BUB1

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
O00488 S40 Sugiyama ZNF593 ZT86 KAKRRRPDLDEIHRELRPQGsARPQPDPNAEFDPDLPGGGL
O43683 S176 EPSD|PSP BUB1 BUB1L ARTSEPLHNVQVLNQMItSKsNPGNNMACISKNQGSELsGV
O43683 S194 Sugiyama BUB1 BUB1L SKsNPGNNMACISKNQGSELsGVIsSACDKESNMERRVItI
O43683 S198 EPSD|PSP|Sugiyama BUB1 BUB1L PGNNMACISKNQGSELsGVIsSACDKESNMERRVItISKSE
O43683 S247 Sugiyama BUB1 BUB1L SKVDVEQVVMYCKEKLIRGEsEFsFEELRAQKYNQRRKHEQ
O43683 S250 Sugiyama BUB1 BUB1L DVEQVVMYCKEKLIRGEsEFsFEELRAQKYNQRRKHEQWVN
O43683 S307 Sugiyama BUB1 BUB1L QLLKQKMDELHKKLHQVVEtsHEDLPAsQERsEVNPARMGP
O43683 S314 Sugiyama BUB1 BUB1L DELHKKLHQVVEtsHEDLPAsQERsEVNPARMGPSVGsQQE
O43683 S331 Sugiyama BUB1 BUB1L LPAsQERsEVNPARMGPSVGsQQELRAPCLPVTYQQTPVNM
O43683 S402 Sugiyama BUB1 BUB1L IAPPVPLKAQTVTDSMFAVAsKDAGCVNKstHEFKPQsGAE
O43683 S419 EPSD|PSP BUB1 BUB1L AVAsKDAGCVNKstHEFKPQsGAEIKEGCETHKVANtssFH
O43683 S454 EPSD|PSP BUB1 BUB1L NtssFHttPNtsLGMVQAtPsKVQPsPTVHTKEALGFIMNM
O43683 S510 EPSD|PSP BUB1 BUB1L WQsLDQNEDAFEAQFQKNVRssGAWGVNKIISSLSsAFHVF
O43683 S511 EPSD|PSP BUB1 BUB1L QsLDQNEDAFEAQFQKNVRssGAWGVNKIISSLSsAFHVFE
O43683 S525 EPSD|PSP BUB1 BUB1L QKNVRssGAWGVNKIISSLSsAFHVFEDGNKENyGLPQPKN
O43683 S563 EPSD|PSP BUB1 BUB1L PKNKPTGARtFGERSVSRLPsKPKEEVPHAEEFLDDSTVWG
O43683 S618 EPSD|PSP BUB1 BUB1L GDFtsAAQLAstPFHKLPVEsVHILEDKENVVAKQCTQAtL
O43683 S667 EPSD|PSP BUB1 BUB1L VPsRDGKFsPIQEKsPKQALsSHMYSASLLRLsQPAAGGVL
O43683 S679 EPSD|PSP BUB1 BUB1L EKsPKQALsSHMYSASLLRLsQPAAGGVLTCEAELGVEACR
O43683 S752 EPSD|PSP BUB1 BUB1L DAPNFIVGNPWDDKLIFKLLsGLSKPVSSYPNTFEWQCKLP
O43683 S969 SIGNOR|EPSD|PSP BUB1 BUB1L QSIDMKLFPKGtIFTAKCETsGFQCVEMLSNKPWNYQIDYF
O43683 T148 EPSD|PSP BUB1 BUB1L NQAEPREFLQQQYRLFQTRLtETHLPAQARTSEPLHNVQVL
O43683 T173 EPSD|PSP BUB1 BUB1L PAQARTSEPLHNVQVLNQMItSKsNPGNNMACISKNQGSEL
O43683 T213 EPSD|PSP BUB1 BUB1L LsGVIsSACDKESNMERRVItISKSEYSVHSSLASKVDVEQ
O43683 T552 EPSD|PSP BUB1 BUB1L DGNKENyGLPQPKNKPTGARtFGERSVSRLPsKPKEEVPHA
O43683 T589 EPSD|PSP BUB1 BUB1L VPHAEEFLDDSTVWGIRCNKtLAPsPKsPGDFtsAAQLAst
O43683 T960 EPSD|PSP BUB1 BUB1L AGLALIDLGQSIDMKLFPKGtIFTAKCETsGFQCVEMLSNK
O43684 S19 EPSD|PSP BUB3 __MTGSNEFKLNQPPEDGISsVKFSPNTSQFLLVSSWDTSV
P00558 S390 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 IIGGGDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPG
P00558 S399 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 CCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDALsNI__
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04406 T104 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 KIKWGDAGAEyVVEstGVFttMEKAGAHLQGGAKRVIIsAP
P04406 T211 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 PsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtGM
P04406 T99 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 ERDPsKIKWGDAGAEyVVEstGVFttMEKAGAHLQGGAKRV
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P07205 S390 Sugiyama PGK2 PGKB VIGGGDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPG
P07205 S399 Sugiyama PGK2 PGKB CCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEALSNM__
P07437 S75 Sugiyama TUBB TUBB5 OK/SW-cl.56 tGGKyVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
P07437 T72 Sugiyama TUBB TUBB5 OK/SW-cl.56 NEAtGGKyVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVF
P07900 T171 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA ITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGTKVILHLK
P08238 S460 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 T166 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB ITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGTKVILHLK
P08238 Y457 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB LKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMK
P0C0S8 T121 SIGNOR|EPSD H2AC11 H2AFP HIST1H2AG; H2AC13 H2AFC HIST1H2AI; H2AC15 H2AFD HIST1H2AK; H2AC16 H2AFI HIST1H2AL; H2AC17 H2AFN HIST1H2AM VtIAQGGVLPNIQAVLLPKKtEsHHKAKGK___________
P14618 S202 Sugiyama PKM OIP3 PK2 PK3 PKM2 SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs
P15880 T278 Sugiyama RPS2 RPS4 EtVFtKsPyQEFtDHLVKtHtRVsVQRtQAPAVATt_____
P15880 T285 Sugiyama RPS2 RPS4 PyQEFtDHLVKtHtRVsVQRtQAPAVATt____________
P22059 S190 Sugiyama OSBP OSBP1 QRWVTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNT
P22059 S193 Sugiyama OSBP OSBP1 VTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNTLRT
P23396 T242 Sugiyama RPS3 OK/SW-cl.26 PIsEQKGGKPEPPAMPQPVPtA___________________
P26038 S527 Sugiyama MSN ERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHAE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P36578 S66 Sugiyama RPL4 RPL1 KNNRQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGGGtHR
P36578 T69 Sugiyama RPL4 RPL1 RQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGGGtHRsGQ
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P40763 S727 PSP STAT3 APRF KTKFICVtPttCsNtIDLPMsPRTLDSLMQFGNNGEGAEPS
P41221 S132 Sugiyama WNT5A RWNCSTVDNTSVFGRVMQIGsRETAFTYAVSAAGVVNAMSR
P47914 T151 Sugiyama RPL29 DQTKAQAAAPAsVPAQAPKRtQAPtKAsE____________
P49411 T433 Sugiyama TUFM LRQPMILEKGQRFTLRDGNRtIGTGLVTNTLAMTEEEKNIK
P50991 T69 Sugiyama CCT4 CCTD SRB RtsLGPKGMDKMIQDGKGDVtItNDGAtILKQMQVLHPAAR
P50991 T71 Sugiyama CCT4 CCTD SRB sLGPKGMDKMIQDGKGDVtItNDGAtILKQMQVLHPAARML
P50991 T76 Sugiyama CCT4 CCTD SRB GMDKMIQDGKGDVtItNDGAtILKQMQVLHPAARMLVELSK
P60709 T106 Sugiyama ACTB WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P62263 S137 Sugiyama RPS14 PRO2640 RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62899 Y108 Sugiyama RPL31 LSRKRNEDEDsPNKLytLVtyVPVttFKNLQtVNVDEN___
P63167 S21 Sugiyama DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1 MCDRKAVIKNADMsEEMQQDsVECAtQALEKYNIEKDIAAH
P63167 T26 Sugiyama DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1 AVIKNADMsEEMQQDsVECAtQALEKYNIEKDIAAHIKKEF
P63261 T106 Sugiyama ACTG1 ACTG WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P67809 T108 Sugiyama YBX1 NSEP1 YB1 QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P68363 T73 Sugiyama TUBA1B FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363 T80 Sugiyama TUBA1B KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
P68363 T82 Sugiyama TUBA1B VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
P68363 Y83 Sugiyama TUBA1B PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q12834 S153 SIGNOR|iPTMNet|EPSD|PSP CDC20 LsGKPQNAPEGYQNRLKVLYsQKAtPGSsRKTCRYIPsLPD
Q12834 S161 SIGNOR|iPTMNet|EPSD|PSP CDC20 PEGYQNRLKVLYsQKAtPGSsRKTCRYIPsLPDRILDAPEI
Q12834 S41 SIGNOR|iPTMNet|EPSD|PSP CDC20 PNAPPARWQRKAKEAAGPAPsPMRAANRSHSAGRtPGRtPG
Q12834 S72 SIGNOR|iPTMNet|EPSD|PSP CDC20 AGRtPGRtPGKSSSKVQttPsKPGGDRYIPHRSAAQMEVAs
Q12834 S92 SIGNOR|iPTMNet|EPSD|PSP CDC20 sKPGGDRYIPHRSAAQMEVAsFLLSKENQPENsQtPtKKEH
Q12834 T157 SIGNOR|iPTMNet|EPSD|PSP CDC20 PQNAPEGYQNRLKVLYsQKAtPGSsRKTCRYIPsLPDRILD
Q13509 S75 Sugiyama TUBB3 TUBB4 SSHKYVPRAILVDLEPGtMDsVRSGAFGHLFRPDNFIFGQS
Q13509 T72 Sugiyama TUBB3 TUBB4 NEASSHKYVPRAILVDLEPGtMDsVRSGAFGHLFRPDNFIF
Q13885 S75 Sugiyama TUBB2A TUBB2 AGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q13885 T72 Sugiyama TUBB2A TUBB2 NEAAGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVF
Q14568 T171 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 ITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGTKVILHLK
Q71U36 T73 Sugiyama TUBA1A TUBA3 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36 T80 Sugiyama TUBA1A TUBA3 KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q71U36 T82 Sugiyama TUBA1A TUBA3 VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
Q71U36 Y83 Sugiyama TUBA1A TUBA3 PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q8NFD5 S1744 Sugiyama ARID1B BAF250B DAN15 KIAA1235 OSA2 ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q8WW12 T66 Sugiyama PCNP sRsAEKRsAEEEAADLPTKPtKISKFGFAIGsQtTKKASAI
Q99832 T458 Sugiyama CCT7 CCTH NIP7-1 yAKALEIIPRQLCDNAGFDAtNILNKLRARHAQGGTWYGVD
Q9BQE3 T73 Sugiyama TUBA1C TUBA6 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3 T80 Sugiyama TUBA1C TUBA6 KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q9BQE3 T82 Sugiyama TUBA1C TUBA6 VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
Q9BQE3 Y83 Sugiyama TUBA1C TUBA6 PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q9BVA1 S75 Sugiyama TUBB2B tGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q9BVA1 T72 Sugiyama TUBB2B NEAtGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVF
Q9H1J7 S111 Sugiyama WNT5B RWNCSTADNASVFGRVMQIGsRETAFTHAVSAAGVVNAISR
Q9UMX5 T130 Sugiyama NENF CIR2 SPUF LTHDTTGLTAKELEALDEVFtKVYKAKYPIVGYTARRILNE
Q9Y2T7 T143 Sugiyama YBX2 CSDA3 MSY2 QtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEATNVTGP
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Axon guidance R-HSA-422475 4.416590e-10 9.355 0 0
Nervous system development R-HSA-9675108 2.196173e-09 8.658 0 0
G alpha (12/13) signalling events R-HSA-416482 1.374156e-07 6.862 0 0
Cellular Senescence R-HSA-2559583 1.807935e-07 6.743 0 0
NRAGE signals death through JNK R-HSA-193648 2.664308e-07 6.574 0 0
Cell Cycle, Mitotic R-HSA-69278 1.198503e-06 5.921 1 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.226673e-06 5.911 0 0
Signal Transduction R-HSA-162582 1.538530e-06 5.813 1 0
Apoptotic execution phase R-HSA-75153 5.135865e-06 5.289 0 0
Cell Cycle R-HSA-1640170 7.671869e-06 5.115 1 0
M Phase R-HSA-68886 1.065151e-05 4.973 1 0
L1CAM interactions R-HSA-373760 1.463383e-05 4.835 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.764795e-05 4.753 0 0
Recycling pathway of L1 R-HSA-437239 3.031019e-05 4.518 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.996656e-05 4.523 0 0
Chromatin modifying enzymes R-HSA-3247509 5.210872e-05 4.283 0 0
Chromatin organization R-HSA-4839726 5.899016e-05 4.229 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 5.870828e-05 4.231 1 1
p75 NTR receptor-mediated signalling R-HSA-193704 5.918934e-05 4.228 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 7.602863e-05 4.119 1 1
Mitotic Prometaphase R-HSA-68877 1.025281e-04 3.989 1 1
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.165031e-04 3.934 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.165031e-04 3.934 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.165031e-04 3.934 0 0
Signaling by RAS mutants R-HSA-6802949 1.165031e-04 3.934 0 0
HCMV Early Events R-HSA-9609690 1.268395e-04 3.897 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.316486e-04 3.881 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.528444e-04 3.816 0 0
Selective autophagy R-HSA-9663891 1.564540e-04 3.806 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.620351e-04 3.790 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.668981e-04 3.778 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.741356e-04 3.759 0 0
Separation of Sister Chromatids R-HSA-2467813 1.862914e-04 3.730 1 1
Kinesins R-HSA-983189 2.160977e-04 3.665 0 0
Mitotic Anaphase R-HSA-68882 2.151834e-04 3.667 1 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.076200e-04 3.683 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.293514e-04 3.639 1 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.546766e-04 3.594 0 0
Semaphorin interactions R-HSA-373755 3.173168e-04 3.499 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.672640e-04 3.435 0 0
RMTs methylate histone arginines R-HSA-3214858 3.672640e-04 3.435 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 3.743085e-04 3.427 0 0
HDACs deacetylate histones R-HSA-3214815 4.258295e-04 3.371 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 4.611054e-04 3.336 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 5.623895e-04 3.250 0 0
Death Receptor Signaling R-HSA-73887 5.765607e-04 3.239 0 0
Gap junction trafficking and regulation R-HSA-157858 7.382609e-04 3.132 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 7.545092e-04 3.122 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 7.828384e-04 3.106 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 7.906298e-04 3.102 0 0
MAP2K and MAPK activation R-HSA-5674135 9.770163e-04 3.010 0 0
Signaling by RAF1 mutants R-HSA-9656223 9.770163e-04 3.010 0 0
Signaling by Hippo R-HSA-2028269 9.611459e-04 3.017 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 9.611459e-04 3.017 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 9.770163e-04 3.010 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 9.882109e-04 3.005 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.036155e-03 2.985 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.105389e-03 2.956 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.220521e-03 2.913 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.263585e-03 2.898 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.203675e-03 2.919 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.266494e-03 2.897 0 0
Defective pyroptosis R-HSA-9710421 1.283840e-03 2.891 0 0
Metalloprotease DUBs R-HSA-5689901 1.323149e-03 2.878 0 0
Gap junction trafficking R-HSA-190828 1.464021e-03 2.834 0 0
HCMV Infection R-HSA-9609646 1.485989e-03 2.828 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.634332e-03 2.787 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.769921e-03 2.752 1 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.826487e-03 2.738 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.826487e-03 2.738 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.887932e-03 2.724 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.155963e-03 2.666 0 0
MAPK family signaling cascades R-HSA-5683057 2.179607e-03 2.662 0 0
DNA methylation R-HSA-5334118 2.182007e-03 2.661 0 0
EPH-Ephrin signaling R-HSA-2682334 2.322563e-03 2.634 0 0
Apoptosis R-HSA-109581 2.309519e-03 2.636 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.366868e-03 2.626 0 0
Cellular responses to stress R-HSA-2262752 2.531273e-03 2.597 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.532678e-03 2.596 0 0
Programmed Cell Death R-HSA-5357801 2.761775e-03 2.559 0 0
Aggrephagy R-HSA-9646399 2.912972e-03 2.536 0 0
DCC mediated attractive signaling R-HSA-418885 2.938845e-03 2.532 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.182878e-03 2.497 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.313959e-03 2.480 1 1
Amplification of signal from the kinetochores R-HSA-141424 3.313959e-03 2.480 1 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 3.302943e-03 2.481 0 0
Macroautophagy R-HSA-1632852 3.161520e-03 2.500 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.211190e-03 2.493 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.464245e-03 2.460 0 0
Autophagy R-HSA-9612973 3.644927e-03 2.438 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.769326e-03 2.424 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 4.470866e-03 2.350 0 0
G2/M Transition R-HSA-69275 4.291528e-03 2.367 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.568632e-03 2.340 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.568632e-03 2.340 0 0
MHC class II antigen presentation R-HSA-2132295 4.589479e-03 2.338 0 0
Mitotic G2-G2/M phases R-HSA-453274 4.759104e-03 2.322 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 4.775142e-03 2.321 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 5.115374e-03 2.291 0 0
RAF activation R-HSA-5673000 5.127953e-03 2.290 0 0
Netrin-1 signaling R-HSA-373752 5.282135e-03 2.277 0 0
Membrane Trafficking R-HSA-199991 5.953511e-03 2.225 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 5.590258e-03 2.253 0 0
Cellular responses to stimuli R-HSA-8953897 6.140757e-03 2.212 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 6.500081e-03 2.187 0 0
Packaging Of Telomere Ends R-HSA-171306 6.937045e-03 2.159 0 0
PRC2 methylates histones and DNA R-HSA-212300 6.580036e-03 2.182 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 6.560313e-03 2.183 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 7.128158e-03 2.147 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 6.937045e-03 2.159 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 6.558014e-03 2.183 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 7.069719e-03 2.151 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 7.411214e-03 2.130 0 0
TCF dependent signaling in response to WNT R-HSA-201681 7.627090e-03 2.118 0 0
Rap1 signalling R-HSA-392517 7.724409e-03 2.112 0 0
Oncogenic MAPK signaling R-HSA-6802957 8.250223e-03 2.084 0 0
Cell Cycle Checkpoints R-HSA-69620 8.172793e-03 2.088 1 0
Regulation of PTEN gene transcription R-HSA-8943724 8.202147e-03 2.086 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 8.023721e-03 2.096 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 8.528728e-03 2.069 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 7.962854e-03 2.099 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 8.899607e-03 2.051 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 9.770882e-03 2.010 0 0
Cell junction organization R-HSA-446728 9.826754e-03 2.008 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.088202e-02 1.963 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.037109e-02 1.984 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.101160e-02 1.958 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.026307e-02 1.989 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.037109e-02 1.984 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 1.112060e-02 1.954 0 0
Signaling by NOTCH1 R-HSA-1980143 1.099093e-02 1.959 0 0
Gene expression (Transcription) R-HSA-74160 1.104376e-02 1.957 0 0
Post NMDA receptor activation events R-HSA-438064 1.026307e-02 1.989 0 0
HATs acetylate histones R-HSA-3214847 1.080287e-02 1.966 0 0
UCH proteinases R-HSA-5689603 1.099093e-02 1.959 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.234149e-02 1.909 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.253465e-02 1.902 0 0
Cell-Cell communication R-HSA-1500931 1.255870e-02 1.901 0 0
Meiotic synapsis R-HSA-1221632 1.292263e-02 1.889 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.316807e-02 1.880 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.439237e-02 1.842 0 0
PKR-mediated signaling R-HSA-9833482 1.472387e-02 1.832 0 0
Protein folding R-HSA-391251 1.539789e-02 1.813 0 0
TBC/RABGAPs R-HSA-8854214 1.554543e-02 1.808 0 0
Generic Transcription Pathway R-HSA-212436 1.499997e-02 1.824 0 0
RNA Polymerase II Transcription R-HSA-73857 1.424994e-02 1.846 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.477124e-02 1.831 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.477124e-02 1.831 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.691102e-02 1.772 0 0
Regulation of TP53 Expression R-HSA-6804754 1.754140e-02 1.756 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.754140e-02 1.756 0 0
DSCAM interactions R-HSA-376172 1.754140e-02 1.756 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.813871e-02 1.741 0 0
Mitophagy R-HSA-5205647 1.837448e-02 1.736 0 0
Gap junction assembly R-HSA-190861 1.837448e-02 1.736 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.837448e-02 1.736 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.837613e-02 1.736 0 0
Formation of annular gap junctions R-HSA-196025 1.847156e-02 1.733 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 1.847156e-02 1.733 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.872352e-02 1.728 0 0
Nucleosome assembly R-HSA-774815 1.872352e-02 1.728 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.897667e-02 1.722 0 0
Adherens junctions interactions R-HSA-418990 1.910436e-02 1.719 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.271187e-02 1.644 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.254384e-02 1.647 0 0
Oncogene Induced Senescence R-HSA-2559585 2.038364e-02 1.691 0 0
RET signaling R-HSA-8853659 2.253682e-02 1.647 0 0
Cell-cell junction organization R-HSA-421270 2.045825e-02 1.689 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.290743e-02 1.640 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.293393e-02 1.640 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.293393e-02 1.640 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.293393e-02 1.640 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.293393e-02 1.640 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.293393e-02 1.640 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.293393e-02 1.640 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.312630e-02 1.636 0 0
Gap junction degradation R-HSA-190873 2.312630e-02 1.636 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 2.312630e-02 1.636 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.312630e-02 1.636 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 2.312630e-02 1.636 0 0
Deubiquitination R-HSA-5688426 2.357147e-02 1.628 0 0
Intraflagellar transport R-HSA-5620924 2.430408e-02 1.614 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 2.483796e-02 1.605 0 0
Cleavage of the damaged purine R-HSA-110331 2.483796e-02 1.605 0 0
FOXO-mediated transcription R-HSA-9614085 2.497742e-02 1.602 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 2.652774e-02 1.576 0 0
Folding of actin by CCT/TriC R-HSA-390450 2.835785e-02 1.547 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.650329e-02 1.577 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 2.957434e-02 1.529 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.949803e-02 1.530 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.949803e-02 1.530 0 0
Developmental Biology R-HSA-1266738 2.862736e-02 1.543 0 0
Specification of primordial germ cells R-HSA-9827857 2.573164e-02 1.590 0 0
Depurination R-HSA-73927 2.729074e-02 1.564 0 0
Diseases of programmed cell death R-HSA-9645723 2.647146e-02 1.577 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.053418e-02 1.515 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 3.074466e-02 1.512 0 0
mRNA 3'-end processing R-HSA-72187 3.338590e-02 1.476 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 3.338590e-02 1.476 0 0
Signaling by WNT R-HSA-195721 3.347042e-02 1.475 0 0
Specification of the neural plate border R-HSA-9834899 3.376239e-02 1.472 0 0
Germ layer formation at gastrulation R-HSA-9754189 3.376239e-02 1.472 0 0
Signaling by APC mutants R-HSA-4839744 3.416271e-02 1.466 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 3.416271e-02 1.466 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 3.416271e-02 1.466 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 3.416271e-02 1.466 0 0
Ub-specific processing proteases R-HSA-5689880 3.557953e-02 1.449 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 3.559137e-02 1.449 0 0
PKMTs methylate histone lysines R-HSA-3214841 3.559137e-02 1.449 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 3.697772e-02 1.432 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 3.697772e-02 1.432 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 3.697772e-02 1.432 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 3.697772e-02 1.432 0 0
Dopamine receptors R-HSA-390651 3.697772e-02 1.432 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 3.697772e-02 1.432 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.731837e-02 1.428 0 0
Signaling by GSK3beta mutants R-HSA-5339716 4.053325e-02 1.392 0 0
Diseases of mitotic cell cycle R-HSA-9675126 4.404279e-02 1.356 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 4.482789e-02 1.348 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 4.053325e-02 1.392 0 0
Signaling by AMER1 mutants R-HSA-4839748 4.053325e-02 1.392 0 0
Signaling by AXIN mutants R-HSA-4839735 4.053325e-02 1.392 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 4.226493e-02 1.374 0 0
Mitotic Prophase R-HSA-68875 4.052733e-02 1.392 0 0
Signaling by NOTCH R-HSA-157118 4.171866e-02 1.380 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 4.024136e-02 1.395 0 0
Signaling by ALK in cancer R-HSA-9700206 4.024136e-02 1.395 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 4.193762e-02 1.377 0 0
Depyrimidination R-HSA-73928 4.193762e-02 1.377 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 4.745828e-02 1.324 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 4.745828e-02 1.324 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 4.745828e-02 1.324 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 4.745828e-02 1.324 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 4.745828e-02 1.324 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 4.745828e-02 1.324 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 4.802136e-02 1.319 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 4.802136e-02 1.319 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 4.821797e-02 1.317 0 0
IRS activation R-HSA-74713 4.872737e-02 1.312 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.872737e-02 1.312 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 4.872737e-02 1.312 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 4.872737e-02 1.312 0 0
NrCAM interactions R-HSA-447038 4.872737e-02 1.312 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 4.882226e-02 1.311 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 4.882226e-02 1.311 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 4.882226e-02 1.311 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 4.882226e-02 1.311 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.895352e-02 1.310 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 5.094020e-02 1.293 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 5.094020e-02 1.293 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 5.261909e-02 1.279 0 0
DNA Double-Strand Break Repair R-HSA-5693532 5.281598e-02 1.277 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 5.492352e-02 1.260 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 6.162521e-02 1.210 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 6.162521e-02 1.210 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 7.140501e-02 1.146 0 0
Thromboxane signalling through TP receptor R-HSA-428930 6.566568e-02 1.183 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 6.075601e-02 1.216 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 6.723232e-02 1.172 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 6.503386e-02 1.187 0 0
Activation of HOX genes during differentiation R-HSA-5619507 7.050648e-02 1.152 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 7.050648e-02 1.152 0 0
RNA Polymerase I Transcription R-HSA-73864 7.083480e-02 1.150 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 6.374516e-02 1.196 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 6.515305e-02 1.186 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.782816e-02 1.169 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 6.162521e-02 1.210 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 6.162521e-02 1.210 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 6.136564e-02 1.212 0 0
HDMs demethylate histones R-HSA-3214842 7.210551e-02 1.142 0 0
Signaling by ROBO receptors R-HSA-376176 5.882222e-02 1.230 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 6.907882e-02 1.161 0 0
Signaling by PTK6 R-HSA-8848021 6.907882e-02 1.161 0 0
Rab regulation of trafficking R-HSA-9007101 6.925419e-02 1.160 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 6.162521e-02 1.210 0 0
Reproduction R-HSA-1474165 6.759577e-02 1.170 0 0
Formation of the anterior neural plate R-HSA-9823739 7.140501e-02 1.146 0 0
Base Excision Repair R-HSA-73884 6.461395e-02 1.190 0 0
Cell-extracellular matrix interactions R-HSA-446353 7.140501e-02 1.146 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 7.215405e-02 1.142 0 0
mRNA Splicing - Major Pathway R-HSA-72163 7.428820e-02 1.129 0 0
CREB phosphorylation R-HSA-199920 7.553141e-02 1.122 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 9.526373e-02 1.021 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 9.526373e-02 1.021 0 0
Diseases of Telomere Maintenance R-HSA-9673013 9.526373e-02 1.021 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 9.526373e-02 1.021 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 9.526373e-02 1.021 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 9.526373e-02 1.021 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 9.526373e-02 1.021 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 9.526373e-02 1.021 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 9.031703e-02 1.044 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 9.031703e-02 1.044 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 9.031703e-02 1.044 0 0
SOS-mediated signalling R-HSA-112412 9.031703e-02 1.044 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 8.038133e-02 1.095 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 8.038133e-02 1.095 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 8.981875e-02 1.047 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 8.590584e-02 1.066 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.008861e-01 0.996 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 8.375033e-02 1.077 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 8.971175e-02 1.047 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 7.800586e-02 1.108 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.811544e-02 1.008 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.811544e-02 1.008 0 0
TRP channels R-HSA-3295583 7.885441e-02 1.103 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.811544e-02 1.008 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 8.590584e-02 1.066 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.003641e-01 0.998 0 0
Telomere Maintenance R-HSA-157579 9.710291e-02 1.013 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 8.981875e-02 1.047 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.838652e-02 1.106 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 9.650606e-02 1.015 0 0
DNA Replication Pre-Initiation R-HSA-69002 8.707451e-02 1.060 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 9.487538e-02 1.023 0 0
Meiosis R-HSA-1500620 9.928434e-02 1.003 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 8.981875e-02 1.047 0 0
Pyroptosis R-HSA-5620971 9.325244e-02 1.030 0 0
Inhibition of PKR R-HSA-169131 9.526373e-02 1.021 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 7.885441e-02 1.103 0 0
Meiotic recombination R-HSA-912446 7.889806e-02 1.103 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 9.588688e-02 1.018 0 0
Muscle contraction R-HSA-397014 8.009201e-02 1.096 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.008861e-01 0.996 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 8.375033e-02 1.077 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 8.971175e-02 1.047 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 7.800586e-02 1.108 0 0
ER to Golgi Anterograde Transport R-HSA-199977 7.601300e-02 1.119 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.012070e-01 0.995 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.012070e-01 0.995 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.012070e-01 0.995 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.429171e-02 1.026 0 0
Gene Silencing by RNA R-HSA-211000 8.018739e-02 1.096 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.022720e-01 0.990 0 0
mRNA Splicing R-HSA-72172 1.028158e-01 0.988 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.039034e-01 0.983 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.053847e-01 0.977 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.058633e-01 0.975 0 0
Type I hemidesmosome assembly R-HSA-446107 1.058633e-01 0.975 0 0
Activation of RAS in B cells R-HSA-1169092 1.058633e-01 0.975 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.058633e-01 0.975 0 0
Interleukin-18 signaling R-HSA-9012546 1.058633e-01 0.975 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.058633e-01 0.975 0 0
Cilium Assembly R-HSA-5617833 1.082633e-01 0.966 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.087981e-01 0.963 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.087981e-01 0.963 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.091194e-01 0.962 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.099820e-01 0.959 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.099820e-01 0.959 0 0
Ephrin signaling R-HSA-3928664 1.099820e-01 0.959 0 0
Polo-like kinase mediated events R-HSA-156711 1.099820e-01 0.959 0 0
Apoptotic factor-mediated response R-HSA-111471 1.099820e-01 0.959 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 1.139022e-01 0.943 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.151021e-01 0.939 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 1.394403e-01 0.856 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 1.394403e-01 0.856 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 1.394403e-01 0.856 0 0
WNT mediated activation of DVL R-HSA-201688 1.220609e-01 0.913 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 1.388094e-01 0.858 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 1.560166e-01 0.807 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 1.735979e-01 0.760 0 0
ERKs are inactivated R-HSA-202670 1.735979e-01 0.760 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 1.430735e-01 0.844 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.430735e-01 0.844 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.547607e-01 0.810 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.547607e-01 0.810 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.169789e-01 0.932 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.169789e-01 0.932 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.341071e-01 0.873 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.341071e-01 0.873 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.341071e-01 0.873 0 0
Striated Muscle Contraction R-HSA-390522 1.430333e-01 0.845 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.430333e-01 0.845 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.430333e-01 0.845 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.615543e-01 0.792 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 1.171224e-01 0.931 0 0
Integrin signaling R-HSA-354192 1.341071e-01 0.873 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.667335e-01 0.778 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 1.735979e-01 0.760 0 0
PI3K/AKT activation R-HSA-198203 1.388094e-01 0.858 0 0
Chromosome Maintenance R-HSA-73886 1.448638e-01 0.839 0 0
Formation of the posterior neural plate R-HSA-9832991 1.560166e-01 0.807 0 0
Signaling by WNT in cancer R-HSA-4791275 1.254187e-01 0.902 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.341071e-01 0.873 0 0
PTEN Regulation R-HSA-6807070 1.645376e-01 0.784 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.506722e-01 0.822 0 0
Receptor Mediated Mitophagy R-HSA-8934903 1.388094e-01 0.858 0 0
ERK/MAPK targets R-HSA-198753 1.430735e-01 0.844 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.206584e-01 0.918 0 0
Cellular response to heat stress R-HSA-3371556 1.448638e-01 0.839 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 1.394403e-01 0.856 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.220609e-01 0.913 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 1.220609e-01 0.913 0 0
Ionotropic activity of kainate receptors R-HSA-451306 1.560166e-01 0.807 0 0
Notch-HLH transcription pathway R-HSA-350054 1.667335e-01 0.778 0 0
snRNP Assembly R-HSA-191859 1.232265e-01 0.909 0 0
Metabolism of non-coding RNA R-HSA-194441 1.232265e-01 0.909 0 0
Metabolism of RNA R-HSA-8953854 1.164160e-01 0.934 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 1.356084e-01 0.868 0 0
Signal attenuation R-HSA-74749 1.388094e-01 0.858 0 0
tRNA processing in the nucleus R-HSA-6784531 1.424432e-01 0.846 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 1.356084e-01 0.868 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 1.496107e-01 0.825 0 0
Signal amplification R-HSA-392518 1.521862e-01 0.818 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 1.496107e-01 0.825 0 0
NGF-stimulated transcription R-HSA-9031628 1.524591e-01 0.817 0 0
Mitochondrial calcium ion transport R-HSA-8949215 1.547607e-01 0.810 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.430333e-01 0.845 0 0
HCMV Late Events R-HSA-9610379 1.731524e-01 0.762 0 0
Vesicle-mediated transport R-HSA-5653656 1.330269e-01 0.876 0 0
Gastrulation R-HSA-9758941 1.384209e-01 0.859 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 1.735979e-01 0.760 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 1.343675e-01 0.872 0 0
MAP kinase activation R-HSA-450294 1.358903e-01 0.867 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 1.526444e-01 0.816 0 0
Nuclear import of Rev protein R-HSA-180746 1.521862e-01 0.818 0 0
Activation of RAC1 R-HSA-428540 1.735979e-01 0.760 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.547607e-01 0.810 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.268371e-01 0.897 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 1.578670e-01 0.802 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.631750e-01 0.787 0 0
NOD1/2 Signaling Pathway R-HSA-168638 1.521862e-01 0.818 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.631750e-01 0.787 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.375044e-01 0.862 0 0
Amyloid fiber formation R-HSA-977225 1.626484e-01 0.789 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.332725e-01 0.875 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.560166e-01 0.807 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.220609e-01 0.913 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.388094e-01 0.858 0 0
Signaling by Leptin R-HSA-2586552 1.388094e-01 0.858 0 0
Toll-like Receptor Cascades R-HSA-168898 1.742071e-01 0.759 0 0
HSF1-dependent transactivation R-HSA-3371571 1.766029e-01 0.753 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.784215e-01 0.749 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.789663e-01 0.747 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.795968e-01 0.746 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 1.795968e-01 0.746 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.808894e-01 0.743 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.814625e-01 0.741 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.814625e-01 0.741 0 0
Signalling to ERK5 R-HSA-198765 1.814625e-01 0.741 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.814625e-01 0.741 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 1.814625e-01 0.741 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.814625e-01 0.741 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.814625e-01 0.741 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.814625e-01 0.741 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.814625e-01 0.741 0 0
Potassium transport channels R-HSA-1296067 1.814625e-01 0.741 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.814625e-01 0.741 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.814625e-01 0.741 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.814625e-01 0.741 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.814625e-01 0.741 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.820833e-01 0.740 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.846176e-01 0.734 0 0
Regulated Necrosis R-HSA-5218859 1.846176e-01 0.734 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.914758e-01 0.718 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 1.914758e-01 0.718 0 0
Smooth Muscle Contraction R-HSA-445355 1.934497e-01 0.713 0 0
Glycolysis R-HSA-70171 1.968352e-01 0.706 0 0
Interleukin-17 signaling R-HSA-448424 1.996629e-01 0.700 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.996629e-01 0.700 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.009435e-01 0.697 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.009435e-01 0.697 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.025893e-01 0.693 0 0
TGFBR3 expression R-HSA-9839394 2.041117e-01 0.690 0 0
Long-term potentiation R-HSA-9620244 2.041117e-01 0.690 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 2.214350e-01 0.655 0 0
Classical Kir channels R-HSA-1296053 2.214350e-01 0.655 0 0
Invadopodia formation R-HSA-8941237 2.214350e-01 0.655 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 2.214350e-01 0.655 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 2.214350e-01 0.655 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 2.214350e-01 0.655 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 2.594578e-01 0.586 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.594578e-01 0.586 0 0
Signaling by MAP2K mutants R-HSA-9652169 2.594578e-01 0.586 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 2.594578e-01 0.586 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.956259e-01 0.529 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.956259e-01 0.529 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 2.956259e-01 0.529 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 3.300296e-01 0.481 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 3.300296e-01 0.481 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 3.300296e-01 0.481 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 3.300296e-01 0.481 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.300296e-01 0.481 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 2.095798e-01 0.679 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 2.095798e-01 0.679 0 0
cGMP effects R-HSA-418457 2.278450e-01 0.642 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 2.278450e-01 0.642 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.627549e-01 0.440 0 0
Erythropoietin activates STAT5 R-HSA-9027283 3.627549e-01 0.440 0 0
STAT5 Activation R-HSA-9645135 3.627549e-01 0.440 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 3.627549e-01 0.440 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 3.627549e-01 0.440 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.462128e-01 0.609 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.646297e-01 0.577 0 0
Phase 4 - resting membrane potential R-HSA-5576886 2.646297e-01 0.577 0 0
Phosphorylation of the APC/C R-HSA-176412 2.646297e-01 0.577 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.938837e-01 0.405 0 0
Netrin mediated repulsion signals R-HSA-418886 3.938837e-01 0.405 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 3.938837e-01 0.405 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 3.938837e-01 0.405 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 3.938837e-01 0.405 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 3.938837e-01 0.405 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.938837e-01 0.405 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 2.830471e-01 0.548 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.830471e-01 0.548 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 2.830471e-01 0.548 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 3.014212e-01 0.521 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.014212e-01 0.521 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.197123e-01 0.495 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 3.197123e-01 0.495 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 3.378848e-01 0.471 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 3.378848e-01 0.471 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 3.559066e-01 0.449 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 3.737492e-01 0.427 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.230306e-01 0.652 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.864260e-01 0.543 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 3.913872e-01 0.407 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 3.913872e-01 0.407 0 0
Dual Incision in GG-NER R-HSA-5696400 3.374576e-01 0.472 0 0
Centrosome maturation R-HSA-380287 2.390854e-01 0.621 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.845527e-01 0.546 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.845527e-01 0.546 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 3.645166e-01 0.438 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.134027e-01 0.504 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.647121e-01 0.438 0 0
Translation initiation complex formation R-HSA-72649 3.759364e-01 0.425 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 3.871426e-01 0.412 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 3.983222e-01 0.400 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 3.983222e-01 0.400 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 3.937772e-01 0.405 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.095798e-01 0.679 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.761586e-01 0.425 0 0
RNA Polymerase III Transcription R-HSA-74158 3.645166e-01 0.438 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 3.799318e-01 0.420 0 0
G0 and Early G1 R-HSA-1538133 2.967898e-01 0.528 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 2.300017e-01 0.638 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.559066e-01 0.449 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 4.087980e-01 0.388 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 2.830471e-01 0.548 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.754043e-01 0.560 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.975094e-01 0.526 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.469718e-01 0.607 0 0
Regulation of gap junction activity R-HSA-191650 2.594578e-01 0.586 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 3.621878e-01 0.441 0 0
Regulation of mitotic cell cycle R-HSA-453276 3.621878e-01 0.441 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 2.564500e-01 0.591 0 0
Regulation of TP53 Activity R-HSA-5633007 2.826092e-01 0.549 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 2.956259e-01 0.529 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.462128e-01 0.609 0 0
Killing mechanisms R-HSA-9664420 2.646297e-01 0.577 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 2.646297e-01 0.577 0 0
mRNA Editing: C to U Conversion R-HSA-72200 3.938837e-01 0.405 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 3.014212e-01 0.521 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.103339e-01 0.508 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.025822e-01 0.395 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.095561e-01 0.679 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.095798e-01 0.679 0 0
DNA Double Strand Break Response R-HSA-5693606 3.231078e-01 0.491 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.151412e-01 0.667 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 2.594578e-01 0.586 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 2.594578e-01 0.586 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.956259e-01 0.529 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 2.462128e-01 0.609 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 3.014212e-01 0.521 0 0
Attenuation phase R-HSA-3371568 2.112100e-01 0.675 0 0
Nuclear RNA decay R-HSA-9930044 3.103339e-01 0.508 0 0
Mismatch Repair R-HSA-5358508 3.197123e-01 0.495 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 3.238957e-01 0.490 0 0
Nucleotide Excision Repair R-HSA-5696398 3.705242e-01 0.431 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.161502e-01 0.665 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 3.014212e-01 0.521 0 0
S Phase R-HSA-69242 3.218874e-01 0.492 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 2.594578e-01 0.586 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.956259e-01 0.529 0 0
Formation of the Editosome R-HSA-75094 3.300296e-01 0.481 0 0
Sensory perception of salty taste R-HSA-9730628 3.300296e-01 0.481 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 3.627549e-01 0.440 0 0
G2/M DNA replication checkpoint R-HSA-69478 3.627549e-01 0.440 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 2.646297e-01 0.577 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 2.646297e-01 0.577 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 2.646297e-01 0.577 0 0
Trafficking of AMPA receptors R-HSA-399719 2.832815e-01 0.548 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.103339e-01 0.508 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 2.754043e-01 0.560 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.310137e-01 0.636 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 4.087980e-01 0.388 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.645166e-01 0.438 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.645166e-01 0.438 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 3.945961e-01 0.404 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.103339e-01 0.508 0 0
Signaling by VEGF R-HSA-194138 2.713050e-01 0.567 0 0
DNA Replication R-HSA-69306 2.423265e-01 0.616 0 0
Atorvastatin ADME R-HSA-9754706 2.646297e-01 0.577 0 0
ESR-mediated signaling R-HSA-8939211 2.229570e-01 0.652 0 0
Ion homeostasis R-HSA-5578775 2.197061e-01 0.658 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 3.617755e-01 0.442 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 2.594578e-01 0.586 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.938837e-01 0.405 0 0
Intra-Golgi traffic R-HSA-6811438 2.321615e-01 0.634 0 0
Signaling by TGFBR3 R-HSA-9839373 2.864260e-01 0.543 0 0
Homology Directed Repair R-HSA-5693538 2.205905e-01 0.656 0 0
mTORC1-mediated signalling R-HSA-166208 4.087980e-01 0.388 0 0
Activation of BH3-only proteins R-HSA-114452 2.698283e-01 0.569 0 0
DNA Repair R-HSA-73894 2.057933e-01 0.687 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.750481e-01 0.561 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 3.675358e-01 0.435 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 2.169755e-01 0.664 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 2.214350e-01 0.655 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 2.214350e-01 0.655 0 0
NADE modulates death signalling R-HSA-205025 2.594578e-01 0.586 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 2.956259e-01 0.529 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.300296e-01 0.481 0 0
Abacavir transmembrane transport R-HSA-2161517 3.627549e-01 0.440 0 0
VLDL clearance R-HSA-8964046 3.938837e-01 0.405 0 0
Disorders of Developmental Biology R-HSA-9675151 2.830471e-01 0.548 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 3.374576e-01 0.472 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 3.510032e-01 0.455 0 0
Sensory processing of sound R-HSA-9659379 2.721574e-01 0.565 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.772477e-01 0.557 0 0
Platelet homeostasis R-HSA-418346 2.426678e-01 0.615 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.627549e-01 0.440 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 3.742723e-01 0.427 0 0
Transmission across Chemical Synapses R-HSA-112315 3.595699e-01 0.444 0 0
FLT3 Signaling R-HSA-9607240 2.216200e-01 0.654 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 2.214350e-01 0.655 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 2.214350e-01 0.655 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 3.300296e-01 0.481 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 2.095798e-01 0.679 0 0
Formation of axial mesoderm R-HSA-9796292 2.095798e-01 0.679 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.938837e-01 0.405 0 0
Regulation of PTEN localization R-HSA-8948747 3.938837e-01 0.405 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 3.938837e-01 0.405 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 3.938837e-01 0.405 0 0
Platelet calcium homeostasis R-HSA-418360 2.564500e-01 0.591 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.112100e-01 0.675 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 2.216200e-01 0.654 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 4.087980e-01 0.388 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 4.047196e-01 0.393 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 3.983222e-01 0.400 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 3.737492e-01 0.427 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 2.698283e-01 0.569 0 0
Glucose metabolism R-HSA-70326 2.145220e-01 0.669 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.967898e-01 0.528 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.103339e-01 0.508 0 0
Signaling by NOTCH3 R-HSA-9012852 2.108321e-01 0.676 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.564500e-01 0.591 0 0
STING mediated induction of host immune responses R-HSA-1834941 3.378848e-01 0.471 0 0
Co-stimulation by CD28 R-HSA-389356 3.086436e-01 0.511 0 0
Signaling by NTRKs R-HSA-166520 2.149617e-01 0.668 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.956259e-01 0.529 0 0
Nef and signal transduction R-HSA-164944 3.627549e-01 0.440 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.462128e-01 0.609 0 0
CHL1 interactions R-HSA-447041 3.938837e-01 0.405 0 0
Synthesis of PG R-HSA-1483148 2.830471e-01 0.548 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.864260e-01 0.543 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 4.087980e-01 0.388 0 0
CREB3 factors activate genes R-HSA-8874211 3.627549e-01 0.440 0 0
Hemostasis R-HSA-109582 2.440991e-01 0.612 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 3.173523e-01 0.498 0 0
Signal transduction by L1 R-HSA-445144 3.559066e-01 0.449 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.103339e-01 0.508 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.983222e-01 0.400 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.086436e-01 0.511 0 0
Hedgehog 'off' state R-HSA-5610787 3.225183e-01 0.491 0 0
Influenza Infection R-HSA-168255 4.056872e-01 0.392 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 2.956259e-01 0.529 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 3.300296e-01 0.481 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 3.913885e-01 0.407 0 0
Synaptic adhesion-like molecules R-HSA-8849932 3.197123e-01 0.495 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.103339e-01 0.508 0 0
Platelet sensitization by LDL R-HSA-432142 3.197123e-01 0.495 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 2.941181e-01 0.531 0 0
Uptake and function of anthrax toxins R-HSA-5210891 3.014212e-01 0.521 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 2.095798e-01 0.679 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 3.014212e-01 0.521 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.197123e-01 0.495 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 2.278450e-01 0.642 0 0
SARS-CoV-1 Infection R-HSA-9678108 3.805388e-01 0.420 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 3.378848e-01 0.471 0 0
Regulation of CDH1 Function R-HSA-9764561 4.094669e-01 0.388 0 0
Nuclear Envelope Breakdown R-HSA-2980766 4.094669e-01 0.388 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 4.097446e-01 0.387 0 0
G2/M Checkpoints R-HSA-69481 4.173690e-01 0.379 0 0
Platelet degranulation R-HSA-114608 4.173690e-01 0.379 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 4.179639e-01 0.379 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.205688e-01 0.376 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 4.234936e-01 0.373 0 0
RSK activation R-HSA-444257 4.234936e-01 0.373 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 4.234936e-01 0.373 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 4.234936e-01 0.373 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 4.234936e-01 0.373 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 4.234936e-01 0.373 0 0
FGFR1b ligand binding and activation R-HSA-190370 4.234936e-01 0.373 0 0
MET receptor recycling R-HSA-8875656 4.234936e-01 0.373 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 4.234936e-01 0.373 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 4.234936e-01 0.373 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 4.234936e-01 0.373 0 0
Adrenoceptors R-HSA-390696 4.234936e-01 0.373 0 0
Interleukin receptor SHC signaling R-HSA-912526 4.259617e-01 0.371 0 0
Biosynthesis of maresins R-HSA-9018682 4.259617e-01 0.371 0 0
Growth hormone receptor signaling R-HSA-982772 4.259617e-01 0.371 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 4.269618e-01 0.370 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 4.269618e-01 0.370 0 0
Nuclear Receptor transcription pathway R-HSA-383280 4.305965e-01 0.366 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 4.311099e-01 0.365 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.311099e-01 0.365 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 4.311099e-01 0.365 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 4.397900e-01 0.357 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.428609e-01 0.354 0 0
Deadenylation of mRNA R-HSA-429947 4.428609e-01 0.354 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 4.428609e-01 0.354 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.428609e-01 0.354 0 0
TNFs bind their physiological receptors R-HSA-5669034 4.428609e-01 0.354 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 4.428609e-01 0.354 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 4.430189e-01 0.354 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 4.430189e-01 0.354 0 0
Signaling by FGFR1 in disease R-HSA-5655302 4.441467e-01 0.352 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 4.441467e-01 0.352 0 0
Developmental Cell Lineages R-HSA-9734767 4.471921e-01 0.350 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 4.499190e-01 0.347 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.516587e-01 0.345 0 0
Lipophagy R-HSA-9613354 4.516587e-01 0.345 0 0
ALK mutants bind TKIs R-HSA-9700645 4.516587e-01 0.345 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 4.516587e-01 0.345 0 0
Unwinding of DNA R-HSA-176974 4.516587e-01 0.345 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.516587e-01 0.345 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 4.516587e-01 0.345 0 0
mRNA Editing R-HSA-75072 4.516587e-01 0.345 0 0
Interleukin-1 processing R-HSA-448706 4.516587e-01 0.345 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 4.516587e-01 0.345 0 0
Viral Messenger RNA Synthesis R-HSA-168325 4.535431e-01 0.343 0 0
Cardiac conduction R-HSA-5576891 4.546771e-01 0.342 0 0
MTOR signalling R-HSA-165159 4.570641e-01 0.340 0 0
Tight junction interactions R-HSA-420029 4.594806e-01 0.338 0 0
Formation of the nephric duct R-HSA-9830364 4.594806e-01 0.338 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.594806e-01 0.338 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.594806e-01 0.338 0 0
Acyl chain remodelling of PS R-HSA-1482801 4.594806e-01 0.338 0 0
Interleukin-7 signaling R-HSA-1266695 4.594806e-01 0.338 0 0
Processing of DNA double-strand break ends R-HSA-5693607 4.595168e-01 0.338 0 0
Interferon Signaling R-HSA-913531 4.608073e-01 0.336 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 4.623092e-01 0.335 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 4.694932e-01 0.328 0 0
Signaling by SCF-KIT R-HSA-1433557 4.698527e-01 0.328 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 4.733187e-01 0.325 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 4.751814e-01 0.323 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 4.758077e-01 0.323 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.758077e-01 0.323 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.758077e-01 0.323 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 4.758077e-01 0.323 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.758077e-01 0.323 0 0
MAPK3 (ERK1) activation R-HSA-110056 4.784494e-01 0.320 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.784494e-01 0.320 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 4.784494e-01 0.320 0 0
Regulation of the apoptosome activity R-HSA-9627069 4.784494e-01 0.320 0 0
Formation of apoptosome R-HSA-111458 4.784494e-01 0.320 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.784494e-01 0.320 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.784494e-01 0.320 0 0
Formation of intermediate mesoderm R-HSA-9761174 4.784494e-01 0.320 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 4.784494e-01 0.320 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 4.784494e-01 0.320 0 0
Maturation of spike protein R-HSA-9683686 4.784494e-01 0.320 0 0
Pexophagy R-HSA-9664873 4.784494e-01 0.320 0 0
Cyclin D associated events in G1 R-HSA-69231 4.825038e-01 0.316 0 0
G1 Phase R-HSA-69236 4.825038e-01 0.316 0 0
Amine ligand-binding receptors R-HSA-375280 4.825038e-01 0.316 0 0
Ion transport by P-type ATPases R-HSA-936837 4.858784e-01 0.313 0 0
Viral Infection Pathways R-HSA-9824446 4.900293e-01 0.310 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 4.918312e-01 0.308 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 4.918312e-01 0.308 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 4.918312e-01 0.308 0 0
Cellular response to hypoxia R-HSA-1234174 4.964863e-01 0.304 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 4.964863e-01 0.304 0 0
PI Metabolism R-HSA-1483255 4.979972e-01 0.303 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 5.039328e-01 0.298 0 0
Interleukin-2 signaling R-HSA-9020558 5.039328e-01 0.298 0 0
vRNA Synthesis R-HSA-192814 5.039328e-01 0.298 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 5.039328e-01 0.298 0 0
Bicarbonate transporters R-HSA-425381 5.039328e-01 0.298 0 0
Transport of RCbl within the body R-HSA-9758890 5.039328e-01 0.298 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 5.039328e-01 0.298 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 5.039328e-01 0.298 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 5.039328e-01 0.298 0 0
Prostanoid ligand receptors R-HSA-391908 5.039328e-01 0.298 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 5.039328e-01 0.298 0 0
Platelet activation, signaling and aggregation R-HSA-76002 5.056388e-01 0.296 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 5.066898e-01 0.295 0 0
Regulation of TNFR1 signaling R-HSA-5357905 5.073625e-01 0.295 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 5.073625e-01 0.295 0 0
HIV elongation arrest and recovery R-HSA-167287 5.075418e-01 0.295 0 0
Pausing and recovery of HIV elongation R-HSA-167290 5.075418e-01 0.295 0 0
Formation of the Early Elongation Complex R-HSA-113418 5.075418e-01 0.295 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 5.075418e-01 0.295 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 5.075418e-01 0.295 0 0
Prednisone ADME R-HSA-9757110 5.075418e-01 0.295 0 0
Cytokine Signaling in Immune system R-HSA-1280215 5.091300e-01 0.293 0 0
Response of endothelial cells to shear stress R-HSA-9860931 5.148404e-01 0.288 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 5.174141e-01 0.286 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 5.195559e-01 0.284 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 5.229318e-01 0.282 0 0
Late endosomal microautophagy R-HSA-9615710 5.229318e-01 0.282 0 0
Leishmania phagocytosis R-HSA-9664417 5.276862e-01 0.278 0 0
Parasite infection R-HSA-9664407 5.276862e-01 0.278 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 5.276862e-01 0.278 0 0
DS-GAG biosynthesis R-HSA-2022923 5.281724e-01 0.277 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.281724e-01 0.277 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 5.281724e-01 0.277 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 5.281724e-01 0.277 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 5.281724e-01 0.277 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 5.281724e-01 0.277 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.281724e-01 0.277 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 5.281724e-01 0.277 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.281724e-01 0.277 0 0
Gluconeogenesis R-HSA-70263 5.315838e-01 0.274 0 0
Peptide chain elongation R-HSA-156902 5.341938e-01 0.272 0 0
Co-inhibition by PD-1 R-HSA-389948 5.363038e-01 0.271 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 5.379263e-01 0.269 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.379951e-01 0.269 0 0
Activation of the pre-replicative complex R-HSA-68962 5.379951e-01 0.269 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 5.379951e-01 0.269 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 5.379951e-01 0.269 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 5.379951e-01 0.269 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 5.379951e-01 0.269 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.379951e-01 0.269 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 5.379951e-01 0.269 0 0
SARS-CoV-1-host interactions R-HSA-9692914 5.396869e-01 0.268 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.480157e-01 0.261 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 5.480157e-01 0.261 0 0
Late Phase of HIV Life Cycle R-HSA-162599 5.489200e-01 0.260 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 5.512291e-01 0.259 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.512291e-01 0.259 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 5.512291e-01 0.259 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 5.512291e-01 0.259 0 0
IRAK1 recruits IKK complex R-HSA-937039 5.512291e-01 0.259 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 5.512291e-01 0.259 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.512291e-01 0.259 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.512291e-01 0.259 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 5.512291e-01 0.259 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 5.512291e-01 0.259 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 5.512291e-01 0.259 0 0
Signaling by LTK R-HSA-9842663 5.512291e-01 0.259 0 0
Repression of WNT target genes R-HSA-4641265 5.512291e-01 0.259 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 5.512291e-01 0.259 0 0
Polymerase switching R-HSA-69091 5.512291e-01 0.259 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 5.512291e-01 0.259 0 0
Leading Strand Synthesis R-HSA-69109 5.512291e-01 0.259 0 0
VLDLR internalisation and degradation R-HSA-8866427 5.512291e-01 0.259 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 5.512291e-01 0.259 0 0
Disorders of Nervous System Development R-HSA-9697154 5.512291e-01 0.259 0 0
Pervasive developmental disorders R-HSA-9005895 5.512291e-01 0.259 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.512291e-01 0.259 0 0
OAS antiviral response R-HSA-8983711 5.512291e-01 0.259 0 0
Interleukin-15 signaling R-HSA-8983432 5.512291e-01 0.259 0 0
EGFR downregulation R-HSA-182971 5.527267e-01 0.257 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 5.527267e-01 0.257 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 5.527267e-01 0.257 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.527267e-01 0.257 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 5.527267e-01 0.257 0 0
PI3K Cascade R-HSA-109704 5.551215e-01 0.256 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 5.559414e-01 0.255 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 5.559414e-01 0.255 0 0
Stimuli-sensing channels R-HSA-2672351 5.559414e-01 0.255 0 0
G alpha (q) signalling events R-HSA-416476 5.592820e-01 0.252 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 5.609814e-01 0.251 0 0
DNA strand elongation R-HSA-69190 5.671233e-01 0.246 0 0
Inwardly rectifying K+ channels R-HSA-1296065 5.671233e-01 0.246 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 5.671233e-01 0.246 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 5.678426e-01 0.246 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 5.731603e-01 0.242 0 0
Processing of SMDT1 R-HSA-8949664 5.731603e-01 0.242 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 5.731603e-01 0.242 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 5.731603e-01 0.242 0 0
FGFR1c ligand binding and activation R-HSA-190373 5.731603e-01 0.242 0 0
Frs2-mediated activation R-HSA-170968 5.731603e-01 0.242 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 5.731603e-01 0.242 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.731603e-01 0.242 0 0
CD28 dependent Vav1 pathway R-HSA-389359 5.731603e-01 0.242 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 5.731603e-01 0.242 0 0
Maturation of nucleoprotein R-HSA-9683610 5.731603e-01 0.242 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 5.766059e-01 0.239 0 0
Switching of origins to a post-replicative state R-HSA-69052 5.775733e-01 0.238 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 5.779382e-01 0.238 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 5.779382e-01 0.238 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 5.779382e-01 0.238 0 0
Regulation of necroptotic cell death R-HSA-5675482 5.811823e-01 0.236 0 0
SARS-CoV-2-host interactions R-HSA-9705683 5.859507e-01 0.232 0 0
Signaling by NOTCH4 R-HSA-9013694 5.871781e-01 0.231 0 0
Inositol phosphate metabolism R-HSA-1483249 5.876224e-01 0.231 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 5.890669e-01 0.230 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 5.890669e-01 0.230 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 5.890669e-01 0.230 0 0
Ion channel transport R-HSA-983712 5.934166e-01 0.227 0 0
Removal of the Flap Intermediate R-HSA-69166 5.940211e-01 0.226 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 5.940211e-01 0.226 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 5.940211e-01 0.226 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.940211e-01 0.226 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 5.940211e-01 0.226 0 0
Retrograde neurotrophin signalling R-HSA-177504 5.940211e-01 0.226 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 5.940211e-01 0.226 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.940211e-01 0.226 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.940211e-01 0.226 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 5.940211e-01 0.226 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 5.940211e-01 0.226 0 0
Non-canonical inflammasome activation R-HSA-9686114 5.940211e-01 0.226 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 5.940211e-01 0.226 0 0
Signal regulatory protein family interactions R-HSA-391160 5.940211e-01 0.226 0 0
Zinc transporters R-HSA-435354 5.940211e-01 0.226 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 5.949023e-01 0.226 0 0
Miscellaneous transport and binding events R-HSA-5223345 5.949023e-01 0.226 0 0
Effects of PIP2 hydrolysis R-HSA-114508 5.949023e-01 0.226 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 5.954498e-01 0.225 0 0
Protein ubiquitination R-HSA-8852135 5.966544e-01 0.224 0 0
Adaptive Immune System R-HSA-1280218 5.990157e-01 0.223 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 6.000050e-01 0.222 0 0
MITF-M-dependent gene expression R-HSA-9856651 6.034870e-01 0.219 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 6.038278e-01 0.219 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 6.038278e-01 0.219 0 0
Interleukin-12 signaling R-HSA-9020591 6.059997e-01 0.218 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 6.082829e-01 0.216 0 0
Calnexin/calreticulin cycle R-HSA-901042 6.082829e-01 0.216 0 0
Formation of a pool of free 40S subunits R-HSA-72689 6.121062e-01 0.213 0 0
Eukaryotic Translation Termination R-HSA-72764 6.121062e-01 0.213 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 6.138635e-01 0.212 0 0
Erythropoietin activates RAS R-HSA-9027284 6.138635e-01 0.212 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.138635e-01 0.212 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 6.138635e-01 0.212 0 0
G beta:gamma signalling through BTK R-HSA-8964315 6.138635e-01 0.212 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.138635e-01 0.212 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 6.138635e-01 0.212 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.138635e-01 0.212 0 0
Biotin transport and metabolism R-HSA-196780 6.138635e-01 0.212 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 6.138635e-01 0.212 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 6.138635e-01 0.212 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 6.138635e-01 0.212 0 0
Protein methylation R-HSA-8876725 6.138635e-01 0.212 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 6.138635e-01 0.212 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 6.165989e-01 0.210 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 6.180938e-01 0.209 0 0
Signaling by Interleukins R-HSA-449147 6.195714e-01 0.208 0 0
Signaling by EGFR R-HSA-177929 6.213003e-01 0.207 0 0
TNF signaling R-HSA-75893 6.213003e-01 0.207 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 6.213245e-01 0.207 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 6.213245e-01 0.207 0 0
IRS-mediated signalling R-HSA-112399 6.316539e-01 0.200 0 0
Organelle biogenesis and maintenance R-HSA-1852241 6.321226e-01 0.199 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.327373e-01 0.199 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 6.327373e-01 0.199 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 6.327373e-01 0.199 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.327373e-01 0.199 0 0
Activation of SMO R-HSA-5635838 6.327373e-01 0.199 0 0
Prolonged ERK activation events R-HSA-169893 6.327373e-01 0.199 0 0
Fructose catabolism R-HSA-70350 6.327373e-01 0.199 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 6.327373e-01 0.199 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.327373e-01 0.199 0 0
Synthesis of wybutosine at G37 of tRNA(Phe) R-HSA-6782861 6.327373e-01 0.199 0 0
Negative regulation of FLT3 R-HSA-9706369 6.327373e-01 0.199 0 0
Cap-dependent Translation Initiation R-HSA-72737 6.328429e-01 0.199 0 0
Eukaryotic Translation Initiation R-HSA-72613 6.328429e-01 0.199 0 0
FLT3 signaling in disease R-HSA-9682385 6.340283e-01 0.198 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 6.340283e-01 0.198 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 6.418096e-01 0.193 0 0
Ovarian tumor domain proteases R-HSA-5689896 6.463961e-01 0.190 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 6.463961e-01 0.190 0 0
HIV Life Cycle R-HSA-162587 6.483481e-01 0.188 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 6.483691e-01 0.188 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 6.506896e-01 0.187 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 6.506896e-01 0.187 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 6.506896e-01 0.187 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.506896e-01 0.187 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 6.506896e-01 0.187 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.506896e-01 0.187 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 6.506896e-01 0.187 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.506896e-01 0.187 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.517664e-01 0.186 0 0
Signaling by Hedgehog R-HSA-5358351 6.573088e-01 0.182 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 6.584304e-01 0.181 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 6.584304e-01 0.181 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 6.584304e-01 0.181 0 0
Selenocysteine synthesis R-HSA-2408557 6.595930e-01 0.181 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 6.595930e-01 0.181 0 0
Signaling by ERBB2 R-HSA-1227986 6.615240e-01 0.179 0 0
SARS-CoV-2 Infection R-HSA-9694516 6.677093e-01 0.175 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.677655e-01 0.175 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 6.677655e-01 0.175 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 6.677655e-01 0.175 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 6.677655e-01 0.175 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 6.677655e-01 0.175 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.677655e-01 0.175 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.677655e-01 0.175 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 6.701343e-01 0.174 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 6.701343e-01 0.174 0 0
Plasma lipoprotein clearance R-HSA-8964043 6.701343e-01 0.174 0 0
Signaling by ALK R-HSA-201556 6.701343e-01 0.174 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 6.710820e-01 0.173 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 6.710820e-01 0.173 0 0
Viral mRNA Translation R-HSA-192823 6.745604e-01 0.171 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 6.804405e-01 0.167 0 0
NCAM signaling for neurite out-growth R-HSA-375165 6.804405e-01 0.167 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 6.815112e-01 0.167 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 6.815112e-01 0.167 0 0
HIV Transcription Elongation R-HSA-167169 6.815112e-01 0.167 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 6.815112e-01 0.167 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 6.815112e-01 0.167 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 6.815112e-01 0.167 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 6.815112e-01 0.167 0 0
Diseases of Immune System R-HSA-5260271 6.815112e-01 0.167 0 0
Interleukin-2 family signaling R-HSA-451927 6.815112e-01 0.167 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 6.818785e-01 0.166 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 6.818785e-01 0.166 0 0
Protein-protein interactions at synapses R-HSA-6794362 6.839286e-01 0.165 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.839286e-01 0.165 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.840076e-01 0.165 0 0
GAB1 signalosome R-HSA-180292 6.840076e-01 0.165 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.840076e-01 0.165 0 0
Chaperone Mediated Autophagy R-HSA-9613829 6.840076e-01 0.165 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 6.840076e-01 0.165 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.840076e-01 0.165 0 0
FGFR1 ligand binding and activation R-HSA-190242 6.840076e-01 0.165 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 6.840076e-01 0.165 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.840076e-01 0.165 0 0
Tie2 Signaling R-HSA-210993 6.840076e-01 0.165 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 6.840076e-01 0.165 0 0
Host Interactions of HIV factors R-HSA-162909 6.883702e-01 0.162 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 6.895998e-01 0.161 0 0
Maturation of spike protein R-HSA-9694548 6.925652e-01 0.160 0 0
IGF1R signaling cascade R-HSA-2428924 6.985606e-01 0.156 0 0
Insulin receptor signalling cascade R-HSA-74751 6.985606e-01 0.156 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.994565e-01 0.155 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 6.994565e-01 0.155 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.994565e-01 0.155 0 0
Maturation of nucleoprotein R-HSA-9694631 6.994565e-01 0.155 0 0
Other interleukin signaling R-HSA-449836 6.994565e-01 0.155 0 0
The NLRP3 inflammasome R-HSA-844456 6.994565e-01 0.155 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 6.996895e-01 0.155 0 0
XBP1(S) activates chaperone genes R-HSA-381038 6.996895e-01 0.155 0 0
G1/S Transition R-HSA-69206 7.013518e-01 0.154 0 0
Translation of Structural Proteins R-HSA-9683701 7.033007e-01 0.153 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 7.073237e-01 0.150 0 0
Interleukin-12 family signaling R-HSA-447115 7.073551e-01 0.150 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 7.100343e-01 0.149 0 0
Synthesis of DNA R-HSA-69239 7.100343e-01 0.149 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 7.137223e-01 0.146 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 7.137223e-01 0.146 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 7.137223e-01 0.146 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 7.141511e-01 0.146 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 7.141511e-01 0.146 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 7.141511e-01 0.146 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 7.141511e-01 0.146 0 0
Nephrin family interactions R-HSA-373753 7.141511e-01 0.146 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 7.141511e-01 0.146 0 0
rRNA processing R-HSA-72312 7.155662e-01 0.145 0 0
Neuronal System R-HSA-112316 7.225525e-01 0.141 0 0
Kidney development R-HSA-9830369 7.242612e-01 0.140 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.281281e-01 0.138 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 7.281281e-01 0.138 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 7.281281e-01 0.138 0 0
Lagging Strand Synthesis R-HSA-69186 7.281281e-01 0.138 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.281281e-01 0.138 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 7.281281e-01 0.138 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.281281e-01 0.138 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 7.281281e-01 0.138 0 0
tRNA processing R-HSA-72306 7.286862e-01 0.137 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 7.286999e-01 0.137 0 0
SARS-CoV Infections R-HSA-9679506 7.303393e-01 0.136 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 7.336443e-01 0.135 0 0
Potential therapeutics for SARS R-HSA-9679191 7.353615e-01 0.133 0 0
CS-GAG biosynthesis R-HSA-2022870 7.414224e-01 0.130 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.414224e-01 0.130 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.414224e-01 0.130 0 0
Eicosanoids R-HSA-211979 7.414224e-01 0.130 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 7.414224e-01 0.130 0 0
Miscellaneous substrates R-HSA-211958 7.414224e-01 0.130 0 0
Assembly Of The HIV Virion R-HSA-175474 7.414224e-01 0.130 0 0
Glutathione synthesis and recycling R-HSA-174403 7.414224e-01 0.130 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 7.414224e-01 0.130 0 0
Signaling by PDGFR in disease R-HSA-9671555 7.414224e-01 0.130 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 7.431554e-01 0.129 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 7.431554e-01 0.129 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 7.431554e-01 0.129 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 7.431554e-01 0.129 0 0
IRE1alpha activates chaperones R-HSA-381070 7.435428e-01 0.129 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 7.523742e-01 0.124 0 0
Diseases of DNA repair R-HSA-9675135 7.523742e-01 0.124 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 7.540674e-01 0.123 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.540674e-01 0.123 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.540674e-01 0.123 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 7.540674e-01 0.123 0 0
Fructose metabolism R-HSA-5652084 7.540674e-01 0.123 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 7.540674e-01 0.123 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.540674e-01 0.123 0 0
LDL clearance R-HSA-8964038 7.540674e-01 0.123 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 7.558243e-01 0.122 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 7.613064e-01 0.118 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 7.632442e-01 0.117 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 7.660948e-01 0.116 0 0
Fatty acids R-HSA-211935 7.660948e-01 0.116 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.660948e-01 0.116 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.660948e-01 0.116 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 7.660948e-01 0.116 0 0
Formation of the ureteric bud R-HSA-9830674 7.660948e-01 0.116 0 0
Syndecan interactions R-HSA-3000170 7.660948e-01 0.116 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 7.660948e-01 0.116 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.660948e-01 0.116 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 7.775344e-01 0.109 0 0
Signaling by FGFR in disease R-HSA-1226099 7.775344e-01 0.109 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 7.775347e-01 0.109 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 7.775347e-01 0.109 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 7.775347e-01 0.109 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.775347e-01 0.109 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 7.783352e-01 0.109 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 7.783352e-01 0.109 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 7.783352e-01 0.109 0 0
Immune System R-HSA-168256 7.786969e-01 0.109 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 7.844095e-01 0.105 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 7.844095e-01 0.105 0 0
Signaling by TGFB family members R-HSA-9006936 7.863576e-01 0.104 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.864439e-01 0.104 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 7.883403e-01 0.103 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 7.883403e-01 0.103 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 7.884157e-01 0.103 0 0
G protein gated Potassium channels R-HSA-1296059 7.884157e-01 0.103 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 7.884157e-01 0.103 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 7.884157e-01 0.103 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.884157e-01 0.103 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 7.884157e-01 0.103 0 0
Laminin interactions R-HSA-3000157 7.884157e-01 0.103 0 0
Unfolded Protein Response (UPR) R-HSA-381119 7.919021e-01 0.101 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.945181e-01 0.100 0 0
Translation of Structural Proteins R-HSA-9694635 7.976324e-01 0.098 0 0
MET activates PTK2 signaling R-HSA-8874081 7.987652e-01 0.098 0 0
Signaling by EGFR in Cancer R-HSA-1643713 7.987652e-01 0.098 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.987652e-01 0.098 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 7.987652e-01 0.098 0 0
Abacavir ADME R-HSA-2161522 7.987652e-01 0.098 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 7.987652e-01 0.098 0 0
Neurexins and neuroligins R-HSA-6794361 8.018812e-01 0.096 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.018812e-01 0.096 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.018812e-01 0.096 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 8.048483e-01 0.094 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.086090e-01 0.092 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.086090e-01 0.092 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 8.086090e-01 0.092 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 8.086090e-01 0.092 0 0
Triglyceride biosynthesis R-HSA-75109 8.086090e-01 0.092 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 8.086090e-01 0.092 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 8.086090e-01 0.092 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.101703e-01 0.091 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 8.109066e-01 0.091 0 0
Interleukin-1 signaling R-HSA-9020702 8.109973e-01 0.091 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 8.163197e-01 0.088 0 0
SLC transporter disorders R-HSA-5619102 8.174351e-01 0.088 0 0
Telomere Extension By Telomerase R-HSA-171319 8.179718e-01 0.087 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 8.179718e-01 0.087 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 8.179718e-01 0.087 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.179718e-01 0.087 0 0
Pyrimidine salvage R-HSA-73614 8.179718e-01 0.087 0 0
Inflammasomes R-HSA-622312 8.179718e-01 0.087 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.253145e-01 0.083 0 0
Signaling by Erythropoietin R-HSA-9006335 8.268772e-01 0.083 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 8.268772e-01 0.083 0 0
mRNA Capping R-HSA-72086 8.268772e-01 0.083 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 8.268772e-01 0.083 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 8.268772e-01 0.083 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.268772e-01 0.083 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 8.268772e-01 0.083 0 0
DARPP-32 events R-HSA-180024 8.268772e-01 0.083 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 8.298094e-01 0.081 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.298094e-01 0.081 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 8.332819e-01 0.079 0 0
DAP12 signaling R-HSA-2424491 8.353474e-01 0.078 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.353474e-01 0.078 0 0
Neurotransmitter clearance R-HSA-112311 8.353474e-01 0.078 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.353474e-01 0.078 0 0
Synthesis of PA R-HSA-1483166 8.362139e-01 0.078 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 8.434037e-01 0.074 0 0
Budding and maturation of HIV virion R-HSA-162588 8.434037e-01 0.074 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 8.434037e-01 0.074 0 0
Downstream signal transduction R-HSA-186763 8.434037e-01 0.074 0 0
Extension of Telomeres R-HSA-180786 8.483729e-01 0.071 0 0
Peroxisomal protein import R-HSA-9033241 8.483729e-01 0.071 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.483729e-01 0.071 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 8.486796e-01 0.071 0 0
Interleukin-1 family signaling R-HSA-446652 8.524697e-01 0.069 0 0
Glutathione conjugation R-HSA-156590 8.541394e-01 0.068 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.541394e-01 0.068 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 8.583543e-01 0.066 0 0
G-protein beta:gamma signalling R-HSA-397795 8.583543e-01 0.066 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 8.583543e-01 0.066 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 8.583543e-01 0.066 0 0
PPARA activates gene expression R-HSA-1989781 8.633759e-01 0.064 0 0
Heme signaling R-HSA-9707616 8.650760e-01 0.063 0 0
CS/DS degradation R-HSA-2024101 8.652861e-01 0.063 0 0
Resolution of D-Loop Structures R-HSA-5693537 8.652861e-01 0.063 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.652861e-01 0.063 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 8.652861e-01 0.063 0 0
HIV Infection R-HSA-162906 8.692955e-01 0.061 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.702697e-01 0.060 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 8.718791e-01 0.060 0 0
eNOS activation R-HSA-203615 8.718791e-01 0.060 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.718791e-01 0.060 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 8.718791e-01 0.060 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 8.718791e-01 0.060 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.718791e-01 0.060 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 8.718791e-01 0.060 0 0
Signaling by NOTCH2 R-HSA-1980145 8.718791e-01 0.060 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.718791e-01 0.060 0 0
Cellular response to starvation R-HSA-9711097 8.736065e-01 0.059 0 0
Regulation of Apoptosis R-HSA-169911 8.781498e-01 0.056 0 0
Signalling to ERKs R-HSA-187687 8.781498e-01 0.056 0 0
PERK regulates gene expression R-HSA-381042 8.781498e-01 0.056 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 8.781498e-01 0.056 0 0
Integration of energy metabolism R-HSA-163685 8.802252e-01 0.055 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.835675e-01 0.054 0 0
RUNX2 regulates bone development R-HSA-8941326 8.841140e-01 0.053 0 0
HSF1 activation R-HSA-3371511 8.841140e-01 0.053 0 0
G1/S-Specific Transcription R-HSA-69205 8.841140e-01 0.053 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 8.847234e-01 0.053 0 0
Signaling by Insulin receptor R-HSA-74752 8.847261e-01 0.053 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.847261e-01 0.053 0 0
Interferon alpha/beta signaling R-HSA-909733 8.861204e-01 0.053 0 0
Ribosome-associated quality control R-HSA-9948299 8.868296e-01 0.052 0 0
Leishmania infection R-HSA-9658195 8.869663e-01 0.052 0 0
Parasitic Infection Pathways R-HSA-9824443 8.869663e-01 0.052 0 0
Degradation of DVL R-HSA-4641258 8.897866e-01 0.051 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.897866e-01 0.051 0 0
NCAM1 interactions R-HSA-419037 8.897866e-01 0.051 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 8.897866e-01 0.051 0 0
Collagen formation R-HSA-1474290 8.923924e-01 0.049 0 0
Transcription of the HIV genome R-HSA-167172 8.935221e-01 0.049 0 0
MET promotes cell motility R-HSA-8875878 8.951819e-01 0.048 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 8.951819e-01 0.048 0 0
Stabilization of p53 R-HSA-69541 9.003133e-01 0.046 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.003133e-01 0.046 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 9.016931e-01 0.045 0 0
Innate Immune System R-HSA-168249 9.019395e-01 0.045 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.030360e-01 0.044 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.051938e-01 0.043 0 0
Generation of second messenger molecules R-HSA-202433 9.051938e-01 0.043 0 0
Hedgehog 'on' state R-HSA-5632684 9.055556e-01 0.043 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.062709e-01 0.043 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.092760e-01 0.041 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.098357e-01 0.041 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.098357e-01 0.041 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.098357e-01 0.041 0 0
Cellular response to chemical stress R-HSA-9711123 9.108229e-01 0.041 0 0
Ca2+ pathway R-HSA-4086398 9.128588e-01 0.040 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.142505e-01 0.039 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.142505e-01 0.039 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.142505e-01 0.039 0 0
Signaling by ERBB4 R-HSA-1236394 9.163085e-01 0.038 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.163085e-01 0.038 0 0
Phospholipid metabolism R-HSA-1483257 9.163949e-01 0.038 0 0
Activation of GABAB receptors R-HSA-991365 9.184495e-01 0.037 0 0
GABA B receptor activation R-HSA-977444 9.184495e-01 0.037 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.184495e-01 0.037 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.184495e-01 0.037 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.196297e-01 0.036 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.262413e-01 0.033 0 0
DAP12 interactions R-HSA-2172127 9.262413e-01 0.033 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.262413e-01 0.033 0 0
Proteasome assembly R-HSA-9907900 9.262413e-01 0.033 0 0
PCP/CE pathway R-HSA-4086400 9.288642e-01 0.032 0 0
Cholesterol biosynthesis R-HSA-191273 9.288642e-01 0.032 0 0
Protein localization R-HSA-9609507 9.292468e-01 0.032 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.298537e-01 0.032 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.298537e-01 0.032 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.298537e-01 0.032 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.317130e-01 0.031 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.332895e-01 0.030 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.332895e-01 0.030 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.332895e-01 0.030 0 0
Signaling by MET R-HSA-6806834 9.344536e-01 0.029 0 0
Adipogenesis R-HSA-9843745 9.359234e-01 0.029 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.365571e-01 0.028 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.365571e-01 0.028 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.370899e-01 0.028 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.389765e-01 0.027 0 0
GPCR downstream signalling R-HSA-388396 9.390880e-01 0.027 0 0
Metal ion SLC transporters R-HSA-425410 9.396649e-01 0.027 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.420636e-01 0.026 0 0
DNA Damage Bypass R-HSA-73893 9.426206e-01 0.026 0 0
Degradation of CDH1 R-HSA-9766229 9.426206e-01 0.026 0 0
Neutrophil degranulation R-HSA-6798695 9.447226e-01 0.025 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.475001e-01 0.023 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.481052e-01 0.023 0 0
Complex IV assembly R-HSA-9864848 9.481052e-01 0.023 0 0
The phototransduction cascade R-HSA-2514856 9.481052e-01 0.023 0 0
Selenoamino acid metabolism R-HSA-2408522 9.495395e-01 0.022 0 0
Orc1 removal from chromatin R-HSA-68949 9.506479e-01 0.022 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.506479e-01 0.022 0 0
Signaling by GPCR R-HSA-372790 9.519305e-01 0.021 0 0
Pyruvate metabolism R-HSA-70268 9.529133e-01 0.021 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.530662e-01 0.021 0 0
Post-translational protein modification R-HSA-597592 9.565253e-01 0.019 0 0
ER-Phagosome pathway R-HSA-1236974 9.566851e-01 0.019 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.575535e-01 0.019 0 0
Paracetamol ADME R-HSA-9753281 9.575535e-01 0.019 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.577492e-01 0.019 0 0
Neurotransmitter release cycle R-HSA-112310 9.584608e-01 0.018 0 0
Peptide hormone metabolism R-HSA-2980736 9.593019e-01 0.018 0 0
Signaling by FGFR1 R-HSA-5654736 9.596337e-01 0.018 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.633790e-01 0.016 0 0
Dual incision in TC-NER R-HSA-6782135 9.634938e-01 0.016 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.648905e-01 0.016 0 0
Triglyceride metabolism R-HSA-8979227 9.652832e-01 0.015 0 0
Regulation of beta-cell development R-HSA-186712 9.652832e-01 0.015 0 0
RAB geranylgeranylation R-HSA-8873719 9.669851e-01 0.015 0 0
GABA receptor activation R-HSA-977443 9.669851e-01 0.015 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.669851e-01 0.015 0 0
tRNA Aminoacylation R-HSA-379724 9.669851e-01 0.015 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.686036e-01 0.014 0 0
Nucleotide salvage R-HSA-8956321 9.686036e-01 0.014 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.690734e-01 0.014 0 0
Mitochondrial protein import R-HSA-1268020 9.701429e-01 0.013 0 0
Signaling by PDGF R-HSA-186797 9.701429e-01 0.013 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.703578e-01 0.013 0 0
Potassium Channels R-HSA-1296071 9.703578e-01 0.013 0 0
Infectious disease R-HSA-5663205 9.706527e-01 0.013 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.706780e-01 0.013 0 0
Disease R-HSA-1643685 9.715639e-01 0.013 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.716068e-01 0.013 0 0
Regulation of insulin secretion R-HSA-422356 9.727741e-01 0.012 0 0
Xenobiotics R-HSA-211981 9.729990e-01 0.012 0 0
Glycosphingolipid biosynthesis R-HSA-9840309 9.729990e-01 0.012 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.739099e-01 0.011 0 0
ABC-family proteins mediated transport R-HSA-382556 9.749998e-01 0.011 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.762635e-01 0.010 0 0
Nicotinate metabolism R-HSA-196807 9.767797e-01 0.010 0 0
Interferon gamma signaling R-HSA-877300 9.770911e-01 0.010 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.779185e-01 0.010 0 0
Circadian clock R-HSA-9909396 9.786721e-01 0.009 0 0
RSV-host interactions R-HSA-9833110 9.798216e-01 0.009 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.798740e-01 0.009 0 0
COPII-mediated vesicle transport R-HSA-204005 9.800316e-01 0.009 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.800316e-01 0.009 0 0
Metabolism of cofactors R-HSA-8978934 9.810111e-01 0.008 0 0
Retinoid metabolism and transport R-HSA-975634 9.810111e-01 0.008 0 0
Neddylation R-HSA-8951664 9.810894e-01 0.008 0 0
Aspirin ADME R-HSA-9749641 9.828285e-01 0.008 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.844260e-01 0.007 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.856532e-01 0.006 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.864563e-01 0.006 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.864563e-01 0.006 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.873031e-01 0.006 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.885150e-01 0.005 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.885189e-01 0.005 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.885189e-01 0.005 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.901281e-01 0.004 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.915120e-01 0.004 0 0
Formation of the cornified envelope R-HSA-6809371 9.922630e-01 0.003 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.949496e-01 0.002 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.950321e-01 0.002 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.953622e-01 0.002 0 0
Signaling by FGFR R-HSA-190236 9.958068e-01 0.002 0 0
Extracellular matrix organization R-HSA-1474244 9.964652e-01 0.002 0 0
Opioid Signalling R-HSA-111885 9.969011e-01 0.001 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.970535e-01 0.001 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.971096e-01 0.001 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.972231e-01 0.001 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.973452e-01 0.001 0 0
Visual phototransduction R-HSA-2187338 9.976809e-01 0.001 0 0
TCR signaling R-HSA-202403 9.978227e-01 0.001 0 0
Peptide ligand-binding receptors R-HSA-375276 9.978605e-01 0.001 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.980317e-01 0.001 0 0
Arachidonate metabolism R-HSA-2142753 9.981498e-01 0.001 0 0
Metabolism of steroids R-HSA-8957322 9.983607e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.984705e-01 0.001 0 0
Mitochondrial biogenesis R-HSA-1592230 9.986173e-01 0.001 0 0
Sphingolipid metabolism R-HSA-428157 9.988614e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.989371e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.989786e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.990648e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.993836e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.994718e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.997575e-01 0.000 0 0
Keratinization R-HSA-6805567 9.998592e-01 0.000 0 0
Translation R-HSA-72766 9.998833e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.998858e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.998867e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.999300e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999331e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999367e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999367e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999509e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999569e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.999619e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999638e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.999701e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999770e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999956e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.999964e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999977e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999978e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 9.999992e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
M Phase R-HSA-68886 1.110223e-16 15.955 1 0
Cell Cycle, Mitotic R-HSA-69278 1.110223e-16 15.955 1 0
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 1 0
Cellular responses to stress R-HSA-2262752 1.468270e-12 11.833 0 0
Cellular responses to stimuli R-HSA-8953897 3.208767e-12 11.494 0 0
Chromatin organization R-HSA-4839726 8.045231e-12 11.094 0 0
Chromatin modifying enzymes R-HSA-3247509 1.477185e-11 10.831 0 0
Mitotic Prometaphase R-HSA-68877 6.342016e-11 10.198 1 1
Mitotic Anaphase R-HSA-68882 8.542056e-11 10.068 1 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.031197e-10 9.987 1 0
Cellular Senescence R-HSA-2559583 1.662288e-10 9.779 0 0
Separation of Sister Chromatids R-HSA-2467813 1.868835e-10 9.728 1 1
Mitotic Prophase R-HSA-68875 3.608460e-10 9.443 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 4.631704e-10 9.334 1 1
Cell Cycle Checkpoints R-HSA-69620 9.840723e-10 9.007 1 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.401432e-09 8.620 1 1
Signaling by ALK fusions and activated point mutants R-HSA-9725370 4.078291e-09 8.390 0 0
Signaling by ALK in cancer R-HSA-9700206 4.078291e-09 8.390 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 4.709758e-09 8.327 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.361534e-08 7.866 0 0
Axon guidance R-HSA-422475 2.329216e-08 7.633 0 0
HATs acetylate histones R-HSA-3214847 7.192951e-08 7.143 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 8.916943e-08 7.050 0 0
Nervous system development R-HSA-9675108 9.789170e-08 7.009 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.440258e-07 6.842 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.540382e-07 6.812 0 0
Membrane Trafficking R-HSA-199991 2.366268e-07 6.626 0 0
Nuclear Envelope Breakdown R-HSA-2980766 5.337399e-07 6.273 0 0
Aggrephagy R-HSA-9646399 6.602797e-07 6.180 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 6.602797e-07 6.180 0 0
Deubiquitination R-HSA-5688426 8.005552e-07 6.097 0 0
Gene Silencing by RNA R-HSA-211000 1.310885e-06 5.882 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.566408e-06 5.805 1 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.810187e-06 5.742 0 0
Apoptotic execution phase R-HSA-75153 1.978668e-06 5.704 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.165356e-06 5.664 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.130872e-06 5.671 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.654728e-06 5.576 0 0
HDACs deacetylate histones R-HSA-3214815 2.843479e-06 5.546 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.891805e-06 5.539 0 0
HCMV Early Events R-HSA-9609690 3.309756e-06 5.480 0 0
Selective autophagy R-HSA-9663891 3.304439e-06 5.481 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 3.588252e-06 5.445 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.525597e-06 5.453 0 0
Nuclear import of Rev protein R-HSA-180746 3.588252e-06 5.445 0 0
Cell-Cell communication R-HSA-1500931 4.135508e-06 5.383 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.284859e-06 5.368 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.284859e-06 5.368 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 4.423483e-06 5.354 1 1
Amplification of signal from the kinetochores R-HSA-141424 4.423483e-06 5.354 1 0
Cellular response to heat stress R-HSA-3371556 4.746840e-06 5.324 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.910769e-06 5.309 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 5.085729e-06 5.294 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 6.319338e-06 5.199 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 6.367801e-06 5.196 0 0
ISG15 antiviral mechanism R-HSA-1169408 6.808381e-06 5.167 0 0
PRC2 methylates histones and DNA R-HSA-212300 7.127299e-06 5.147 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 7.766694e-06 5.110 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 7.528088e-06 5.123 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 7.929816e-06 5.101 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 8.230875e-06 5.085 0 0
Recycling pathway of L1 R-HSA-437239 8.401753e-06 5.076 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 8.951886e-06 5.048 0 0
Chaperone Mediated Autophagy R-HSA-9613829 9.292908e-06 5.032 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.114060e-05 4.953 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.114060e-05 4.953 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.140191e-05 4.943 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.268085e-05 4.897 0 0
Meiotic synapsis R-HSA-1221632 1.443311e-05 4.841 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.447499e-05 4.839 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.842653e-05 4.735 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.205519e-05 4.656 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.480529e-05 4.605 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.480529e-05 4.605 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.480529e-05 4.605 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.047983e-05 4.516 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 3.279261e-05 4.484 0 0
Gene expression (Transcription) R-HSA-74160 3.355657e-05 4.474 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.421564e-05 4.466 0 0
Death Receptor Signaling R-HSA-73887 3.444900e-05 4.463 0 0
Cell junction organization R-HSA-446728 3.702621e-05 4.431 0 0
Host Interactions of HIV factors R-HSA-162909 3.716071e-05 4.430 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 4.287147e-05 4.368 0 0
Nucleosome assembly R-HSA-774815 4.341933e-05 4.362 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 4.341933e-05 4.362 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.315456e-05 4.365 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 4.324342e-05 4.364 0 0
Autophagy R-HSA-9612973 4.518563e-05 4.345 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.820441e-05 4.317 0 0
L1CAM interactions R-HSA-373760 4.821351e-05 4.317 0 0
DNA Double Strand Break Response R-HSA-5693606 5.284785e-05 4.277 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 5.359379e-05 4.271 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 5.359379e-05 4.271 0 0
Interleukin-12 signaling R-HSA-9020591 5.425818e-05 4.266 0 0
Semaphorin interactions R-HSA-373755 5.719749e-05 4.243 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 5.751707e-05 4.240 0 0
DNA Double-Strand Break Repair R-HSA-5693532 5.939437e-05 4.226 0 0
Signaling by NOTCH R-HSA-157118 6.217713e-05 4.206 0 0
Ub-specific processing proteases R-HSA-5689880 6.420397e-05 4.192 0 0
DNA methylation R-HSA-5334118 6.851925e-05 4.164 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 7.212536e-05 4.142 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 7.292315e-05 4.137 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 7.292315e-05 4.137 0 0
Macroautophagy R-HSA-1632852 7.891553e-05 4.103 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 9.457444e-05 4.024 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 9.805261e-05 4.009 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 9.910854e-05 4.004 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.090701e-04 3.962 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.042899e-04 3.982 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.068992e-04 3.971 0 0
Adherens junctions interactions R-HSA-418990 1.026536e-04 3.989 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.094778e-04 3.961 0 0
Diseases of programmed cell death R-HSA-9645723 1.109355e-04 3.955 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.137971e-04 3.944 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.178918e-04 3.929 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.209908e-04 3.917 0 0
Packaging Of Telomere Ends R-HSA-171306 1.209908e-04 3.917 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.282587e-04 3.892 0 0
Homology Directed Repair R-HSA-5693538 1.362938e-04 3.866 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.314481e-04 3.881 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.381713e-04 3.860 0 0
ESR-mediated signaling R-HSA-8939211 1.386046e-04 3.858 0 0
G2/M Transition R-HSA-69275 1.615470e-04 3.792 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.640874e-04 3.785 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.661690e-04 3.779 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.736295e-04 3.760 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.881075e-04 3.726 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.868867e-04 3.728 0 0
G alpha (12/13) signalling events R-HSA-416482 1.881075e-04 3.726 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.952257e-04 3.709 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.952257e-04 3.709 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.972314e-04 3.705 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.019397e-04 3.695 0 0
Interleukin-12 family signaling R-HSA-447115 2.094938e-04 3.679 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.108091e-04 3.676 0 0
Defective pyroptosis R-HSA-9710421 2.110127e-04 3.676 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 2.206825e-04 3.656 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.163764e-04 3.665 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.291920e-04 3.640 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.291920e-04 3.640 0 0
Signal Transduction R-HSA-162582 2.192192e-04 3.659 1 0
Metabolism of RNA R-HSA-8953854 2.542617e-04 3.595 0 0
G2/M Checkpoints R-HSA-69481 2.726059e-04 3.564 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.806413e-04 3.552 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 2.826314e-04 3.549 0 0
Metalloprotease DUBs R-HSA-5689901 2.930818e-04 3.533 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.117168e-04 3.506 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.178671e-04 3.498 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.222439e-04 3.492 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 3.451319e-04 3.462 0 0
Translation initiation complex formation R-HSA-72649 3.544967e-04 3.450 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 3.793218e-04 3.421 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 3.903675e-04 3.409 0 0
Depurination R-HSA-73927 3.785403e-04 3.422 0 0
snRNP Assembly R-HSA-191859 3.928977e-04 3.406 0 0
Metabolism of non-coding RNA R-HSA-194441 3.928977e-04 3.406 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.960724e-04 3.402 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 4.004396e-04 3.397 0 0
Signaling by Hippo R-HSA-2028269 4.293637e-04 3.367 0 0
Glycolysis R-HSA-70171 4.795995e-04 3.319 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 4.799025e-04 3.319 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 4.825075e-04 3.316 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 5.504767e-04 3.259 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 5.211470e-04 3.283 0 0
COPI-mediated anterograde transport R-HSA-6807878 5.504767e-04 3.259 0 0
Cell-extracellular matrix interactions R-HSA-446353 5.226140e-04 3.282 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 5.455152e-04 3.263 0 0
Cell-cell junction organization R-HSA-421270 5.225275e-04 3.282 0 0
NRAGE signals death through JNK R-HSA-193648 5.300099e-04 3.276 0 0
PKR-mediated signaling R-HSA-9833482 5.937155e-04 3.226 0 0
Meiosis R-HSA-1500620 6.106142e-04 3.214 0 0
Regulation of endogenous retroelements R-HSA-9842860 6.380295e-04 3.195 0 0
HIV Life Cycle R-HSA-162587 6.388746e-04 3.195 0 0
Regulation of CDH1 Function R-HSA-9764561 6.431217e-04 3.192 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 6.456630e-04 3.190 0 0
Josephin domain DUBs R-HSA-5689877 6.880351e-04 3.162 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 6.921846e-04 3.160 0 0
tRNA processing in the nucleus R-HSA-6784531 6.921846e-04 3.160 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 7.017934e-04 3.154 0 0
DNA Replication R-HSA-69306 7.382243e-04 3.132 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 8.221696e-04 3.085 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 8.236822e-04 3.084 0 0
Vesicle-mediated transport R-HSA-5653656 7.716299e-04 3.113 0 0
HCMV Infection R-HSA-9609646 7.803408e-04 3.108 0 0
Cleavage of the damaged purine R-HSA-110331 8.221696e-04 3.085 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 8.714102e-04 3.060 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 8.715220e-04 3.060 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 8.725534e-04 3.059 0 0
DNA Repair R-HSA-73894 8.768947e-04 3.057 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 9.373309e-04 3.028 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 9.540677e-04 3.020 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.071584e-03 2.970 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.071584e-03 2.970 0 0
Kinesins R-HSA-983189 1.116421e-03 2.952 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.180412e-03 2.928 0 0
Depyrimidination R-HSA-73928 1.180412e-03 2.928 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.196053e-03 2.922 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.210564e-03 2.917 0 0
Protein ubiquitination R-HSA-8852135 1.247912e-03 2.904 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.259269e-03 2.900 0 0
TNF signaling R-HSA-75893 1.259269e-03 2.900 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.280345e-03 2.893 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.416303e-03 2.849 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.385222e-03 2.858 0 0
UCH proteinases R-HSA-5689603 1.456988e-03 2.837 0 0
Oncogene Induced Senescence R-HSA-2559585 1.397837e-03 2.855 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.494672e-03 2.825 0 0
Chromosome Maintenance R-HSA-73886 1.496112e-03 2.825 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.621869e-03 2.790 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.688321e-03 2.773 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.842524e-03 2.735 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.861704e-03 2.730 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.861704e-03 2.730 0 0
Apoptosis R-HSA-109581 1.889145e-03 2.724 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.893603e-03 2.723 0 0
HIV Infection R-HSA-162906 1.938196e-03 2.713 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.947212e-03 2.711 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.951777e-03 2.710 0 0
Co-inhibition by PD-1 R-HSA-389948 1.951777e-03 2.710 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.966444e-03 2.706 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.966444e-03 2.706 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.968571e-03 2.706 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.117097e-03 2.674 0 0
Ephrin signaling R-HSA-3928664 2.132670e-03 2.671 0 0
RNA Polymerase II Transcription R-HSA-73857 2.180623e-03 2.661 0 0
EPH-Ephrin signaling R-HSA-2682334 2.230537e-03 2.652 0 0
Striated Muscle Contraction R-HSA-390522 2.370399e-03 2.625 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 2.593544e-03 2.586 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.602559e-03 2.585 0 0
Centrosome maturation R-HSA-380287 2.620347e-03 2.582 0 0
Telomere Maintenance R-HSA-157579 2.495373e-03 2.603 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.383140e-03 2.623 0 0
Signaling by ROBO receptors R-HSA-376176 2.533587e-03 2.596 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.728330e-03 2.564 0 0
Meiotic recombination R-HSA-912446 2.744643e-03 2.562 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.832418e-03 2.548 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.832418e-03 2.548 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.878919e-03 2.541 0 0
Interferon Signaling R-HSA-913531 2.916985e-03 2.535 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 3.019452e-03 2.520 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.022264e-03 2.520 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 3.057065e-03 2.515 0 0
Rab regulation of trafficking R-HSA-9007101 3.167015e-03 2.499 0 0
Regulation of PTEN localization R-HSA-8948747 3.541894e-03 2.451 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 3.673668e-03 2.435 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 3.673668e-03 2.435 0 0
Smooth Muscle Contraction R-HSA-445355 3.853790e-03 2.414 0 0
Chaperonin-mediated protein folding R-HSA-390466 3.875424e-03 2.412 0 0
Post NMDA receptor activation events R-HSA-438064 3.875424e-03 2.412 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.879537e-03 2.411 0 0
Gap junction trafficking R-HSA-190828 4.215040e-03 2.375 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.254425e-03 2.371 0 0
Protein folding R-HSA-391251 4.295640e-03 2.367 0 0
Gap junction trafficking and regulation R-HSA-157858 4.403786e-03 2.356 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 4.533911e-03 2.344 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 4.550260e-03 2.342 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.663936e-03 2.331 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 4.721133e-03 2.326 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 4.721133e-03 2.326 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 4.773627e-03 2.321 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 4.944041e-03 2.306 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 5.627435e-03 2.250 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 5.501070e-03 2.260 0 0
Signaling by NOTCH3 R-HSA-9012852 5.309728e-03 2.275 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 5.463299e-03 2.263 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 4.944041e-03 2.306 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 5.572434e-03 2.254 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 5.386448e-03 2.269 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 5.309728e-03 2.275 0 0
Base Excision Repair R-HSA-73884 5.627435e-03 2.250 0 0
Glucose metabolism R-HSA-70326 5.631616e-03 2.249 0 0
Signaling by RAF1 mutants R-HSA-9656223 5.718659e-03 2.243 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 5.954403e-03 2.225 0 0
Signaling downstream of RAS mutants R-HSA-9649948 5.954403e-03 2.225 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 5.954403e-03 2.225 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 5.954403e-03 2.225 0 0
Signaling by RAS mutants R-HSA-6802949 5.954403e-03 2.225 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 6.038093e-03 2.219 0 0
Generic Transcription Pathway R-HSA-212436 6.063592e-03 2.217 0 0
ER to Golgi Anterograde Transport R-HSA-199977 6.200494e-03 2.208 0 0
Viral Messenger RNA Synthesis R-HSA-168325 6.216093e-03 2.206 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 6.379869e-03 2.195 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.422891e-03 2.192 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 6.530477e-03 2.185 0 0
NF-kB is activated and signals survival R-HSA-209560 6.536725e-03 2.185 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 6.536725e-03 2.185 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 6.751761e-03 2.171 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 6.846786e-03 2.165 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 6.846786e-03 2.165 0 0
mRNA 3'-end processing R-HSA-72187 7.140729e-03 2.146 0 0
Regulation of TP53 Activity R-HSA-5633007 7.248353e-03 2.140 0 0
RNA Polymerase I Transcription R-HSA-73864 7.795471e-03 2.108 0 0
SARS-CoV-2-host interactions R-HSA-9705683 7.862017e-03 2.104 0 0
TBC/RABGAPs R-HSA-8854214 8.060020e-03 2.094 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.263115e-03 2.083 0 0
Signaling by NOTCH4 R-HSA-9013694 9.060037e-03 2.043 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 9.237685e-03 2.034 0 0
RMTs methylate histone arginines R-HSA-3214858 9.487313e-03 2.023 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 9.487313e-03 2.023 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 9.948979e-03 2.002 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 1.079520e-02 1.967 0 0
S Phase R-HSA-69242 1.103123e-02 1.957 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.194883e-02 1.923 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.194883e-02 1.923 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 1.198870e-02 1.921 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.198870e-02 1.921 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.207945e-02 1.918 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.256399e-02 1.901 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.406362e-02 1.852 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.406362e-02 1.852 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.406362e-02 1.852 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.485001e-02 1.828 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.347834e-02 1.870 0 0
Signaling by WNT R-HSA-195721 1.530039e-02 1.815 0 0
Influenza Infection R-HSA-168255 1.423697e-02 1.847 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.542672e-02 1.812 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.547031e-02 1.811 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.568795e-02 1.804 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.634031e-02 1.787 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.652922e-02 1.782 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.662870e-02 1.779 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.684945e-02 1.773 0 0
Mitophagy R-HSA-5205647 1.711158e-02 1.767 0 0
Gap junction assembly R-HSA-190861 1.711158e-02 1.767 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.742802e-02 1.759 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.746776e-02 1.758 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.747162e-02 1.758 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.747162e-02 1.758 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.750174e-02 1.757 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.782431e-02 1.749 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.794881e-02 1.746 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.905678e-02 1.720 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.905678e-02 1.720 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.905678e-02 1.720 0 0
EGFR downregulation R-HSA-182971 1.972448e-02 1.705 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.984964e-02 1.702 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.014720e-02 1.696 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 2.045243e-02 1.689 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 2.045243e-02 1.689 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 2.045243e-02 1.689 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 2.045243e-02 1.689 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 2.045243e-02 1.689 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 2.045243e-02 1.689 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 2.045243e-02 1.689 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 2.045243e-02 1.689 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 2.045243e-02 1.689 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 2.045243e-02 1.689 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 2.045243e-02 1.689 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 2.045243e-02 1.689 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 2.222581e-02 1.653 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 2.222581e-02 1.653 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.117444e-02 1.674 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.117444e-02 1.674 0 0
Regulation of signaling by CBL R-HSA-912631 2.417825e-02 1.617 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 2.417825e-02 1.617 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 2.269249e-02 1.644 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 2.500040e-02 1.602 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.611875e-02 1.583 0 0
Nucleotide Excision Repair R-HSA-5696398 2.107496e-02 1.676 0 0
Signaling by ERBB2 R-HSA-1227986 2.138886e-02 1.670 0 0
Signaling by EGFR R-HSA-177929 2.500040e-02 1.602 0 0
Eukaryotic Translation Elongation R-HSA-156842 2.484185e-02 1.605 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.581326e-02 1.588 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 2.337343e-02 1.631 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 2.144489e-02 1.669 0 0
p75NTR signals via NF-kB R-HSA-193639 2.117444e-02 1.674 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.222581e-02 1.653 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.411484e-02 1.618 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.440304e-02 1.613 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 2.223943e-02 1.653 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.269249e-02 1.644 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 2.222581e-02 1.653 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.500040e-02 1.602 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.630863e-02 1.580 0 0
Programmed Cell Death R-HSA-5357801 2.663508e-02 1.575 0 0
Negative regulation of FLT3 R-HSA-9706369 2.692089e-02 1.570 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 2.704044e-02 1.568 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.742232e-02 1.562 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.742232e-02 1.562 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.763267e-02 1.559 0 0
Muscle contraction R-HSA-397014 2.830932e-02 1.548 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 2.912835e-02 1.536 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 2.912835e-02 1.536 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.912835e-02 1.536 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.912835e-02 1.536 0 0
Maturation of protein E R-HSA-9683683 2.912835e-02 1.536 0 0
Maturation of protein E R-HSA-9694493 2.912835e-02 1.536 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 2.925862e-02 1.534 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.933042e-02 1.533 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.933042e-02 1.533 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.933042e-02 1.533 0 0
IRAK1 recruits IKK complex R-HSA-937039 2.933042e-02 1.533 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 2.933042e-02 1.533 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.933042e-02 1.533 0 0
Negative regulation of MET activity R-HSA-6807004 2.971115e-02 1.527 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.005859e-02 1.522 0 0
Cilium Assembly R-HSA-5617833 3.010165e-02 1.521 0 0
PTEN Regulation R-HSA-6807070 3.064340e-02 1.514 0 0
Unfolded Protein Response (UPR) R-HSA-381119 3.064340e-02 1.514 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.064925e-02 1.514 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 3.064925e-02 1.514 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 3.064925e-02 1.514 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.064925e-02 1.514 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.126417e-02 1.505 0 0
Neurodegenerative Diseases R-HSA-8863678 3.126417e-02 1.505 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.126417e-02 1.505 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 3.174881e-02 1.498 0 0
Activation of HOX genes during differentiation R-HSA-5619507 3.174881e-02 1.498 0 0
Late endosomal microautophagy R-HSA-9615710 3.195209e-02 1.496 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.195209e-02 1.496 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.203521e-02 1.494 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 3.302662e-02 1.481 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 3.302662e-02 1.481 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.390067e-02 1.470 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 3.390067e-02 1.470 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.390067e-02 1.470 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.390067e-02 1.470 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.390067e-02 1.470 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 3.390067e-02 1.470 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.390067e-02 1.470 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 3.601631e-02 1.444 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 4.183190e-02 1.378 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 4.183190e-02 1.378 0 0
Folding of actin by CCT/TriC R-HSA-390450 4.083939e-02 1.389 0 0
Disorders of Developmental Biology R-HSA-9675151 3.364493e-02 1.473 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.364493e-02 1.473 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.364493e-02 1.473 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 4.325840e-02 1.364 0 0
Signaling by EGFR in Cancer R-HSA-1643713 4.383990e-02 1.358 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 4.383990e-02 1.358 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 4.358838e-02 1.361 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 3.714118e-02 1.430 0 0
Degradation of CDH1 R-HSA-9766229 3.873393e-02 1.412 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.160206e-02 1.381 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 3.395608e-02 1.469 0 0
DNA Damage Bypass R-HSA-73893 3.873393e-02 1.412 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 3.745870e-02 1.426 0 0
Signaling by NOTCH2 R-HSA-1980145 3.714118e-02 1.430 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 3.364493e-02 1.473 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 3.963251e-02 1.402 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 3.963251e-02 1.402 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 3.963251e-02 1.402 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 3.963251e-02 1.402 0 0
Signaling by NOTCH1 R-HSA-1980143 3.749221e-02 1.426 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 4.279045e-02 1.369 0 0
MAP kinase activation R-HSA-450294 4.409431e-02 1.356 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 3.605734e-02 1.443 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.963251e-02 1.402 0 0
Signaling by PDGFR in disease R-HSA-9671555 4.325840e-02 1.364 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 4.140133e-02 1.383 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 3.963251e-02 1.402 0 0
Pexophagy R-HSA-9664873 4.083939e-02 1.389 0 0
Amyloid fiber formation R-HSA-977225 3.546382e-02 1.450 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.679518e-02 1.434 0 0
IRE1alpha activates chaperones R-HSA-381070 3.796608e-02 1.421 0 0
SARS-CoV-1 Infection R-HSA-9678108 3.626801e-02 1.440 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 4.643736e-02 1.333 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 4.643736e-02 1.333 0 0
MITF-M-dependent gene expression R-HSA-9856651 4.660395e-02 1.332 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 4.715265e-02 1.326 0 0
NRIF signals cell death from the nucleus R-HSA-205043 4.715265e-02 1.326 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 4.900461e-02 1.310 0 0
RET signaling R-HSA-8853659 4.900461e-02 1.310 0 0
FLT3 signaling in disease R-HSA-9682385 4.900461e-02 1.310 0 0
HCMV Late Events R-HSA-9610379 4.967578e-02 1.304 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 5.023319e-02 1.299 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 5.023319e-02 1.299 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 5.036565e-02 1.298 0 0
Diseases of mitotic cell cycle R-HSA-9675126 5.036565e-02 1.298 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 5.101509e-02 1.292 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 5.121428e-02 1.291 0 0
mTORC1-mediated signalling R-HSA-166208 5.134843e-02 1.289 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 5.134843e-02 1.289 0 0
Reproduction R-HSA-1474165 5.271743e-02 1.278 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 5.285500e-02 1.277 0 0
MAP2K and MAPK activation R-HSA-5674135 5.356594e-02 1.271 0 0
Hedgehog 'off' state R-HSA-5610787 5.403230e-02 1.267 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.406656e-02 1.267 0 0
Signaling by PTK6 R-HSA-8848021 5.406656e-02 1.267 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.406656e-02 1.267 0 0
mRNA Splicing - Major Pathway R-HSA-72163 5.453928e-02 1.263 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 5.470336e-02 1.262 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 5.567367e-02 1.254 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 5.599907e-02 1.252 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 5.616135e-02 1.251 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 5.616135e-02 1.251 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 5.616135e-02 1.251 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 5.720164e-02 1.243 0 0
MECP2 regulates transcription factors R-HSA-9022707 5.720164e-02 1.243 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 5.720164e-02 1.243 0 0
Recycling of eIF2:GDP R-HSA-72731 5.720164e-02 1.243 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 5.720164e-02 1.243 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 5.739537e-02 1.241 0 0
Formation of a pool of free 40S subunits R-HSA-72689 5.762854e-02 1.239 0 0
Developmental Biology R-HSA-1266738 5.778884e-02 1.238 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.812009e-02 1.236 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 5.812009e-02 1.236 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 5.812009e-02 1.236 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 5.812009e-02 1.236 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.812009e-02 1.236 0 0
Spry regulation of FGF signaling R-HSA-1295596 5.812009e-02 1.236 0 0
Signaling by Nuclear Receptors R-HSA-9006931 5.824682e-02 1.235 0 0
Translesion Synthesis by POLH R-HSA-110320 6.017111e-02 1.221 0 0
STING mediated induction of host immune responses R-HSA-1834941 6.017111e-02 1.221 0 0
Circadian clock R-HSA-9909396 6.023198e-02 1.220 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 6.031803e-02 1.220 0 0
Organelle biogenesis and maintenance R-HSA-1852241 6.145614e-02 1.211 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 6.148587e-02 1.211 0 0
Interleukin-17 signaling R-HSA-448424 6.155212e-02 1.211 0 0
Synthesis of DNA R-HSA-69239 6.342997e-02 1.198 0 0
MHC class II antigen presentation R-HSA-2132295 6.420941e-02 1.192 0 0
Defective Base Excision Repair Associated with OGG1 R-HSA-9656249 6.954376e-02 1.158 0 0
Manipulation of host energy metabolism R-HSA-9636667 6.954376e-02 1.158 0 0
IKBKB deficiency causes SCID R-HSA-5602636 6.954376e-02 1.158 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 6.954376e-02 1.158 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 6.954376e-02 1.158 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 6.954376e-02 1.158 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 6.954376e-02 1.158 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 8.054719e-02 1.094 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 8.054719e-02 1.094 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 7.518751e-02 1.124 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 7.518751e-02 1.124 0 0
Formation of annular gap junctions R-HSA-196025 7.518751e-02 1.124 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 7.518751e-02 1.124 0 0
Gap junction degradation R-HSA-190873 9.566841e-02 1.019 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 8.240188e-02 1.084 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 8.240188e-02 1.084 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 8.240188e-02 1.084 0 0
Pervasive developmental disorders R-HSA-9005895 8.240188e-02 1.084 0 0
Disorders of Nervous System Development R-HSA-9697154 8.240188e-02 1.084 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.240188e-02 1.084 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 8.240188e-02 1.084 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 8.342252e-02 1.079 0 0
Termination of translesion DNA synthesis R-HSA-5656169 6.838807e-02 1.165 0 0
RAF activation R-HSA-5673000 7.476711e-02 1.126 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.908930e-02 1.050 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.282726e-02 1.032 0 0
Orc1 removal from chromatin R-HSA-68949 9.572760e-02 1.019 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.561436e-02 1.019 0 0
mRNA Splicing R-HSA-72172 7.050542e-02 1.152 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 8.911682e-02 1.050 0 0
Early Phase of HIV Life Cycle R-HSA-162594 8.342252e-02 1.079 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 8.342252e-02 1.079 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 8.116893e-02 1.091 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 8.116893e-02 1.091 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 7.348931e-02 1.134 0 0
TGFBR3 expression R-HSA-9839394 8.116893e-02 1.091 0 0
HSF1-dependent transactivation R-HSA-3371571 8.704918e-02 1.060 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.326286e-02 1.080 0 0
Integration of provirus R-HSA-162592 6.671529e-02 1.176 0 0
Myogenesis R-HSA-525793 9.298786e-02 1.032 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 8.908930e-02 1.050 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.381480e-02 1.077 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.827290e-02 1.106 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.827290e-02 1.106 0 0
Adrenoceptors R-HSA-390696 7.518751e-02 1.124 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.673212e-02 1.014 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 8.704918e-02 1.060 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 7.476711e-02 1.126 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.240188e-02 1.084 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 8.425655e-02 1.074 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 6.715468e-02 1.173 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 7.048913e-02 1.152 0 0
Signaling by VEGF R-HSA-194138 7.805560e-02 1.108 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 7.120755e-02 1.147 0 0
Signaling by TGFB family members R-HSA-9006936 8.456157e-02 1.073 0 0
Breakdown of the nuclear lamina R-HSA-352238 6.954376e-02 1.158 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.939908e-02 1.003 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 9.939908e-02 1.003 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.298786e-02 1.032 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.873912e-02 1.052 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 7.846838e-02 1.105 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.316807e-02 1.031 0 0
Signal transduction by L1 R-HSA-445144 7.123271e-02 1.147 0 0
Nephrin family interactions R-HSA-373753 7.123271e-02 1.147 0 0
Cellular response to chemical stress R-HSA-9711123 7.551807e-02 1.122 0 0
HDMs demethylate histones R-HSA-3214842 8.116893e-02 1.091 0 0
Negative regulation of MAPK pathway R-HSA-5675221 9.896914e-02 1.005 0 0
NOD1/2 Signaling Pathway R-HSA-168638 7.476711e-02 1.126 0 0
Platelet degranulation R-HSA-114608 8.834274e-02 1.054 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 6.671529e-02 1.176 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 7.029069e-02 1.153 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 7.983588e-02 1.098 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 7.048913e-02 1.152 0 0
Regulation of TP53 Degradation R-HSA-6804757 9.453195e-02 1.024 0 0
Interleukin-37 signaling R-HSA-9008059 7.815999e-02 1.107 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 7.121990e-02 1.147 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 7.121990e-02 1.147 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 7.518751e-02 1.124 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 8.425655e-02 1.074 0 0
Viral Infection Pathways R-HSA-9824446 7.153319e-02 1.145 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.240188e-02 1.084 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.240188e-02 1.084 0 0
Sensory processing of sound R-HSA-9659379 8.119768e-02 1.090 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 9.673212e-02 1.014 0 0
FLT3 Signaling R-HSA-9607240 8.908930e-02 1.050 0 0
Modulation by Mtb of host immune system R-HSA-9637628 7.518751e-02 1.124 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.963669e-02 1.002 0 0
Formation of axial mesoderm R-HSA-9796292 9.986199e-02 1.001 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 9.986199e-02 1.001 0 0
G0 and Early G1 R-HSA-1538133 1.001235e-01 0.999 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.008712e-01 0.996 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 1.023559e-01 0.990 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 1.023559e-01 0.990 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.049168e-01 0.979 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.068753e-01 0.971 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.086887e-01 0.964 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.086887e-01 0.964 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 1.086887e-01 0.964 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 1.086887e-01 0.964 0 0
MTOR signalling R-HSA-165159 1.094730e-01 0.961 0 0
Peptide chain elongation R-HSA-156902 1.100799e-01 0.958 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.123887e-01 0.949 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.128550e-01 0.947 0 0
Diseases of cellular response to stress R-HSA-9675132 1.128550e-01 0.947 0 0
Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) R-HSA-1299308 1.128550e-01 0.947 0 0
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization R-HSA-180897 1.128550e-01 0.947 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.158747e-01 0.936 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.158747e-01 0.936 0 0
2-LTR circle formation R-HSA-164843 1.184661e-01 0.926 0 0
Signaling by Leptin R-HSA-2586552 1.184661e-01 0.926 0 0
Regulation of CDH11 function R-HSA-9762292 1.184661e-01 0.926 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.184661e-01 0.926 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.190124e-01 0.924 0 0
CRMPs in Sema3A signaling R-HSA-399956 1.190124e-01 0.924 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 1.190124e-01 0.924 0 0
Response of Mtb to phagocytosis R-HSA-9637690 1.205946e-01 0.919 0 0
Signaling by Interleukins R-HSA-449147 1.210195e-01 0.917 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.253535e-01 0.902 0 0
Stabilization of p53 R-HSA-69541 1.294240e-01 0.888 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.294240e-01 0.888 0 0
Ribosome-associated quality control R-HSA-9948299 1.295587e-01 0.888 0 0
Signaling by Hedgehog R-HSA-5358351 1.295587e-01 0.888 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.300078e-01 0.886 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.300078e-01 0.886 0 0
Inositol phosphate metabolism R-HSA-1483249 1.300078e-01 0.886 0 0
Cyclin D associated events in G1 R-HSA-69231 1.323243e-01 0.878 0 0
G1 Phase R-HSA-69236 1.323243e-01 0.878 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 1.323243e-01 0.878 0 0
Defective OGG1 Localization R-HSA-9657050 1.333182e-01 0.875 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.333182e-01 0.875 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.333182e-01 0.875 0 0
Deletions in the AXIN1 gene destabilize the destruction complex R-HSA-5467345 1.333182e-01 0.875 0 0
Defective OGG1 Substrate Binding R-HSA-9656255 1.333182e-01 0.875 0 0
Eukaryotic Translation Termination R-HSA-72764 1.335235e-01 0.874 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 1.339565e-01 0.873 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.344810e-01 0.871 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 1.389945e-01 0.857 0 0
Dual Incision in GG-NER R-HSA-5696400 1.389945e-01 0.857 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.392573e-01 0.856 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 1.397438e-01 0.855 0 0
DCC mediated attractive signaling R-HSA-418885 1.397438e-01 0.855 0 0
Translesion synthesis by REV1 R-HSA-110312 1.397438e-01 0.855 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 1.400212e-01 0.854 0 0
Autointegration results in viral DNA circles R-HSA-177539 1.400212e-01 0.854 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 1.400212e-01 0.854 0 0
Nef and signal transduction R-HSA-164944 1.400212e-01 0.854 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 1.400212e-01 0.854 0 0
Glycogen metabolism R-HSA-8982491 1.424105e-01 0.846 0 0
PECAM1 interactions R-HSA-210990 1.433589e-01 0.844 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 1.433589e-01 0.844 0 0
Cellular response to starvation R-HSA-9711097 1.438543e-01 0.842 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.446486e-01 0.840 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.446486e-01 0.840 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.466784e-01 0.834 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.468926e-01 0.833 0 0
Activation of the pre-replicative complex R-HSA-68962 1.493651e-01 0.826 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.493651e-01 0.826 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.525745e-01 0.817 0 0
Glycogen synthesis R-HSA-3322077 1.525745e-01 0.817 0 0
Regulation of Apoptosis R-HSA-169911 1.534564e-01 0.814 0 0
SARS-CoV Infections R-HSA-9679506 1.540727e-01 0.812 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.560438e-01 0.807 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.575358e-01 0.803 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.575358e-01 0.803 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.575358e-01 0.803 0 0
G1/S Transition R-HSA-69206 1.575358e-01 0.803 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 1.582611e-01 0.801 0 0
Dual incision in TC-NER R-HSA-6782135 1.583739e-01 0.800 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.598389e-01 0.796 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.598389e-01 0.796 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.598389e-01 0.796 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 1.611581e-01 0.793 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 1.611581e-01 0.793 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.619256e-01 0.791 0 0
Translesion synthesis by POLI R-HSA-5656121 1.619256e-01 0.791 0 0
Phosphorylation of the APC/C R-HSA-176412 1.619256e-01 0.791 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.619256e-01 0.791 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.619256e-01 0.791 0 0
Prolonged ERK activation events R-HSA-169893 1.619256e-01 0.791 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 1.619256e-01 0.791 0 0
Regulation of BACH1 activity R-HSA-9708530 1.619256e-01 0.791 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 1.622160e-01 0.790 0 0
MAPK family signaling cascades R-HSA-5683057 1.641550e-01 0.785 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.655887e-01 0.781 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.683924e-01 0.774 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.683924e-01 0.774 0 0
HSF1 activation R-HSA-3371511 1.686232e-01 0.773 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 1.686232e-01 0.773 0 0
G1/S-Specific Transcription R-HSA-69205 1.686232e-01 0.773 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 1.700946e-01 0.769 0 0
Activation of RAC1 R-HSA-428540 1.700946e-01 0.769 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 1.700946e-01 0.769 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.702993e-01 0.769 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 1.702993e-01 0.769 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 1.702993e-01 0.769 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.702993e-01 0.769 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 1.726377e-01 0.763 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 1.726377e-01 0.763 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 1.739478e-01 0.760 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.739478e-01 0.760 0 0
IFNG signaling activates MAPKs R-HSA-9732724 1.739478e-01 0.760 0 0
SOS-mediated signalling R-HSA-112412 1.739478e-01 0.760 0 0
CHL1 interactions R-HSA-447041 1.739478e-01 0.760 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.739478e-01 0.760 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.744387e-01 0.758 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 1.789540e-01 0.747 0 0
rRNA processing R-HSA-72312 1.790401e-01 0.747 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.798348e-01 0.745 0 0
Defective OGG1 Substrate Processing R-HSA-9656256 2.488693e-01 0.604 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 2.488693e-01 0.604 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.488693e-01 0.604 0 0
Hereditary fructose intolerance R-HSA-5657560 2.488693e-01 0.604 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 2.488693e-01 0.604 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.488693e-01 0.604 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 2.488693e-01 0.604 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.488693e-01 0.604 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.488693e-01 0.604 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.488693e-01 0.604 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.488693e-01 0.604 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 2.123535e-01 0.673 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 2.123535e-01 0.673 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.123535e-01 0.673 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.123535e-01 0.673 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.490203e-01 0.457 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.490203e-01 0.457 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.490203e-01 0.457 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 3.490203e-01 0.457 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 3.490203e-01 0.457 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 3.490203e-01 0.457 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 3.490203e-01 0.457 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.490203e-01 0.457 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.490203e-01 0.457 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.490203e-01 0.457 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.490203e-01 0.457 0 0
Defective VWF binding to collagen type I R-HSA-9845622 3.490203e-01 0.457 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 3.490203e-01 0.457 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 2.648124e-01 0.577 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.648124e-01 0.577 0 0
IRS activation R-HSA-74713 2.648124e-01 0.577 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.648124e-01 0.577 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 2.648124e-01 0.577 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 2.648124e-01 0.577 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 2.648124e-01 0.577 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.648124e-01 0.577 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.472291e-01 0.607 0 0
Lipophagy R-HSA-9613354 2.472291e-01 0.607 0 0
WNT mediated activation of DVL R-HSA-201688 2.472291e-01 0.607 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 2.472291e-01 0.607 0 0
Calcineurin activates NFAT R-HSA-2025928 2.472291e-01 0.607 0 0
ALK mutants bind TKIs R-HSA-9700645 2.472291e-01 0.607 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.172885e-01 0.499 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 3.172885e-01 0.499 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 3.172885e-01 0.499 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 3.172885e-01 0.499 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 3.172885e-01 0.499 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 3.172885e-01 0.499 0 0
Translesion synthesis by POLK R-HSA-5655862 1.854106e-01 0.732 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.280006e-01 0.642 0 0
CD28 dependent Vav1 pathway R-HSA-389359 2.280006e-01 0.642 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 2.854855e-01 0.544 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 2.854855e-01 0.544 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.100395e-01 0.678 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.100395e-01 0.678 0 0
Notch-HLH transcription pathway R-HSA-350054 2.157055e-01 0.666 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.981658e-01 0.703 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.981658e-01 0.703 0 0
Erythropoietin activates RAS R-HSA-9027284 2.899538e-01 0.538 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 2.620562e-01 0.582 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.002894e-01 0.698 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 1.844586e-01 0.734 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.387942e-01 0.622 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.619600e-01 0.582 0 0
Deadenylation of mRNA R-HSA-429947 2.619600e-01 0.582 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.619600e-01 0.582 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 2.891013e-01 0.539 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 3.628417e-01 0.440 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 3.628417e-01 0.440 0 0
Signaling by AXIN mutants R-HSA-4839735 3.628417e-01 0.440 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 3.628417e-01 0.440 0 0
Signaling by GSK3beta mutants R-HSA-5339716 3.628417e-01 0.440 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.600459e-01 0.585 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.355545e-01 0.628 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 2.571251e-01 0.590 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 2.571251e-01 0.590 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 3.538122e-01 0.451 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.144879e-01 0.669 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.444222e-01 0.463 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.444222e-01 0.463 0 0
Degradation of CRY and PER proteins R-HSA-9932298 2.721296e-01 0.565 0 0
Degradation of AXIN R-HSA-4641257 2.974636e-01 0.527 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.917859e-01 0.717 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 3.493911e-01 0.457 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 3.579553e-01 0.446 0 0
Formation of definitive endoderm R-HSA-9823730 2.891013e-01 0.539 0 0
Interleukin-23 signaling R-HSA-9020933 2.098736e-01 0.678 0 0
PCP/CE pathway R-HSA-4086400 2.557944e-01 0.592 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.333237e-01 0.632 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 3.602828e-01 0.443 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 3.181641e-01 0.497 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.608298e-01 0.443 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.902305e-01 0.537 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 3.217704e-01 0.492 0 0
Regulation of necroptotic cell death R-HSA-5675482 2.002894e-01 0.698 0 0
Degradation of DVL R-HSA-4641258 1.844586e-01 0.734 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 2.329179e-01 0.633 0 0
Frs2-mediated activation R-HSA-170968 2.280006e-01 0.642 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 2.854855e-01 0.544 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.002894e-01 0.698 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.770320e-01 0.557 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 2.670660e-01 0.573 0 0
PI3K/AKT activation R-HSA-198203 2.854855e-01 0.544 0 0
Attenuation phase R-HSA-3371568 2.355545e-01 0.628 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.155568e-01 0.666 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 2.761735e-01 0.559 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 2.761735e-01 0.559 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 3.107034e-01 0.508 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.123535e-01 0.673 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 2.280006e-01 0.642 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.937167e-01 0.713 0 0
Trafficking of AMPA receptors R-HSA-399719 2.818076e-01 0.550 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 2.299184e-01 0.638 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 3.107034e-01 0.508 0 0
Nuclear RNA decay R-HSA-9930044 3.265083e-01 0.486 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.056582e-01 0.687 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 3.533417e-01 0.452 0 0
Signal attenuation R-HSA-74749 2.854855e-01 0.544 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 2.586094e-01 0.587 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 2.179701e-01 0.662 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 3.492715e-01 0.457 0 0
NADE modulates death signalling R-HSA-205025 2.123535e-01 0.673 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 2.648124e-01 0.577 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 2.472291e-01 0.607 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 2.472291e-01 0.607 0 0
Intraflagellar transport R-HSA-5620924 1.850039e-01 0.733 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 3.047463e-01 0.516 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 3.493911e-01 0.457 0 0
Platelet activation, signaling and aggregation R-HSA-76002 2.409305e-01 0.618 0 0
Cellular response to hypoxia R-HSA-1234174 3.546175e-01 0.450 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.002894e-01 0.698 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.163462e-01 0.665 0 0
Signaling by FGFR4 R-HSA-5654743 3.102229e-01 0.508 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 3.104669e-01 0.508 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.201062e-01 0.657 0 0
Signaling by FGFR3 R-HSA-5654741 3.493911e-01 0.457 0 0
Signaling by LTK R-HSA-9842663 1.984020e-01 0.702 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 3.172885e-01 0.499 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 2.586094e-01 0.587 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 2.159777e-01 0.666 0 0
Generation of second messenger molecules R-HSA-202433 3.602828e-01 0.443 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.046202e-01 0.689 0 0
Neurexins and neuroligins R-HSA-6794361 3.579553e-01 0.446 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.181394e-01 0.661 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.387942e-01 0.622 0 0
Calmodulin induced events R-HSA-111933 2.770943e-01 0.557 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.826268e-01 0.738 0 0
Protein methylation R-HSA-8876725 2.899538e-01 0.538 0 0
Signaling by MET R-HSA-6806834 2.008588e-01 0.697 0 0
CaM pathway R-HSA-111997 2.770943e-01 0.557 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 2.595010e-01 0.586 0 0
DAG and IP3 signaling R-HSA-1489509 2.329179e-01 0.633 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 3.265083e-01 0.486 0 0
Netrin-1 signaling R-HSA-373752 2.164940e-01 0.665 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.602828e-01 0.443 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.708919e-01 0.567 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.636532e-01 0.579 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 2.471209e-01 0.607 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 2.536251e-01 0.596 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.488693e-01 0.604 0 0
MTF1 activates gene expression R-HSA-5660489 2.123535e-01 0.673 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 3.490203e-01 0.457 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 3.490203e-01 0.457 0 0
Sodium/Proton exchangers R-HSA-425986 2.098736e-01 0.678 0 0
Regulation of KIT signaling R-HSA-1433559 2.586094e-01 0.587 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.384920e-01 0.623 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 2.181394e-01 0.661 0 0
Signaling by NTRKs R-HSA-166520 3.483115e-01 0.458 0 0
TCR signaling R-HSA-202403 2.265314e-01 0.645 0 0
Heme signaling R-HSA-9707616 3.047463e-01 0.516 0 0
Signaling by TGFBR3 R-HSA-9839373 2.497893e-01 0.602 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 2.942075e-01 0.531 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 1.890712e-01 0.723 0 0
PERK regulates gene expression R-HSA-381042 2.571251e-01 0.590 0 0
The NLRP3 inflammasome R-HSA-844456 2.620562e-01 0.582 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.265083e-01 0.486 0 0
Signaling by ERBB4 R-HSA-1236394 2.902305e-01 0.537 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 2.472291e-01 0.607 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 2.472291e-01 0.607 0 0
Suppression of apoptosis R-HSA-9635465 3.241644e-01 0.489 0 0
Selenocysteine synthesis R-HSA-2408557 2.591408e-01 0.586 0 0
Diseases of DNA repair R-HSA-9675135 2.497893e-01 0.602 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.937167e-01 0.713 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.280006e-01 0.642 0 0
Glycogen storage diseases R-HSA-3229121 2.100395e-01 0.678 0 0
Signal regulatory protein family interactions R-HSA-391160 2.586094e-01 0.587 0 0
Basigin interactions R-HSA-210991 3.166113e-01 0.499 0 0
Vpu mediated degradation of CD4 R-HSA-180534 3.492715e-01 0.457 0 0
FOXO-mediated transcription R-HSA-9614085 2.357053e-01 0.628 0 0
Hedgehog 'on' state R-HSA-5632684 3.447049e-01 0.463 0 0
Stimuli-sensing channels R-HSA-2672351 3.602390e-01 0.443 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 2.648124e-01 0.577 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.984020e-01 0.702 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 3.241644e-01 0.489 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 3.628417e-01 0.440 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.265083e-01 0.486 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.785621e-01 0.555 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 2.721296e-01 0.565 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.265083e-01 0.486 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 2.157055e-01 0.666 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.854855e-01 0.544 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 2.280006e-01 0.642 0 0
Diseases of Base Excision Repair R-HSA-9605308 3.172885e-01 0.499 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 3.172885e-01 0.499 0 0
Assembly Of The HIV Virion R-HSA-175474 3.444222e-01 0.463 0 0
Suppression of phagosomal maturation R-HSA-9637687 3.104669e-01 0.508 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.241644e-01 0.489 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 2.242011e-01 0.649 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 3.538122e-01 0.451 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 3.172885e-01 0.499 0 0
Extension of Telomeres R-HSA-180786 3.652439e-01 0.437 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.688452e-01 0.433 0 0
Signaling by LTK in cancer R-HSA-9842640 3.688452e-01 0.433 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.688452e-01 0.433 0 0
Erythropoietin activates STAT5 R-HSA-9027283 3.688452e-01 0.433 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.688452e-01 0.433 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 3.688452e-01 0.433 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 3.688452e-01 0.433 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.688452e-01 0.433 0 0
Regulation of pyruvate metabolism R-HSA-9861718 3.692391e-01 0.433 0 0
Viral mRNA Translation R-HSA-192823 3.697175e-01 0.432 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 3.712523e-01 0.430 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 3.721950e-01 0.429 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 3.721950e-01 0.429 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 3.721950e-01 0.429 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 3.721950e-01 0.429 0 0
Regulation of PTEN stability and activity R-HSA-8948751 3.767117e-01 0.424 0 0
tRNA processing R-HSA-72306 3.779268e-01 0.423 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 3.815651e-01 0.418 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 3.815651e-01 0.418 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 3.815651e-01 0.418 0 0
Signaling by Erythropoietin R-HSA-9006335 3.854028e-01 0.414 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.854028e-01 0.414 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.854028e-01 0.414 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.858506e-01 0.414 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 3.858506e-01 0.414 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 3.891896e-01 0.410 0 0
Signalling to ERKs R-HSA-187687 3.951953e-01 0.403 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.951953e-01 0.403 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 4.003288e-01 0.398 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 4.003288e-01 0.398 0 0
Syndecan interactions R-HSA-3000170 4.003288e-01 0.398 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 4.009719e-01 0.397 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.011500e-01 0.397 0 0
Polymerase switching R-HSA-69091 4.011500e-01 0.397 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 4.011500e-01 0.397 0 0
Leading Strand Synthesis R-HSA-69109 4.011500e-01 0.397 0 0
Scavenging by Class F Receptors R-HSA-3000484 4.011500e-01 0.397 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 4.011500e-01 0.397 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 4.011500e-01 0.397 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 4.011500e-01 0.397 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 4.011500e-01 0.397 0 0
Regulation of IFNG signaling R-HSA-877312 4.011500e-01 0.397 0 0
Translation of Structural Proteins R-HSA-9683701 4.029078e-01 0.395 0 0
Transcription of the HIV genome R-HSA-167172 4.056593e-01 0.392 0 0
Gluconeogenesis R-HSA-70263 4.091892e-01 0.388 0 0
DAP12 signaling R-HSA-2424491 4.105168e-01 0.387 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.105168e-01 0.387 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.105168e-01 0.387 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.105168e-01 0.387 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.176779e-01 0.379 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 4.176779e-01 0.379 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.176779e-01 0.379 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 4.178691e-01 0.379 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 4.181922e-01 0.379 0 0
RNA Polymerase III Transcription R-HSA-74158 4.181922e-01 0.379 0 0
RUNX2 regulates bone development R-HSA-8941326 4.181922e-01 0.379 0 0
TRIF-mediated programmed cell death R-HSA-2562578 4.187952e-01 0.378 0 0
PTK6 Expression R-HSA-8849473 4.187952e-01 0.378 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 4.187952e-01 0.378 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 4.187952e-01 0.378 0 0
ABC-family proteins mediated transport R-HSA-382556 4.222669e-01 0.374 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.242473e-01 0.372 0 0
Ca-dependent events R-HSA-111996 4.242473e-01 0.372 0 0
Cytoprotection by HMOX1 R-HSA-9707564 4.291803e-01 0.367 0 0
ER-Phagosome pathway R-HSA-1236974 4.318737e-01 0.365 0 0
Signaling by FGFR1 R-HSA-5654736 4.333158e-01 0.363 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 4.333158e-01 0.363 0 0
Ion homeostasis R-HSA-5578775 4.333158e-01 0.363 0 0
Budding and maturation of HIV virion R-HSA-162588 4.355276e-01 0.361 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.358228e-01 0.361 0 0
Signalling to ERK5 R-HSA-198765 4.358228e-01 0.361 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 4.358228e-01 0.361 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 4.358228e-01 0.361 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 4.358228e-01 0.361 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 4.358228e-01 0.361 0 0
Defective visual phototransduction due to ABCA4 loss of function R-HSA-9918454 4.358228e-01 0.361 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.358228e-01 0.361 0 0
Defective ABCD1 causes ALD R-HSA-5684045 4.358228e-01 0.361 0 0
Potassium transport channels R-HSA-1296067 4.358228e-01 0.361 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.358228e-01 0.361 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 4.358228e-01 0.361 0 0
mRNA Editing: A to I Conversion R-HSA-75064 4.358228e-01 0.361 0 0
C6 deamination of adenosine R-HSA-75102 4.358228e-01 0.361 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 4.358228e-01 0.361 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 4.358228e-01 0.361 0 0
Influenza Virus Induced Apoptosis R-HSA-168277 4.358228e-01 0.361 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 4.358228e-01 0.361 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 4.387772e-01 0.358 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 4.387772e-01 0.358 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 4.387772e-01 0.358 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 4.387772e-01 0.358 0 0
Interleukin-6 signaling R-HSA-1059683 4.387772e-01 0.358 0 0
Processing of SMDT1 R-HSA-8949664 4.387772e-01 0.358 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 4.387772e-01 0.358 0 0
Maturation of nucleoprotein R-HSA-9683610 4.387772e-01 0.358 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.398912e-01 0.357 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.420912e-01 0.354 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 4.455226e-01 0.351 0 0
Potential therapeutics for SARS R-HSA-9679191 4.490376e-01 0.348 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 4.491081e-01 0.348 0 0
Germ layer formation at gastrulation R-HSA-9754189 4.491081e-01 0.348 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 4.491081e-01 0.348 0 0
Rap1 signalling R-HSA-392517 4.491081e-01 0.348 0 0
Ion transport by P-type ATPases R-HSA-936837 4.547316e-01 0.342 0 0
Toll-like Receptor Cascades R-HSA-168898 4.550526e-01 0.342 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 4.556815e-01 0.341 0 0
Long-term potentiation R-HSA-9620244 4.556815e-01 0.341 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 4.556815e-01 0.341 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 4.556815e-01 0.341 0 0
Interleukin-7 signaling R-HSA-1266695 4.556815e-01 0.341 0 0
DNA strand elongation R-HSA-69190 4.603421e-01 0.337 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 4.638743e-01 0.334 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 4.666504e-01 0.331 0 0
Type I hemidesmosome assembly R-HSA-446107 4.666504e-01 0.331 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 4.666504e-01 0.331 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 4.666504e-01 0.331 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 4.666504e-01 0.331 0 0
Hedgehog ligand biogenesis R-HSA-5358346 4.689708e-01 0.329 0 0
Interleukin-1 family signaling R-HSA-446652 4.723643e-01 0.326 0 0
RAF/MAP kinase cascade R-HSA-5673001 4.728299e-01 0.325 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 4.739876e-01 0.324 0 0
Signaling by FGFR4 in disease R-HSA-5655291 4.754638e-01 0.323 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 4.754638e-01 0.323 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 4.799777e-01 0.319 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 4.799777e-01 0.319 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 4.799777e-01 0.319 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 4.799777e-01 0.319 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.799777e-01 0.319 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 4.799777e-01 0.319 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.828416e-01 0.316 0 0
TRP channels R-HSA-3295583 4.828416e-01 0.316 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.828416e-01 0.316 0 0
Cardiogenesis R-HSA-9733709 4.848741e-01 0.314 0 0
Signaling by ALK R-HSA-201556 4.864197e-01 0.313 0 0
Plasma lipoprotein clearance R-HSA-8964043 4.864197e-01 0.313 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.876510e-01 0.312 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.876510e-01 0.312 0 0
RSV-host interactions R-HSA-9833110 4.932824e-01 0.307 0 0
Ion channel transport R-HSA-983712 5.071785e-01 0.295 0 0
Mitochondrial biogenesis R-HSA-1592230 5.072624e-01 0.295 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 5.076056e-01 0.294 0 0
RAB geranylgeranylation R-HSA-8873719 5.079852e-01 0.294 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 5.086826e-01 0.294 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 5.086826e-01 0.294 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 5.086826e-01 0.294 0 0
Diseases of Immune System R-HSA-5260271 5.086826e-01 0.294 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 5.086826e-01 0.294 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 5.095164e-01 0.293 0 0
Cristae formation R-HSA-8949613 5.095164e-01 0.293 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 5.095164e-01 0.293 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 5.095164e-01 0.293 0 0
Lagging Strand Synthesis R-HSA-69186 5.101450e-01 0.292 0 0
ERK/MAPK targets R-HSA-198753 5.101450e-01 0.292 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 5.101450e-01 0.292 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 5.109997e-01 0.292 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.109997e-01 0.292 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 5.109997e-01 0.292 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.109997e-01 0.292 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 5.109997e-01 0.292 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 5.109997e-01 0.292 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 5.109997e-01 0.292 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 5.109997e-01 0.292 0 0
MET activates STAT3 R-HSA-8875791 5.110552e-01 0.292 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 5.110552e-01 0.292 0 0
PLC-gamma1 signalling R-HSA-167021 5.110552e-01 0.292 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 5.110552e-01 0.292 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 5.110552e-01 0.292 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 5.110552e-01 0.292 0 0
Defective DPM2 causes DPM2-CDG R-HSA-4719377 5.110552e-01 0.292 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 5.110552e-01 0.292 0 0
Defective DPM3 causes DPM3-CDG R-HSA-4719360 5.110552e-01 0.292 0 0
Signalling to STAT3 R-HSA-198745 5.110552e-01 0.292 0 0
Defective DPM1 causes DPM1-CDG R-HSA-4717374 5.110552e-01 0.292 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 5.110552e-01 0.292 0 0
MET interacts with TNS proteins R-HSA-8875513 5.110552e-01 0.292 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 5.110552e-01 0.292 0 0
ARMS-mediated activation R-HSA-170984 5.120816e-01 0.291 0 0
MAPK1 (ERK2) activation R-HSA-112411 5.120816e-01 0.291 0 0
Hypusine synthesis from eIF5A-lysine R-HSA-204626 5.120816e-01 0.291 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 5.120816e-01 0.291 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 5.120816e-01 0.291 0 0
Unwinding of DNA R-HSA-176974 5.120816e-01 0.291 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 5.120816e-01 0.291 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 5.120816e-01 0.291 0 0
Regulated proteolysis of p75NTR R-HSA-193692 5.120816e-01 0.291 0 0
Interleukin-1 processing R-HSA-448706 5.120816e-01 0.291 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 5.120816e-01 0.291 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 5.243598e-01 0.280 0 0
Adipogenesis R-HSA-9843745 5.322607e-01 0.274 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 5.327838e-01 0.273 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 5.327838e-01 0.273 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 5.331457e-01 0.273 0 0
Telomere Extension By Telomerase R-HSA-171319 5.356154e-01 0.271 0 0
HIV elongation arrest and recovery R-HSA-167287 5.356154e-01 0.271 0 0
Pausing and recovery of HIV elongation R-HSA-167290 5.356154e-01 0.271 0 0
Inflammasomes R-HSA-622312 5.356154e-01 0.271 0 0
Neutrophil degranulation R-HSA-6798695 5.360044e-01 0.271 0 0
Interleukin-1 signaling R-HSA-9020702 5.360722e-01 0.271 0 0
Mitochondrial calcium ion transport R-HSA-8949215 5.394900e-01 0.268 0 0
Mitochondrial protein import R-HSA-1268020 5.442875e-01 0.264 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 5.452198e-01 0.263 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.452198e-01 0.263 0 0
Killing mechanisms R-HSA-9664420 5.452198e-01 0.263 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.452198e-01 0.263 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 5.452198e-01 0.263 0 0
Activation of SMO R-HSA-5635838 5.452198e-01 0.263 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 5.452198e-01 0.263 0 0
Antigen processing-Cross presentation R-HSA-1236975 5.489108e-01 0.260 0 0
NGF-stimulated transcription R-HSA-9031628 5.490173e-01 0.260 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 5.521362e-01 0.258 0 0
HIV Transcription Initiation R-HSA-167161 5.521362e-01 0.258 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 5.521362e-01 0.258 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 5.521362e-01 0.258 0 0
Intra-Golgi traffic R-HSA-6811438 5.521362e-01 0.258 0 0
Binding and entry of HIV virion R-HSA-173107 5.548844e-01 0.256 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 5.548844e-01 0.256 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 5.548844e-01 0.256 0 0
DNA replication initiation R-HSA-68952 5.548844e-01 0.256 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 5.548844e-01 0.256 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 5.548844e-01 0.256 0 0
Interleukin-27 signaling R-HSA-9020956 5.548844e-01 0.256 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 5.548844e-01 0.256 0 0
Receptor Mediated Mitophagy R-HSA-8934903 5.548844e-01 0.256 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 5.548844e-01 0.256 0 0
Tandem pore domain potassium channels R-HSA-1296346 5.548844e-01 0.256 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 5.651501e-01 0.248 0 0
Protein localization R-HSA-9609507 5.652094e-01 0.248 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.661262e-01 0.247 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 5.679130e-01 0.246 0 0
Signaling by KIT in disease R-HSA-9669938 5.679130e-01 0.246 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 5.732274e-01 0.242 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 5.762593e-01 0.239 0 0
HCN channels R-HSA-1296061 5.762593e-01 0.239 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 5.762593e-01 0.239 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.762593e-01 0.239 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 5.762593e-01 0.239 0 0
Defective MAT1A causes MATD R-HSA-5579024 5.762593e-01 0.239 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.762593e-01 0.239 0 0
Signaling by MAP2K mutants R-HSA-9652169 5.762593e-01 0.239 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 5.762593e-01 0.239 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 5.762593e-01 0.239 0 0
Regulation of gap junction activity R-HSA-191650 5.762593e-01 0.239 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 5.762593e-01 0.239 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 5.762593e-01 0.239 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.762593e-01 0.239 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.762593e-01 0.239 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 5.779992e-01 0.238 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 5.779992e-01 0.238 0 0
GPVI-mediated activation cascade R-HSA-114604 5.787183e-01 0.238 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 5.835167e-01 0.234 0 0
Activation of BH3-only proteins R-HSA-114452 5.857826e-01 0.232 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 5.938376e-01 0.226 0 0
Signaling by SCF-KIT R-HSA-1433557 5.938376e-01 0.226 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 5.949518e-01 0.226 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 5.949518e-01 0.226 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 5.949518e-01 0.226 0 0
Formation of the posterior neural plate R-HSA-9832991 5.949518e-01 0.226 0 0
Synthesis of PI R-HSA-1483226 5.949518e-01 0.226 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 5.949518e-01 0.226 0 0
Signaling by APC mutants R-HSA-4839744 5.949518e-01 0.226 0 0
vRNP Assembly R-HSA-192905 5.949518e-01 0.226 0 0
Bicarbonate transporters R-HSA-425381 5.949518e-01 0.226 0 0
Interleukin receptor SHC signaling R-HSA-912526 5.953336e-01 0.225 0 0
Growth hormone receptor signaling R-HSA-982772 5.953336e-01 0.225 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.953336e-01 0.225 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 5.953336e-01 0.225 0 0
Adaptive Immune System R-HSA-1280218 6.001737e-01 0.222 0 0
Signaling by FGFR2 R-HSA-5654738 6.045379e-01 0.219 0 0
Ca2+ pathway R-HSA-4086398 6.087538e-01 0.216 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.092491e-01 0.215 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.092491e-01 0.215 0 0
Uptake and function of anthrax toxins R-HSA-5210891 6.092491e-01 0.215 0 0
Downstream signal transduction R-HSA-186763 6.097279e-01 0.215 0 0
Peroxisomal protein import R-HSA-9033241 6.191324e-01 0.208 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.191324e-01 0.208 0 0
Regulation of beta-cell development R-HSA-186712 6.191324e-01 0.208 0 0
Thromboxane signalling through TP receptor R-HSA-428930 6.216894e-01 0.206 0 0
Interleukin-6 family signaling R-HSA-6783589 6.216894e-01 0.206 0 0
MET promotes cell motility R-HSA-8875878 6.222605e-01 0.206 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 6.222605e-01 0.206 0 0
Signaling by FGFR in disease R-HSA-1226099 6.245971e-01 0.204 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 6.256636e-01 0.204 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.256636e-01 0.204 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 6.256636e-01 0.204 0 0
Anchoring fibril formation R-HSA-2214320 6.322523e-01 0.199 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 6.322523e-01 0.199 0 0
Signaling by AMER1 mutants R-HSA-4839748 6.322523e-01 0.199 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 6.322523e-01 0.199 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 6.322523e-01 0.199 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 6.327712e-01 0.199 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 6.327712e-01 0.199 0 0
G2 Phase R-HSA-68911 6.327712e-01 0.199 0 0
NTRK2 activates RAC1 R-HSA-9032759 6.327712e-01 0.199 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.327712e-01 0.199 0 0
Defective F9 activation R-HSA-9673221 6.327712e-01 0.199 0 0
PTK6 Activates STAT3 R-HSA-8849474 6.327712e-01 0.199 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.327712e-01 0.199 0 0
Inositol transporters R-HSA-429593 6.327712e-01 0.199 0 0
Reelin signalling pathway R-HSA-8866376 6.327712e-01 0.199 0 0
NrCAM interactions R-HSA-447038 6.327712e-01 0.199 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 6.327712e-01 0.199 0 0
Signaling by WNT in cancer R-HSA-4791275 6.328504e-01 0.199 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 6.334734e-01 0.198 0 0
Fanconi Anemia Pathway R-HSA-6783310 6.334734e-01 0.198 0 0
Mismatch Repair R-HSA-5358508 6.389116e-01 0.195 0 0
Synaptic adhesion-like molecules R-HSA-8849932 6.389116e-01 0.195 0 0
Apoptotic factor-mediated response R-HSA-111471 6.389116e-01 0.195 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.389116e-01 0.195 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 6.389116e-01 0.195 0 0
Tie2 Signaling R-HSA-210993 6.389116e-01 0.195 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 6.436848e-01 0.191 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 6.469342e-01 0.189 0 0
Integrin signaling R-HSA-354192 6.551147e-01 0.184 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 6.551147e-01 0.184 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 6.551147e-01 0.184 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 6.551147e-01 0.184 0 0
Downstream TCR signaling R-HSA-202424 6.582100e-01 0.182 0 0
Interleukin-2 family signaling R-HSA-451927 6.631088e-01 0.178 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 6.664438e-01 0.176 0 0
Repression of WNT target genes R-HSA-4641265 6.668110e-01 0.176 0 0
GRB2 events in EGFR signaling R-HSA-179812 6.668110e-01 0.176 0 0
Interleukin-35 Signalling R-HSA-8984722 6.668110e-01 0.176 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 6.668110e-01 0.176 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 6.668110e-01 0.176 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 6.668110e-01 0.176 0 0
Interleukin-15 signaling R-HSA-8983432 6.668110e-01 0.176 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 6.668110e-01 0.176 0 0
Maturation of nucleoprotein R-HSA-9694631 6.669560e-01 0.176 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.669560e-01 0.176 0 0
NCAM signaling for neurite out-growth R-HSA-375165 6.694187e-01 0.174 0 0
Resolution of D-Loop Structures R-HSA-5693537 6.764946e-01 0.170 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 6.764946e-01 0.170 0 0
Plus-strand DNA synthesis R-HSA-164525 6.817493e-01 0.166 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 6.817493e-01 0.166 0 0
Cam-PDE 1 activation R-HSA-111957 6.817493e-01 0.166 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.817493e-01 0.166 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.817493e-01 0.166 0 0
Phosphorylation of Emi1 R-HSA-176417 6.817493e-01 0.166 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.817493e-01 0.166 0 0
Signaling by MAPK mutants R-HSA-9652817 6.817493e-01 0.166 0 0
Terminal pathway of complement R-HSA-166665 6.817493e-01 0.166 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 6.817493e-01 0.166 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.817493e-01 0.166 0 0
Synthesis of dolichyl-phosphate mannose R-HSA-162699 6.817493e-01 0.166 0 0
Threonine catabolism R-HSA-8849175 6.817493e-01 0.166 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.817493e-01 0.166 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.817493e-01 0.166 0 0
Intestinal hexose absorption R-HSA-8981373 6.817493e-01 0.166 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 6.817493e-01 0.166 0 0
Relaxin receptors R-HSA-444821 6.817493e-01 0.166 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.817493e-01 0.166 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 6.817493e-01 0.166 0 0
Selenoamino acid metabolism R-HSA-2408522 6.830420e-01 0.166 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 6.852728e-01 0.164 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 6.933743e-01 0.159 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.933743e-01 0.159 0 0
Signaling by NODAL R-HSA-1181150 6.933743e-01 0.159 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 6.939791e-01 0.159 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 6.939791e-01 0.159 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 6.939791e-01 0.159 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 6.939791e-01 0.159 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 6.969725e-01 0.157 0 0
Calnexin/calreticulin cycle R-HSA-901042 6.969725e-01 0.157 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 6.985541e-01 0.156 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 6.986959e-01 0.156 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 6.986959e-01 0.156 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 6.986959e-01 0.156 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 6.986959e-01 0.156 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 6.986959e-01 0.156 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 7.000492e-01 0.155 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 7.047989e-01 0.152 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 7.056953e-01 0.151 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.098487e-01 0.149 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.119394e-01 0.148 0 0
SLC transporter disorders R-HSA-5619102 7.119759e-01 0.148 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 7.122110e-01 0.147 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 7.157547e-01 0.145 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.157547e-01 0.145 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 7.231364e-01 0.141 0 0
Metabolism of ingested MeSeO2H into MeSeH R-HSA-5263617 7.241975e-01 0.140 0 0
Uncoating of the HIV Virion R-HSA-162585 7.241975e-01 0.140 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 7.241975e-01 0.140 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 7.241975e-01 0.140 0 0
CREB phosphorylation R-HSA-199920 7.241975e-01 0.140 0 0
G2/M DNA replication checkpoint R-HSA-69478 7.241975e-01 0.140 0 0
Neurofascin interactions R-HSA-447043 7.241975e-01 0.140 0 0
Hydrolysis of LPE R-HSA-1483152 7.241975e-01 0.140 0 0
Lactose synthesis R-HSA-5653890 7.241975e-01 0.140 0 0
VLDL assembly R-HSA-8866423 7.241975e-01 0.140 0 0
HDL clearance R-HSA-8964011 7.241975e-01 0.140 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 7.259310e-01 0.139 0 0
Prolactin receptor signaling R-HSA-1170546 7.280053e-01 0.138 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 7.280053e-01 0.138 0 0
Removal of the Flap Intermediate R-HSA-69166 7.280053e-01 0.138 0 0
Retrograde neurotrophin signalling R-HSA-177504 7.280053e-01 0.138 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 7.280053e-01 0.138 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 7.280053e-01 0.138 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 7.283615e-01 0.138 0 0
Developmental Cell Lineages R-HSA-9734767 7.315312e-01 0.136 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 7.354194e-01 0.133 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 7.363677e-01 0.133 0 0
DARPP-32 events R-HSA-180024 7.363677e-01 0.133 0 0
Platelet calcium homeostasis R-HSA-418360 7.363677e-01 0.133 0 0
Regulation of gene expression in beta cells R-HSA-210745 7.363677e-01 0.133 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 7.413932e-01 0.130 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 7.452962e-01 0.128 0 0
DAP12 interactions R-HSA-2172127 7.523872e-01 0.124 0 0
Collagen chain trimerization R-HSA-8948216 7.529293e-01 0.123 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 7.548589e-01 0.122 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 7.548589e-01 0.122 0 0
SHC1 events in EGFR signaling R-HSA-180336 7.548589e-01 0.122 0 0
G beta:gamma signalling through BTK R-HSA-8964315 7.548589e-01 0.122 0 0
Telomere C-strand synthesis initiation R-HSA-174430 7.548589e-01 0.122 0 0
Signaling by Activin R-HSA-1502540 7.548589e-01 0.122 0 0
Other semaphorin interactions R-HSA-416700 7.548589e-01 0.122 0 0
Biotin transport and metabolism R-HSA-196780 7.548589e-01 0.122 0 0
Formation of the anterior neural plate R-HSA-9823739 7.548589e-01 0.122 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.558307e-01 0.122 0 0
DAG1 core M1 glycosylations R-HSA-8932506 7.609861e-01 0.119 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 7.609861e-01 0.119 0 0
Disinhibition of SNARE formation R-HSA-114516 7.609861e-01 0.119 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.609861e-01 0.119 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 7.609861e-01 0.119 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 7.609861e-01 0.119 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 7.609861e-01 0.119 0 0
VLDL clearance R-HSA-8964046 7.609861e-01 0.119 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 7.609861e-01 0.119 0 0
Ca2+ activated K+ channels R-HSA-1296052 7.609861e-01 0.119 0 0
LDL remodeling R-HSA-8964041 7.609861e-01 0.119 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 7.609861e-01 0.119 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 7.609861e-01 0.119 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 7.609861e-01 0.119 0 0
FGFR2 alternative splicing R-HSA-6803529 7.630602e-01 0.117 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.630602e-01 0.117 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.630602e-01 0.117 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.630602e-01 0.117 0 0
PLC beta mediated events R-HSA-112043 7.686458e-01 0.114 0 0
Translation R-HSA-72766 7.688726e-01 0.114 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.741640e-01 0.111 0 0
Disorders of transmembrane transporters R-HSA-5619115 7.753233e-01 0.111 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 7.793902e-01 0.108 0 0
Phase 4 - resting membrane potential R-HSA-5576886 7.793902e-01 0.108 0 0
Differentiation of T cells R-HSA-9945266 7.793902e-01 0.108 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 7.793902e-01 0.108 0 0
Signaling by FGFR R-HSA-190236 7.796647e-01 0.108 0 0
Signaling by PDGF R-HSA-186797 7.817634e-01 0.107 0 0
COPII-mediated vesicle transport R-HSA-204005 7.825772e-01 0.106 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 7.832284e-01 0.106 0 0
ABC transporter disorders R-HSA-5619084 7.839364e-01 0.106 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 7.857135e-01 0.105 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 7.857135e-01 0.105 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.857135e-01 0.105 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 7.913942e-01 0.102 0 0
Reverse Transcription of HIV RNA R-HSA-162589 7.928695e-01 0.101 0 0
Minus-strand DNA synthesis R-HSA-164516 7.928695e-01 0.101 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.928695e-01 0.101 0 0
DAG1 core M2 glycosylations R-HSA-8932504 7.928695e-01 0.101 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 7.928695e-01 0.101 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.928695e-01 0.101 0 0
Regulation by c-FLIP R-HSA-3371378 7.928695e-01 0.101 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.928695e-01 0.101 0 0
Co-stimulation by ICOS R-HSA-9927354 7.928695e-01 0.101 0 0
Interleukin-9 signaling R-HSA-8985947 7.928695e-01 0.101 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.928695e-01 0.101 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 7.928695e-01 0.101 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 7.928695e-01 0.101 0 0
SLC-mediated bile acid transport R-HSA-9958517 7.928695e-01 0.101 0 0
Dimerization of procaspase-8 R-HSA-69416 7.928695e-01 0.101 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.928695e-01 0.101 0 0
Intestinal absorption R-HSA-8963676 7.928695e-01 0.101 0 0
Hemostasis R-HSA-109582 7.953959e-01 0.099 0 0
HIV Transcription Elongation R-HSA-167169 8.007894e-01 0.096 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 8.007894e-01 0.096 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 8.007894e-01 0.096 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 8.017410e-01 0.096 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 8.017410e-01 0.096 0 0
Synthesis of PG R-HSA-1483148 8.017410e-01 0.096 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 8.017410e-01 0.096 0 0
Fibronectin matrix formation R-HSA-1566977 8.017410e-01 0.096 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 8.017410e-01 0.096 0 0
Response to metal ions R-HSA-5660526 8.017410e-01 0.096 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.051696e-01 0.094 0 0
G-protein beta:gamma signalling R-HSA-397795 8.075530e-01 0.093 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 8.075530e-01 0.093 0 0
Post-translational protein modification R-HSA-597592 8.092913e-01 0.092 0 0
PI Metabolism R-HSA-1483255 8.186800e-01 0.087 0 0
Tight junction interactions R-HSA-420029 8.193033e-01 0.087 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 8.193033e-01 0.087 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.193033e-01 0.087 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 8.205013e-01 0.086 0 0
CASP8 activity is inhibited R-HSA-5218900 8.205013e-01 0.086 0 0
Interleukin-21 signaling R-HSA-9020958 8.205013e-01 0.086 0 0
p75NTR regulates axonogenesis R-HSA-193697 8.205013e-01 0.086 0 0
mRNA Editing R-HSA-75072 8.205013e-01 0.086 0 0
Regulation of signaling by NODAL R-HSA-1433617 8.205013e-01 0.086 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 8.205013e-01 0.086 0 0
Lysosomal oligosaccharide catabolism R-HSA-8853383 8.205013e-01 0.086 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.205013e-01 0.086 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 8.205013e-01 0.086 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 8.220563e-01 0.085 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 8.220563e-01 0.085 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.220563e-01 0.085 0 0
Specification of primordial germ cells R-HSA-9827857 8.220563e-01 0.085 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.220563e-01 0.085 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.226762e-01 0.085 0 0
MET activates PTK2 signaling R-HSA-8874081 8.353396e-01 0.078 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.353396e-01 0.078 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.362485e-01 0.078 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 8.362644e-01 0.078 0 0
Signal amplification R-HSA-392518 8.368028e-01 0.077 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.368028e-01 0.077 0 0
G-protein mediated events R-HSA-112040 8.391852e-01 0.076 0 0
GAB1 signalosome R-HSA-180292 8.404814e-01 0.075 0 0
Polo-like kinase mediated events R-HSA-156711 8.404814e-01 0.075 0 0
PKA activation R-HSA-163615 8.404814e-01 0.075 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 8.404814e-01 0.075 0 0
PKA activation in glucagon signalling R-HSA-164378 8.404814e-01 0.075 0 0
Nephron development R-HSA-9831926 8.404814e-01 0.075 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.420937e-01 0.075 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 8.444483e-01 0.073 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 8.444483e-01 0.073 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.444483e-01 0.073 0 0
Maturation of spike protein R-HSA-9683686 8.444483e-01 0.073 0 0
MAPK3 (ERK1) activation R-HSA-110056 8.444483e-01 0.073 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 8.444483e-01 0.073 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.444483e-01 0.073 0 0
Regulation of the apoptosome activity R-HSA-9627069 8.444483e-01 0.073 0 0
Formation of apoptosome R-HSA-111458 8.444483e-01 0.073 0 0
Regulated Necrosis R-HSA-5218859 8.491024e-01 0.071 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.501334e-01 0.071 0 0
Post-translational protein phosphorylation R-HSA-8957275 8.525286e-01 0.069 0 0
Immune System R-HSA-168256 8.537635e-01 0.069 0 0
Translation of Structural Proteins R-HSA-9694635 8.559676e-01 0.068 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 8.571589e-01 0.067 0 0
E2F mediated regulation of DNA replication R-HSA-113510 8.571589e-01 0.067 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 8.571589e-01 0.067 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 8.571589e-01 0.067 0 0
Other interleukin signaling R-HSA-449836 8.571589e-01 0.067 0 0
Specification of the neural plate border R-HSA-9834899 8.571589e-01 0.067 0 0
Diseases of hemostasis R-HSA-9671793 8.571589e-01 0.067 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.571589e-01 0.067 0 0
Formation of paraxial mesoderm R-HSA-9793380 8.621593e-01 0.064 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.622337e-01 0.064 0 0
Amine ligand-binding receptors R-HSA-375280 8.639262e-01 0.064 0 0
DAG1 core M3 glycosylations R-HSA-8932505 8.652018e-01 0.063 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 8.652018e-01 0.063 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 8.652018e-01 0.063 0 0
Chylomicron assembly R-HSA-8963888 8.652018e-01 0.063 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.652018e-01 0.063 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.652018e-01 0.063 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.652018e-01 0.063 0 0
Prostanoid ligand receptors R-HSA-391908 8.652018e-01 0.063 0 0
Interleukin-2 signaling R-HSA-9020558 8.652018e-01 0.063 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.652018e-01 0.063 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.655359e-01 0.063 0 0
Gastrulation R-HSA-9758941 8.686046e-01 0.061 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 8.722270e-01 0.059 0 0
Protein hydroxylation R-HSA-9629569 8.722270e-01 0.059 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.736252e-01 0.059 0 0
Somitogenesis R-HSA-9824272 8.743007e-01 0.058 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.751635e-01 0.058 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.762744e-01 0.057 0 0
Pyruvate metabolism R-HSA-70268 8.782134e-01 0.056 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 8.798079e-01 0.056 0 0
ERKs are inactivated R-HSA-202670 8.831874e-01 0.054 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.831874e-01 0.054 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 8.831874e-01 0.054 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.831874e-01 0.054 0 0
Plasmalogen biosynthesis R-HSA-75896 8.831874e-01 0.054 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.831874e-01 0.054 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.831874e-01 0.054 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 8.839687e-01 0.054 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 8.839956e-01 0.054 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.839956e-01 0.054 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.839956e-01 0.054 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 8.841933e-01 0.053 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.858184e-01 0.053 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 8.858184e-01 0.053 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 8.858184e-01 0.053 0 0
Signalling to RAS R-HSA-167044 8.858184e-01 0.053 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 8.858184e-01 0.053 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.877619e-01 0.052 0 0
RAS processing R-HSA-9648002 8.939826e-01 0.049 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.980586e-01 0.047 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 8.980586e-01 0.047 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 8.980586e-01 0.047 0 0
Attachment and Entry R-HSA-9694614 8.980586e-01 0.047 0 0
Serine metabolism R-HSA-977347 8.980586e-01 0.047 0 0
Ribavirin ADME R-HSA-9755088 8.980586e-01 0.047 0 0
Cargo concentration in the ER R-HSA-5694530 8.982854e-01 0.047 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.982854e-01 0.047 0 0
MET activates RAS signaling R-HSA-8851805 8.987741e-01 0.046 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.987741e-01 0.046 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.987741e-01 0.046 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.987741e-01 0.046 0 0
Maple Syrup Urine Disease R-HSA-9865114 8.987741e-01 0.046 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.987741e-01 0.046 0 0
OAS antiviral response R-HSA-8983711 8.987741e-01 0.046 0 0
Co-stimulation by CD28 R-HSA-389356 9.014737e-01 0.045 0 0
Iron uptake and transport R-HSA-917937 9.054950e-01 0.043 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.068358e-01 0.042 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.079114e-01 0.042 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 9.090663e-01 0.041 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.090663e-01 0.041 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.090663e-01 0.041 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.090663e-01 0.041 0 0
LDL clearance R-HSA-8964038 9.090663e-01 0.041 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 9.090663e-01 0.041 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 9.122819e-01 0.040 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 9.122819e-01 0.040 0 0
FGFR1c ligand binding and activation R-HSA-190373 9.122819e-01 0.040 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 9.122819e-01 0.040 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.178816e-01 0.037 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.189524e-01 0.037 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.189524e-01 0.037 0 0
Interleukin-20 family signaling R-HSA-8854691 9.189524e-01 0.037 0 0
Biosynthesis of maresins R-HSA-9018682 9.189524e-01 0.037 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.218968e-01 0.035 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.234804e-01 0.035 0 0
Integrin cell surface interactions R-HSA-216083 9.235337e-01 0.035 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 9.239878e-01 0.034 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 9.239878e-01 0.034 0 0
Physiological factors R-HSA-5578768 9.239878e-01 0.034 0 0
Hydrolysis of LPC R-HSA-1483115 9.239878e-01 0.034 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.239878e-01 0.034 0 0
Malate-aspartate shuttle R-HSA-9856872 9.239878e-01 0.034 0 0
HDL assembly R-HSA-8963896 9.239878e-01 0.034 0 0
Zinc transporters R-HSA-435354 9.239878e-01 0.034 0 0
Interferon alpha/beta signaling R-HSA-909733 9.247237e-01 0.034 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.247238e-01 0.034 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.247238e-01 0.034 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.247238e-01 0.034 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.262228e-01 0.033 0 0
Mitochondrial protein degradation R-HSA-9837999 9.268160e-01 0.033 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.278200e-01 0.033 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.278200e-01 0.033 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.278200e-01 0.033 0 0
Infectious disease R-HSA-5663205 9.278792e-01 0.033 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.283527e-01 0.032 0 0
ECM proteoglycans R-HSA-3000178 9.334827e-01 0.030 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.341321e-01 0.030 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 9.341321e-01 0.030 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.341321e-01 0.030 0 0
p38MAPK events R-HSA-171007 9.341321e-01 0.030 0 0
DNA Damage Reversal R-HSA-73942 9.341321e-01 0.030 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.354802e-01 0.029 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.357650e-01 0.029 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.357650e-01 0.029 0 0
Laminin interactions R-HSA-3000157 9.357650e-01 0.029 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.357650e-01 0.029 0 0
Leishmania phagocytosis R-HSA-9664417 9.365898e-01 0.028 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.365898e-01 0.028 0 0
Parasite infection R-HSA-9664407 9.365898e-01 0.028 0 0
Opioid Signalling R-HSA-111885 9.374829e-01 0.028 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.386774e-01 0.027 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.386774e-01 0.027 0 0
Proteasome assembly R-HSA-9907900 9.387720e-01 0.027 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.413828e-01 0.026 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.428756e-01 0.026 0 0
Sphingolipid catabolism R-HSA-9845614 9.428756e-01 0.026 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 9.428756e-01 0.026 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.428756e-01 0.026 0 0
Atorvastatin ADME R-HSA-9754706 9.429232e-01 0.026 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 9.429232e-01 0.026 0 0
Fructose catabolism R-HSA-70350 9.429232e-01 0.026 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 9.429232e-01 0.026 0 0
Attachment and Entry R-HSA-9678110 9.429232e-01 0.026 0 0
IGF1R signaling cascade R-HSA-2428924 9.438857e-01 0.025 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.442888e-01 0.025 0 0
Triglyceride catabolism R-HSA-163560 9.447186e-01 0.025 0 0
G alpha (z) signalling events R-HSA-418597 9.458343e-01 0.024 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.483502e-01 0.023 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 9.492329e-01 0.023 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 9.492329e-01 0.023 0 0
Insulin processing R-HSA-264876 9.492329e-01 0.023 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.492329e-01 0.023 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.492329e-01 0.023 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.498176e-01 0.022 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.502028e-01 0.022 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.502028e-01 0.022 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 9.505414e-01 0.022 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.505414e-01 0.022 0 0
Heme assimilation R-HSA-9927020 9.505414e-01 0.022 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 9.505414e-01 0.022 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 9.505414e-01 0.022 0 0
Galactose catabolism R-HSA-70370 9.505414e-01 0.022 0 0
Coenzyme A biosynthesis R-HSA-196783 9.505414e-01 0.022 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.505414e-01 0.022 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.505414e-01 0.022 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.524927e-01 0.021 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.543611e-01 0.020 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.543611e-01 0.020 0 0
IRS-mediated signalling R-HSA-112399 9.546610e-01 0.020 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 9.549113e-01 0.020 0 0
Formation of the Early Elongation Complex R-HSA-113418 9.549113e-01 0.020 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.549113e-01 0.020 0 0
Elastic fibre formation R-HSA-1566948 9.551759e-01 0.020 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.551759e-01 0.020 0 0
Transmission across Chemical Synapses R-HSA-112315 9.570767e-01 0.019 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.571431e-01 0.019 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 9.571431e-01 0.019 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 9.571431e-01 0.019 0 0
Catecholamine biosynthesis R-HSA-209905 9.571431e-01 0.019 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.571431e-01 0.019 0 0
Choline catabolism R-HSA-6798163 9.571431e-01 0.019 0 0
Cardiac conduction R-HSA-5576891 9.579313e-01 0.019 0 0
Metal ion SLC transporters R-HSA-425410 9.582215e-01 0.019 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.585634e-01 0.018 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.596810e-01 0.018 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.598894e-01 0.018 0 0
mRNA Capping R-HSA-72086 9.599788e-01 0.018 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.599788e-01 0.018 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.628640e-01 0.016 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.628640e-01 0.016 0 0
Platelet sensitization by LDL R-HSA-432142 9.628640e-01 0.016 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.628640e-01 0.016 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.628640e-01 0.016 0 0
Neuronal System R-HSA-112316 9.641353e-01 0.016 0 0
Neurotransmitter clearance R-HSA-112311 9.644972e-01 0.016 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.654602e-01 0.015 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.656379e-01 0.015 0 0
Azathioprine ADME R-HSA-9748787 9.656379e-01 0.015 0 0
PI3K Cascade R-HSA-109704 9.656379e-01 0.015 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.678215e-01 0.014 0 0
Crosslinking of collagen fibrils R-HSA-2243919 9.678215e-01 0.014 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 9.678215e-01 0.014 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.678215e-01 0.014 0 0
Pyrimidine biosynthesis R-HSA-500753 9.678215e-01 0.014 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.678215e-01 0.014 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.678215e-01 0.014 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.721066e-01 0.012 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.721174e-01 0.012 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.721174e-01 0.012 0 0
Co-inhibition by CTLA4 R-HSA-389513 9.721174e-01 0.012 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.721174e-01 0.012 0 0
Creatine metabolism R-HSA-71288 9.721174e-01 0.012 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.721174e-01 0.012 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.721174e-01 0.012 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.737803e-01 0.012 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.740213e-01 0.011 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.752948e-01 0.011 0 0
Neddylation R-HSA-8951664 9.755353e-01 0.011 0 0
PPARA activates gene expression R-HSA-1989781 9.757061e-01 0.011 0 0
G-protein activation R-HSA-202040 9.758400e-01 0.011 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 9.758400e-01 0.011 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.758400e-01 0.011 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.758400e-01 0.011 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.758400e-01 0.011 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.758400e-01 0.011 0 0
Insulin receptor signalling cascade R-HSA-74751 9.761862e-01 0.010 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.781292e-01 0.010 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.790658e-01 0.009 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.790658e-01 0.009 0 0
Androgen biosynthesis R-HSA-193048 9.790658e-01 0.009 0 0
RA biosynthesis pathway R-HSA-5365859 9.806473e-01 0.008 0 0
Collagen formation R-HSA-1474290 9.809957e-01 0.008 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.811328e-01 0.008 0 0
Interferon gamma signaling R-HSA-877300 9.812102e-01 0.008 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.818611e-01 0.008 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.818611e-01 0.008 0 0
Free fatty acid receptors R-HSA-444209 9.818611e-01 0.008 0 0
Cellular hexose transport R-HSA-189200 9.818611e-01 0.008 0 0
Fructose metabolism R-HSA-5652084 9.818611e-01 0.008 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.818611e-01 0.008 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.842833e-01 0.007 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.842833e-01 0.007 0 0
Carnitine shuttle R-HSA-200425 9.842833e-01 0.007 0 0
Formation of the ureteric bud R-HSA-9830674 9.842833e-01 0.007 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.847691e-01 0.007 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.848670e-01 0.007 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.848910e-01 0.007 0 0
Disease R-HSA-1643685 9.859886e-01 0.006 0 0
CYP2E1 reactions R-HSA-211999 9.863821e-01 0.006 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.863821e-01 0.006 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.863821e-01 0.006 0 0
Complex III assembly R-HSA-9865881 9.863821e-01 0.006 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.863821e-01 0.006 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.863821e-01 0.006 0 0
GPER1 signaling R-HSA-9634597 9.864898e-01 0.006 0 0
NCAM1 interactions R-HSA-419037 9.866264e-01 0.006 0 0
Regulation of insulin secretion R-HSA-422356 9.874984e-01 0.005 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.875397e-01 0.005 0 0
Metabolism of polyamines R-HSA-351202 9.875397e-01 0.005 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.881860e-01 0.005 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.882008e-01 0.005 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.882008e-01 0.005 0 0
G protein gated Potassium channels R-HSA-1296059 9.882008e-01 0.005 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.882008e-01 0.005 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.882008e-01 0.005 0 0
Hyaluronan degradation R-HSA-2160916 9.882008e-01 0.005 0 0
Formation of the nephric duct R-HSA-9830364 9.882008e-01 0.005 0 0
Retinoid cycle disease events R-HSA-2453864 9.882008e-01 0.005 0 0
Diseases of the neuronal system R-HSA-9675143 9.882008e-01 0.005 0 0
Diseases associated with visual transduction R-HSA-2474795 9.882008e-01 0.005 0 0
Aquaporin-mediated transport R-HSA-445717 9.887760e-01 0.005 0 0
Collagen degradation R-HSA-1442490 9.887760e-01 0.005 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.895676e-01 0.005 0 0
Pentose phosphate pathway R-HSA-71336 9.895676e-01 0.005 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.897767e-01 0.004 0 0
Urea cycle R-HSA-70635 9.897767e-01 0.004 0 0
Linoleic acid (LA) metabolism R-HSA-2046105 9.897767e-01 0.004 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.897767e-01 0.004 0 0
Complex IV assembly R-HSA-9864848 9.903687e-01 0.004 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.911421e-01 0.004 0 0
Signaling by BMP R-HSA-201451 9.911421e-01 0.004 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.911421e-01 0.004 0 0
Maturation of spike protein R-HSA-9694548 9.918738e-01 0.004 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.919678e-01 0.004 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.923253e-01 0.003 0 0
Pyrimidine salvage R-HSA-73614 9.923253e-01 0.003 0 0
Prednisone ADME R-HSA-9757110 9.923253e-01 0.003 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.928317e-01 0.003 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.928317e-01 0.003 0 0
Glucagon-type ligand receptors R-HSA-420092 9.933505e-01 0.003 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.936788e-01 0.003 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.940641e-01 0.003 0 0
Kidney development R-HSA-9830369 9.940641e-01 0.003 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.940894e-01 0.003 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.942388e-01 0.003 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.942388e-01 0.003 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.942388e-01 0.003 0 0
Leishmania infection R-HSA-9658195 9.944004e-01 0.002 0 0
Parasitic Infection Pathways R-HSA-9824443 9.944004e-01 0.002 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.944275e-01 0.002 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.950085e-01 0.002 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.950085e-01 0.002 0 0
Methylation R-HSA-156581 9.950891e-01 0.002 0 0
DAG1 glycosylations R-HSA-8931838 9.956754e-01 0.002 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.957091e-01 0.002 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.961265e-01 0.002 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.961677e-01 0.002 0 0
Triglyceride metabolism R-HSA-8979227 9.961677e-01 0.002 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.961893e-01 0.002 0 0
Integration of energy metabolism R-HSA-163685 9.963456e-01 0.002 0 0
tRNA Aminoacylation R-HSA-379724 9.965907e-01 0.001 0 0
Synthesis of PC R-HSA-1483191 9.966446e-01 0.001 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.967538e-01 0.001 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.967538e-01 0.001 0 0
Heme degradation R-HSA-189483 9.967538e-01 0.001 0 0
Metabolism of proteins R-HSA-392499 9.968611e-01 0.001 0 0
eNOS activation R-HSA-203615 9.971876e-01 0.001 0 0
Hyaluronan metabolism R-HSA-2142845 9.971876e-01 0.001 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.971876e-01 0.001 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.971876e-01 0.001 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.971876e-01 0.001 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.974005e-01 0.001 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.975634e-01 0.001 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.975634e-01 0.001 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.975634e-01 0.001 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.975634e-01 0.001 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.975634e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.976045e-01 0.001 0 0
Potassium Channels R-HSA-1296071 9.978022e-01 0.001 0 0
Glycosphingolipid transport R-HSA-9845576 9.978891e-01 0.001 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.978891e-01 0.001 0 0
The phototransduction cascade R-HSA-2514856 9.979882e-01 0.001 0 0
Metabolism of folate and pterines R-HSA-196757 9.981712e-01 0.001 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.983307e-01 0.001 0 0
Purine salvage R-HSA-74217 9.984156e-01 0.001 0 0
Neurotransmitter release cycle R-HSA-112310 9.984384e-01 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 9.984446e-01 0.001 0 0
Paracetamol ADME R-HSA-9753281 9.987984e-01 0.001 0 0
Tryptophan catabolism R-HSA-71240 9.988109e-01 0.001 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.988109e-01 0.001 0 0
Signaling by Insulin receptor R-HSA-74752 9.988673e-01 0.000 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.989698e-01 0.000 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.989698e-01 0.000 0 0
Synthesis of PA R-HSA-1483166 9.990726e-01 0.000 0 0
Activation of GABAB receptors R-HSA-991365 9.992269e-01 0.000 0 0
GABA B receptor activation R-HSA-977444 9.992269e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.992560e-01 0.000 0 0
Platelet homeostasis R-HSA-418346 9.992888e-01 0.000 0 0
Pyrimidine catabolism R-HSA-73621 9.993302e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.993594e-01 0.000 0 0
Surfactant metabolism R-HSA-5683826 9.994198e-01 0.000 0 0
The canonical retinoid cycle in rods (twilight vision) R-HSA-2453902 9.994974e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.995409e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.995889e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.996062e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.996062e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.996277e-01 0.000 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.996733e-01 0.000 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.997462e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.997489e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.997489e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.997548e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.997636e-01 0.000 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.997876e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.997876e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.997968e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.998117e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.998518e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.998518e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.998701e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.998862e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.998881e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.998891e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.998964e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.998967e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.999003e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.999103e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.999168e-01 0.000 0 0
GABA receptor activation R-HSA-977443 9.999417e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.999441e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999494e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.999495e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.999527e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999607e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999607e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999621e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999712e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.999787e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999803e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999844e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999862e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.999880e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.999880e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.999880e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999897e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999911e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.999922e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.999956e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999957e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999962e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999972e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999974e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999981e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999982e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999983e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999986e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999988e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999990e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999992e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999994e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999996e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999997e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999998e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999998e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999998e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999998e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999998e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999998e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999998e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999999e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999999e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 1.000000e+00 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
G alpha (i) signalling events R-HSA-418594 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways