SRPK3

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

Log-Odds: S Sites / S Background

Sites with acceptor types representing >8% and count ≥10 are included

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Motif clusters with count ≥ 10 are shown

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substrate_uniprot	site	source	substrate_genes	site_seq
A0A2R8Y4L2	S95	Sugiyama	HNRNPA1L3 HNRNPA1P48	RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
O60841	S186	Sugiyama	EIF5B IF2 KIAA0741	EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05386	S104	Sugiyama	RPLP1 RRP1	tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387	S105	Sugiyama	RPLP2 D11S2243E RPP2	GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P06744	T109	Sugiyama	GPI	KINyTEGRAVLHVALRNRsNtPILVDGKDVMPEVNKVLDKM
P09651	S95	Sugiyama	HNRNPA1 HNRPA1	RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P10809	S70	Sugiyama	HSPD1 HSP60	AVAVTMGPKGRtVIIEQsWGsPKVTKDGVtVAKsIDLKDKY
P11142	S340	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	ALRDAKLDKsQIHDIVLVGGstRIPKIQKLLQDFFNGKELN
P31751	S474	Sugiyama	AKT2	DRyDsLGLLELDQRTHFPQFsysAsIRE_____________
P31751	S478	Sugiyama	AKT2	sLGLLELDQRTHFPQFsysAsIRE_________________
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39023	S265	Sugiyama	RPL3 OK/SW-cl.32	HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P46108	Y47	Sugiyama	CRK	LQGQRHGVFLVRDsstsPGDyVLSVSENSRVSHYIINSSGP
P46776	S68	Sugiyama	RPL27A	yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P49840	Y279	Sugiyama	GSK3A	LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P49841	Y216	Sugiyama	GSK3B	LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P51116	S601	Sugiyama	FXR2 FMR1L2	RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51116	S603	Sugiyama	FXR2 FMR1L2	QRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQsR
P51116	T598	Sugiyama	FXR2 FMR1L2	DESRPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRA
P60709	S52	Sugiyama	ACTB	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709	S60	Sugiyama	ACTB	HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P61978	S284	Sugiyama	HNRNPK HNRPK	MPPGRGGRPMPPSRRDyDDMsPRRGPPPPPPGRGGRGGsRA
P62263	S139	Sugiyama	RPS14 PRO2640	LARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL________
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62736	S54	Sugiyama	ACTA2 ACTSA ACTVS GIG46	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736	S62	Sugiyama	ACTA2 ACTSA ACTVS GIG46	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P63261	S52	Sugiyama	ACTG1 ACTG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261	S60	Sugiyama	ACTG1 ACTG	HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P63267	S53	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267	S61	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68032	S54	Sugiyama	ACTC1 ACTC	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032	S62	Sugiyama	ACTC1 ACTC	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68133	S54	Sugiyama	ACTA1 ACTA	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133	S62	Sugiyama	ACTA1 ACTA	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
Q07666	S20	Sugiyama	KHDRBS1 SAM68	_MQRRDDPAARMsRssGRsGsMDPsGAHPsVRQtPsRQPPL
Q13371	S25	Sugiyama	PDCL PHLOP1 PhLP1	DDKLLGEKLQyyysssEDEDsDHEDKDRGRCAPAsssVPAE
Q13442	S63	Sugiyama	PDAP1 HASPP28	GGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGVEGLIDI
Q15637	S82	Sugiyama	SF1 ZFM1 ZNF162	TRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFRTR
Q32P51	S95	Sugiyama	HNRNPA1L2 HNRNPA1L	TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q6PCE3	S175	Sugiyama	PGM2L1 BM32A	PFVPYAVQKLKAVAGVMItAsHNRKEDNGYKVYWETGAQIT
Q8IYB3	S402	Sugiyama	SRRM1 SRM160	PRKTRRLsPsAsPPRRRHRPsPPAtPPPKtRHsPtPQQsNR
Q96C19	S74	Sugiyama	EFHD2 SWS1	ELSAKLLRRADLNQGIGEPQsPsRRVFNPytEFKEFSRKQI
Q96JP5	S85	Sugiyama	ZFP91 ZNF757 FKSG11	AAAVSRRRKAEYPRRRRssPsARPPDVPGQQPQAAKsPsPV
Q96MU7	S308	Sugiyama	YTHDC1 KIAA1966 YT521	GSGTDGsDEKKKERKRARGIsPIVFDRsGssAsESYAGsEK
Q9BRS2	T509	Sugiyama	RIOK1 RIO1	QVEERtCsDsEDIGssECsDtDSEEQGDHARPKKHTTDPDI
Q9H7N4	S498	Sugiyama	SCAF1 SFRS19 SRA1	GGLDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKK
Q9H7N4	S500	Sugiyama	SCAF1 SFRS19 SRA1	LDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKKSR
Q9NPQ8	T441	Sugiyama	RIC8A	AARGLMAGGRPEGQysEDEDtDtDEyKEAKAsINPVTGRVE
Q9NWB6	S77	Sugiyama	ARGLU1	RsRstNTAVSRRERDRERAssPPDRIDIFGRTVSKRSSLDE
Q9NYV4	S249	Sugiyama	CDK12 CRK7 CRKRS KIAA0904	DSSKQDDsPsGAsYGQDyDLsPsRsHtssNYDsYKKsPGsT
Q9UPE1	Y116	Sugiyama	SRPK3 MSSK1 STK23	CWDIQRKRFVALKVVKSAGHyTETAVDEIKLLKCVRDSDPS
Q9UPR0	T584	Sugiyama	PLCL2 KIAA1092 PLCE2	KILIKAKKLsSNCSGVEGDVtDEDEGAEMSQRMGKENMEQP
Q9UQ35	S1102	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	EsPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFs
Q9UQ35	S1103	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35	S1648	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	APRALPRRSRSGSSSKGRGPsPEGssstEssPEHPPKSRTA
Q9UQ35	S2132	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9UQ35	S2692	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9UQ35	T328	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	APFsEPGttstQRPssPEtAtKQPssPYEDKDKDKKEKsAt
Q9Y383	S347	Sugiyama	LUC7L2 CGI-59 CGI-74	SRERSKRRSSKERFRDQDLAsCDRDRssRDRSPRDRDRKDK

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	2.111093e-09	8.675
Gene expression (Transcription)	R-HSA-74160	2.629978e-08	7.580
RNA Polymerase II Transcription	R-HSA-73857	3.411846e-08	7.467
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	1.502283e-07	6.823
mRNA 3'-end processing	R-HSA-72187	2.835290e-07	6.547
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	5.470028e-07	6.262
RNA Polymerase II Transcription Termination	R-HSA-73856	9.522464e-07	6.021
mRNA Splicing	R-HSA-72172	1.435452e-06	5.843
mRNA Splicing - Major Pathway	R-HSA-72163	1.618905e-06	5.791
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.077055e-05	4.968
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.624122e-05	4.789
Chromatin organization	R-HSA-4839726	1.450531e-05	4.838
Generic Transcription Pathway	R-HSA-212436	1.478970e-05	4.830
Cell Cycle	R-HSA-1640170	1.570649e-05	4.804
Cell Cycle, Mitotic	R-HSA-69278	1.590701e-05	4.798
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	3.616406e-05	4.442
Regulation of TP53 Activity	R-HSA-5633007	3.798692e-05	4.420
Chromatin modifying enzymes	R-HSA-3247509	4.207489e-05	4.376
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	4.490165e-05	4.348
NRAGE signals death through JNK	R-HSA-193648	8.371723e-05	4.077
Signaling by NTRKs	R-HSA-166520	1.663211e-04	3.779
PKMTs methylate histone lysines	R-HSA-3214841	2.038945e-04	3.691
Transcriptional Regulation by TP53	R-HSA-3700989	2.201037e-04	3.657
Regulation of MECP2 expression and activity	R-HSA-9022692	2.393757e-04	3.621
Mitotic Spindle Checkpoint	R-HSA-69618	3.293253e-04	3.482
Amplification of signal from the kinetochores	R-HSA-141424	3.513256e-04	3.454
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	3.513256e-04	3.454
Signaling by NTRK1 (TRKA)	R-HSA-187037	4.128692e-04	3.384
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	4.940804e-04	3.306
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	4.942533e-04	3.306
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	6.564396e-04	3.183
Mitotic Prometaphase	R-HSA-68877	6.868152e-04	3.163
Signal Transduction	R-HSA-162582	8.774064e-04	3.057
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	9.053925e-04	3.043
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	9.261811e-04	3.033
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	9.670927e-04	3.015
PI3K/AKT Signaling in Cancer	R-HSA-2219528	9.846661e-04	3.007
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	1.165750e-03	2.933
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.359368e-03	2.867
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	1.407461e-03	2.852
Metabolism of RNA	R-HSA-8953854	1.401394e-03	2.853
Protein-protein interactions at synapses	R-HSA-6794362	1.567429e-03	2.805
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	2.319778e-03	2.635
Transport of the SLBP independent Mature mRNA	R-HSA-159227	2.319778e-03	2.635
Vpr-mediated nuclear import of PICs	R-HSA-180910	2.210168e-03	2.656
Transcriptional regulation by RUNX1	R-HSA-8878171	2.117840e-03	2.674
Neurexins and neuroligins	R-HSA-6794361	2.062164e-03	2.686
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	2.173290e-03	2.663
Nuclear RNA decay	R-HSA-9930044	2.319778e-03	2.635
M Phase	R-HSA-68886	2.288626e-03	2.640
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	2.571895e-03	2.590
NGF-stimulated transcription	R-HSA-9031628	2.680327e-03	2.572
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	2.980604e-03	2.526
AKT phosphorylates targets in the cytosol	R-HSA-198323	2.888797e-03	2.539
HATs acetylate histones	R-HSA-3214847	2.778939e-03	2.556
Cell Cycle Checkpoints	R-HSA-69620	2.850494e-03	2.545
G alpha (12/13) signalling events	R-HSA-416482	3.002500e-03	2.523
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	3.150991e-03	2.502
Signaling by ALK	R-HSA-201556	3.206792e-03	2.494
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	3.430737e-03	2.465
Transcriptional Regulation by MECP2	R-HSA-8986944	3.688224e-03	2.433
Interactions of Vpr with host cellular proteins	R-HSA-176033	3.827328e-03	2.417
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	3.706449e-03	2.431
Signaling by ALK in cancer	R-HSA-9700206	3.706449e-03	2.431
Transcriptional regulation of granulopoiesis	R-HSA-9616222	3.891335e-03	2.410
RNA Polymerase II Pre-transcription Events	R-HSA-674695	3.899990e-03	2.409
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	4.221936e-03	2.374
Centrosome maturation	R-HSA-380287	4.421204e-03	2.354
Signaling by Hippo	R-HSA-2028269	4.537575e-03	2.343
RUNX2 regulates bone development	R-HSA-8941326	4.975948e-03	2.303
Axon guidance	R-HSA-422475	4.814902e-03	2.317
HIV Life Cycle	R-HSA-162587	4.976750e-03	2.303
Formation of RNA Pol II elongation complex	R-HSA-112382	4.985252e-03	2.302
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	4.999511e-03	2.301
RNA Polymerase II Transcription Elongation	R-HSA-75955	5.760676e-03	2.240
G2/M Transition	R-HSA-69275	6.068296e-03	2.217
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	6.515193e-03	2.186
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	6.490455e-03	2.188
Death Receptor Signaling	R-HSA-73887	6.751394e-03	2.171
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	7.187879e-03	2.143
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	6.972168e-03	2.157
Mitotic G2-G2/M phases	R-HSA-453274	7.010727e-03	2.154
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	7.004747e-03	2.155
Estrogen-dependent gene expression	R-HSA-9018519	7.547307e-03	2.122
Late Phase of HIV Life Cycle	R-HSA-162599	7.686251e-03	2.114
NS1 Mediated Effects on Host Pathways	R-HSA-168276	8.237718e-03	2.084
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	8.539136e-03	2.069
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	9.273858e-03	2.033
Type I hemidesmosome assembly	R-HSA-446107	9.564317e-03	2.019
Nuclear import of Rev protein	R-HSA-180746	9.170942e-03	2.038
Interactions of Rev with host cellular proteins	R-HSA-177243	9.634077e-03	2.016
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.010802e-02	1.995
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	1.154245e-02	1.938
Pervasive developmental disorders	R-HSA-9005895	1.144483e-02	1.941
Disorders of Nervous System Development	R-HSA-9697154	1.144483e-02	1.941
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	1.144483e-02	1.941
ATP-dependent chromatin remodelers	R-HSA-9932444	1.097897e-02	1.959
SWI/SNF chromatin remodelers	R-HSA-9932451	1.097897e-02	1.959
Mitotic Anaphase	R-HSA-68882	1.177033e-02	1.929
Nervous system development	R-HSA-9675108	1.179272e-02	1.928
Disorders of Developmental Biology	R-HSA-9675151	1.193883e-02	1.923
Processing of Intronless Pre-mRNAs	R-HSA-77595	1.193883e-02	1.923
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.203060e-02	1.920
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.203060e-02	1.920
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	1.323495e-02	1.878
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	1.323495e-02	1.878
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.251983e-02	1.902
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.347403e-02	1.871
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.347403e-02	1.871
AURKA Activation by TPX2	R-HSA-8854518	1.383816e-02	1.859
Apoptotic cleavage of cellular proteins	R-HSA-111465	1.421677e-02	1.847
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	1.447280e-02	1.839
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.474702e-02	1.831
MTOR signalling	R-HSA-165159	1.494053e-02	1.826
Epigenetic regulation of gene expression	R-HSA-212165	1.510686e-02	1.821
IPs transport between nucleus and cytosol	R-HSA-1855170	1.668682e-02	1.778
Heme signaling	R-HSA-9707616	1.797994e-02	1.745
FOXO-mediated transcription of cell death genes	R-HSA-9614657	1.862144e-02	1.730
Polo-like kinase mediated events	R-HSA-156711	1.862144e-02	1.730
p75 NTR receptor-mediated signalling	R-HSA-193704	1.914211e-02	1.718
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	1.946070e-02	1.711
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	1.967825e-02	1.706
Regulation of TP53 Expression and Degradation	R-HSA-6806003	1.967825e-02	1.706
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	2.007782e-02	1.697
Loss of Nlp from mitotic centrosomes	R-HSA-380259	2.007782e-02	1.697
Signaling by NOTCH1	R-HSA-1980143	2.020307e-02	1.695
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	2.073046e-02	1.683
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	2.274115e-02	1.643
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	2.121597e-02	1.673
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	2.309764e-02	1.636
PIP3 activates AKT signaling	R-HSA-1257604	2.379987e-02	1.623
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	2.418879e-02	1.616
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	2.481687e-02	1.605
Apoptotic execution phase	R-HSA-75153	2.513923e-02	1.600
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	2.573244e-02	1.590
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	2.599700e-02	1.585
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	2.756735e-02	1.560
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	2.960551e-02	1.529
MECP2 regulates transcription factors	R-HSA-9022707	2.960551e-02	1.529
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	2.960551e-02	1.529
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	2.996261e-02	1.523
Trafficking of AMPA receptors	R-HSA-399719	2.989991e-02	1.524
RET signaling	R-HSA-8853659	2.979601e-02	1.526
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	3.181881e-02	1.497
Regulation of gap junction activity	R-HSA-191650	3.295850e-02	1.482
PLCG1 events in ERBB2 signaling	R-HSA-1251932	3.295850e-02	1.482
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	3.295850e-02	1.482
TNFR1-induced proapoptotic signaling	R-HSA-5357786	3.297865e-02	1.482
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	3.344655e-02	1.476
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	3.427160e-02	1.465
ISG15 antiviral mechanism	R-HSA-1169408	3.446065e-02	1.463
Separation of Sister Chromatids	R-HSA-2467813	3.550670e-02	1.450
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	3.550891e-02	1.450
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	3.937523e-02	1.405
Cardiogenesis	R-HSA-9733709	3.949938e-02	1.403
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	3.949938e-02	1.403
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	3.575155e-02	1.447
ESR-mediated signaling	R-HSA-8939211	3.759213e-02	1.425
Signaling by LTK	R-HSA-9842663	3.937523e-02	1.405
Intracellular signaling by second messengers	R-HSA-9006925	3.570117e-02	1.447
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	3.949938e-02	1.403
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	3.970138e-02	1.401
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	3.970138e-02	1.401
Signaling by MRAS-complex mutants	R-HSA-9660537	3.970138e-02	1.401
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	3.970138e-02	1.401
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	3.970138e-02	1.401
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	3.980744e-02	1.400
Regulation of CDH1 Gene Transcription	R-HSA-9764560	4.029230e-02	1.395
Nuclear Envelope Breakdown	R-HSA-2980766	4.159668e-02	1.381
Signaling by ROBO receptors	R-HSA-376176	4.230720e-02	1.374
Defective Base Excision Repair Associated with OGG1	R-HSA-9656249	4.748130e-02	1.323
Transport of glycerol from adipocytes to the liver by Aquaporins	R-HSA-432030	4.748130e-02	1.323
SMAC (DIABLO) binds to IAPs	R-HSA-111463	4.817932e-02	1.317
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	4.817932e-02	1.317
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	4.817932e-02	1.317
IRS activation	R-HSA-74713	4.817932e-02	1.317
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	4.817932e-02	1.317
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	4.351352e-02	1.361
Transcriptional regulation by small RNAs	R-HSA-5578749	4.808471e-02	1.318
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	4.582013e-02	1.339
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	4.625633e-02	1.335
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	4.869631e-02	1.313
Frs2-mediated activation	R-HSA-170968	4.869631e-02	1.313
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	4.869631e-02	1.313
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	4.890652e-02	1.311
HIV Transcription Elongation	R-HSA-167169	4.890652e-02	1.311
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	4.890652e-02	1.311
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	5.046159e-02	1.297
snRNP Assembly	R-HSA-191859	5.046159e-02	1.297
Metabolism of non-coding RNA	R-HSA-194441	5.046159e-02	1.297
RAF activation	R-HSA-5673000	5.099819e-02	1.292
GP1b-IX-V activation signalling	R-HSA-430116	5.152384e-02	1.288
Inactivation of CDC42 and RAC1	R-HSA-428543	5.152384e-02	1.288
Regulation of CDH11 gene transcription	R-HSA-9762293	5.152384e-02	1.288
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	5.921008e-02	1.228
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	5.921008e-02	1.228
Signaling by ERBB2 ECD mutants	R-HSA-9665348	5.241272e-02	1.281
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	5.986925e-02	1.223
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	5.277275e-02	1.278
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	5.986925e-02	1.223
Signaling by ERBB2	R-HSA-1227986	5.534715e-02	1.257
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	5.579243e-02	1.253
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	5.241272e-02	1.281
Kinesins	R-HSA-983189	5.534715e-02	1.257
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	5.921008e-02	1.228
Interleukin-37 signaling	R-HSA-9008059	5.986925e-02	1.223
Cell junction organization	R-HSA-446728	6.044940e-02	1.219
Transcription of the HIV genome	R-HSA-167172	6.129713e-02	1.213
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	6.342822e-02	1.198
Regulation of TP53 Degradation	R-HSA-6804757	6.449938e-02	1.190
Signal attenuation	R-HSA-74749	6.505704e-02	1.187
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	6.505704e-02	1.187
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	6.624172e-02	1.179
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	6.624172e-02	1.179
Negative feedback regulation of MAPK pathway	R-HSA-5674499	6.624172e-02	1.179
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	6.624172e-02	1.179
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	7.838973e-02	1.106
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	7.838973e-02	1.106
Regulation of cortical dendrite branching	R-HSA-8985801	7.838973e-02	1.106
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	7.838973e-02	1.106
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	7.838973e-02	1.106
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	7.838973e-02	1.106
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	7.838973e-02	1.106
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	7.838973e-02	1.106
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	7.838973e-02	1.106
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	7.838973e-02	1.106
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	7.838973e-02	1.106
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	7.838973e-02	1.106
Regulation of localization of FOXO transcription factors	R-HSA-9614399	8.025338e-02	1.096
Oncogenic MAPK signaling	R-HSA-6802957	7.695548e-02	1.114
Regulation of endogenous retroelements	R-HSA-9842860	6.925789e-02	1.160
Regulation of TP53 Expression	R-HSA-6804754	7.838973e-02	1.106
Sema4D in semaphorin signaling	R-HSA-400685	7.040600e-02	1.152
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	7.185704e-02	1.144
Semaphorin interactions	R-HSA-373755	7.189156e-02	1.143
TRP channels	R-HSA-3295583	8.005707e-02	1.097
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	7.764419e-02	1.110
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	7.116997e-02	1.148
LGI-ADAM interactions	R-HSA-5682910	8.025338e-02	1.096
Differentiation of T cells	R-HSA-9945266	8.379496e-02	1.077
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	8.379496e-02	1.077
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	8.379496e-02	1.077
Prolonged ERK activation events	R-HSA-169893	8.379496e-02	1.077
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	8.379496e-02	1.077
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	8.533564e-02	1.069
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	8.533564e-02	1.069
Cellular Senescence	R-HSA-2559583	8.663175e-02	1.062
Regulation of NFE2L2 gene expression	R-HSA-9818749	8.692215e-02	1.061
Transcriptional Regulation by E2F6	R-HSA-8953750	8.863317e-02	1.052
Regulation of CDH1 Expression and Function	R-HSA-9764265	8.916400e-02	1.050
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	8.916400e-02	1.050
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	8.941305e-02	1.049
Activation of RAC1	R-HSA-428540	9.703817e-02	1.013
Signaling by AXIN mutants	R-HSA-4839735	9.703817e-02	1.013
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	9.703817e-02	1.013
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	9.781895e-02	1.010
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	1.077535e-01	0.968
Interaction between L1 and Ankyrins	R-HSA-445095	9.043518e-02	1.044
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	9.043518e-02	1.044
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	9.043518e-02	1.044
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	1.015318e-01	0.993
HIV elongation arrest and recovery	R-HSA-167287	1.015318e-01	0.993
Formation of the Early Elongation Complex	R-HSA-113418	1.015318e-01	0.993
Pausing and recovery of HIV elongation	R-HSA-167290	1.015318e-01	0.993
mRNA Splicing - Minor Pathway	R-HSA-72165	9.907637e-02	1.004
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	9.924570e-02	1.003
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	1.019844e-01	0.991
DNA Double Strand Break Response	R-HSA-5693606	9.850539e-02	1.007
CD28 dependent PI3K/Akt signaling	R-HSA-389357	9.043518e-02	1.044
Regulation of TNFR1 signaling	R-HSA-5357905	9.907637e-02	1.004
Mitotic Telophase/Cytokinesis	R-HSA-68884	9.703817e-02	1.013
Signaling by NTRK3 (TRKC)	R-HSA-9034015	9.490946e-02	1.023
G2/M DNA damage checkpoint	R-HSA-69473	9.740616e-02	1.011
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	9.924570e-02	1.003
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	9.924570e-02	1.003
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	9.924570e-02	1.003
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	9.924570e-02	1.003
DNA Damage Recognition in GG-NER	R-HSA-5696394	9.504097e-02	1.022
Cell-Cell communication	R-HSA-1500931	1.038639e-01	0.984
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	9.054782e-02	1.043
Signaling by NTRK2 (TRKB)	R-HSA-9006115	9.043518e-02	1.044
Signaling by NOTCH1 in Cancer	R-HSA-2644603	9.924570e-02	1.003
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	1.077535e-01	0.968
Glycolysis	R-HSA-70171	9.674323e-02	1.014
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	9.907637e-02	1.004
Defective OGG1 Localization	R-HSA-9657050	1.087010e-01	0.964
Deletions in the AXIN1 gene destabilize the destruction complex	R-HSA-5467345	1.087010e-01	0.964
Defective OGG1 Substrate Binding	R-HSA-9656255	1.087010e-01	0.964
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.087010e-01	0.964
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	1.087010e-01	0.964
Cohesin Loading onto Chromatin	R-HSA-2470946	1.099498e-01	0.959
RUNX3 regulates WNT signaling	R-HSA-8951430	1.099498e-01	0.959
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	1.099498e-01	0.959
S Phase	R-HSA-69242	1.101615e-01	0.958
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	1.129439e-01	0.947
Signaling by Erythropoietin	R-HSA-9006335	1.133334e-01	0.946
Regulation of CDH11 Expression and Function	R-HSA-9759475	1.133334e-01	0.946
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.143373e-01	0.942
RUNX3 regulates NOTCH signaling	R-HSA-8941856	1.153143e-01	0.938
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	1.153143e-01	0.938
Signalling to ERKs	R-HSA-187687	1.162469e-01	0.935
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	1.169766e-01	0.932
Negative regulation of the PI3K/AKT network	R-HSA-199418	1.205657e-01	0.919
Adherens junctions interactions	R-HSA-418990	1.215170e-01	0.915
L1CAM interactions	R-HSA-373760	1.216226e-01	0.915
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	1.524654e-01	0.817
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	1.524654e-01	0.817
Regulation of HMOX1 expression and activity	R-HSA-9707587	1.524654e-01	0.817
TNFR1-mediated ceramide production	R-HSA-5626978	1.524654e-01	0.817
HCN channels	R-HSA-1296061	1.524654e-01	0.817
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	1.524654e-01	0.817
AKT-mediated inactivation of FOXO1A	R-HSA-211163	1.524654e-01	0.817
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	1.524654e-01	0.817
Inhibition of TSC complex formation by PKB	R-HSA-165181	1.524654e-01	0.817
FBXW7 Mutants and NOTCH1 in Cancer	R-HSA-2644605	1.524654e-01	0.817
GRB7 events in ERBB2 signaling	R-HSA-1306955	1.524654e-01	0.817
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	R-HSA-2644607	1.524654e-01	0.817
Formation of annular gap junctions	R-HSA-196025	1.350263e-01	0.870
MET receptor recycling	R-HSA-8875656	1.350263e-01	0.870
Ephrin signaling	R-HSA-3928664	1.291157e-01	0.889
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	1.462704e-01	0.835
Diseases of mitotic cell cycle	R-HSA-9675126	1.527612e-01	0.816
Nonsense-Mediated Decay (NMD)	R-HSA-927802	1.319744e-01	0.880
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	1.319744e-01	0.880
Transcriptional regulation by RUNX2	R-HSA-8878166	1.415197e-01	0.849
FOXO-mediated transcription	R-HSA-9614085	1.401457e-01	0.853
Processing of DNA double-strand break ends	R-HSA-5693607	1.531666e-01	0.815
Nucleotide Excision Repair	R-HSA-5696398	1.360046e-01	0.866
G0 and Early G1	R-HSA-1538133	1.527612e-01	0.816
TGFBR3 expression	R-HSA-9839394	1.512100e-01	0.820
Hedgehog 'on' state	R-HSA-5632684	1.303867e-01	0.885
DNA Double-Strand Break Repair	R-HSA-5693532	1.381685e-01	0.860
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	1.391651e-01	0.856
TNF signaling	R-HSA-75893	1.259743e-01	0.900
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	1.289016e-01	0.890
Activation of HOX genes during differentiation	R-HSA-5619507	1.289016e-01	0.890
Homology Directed Repair	R-HSA-5693538	1.346906e-01	0.871
Circadian clock	R-HSA-9909396	1.392197e-01	0.856
Regulation of TP53 Activity through Methylation	R-HSA-6804760	1.291157e-01	0.889
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	1.455831e-01	0.837
Mitotic Prophase	R-HSA-68875	1.485434e-01	0.828
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	1.524654e-01	0.817
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	1.349669e-01	0.870
TBC/RABGAPs	R-HSA-8854214	1.391678e-01	0.856
HIV Infection	R-HSA-162906	1.268713e-01	0.897
Inositol phosphate metabolism	R-HSA-1483249	1.319744e-01	0.880
Interleukin-7 signaling	R-HSA-1266695	1.512100e-01	0.820
Defective OGG1 Substrate Processing	R-HSA-9656256	2.055917e-01	0.687
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.055917e-01	0.687
Diseases of Telomere Maintenance	R-HSA-9673013	2.055917e-01	0.687
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.055917e-01	0.687
Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)	R-HSA-9036092	2.055917e-01	0.687
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	2.055917e-01	0.687
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	2.055917e-01	0.687
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.055917e-01	0.687
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.055917e-01	0.687
Nef mediated downregulation of CD28 cell surface expression	R-HSA-164939	2.919548e-01	0.535
Breakdown of the nuclear lamina	R-HSA-352238	2.919548e-01	0.535
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.919548e-01	0.535
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	2.919548e-01	0.535
Defective VWF binding to collagen type I	R-HSA-9845622	2.919548e-01	0.535
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	2.919548e-01	0.535
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.919548e-01	0.535
Defective APRT disrupts adenine salvage	R-HSA-9734195	2.919548e-01	0.535
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	R-HSA-5083628	2.919548e-01	0.535
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	2.919548e-01	0.535
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	1.931718e-01	0.714
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	1.931718e-01	0.714
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	1.618408e-01	0.791
Lipophagy	R-HSA-9613354	1.618408e-01	0.791
Gap junction degradation	R-HSA-190873	1.618408e-01	0.791
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	2.350466e-01	0.629
Signalling to p38 via RIT and RIN	R-HSA-187706	2.350466e-01	0.629
Phosphorylation of Emi1	R-HSA-176417	2.350466e-01	0.629
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	R-HSA-5083629	3.689335e-01	0.433
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	3.689335e-01	0.433
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.689335e-01	0.433
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	R-HSA-5083633	3.689335e-01	0.433
Enhanced cleavage of VWF variant by ADAMTS13	R-HSA-9845619	3.689335e-01	0.433
Potassium transport channels	R-HSA-1296067	3.689335e-01	0.433
Defective VWF cleavage by ADAMTS13 variant	R-HSA-9845621	3.689335e-01	0.433
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	1.900818e-01	0.721
MET activates RAP1 and RAC1	R-HSA-8875555	1.900818e-01	0.721
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.900818e-01	0.721
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	1.900818e-01	0.721
Retrograde neurotrophin signalling	R-HSA-177504	1.558676e-01	0.807
PTK6 promotes HIF1A stabilization	R-HSA-8857538	2.773553e-01	0.557
Autointegration results in viral DNA circles	R-HSA-177539	2.773553e-01	0.557
ChREBP activates metabolic gene expression	R-HSA-163765	2.194453e-01	0.659
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	2.194453e-01	0.659
Signaling by APC mutants	R-HSA-4839744	2.194453e-01	0.659
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	2.194453e-01	0.659
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	2.194453e-01	0.659
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	2.194453e-01	0.659
Presynaptic depolarization and calcium channel opening	R-HSA-112308	2.194453e-01	0.659
Erythropoietin activates RAS	R-HSA-9027284	1.778786e-01	0.750
Translesion synthesis by REV1	R-HSA-110312	1.778786e-01	0.750
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.643362e-01	0.784
Translesion synthesis by POLI	R-HSA-5656121	2.008563e-01	0.697
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	2.496417e-01	0.603
Signaling by GSK3beta mutants	R-HSA-5339716	2.496417e-01	0.603
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	3.195091e-01	0.496
PTK6 Expression	R-HSA-8849473	3.195091e-01	0.496
SOS-mediated signalling	R-HSA-112412	3.195091e-01	0.496
Activated NTRK3 signals through PLCG1	R-HSA-9034793	4.375472e-01	0.359
PLC-gamma1 signalling	R-HSA-167021	4.375472e-01	0.359
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	4.375472e-01	0.359
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	4.375472e-01	0.359
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	4.375472e-01	0.359
Defective GCLC causes HAGGSD	R-HSA-5578999	4.375472e-01	0.359
Invadopodia formation	R-HSA-8941237	4.375472e-01	0.359
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	4.375472e-01	0.359
MET activates PTPN11	R-HSA-8865999	4.375472e-01	0.359
Defective GSS causes GSS deficiency	R-HSA-5579006	4.375472e-01	0.359
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	4.375472e-01	0.359
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	2.246542e-01	0.648
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	2.246542e-01	0.648
Translesion synthesis by POLK	R-HSA-5655862	2.246542e-01	0.648
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	2.246542e-01	0.648
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	1.672039e-01	0.777
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	2.803997e-01	0.552
RUNX3 regulates p14-ARF	R-HSA-8951936	2.803997e-01	0.552
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	2.803997e-01	0.552
SHC-related events triggered by IGF1R	R-HSA-2428933	2.803997e-01	0.552
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	2.803997e-01	0.552
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	2.803997e-01	0.552
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	2.803997e-01	0.552
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	2.803997e-01	0.552
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	2.803997e-01	0.552
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	2.028839e-01	0.693
ROBO receptors bind AKAP5	R-HSA-9010642	3.610421e-01	0.442
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	3.610421e-01	0.442
EGFR interacts with phospholipase C-gamma	R-HSA-212718	3.610421e-01	0.442
Regulation of NPAS4 mRNA translation	R-HSA-9768778	3.610421e-01	0.442
Notch-HLH transcription pathway	R-HSA-350054	2.231964e-01	0.651
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	3.114691e-01	0.507
Signaling by ERBB2 KD Mutants	R-HSA-9664565	2.190173e-01	0.660
Late endosomal microautophagy	R-HSA-9615710	2.190173e-01	0.660
Impaired BRCA2 binding to RAD51	R-HSA-9709570	2.190173e-01	0.660
Signaling by ERBB2 in Cancer	R-HSA-1227990	2.373773e-01	0.625
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	2.373773e-01	0.625
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	2.373773e-01	0.625
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	2.654568e-01	0.576
Deadenylation of mRNA	R-HSA-429947	2.654568e-01	0.576
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	2.995192e-01	0.524
Impaired BRCA2 binding to PALB2	R-HSA-9709603	2.995192e-01	0.524
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	3.426227e-01	0.465
ALK mutants bind TKIs	R-HSA-9700645	4.015911e-01	0.396
MTF1 activates gene expression	R-HSA-5660489	4.987042e-01	0.302
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	4.987042e-01	0.302
Activated NTRK2 signals through PLCG1	R-HSA-9026527	4.987042e-01	0.302
Signaling by MAP2K mutants	R-HSA-9652169	4.987042e-01	0.302
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	4.987042e-01	0.302
Translation initiation complex formation	R-HSA-72649	1.830162e-01	0.738
Co-inhibition by CTLA4	R-HSA-389513	3.251669e-01	0.488
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	3.251669e-01	0.488
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	3.251669e-01	0.488
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	3.251669e-01	0.488
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	3.251669e-01	0.488
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	2.469185e-01	0.607
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	2.753705e-01	0.560
Beta-catenin phosphorylation cascade	R-HSA-196299	3.736568e-01	0.428
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	1.831908e-01	0.737
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	3.509440e-01	0.455
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	4.408794e-01	0.356
Nuclear Receptor transcription pathway	R-HSA-383280	1.981826e-01	0.703
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	2.253296e-01	0.647
Phosphorylation of the APC/C	R-HSA-176412	4.043912e-01	0.393
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	2.994965e-01	0.524
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	2.994965e-01	0.524
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	2.994965e-01	0.524
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	2.857649e-01	0.544
Signaling downstream of RAS mutants	R-HSA-9649948	2.857649e-01	0.544
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	2.857649e-01	0.544
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	3.767315e-01	0.424
HDACs deacetylate histones	R-HSA-3214815	3.037734e-01	0.517
MAP2K and MAPK activation	R-HSA-5674135	3.357632e-01	0.474
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	3.357632e-01	0.474
Signaling by RAF1 mutants	R-HSA-9656223	3.357632e-01	0.474
HIV Transcription Initiation	R-HSA-167161	3.357632e-01	0.474
RNA Polymerase II Transcription Initiation	R-HSA-75953	3.357632e-01	0.474
FGFR2 alternative splicing	R-HSA-6803529	4.024191e-01	0.395
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	4.787019e-01	0.320
Activated NTRK3 signals through RAS	R-HSA-9034864	4.787019e-01	0.320
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	5.532147e-01	0.257
Activation of AMPA receptors	R-HSA-399710	5.532147e-01	0.257
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	5.532147e-01	0.257
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	5.532147e-01	0.257
Ribosomal scanning and start codon recognition	R-HSA-72702	3.193567e-01	0.496
Activation of the pre-replicative complex	R-HSA-68962	3.990267e-01	0.399
SHC1 events in ERBB2 signaling	R-HSA-1250196	3.990267e-01	0.399
RNA Polymerase II Promoter Escape	R-HSA-73776	3.725773e-01	0.429
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	3.035210e-01	0.518
PI3K events in ERBB2 signaling	R-HSA-1963642	4.643538e-01	0.333
Cellular response to heat stress	R-HSA-3371556	2.973764e-01	0.527
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	5.149130e-01	0.288
Activated NTRK2 signals through RAS	R-HSA-9026519	5.149130e-01	0.288
ERKs are inactivated	R-HSA-202670	5.149130e-01	0.288
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	3.248260e-01	0.488
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	4.095888e-01	0.388
GAB1 signalosome	R-HSA-180292	4.933323e-01	0.307
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	4.933323e-01	0.307
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	4.779179e-01	0.321
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	3.807828e-01	0.419
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	4.093682e-01	0.388
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	4.555511e-01	0.341
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	5.494159e-01	0.260
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	5.494159e-01	0.260
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	6.018007e-01	0.221
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	6.018007e-01	0.221
Nef Mediated CD8 Down-regulation	R-HSA-182218	6.018007e-01	0.221
PDE3B signalling	R-HSA-165160	6.018007e-01	0.221
PKB-mediated events	R-HSA-109703	6.018007e-01	0.221
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	6.018007e-01	0.221
PTK6 Regulates Cell Cycle	R-HSA-8849470	6.018007e-01	0.221
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	6.018007e-01	0.221
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	6.018007e-01	0.221
Signaling by MAPK mutants	R-HSA-9652817	6.018007e-01	0.221
Dual Incision in GG-NER	R-HSA-5696400	5.088732e-01	0.293
Dual incision in TC-NER	R-HSA-6782135	4.893698e-01	0.310
RNA Polymerase I Promoter Opening	R-HSA-73728	5.261437e-01	0.279
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	4.849734e-01	0.314
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	4.812350e-01	0.318
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	5.141704e-01	0.289
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	5.488068e-01	0.261
Activation of AMPK downstream of NMDARs	R-HSA-9619483	5.494313e-01	0.260
Phase 0 - rapid depolarisation	R-HSA-5576892	5.494313e-01	0.260
Formation of axial mesoderm	R-HSA-9796292	5.821540e-01	0.235
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	5.821540e-01	0.235
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	5.821540e-01	0.235
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	5.154606e-01	0.288
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	5.505751e-01	0.259
PRC2 methylates histones and DNA	R-HSA-212300	5.505751e-01	0.259
Meiotic synapsis	R-HSA-1221632	5.534594e-01	0.257
mRNA Capping	R-HSA-72086	5.721028e-01	0.243
DNA methylation	R-HSA-5334118	5.721028e-01	0.243
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	5.721028e-01	0.243
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	5.721028e-01	0.243
Formation of a pool of free 40S subunits	R-HSA-72689	5.612506e-01	0.251
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	6.005371e-01	0.221
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	6.005371e-01	0.221
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	6.005371e-01	0.221
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	6.131031e-01	0.212
Signaling by EGFR in Cancer	R-HSA-1643713	5.022874e-01	0.299
RNA Polymerase III Transcription	R-HSA-74158	5.505751e-01	0.259
Transcriptional regulation by RUNX3	R-HSA-8878159	4.729966e-01	0.325
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	3.509440e-01	0.455
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	3.509440e-01	0.455
Signaling by EGFRvIII in Cancer	R-HSA-5637812	2.491260e-01	0.604
Constitutive Signaling by EGFRvIII	R-HSA-5637810	2.491260e-01	0.604
HDMs demethylate histones	R-HSA-3214842	2.872262e-01	0.542
Signaling by EGFR	R-HSA-177929	2.079489e-01	0.682
Adipogenesis	R-HSA-9843745	4.278078e-01	0.369
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	4.933323e-01	0.307
RNA Polymerase III Transcription Initiation	R-HSA-76046	5.941188e-01	0.226
Integrin signaling	R-HSA-354192	1.671551e-01	0.777
Downstream signaling of activated FGFR3	R-HSA-5654708	3.765433e-01	0.424
Downstream signaling of activated FGFR4	R-HSA-5654716	3.990267e-01	0.399
Downstream signaling of activated FGFR2	R-HSA-5654696	5.299307e-01	0.276
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	4.598653e-01	0.337
Transcriptional regulation of testis differentiation	R-HSA-9690406	2.246542e-01	0.648
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	5.751649e-01	0.240
Termination of translesion DNA synthesis	R-HSA-5656169	5.721028e-01	0.243
Synaptic adhesion-like molecules	R-HSA-8849932	2.741275e-01	0.562
Developmental Lineages of the Mammary Gland	R-HSA-9924644	2.169430e-01	0.664
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	3.346192e-01	0.475
Downstream signaling of activated FGFR1	R-HSA-5654687	5.299307e-01	0.276
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	2.654568e-01	0.576
Neurodegenerative Diseases	R-HSA-8863678	2.654568e-01	0.576
Repression of WNT target genes	R-HSA-4641265	2.803997e-01	0.552
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	5.261437e-01	0.279
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	5.565814e-01	0.254
Platelet Aggregation (Plug Formation)	R-HSA-76009	2.695232e-01	0.569
Co-stimulation by CD28	R-HSA-389356	2.015006e-01	0.696
Chaperone Mediated Autophagy	R-HSA-9613829	4.933323e-01	0.307
Insulin receptor signalling cascade	R-HSA-74751	5.864731e-01	0.232
Cytochrome c-mediated apoptotic response	R-HSA-111461	2.496417e-01	0.603
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	1.671551e-01	0.777
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	4.015911e-01	0.396
Regulation of the apoptosome activity	R-HSA-9627069	4.408794e-01	0.356
Polymerase switching on the C-strand of the telomere	R-HSA-174411	4.779179e-01	0.321
IGF1R signaling cascade	R-HSA-2428924	3.191230e-01	0.496
Germ layer formation at gastrulation	R-HSA-9754189	5.215090e-01	0.283
MHC class II antigen presentation	R-HSA-2132295	6.110061e-01	0.214
Formation of lateral plate mesoderm	R-HSA-9758920	2.350466e-01	0.629
Activated NTRK3 signals through PI3K	R-HSA-9603381	3.195091e-01	0.496
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	3.610421e-01	0.442
Formation of apoptosome	R-HSA-111458	4.408794e-01	0.356
PI3K/AKT activation	R-HSA-198203	4.408794e-01	0.356
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	4.787019e-01	0.320
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	2.666068e-01	0.574
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	6.018007e-01	0.221
Peptide chain elongation	R-HSA-156902	5.597096e-01	0.252
CRMPs in Sema3A signaling	R-HSA-399956	6.131031e-01	0.212
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	3.316042e-01	0.479
Downregulation of ERBB2 signaling	R-HSA-8863795	2.373773e-01	0.625
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	5.088732e-01	0.293
Signaling by RAS mutants	R-HSA-6802949	2.857649e-01	0.544
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	3.346192e-01	0.475
Formation of definitive endoderm	R-HSA-9823730	1.643362e-01	0.784
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	5.261437e-01	0.279
NTRK3 as a dependence receptor	R-HSA-9603505	2.919548e-01	0.535
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	1.618408e-01	0.791
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	1.618408e-01	0.791
Polymerase switching	R-HSA-69091	2.803997e-01	0.552
Leading Strand Synthesis	R-HSA-69109	2.803997e-01	0.552
Role of second messengers in netrin-1 signaling	R-HSA-418890	2.803997e-01	0.552
mTORC1-mediated signalling	R-HSA-166208	2.231964e-01	0.651
Passive transport by Aquaporins	R-HSA-432047	4.346686e-01	0.362
Cyclin E associated events during G1/S transition	R-HSA-69202	2.908269e-01	0.536
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	4.279058e-01	0.369
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	4.554172e-01	0.342
Translesion Synthesis by POLH	R-HSA-110320	5.215090e-01	0.283
Ligand-receptor interactions	R-HSA-5632681	6.018007e-01	0.221
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	4.526724e-01	0.344
RNA Polymerase I Transcription Termination	R-HSA-73863	5.261437e-01	0.279
MET promotes cell motility	R-HSA-8875878	5.904822e-01	0.229
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	2.881596e-01	0.540
Clathrin-mediated endocytosis	R-HSA-8856828	3.118076e-01	0.506
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	3.339345e-01	0.476
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	2.995192e-01	0.524
TRAF3-dependent IRF activation pathway	R-HSA-918233	4.346686e-01	0.362
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	5.862564e-01	0.232
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	4.151489e-01	0.382
Integration of provirus	R-HSA-162592	2.496417e-01	0.603
Recycling pathway of L1	R-HSA-437239	3.022467e-01	0.520
Apoptotic factor-mediated response	R-HSA-111471	4.933323e-01	0.307
NoRC negatively regulates rRNA expression	R-HSA-427413	4.245649e-01	0.372
Eukaryotic Translation Initiation	R-HSA-72613	5.305736e-01	0.275
G1 Phase	R-HSA-69236	3.910795e-01	0.408
Cyclin D associated events in G1	R-HSA-69231	3.910795e-01	0.408
Deadenylation-dependent mRNA decay	R-HSA-429914	3.669334e-01	0.435
Resolution of D-Loop Structures	R-HSA-5693537	4.874445e-01	0.312
TCF dependent signaling in response to WNT	R-HSA-201681	1.850147e-01	0.733
Meiosis	R-HSA-1500620	5.043034e-01	0.297
Signal amplification	R-HSA-392518	5.088732e-01	0.293
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.977206e-01	0.704
Signaling by FGFR2	R-HSA-5654738	4.328020e-01	0.364
Post-transcriptional silencing by small RNAs	R-HSA-426496	1.931718e-01	0.714
Apoptosis induced DNA fragmentation	R-HSA-140342	1.900818e-01	0.721
DCC mediated attractive signaling	R-HSA-418885	1.778786e-01	0.750
Activation of SMO	R-HSA-5635838	2.008563e-01	0.697
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	2.496417e-01	0.603
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	2.440838e-01	0.612
Signaling by FGFR4 in disease	R-HSA-5655291	3.426227e-01	0.465
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	4.015911e-01	0.396
Calcineurin activates NFAT	R-HSA-2025928	4.015911e-01	0.396
Formation of the posterior neural plate	R-HSA-9832991	4.787019e-01	0.320
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	5.532147e-01	0.257
PTK6 Down-Regulation	R-HSA-8849472	5.532147e-01	0.257
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	4.656911e-01	0.332
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	4.092102e-01	0.388
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	6.018007e-01	0.221
Cap-dependent Translation Initiation	R-HSA-72737	5.305736e-01	0.275
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	5.581512e-01	0.253
Signaling by FGFR4	R-HSA-5654743	3.725773e-01	0.429
Signaling by FGFR1 in disease	R-HSA-5655302	4.948261e-01	0.306
Maternal to zygotic transition (MZT)	R-HSA-9816359	6.110061e-01	0.214
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	3.190952e-01	0.496
Signaling by NOTCH3	R-HSA-9012852	1.953083e-01	0.709
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	5.022874e-01	0.299
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	3.146502e-01	0.502
Ovarian tumor domain proteases	R-HSA-5689896	3.951347e-01	0.403
RNA Polymerase I Transcription	R-HSA-73864	5.293176e-01	0.276
Signaling by Nuclear Receptors	R-HSA-9006931	2.945688e-01	0.531
RMTs methylate histone arginines	R-HSA-3214858	2.535573e-01	0.596
Signaling by FGFR3	R-HSA-5654741	4.095888e-01	0.388
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	2.496417e-01	0.603
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	2.803997e-01	0.552
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	3.114691e-01	0.507
Signaling by WNT	R-HSA-195721	4.295323e-01	0.367
Mitotic G1 phase and G1/S transition	R-HSA-453279	3.412653e-01	0.467
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	4.408794e-01	0.356
DNA Repair	R-HSA-73894	2.290619e-01	0.640
Regulation of CDH19 Expression and Function	R-HSA-9764302	2.350466e-01	0.629
Inhibition of nitric oxide production	R-HSA-9636249	4.375472e-01	0.359
Downregulation of ERBB4 signaling	R-HSA-1253288	3.610421e-01	0.442
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	4.987042e-01	0.302
Elevation of cytosolic Ca2+ levels	R-HSA-139853	4.643538e-01	0.333
VEGFR2 mediated vascular permeability	R-HSA-5218920	4.752287e-01	0.323
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	5.821540e-01	0.235
Autophagy	R-HSA-9612973	4.429145e-01	0.354
Apoptosis	R-HSA-109581	5.043281e-01	0.297
G2/M Checkpoints	R-HSA-69481	2.858220e-01	0.544
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	5.022874e-01	0.299
Cell-cell junction organization	R-HSA-421270	2.684615e-01	0.571
Neurofascin interactions	R-HSA-447043	2.773553e-01	0.557
Vasopressin-like receptors	R-HSA-388479	4.987042e-01	0.302
ERK/MAPK targets	R-HSA-198753	3.509440e-01	0.455
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	1.707573e-01	0.768
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	4.752287e-01	0.323
Selective autophagy	R-HSA-9663891	5.597096e-01	0.252
Programmed Cell Death	R-HSA-5357801	5.968840e-01	0.224
Downstream signal transduction	R-HSA-186763	2.561822e-01	0.591
Signaling by FGFR1	R-HSA-5654736	6.034670e-01	0.219
Membrane Trafficking	R-HSA-199991	1.895573e-01	0.722
Activation of ATR in response to replication stress	R-HSA-176187	1.671551e-01	0.777
Mitochondrial biogenesis	R-HSA-1592230	3.426725e-01	0.465
Golgi-to-ER retrograde transport	R-HSA-8856688	4.389378e-01	0.358
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	4.791619e-01	0.320
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	3.044595e-01	0.516
CD209 (DC-SIGN) signaling	R-HSA-5621575	4.530995e-01	0.344
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	3.516105e-01	0.454
Macroautophagy	R-HSA-1632852	4.548052e-01	0.342
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	4.183700e-01	0.378
Post NMDA receptor activation events	R-HSA-438064	4.263466e-01	0.370
Resolution of Abasic Sites (AP sites)	R-HSA-73933	3.175390e-01	0.498
Signaling by NOTCH	R-HSA-157118	5.189114e-01	0.285
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	5.862245e-01	0.232
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	2.313720e-01	0.636
Negative regulation of MAPK pathway	R-HSA-5675221	4.948261e-01	0.306
G1/S Transition	R-HSA-69206	4.450014e-01	0.352
Developmental Biology	R-HSA-1266738	4.113661e-01	0.386
Inhibition of PKR	R-HSA-169131	2.055917e-01	0.687
Transport of connexins along the secretory pathway	R-HSA-190827	2.919548e-01	0.535
Manipulation of host energy metabolism	R-HSA-9636667	2.919548e-01	0.535
NrCAM interactions	R-HSA-447038	1.931718e-01	0.714
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	1.618408e-01	0.791
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	3.689335e-01	0.433
Cell-extracellular matrix interactions	R-HSA-446353	1.778786e-01	0.750
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	2.008563e-01	0.697
Signaling by AMER1 mutants	R-HSA-4839748	2.496417e-01	0.603
Regulation of PTEN localization	R-HSA-8948747	3.195091e-01	0.496
Activation of BIM and translocation to mitochondria	R-HSA-111446	4.375472e-01	0.359
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	3.610421e-01	0.442
Co-stimulation by ICOS	R-HSA-9927354	3.610421e-01	0.442
Regulation of KIT signaling	R-HSA-1433559	3.426227e-01	0.465
Unwinding of DNA	R-HSA-176974	4.015911e-01	0.396
Dopamine receptors	R-HSA-390651	4.987042e-01	0.302
Alanine metabolism	R-HSA-8964540	4.987042e-01	0.302
Viral Messenger RNA Synthesis	R-HSA-168325	1.777657e-01	0.750
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	3.346192e-01	0.475
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	2.244453e-01	0.649
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	5.532147e-01	0.257
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	3.829718e-01	0.417
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	4.874445e-01	0.312
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	4.874445e-01	0.312
Myogenesis	R-HSA-525793	5.022874e-01	0.299
Metalloprotease DUBs	R-HSA-5689901	5.022874e-01	0.299
Pentose phosphate pathway disease	R-HSA-6791465	6.018007e-01	0.221
Synthesis of PS	R-HSA-1483101	6.018007e-01	0.221
Sensory perception of salty taste	R-HSA-9730628	6.018007e-01	0.221
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	6.005371e-01	0.221
Cytoprotection by HMOX1	R-HSA-9707564	6.000019e-01	0.222
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	4.272976e-01	0.369
MAPK family signaling cascades	R-HSA-5683057	3.539301e-01	0.451
Organelle biogenesis and maintenance	R-HSA-1852241	5.941460e-01	0.226
Intrinsic Pathway for Apoptosis	R-HSA-109606	4.555511e-01	0.341
NOD1/2 Signaling Pathway	R-HSA-168638	5.088732e-01	0.293
Signaling by ERBB4	R-HSA-1236394	3.465890e-01	0.460
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	5.708718e-01	0.243
Signaling by PTK6	R-HSA-8848021	5.708718e-01	0.243
Receptor Mediated Mitophagy	R-HSA-8934903	4.408794e-01	0.356
Deubiquitination	R-HSA-5688426	1.899104e-01	0.721
Influenza Viral RNA Transcription and Replication	R-HSA-168273	2.714368e-01	0.566
Long-term potentiation	R-HSA-9620244	4.779179e-01	0.321
Rap1 signalling	R-HSA-392517	5.215090e-01	0.283
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	3.509657e-01	0.455
Activation of BH3-only proteins	R-HSA-114452	3.990267e-01	0.399
Oncogene Induced Senescence	R-HSA-2559585	5.299307e-01	0.276
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	2.469185e-01	0.607
Nuclear signaling by ERBB4	R-HSA-1251985	2.994965e-01	0.524
CHL1 interactions	R-HSA-447041	3.195091e-01	0.496
Activation of PUMA and translocation to mitochondria	R-HSA-139915	3.195091e-01	0.496
Muscarinic acetylcholine receptors	R-HSA-390648	5.532147e-01	0.257
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	4.153235e-01	0.382
Rab regulation of trafficking	R-HSA-9007101	3.426725e-01	0.465
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	6.018007e-01	0.221
Release of Hh-Np from the secreting cell	R-HSA-5362798	6.018007e-01	0.221
Oxidative Stress Induced Senescence	R-HSA-2559580	4.272976e-01	0.369
MAPK6/MAPK4 signaling	R-HSA-5687128	5.043034e-01	0.297
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	3.895227e-01	0.409
Netrin-1 signaling	R-HSA-373752	2.535573e-01	0.596
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	3.765433e-01	0.424
PI5P Regulates TP53 Acetylation	R-HSA-6811555	5.821540e-01	0.235
FLT3 Signaling	R-HSA-9607240	3.175390e-01	0.498
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	2.246542e-01	0.648
Diseases of DNA repair	R-HSA-9675135	2.857649e-01	0.544
Interleukin-15 signaling	R-HSA-8983432	5.494159e-01	0.260
Signaling by TGFBR3	R-HSA-9839373	4.280647e-01	0.368
Oligomerization of connexins into connexons	R-HSA-190704	2.919548e-01	0.535
Regulation of MITF-M dependent genes involved in invasion	R-HSA-9854909	1.931718e-01	0.714
Integration of viral DNA into host genomic DNA	R-HSA-175567	2.773553e-01	0.557
CASP5-mediated substrate cleavage	R-HSA-9960525	4.375472e-01	0.359
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	1.976201e-01	0.704
Sensory perception of sour taste	R-HSA-9729555	4.987042e-01	0.302
NADE modulates death signalling	R-HSA-205025	4.987042e-01	0.302
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	2.753705e-01	0.560
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	3.509440e-01	0.455
2-LTR circle formation	R-HSA-164843	4.408794e-01	0.356
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	2.857649e-01	0.544
Regulation of PTEN gene transcription	R-HSA-8943724	2.615970e-01	0.582
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	4.530995e-01	0.344
Sensing of DNA Double Strand Breaks	R-HSA-5693548	5.149130e-01	0.288
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	5.149130e-01	0.288
DNA strand elongation	R-HSA-69190	4.436649e-01	0.353
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	4.213491e-01	0.375
Host Interactions of HIV factors	R-HSA-162909	4.220712e-01	0.375
RNA Polymerase I Transcription Initiation	R-HSA-73762	5.141704e-01	0.289
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	5.751649e-01	0.240
Regulation of gene expression in beta cells	R-HSA-210745	5.721028e-01	0.243
Glutathione synthesis and recycling	R-HSA-174403	6.005371e-01	0.221
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	6.131031e-01	0.212
STING mediated induction of host immune responses	R-HSA-1834941	5.215090e-01	0.283
Transcriptional Regulation by VENTX	R-HSA-8853884	3.175390e-01	0.498
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	2.695232e-01	0.569
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	5.299307e-01	0.276
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	2.028839e-01	0.693
Histamine receptors	R-HSA-390650	4.375472e-01	0.359
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	3.547279e-01	0.450
PECAM1 interactions	R-HSA-210990	4.787019e-01	0.320
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	6.131031e-01	0.212
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	5.261437e-01	0.279
UCH proteinases	R-HSA-5689603	4.998780e-01	0.301
Lagging Strand Synthesis	R-HSA-69186	5.751649e-01	0.240
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	4.849734e-01	0.314
Diseases of Base Excision Repair	R-HSA-9605308	2.350466e-01	0.629
Specification of primordial germ cells	R-HSA-9827857	4.643538e-01	0.333
Signaling by TGFB family members	R-HSA-9006936	4.839488e-01	0.315
Early Phase of HIV Life Cycle	R-HSA-162594	5.751649e-01	0.240
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	3.689335e-01	0.433
Displacement of DNA glycosylase by APEX1	R-HSA-110357	3.195091e-01	0.496
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	4.375472e-01	0.359
CASP4-mediated substrate cleavage	R-HSA-9960519	4.375472e-01	0.359
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	4.043912e-01	0.393
Glucose metabolism	R-HSA-70326	2.568016e-01	0.590
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	4.656911e-01	0.332
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	5.022874e-01	0.299
Relaxin receptors	R-HSA-444821	6.018007e-01	0.221
Acetylcholine inhibits contraction of outer hair cells	R-HSA-9667769	6.018007e-01	0.221
Pyroptosis	R-HSA-5620971	5.494313e-01	0.260
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	5.821540e-01	0.235
MITF-M-dependent gene expression	R-HSA-9856651	1.690279e-01	0.772
Influenza Infection	R-HSA-168255	3.477703e-01	0.459
Zygotic genome activation (ZGA)	R-HSA-9819196	5.751649e-01	0.240
MITF-M-regulated melanocyte development	R-HSA-9730414	2.926044e-01	0.534
Gene Silencing by RNA	R-HSA-211000	2.174535e-01	0.663
PI Metabolism	R-HSA-1483255	3.248260e-01	0.488
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	4.024191e-01	0.395
Signaling by TGF-beta Receptor Complex	R-HSA-170834	2.674655e-01	0.573
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	1.931718e-01	0.714
NPAS4 regulates expression of target genes	R-HSA-9768919	1.976201e-01	0.704
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	4.153235e-01	0.382
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	6.018007e-01	0.221
Transcriptional Regulation by NPAS4	R-HSA-9634815	2.582569e-01	0.588
SARS-CoV-1-host interactions	R-HSA-9692914	4.905166e-01	0.309
G1/S-Specific Transcription	R-HSA-69205	3.749184e-01	0.426
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	4.043912e-01	0.393
Signaling by PDGFR in disease	R-HSA-9671555	2.028839e-01	0.693
Physiological factors	R-HSA-5578768	3.426227e-01	0.465
Depolymerization of the Nuclear Lamina	R-HSA-4419969	4.933323e-01	0.307
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	5.088732e-01	0.293
P2Y receptors	R-HSA-417957	6.131031e-01	0.212
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	2.492819e-01	0.603
tRNA processing in the nucleus	R-HSA-6784531	2.899680e-01	0.538
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	6.018007e-01	0.221
OAS antiviral response	R-HSA-8983711	5.494159e-01	0.260
Nectin/Necl trans heterodimerization	R-HSA-420597	5.532147e-01	0.257
Signaling by Leptin	R-HSA-2586552	4.408794e-01	0.356
Replication of the SARS-CoV-1 genome	R-HSA-9682706	5.821540e-01	0.235
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	5.494159e-01	0.260
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	6.131031e-01	0.212
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	4.933323e-01	0.307
Budding and maturation of HIV virion	R-HSA-162588	6.154471e-01	0.211
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	6.154471e-01	0.211
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	6.224539e-01	0.206
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	6.231362e-01	0.205
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	6.248906e-01	0.204
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	6.248906e-01	0.204
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	6.248906e-01	0.204
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	6.248906e-01	0.204
Eukaryotic Translation Elongation	R-HSA-156842	6.252462e-01	0.204
RAF/MAP kinase cascade	R-HSA-5673001	6.271089e-01	0.203
Inhibition of DNA recombination at telomere	R-HSA-9670095	6.283560e-01	0.202
Aggrephagy	R-HSA-9646399	6.283560e-01	0.202
RNA Polymerase I Promoter Clearance	R-HSA-73854	6.288727e-01	0.201
HDR through Homologous Recombination (HRR)	R-HSA-5685942	6.315604e-01	0.200
DNA Replication Pre-Initiation	R-HSA-69002	6.347117e-01	0.197
Extra-nuclear estrogen signaling	R-HSA-9009391	6.360559e-01	0.197
Signaling by WNT in cancer	R-HSA-4791275	6.360627e-01	0.197
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	6.360627e-01	0.197
Assembly of the pre-replicative complex	R-HSA-68867	6.377459e-01	0.195
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	6.398710e-01	0.194
SARS-CoV-1 Infection	R-HSA-9678108	6.399949e-01	0.194
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	6.412861e-01	0.193
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	6.422652e-01	0.192
Activation of BAD and translocation to mitochondria	R-HSA-111447	6.422652e-01	0.192
SHC1 events in EGFR signaling	R-HSA-180336	6.422652e-01	0.192
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	6.422652e-01	0.192
ERBB2 Regulates Cell Motility	R-HSA-6785631	6.422652e-01	0.192
Sema3A PAK dependent Axon repulsion	R-HSA-399954	6.422652e-01	0.192
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	6.422652e-01	0.192
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	6.422652e-01	0.192
Spry regulation of FGF signaling	R-HSA-1295596	6.422652e-01	0.192
Protein methylation	R-HSA-8876725	6.422652e-01	0.192
Formation of the anterior neural plate	R-HSA-9823739	6.422652e-01	0.192
IRF3-mediated induction of type I IFN	R-HSA-3270619	6.422652e-01	0.192
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	6.422652e-01	0.192
DNA Damage Reversal	R-HSA-73942	6.422652e-01	0.192
STAT5 Activation	R-HSA-9645135	6.451056e-01	0.190
Erythropoietin activates STAT5	R-HSA-9027283	6.451056e-01	0.190
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	6.451056e-01	0.190
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	6.451056e-01	0.190
G2/M DNA replication checkpoint	R-HSA-69478	6.451056e-01	0.190
Abacavir transmembrane transport	R-HSA-2161517	6.451056e-01	0.190
NADPH regeneration	R-HSA-389542	6.451056e-01	0.190
Leukotriene receptors	R-HSA-391906	6.451056e-01	0.190
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	6.464752e-01	0.189
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	6.464752e-01	0.189
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	6.482043e-01	0.188
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	6.482043e-01	0.188
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	6.482043e-01	0.188
Syndecan interactions	R-HSA-3000170	6.482043e-01	0.188
Growth hormone receptor signaling	R-HSA-982772	6.482043e-01	0.188
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	6.503810e-01	0.187
Regulation of beta-cell development	R-HSA-186712	6.503810e-01	0.187
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	6.559466e-01	0.183
Assembly of the ORC complex at the origin of replication	R-HSA-68616	6.559466e-01	0.183
G-protein beta:gamma signalling	R-HSA-397795	6.559466e-01	0.183
PI3K Cascade	R-HSA-109704	6.561814e-01	0.183
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	6.620676e-01	0.179
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	6.640280e-01	0.178
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	6.696628e-01	0.174
Defective GALNT12 causes CRCS1	R-HSA-5083636	6.696628e-01	0.174
Defective GALNT3 causes HFTC	R-HSA-5083625	6.696628e-01	0.174
WNT5A-dependent internalization of FZD4	R-HSA-5099900	6.696628e-01	0.174
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	6.696628e-01	0.174
Killing mechanisms	R-HSA-9664420	6.696628e-01	0.174
Negative regulation of FLT3	R-HSA-9706369	6.696628e-01	0.174
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	6.696628e-01	0.174
Thromboxane signalling through TP receptor	R-HSA-428930	6.704676e-01	0.174
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	6.704676e-01	0.174
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	6.704676e-01	0.174
Meiotic recombination	R-HSA-912446	6.720121e-01	0.173
Degradation of beta-catenin by the destruction complex	R-HSA-195253	6.738020e-01	0.171
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	6.738020e-01	0.171
Eukaryotic Translation Termination	R-HSA-72764	6.738758e-01	0.171
Striated Muscle Contraction	R-HSA-390522	6.750861e-01	0.171
MAPK1/MAPK3 signaling	R-HSA-5684996	6.767158e-01	0.170
Diseases of programmed cell death	R-HSA-9645723	6.774919e-01	0.169
Regulation of RUNX2 expression and activity	R-HSA-8939902	6.797527e-01	0.168
IRS-related events triggered by IGF1R	R-HSA-2428928	6.797527e-01	0.168
MAP kinase activation	R-HSA-450294	6.797527e-01	0.168
Signaling by MET	R-HSA-6806834	6.818612e-01	0.166
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	6.837033e-01	0.165
MET activates PI3K/AKT signaling	R-HSA-8851907	6.837033e-01	0.165
Glycoprotein hormones	R-HSA-209822	6.837033e-01	0.165
TRIF-mediated programmed cell death	R-HSA-2562578	6.837033e-01	0.165
IFNG signaling activates MAPKs	R-HSA-9732724	6.837033e-01	0.165
DAG1 core M1 glycosylations	R-HSA-8932506	6.837033e-01	0.165
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	6.837033e-01	0.165
NOSTRIN mediated eNOS trafficking	R-HSA-203641	6.837033e-01	0.165
Nef Mediated CD4 Down-regulation	R-HSA-167590	6.837033e-01	0.165
Activated NTRK2 signals through CDK5	R-HSA-9032845	6.837033e-01	0.165
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	6.837033e-01	0.165
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	6.837033e-01	0.165
Ca2+ activated K+ channels	R-HSA-1296052	6.837033e-01	0.165
VLDL clearance	R-HSA-8964046	6.837033e-01	0.165
Netrin mediated repulsion signals	R-HSA-418886	6.837033e-01	0.165
Cation-coupled Chloride cotransporters	R-HSA-426117	6.837033e-01	0.165
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	6.837033e-01	0.165
COPI-mediated anterograde transport	R-HSA-6807878	6.854408e-01	0.164
Chromosome Maintenance	R-HSA-73886	6.869340e-01	0.163
Nuclear events mediated by NFE2L2	R-HSA-9759194	6.869340e-01	0.163
RNA Polymerase I Promoter Escape	R-HSA-73772	6.873694e-01	0.163
Neuronal System	R-HSA-112316	6.895501e-01	0.161
Cellular responses to mechanical stimuli	R-HSA-9855142	6.897236e-01	0.161
Acyl chain remodelling of PS	R-HSA-1482801	6.916788e-01	0.160
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	6.934732e-01	0.159
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	6.934732e-01	0.159
GRB2 events in ERBB2 signaling	R-HSA-1963640	6.953348e-01	0.158
Phase 2 - plateau phase	R-HSA-5576893	6.953348e-01	0.158
Fibronectin matrix formation	R-HSA-1566977	6.953348e-01	0.158
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	6.953348e-01	0.158
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	6.953348e-01	0.158
Synthesis of PG	R-HSA-1483148	6.953348e-01	0.158
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	6.953348e-01	0.158
Signaling by SCF-KIT	R-HSA-1433557	6.973925e-01	0.157
Base Excision Repair	R-HSA-73884	7.012269e-01	0.154
Signaling by Hedgehog	R-HSA-5358351	7.014029e-01	0.154
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	7.022462e-01	0.154
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	7.022462e-01	0.154
Signaling by FGFR	R-HSA-190236	7.078221e-01	0.150
PTEN Regulation	R-HSA-6807070	7.106348e-01	0.148
Signaling by FLT3 fusion proteins	R-HSA-9703465	7.118439e-01	0.148
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	7.118439e-01	0.148
Pre-NOTCH Transcription and Translation	R-HSA-1912408	7.126752e-01	0.147
EPHB-mediated forward signaling	R-HSA-3928662	7.131915e-01	0.147
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	7.141613e-01	0.146
HCMV Late Events	R-HSA-9610379	7.145867e-01	0.146
DAG1 core M2 glycosylations	R-HSA-8932504	7.181053e-01	0.144
Activated NTRK2 signals through PI3K	R-HSA-9028335	7.181053e-01	0.144
Activation of RAS in B cells	R-HSA-1169092	7.181053e-01	0.144
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	7.181053e-01	0.144
Adrenoceptors	R-HSA-390696	7.181053e-01	0.144
Regulation by c-FLIP	R-HSA-3371378	7.181053e-01	0.144
Fructose biosynthesis	R-HSA-5652227	7.181053e-01	0.144
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	7.181053e-01	0.144
SLC-mediated bile acid transport	R-HSA-9958517	7.181053e-01	0.144
Nucleotide salvage defects	R-HSA-9734207	7.181053e-01	0.144
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	7.181053e-01	0.144
Dimerization of procaspase-8	R-HSA-69416	7.181053e-01	0.144
TGFBR3 PTM regulation	R-HSA-9839383	7.181053e-01	0.144
Alpha-defensins	R-HSA-1462054	7.181053e-01	0.144
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	7.181053e-01	0.144
Sodium/Proton exchangers	R-HSA-425986	7.181053e-01	0.144
Activated NTRK2 signals through FYN	R-HSA-9032500	7.181053e-01	0.144
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	7.193323e-01	0.143
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	7.193323e-01	0.143
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	7.193323e-01	0.143
Regulation of NPAS4 gene expression	R-HSA-9768759	7.193323e-01	0.143
Replication of the SARS-CoV-2 genome	R-HSA-9694686	7.193323e-01	0.143
Cellular response to starvation	R-HSA-9711097	7.230982e-01	0.141
Stimuli-sensing channels	R-HSA-2672351	7.244070e-01	0.140
Signaling by FGFR in disease	R-HSA-1226099	7.252866e-01	0.139
Calmodulin induced events	R-HSA-111933	7.279839e-01	0.138
CaM pathway	R-HSA-111997	7.279839e-01	0.138
GPVI-mediated activation cascade	R-HSA-114604	7.279839e-01	0.138
Nucleosome assembly	R-HSA-774815	7.283984e-01	0.138
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	7.283984e-01	0.138
DAG and IP3 signaling	R-HSA-1489509	7.283984e-01	0.138
Signaling by FGFR3 in disease	R-HSA-5655332	7.309759e-01	0.136
Maturation of hRSV A proteins	R-HSA-9828806	7.309759e-01	0.136
EPH-Ephrin signaling	R-HSA-2682334	7.347155e-01	0.134
Signaling by Insulin receptor	R-HSA-74752	7.347155e-01	0.134
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	7.354353e-01	0.133
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	7.354353e-01	0.133
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	7.354353e-01	0.133
HCMV Early Events	R-HSA-9609690	7.379450e-01	0.132
Selenocysteine synthesis	R-HSA-2408557	7.394672e-01	0.131
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	7.417159e-01	0.130
RNA Polymerase III Transcription Termination	R-HSA-73980	7.417159e-01	0.130
Tie2 Signaling	R-HSA-210993	7.417159e-01	0.130
Nucleotide-like (purinergic) receptors	R-HSA-418038	7.417159e-01	0.130
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	7.417159e-01	0.130
KEAP1-NFE2L2 pathway	R-HSA-9755511	7.425668e-01	0.129
Condensation of Prophase Chromosomes	R-HSA-2299718	7.430141e-01	0.129
Ion homeostasis	R-HSA-5578775	7.439563e-01	0.128
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	7.439563e-01	0.128
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	7.487672e-01	0.126
WNT mediated activation of DVL	R-HSA-201688	7.487672e-01	0.126
CASP8 activity is inhibited	R-HSA-5218900	7.487672e-01	0.126
Activation of the AP-1 family of transcription factors	R-HSA-450341	7.487672e-01	0.126
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	7.487672e-01	0.126
ARMS-mediated activation	R-HSA-170984	7.487672e-01	0.126
Regulation of signaling by NODAL	R-HSA-1433617	7.487672e-01	0.126
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	7.487672e-01	0.126
Butyrophilin (BTN) family interactions	R-HSA-8851680	7.487672e-01	0.126
Insulin receptor recycling	R-HSA-77387	7.490931e-01	0.125
Negative regulation of FGFR3 signaling	R-HSA-5654732	7.490931e-01	0.125
Regulation of CDH1 Function	R-HSA-9764561	7.568837e-01	0.121
IRS-mediated signalling	R-HSA-112399	7.568837e-01	0.121
DNA Replication	R-HSA-69306	7.587671e-01	0.120
Viral mRNA Translation	R-HSA-192823	7.592526e-01	0.120
Depurination	R-HSA-73927	7.595044e-01	0.119
Developmental Cell Lineages	R-HSA-9734767	7.596063e-01	0.119
Cilium Assembly	R-HSA-5617833	7.621037e-01	0.118
PI-3K cascade:FGFR3	R-HSA-5654710	7.625527e-01	0.118
IKK complex recruitment mediated by RIP1	R-HSA-937041	7.625527e-01	0.118
Specification of the neural plate border	R-HSA-9834899	7.625527e-01	0.118
Signaling by FGFR2 IIIa TM	R-HSA-8851708	7.625527e-01	0.118
Regulation of signaling by CBL	R-HSA-912631	7.625527e-01	0.118
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	7.625527e-01	0.118
DARPP-32 events	R-HSA-180024	7.662187e-01	0.116
Negative regulation of FGFR4 signaling	R-HSA-5654733	7.662187e-01	0.116
Platelet calcium homeostasis	R-HSA-418360	7.662187e-01	0.116
Response of endothelial cells to shear stress	R-HSA-9860931	7.687486e-01	0.114
Regulated Necrosis	R-HSA-5218859	7.696824e-01	0.114
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	7.696824e-01	0.114
SARS-CoV-2-host interactions	R-HSA-9705683	7.731116e-01	0.112
Stabilization of p53	R-HSA-69541	7.741667e-01	0.111
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	7.741667e-01	0.111
MAPK3 (ERK1) activation	R-HSA-110056	7.760957e-01	0.110
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	7.760957e-01	0.110
Pexophagy	R-HSA-9664873	7.760957e-01	0.110
Regulation of CDH11 function	R-HSA-9762292	7.760957e-01	0.110
Peptide hormone biosynthesis	R-HSA-209952	7.760957e-01	0.110
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	7.760957e-01	0.110
EGFR Transactivation by Gastrin	R-HSA-2179392	7.760957e-01	0.110
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	7.760957e-01	0.110
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	7.760957e-01	0.110
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	7.760957e-01	0.110
Arachidonate production from DAG	R-HSA-426048	7.760957e-01	0.110
Maturation of spike protein	R-HSA-9683686	7.760957e-01	0.110
Tandem pore domain potassium channels	R-HSA-1296346	7.760957e-01	0.110
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	7.815222e-01	0.107
Sensory processing of sound	R-HSA-9659379	7.815222e-01	0.107
Regulation of PD-L1(CD274) translation	R-HSA-9909620	7.819143e-01	0.107
PI-3K cascade:FGFR4	R-HSA-5654720	7.819143e-01	0.107
Signaling by NODAL	R-HSA-1181150	7.819143e-01	0.107
Nephrin family interactions	R-HSA-373753	7.819143e-01	0.107
Protein hydroxylation	R-HSA-9629569	7.819143e-01	0.107
Signal transduction by L1	R-HSA-445144	7.819143e-01	0.107
Negative regulation of MET activity	R-HSA-6807004	7.819143e-01	0.107
Eicosanoid ligand-binding receptors	R-HSA-391903	7.819143e-01	0.107
DAP12 signaling	R-HSA-2424491	7.823797e-01	0.107
DNA Damage Bypass	R-HSA-73893	7.833565e-01	0.106
Gap junction trafficking and regulation	R-HSA-157858	7.833565e-01	0.106
Degradation of CDH1	R-HSA-9766229	7.833565e-01	0.106
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	7.833565e-01	0.106
p53-Dependent G1 DNA Damage Response	R-HSA-69563	7.833565e-01	0.106
ER to Golgi Anterograde Transport	R-HSA-199977	7.856876e-01	0.105
Reproduction	R-HSA-1474165	7.868720e-01	0.104
Regulation of RUNX3 expression and activity	R-HSA-8941858	7.881149e-01	0.103
Attenuation phase	R-HSA-3371568	7.881149e-01	0.103
Formation of Incision Complex in GG-NER	R-HSA-5696395	7.881149e-01	0.103
Negative regulation of NOTCH4 signaling	R-HSA-9604323	7.881149e-01	0.103
Interleukin-17 signaling	R-HSA-448424	7.916502e-01	0.101
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	7.916848e-01	0.101
HCMV Infection	R-HSA-9609646	7.932953e-01	0.101
Cardiac conduction	R-HSA-5576891	7.947155e-01	0.100
Regulation of RAS by GAPs	R-HSA-5658442	7.956601e-01	0.099
Signaling by FGFR2 in disease	R-HSA-5655253	7.956601e-01	0.099
EGFR downregulation	R-HSA-182971	7.976060e-01	0.098
Cargo concentration in the ER	R-HSA-5694530	7.976060e-01	0.098
Evasion by RSV of host interferon responses	R-HSA-9833109	7.976060e-01	0.098
TP53 Regulates Metabolic Genes	R-HSA-5628897	7.977016e-01	0.098
SHC-mediated cascade:FGFR3	R-HSA-5654704	7.998750e-01	0.097
Signalling to RAS	R-HSA-167044	7.998750e-01	0.097
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	8.004529e-01	0.097
DAG1 core M3 glycosylations	R-HSA-8932505	8.004529e-01	0.097
Ionotropic activity of kainate receptors	R-HSA-451306	8.004529e-01	0.097
vRNA Synthesis	R-HSA-192814	8.004529e-01	0.097
Hormone ligand-binding receptors	R-HSA-375281	8.004529e-01	0.097
Synthesis of PI	R-HSA-1483226	8.004529e-01	0.097
RHOBTB3 ATPase cycle	R-HSA-9706019	8.004529e-01	0.097
Bicarbonate transporters	R-HSA-425381	8.004529e-01	0.097
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	8.004529e-01	0.097
Chylomicron assembly	R-HSA-8963888	8.004529e-01	0.097
Transport of RCbl within the body	R-HSA-9758890	8.004529e-01	0.097
Prostanoid ligand receptors	R-HSA-391908	8.004529e-01	0.097
Interleukin-2 signaling	R-HSA-9020558	8.004529e-01	0.097
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	8.013654e-01	0.096
Maturation of spike protein	R-HSA-9694548	8.013654e-01	0.096
VEGFA-VEGFR2 Pathway	R-HSA-4420097	8.057760e-01	0.094
HSF1-dependent transactivation	R-HSA-3371571	8.074083e-01	0.093
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	8.139363e-01	0.089
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	8.139363e-01	0.089
Signaling by PDGF	R-HSA-186797	8.143490e-01	0.089
SHC-mediated cascade:FGFR4	R-HSA-5654719	8.165104e-01	0.088
Listeria monocytogenes entry into host cells	R-HSA-8876384	8.165104e-01	0.088
Hedgehog 'off' state	R-HSA-5610787	8.195849e-01	0.086
Switching of origins to a post-replicative state	R-HSA-69052	8.215824e-01	0.085
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	8.221617e-01	0.085
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	8.221617e-01	0.085
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	8.221617e-01	0.085
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	8.221617e-01	0.085
Anchoring fibril formation	R-HSA-2214320	8.221617e-01	0.085
rRNA modification in the nucleus and cytosol	R-HSA-6790901	8.244539e-01	0.084
Regulation of necroptotic cell death	R-HSA-5675482	8.253862e-01	0.083
FGFR1 mutant receptor activation	R-HSA-1839124	8.253862e-01	0.083
Negative regulation of FGFR1 signaling	R-HSA-5654726	8.253862e-01	0.083
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	8.253862e-01	0.083
Ca-dependent events	R-HSA-111996	8.258470e-01	0.083
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	8.258470e-01	0.083
Cleavage of the damaged pyrimidine	R-HSA-110329	8.258470e-01	0.083
Depyrimidination	R-HSA-73928	8.258470e-01	0.083
Golgi Associated Vesicle Biogenesis	R-HSA-432722	8.292867e-01	0.081
Signaling by NOTCH4	R-HSA-9013694	8.307784e-01	0.081
PI-3K cascade:FGFR1	R-HSA-5654689	8.318962e-01	0.080
RAF-independent MAPK1/3 activation	R-HSA-112409	8.318962e-01	0.080
LDL clearance	R-HSA-8964038	8.318962e-01	0.080
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	8.318962e-01	0.080
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	8.341164e-01	0.079
Defective pyroptosis	R-HSA-9710421	8.371184e-01	0.077
Ub-specific processing proteases	R-HSA-5689880	8.373761e-01	0.077
Effects of PIP2 hydrolysis	R-HSA-114508	8.380097e-01	0.077
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	8.380097e-01	0.077
Base-Excision Repair, AP Site Formation	R-HSA-73929	8.394439e-01	0.076
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	8.415099e-01	0.075
GRB2 events in EGFR signaling	R-HSA-179812	8.415099e-01	0.075
Serotonin clearance from the synaptic cleft	R-HSA-380615	8.415099e-01	0.075
VLDLR internalisation and degradation	R-HSA-8866427	8.415099e-01	0.075
MET activates RAS signaling	R-HSA-8851805	8.415099e-01	0.075
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	8.415099e-01	0.075
Regulation of IFNG signaling	R-HSA-877312	8.415099e-01	0.075
Regulation of PTEN mRNA translation	R-HSA-8943723	8.461074e-01	0.073
Interleukin receptor SHC signaling	R-HSA-912526	8.461074e-01	0.073
Termination of O-glycan biosynthesis	R-HSA-977068	8.461074e-01	0.073
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	8.461074e-01	0.073
Carnitine shuttle	R-HSA-200425	8.461074e-01	0.073
Amine ligand-binding receptors	R-HSA-375280	8.477722e-01	0.072
Negative regulation of FGFR2 signaling	R-HSA-5654727	8.498369e-01	0.071
Hyaluronan metabolism	R-HSA-2142845	8.498369e-01	0.071
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	8.499786e-01	0.071
Interferon Signaling	R-HSA-913531	8.510558e-01	0.070
Vesicle-mediated transport	R-HSA-5653656	8.512747e-01	0.070
Fanconi Anemia Pathway	R-HSA-6783310	8.578307e-01	0.067
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	8.587541e-01	0.066
CD28 dependent Vav1 pathway	R-HSA-389359	8.587541e-01	0.066
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	8.587541e-01	0.066
Platelet Adhesion to exposed collagen	R-HSA-75892	8.587541e-01	0.066
Chylomicron remodeling	R-HSA-8963901	8.587541e-01	0.066
Membrane binding and targetting of GAG proteins	R-HSA-174490	8.587541e-01	0.066
Diseases of nucleotide metabolism	R-HSA-9735804	8.587541e-01	0.066
rRNA modification in the mitochondrion	R-HSA-6793080	8.587541e-01	0.066
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	8.587541e-01	0.066
Maturation of nucleoprotein	R-HSA-9683610	8.587541e-01	0.066
SHC-mediated cascade:FGFR1	R-HSA-5654688	8.592173e-01	0.066
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	8.592173e-01	0.066
Plasma lipoprotein assembly	R-HSA-8963898	8.592173e-01	0.066
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	8.592173e-01	0.066
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	8.635893e-01	0.064
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	8.673168e-01	0.062
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	8.673168e-01	0.062
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	8.685552e-01	0.061
Regulation of T cell activation by CD28 family	R-HSA-388841	8.707402e-01	0.060
FLT3 signaling in disease	R-HSA-9682385	8.712489e-01	0.060
Triglyceride catabolism	R-HSA-163560	8.712489e-01	0.060
PI-3K cascade:FGFR2	R-HSA-5654695	8.712974e-01	0.060
VEGFR2 mediated cell proliferation	R-HSA-5218921	8.712974e-01	0.060
Formation of the nephric duct	R-HSA-9830364	8.712974e-01	0.060
MicroRNA (miRNA) biogenesis	R-HSA-203927	8.712974e-01	0.060
Glycogen breakdown (glycogenolysis)	R-HSA-70221	8.712974e-01	0.060
Hyaluronan degradation	R-HSA-2160916	8.712974e-01	0.060
Telomere Maintenance	R-HSA-157579	8.718924e-01	0.060
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	8.741229e-01	0.058
Synthesis of IPs in the nucleus	R-HSA-1855191	8.741229e-01	0.058
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	8.741229e-01	0.058
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	8.741229e-01	0.058
Vitamin B2 (riboflavin) metabolism	R-HSA-196843	8.741229e-01	0.058
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.741229e-01	0.058
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	8.741229e-01	0.058
Non-canonical inflammasome activation	R-HSA-9686114	8.741229e-01	0.058
HDL assembly	R-HSA-8963896	8.741229e-01	0.058
Signal regulatory protein family interactions	R-HSA-391160	8.741229e-01	0.058
Zinc transporters	R-HSA-435354	8.741229e-01	0.058
Interferon alpha/beta signaling	R-HSA-909733	8.747614e-01	0.058
Early SARS-CoV-2 Infection Events	R-HSA-9772572	8.752089e-01	0.058
Synthesis of DNA	R-HSA-69239	8.761950e-01	0.057
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	8.762536e-01	0.057
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	8.762536e-01	0.057
PKR-mediated signaling	R-HSA-9833482	8.783007e-01	0.056
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	8.784043e-01	0.056
Signaling by VEGF	R-HSA-194138	8.794387e-01	0.056
TRAF6 mediated IRF7 activation	R-HSA-933541	8.809070e-01	0.055
SIRT1 negatively regulates rRNA expression	R-HSA-427359	8.809070e-01	0.055
Cleavage of the damaged purine	R-HSA-110331	8.809070e-01	0.055
Collagen chain trimerization	R-HSA-8948216	8.809070e-01	0.055
Neurotransmitter release cycle	R-HSA-112310	8.811278e-01	0.055
MET activates PTK2 signaling	R-HSA-8874081	8.824164e-01	0.054
Suppression of phagosomal maturation	R-HSA-9637687	8.824164e-01	0.054
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	8.824164e-01	0.054
Extension of Telomeres	R-HSA-180786	8.830140e-01	0.054
Regulation of PD-L1(CD274) expression	R-HSA-9909648	8.835396e-01	0.054
Intraflagellar transport	R-HSA-5620924	8.846644e-01	0.053
GPER1 signaling	R-HSA-9634597	8.846644e-01	0.053
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	8.878203e-01	0.052
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	8.878203e-01	0.052
RNA Polymerase III Chain Elongation	R-HSA-73780	8.878203e-01	0.052
Protein lipoylation	R-HSA-9857492	8.878203e-01	0.052
Telomere C-strand synthesis initiation	R-HSA-174430	8.878203e-01	0.052
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	8.878203e-01	0.052
p38MAPK events	R-HSA-171007	8.878203e-01	0.052
Lysosphingolipid and LPA receptors	R-HSA-419408	8.878203e-01	0.052
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	8.878203e-01	0.052
Other semaphorin interactions	R-HSA-416700	8.878203e-01	0.052
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	8.899142e-01	0.051
Muscle contraction	R-HSA-397014	8.899142e-01	0.051
RIPK1-mediated regulated necrosis	R-HSA-5213460	8.899144e-01	0.051
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	8.902912e-01	0.050
Regulation of mitotic cell cycle	R-HSA-453276	8.902912e-01	0.050
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	8.902912e-01	0.050
SHC-mediated cascade:FGFR2	R-HSA-5654699	8.926405e-01	0.049
Packaging Of Telomere Ends	R-HSA-171306	8.926405e-01	0.049
Signaling by BMP	R-HSA-201451	8.926405e-01	0.049
Cristae formation	R-HSA-8949613	8.926405e-01	0.049
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	8.926405e-01	0.049
Cellular responses to stress	R-HSA-2262752	8.930260e-01	0.049
MyD88-independent TLR4 cascade	R-HSA-166166	8.933155e-01	0.049
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	8.933155e-01	0.049
SARS-CoV-2 Infection	R-HSA-9694516	8.946058e-01	0.048
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	8.968229e-01	0.047
Aquaporin-mediated transport	R-HSA-445717	8.973759e-01	0.047
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	8.983066e-01	0.047
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	9.000280e-01	0.046
Phase 4 - resting membrane potential	R-HSA-5576886	9.000280e-01	0.046
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	9.000280e-01	0.046
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	9.000280e-01	0.046
Mineralocorticoid biosynthesis	R-HSA-193993	9.000280e-01	0.046
Atorvastatin ADME	R-HSA-9754706	9.000280e-01	0.046
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.015975e-01	0.045
Telomere Extension By Telomerase	R-HSA-171319	9.020326e-01	0.045
Ca2+ pathway	R-HSA-4086398	9.030189e-01	0.044
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	9.039659e-01	0.044
NCAM signaling for neurite out-growth	R-HSA-375165	9.039659e-01	0.044
Generation of second messenger molecules	R-HSA-202433	9.061179e-01	0.043
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	9.065502e-01	0.043
Pre-NOTCH Expression and Processing	R-HSA-1912422	9.084306e-01	0.042
Collagen formation	R-HSA-1474290	9.097755e-01	0.041
G1/S DNA Damage Checkpoints	R-HSA-69615	9.101838e-01	0.041
Signaling by CSF3 (G-CSF)	R-HSA-9674555	9.106528e-01	0.041
Gastrulation	R-HSA-9758941	9.106744e-01	0.041
SHC1 events in ERBB4 signaling	R-HSA-1250347	9.109078e-01	0.041
Glycine degradation	R-HSA-6783984	9.109078e-01	0.041
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	9.109078e-01	0.041
Galactose catabolism	R-HSA-70370	9.109078e-01	0.041
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	9.109078e-01	0.041
Coenzyme A biosynthesis	R-HSA-196783	9.109078e-01	0.041
Response to metal ions	R-HSA-5660526	9.109078e-01	0.041
tRNA modification in the mitochondrion	R-HSA-6787450	9.109078e-01	0.041
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	9.135081e-01	0.039
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.135081e-01	0.039
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	9.135081e-01	0.039
Cellular response to chemical stress	R-HSA-9711123	9.140052e-01	0.039
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	9.147392e-01	0.039
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.167216e-01	0.038
tRNA processing	R-HSA-72306	9.167216e-01	0.038
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.185577e-01	0.037
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	9.196317e-01	0.036
Amino acids regulate mTORC1	R-HSA-9639288	9.196317e-01	0.036
Smooth Muscle Contraction	R-HSA-445355	9.196317e-01	0.036
Degradation of GLI1 by the proteasome	R-HSA-5610780	9.201305e-01	0.036
Intra-Golgi traffic	R-HSA-6811438	9.201305e-01	0.036
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.201305e-01	0.036
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	9.206041e-01	0.036
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	9.206041e-01	0.036
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	9.206041e-01	0.036
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	9.206041e-01	0.036
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	9.206041e-01	0.036
Regulation of FZD by ubiquitination	R-HSA-4641263	9.206041e-01	0.036
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	9.206041e-01	0.036
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	9.206041e-01	0.036
Choline catabolism	R-HSA-6798163	9.206041e-01	0.036
Uptake and function of anthrax toxins	R-HSA-5210891	9.206041e-01	0.036
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	9.215682e-01	0.035
Cellular responses to stimuli	R-HSA-8953897	9.219636e-01	0.035
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.221502e-01	0.035
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	9.253637e-01	0.034
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	9.258010e-01	0.033
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.258010e-01	0.033
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.267663e-01	0.033
Transport of connexons to the plasma membrane	R-HSA-190872	9.292457e-01	0.032
PKA activation	R-HSA-163615	9.292457e-01	0.032
Mismatch Repair	R-HSA-5358508	9.292457e-01	0.032
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	9.292457e-01	0.032
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	9.292457e-01	0.032
Platelet sensitization by LDL	R-HSA-432142	9.292457e-01	0.032
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	9.307249e-01	0.031
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	9.307249e-01	0.031
Response of Mtb to phagocytosis	R-HSA-9637690	9.322061e-01	0.030
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	9.322061e-01	0.030
MyD88 cascade initiated on plasma membrane	R-HSA-975871	9.323195e-01	0.030
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	9.323195e-01	0.030
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	9.323195e-01	0.030
PPARA activates gene expression	R-HSA-1989781	9.323609e-01	0.030
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	9.357354e-01	0.029
Crosslinking of collagen fibrils	R-HSA-2243919	9.369471e-01	0.028
E2F mediated regulation of DNA replication	R-HSA-113510	9.369471e-01	0.028
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	9.369471e-01	0.028
Diseases of hemostasis	R-HSA-9671793	9.369471e-01	0.028
HDL remodeling	R-HSA-8964058	9.369471e-01	0.028
Maturation of nucleoprotein	R-HSA-9694631	9.369471e-01	0.028
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	9.369471e-01	0.028
Other interleukin signaling	R-HSA-449836	9.369471e-01	0.028
The NLRP3 inflammasome	R-HSA-844456	9.369471e-01	0.028
Gap junction trafficking	R-HSA-190828	9.375914e-01	0.028
DAP12 interactions	R-HSA-2172127	9.375914e-01	0.028
Recycling of bile acids and salts	R-HSA-159418	9.385007e-01	0.028
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.387685e-01	0.027
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.408465e-01	0.026
Ribosome-associated quality control	R-HSA-9948299	9.418237e-01	0.026
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.438107e-01	0.025
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	9.438107e-01	0.025
Post-chaperonin tubulin folding pathway	R-HSA-389977	9.438107e-01	0.025
Pregnenolone biosynthesis	R-HSA-196108	9.438107e-01	0.025
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.440487e-01	0.025
Miscellaneous transport and binding events	R-HSA-5223345	9.440487e-01	0.025
Heme degradation	R-HSA-189483	9.440487e-01	0.025
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	9.446195e-01	0.025
Triglyceride metabolism	R-HSA-8979227	9.488536e-01	0.023
Signaling by NOTCH2	R-HSA-1980145	9.491179e-01	0.023
Calnexin/calreticulin cycle	R-HSA-901042	9.491179e-01	0.023
Mitophagy	R-HSA-5205647	9.491179e-01	0.023
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	9.493477e-01	0.023
Matriglycan biosynthesis on DAG1	R-HSA-9939291	9.499275e-01	0.022
G-protein activation	R-HSA-202040	9.499275e-01	0.022
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	9.499275e-01	0.022
PKA-mediated phosphorylation of CREB	R-HSA-111931	9.499275e-01	0.022
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	9.499275e-01	0.022
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.499275e-01	0.022
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	9.499275e-01	0.022
Transmission across Chemical Synapses	R-HSA-112315	9.506529e-01	0.022
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	9.514620e-01	0.022
Synthesis of PC	R-HSA-1483191	9.514620e-01	0.022
trans-Golgi Network Vesicle Budding	R-HSA-199992	9.519818e-01	0.021
Signaling by Interleukins	R-HSA-449147	9.527466e-01	0.021
Opioid Signalling	R-HSA-111885	9.527541e-01	0.021
Platelet activation, signaling and aggregation	R-HSA-76002	9.527987e-01	0.021
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	9.537470e-01	0.021
PERK regulates gene expression	R-HSA-381042	9.537470e-01	0.021
Phospholipid metabolism	R-HSA-1483257	9.542996e-01	0.020
FRS-mediated FGFR3 signaling	R-HSA-5654706	9.553787e-01	0.020
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	9.553787e-01	0.020
Molybdenum cofactor biosynthesis	R-HSA-947581	9.553787e-01	0.020
Assembly Of The HIV Virion	R-HSA-175474	9.553787e-01	0.020
Androgen biosynthesis	R-HSA-193048	9.553787e-01	0.020
Gluconeogenesis	R-HSA-70263	9.554062e-01	0.020
PLC beta mediated events	R-HSA-112043	9.561827e-01	0.019
Collagen degradation	R-HSA-1442490	9.561827e-01	0.019
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	9.575319e-01	0.019
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	9.579715e-01	0.019
Lysosome Vesicle Biogenesis	R-HSA-432720	9.579715e-01	0.019
FGFR2 mutant receptor activation	R-HSA-1839126	9.579715e-01	0.019
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.585812e-01	0.018
Cytokine Signaling in Immune system	R-HSA-1280215	9.586430e-01	0.018
FRS-mediated FGFR4 signaling	R-HSA-5654712	9.602368e-01	0.018
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	9.602368e-01	0.018
Signaling by KIT in disease	R-HSA-9669938	9.602368e-01	0.018
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.602368e-01	0.018
Regulation of IFNA/IFNB signaling	R-HSA-912694	9.602368e-01	0.018
Reactions specific to the complex N-glycan synthesis pathway	R-HSA-975578	9.602368e-01	0.018
Fructose metabolism	R-HSA-5652084	9.602368e-01	0.018
Ethanol oxidation	R-HSA-71384	9.602368e-01	0.018
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.602368e-01	0.018
XBP1(S) activates chaperone genes	R-HSA-381038	9.613298e-01	0.017
Non-integrin membrane-ECM interactions	R-HSA-3000171	9.613654e-01	0.017
Protein ubiquitination	R-HSA-8852135	9.613654e-01	0.017
Degradation of DVL	R-HSA-4641258	9.618248e-01	0.017
Voltage gated Potassium channels	R-HSA-1296072	9.618248e-01	0.017
CLEC7A (Dectin-1) signaling	R-HSA-5607764	9.620045e-01	0.017
Potassium Channels	R-HSA-1296071	9.620045e-01	0.017
SLC transporter disorders	R-HSA-5619102	9.625748e-01	0.017
Interleukin-12 signaling	R-HSA-9020591	9.640983e-01	0.016
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	9.645662e-01	0.016
Organic anion transport by SLCO transporters	R-HSA-879518	9.645662e-01	0.016
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.653376e-01	0.015
SLC-mediated transport of inorganic anions	R-HSA-9958790	9.653376e-01	0.015
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	9.653727e-01	0.015
Co-inhibition by PD-1	R-HSA-389948	9.661417e-01	0.015
Translation of Structural Proteins	R-HSA-9694635	9.666522e-01	0.015
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.671193e-01	0.015
MyD88 dependent cascade initiated on endosome	R-HSA-975155	9.674968e-01	0.014
Orc1 removal from chromatin	R-HSA-68949	9.683696e-01	0.014
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	9.683696e-01	0.014
TRAF6 mediated NF-kB activation	R-HSA-933542	9.684244e-01	0.014
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	9.684244e-01	0.014
Synthesis of dolichyl-phosphate	R-HSA-446199	9.684244e-01	0.014
Complex III assembly	R-HSA-9865881	9.684244e-01	0.014
TNFs bind their physiological receptors	R-HSA-5669034	9.684244e-01	0.014
Plasma lipoprotein clearance	R-HSA-8964043	9.685382e-01	0.014
Transport to the Golgi and subsequent modification	R-HSA-948021	9.692681e-01	0.014
Regulation of PTEN stability and activity	R-HSA-8948751	9.710030e-01	0.013
Interleukin-2 family signaling	R-HSA-451927	9.714531e-01	0.013
Glycogen metabolism	R-HSA-8982491	9.714531e-01	0.013
FRS-mediated FGFR1 signaling	R-HSA-5654693	9.718628e-01	0.012
Tight junction interactions	R-HSA-420029	9.718628e-01	0.012
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	9.718628e-01	0.012
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.718628e-01	0.012
Laminin interactions	R-HSA-3000157	9.718628e-01	0.012
G-protein mediated events	R-HSA-112040	9.727451e-01	0.012
IRE1alpha activates chaperones	R-HSA-381070	9.746079e-01	0.011
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.748558e-01	0.011
Abacavir ADME	R-HSA-2161522	9.749269e-01	0.011
Selenoamino acid metabolism	R-HSA-2408522	9.753810e-01	0.011
Paracetamol ADME	R-HSA-9753281	9.756593e-01	0.011
Protein folding	R-HSA-391251	9.763596e-01	0.010
Translation of Structural Proteins	R-HSA-9683701	9.765206e-01	0.010
Processive synthesis on the C-strand of the telomere	R-HSA-174414	9.776575e-01	0.010
EPHA-mediated growth cone collapse	R-HSA-3928663	9.776575e-01	0.010
Triglyceride biosynthesis	R-HSA-75109	9.776575e-01	0.010
ER Quality Control Compartment (ERQC)	R-HSA-901032	9.776575e-01	0.010
Synthesis of PE	R-HSA-1483213	9.776575e-01	0.010
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.776575e-01	0.010
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.777119e-01	0.010
COPII-mediated vesicle transport	R-HSA-204005	9.786248e-01	0.009
Cytosolic tRNA aminoacylation	R-HSA-379716	9.787163e-01	0.009
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	9.787163e-01	0.009
Synthesis of PA	R-HSA-1483166	9.795989e-01	0.009
FRS-mediated FGFR2 signaling	R-HSA-5654700	9.800908e-01	0.009
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.800908e-01	0.009
Prednisone ADME	R-HSA-9757110	9.800908e-01	0.009
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.800908e-01	0.009
Inflammasomes	R-HSA-622312	9.800908e-01	0.009
Ion channel transport	R-HSA-983712	9.801717e-01	0.009
Toll-like Receptor Cascades	R-HSA-168898	9.821883e-01	0.008
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.822593e-01	0.008
Thyroxine biosynthesis	R-HSA-209968	9.822593e-01	0.008
Interferon gamma signaling	R-HSA-877300	9.826535e-01	0.008
Asymmetric localization of PCP proteins	R-HSA-4608870	9.841740e-01	0.007
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.841740e-01	0.007
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.841917e-01	0.007
Neurotransmitter clearance	R-HSA-112311	9.841917e-01	0.007
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.841917e-01	0.007
G alpha (s) signalling events	R-HSA-418555	9.842919e-01	0.007
tRNA Aminoacylation	R-HSA-379724	9.843876e-01	0.007
Glutathione conjugation	R-HSA-156590	9.843876e-01	0.007
SARS-CoV Infections	R-HSA-9679506	9.851710e-01	0.006
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	9.852123e-01	0.006
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	9.852123e-01	0.006
Chaperonin-mediated protein folding	R-HSA-390466	9.855732e-01	0.006
Interleukin-12 family signaling	R-HSA-447115	9.855732e-01	0.006
Formation of paraxial mesoderm	R-HSA-9793380	9.857293e-01	0.006
Molecules associated with elastic fibres	R-HSA-2129379	9.859137e-01	0.006
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	9.859137e-01	0.006
DAG1 glycosylations	R-HSA-8931838	9.874482e-01	0.005
Inwardly rectifying K+ channels	R-HSA-1296065	9.874482e-01	0.005
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	9.879463e-01	0.005
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	9.879463e-01	0.005
Plasma lipoprotein remodeling	R-HSA-8963899	9.882608e-01	0.005
Metal ion SLC transporters	R-HSA-425410	9.882608e-01	0.005
rRNA processing	R-HSA-72312	9.889658e-01	0.005
Ion transport by P-type ATPases	R-HSA-936837	9.891223e-01	0.005
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.893787e-01	0.005
Acyl chain remodelling of PC	R-HSA-1482788	9.900342e-01	0.004
Cellular response to hypoxia	R-HSA-1234174	9.900696e-01	0.004
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.910303e-01	0.004
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.910303e-01	0.004
Gap junction assembly	R-HSA-190861	9.911200e-01	0.004
eNOS activation	R-HSA-203615	9.911200e-01	0.004
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	9.911200e-01	0.004
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.911200e-01	0.004
Phosphate bond hydrolysis by NUDT proteins	R-HSA-2393930	9.911200e-01	0.004
Activation of NF-kappaB in B cells	R-HSA-1169091	9.913115e-01	0.004
Hedgehog ligand biogenesis	R-HSA-5358346	9.913115e-01	0.004
Beta-catenin independent WNT signaling	R-HSA-3858494	9.913463e-01	0.004
Integration of energy metabolism	R-HSA-163685	9.913463e-01	0.004
RSV-host interactions	R-HSA-9833110	9.916262e-01	0.004
Nicotinate metabolism	R-HSA-196807	9.917312e-01	0.004
Platelet degranulation	R-HSA-114608	9.920574e-01	0.003
C-type lectin receptors (CLRs)	R-HSA-5621481	9.920718e-01	0.003
Acyl chain remodelling of PE	R-HSA-1482839	9.920876e-01	0.003
Transferrin endocytosis and recycling	R-HSA-917977	9.920876e-01	0.003
Potential therapeutics for SARS	R-HSA-9679191	9.928852e-01	0.003
HSF1 activation	R-HSA-3371511	9.929498e-01	0.003
Glycosphingolipid transport	R-HSA-9845576	9.929498e-01	0.003
Degradation of AXIN	R-HSA-4641257	9.937181e-01	0.003
NCAM1 interactions	R-HSA-419037	9.937181e-01	0.003
SLC-mediated transport of organic cations	R-HSA-549127	9.937181e-01	0.003
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.937181e-01	0.003
Metabolism of folate and pterines	R-HSA-196757	9.937181e-01	0.003
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.937304e-01	0.003
Interleukin-1 family signaling	R-HSA-446652	9.937704e-01	0.003
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.942861e-01	0.002
ECM proteoglycans	R-HSA-3000178	9.942861e-01	0.002
Metabolism of porphyrins	R-HSA-189445	9.942861e-01	0.002
Purine salvage	R-HSA-74217	9.944027e-01	0.002
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.944027e-01	0.002
Elastic fibre formation	R-HSA-1566948	9.944027e-01	0.002
Pentose phosphate pathway	R-HSA-71336	9.950128e-01	0.002
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.951816e-01	0.002
Dectin-2 family	R-HSA-5621480	9.952687e-01	0.002
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.955564e-01	0.002
rRNA processing in the mitochondrion	R-HSA-8868766	9.955564e-01	0.002
N-glycan antennae elongation in the medial/trans-Golgi	R-HSA-975576	9.955564e-01	0.002
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.955564e-01	0.002
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	9.960407e-01	0.002
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.960407e-01	0.002
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.960407e-01	0.002
Aflatoxin activation and detoxification	R-HSA-5423646	9.960407e-01	0.002
Citric acid cycle (TCA cycle)	R-HSA-71403	9.960679e-01	0.002
Peroxisomal protein import	R-HSA-9033241	9.961425e-01	0.002
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	9.964723e-01	0.002
Degradation of GLI2 by the proteasome	R-HSA-5610783	9.964723e-01	0.002
Degradation of CRY and PER proteins	R-HSA-9932298	9.964723e-01	0.002
Scavenging by Class A Receptors	R-HSA-3000480	9.964723e-01	0.002
Heme biosynthesis	R-HSA-189451	9.964723e-01	0.002
RAB geranylgeranylation	R-HSA-8873719	9.965179e-01	0.002
Signaling by Retinoic Acid	R-HSA-5362517	9.965179e-01	0.002
Adaptive Immune System	R-HSA-1280218	9.968521e-01	0.001
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.968569e-01	0.001
PCP/CE pathway	R-HSA-4086400	9.970366e-01	0.001
SLC-mediated transport of organic anions	R-HSA-9955298	9.970366e-01	0.001
Cholesterol biosynthesis	R-HSA-191273	9.970366e-01	0.001
Unfolded Protein Response (UPR)	R-HSA-381119	9.971150e-01	0.001
Mitochondrial protein import	R-HSA-1268020	9.971641e-01	0.001
Defensins	R-HSA-1461973	9.971995e-01	0.001
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.971995e-01	0.001
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.974876e-01	0.001
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	9.975049e-01	0.001
Proteasome assembly	R-HSA-9907900	9.975049e-01	0.001
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.975049e-01	0.001
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.975049e-01	0.001
Surfactant metabolism	R-HSA-5683826	9.975049e-01	0.001
Amyloid fiber formation	R-HSA-977225	9.977712e-01	0.001
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.977769e-01	0.001
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.977769e-01	0.001
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	9.977769e-01	0.001
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	9.977769e-01	0.001
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.980193e-01	0.001
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.980193e-01	0.001
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.980193e-01	0.001
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.980790e-01	0.001
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	9.982353e-01	0.001
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.982353e-01	0.001
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.982937e-01	0.001
TCR signaling	R-HSA-202403	9.982944e-01	0.001
Kidney development	R-HSA-9830369	9.983073e-01	0.001
Metabolism of steroid hormones	R-HSA-196071	9.983073e-01	0.001
O-linked glycosylation of mucins	R-HSA-913709	9.984740e-01	0.001
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.985992e-01	0.001
Chemokine receptors bind chemokines	R-HSA-380108	9.985992e-01	0.001
Azathioprine ADME	R-HSA-9748787	9.987520e-01	0.001
Hemostasis	R-HSA-109582	9.987730e-01	0.001
ABC-family proteins mediated transport	R-HSA-382556	9.987773e-01	0.001
Cargo trafficking to the periciliary membrane	R-HSA-5620920	9.988829e-01	0.000
Metabolism of cofactors	R-HSA-8978934	9.988829e-01	0.000
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.988881e-01	0.000
Complex IV assembly	R-HSA-9864848	9.988881e-01	0.000
The phototransduction cascade	R-HSA-2514856	9.988881e-01	0.000
Purine catabolism	R-HSA-74259	9.989935e-01	0.000
Uptake and actions of bacterial toxins	R-HSA-5339562	9.990094e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.990338e-01	0.000
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.990680e-01	0.000
G alpha (q) signalling events	R-HSA-416476	9.991043e-01	0.000
Nucleotide biosynthesis	R-HSA-8956320	9.991175e-01	0.000
Iron uptake and transport	R-HSA-917937	9.992644e-01	0.000
Platelet homeostasis	R-HSA-418346	9.993561e-01	0.000
Metabolism of amine-derived hormones	R-HSA-209776	9.993759e-01	0.000
Viral Infection Pathways	R-HSA-9824446	9.994285e-01	0.000
Disorders of transmembrane transporters	R-HSA-5619115	9.994343e-01	0.000
Interleukin-10 signaling	R-HSA-6783783	9.994629e-01	0.000
Integrin cell surface interactions	R-HSA-216083	9.994629e-01	0.000
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.995165e-01	0.000
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.996069e-01	0.000
FCERI mediated MAPK activation	R-HSA-2871796	9.996311e-01	0.000
Endogenous sterols	R-HSA-211976	9.996498e-01	0.000
Nucleotide salvage	R-HSA-8956321	9.996498e-01	0.000
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.996829e-01	0.000
Protein localization	R-HSA-9609507	9.996949e-01	0.000
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.997923e-01	0.000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.998250e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.998279e-01	0.000
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.998321e-01	0.000
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.998403e-01	0.000
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.998571e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.998619e-01	0.000
Downstream TCR signaling	R-HSA-202424	9.998642e-01	0.000
Retinoid metabolism and transport	R-HSA-975634	9.998898e-01	0.000
Formation of the cornified envelope	R-HSA-6809371	9.999018e-01	0.000
Diseases of carbohydrate metabolism	R-HSA-5663084	9.999125e-01	0.000
Aspirin ADME	R-HSA-9749641	9.999125e-01	0.000
Mitochondrial protein degradation	R-HSA-9837999	9.999203e-01	0.000
ROS and RNS production in phagocytes	R-HSA-1222556	9.999221e-01	0.000
Neutrophil degranulation	R-HSA-6798695	9.999272e-01	0.000
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.999284e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.999422e-01	0.000
ABC transporter disorders	R-HSA-5619084	9.999510e-01	0.000
Post-translational protein phosphorylation	R-HSA-8957275	9.999534e-01	0.000
Regulation of insulin secretion	R-HSA-422356	9.999534e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999569e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.999649e-01	0.000
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.999653e-01	0.000
Interleukin-1 signaling	R-HSA-9020702	9.999662e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.999755e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999766e-01	0.000
Leishmania phagocytosis	R-HSA-9664417	9.999844e-01	0.000
Parasite infection	R-HSA-9664407	9.999844e-01	0.000
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.999844e-01	0.000
Pyruvate metabolism	R-HSA-70268	9.999846e-01	0.000
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.999859e-01	0.000
Signaling by GPCR	R-HSA-372790	9.999873e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.999885e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.999891e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999897e-01	0.000
Neddylation	R-HSA-8951664	9.999903e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.999914e-01	0.000
FCGR activation	R-HSA-2029481	9.999931e-01	0.000
Sensory perception of taste	R-HSA-9717189	9.999932e-01	0.000
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.999933e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999955e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.999957e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.999966e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999967e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.999970e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999978e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999981e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999981e-01	0.000
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999985e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.999985e-01	0.000
FCERI mediated NF-kB activation	R-HSA-2871837	9.999986e-01	0.000
Extracellular matrix organization	R-HSA-1474244	9.999987e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.999990e-01	0.000
Antigen processing-Cross presentation	R-HSA-1236975	9.999990e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999991e-01	0.000
Asparagine N-linked glycosylation	R-HSA-446203	9.999995e-01	0.000
Translation	R-HSA-72766	9.999997e-01	0.000
Immune System	R-HSA-168256	9.999999e-01	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999999e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999999e-01	0.000
Regulation of Complement cascade	R-HSA-977606	9.999999e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999999e-01	0.000
Post-translational protein modification	R-HSA-597592	9.999999e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	1.000000e+00	0.000
Drug ADME	R-HSA-9748784	1.000000e+00	0.000
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000
Mitochondrial translation	R-HSA-5368287	1.000000e+00	0.000
Keratinization	R-HSA-6805567	1.000000e+00	0.000
Parasitic Infection Pathways	R-HSA-9824443	1.000000e+00	0.000
Leishmania infection	R-HSA-9658195	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Complement cascade	R-HSA-166658	1.000000e+00	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	1.000000e+00	0.000
Leishmania parasite growth and survival	R-HSA-9664433	1.000000e+00	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	1.000000e+00	0.000
Respiratory electron transport	R-HSA-611105	1.000000e+00	0.000
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000
G alpha (i) signalling events	R-HSA-418594	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000
Sphingolipid metabolism	R-HSA-428157	1.000000e+00	0.000
Innate Immune System	R-HSA-168249	1.000000e+00	0.000
Disease	R-HSA-1643685	1.000000e+00	0.000
Infectious disease	R-HSA-5663205	1.000000e+00	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	5.312082e-09	8.275
Metabolism of RNA	R-HSA-8953854	5.437025e-08	7.265
mRNA 3'-end processing	R-HSA-72187	1.249053e-06	5.903
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	2.118990e-06	5.674
mRNA Splicing - Major Pathway	R-HSA-72163	2.202671e-06	5.657
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	2.715595e-06	5.566
RNA Polymerase II Transcription Termination	R-HSA-73856	2.782795e-06	5.556
mRNA Splicing	R-HSA-72172	3.339015e-06	5.476
HSF1-dependent transactivation	R-HSA-3371571	3.706288e-06	5.431
MITF-M-dependent gene expression	R-HSA-9856651	4.040639e-06	5.394
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	5.313405e-06	5.275
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	4.926324e-06	5.307
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	5.184605e-06	5.285
Cellular response to heat stress	R-HSA-3371556	4.896659e-06	5.310
SWI/SNF chromatin remodelers	R-HSA-9932451	8.428071e-06	5.074
ATP-dependent chromatin remodelers	R-HSA-9932444	8.428071e-06	5.074
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	1.030363e-05	4.987
Attenuation phase	R-HSA-3371568	1.080570e-05	4.966
Apoptotic execution phase	R-HSA-75153	1.562746e-05	4.806
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.979080e-05	4.704
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	2.923146e-05	4.534
MITF-M-regulated melanocyte development	R-HSA-9730414	3.906572e-05	4.408
Cell Cycle	R-HSA-1640170	4.959947e-05	4.305
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	5.404008e-05	4.267
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	5.404008e-05	4.267
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	6.911071e-05	4.160
Cell Cycle, Mitotic	R-HSA-69278	8.229187e-05	4.085
HSF1 activation	R-HSA-3371511	2.205025e-04	3.657
Chromatin organization	R-HSA-4839726	2.184166e-04	3.661
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	2.307920e-04	3.637
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	3.245532e-04	3.489
Apoptosis	R-HSA-109581	3.873376e-04	3.412
Transcriptional regulation by RUNX1	R-HSA-8878171	4.607084e-04	3.337
Apoptotic cleavage of cellular proteins	R-HSA-111465	9.234253e-04	3.035
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	1.105699e-03	2.956
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	1.105699e-03	2.956
Programmed Cell Death	R-HSA-5357801	1.131152e-03	2.946
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	1.473281e-03	2.832
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.567426e-03	2.805
Epigenetic regulation of gene expression	R-HSA-212165	1.798483e-03	2.745
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	2.191156e-03	2.659
rRNA modification in the nucleus and cytosol	R-HSA-6790901	2.777666e-03	2.556
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	2.968580e-03	2.527
Nuclear Envelope Breakdown	R-HSA-2980766	3.190482e-03	2.496
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	3.641005e-03	2.439
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	3.576002e-03	2.447
G-protein beta:gamma signalling	R-HSA-397795	3.647177e-03	2.438
XBP1(S) activates chaperone genes	R-HSA-381038	3.526980e-03	2.453
AKT phosphorylates targets in the cytosol	R-HSA-198323	3.876753e-03	2.412
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	3.965326e-03	2.402
M Phase	R-HSA-68886	4.028241e-03	2.395
Chromatin modifying enzymes	R-HSA-3247509	4.513571e-03	2.345
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	4.636452e-03	2.334
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	6.153965e-03	2.211
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	6.153965e-03	2.211
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	6.153965e-03	2.211
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	6.153965e-03	2.211
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	6.153965e-03	2.211
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	6.153965e-03	2.211
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	6.153965e-03	2.211
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	6.153965e-03	2.211
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	6.153965e-03	2.211
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	6.153965e-03	2.211
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	6.153965e-03	2.211
ALK mutants bind TKIs	R-HSA-9700645	5.291942e-03	2.276
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	5.554404e-03	2.255
rRNA processing in the nucleus and cytosol	R-HSA-8868773	6.056383e-03	2.218
Mitotic G1 phase and G1/S transition	R-HSA-453279	5.699251e-03	2.244
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	5.117481e-03	2.291
PKMTs methylate histone lysines	R-HSA-3214841	5.394653e-03	2.268
IRE1alpha activates chaperones	R-HSA-381070	6.467440e-03	2.189
S Phase	R-HSA-69242	6.603427e-03	2.180
Mitotic Anaphase	R-HSA-68882	7.337721e-03	2.134
Cellular responses to stress	R-HSA-2262752	7.103408e-03	2.149
Apoptosis induced DNA fragmentation	R-HSA-140342	7.336729e-03	2.134
Mitotic Metaphase and Anaphase	R-HSA-2555396	7.784399e-03	2.109
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	7.859985e-03	2.105
Signaling by ALK in cancer	R-HSA-9700206	7.859985e-03	2.105
Regulation of CDH1 Function	R-HSA-9764561	7.892377e-03	2.103
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	7.825769e-03	2.106
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	8.552988e-03	2.068
Cap-dependent Translation Initiation	R-HSA-72737	9.940326e-03	2.003
Eukaryotic Translation Initiation	R-HSA-72613	9.940326e-03	2.003
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.980195e-03	2.001
Cell Cycle Checkpoints	R-HSA-69620	1.057641e-02	1.976
Transcriptional Regulation by E2F6	R-HSA-8953750	1.090387e-02	1.962
Inhibition of nitric oxide production	R-HSA-9636249	1.124277e-02	1.949
G1/S Transition	R-HSA-69206	1.133651e-02	1.946
Interactions of Rev with host cellular proteins	R-HSA-177243	1.249301e-02	1.903
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	1.205775e-02	1.919
Regulation of CDH1 Expression and Function	R-HSA-9764265	1.205775e-02	1.919
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	1.306368e-02	1.884
Processing of Intronless Pre-mRNAs	R-HSA-77595	1.360611e-02	1.866
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	1.360611e-02	1.866
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.362776e-02	1.866
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.423667e-02	1.847
Nuclear import of Rev protein	R-HSA-180746	1.441051e-02	1.841
Signaling by RAF1 mutants	R-HSA-9656223	1.618628e-02	1.791
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	1.646060e-02	1.784
Inhibition of TSC complex formation by PKB	R-HSA-165181	1.817811e-02	1.740
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	1.735783e-02	1.761
AKT-mediated inactivation of FOXO1A	R-HSA-211163	1.817811e-02	1.740
Host Interactions of HIV factors	R-HSA-162909	1.796181e-02	1.746
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.753351e-02	1.756
Cellular Senescence	R-HSA-2559583	1.827872e-02	1.738
MTOR signalling	R-HSA-165159	1.831042e-02	1.737
G beta:gamma signalling through PLC beta	R-HSA-418217	2.022800e-02	1.694
Switching of origins to a post-replicative state	R-HSA-69052	1.895041e-02	1.722
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	1.892681e-02	1.723
Downregulation of ERBB2 signaling	R-HSA-8863795	1.909049e-02	1.719
Presynaptic function of Kainate receptors	R-HSA-500657	2.022800e-02	1.694
Depolymerization of the Nuclear Lamina	R-HSA-4419969	2.022800e-02	1.694
Unfolded Protein Response (UPR)	R-HSA-381119	1.905734e-02	1.720
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	2.023920e-02	1.694
Vpr-mediated nuclear import of PICs	R-HSA-180910	2.153405e-02	1.667
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	2.153405e-02	1.667
HIV Infection	R-HSA-162906	2.163233e-02	1.665
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	2.174366e-02	1.663
Orc1 removal from chromatin	R-HSA-68949	2.416523e-02	1.617
Membrane Trafficking	R-HSA-199991	2.421794e-02	1.616
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	2.438954e-02	1.613
Signaling by NOTCH1	R-HSA-1980143	2.476000e-02	1.606
Sema4D in semaphorin signaling	R-HSA-400685	2.535892e-02	1.596
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	2.875359e-02	1.541
Transport of the SLBP independent Mature mRNA	R-HSA-159227	2.876279e-02	1.541
Golgi Associated Vesicle Biogenesis	R-HSA-432722	2.678173e-02	1.572
Synthesis of DNA	R-HSA-69239	2.824362e-02	1.549
Oncogenic MAPK signaling	R-HSA-6802957	2.652850e-02	1.576
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	2.876279e-02	1.541
NS1 Mediated Effects on Host Pathways	R-HSA-168276	2.750430e-02	1.561
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	2.677763e-02	1.572
Cellular responses to stimuli	R-HSA-8953897	2.885188e-02	1.540
mRNA Splicing - Minor Pathway	R-HSA-72165	2.888148e-02	1.539
Signaling downstream of RAS mutants	R-HSA-9649948	2.888148e-02	1.539
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	2.888148e-02	1.539
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	2.888148e-02	1.539
Signaling by RAS mutants	R-HSA-6802949	2.888148e-02	1.539
Translation initiation complex formation	R-HSA-72649	2.959666e-02	1.529
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	2.982536e-02	1.525
DNA Damage Recognition in GG-NER	R-HSA-5696394	3.262469e-02	1.486
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	3.262469e-02	1.486
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	3.161119e-02	1.500
Breakdown of the nuclear lamina	R-HSA-352238	3.121655e-02	1.506
Interactions of Vpr with host cellular proteins	R-HSA-176033	3.088873e-02	1.510
Adherens junctions interactions	R-HSA-418990	3.378331e-02	1.471
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	3.378622e-02	1.471
Nervous system development	R-HSA-9675108	3.487082e-02	1.458
Gene expression (Transcription)	R-HSA-74160	3.523395e-02	1.453
Ribosomal scanning and start codon recognition	R-HSA-72702	3.584962e-02	1.446
Axon guidance	R-HSA-422475	3.729406e-02	1.428
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	3.776313e-02	1.423
Signaling by ROBO receptors	R-HSA-376176	3.779926e-02	1.423
MAP2K and MAPK activation	R-HSA-5674135	3.850491e-02	1.414
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	3.930067e-02	1.406
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	3.935568e-02	1.405
G2/M Checkpoints	R-HSA-69481	4.049023e-02	1.393
Regulation of localization of FOXO transcription factors	R-HSA-9614399	4.069300e-02	1.390
Signaling by NOTCH4	R-HSA-9013694	4.135640e-02	1.383
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	4.137517e-02	1.383
mTORC1-mediated signalling	R-HSA-166208	4.547548e-02	1.342
Disorders of Developmental Biology	R-HSA-9675151	4.515009e-02	1.345
G1/S-Specific Transcription	R-HSA-69205	4.628300e-02	1.335
Activation of the pre-replicative complex	R-HSA-68962	4.957710e-02	1.305
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	4.957710e-02	1.305
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	4.976428e-02	1.303
Mitotic Telophase/Cytokinesis	R-HSA-68884	5.003986e-02	1.301
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	5.102147e-02	1.292
Kinesins	R-HSA-983189	5.102147e-02	1.292
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	5.102147e-02	1.292
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	5.215565e-02	1.283
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	5.215565e-02	1.283
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	5.215565e-02	1.283
Regulation of TP53 Expression	R-HSA-6804754	5.231357e-02	1.281
RUNX3 regulates p14-ARF	R-HSA-8951936	6.046341e-02	1.219
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	6.046341e-02	1.219
Thromboxane signalling through TP receptor	R-HSA-428930	5.940271e-02	1.226
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	5.573052e-02	1.254
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	5.573052e-02	1.254
Assembly of the pre-replicative complex	R-HSA-68867	5.491112e-02	1.260
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	5.303500e-02	1.275
Cyclin E associated events during G1/S transition	R-HSA-69202	5.805703e-02	1.236
Mitotic Prometaphase	R-HSA-68877	5.585588e-02	1.253
RUNX3 regulates NOTCH signaling	R-HSA-8941856	6.046341e-02	1.219
G alpha (12/13) signalling events	R-HSA-416482	5.591093e-02	1.253
HIV Life Cycle	R-HSA-162587	5.581109e-02	1.253
TCF dependent signaling in response to WNT	R-HSA-201681	5.409113e-02	1.267
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	6.046341e-02	1.219
Signaling by Hippo	R-HSA-2028269	5.303500e-02	1.275
Mismatch Repair	R-HSA-5358508	6.166971e-02	1.210
rRNA processing	R-HSA-72312	6.177427e-02	1.209
Hedgehog 'on' state	R-HSA-5632684	6.253004e-02	1.204
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	6.284955e-02	1.202
PKR-mediated signaling	R-HSA-9833482	6.434918e-02	1.191
RUNX3 regulates WNT signaling	R-HSA-8951430	6.472927e-02	1.189
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	6.472927e-02	1.189
Signaling by FGFR1 amplification mutants	R-HSA-1839120	7.708937e-02	1.113
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	7.708937e-02	1.113
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	7.708937e-02	1.113
IPs transport between nucleus and cytosol	R-HSA-1855170	6.940331e-02	1.159
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	7.641273e-02	1.117
Formation of a pool of free 40S subunits	R-HSA-72689	6.644991e-02	1.178
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	7.517762e-02	1.124
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	7.560618e-02	1.121
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	6.644991e-02	1.178
Nuclear RNA decay	R-HSA-9930044	6.940331e-02	1.159
Regulation of MECP2 expression and activity	R-HSA-9022692	6.940331e-02	1.159
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	7.708937e-02	1.113
Deubiquitination	R-HSA-5688426	7.173862e-02	1.144
Transcriptional regulation by RUNX3	R-HSA-8878159	7.498350e-02	1.125
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	6.722474e-02	1.172
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	7.692709e-02	1.114
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	6.722474e-02	1.172
Transcriptional regulation by RUNX2	R-HSA-8878166	6.705580e-02	1.174
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	7.260057e-02	1.139
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	8.075327e-02	1.093
Formation of annular gap junctions	R-HSA-196025	8.075327e-02	1.093
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	8.075327e-02	1.093
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	8.075327e-02	1.093
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	8.130172e-02	1.090
ISG15 antiviral mechanism	R-HSA-1169408	8.266060e-02	1.083
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	8.365258e-02	1.078
PTEN Regulation	R-HSA-6807070	8.488626e-02	1.071
Loss of Function of TP53 in Cancer	R-HSA-9723907	8.713381e-02	1.060
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	8.713381e-02	1.060
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	8.713381e-02	1.060
UCH proteinases	R-HSA-5689603	8.826130e-02	1.054
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	1.047436e-01	0.980
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	1.047436e-01	0.980
AKT phosphorylates targets in the nucleus	R-HSA-198693	9.830218e-02	1.007
Gap junction degradation	R-HSA-190873	9.830218e-02	1.007
G beta:gamma signalling through BTK	R-HSA-8964315	9.793496e-02	1.009
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	1.035571e-01	0.985
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	9.454203e-02	1.024
Amplification of signal from the kinetochores	R-HSA-141424	9.454203e-02	1.024
Regulation of endogenous retroelements	R-HSA-9842860	9.934568e-02	1.003
DNA Replication Pre-Initiation	R-HSA-69002	9.344567e-02	1.029
EPH-Ephrin signaling	R-HSA-2682334	8.922847e-02	1.049
Regulation of gene expression in beta cells	R-HSA-210745	1.041287e-01	0.982
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	9.111670e-02	1.040
Signaling by ERBB2	R-HSA-1227986	9.786212e-02	1.009
Mitotic Spindle Checkpoint	R-HSA-69618	8.907710e-02	1.050
Regulation of beta-cell development	R-HSA-186712	9.111670e-02	1.040
Activation of BAD and translocation to mitochondria	R-HSA-111447	9.793496e-02	1.009
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	9.830218e-02	1.007
Unwinding of DNA	R-HSA-176974	9.830218e-02	1.007
TBC/RABGAPs	R-HSA-8854214	9.906041e-02	1.004
Early Phase of HIV Life Cycle	R-HSA-162594	9.201189e-02	1.036
Regulation of PTEN gene transcription	R-HSA-8943724	9.786212e-02	1.009
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	9.793496e-02	1.009
Cellular response to mitochondrial stress	R-HSA-9840373	9.830218e-02	1.007
Cell-extracellular matrix interactions	R-HSA-446353	9.793496e-02	1.009
Sensory processing of sound	R-HSA-9659379	1.064363e-01	0.973
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.406925e-02	1.027
Clathrin-mediated endocytosis	R-HSA-8856828	1.064611e-01	0.973
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.073658e-01	0.969
Transcriptional Regulation by TP53	R-HSA-3700989	1.077364e-01	0.968
Smooth Muscle Contraction	R-HSA-445355	1.104840e-01	0.957
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.666800e-01	0.778
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.666800e-01	0.778
Diseases of Telomere Maintenance	R-HSA-9673013	1.666800e-01	0.778
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.666800e-01	0.778
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	1.666800e-01	0.778
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.666800e-01	0.778
TICAM1 deficiency - HSE	R-HSA-5602566	1.666800e-01	0.778
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	1.666800e-01	0.778
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	1.666800e-01	0.778
Hereditary fructose intolerance	R-HSA-5657560	1.666800e-01	0.778
NFG and proNGF binds to p75NTR	R-HSA-205017	2.392990e-01	0.621
TRAF3 deficiency - HSE	R-HSA-5602571	2.392990e-01	0.621
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.392990e-01	0.621
Defective VWF binding to collagen type I	R-HSA-9845622	2.392990e-01	0.621
Defective MMADHC causes MMAHCD	R-HSA-3359473	2.392990e-01	0.621
IRS activation	R-HSA-74713	1.345872e-01	0.871
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	1.345872e-01	0.871
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	1.345872e-01	0.871
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	1.660293e-01	0.780
PTK6 Regulates Cell Cycle	R-HSA-8849470	1.660293e-01	0.780
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.055936e-01	0.515
Enhanced cleavage of VWF variant by ADAMTS13	R-HSA-9845619	3.055936e-01	0.515
Defective DHDDS causes RP59	R-HSA-4755609	3.055936e-01	0.515
Defective VWF cleavage by ADAMTS13 variant	R-HSA-9845621	3.055936e-01	0.515
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	1.172316e-01	0.931
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	1.985654e-01	0.702
PTK6 Expression	R-HSA-8849473	2.317663e-01	0.635
TRIF-mediated programmed cell death	R-HSA-2562578	2.317663e-01	0.635
Cohesin Loading onto Chromatin	R-HSA-2470946	2.317663e-01	0.635
SOS-mediated signalling	R-HSA-112412	2.317663e-01	0.635
Recycling of eIF2:GDP	R-HSA-72731	2.317663e-01	0.635
Defective MMACHC causes MAHCC	R-HSA-3359474	3.661142e-01	0.436
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	3.661142e-01	0.436
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	3.661142e-01	0.436
Axonal growth stimulation	R-HSA-209563	3.661142e-01	0.436
Signaling by plasma membrane FGFR1 fusions	R-HSA-8853336	3.661142e-01	0.436
Invadopodia formation	R-HSA-8941237	3.661142e-01	0.436
Defective SLC7A7 causes lysinuric protein intolerance (LPI)	R-HSA-5660862	3.661142e-01	0.436
Adrenaline signalling through Alpha-2 adrenergic receptor	R-HSA-392023	3.661142e-01	0.436
MET activates PTPN11	R-HSA-8865999	3.661142e-01	0.436
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	1.276524e-01	0.894
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.807708e-01	0.743
Repression of WNT target genes	R-HSA-4641265	1.807708e-01	0.743
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	1.157814e-01	0.936
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	2.036863e-01	0.691
Signaling by ERBB2 ECD mutants	R-HSA-9665348	1.606218e-01	0.794
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	1.606218e-01	0.794
Lipophagy	R-HSA-9613354	2.987705e-01	0.525
Inactivation of CDC42 and RAC1	R-HSA-428543	2.987705e-01	0.525
NADE modulates death signalling	R-HSA-205025	4.213635e-01	0.375
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine	R-HSA-9735763	4.213635e-01	0.375
PLCG1 events in ERBB2 signaling	R-HSA-1251932	4.213635e-01	0.375
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	4.213635e-01	0.375
Nucleotide catabolism defects	R-HSA-9735786	4.213635e-01	0.375
GRB7 events in ERBB2 signaling	R-HSA-1306955	4.213635e-01	0.375
Signaling by MAP2K mutants	R-HSA-9652169	4.213635e-01	0.375
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	4.213635e-01	0.375
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.962999e-01	0.707
G0 and Early G1	R-HSA-1538133	1.374550e-01	0.862
Processive synthesis on the lagging strand	R-HSA-69183	2.512314e-01	0.600
MET activates RAP1 and RAC1	R-HSA-8875555	3.320154e-01	0.479
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	3.320154e-01	0.479
2-LTR circle formation	R-HSA-164843	3.320154e-01	0.479
EPHA-mediated growth cone collapse	R-HSA-3928663	1.859759e-01	0.731
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	2.341104e-01	0.631
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	1.750985e-01	0.757
Degradation of GLI1 by the proteasome	R-HSA-5610780	1.644478e-01	0.784
Signaling by APC mutants	R-HSA-4839744	3.647947e-01	0.438
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	3.647947e-01	0.438
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	3.647947e-01	0.438
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	3.647947e-01	0.438
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	4.718002e-01	0.326
FGFR1c and Klotho ligand binding and activation	R-HSA-190374	4.718002e-01	0.326
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	4.718002e-01	0.326
Defective F9 activation	R-HSA-9673221	4.718002e-01	0.326
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	4.718002e-01	0.326
snRNP Assembly	R-HSA-191859	1.636830e-01	0.786
Metabolism of non-coding RNA	R-HSA-194441	1.636830e-01	0.786
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	3.969371e-01	0.401
Signaling by activated point mutants of FGFR1	R-HSA-1839122	3.969371e-01	0.401
Condensation of Prometaphase Chromosomes	R-HSA-2514853	3.969371e-01	0.401
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	3.969371e-01	0.401
Signaling by GSK3beta mutants	R-HSA-5339716	3.969371e-01	0.401
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	1.977579e-01	0.704
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	2.456085e-01	0.610
Ephrin signaling	R-HSA-3928664	3.495102e-01	0.457
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	3.495102e-01	0.457
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	2.263582e-01	0.645
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	2.396148e-01	0.620
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	2.211723e-01	0.655
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	2.332478e-01	0.632
Striated Muscle Contraction	R-HSA-390522	3.023957e-01	0.519
Impaired BRCA2 binding to PALB2	R-HSA-9709603	3.740817e-01	0.427
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	4.283047e-01	0.368
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	4.283047e-01	0.368
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	4.283047e-01	0.368
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	4.283047e-01	0.368
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	4.283047e-01	0.368
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	4.283047e-01	0.368
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	5.178434e-01	0.286
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	5.178434e-01	0.286
Noncanonical activation of NOTCH3	R-HSA-9017802	5.178434e-01	0.286
Defective CSF2RB causes SMDP5	R-HSA-5688849	5.178434e-01	0.286
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	5.178434e-01	0.286
Defective CSF2RA causes SMDP4	R-HSA-5688890	5.178434e-01	0.286
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	2.913033e-01	0.536
Interaction between L1 and Ankyrins	R-HSA-445095	3.546482e-01	0.450
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	3.984633e-01	0.400
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	3.984633e-01	0.400
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	3.984633e-01	0.400
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	3.984633e-01	0.400
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	2.169999e-01	0.664
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	4.587886e-01	0.338
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	3.090685e-01	0.510
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	4.225759e-01	0.374
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	3.234340e-01	0.490
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	3.234340e-01	0.490
Signaling by ERBB2 KD Mutants	R-HSA-9664565	3.954577e-01	0.403
Late endosomal microautophagy	R-HSA-9615710	3.954577e-01	0.403
Nucleosome assembly	R-HSA-774815	3.544784e-01	0.450
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	3.544784e-01	0.450
Nonsense-Mediated Decay (NMD)	R-HSA-927802	2.469847e-01	0.607
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	2.469847e-01	0.607
Signaling by ERBB2 in Cancer	R-HSA-1227990	4.157238e-01	0.381
Removal of the Flap Intermediate	R-HSA-69166	4.883045e-01	0.311
Erythropoietin activates STAT5	R-HSA-9027283	5.598755e-01	0.252
Autointegration results in viral DNA circles	R-HSA-177539	5.598755e-01	0.252
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	3.075586e-01	0.512
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	3.670720e-01	0.435
PI-3K cascade:FGFR1	R-HSA-5654689	4.697208e-01	0.328
FGFR2 alternative splicing	R-HSA-6803529	4.697208e-01	0.328
Notch-HLH transcription pathway	R-HSA-350054	4.697208e-01	0.328
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	4.557416e-01	0.341
Erythropoietin activates RAS	R-HSA-9027284	5.167897e-01	0.287
Beta-catenin phosphorylation cascade	R-HSA-196299	5.167897e-01	0.287
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	5.167897e-01	0.287
RNA Polymerase III Chain Elongation	R-HSA-73780	5.167897e-01	0.287
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	3.634216e-01	0.440
Interleukin receptor SHC signaling	R-HSA-912526	4.926368e-01	0.307
Assembly of the ORC complex at the origin of replication	R-HSA-68616	4.754092e-01	0.323
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	4.025757e-01	0.395
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	5.150506e-01	0.288
Deadenylation of mRNA	R-HSA-429947	5.150506e-01	0.288
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	5.441994e-01	0.264
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	5.441994e-01	0.264
Phosphorylation of the APC/C	R-HSA-176412	5.441994e-01	0.264
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	5.441994e-01	0.264
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	4.584826e-01	0.339
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	4.693189e-01	0.329
Loss of Nlp from mitotic centrosomes	R-HSA-380259	4.693189e-01	0.329
Dual Incision in GG-NER	R-HSA-5696400	5.138796e-01	0.289
Polymerase switching on the C-strand of the telomere	R-HSA-174411	5.369228e-01	0.270
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	5.369228e-01	0.270
Activation of G protein gated Potassium channels	R-HSA-1296041	5.369228e-01	0.270
G protein gated Potassium channels	R-HSA-1296059	5.369228e-01	0.270
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	5.369228e-01	0.270
Viral mRNA Translation	R-HSA-192823	4.661277e-01	0.331
Centrosome maturation	R-HSA-380287	4.852995e-01	0.314
HDACs deacetylate histones	R-HSA-3214815	5.124993e-01	0.290
AURKA Activation by TPX2	R-HSA-8854518	5.120748e-01	0.291
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	5.582204e-01	0.253
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	5.509944e-01	0.259
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	5.238064e-01	0.281
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	5.398970e-01	0.268
Neutrophil degranulation	R-HSA-6798695	5.564021e-01	0.255
Signaling by FGFR1 in disease	R-HSA-5655302	1.644478e-01	0.784
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	3.678255e-01	0.434
FGFR1 mutant receptor activation	R-HSA-1839124	1.495525e-01	0.825
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	3.495102e-01	0.457
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	1.172316e-01	0.931
Degradation of beta-catenin by the destruction complex	R-HSA-195253	1.804271e-01	0.744
PI3K/AKT Signaling in Cancer	R-HSA-2219528	5.427179e-01	0.265
Ribosome-associated quality control	R-HSA-9948299	1.811967e-01	0.742
Platelet Aggregation (Plug Formation)	R-HSA-76009	3.544784e-01	0.450
EPHB-mediated forward signaling	R-HSA-3928662	2.006572e-01	0.698
RNA Polymerase III Transcription	R-HSA-74158	5.509944e-01	0.259
p75NTR regulates axonogenesis	R-HSA-193697	2.987705e-01	0.525
TGFBR3 expression	R-HSA-9839394	1.562263e-01	0.806
Nucleotide Excision Repair	R-HSA-5696398	1.880317e-01	0.726
Circadian clock	R-HSA-9909396	3.756565e-01	0.425
Integration of provirus	R-HSA-162592	1.586212e-01	0.800
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	1.157814e-01	0.936
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	2.006572e-01	0.698
Asymmetric localization of PCP proteins	R-HSA-4608870	2.133652e-01	0.671
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	2.973211e-01	0.527
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	4.883045e-01	0.311
Axonal growth inhibition (RHOA activation)	R-HSA-193634	2.652695e-01	0.576
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	2.987705e-01	0.525
G beta:gamma signalling through CDC42	R-HSA-8964616	3.001605e-01	0.523
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	3.342107e-01	0.476
IRS-related events triggered by IGF1R	R-HSA-2428928	2.966351e-01	0.528
G-protein activation	R-HSA-202040	4.225759e-01	0.374
Meiotic synapsis	R-HSA-1221632	3.234340e-01	0.490
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	4.852995e-01	0.314
G1 Phase	R-HSA-69236	5.130748e-01	0.290
Cyclin D associated events in G1	R-HSA-69231	5.130748e-01	0.290
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	5.138796e-01	0.289
Co-inhibition by CTLA4	R-HSA-389513	1.962999e-01	0.707
Diseases of mitotic cell cycle	R-HSA-9675126	1.374550e-01	0.862
PI3K/AKT activation	R-HSA-198203	3.320154e-01	0.479
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	2.536336e-01	0.596
Deadenylation-dependent mRNA decay	R-HSA-429914	1.636830e-01	0.786
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	1.473794e-01	0.832
VxPx cargo-targeting to cilium	R-HSA-5620916	3.984633e-01	0.400
Peptide chain elongation	R-HSA-156902	2.751373e-01	0.560
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	4.660467e-01	0.332
Cellular response to hypoxia	R-HSA-1234174	4.979447e-01	0.303
Chaperone Mediated Autophagy	R-HSA-9613829	1.606218e-01	0.794
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	3.498996e-01	0.456
GP1b-IX-V activation signalling	R-HSA-430116	2.987705e-01	0.525
IRS-mediated signalling	R-HSA-112399	5.426022e-01	0.266
RNA Polymerase III Transcription Initiation	R-HSA-76046	4.157238e-01	0.381
IGF1R signaling cascade	R-HSA-2428924	3.364419e-01	0.473
Regulation of gap junction activity	R-HSA-191650	4.213635e-01	0.375
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	4.718002e-01	0.326
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	2.093370e-01	0.679
Separation of Sister Chromatids	R-HSA-2467813	1.155147e-01	0.937
Platelet Adhesion to exposed collagen	R-HSA-75892	4.587886e-01	0.338
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	4.225759e-01	0.374
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	2.858194e-01	0.544
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	4.463491e-01	0.350
Regulation of mitotic cell cycle	R-HSA-453276	4.314128e-01	0.365
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	4.314128e-01	0.365
RAF activation	R-HSA-5673000	5.138796e-01	0.289
Signal amplification	R-HSA-392518	1.750985e-01	0.757
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	2.536336e-01	0.596
Chaperonin-mediated protein folding	R-HSA-390466	1.729679e-01	0.762
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	3.342107e-01	0.476
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	2.237918e-01	0.650
DNA Double Strand Break Response	R-HSA-5693606	1.529020e-01	0.816
Lagging Strand Synthesis	R-HSA-69186	4.225759e-01	0.374
Proteasome assembly	R-HSA-9907900	5.130748e-01	0.290
Regulation of TP53 Activity	R-HSA-5633007	1.436462e-01	0.843
Hedgehog 'off' state	R-HSA-5610787	4.319095e-01	0.365
Degradation of DVL	R-HSA-4641258	2.164068e-01	0.665
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	4.442848e-01	0.352
RNA Polymerase II Pre-transcription Events	R-HSA-674695	4.719297e-01	0.326
DNA Replication	R-HSA-69306	1.589799e-01	0.799
DNA strand elongation	R-HSA-69190	1.374550e-01	0.862
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	4.718002e-01	0.326
Post-transcriptional silencing by small RNAs	R-HSA-426496	4.718002e-01	0.326
Activation of AKT2	R-HSA-165158	4.718002e-01	0.326
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	2.339663e-01	0.631
HATs acetylate histones	R-HSA-3214847	1.368320e-01	0.864
Hh mutants are degraded by ERAD	R-HSA-5362768	2.758603e-01	0.559
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	4.283047e-01	0.368
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	2.100430e-01	0.678
Eukaryotic Translation Elongation	R-HSA-156842	2.263302e-01	0.645
Late Phase of HIV Life Cycle	R-HSA-162599	2.161306e-01	0.665
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	3.591405e-01	0.445
VEGFR2 mediated vascular permeability	R-HSA-5218920	4.442848e-01	0.352
PI3K Cascade	R-HSA-109704	4.344350e-01	0.362
Regulation of necroptotic cell death	R-HSA-5675482	4.754092e-01	0.323
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	4.502912e-01	0.347
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	4.790618e-01	0.320
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	5.138796e-01	0.289
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	4.584826e-01	0.339
DNA Double-Strand Break Repair	R-HSA-5693532	3.021430e-01	0.520
PIP3 activates AKT signaling	R-HSA-1257604	3.583769e-01	0.446
Regulation of TNFR1 signaling	R-HSA-5357905	5.461355e-01	0.263
Oncogene Induced Senescence	R-HSA-2559585	5.326199e-01	0.274
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	4.947995e-01	0.306
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	2.755865e-01	0.560
Nectin/Necl trans heterodimerization	R-HSA-420597	4.718002e-01	0.326
Developmental Lineages of the Mammary Gland	R-HSA-9924644	3.095986e-01	0.509
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	4.157238e-01	0.381
Lysosome Vesicle Biogenesis	R-HSA-432720	5.509944e-01	0.259
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	4.257089e-01	0.371
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	4.257089e-01	0.371
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	4.257089e-01	0.371
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	4.257089e-01	0.371
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	2.557598e-01	0.592
Intracellular signaling by second messengers	R-HSA-9006925	3.218700e-01	0.492
Calmodulin induced events	R-HSA-111933	5.509944e-01	0.259
Regulation of CDH19 Expression and Function	R-HSA-9764302	1.660293e-01	0.780
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	1.807708e-01	0.743
Pervasive developmental disorders	R-HSA-9005895	1.807708e-01	0.743
Disorders of Nervous System Development	R-HSA-9697154	1.807708e-01	0.743
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	4.213635e-01	0.375
Transcriptional activation of p53 responsive genes	R-HSA-69560	4.213635e-01	0.375
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	4.213635e-01	0.375
Activation of C3 and C5	R-HSA-174577	4.718002e-01	0.326
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	4.718002e-01	0.326
Regulation of RAS by GAPs	R-HSA-5658442	1.647092e-01	0.783
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	3.740817e-01	0.427
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	5.598755e-01	0.252
Eukaryotic Translation Termination	R-HSA-72764	3.747766e-01	0.426
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	4.025125e-01	0.395
Estrogen-dependent gene expression	R-HSA-9018519	4.240206e-01	0.373
CaM pathway	R-HSA-111997	5.509944e-01	0.259
trans-Golgi Network Vesicle Budding	R-HSA-199992	1.200818e-01	0.921
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	1.345872e-01	0.871
Neurofascin interactions	R-HSA-447043	1.985654e-01	0.702
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	1.708485e-01	0.767
Protein folding	R-HSA-391251	1.463388e-01	0.835
NRAGE signals death through JNK	R-HSA-193648	2.332478e-01	0.632
Hh mutants abrogate ligand secretion	R-HSA-5387390	3.226703e-01	0.491
NoRC negatively regulates rRNA expression	R-HSA-427413	4.314128e-01	0.365
Signaling by Hedgehog	R-HSA-5358351	4.434355e-01	0.353
Signaling by WNT	R-HSA-195721	1.507831e-01	0.822
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	5.441994e-01	0.264
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	5.120748e-01	0.291
Oxidative Stress Induced Senescence	R-HSA-2559580	2.372388e-01	0.625
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	1.175691e-01	0.930
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	4.754092e-01	0.323
Transcriptional Regulation by VENTX	R-HSA-8853884	1.530799e-01	0.815
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	2.531129e-01	0.597
DAG and IP3 signaling	R-HSA-1489509	5.297347e-01	0.276
PLC beta mediated events	R-HSA-112043	4.403121e-01	0.356
Mitotic Prophase	R-HSA-68875	1.125118e-01	0.949
Beta-catenin independent WNT signaling	R-HSA-3858494	3.250051e-01	0.488
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	5.441994e-01	0.264
ESR-mediated signaling	R-HSA-8939211	4.806387e-01	0.318
Inhibition of Host mRNA Processing and RNA Silencing	R-HSA-168315	2.392990e-01	0.621
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	2.392990e-01	0.621
CDC6 association with the ORC:origin complex	R-HSA-68689	1.660293e-01	0.780
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis	R-HSA-9708296	3.055936e-01	0.515
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	3.055936e-01	0.515
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	1.123555e-01	0.949
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	3.661142e-01	0.436
MET interacts with TNS proteins	R-HSA-8875513	3.661142e-01	0.436
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	2.036863e-01	0.691
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	4.213635e-01	0.375
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	1.621084e-01	0.790
Regulation of gene expression in early pancreatic precursor cells	R-HSA-210747	3.647947e-01	0.438
Bicarbonate transporters	R-HSA-425381	3.647947e-01	0.438
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	4.718002e-01	0.326
p53-Dependent G1 DNA Damage Response	R-HSA-69563	1.543025e-01	0.812
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	1.543025e-01	0.812
Ovarian tumor domain proteases	R-HSA-5689896	2.164068e-01	0.665
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	2.506864e-01	0.601
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	2.935604e-01	0.532
Signaling by AMER1 mutants	R-HSA-4839748	3.969371e-01	0.401
Signaling by AXIN mutants	R-HSA-4839735	3.969371e-01	0.401
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	2.133652e-01	0.671
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	3.495102e-01	0.457
PDE3B signalling	R-HSA-165160	5.178434e-01	0.286
Synthesis of PS	R-HSA-1483101	5.178434e-01	0.286
Ceramide signalling	R-HSA-193681	5.178434e-01	0.286
PKB-mediated events	R-HSA-109703	5.178434e-01	0.286
Viral Messenger RNA Synthesis	R-HSA-168325	2.966351e-01	0.528
Golgi-to-ER retrograde transport	R-HSA-8856688	2.009045e-01	0.697
Defective CFTR causes cystic fibrosis	R-HSA-5678895	3.544784e-01	0.450
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	5.598755e-01	0.252
G2/M DNA replication checkpoint	R-HSA-69478	5.598755e-01	0.252
Budding and maturation of HIV virion	R-HSA-162588	4.358330e-01	0.361
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	5.167897e-01	0.287
Metalloprotease DUBs	R-HSA-5689901	5.582204e-01	0.253
Opioid Signalling	R-HSA-111885	4.774682e-01	0.321
Regulation of TP53 Expression and Degradation	R-HSA-6806003	2.456085e-01	0.610
Signaling by EGFR	R-HSA-177929	1.357269e-01	0.867
DNA Repair	R-HSA-73894	4.308464e-01	0.366
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	3.342107e-01	0.476
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	5.582204e-01	0.253
Cell junction organization	R-HSA-446728	1.124019e-01	0.949
RNA Polymerase II Transcription	R-HSA-73857	1.942890e-01	0.712
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	2.149751e-01	0.668
Stabilization of p53	R-HSA-69541	1.314997e-01	0.881
Aggrephagy	R-HSA-9646399	4.266772e-01	0.370
Frs2-mediated activation	R-HSA-170968	4.587886e-01	0.338
NGF-stimulated transcription	R-HSA-9031628	2.531129e-01	0.597
Cell-cell junction organization	R-HSA-421270	1.217795e-01	0.914
VEGFA-VEGFR2 Pathway	R-HSA-4420097	2.059280e-01	0.686
RAF/MAP kinase cascade	R-HSA-5673001	5.386770e-01	0.269
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	1.807708e-01	0.743
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	1.437634e-01	0.842
Termination of translesion DNA synthesis	R-HSA-5656169	3.954577e-01	0.403
Signaling by FGFR in disease	R-HSA-1226099	4.719297e-01	0.326
Vesicle-mediated transport	R-HSA-5653656	3.590311e-01	0.445
Heme signaling	R-HSA-9707616	4.548547e-01	0.342
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.172316e-01	0.931
Acetylcholine regulates insulin secretion	R-HSA-399997	1.276524e-01	0.894
Signal attenuation	R-HSA-74749	3.320154e-01	0.479
Influenza Viral RNA Transcription and Replication	R-HSA-168273	1.709408e-01	0.767
Rab regulation of trafficking	R-HSA-9007101	2.220312e-01	0.654
Recycling pathway of L1	R-HSA-437239	3.864951e-01	0.413
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	5.150506e-01	0.288
Cell-Cell communication	R-HSA-1500931	1.851342e-01	0.733
G1/S DNA Damage Checkpoints	R-HSA-69615	2.047808e-01	0.689
Signaling by VEGF	R-HSA-194138	3.003537e-01	0.522
Resolution of Abasic Sites (AP sites)	R-HSA-73933	4.442848e-01	0.352
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	4.587886e-01	0.338
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	3.733497e-01	0.428
G2/M DNA damage checkpoint	R-HSA-69473	3.344702e-01	0.476
DCC mediated attractive signaling	R-HSA-418885	5.167897e-01	0.287
G-protein mediated events	R-HSA-112040	5.260635e-01	0.279
Signaling by NOTCH1 in Cancer	R-HSA-2644603	4.257089e-01	0.371
EGFR downregulation	R-HSA-182971	4.358330e-01	0.361
Signal Transduction	R-HSA-162582	1.831118e-01	0.737
Ca2+ pathway	R-HSA-4086398	3.219865e-01	0.492
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	4.314128e-01	0.365
CHL1 interactions	R-HSA-447041	2.317663e-01	0.635
Activation of PUMA and translocation to mitochondria	R-HSA-139915	2.317663e-01	0.635
Activation of NOXA and translocation to mitochondria	R-HSA-111448	4.213635e-01	0.375
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	1.250817e-01	0.903
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	1.750985e-01	0.757
Signaling by LTK	R-HSA-9842663	4.283047e-01	0.368
Regulation of TP53 Degradation	R-HSA-6804757	3.555198e-01	0.449
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	4.697208e-01	0.328
Signaling by NOTCH	R-HSA-157118	2.737426e-01	0.563
Transcriptional regulation by small RNAs	R-HSA-5578749	4.449722e-01	0.352
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	4.548547e-01	0.342
Fructose catabolism	R-HSA-70350	5.441994e-01	0.264
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	5.441994e-01	0.264
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	5.297347e-01	0.276
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	2.087678e-01	0.680
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	4.449722e-01	0.352
Signaling by TGFBR3	R-HSA-9839373	3.704747e-01	0.431
PI5P Regulates TP53 Acetylation	R-HSA-6811555	2.036863e-01	0.691
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	2.558005e-01	0.592
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	1.357269e-01	0.867
L1CAM interactions	R-HSA-373760	4.069533e-01	0.390
Activation of BH3-only proteins	R-HSA-114452	1.147237e-01	0.940
Semaphorin interactions	R-HSA-373755	1.198013e-01	0.922
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	3.740817e-01	0.427
Regulation of NF-kappa B signaling	R-HSA-9758274	5.441994e-01	0.264
PERK regulates gene expression	R-HSA-381042	5.326199e-01	0.274
Extra-nuclear estrogen signaling	R-HSA-9009391	3.270527e-01	0.485
Signaling by PTK6	R-HSA-8848021	2.047808e-01	0.689
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	2.047808e-01	0.689
Myogenesis	R-HSA-525793	3.342107e-01	0.476
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	4.548547e-01	0.342
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	4.926368e-01	0.307
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	4.543375e-01	0.343
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	1.660293e-01	0.780
Josephin domain DUBs	R-HSA-5689877	1.172316e-01	0.931
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	3.661142e-01	0.436
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	4.213635e-01	0.375
Protein methylation	R-HSA-8876725	2.512314e-01	0.600
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	2.512314e-01	0.600
Activation of SMO	R-HSA-5635838	2.755865e-01	0.560
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	2.755865e-01	0.560
RHOBTB3 ATPase cycle	R-HSA-9706019	3.647947e-01	0.438
Inositol transporters	R-HSA-429593	4.718002e-01	0.326
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	2.676941e-01	0.572
Negative regulation of NOTCH4 signaling	R-HSA-9604323	2.606185e-01	0.584
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	2.758603e-01	0.559
Negative feedback regulation of MAPK pathway	R-HSA-5674499	5.178434e-01	0.286
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	3.377244e-01	0.471
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	3.377244e-01	0.471
PTK6 promotes HIF1A stabilization	R-HSA-8857538	5.598755e-01	0.252
Integration of viral DNA into host genomic DNA	R-HSA-175567	5.598755e-01	0.252
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	4.557416e-01	0.341
Degradation of CRY and PER proteins	R-HSA-9932298	4.617558e-01	0.336
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	4.548547e-01	0.342
Glucagon signaling in metabolic regulation	R-HSA-163359	4.947995e-01	0.306
Gene Silencing by RNA	R-HSA-211000	5.222763e-01	0.282
RMTs methylate histone arginines	R-HSA-3214858	3.385340e-01	0.470
Prolonged ERK activation events	R-HSA-169893	5.441994e-01	0.264
Signaling by TGF-beta Receptor Complex	R-HSA-170834	3.975878e-01	0.401
Non-integrin membrane-ECM interactions	R-HSA-3000171	1.429842e-01	0.845
Protein hydroxylation	R-HSA-9629569	3.984633e-01	0.400
Degradation of CDH1	R-HSA-9766229	4.185008e-01	0.378
Suppression of phagosomal maturation	R-HSA-9637687	5.582204e-01	0.253
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	2.512314e-01	0.600
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	1.859759e-01	0.731
Suppression of apoptosis	R-HSA-9635465	3.647947e-01	0.438
PECAM1 interactions	R-HSA-210990	3.647947e-01	0.438
Interleukin-37 signaling	R-HSA-9008059	2.339663e-01	0.631
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	2.456085e-01	0.610
tRNA processing in the nucleus	R-HSA-6784531	3.097918e-01	0.509
Regulation of NFE2L2 gene expression	R-HSA-9818749	5.598755e-01	0.252
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	4.089636e-01	0.388
Selenocysteine synthesis	R-HSA-2408557	4.433394e-01	0.353
Regulation of RUNX2 expression and activity	R-HSA-8939902	2.966351e-01	0.528
Signal transduction by L1	R-HSA-445144	3.984633e-01	0.400
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	3.544784e-01	0.450
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	3.544784e-01	0.450
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	4.157238e-01	0.381
MHC class II antigen presentation	R-HSA-2132295	3.707670e-01	0.431
Selective autophagy	R-HSA-9663891	5.238064e-01	0.281
Specification of the neural plate border	R-HSA-9834899	3.740817e-01	0.427
Hedgehog ligand biogenesis	R-HSA-5358346	4.502912e-01	0.347
DNA Damage Bypass	R-HSA-73893	4.185008e-01	0.378
Glycolysis	R-HSA-70171	4.319095e-01	0.365
Influenza Infection	R-HSA-168255	1.463564e-01	0.835
Uptake and function of anthrax toxins	R-HSA-5210891	1.437634e-01	0.842
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	4.718002e-01	0.326
NrCAM interactions	R-HSA-447038	4.718002e-01	0.326
Leading Strand Synthesis	R-HSA-69109	4.283047e-01	0.368
Polymerase switching	R-HSA-69091	4.283047e-01	0.368
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	4.587886e-01	0.338
Vif-mediated degradation of APOBEC3G	R-HSA-180585	3.555198e-01	0.449
Glucagon-type ligand receptors	R-HSA-420092	3.954577e-01	0.403
Degradation of AXIN	R-HSA-4641257	3.733497e-01	0.428
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	3.733497e-01	0.428
CREB phosphorylation	R-HSA-199920	5.598755e-01	0.252
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	5.167897e-01	0.287
Free fatty acids regulate insulin secretion	R-HSA-400451	4.926368e-01	0.307
Negative regulation of FLT3	R-HSA-9706369	5.441994e-01	0.264
RET signaling	R-HSA-8853659	5.509944e-01	0.259
Signaling by NOTCH3	R-HSA-9012852	5.124993e-01	0.290
Signaling by ALK	R-HSA-201556	2.456085e-01	0.610
Response of Mtb to phagocytosis	R-HSA-9637690	4.961763e-01	0.304
Signaling by NOTCH2	R-HSA-1980145	5.138796e-01	0.289
Activation of ATR in response to replication stress	R-HSA-176187	2.849451e-01	0.545
Regulation of RUNX3 expression and activity	R-HSA-8941858	2.606185e-01	0.584
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	4.442848e-01	0.352
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	4.718002e-01	0.326
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	2.734733e-01	0.563
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	3.248374e-01	0.488
Vpu mediated degradation of CD4	R-HSA-180534	3.023957e-01	0.519
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	5.178434e-01	0.286
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	5.178434e-01	0.286
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	5.178434e-01	0.286
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	5.178434e-01	0.286
Regulation of Apoptosis	R-HSA-169911	3.377244e-01	0.471
Basigin interactions	R-HSA-210991	4.225759e-01	0.374
Nef and signal transduction	R-HSA-164944	5.598755e-01	0.252
HDL clearance	R-HSA-8964011	5.598755e-01	0.252
FOXO-mediated transcription	R-HSA-9614085	3.060256e-01	0.514
IRF3-mediated induction of type I IFN	R-HSA-3270619	5.167897e-01	0.287
Degradation of GLI2 by the proteasome	R-HSA-5610783	4.617558e-01	0.336
CREB3 factors activate genes	R-HSA-8874211	5.598755e-01	0.252
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	1.606218e-01	0.794
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	2.341104e-01	0.631
MAPK6/MAPK4 signaling	R-HSA-5687128	4.740821e-01	0.324
Inositol phosphate metabolism	R-HSA-1483249	3.447062e-01	0.463
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	1.495525e-01	0.825
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	5.178434e-01	0.286
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	3.750821e-01	0.426
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	5.441994e-01	0.264
RUNX2 regulates bone development	R-HSA-8941326	3.555198e-01	0.449
ChREBP activates metabolic gene expression	R-HSA-163765	3.647947e-01	0.438
Regulation of PTEN stability and activity	R-HSA-8948751	1.977579e-01	0.704
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	2.163325e-01	0.665
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	1.373897e-01	0.862
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	5.178434e-01	0.286
Intrinsic Pathway for Apoptosis	R-HSA-109606	3.670720e-01	0.435
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	4.442848e-01	0.352
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	5.297347e-01	0.276
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	2.922255e-01	0.534
Signaling by Leptin	R-HSA-2586552	3.320154e-01	0.479
Formation of paraxial mesoderm	R-HSA-9793380	2.966351e-01	0.528
FLT3 Signaling	R-HSA-9607240	4.442848e-01	0.352
Interleukin-7 signaling	R-HSA-1266695	5.369228e-01	0.270
Somitogenesis	R-HSA-9824272	5.297347e-01	0.276
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	5.622586e-01	0.250
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	5.622586e-01	0.250
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	5.670487e-01	0.246
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	5.705049e-01	0.244
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	5.705049e-01	0.244
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	5.705049e-01	0.244
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	5.705049e-01	0.244
Chromosome Maintenance	R-HSA-73886	5.736418e-01	0.241
Macroautophagy	R-HSA-1632852	5.783723e-01	0.238
Processive synthesis on the C-strand of the telomere	R-HSA-174414	5.789166e-01	0.237
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	5.789166e-01	0.237
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	5.789166e-01	0.237
CD28 dependent PI3K/Akt signaling	R-HSA-389357	5.789166e-01	0.237
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	5.789166e-01	0.237
Ub-specific processing proteases	R-HSA-5689880	5.807427e-01	0.236
MAPK1/MAPK3 signaling	R-HSA-5684996	5.860500e-01	0.232
RIPK1-mediated regulated necrosis	R-HSA-5213460	5.865575e-01	0.232
MET promotes cell motility	R-HSA-8875878	5.865575e-01	0.232
G2/M Transition	R-HSA-69275	5.952824e-01	0.225
Signaling by EGFRvIII in Cancer	R-HSA-5637812	5.956904e-01	0.225
Constitutive Signaling by EGFRvIII	R-HSA-5637810	5.956904e-01	0.225
PI3K events in ERBB2 signaling	R-HSA-1963642	5.956904e-01	0.225
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	5.956904e-01	0.225
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	5.956904e-01	0.225
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	5.956904e-01	0.225
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	5.956904e-01	0.225
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	5.956904e-01	0.225
Elevation of cytosolic Ca2+ levels	R-HSA-139853	5.956904e-01	0.225
Specification of primordial germ cells	R-HSA-9827857	5.956904e-01	0.225
MET activates PI3K/AKT signaling	R-HSA-8851907	5.982457e-01	0.223
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	5.982457e-01	0.223
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	5.982457e-01	0.223
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	5.982457e-01	0.223
NOSTRIN mediated eNOS trafficking	R-HSA-203641	5.982457e-01	0.223
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	5.982457e-01	0.223
Activated NTRK3 signals through PI3K	R-HSA-9603381	5.982457e-01	0.223
VLDL clearance	R-HSA-8964046	5.982457e-01	0.223
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	5.982457e-01	0.223
Regulation of PTEN localization	R-HSA-8948747	5.982457e-01	0.223
Uptake and function of diphtheria toxin	R-HSA-5336415	5.982457e-01	0.223
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	6.001605e-01	0.222
Mitotic G2-G2/M phases	R-HSA-453274	6.114682e-01	0.214
Activation of HOX genes during differentiation	R-HSA-5619507	6.123030e-01	0.213
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	6.123030e-01	0.213
TP53 Regulates Metabolic Genes	R-HSA-5628897	6.178633e-01	0.209
Signaling by Erythropoietin	R-HSA-9006335	6.184253e-01	0.209
Impaired BRCA2 binding to RAD51	R-HSA-9709570	6.184253e-01	0.209
Regulation of CDH11 Expression and Function	R-HSA-9759475	6.184253e-01	0.209
GAB1 signalosome	R-HSA-180292	6.197511e-01	0.208
RNA Polymerase III Transcription Termination	R-HSA-73980	6.197511e-01	0.208
FGFR1 ligand binding and activation	R-HSA-190242	6.197511e-01	0.208
Regulation of TP53 Activity through Methylation	R-HSA-6804760	6.197511e-01	0.208
FOXO-mediated transcription of cell death genes	R-HSA-9614657	6.197511e-01	0.208
Polo-like kinase mediated events	R-HSA-156711	6.197511e-01	0.208
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	6.197511e-01	0.208
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	6.197511e-01	0.208
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	6.204221e-01	0.207
Interleukin-2 family signaling	R-HSA-451927	6.204221e-01	0.207
Activation of NF-kappaB in B cells	R-HSA-1169091	6.236666e-01	0.205
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	6.239082e-01	0.205
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	6.239082e-01	0.205
MAPK family signaling cascades	R-HSA-5683057	6.245139e-01	0.204
Generic Transcription Pathway	R-HSA-212436	6.301896e-01	0.201
Protein ubiquitination	R-HSA-8852135	6.314278e-01	0.200
Type I hemidesmosome assembly	R-HSA-446107	6.332729e-01	0.198
RSK activation	R-HSA-444257	6.332729e-01	0.198
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	6.332729e-01	0.198
Signaling by MRAS-complex mutants	R-HSA-9660537	6.332729e-01	0.198
MET receptor recycling	R-HSA-8875656	6.332729e-01	0.198
Regulation of NPAS4 mRNA translation	R-HSA-9768778	6.332729e-01	0.198
Activated NTRK2 signals through PI3K	R-HSA-9028335	6.332729e-01	0.198
FGFR1b ligand binding and activation	R-HSA-190370	6.332729e-01	0.198
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	6.332729e-01	0.198
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	6.332729e-01	0.198
Regulation by c-FLIP	R-HSA-3371378	6.332729e-01	0.198
Downregulation of ERBB4 signaling	R-HSA-1253288	6.332729e-01	0.198
Dimerization of procaspase-8	R-HSA-69416	6.332729e-01	0.198
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	6.332729e-01	0.198
Adrenoceptors	R-HSA-390696	6.332729e-01	0.198
SARS-CoV-1-host interactions	R-HSA-9692914	6.333067e-01	0.198
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	6.354922e-01	0.197
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	6.372103e-01	0.196
Formation of RNA Pol II elongation complex	R-HSA-112382	6.381861e-01	0.195
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	6.381861e-01	0.195
Uptake and actions of bacterial toxins	R-HSA-5339562	6.381861e-01	0.195
Insulin receptor signalling cascade	R-HSA-74751	6.406593e-01	0.193
IKK complex recruitment mediated by RIP1	R-HSA-937041	6.426917e-01	0.192
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	6.426917e-01	0.192
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	6.426917e-01	0.192
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	6.426917e-01	0.192
Diseases of hemostasis	R-HSA-9671793	6.426917e-01	0.192
E2F mediated regulation of DNA replication	R-HSA-113510	6.426917e-01	0.192
STING mediated induction of host immune responses	R-HSA-1834941	6.426917e-01	0.192
Maturation of nucleoprotein	R-HSA-9694631	6.426917e-01	0.192
Rap1 signalling	R-HSA-392517	6.426917e-01	0.192
Post NMDA receptor activation events	R-HSA-438064	6.468750e-01	0.189
Glucose metabolism	R-HSA-70326	6.475402e-01	0.189
Signaling by NTRK1 (TRKA)	R-HSA-187037	6.514287e-01	0.186
RNA Polymerase II Transcription Elongation	R-HSA-75955	6.523540e-01	0.186
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	6.524860e-01	0.185
HIV Transcription Initiation	R-HSA-167161	6.524860e-01	0.185
RNA Polymerase II Transcription Initiation	R-HSA-75953	6.524860e-01	0.185
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	6.524860e-01	0.185
Negative regulation of MAPK pathway	R-HSA-5675221	6.524860e-01	0.185
SLC-mediated transport of neurotransmitters	R-HSA-442660	6.524860e-01	0.185
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	6.535970e-01	0.185
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	6.536923e-01	0.185
Antigen processing-Cross presentation	R-HSA-1236975	6.536923e-01	0.185
Signaling by TGFB family members	R-HSA-9006936	6.544032e-01	0.184
Trafficking of AMPA receptors	R-HSA-399719	6.553380e-01	0.184
Homology Directed Repair	R-HSA-5693538	6.571494e-01	0.182
Gastrulation	R-HSA-9758941	6.589693e-01	0.181
Regulation of insulin secretion	R-HSA-422356	6.607675e-01	0.180
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	6.645247e-01	0.177
Formation of definitive endoderm	R-HSA-9823730	6.645247e-01	0.177
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	6.652480e-01	0.177
Regulated proteolysis of p75NTR	R-HSA-193692	6.652480e-01	0.177
Interleukin-21 signaling	R-HSA-9020958	6.652480e-01	0.177
WNT mediated activation of DVL	R-HSA-201688	6.652480e-01	0.177
CASP8 activity is inhibited	R-HSA-5218900	6.652480e-01	0.177
Calcineurin activates NFAT	R-HSA-2025928	6.652480e-01	0.177
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	6.652480e-01	0.177
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	6.652480e-01	0.177
Regulation of signaling by NODAL	R-HSA-1433617	6.652480e-01	0.177
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	6.652480e-01	0.177
Regulation of CDH11 gene transcription	R-HSA-9762293	6.652480e-01	0.177
Respiratory syncytial virus genome replication	R-HSA-9834752	6.652480e-01	0.177
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	6.652480e-01	0.177
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	6.661635e-01	0.176
Regulation of PD-L1(CD274) expression	R-HSA-9909648	6.661917e-01	0.176
PCP/CE pathway	R-HSA-4086400	6.673251e-01	0.176
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	6.678217e-01	0.175
Ca-dependent events	R-HSA-111996	6.678217e-01	0.175
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	6.678217e-01	0.175
p75 NTR receptor-mediated signalling	R-HSA-193704	6.710967e-01	0.173
Inwardly rectifying K+ channels	R-HSA-1296065	6.728051e-01	0.172
HDR through Homologous Recombination (HRR)	R-HSA-5685942	6.785959e-01	0.168
G alpha (z) signalling events	R-HSA-418597	6.796094e-01	0.168
RNA Polymerase II Promoter Escape	R-HSA-73776	6.826864e-01	0.166
Interleukin-1 family signaling	R-HSA-446652	6.838967e-01	0.165
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	6.852687e-01	0.164
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	6.852687e-01	0.164
TNFR1-induced proapoptotic signaling	R-HSA-5357786	6.852687e-01	0.164
MyD88 deficiency (TLR2/4)	R-HSA-5602498	6.852687e-01	0.164
Zygotic genome activation (ZGA)	R-HSA-9819196	6.852687e-01	0.164
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	6.896117e-01	0.161
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	6.896117e-01	0.161
Integrin signaling	R-HSA-354192	6.896117e-01	0.161
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	6.896117e-01	0.161
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	6.896117e-01	0.161
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	6.896117e-01	0.161
Negative regulation of FGFR1 signaling	R-HSA-5654726	6.896117e-01	0.161
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	6.900218e-01	0.161
Regulated Necrosis	R-HSA-5218859	6.906482e-01	0.161
Interleukin-1 signaling	R-HSA-9020702	6.911840e-01	0.160
TNF signaling	R-HSA-75893	6.926879e-01	0.159
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	6.944370e-01	0.158
MAPK3 (ERK1) activation	R-HSA-110056	6.944370e-01	0.158
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	6.944370e-01	0.158
Folding of actin by CCT/TriC	R-HSA-390450	6.944370e-01	0.158
Regulation of CDH11 function	R-HSA-9762292	6.944370e-01	0.158
Binding and entry of HIV virion	R-HSA-173107	6.944370e-01	0.158
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	6.944370e-01	0.158
DNA replication initiation	R-HSA-68952	6.944370e-01	0.158
Metal sequestration by antimicrobial proteins	R-HSA-6799990	6.944370e-01	0.158
Receptor Mediated Mitophagy	R-HSA-8934903	6.944370e-01	0.158
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	6.944370e-01	0.158
Defective factor IX causes hemophilia B	R-HSA-9668250	6.944370e-01	0.158
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	6.944370e-01	0.158
Formation of apoptosome	R-HSA-111458	6.944370e-01	0.158
Regulation of the apoptosome activity	R-HSA-9627069	6.944370e-01	0.158
Death Receptor Signaling	R-HSA-73887	6.999175e-01	0.155
Processing of DNA double-strand break ends	R-HSA-5693607	7.009882e-01	0.154
Maternal to zygotic transition (MZT)	R-HSA-9816359	7.029253e-01	0.153
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	7.049476e-01	0.152
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	7.049476e-01	0.152
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	7.049476e-01	0.152
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	7.049476e-01	0.152
Signaling by PDGFR in disease	R-HSA-9671555	7.049476e-01	0.152
Resolution of D-Loop Structures	R-HSA-5693537	7.057608e-01	0.151
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	7.057608e-01	0.151
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	7.108455e-01	0.148
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	7.109946e-01	0.148
Fanconi Anemia Pathway	R-HSA-6783310	7.109946e-01	0.148
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	7.109946e-01	0.148
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	7.131402e-01	0.147
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	7.138427e-01	0.146
Autophagy	R-HSA-9612973	7.154436e-01	0.145
Dual incision in TC-NER	R-HSA-6782135	7.177328e-01	0.144
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	7.210824e-01	0.142
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	7.210824e-01	0.142
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	7.210824e-01	0.142
Synthesis of PIPs at the ER membrane	R-HSA-1483248	7.210824e-01	0.142
vRNP Assembly	R-HSA-192905	7.210824e-01	0.142
SARS-CoV-2 modulates autophagy	R-HSA-9754560	7.210824e-01	0.142
Prostanoid ligand receptors	R-HSA-391908	7.210824e-01	0.142
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	7.212582e-01	0.142
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	7.212582e-01	0.142
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	7.212582e-01	0.142
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	7.212582e-01	0.142
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	7.221450e-01	0.141
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	7.235895e-01	0.141
Fructose metabolism	R-HSA-5652084	7.235895e-01	0.141
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	7.235895e-01	0.141
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	7.235895e-01	0.141
Diseases of DNA repair	R-HSA-9675135	7.244382e-01	0.140
Extension of Telomeres	R-HSA-180786	7.296975e-01	0.137
Amino acid transport across the plasma membrane	R-HSA-352230	7.296975e-01	0.137
Cellular response to starvation	R-HSA-9711097	7.304638e-01	0.136
Downstream signaling of activated FGFR1	R-HSA-5654687	7.361120e-01	0.133
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	7.361120e-01	0.133
SARS-CoV-2-host interactions	R-HSA-9705683	7.386893e-01	0.132
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	7.412255e-01	0.130
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	7.412255e-01	0.130
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	7.412255e-01	0.130
Syndecan interactions	R-HSA-3000170	7.412255e-01	0.130
Growth hormone receptor signaling	R-HSA-982772	7.412255e-01	0.130
Metabolism of polyamines	R-HSA-351202	7.412908e-01	0.130
Meiosis	R-HSA-1500620	7.422580e-01	0.129
Protein-protein interactions at synapses	R-HSA-6794362	7.422580e-01	0.129
Signaling by NTRKs	R-HSA-166520	7.445783e-01	0.128
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	7.454058e-01	0.128
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	7.454058e-01	0.128
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	7.454058e-01	0.128
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	7.454058e-01	0.128
NF-kB is activated and signals survival	R-HSA-209560	7.454058e-01	0.128
Plasmalogen biosynthesis	R-HSA-75896	7.454058e-01	0.128
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	7.454058e-01	0.128
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	7.454058e-01	0.128
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	7.454058e-01	0.128
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	7.454058e-01	0.128
Activation of RAC1	R-HSA-428540	7.454058e-01	0.128
Anchoring fibril formation	R-HSA-2214320	7.454058e-01	0.128
Cytochrome c-mediated apoptotic response	R-HSA-111461	7.454058e-01	0.128
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	7.454058e-01	0.128
GPER1 signaling	R-HSA-9634597	7.499164e-01	0.125
Intraflagellar transport	R-HSA-5620924	7.499164e-01	0.125
Co-stimulation by CD28	R-HSA-389356	7.499164e-01	0.125
PRC2 methylates histones and DNA	R-HSA-212300	7.503322e-01	0.125
Glycosphingolipid transport	R-HSA-9845576	7.503322e-01	0.125
Aquaporin-mediated transport	R-HSA-445717	7.525145e-01	0.123
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	7.577309e-01	0.120
SHC-mediated cascade:FGFR1	R-HSA-5654688	7.578891e-01	0.120
Mitochondrial RNA degradation	R-HSA-9836573	7.578891e-01	0.120
Neurodegenerative Diseases	R-HSA-8863678	7.578891e-01	0.120
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	7.578891e-01	0.120
Interferon Signaling	R-HSA-913531	7.611551e-01	0.119
Gap junction trafficking and regulation	R-HSA-157858	7.619597e-01	0.118
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	7.619597e-01	0.118
SIRT1 negatively regulates rRNA expression	R-HSA-427359	7.639308e-01	0.117
p75NTR recruits signalling complexes	R-HSA-209543	7.676093e-01	0.115
Scavenging by Class F Receptors	R-HSA-3000484	7.676093e-01	0.115
SHC-related events triggered by IGF1R	R-HSA-2428933	7.676093e-01	0.115
Serotonin clearance from the synaptic cleft	R-HSA-380615	7.676093e-01	0.115
Diseases associated with surfactant metabolism	R-HSA-5687613	7.676093e-01	0.115
MET activates RAS signaling	R-HSA-8851805	7.676093e-01	0.115
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	7.676093e-01	0.115
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	7.676093e-01	0.115
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	7.676093e-01	0.115
Negative regulation of the PI3K/AKT network	R-HSA-199418	7.678064e-01	0.115
SARS-CoV-1 Infection	R-HSA-9678108	7.721837e-01	0.112
FRS-mediated FGFR1 signaling	R-HSA-5654693	7.736160e-01	0.111
Long-term potentiation	R-HSA-9620244	7.736160e-01	0.111
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	7.736160e-01	0.111
Acyl chain remodelling of PS	R-HSA-1482801	7.736160e-01	0.111
HDMs demethylate histones	R-HSA-3214842	7.736160e-01	0.111
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	7.738633e-01	0.111
Interleukin-12 signaling	R-HSA-9020591	7.760810e-01	0.110
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	7.769211e-01	0.110
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	7.769211e-01	0.110
Diseases of programmed cell death	R-HSA-9645723	7.793483e-01	0.108
TCR signaling	R-HSA-202403	7.796783e-01	0.108
Muscle contraction	R-HSA-397014	7.843702e-01	0.105
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	7.853918e-01	0.105
PDH complex synthesizes acetyl-CoA from PYR	R-HSA-9861559	7.878776e-01	0.104
FGFR1c ligand binding and activation	R-HSA-190373	7.878776e-01	0.104
Diseases of nucleotide metabolism	R-HSA-9735804	7.878776e-01	0.104
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	7.878776e-01	0.104
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	7.878776e-01	0.104
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	7.878776e-01	0.104
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	7.878776e-01	0.104
Maturation of nucleoprotein	R-HSA-9683610	7.878776e-01	0.104
Replication of the SARS-CoV-1 genome	R-HSA-9682706	7.878776e-01	0.104
ER-Phagosome pathway	R-HSA-1236974	7.879732e-01	0.103
Signaling by EGFR in Cancer	R-HSA-1643713	7.884426e-01	0.103
Signaling by FLT3 fusion proteins	R-HSA-9703465	7.884426e-01	0.103
TRP channels	R-HSA-3295583	7.884426e-01	0.103
Urea cycle	R-HSA-70635	7.884426e-01	0.103
ABC-family proteins mediated transport	R-HSA-382556	7.912542e-01	0.102
ABC transporter disorders	R-HSA-5619084	7.944054e-01	0.100
Neurexins and neuroligins	R-HSA-6794361	7.953829e-01	0.099
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	7.963428e-01	0.099
Formation of Incision Complex in GG-NER	R-HSA-5696395	8.011362e-01	0.096
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	8.011362e-01	0.096
Diseases of Immune System	R-HSA-5260271	8.011362e-01	0.096
Diseases associated with the TLR signaling cascade	R-HSA-5602358	8.011362e-01	0.096
Generation of second messenger molecules	R-HSA-202433	8.011362e-01	0.096
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	8.024063e-01	0.096
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	8.024063e-01	0.096
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	8.024063e-01	0.096
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	8.024063e-01	0.096
Cristae formation	R-HSA-8949613	8.024063e-01	0.096
ER Quality Control Compartment (ERQC)	R-HSA-901032	8.024063e-01	0.096
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	8.031252e-01	0.095
Transcriptional Regulation by MECP2	R-HSA-8986944	8.044594e-01	0.094
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	8.052331e-01	0.094
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	8.063793e-01	0.093
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	8.063793e-01	0.093
NRIF signals cell death from the nucleus	R-HSA-205043	8.063793e-01	0.093
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	8.063793e-01	0.093
Signaling by FGFR4 in disease	R-HSA-5655291	8.063793e-01	0.093
Signal regulatory protein family interactions	R-HSA-391160	8.063793e-01	0.093
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	8.063793e-01	0.093
Vitamin B2 (riboflavin) metabolism	R-HSA-196843	8.063793e-01	0.093
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.063793e-01	0.093
Malate-aspartate shuttle	R-HSA-9856872	8.063793e-01	0.093
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	8.063793e-01	0.093
Regulation of KIT signaling	R-HSA-1433559	8.063793e-01	0.093
HDL assembly	R-HSA-8963896	8.063793e-01	0.093
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	8.063793e-01	0.093
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	8.066674e-01	0.093
PI Metabolism	R-HSA-1483255	8.066674e-01	0.093
Cellular responses to mechanical stimuli	R-HSA-9855142	8.094306e-01	0.092
Signaling by MET	R-HSA-6806834	8.115551e-01	0.091
SLC-mediated transport of amino acids	R-HSA-9958863	8.122823e-01	0.090
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	8.123932e-01	0.090
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	8.155448e-01	0.089
Formation of the Early Elongation Complex	R-HSA-113418	8.155448e-01	0.089
HIV elongation arrest and recovery	R-HSA-167287	8.155448e-01	0.089
Pausing and recovery of HIV elongation	R-HSA-167290	8.155448e-01	0.089
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	8.155448e-01	0.089
Pyroptosis	R-HSA-5620971	8.155448e-01	0.089
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	8.196994e-01	0.086
Transcription of the HIV genome	R-HSA-167172	8.210267e-01	0.086
Response of endothelial cells to shear stress	R-HSA-9860931	8.212019e-01	0.086
Integration of energy metabolism	R-HSA-163685	8.221105e-01	0.085
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	8.232683e-01	0.084
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	8.232683e-01	0.084
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	8.232683e-01	0.084
ERBB2 Regulates Cell Motility	R-HSA-6785631	8.232683e-01	0.084
p75NTR signals via NF-kB	R-HSA-193639	8.232683e-01	0.084
Sema3A PAK dependent Axon repulsion	R-HSA-399954	8.232683e-01	0.084
FASTK family proteins regulate processing and stability of mitochondrial RNAs	R-HSA-9837092	8.232683e-01	0.084
Spry regulation of FGF signaling	R-HSA-1295596	8.232683e-01	0.084
DNA Damage Reversal	R-HSA-73942	8.232683e-01	0.084
DNA methylation	R-HSA-5334118	8.278958e-01	0.082
mRNA Capping	R-HSA-72086	8.278958e-01	0.082
DARPP-32 events	R-HSA-180024	8.278958e-01	0.082
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	8.278958e-01	0.082
Platelet calcium homeostasis	R-HSA-418360	8.278958e-01	0.082
Activation of GABAB receptors	R-HSA-991365	8.332913e-01	0.079
GABA B receptor activation	R-HSA-977444	8.332913e-01	0.079
Signaling by FGFR1	R-HSA-5654736	8.339459e-01	0.079
Ion homeostasis	R-HSA-5578775	8.339459e-01	0.079
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	8.348779e-01	0.078
Signaling by Interleukins	R-HSA-449147	8.371911e-01	0.077
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	8.375281e-01	0.077
Interleukin-17 signaling	R-HSA-448424	8.375281e-01	0.077
WNT5A-dependent internalization of FZD4	R-HSA-5099900	8.386849e-01	0.076
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	8.386849e-01	0.076
Killing mechanisms	R-HSA-9664420	8.386849e-01	0.076
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	8.386849e-01	0.076
Differentiation of T cells	R-HSA-9945266	8.386849e-01	0.076
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	8.386849e-01	0.076
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	8.386849e-01	0.076
Attachment and Entry	R-HSA-9678110	8.386849e-01	0.076
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	8.394967e-01	0.076
SHC1 events in ERBB2 signaling	R-HSA-1250196	8.394967e-01	0.076
GABA synthesis, release, reuptake and degradation	R-HSA-888590	8.394967e-01	0.076
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.394967e-01	0.076
KEAP1-NFE2L2 pathway	R-HSA-9755511	8.421315e-01	0.075
Defective pyroptosis	R-HSA-9710421	8.429680e-01	0.074
Co-inhibition by PD-1	R-HSA-389948	8.434256e-01	0.074
Developmental Biology	R-HSA-1266738	8.483617e-01	0.071
Translation	R-HSA-72766	8.498541e-01	0.071
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	8.503842e-01	0.070
Molecules associated with elastic fibres	R-HSA-2129379	8.503842e-01	0.070
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	8.503842e-01	0.070
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	8.508338e-01	0.070
Early SARS-CoV-2 Infection Events	R-HSA-9772572	8.508338e-01	0.070
Surfactant metabolism	R-HSA-5683826	8.521540e-01	0.069
Gap junction trafficking	R-HSA-190828	8.521540e-01	0.069
GRB2 events in ERBB2 signaling	R-HSA-1963640	8.527576e-01	0.069
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	8.527576e-01	0.069
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	8.527576e-01	0.069
Transcriptional regulation of testis differentiation	R-HSA-9690406	8.527576e-01	0.069
TRAF3-dependent IRF activation pathway	R-HSA-918233	8.527576e-01	0.069
Passive transport by Aquaporins	R-HSA-432047	8.527576e-01	0.069
Fibronectin matrix formation	R-HSA-1566977	8.527576e-01	0.069
Coenzyme A biosynthesis	R-HSA-196783	8.527576e-01	0.069
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	8.527576e-01	0.069
tRNA modification in the mitochondrion	R-HSA-6787450	8.527576e-01	0.069
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	8.527576e-01	0.069
Stimuli-sensing channels	R-HSA-2672351	8.538348e-01	0.069
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	8.540474e-01	0.069
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	8.540474e-01	0.069
Class I MHC mediated antigen processing & presentation	R-HSA-983169	8.556111e-01	0.068
Adipogenesis	R-HSA-9843745	8.602434e-01	0.065
Signaling by WNT in cancer	R-HSA-4791275	8.605946e-01	0.065
Telomere Maintenance	R-HSA-157579	8.606858e-01	0.065
MyD88-independent TLR4 cascade	R-HSA-166166	8.654741e-01	0.063
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	8.654741e-01	0.063
Regulation of NPAS4 gene expression	R-HSA-9768759	8.656034e-01	0.063
Catecholamine biosynthesis	R-HSA-209905	8.656034e-01	0.063
Replication of the SARS-CoV-2 genome	R-HSA-9694686	8.656034e-01	0.063
Signaling by Nuclear Receptors	R-HSA-9006931	8.656931e-01	0.063
Signaling by FGFR	R-HSA-190236	8.666850e-01	0.062
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	8.691269e-01	0.061
Regulation of pyruvate metabolism	R-HSA-9861718	8.691269e-01	0.061
Interleukin-12 family signaling	R-HSA-447115	8.691336e-01	0.061
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	8.701631e-01	0.060
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	8.704351e-01	0.060
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	8.704351e-01	0.060
MAP kinase activation	R-HSA-450294	8.734217e-01	0.059
Regulation of T cell activation by CD28 family	R-HSA-388841	8.751058e-01	0.058
Synthesis of PC	R-HSA-1483191	8.769501e-01	0.057
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	8.773292e-01	0.057
PKA activation	R-HSA-163615	8.773292e-01	0.057
PKA activation in glucagon signalling	R-HSA-164378	8.773292e-01	0.057
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	8.773292e-01	0.057
Synaptic adhesion-like molecules	R-HSA-8849932	8.773292e-01	0.057
Platelet sensitization by LDL	R-HSA-432142	8.773292e-01	0.057
Apoptotic factor-mediated response	R-HSA-111471	8.773292e-01	0.057
Effects of PIP2 hydrolysis	R-HSA-114508	8.791240e-01	0.056
Miscellaneous transport and binding events	R-HSA-5223345	8.791240e-01	0.056
Transcriptional regulation of granulopoiesis	R-HSA-9616222	8.802651e-01	0.055
HCMV Early Events	R-HSA-9609690	8.803271e-01	0.055
Neddylation	R-HSA-8951664	8.835801e-01	0.054
Base Excision Repair	R-HSA-73884	8.865724e-01	0.052
Downstream TCR signaling	R-HSA-202424	8.865724e-01	0.052
eNOS activation	R-HSA-203615	8.875103e-01	0.052
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	8.875103e-01	0.052
NOD1/2 Signaling Pathway	R-HSA-168638	8.875103e-01	0.052
Mitophagy	R-HSA-5205647	8.875103e-01	0.052
Calnexin/calreticulin cycle	R-HSA-901042	8.875103e-01	0.052
PI-3K cascade:FGFR3	R-HSA-5654710	8.880326e-01	0.052
Crosslinking of collagen fibrils	R-HSA-2243919	8.880326e-01	0.052
Signaling by FGFR2 IIIa TM	R-HSA-8851708	8.880326e-01	0.052
Germ layer formation at gastrulation	R-HSA-9754189	8.880326e-01	0.052
Translesion Synthesis by POLH	R-HSA-110320	8.880326e-01	0.052
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	8.880326e-01	0.052
Regulation of signaling by CBL	R-HSA-912631	8.880326e-01	0.052
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	8.880326e-01	0.052
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	8.890957e-01	0.051
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	8.899301e-01	0.051
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	8.899301e-01	0.051
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	8.899301e-01	0.051
Pre-NOTCH Transcription and Translation	R-HSA-1912408	8.919302e-01	0.050
Signalling to ERKs	R-HSA-187687	8.953542e-01	0.048
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	8.953542e-01	0.048
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	8.959303e-01	0.048
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	8.964012e-01	0.047
Regulation of PD-L1(CD274) translation	R-HSA-9909620	8.978026e-01	0.047
PI-3K cascade:FGFR4	R-HSA-5654720	8.978026e-01	0.047
Negative regulation of MET activity	R-HSA-6807004	8.978026e-01	0.047
Post-chaperonin tubulin folding pathway	R-HSA-389977	8.978026e-01	0.047
Wax and plasmalogen biosynthesis	R-HSA-8848584	8.978026e-01	0.047
Signaling by NODAL	R-HSA-1181150	8.978026e-01	0.047
Nephrin family interactions	R-HSA-373753	8.978026e-01	0.047
Eicosanoid ligand-binding receptors	R-HSA-391903	8.978026e-01	0.047
Cytokine Signaling in Immune system	R-HSA-1280215	9.011399e-01	0.045
Signaling by Insulin receptor	R-HSA-74752	9.020010e-01	0.045
Signaling by FGFR2	R-HSA-5654738	9.022633e-01	0.045
FLT3 signaling in disease	R-HSA-9682385	9.026863e-01	0.044
Cilium Assembly	R-HSA-5617833	9.050592e-01	0.043
Hemostasis	R-HSA-109582	9.062300e-01	0.043
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	9.067207e-01	0.043
PKA-mediated phosphorylation of CREB	R-HSA-111931	9.067207e-01	0.043
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.067207e-01	0.043
ERK/MAPK targets	R-HSA-198753	9.067207e-01	0.043
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.067207e-01	0.043
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	9.067207e-01	0.043
Mitochondrial biogenesis	R-HSA-1592230	9.088485e-01	0.042
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.094662e-01	0.041
Metabolism of folate and pterines	R-HSA-196757	9.095363e-01	0.041
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	9.112542e-01	0.040
Platelet homeostasis	R-HSA-418346	9.116437e-01	0.040
Reproduction	R-HSA-1474165	9.145651e-01	0.039
Listeria monocytogenes entry into host cells	R-HSA-8876384	9.148610e-01	0.039
Signaling by NTRK3 (TRKC)	R-HSA-9034015	9.148610e-01	0.039
Attachment and Entry	R-HSA-9694614	9.148610e-01	0.039
Ribavirin ADME	R-HSA-9755088	9.148610e-01	0.039
PPARA activates gene expression	R-HSA-1989781	9.156144e-01	0.038
Elastic fibre formation	R-HSA-1566948	9.159324e-01	0.038
SLC-mediated transport of inorganic anions	R-HSA-9958790	9.159324e-01	0.038
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	9.159324e-01	0.038
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	9.196463e-01	0.036
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	9.197443e-01	0.036
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	9.219016e-01	0.035
Plasma lipoprotein clearance	R-HSA-8964043	9.219016e-01	0.035
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.219016e-01	0.035
RAF-independent MAPK1/3 activation	R-HSA-112409	9.222914e-01	0.035
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	9.222914e-01	0.035
Ethanol oxidation	R-HSA-71384	9.222914e-01	0.035
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.222914e-01	0.035
LDL clearance	R-HSA-8964038	9.222914e-01	0.035
MyD88 dependent cascade initiated on endosome	R-HSA-975155	9.234067e-01	0.035
COPI-mediated anterograde transport	R-HSA-6807878	9.237103e-01	0.034
CLEC7A (Dectin-1) signaling	R-HSA-5607764	9.237103e-01	0.034
tRNA processing	R-HSA-72306	9.243742e-01	0.034
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	9.259335e-01	0.033
SARS-CoV-2 Infection	R-HSA-9694516	9.268834e-01	0.033
Inhibition of DNA recombination at telomere	R-HSA-9670095	9.274698e-01	0.033
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	9.274698e-01	0.033
HIV Transcription Elongation	R-HSA-167169	9.274698e-01	0.033
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	9.274698e-01	0.033
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	9.274698e-01	0.033
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	9.274698e-01	0.033
Platelet activation, signaling and aggregation	R-HSA-76002	9.281696e-01	0.032
Regulation of PTEN mRNA translation	R-HSA-8943723	9.290737e-01	0.032
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	9.306260e-01	0.031
Post-translational protein phosphorylation	R-HSA-8957275	9.311369e-01	0.031
MyD88 cascade initiated on plasma membrane	R-HSA-975871	9.311369e-01	0.031
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	9.311369e-01	0.031
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	9.311369e-01	0.031
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	9.326614e-01	0.030
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	9.352645e-01	0.029
CD209 (DC-SIGN) signaling	R-HSA-5621575	9.352645e-01	0.029
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	9.352645e-01	0.029
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	9.352645e-01	0.029
Synthesis of dolichyl-phosphate	R-HSA-446199	9.352645e-01	0.029
Plasma lipoprotein assembly	R-HSA-8963898	9.352645e-01	0.029
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	9.369562e-01	0.028
Intra-Golgi traffic	R-HSA-6811438	9.374997e-01	0.028
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	9.374997e-01	0.028
PI-3K cascade:FGFR2	R-HSA-5654695	9.409152e-01	0.026
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.409152e-01	0.026
Defects in cobalamin (B12) metabolism	R-HSA-3296469	9.409152e-01	0.026
Hyaluronan degradation	R-HSA-2160916	9.409152e-01	0.026
Laminin interactions	R-HSA-3000157	9.409152e-01	0.026
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.409152e-01	0.026
Selenoamino acid metabolism	R-HSA-2408522	9.416707e-01	0.026
Cytosolic tRNA aminoacylation	R-HSA-379716	9.420069e-01	0.026
Peroxisomal protein import	R-HSA-9033241	9.430318e-01	0.025
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.438308e-01	0.025
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	9.460729e-01	0.024
MET activates PTK2 signaling	R-HSA-8874081	9.460729e-01	0.024
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.460729e-01	0.024
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	9.460729e-01	0.024
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.460729e-01	0.024
Signaling by FGFR4	R-HSA-5654743	9.462037e-01	0.024
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	9.462037e-01	0.024
Neurotransmitter release cycle	R-HSA-112310	9.463928e-01	0.024
GABA receptor activation	R-HSA-977443	9.466931e-01	0.024
tRNA Aminoacylation	R-HSA-379724	9.466931e-01	0.024
Parasite infection	R-HSA-9664407	9.476614e-01	0.023
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.476614e-01	0.023
Leishmania phagocytosis	R-HSA-9664417	9.476614e-01	0.023
Netrin-1 signaling	R-HSA-373752	9.501102e-01	0.022
Packaging Of Telomere Ends	R-HSA-171306	9.507807e-01	0.022
Cobalamin (Cbl) metabolism	R-HSA-9759218	9.507807e-01	0.022
RNA Polymerase I Transcription Termination	R-HSA-73863	9.507807e-01	0.022
RNA Polymerase I Promoter Opening	R-HSA-73728	9.507807e-01	0.022
Signaling by FGFR3 in disease	R-HSA-5655332	9.507807e-01	0.022
Insulin processing	R-HSA-264876	9.507807e-01	0.022
Signaling by NTRK2 (TRKB)	R-HSA-9006115	9.507807e-01	0.022
Nuclear Receptor transcription pathway	R-HSA-383280	9.532133e-01	0.021
RNA Polymerase I Transcription	R-HSA-73864	9.532133e-01	0.021
Signaling by FGFR3	R-HSA-5654741	9.537449e-01	0.021
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	9.544544e-01	0.020
Telomere Extension By Telomerase	R-HSA-171319	9.550778e-01	0.020
Activation of AMPK downstream of NMDARs	R-HSA-9619483	9.550778e-01	0.020
Phase 0 - rapid depolarisation	R-HSA-5576892	9.550778e-01	0.020
Pyrimidine salvage	R-HSA-73614	9.550778e-01	0.020
Negative regulation of FGFR3 signaling	R-HSA-5654732	9.550778e-01	0.020
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	9.550778e-01	0.020
HCMV Late Events	R-HSA-9610379	9.565228e-01	0.019
Condensation of Prophase Chromosomes	R-HSA-2299718	9.571255e-01	0.019
HCMV Infection	R-HSA-9609646	9.571365e-01	0.019
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.590000e-01	0.018
Downstream signaling of activated FGFR3	R-HSA-5654708	9.590000e-01	0.018
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.590000e-01	0.018
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	9.590000e-01	0.018
Negative regulation of FGFR4 signaling	R-HSA-5654733	9.590000e-01	0.018
Ion transport by P-type ATPases	R-HSA-936837	9.592544e-01	0.018
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	9.602687e-01	0.018
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	9.619740e-01	0.017
Nuclear events mediated by NFE2L2	R-HSA-9759194	9.620018e-01	0.017
DAP12 signaling	R-HSA-2424491	9.625799e-01	0.017
Downstream signaling of activated FGFR4	R-HSA-5654716	9.625799e-01	0.017
Neurotransmitter clearance	R-HSA-112311	9.625799e-01	0.017
Gluconeogenesis	R-HSA-70263	9.631901e-01	0.016
Organelle biogenesis and maintenance	R-HSA-1852241	9.634663e-01	0.016
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	9.634839e-01	0.016
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.637944e-01	0.016
ER to Golgi Anterograde Transport	R-HSA-199977	9.640476e-01	0.016
Cellular response to chemical stress	R-HSA-9711123	9.640996e-01	0.016
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.644381e-01	0.016
Cytoprotection by HMOX1	R-HSA-9707564	9.657020e-01	0.015
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.658474e-01	0.015
Evasion by RSV of host interferon responses	R-HSA-9833109	9.658474e-01	0.015
Downstream signal transduction	R-HSA-186763	9.658474e-01	0.015
Chemokine receptors bind chemokines	R-HSA-380108	9.659045e-01	0.015
Transmission across Chemical Synapses	R-HSA-112315	9.670661e-01	0.015
Signaling by FGFR2 in disease	R-HSA-5655253	9.684258e-01	0.014
Toll-like Receptor Cascades	R-HSA-168898	9.684308e-01	0.014
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	9.688298e-01	0.014
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.696271e-01	0.013
Viral Infection Pathways	R-HSA-9824446	9.699243e-01	0.013
Meiotic recombination	R-HSA-912446	9.707669e-01	0.013
Pre-NOTCH Expression and Processing	R-HSA-1912422	9.708908e-01	0.013
Disorders of transmembrane transporters	R-HSA-5619115	9.712460e-01	0.013
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.715519e-01	0.013
SLC transporter disorders	R-HSA-5619102	9.726418e-01	0.012
RNA Polymerase I Promoter Escape	R-HSA-73772	9.729401e-01	0.012
COPII-mediated vesicle transport	R-HSA-204005	9.729972e-01	0.012
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.739857e-01	0.011
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	9.740365e-01	0.011
Acyl chain remodelling of PC	R-HSA-1482788	9.740365e-01	0.011
Cargo trafficking to the periciliary membrane	R-HSA-5620920	9.748093e-01	0.011
Hyaluronan metabolism	R-HSA-2142845	9.763041e-01	0.010
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.763041e-01	0.010
RA biosynthesis pathway	R-HSA-5365859	9.763041e-01	0.010
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.763041e-01	0.010
Negative regulation of FGFR2 signaling	R-HSA-5654727	9.763041e-01	0.010
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	9.763041e-01	0.010
Downstream signaling of activated FGFR2	R-HSA-5654696	9.783739e-01	0.009
Acyl chain remodelling of PE	R-HSA-1482839	9.783739e-01	0.009
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.783739e-01	0.009
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.790564e-01	0.009
Class B/2 (Secretin family receptors)	R-HSA-373080	9.794200e-01	0.009
ROS and RNS production in phagocytes	R-HSA-1222556	9.795772e-01	0.009
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.801726e-01	0.009
RSV-host interactions	R-HSA-9833110	9.802419e-01	0.009
GPVI-mediated activation cascade	R-HSA-114604	9.802630e-01	0.009
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.802630e-01	0.009
Triglyceride catabolism	R-HSA-163560	9.802630e-01	0.009
FGFR2 mutant receptor activation	R-HSA-1839126	9.802630e-01	0.009
Ion channel transport	R-HSA-983712	9.818698e-01	0.008
Voltage gated Potassium channels	R-HSA-1296072	9.819871e-01	0.008
TRAF6 mediated IRF7 activation	R-HSA-933541	9.819871e-01	0.008
Cleavage of the damaged purine	R-HSA-110331	9.819871e-01	0.008
NCAM1 interactions	R-HSA-419037	9.819871e-01	0.008
Collagen chain trimerization	R-HSA-8948216	9.819871e-01	0.008
RNA Polymerase I Promoter Clearance	R-HSA-73854	9.822636e-01	0.008
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.830759e-01	0.007
Translation of Structural Proteins	R-HSA-9694635	9.834766e-01	0.007
Depurination	R-HSA-73927	9.835608e-01	0.007
Purine salvage	R-HSA-74217	9.835608e-01	0.007
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.843280e-01	0.007
Integrin cell surface interactions	R-HSA-216083	9.846100e-01	0.007
Cholesterol biosynthesis	R-HSA-191273	9.846100e-01	0.007
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	9.849970e-01	0.007
Pentose phosphate pathway	R-HSA-71336	9.849970e-01	0.007
Developmental Cell Lineages	R-HSA-9734767	9.851286e-01	0.007
Potential therapeutics for SARS	R-HSA-9679191	9.853848e-01	0.006
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.855147e-01	0.006
Signaling by Retinoic Acid	R-HSA-5362517	9.855147e-01	0.006
SARS-CoV Infections	R-HSA-9679506	9.859898e-01	0.006
Nuclear signaling by ERBB4	R-HSA-1251985	9.863078e-01	0.006
Tryptophan catabolism	R-HSA-71240	9.863078e-01	0.006
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.863078e-01	0.006
Collagen degradation	R-HSA-1442490	9.866137e-01	0.006
Nucleotide salvage	R-HSA-8956321	9.866137e-01	0.006
Maturation of spike protein	R-HSA-9694548	9.875042e-01	0.005
Mitochondrial protein import	R-HSA-1268020	9.876314e-01	0.005
NCAM signaling for neurite out-growth	R-HSA-375165	9.876314e-01	0.005
Potassium Channels	R-HSA-1296071	9.878382e-01	0.005
Scavenging by Class A Receptors	R-HSA-3000480	9.885961e-01	0.005
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	9.885961e-01	0.005
Translation of Structural Proteins	R-HSA-9683701	9.885961e-01	0.005
Platelet degranulation	R-HSA-114608	9.891283e-01	0.005
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	9.894455e-01	0.005
RNA Polymerase I Transcription Initiation	R-HSA-73762	9.895927e-01	0.005
Cleavage of the damaged pyrimidine	R-HSA-110329	9.895927e-01	0.005
Depyrimidination	R-HSA-73928	9.895927e-01	0.005
Signaling by SCF-KIT	R-HSA-1433557	9.905022e-01	0.004
Interferon gamma signaling	R-HSA-877300	9.910611e-01	0.004
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.913323e-01	0.004
DAP12 interactions	R-HSA-2172127	9.913323e-01	0.004
Amine ligand-binding receptors	R-HSA-375280	9.913323e-01	0.004
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.919540e-01	0.004
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.923283e-01	0.003
Pyruvate metabolism	R-HSA-70268	9.925204e-01	0.003
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.928804e-01	0.003
ECM proteoglycans	R-HSA-3000178	9.939695e-01	0.003
Metabolism of cofactors	R-HSA-8978934	9.939695e-01	0.003
Plasma lipoprotein remodeling	R-HSA-8963899	9.939882e-01	0.003
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.940224e-01	0.003
Purine catabolism	R-HSA-74259	9.944359e-01	0.002
Protein localization	R-HSA-9609507	9.949365e-01	0.002
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.949934e-01	0.002
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.951904e-01	0.002
Signaling by ERBB4	R-HSA-1236394	9.952652e-01	0.002
Complex IV assembly	R-HSA-9864848	9.954312e-01	0.002
Cytosolic sulfonation of small molecules	R-HSA-156584	9.954312e-01	0.002
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.955341e-01	0.002
Transcriptional Regulation by NPAS4	R-HSA-9634815	9.958307e-01	0.002
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	9.958307e-01	0.002
Collagen formation	R-HSA-1474290	9.958540e-01	0.002
G alpha (q) signalling events	R-HSA-416476	9.961751e-01	0.002
Amino acids regulate mTORC1	R-HSA-9639288	9.961953e-01	0.002
Adaptive Immune System	R-HSA-1280218	9.965187e-01	0.002
Base-Excision Repair, AP Site Formation	R-HSA-73929	9.965280e-01	0.002
Cell surface interactions at the vascular wall	R-HSA-202733	9.967047e-01	0.001
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.968436e-01	0.001
Metabolism of amine-derived hormones	R-HSA-209776	9.971087e-01	0.001
Neuronal System	R-HSA-112316	9.971595e-01	0.001
Amyloid fiber formation	R-HSA-977225	9.973184e-01	0.001
Extracellular matrix organization	R-HSA-1474244	9.974487e-01	0.001
Triglyceride metabolism	R-HSA-8979227	9.978030e-01	0.001
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.981027e-01	0.001
Transport to the Golgi and subsequent modification	R-HSA-948021	9.981952e-01	0.001
Signaling by PDGF	R-HSA-186797	9.983307e-01	0.001
Leishmania infection	R-HSA-9658195	9.983709e-01	0.001
Parasitic Infection Pathways	R-HSA-9824443	9.983709e-01	0.001
C-type lectin receptors (CLRs)	R-HSA-5621481	9.984139e-01	0.001
Antimicrobial peptides	R-HSA-6803157	9.990163e-01	0.000
FCERI mediated NF-kB activation	R-HSA-2871837	9.990214e-01	0.000
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.991977e-01	0.000
Phospholipid metabolism	R-HSA-1483257	9.992158e-01	0.000
Cardiac conduction	R-HSA-5576891	9.992636e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.993155e-01	0.000
Diseases of carbohydrate metabolism	R-HSA-5663084	9.993905e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.993922e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.994855e-01	0.000
Iron uptake and transport	R-HSA-917937	9.994925e-01	0.000
G alpha (s) signalling events	R-HSA-418555	9.994940e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.995267e-01	0.000
SLC-mediated transport of organic anions	R-HSA-9955298	9.996145e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.996612e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.997410e-01	0.000
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.997999e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.998118e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.998270e-01	0.000
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.999042e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.999192e-01	0.000
Mitochondrial protein degradation	R-HSA-9837999	9.999260e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999448e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999548e-01	0.000
Formation of the cornified envelope	R-HSA-6809371	9.999554e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.999733e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.999752e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999752e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.999896e-01	0.000
Immune System	R-HSA-168256	9.999907e-01	0.000
Initial triggering of complement	R-HSA-166663	9.999910e-01	0.000
Interferon alpha/beta signaling	R-HSA-909733	9.999926e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999926e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999927e-01	0.000
Infectious disease	R-HSA-5663205	9.999949e-01	0.000
Innate Immune System	R-HSA-168249	9.999959e-01	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999964e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999966e-01	0.000
Regulation of Complement cascade	R-HSA-977606	9.999970e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.999975e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999978e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999979e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999984e-01	0.000
Sensory perception of taste	R-HSA-9717189	9.999986e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999986e-01	0.000
Asparagine N-linked glycosylation	R-HSA-446203	9.999996e-01	0.000
Post-translational protein modification	R-HSA-597592	9.999996e-01	0.000
Complement cascade	R-HSA-166658	9.999997e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999997e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999998e-01	0.000
Arachidonate metabolism	R-HSA-2142753	9.999998e-01	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.999999e-01	0.000
Bacterial Infection Pathways	R-HSA-9824439	9.999999e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	1.000000e+00	0.000
Sphingolipid metabolism	R-HSA-428157	1.000000e+00	0.000
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000
Disease	R-HSA-1643685	1.000000e+00	0.000
Keratinization	R-HSA-6805567	1.000000e+00	0.000
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000
Drug ADME	R-HSA-9748784	1.000000e+00	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000