0.024 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 9.477752e-01 0.023 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.477752e-01 0.023 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 9.477752e-01 0.023 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.479904e-01 0.023 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.479904e-01 0.023 0 0
Metabolism of cofactors R-HSA-8978934 9.497195e-01 0.022 0 0
Metabolism of porphyrins R-HSA-189445 9.497195e-01 0.022 0 0
Aspirin ADME R-HSA-9749641 9.533942e-01 0.021 0 0
Extracellular matrix organization R-HSA-1474244 9.543835e-01 0.020 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.550902e-01 0.020 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 9.551297e-01 0.020 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.551297e-01 0.020 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.568007e-01 0.019 0 0
Protein ubiquitination R-HSA-8852135 9.568007e-01 0.019 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.599585e-01 0.018 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.628859e-01 0.016 0 0
Chromosome Maintenance R-HSA-73886 9.632568e-01 0.016 0 0
Amyloid fiber formation R-HSA-977225 9.655996e-01 0.015 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.655996e-01 0.015 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.656375e-01 0.015 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.681152e-01 0.014 0 0
G1/S Transition R-HSA-69206 9.686774e-01 0.014 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.693033e-01 0.014 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 9.693033e-01 0.014 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.693033e-01 0.014 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.715484e-01 0.013 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.726087e-01 0.012 0 0
Pyruvate metabolism R-HSA-70268 9.736296e-01 0.012 0 0
Reproduction R-HSA-1474165 9.741699e-01 0.011 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.750885e-01 0.011 0 0
Metabolism of proteins R-HSA-392499 9.770092e-01 0.010 1 0
Mitochondrial protein degradation R-HSA-9837999 9.805412e-01 0.009 0 0
Scavenging of heme from plasma R-HSA-2168880 9.819655e-01 0.008 0 0
TCF dependent signaling in response to WNT R-HSA-201681 9.821259e-01 0.008 0 0
Mitochondrial translation elongation R-HSA-5389840 9.826381e-01 0.008 0 0
Mitochondrial translation initiation R-HSA-5368286 9.839091e-01 0.007 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.845093e-01 0.007 0 0
ABC-family proteins mediated transport R-HSA-382556 9.850871e-01 0.007 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.866948e-01 0.006 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.873949e-01 0.006 0 0
Bacterial Infection Pathways R-HSA-9824439 9.875275e-01 0.005 0 0
Nucleotide Excision Repair R-HSA-5696398 9.881294e-01 0.005 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.881995e-01 0.005 0 0
Platelet homeostasis R-HSA-418346 9.885724e-01 0.005 0 0
Sphingolipid metabolism R-HSA-428157 9.895487e-01 0.005 0 0
Mitochondrial translation termination R-HSA-5419276 9.898048e-01 0.004 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.901854e-01 0.004 0 0
Selenoamino acid metabolism R-HSA-2408522 9.920746e-01 0.003 0 0
Interferon alpha/beta signaling R-HSA-909733 9.924805e-01 0.003 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.924805e-01 0.003 0 0
Peptide hormone metabolism R-HSA-2980736 9.930317e-01 0.003 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.944548e-01 0.002 0 0
Transport of small molecules R-HSA-382551 9.946214e-01 0.002 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.957559e-01 0.002 0 0
Sensory perception of taste R-HSA-9717189 9.962114e-01 0.002 0 0
Mitochondrial translation R-HSA-5368287 9.972071e-01 0.001 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.977782e-01 0.001 0 0
Infection with Enterobacteria R-HSA-9640148 9.979484e-01 0.001 0 0
Visual phototransduction R-HSA-2187338 9.980926e-01 0.001 0 0
Translation R-HSA-72766 9.981324e-01 0.001 0 0
GPCR ligand binding R-HSA-500792 9.983311e-01 0.001 0 0
Arachidonate metabolism R-HSA-2142753 9.984239e-01 0.001 0 0
Interferon gamma signaling R-HSA-877300 9.987934e-01 0.001 0 0
Drug ADME R-HSA-9748784 9.988157e-01 0.001 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.990876e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.991110e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.991903e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999261e-01 0.000 0 0
Metabolism of lipids R-HSA-556833 9.999669e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999716e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999933e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 9.999986e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999990e-01 0.000 0 0
Biological oxidations R-HSA-211859 9.999998e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Attenuation phase R-HSA-3371568 1.110223e-16 15.955 0 0
HSF1-dependent transactivation R-HSA-3371571 1.110223e-16 15.955 0 0
Cellular response to heat stress R-HSA-3371556 1.110223e-16 15.955 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.110223e-16 15.955 0 0
Axon guidance R-HSA-422475 1.110223e-16 15.955 0 0
Nervous system development R-HSA-9675108 1.110223e-16 15.955 0 0
Cell-Cell communication R-HSA-1500931 1.110223e-16 15.955 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.110223e-16 15.955 1 0
Cellular responses to stimuli R-HSA-8953897 1.110223e-16 15.955 0 0
Cellular responses to stress R-HSA-2262752 1.110223e-16 15.955 0 0
HSF1 activation R-HSA-3371511 1.776357e-15 14.750 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.331468e-15 14.632 0 0
EPH-Ephrin signaling R-HSA-2682334 2.775558e-15 14.557 0 0
M Phase R-HSA-68886 2.997602e-15 14.523 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.110223e-14 13.955 0 0
Developmental Biology R-HSA-1266738 1.298961e-14 13.886 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.609823e-14 13.793 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.720846e-14 13.764 0 0
Signaling by VEGF R-HSA-194138 2.697842e-14 13.569 0 0
Viral Infection Pathways R-HSA-9824446 2.764455e-14 13.558 1 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 4.618528e-14 13.335 0 0
Aggrephagy R-HSA-9646399 1.024736e-13 12.989 0 0
Signal Transduction R-HSA-162582 3.989031e-13 12.399 1 0
Cell Cycle, Mitotic R-HSA-69278 7.233103e-13 12.141 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 7.898127e-13 12.102 0 0
Cell Cycle R-HSA-1640170 8.654188e-13 12.063 0 0
Cell junction organization R-HSA-446728 1.797784e-12 11.745 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.498335e-12 11.602 0 0
Signaling by ERBB2 R-HSA-1227986 2.874700e-12 11.541 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.859357e-12 11.413 0 0
Metabolism of RNA R-HSA-8953854 6.784129e-12 11.169 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.516154e-11 10.819 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.516154e-11 10.819 0 0
PKR-mediated signaling R-HSA-9833482 1.730283e-11 10.762 0 0
Signaling by Interleukins R-HSA-449147 3.018219e-11 10.520 1 0
Immune System R-HSA-168256 3.498646e-11 10.456 1 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.104188e-10 9.957 0 0
Signaling by ROBO receptors R-HSA-376176 2.702846e-10 9.568 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.892016e-10 9.539 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.964539e-10 9.528 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 3.156553e-10 9.501 0 0
Regulation of CDH1 Function R-HSA-9764561 3.128510e-10 9.505 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 3.437338e-10 9.464 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.749817e-10 9.426 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 4.686945e-10 9.329 0 0
Apoptosis R-HSA-109581 5.150895e-10 9.288 0 0
Post NMDA receptor activation events R-HSA-438064 5.467971e-10 9.262 0 0
Selective autophagy R-HSA-9663891 6.725095e-10 9.172 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 7.053408e-10 9.152 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 7.128489e-10 9.147 0 0
Infectious disease R-HSA-5663205 1.013156e-09 8.994 1 0
mRNA Splicing R-HSA-72172 1.158506e-09 8.936 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.207364e-09 8.918 0 0
G2/M Checkpoints R-HSA-69481 1.381933e-09 8.860 0 0
Mitotic Anaphase R-HSA-68882 1.498886e-09 8.824 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.684529e-09 8.774 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.829993e-09 8.738 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.820653e-09 8.740 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.887515e-09 8.724 1 0
Adherens junctions interactions R-HSA-418990 1.891817e-09 8.723 0 0
Separation of Sister Chromatids R-HSA-2467813 2.438216e-09 8.613 0 0
Cell-cell junction organization R-HSA-421270 2.512388e-09 8.600 0 0
Interferon Signaling R-HSA-913531 3.325544e-09 8.478 0 0
TCR signaling R-HSA-202403 3.507798e-09 8.455 1 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.892775e-09 8.410 0 0
Programmed Cell Death R-HSA-5357801 4.219053e-09 8.375 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 6.002895e-09 8.222 0 0
Ribosome-associated quality control R-HSA-9948299 9.699879e-09 8.013 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.022414e-08 7.990 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.140876e-08 7.943 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.250234e-08 7.903 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.283946e-08 7.891 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.283946e-08 7.891 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.328317e-08 7.877 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.447772e-08 7.839 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.683490e-08 7.774 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.727138e-08 7.763 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.810957e-08 7.742 0 0
DNA Double Strand Break Response R-HSA-5693606 1.935435e-08 7.713 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.208671e-08 7.656 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.578444e-08 7.589 0 0
Interleukin-12 signaling R-HSA-9020591 2.545735e-08 7.594 0 0
Recycling pathway of L1 R-HSA-437239 2.803216e-08 7.552 0 0
Autophagy R-HSA-9612973 3.495340e-08 7.457 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 3.560510e-08 7.448 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 4.145558e-08 7.382 0 0
G2/M Transition R-HSA-69275 4.185324e-08 7.378 0 0
L1CAM interactions R-HSA-373760 4.929460e-08 7.307 0 0
Macroautophagy R-HSA-1632852 5.183306e-08 7.285 0 0
Mitotic G2-G2/M phases R-HSA-453274 5.244010e-08 7.280 0 0
SARS-CoV-2 Infection R-HSA-9694516 5.083751e-08 7.294 1 0
Interleukin-12 family signaling R-HSA-447115 5.343554e-08 7.272 0 0
G2/M DNA damage checkpoint R-HSA-69473 8.025601e-08 7.096 0 0
RAF/MAP kinase cascade R-HSA-5673001 9.688636e-08 7.014 0 0
Protein ubiquitination R-HSA-8852135 9.711669e-08 7.013 0 0
MAPK family signaling cascades R-HSA-5683057 1.079956e-07 6.967 0 0
Cell Cycle Checkpoints R-HSA-69620 1.163937e-07 6.934 0 0
Ephrin signaling R-HSA-3928664 1.183071e-07 6.927 0 0
Apoptotic execution phase R-HSA-75153 1.247714e-07 6.904 0 0
SARS-CoV Infections R-HSA-9679506 1.372647e-07 6.862 1 0
Signaling by ALK in cancer R-HSA-9700206 1.374613e-07 6.862 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.374613e-07 6.862 0 0
Protein folding R-HSA-391251 1.485551e-07 6.828 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.575601e-07 6.803 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.595256e-07 6.797 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.800472e-07 6.745 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.759444e-07 6.755 0 0
Regulation of signaling by CBL R-HSA-912631 1.796780e-07 6.746 0 0
Disease R-HSA-1643685 1.803509e-07 6.744 1 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.864783e-07 6.729 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.014972e-07 6.696 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.039658e-07 6.690 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.109499e-07 6.676 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.405960e-07 6.619 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.415925e-07 6.617 0 0
Gap junction trafficking and regulation R-HSA-157858 2.540900e-07 6.595 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.587488e-07 6.587 0 0
Peptide chain elongation R-HSA-156902 2.664639e-07 6.574 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.664639e-07 6.574 0 0
Mitotic Prometaphase R-HSA-68877 2.707570e-07 6.567 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.846614e-07 6.546 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.846614e-07 6.546 0 0
Mitotic Prophase R-HSA-68875 3.157384e-07 6.501 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.285024e-07 6.483 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.355160e-07 6.474 0 0
ESR-mediated signaling R-HSA-8939211 3.402850e-07 6.468 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.531934e-07 6.452 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 3.609676e-07 6.443 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 3.919541e-07 6.407 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 3.919541e-07 6.407 0 0
Gap junction trafficking R-HSA-190828 4.266387e-07 6.370 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 5.061275e-07 6.296 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 5.128231e-07 6.290 0 0
Co-inhibition by PD-1 R-HSA-389948 5.486695e-07 6.261 0 0
Assembly of the pre-replicative complex R-HSA-68867 6.888869e-07 6.162 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 7.075239e-07 6.150 0 0
Translation initiation complex formation R-HSA-72649 7.550351e-07 6.122 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 7.819721e-07 6.107 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 8.877066e-07 6.052 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 8.877066e-07 6.052 0 0
Gap junction assembly R-HSA-190861 8.877066e-07 6.052 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.105787e-07 6.041 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 9.175985e-07 6.037 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.032086e-06 5.986 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.045682e-06 5.981 0 0
HCMV Early Events R-HSA-9609690 1.049239e-06 5.979 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.093045e-06 5.961 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.132647e-06 5.946 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.191069e-06 5.924 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.197495e-06 5.922 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.368119e-06 5.864 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.547654e-06 5.810 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 1.547654e-06 5.810 0 0
Neutrophil degranulation R-HSA-6798695 1.549854e-06 5.810 0 0
Influenza Infection R-HSA-168255 1.592322e-06 5.798 0 0
Signaling by SCF-KIT R-HSA-1433557 1.811169e-06 5.742 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 2.029801e-06 5.693 1 0
Hedgehog 'off' state R-HSA-5610787 2.191176e-06 5.659 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.379265e-06 5.624 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.379265e-06 5.624 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.411477e-06 5.618 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.485488e-06 5.605 0 0
Ub-specific processing proteases R-HSA-5689880 2.507831e-06 5.601 1 1
Signaling by EGFR in Cancer R-HSA-1643713 2.847380e-06 5.546 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.875092e-06 5.541 0 0
Meiotic synapsis R-HSA-1221632 2.953963e-06 5.530 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 3.264699e-06 5.486 1 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.808683e-06 5.419 0 0
Packaging Of Telomere Ends R-HSA-171306 3.799178e-06 5.420 0 0
Semaphorin interactions R-HSA-373755 4.166709e-06 5.380 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 4.172700e-06 5.380 1 0
RNA Polymerase I Promoter Opening R-HSA-73728 3.799178e-06 5.420 0 0
Signaling by PTK6 R-HSA-8848021 4.166709e-06 5.380 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.166709e-06 5.380 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 4.531416e-06 5.344 0 0
FLT3 Signaling R-HSA-9607240 4.833339e-06 5.316 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 4.833339e-06 5.316 0 0
Membrane Trafficking R-HSA-199991 5.066854e-06 5.295 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 5.159998e-06 5.287 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 5.159998e-06 5.287 0 0
Signaling by KIT in disease R-HSA-9669938 5.753288e-06 5.240 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 5.753288e-06 5.240 0 0
Host Interactions of HIV factors R-HSA-162909 5.771503e-06 5.239 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 6.186986e-06 5.209 0 0
Degradation of CDH1 R-HSA-9766229 6.335853e-06 5.198 0 0
DNA methylation R-HSA-5334118 6.565862e-06 5.183 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 6.930598e-06 5.159 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 7.265536e-06 5.139 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 7.426591e-06 5.129 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 8.194089e-06 5.086 0 0
Oncogenic MAPK signaling R-HSA-6802957 8.424556e-06 5.074 0 0
GPVI-mediated activation cascade R-HSA-114604 8.263131e-06 5.083 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.263131e-06 5.083 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 8.874420e-06 5.052 0 0
Innate Immune System R-HSA-168249 8.907759e-06 5.050 1 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 9.134806e-06 5.039 0 0
Estrogen-dependent gene expression R-HSA-9018519 9.801753e-06 5.009 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.115694e-05 4.952 0 0
Signaling by Hedgehog R-HSA-5358351 1.206898e-05 4.918 0 0
Adaptive Immune System R-HSA-1280218 1.215609e-05 4.915 1 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.265407e-05 4.898 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.336639e-05 4.874 0 0
Smooth Muscle Contraction R-HSA-445355 1.336639e-05 4.874 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.358429e-05 4.867 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.371549e-05 4.863 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.374877e-05 4.862 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.374877e-05 4.862 0 0
Eukaryotic Translation Termination R-HSA-72764 1.374877e-05 4.862 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.396332e-05 4.855 0 0
Nef and signal transduction R-HSA-164944 1.453409e-05 4.838 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.545465e-05 4.811 0 0
Signaling by RAS mutants R-HSA-6802949 1.650124e-05 4.782 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.650124e-05 4.782 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.650124e-05 4.782 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.650124e-05 4.782 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.545465e-05 4.811 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.545465e-05 4.811 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.545465e-05 4.811 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.696692e-05 4.770 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.767555e-05 4.753 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.775996e-05 4.751 0 0
PECAM1 interactions R-HSA-210990 1.783330e-05 4.749 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.783330e-05 4.749 0 0
Downstream TCR signaling R-HSA-202424 1.908051e-05 4.719 1 1
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 1.991519e-05 4.701 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.011107e-05 4.697 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 2.320727e-05 4.634 0 0
Co-stimulation by CD28 R-HSA-389356 2.393276e-05 4.621 0 0
Translation R-HSA-72766 2.485938e-05 4.605 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.638041e-05 4.579 0 0
Homology Directed Repair R-HSA-5693538 2.819669e-05 4.550 0 0
Selenocysteine synthesis R-HSA-2408557 2.875432e-05 4.541 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.930236e-05 4.533 0 0
Meiosis R-HSA-1500620 3.012269e-05 4.521 0 0
Regulation of RAS by GAPs R-HSA-5658442 3.414221e-05 4.467 0 0
Cellular Senescence R-HSA-2559583 3.480729e-05 4.458 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.551311e-05 4.450 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 3.551311e-05 4.450 0 0
Depyrimidination R-HSA-73928 3.551311e-05 4.450 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 4.125411e-05 4.385 0 0
PRC2 methylates histones and DNA R-HSA-212300 4.237195e-05 4.373 0 0
Viral mRNA Translation R-HSA-192823 3.632063e-05 4.440 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 4.054192e-05 4.392 1 1
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 4.125411e-05 4.385 0 0
RNA Polymerase I Transcription R-HSA-73864 4.160054e-05 4.381 0 0
HCMV Infection R-HSA-9609646 3.835711e-05 4.416 0 0
Meiotic recombination R-HSA-912446 4.054192e-05 4.392 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 3.686321e-05 4.433 0 0
PCP/CE pathway R-HSA-4086400 4.160054e-05 4.381 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 4.290225e-05 4.368 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 4.290225e-05 4.368 0 0
Kinesins R-HSA-983189 4.290225e-05 4.368 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 4.408765e-05 4.356 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 4.465051e-05 4.350 0 0
DAP12 signaling R-HSA-2424491 4.774453e-05 4.321 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.774453e-05 4.321 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 4.967252e-05 4.304 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 5.129057e-05 4.290 1 1
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 5.142936e-05 4.289 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 5.190913e-05 4.285 0 0
Cleavage of the damaged purine R-HSA-110331 5.190913e-05 4.285 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 5.405708e-05 4.267 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.498583e-05 4.260 0 0
DNA Replication R-HSA-69306 5.571649e-05 4.254 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 5.715459e-05 4.243 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 5.975971e-05 4.224 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 6.147592e-05 4.211 0 0
Nucleosome assembly R-HSA-774815 6.147592e-05 4.211 0 0
Amyloid fiber formation R-HSA-977225 6.180101e-05 4.209 0 0
Depurination R-HSA-73927 6.323393e-05 4.199 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 6.352217e-05 4.197 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 7.074625e-05 4.150 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 7.317313e-05 4.136 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 7.317313e-05 4.136 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 8.695090e-05 4.061 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 8.695090e-05 4.061 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 8.695090e-05 4.061 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 8.695090e-05 4.061 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 8.695090e-05 4.061 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 8.695090e-05 4.061 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 8.695090e-05 4.061 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 8.695090e-05 4.061 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 8.695090e-05 4.061 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 8.695090e-05 4.061 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 8.695090e-05 4.061 0 0
Regulation of KIT signaling R-HSA-1433559 8.548636e-05 4.068 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 7.661369e-05 4.116 0 0
Signaling by Nuclear Receptors R-HSA-9006931 8.833431e-05 4.054 0 0
Signaling by NOTCH4 R-HSA-9013694 8.584822e-05 4.066 0 0
Signaling by WNT R-HSA-195721 8.052613e-05 4.094 1 0
ER to Golgi Anterograde Transport R-HSA-199977 8.709956e-05 4.060 0 0
Signaling by EGFR R-HSA-177929 9.073609e-05 4.042 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.234512e-05 4.035 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 9.234512e-05 4.035 0 0
HIV Infection R-HSA-162906 9.443300e-05 4.025 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.867149e-05 4.006 0 0
Nephrin family interactions R-HSA-373753 1.037178e-04 3.984 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.107562e-04 3.956 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.107562e-04 3.956 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.109271e-04 3.955 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.113429e-04 3.953 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 1.148990e-04 3.940 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.189795e-04 3.925 0 0
Protein methylation R-HSA-8876725 1.189795e-04 3.925 0 0
Deubiquitination R-HSA-5688426 1.211421e-04 3.917 1 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.322080e-04 3.879 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 1.322080e-04 3.879 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 1.322080e-04 3.879 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.353377e-04 3.869 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.367553e-04 3.864 0 0
Hemostasis R-HSA-109582 1.421029e-04 3.847 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.496353e-04 3.825 0 0
Death Receptor Signaling R-HSA-73887 1.578445e-04 3.802 1 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.617113e-04 3.791 0 0
Diseases of programmed cell death R-HSA-9645723 1.630659e-04 3.788 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 1.657721e-04 3.780 0 0
Regulation of Apoptosis R-HSA-169911 1.657721e-04 3.780 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 1.742327e-04 3.759 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.762482e-04 3.754 0 0
Interferon alpha/beta signaling R-HSA-909733 1.762771e-04 3.754 0 0
Telomere Maintenance R-HSA-157579 1.779924e-04 3.750 0 0
Signaling by FGFR2 R-HSA-5654738 1.826784e-04 3.738 0 0
Defective pyroptosis R-HSA-9710421 1.858555e-04 3.731 0 0
Gene Silencing by RNA R-HSA-211000 1.881373e-04 3.726 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.918721e-04 3.717 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 1.988768e-04 3.701 0 0
FLT3 signaling in disease R-HSA-9682385 1.996466e-04 3.700 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 1.996466e-04 3.700 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 2.007809e-04 3.697 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 2.178721e-04 3.662 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 2.348688e-04 3.629 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 2.348688e-04 3.629 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 2.391522e-04 3.621 0 0
Degradation of DVL R-HSA-4641258 2.391522e-04 3.621 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.391522e-04 3.621 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.573300e-04 3.590 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 2.573300e-04 3.590 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 2.618311e-04 3.582 1 0
Syndecan interactions R-HSA-3000170 2.801243e-04 3.553 0 0
Regulation of PTEN localization R-HSA-8948747 2.851214e-04 3.545 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.876653e-04 3.541 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.876653e-04 3.541 0 0
Signaling by Hippo R-HSA-2028269 2.876653e-04 3.541 0 0
Signaling by ERBB4 R-HSA-1236394 2.908330e-04 3.536 0 0
EGFR downregulation R-HSA-182971 2.973738e-04 3.527 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.978248e-04 3.526 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 3.626758e-04 3.440 0 0
Generation of second messenger molecules R-HSA-202433 3.989387e-04 3.399 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 3.965077e-04 3.402 0 0
Glycogen metabolism R-HSA-8982491 3.989387e-04 3.399 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 3.672557e-04 3.435 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.029864e-04 3.395 0 0
Sema4D in semaphorin signaling R-HSA-400685 4.335806e-04 3.363 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 4.386712e-04 3.358 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 4.415617e-04 3.355 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 4.462847e-04 3.350 0 0
CD28 dependent Vav1 pathway R-HSA-389359 4.531722e-04 3.344 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 4.531722e-04 3.344 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 4.637379e-04 3.334 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 4.687666e-04 3.329 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 4.717944e-04 3.326 0 0
Translesion Synthesis by POLH R-HSA-110320 4.808254e-04 3.318 0 0
Signaling by NOTCH R-HSA-157118 4.822679e-04 3.317 0 0
Vpu mediated degradation of CD4 R-HSA-180534 5.180842e-04 3.286 0 0
Vesicle-mediated transport R-HSA-5653656 5.235607e-04 3.281 0 0
Cellular response to starvation R-HSA-9711097 5.305194e-04 3.275 0 0
Degradation of CRY and PER proteins R-HSA-9932298 5.484457e-04 3.261 0 0
MAP2K and MAPK activation R-HSA-5674135 5.484457e-04 3.261 0 0
Platelet degranulation R-HSA-114608 5.621318e-04 3.250 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 5.778540e-04 3.238 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 5.876635e-04 3.231 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 5.880511e-04 3.231 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 5.880511e-04 3.231 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 5.880511e-04 3.231 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 6.162168e-04 3.210 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 6.162168e-04 3.210 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 6.207120e-04 3.207 0 0
Hedgehog ligand biogenesis R-HSA-5358346 6.207120e-04 3.207 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 6.308028e-04 3.200 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 6.475246e-04 3.189 1 1
Regulation of mitotic cell cycle R-HSA-453276 6.600773e-04 3.180 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 6.600773e-04 3.180 0 0
Orc1 removal from chromatin R-HSA-68949 7.106904e-04 3.148 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 7.290454e-04 3.137 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 7.290454e-04 3.137 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 7.393980e-04 3.131 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 7.408053e-04 3.130 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 7.415966e-04 3.130 0 0
Spry regulation of FGF signaling R-HSA-1295596 8.044048e-04 3.095 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 8.044048e-04 3.095 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.044048e-04 3.095 0 0
p75NTR signals via NF-kB R-HSA-193639 8.044048e-04 3.095 0 0
Chromosome Maintenance R-HSA-73886 8.061352e-04 3.094 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 8.061352e-04 3.094 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 8.112492e-04 3.091 0 0
Selenoamino acid metabolism R-HSA-2408522 8.151890e-04 3.089 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 8.265861e-04 3.083 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 8.356265e-04 3.078 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 8.356265e-04 3.078 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 8.573619e-04 3.067 0 0
DAP12 interactions R-HSA-2172127 8.573619e-04 3.067 0 0
Regulation of TP53 Degradation R-HSA-6804757 8.581696e-04 3.066 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 9.507515e-04 3.022 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.507515e-04 3.022 1 1
Signaling by Erythropoietin R-HSA-9006335 9.439102e-04 3.025 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 9.439102e-04 3.025 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 9.231453e-04 3.035 1 1
HDACs deacetylate histones R-HSA-3214815 1.047909e-03 2.980 0 0
Response of endothelial cells to shear stress R-HSA-9860931 9.974729e-04 3.001 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.166393e-03 2.933 0 0
Josephin domain DUBs R-HSA-5689877 9.231453e-04 3.035 0 0
DNA Repair R-HSA-73894 1.066743e-03 2.972 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.133534e-03 2.946 0 0
Degradation of AXIN R-HSA-4641257 1.005290e-03 2.998 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.875667e-04 3.005 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.027006e-03 2.988 0 0
Cellular response to chemical stress R-HSA-9711123 1.128315e-03 2.948 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 9.743319e-04 3.011 0 0
Maturation of protein E R-HSA-9683683 1.166393e-03 2.933 0 0
Maturation of protein E R-HSA-9694493 1.166393e-03 2.933 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.875667e-04 3.005 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.875667e-04 3.005 0 0
Activation of BH3-only proteins R-HSA-114452 1.126937e-03 2.948 0 0
MHC class II antigen presentation R-HSA-2132295 9.488271e-04 3.023 0 0
mTORC1-mediated signalling R-HSA-166208 1.169507e-03 2.932 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.182780e-03 2.927 0 0
TNF signaling R-HSA-75893 1.186039e-03 2.926 1 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.277691e-03 2.894 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.277691e-03 2.894 1 1
Beta-catenin independent WNT signaling R-HSA-3858494 1.324084e-03 2.878 1 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.335812e-03 2.874 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.335812e-03 2.874 0 0
Downstream signal transduction R-HSA-186763 1.337220e-03 2.874 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.360819e-03 2.866 0 0
Stabilization of p53 R-HSA-69541 1.360819e-03 2.866 0 0
Intraflagellar transport R-HSA-5620924 1.478406e-03 2.830 0 0
Signaling by FGFR R-HSA-190236 1.568418e-03 2.805 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 1.573127e-03 2.803 0 0
DNA Damage Bypass R-HSA-73893 1.680309e-03 2.775 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.680309e-03 2.775 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.680309e-03 2.775 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 1.685541e-03 2.773 0 0
NF-kB is activated and signals survival R-HSA-209560 1.723866e-03 2.763 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.724073e-03 2.763 0 0
Base Excision Repair R-HSA-73884 1.730464e-03 2.762 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.780034e-03 2.750 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 1.811222e-03 2.742 0 0
Interleukin-1 family signaling R-HSA-446652 1.874375e-03 2.727 1 0
Interleukin-1 signaling R-HSA-9020702 2.026861e-03 2.693 1 1
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.074927e-03 2.683 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.077292e-03 2.683 0 0
Cilium Assembly R-HSA-5617833 2.081775e-03 2.682 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.100718e-03 2.678 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 2.120007e-03 2.674 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.160224e-03 2.666 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.169622e-03 2.664 1 1
p75NTR recruits signalling complexes R-HSA-209543 2.274776e-03 2.643 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.321250e-03 2.634 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 2.364207e-03 2.626 0 0
MTOR signalling R-HSA-165159 2.373613e-03 2.625 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 2.423324e-03 2.616 0 0
mRNA 3'-end processing R-HSA-72187 2.423324e-03 2.616 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 2.423324e-03 2.616 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 2.423324e-03 2.616 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.469052e-03 2.607 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.472404e-03 2.607 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.472404e-03 2.607 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.472404e-03 2.607 0 0
Dual Incision in GG-NER R-HSA-5696400 2.508806e-03 2.601 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 2.508806e-03 2.601 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 2.630694e-03 2.580 0 0
rRNA processing R-HSA-72312 2.640453e-03 2.578 0 0
Signaling by FGFR4 R-HSA-5654743 2.702547e-03 2.568 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 2.702547e-03 2.568 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 2.722553e-03 2.565 0 0
RNA Polymerase II Transcription R-HSA-73857 2.754673e-03 2.560 0 0
Gene expression (Transcription) R-HSA-74160 2.810669e-03 2.551 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 2.830577e-03 2.548 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.915212e-03 2.535 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.943774e-03 2.531 0 0
Centrosome maturation R-HSA-380287 3.000796e-03 2.523 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 3.050612e-03 2.516 0 0
Negative regulation of MET activity R-HSA-6807004 3.157248e-03 2.501 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.157248e-03 2.501 0 0
Signal transduction by L1 R-HSA-445144 3.157248e-03 2.501 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.157248e-03 2.501 0 0
S Phase R-HSA-69242 3.219576e-03 2.492 0 0
Cellular response to hypoxia R-HSA-1234174 3.236369e-03 2.490 0 0
Developmental Cell Lineages R-HSA-9734767 3.293310e-03 2.482 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 3.409425e-03 2.467 0 0
DAG and IP3 signaling R-HSA-1489509 3.468116e-03 2.460 0 0
Signaling by FGFR3 R-HSA-5654741 3.468116e-03 2.460 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.468116e-03 2.460 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 3.468116e-03 2.460 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 3.468116e-03 2.460 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 3.656284e-03 2.437 0 0
Modulation by Mtb of host immune system R-HSA-9637628 3.656284e-03 2.437 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 3.656284e-03 2.437 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 3.744329e-03 2.427 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 3.744329e-03 2.427 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 3.744329e-03 2.427 1 1
NRIF signals cell death from the nucleus R-HSA-205043 3.744329e-03 2.427 0 0
Signal regulatory protein family interactions R-HSA-391160 3.744329e-03 2.427 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 3.744329e-03 2.427 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 3.800969e-03 2.420 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 3.800969e-03 2.420 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.800969e-03 2.420 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 3.813989e-03 2.419 1 1
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 3.909868e-03 2.408 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 3.909868e-03 2.408 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 3.998173e-03 2.398 0 0
Parasite infection R-HSA-9664407 3.998173e-03 2.398 0 0
Leishmania phagocytosis R-HSA-9664417 3.998173e-03 2.398 0 0
Late endosomal microautophagy R-HSA-9615710 4.004619e-03 2.397 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 4.067948e-03 2.391 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.123127e-03 2.385 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.900462e-03 2.310 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 6.537717e-03 2.185 0 0
Folding of actin by CCT/TriC R-HSA-390450 6.537717e-03 2.185 0 0
Erythropoietin activates RAS R-HSA-9027284 4.689877e-03 2.329 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 4.689877e-03 2.329 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 4.689877e-03 2.329 0 0
Negative regulation of FLT3 R-HSA-9706369 5.793704e-03 2.237 0 0
Translesion synthesis by POLI R-HSA-5656121 5.793704e-03 2.237 0 0
FGFR2 alternative splicing R-HSA-6803529 5.423801e-03 2.266 0 0
Dual incision in TC-NER R-HSA-6782135 4.690429e-03 2.329 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 6.336654e-03 2.198 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 6.537717e-03 2.185 0 0
Signaling by PDGFR in disease R-HSA-9671555 4.566858e-03 2.340 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 5.615797e-03 2.251 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 6.537717e-03 2.185 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 4.689877e-03 2.329 1 1
Translesion synthesis by REV1 R-HSA-110312 4.689877e-03 2.329 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 5.377651e-03 2.269 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 4.394459e-03 2.357 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 5.423801e-03 2.266 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 5.423801e-03 2.266 0 0
HATs acetylate histones R-HSA-3214847 4.364970e-03 2.360 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.377651e-03 2.269 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 6.339724e-03 2.198 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 6.392777e-03 2.194 0 0
Regulation of BACH1 activity R-HSA-9708530 5.793704e-03 2.237 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 6.322457e-03 2.199 0 0
Reproduction R-HSA-1474165 4.360813e-03 2.360 0 0
Hedgehog 'on' state R-HSA-5632684 5.748143e-03 2.240 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 4.965023e-03 2.304 0 0
Pexophagy R-HSA-9664873 6.537717e-03 2.185 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 6.592025e-03 2.181 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 6.592025e-03 2.181 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 6.592025e-03 2.181 0 0
G1/S Transition R-HSA-69206 6.592025e-03 2.181 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 6.809320e-03 2.167 0 0
Activation of HOX genes during differentiation R-HSA-5619507 6.809320e-03 2.167 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 7.068817e-03 2.151 0 0
Translesion synthesis by POLK R-HSA-5655862 7.068817e-03 2.151 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 7.068817e-03 2.151 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 7.068817e-03 2.151 0 0
Regulation of necroptotic cell death R-HSA-5675482 7.076416e-03 2.150 0 0
Muscle contraction R-HSA-397014 7.090395e-03 2.149 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 7.178544e-03 2.144 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 7.438561e-03 2.129 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 7.765593e-03 2.110 0 0
PTEN Regulation R-HSA-6807070 8.130202e-03 2.090 0 0
ChREBP activates metabolic gene expression R-HSA-163765 8.420074e-03 2.075 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 8.698423e-03 2.061 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 8.698423e-03 2.061 0 0
Long-term potentiation R-HSA-9620244 8.698423e-03 2.061 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.698423e-03 2.061 0 0
UCH proteinases R-HSA-5689603 8.840576e-03 2.054 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 9.086710e-03 2.042 0 0
NOD1/2 Signaling Pathway R-HSA-168638 9.143555e-03 2.039 1 1
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 9.692704e-03 2.014 0 0
Cyclin D associated events in G1 R-HSA-69231 9.939136e-03 2.003 0 0
G1 Phase R-HSA-69236 9.939136e-03 2.003 0 0
Myogenesis R-HSA-525793 1.005064e-02 1.998 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.018291e-02 1.992 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.062576e-02 1.974 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 1.062576e-02 1.974 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.070151e-02 1.971 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.070151e-02 1.971 0 0
Signaling by FGFR1 R-HSA-5654736 1.114767e-02 1.953 0 0
Glycolysis R-HSA-70171 1.118825e-02 1.951 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.122281e-02 1.950 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.131122e-02 1.946 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 1.154588e-02 1.938 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.154588e-02 1.938 1 1
Signaling by NTRK2 (TRKB) R-HSA-9006115 1.154588e-02 1.938 0 0
CaM pathway R-HSA-111997 1.162150e-02 1.935 0 0
Calmodulin induced events R-HSA-111933 1.162150e-02 1.935 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.196670e-02 1.922 0 0
Signaling by MET R-HSA-6806834 1.213318e-02 1.916 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.221713e-02 1.913 0 0
Transmission across Chemical Synapses R-HSA-112315 1.252058e-02 1.902 0 0
Manipulation of host energy metabolism R-HSA-9636667 1.259540e-02 1.900 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.259540e-02 1.900 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.302755e-02 1.885 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.317366e-02 1.880 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 1.317366e-02 1.880 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 1.317366e-02 1.880 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 1.317366e-02 1.880 0 0
IRAK1 recruits IKK complex R-HSA-937039 1.317366e-02 1.880 0 0
VLDLR internalisation and degradation R-HSA-8866427 1.317366e-02 1.880 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.319146e-02 1.880 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.393101e-02 1.856 0 0
Glycogen synthesis R-HSA-3322077 1.412678e-02 1.850 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.455175e-02 1.837 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.487724e-02 1.827 0 0
Termination of translesion DNA synthesis R-HSA-5656169 1.499444e-02 1.824 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.499444e-02 1.824 0 0
RSV-host interactions R-HSA-9833110 1.550647e-02 1.809 0 0
Metabolism of proteins R-HSA-392499 1.567377e-02 1.805 1 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.608032e-02 1.794 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.608032e-02 1.794 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 1.643666e-02 1.784 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.643666e-02 1.784 0 0
Basigin interactions R-HSA-210991 1.643666e-02 1.784 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 1.643666e-02 1.784 0 0
Nucleotide Excision Repair R-HSA-5696398 1.650472e-02 1.782 0 0
MAP kinase activation R-HSA-450294 1.727035e-02 1.763 1 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 1.857170e-02 1.731 0 0
Synthesis of DNA R-HSA-69239 1.864674e-02 1.729 0 0
Signaling by PDGF R-HSA-186797 1.874186e-02 1.727 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.898465e-02 1.722 0 0
Assembly Of The HIV Virion R-HSA-175474 1.898465e-02 1.722 0 0
Budding and maturation of HIV virion R-HSA-162588 1.909938e-02 1.719 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 1.909938e-02 1.719 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 1.909938e-02 1.719 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 1.926557e-02 1.715 0 0
SOS-mediated signalling R-HSA-112412 1.926557e-02 1.715 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.926557e-02 1.715 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.935988e-02 1.713 0 0
Signaling by FGFR4 in disease R-HSA-5655291 1.935988e-02 1.713 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.988173e-02 1.702 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 2.037726e-02 1.691 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.056032e-02 1.687 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.069041e-02 1.684 0 0
Generic Transcription Pathway R-HSA-212436 2.120505e-02 1.674 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.141386e-02 1.669 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 2.158687e-02 1.666 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 2.195422e-02 1.658 1 0
HIV Life Cycle R-HSA-162587 2.215400e-02 1.655 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.302407e-02 1.638 0 0
DCC mediated attractive signaling R-HSA-418885 2.302407e-02 1.638 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 2.302407e-02 1.638 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 2.391075e-02 1.621 0 0
G-protein beta:gamma signalling R-HSA-397795 2.391075e-02 1.621 0 0
Ca-dependent events R-HSA-111996 2.411188e-02 1.618 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 2.462321e-02 1.609 0 0
Type I hemidesmosome assembly R-HSA-446107 2.462321e-02 1.609 0 0
ABC-family proteins mediated transport R-HSA-382556 2.482902e-02 1.605 0 0
ABC transporter disorders R-HSA-5619084 2.516145e-02 1.599 0 0
Regulation of TP53 Activity R-HSA-5633007 2.546732e-02 1.594 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 2.633336e-02 1.579 0 0
Striated Muscle Contraction R-HSA-390522 2.659535e-02 1.575 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.708226e-02 1.567 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 2.708226e-02 1.567 0 0
Signaling by NOTCH3 R-HSA-9012852 2.744586e-02 1.562 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.813849e-02 1.551 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.813849e-02 1.551 0 0
Neurodegenerative Diseases R-HSA-8863678 2.813849e-02 1.551 0 0
RAF activation R-HSA-5673000 2.947252e-02 1.531 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 2.947252e-02 1.531 0 0
Mitophagy R-HSA-5205647 2.947252e-02 1.531 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 3.070085e-02 1.513 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 3.070085e-02 1.513 0 0
Calcineurin activates NFAT R-HSA-2025928 3.070085e-02 1.513 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.070085e-02 1.513 0 0
Somitogenesis R-HSA-9824272 3.155472e-02 1.501 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.175588e-02 1.498 0 0
Axonal growth stimulation R-HSA-209563 3.252270e-02 1.488 0 0
MET interacts with TNS proteins R-HSA-8875513 3.252270e-02 1.488 0 0
MET activates PTPN11 R-HSA-8865999 3.252270e-02 1.488 0 0
Signalling to ERKs R-HSA-187687 3.254669e-02 1.487 0 0
Oncogene Induced Senescence R-HSA-2559585 3.254669e-02 1.487 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 3.311794e-02 1.480 0 0
Interleukin-17 signaling R-HSA-448424 3.393118e-02 1.469 1 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 3.488327e-02 1.457 1 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 3.556492e-02 1.449 0 0
Parasitic Infection Pathways R-HSA-9824443 3.575568e-02 1.447 0 0
Leishmania infection R-HSA-9658195 3.575568e-02 1.447 0 0
RET signaling R-HSA-8853659 3.582180e-02 1.446 0 0
Glucose metabolism R-HSA-70326 3.612651e-02 1.442 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.629335e-02 1.440 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 3.640638e-02 1.439 0 0
Uptake and function of anthrax toxins R-HSA-5210891 3.640638e-02 1.439 0 0
Glycogen storage diseases R-HSA-3229121 3.640638e-02 1.439 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 3.705485e-02 1.431 0 0
Drug resistance of FLT3 mutants R-HSA-9702506 5.441741e-02 1.264 0 0
Drug resistance of ALK mutants R-HSA-9700649 5.441741e-02 1.264 0 0
Drug resistance of KIT mutants R-HSA-9669937 5.441741e-02 1.264 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 5.441741e-02 1.264 0 0
KIT mutants bind TKIs R-HSA-9669921 5.441741e-02 1.264 0 0
PDGFR mutants bind TKIs R-HSA-9674428 5.441741e-02 1.264 0 0
FLT3 mutants bind TKIs R-HSA-9702509 5.441741e-02 1.264 0 0
tandutinib-resistant FLT3 mutants R-HSA-9702636 5.441741e-02 1.264 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 5.441741e-02 1.264 0 0
gilteritinib-resistant FLT3 mutants R-HSA-9702590 5.441741e-02 1.264 0 0
midostaurin-resistant FLT3 mutants R-HSA-9702600 5.441741e-02 1.264 0 0
quizartinib-resistant FLT3 mutants R-HSA-9702620 5.441741e-02 1.264 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 5.441741e-02 1.264 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 5.441741e-02 1.264 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 5.441741e-02 1.264 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 5.441741e-02 1.264 0 0
ponatinib-resistant FLT3 mutants R-HSA-9702614 5.441741e-02 1.264 0 0
ASP-3026-resistant ALK mutants R-HSA-9717264 5.441741e-02 1.264 0 0
KW2449-resistant FLT3 mutants R-HSA-9702569 5.441741e-02 1.264 0 0
NVP-TAE684-resistant ALK mutants R-HSA-9717301 5.441741e-02 1.264 0 0
lestaurtinib-resistant FLT3 mutants R-HSA-9702596 5.441741e-02 1.264 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 5.441741e-02 1.264 0 0
alectinib-resistant ALK mutants R-HSA-9717316 5.441741e-02 1.264 0 0
sunitinib-resistant FLT3 mutants R-HSA-9702632 5.441741e-02 1.264 0 0
tamatinib-resistant FLT3 mutants R-HSA-9703009 5.441741e-02 1.264 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 5.441741e-02 1.264 0 0
pexidartinib-resistant FLT3 mutants R-HSA-9702605 5.441741e-02 1.264 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 5.441741e-02 1.264 0 0
brigatinib-resistant ALK mutants R-HSA-9717319 5.441741e-02 1.264 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 5.441741e-02 1.264 0 0
crizotinib-resistant ALK mutants R-HSA-9717326 5.441741e-02 1.264 0 0
ceritinib-resistant ALK mutants R-HSA-9717323 5.441741e-02 1.264 0 0
crenolanib-resistant FLT3 mutants R-HSA-9702581 5.441741e-02 1.264 0 0
linifanib-resistant FLT3 mutants R-HSA-9702998 5.441741e-02 1.264 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 5.441741e-02 1.264 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 5.441741e-02 1.264 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 5.441741e-02 1.264 0 0
sorafenib-resistant FLT3 mutants R-HSA-9702624 5.441741e-02 1.264 0 0
semaxanib-resistant FLT3 mutants R-HSA-9702577 5.441741e-02 1.264 0 0
lorlatinib-resistant ALK mutants R-HSA-9717329 5.441741e-02 1.264 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.516513e-02 1.345 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 5.929644e-02 1.227 0 0
IRS activation R-HSA-74713 5.929644e-02 1.227 0 0
Activation of AKT2 R-HSA-165158 5.929644e-02 1.227 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.929644e-02 1.227 0 0
NTRK2 activates RAC1 R-HSA-9032759 5.929644e-02 1.227 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 3.749145e-02 1.426 0 0
PI3K/AKT activation R-HSA-198203 3.749145e-02 1.426 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 3.749145e-02 1.426 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 5.315394e-02 1.274 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 5.315394e-02 1.274 0 0
MET activates RAS signaling R-HSA-8851805 6.198500e-02 1.208 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 6.198500e-02 1.208 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 6.198500e-02 1.208 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 6.198500e-02 1.208 0 0
GRB2 events in EGFR signaling R-HSA-179812 6.198500e-02 1.208 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 6.198500e-02 1.208 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 7.144896e-02 1.146 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 7.144896e-02 1.146 0 0
GAB1 signalosome R-HSA-180292 4.167959e-02 1.380 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 5.345076e-02 1.272 0 0
Interaction between L1 and Ankyrins R-HSA-445095 3.969011e-02 1.401 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 6.683559e-02 1.175 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 7.411937e-02 1.130 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 5.099396e-02 1.292 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 7.116821e-02 1.148 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 6.303666e-02 1.200 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 5.590677e-02 1.253 0 0
IGF1R signaling cascade R-HSA-2428924 5.244803e-02 1.280 0 0
Insulin receptor signalling cascade R-HSA-74751 5.244803e-02 1.280 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 4.291013e-02 1.367 0 0
Integrin signaling R-HSA-354192 7.034391e-02 1.153 0 0
Signal attenuation R-HSA-74749 3.749145e-02 1.426 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 4.167959e-02 1.380 0 0
Regulation of CDH11 function R-HSA-9762292 3.749145e-02 1.426 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 5.099396e-02 1.292 0 0
PLC beta mediated events R-HSA-112043 4.291013e-02 1.367 0 0
Signaling by ALK R-HSA-201556 4.688517e-02 1.329 0 0
FCERI mediated NF-kB activation R-HSA-2871837 4.275075e-02 1.369 1 1
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 4.736156e-02 1.325 0 0
RAS processing R-HSA-9648002 4.688517e-02 1.329 0 0
Signalling to RAS R-HSA-167044 5.994381e-02 1.222 0 0
Signaling by FGFR1 in disease R-HSA-5655302 5.985283e-02 1.223 0 0
G-protein mediated events R-HSA-112040 6.325061e-02 1.199 0 0
Post-translational protein modification R-HSA-597592 3.845655e-02 1.415 1 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 4.736156e-02 1.325 0 0
Attachment and Entry R-HSA-9694614 6.683559e-02 1.175 0 0
MTF1 activates gene expression R-HSA-5660489 4.516513e-02 1.345 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.516513e-02 1.345 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.929644e-02 1.227 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.064017e-02 1.296 1 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.523816e-02 1.344 1 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 4.625453e-02 1.335 1 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 4.625453e-02 1.335 1 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 4.625453e-02 1.335 1 0
MyD88-independent TLR4 cascade R-HSA-166166 4.523816e-02 1.344 1 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 7.034391e-02 1.153 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 7.471755e-02 1.127 0 0
Chromatin organization R-HSA-4839726 5.313001e-02 1.275 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 7.144896e-02 1.146 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 4.409434e-02 1.356 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 6.683559e-02 1.175 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.930134e-02 1.406 0 0
Other interleukin signaling R-HSA-449836 4.736156e-02 1.325 0 0
Interleukin-2 family signaling R-HSA-451927 5.099396e-02 1.292 0 0
Neuronal System R-HSA-112316 6.159026e-02 1.210 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 4.736156e-02 1.325 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 6.453061e-02 1.190 0 0
Potential therapeutics for SARS R-HSA-9679191 5.494264e-02 1.260 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 4.426286e-02 1.354 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 6.713739e-02 1.173 0 0
ER-Phagosome pathway R-HSA-1236974 5.236706e-02 1.281 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 4.385141e-02 1.358 0 0
Regulated Necrosis R-HSA-5218859 6.713739e-02 1.173 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 3.969011e-02 1.401 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 6.683559e-02 1.175 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 5.994381e-02 1.222 0 0
Formation of paraxial mesoderm R-HSA-9793380 4.291013e-02 1.367 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 3.749145e-02 1.426 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 7.367431e-02 1.133 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 6.683559e-02 1.175 0 0
Interleukin-37 signaling R-HSA-9008059 5.374753e-02 1.270 0 0
Response of Mtb to phagocytosis R-HSA-9637690 6.957096e-02 1.158 0 0
Unfolded Protein Response (UPR) R-HSA-381119 6.007317e-02 1.221 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 5.828402e-02 1.234 0 0
Proteasome assembly R-HSA-9907900 7.475201e-02 1.126 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 7.503389e-02 1.125 1 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 7.503389e-02 1.125 1 0
IRS-mediated signalling R-HSA-112399 7.595458e-02 1.119 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 7.643567e-02 1.117 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 7.643567e-02 1.117 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.871920e-02 1.104 1 0
Signaling by TGFB family members R-HSA-9006936 8.021735e-02 1.096 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 8.151678e-02 1.089 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 8.178692e-02 1.087 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 8.178692e-02 1.087 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 8.178692e-02 1.087 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 8.223676e-02 1.085 1 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 8.280286e-02 1.082 0 0
Nuclear import of Rev protein R-HSA-180746 8.280286e-02 1.082 0 0
Signaling by NOTCH2 R-HSA-1980145 8.280286e-02 1.082 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 8.492978e-02 1.071 1 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 8.492978e-02 1.071 1 0
snRNP Assembly R-HSA-191859 8.574800e-02 1.067 0 0
Metabolism of non-coding RNA R-HSA-194441 8.574800e-02 1.067 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 8.575239e-02 1.067 0 0
Amplification of signal from the kinetochores R-HSA-141424 8.575239e-02 1.067 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 8.575239e-02 1.067 0 0
Regulation of pyruvate metabolism R-HSA-9861718 8.575341e-02 1.067 0 0
Signaling by NTRKs R-HSA-166520 8.820466e-02 1.055 0 0
Deadenylation of mRNA R-HSA-429947 8.982868e-02 1.047 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 8.982868e-02 1.047 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 9.090211e-02 1.041 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 9.090211e-02 1.041 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 9.090211e-02 1.041 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 9.090211e-02 1.041 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 9.090211e-02 1.041 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 9.124657e-02 1.040 0 0
Signaling by LTK in cancer R-HSA-9842640 9.124657e-02 1.040 0 0
STAT5 Activation R-HSA-9645135 9.124657e-02 1.040 0 0
Erythropoietin activates STAT5 R-HSA-9027283 9.124657e-02 1.040 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 9.124657e-02 1.040 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 9.124657e-02 1.040 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.157052e-02 1.038 1 1
SHC1 events in EGFR signaling R-HSA-180336 9.215716e-02 1.035 0 0
p38MAPK events R-HSA-171007 9.215716e-02 1.035 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 9.215716e-02 1.035 0 0
Signaling by FGFR in disease R-HSA-1226099 9.348686e-02 1.029 0 0
MITF-M-dependent gene expression R-HSA-9856651 9.468452e-02 1.024 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 9.726863e-02 1.012 1 0
Gluconeogenesis R-HSA-70263 9.759567e-02 1.011 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 1.033370e-01 0.986 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.038262e-01 0.984 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.058767e-01 0.975 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.058767e-01 0.975 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 1.058767e-01 0.975 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.058767e-01 0.975 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.058767e-01 0.975 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.058767e-01 0.975 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.058767e-01 0.975 0 0
Inhibition of PKR R-HSA-169131 1.058767e-01 0.975 0 0
Metalloprotease DUBs R-HSA-5689901 1.069905e-01 0.971 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.069905e-01 0.971 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.069905e-01 0.971 0 0
Suppression of phagosomal maturation R-HSA-9637687 1.069905e-01 0.971 0 0
Disinhibition of SNARE formation R-HSA-114516 1.087176e-01 0.964 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.087176e-01 0.964 0 0
CHL1 interactions R-HSA-447041 1.087176e-01 0.964 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 1.095501e-01 0.960 1 0
PI3K Cascade R-HSA-109704 1.102589e-01 0.958 0 0
Signaling by FGFR2 in disease R-HSA-5655253 1.102589e-01 0.958 0 0
Azathioprine ADME R-HSA-9748787 1.102589e-01 0.958 0 0
MET promotes cell motility R-HSA-8875878 1.109398e-01 0.955 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.109398e-01 0.955 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.110426e-01 0.955 0 0
G alpha (12/13) signalling events R-HSA-416482 1.139124e-01 0.943 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 1.150220e-01 0.939 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 1.150220e-01 0.939 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 1.150220e-01 0.939 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.150220e-01 0.939 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 1.160858e-01 0.935 0 0
Signaling by FGFR3 in disease R-HSA-5655332 1.160858e-01 0.935 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 1.160858e-01 0.935 0 0
IRE1alpha activates chaperones R-HSA-381070 1.182418e-01 0.927 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.186138e-01 0.926 0 0
Plasma lipoprotein clearance R-HSA-8964043 1.186138e-01 0.926 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 1.186138e-01 0.926 0 0
Sensory processing of sound R-HSA-9659379 1.193675e-01 0.923 0 0
HCMV Late Events R-HSA-9610379 1.196260e-01 0.922 0 0
Signaling by Insulin receptor R-HSA-74752 1.233662e-01 0.909 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.237167e-01 0.908 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.249591e-01 0.903 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 1.269793e-01 0.896 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 1.269793e-01 0.896 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 1.269793e-01 0.896 0 0
MET receptor recycling R-HSA-8875656 1.269793e-01 0.896 0 0
Formation of annular gap junctions R-HSA-196025 1.269793e-01 0.896 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 1.269793e-01 0.896 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 1.269793e-01 0.896 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 1.269793e-01 0.896 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 1.269793e-01 0.896 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 1.269793e-01 0.896 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.271767e-01 0.896 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 1.271767e-01 0.896 0 0
Chromatin modifying enzymes R-HSA-3247509 1.276868e-01 0.894 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.307336e-01 0.884 0 0
Circadian clock R-HSA-9909396 1.322619e-01 0.879 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 1.352365e-01 0.869 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 1.352365e-01 0.869 0 0
Toll-like Receptor Cascades R-HSA-168898 1.366104e-01 0.865 1 0
Cell surface interactions at the vascular wall R-HSA-202733 1.377551e-01 0.861 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 1.394389e-01 0.856 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.397655e-01 0.855 0 0
Tie2 Signaling R-HSA-210993 1.397655e-01 0.855 0 0
Antigen processing-Cross presentation R-HSA-1236975 1.409570e-01 0.851 0 0
Translation of Structural Proteins R-HSA-9683701 1.430626e-01 0.844 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 1.452624e-01 0.838 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.458943e-01 0.836 0 0
ARMS-mediated activation R-HSA-170984 1.458943e-01 0.836 0 0
Gap junction degradation R-HSA-190873 1.458943e-01 0.836 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.458943e-01 0.836 0 0
Hypusine synthesis from eIF5A-lysine R-HSA-204626 1.458943e-01 0.836 0 0
ALK mutants bind TKIs R-HSA-9700645 1.458943e-01 0.836 0 0
p75NTR regulates axonogenesis R-HSA-193697 1.458943e-01 0.836 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 1.458943e-01 0.836 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.458943e-01 0.836 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 1.458943e-01 0.836 0 0
Rap1 signalling R-HSA-392517 1.527523e-01 0.816 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.527523e-01 0.816 0 0
NRAGE signals death through JNK R-HSA-193648 1.528815e-01 0.816 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.528815e-01 0.816 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 1.528815e-01 0.816 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.528815e-01 0.816 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 1.545384e-01 0.811 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 1.545384e-01 0.811 0 0
Defective HK1 causes hexokinase deficiency (HK deficiency) R-HSA-5619056 1.545384e-01 0.811 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 1.545384e-01 0.811 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 1.545384e-01 0.811 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 1.545384e-01 0.811 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 1.545384e-01 0.811 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 1.545384e-01 0.811 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 1.545384e-01 0.811 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 1.545384e-01 0.811 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 1.545384e-01 0.811 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 1.545384e-01 0.811 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 1.545384e-01 0.811 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 1.545384e-01 0.811 0 0
Trafficking of AMPA receptors R-HSA-399719 1.555679e-01 0.808 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.606126e-01 0.794 0 0
FCERI mediated MAPK activation R-HSA-2871796 1.624866e-01 0.789 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 1.653375e-01 0.782 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.661369e-01 0.780 0 0
G0 and Early G1 R-HSA-1538133 1.661369e-01 0.780 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.675863e-01 0.776 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.677439e-01 0.775 0 0
FOXO-mediated transcription R-HSA-9614085 1.684598e-01 0.774 0 0
Netrin-1 signaling R-HSA-373752 1.694820e-01 0.771 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 1.723806e-01 0.764 0 0
Pyruvate metabolism R-HSA-70268 1.743466e-01 0.759 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.745814e-01 0.758 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.769532e-01 0.752 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.769532e-01 0.752 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.769532e-01 0.752 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.769532e-01 0.752 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 1.769532e-01 0.752 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.786852e-01 0.748 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.797767e-01 0.745 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.851956e-01 0.732 0 0
Bicarbonate transporters R-HSA-425381 1.851956e-01 0.732 0 0
Interleukin-2 signaling R-HSA-9020558 1.851956e-01 0.732 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 1.851956e-01 0.732 0 0
Dissolution of Fibrin Clot R-HSA-75205 1.851956e-01 0.732 0 0
Iron uptake and transport R-HSA-917937 1.873646e-01 0.727 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 1.879999e-01 0.726 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 1.879999e-01 0.726 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.880710e-01 0.726 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.880710e-01 0.726 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.937434e-01 0.713 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.937434e-01 0.713 0 0
Signaling by NOTCH1 R-HSA-1980143 1.949303e-01 0.710 0 0
eNOS activation R-HSA-203615 1.992604e-01 0.701 0 0
Calnexin/calreticulin cycle R-HSA-901042 1.992604e-01 0.701 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 2.005546e-01 0.698 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 2.005546e-01 0.698 0 0
Signaling by RAS GAP mutants R-HSA-9753510 2.005546e-01 0.698 0 0
Defective AHCY causes HMAHCHD R-HSA-5578997 2.005546e-01 0.698 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 2.005546e-01 0.698 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 2.005546e-01 0.698 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 2.005546e-01 0.698 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 2.005546e-01 0.698 0 0
Diseases of cellular response to stress R-HSA-9675132 2.005546e-01 0.698 0 0
Diseases of Cellular Senescence R-HSA-9630747 2.005546e-01 0.698 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 2.005546e-01 0.698 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 2.005546e-01 0.698 0 0
NCAM signaling for neurite out-growth R-HSA-375165 2.016224e-01 0.695 0 0
Translation of Structural Proteins R-HSA-9694635 2.026151e-01 0.693 0 0
Activation of RAC1 R-HSA-428540 2.053660e-01 0.687 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 2.053660e-01 0.687 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.053660e-01 0.687 0 0
Integration of provirus R-HSA-162592 2.053660e-01 0.687 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 2.079671e-01 0.682 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 2.079671e-01 0.682 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 2.102512e-01 0.677 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 2.107177e-01 0.676 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 2.107177e-01 0.676 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 2.172254e-01 0.663 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 2.224140e-01 0.653 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 2.224140e-01 0.653 0 0
Growth hormone receptor signaling R-HSA-982772 2.224140e-01 0.653 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.257562e-01 0.646 0 0
Scavenging by Class F Receptors R-HSA-3000484 2.257562e-01 0.646 0 0
Regulation of IFNG signaling R-HSA-877312 2.257562e-01 0.646 0 0
Signaling by LTK R-HSA-9842663 2.257562e-01 0.646 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 2.257562e-01 0.646 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.341553e-01 0.630 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 2.370516e-01 0.625 0 0
PLC-gamma1 signalling R-HSA-167021 2.440688e-01 0.612 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 2.440688e-01 0.612 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 2.440688e-01 0.612 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 2.440688e-01 0.612 0 0
MET activates STAT3 R-HSA-8875791 2.440688e-01 0.612 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.459663e-01 0.609 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 2.461021e-01 0.609 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 2.462824e-01 0.609 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.462824e-01 0.609 0 0
Interleukin-6 signaling R-HSA-1059683 2.462824e-01 0.609 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 2.462824e-01 0.609 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.462824e-01 0.609 0 0
Neurexins and neuroligins R-HSA-6794361 2.476628e-01 0.606 0 0
Tight junction interactions R-HSA-420029 2.518482e-01 0.599 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 2.518482e-01 0.599 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 2.518482e-01 0.599 0 0
Protein localization R-HSA-9609507 2.544580e-01 0.594 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 2.581787e-01 0.588 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 2.581787e-01 0.588 0 0
MET activates PTK2 signaling R-HSA-8874081 2.667735e-01 0.574 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.667735e-01 0.574 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 2.668697e-01 0.574 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 2.793093e-01 0.554 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.817980e-01 0.550 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.817980e-01 0.550 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 2.817980e-01 0.550 0 0
Insulin processing R-HSA-264876 2.817980e-01 0.550 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 2.852171e-01 0.545 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 2.852171e-01 0.545 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 2.852171e-01 0.545 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 2.852171e-01 0.545 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.852171e-01 0.545 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.852171e-01 0.545 0 0
Regulation of gap junction activity R-HSA-191650 2.852171e-01 0.545 0 0
MDK and PTN in ALK signaling R-HSA-9851151 2.852171e-01 0.545 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.852171e-01 0.545 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.852171e-01 0.545 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 2.852171e-01 0.545 0 0
NADE modulates death signalling R-HSA-205025 2.852171e-01 0.545 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 2.874508e-01 0.541 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.874508e-01 0.541 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 2.874508e-01 0.541 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.874508e-01 0.541 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 2.874508e-01 0.541 0 0
Ion homeostasis R-HSA-5578775 2.897626e-01 0.538 0 0
HIV elongation arrest and recovery R-HSA-167287 2.968938e-01 0.527 0 0
Pausing and recovery of HIV elongation R-HSA-167290 2.968938e-01 0.527 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 2.968938e-01 0.527 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 2.968938e-01 0.527 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.074618e-01 0.512 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 3.079652e-01 0.511 0 0
Prolonged ERK activation events R-HSA-169893 3.079652e-01 0.511 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 3.079652e-01 0.511 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 3.079652e-01 0.511 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 3.112789e-01 0.507 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.120048e-01 0.506 0 0
mRNA Capping R-HSA-72086 3.120342e-01 0.506 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.120342e-01 0.506 0 0
Rab regulation of trafficking R-HSA-9007101 3.144288e-01 0.502 0 0
Opioid Signalling R-HSA-111885 3.173954e-01 0.498 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.221188e-01 0.492 0 0
Peroxisomal protein import R-HSA-9033241 3.221188e-01 0.492 0 0
G2 Phase R-HSA-68911 3.241278e-01 0.489 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 3.241278e-01 0.489 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 3.241278e-01 0.489 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 3.241278e-01 0.489 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 3.241278e-01 0.489 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.241278e-01 0.489 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 3.241278e-01 0.489 0 0
Muscarinic acetylcholine receptors R-HSA-390648 3.241278e-01 0.489 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 3.241278e-01 0.489 0 0
Reelin signalling pathway R-HSA-8866376 3.241278e-01 0.489 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 3.241278e-01 0.489 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 3.241278e-01 0.489 0 0
Co-inhibition by BTLA R-HSA-9927353 3.241278e-01 0.489 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 3.241278e-01 0.489 0 0
Extracellular matrix organization R-HSA-1474244 3.248385e-01 0.488 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.271937e-01 0.485 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.271937e-01 0.485 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 3.271937e-01 0.485 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 3.283596e-01 0.484 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 3.283596e-01 0.484 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 3.283596e-01 0.484 0 0
Response to metal ions R-HSA-5660526 3.283596e-01 0.484 0 0
Disorders of transmembrane transporters R-HSA-5619115 3.292025e-01 0.483 0 0
RMTs methylate histone arginines R-HSA-3214858 3.324732e-01 0.478 0 0
Metabolism of polyamines R-HSA-351202 3.330004e-01 0.478 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 3.423483e-01 0.466 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 3.423483e-01 0.466 0 0
Viral Messenger RNA Synthesis R-HSA-168325 3.439140e-01 0.464 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 3.450200e-01 0.462 0 0
Fanconi Anemia Pathway R-HSA-6783310 3.450200e-01 0.462 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 3.466219e-01 0.460 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 3.466219e-01 0.460 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 3.485861e-01 0.458 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 3.509847e-01 0.455 0 0
Integration of energy metabolism R-HSA-163685 3.546483e-01 0.450 0 0
tRNA processing in the nucleus R-HSA-6784531 3.548505e-01 0.450 0 0
HS-GAG degradation R-HSA-2024096 3.574751e-01 0.447 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 3.575758e-01 0.447 0 0
Plus-strand DNA synthesis R-HSA-164525 3.609226e-01 0.443 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 3.609226e-01 0.443 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 3.609226e-01 0.443 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 3.609226e-01 0.443 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 3.609226e-01 0.443 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 3.609226e-01 0.443 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 3.609226e-01 0.443 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 3.609226e-01 0.443 0 0
PKB-mediated events R-HSA-109703 3.609226e-01 0.443 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 3.609226e-01 0.443 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 3.609226e-01 0.443 0 0
Cam-PDE 1 activation R-HSA-111957 3.609226e-01 0.443 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 3.609226e-01 0.443 0 0
PDE3B signalling R-HSA-165160 3.609226e-01 0.443 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 3.609226e-01 0.443 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 3.609226e-01 0.443 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.609226e-01 0.443 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 3.609226e-01 0.443 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 3.609226e-01 0.443 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 3.686026e-01 0.433 0 0
Platelet sensitization by LDL R-HSA-432142 3.686026e-01 0.433 0 0
PKA activation R-HSA-163615 3.686026e-01 0.433 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 3.686026e-01 0.433 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 3.686026e-01 0.433 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.725526e-01 0.429 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.725526e-01 0.429 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 3.725526e-01 0.429 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.725526e-01 0.429 0 0
Neddylation R-HSA-8951664 3.746906e-01 0.426 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 3.875608e-01 0.412 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.875608e-01 0.412 0 0
Effects of PIP2 hydrolysis R-HSA-114508 3.875608e-01 0.412 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 3.883723e-01 0.411 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 3.883723e-01 0.411 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 3.883723e-01 0.411 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 3.883723e-01 0.411 0 0
The NLRP3 inflammasome R-HSA-844456 3.883723e-01 0.411 0 0
Maturation of nucleoprotein R-HSA-9694631 3.883723e-01 0.411 0 0
Leishmania parasite growth and survival R-HSA-9664433 3.898799e-01 0.409 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 3.898799e-01 0.409 0 0
Chylomicron clearance R-HSA-8964026 3.957163e-01 0.403 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 3.957163e-01 0.403 0 0
Uncoating of the HIV Virion R-HSA-162585 3.957163e-01 0.403 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 3.957163e-01 0.403 0 0
MET Receptor Activation R-HSA-6806942 3.957163e-01 0.403 0 0
CREB phosphorylation R-HSA-199920 3.957163e-01 0.403 0 0
VLDL assembly R-HSA-8866423 3.957163e-01 0.403 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 4.024807e-01 0.395 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 4.078626e-01 0.389 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 4.078626e-01 0.389 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.078626e-01 0.389 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 4.078626e-01 0.389 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 4.078626e-01 0.389 0 0
Creatine metabolism R-HSA-71288 4.078626e-01 0.389 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 4.172947e-01 0.380 0 0
PERK regulates gene expression R-HSA-381042 4.172947e-01 0.380 0 0
Protein-protein interactions at synapses R-HSA-6794362 4.198127e-01 0.377 0 0
The phototransduction cascade R-HSA-2514856 4.200458e-01 0.377 0 0
Early Phase of HIV Life Cycle R-HSA-162594 4.270454e-01 0.370 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 4.270454e-01 0.370 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 4.270454e-01 0.370 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 4.270454e-01 0.370 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 4.270454e-01 0.370 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 4.286178e-01 0.368 0 0
DAG1 core M1 glycosylations R-HSA-8932506 4.286178e-01 0.368 0 0
Recycling of eIF2:GDP R-HSA-72731 4.286178e-01 0.368 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 4.286178e-01 0.368 0 0
PTK6 Expression R-HSA-8849473 4.286178e-01 0.368 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 4.286178e-01 0.368 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 4.286178e-01 0.368 0 0
LDL remodeling R-HSA-8964041 4.286178e-01 0.368 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 4.286178e-01 0.368 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 4.286178e-01 0.368 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 4.286178e-01 0.368 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 4.286178e-01 0.368 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 4.286178e-01 0.368 0 0
HS-GAG biosynthesis R-HSA-2022928 4.319864e-01 0.365 0 0
RUNX2 regulates bone development R-HSA-8941326 4.319864e-01 0.365 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 4.458964e-01 0.351 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 4.458964e-01 0.351 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 4.458964e-01 0.351 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 4.458964e-01 0.351 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 4.458964e-01 0.351 0 0
Ribavirin ADME R-HSA-9755088 4.458964e-01 0.351 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 4.465407e-01 0.350 0 0
Retinoid metabolism and transport R-HSA-975634 4.528895e-01 0.344 0 0
Gastrulation R-HSA-9758941 4.580573e-01 0.339 0 0
Reverse Transcription of HIV RNA R-HSA-162589 4.597297e-01 0.337 0 0
Minus-strand DNA synthesis R-HSA-164516 4.597297e-01 0.337 0 0
DAG1 core M2 glycosylations R-HSA-8932504 4.597297e-01 0.337 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 4.597297e-01 0.337 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 4.597297e-01 0.337 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 4.597297e-01 0.337 0 0
Co-stimulation by ICOS R-HSA-9927354 4.597297e-01 0.337 0 0
Activation of RAS in B cells R-HSA-1169092 4.597297e-01 0.337 0 0
Interleukin-9 signaling R-HSA-8985947 4.597297e-01 0.337 0 0
Adrenoceptors R-HSA-390696 4.597297e-01 0.337 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.597297e-01 0.337 0 0
RSK activation R-HSA-444257 4.597297e-01 0.337 0 0
Sodium/Proton exchangers R-HSA-425986 4.597297e-01 0.337 0 0
Interleukin-23 signaling R-HSA-9020933 4.597297e-01 0.337 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 4.609436e-01 0.336 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 4.635957e-01 0.334 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 4.643950e-01 0.333 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 4.643950e-01 0.333 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 4.643950e-01 0.333 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 4.643950e-01 0.333 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 4.643950e-01 0.333 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 4.643950e-01 0.333 0 0
G alpha (z) signalling events R-HSA-418597 4.689724e-01 0.329 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 4.751822e-01 0.323 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 4.751822e-01 0.323 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 4.800722e-01 0.319 0 0
Interleukin receptor SHC signaling R-HSA-912526 4.825237e-01 0.316 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 4.825237e-01 0.316 0 0
Lipophagy R-HSA-9613354 4.891493e-01 0.311 0 0
Interleukin-21 signaling R-HSA-9020958 4.891493e-01 0.311 0 0
WNT mediated activation of DVL R-HSA-201688 4.891493e-01 0.311 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.891493e-01 0.311 0 0
Regulated proteolysis of p75NTR R-HSA-193692 4.891493e-01 0.311 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 4.891493e-01 0.311 0 0
Cellular response to mitochondrial stress R-HSA-9840373 4.891493e-01 0.311 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 4.891493e-01 0.311 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 4.892446e-01 0.310 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.892446e-01 0.310 0 0
HIV Transcription Elongation R-HSA-167169 4.892446e-01 0.310 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.892446e-01 0.310 0 0
Diseases of Immune System R-HSA-5260271 4.892446e-01 0.310 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 4.892446e-01 0.310 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 4.892446e-01 0.310 0 0
Dectin-2 family R-HSA-5621480 4.928715e-01 0.307 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 5.002678e-01 0.301 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 5.002678e-01 0.301 0 0
Mitochondrial RNA degradation R-HSA-9836573 5.002678e-01 0.301 0 0
Plasma lipoprotein assembly R-HSA-8963898 5.002678e-01 0.301 0 0
Interleukin-6 family signaling R-HSA-6783589 5.002678e-01 0.301 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 5.031203e-01 0.298 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.031203e-01 0.298 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 5.031203e-01 0.298 0 0
FCGR activation R-HSA-2029481 5.159649e-01 0.287 0 0
Binding and entry of HIV virion R-HSA-173107 5.169687e-01 0.287 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 5.169687e-01 0.287 0 0
Formation of apoptosome R-HSA-111458 5.169687e-01 0.287 0 0
Regulation of the apoptosome activity R-HSA-9627069 5.169687e-01 0.287 0 0
2-LTR circle formation R-HSA-164843 5.169687e-01 0.287 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 5.169687e-01 0.287 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 5.169687e-01 0.287 0 0
CASP4 inflammasome assembly R-HSA-9948001 5.169687e-01 0.287 0 0
Interleukin-27 signaling R-HSA-9020956 5.169687e-01 0.287 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 5.169687e-01 0.287 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 5.169687e-01 0.287 0 0
Receptor Mediated Mitophagy R-HSA-8934903 5.169687e-01 0.287 0 0
Signaling by Leptin R-HSA-2586552 5.169687e-01 0.287 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 5.176156e-01 0.286 0 0
Laminin interactions R-HSA-3000157 5.176156e-01 0.286 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 5.176156e-01 0.286 0 0
Interleukin-7 signaling R-HSA-1266695 5.176156e-01 0.286 0 0
RAB geranylgeranylation R-HSA-8873719 5.278359e-01 0.278 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 5.302735e-01 0.276 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 5.345576e-01 0.272 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 5.345576e-01 0.272 0 0
Inositol phosphate metabolism R-HSA-1483249 5.415686e-01 0.266 0 0
DAG1 core M3 glycosylations R-HSA-8932505 5.432746e-01 0.265 0 0
Ionotropic activity of kainate receptors R-HSA-451306 5.432746e-01 0.265 0 0
vRNA Synthesis R-HSA-192814 5.432746e-01 0.265 0 0
vRNP Assembly R-HSA-192905 5.432746e-01 0.265 0 0
Chylomicron assembly R-HSA-8963888 5.432746e-01 0.265 0 0
LGI-ADAM interactions R-HSA-5682910 5.432746e-01 0.265 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 5.432746e-01 0.265 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 5.510866e-01 0.259 0 0
Cristae formation R-HSA-8949613 5.510866e-01 0.259 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 5.510866e-01 0.259 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 5.564257e-01 0.255 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 5.671972e-01 0.246 0 0
Formation of the Early Elongation Complex R-HSA-113418 5.671972e-01 0.246 0 0
Insulin receptor recycling R-HSA-77387 5.671972e-01 0.246 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 5.671972e-01 0.246 0 0
Inflammasomes R-HSA-622312 5.671972e-01 0.246 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 5.681495e-01 0.246 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 5.681495e-01 0.246 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 5.681495e-01 0.246 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.681495e-01 0.246 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 5.681495e-01 0.246 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 5.681495e-01 0.246 0 0
Plasmalogen biosynthesis R-HSA-75896 5.681495e-01 0.246 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 5.681495e-01 0.246 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 5.681495e-01 0.246 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.681495e-01 0.246 0 0
Sodium/Calcium exchangers R-HSA-425561 5.681495e-01 0.246 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 5.681495e-01 0.246 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 5.693906e-01 0.245 0 0
Post-translational protein phosphorylation R-HSA-8957275 5.706461e-01 0.244 0 0
Ion transport by P-type ATPases R-HSA-936837 5.725378e-01 0.242 0 0
Visual phototransduction R-HSA-2187338 5.753279e-01 0.240 0 0
Signaling by TGFBR3 R-HSA-9839373 5.819744e-01 0.235 0 0
DARPP-32 events R-HSA-180024 5.828861e-01 0.234 0 0
Platelet calcium homeostasis R-HSA-418360 5.828861e-01 0.234 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 5.828861e-01 0.234 0 0
Regulation of gene expression in beta cells R-HSA-210745 5.828861e-01 0.234 0 0
Polymerase switching R-HSA-69091 5.916710e-01 0.228 0 0
Leading Strand Synthesis R-HSA-69109 5.916710e-01 0.228 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.916710e-01 0.228 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 5.916710e-01 0.228 0 0
Interleukin-35 Signalling R-HSA-8984722 5.916710e-01 0.228 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 5.916710e-01 0.228 0 0
Synthesis of GDP-mannose R-HSA-446205 5.916710e-01 0.228 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 5.916710e-01 0.228 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 5.916710e-01 0.228 0 0
Interleukin-15 signaling R-HSA-8983432 5.916710e-01 0.228 0 0
Pervasive developmental disorders R-HSA-9005895 5.916710e-01 0.228 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.916710e-01 0.228 0 0
Disorders of Nervous System Development R-HSA-9697154 5.916710e-01 0.228 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 5.916710e-01 0.228 0 0
OAS antiviral response R-HSA-8983711 5.916710e-01 0.228 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.981514e-01 0.223 0 0
Activation of the pre-replicative complex R-HSA-68962 5.981514e-01 0.223 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 5.981514e-01 0.223 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 5.981514e-01 0.223 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 5.981514e-01 0.223 0 0
Mitochondrial biogenesis R-HSA-1592230 5.989484e-01 0.223 0 0
Metal ion SLC transporters R-HSA-425410 6.064308e-01 0.217 0 0
Molecules associated with elastic fibres R-HSA-2129379 6.129926e-01 0.213 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 6.139127e-01 0.212 0 0
Formation of axial mesoderm R-HSA-9796292 6.139127e-01 0.212 0 0
Frs2-mediated activation R-HSA-170968 6.139127e-01 0.212 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 6.139127e-01 0.212 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 6.139127e-01 0.212 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 6.139127e-01 0.212 0 0
Maturation of nucleoprotein R-HSA-9683610 6.139127e-01 0.212 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 6.139127e-01 0.212 0 0
Transcription of the HIV genome R-HSA-167172 6.147621e-01 0.211 0 0
CRMPs in Sema3A signaling R-HSA-399956 6.349441e-01 0.197 0 0
Removal of the Flap Intermediate R-HSA-69166 6.349441e-01 0.197 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 6.349441e-01 0.197 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 6.349441e-01 0.197 0 0
Prolactin receptor signaling R-HSA-1170546 6.349441e-01 0.197 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 6.349441e-01 0.197 0 0
Malate-aspartate shuttle R-HSA-9856872 6.349441e-01 0.197 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 6.349441e-01 0.197 0 0
Non-canonical inflammasome activation R-HSA-9686114 6.349441e-01 0.197 0 0
HDL assembly R-HSA-8963896 6.349441e-01 0.197 0 0
Zinc transporters R-HSA-435354 6.349441e-01 0.197 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 6.349441e-01 0.197 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 6.414078e-01 0.193 0 0
Formation of the cornified envelope R-HSA-6809371 6.523986e-01 0.185 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 6.548311e-01 0.184 0 0
G beta:gamma signalling through BTK R-HSA-8964315 6.548311e-01 0.184 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.548311e-01 0.184 0 0
Protein lipoylation R-HSA-9857492 6.548311e-01 0.184 0 0
Other semaphorin interactions R-HSA-416700 6.548311e-01 0.184 0 0
Stimuli-sensing channels R-HSA-2672351 6.622092e-01 0.179 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 6.632930e-01 0.178 0 0
Nucleotide biosynthesis R-HSA-8956320 6.632930e-01 0.178 0 0
Ca2+ pathway R-HSA-4086398 6.637419e-01 0.178 1 1
Diseases of carbohydrate metabolism R-HSA-5663084 6.637419e-01 0.178 0 0
Hyaluronan metabolism R-HSA-2142845 6.681518e-01 0.175 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 6.736359e-01 0.172 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 6.736359e-01 0.172 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 6.736359e-01 0.172 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.736359e-01 0.172 0 0
Killing mechanisms R-HSA-9664420 6.736359e-01 0.172 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.736359e-01 0.172 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.736359e-01 0.172 0 0
Differentiation of T cells R-HSA-9945266 6.736359e-01 0.172 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 6.736359e-01 0.172 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.736359e-01 0.172 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 6.736359e-01 0.172 0 0
Activation of SMO R-HSA-5635838 6.736359e-01 0.172 0 0
Attachment and Entry R-HSA-9678110 6.736359e-01 0.172 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 6.809076e-01 0.167 0 0
Mitochondrial protein degradation R-HSA-9837999 6.908281e-01 0.161 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 6.914173e-01 0.160 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.914173e-01 0.160 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 6.914173e-01 0.160 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 6.914173e-01 0.160 0 0
Fibronectin matrix formation R-HSA-1566977 6.914173e-01 0.160 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.914173e-01 0.160 0 0
Disorders of Developmental Biology R-HSA-9675151 6.914173e-01 0.160 0 0
Galactose catabolism R-HSA-70370 6.914173e-01 0.160 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 6.932598e-01 0.159 0 0
RNA Polymerase III Transcription R-HSA-74158 6.932598e-01 0.159 0 0
Triglyceride catabolism R-HSA-163560 6.932598e-01 0.159 0 0
G1/S-Specific Transcription R-HSA-69205 6.932598e-01 0.159 0 0
FGFR2 mutant receptor activation R-HSA-1839126 6.932598e-01 0.159 0 0
Voltage gated Potassium channels R-HSA-1296072 7.052143e-01 0.152 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 7.052143e-01 0.152 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 7.082309e-01 0.150 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 7.082309e-01 0.150 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 7.082309e-01 0.150 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 7.082309e-01 0.150 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 7.082309e-01 0.150 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 7.082309e-01 0.150 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 7.082309e-01 0.150 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.082309e-01 0.150 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 7.082309e-01 0.150 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 7.136498e-01 0.147 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 7.140762e-01 0.146 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.166795e-01 0.145 0 0
Elastic fibre formation R-HSA-1566948 7.167778e-01 0.145 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 7.167778e-01 0.145 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 7.233369e-01 0.141 0 0
Extension of Telomeres R-HSA-180786 7.233369e-01 0.141 0 0
Regulation of beta-cell development R-HSA-186712 7.233369e-01 0.141 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 7.233369e-01 0.141 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 7.241293e-01 0.140 0 0
PKA activation in glucagon signalling R-HSA-164378 7.241293e-01 0.140 0 0
Mismatch Repair R-HSA-5358508 7.241293e-01 0.140 0 0
Apoptotic factor-mediated response R-HSA-111471 7.241293e-01 0.140 0 0
Ion channel transport R-HSA-983712 7.261951e-01 0.139 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 7.273131e-01 0.138 0 0
Pentose phosphate pathway R-HSA-71336 7.279575e-01 0.138 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 7.279575e-01 0.138 0 0
Regulation of insulin secretion R-HSA-422356 7.288732e-01 0.137 0 0
Regulation of PTEN gene transcription R-HSA-8943724 7.324860e-01 0.135 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.328970e-01 0.135 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 7.387609e-01 0.131 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 7.391623e-01 0.131 0 0
E2F mediated regulation of DNA replication R-HSA-113510 7.391623e-01 0.131 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 7.391623e-01 0.131 0 0
Methionine salvage pathway R-HSA-1237112 7.391623e-01 0.131 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 7.391623e-01 0.131 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 7.391623e-01 0.131 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 7.491956e-01 0.125 0 0
Mitochondrial protein import R-HSA-1268020 7.500667e-01 0.125 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 7.533771e-01 0.123 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 7.533771e-01 0.123 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 7.533771e-01 0.123 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 7.533771e-01 0.123 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 7.533771e-01 0.123 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 7.533771e-01 0.123 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 7.533771e-01 0.123 0 0
Protein hydroxylation R-HSA-9629569 7.533771e-01 0.123 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 7.585035e-01 0.120 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 7.592699e-01 0.120 0 0
HIV Transcription Initiation R-HSA-167161 7.592699e-01 0.120 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 7.592699e-01 0.120 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.592699e-01 0.120 0 0
Intra-Golgi traffic R-HSA-6811438 7.592699e-01 0.120 0 0
Scavenging by Class A Receptors R-HSA-3000480 7.592699e-01 0.120 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 7.655239e-01 0.116 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.668179e-01 0.115 0 0
Lagging Strand Synthesis R-HSA-69186 7.668179e-01 0.115 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 7.668179e-01 0.115 0 0
ERK/MAPK targets R-HSA-198753 7.668179e-01 0.115 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.668179e-01 0.115 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 7.689919e-01 0.114 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 7.773423e-01 0.109 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 7.773423e-01 0.109 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.783702e-01 0.109 0 0
Amine ligand-binding receptors R-HSA-375280 7.874132e-01 0.104 0 0
Methylation R-HSA-156581 7.874132e-01 0.104 0 0
Notch-HLH transcription pathway R-HSA-350054 7.915442e-01 0.102 0 0
LDL clearance R-HSA-8964038 7.915442e-01 0.102 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 7.915442e-01 0.102 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.961298e-01 0.099 0 0
Termination of O-glycan biosynthesis R-HSA-977068 8.029070e-01 0.095 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 8.029070e-01 0.095 0 0
Interleukin-20 family signaling R-HSA-8854691 8.029070e-01 0.095 0 0
Formation of the ureteric bud R-HSA-9830674 8.029070e-01 0.095 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 8.029070e-01 0.095 0 0
Mitochondrial mRNA modification R-HSA-9937008 8.029070e-01 0.095 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.045286e-01 0.094 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.045286e-01 0.094 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 8.112661e-01 0.091 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.126182e-01 0.090 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.136511e-01 0.090 0 0
Complex III assembly R-HSA-9865881 8.136511e-01 0.090 0 0
Metabolism of amino acids and derivatives R-HSA-71291 8.138025e-01 0.089 0 0
ECM proteoglycans R-HSA-3000178 8.179479e-01 0.087 0 0
GPER1 signaling R-HSA-9634597 8.204075e-01 0.086 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 8.238102e-01 0.084 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 8.238102e-01 0.084 0 0
TGFBR3 expression R-HSA-9839394 8.238102e-01 0.084 0 0
Hyaluronan degradation R-HSA-2160916 8.238102e-01 0.084 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 8.244276e-01 0.084 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 8.244276e-01 0.084 0 0
Bacterial Infection Pathways R-HSA-9824439 8.283992e-01 0.082 0 0
Collagen formation R-HSA-1474290 8.327930e-01 0.079 0 0
TRP channels R-HSA-3295583 8.334159e-01 0.079 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.334159e-01 0.079 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 8.334159e-01 0.079 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 8.424986e-01 0.074 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 8.424986e-01 0.074 0 0
Maturation of hRSV A proteins R-HSA-9828806 8.424986e-01 0.074 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.510865e-01 0.070 0 0
Telomere Extension By Telomerase R-HSA-171319 8.510865e-01 0.070 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.510865e-01 0.070 0 0
Pyroptosis R-HSA-5620971 8.510865e-01 0.070 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.551505e-01 0.068 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 8.592066e-01 0.066 0 0
Thyroxine biosynthesis R-HSA-209968 8.592066e-01 0.066 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 8.592066e-01 0.066 0 0
Nuclear Receptor transcription pathway R-HSA-383280 8.592929e-01 0.066 0 0
Integrin cell surface interactions R-HSA-216083 8.592929e-01 0.066 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.621395e-01 0.064 0 0
Interferon gamma signaling R-HSA-877300 8.650695e-01 0.063 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 8.668845e-01 0.062 0 0
Aspartate and asparagine metabolism R-HSA-8963693 8.741441e-01 0.058 0 0
DAG1 glycosylations R-HSA-8931838 8.810082e-01 0.055 0 0
DNA strand elongation R-HSA-69190 8.810082e-01 0.055 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 8.874983e-01 0.052 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 8.874983e-01 0.052 0 0
Activation of ATR in response to replication stress R-HSA-176187 8.874983e-01 0.052 0 0
Cardiogenesis R-HSA-9733709 8.874983e-01 0.052 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 8.874983e-01 0.052 0 0
Triglyceride metabolism R-HSA-8979227 8.886904e-01 0.051 0 0
SLC transporter disorders R-HSA-5619102 8.918614e-01 0.050 0 0
tRNA Aminoacylation R-HSA-379724 8.935260e-01 0.049 0 0
Signaling by Retinoic Acid R-HSA-5362517 8.935260e-01 0.049 0 0
Resolution of D-Loop Structures R-HSA-5693537 8.936348e-01 0.049 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.936348e-01 0.049 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.936348e-01 0.049 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.936348e-01 0.049 0 0
Platelet homeostasis R-HSA-418346 8.958640e-01 0.048 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 8.994369e-01 0.046 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 8.994369e-01 0.046 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.994369e-01 0.046 0 0
RA biosynthesis pathway R-HSA-5365859 8.994369e-01 0.046 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.994369e-01 0.046 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.026164e-01 0.044 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 9.049229e-01 0.043 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.049229e-01 0.043 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.049229e-01 0.043 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.049229e-01 0.043 0 0
Complex I biogenesis R-HSA-6799198 9.068850e-01 0.042 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.101099e-01 0.041 0 0
Cardiac conduction R-HSA-5576891 9.135309e-01 0.039 0 0
Neurotransmitter release cycle R-HSA-112310 9.146776e-01 0.039 0 0
Collagen chain trimerization R-HSA-8948216 9.150142e-01 0.039 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 9.196512e-01 0.036 0 0
G alpha (q) signalling events R-HSA-416476 9.206413e-01 0.036 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 9.240355e-01 0.034 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.257212e-01 0.034 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 9.281808e-01 0.032 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 9.281808e-01 0.032 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.281808e-01 0.032 0 0
Maturation of spike protein R-HSA-9694548 9.321002e-01 0.031 0 0
PKMTs methylate histone lysines R-HSA-3214841 9.321002e-01 0.031 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.352330e-01 0.029 0 0
Metabolism of cofactors R-HSA-8978934 9.352330e-01 0.029 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.358058e-01 0.029 0 0
Diseases of glycosylation R-HSA-3781865 9.361369e-01 0.029 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.411206e-01 0.026 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.435827e-01 0.025 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.457541e-01 0.024 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.487153e-01 0.023 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.487153e-01 0.023 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.509019e-01 0.022 0 0
Diseases of DNA repair R-HSA-9675135 9.515151e-01 0.022 0 0
PI Metabolism R-HSA-1483255 9.515151e-01 0.022 0 0
tRNA processing R-HSA-72306 9.526937e-01 0.021 0 0
Interleukin-10 signaling R-HSA-6783783 9.531334e-01 0.021 0 0
Synthesis of PC R-HSA-1483191 9.541621e-01 0.020 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.552679e-01 0.020 0 0
NGF-stimulated transcription R-HSA-9031628 9.566648e-01 0.019 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.566648e-01 0.019 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.612681e-01 0.017 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.629112e-01 0.016 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.648072e-01 0.016 0 0
Keratinization R-HSA-6805567 9.690452e-01 0.014 0 0
Glucuronidation R-HSA-156588 9.690610e-01 0.014 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.692918e-01 0.014 0 0
Paracetamol ADME R-HSA-9753281 9.707510e-01 0.013 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.723487e-01 0.012 0 0
Metabolism of nucleotides R-HSA-15869 9.744326e-01 0.011 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.766375e-01 0.010 0 0
Peptide hormone metabolism R-HSA-2980736 9.773041e-01 0.010 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.779140e-01 0.010 0 0
Aquaporin-mediated transport R-HSA-445717 9.791209e-01 0.009 0 0
Collagen degradation R-HSA-1442490 9.791209e-01 0.009 0 0
Drug ADME R-HSA-9748784 9.792085e-01 0.009 0 0
Heme signaling R-HSA-9707616 9.802618e-01 0.009 0 0
GPCR downstream signalling R-HSA-388396 9.811193e-01 0.008 0 0
G alpha (s) signalling events R-HSA-418555 9.811612e-01 0.008 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.823602e-01 0.008 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.827013e-01 0.008 0 0
Potassium Channels R-HSA-1296071 9.827013e-01 0.008 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.842358e-01 0.007 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.844139e-01 0.007 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.850975e-01 0.007 0 0
Kidney development R-HSA-9830369 9.850975e-01 0.007 0 0
Nicotinate metabolism R-HSA-196807 9.850975e-01 0.007 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.850975e-01 0.007 0 0
Respiratory electron transport R-HSA-611105 9.855532e-01 0.006 0 0
O-linked glycosylation of mucins R-HSA-913709 9.859121e-01 0.006 0 0
PPARA activates gene expression R-HSA-1989781 9.872866e-01 0.006 0 0
COPII-mediated vesicle transport R-HSA-204005 9.874104e-01 0.006 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.876799e-01 0.005 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.882882e-01 0.005 0 0
Adipogenesis R-HSA-9843745 9.887242e-01 0.005 0 0
Aspirin ADME R-HSA-9749641 9.893647e-01 0.005 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.919304e-01 0.004 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.919718e-01 0.004 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.924109e-01 0.003 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.942719e-01 0.002 0 0
Signaling by GPCR R-HSA-372790 9.968929e-01 0.001 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.972447e-01 0.001 0 0
Mitochondrial translation elongation R-HSA-5389840 9.975382e-01 0.001 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.976009e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.977187e-01 0.001 0 0
Mitochondrial translation initiation R-HSA-5368286 9.978005e-01 0.001 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.979210e-01 0.001 0 0
O-linked glycosylation R-HSA-5173105 9.983150e-01 0.001 0 0
Mitochondrial translation R-HSA-5368287 9.983982e-01 0.001 0 0
Diseases of metabolism R-HSA-5668914 9.987891e-01 0.001 0 0
Mitochondrial translation termination R-HSA-5419276 9.988815e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.989428e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.990008e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.990015e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.992537e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.992739e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.994224e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.995324e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.998777e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999331e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999368e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.999439e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999728e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999787e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999885e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 9.999886e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999959e-01 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 9.999963e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999963e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999998e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways