ERK5

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A0MZ66	S444	Sugiyama	SHTN1 KIAA1598	RPVNQTARPKTKPESSKGCEsAVDELKGILGtLNKSTSSRs
A5A3E0	S1065	Sugiyama	POTEF A26C1B	ILASLSTFQQMWISKQEyDEsGPsIVHRKCL__________
A6NMY6	S164	Sugiyama	ANXA2P2 ANX2L2 ANX2P2 LPC2B	NRVyKEMYKtDLEKDIIsDtsGDFRKLMVALAKGRRAEDGS
O00115	S70	Sugiyama	DNASE2 DNASE2A DNL2	QYKyLDEssGGWRDGRALINsPEGAVGRSLQPLyRSNTSQL
O00141	S78	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	SGK1 SGK	LKISQPQEPELMNANPsPPPsPsQQINLGPSSNPHAKPSDF
O00151	S130	Sugiyama	PDLIM1 CLIM1 CLP36	PQEVLHIGsAHNRsAMPFtAsPAsSTTARVItNQyNNPAGL
O00151	S133	Sugiyama	PDLIM1 CLIM1 CLP36	VLHIGsAHNRsAMPFtAsPAsSTTARVItNQyNNPAGLyss
O00410	S974	Sugiyama	IPO5 KPNB3 RANBP5	VIQSADSKTKENVNAtENCIsAVGKIMKFKPDCVNVEEVLP
O14497	S363	Sugiyama	ARID1A BAF250 BAF250A C1orf4 OSA1 SMARCF1	AAAAAAASGGAQQRsHHAPMsPGssGGGGQPLARtPQPssP
O14545	S327	Sugiyama	TRAFD1 FLN29	DHQTSCNPSRALPsLNtGsssPRGVEEPDVIFQNFLQQAAS
O14579	S307	Sugiyama	COPE	IKEYQAKENDFDRLVLQyAPsA___________________
O14618	S267	Sugiyama	CCS	DGLTIWEERGRPIAGKGRKEsAQPPAHL_____________
O14908	S258	Sugiyama	GIPC1 C19orf3 GIPC RGS19IP1	tGRGtLRLRsRGPAtVEDLPsAFEEKAIEKVDDLLESYMGI
O15143	S336	Sugiyama	ARPC1B ARC41	AAGAGLDsLHKNsVsQIsVLsGGKAKCSQFCTTGMDGGMSI
O15230	S422	Sugiyama	LAMA5 KIAA0533 KIAA1907	GVNCERCLPGFYRSPNHPLDsPHVCRRCNCESDFTDGtCED
O43175	S251	Sugiyama	PHGDH PGDH3	VVNCARGGIVDEGALLRALQsGQCAGAALDVFTEEPPRDRA
O43707	T249	Sugiyama	ACTN4	EVAEKyLDIPKMLDAEDIVNtARPDEKAIMTyVssFyHAFs
O43707	T443	Sugiyama	ACTN4	sIHEAWtDGKEAMLKHRDyEtAtLsDIKALIRKHEAFEsDL
O43852	T65	Sugiyama	CALU	FDyDHDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKD
O60361	S107	Sugiyama	NME2P1	GtIRGDFCIQVGRNIIHGsDsVKsAEKEISLRFKPEELVDY
O60361	S110	Sugiyama	NME2P1	RGDFCIQVGRNIIHGsDsVKsAEKEISLRFKPEELVDYKSC
O60664	S76	Sugiyama	PLIN3 M6PRBP1 TIP47	IKTVCDAAEKGVRtLTAAAVsGAQPILSKLEPQIAsAsEyA
O60664	S91	Sugiyama	PLIN3 M6PRBP1 TIP47	TAAAVsGAQPILSKLEPQIAsAsEyAHRGLDKLEENLPILQ
O60664	S93	Sugiyama	PLIN3 M6PRBP1 TIP47	AAVsGAQPILSKLEPQIAsAsEyAHRGLDKLEENLPILQQP
O60664	T69	Sugiyama	PLIN3 M6PRBP1 TIP47	TKESYPHIKTVCDAAEKGVRtLTAAAVsGAQPILSKLEPQI
O60749	S119	Sugiyama	SNX2 TRG9	AVtPVtPttLIAPRIESKsMsAPVIFDRsREEIEEEANGDI
O75347	S103	Sugiyama	TBCA	ENEKDLEEAEEyKEARLVLDsVKLEA_______________
O75821	S189	Sugiyama	EIF3G EIF3S4	CPYKDtLGPMQKELAEQLGLstGEKEKLPGELEPVQAtQNK
O95067	S392	Sugiyama	CCNB2	KLLKISMIPQLNSKAVKDLAsPLIGRs______________
O95218	S65	Sugiyama	ZRANB2 ZIS ZNF265	MKAGGtEIGKtLAEKSRGLFsANDWQCKTCsNVNWARRsEC
O95757	S587	Sugiyama	HSPA4L APG1 HSPH3 OSP94	RLNQTLKKGKVKsIDLPIQssLCRQLGQDLLNsyIENEGKM
O95831	S519	Sugiyama	AIFM1 AIF PDCD8	DSSLPTVGVFAKATAQDNPKsAtEQsGtGIRSESETESEAS
P00338	S161	Sugiyama	LDHA PIG19	DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00338	S167	Sugiyama	LDHA PIG19	AWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVHPLSCHG
P00338	S237	Sugiyama	LDHA PIG19	DLGtDKDKEQWKEVHKQVVEsAyEVIKLKGYtSWAIGLSVA
P00338	S319	Sugiyama	LDHA PIG19	GISDLVKVTLtsEEEARLKKsADtLWGIQKELQF_______
P00338	T322	Sugiyama	LDHA PIG19	DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P00338	T95	Sugiyama	LDHA PIG19	PKIVSGKDyNVTANsKLVIItAGARQQEGEsRLNLVQRNVN
P00558	T376	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	MDEVVKAtsRGCItIIGGGDtAtCCAKWNtEDKVsHVstGG
P00558	T378	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	EVVKAtsRGCItIIGGGDtAtCCAKWNtEDKVsHVstGGGA
P01100	S32	EPSD\|PSP	FOS G0S7	ASSSRCSSASPAGDSLSYyHsPADSFSSMGSPVNAQDFCTD
P01100	T232	EPSD\|PSP	FOS G0S7	FPEEMSVASLDLTGGLPEVAtPESEEAFTLPLLNDPEPKPS
P01106	S77	PSP	MYC BHLHE39	PPAPSEDIWKKFELLPtPPLsPsRRsGLCsPSyVAVTPFsL
P03973	T78	Sugiyama	SLPI WAP4 WFDC4	PGKKRCCPDTCGIKCLDPVDtPNPTRRKPGKCPVTYGQCLM
P04040	S515	Sugiyama	CAT	ALLDKYNAEKPKNAIHtFVQsGsHLAAREKANL________
P04040	T29	Sugiyama	CAT	SDQMQHWKEQRAAQKADVLttGAGNPVGDKLNVItVGPRGP
P04040	T511	Sugiyama	CAT	SHIQALLDKYNAEKPKNAIHtFVQsGsHLAAREKANL____
P04075	S36	Sugiyama	ALDOA ALDA	LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075	T37	Sugiyama	ALDOA ALDA	sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04075	T49	Sugiyama	ALDOA ALDA	GILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtADDR
P04083	S173	Sugiyama	ANXA1 ANX1 LPC1	NRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRsEDFG
P04181	T39	Sugiyama	OAT	HSSVASATSVATKKtVQGPPtSDDIFEREyKyGAHNyHPLP
P04406	T211	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	PsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtGM
P04406	T237	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04792	S83	Sugiyama	HSPB1 HSP27 HSP28	IEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNH
P05787	S404	Sugiyama	KRT8 CYK8	LDIEIATYRKLLEGEESRLEsGMQNMsIHtKTTSGYAGGLS
P06733	S27	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P06733	S37	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	NPtVEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRY
P06733	S40	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	VEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGK
P06733	T19	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	__MSILKIHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGA
P06733	T26	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	IHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEA
P06733	T41	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	EVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKG
P06744	T224	Sugiyama	GPI	SLFIIASKTFTTQEtITNAEtAKEWFLQAAKDPSAVAKHFV
P07195	S162	Sugiyama	LDHB	DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195	S168	Sugiyama	LDHB	TWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIHPSSCHG
P07195	S303	Sugiyama	LDHB	GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195	T302	Sugiyama	LDHB	YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07195	T323	Sugiyama	LDHB	sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07195	T96	Sugiyama	LDHB	PKIVADKDysVtANSKIVVVtAGVRQQEGEsRLNLVQRNVN
P07237	S427	Sugiyama	P4HB ERBA2L PDI PDIA1 PO4DB	WDKLGEtyKDHENIVIAKMDstANEVEAVKVHsFPtLKFFP
P07237	S449	Sugiyama	P4HB ERBA2L PDI PDIA1 PO4DB	ANEVEAVKVHsFPtLKFFPAsADRtVIDyNGERtLDGFKKF
P07355	S164	Sugiyama	ANXA2 ANX2 ANX2L4 CAL1H LPC2D	NRVyKEMYKtDLEKDIIsDtsGDFRKLMVALAKGRRAEDGs
P07437	S75	Sugiyama	TUBB TUBB5 OK/SW-cl.56	tGGKyVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
P07437	T55	Sugiyama	TUBB TUBB5 OK/SW-cl.56	tyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEPGtMDs
P07737	T65	Sugiyama	PFN1	PAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQDGEFs
P07814	S880	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	LKAQYKEKTGKEyIPGQPPLsQssDssPtRNsEPAGLEtPE
P07814	T746	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	NETSAPFKERPtPsLNNNCttsEDsLVLyNRVAVQGDVVRE
P07864	S161	Sugiyama	LDHC LDH3 LDHX	DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07864	S167	Sugiyama	LDHC LDH3 LDHX	VWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVHPTSCHG
P07900	S50	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	MSLIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKL
P07900	S505	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	KENQKHIyyItGETKDQVANsAFVERLRKHGLEVIyMIEPI
P07900	S52	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P08174	S106	Sugiyama	CD55 CR DAF	QWSDIEEFCNRSCEVPtRLNsAsLKQPYITQNyFPVGtVVE
P08174	T102	Sugiyama	CD55 CR DAF	LKGSQWSDIEEFCNRSCEVPtRLNsAsLKQPYITQNyFPVG
P08195	S296	Sugiyama	SLC3A2 MDU1	DLLQIDPNFGsKEDFDsLLQsAKKKSIRVILDLTPNYRGEN
P08195	S403	Sugiyama	SLC3A2 MDU1	SDLQQILSLLESNKDLLLtssyLsDsGstGEHtKSLVTQYL
P08195	S598	Sugiyama	SLC3A2 MDU1	LQASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEP
P08195	S607	Sugiyama	SLC3A2 MDU1	ASLPAKADLLLstQPGREEGsPLELERLKLEPHEGLLLRFP
P08238	S45	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238	S468	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238	S497	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	KEtQKsIyyItGEsKEQVANsAFVERVRKRGFEVVyMtEPI
P08238	T467	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	NRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyIt
P08238	Y457	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	LKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMK
P08708	S89	Sugiyama	RPS17 RPS17L	ISIKLQEEERERRDNyVPEVsALDQEIIEVDPDtKEMLKLL
P09104	S37	Sugiyama	ENO2	NPtVEVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRY
P09104	S40	Sugiyama	ENO2	VEVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRYLGK
P09104	T41	Sugiyama	ENO2	EVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRYLGKG
P09382	S63	Sugiyama	LGALS1	CLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVFPFQPG
P09651	Y366	Sugiyama	HNRNPA1 HNRPA1	QyFAKPRNQGGyGGssssssyGsGRRF______________
P09972	S65	Sugiyama	ALDOC ALDC	sQIGVENtEENRRLYRQVLFsADDRVKKCIGGVIFFHETLY
P0CG38	S1065	Sugiyama	POTEI	ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
P0CG39	S1028	Sugiyama	POTEJ	ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
P10809	S175	Sugiyama	HSPD1 HSP60	LKKQsKPVttPEEIAQVAtIsANGDKEIGNIIsDAMKKVGR
P10809	S225	Sugiyama	HSPD1 HSP60	KtLNDELEIIEGMKFDRGyIsPyFINtsKGQKCEFQDAyVL
P10809	S70	Sugiyama	HSPD1 HSP60	AVAVTMGPKGRtVIIEQsWGsPKVTKDGVtVAKsIDLKDKY
P10809	T164	Sugiyama	HSPD1 HSP60	VMLAVDAVIAELKKQsKPVttPEEIAQVAtIsANGDKEIGN
P10809	T231	Sugiyama	HSPD1 HSP60	LEIIEGMKFDRGyIsPyFINtsKGQKCEFQDAyVLLsEKKI
P10809	Y227	Sugiyama	HSPD1 HSP60	LNDELEIIEGMKFDRGyIsPyFINtsKGQKCEFQDAyVLLs
P11142	S40	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142	T222	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	GGTFDVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFI
P11142	T38	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P11142	T45	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtN
P11142	Y41	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P11586	T128	Sugiyama	MTHFD1 MTHFC MTHFD	SINTEEVINAIAPEKDVDGLtsINAGKLARGDLNDCFIPCt
P12268	S159	Sugiyama	IMPDH2 IMPD2	FCGIPITDtGRMGSRLVGIIssRDIDFLKEEEHDCFLEEIM
P12270	S2155	Sugiyama	TPR	PstPtLVVPHRtDGFAEAIHsPQVAGVPRFRFGPPEDMPQT
P12277	S163	Sugiyama	CKB CKBB	PPHCsRGERRAIEKLAVEALssLDGDLAGRyyALKsMtEAE
P13489	S208	Sugiyama	RNH1 PRI RNH	RVLCQGLKDSPCQLEALKLEsCGVTSDNCRDLCGIVAsKAS
P13639	S593	Sugiyama	EEF2 EF2	SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13639	T735	Sugiyama	EEF2 EF2	HRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQCPEQV
P13667	S383	Sugiyama	PDIA4 ERP70 ERP72	FQSKYEPRSHMMDVQGstQDsAIKDFVLKyALPLVGHRKVS
P13798	S185	Sugiyama	APEH D3F15S2 D3S48E DNF15S2	VAEKKRPKAEsFFQTKALDVsAsDDEIARLKKPDQAIKGDQ
P13929	S14	Sugiyama	ENO3	_______MAMQKIFAREILDsRGNPtVEVDLHtAKGRFRAA
P13929	S37	Sugiyama	ENO3	NPtVEVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRY
P13929	S40	Sugiyama	ENO3	VEVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRYLGK
P13929	T26	Sugiyama	ENO3	IFAREILDsRGNPtVEVDLHtAKGRFRAAVPsGAstGIyEA
P13929	T41	Sugiyama	ENO3	EVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRYLGKG
P14314	T115	Sugiyama	PRKCSH G19P1	GVCDCCDGtDEyNsGVICENtCKEKGRKEREsLQQMAEVtR
P14314	T469	Sugiyama	PRKCSH G19P1	WGsWIGPDHDKFSAMKyEQGtGCWQGPNRstTVRLLCGKEt
P14618	S37	Sugiyama	PKM OIP3 PK2 PK3 PKM2	QLHAAMADTFLEHMCRLDIDsPPItARNtGIICtIGPAsRs
P14618	T41	Sugiyama	PKM OIP3 PK2 PK3 PKM2	AMADTFLEHMCRLDIDsPPItARNtGIICtIGPAsRsVEtL
P14625	S106	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14921	T38	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	ETS1 EWSR2	KVDLELFPsPDMECADVPLLtPSsKEMMSQALKATFSGFTK
P15311	S535	Sugiyama	EZR VIL2	EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15311	T533	Sugiyama	EZR VIL2	NEEKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDII
P15531	S125	Sugiyama	NME1 NDPKA NM23	RGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDyTsC
P15559	S82	Sugiyama	NQO1 DIA4 NMOR1	DPANFQYPAESVLAYKEGHLsPDIVAEQKKLEAADLVIFQF
P15880	S206	Sugiyama	RPS2 RPS4	GRCGsVLVRLIPAPRGtGIVsAPVPKKLLMMAGIDDCytsA
P16278	S433	Sugiyama	GLB1 ELNR1	YGFVLYRTTLPQDCSNPAPLssPLNGVHDRAyVAVDGIPQG
P17066	T224	Sugiyama	HSPA6 HSP70B'	GGTFDVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFM
P17302	S255	SIGNOR\|iPTMNet	GJA1 GJAL	GVKDRVKGKSDPyHATsGALsPAKDCGsQKyAyFNGCssPt
P17302	S282	iPTMNet	GJA1 GJAL	sQKyAyFNGCssPtAPLsPMsPPGyKLVTGDRNNssCRNYN
P17812	S575	Sugiyama	CTPS1 CTPS	LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P17987	S551	Sugiyama	TCP1 CCT1 CCTA	IKLHPESKDDKHGsyEDAVHsGALND_______________
P18669	S152	Sugiyama	PGAM1 PGAMA CDABP0006	FysNIsKDRRyADLtEDQLPsCEsLKDtIARALPFWNEEIV
P18669	S31	Sugiyama	PGAM1 PGAMA CDABP0006	HGEsAWNLENRFsGWyDADLsPAGHEEAKRGGQALRDAGyE
P18754	S125	Sugiyama	RCC1 CHC1	VEGSEMVPGKVELQEKVVQVsAGDsHtAALTDDGRVFLWGS
P18754	T131	Sugiyama	RCC1 CHC1	VPGKVELQEKVVQVsAGDsHtAALTDDGRVFLWGSFRDNNG
P19793	S260	iPTMNet	RXRA NR2B1	LAVEPKTETyVEANMGLNPssPNDPVtNICQAADKQLFTLV
P19793	T82	iPTMNet	RXRA NR2B1	GPPFsVISSPMGPHSMsVPTtPTLGFSTGSPQLSSPMNPVS
P20073	S393	Sugiyama	ANXA7 ANX7 SNX OK/SW-cl.95	FPQLRATMEAYSRMANRDLLsSVSREFSGYVESGLKTILQC
P21333	S1459	Sugiyama	FLNA FLN FLN1	KVPVHDVTDASKVKCsGPGLsPGMVRANLPQsFQVDTSKAG
P22234	S27	Sugiyama	PAICS ADE2 AIRC PAIS	LNIGKKLYEGKtKEVyELLDsPGKVLLQsKDQItAGNAARK
P22314	S816	Sugiyama	UBA1 A1S9T UBE1	VPEFtPKsGVKIHVsDQELQsANAsVDDsRLEELKATLPsP
P22314	T233	Sugiyama	UBA1 A1S9T UBE1	GEQPLSAMVSMVTKDNPGVVtCLDEARHGFESGDFVSFSEV
P22392	S122	Sugiyama	NME2 NM23B	GtIRGDFCIQVGRNIIHGsDsVKsAEKEISLWFKPEELVDy
P22392	S125	Sugiyama	NME2 NM23B	RGDFCIQVGRNIIHGsDsVKsAEKEISLWFKPEELVDyKSC
P22626	S225	Sugiyama	HNRNPA2B1 HNRPA2B1	GNFGFGDsRGGGGNFGPGPGsNFRGGsDGyGsGRGFGDGyN
P23381	S351	Sugiyama	WARS1 IFI53 WARS WRS	KPALLHSTFFPALQGAQTKMsAsDPNssIFLtDtAKQIKTK
P23396	S35	Sugiyama	RPS3 OK/SW-cl.26	GIFKAELNEFLtRELAEDGysGVEVRVtPTRTEIIILATRT
P23396	T220	Sugiyama	RPS3 OK/SW-cl.26	PKKPLPDHVsIVEPKDEILPttPIsEQKGGKPEPPAMPQPV
P23396	T221	Sugiyama	RPS3 OK/SW-cl.26	KKPLPDHVsIVEPKDEILPttPIsEQKGGKPEPPAMPQPVP
P23396	T242	Sugiyama	RPS3 OK/SW-cl.26	PIsEQKGGKPEPPAMPQPVPtA___________________
P23588	S122	Sugiyama	EIF4B	NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P23588	T75	Sugiyama	EIF4B	WHsNDDDVYRAPPIDRsILPtAPRAAREPNIDRSRLPKsPP
P24534	S8	Sugiyama	EEF1B2 EEF1B EF1B	_____________MGFGDLKsPAGLQVLNDyLADKSYIEGY
P25786	S14	Sugiyama	PSMA1 HC2 NU PROS30 PSC2	_______MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQGSA
P25815	S47	Sugiyama	S100P S100E	tLTKGELKVLMEKELPGFLQsGKDKDAVDKLLKDLDANGDA
P26232	S667	Sugiyama	CTNNA2 CAPR	YDVRsRtsVQtEDDQLIAGQsARAIMAQLPQEEKAKIAEQV
P26373	T148	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373	T151	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P26640	T47	Sugiyama	VARS1 G7A VARS VARS2	AGEGPGWGGAHPRICLQPPPtSRTPFPPPRLPALEQGPGGL
P27797	S52	Sugiyama	CALR CRTC	GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27824	S362	Sugiyama	CANX	WDEDMDGEWEAPQIANPRCEsAPGCGVWQRPVIDNPNyKGK
P28066	S172	Sugiyama	PSMA5	QLFHMDPsGtFVQCDARAIGsAsEGAQssLQEVyHKSMTLK
P28066	S179	Sugiyama	PSMA5	sGtFVQCDARAIGsAsEGAQssLQEVyHKSMTLKEAIKSSL
P28074	S175	Sugiyama	PSMB5 LMPX MB1 X	SMGTMICGWDKRGPGLyyVDsEGNRISGATFSVGSGSVYAY
P29144	S93	Sugiyama	TPP2	SGDVNTATEVEPKDGEIVGLsGRVLKIPASWTNPSGKYHIG
P29401	S548	Sugiyama	TKT	NIRVLDPFTIKPLDRKLILDsARAtKGRILTVEDHYYEGGI
P29401	T442	Sugiyama	TKT	GEDGPSQMALEDLAMFRsVPtstVFyPsDGVAtEKAVELAA
P29590	S403	EPSD\|PSP	PML MYL PP8675 RNF71 TRIM19	LQDLSSCITQGKDAAVSKKAsPEAAstPRDPIDVDLPEEAE
P29590	T409	EPSD\|PSP	PML MYL PP8675 RNF71 TRIM19	CITQGKDAAVSKKAsPEAAstPRDPIDVDLPEEAERVKAQV
P29692	S64	Sugiyama	EEF1D EF1D	sVILRDIARARENIQKsLAGssGPGAssGtsGDHGELVVRI
P29692	S65	Sugiyama	EEF1D EF1D	VILRDIARARENIQKsLAGssGPGAssGtsGDHGELVVRIA
P29692	S74	Sugiyama	EEF1D EF1D	RENIQKsLAGssGPGAssGtsGDHGELVVRIAsLEVENQsL
P29692	T73	Sugiyama	EEF1D EF1D	ARENIQKsLAGssGPGAssGtsGDHGELVVRIAsLEVENQs
P29966	S26	Sugiyama	MARCKS MACS PRKCSL	SKTAAKGEAAAERPGEAAVAssPsKANGQENGHVKVNGDAs
P30041	T44	Sugiyama	PRDX6 AOP2 KIAA0106	RFHDFLGDSWGILFSHPRDFtPVCttELGRAAKLAPEFAKR
P30041	T48	Sugiyama	PRDX6 AOP2 KIAA0106	FLGDSWGILFSHPRDFtPVCttELGRAAKLAPEFAKRNVKL
P30050	S138	Sugiyama	RPL12	HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30050	S157	Sugiyama	RPL12	QsVGCNVDGRHPHDIIDDINsGAVECPAs____________
P30050	S165	Sugiyama	RPL12	GRHPHDIIDDINsGAVECPAs____________________
P30050	S26	Sugiyama	RPL12	DPNEIKVVYLRCtGGEVGAtsALAPKIGPLGLsPKKVGDDI
P30050	T135	Sugiyama	RPL12	QMRHRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDI
P30086	S139	Sugiyama	PEBP1 PBP PEBP	RyVWLVyEQDRPLKCDEPILsNRsGDHRGKFKVAsFRKKyE
P30086	S52	Sugiyama	PEBP1 PBP PEBP	AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P30086	S60	Sugiyama	PEBP1 PBP PEBP	VLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPDAPsRKDPK
P30101	S443	Sugiyama	PDIA3 ERP57 ERP60 GRP58	LsKDPNIVIAKMDAtANDVPsPyEVRGFPtIyFsPANKKLN
P31153	S247	Sugiyama	MAT2A AMS2 MATA2	IKAVVPAKyLDEDtIyHLQPsGRFVIGGPQGDAGLtGRKII
P31327	T45	Sugiyama	CPS1	AHQKWKFSRPGIRLLSVKAQtAHIVLEDGtKMKGYSFGHPS
P31327	T536	Sugiyama	CPS1	CGVELFKRGVLKEYGVKVLGtsVEsIMATEDRQLFSDKLNE
P31943	S104	Sugiyama	HNRNPH1 HNRPH HNRPH1	EVFKSNNVEMDWVLKHtGPNsPDtANDGFVRLRGLPFGCSK
P31943	S269	Sugiyama	HNRNPH1 HNRPH HNRPH1	YNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGstFQsttGH
P31943	T100	Sugiyama	HNRNPH1 HNRPH HNRPH1	HRyVEVFKSNNVEMDWVLKHtGPNsPDtANDGFVRLRGLPF
P31943	T107	Sugiyama	HNRNPH1 HNRPH HNRPH1	KSNNVEMDWVLKHtGPNsPDtANDGFVRLRGLPFGCSKEEI
P31948	S459	Sugiyama	STIP1	EAMKDytKAMDVYQKALDLDssCKEAADGYQRCMMAQyNRH
P31948	T243	Sugiyama	STIP1	KQALKEKELGNDAYKKKDFDtALKHYDKAKELDPtNMtyIT
P33316	S164	Sugiyama	DUT	YTIPPMEKAVVKTDIQIALPsGCyGRVAPRSGLAAKHFIDV
P34897	T432	Sugiyama	SHMT2	CPGDRsAItPGGLRLGAPALtSRQFREDDFRRVVDFIDEGV
P34931	S42	Sugiyama	HSPA1L	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34931	T224	Sugiyama	HSPA1L	GGTFDVSILTIDDGIFEVKAtAGDtHLGGEDFDNRLVsHFV
P34931	T40	Sugiyama	HSPA1L	VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P34931	T47	Sugiyama	HSPA1L	KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQN
P34931	Y43	Sugiyama	HSPA1L	FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P35221	S668	Sugiyama	CTNNA1	FDVRsRtsVQtEDDQLIAGQsARAIMAQLPQEQKAKIAEQV
P35606	S160	Sugiyama	COPB2	GHTHYVMQIVINPKDNNQFAsAsLDRtIKVWQLGsssPNFT
P35606	T828	Sugiyama	COPB2	EEWVKETHADLWPAKQyPLVtPNEERNVMEEGKDFQPSRst
P35613	S277	Sugiyama	BSG UNQ6505/PRO21383	KITDSEDKALMNGSESRFFVsssQGRSELHIENLNMEADPG
P35613	S279	Sugiyama	BSG UNQ6505/PRO21383	TDSEDKALMNGSESRFFVsssQGRSELHIENLNMEADPGQy
P35637	S346	Sugiyama	FUS TLS	TDRETGKLKGEAtVsFDDPPsAKAAIDWFDGKEFsGNPIKV
P37802	S145	Sugiyama	TAGLN2 KIAA0120 CDABP0035	VQRTLMNLGGLAVARDDGLFsGDPNWFPKKSKENPRNFsDN
P37802	T180	Sugiyama	TAGLN2 KIAA0120 CDABP0035	RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P37837	S13	Sugiyama	TALDO1 TAL TALDO TALDOR	________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P38646	T94	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	QAKVLENAEGARttPsVVAFtADGERLVGMPAKRQAVtNPN
P38919	S62	Sugiyama	EIF4A3 DDX48 KIAA0111	TMGLREDLLRGIyAyGFEKPsAIQQRAIKQIIKGRDVIAQS
P40227	S49	Sugiyama	CCT6A CCT6 CCTZ	GLQDVLRTNLGPKGTMKMLVsGAGDIKLTKDGNVLLHEMQI
P40763	S701	Sugiyama	STAT3 APRF	EAFGKyCRPEsQEHPEADPGsAAPyLKTKFICVtPttCsNt
P46060	S453	Sugiyama	RANGAP1 KIAA1835 SD	DVstFLAFPsPEKLLRLGPKssVLIAQQTDTSDPEKVVSAF
P46777	S172	Sugiyama	RPL5 MSTP030	RTTTGNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNA
P46777	S176	Sugiyama	RPL5 MSTP030	GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P46777	S224	Sugiyama	RPL5 MSTP030	VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46783	S146	Sugiyama	RPS10	TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P46937	S403	Sugiyama	YAP1 YAP65	DPFLNsGtyHsRDEstDsGLsMssysVPRtPDDFLNsVDEM
P47756	S90	Sugiyama	CAPZB	SyRsPWSNKyDPPLEDGAMPsARLRKLEVEANNAFDQYRDL
P47914	S142	Sugiyama	RPL29	KAKAKAKAKDQTKAQAAAPAsVPAQAPKRtQAPtKAsE___
P48741	T224	Sugiyama	HSPA7 HSP70B	GGTFDVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFM
P49321	S659	Sugiyama	NASP	IEELKELLPEIREKIEDAKEsQRsGNVAELALKATLVEsst
P49327	S2039	Sugiyama	FASN FAS	FSSVSCGRGNAGQsNyGFANsAMERICEKRRHEGLPGLAVQ
P50542	S317	Sugiyama	PEX5 PXR1	EMAKRDAEAHPWLSDyDDLtsATyDKGYQFEEENPLRDHPQ
P50542	T316	Sugiyama	PEX5 PXR1	EEMAKRDAEAHPWLSDyDDLtsATyDKGYQFEEENPLRDHP
P50991	S166	Sugiyama	CCT4 CCTD SRB	EILTDMSRPVELSDRETLLNsATTSLNSKVVSQYSSLLsPM
P50991	T50	Sugiyama	CCT4 CCTD SRB	PAQIRFsNISAAKAVADAIRtsLGPKGMDKMIQDGKGDVtI
P52594	S368	Sugiyama	AGFG1 HRB RAB RIP	GFGTTGKAPVGsVVsVPsQssAssDKYAALAELDSVFSSAA
P52597	S107	Sugiyama	HNRNPF HNRPF	KSHRTEMDWVLKHsGPNsADsANDGFVRLRGLPFGCTKEEI
P52888	S29	Sugiyama	THOP1	GDMADAAsPCSVVNDLRWDLsAQQIEERTRELIEQTKRVyD
P53365	S260	Sugiyama	ARFIP2 POR1	TDLEELsLGPRDAGTRGRLEsAQATFQAHRDKYEKLRGDVA
P53999	S57	Sugiyama	SUB1 PC4 RPO2TC1	VKKQKTGETsRALsssKQssssRDDNMFQIGKMRYVSVRDF
P54652	S41	Sugiyama	HSPA2	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P54652	T225	Sugiyama	HSPA2	GGTFDVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLA
P54652	T39	Sugiyama	HSPA2	VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P54652	T46	Sugiyama	HSPA2	KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTN
P54652	Y42	Sugiyama	HSPA2	FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P55072	T14	Sugiyama	VCP HEL-220 HEL-S-70	_______MAsGADsKGDDLstAILKQKNRPNRLIVDEAINE
P55795	S104	Sugiyama	HNRNPH2 FTP3 HNRPH2	EVFKSNsVEMDWVLKHtGPNsPDtANDGFVRLRGLPFGCSK
P55795	S269	Sugiyama	HNRNPH2 FTP3 HNRPH2	YNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGssFQstTGH
P55795	T100	Sugiyama	HNRNPH2 FTP3 HNRPH2	HRyVEVFKSNsVEMDWVLKHtGPNsPDtANDGFVRLRGLPF
P55795	T107	Sugiyama	HNRNPH2 FTP3 HNRPH2	KSNsVEMDWVLKHtGPNsPDtANDGFVRLRGLPFGCSKEEI
P55809	S509	Sugiyama	OXCT1 OXCT SCOT	LWEGLTVDDVQKSTGCDFAVsPKLMPMQQIAN_________
P60174	S212	Sugiyama	TPI1 TPI	WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60174	S80	Sugiyama	TPI1 TPI	IAVAAQNCyKVTNGAFtGEIsPGMIKDCGAtWVVLGHsERR
P60174	T214	Sugiyama	TPI1 TPI	KsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGG
P60174	T217	Sugiyama	TPI1 TPI	VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60174	T76	Sugiyama	TPI1 TPI	LDPKIAVAAQNCyKVTNGAFtGEIsPGMIKDCGAtWVVLGH
P60660	T22	Sugiyama	MYL6	CDFTEDQTAEFKEAFQLFDRtGDGKILysQCGDVMRALGQN
P60709	S199	Sugiyama	ACTB	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709	S233	Sugiyama	ACTB	KEKLCyVALDFEQEMAtAAssssLEKsyELPDGQVItIGNE
P60709	S323	Sugiyama	ACTB	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709	S365	Sugiyama	ACTB	ILAsLstFQQMWISKQEyDEsGPsIVHRKCF__________
P60709	S52	Sugiyama	ACTB	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709	S60	Sugiyama	ACTB	HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P60709	T106	Sugiyama	ACTB	WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P60709	T201	Sugiyama	ACTB	AGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVAL
P60709	T203	Sugiyama	ACTB	RDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVALDF
P60709	T229	Sugiyama	ACTB	VRDIKEKLCyVALDFEQEMAtAAssssLEKsyELPDGQVIt
P60709	T318	Sugiyama	ACTB	VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P60709	T324	Sugiyama	ACTB	tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P60709	Y53	Sugiyama	ACTB	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P60842	S56	Sugiyama	EIF4A1 DDX2A EIF4A	DMNLSESLLRGIyAyGFEKPsAIQQRAILPCIKGyDVIAQA
P60842	S78	Sugiyama	EIF4A1 DDX2A EIF4A	IQQRAILPCIKGyDVIAQAQsGtGKTATFAISILQQIELDL
P61221	Y594	Sugiyama	ABCE1 RLI RNASEL1 RNASELI RNS4I OK/SW-cl.40	RPRINKLNsIKDVEQKKsGNyFFLDD_______________
P61247	S236	Sugiyama	RPS3A FTE1 MFTL	KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61247	S238	Sugiyama	RPS3A FTE1 MFTL	LKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGyEP
P61254	T8	Sugiyama	RPL26	_____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P61981	S38	Sugiyama	YWHAG	ERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKNVVGARRS
P62081	S174	Sugiyama	RPS7	IKVHLDKAQQNNVEHKVEtFsGVyKKLTGKDVNFEFPEFQL
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62263	S137	Sugiyama	RPS14 PRO2640	RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62263	T133	Sugiyama	RPS14 PRO2640	QsALRALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL__
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62736	S325	Sugiyama	ACTA2 ACTSA ACTVS GIG46	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736	S54	Sugiyama	ACTA2 ACTSA ACTVS GIG46	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736	S62	Sugiyama	ACTA2 ACTSA ACTVS GIG46	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P62736	T320	Sugiyama	ACTA2 ACTSA ACTVS GIG46	VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P62736	T326	Sugiyama	ACTA2 ACTSA ACTVS GIG46	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62736	Y55	Sugiyama	ACTA2 ACTSA ACTVS GIG46	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62826	T21	Sugiyama	RAN ARA24 OK/SW-cl.81	MAAQGEPQVQFKLVLVGDGGtGKttFVKRHLtGEFEKKyVA
P62826	T66	Sugiyama	RAN ARA24 OK/SW-cl.81	EVHPLVFHTNRGPIKFNVWDtAGQEKFGGLRDGYYIQAQCA
P62899	S15	Sugiyama	RPL31	______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62917	S130	Sugiyama	RPL8	GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62942	S9	Sugiyama	FKBP1A FKBP1 FKBP12	____________MGVQVEtIsPGDGRtFPKRGQtCVVHytG
P62979	S123	Sugiyama	RPS27A UBA80 UBCEP1	LKYYKVDENGKIsRLRRECPsDECGAGVFMAsHFDRHyCGK
P63104	S28	Sugiyama	YWHAZ	QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104	T194	Sugiyama	YWHAZ	FSVFYYEILNsPEKACSLAKtAFDEAIAELDtLsEEsyKDs
P63104	T30	Sugiyama	YWHAZ	AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63173	T14	Sugiyama	RPL38	_______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63261	S199	Sugiyama	ACTG1 ACTG	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261	S233	Sugiyama	ACTG1 ACTG	KEKLCyVALDFEQEMAtAAssssLEKsyELPDGQVItIGNE
P63261	S323	Sugiyama	ACTG1 ACTG	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261	S365	Sugiyama	ACTG1 ACTG	ILAsLstFQQMWISKQEyDEsGPsIVHRKCF__________
P63261	S52	Sugiyama	ACTG1 ACTG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261	S60	Sugiyama	ACTG1 ACTG	HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P63261	T106	Sugiyama	ACTG1 ACTG	WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P63261	T201	Sugiyama	ACTG1 ACTG	AGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVAL
P63261	T203	Sugiyama	ACTG1 ACTG	RDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVALDF
P63261	T229	Sugiyama	ACTG1 ACTG	VRDIKEKLCyVALDFEQEMAtAAssssLEKsyELPDGQVIt
P63261	T318	Sugiyama	ACTG1 ACTG	VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P63261	T324	Sugiyama	ACTG1 ACTG	tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63261	Y53	Sugiyama	ACTG1 ACTG	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267	S324	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267	S53	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267	S61	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P63267	T319	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P63267	T325	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P63267	Y54	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68032	S325	Sugiyama	ACTC1 ACTC	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032	S54	Sugiyama	ACTC1 ACTC	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032	S62	Sugiyama	ACTC1 ACTC	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68032	T320	Sugiyama	ACTC1 ACTC	VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68032	T326	Sugiyama	ACTC1 ACTC	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032	Y55	Sugiyama	ACTC1 ACTC	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68133	S325	Sugiyama	ACTA1 ACTA	TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133	S54	Sugiyama	ACTA1 ACTA	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133	S62	Sugiyama	ACTA1 ACTA	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68133	T320	Sugiyama	ACTA1 ACTA	VMSGGTTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68133	T326	Sugiyama	ACTA1 ACTA	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133	Y55	Sugiyama	ACTA1 ACTA	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68363	T73	Sugiyama	TUBA1B	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363	T80	Sugiyama	TUBA1B	KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
P68363	Y83	Sugiyama	TUBA1B	PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
P78347	S210	Sugiyama	GTF2I BAP135 WBSCR6	EPKKHVGGRVMVtDADRsILsPGGsCGPIKVKTEPTEDSGI
P78371	S143	Sugiyama	CCT2 99D8.1 CCTB	PQTIIAGWREATKAAREALLssAVDHGsDEVKFRQDLMNIA
P78371	S144	Sugiyama	CCT2 99D8.1 CCTB	QTIIAGWREATKAAREALLssAVDHGsDEVKFRQDLMNIAG
P78371	T475	Sugiyama	CCT2 99D8.1 CCTB	GYDSADLVAQLRAAHsEGNttAGLDMREGTIGDMAILGITE
P78417	S13	Sugiyama	GSTO1 GSTTLP28	________MSGESARsLGKGsAPPGPVPEGsIRIySMRFCP
P78527	T2647	Sugiyama	PRKDC HYRC HYRC1	ARWPVAGQIRAtQQQHDFtLtQtADGRssFDWLTGsstDPL
P78527	T2649	Sugiyama	PRKDC HYRC HYRC1	WPVAGQIRAtQQQHDFtLtQtADGRssFDWLTGsstDPLVD
P83731	S38	Sugiyama	RPL24	GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P84098	S12	Sugiyama	RPL19	_________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
P85037	S420	Sugiyama	FOXK1 MNF	RGVSCFRtPFGPLssRsAPAsPtHPGLMsPRsGGLQtPECL
P85037	S428	Sugiyama	FOXK1 MNF	PFGPLssRsAPAsPtHPGLMsPRsGGLQtPECLsREGsPIP
Q00610	S886	Sugiyama	CLTC CLH17 CLTCL2 KIAA0034	IHEGCEEPAtHNALAKIyIDsNNNPERFLRENPyyDsRVVG
Q00613	S307	Sugiyama	HSF1 HSTF1	RPLSSsPLVRVKEEPPsPPQsPRVEEAsPGRPssVDtLLsP
Q00613	S363	Sugiyama	HSF1 HSTF1	AsVTALtDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNE
Q00613	T367	Sugiyama	HSF1 HSTF1	ALtDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNELSDH
Q00613	T369	Sugiyama	HSF1 HSTF1	tDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNELSDHLD
Q01105	S133	Sugiyama	SET	DEEALHYLTRVEVtEFEDIKsGyRIDFyFDENPyFENKVLS
Q01433	S97	Sugiyama	AMPD2	FTRSLAESELRSAPYEFPEEsPIEQLEERRQRLERQISQDV
Q01518	S431	Sugiyama	CAP1 CAP	NKTDGCHAYLSKNSLDCEIVsAKSSEMNVLIPTEGGDFNEF
Q01650	S31	Sugiyama	SLC7A5 CD98LC LAT1 MPE16	LAAPAAEEKEEAREKMLAAKsADGsAPAGEGEGVtLQRNIT
Q02078	S355	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	MEF2A MEF2	AYNTDYSLTSADLSALQGFNsPGMLSLGQVSAWQQHHLGQA
Q02078	T312	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	MEF2A MEF2	EELELNTQRISSSQATQPLAtPVVSVTtPSLPPQGLVYSAM
Q02078	T319	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	MEF2A MEF2	QRISSSQATQPLAtPVVSVTtPSLPPQGLVYSAMPTAYNTD
Q02790	S15	Sugiyama	FKBP4 FKBP52	______MTAEEMKAtEsGAQsAPLPMEGVDIsPKQDEGVLK
Q02952	S364	Sugiyama	AKAP12 AKAP250	EVAsEKLtAsEQAHPQEPAEsAHEPRLsAEyEKVELPsEEQ
Q04637	S198	Sugiyama	EIF4G1 EIF4F EIF4G EIF4GI	KTIRIRDPNQGGKDITEEIMsGARtAstPtPPQtGGGLEPQ
Q04721	S838	Sugiyama	NOTCH2	TCHCVLPYTGKNCQTVLAPCsPNPCENAAVCKESPNFESYT
Q06413	S387	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD	MEF2C	GACTSTHLSQSSNLSLPSTQsLNIKSEPVsPPRDRTTtPSR
Q06413	S419	GPS6	MEF2C	RDRTTtPSRYPQHTRHEAGRsPVDSLSSCSSSYDGSDREDH
Q09666	S93	Sugiyama	AHNAK PM227	LLNTMGHHTVGLKLHRKGDRsPEPGQtWtREVFssCssEVV
Q12802	S1294	Sugiyama	AKAP13 BRX HT31 LBC	EACHMsLssPELGPLTKGLEsAFTEKVSTFPPGESLPMGST
Q12959	S158	EPSD\|PSP	DLG1	sEKNLsEIENVHGFVSHSHIsPIKPTEAVLPSPPTVPVIPV
Q13163	S129	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	MAP2K5 MEK5 MKK5 PRKMK5	CKPPGERNIHGLKVNtRAGPsQHssPAVsDsLPsNsLKKss
Q13163	S137	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	MAP2K5 MEK5 MKK5 PRKMK5	IHGLKVNtRAGPsQHssPAVsDsLPsNsLKKssAELKKILA
Q13163	S142	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	MAP2K5 MEK5 MKK5 PRKMK5	VNtRAGPsQHssPAVsDsLPsNsLKKssAELKKILANGQMN
Q13163	S149	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	MAP2K5 MEK5 MKK5 PRKMK5	sQHssPAVsDsLPsNsLKKssAELKKILANGQMNEQDIRYR
Q13164	S14	Sugiyama	MAPK7 BMK1 ERK5 PRKM7	_______MAEPLKEEDGEDGsAEPPGPVKAEPAHtAASVAA
Q13164	S175	Sugiyama	MAPK7 BMK1 ERK5 PRKM7	TLEHVRYFLYQLLRGLKyMHsAQVIHRDLKPSNLLVNENCE
Q13164	S210	Sugiyama	MAPK7 BMK1 ERK5 PRKM7	VNENCELKIGDFGMARGLCtsPAEHQYFMtEyVAtRWYRAP
Q13164	S337	Sugiyama	MAPK7 BMK1 ERK5 PRKM7	DRQALSLLGRMLRFEPSARIsAAAALRHPFLAKYHDPDDEP
Q13164	S421	EPSD\|PSP	MAPK7 BMK1 ERK5 PRKM7	FQPSLQPVASEPGCPDVEMPsPWAPSGDCAMEsPPPAPPPC
Q13164	S433	EPSD\|PSP	MAPK7 BMK1 ERK5 PRKM7	GCPDVEMPsPWAPSGDCAMEsPPPAPPPCPGPAPDTIDLTL
Q13164	S496	EPSD\|PSP	MAPK7 BMK1 ERK5 PRKM7	KAALKAALLKSLRSRLRDGPsAPLEAPEPRKPVTAQERQRE
Q13164	S567	SIGNOR	MAPK7 BMK1 ERK5 PRKM7	ASGGPStDPLAGLVLsDNDRsLLERWTRMARPAAPALTSVP
Q13164	S731	SIGNOR\|EPSD\|PSP	MAPK7 BMK1 ERK5 PRKM7	NLVTQQLSKsQVEDPLPPVFsGtPKGSGAGYGVGFDLEEFL
Q13164	S770	EPSD\|PSP	MAPK7 BMK1 ERK5 PRKM7	FLNQsFDMGVADGPQDGQADsAsLsASLLADWLEGHGMNPA
Q13164	S772	EPSD\|PSP	MAPK7 BMK1 ERK5 PRKM7	NQsFDMGVADGPQDGQADsAsLsASLLADWLEGHGMNPADI
Q13164	S774	EPSD\|PSP	MAPK7 BMK1 ERK5 PRKM7	sFDMGVADGPQDGQADsAsLsASLLADWLEGHGMNPADIES
Q13164	S803	SIGNOR	MAPK7 BMK1 ERK5 PRKM7	EGHGMNPADIESLQREIQMDsPMLLADLPDLQDP_______
Q13164	T209	Sugiyama	MAPK7 BMK1 ERK5 PRKM7	LVNENCELKIGDFGMARGLCtsPAEHQYFMtEyVAtRWYRA
Q13164	T219	Sugiyama	MAPK7 BMK1 ERK5 PRKM7	GDFGMARGLCtsPAEHQYFMtEyVAtRWYRAPELMLSLHEY
Q13164	T28	EPSD\|PSP	MAPK7 BMK1 ERK5 PRKM7	EDGEDGsAEPPGPVKAEPAHtAASVAAKNLALLKARSFDVT
Q13164	T733	SIGNOR\|EPSD\|PSP	MAPK7 BMK1 ERK5 PRKM7	VTQQLSKsQVEDPLPPVFsGtPKGSGAGYGVGFDLEEFLNQ
Q13164	T77	Sugiyama	MAPK7 BMK1 ERK5 PRKM7	IIETIGNGAYGVVSSARRRLtGQQVAIKKIPNAFDVVTNAK
Q13164	Y172	Sugiyama	MAPK7 BMK1 ERK5 PRKM7	QPLTLEHVRYFLYQLLRGLKyMHsAQVIHRDLKPSNLLVNE
Q13164	Y221	Sugiyama	MAPK7 BMK1 ERK5 PRKM7	FGMARGLCtsPAEHQYFMtEyVAtRWYRAPELMLSLHEYTQ
Q13200	S16	Sugiyama	PSMD2 TRAP2	_____MEEGGRDKAPVQPQQsPAAAPGGtDEKPsGKERRDA
Q13283	S232	Sugiyama	G3BP1 G3BP	EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13509	S75	Sugiyama	TUBB3 TUBB4	SSHKYVPRAILVDLEPGtMDsVRSGAFGHLFRPDNFIFGQS
Q13573	S224	Sugiyama	SNW1 SKIIP SKIP	KDPMEPPRFKINKKIPRGPPsPPAPVMHsPsRKMTVKEQQE
Q13573	S232	Sugiyama	SNW1 SKIIP SKIP	FKINKKIPRGPPsPPAPVMHsPsRKMTVKEQQEWKIPPCIS
Q13610	S65	Sugiyama	PWP1	EEGGGsDEEEtGsPsEDGMQsARTQARPREPLEDGDPEDDR
Q13885	S75	Sugiyama	TUBB2A TUBB2	AGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q14157	S859	Sugiyama	UBAP2L KIAA0144 NICE4	FPtPttPLtGRDGsLAsNPysGDLtKFGRGDASSPAPATTL
Q14160	S504	Sugiyama	SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL	MKRSIEGRRsEACPCQPDsGsPLPAEEEKRLsAESGLSEDS
Q14240	S57	Sugiyama	EIF4A2 DDX2B EIF4F	DMNLKESLLRGIyAyGFEKPsAIQQRAIIPCIKGyDVIAQA
Q14240	S79	Sugiyama	EIF4A2 DDX2B EIF4F	IQQRAIIPCIKGyDVIAQAQsGtGKTATFAISILQQLEIEF
Q14247	S282	Sugiyama	CTTN EMS1	QKDyKTGFGGKFGVQsERQDsAAVGFDyKEKLAKHEsQQDy
Q14247	S405	Sugiyama	CTTN EMS1	EEARRKLEEQARAKtQtPPVsPAPQPtEERLPssPVyEDAA
Q14247	S438	Sugiyama	CTTN EMS1	sPVyEDAAsFKAELsyRGPVsGtEPEPVysMEAADyREASS
Q14444	T303	Sugiyama	CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105	YTEQSEVESTEYVNRQFMAEtQFtsGEKEQVDEWTVETVEV
Q14444	T306	Sugiyama	CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105	QSEVESTEYVNRQFMAEtQFtsGEKEQVDEWTVETVEVVNS
Q14498	S334	Sugiyama	RBM39 HCC1 RNPC2	FELAGRPMKVGHVTERtDAssAssFLDsDELERtGIDLGtT
Q14568	S50	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	MSLIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKL
Q14568	S52	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14814	S180	GPS6\|SIGNOR\|iPTMNet	MEF2D	SGSLVTPSLVTSSLTDPRLLsPQQPALQRNsVsPGLPQRPA
Q14934	S168	GPS6\|EPSD	NFATC4 NFAT3	PPEGFGGYREAGGQGGGAFFsPsPGSSSLSSWSFFSDASDE
Q14934	S170	GPS6\|EPSD	NFATC4 NFAT3	EGFGGYREAGGQGGGAFFsPsPGSSSLSSWSFFSDASDEAA
Q14980	S1187	Sugiyama	NUMA1 NMP22 NUMA	LQGQLEEKAQELGHsQsALAsAQRELAAFRTKVQDHSKAED
Q14980	S1757	Sugiyama	NUMA1 NMP22 NUMA	ITSKLPRtQPDGtsVPGEPAsPIsQRLPPKVEsLEsLyFtP
Q15181	S250	Sugiyama	PPA1 IOPPP PP	LVTKKTNGKGIsCMNttLsEsPFKCDPDAARAIVDALPPPC
Q15181	T245	Sugiyama	PPA1 IOPPP PP	DHWKALVTKKTNGKGIsCMNttLsEsPFKCDPDAARAIVDA
Q15293	T76	Sugiyama	RCN1 RCN	FQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGD
Q15773	S238	Sugiyama	MLF2	GAGGRRAEGPPRLAIQGPEDsPsRQsRRYDW__________
Q16204	S244	Sugiyama	CCDC6 D10S170 TST1	LEAEKRILQEKLDQPVsAPPsPRDIsMEIDsPENMMRHIRF
Q16543	T370	Sugiyama	CDC37 CDC37A	EAKEGEEAGPGDPLLEAVPKtGDEKDVsV____________
Q16630	T404	Sugiyama	CPSF6 CFIM68	yGRPPPYDRGDyGPPGREMDtARtPLsEAEFEEIMNRNRAI
Q16719	S460	Sugiyama	KYNU	LyNsFHDVyKFTNLLtsILDsAETKN_______________
Q16719	T455	Sugiyama	KYNU	VAPVPLyNsFHDVyKFTNLLtsILDsAETKN__________
Q16762	S202	Sugiyama	TST	SRSQGRFLGTEPEPDAVGLDsGHIRGAVNMPFMDFLTEDGF
Q53EL6	S94	Sugiyama	PDCD4 H731	GDsVsDsGsDALRSGLtVPtsPKGRLLDRRSRSGKGRGLPK
Q58FF7	S370	Sugiyama	HSP90AB3P HSP90BC	KETQKSTYYITGESKEQVANsAFVERVRKQGFEVVYMTEPI
Q5JTZ9	S466	Sugiyama	AARS2 AARSL KIAA1270	LGLPLDMVELMLEEKGVQLDsAGLERLAQEEAQHRARQAEP
Q5T4S7	S178	Sugiyama	UBR4 KIAA0462 KIAA1307 RBAF600	AKLPQTVKTLSDVEDQKELAsPVsPELRQKEVQMNFLNQLT
Q5T4S7	S181	Sugiyama	UBR4 KIAA0462 KIAA1307 RBAF600	PQTVKTLSDVEDQKELAsPVsPELRQKEVQMNFLNQLTSVF
Q5T5Y3	S1152	Sugiyama	CAMSAP1	HLRPFPAssHPRtPtDPGLDsALEPSGDPHGKCLFDSYRLH
Q6PKG0	S774	Sugiyama	LARP1 KIAA0731 LARP	LFGAPEPstIARsLPttVPEsPNyRNtRtPRtPRtPQLKDS
Q6S8J3	S1065	Sugiyama	POTEE A26C1A POTE2	ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
Q6S8J3	S933	Sugiyama	POTEE A26C1A POTE2	KEKLCyVALDFEQEMAtAAssssLEKsyELPDGQVItIGNE
Q6S8J3	T929	Sugiyama	POTEE A26C1A POTE2	VRDIKEKLCyVALDFEQEMAtAAssssLEKsyELPDGQVIt
Q6ZMR3	S161	Sugiyama	LDHAL6A LDHL2	DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q6ZMR3	S167	Sugiyama	LDHAL6A LDHL2	AWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIHSESCHG
Q71U36	T73	Sugiyama	TUBA1A TUBA3	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36	T80	Sugiyama	TUBA1A TUBA3	KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q71U36	Y83	Sugiyama	TUBA1A TUBA3	PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q7L2J0	S217	Sugiyama	MEPCE BCDIN3	LNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPKDItD
Q7L2J0	T213	Sugiyama	MEPCE BCDIN3	DPLNLNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPK
Q7Z417	S692	Sugiyama	NUFIP2 KIAA1321 PIG1	IWNLQKQDPKRIItyNEAMDsPDQ_________________
Q86UE4	S311	Sugiyama	MTDH AEG1 LYRIC	VKLssQIsAGEEKWNsVsPAsAGKRKtEPSAWsQDtGDANt
Q86V81	S239	Sugiyama	ALYREF ALY BEF THOC4	tRGGARGRGRGAGRNSKQQLsAEELDAQLDAyNARMDts__
Q86V81	T148	Sugiyama	ALYREF ALY BEF THOC4	EFGtLKKAAVHYDRsGRsLGtADVHFERKADALKAMKQYNG
Q8IWX8	S822	Sugiyama	CHERP DAN26 SCAF6	SKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDSRLGEE
Q8IWX8	T819	Sugiyama	CHERP DAN26 SCAF6	RSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDSRL
Q8IYS1	S27	Sugiyama	PM20D2 ACY1L2	RPVEGGACNGRSELELLKLRsAECIDEAAERLGALSRAIWS
Q8N1F7	S112	Sugiyama	NUP93 KIAA0095	PVKDTDIQGFLKNEKDNALLsAIEESRKRtFGMAEEYHRES
Q8NBJ5	S612	Sugiyama	COLGALT1 GLT25D1 PSEC0241	QKMREQQALSREAKNsDVLQsPLDsAARDEL__________
Q8NBJ5	S616	Sugiyama	COLGALT1 GLT25D1 PSEC0241	EQQALSREAKNsDVLQsPLDsAARDEL______________
Q8NBJ7	S264	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	AAEQDMRVLRGAsWIDtADGsANHRARVttRMGNtPDsAsD
Q8NBJ7	S281	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	ADGsANHRARVttRMGNtPDsAsDNLGFRCAADAGRPPGEL
Q8NBJ7	T260	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	SPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMGNtPD
Q8NBS9	S129	Sugiyama	TXNDC5 TLP46 UNQ364/PRO700	MEDAKVYVAKVDCtAHsDVCsAQGVRGYPTLKLFKPGQEAV
Q8NBS9	S255	Sugiyama	TXNDC5 TLP46 UNQ364/PRO700	EHSETVKIGKVDCtQHyELCsGNQVRGyPtLLWFRDGKKVD
Q8NFD5	S1744	Sugiyama	ARID1B BAF250B DAN15 KIAA1235 OSA2	ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q8TB72	S82	Sugiyama	PUM2 KIAA0235 PUMH2	MVQRRsGQGFHGNsEVNAILsPRsEsGGLGVsMVEYVLsss
Q8TD19	S29	Sugiyama	NEK9 KIAA1995 NEK8 NERCC	RHCDsINSDFGSEsGGCGDssPGPSASQGPRAGGGAAEQEE
Q92530	S152	Sugiyama	PSMF1	SRIVSGIITPIHEQWEKANVssPHREFPPAtAREVDPLRIP
Q92530	T162	Sugiyama	PSMF1	IHEQWEKANVssPHREFPPAtAREVDPLRIPPHHPHTSRQP
Q92734	S183	Sugiyama	TFG	AsMsAFDPLKNQDEINKNVMsAFGLtDDQVsGPPsAPAEDR
Q92734	S197	Sugiyama	TFG	INKNVMsAFGLtDDQVsGPPsAPAEDRSGTPDSIASSSSAA
Q92804	S295	Sugiyama	TAF15 RBP56 TAF2N	TDKDTGKPKGEAtVsFDDPPsAKAAIDWFDGKEFHGNIIKV
Q96C19	S74	Sugiyama	EFHD2 SWS1	ELSAKLLRRADLNQGIGEPQsPsRRVFNPytEFKEFSRKQI
Q96F86	S507	Sugiyama	EDC3 LSM16 YJDC YJEFN2 PP844	QEVGINYHSPFGCKFVIPLHsA___________________
Q99460	T830	Sugiyama	PSMD1	TFAYPAPLEVPKEKEKEKVStAVLsItAKAKKKEKEKEKKE
Q99460	T836	Sugiyama	PSMD1	PLEVPKEKEKEKVStAVLsItAKAKKKEKEKEKKEEEKMEV
Q99497	T154	Sugiyama	PARK7	MNGGHytysENRVEKDGLILtSRGPGTSFEFALAIVEALNG
Q99613	S639	Sugiyama	EIF3C EIF3S8	CAFRQGLTKDAHNALLDIQssGRAKELLGQGLLLRSLQERN
Q99733	S53	Sugiyama	NAP1L4 NAP2	QNPRVLAALQERLDNVPHtPssyIEtLPKAVKRRINALKQL
Q99733	T51	Sugiyama	NAP1L4 NAP2	VMQNPRVLAALQERLDNVPHtPssyIEtLPKAVKRRINALK
Q99759	S145	Sugiyama	MAP3K3 MAPKKK3 MEKK3	RNHNsssPHSGVSRQVRIKAsQsAGDINtIyQPPEPRsRHL
Q99759	S147	Sugiyama	MAP3K3 MAPKKK3 MEKK3	HNsssPHSGVSRQVRIKAsQsAGDINtIyQPPEPRsRHLsV
Q99759	S166	Sugiyama	MAP3K3 MAPKKK3 MEKK3	QsAGDINtIyQPPEPRsRHLsVssQNPGRssPPPGYVPERQ
Q99759	S176	Sugiyama	MAP3K3 MAPKKK3 MEKK3	QPPEPRsRHLsVssQNPGRssPPPGYVPERQQHIARQGSYT
Q99759	S250	Sugiyama	MAP3K3 MAPKKK3 MEKK3	SLDRSADSPSFRKSRMSRAQsFPDNRQEysDREtQLYDKGV
Q99759	S337	Sugiyama	MAP3K3 MAPKKK3 MEKK3	tNGENMGLAVQYLDPRGRLRsADsENALsVQERNVPTKsPs
Q99759	S340	Sugiyama	MAP3K3 MAPKKK3 MEKK3	ENMGLAVQYLDPRGRLRsADsENALsVQERNVPTKsPsAPI
Q99759	S345	Sugiyama	MAP3K3 MAPKKK3 MEKK3	AVQYLDPRGRLRsADsENALsVQERNVPTKsPsAPINWRRG
Q99759	T153	Sugiyama	MAP3K3 MAPKKK3 MEKK3	HSGVSRQVRIKAsQsAGDINtIyQPPEPRsRHLsVssQNPG
Q99759	T307	Sugiyama	MAP3K3 MAPKKK3 MEKK3	DYSDGRRtFPRIRRHQGNLFtLVPssRsLstNGENMGLAVQ
Q99759	Y258	Sugiyama	MAP3K3 MAPKKK3 MEKK3	PSFRKSRMSRAQsFPDNRQEysDREtQLYDKGVKGGTYPRR
Q99816	S232	Sugiyama	TSG101	TVGPSRDGtIsEDTIRAsLIsAVSDKLRWRMKEEMDRAQAE
Q9BQE3	S439	Sugiyama	TUBA1C TUBA6	SEAREDMAALEKDyEEVGADsADGEDEGEEy__________
Q9BQE3	T73	Sugiyama	TUBA1C TUBA6	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3	T80	Sugiyama	TUBA1C TUBA6	KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q9BQE3	Y83	Sugiyama	TUBA1C TUBA6	PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q9BS26	S353	Sugiyama	ERP44 KIAA0573 TXNDC4 UNQ532/PRO1075	GDFKDVLIPGKLKQFVFDLHsGKLHREFHHGPDPTDTAPGE
Q9BUL5	S124	Sugiyama	PHF23	AGPTQPGPPRSTFSRLQAPDsAtLLEKMKLKDSLFDLDGPK
Q9BVA1	S75	Sugiyama	TUBB2B	tGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q9BVP2	S53	Sugiyama	GNL3 E2IG3 NS	RKEAKKRGHKKPRKDPGVPNsAPFKEALLREAELRKQRLEE
Q9BXP5	S493	Sugiyama	SRRT ARS2 ASR2	VNIKEICWNLQNIRLRECELsPGVNRDLTRRVRNINGITQH
Q9BYX7	S365	Sugiyama	POTEKP ACTBL3 FKSG30	ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
Q9C0C2	S1103	Sugiyama	TNKS1BP1 KIAA1741 TAB182	KRGWVGEFSLSVGPQREAAFsPGQQDWsRDFCIEASERsyQ
Q9C0C2	S435	Sugiyama	TNKS1BP1 KIAA1741 TAB182	DAHLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAALPQGQG
Q9C0C2	S437	Sugiyama	TNKS1BP1 KIAA1741 TAB182	HLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAALPQGQGsQ
Q9C0C2	S77	Sugiyama	TNKS1BP1 KIAA1741 TAB182	PSLLVPVGPRPPRGPLAELPsARKMNMLAGPQPYGGSKRPL
Q9H4A4	S19	Sugiyama	RNPEP APB	__MAsGEHsPGsGAARRPLHsAQAVDVAsAsNFRAFELLHL
Q9H4A4	S27	Sugiyama	RNPEP APB	sPGsGAARRPLHsAQAVDVAsAsNFRAFELLHLHLDLRAEF
Q9H6F5	S80	Sugiyama	CCDC86 CYCLON	ERPPKtsPGsPRLQQGAGLEsPQGQPEPGAAsPQRQQDLHL
Q9NQ39	S157	Sugiyama	RPS10P5 RPS10L	TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9P265	T144	Sugiyama	DIP2B KIAA1463	PTKRRSTFVQsPADACtPPDtssAsEDEGsLRRQAALSAAL
Q9UHB6	S490	Sugiyama	LIMA1 EPLIN SREBP3 PP624	ENEEILERPAQLANAREtPHsPGVEDAPIAKVGVLAAsMEA
Q9UJY1	S27	Sugiyama	HSPB8 CRYAC E2IG1 HSP22 PP1629	PFSCHYPsRLRRDPFRDsPLsSRLLDDGFGMDPFPDDLTAS
Q9UNX3	T8	Sugiyama	RPL26L1 RPL26P1	_____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Q9UQ35	S2141	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sMsPtPLDRCRsPGMLEPLGssRtPMsVLQQAGGsMMDGPG
Q9UQ35	S2272	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	tAVNLADsRtPAAAAAMNLAsPRtAVAPsAVNLADPRtPtA
Q9UQ35	S2453	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	QAPsQsLLPPAQDQPRsPVPsAFsDQsRCLIAQTTPVAGSQ
Q9Y266	T303	Sugiyama	NUDC	tRsMVEKMMYDQRQKsMGLPtsDEQKKQEILKKFMDQHPEM
Q9Y2V2	S41	Sugiyama	CARHSP1	LDtPRsRERsPsPLRGNVVPsPLPtRRtRtFsAtVRASQGP
Q9Y2W1	S219	Sugiyama	THRAP3 BCLAF2 TRAP150	DEAKEQtFsGGtsQDTKAsEssKPWPDAtyGtGsAsRAsAV
Q9Y2W1	S243	Sugiyama	THRAP3 BCLAF2 TRAP150	WPDAtyGtGsAsRAsAVsELsPRERsPALKsPLQsVVVRRR
Q9Y2W2	S237	Sugiyama	WBP11 NPWBP SIPP1 SNP70	RKVGFALDLPPRRRDEDMLysPELAQRGHDDDVSSTSEDDG
Q9Y3F4	S228	Sugiyama	STRAP MAWD UNRIP	FHSAVSLDPIKsFEAPAtINsAsLHPEKEFLVAGGEDFKLy
Q9Y3P9	T865	Sugiyama	RABGAP1 HSPC094	LQEANMRLEQENDDLAHELVtSKIALRKDLDNAEEKADALN
Q9Y4P8	S413	Sugiyama	WIPI2 CGI-50	CPLVTQTYGAAAGKGTYVPssPtRLAYTDDLGAVGGACLED
Q9Y4P8	T415	Sugiyama	WIPI2 CGI-50	LVTQTYGAAAGKGTYVPssPtRLAYTDDLGAVGGACLEDEA
Q9Y5M8	S257	Sugiyama	SRPRB PSEC0230	LPLKVEFLECSAKGGRGDVGsADIQDLEKWLAKIA______
Q9Y697	S283	Sugiyama	NFS1 NIFS HUSSY-08	KGVGAIYIRRRPRVRVEALQsGGGQERGMRsGTVPTPLVVG
Q9Y6W5	S442	Sugiyama	WASF2 WAVE2	DTTKPKSSLPAVSDARSDLLsAIRQGFQLRRVEEQREQEKR

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p	ref_path	ref_path_lowest
Cell Cycle	R-HSA-1640170	1.296483e-08	7.887	0	0
Cell Cycle, Mitotic	R-HSA-69278	7.247378e-08	7.140	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	5.515085e-06	5.258	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	5.613372e-06	5.251	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	9.791797e-06	5.009	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	1.042093e-05	4.982	0	0
Regulation of TP53 Activity	R-HSA-5633007	1.033074e-05	4.986	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.381777e-05	4.860	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.381777e-05	4.860	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	1.906661e-05	4.720	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	2.653225e-05	4.576	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	2.653225e-05	4.576	0	0
Chromatin organization	R-HSA-4839726	2.752129e-05	4.560	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	3.614720e-05	4.442	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	3.521899e-05	4.453	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	3.614720e-05	4.442	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	4.674318e-05	4.330	0	0
Nuclear import of Rev protein	R-HSA-180746	4.872932e-05	4.312	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	6.149322e-05	4.211	0	0
Chromatin modifying enzymes	R-HSA-3247509	6.266792e-05	4.203	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	6.059354e-05	4.218	1	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	9.245141e-05	4.034	1	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	8.021775e-05	4.096	0	0
M Phase	R-HSA-68886	6.802880e-05	4.167	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	8.021775e-05	4.096	0	0
Signaling by NTRKs	R-HSA-166520	7.487686e-05	4.126	1	0
Heme signaling	R-HSA-9707616	8.949913e-05	4.048	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	8.021775e-05	4.096	0	0
NRAGE signals death through JNK	R-HSA-193648	6.681894e-05	4.175	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	1.211906e-04	3.917	0	0
Signaling by ALK	R-HSA-201556	1.883124e-04	3.725	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	1.883124e-04	3.725	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	2.875413e-04	3.541	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	3.102759e-04	3.508	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	3.050302e-04	3.516	0	0
Mitotic Prophase	R-HSA-68875	3.259719e-04	3.487	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	3.373298e-04	3.472	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	3.409453e-04	3.467	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	4.083891e-04	3.389	0	0
Signal Transduction	R-HSA-162582	4.165247e-04	3.380	1	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	4.185221e-04	3.378	0	0
Cellular Senescence	R-HSA-2559583	4.764991e-04	3.322	1	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	5.488882e-04	3.261	0	0
Mitotic Prometaphase	R-HSA-68877	5.473845e-04	3.262	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	5.686355e-04	3.245	1	0
tRNA processing in the nucleus	R-HSA-6784531	5.692313e-04	3.245	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	6.141568e-04	3.212	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	6.721476e-04	3.173	1	0
G alpha (12/13) signalling events	R-HSA-416482	6.570411e-04	3.182	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	6.698392e-04	3.174	0	0
G0 and Early G1	R-HSA-1538133	6.861550e-04	3.164	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	7.700144e-04	3.114	0	0
ERK/MAPK targets	R-HSA-198753	8.410828e-04	3.075	1	1
Metabolism of non-coding RNA	R-HSA-194441	8.054220e-04	3.094	0	0
snRNP Assembly	R-HSA-191859	8.054220e-04	3.094	0	0
G1/S-Specific Transcription	R-HSA-69205	7.778807e-04	3.109	0	0
ISG15 antiviral mechanism	R-HSA-1169408	9.200015e-04	3.036	0	0
Cell Cycle Checkpoints	R-HSA-69620	9.583015e-04	3.018	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	9.913613e-04	3.004	0	0
Polo-like kinase mediated events	R-HSA-156711	1.164087e-03	2.934	0	0
Interleukin-17 signaling	R-HSA-448424	2.094294e-03	2.679	1	0
RET signaling	R-HSA-8853659	2.139835e-03	2.670	1	1
Regulation of PTEN gene transcription	R-HSA-8943724	2.228048e-03	2.652	0	0
MAP kinase activation	R-HSA-450294	2.606983e-03	2.584	1	0
Cellular response to heat stress	R-HSA-3371556	2.649106e-03	2.577	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	3.959490e-03	2.402	0	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	4.222489e-03	2.374	0	0
Cell-extracellular matrix interactions	R-HSA-446353	4.222489e-03	2.374	0	0
Amplification of signal from the kinetochores	R-HSA-141424	4.234811e-03	2.373	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	4.234811e-03	2.373	0	0
Regulation of beta-cell development	R-HSA-186712	4.258213e-03	2.371	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	4.785998e-03	2.320	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	5.403945e-03	2.267	0	0
PKMTs methylate histone lysines	R-HSA-3214841	5.531567e-03	2.257	0	0
Repression of WNT target genes	R-HSA-4641265	5.913476e-03	2.228	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	5.692653e-03	2.245	0	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	5.916767e-03	2.228	0	0
CREB phosphorylation	R-HSA-199920	7.325273e-03	2.135	0	0
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	R-HSA-210746	7.325273e-03	2.135	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	6.680686e-03	2.175	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	6.621915e-03	2.179	0	0
Mitotic Anaphase	R-HSA-68882	6.751731e-03	2.171	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	7.247071e-03	2.140	0	0
Oncogenic MAPK signaling	R-HSA-6802957	7.338123e-03	2.134	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	7.498906e-03	2.125	0	0
Signaling by PTK6	R-HSA-8848021	7.498906e-03	2.125	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	7.498906e-03	2.125	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	7.774055e-03	2.109	0	0
Estrogen-dependent gene expression	R-HSA-9018519	8.539281e-03	2.069	0	0
Adipogenesis	R-HSA-9843745	8.544628e-03	2.068	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	8.091609e-03	2.092	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	8.054122e-03	2.094	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	8.379295e-03	2.077	0	0
Gene expression (Transcription)	R-HSA-74160	8.641476e-03	2.063	0	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	8.669290e-03	2.062	0	0
HDMs demethylate histones	R-HSA-3214842	9.165606e-03	2.038	0	0
Circadian clock	R-HSA-9909396	9.331540e-03	2.030	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	9.443132e-03	2.025	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	9.443132e-03	2.025	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	9.705625e-03	2.013	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	9.741978e-03	2.011	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.001251e-02	1.999	0	0
Signaling by ALK in cancer	R-HSA-9700206	1.001251e-02	1.999	0	0
AURKA Activation by TPX2	R-HSA-8854518	1.104884e-02	1.957	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.013794e-02	1.994	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	1.115947e-02	1.952	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	1.115947e-02	1.952	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	1.123028e-02	1.950	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	1.160030e-02	1.936	0	0
HATs acetylate histones	R-HSA-3214847	1.312290e-02	1.882	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	1.342360e-02	1.872	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	1.348285e-02	1.870	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.517718e-02	1.819	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.517718e-02	1.819	0	0
G2/M DNA damage checkpoint	R-HSA-69473	1.461187e-02	1.835	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	1.520825e-02	1.818	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.452261e-02	1.838	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	1.561425e-02	1.806	0	0
Death Receptor Signaling	R-HSA-73887	1.478400e-02	1.830	0	0
Inositol phosphate metabolism	R-HSA-1483249	1.594217e-02	1.797	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	1.612996e-02	1.792	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	1.612996e-02	1.792	0	0
Type I hemidesmosome assembly	R-HSA-446107	1.617414e-02	1.791	0	0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	1.617414e-02	1.791	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	1.628439e-02	1.788	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	1.673047e-02	1.776	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	1.744126e-02	1.758	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	1.813549e-02	1.741	0	0
Signaling by NOTCH1	R-HSA-1980143	1.820569e-02	1.740	0	0
HIV Life Cycle	R-HSA-162587	1.845303e-02	1.734	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	2.061653e-02	1.686	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	1.974059e-02	1.705	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	1.954960e-02	1.709	0	0
Interleukin-15 signaling	R-HSA-8983432	2.061653e-02	1.686	0	0
Homology Directed Repair	R-HSA-5693538	1.885083e-02	1.725	0	0
Signaling by LTK	R-HSA-9842663	2.061653e-02	1.686	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	2.171936e-02	1.663	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	2.223499e-02	1.653	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	2.223499e-02	1.653	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	2.223499e-02	1.653	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	2.249904e-02	1.648	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	2.271166e-02	1.644	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	2.286958e-02	1.641	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	2.286958e-02	1.641	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	2.288777e-02	1.640	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	2.313052e-02	1.636	0	0
TGFBR3 expression	R-HSA-9839394	2.369768e-02	1.625	0	0
Signaling by EGFR	R-HSA-177929	2.534380e-02	1.596	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	2.534380e-02	1.596	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	2.585399e-02	1.587	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	2.585399e-02	1.587	0	0
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	2.910628e-02	1.536	0	0
Myogenesis	R-HSA-525793	2.818944e-02	1.550	0	0
RNA Polymerase II Transcription	R-HSA-73857	2.651681e-02	1.576	0	0
MET interacts with TNS proteins	R-HSA-8875513	2.920313e-02	1.535	0	0
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	2.920313e-02	1.535	0	0
RUNX2 regulates bone development	R-HSA-8941326	2.988097e-02	1.525	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	3.018260e-02	1.520	0	0
Signal attenuation	R-HSA-74749	3.023876e-02	1.519	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	3.023876e-02	1.519	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	3.023876e-02	1.519	0	0
Host Interactions of HIV factors	R-HSA-162909	3.034926e-02	1.518	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	3.088569e-02	1.510	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	3.138958e-02	1.503	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	3.183944e-02	1.497	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	3.214569e-02	1.493	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	3.261781e-02	1.487	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	3.261781e-02	1.487	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	3.288685e-02	1.483	0	0
PIP3 activates AKT signaling	R-HSA-1257604	3.334250e-02	1.477	0	0
Notch-HLH transcription pathway	R-HSA-350054	3.439289e-02	1.464	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	3.448793e-02	1.462	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	3.475629e-02	1.459	0	0
ESR-mediated signaling	R-HSA-8939211	3.647160e-02	1.438	0	0
Cardiogenesis	R-HSA-9733709	3.668439e-02	1.436	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	3.924225e-02	1.406	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	3.889917e-02	1.410	0	0
G2/M Transition	R-HSA-69275	3.741629e-02	1.427	0	0
Generic Transcription Pathway	R-HSA-212436	3.812557e-02	1.419	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	3.668439e-02	1.436	0	0
ChREBP activates metabolic gene expression	R-HSA-163765	3.947032e-02	1.404	0	0
G2/M Checkpoints	R-HSA-69481	4.057305e-02	1.392	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	4.099558e-02	1.387	1	0
MAPK family signaling cascades	R-HSA-5683057	4.156502e-02	1.381	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	4.193698e-02	1.377	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	4.199855e-02	1.377	0	0
Mitotic G2-G2/M phases	R-HSA-453274	4.200877e-02	1.377	0	0
Signaling by NOTCH3	R-HSA-9012852	4.325183e-02	1.364	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	4.394213e-02	1.357	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	4.464575e-02	1.350	0	0
PTK6 Expression	R-HSA-8849473	4.464575e-02	1.350	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	4.464575e-02	1.350	0	0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	4.464575e-02	1.350	0	0
Intracellular signaling by second messengers	R-HSA-9006925	4.484179e-02	1.348	0	0
Regulation of gene expression in beta cells	R-HSA-210745	4.517037e-02	1.345	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	4.589883e-02	1.338	0	0
Gene Silencing by RNA	R-HSA-211000	4.770908e-02	1.321	0	0
Signaling by MET	R-HSA-6806834	4.777603e-02	1.321	0	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	5.024208e-02	1.299	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	5.015291e-02	1.300	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	5.015291e-02	1.300	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	5.015291e-02	1.300	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	5.015291e-02	1.300	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	5.046929e-02	1.297	0	0
Centrosome maturation	R-HSA-380287	5.265022e-02	1.279	0	0
Oncogene Induced Senescence	R-HSA-2559585	5.494000e-02	1.260	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	5.046929e-02	1.297	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	5.046929e-02	1.297	0	0
Activation of RAC1	R-HSA-428540	5.024208e-02	1.299	0	0
Interleukin-2 family signaling	R-HSA-451927	5.046929e-02	1.297	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	5.580853e-02	1.253	0	0
Signaling by TGFB family members	R-HSA-9006936	5.190823e-02	1.285	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	5.129926e-02	1.290	0	0
Signalling to ERKs	R-HSA-187687	5.494000e-02	1.260	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	5.678987e-02	1.246	0	0
FLT3 Signaling	R-HSA-9607240	5.682121e-02	1.245	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	5.796467e-02	1.237	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	5.796467e-02	1.237	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	5.796467e-02	1.237	0	0
Signaling by RAS mutants	R-HSA-6802949	5.796467e-02	1.237	0	0
Signaling by TGFBR3	R-HSA-9839373	5.796467e-02	1.237	0	0
Diseases of DNA repair	R-HSA-9675135	5.796467e-02	1.237	0	0
RSK activation	R-HSA-444257	5.916333e-02	1.228	0	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	5.921844e-02	1.228	1	0
MyD88-independent TLR4 cascade	R-HSA-166166	5.921844e-02	1.228	1	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	5.924286e-02	1.227	0	0
HIV Infection	R-HSA-162906	6.023079e-02	1.220	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	6.184043e-02	1.209	0	0
MET activates RAS signaling	R-HSA-8851805	6.257397e-02	1.204	0	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	6.257397e-02	1.204	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	6.257397e-02	1.204	0	0
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	6.634173e-02	1.178	0	0
IRS activation	R-HSA-74713	6.634173e-02	1.178	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	6.634173e-02	1.178	0	0
Activation of the AP-1 family of transcription factors	R-HSA-450341	7.588556e-02	1.120	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	6.789068e-02	1.168	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	7.146476e-02	1.146	0	0
Separation of Sister Chromatids	R-HSA-2467813	6.524913e-02	1.185	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	7.356848e-02	1.133	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	7.356848e-02	1.133	0	0
Signaling by RAF1 mutants	R-HSA-9656223	6.368171e-02	1.196	0	0
Signaling by ERBB2	R-HSA-1227986	7.084690e-02	1.150	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	7.195912e-02	1.143	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	6.995394e-02	1.155	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	7.084690e-02	1.150	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	7.084690e-02	1.150	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	7.084690e-02	1.150	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	7.084690e-02	1.150	0	0
NGF-stimulated transcription	R-HSA-9031628	7.146476e-02	1.146	0	0
Cellular responses to stress	R-HSA-2262752	7.088825e-02	1.149	1	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	7.084690e-02	1.150	0	0
Glycolysis	R-HSA-70171	6.690925e-02	1.175	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	6.634173e-02	1.178	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	7.645865e-02	1.117	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	7.645865e-02	1.117	0	0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	7.645865e-02	1.117	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	7.645865e-02	1.117	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	7.645865e-02	1.117	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	7.645865e-02	1.117	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	7.680912e-02	1.115	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	7.951238e-02	1.100	0	0
mTORC1-mediated signalling	R-HSA-166208	8.027706e-02	1.095	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	8.301110e-02	1.081	0	0
Nervous system development	R-HSA-9675108	8.448913e-02	1.073	1	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	8.647657e-02	1.063	0	0
MITF-M-dependent gene expression	R-HSA-9856651	8.981200e-02	1.047	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	9.020485e-02	1.045	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	9.020485e-02	1.045	0	0
Noncanonical activation of NOTCH3	R-HSA-9017802	9.020485e-02	1.045	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	9.067306e-02	1.043	1	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	9.067306e-02	1.043	1	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	9.067306e-02	1.043	1	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	9.186342e-02	1.037	0	0
Regulation of KIT signaling	R-HSA-1433559	9.186342e-02	1.037	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	9.333389e-02	1.030	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	9.471425e-02	1.024	0	0
Signaling by Leptin	R-HSA-2586552	9.471425e-02	1.024	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	9.828288e-02	1.008	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	9.828288e-02	1.008	0	0
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	9.828288e-02	1.008	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	9.828288e-02	1.008	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	9.828288e-02	1.008	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	9.828288e-02	1.008	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	9.828288e-02	1.008	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	9.828288e-02	1.008	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	9.828288e-02	1.008	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	9.828288e-02	1.008	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	9.828288e-02	1.008	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	9.828288e-02	1.008	0	0
G2/M DNA replication checkpoint	R-HSA-69478	1.170801e-01	0.932	0	0
Formation of the posterior neural plate	R-HSA-9832991	1.155107e-01	0.937	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	1.087327e-01	0.964	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	1.157356e-01	0.937	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.071700e-01	0.970	0	0
MAP2K and MAPK activation	R-HSA-5674135	1.178654e-01	0.929	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	9.639444e-02	1.016	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	1.108356e-01	0.955	0	0
Formation of definitive endoderm	R-HSA-9823730	1.157356e-01	0.937	0	0
Regulation of TP53 Expression	R-HSA-6804754	9.828288e-02	1.008	0	0
Interleukin-2 signaling	R-HSA-9020558	1.155107e-01	0.937	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	1.168619e-01	0.932	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	1.178654e-01	0.929	0	0
Mitochondrial biogenesis	R-HSA-1592230	1.050449e-01	0.979	0	0
Nef and signal transduction	R-HSA-164944	1.170801e-01	0.932	0	0
Formation of the anterior neural plate	R-HSA-9823739	1.087327e-01	0.964	0	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	1.170801e-01	0.932	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	1.005437e-01	0.998	1	1
Axon guidance	R-HSA-422475	9.875459e-02	1.005	1	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	9.828288e-02	1.008	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.051031e-01	0.978	0	0
Neurodegenerative Diseases	R-HSA-8863678	1.051031e-01	0.978	0	0
Apoptotic execution phase	R-HSA-75153	1.058460e-01	0.975	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	1.187718e-01	0.925	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	1.091751e-01	0.962	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.102831e-01	0.957	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	1.188991e-01	0.925	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	1.188991e-01	0.925	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	1.188991e-01	0.925	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	1.192814e-01	0.923	0	0
RNA Polymerase III Transcription	R-HSA-74158	1.192814e-01	0.923	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.200242e-01	0.921	0	0
Defective Base Excision Repair Associated with NEIL1	R-HSA-9616334	1.233036e-01	0.909	0	0
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.233036e-01	0.909	0	0
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	1.233036e-01	0.909	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	1.256809e-01	0.901	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	1.263947e-01	0.898	0	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	1.269908e-01	0.896	0	0
Differentiation of T cells	R-HSA-9945266	1.269908e-01	0.896	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	1.292105e-01	0.889	0	0
MTOR signalling	R-HSA-165159	1.292105e-01	0.889	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.320061e-01	0.879	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.320061e-01	0.879	0	0
Signalling to RAS	R-HSA-167044	1.320061e-01	0.879	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	1.331702e-01	0.876	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	1.335797e-01	0.874	0	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	1.335797e-01	0.874	0	0
PTEN Regulation	R-HSA-6807070	1.361837e-01	0.866	0	0
Cellular responses to stimuli	R-HSA-8953897	1.371701e-01	0.863	1	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	1.381048e-01	0.860	0	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	1.381048e-01	0.860	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.381048e-01	0.860	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	1.396143e-01	0.855	0	0
TBC/RABGAPs	R-HSA-8854214	1.411208e-01	0.850	0	0
Signaling by SCF-KIT	R-HSA-1433557	1.411208e-01	0.850	0	0
MET activates STAT3	R-HSA-8875791	1.413104e-01	0.850	0	0
Activation of BIM and translocation to mitochondria	R-HSA-111446	1.413104e-01	0.850	0	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	1.413104e-01	0.850	0	0
MET activates PTPN11	R-HSA-8865999	1.413104e-01	0.850	0	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	1.413104e-01	0.850	0	0
Inhibition of nitric oxide production	R-HSA-9636249	1.413104e-01	0.850	0	0
Influenza Infection	R-HSA-168255	1.422085e-01	0.847	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	1.443153e-01	0.841	0	0
MET promotes cell motility	R-HSA-8875878	1.444780e-01	0.840	0	0
Regulation of HMOX1 expression and activity	R-HSA-9707587	1.874397e-01	0.727	0	0
Regulation of gap junction activity	R-HSA-191650	1.874397e-01	0.727	0	0
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	1.874397e-01	0.727	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	1.874397e-01	0.727	0	0
Signaling by MAP2K mutants	R-HSA-9652169	1.874397e-01	0.727	0	0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	1.874397e-01	0.727	0	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	1.874397e-01	0.727	0	0
Regulation of PTEN localization	R-HSA-8948747	1.465162e-01	0.834	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	1.465162e-01	0.834	0	0
SOS-mediated signalling	R-HSA-112412	1.465162e-01	0.834	0	0
Downregulation of ERBB4 signaling	R-HSA-1253288	1.780467e-01	0.749	0	0
MET receptor recycling	R-HSA-8875656	1.780467e-01	0.749	0	0
SHC-related events triggered by IGF1R	R-HSA-2428933	1.623035e-01	0.790	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	1.465450e-01	0.834	0	0
SHC1 events in ERBB4 signaling	R-HSA-1250347	1.465450e-01	0.834	0	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	1.878983e-01	0.726	0	0
Formation of axial mesoderm	R-HSA-9796292	1.878983e-01	0.726	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	1.672888e-01	0.777	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	1.492980e-01	0.826	0	0
Ephrin signaling	R-HSA-3928664	1.891045e-01	0.723	0	0
Interleukin receptor SHC signaling	R-HSA-912526	1.866726e-01	0.729	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	1.620667e-01	0.790	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.825196e-01	0.739	0	0
RAF activation	R-HSA-5673000	1.775212e-01	0.751	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	1.800687e-01	0.745	0	0
mRNA 3'-end processing	R-HSA-72187	1.734913e-01	0.761	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	1.591960e-01	0.798	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	1.518943e-01	0.818	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	1.492980e-01	0.826	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	1.891045e-01	0.723	0	0
Recycling pathway of L1	R-HSA-437239	1.940517e-01	0.712	0	0
Resolution of D-Loop Structures	R-HSA-5693537	1.620667e-01	0.790	0	0
Adrenoceptors	R-HSA-390696	1.780467e-01	0.749	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	1.465450e-01	0.834	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	1.472712e-01	0.832	0	0
S Phase	R-HSA-69242	1.579143e-01	0.802	0	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	1.623035e-01	0.790	0	0
Frs2-mediated activation	R-HSA-170968	1.878983e-01	0.726	0	0
G1/S Transition	R-HSA-69206	1.687045e-01	0.773	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	1.867985e-01	0.729	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	1.866726e-01	0.729	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	1.675449e-01	0.776	0	0
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	1.866726e-01	0.729	0	0
Cilium Assembly	R-HSA-5617833	1.678012e-01	0.775	0	0
Signaling by Interleukins	R-HSA-449147	1.729789e-01	0.762	1	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	1.726161e-01	0.763	1	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	1.815690e-01	0.741	1	0
Activation of ATR in response to replication stress	R-HSA-176187	1.472712e-01	0.832	0	0
Signaling by VEGF	R-HSA-194138	1.687045e-01	0.773	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	1.472712e-01	0.832	0	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	1.874397e-01	0.727	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	1.891045e-01	0.723	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	1.867985e-01	0.729	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.491071e-01	0.827	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	1.491071e-01	0.827	0	0
Signaling by Hippo	R-HSA-2028269	1.672888e-01	0.777	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	1.492980e-01	0.826	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	1.891045e-01	0.723	0	0
Cell junction organization	R-HSA-446728	1.949971e-01	0.710	0	0
DNA Double Strand Break Response	R-HSA-5693606	1.957592e-01	0.708	0	0
Signaling by ERBB4	R-HSA-1236394	1.991800e-01	0.701	0	0
DAP12 signaling	R-HSA-2424491	2.002990e-01	0.698	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	2.002990e-01	0.698	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	2.002990e-01	0.698	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	2.002990e-01	0.698	0	0
Activation of BH3-only proteins	R-HSA-114452	2.002990e-01	0.698	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	2.019998e-01	0.695	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	2.043880e-01	0.690	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	2.066002e-01	0.685	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	2.314096e-01	0.636	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.314096e-01	0.636	0	0
Drug-mediated inhibition of MET activation	R-HSA-9734091	2.314096e-01	0.636	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.314096e-01	0.636	0	0
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	2.314096e-01	0.636	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.314096e-01	0.636	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.314096e-01	0.636	0	0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4	R-HSA-9630791	2.314096e-01	0.636	0	0
Impaired BRCA2 binding to SEM1 (DSS1)	R-HSA-9763198	2.314096e-01	0.636	0	0
Impaired BRCA2 translocation to the nucleus	R-HSA-9709275	2.314096e-01	0.636	0	0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4	R-HSA-9632697	2.314096e-01	0.636	0	0
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	2.314096e-01	0.636	0	0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects	R-HSA-9632693	3.261906e-01	0.487	0	0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects	R-HSA-9630750	3.261906e-01	0.487	0	0
Signaling by TCF7L2 mutants	R-HSA-5339700	3.261906e-01	0.487	0	0
Defective MMADHC causes MMAHCD	R-HSA-3359473	3.261906e-01	0.487	0	0
PTEN Loss of Function in Cancer	R-HSA-5674404	3.261906e-01	0.487	0	0
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	3.261906e-01	0.487	0	0
Defective VWF binding to collagen type I	R-HSA-9845622	3.261906e-01	0.487	0	0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9632700	3.261906e-01	0.487	0	0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5660686	3.261906e-01	0.487	0	0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5619101	3.261906e-01	0.487	0	0
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	3.261906e-01	0.487	0	0
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	3.261906e-01	0.487	0	0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9630794	3.261906e-01	0.487	0	0
Intestinal infectious diseases	R-HSA-8942233	3.261906e-01	0.487	0	0
SMAC (DIABLO) binds to IAPs	R-HSA-111463	2.352525e-01	0.628	0	0
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	2.352525e-01	0.628	0	0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	2.352525e-01	0.628	0	0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	2.112105e-01	0.675	0	0
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	2.836329e-01	0.547	0	0
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	2.836329e-01	0.547	0	0
Cam-PDE 1 activation	R-HSA-111957	2.836329e-01	0.547	0	0
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	2.836329e-01	0.547	0	0
CDC6 association with the ORC:origin complex	R-HSA-68689	2.836329e-01	0.547	0	0
PTK6 Regulates Cell Cycle	R-HSA-8849470	2.836329e-01	0.547	0	0
Signaling by MAPK mutants	R-HSA-9652817	2.836329e-01	0.547	0	0
Signaling by RNF43 mutants	R-HSA-5340588	2.836329e-01	0.547	0	0
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	4.092881e-01	0.388	0	0
Signalling to ERK5	R-HSA-198765	4.092881e-01	0.388	1	1
Defective DHDDS causes RP59	R-HSA-4755609	4.092881e-01	0.388	0	0
Defective VWF cleavage by ADAMTS13 variant	R-HSA-9845621	4.092881e-01	0.388	0	0
Enhanced cleavage of VWF variant by ADAMTS13	R-HSA-9845619	4.092881e-01	0.388	0	0
Glycogen storage disease type IV (GBE1)	R-HSA-3878781	4.092881e-01	0.388	0	0
Defective F8 sulfation at Y1699	R-HSA-9674519	4.092881e-01	0.388	0	0
Regulation of the apoptosome activity	R-HSA-9627069	2.455665e-01	0.610	0	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	2.455665e-01	0.610	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	2.146726e-01	0.668	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	2.146726e-01	0.668	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	3.317145e-01	0.479	0	0
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	3.317145e-01	0.479	0	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	3.317145e-01	0.479	0	0
Defective CHST14 causes EDS, musculocontractural type	R-HSA-3595174	3.317145e-01	0.479	0	0
H139Hfs13* PPM1K causes a mild variant of MSUD	R-HSA-9912529	3.317145e-01	0.479	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	2.807030e-01	0.552	0	0
Activated NTRK3 signals through RAS	R-HSA-9034864	2.807030e-01	0.552	0	0
Erythropoietin activates RAS	R-HSA-9027284	2.424072e-01	0.615	0	0
Processive synthesis on the lagging strand	R-HSA-69183	2.424072e-01	0.615	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	2.424072e-01	0.615	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	2.708852e-01	0.567	0	0
Activated NTRK2 signals through RAS	R-HSA-9026519	3.162442e-01	0.500	0	0
ERKs are inactivated	R-HSA-202670	3.162442e-01	0.500	1	1
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	3.162442e-01	0.500	0	0
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	3.788356e-01	0.422	0	0
MET activates PI3K/AKT signaling	R-HSA-8851907	3.788356e-01	0.422	0	0
Synthesis of PIPs in the nucleus	R-HSA-8847453	3.788356e-01	0.422	0	0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	3.788356e-01	0.422	0	0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	3.788356e-01	0.422	0	0
Disinhibition of SNARE formation	R-HSA-114516	3.788356e-01	0.422	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	3.788356e-01	0.422	0	0
PLC-gamma1 signalling	R-HSA-167021	4.821419e-01	0.317	0	0
Activated NTRK3 signals through PLCG1	R-HSA-9034793	4.821419e-01	0.317	0	0
Defective MMACHC causes MAHCC	R-HSA-3359474	4.821419e-01	0.317	0	0
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	4.821419e-01	0.317	0	0
Signalling to STAT3	R-HSA-198745	4.821419e-01	0.317	0	0
Invadopodia formation	R-HSA-8941237	4.821419e-01	0.317	0	0
Classical Kir channels	R-HSA-1296053	4.821419e-01	0.317	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	2.998963e-01	0.523	0	0
EGFR downregulation	R-HSA-182971	2.187159e-01	0.660	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	3.518531e-01	0.454	0	0
Polymerase switching	R-HSA-69091	3.518531e-01	0.454	0	0
Leading Strand Synthesis	R-HSA-69109	3.518531e-01	0.454	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	3.518531e-01	0.454	0	0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	4.245022e-01	0.372	0	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	4.245022e-01	0.372	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	4.245022e-01	0.372	0	0
Regulation of NPAS4 mRNA translation	R-HSA-9768778	4.245022e-01	0.372	0	0
Formation of annular gap junctions	R-HSA-196025	4.245022e-01	0.372	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	4.245022e-01	0.372	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	3.097430e-01	0.509	0	0
CD28 dependent Vav1 pathway	R-HSA-389359	3.872332e-01	0.412	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	3.872332e-01	0.412	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	3.587269e-01	0.445	0	0
Signaling by Erythropoietin	R-HSA-9006335	3.151437e-01	0.501	0	0
Late endosomal microautophagy	R-HSA-9615710	3.151437e-01	0.501	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	2.816543e-01	0.550	0	0
Activation of the pre-replicative complex	R-HSA-68962	3.379934e-01	0.471	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	4.221276e-01	0.375	0	0
Removal of the Flap Intermediate	R-HSA-69166	4.221276e-01	0.375	0	0
Retrograde neurotrophin signalling	R-HSA-177504	4.221276e-01	0.375	0	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	4.683566e-01	0.329	0	0
Lipophagy	R-HSA-9613354	4.683566e-01	0.329	0	0
Gap junction degradation	R-HSA-190873	4.683566e-01	0.329	0	0
5-Phosphoribose 1-diphosphate biosynthesis	R-HSA-73843	4.683566e-01	0.329	0	0
Activated NTRK2 signals through PLCG1	R-HSA-9026527	5.460142e-01	0.263	0	0
HCN channels	R-HSA-1296061	5.460142e-01	0.263	0	0
AKT-mediated inactivation of FOXO1A	R-HSA-211163	5.460142e-01	0.263	0	0
Signaling by LRP5 mutants	R-HSA-5339717	5.460142e-01	0.263	0	0
Defective LFNG causes SCDO3	R-HSA-5083630	5.460142e-01	0.263	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	3.195207e-01	0.496	0	0
HIV Transcription Initiation	R-HSA-167161	3.195207e-01	0.496	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	3.195207e-01	0.496	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	3.388079e-01	0.470	0	0
Negative regulation of MET activity	R-HSA-6807004	4.174483e-01	0.379	0	0
Spry regulation of FGF signaling	R-HSA-1295596	4.563184e-01	0.341	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	4.563184e-01	0.341	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	4.563184e-01	0.341	0	0
SHC1 events in EGFR signaling	R-HSA-180336	4.563184e-01	0.341	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	3.582599e-01	0.446	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	4.123309e-01	0.385	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	3.181448e-01	0.497	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	3.016798e-01	0.520	1	1
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	4.072201e-01	0.390	0	0
Lagging Strand Synthesis	R-HSA-69186	4.463787e-01	0.350	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	5.101512e-01	0.292	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	3.710767e-01	0.431	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	4.378281e-01	0.359	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	3.974490e-01	0.401	0	0
Cellular response to hypoxia	R-HSA-1234174	3.676975e-01	0.435	0	0
PPARA activates gene expression	R-HSA-1989781	2.744956e-01	0.561	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	3.643502e-01	0.438	0	0
Striated Muscle Contraction	R-HSA-390522	4.302481e-01	0.366	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	4.748461e-01	0.323	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	4.748461e-01	0.323	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	3.721217e-01	0.429	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	4.366836e-01	0.360	0	0
Translation initiation complex formation	R-HSA-72649	4.296227e-01	0.367	0	0
mRNA Splicing	R-HSA-72172	3.441815e-01	0.463	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	5.027380e-01	0.299	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	5.027380e-01	0.299	0	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	5.218960e-01	0.282	0	0
G beta:gamma signalling through CDC42	R-HSA-8964616	5.218960e-01	0.282	0	0
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	5.497271e-01	0.260	0	0
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	6.020118e-01	0.220	0	0
Interleukin-36 pathway	R-HSA-9014826	6.020118e-01	0.220	0	0
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	6.020118e-01	0.220	0	0
FLT3 signaling by CBL mutants	R-HSA-9706377	6.020118e-01	0.220	0	0
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	6.020118e-01	0.220	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	3.790051e-01	0.421	0	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	5.530182e-01	0.257	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	5.530182e-01	0.257	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	5.138177e-01	0.289	0	0
Deadenylation of mRNA	R-HSA-429947	5.564232e-01	0.255	0	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	5.869959e-01	0.231	0	0
DS-GAG biosynthesis	R-HSA-2022923	5.869959e-01	0.231	0	0
Synthesis of diphthamide-EEF2	R-HSA-5358493	5.869959e-01	0.231	0	0
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	5.869959e-01	0.231	0	0
PI3K events in ERBB4 signaling	R-HSA-1250342	5.869959e-01	0.231	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	5.597904e-01	0.252	0	0
GAB1 signalosome	R-HSA-180292	5.829012e-01	0.234	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	5.829012e-01	0.234	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	5.829012e-01	0.234	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	5.829012e-01	0.234	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	5.648818e-01	0.248	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	5.648818e-01	0.248	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	5.688969e-01	0.245	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	6.134086e-01	0.212	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	6.045827e-01	0.219	0	0
MET activates PTK2 signaling	R-HSA-8874081	6.068327e-01	0.217	0	0
Regulation of signaling by CBL	R-HSA-912631	6.114808e-01	0.214	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	6.114808e-01	0.214	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	6.114808e-01	0.214	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	6.219245e-01	0.206	0	0
Maple Syrup Urine Disease	R-HSA-9865114	6.219245e-01	0.206	0	0
GRB2 events in EGFR signaling	R-HSA-179812	6.219245e-01	0.206	0	0
Switching of origins to a post-replicative state	R-HSA-69052	6.218281e-01	0.206	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	6.215745e-01	0.207	0	0
Transcription of the HIV genome	R-HSA-167172	4.170690e-01	0.380	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	2.284762e-01	0.641	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	2.485093e-01	0.605	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	3.031759e-01	0.518	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	3.031759e-01	0.518	0	0
FOXO-mediated transcription	R-HSA-9614085	2.076430e-01	0.683	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	3.031759e-01	0.518	0	0
Cyclin D associated events in G1	R-HSA-69231	2.504044e-01	0.601	0	0
G1 Phase	R-HSA-69236	2.504044e-01	0.601	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	4.653680e-01	0.332	0	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	5.218960e-01	0.282	0	0
EPH-Ephrin signaling	R-HSA-2682334	3.683796e-01	0.434	0	0
Cytochrome c-mediated apoptotic response	R-HSA-111461	3.162442e-01	0.500	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	3.151437e-01	0.501	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	3.379934e-01	0.471	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	4.757861e-01	0.323	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	5.750128e-01	0.240	0	0
Formation of apoptosome	R-HSA-111458	2.455665e-01	0.610	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	2.354449e-01	0.628	0	0
p75NTR recruits signalling complexes	R-HSA-209543	3.518531e-01	0.454	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	4.463787e-01	0.350	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	2.450891e-01	0.611	0	0
Insulin receptor signalling cascade	R-HSA-74751	6.054393e-01	0.218	0	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	3.872332e-01	0.412	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	4.757861e-01	0.323	0	0
Aggrephagy	R-HSA-9646399	4.233875e-01	0.373	0	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	5.869959e-01	0.231	0	0
DNA strand elongation	R-HSA-69190	5.597904e-01	0.252	0	0
Rap1 signalling	R-HSA-392517	2.118667e-01	0.674	0	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	3.788356e-01	0.422	0	0
Ovarian tumor domain proteases	R-HSA-5689896	2.274267e-01	0.643	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	2.865029e-01	0.543	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	5.871002e-01	0.231	0	0
Signaling by FGFR4	R-HSA-5654743	2.338408e-01	0.631	0	0
Signaling by FGFR2	R-HSA-5654738	4.898116e-01	0.310	0	0
EPHB-mediated forward signaling	R-HSA-3928662	5.268051e-01	0.278	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	2.836329e-01	0.547	0	0
DCC mediated attractive signaling	R-HSA-418885	2.424072e-01	0.615	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	3.208445e-01	0.494	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	5.023665e-01	0.299	0	0
Cap-dependent Translation Initiation	R-HSA-72737	5.429362e-01	0.265	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	2.744094e-01	0.562	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	2.882704e-01	0.540	0	0
IGF1R signaling cascade	R-HSA-2428924	4.749961e-01	0.323	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	4.302481e-01	0.366	0	0
Signaling by FGFR3	R-HSA-5654741	2.673431e-01	0.573	0	0
Eukaryotic Translation Initiation	R-HSA-72613	5.429362e-01	0.265	0	0
Formation of lateral plate mesoderm	R-HSA-9758920	2.836329e-01	0.547	0	0
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	3.162442e-01	0.500	0	0
Nef Mediated CD4 Down-regulation	R-HSA-167590	3.788356e-01	0.422	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	2.845158e-01	0.546	0	0
PI3K/AKT activation	R-HSA-198203	5.101512e-01	0.292	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	5.027380e-01	0.299	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	4.500375e-01	0.347	0	0
Epigenetic regulation of gene expression	R-HSA-212165	3.532212e-01	0.452	0	0
Sensing of DNA Double Strand Breaks	R-HSA-5693548	5.869959e-01	0.231	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	5.597904e-01	0.252	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	5.721857e-01	0.242	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	4.585230e-01	0.339	0	0
Sema4D in semaphorin signaling	R-HSA-400685	2.272422e-01	0.644	0	0
p75NTR signals via NF-kB	R-HSA-193639	4.563184e-01	0.341	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	3.612202e-01	0.442	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	3.612202e-01	0.442	0	0
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	2.836329e-01	0.547	0	0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	3.518531e-01	0.454	0	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	4.245022e-01	0.372	0	0
RAF-independent MAPK1/3 activation	R-HSA-112409	3.097430e-01	0.509	0	0
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	5.460142e-01	0.263	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	4.455693e-01	0.351	0	0
Apoptotic factor-mediated response	R-HSA-111471	5.829012e-01	0.234	0	0
Meiosis	R-HSA-1500620	5.657257e-01	0.247	0	0
VLDLR internalisation and degradation	R-HSA-8866427	6.219245e-01	0.206	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	4.123309e-01	0.385	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	4.827876e-01	0.316	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.921039e-01	0.308	0	0
Interleukin-20 family signaling	R-HSA-8854691	5.299577e-01	0.276	0	0
Signaling by FGFR1	R-HSA-5654736	4.662321e-01	0.331	0	0
Germ layer formation at gastrulation	R-HSA-9754189	6.114808e-01	0.214	0	0
Long-term potentiation	R-HSA-9620244	2.272422e-01	0.644	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	2.974632e-01	0.527	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	4.378281e-01	0.359	0	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	4.302481e-01	0.366	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	4.664532e-01	0.331	0	0
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	6.219245e-01	0.206	0	0
Signaling by NOTCH	R-HSA-157118	2.261149e-01	0.646	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	2.330337e-01	0.633	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	2.469425e-01	0.607	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	5.546602e-01	0.256	0	0
Post-transcriptional silencing by small RNAs	R-HSA-426496	2.352525e-01	0.628	0	0
Calcineurin activates NFAT	R-HSA-2025928	2.112105e-01	0.675	0	0
Diseases of Cellular Senescence	R-HSA-9630747	4.092881e-01	0.388	0	0
Diseases of cellular response to stress	R-HSA-9675132	4.092881e-01	0.388	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	2.146726e-01	0.668	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	3.292397e-01	0.482	0	0
Nuclear RNA decay	R-HSA-9930044	4.072201e-01	0.390	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	3.105508e-01	0.508	0	0
Molybdenum cofactor biosynthesis	R-HSA-947581	4.748461e-01	0.323	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	5.218960e-01	0.282	0	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	5.497271e-01	0.260	0	0
PTK6 Activates STAT3	R-HSA-8849474	6.020118e-01	0.220	0	0
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	6.020118e-01	0.220	0	0
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	6.020118e-01	0.220	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	5.126732e-01	0.290	0	0
Reduction of cytosolic Ca++ levels	R-HSA-418359	5.869959e-01	0.231	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	5.820664e-01	0.235	0	0
DNA Repair	R-HSA-73894	5.766987e-01	0.239	0	0
Hedgehog 'on' state	R-HSA-5632684	5.909021e-01	0.228	0	0
Protein-protein interactions at synapses	R-HSA-6794362	3.435716e-01	0.464	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	4.168383e-01	0.380	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	3.587269e-01	0.445	0	0
Neurexins and neuroligins	R-HSA-6794361	5.325851e-01	0.274	0	0
Membrane Trafficking	R-HSA-199991	3.882608e-01	0.411	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	3.804693e-01	0.420	0	0
Co-inhibition by PD-1	R-HSA-389948	5.864289e-01	0.232	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	4.123309e-01	0.385	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	6.040028e-01	0.219	0	0
Formation of intermediate mesoderm	R-HSA-9761174	2.455665e-01	0.610	0	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	5.460142e-01	0.263	0	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	5.460142e-01	0.263	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	4.896238e-01	0.310	0	0
Activation of C3 and C5	R-HSA-174577	6.020118e-01	0.220	0	0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	5.869959e-01	0.231	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	3.167912e-01	0.499	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	3.587269e-01	0.445	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	4.185195e-01	0.378	0	0
Gastrulation	R-HSA-9758941	4.415453e-01	0.355	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	2.572074e-01	0.590	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	4.174483e-01	0.379	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	4.444464e-01	0.352	0	0
Signaling by WNT	R-HSA-195721	5.737884e-01	0.241	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	4.072201e-01	0.390	0	0
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	4.896238e-01	0.310	0	0
Killing mechanisms	R-HSA-9664420	4.896238e-01	0.310	0	0
Signaling by FGFR in disease	R-HSA-1226099	5.151118e-01	0.288	0	0
Developmental Biology	R-HSA-1266738	2.620316e-01	0.582	1	0
RAF/MAP kinase cascade	R-HSA-5673001	2.663609e-01	0.575	0	0
Integrin signaling	R-HSA-354192	4.072201e-01	0.390	0	0
Deubiquitination	R-HSA-5688426	4.029510e-01	0.395	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	2.759547e-01	0.559	1	0
Metabolism of RNA	R-HSA-8953854	4.997007e-01	0.301	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	6.068327e-01	0.217	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	5.466914e-01	0.262	0	0
DAP12 interactions	R-HSA-2172127	5.268051e-01	0.278	0	0
Rab regulation of trafficking	R-HSA-9007101	5.555181e-01	0.255	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	3.050625e-01	0.516	1	0
Post NMDA receptor activation events	R-HSA-438064	2.875594e-01	0.541	0	0
Semaphorin interactions	R-HSA-373755	4.577758e-01	0.339	0	0
ARL13B-mediated ciliary trafficking of INPP5E	R-HSA-5624958	3.261906e-01	0.487	0	0
Transport of connexins along the secretory pathway	R-HSA-190827	3.261906e-01	0.487	0	0
TGFBR3 regulates activin signaling	R-HSA-9839406	4.092881e-01	0.388	0	0
Negative regulation of FLT3	R-HSA-9706369	2.708852e-01	0.567	0	0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	4.821419e-01	0.317	0	0
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	4.821419e-01	0.317	0	0
Disorders of Developmental Biology	R-HSA-9675151	2.998963e-01	0.523	0	0
Interleukin-23 signaling	R-HSA-9020933	4.245022e-01	0.372	0	0
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	4.683566e-01	0.329	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	4.683566e-01	0.329	0	0
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	5.460142e-01	0.263	0	0
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	5.460142e-01	0.263	0	0
Downstream signal transduction	R-HSA-186763	3.610126e-01	0.442	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	5.101512e-01	0.292	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	4.022470e-01	0.396	0	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	3.050625e-01	0.516	1	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	3.395015e-01	0.469	1	0
Signaling by NOTCH2	R-HSA-1980145	4.531263e-01	0.344	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	3.961506e-01	0.402	0	0
Reelin signalling pathway	R-HSA-8866376	6.020118e-01	0.220	0	0
NTRK2 activates RAC1	R-HSA-9032759	6.020118e-01	0.220	0	0
Suppression of autophagy	R-HSA-9636569	6.020118e-01	0.220	0	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	5.869959e-01	0.231	0	0
Smooth Muscle Contraction	R-HSA-445355	5.510747e-01	0.259	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	5.382886e-01	0.269	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	2.196463e-01	0.658	1	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	2.503820e-01	0.601	1	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	3.395015e-01	0.469	1	0
Cell-Cell communication	R-HSA-1500931	2.083237e-01	0.681	0	0
Prolonged ERK activation events	R-HSA-169893	2.708852e-01	0.567	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	2.845158e-01	0.546	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	3.643502e-01	0.438	0	0
Collagen degradation	R-HSA-1442490	5.551084e-01	0.256	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	5.838568e-01	0.234	1	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	3.866669e-01	0.413	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	4.827876e-01	0.316	0	0
Interleukin-35 Signalling	R-HSA-8984722	6.219245e-01	0.206	0	0
Apoptosis	R-HSA-109581	2.730164e-01	0.564	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	3.609392e-01	0.443	0	0
Signal transduction by L1	R-HSA-445144	4.174483e-01	0.379	0	0
Protein methylation	R-HSA-8876725	2.424072e-01	0.615	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	3.292397e-01	0.482	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	2.299018e-01	0.638	0	0
Ca2+ pathway	R-HSA-4086398	6.218281e-01	0.206	0	0
FLT3 signaling in disease	R-HSA-9682385	4.981645e-01	0.303	0	0
Netrin-1 signaling	R-HSA-373752	5.268051e-01	0.278	0	0
PECAM1 interactions	R-HSA-210990	2.807030e-01	0.552	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	3.151437e-01	0.501	0	0
MDK and PTN in ALK signaling	R-HSA-9851151	5.460142e-01	0.263	0	0
L1CAM interactions	R-HSA-373760	2.717840e-01	0.566	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	2.631824e-01	0.580	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	2.108514e-01	0.676	0	0
p38MAPK events	R-HSA-171007	2.424072e-01	0.615	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	3.292397e-01	0.482	0	0
Interleukin-21 signaling	R-HSA-9020958	4.683566e-01	0.329	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	4.683566e-01	0.329	0	0
Disorders of Nervous System Development	R-HSA-9697154	6.219245e-01	0.206	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	6.219245e-01	0.206	0	0
Pervasive developmental disorders	R-HSA-9005895	6.219245e-01	0.206	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	2.176930e-01	0.662	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	3.191358e-01	0.496	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	3.974490e-01	0.401	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	4.531263e-01	0.344	0	0
Programmed Cell Death	R-HSA-5357801	4.959492e-01	0.305	0	0
Cytoprotection by HMOX1	R-HSA-9707564	4.211356e-01	0.376	0	0
Regulation of NPAS4 gene expression	R-HSA-9768759	5.530182e-01	0.257	0	0
Tie2 Signaling	R-HSA-210993	3.587269e-01	0.445	0	0
Mismatch Repair	R-HSA-5358508	3.587269e-01	0.445	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	5.777449e-01	0.238	0	0
PI Metabolism	R-HSA-1483255	5.212609e-01	0.283	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	3.615121e-01	0.442	0	0
Breakdown of the nuclear lamina	R-HSA-352238	3.261906e-01	0.487	0	0
Oligomerization of connexins into connexons	R-HSA-190704	3.261906e-01	0.487	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	2.836329e-01	0.547	0	0
Activation of SMO	R-HSA-5635838	2.708852e-01	0.567	0	0
Intracellular oxygen transport	R-HSA-8981607	4.821419e-01	0.317	0	0
Signaling by PDGFR in disease	R-HSA-9671555	2.845158e-01	0.546	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	2.572074e-01	0.590	0	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	4.221276e-01	0.375	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	4.683566e-01	0.329	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	4.563184e-01	0.341	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	4.463787e-01	0.350	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	4.444464e-01	0.352	0	0
RHOBTB3 ATPase cycle	R-HSA-9706019	5.497271e-01	0.260	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	5.564232e-01	0.255	0	0
Signaling by PDGF	R-HSA-186797	5.721857e-01	0.242	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	3.097430e-01	0.509	0	0
Signaling by ROBO receptors	R-HSA-376176	5.409935e-01	0.267	0	0
STING mediated induction of host immune responses	R-HSA-1834941	6.114808e-01	0.214	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	2.422311e-01	0.616	0	0
Interleukin-7 signaling	R-HSA-1266695	3.866669e-01	0.413	0	0
Pexophagy	R-HSA-9664873	5.101512e-01	0.292	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	2.112105e-01	0.675	0	0
Other interleukin signaling	R-HSA-449836	2.118667e-01	0.674	0	0
Regulation of CDH11 gene transcription	R-HSA-9762293	2.112105e-01	0.675	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	3.317145e-01	0.479	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	4.170690e-01	0.380	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	5.027380e-01	0.299	0	0
Suppression of apoptosis	R-HSA-9635465	5.497271e-01	0.260	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	5.065942e-01	0.295	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	2.631824e-01	0.580	0	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	2.112105e-01	0.675	0	0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis	R-HSA-9708296	4.092881e-01	0.388	0	0
MECP2 regulates transcription factors	R-HSA-9022707	3.788356e-01	0.422	0	0
The NLRP1 inflammasome	R-HSA-844455	4.821419e-01	0.317	0	0
Dopamine receptors	R-HSA-390651	5.460142e-01	0.263	0	0
FLT3 signaling through SRC family kinases	R-HSA-9706374	5.460142e-01	0.263	0	0
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	6.020118e-01	0.220	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	6.068327e-01	0.217	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	4.378281e-01	0.359	0	0
Nephron development	R-HSA-9831926	3.587269e-01	0.445	0	0
Sensory processing of sound	R-HSA-9659379	5.928656e-01	0.227	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	6.219245e-01	0.206	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	6.054393e-01	0.218	0	0
Collagen chain trimerization	R-HSA-8948216	3.599586e-01	0.444	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	5.027380e-01	0.299	0	0
Toxicity of botulinum toxin type C (botC)	R-HSA-5250971	2.352525e-01	0.628	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	4.245022e-01	0.372	0	0
Interleukin-38 signaling	R-HSA-9007892	5.460142e-01	0.263	0	0
LGI-ADAM interactions	R-HSA-5682910	5.497271e-01	0.260	0	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	6.020118e-01	0.220	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	5.530182e-01	0.257	0	0
Growth hormone receptor signaling	R-HSA-982772	3.352587e-01	0.475	0	0
tRNA processing	R-HSA-72306	5.166953e-01	0.287	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	4.896238e-01	0.310	0	0
Regulation of TP53 Degradation	R-HSA-6804757	4.981645e-01	0.303	0	0
Nephrin family interactions	R-HSA-373753	4.174483e-01	0.379	0	0
Glucose metabolism	R-HSA-70326	2.105299e-01	0.677	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	4.563184e-01	0.341	0	0
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	6.020118e-01	0.220	0	0
Interleukin-37 signaling	R-HSA-9008059	5.124128e-01	0.290	0	0
Nectin/Necl trans heterodimerization	R-HSA-420597	6.020118e-01	0.220	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	6.045827e-01	0.219	0	0
Dissolution of Fibrin Clot	R-HSA-75205	5.497271e-01	0.260	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	6.223301e-01	0.206	0	0
Peptide chain elongation	R-HSA-156902	6.230483e-01	0.205	0	0
Selective autophagy	R-HSA-9663891	6.230483e-01	0.205	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	6.236692e-01	0.205	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	6.262066e-01	0.203	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	6.271757e-01	0.203	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	6.271757e-01	0.203	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	6.281748e-01	0.202	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	6.306026e-01	0.200	0	0
Signaling by BMP	R-HSA-201451	6.306796e-01	0.200	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	6.306796e-01	0.200	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	6.306796e-01	0.200	0	0
Signaling by NODAL	R-HSA-1181150	6.387149e-01	0.195	0	0
Creatine metabolism	R-HSA-71288	6.387149e-01	0.195	0	0
Protein hydroxylation	R-HSA-9629569	6.387149e-01	0.195	0	0
Ca-dependent events	R-HSA-111996	6.427626e-01	0.192	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	6.469505e-01	0.189	0	0
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	6.511051e-01	0.186	0	0
Nef Mediated CD8 Down-regulation	R-HSA-182218	6.511051e-01	0.186	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	6.511051e-01	0.186	0	0
PKB-mediated events	R-HSA-109703	6.511051e-01	0.186	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	6.511051e-01	0.186	0	0
PDE3B signalling	R-HSA-165160	6.511051e-01	0.186	0	0
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	6.511051e-01	0.186	0	0
Phosphorylation of Emi1	R-HSA-176417	6.511051e-01	0.186	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	6.511051e-01	0.186	0	0
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	6.511051e-01	0.186	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	6.511051e-01	0.186	0	0
Loss-of-function mutations in DBT cause MSUD2	R-HSA-9865113	6.511051e-01	0.186	0	0
Loss-of-function mutations in DLD cause MSUD3/DLDD	R-HSA-9907570	6.511051e-01	0.186	0	0
CLEC7A/inflammasome pathway	R-HSA-5660668	6.511051e-01	0.186	0	0
Ligand-receptor interactions	R-HSA-5632681	6.511051e-01	0.186	0	0
Orexin and neuropeptides FF and QRFP bind to their respective receptors	R-HSA-389397	6.511051e-01	0.186	0	0
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	6.511051e-01	0.186	0	0
Threonine catabolism	R-HSA-8849175	6.511051e-01	0.186	0	0
Diseases of Base Excision Repair	R-HSA-9605308	6.511051e-01	0.186	0	0
Sodium-coupled phosphate cotransporters	R-HSA-427652	6.511051e-01	0.186	0	0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	6.511051e-01	0.186	0	0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	6.511051e-01	0.186	0	0
Release of Hh-Np from the secreting cell	R-HSA-5362798	6.511051e-01	0.186	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	6.535760e-01	0.185	0	0
HIV elongation arrest and recovery	R-HSA-167287	6.535760e-01	0.185	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	6.535760e-01	0.185	0	0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	6.545232e-01	0.184	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	6.545232e-01	0.184	0	0
Membrane binding and targetting of GAG proteins	R-HSA-174490	6.545232e-01	0.184	0	0
Interleukin-6 signaling	R-HSA-1059683	6.545232e-01	0.184	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	6.546471e-01	0.184	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	6.546471e-01	0.184	0	0
HSF1-dependent transactivation	R-HSA-3371571	6.573572e-01	0.182	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	6.625322e-01	0.179	0	0
SHC-mediated cascade:FGFR3	R-HSA-5654704	6.645800e-01	0.177	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	6.645800e-01	0.177	0	0
UCH proteinases	R-HSA-5689603	6.658544e-01	0.177	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	6.669535e-01	0.176	0	0
GPVI-mediated activation cascade	R-HSA-114604	6.669535e-01	0.176	0	0
Calmodulin induced events	R-HSA-111933	6.669535e-01	0.176	0	0
CaM pathway	R-HSA-111997	6.669535e-01	0.176	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	6.678112e-01	0.175	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	6.734864e-01	0.172	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	6.741301e-01	0.171	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	6.741301e-01	0.171	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	6.755007e-01	0.170	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	6.755007e-01	0.170	0	0
Platelet calcium homeostasis	R-HSA-418360	6.755007e-01	0.170	0	0
Autophagy	R-HSA-9612973	6.835294e-01	0.165	0	0
Macroautophagy	R-HSA-1632852	6.835540e-01	0.165	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	6.848353e-01	0.164	0	0
CRMPs in Sema3A signaling	R-HSA-399956	6.848353e-01	0.164	0	0
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	6.848353e-01	0.164	0	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	6.848353e-01	0.164	0	0
cGMP effects	R-HSA-418457	6.848353e-01	0.164	0	0
Signal regulatory protein family interactions	R-HSA-391160	6.848353e-01	0.164	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	6.858721e-01	0.164	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	6.861993e-01	0.164	0	0
Adherens junctions interactions	R-HSA-418990	6.863338e-01	0.163	0	0
Eukaryotic Translation Elongation	R-HSA-156842	6.889716e-01	0.162	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	6.890692e-01	0.162	0	0
SHC-mediated cascade:FGFR4	R-HSA-5654719	6.890692e-01	0.162	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	6.890692e-01	0.162	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	6.890692e-01	0.162	0	0
Meiotic synapsis	R-HSA-1221632	6.903807e-01	0.161	0	0
Signaling by LTK in cancer	R-HSA-9842640	6.941451e-01	0.159	0	0
STAT5 Activation	R-HSA-9645135	6.941451e-01	0.159	0	0
Erythropoietin activates STAT5	R-HSA-9027283	6.941451e-01	0.159	0	0
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	6.941451e-01	0.159	0	0
Autointegration results in viral DNA circles	R-HSA-177539	6.941451e-01	0.159	0	0
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	6.941451e-01	0.159	0	0
Defective CHST3 causes SEDCJD	R-HSA-3595172	6.941451e-01	0.159	0	0
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	6.941451e-01	0.159	0	0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD	R-HSA-9865125	6.941451e-01	0.159	0	0
MET Receptor Activation	R-HSA-6806942	6.941451e-01	0.159	0	0
Intracellular metabolism of fatty acids regulates insulin secretion	R-HSA-434313	6.941451e-01	0.159	0	0
Integration of viral DNA into host genomic DNA	R-HSA-175567	6.941451e-01	0.159	0	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	6.941451e-01	0.159	0	0
CREB3 factors activate genes	R-HSA-8874211	6.941451e-01	0.159	0	0
Defective factor VIII causes hemophilia A	R-HSA-9662001	6.941451e-01	0.159	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	6.964149e-01	0.157	0	0
Nucleosome assembly	R-HSA-774815	6.964149e-01	0.157	0	0
DAG and IP3 signaling	R-HSA-1489509	6.964149e-01	0.157	0	0
Synthesis of DNA	R-HSA-69239	6.977335e-01	0.156	0	0
Cellular response to starvation	R-HSA-9711097	7.025846e-01	0.153	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	7.060992e-01	0.151	0	0
FGFR2 alternative splicing	R-HSA-6803529	7.121895e-01	0.147	0	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.121895e-01	0.147	0	0
Signaling by KIT in disease	R-HSA-9669938	7.121895e-01	0.147	0	0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	7.129288e-01	0.147	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	7.129288e-01	0.147	0	0
G beta:gamma signalling through BTK	R-HSA-8964315	7.129288e-01	0.147	0	0
Signaling by Activin	R-HSA-1502540	7.129288e-01	0.147	0	0
Telomere C-strand synthesis initiation	R-HSA-174430	7.129288e-01	0.147	0	0
Protein lipoylation	R-HSA-9857492	7.129288e-01	0.147	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	7.129288e-01	0.147	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	7.129288e-01	0.147	0	0
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	7.129288e-01	0.147	0	0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	7.129288e-01	0.147	0	0
FASTK family proteins regulate processing and stability of mitochondrial RNAs	R-HSA-9837092	7.129288e-01	0.147	0	0
Biotin transport and metabolism	R-HSA-196780	7.129288e-01	0.147	0	0
Collagen formation	R-HSA-1474290	7.133151e-01	0.147	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	7.152682e-01	0.146	0	0
Trafficking of AMPA receptors	R-HSA-399719	7.163961e-01	0.145	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	7.163961e-01	0.145	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	7.163961e-01	0.145	0	0
Toll-like Receptor Cascades	R-HSA-168898	7.190390e-01	0.143	1	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	7.250278e-01	0.140	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	7.290431e-01	0.137	0	0
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	7.318779e-01	0.136	0	0
Defective CHSY1 causes TPBS	R-HSA-3595177	7.318779e-01	0.136	0	0
Recycling of eIF2:GDP	R-HSA-72731	7.318779e-01	0.136	0	0
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	7.318779e-01	0.136	0	0
Phase 3 - rapid repolarisation	R-HSA-5576890	7.318779e-01	0.136	0	0
Netrin mediated repulsion signals	R-HSA-418886	7.318779e-01	0.136	0	0
Cysteine formation from homocysteine	R-HSA-1614603	7.318779e-01	0.136	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	7.318779e-01	0.136	0	0
VLDL clearance	R-HSA-8964046	7.318779e-01	0.136	0	0
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	7.318779e-01	0.136	0	0
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	7.318779e-01	0.136	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	7.318779e-01	0.136	0	0
CHL1 interactions	R-HSA-447041	7.318779e-01	0.136	0	0
Activated NTRK2 signals through CDK5	R-HSA-9032845	7.318779e-01	0.136	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	7.318779e-01	0.136	0	0
Maturation of replicase proteins	R-HSA-9694301	7.318779e-01	0.136	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	7.334097e-01	0.135	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	7.339596e-01	0.134	0	0
Carnitine shuttle	R-HSA-200425	7.339596e-01	0.134	0	0
Syndecan interactions	R-HSA-3000170	7.339596e-01	0.134	0	0
Signaling by WNT in cancer	R-HSA-4791275	7.353667e-01	0.133	0	0
TNF signaling	R-HSA-75893	7.359158e-01	0.133	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	7.364292e-01	0.133	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	7.364292e-01	0.133	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	7.369593e-01	0.133	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	7.388897e-01	0.131	0	0
Phosphorylation of the APC/C	R-HSA-176412	7.388897e-01	0.131	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	7.388897e-01	0.131	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	7.393129e-01	0.131	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	7.441594e-01	0.128	0	0
GPER1 signaling	R-HSA-9634597	7.444000e-01	0.128	0	0
Co-stimulation by CD28	R-HSA-389356	7.444000e-01	0.128	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	7.460619e-01	0.127	0	0
COPI-mediated anterograde transport	R-HSA-6807878	7.475164e-01	0.126	0	0
IRS-mediated signalling	R-HSA-112399	7.500079e-01	0.125	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	7.533638e-01	0.123	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	7.533638e-01	0.123	0	0
SHC-mediated cascade:FGFR1	R-HSA-5654688	7.544076e-01	0.122	0	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	7.544076e-01	0.122	0	0
Interleukin-6 family signaling	R-HSA-6783589	7.544076e-01	0.122	0	0
Mitochondrial RNA degradation	R-HSA-9836573	7.544076e-01	0.122	0	0
Cell-cell junction organization	R-HSA-421270	7.545805e-01	0.122	0	0
DNA Damage Bypass	R-HSA-73893	7.591196e-01	0.120	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	7.591196e-01	0.120	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	7.591196e-01	0.120	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	7.606496e-01	0.119	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	7.614648e-01	0.118	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	7.625376e-01	0.118	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	7.628164e-01	0.118	0	0
Transcriptional regulation of testis differentiation	R-HSA-9690406	7.628164e-01	0.118	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	7.628164e-01	0.118	0	0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	7.628164e-01	0.118	0	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	7.649575e-01	0.116	0	0
phospho-PLA2 pathway	R-HSA-111995	7.649575e-01	0.116	0	0
Activated NTRK2 signals through PI3K	R-HSA-9028335	7.649575e-01	0.116	0	0
Activation of RAS in B cells	R-HSA-1169092	7.649575e-01	0.116	0	0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	7.649575e-01	0.116	0	0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	7.649575e-01	0.116	0	0
Axonal growth inhibition (RHOA activation)	R-HSA-193634	7.649575e-01	0.116	0	0
Interleukin-9 signaling	R-HSA-8985947	7.649575e-01	0.116	0	0
TGFBR3 PTM regulation	R-HSA-9839383	7.649575e-01	0.116	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	7.649575e-01	0.116	0	0
Calcitonin-like ligand receptors	R-HSA-419812	7.649575e-01	0.116	0	0
Activated NTRK2 signals through FYN	R-HSA-9032500	7.649575e-01	0.116	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	7.649575e-01	0.116	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	7.649575e-01	0.116	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	7.649575e-01	0.116	0	0
HCMV Late Events	R-HSA-9610379	7.654432e-01	0.116	0	0
Kidney development	R-HSA-9830369	7.683996e-01	0.114	0	0
Signaling by FGFR	R-HSA-190236	7.687421e-01	0.114	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	7.711434e-01	0.113	0	0
Regulation of RAS by GAPs	R-HSA-5658442	7.732063e-01	0.112	0	0
PI3K Cascade	R-HSA-109704	7.732063e-01	0.112	0	0
Interleukin-12 signaling	R-HSA-9020591	7.734374e-01	0.112	0	0
G protein gated Potassium channels	R-HSA-1296059	7.735696e-01	0.112	0	0
Activation of G protein gated Potassium channels	R-HSA-1296041	7.735696e-01	0.112	0	0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	7.735696e-01	0.112	0	0
Tight junction interactions	R-HSA-420029	7.735696e-01	0.112	0	0
Acyl chain remodelling of PS	R-HSA-1482801	7.735696e-01	0.112	0	0
Formation of the nephric duct	R-HSA-9830364	7.735696e-01	0.112	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	7.843543e-01	0.105	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	7.848158e-01	0.105	0	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	7.848158e-01	0.105	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	7.848158e-01	0.105	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	7.848158e-01	0.105	0	0
Specification of primordial germ cells	R-HSA-9827857	7.848158e-01	0.105	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	7.855195e-01	0.105	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	7.865027e-01	0.104	0	0
Dual Incision in GG-NER	R-HSA-5696400	7.865027e-01	0.104	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	7.865027e-01	0.104	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	7.865027e-01	0.104	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	7.890328e-01	0.103	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	7.896830e-01	0.103	0	0
Metalloprotease DUBs	R-HSA-5689901	7.914877e-01	0.102	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	7.914877e-01	0.102	0	0
MAPK1 (ERK2) activation	R-HSA-112411	7.939576e-01	0.100	0	0
ALK mutants bind TKIs	R-HSA-9700645	7.939576e-01	0.100	0	0
GP1b-IX-V activation signalling	R-HSA-430116	7.939576e-01	0.100	0	0
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	7.939576e-01	0.100	0	0
MASTL Facilitates Mitotic Progression	R-HSA-2465910	7.939576e-01	0.100	0	0
Unwinding of DNA	R-HSA-176974	7.939576e-01	0.100	0	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	7.939576e-01	0.100	0	0
p75NTR regulates axonogenesis	R-HSA-193697	7.939576e-01	0.100	0	0
Regulation of signaling by NODAL	R-HSA-1433617	7.939576e-01	0.100	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	7.939576e-01	0.100	0	0
WNT mediated activation of DVL	R-HSA-201688	7.939576e-01	0.100	0	0
Regulation of NPAS4 gene transcription	R-HSA-9768777	7.939576e-01	0.100	0	0
Interleukin-1 processing	R-HSA-448706	7.939576e-01	0.100	0	0
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	7.939576e-01	0.100	0	0
Lysosomal oligosaccharide catabolism	R-HSA-8853383	7.939576e-01	0.100	0	0
Defects in biotin (Btn) metabolism	R-HSA-3323169	7.939576e-01	0.100	0	0
Butyrophilin (BTN) family interactions	R-HSA-8851680	7.939576e-01	0.100	0	0
PCP/CE pathway	R-HSA-4086400	7.956535e-01	0.099	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	7.972776e-01	0.098	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	7.994289e-01	0.097	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	7.994441e-01	0.097	0	0
Orc1 removal from chromatin	R-HSA-68949	7.995099e-01	0.097	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	7.995099e-01	0.097	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	8.009724e-01	0.096	0	0
Formation of paraxial mesoderm	R-HSA-9793380	8.009724e-01	0.096	0	0
Regulation of Apoptosis	R-HSA-169911	8.016882e-01	0.096	0	0
COPII-mediated vesicle transport	R-HSA-204005	8.032868e-01	0.095	0	0
Ribosome-associated quality control	R-HSA-9948299	8.047748e-01	0.094	0	0
G beta:gamma signalling through PLC beta	R-HSA-418217	8.049990e-01	0.094	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	8.049990e-01	0.094	0	0
Presynaptic function of Kainate receptors	R-HSA-500657	8.049990e-01	0.094	0	0
Vitamin D (calciferol) metabolism	R-HSA-196791	8.049990e-01	0.094	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	8.082087e-01	0.092	0	0
SHC-mediated cascade:FGFR2	R-HSA-5654699	8.082087e-01	0.092	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	8.082087e-01	0.092	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	8.082087e-01	0.092	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	8.082087e-01	0.092	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	8.082087e-01	0.092	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	8.082087e-01	0.092	0	0
Insulin processing	R-HSA-264876	8.082087e-01	0.092	0	0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	8.082087e-01	0.092	0	0
Chaperonin-mediated protein folding	R-HSA-390466	8.093327e-01	0.092	0	0
Interleukin-12 family signaling	R-HSA-447115	8.093327e-01	0.092	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	8.117466e-01	0.091	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	8.117466e-01	0.091	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	8.117466e-01	0.091	0	0
Amine ligand-binding receptors	R-HSA-375280	8.126169e-01	0.090	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	8.139904e-01	0.089	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	8.162155e-01	0.088	0	0
HCMV Early Events	R-HSA-9609690	8.165735e-01	0.088	0	0
MAPK3 (ERK1) activation	R-HSA-110056	8.193811e-01	0.087	0	0
DNA replication initiation	R-HSA-68952	8.193811e-01	0.087	0	0
Folding of actin by CCT/TriC	R-HSA-390450	8.193811e-01	0.087	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	8.193811e-01	0.087	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	8.193811e-01	0.087	0	0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	8.193811e-01	0.087	0	0
Regulation of CDH11 function	R-HSA-9762292	8.193811e-01	0.087	0	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	8.193811e-01	0.087	0	0
2-LTR circle formation	R-HSA-164843	8.193811e-01	0.087	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	8.193811e-01	0.087	0	0
Interleukin-27 signaling	R-HSA-9020956	8.193811e-01	0.087	0	0
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	8.193811e-01	0.087	0	0
Sperm Motility And Taxes	R-HSA-1300642	8.193811e-01	0.087	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	8.193811e-01	0.087	0	0
Josephin domain DUBs	R-HSA-5689877	8.193811e-01	0.087	0	0
Serotonin receptors	R-HSA-390666	8.193811e-01	0.087	0	0
Leishmania phagocytosis	R-HSA-9664417	8.199961e-01	0.086	0	0
Parasite infection	R-HSA-9664407	8.199961e-01	0.086	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	8.199961e-01	0.086	0	0
Eukaryotic Translation Termination	R-HSA-72764	8.217621e-01	0.085	0	0
Pre-NOTCH Processing in Golgi	R-HSA-1912420	8.234793e-01	0.084	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	8.234793e-01	0.084	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	8.234793e-01	0.084	0	0
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	8.234793e-01	0.084	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	8.234793e-01	0.084	0	0
Specification of the neural plate border	R-HSA-9834899	8.234793e-01	0.084	0	0
Diseases of hemostasis	R-HSA-9671793	8.234793e-01	0.084	0	0
The NLRP3 inflammasome	R-HSA-844456	8.234793e-01	0.084	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	8.237829e-01	0.084	0	0
Formation of the Early Elongation Complex	R-HSA-113418	8.237829e-01	0.084	0	0
Pyrimidine salvage	R-HSA-73614	8.237829e-01	0.084	0	0
Inflammasomes	R-HSA-622312	8.237829e-01	0.084	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	8.251021e-01	0.083	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	8.251021e-01	0.083	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	8.251021e-01	0.083	0	0
Developmental Cell Lineages	R-HSA-9734767	8.282249e-01	0.082	0	0
Ub-specific processing proteases	R-HSA-5689880	8.294718e-01	0.081	0	0
HDACs deacetylate histones	R-HSA-3214815	8.344529e-01	0.079	0	0
Base Excision Repair	R-HSA-73884	8.368063e-01	0.077	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	8.369045e-01	0.077	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	8.369045e-01	0.077	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	8.369045e-01	0.077	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	8.369045e-01	0.077	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	8.382630e-01	0.077	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	8.382630e-01	0.077	0	0
Regulation of PD-L1(CD274) translation	R-HSA-9909620	8.403695e-01	0.076	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	8.403695e-01	0.076	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	8.403695e-01	0.076	0	0
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	8.403695e-01	0.076	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	8.410394e-01	0.075	0	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	8.416689e-01	0.075	0	0
Signaling by APC mutants	R-HSA-4839744	8.416689e-01	0.075	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	8.416689e-01	0.075	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	8.416689e-01	0.075	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	8.416689e-01	0.075	0	0
vRNA Synthesis	R-HSA-192814	8.416689e-01	0.075	0	0
vRNP Assembly	R-HSA-192905	8.416689e-01	0.075	0	0
Transport of RCbl within the body	R-HSA-9758890	8.416689e-01	0.075	0	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	8.416689e-01	0.075	0	0
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	8.416689e-01	0.075	0	0
Synthesis of PIPs at the ER membrane	R-HSA-1483248	8.416689e-01	0.075	0	0
SARS-CoV-2 modulates autophagy	R-HSA-9754560	8.416689e-01	0.075	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	8.449519e-01	0.073	0	0
Ion homeostasis	R-HSA-5578775	8.449519e-01	0.073	0	0
Chromosome Maintenance	R-HSA-73886	8.461114e-01	0.073	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	8.508011e-01	0.070	0	0
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	8.517032e-01	0.070	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	8.525587e-01	0.069	0	0
IRE1alpha activates chaperones	R-HSA-381070	8.533515e-01	0.069	0	0
Stabilization of p53	R-HSA-69541	8.538562e-01	0.069	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	8.557806e-01	0.068	0	0
G-protein activation	R-HSA-202040	8.557806e-01	0.068	0	0
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	8.557806e-01	0.068	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	8.557806e-01	0.068	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	8.557806e-01	0.068	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	8.557806e-01	0.068	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	8.609064e-01	0.065	0	0
Protein folding	R-HSA-391251	8.611128e-01	0.065	0	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	8.612076e-01	0.065	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	8.612076e-01	0.065	0	0
Endosomal/Vacuolar pathway	R-HSA-1236977	8.612076e-01	0.065	0	0
Integration of provirus	R-HSA-162592	8.612076e-01	0.065	0	0
NF-kB is activated and signals survival	R-HSA-209560	8.612076e-01	0.065	0	0
Plasmalogen biosynthesis	R-HSA-75896	8.612076e-01	0.065	0	0
Signaling by AXIN mutants	R-HSA-4839735	8.612076e-01	0.065	0	0
Signaling by AMER1 mutants	R-HSA-4839748	8.612076e-01	0.065	0	0
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	8.612076e-01	0.065	0	0
Anchoring fibril formation	R-HSA-2214320	8.612076e-01	0.065	0	0
Reproduction	R-HSA-1474165	8.619953e-01	0.064	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	8.641582e-01	0.063	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	8.641582e-01	0.063	0	0
Cargo concentration in the ER	R-HSA-5694530	8.641582e-01	0.063	0	0
Budding and maturation of HIV virion	R-HSA-162588	8.641582e-01	0.063	0	0
Attenuation phase	R-HSA-3371568	8.649143e-01	0.063	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	8.649143e-01	0.063	0	0
Generation of second messenger molecules	R-HSA-202433	8.649143e-01	0.063	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	8.649143e-01	0.063	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	8.678392e-01	0.062	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	8.684612e-01	0.061	0	0
Assembly of the pre-replicative complex	R-HSA-68867	8.685432e-01	0.061	0	0
Selenocysteine synthesis	R-HSA-2408557	8.691150e-01	0.061	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	8.698203e-01	0.061	0	0
FRS-mediated FGFR3 signaling	R-HSA-5654706	8.698203e-01	0.061	0	0
Assembly Of The HIV Virion	R-HSA-175474	8.698203e-01	0.061	0	0
DNA Replication Pre-Initiation	R-HSA-69002	8.700555e-01	0.060	0	0
Extension of Telomeres	R-HSA-180786	8.732301e-01	0.059	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	8.752467e-01	0.058	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	8.752467e-01	0.058	0	0
Inwardly rectifying K+ channels	R-HSA-1296065	8.756828e-01	0.058	0	0
RNA Polymerase I Transcription	R-HSA-73864	8.767752e-01	0.057	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	8.777359e-01	0.057	0	0
IRAK1 recruits IKK complex	R-HSA-937039	8.783361e-01	0.056	0	0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	8.783361e-01	0.056	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	8.783361e-01	0.056	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	8.783361e-01	0.056	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	8.783361e-01	0.056	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	8.783361e-01	0.056	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	8.783361e-01	0.056	0	0
Role of second messengers in netrin-1 signaling	R-HSA-418890	8.783361e-01	0.056	0	0
Serotonin clearance from the synaptic cleft	R-HSA-380615	8.783361e-01	0.056	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	8.783361e-01	0.056	0	0
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	8.783361e-01	0.056	0	0
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	8.783361e-01	0.056	0	0
Kinesins	R-HSA-983189	8.816426e-01	0.055	0	0
Viral mRNA Translation	R-HSA-192823	8.824609e-01	0.054	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	8.825923e-01	0.054	0	0
FRS-mediated FGFR4 signaling	R-HSA-5654712	8.825923e-01	0.054	0	0
LDL clearance	R-HSA-8964038	8.825923e-01	0.054	0	0
Neurotoxicity of clostridium toxins	R-HSA-168799	8.825923e-01	0.054	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	8.835882e-01	0.054	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	8.848881e-01	0.053	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	8.862341e-01	0.052	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	8.862341e-01	0.052	0	0
G-protein beta:gamma signalling	R-HSA-397795	8.863313e-01	0.052	0	0
Regulation of necroptotic cell death	R-HSA-5675482	8.863313e-01	0.052	0	0
Recycling of bile acids and salts	R-HSA-159418	8.863313e-01	0.052	0	0
Meiotic recombination	R-HSA-912446	8.864683e-01	0.052	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	8.887075e-01	0.051	0	0
PLC beta mediated events	R-HSA-112043	8.895793e-01	0.051	0	0
Diseases of programmed cell death	R-HSA-9645723	8.896820e-01	0.051	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	8.911230e-01	0.050	0	0
Platelet Adhesion to exposed collagen	R-HSA-75892	8.933516e-01	0.049	0	0
IL-6-type cytokine receptor ligand interactions	R-HSA-6788467	8.933516e-01	0.049	0	0
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	8.933516e-01	0.049	0	0
Replication of the SARS-CoV-1 genome	R-HSA-9682706	8.933516e-01	0.049	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	8.934764e-01	0.049	0	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	8.938730e-01	0.049	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	8.941957e-01	0.049	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	8.941957e-01	0.049	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	8.941957e-01	0.049	0	0
ABC transporters in lipid homeostasis	R-HSA-1369062	8.941957e-01	0.049	0	0
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	8.941957e-01	0.049	0	0
Mitochondrial mRNA modification	R-HSA-9937008	8.941957e-01	0.049	0	0
RSV-host interactions	R-HSA-9833110	8.946799e-01	0.048	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	8.951199e-01	0.048	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	8.961569e-01	0.048	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	8.961569e-01	0.048	0	0
Glutamate and glutamine metabolism	R-HSA-8964539	8.961569e-01	0.048	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	8.970588e-01	0.047	0	0
Synthesis of very long-chain fatty acyl-CoAs	R-HSA-75876	9.022360e-01	0.045	0	0
Amino acids regulate mTORC1	R-HSA-9639288	9.023349e-01	0.045	0	0
DNA Replication	R-HSA-69306	9.029762e-01	0.044	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	9.041004e-01	0.044	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	9.047243e-01	0.043	0	0
Thromboxane signalling through TP receptor	R-HSA-428930	9.047243e-01	0.043	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	9.047243e-01	0.043	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	9.047243e-01	0.043	0	0
Complex III assembly	R-HSA-9865881	9.047243e-01	0.043	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	9.052115e-01	0.043	0	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.052115e-01	0.043	0	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.052115e-01	0.043	0	0
Signal amplification	R-HSA-392518	9.052115e-01	0.043	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	9.052115e-01	0.043	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	9.058331e-01	0.043	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.060694e-01	0.043	0	0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV	R-HSA-9859138	9.065148e-01	0.043	0	0
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	9.065148e-01	0.043	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	9.065148e-01	0.043	0	0
Hydrolysis of LPC	R-HSA-1483115	9.065148e-01	0.043	0	0
Physiological factors	R-HSA-5578768	9.065148e-01	0.043	0	0
Prolactin receptor signaling	R-HSA-1170546	9.065148e-01	0.043	0	0
Respiratory syncytial virus genome transcription	R-HSA-9828642	9.065148e-01	0.043	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	9.065148e-01	0.043	0	0
Malate-aspartate shuttle	R-HSA-9856872	9.065148e-01	0.043	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	9.065148e-01	0.043	0	0
HDL assembly	R-HSA-8963896	9.065148e-01	0.043	0	0
Acyl chain remodeling of CL	R-HSA-1482798	9.065148e-01	0.043	0	0
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	9.065148e-01	0.043	0	0
SARS-CoV-2 Infection	R-HSA-9694516	9.089469e-01	0.041	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	9.095184e-01	0.041	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	9.100108e-01	0.041	0	0
RMTs methylate histone arginines	R-HSA-3214858	9.100108e-01	0.041	0	0
Signaling by Hedgehog	R-HSA-5358351	9.106620e-01	0.041	0	0
Ion transport by P-type ATPases	R-HSA-936837	9.107227e-01	0.041	0	0
Signaling by NOTCH4	R-HSA-9013694	9.129036e-01	0.040	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	9.135454e-01	0.039	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	9.142665e-01	0.039	0	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	9.142665e-01	0.039	0	0
Laminin interactions	R-HSA-3000157	9.142665e-01	0.039	0	0
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.142665e-01	0.039	0	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.142665e-01	0.039	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.172306e-01	0.038	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	9.180539e-01	0.037	0	0
RNA Polymerase III Chain Elongation	R-HSA-73780	9.180539e-01	0.037	0	0
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	9.180539e-01	0.037	0	0
Translesion synthesis by REV1	R-HSA-110312	9.180539e-01	0.037	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	9.180539e-01	0.037	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	9.180539e-01	0.037	0	0
Other semaphorin interactions	R-HSA-416700	9.180539e-01	0.037	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	9.186634e-01	0.037	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	9.186634e-01	0.037	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.186634e-01	0.037	0	0
Signaling by Insulin receptor	R-HSA-74752	9.187057e-01	0.037	0	0
HSF1 activation	R-HSA-3371511	9.212070e-01	0.036	0	0
Glycosphingolipid transport	R-HSA-9845576	9.212070e-01	0.036	0	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.229055e-01	0.035	0	0
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	9.229055e-01	0.035	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	9.229055e-01	0.035	0	0
Suppression of phagosomal maturation	R-HSA-9637687	9.229055e-01	0.035	0	0
SLC transporter disorders	R-HSA-5619102	9.241538e-01	0.034	0	0
Regulation of endogenous retroelements	R-HSA-9842860	9.265162e-01	0.033	0	0
Translesion synthesis by POLI	R-HSA-5656121	9.281693e-01	0.032	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	9.281693e-01	0.032	0	0
Phase 4 - resting membrane potential	R-HSA-5576886	9.281693e-01	0.032	0	0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	9.281693e-01	0.032	0	0
Fructose catabolism	R-HSA-70350	9.281693e-01	0.032	0	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	9.281693e-01	0.032	0	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	9.281693e-01	0.032	0	0
Attachment and Entry	R-HSA-9678110	9.281693e-01	0.032	0	0
Voltage gated Potassium channels	R-HSA-1296072	9.282425e-01	0.032	0	0
Degradation of DVL	R-HSA-4641258	9.282425e-01	0.032	0	0
G-protein mediated events	R-HSA-112040	9.282620e-01	0.032	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	9.301332e-01	0.031	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	9.307187e-01	0.031	0	0
Cristae formation	R-HSA-8949613	9.307187e-01	0.031	0	0
Synthesis of PE	R-HSA-1483213	9.307187e-01	0.031	0	0
Maturation of hRSV A proteins	R-HSA-9828806	9.307187e-01	0.031	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	9.333933e-01	0.030	0	0
Muscle contraction	R-HSA-397014	9.336977e-01	0.030	0	0
Dual incision in TC-NER	R-HSA-6782135	9.338162e-01	0.030	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	9.346964e-01	0.029	0	0
Translesion synthesis by POLK	R-HSA-5655862	9.370366e-01	0.028	0	0
Defective B3GALT6 causes EDSP2 and SEMDJL1	R-HSA-4420332	9.370366e-01	0.028	0	0
Defective B4GALT7 causes EDS, progeroid type	R-HSA-3560783	9.370366e-01	0.028	0	0
Glycine degradation	R-HSA-6783984	9.370366e-01	0.028	0	0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	9.370366e-01	0.028	0	0
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	9.370366e-01	0.028	0	0
Fibronectin matrix formation	R-HSA-1566977	9.370366e-01	0.028	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	9.370366e-01	0.028	0	0
Synthesis of PG	R-HSA-1483148	9.370366e-01	0.028	0	0
tRNA modification in the mitochondrion	R-HSA-6787450	9.370366e-01	0.028	0	0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	9.370366e-01	0.028	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	9.377784e-01	0.028	0	0
FRS-mediated FGFR2 signaling	R-HSA-5654700	9.377784e-01	0.028	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.377784e-01	0.028	0	0
Peroxisomal protein import	R-HSA-9033241	9.388970e-01	0.027	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	9.398341e-01	0.027	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	9.406107e-01	0.027	0	0
Plasma lipoprotein clearance	R-HSA-8964043	9.406107e-01	0.027	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.406107e-01	0.027	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	9.409374e-01	0.026	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.426894e-01	0.026	0	0
mRNA Capping	R-HSA-72086	9.441514e-01	0.025	0	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	9.441514e-01	0.025	0	0
Glucagon-type ligand receptors	R-HSA-420092	9.441514e-01	0.025	0	0
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	9.448097e-01	0.025	0	0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	9.448097e-01	0.025	0	0
Defective B3GAT3 causes JDSSDHD	R-HSA-3560801	9.448097e-01	0.025	0	0
Catecholamine biosynthesis	R-HSA-209905	9.448097e-01	0.025	0	0
GDP-fucose biosynthesis	R-HSA-6787639	9.448097e-01	0.025	0	0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	9.448097e-01	0.025	0	0
Glycogen storage diseases	R-HSA-3229121	9.448097e-01	0.025	0	0
Replication of the SARS-CoV-2 genome	R-HSA-9694686	9.448097e-01	0.025	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	9.460251e-01	0.024	0	0
HIV Transcription Elongation	R-HSA-167169	9.460251e-01	0.024	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	9.460251e-01	0.024	0	0
Platelet homeostasis	R-HSA-418346	9.461600e-01	0.024	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	9.465179e-01	0.024	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	9.468876e-01	0.024	0	0
Regulation of mitotic cell cycle	R-HSA-453276	9.468876e-01	0.024	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.498997e-01	0.022	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	9.506274e-01	0.022	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	9.509774e-01	0.022	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	9.509774e-01	0.022	0	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.509774e-01	0.022	0	0
Vesicle-mediated transport	R-HSA-5653656	9.512848e-01	0.022	0	0
PKA activation	R-HSA-163615	9.516236e-01	0.022	0	0
Transport of connexons to the plasma membrane	R-HSA-190872	9.516236e-01	0.022	0	0
PKA activation in glucagon signalling	R-HSA-164378	9.516236e-01	0.022	0	0
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	9.516236e-01	0.022	0	0
Platelet sensitization by LDL	R-HSA-432142	9.516236e-01	0.022	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	9.521003e-01	0.021	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.548051e-01	0.020	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	9.548051e-01	0.020	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	9.548051e-01	0.020	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	9.555029e-01	0.020	0	0
Heme biosynthesis	R-HSA-189451	9.555029e-01	0.020	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	9.560361e-01	0.020	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	9.572370e-01	0.019	0	0
Crosslinking of collagen fibrils	R-HSA-2243919	9.575965e-01	0.019	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	9.575965e-01	0.019	0	0
Pyrimidine biosynthesis	R-HSA-500753	9.575965e-01	0.019	0	0
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	9.575965e-01	0.019	0	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	9.575965e-01	0.019	0	0
Translesion Synthesis by POLH	R-HSA-110320	9.575965e-01	0.019	0	0
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	9.575965e-01	0.019	0	0
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	9.575965e-01	0.019	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	9.576468e-01	0.019	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	9.586546e-01	0.018	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	9.586546e-01	0.018	0	0
Nucleotide biosynthesis	R-HSA-8956320	9.586546e-01	0.018	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	9.596348e-01	0.018	0	0
Activation of GABAB receptors	R-HSA-991365	9.596348e-01	0.018	0	0
GABA B receptor activation	R-HSA-977444	9.596348e-01	0.018	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	9.597459e-01	0.018	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.597459e-01	0.018	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.599676e-01	0.018	0	0
rRNA processing	R-HSA-72312	9.602399e-01	0.018	0	0
HCMV Infection	R-HSA-9609646	9.605823e-01	0.017	0	0
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.628323e-01	0.016	0	0
Formation of ATP by chemiosmotic coupling	R-HSA-163210	9.628323e-01	0.016	0	0
Co-inhibition by CTLA4	R-HSA-389513	9.628323e-01	0.016	0	0
Wax and plasmalogen biosynthesis	R-HSA-8848584	9.628323e-01	0.016	0	0
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	9.628323e-01	0.016	0	0
Acyl chain remodelling of PI	R-HSA-1482922	9.628323e-01	0.016	0	0
Glycogen synthesis	R-HSA-3322077	9.628323e-01	0.016	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.634043e-01	0.016	0	0
FCERI mediated MAPK activation	R-HSA-2871796	9.635313e-01	0.016	0	0
Integration of energy metabolism	R-HSA-163685	9.639209e-01	0.016	0	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	9.639445e-01	0.016	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	9.654590e-01	0.015	0	0
G alpha (z) signalling events	R-HSA-418597	9.654590e-01	0.015	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	9.674219e-01	0.014	0	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	9.674219e-01	0.014	0	0
Vitamin C (ascorbate) metabolism	R-HSA-196836	9.674219e-01	0.014	0	0
Basigin interactions	R-HSA-210991	9.674219e-01	0.014	0	0
Acyl chain remodelling of PG	R-HSA-1482925	9.674219e-01	0.014	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	9.677203e-01	0.014	0	0
Acyl chain remodelling of PC	R-HSA-1482788	9.677203e-01	0.014	0	0
Vpu mediated degradation of CD4	R-HSA-180534	9.677203e-01	0.014	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.677203e-01	0.014	0	0
Pyruvate metabolism	R-HSA-70268	9.683275e-01	0.014	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	9.684560e-01	0.014	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	9.692503e-01	0.014	0	0
Interleukin-10 signaling	R-HSA-6783783	9.693140e-01	0.014	0	0
Fanconi Anemia Pathway	R-HSA-6783310	9.699703e-01	0.013	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.699703e-01	0.013	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.699703e-01	0.013	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.699703e-01	0.013	0	0
Somitogenesis	R-HSA-9824272	9.699703e-01	0.013	0	0
Nucleotide Excision Repair	R-HSA-5696398	9.700114e-01	0.013	0	0
MHC class II antigen presentation	R-HSA-2132295	9.705536e-01	0.013	0	0
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.711137e-01	0.013	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	9.711137e-01	0.013	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	9.711137e-01	0.013	0	0
CS-GAG biosynthesis	R-HSA-2022870	9.714450e-01	0.013	0	0
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	9.714450e-01	0.013	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	9.714450e-01	0.013	0	0
Attachment and Entry	R-HSA-9694614	9.714450e-01	0.013	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.716886e-01	0.012	0	0
Telomere Maintenance	R-HSA-157579	9.722516e-01	0.012	0	0
Regulation of pyruvate metabolism	R-HSA-9861718	9.728191e-01	0.012	0	0
PKR-mediated signaling	R-HSA-9833482	9.738927e-01	0.011	0	0
Potential therapeutics for SARS	R-HSA-9679191	9.741182e-01	0.011	0	0
Acyl chain remodelling of PE	R-HSA-1482839	9.741615e-01	0.011	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	9.741615e-01	0.011	0	0
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.741615e-01	0.011	0	0
Cellular response to chemical stress	R-HSA-9711123	9.741799e-01	0.011	0	0
Neurotransmitter release cycle	R-HSA-112310	9.748480e-01	0.011	0	0
Fructose metabolism	R-HSA-5652084	9.749714e-01	0.011	0	0
Ethanol oxidation	R-HSA-71384	9.749714e-01	0.011	0	0
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.749714e-01	0.011	0	0
Cellular hexose transport	R-HSA-189200	9.749714e-01	0.011	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	9.749714e-01	0.011	0	0
Interferon Signaling	R-HSA-913531	9.752220e-01	0.011	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	9.754102e-01	0.011	0	0
PRC2 methylates histones and DNA	R-HSA-212300	9.768973e-01	0.010	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	9.768973e-01	0.010	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	9.768973e-01	0.010	0	0
Triglyceride catabolism	R-HSA-163560	9.768973e-01	0.010	0	0
Hedgehog 'off' state	R-HSA-5610787	9.777955e-01	0.010	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	9.780626e-01	0.010	0	0
Free fatty acids regulate insulin secretion	R-HSA-400451	9.780626e-01	0.010	0	0
Formation of the ureteric bud	R-HSA-9830674	9.780626e-01	0.010	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.781771e-01	0.010	0	0
TCR signaling	R-HSA-202403	9.790068e-01	0.009	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	9.793517e-01	0.009	0	0
Cleavage of the damaged purine	R-HSA-110331	9.793517e-01	0.009	0	0
Degradation of AXIN	R-HSA-4641257	9.793517e-01	0.009	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	9.793517e-01	0.009	0	0
SLC-mediated transport of organic cations	R-HSA-549127	9.793517e-01	0.009	0	0
NCAM1 interactions	R-HSA-419037	9.793517e-01	0.009	0	0
Metabolism of folate and pterines	R-HSA-196757	9.793517e-01	0.009	0	0
Gap junction trafficking and regulation	R-HSA-157858	9.799046e-01	0.009	0	0
Degradation of CDH1	R-HSA-9766229	9.799046e-01	0.009	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.799046e-01	0.009	0	0
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.807721e-01	0.008	0	0
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	9.807721e-01	0.008	0	0
Synthesis of dolichyl-phosphate	R-HSA-446199	9.807721e-01	0.008	0	0
TNFs bind their physiological receptors	R-HSA-5669034	9.807721e-01	0.008	0	0
Plasma lipoprotein assembly	R-HSA-8963898	9.807721e-01	0.008	0	0
SARS-CoV Infections	R-HSA-9679506	9.815316e-01	0.008	0	0
tRNA processing in the mitochondrion	R-HSA-6785470	9.815524e-01	0.008	0	0
Depurination	R-HSA-73927	9.815524e-01	0.008	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	9.815524e-01	0.008	0	0
Azathioprine ADME	R-HSA-9748787	9.818466e-01	0.008	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.824348e-01	0.008	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.828752e-01	0.008	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	9.831471e-01	0.007	0	0
Defects in cobalamin (B12) metabolism	R-HSA-3296469	9.831471e-01	0.007	0	0
Fertilization	R-HSA-1187000	9.831471e-01	0.007	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.835246e-01	0.007	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.835246e-01	0.007	0	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.835246e-01	0.007	0	0
Pentose phosphate pathway	R-HSA-71336	9.835246e-01	0.007	0	0
Opioid Signalling	R-HSA-111885	9.836078e-01	0.007	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	9.836083e-01	0.007	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	9.839599e-01	0.007	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.841106e-01	0.007	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	9.843400e-01	0.007	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	9.852056e-01	0.006	0	0
Attachment of bacteria to epithelial cells	R-HSA-9638630	9.852289e-01	0.006	0	0
TRP channels	R-HSA-3295583	9.852289e-01	0.006	0	0
Urea cycle	R-HSA-70635	9.852289e-01	0.006	0	0
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.852289e-01	0.006	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	9.852913e-01	0.006	0	0
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.852913e-01	0.006	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	9.852913e-01	0.006	0	0
rRNA processing in the mitochondrion	R-HSA-8868766	9.852913e-01	0.006	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.853964e-01	0.006	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.860303e-01	0.006	0	0
Leishmania infection	R-HSA-9658195	9.863859e-01	0.006	0	0
Parasitic Infection Pathways	R-HSA-9824443	9.863859e-01	0.006	0	0
Potassium Channels	R-HSA-1296071	9.866758e-01	0.006	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	9.868730e-01	0.006	0	0
Maturation of spike protein	R-HSA-9694548	9.868730e-01	0.006	0	0
Packaging Of Telomere Ends	R-HSA-171306	9.870536e-01	0.006	0	0
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.870536e-01	0.006	0	0
Cobalamin (Cbl) metabolism	R-HSA-9759218	9.870536e-01	0.006	0	0
Triglyceride biosynthesis	R-HSA-75109	9.870536e-01	0.006	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	9.870536e-01	0.006	0	0
ER Quality Control Compartment (ERQC)	R-HSA-901032	9.870536e-01	0.006	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.874853e-01	0.005	0	0
Interleukin-1 family signaling	R-HSA-446652	9.877782e-01	0.005	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	9.878476e-01	0.005	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	9.879638e-01	0.005	0	0
Cholesterol biosynthesis	R-HSA-191273	9.879789e-01	0.005	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	9.882885e-01	0.005	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	9.882885e-01	0.005	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	9.882885e-01	0.005	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.882885e-01	0.005	0	0
Telomere Extension By Telomerase	R-HSA-171319	9.886530e-01	0.005	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	9.886530e-01	0.005	0	0
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.886530e-01	0.005	0	0
Pyroptosis	R-HSA-5620971	9.886530e-01	0.005	0	0
Regulation of insulin secretion	R-HSA-422356	9.886824e-01	0.005	0	0
Selenoamino acid metabolism	R-HSA-2408522	9.893466e-01	0.005	0	0
Depyrimidination	R-HSA-73928	9.895547e-01	0.005	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	9.895547e-01	0.005	0	0
Downstream TCR signaling	R-HSA-202424	9.896256e-01	0.005	0	0
Regulated Necrosis	R-HSA-5218859	9.897951e-01	0.004	0	0
Neddylation	R-HSA-8951664	9.898411e-01	0.004	0	0
DNA methylation	R-HSA-5334118	9.900549e-01	0.004	0	0
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.900549e-01	0.004	0	0
DARPP-32 events	R-HSA-180024	9.900549e-01	0.004	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.902237e-01	0.004	0	0
ABC-family proteins mediated transport	R-HSA-382556	9.904026e-01	0.004	0	0
Defective pyroptosis	R-HSA-9710421	9.906869e-01	0.004	0	0
Interleukin-1 signaling	R-HSA-9020702	9.911674e-01	0.004	0	0
Regulation of CDH1 Function	R-HSA-9764561	9.911943e-01	0.004	0	0
Neurotransmitter clearance	R-HSA-112311	9.912837e-01	0.004	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	9.915978e-01	0.004	0	0
Gap junction trafficking	R-HSA-190828	9.916989e-01	0.004	0	0
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.916989e-01	0.004	0	0
Proteasome assembly	R-HSA-9907900	9.916989e-01	0.004	0	0
Surfactant metabolism	R-HSA-5683826	9.916989e-01	0.004	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.920715e-01	0.003	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	9.923607e-01	0.003	0	0
Molecules associated with elastic fibres	R-HSA-2129379	9.923607e-01	0.003	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.923607e-01	0.003	0	0
Aspartate and asparagine metabolism	R-HSA-8963693	9.923607e-01	0.003	0	0
ECM proteoglycans	R-HSA-3000178	9.923805e-01	0.003	0	0
Metabolism of porphyrins	R-HSA-189445	9.923805e-01	0.003	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.923855e-01	0.003	0	0
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.926030e-01	0.003	0	0
Degradation of cysteine and homocysteine	R-HSA-1614558	9.926030e-01	0.003	0	0
Triglyceride metabolism	R-HSA-8979227	9.928639e-01	0.003	0	0
Mitochondrial protein degradation	R-HSA-9837999	9.932963e-01	0.003	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	9.934106e-01	0.003	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.934106e-01	0.003	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.934106e-01	0.003	0	0
tRNA Aminoacylation	R-HSA-379724	9.935795e-01	0.003	0	0
GABA receptor activation	R-HSA-977443	9.935795e-01	0.003	0	0
Synthesis of PC	R-HSA-1483191	9.941315e-01	0.003	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	9.941320e-01	0.003	0	0
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.941320e-01	0.003	0	0
Aquaporin-mediated transport	R-HSA-445717	9.942253e-01	0.003	0	0
Nucleotide salvage	R-HSA-8956321	9.942253e-01	0.003	0	0
Endogenous sterols	R-HSA-211976	9.942253e-01	0.003	0	0
Interferon alpha/beta signaling	R-HSA-909733	9.946184e-01	0.002	0	0
Intraflagellar transport	R-HSA-5620924	9.947750e-01	0.002	0	0
Mitochondrial protein import	R-HSA-1268020	9.948078e-01	0.002	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	9.948078e-01	0.002	0	0
CS/DS degradation	R-HSA-2024101	9.948572e-01	0.002	0	0
Miscellaneous transport and binding events	R-HSA-5223345	9.948572e-01	0.002	0	0
Heme degradation	R-HSA-189483	9.948572e-01	0.002	0	0
Citric acid cycle (TCA cycle)	R-HSA-71403	9.948665e-01	0.002	0	0
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.953491e-01	0.002	0	0
Gap junction assembly	R-HSA-190861	9.954928e-01	0.002	0	0
RA biosynthesis pathway	R-HSA-5365859	9.954928e-01	0.002	0	0
Mitophagy	R-HSA-5205647	9.954928e-01	0.002	0	0
Calnexin/calreticulin cycle	R-HSA-901042	9.954928e-01	0.002	0	0
Hyaluronan metabolism	R-HSA-2142845	9.954928e-01	0.002	0	0
ER-Phagosome pathway	R-HSA-1236974	9.960472e-01	0.002	0	0
Metabolism of ingested SeMet, Sec, MeSec into H2Se	R-HSA-2408508	9.960499e-01	0.002	0	0
PERK regulates gene expression	R-HSA-381042	9.960499e-01	0.002	0	0
Transferrin endocytosis and recycling	R-HSA-917977	9.960499e-01	0.002	0	0
Transmission across Chemical Synapses	R-HSA-112315	9.960561e-01	0.002	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.960970e-01	0.002	0	0
Disorders of transmembrane transporters	R-HSA-5619115	9.961913e-01	0.002	0	0
Branched-chain amino acid catabolism	R-HSA-70895	9.963177e-01	0.002	0	0
Cytosolic sulfonation of small molecules	R-HSA-156584	9.963177e-01	0.002	0	0
Class B/2 (Secretin family receptors)	R-HSA-373080	9.964058e-01	0.002	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	9.965382e-01	0.002	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	9.967246e-01	0.001	0	0
Cardiac conduction	R-HSA-5576891	9.969612e-01	0.001	0	0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.969638e-01	0.001	0	0
G alpha (s) signalling events	R-HSA-418555	9.969905e-01	0.001	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	9.969905e-01	0.001	0	0
Elastic fibre formation	R-HSA-1566948	9.973411e-01	0.001	0	0
Biofilm formation	R-HSA-9931953	9.973411e-01	0.001	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.974210e-01	0.001	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.975513e-01	0.001	0	0
Chondroitin sulfate/dermatan sulfate metabolism	R-HSA-1793185	9.976980e-01	0.001	0	0
Paracetamol ADME	R-HSA-9753281	9.976980e-01	0.001	0	0
SARS-CoV-1 Infection	R-HSA-9678108	9.977591e-01	0.001	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	9.979579e-01	0.001	0	0
Diseases of Immune System	R-HSA-5260271	9.979579e-01	0.001	0	0
Glycogen metabolism	R-HSA-8982491	9.979579e-01	0.001	0	0
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.979579e-01	0.001	0	0
Synthesis of PA	R-HSA-1483166	9.981823e-01	0.001	0	0
Peptide hormone metabolism	R-HSA-2980736	9.982979e-01	0.001	0	0
Intra-Golgi traffic	R-HSA-6811438	9.984317e-01	0.001	0	0
Scavenging by Class A Receptors	R-HSA-3000480	9.984317e-01	0.001	0	0
Stimuli-sensing channels	R-HSA-2672351	9.984403e-01	0.001	0	0
RAB geranylgeranylation	R-HSA-8873719	9.987264e-01	0.001	0	0
Signaling by Retinoic Acid	R-HSA-5362517	9.987264e-01	0.001	0	0
Metabolism of polyamines	R-HSA-351202	9.987264e-01	0.001	0	0
Protein ubiquitination	R-HSA-8852135	9.987324e-01	0.001	0	0
Iron uptake and transport	R-HSA-917937	9.987324e-01	0.001	0	0
Pyrimidine catabolism	R-HSA-73621	9.987956e-01	0.001	0	0
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.989445e-01	0.000	0	0
Protein localization	R-HSA-9609507	9.989465e-01	0.000	0	0
ABC transporter disorders	R-HSA-5619084	9.990903e-01	0.000	0	0
Integrin cell surface interactions	R-HSA-216083	9.990903e-01	0.000	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.992675e-01	0.000	0	0
Neuronal System	R-HSA-112316	9.993455e-01	0.000	0	0
Interferon gamma signaling	R-HSA-877300	9.993629e-01	0.000	0	0
Platelet degranulation	R-HSA-114608	9.993771e-01	0.000	0	0
Gluconeogenesis	R-HSA-70263	9.993776e-01	0.000	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.993778e-01	0.000	0	0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.995221e-01	0.000	0	0
Antigen processing-Cross presentation	R-HSA-1236975	9.995456e-01	0.000	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.995683e-01	0.000	0	0
Sulfur amino acid metabolism	R-HSA-1614635	9.996678e-01	0.000	0	0
Ion channel transport	R-HSA-983712	9.996826e-01	0.000	0	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.996977e-01	0.000	0	0
Formation of the cornified envelope	R-HSA-6809371	9.997240e-01	0.000	0	0
Adaptive Immune System	R-HSA-1280218	9.997243e-01	0.000	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.997627e-01	0.000	0	0
Metabolism of amine-derived hormones	R-HSA-209776	9.997836e-01	0.000	0	0
Metabolism of steroids	R-HSA-8957322	9.998228e-01	0.000	0	0
Translation of Structural Proteins	R-HSA-9694635	9.998350e-01	0.000	0	0
Phospholipid metabolism	R-HSA-1483257	9.998476e-01	0.000	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	9.998544e-01	0.000	0	0
Glutathione conjugation	R-HSA-156590	9.998725e-01	0.000	0	0
Translation	R-HSA-72766	9.998754e-01	0.000	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999032e-01	0.000	0	0
Mitochondrial translation termination	R-HSA-5419276	9.999046e-01	0.000	0	0
Hemostasis	R-HSA-109582	9.999061e-01	0.000	0	0
Complex I biogenesis	R-HSA-6799198	9.999142e-01	0.000	0	0
Mitochondrial translation elongation	R-HSA-5389840	9.999154e-01	0.000	0	0
CD22 mediated BCR regulation	R-HSA-5690714	9.999248e-01	0.000	0	0
Post-translational protein phosphorylation	R-HSA-8957275	9.999328e-01	0.000	0	0
Mitochondrial translation initiation	R-HSA-5368286	9.999328e-01	0.000	0	0
G alpha (q) signalling events	R-HSA-416476	9.999383e-01	0.000	1	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.999401e-01	0.000	0	0
Viral Infection Pathways	R-HSA-9824446	9.999415e-01	0.000	0	0
Extracellular matrix organization	R-HSA-1474244	9.999483e-01	0.000	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	9.999494e-01	0.000	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.999506e-01	0.000	0	0
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999623e-01	0.000	0	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.999702e-01	0.000	0	0
Retinoid metabolism and transport	R-HSA-975634	9.999702e-01	0.000	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	9.999756e-01	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999761e-01	0.000	0	0
Diseases of carbohydrate metabolism	R-HSA-5663084	9.999771e-01	0.000	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.999794e-01	0.000	0	0
Bile acid and bile salt metabolism	R-HSA-194068	9.999852e-01	0.000	0	0
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.999858e-01	0.000	0	0
Mitochondrial translation	R-HSA-5368287	9.999885e-01	0.000	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.999921e-01	0.000	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999935e-01	0.000	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.999955e-01	0.000	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999955e-01	0.000	0	0
Classical antibody-mediated complement activation	R-HSA-173623	9.999972e-01	0.000	0	0
Neutrophil degranulation	R-HSA-6798695	9.999976e-01	0.000	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.999984e-01	0.000	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	9.999987e-01	0.000	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999987e-01	0.000	0	0
FCGR activation	R-HSA-2029481	9.999988e-01	0.000	0	0
Initial triggering of complement	R-HSA-166663	9.999991e-01	0.000	0	0
Scavenging of heme from plasma	R-HSA-2168880	9.999992e-01	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	9.999996e-01	0.000	0	0
Asparagine N-linked glycosylation	R-HSA-446203	9.999998e-01	0.000	0	0
Regulation of Complement cascade	R-HSA-977606	9.999998e-01	0.000	0	0
Creation of C4 and C2 activators	R-HSA-166786	9.999998e-01	0.000	0	0
Nucleotide catabolism	R-HSA-8956319	9.999999e-01	0.000	0	0
Antimicrobial peptides	R-HSA-6803157	9.999999e-01	0.000	0	0
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999999e-01	0.000	0	0
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000	0	0
Immune System	R-HSA-168256	1.000000e+00	0.000	1	0
Glycerophospholipid biosynthesis	R-HSA-1483206	1.000000e+00	0.000	0	0
Post-translational protein modification	R-HSA-597592	1.000000e+00	0.000	0	0
Keratinization	R-HSA-6805567	1.000000e+00	0.000	0	0
Respiratory electron transport	R-HSA-611105	1.000000e+00	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000	0	0
Complement cascade	R-HSA-166658	1.000000e+00	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000	0	0
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	1.000000e+00	0.000	0	0
GPCR downstream signalling	R-HSA-388396	1.000000e+00	0.000	1	0
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000	0	0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000	0	0
Infectious disease	R-HSA-5663205	1.000000e+00	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	1.000000e+00	0.000	0	0
Disease	R-HSA-1643685	1.000000e+00	0.000	0	0
Visual phototransduction	R-HSA-2187338	1.000000e+00	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000	0	0
Drug ADME	R-HSA-9748784	1.000000e+00	0.000	0	0
Innate Immune System	R-HSA-168249	1.000000e+00	0.000	1	0
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000	0	0
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000	1	0
Peptide ligand-binding receptors	R-HSA-375276	1.000000e+00	0.000	0	0
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000	0	0
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000	0	0
G alpha (i) signalling events	R-HSA-418594	1.000000e+00	0.000	0	0
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0
Transport of small molecules	R-HSA-382551	1.000000e+00	-0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	-0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	-0.000	0	0
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p	ref_path	ref_path_lowest
Cellular response to heat stress	R-HSA-3371556	1.110223e-16	15.955	0	0
Cellular responses to stress	R-HSA-2262752	1.110223e-16	15.955	1	0
Cellular responses to stimuli	R-HSA-8953897	1.110223e-16	15.955	1	0
Cell Cycle	R-HSA-1640170	2.220446e-15	14.654	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	1.554312e-14	13.808	0	0
Cell Cycle, Mitotic	R-HSA-69278	1.965095e-14	13.707	0	0
M Phase	R-HSA-68886	7.904788e-14	13.102	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	4.609646e-13	12.336	0	0
HSF1-dependent transactivation	R-HSA-3371571	5.575651e-12	11.254	0	0
Attenuation phase	R-HSA-3371568	3.119971e-11	10.506	0	0
Recycling pathway of L1	R-HSA-437239	1.542814e-10	9.812	0	0
Axon guidance	R-HSA-422475	1.780943e-10	9.749	1	0
Nervous system development	R-HSA-9675108	1.857334e-10	9.731	1	0
Cellular Senescence	R-HSA-2559583	7.546537e-10	9.122	1	0
HSF1 activation	R-HSA-3371511	9.369094e-10	9.028	0	0
Aggrephagy	R-HSA-9646399	9.050868e-10	9.043	0	0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	1.461219e-09	8.835	0	0
Mitotic Anaphase	R-HSA-68882	1.936123e-09	8.713	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	2.242784e-09	8.649	0	0
Transport of connexons to the plasma membrane	R-HSA-190872	2.715733e-09	8.566	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	4.127748e-09	8.384	0	0
Mitotic Prometaphase	R-HSA-68877	5.976613e-09	8.224	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	7.018179e-09	8.154	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	7.260371e-09	8.139	0	0
PKR-mediated signaling	R-HSA-9833482	1.143016e-08	7.942	0	0
Separation of Sister Chromatids	R-HSA-2467813	1.867451e-08	7.729	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	4.045554e-08	7.393	0	0
Apoptotic execution phase	R-HSA-75153	5.083546e-08	7.294	0	0
Mitotic Prophase	R-HSA-68875	5.336121e-08	7.273	0	0
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	1.006001e-07	6.997	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	1.001559e-07	6.999	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	9.397283e-08	7.027	0	0
Gap junction trafficking	R-HSA-190828	1.167769e-07	6.933	0	0
Gap junction trafficking and regulation	R-HSA-157858	1.265934e-07	6.898	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	1.368527e-07	6.864	0	0
Membrane Trafficking	R-HSA-199991	1.503022e-07	6.823	0	0
Cell Cycle Checkpoints	R-HSA-69620	1.943626e-07	6.711	0	0
L1CAM interactions	R-HSA-373760	2.159191e-07	6.666	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	3.205405e-07	6.494	0	0
Post-chaperonin tubulin folding pathway	R-HSA-389977	3.507054e-07	6.455	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	3.488604e-07	6.457	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	4.254476e-07	6.371	0	0
Cell-Cell communication	R-HSA-1500931	4.942416e-07	6.306	0	0
COPI-mediated anterograde transport	R-HSA-6807878	6.864694e-07	6.163	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	7.580752e-07	6.120	1	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	9.168648e-07	6.038	0	0
Selective autophagy	R-HSA-9663891	9.168648e-07	6.038	0	0
Signal Transduction	R-HSA-162582	1.044365e-06	5.981	1	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	1.407461e-06	5.852	0	0
Cell junction organization	R-HSA-446728	1.670228e-06	5.777	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.891702e-06	5.723	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	1.951398e-06	5.710	0	0
Interferon Signaling	R-HSA-913531	2.242515e-06	5.649	0	0
Metabolism of RNA	R-HSA-8953854	2.196196e-06	5.658	0	0
Macroautophagy	R-HSA-1632852	2.516367e-06	5.599	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	2.708516e-06	5.567	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	2.950353e-06	5.530	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	3.505934e-06	5.455	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	3.505934e-06	5.455	0	0
Apoptosis	R-HSA-109581	3.468929e-06	5.460	0	0
Autophagy	R-HSA-9612973	3.758433e-06	5.425	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	3.826465e-06	5.417	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	4.039657e-06	5.394	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	5.585969e-06	5.253	0	0
Gap junction assembly	R-HSA-190861	5.476303e-06	5.262	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	5.915849e-06	5.228	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	6.697798e-06	5.174	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	6.697798e-06	5.174	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	6.696790e-06	5.174	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	8.265407e-06	5.083	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	8.808576e-06	5.055	0	0
HCMV Early Events	R-HSA-9609690	8.833656e-06	5.054	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	1.192037e-05	4.924	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.300960e-05	4.886	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.272796e-05	4.895	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	1.543472e-05	4.812	0	0
ISG15 antiviral mechanism	R-HSA-1169408	1.558474e-05	4.807	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.592236e-05	4.798	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	1.592236e-05	4.798	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	1.668096e-05	4.778	0	0
Mitotic G2-G2/M phases	R-HSA-453274	1.698985e-05	4.770	0	0
Interleukin-12 signaling	R-HSA-9020591	1.872276e-05	4.728	0	0
Chaperonin-mediated protein folding	R-HSA-390466	1.888668e-05	4.724	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	1.890926e-05	4.723	0	0
Translation initiation complex formation	R-HSA-72649	2.207802e-05	4.656	0	0
Adherens junctions interactions	R-HSA-418990	2.248980e-05	4.648	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	2.408910e-05	4.618	0	0
Programmed Cell Death	R-HSA-5357801	2.563823e-05	4.591	0	0
Chromatin organization	R-HSA-4839726	2.721650e-05	4.565	0	0
Cap-dependent Translation Initiation	R-HSA-72737	2.791868e-05	4.554	0	0
Eukaryotic Translation Initiation	R-HSA-72613	2.791868e-05	4.554	0	0
Developmental Biology	R-HSA-1266738	3.174292e-05	4.498	1	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	3.719019e-05	4.430	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	3.582359e-05	4.446	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	4.209838e-05	4.376	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	5.272359e-05	4.278	0	0
Protein folding	R-HSA-391251	4.945165e-05	4.306	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	5.201723e-05	4.284	0	0
Interleukin-12 family signaling	R-HSA-447115	5.133193e-05	4.290	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	6.107366e-05	4.214	0	0
G2/M Transition	R-HSA-69275	6.111793e-05	4.214	0	0
Cell-cell junction organization	R-HSA-421270	6.319186e-05	4.199	0	0
Nuclear import of Rev protein	R-HSA-180746	8.446720e-05	4.073	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	8.665465e-05	4.062	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	1.041281e-04	3.982	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.131647e-04	3.946	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.131647e-04	3.946	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.082078e-04	3.966	0	0
Post NMDA receptor activation events	R-HSA-438064	1.341366e-04	3.872	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	1.408153e-04	3.851	1	1
Cell-extracellular matrix interactions	R-HSA-446353	1.475091e-04	3.831	0	0
Vesicle-mediated transport	R-HSA-5653656	1.497205e-04	3.825	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	1.613877e-04	3.792	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.770003e-04	3.752	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	1.789048e-04	3.747	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	1.770003e-04	3.752	0	0
snRNP Assembly	R-HSA-191859	1.808926e-04	3.743	0	0
Metabolism of non-coding RNA	R-HSA-194441	1.808926e-04	3.743	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	1.876999e-04	3.727	0	0
Chromatin modifying enzymes	R-HSA-3247509	1.909685e-04	3.719	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	2.157003e-04	3.666	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	2.134152e-04	3.671	0	0
Signaling by ALK in cancer	R-HSA-9700206	2.134152e-04	3.671	0	0
HCMV Infection	R-HSA-9609646	2.053744e-04	3.687	0	0
Estrogen-dependent gene expression	R-HSA-9018519	2.075695e-04	3.683	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	2.157003e-04	3.666	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	2.315479e-04	3.635	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	2.386225e-04	3.622	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	2.432244e-04	3.614	0	0
DNA Double Strand Break Response	R-HSA-5693606	2.514426e-04	3.600	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	2.702910e-04	3.568	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	3.340148e-04	3.476	0	0
Nucleosome assembly	R-HSA-774815	3.543654e-04	3.451	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	3.543654e-04	3.451	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	3.544709e-04	3.450	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	4.101773e-04	3.387	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	4.468973e-04	3.350	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	4.504388e-04	3.346	0	0
Gene Silencing by RNA	R-HSA-211000	4.889702e-04	3.311	0	0
Influenza Infection	R-HSA-168255	5.035843e-04	3.298	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	5.077387e-04	3.294	0	0
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	5.162738e-04	3.287	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	5.179281e-04	3.286	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	5.290694e-04	3.276	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	5.398251e-04	3.268	0	0
Amplification of signal from the kinetochores	R-HSA-141424	6.240106e-04	3.205	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	6.240106e-04	3.205	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	5.740195e-04	3.241	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	5.771876e-04	3.239	0	0
Kinesins	R-HSA-983189	5.981422e-04	3.223	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	6.540355e-04	3.184	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	6.940239e-04	3.159	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	7.073586e-04	3.150	0	0
G2/M DNA damage checkpoint	R-HSA-69473	7.260197e-04	3.139	0	0
Eukaryotic Translation Elongation	R-HSA-156842	7.387438e-04	3.132	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	7.592738e-04	3.120	0	0
Formation of annular gap junctions	R-HSA-196025	9.046351e-04	3.044	0	0
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	8.571996e-04	3.067	0	0
DNA methylation	R-HSA-5334118	9.117595e-04	3.040	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	9.117595e-04	3.040	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	9.046351e-04	3.044	0	0
HATs acetylate histones	R-HSA-3214847	8.533213e-04	3.069	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	8.804190e-04	3.055	0	0
MITF-M-dependent gene expression	R-HSA-9856651	9.435926e-04	3.025	0	0
Semaphorin interactions	R-HSA-373755	9.509889e-04	3.022	0	0
Deadenylation of mRNA	R-HSA-429947	9.947513e-04	3.002	0	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	9.947513e-04	3.002	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	9.990702e-04	3.000	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.037755e-03	2.984	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	1.042617e-03	2.982	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	1.042617e-03	2.982	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	1.238120e-03	2.907	0	0
mRNA Splicing	R-HSA-72172	1.240628e-03	2.906	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	1.249788e-03	2.903	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	1.254643e-03	2.901	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	1.273882e-03	2.895	0	0
G2/M Checkpoints	R-HSA-69481	1.278602e-03	2.893	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	1.333305e-03	2.875	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	1.358650e-03	2.867	0	0
Gap junction degradation	R-HSA-190873	1.403958e-03	2.853	0	0
Smooth Muscle Contraction	R-HSA-445355	1.426708e-03	2.846	0	0
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	1.740235e-03	2.759	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	1.732693e-03	2.761	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.740787e-03	2.759	0	0
Assembly of the pre-replicative complex	R-HSA-68867	1.879146e-03	2.726	0	0
Signaling by ROBO receptors	R-HSA-376176	1.913857e-03	2.718	0	0
HDACs deacetylate histones	R-HSA-3214815	1.936463e-03	2.713	0	0
Packaging Of Telomere Ends	R-HSA-171306	1.988425e-03	2.701	0	0
Glycolysis	R-HSA-70171	2.092828e-03	2.679	0	0
Diseases of programmed cell death	R-HSA-9645723	2.094256e-03	2.679	0	0
Signaling by VEGF	R-HSA-194138	2.127381e-03	2.672	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	2.217143e-03	2.654	0	0
mTORC1-mediated signalling	R-HSA-166208	2.223156e-03	2.653	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	2.385764e-03	2.622	0	0
Ephrin signaling	R-HSA-3928664	2.385764e-03	2.622	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	2.387699e-03	2.622	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	2.397428e-03	2.620	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	2.397428e-03	2.620	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	2.409497e-03	2.618	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	2.589510e-03	2.587	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	2.616506e-03	2.582	0	0
DNA Replication Pre-Initiation	R-HSA-69002	2.805388e-03	2.552	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	2.924699e-03	2.534	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	3.035597e-03	2.518	0	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	3.209421e-03	2.494	0	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	3.209421e-03	2.494	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	3.414517e-03	2.467	0	0
AURKA Activation by TPX2	R-HSA-8854518	3.556020e-03	2.449	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	3.223683e-03	2.492	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	3.580121e-03	2.446	0	0
EPH-Ephrin signaling	R-HSA-2682334	3.642610e-03	2.439	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	3.661359e-03	2.436	0	0
Meiotic synapsis	R-HSA-1221632	3.699957e-03	2.432	0	0
Nephrin family interactions	R-HSA-373753	3.923731e-03	2.406	0	0
Signaling by Interleukins	R-HSA-449147	3.958249e-03	2.402	1	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	4.223680e-03	2.374	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	4.296842e-03	2.367	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	4.296842e-03	2.367	0	0
PRC2 methylates histones and DNA	R-HSA-212300	4.364734e-03	2.360	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	4.383594e-03	2.358	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	4.417103e-03	2.355	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	4.444317e-03	2.352	0	0
PTEN Regulation	R-HSA-6807070	4.497388e-03	2.347	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	4.904738e-03	2.309	0	0
Depyrimidination	R-HSA-73928	4.904738e-03	2.309	0	0
Signaling by NOTCH	R-HSA-157118	4.979978e-03	2.303	0	0
tRNA processing in the nucleus	R-HSA-6784531	5.046561e-03	2.297	0	0
Adrenoceptors	R-HSA-390696	5.152700e-03	2.288	0	0
Chromosome Maintenance	R-HSA-73886	5.189199e-03	2.285	0	0
G0 and Early G1	R-HSA-1538133	5.290587e-03	2.276	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	5.290587e-03	2.276	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	5.558146e-03	2.255	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	6.680618e-03	2.175	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	6.215024e-03	2.207	0	0
RNA Polymerase I Promoter Opening	R-HSA-73728	6.358200e-03	2.197	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	6.834450e-03	2.165	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	6.358200e-03	2.197	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	6.358200e-03	2.197	0	0
MHC class II antigen presentation	R-HSA-2132295	6.159304e-03	2.210	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	6.863925e-03	2.163	0	0
Signaling by Hippo	R-HSA-2028269	6.968137e-03	2.157	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	7.370501e-03	2.133	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	7.370501e-03	2.133	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	7.661221e-03	2.116	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	7.661221e-03	2.116	0	0
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	7.661221e-03	2.116	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	7.661221e-03	2.116	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	7.661221e-03	2.116	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	7.661221e-03	2.116	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	7.661221e-03	2.116	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	7.661221e-03	2.116	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	7.661221e-03	2.116	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	7.661221e-03	2.116	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	7.661221e-03	2.116	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	7.661221e-03	2.116	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	7.927909e-03	2.101	0	0
Epigenetic regulation of gene expression	R-HSA-212165	7.957550e-03	2.099	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	8.098676e-03	2.092	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	8.459347e-03	2.073	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	8.696558e-03	2.061	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	8.711383e-03	2.060	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	8.753751e-03	2.058	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.182951e-03	2.037	0	0
Peptide chain elongation	R-HSA-156902	9.480805e-03	2.023	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	9.487645e-03	2.023	0	0
S Phase	R-HSA-69242	9.676369e-03	2.014	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	1.000510e-02	2.000	0	0
Centrosome maturation	R-HSA-380287	1.001911e-02	1.999	0	0
Protein ubiquitination	R-HSA-8852135	1.001911e-02	1.999	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.013144e-02	1.994	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.020493e-02	1.991	0	0
Neutrophil degranulation	R-HSA-6798695	1.049038e-02	1.979	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.247461e-02	1.904	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	1.246214e-02	1.904	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	1.189090e-02	1.925	0	0
Oncogenic MAPK signaling	R-HSA-6802957	1.307517e-02	1.884	0	0
MTOR signalling	R-HSA-165159	1.250690e-02	1.903	0	0
Cilium Assembly	R-HSA-5617833	1.176417e-02	1.929	0	0
Intraflagellar transport	R-HSA-5620924	1.132504e-02	1.946	0	0
Deubiquitination	R-HSA-5688426	1.176323e-02	1.929	0	0
Base Excision Repair	R-HSA-73884	1.145189e-02	1.941	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.189090e-02	1.925	0	0
Neurodegenerative Diseases	R-HSA-8863678	1.106884e-02	1.956	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.106884e-02	1.956	0	0
Glucose metabolism	R-HSA-70326	1.312447e-02	1.882	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	1.369156e-02	1.864	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.369156e-02	1.864	0	0
Cleavage of the damaged purine	R-HSA-110331	1.369156e-02	1.864	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	1.397470e-02	1.855	0	0
Defective pyroptosis	R-HSA-9710421	1.426608e-02	1.846	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	1.440370e-02	1.842	0	0
Regulation of CDH1 Function	R-HSA-9764561	1.449331e-02	1.839	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	1.545392e-02	1.811	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	1.564865e-02	1.806	0	0
Depurination	R-HSA-73927	1.573726e-02	1.803	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	1.641015e-02	1.785	0	0
Hedgehog 'off' state	R-HSA-5610787	1.686881e-02	1.773	0	0
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	1.712439e-02	1.766	0	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	1.717911e-02	1.765	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	1.750914e-02	1.757	1	0
HIV Life Cycle	R-HSA-162587	1.777758e-02	1.750	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	1.805354e-02	1.743	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	1.822469e-02	1.739	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	1.822469e-02	1.739	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	1.822469e-02	1.739	0	0
Signaling by WNT	R-HSA-195721	1.850252e-02	1.733	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	1.916009e-02	1.718	0	0
Regulation of endogenous retroelements	R-HSA-9842860	1.981619e-02	1.703	0	0
Striated Muscle Contraction	R-HSA-390522	1.982761e-02	1.703	0	0
Signaling by ERBB2	R-HSA-1227986	2.006368e-02	1.698	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	2.060171e-02	1.686	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	2.062107e-02	1.686	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	2.066770e-02	1.685	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	2.066770e-02	1.685	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	2.066770e-02	1.685	0	0
Signaling by RAS mutants	R-HSA-6802949	2.066770e-02	1.685	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	2.090711e-02	1.680	0	0
Host Interactions of HIV factors	R-HSA-162909	2.199508e-02	1.658	0	0
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	2.238539e-02	1.650	0	0
Repression of WNT target genes	R-HSA-4641265	2.257584e-02	1.646	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	2.260535e-02	1.646	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	2.275902e-02	1.643	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	2.284072e-02	1.641	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	2.296076e-02	1.639	0	0
DNA Replication	R-HSA-69306	2.303813e-02	1.638	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	2.323551e-02	1.634	0	0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	2.473220e-02	1.607	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	2.826153e-02	1.549	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	2.826153e-02	1.549	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	2.826153e-02	1.549	0	0
MAP2K and MAPK activation	R-HSA-5674135	2.622904e-02	1.581	0	0
Signaling by RAF1 mutants	R-HSA-9656223	2.622904e-02	1.581	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	2.948873e-02	1.530	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	2.594857e-02	1.586	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	2.700000e-02	1.569	0	0
Telomere Maintenance	R-HSA-157579	2.463411e-02	1.608	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	2.883641e-02	1.540	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	2.710194e-02	1.567	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	2.702507e-02	1.568	0	0
RNA Polymerase I Transcription	R-HSA-73864	2.700000e-02	1.569	0	0
Activation of BH3-only proteins	R-HSA-114452	2.883641e-02	1.540	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	2.826153e-02	1.549	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	2.683219e-02	1.571	0	0
Intracellular signaling by second messengers	R-HSA-9006925	2.765407e-02	1.558	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	2.899363e-02	1.538	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	2.473220e-02	1.607	0	0
Homology Directed Repair	R-HSA-5693538	2.524355e-02	1.598	0	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	2.704237e-02	1.568	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	2.841582e-02	1.546	0	0
ALK mutants bind TKIs	R-HSA-9700645	3.247743e-02	1.488	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	3.247743e-02	1.488	0	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	3.309475e-02	1.480	0	0
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	3.309475e-02	1.480	0	0
G2 Phase	R-HSA-68911	3.309475e-02	1.480	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	3.473697e-02	1.459	0	0
Regulation of TP53 Activity	R-HSA-5633007	3.477656e-02	1.459	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	3.477994e-02	1.459	0	0
Manipulation of host energy metabolism	R-HSA-9636667	3.612612e-02	1.442	0	0
Breakdown of the nuclear lamina	R-HSA-352238	3.612612e-02	1.442	0	0
Sema4D in semaphorin signaling	R-HSA-400685	3.662513e-02	1.436	0	0
HIV Infection	R-HSA-162906	3.688309e-02	1.433	0	0
ESR-mediated signaling	R-HSA-8939211	3.928545e-02	1.406	0	0
mRNA 3'-end processing	R-HSA-72187	3.942286e-02	1.404	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	3.942286e-02	1.404	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	3.992205e-02	1.399	0	0
Muscle contraction	R-HSA-397014	4.088215e-02	1.388	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	4.088215e-02	1.388	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	4.105992e-02	1.387	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	4.108644e-02	1.386	0	0
Signaling by Leptin	R-HSA-2586552	4.148872e-02	1.382	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	4.213557e-02	1.375	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	4.213557e-02	1.375	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	4.215599e-02	1.375	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	4.215599e-02	1.375	0	0
Protein methylation	R-HSA-8876725	4.215599e-02	1.375	0	0
Myogenesis	R-HSA-525793	4.216086e-02	1.375	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	4.260263e-02	1.371	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	4.342484e-02	1.362	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	4.416709e-02	1.355	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	4.418316e-02	1.355	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	4.515911e-02	1.345	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	4.601128e-02	1.337	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	4.632424e-02	1.334	0	0
HCMV Late Events	R-HSA-9610379	4.669217e-02	1.331	0	0
Meiosis	R-HSA-1500620	4.739776e-02	1.324	0	0
Platelet degranulation	R-HSA-114608	4.800261e-02	1.319	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	4.811285e-02	1.318	0	0
PIP3 activates AKT signaling	R-HSA-1257604	4.938385e-02	1.306	0	0
Regulation of TP53 Expression	R-HSA-6804754	6.025113e-02	1.220	0	0
Signalling to ERK5	R-HSA-198765	6.025113e-02	1.220	1	1
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	6.025113e-02	1.220	0	0
Activation of RAC1	R-HSA-428540	6.331915e-02	1.198	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	5.040547e-02	1.298	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	5.953519e-02	1.225	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	5.953519e-02	1.225	0	0
Late endosomal microautophagy	R-HSA-9615710	6.189554e-02	1.208	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	5.398744e-02	1.268	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	6.234740e-02	1.205	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	5.101129e-02	1.292	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	6.379904e-02	1.195	0	0
Cytochrome c-mediated apoptotic response	R-HSA-111461	6.331915e-02	1.198	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	6.055969e-02	1.218	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	6.055969e-02	1.218	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	6.706084e-02	1.174	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	5.362497e-02	1.271	0	0
Signaling by PTK6	R-HSA-8848021	5.362497e-02	1.271	0	0
Rab regulation of trafficking	R-HSA-9007101	6.679360e-02	1.175	0	0
Switching of origins to a post-replicative state	R-HSA-69052	6.345238e-02	1.198	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	5.953519e-02	1.225	0	0
Oncogene Induced Senescence	R-HSA-2559585	6.030166e-02	1.220	0	0
Eukaryotic Translation Termination	R-HSA-72764	6.651164e-02	1.177	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	6.189554e-02	1.208	1	0
DNA Repair	R-HSA-73894	5.419852e-02	1.266	0	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	6.025113e-02	1.220	0	0
CREB phosphorylation	R-HSA-199920	6.104205e-02	1.214	0	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	6.331915e-02	1.198	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	6.338130e-02	1.198	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	5.600836e-02	1.252	1	0
Signaling by Hedgehog	R-HSA-5358351	6.216518e-02	1.206	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	5.953519e-02	1.225	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	6.553342e-02	1.184	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	5.707881e-02	1.244	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	6.770213e-02	1.169	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	6.898878e-02	1.161	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	6.898878e-02	1.161	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	6.898878e-02	1.161	0	0
Interleukin-37 signaling	R-HSA-9008059	6.954103e-02	1.158	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	6.954329e-02	1.158	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	6.954329e-02	1.158	0	0
Meiotic recombination	R-HSA-912446	7.230711e-02	1.141	0	0
Viral Infection Pathways	R-HSA-9824446	7.296830e-02	1.137	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	7.426832e-02	1.129	0	0
Cellular response to starvation	R-HSA-9711097	7.548124e-02	1.122	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	7.609705e-02	1.119	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	7.609705e-02	1.119	0	0
Scavenging by Class F Receptors	R-HSA-3000484	7.609705e-02	1.119	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	7.658287e-02	1.116	1	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	7.805295e-02	1.108	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	7.805295e-02	1.108	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	7.805295e-02	1.108	0	0
UCH proteinases	R-HSA-5689603	7.875594e-02	1.104	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	8.011136e-02	1.096	1	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	8.011136e-02	1.096	1	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	8.011136e-02	1.096	1	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	8.014961e-02	1.096	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	8.014961e-02	1.096	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	8.041966e-02	1.095	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	8.041966e-02	1.095	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	8.131101e-02	1.090	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	8.559850e-02	1.068	0	0
MAP kinase activation	R-HSA-450294	8.561404e-02	1.067	1	0
Beta-catenin independent WNT signaling	R-HSA-3858494	8.693010e-02	1.061	0	0
Immune System	R-HSA-168256	8.775705e-02	1.057	1	0
Synthesis of DNA	R-HSA-69239	8.786529e-02	1.056	0	0
MET activates STAT3	R-HSA-8875791	8.836843e-02	1.054	0	0
MET interacts with TNS proteins	R-HSA-8875513	8.836843e-02	1.054	0	0
Adrenaline signalling through Alpha-2 adrenergic receptor	R-HSA-392023	8.836843e-02	1.054	0	0
MET activates PTPN11	R-HSA-8865999	8.836843e-02	1.054	0	0
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	8.836843e-02	1.054	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	9.003140e-02	1.046	0	0
TGFBR3 expression	R-HSA-9839394	9.019012e-02	1.045	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	9.019012e-02	1.045	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.164973e-02	1.038	0	0
Signaling by TGFBR3	R-HSA-9839373	9.183860e-02	1.037	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	9.214651e-02	1.036	1	1
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	9.286851e-02	1.032	1	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.304924e-02	1.031	0	0
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	9.408023e-02	1.027	0	0
Loss of Function of TP53 in Cancer	R-HSA-9723907	9.408023e-02	1.027	0	0
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	9.408023e-02	1.027	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	9.435358e-02	1.025	0	0
Selenocysteine synthesis	R-HSA-2408557	9.540458e-02	1.020	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	9.570024e-02	1.019	0	0
Sensory processing of sound	R-HSA-9659379	9.623587e-02	1.017	0	0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	9.688088e-02	1.014	0	0
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	9.688088e-02	1.014	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	9.688088e-02	1.014	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	9.804917e-02	1.009	1	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	9.977126e-02	1.001	0	0
Gene expression (Transcription)	R-HSA-74160	1.001968e-01	0.999	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	1.008800e-01	0.996	0	0
Ub-specific processing proteases	R-HSA-5689880	1.040950e-01	0.983	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	1.045904e-01	0.981	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	1.046990e-01	0.980	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.046990e-01	0.980	0	0
Formation of definitive endoderm	R-HSA-9823730	1.046990e-01	0.980	0	0
Regulation of KIT signaling	R-HSA-1433559	1.051590e-01	0.978	0	0
Malate-aspartate shuttle	R-HSA-9856872	1.051590e-01	0.978	0	0
Regulation of gap junction activity	R-HSA-191650	1.195143e-01	0.923	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	1.195143e-01	0.923	0	0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	1.195143e-01	0.923	0	0
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	1.528707e-01	0.816	0	0
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	1.528707e-01	0.816	0	0
IRS activation	R-HSA-74713	1.528707e-01	0.816	0	0
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	1.528707e-01	0.816	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	1.528707e-01	0.816	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	1.392486e-01	0.856	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.392486e-01	0.856	0	0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	1.392486e-01	0.856	0	0
Folding of actin by CCT/TriC	R-HSA-390450	1.392486e-01	0.856	0	0
Phosphorylation of the APC/C	R-HSA-176412	1.384637e-01	0.859	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	1.180459e-01	0.928	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	1.321503e-01	0.879	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	1.122041e-01	0.950	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	1.122041e-01	0.950	0	0
FGFR2 alternative splicing	R-HSA-6803529	1.469706e-01	0.833	0	0
Notch-HLH transcription pathway	R-HSA-350054	1.469706e-01	0.833	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	1.157749e-01	0.936	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	1.497725e-01	0.825	0	0
Activation of the pre-replicative complex	R-HSA-68962	1.497725e-01	0.825	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	1.497725e-01	0.825	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	1.378602e-01	0.861	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	1.551610e-01	0.809	0	0
Viral mRNA Translation	R-HSA-192823	1.065524e-01	0.972	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	1.392486e-01	0.856	0	0
Formation of apoptosome	R-HSA-111458	1.392486e-01	0.856	0	0
Ribosome-associated quality control	R-HSA-9948299	1.419505e-01	0.848	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	1.497725e-01	0.825	0	0
Regulation of the apoptosome activity	R-HSA-9627069	1.392486e-01	0.856	0	0
Activation of NOXA and translocation to mitochondria	R-HSA-111448	1.195143e-01	0.923	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	1.075774e-01	0.968	0	0
Cyclin D associated events in G1	R-HSA-69231	1.478097e-01	0.830	0	0
G1 Phase	R-HSA-69236	1.478097e-01	0.830	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	1.075774e-01	0.968	0	0
ERK/MAPK targets	R-HSA-198753	1.180459e-01	0.928	1	1
PCP/CE pathway	R-HSA-4086400	1.505042e-01	0.822	0	0
Regulation of TP53 Degradation	R-HSA-6804757	1.378602e-01	0.861	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	1.524521e-01	0.817	0	0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	1.528707e-01	0.816	0	0
GP1b-IX-V activation signalling	R-HSA-430116	1.173438e-01	0.931	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	1.586807e-01	0.799	1	0
Developmental Cell Lineages	R-HSA-9734767	1.457176e-01	0.836	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	1.247016e-01	0.904	1	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	1.586807e-01	0.799	1	0
Signaling by SCF-KIT	R-HSA-1433557	1.371333e-01	0.863	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	1.384637e-01	0.859	0	0
MTF1 activates gene expression	R-HSA-5660489	1.195143e-01	0.923	0	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	1.195143e-01	0.923	0	0
SMAC (DIABLO) binds to IAPs	R-HSA-111463	1.528707e-01	0.816	0	0
Unwinding of DNA	R-HSA-176974	1.173438e-01	0.931	0	0
DCC mediated attractive signaling	R-HSA-418885	1.213181e-01	0.916	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	1.156295e-01	0.937	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	1.559615e-01	0.807	0	0
Mitochondrial biogenesis	R-HSA-1592230	1.595490e-01	0.797	0	0
Interleukin-17 signaling	R-HSA-448424	1.555777e-01	0.808	1	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	1.496182e-01	0.825	0	0
Regulation of MITF-M dependent genes involved in invasion	R-HSA-9854909	1.528707e-01	0.816	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	1.321503e-01	0.879	0	0
Basigin interactions	R-HSA-210991	1.180459e-01	0.928	0	0
DNA Damage Bypass	R-HSA-73893	1.167742e-01	0.933	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	1.213181e-01	0.916	0	0
RET signaling	R-HSA-8853659	1.378602e-01	0.861	1	1
Inositol phosphate metabolism	R-HSA-1483249	1.146579e-01	0.941	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	1.311287e-01	0.882	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	1.321503e-01	0.879	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	1.606499e-01	0.794	0	0
Heme signaling	R-HSA-9707616	1.606499e-01	0.794	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	1.647616e-01	0.783	0	0
Regulation of mitotic cell cycle	R-HSA-453276	1.647616e-01	0.783	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	1.656201e-01	0.781	0	0
Cellular response to chemical stress	R-HSA-9711123	1.689830e-01	0.772	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	1.703217e-01	0.769	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	1.717109e-01	0.765	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	1.730249e-01	0.762	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	1.738952e-01	0.760	1	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	1.738952e-01	0.760	1	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	1.753777e-01	0.756	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	1.753777e-01	0.756	0	0
G alpha (z) signalling events	R-HSA-418597	1.764020e-01	0.753	0	0
DNA strand elongation	R-HSA-69190	1.775509e-01	0.751	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	1.793144e-01	0.746	0	0
Drug-mediated inhibition of MET activation	R-HSA-9734091	1.793144e-01	0.746	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.793144e-01	0.746	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.793144e-01	0.746	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.793144e-01	0.746	0	0
TICAM1 deficiency - HSE	R-HSA-5602566	1.793144e-01	0.746	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.793144e-01	0.746	0	0
Inhibition of PKR	R-HSA-169131	1.793144e-01	0.746	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	1.811530e-01	0.742	1	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	1.821261e-01	0.740	0	0
Ca2+ pathway	R-HSA-4086398	1.839032e-01	0.735	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.839032e-01	0.735	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.865938e-01	0.729	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	1.874941e-01	0.727	0	0
Signaling by EGFR	R-HSA-177929	1.874941e-01	0.727	0	0
NRAGE signals death through JNK	R-HSA-193648	1.874941e-01	0.727	0	0
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	1.877468e-01	0.726	0	0
Noncanonical activation of NOTCH3	R-HSA-9017802	1.877468e-01	0.726	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	1.877468e-01	0.726	0	0
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	1.877468e-01	0.726	0	0
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	1.877468e-01	0.726	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	1.884768e-01	0.725	0	0
Activation of ATR in response to replication stress	R-HSA-176187	1.921668e-01	0.716	0	0
GAB1 signalosome	R-HSA-180292	1.949675e-01	0.710	0	0
Apoptotic factor-mediated response	R-HSA-111471	1.949675e-01	0.710	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	1.949675e-01	0.710	0	0
HDMs demethylate histones	R-HSA-3214842	1.952501e-01	0.709	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	1.966013e-01	0.706	1	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	1.966013e-01	0.706	1	0
Co-inhibition by PD-1	R-HSA-389948	1.983729e-01	0.703	0	0
PKMTs methylate histone lysines	R-HSA-3214841	2.009528e-01	0.697	0	0
IRE1alpha activates chaperones	R-HSA-381070	2.058514e-01	0.686	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	2.067452e-01	0.685	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	2.072209e-01	0.684	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	2.116442e-01	0.674	0	0
VLDLR internalisation and degradation	R-HSA-8866427	2.116442e-01	0.674	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	2.116442e-01	0.674	0	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	2.124432e-01	0.673	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	2.124432e-01	0.673	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	2.151266e-01	0.667	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	2.151895e-01	0.667	0	0
The NLRP3 inflammasome	R-HSA-844456	2.151895e-01	0.667	0	0
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	2.235617e-01	0.651	0	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	2.235617e-01	0.651	0	0
Interactions of Tat with host cellular proteins	R-HSA-176034	2.565338e-01	0.591	0	0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway	R-HSA-73930	2.565338e-01	0.591	0	0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.565338e-01	0.591	0	0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	2.565338e-01	0.591	0	0
Signaling by TCF7L2 mutants	R-HSA-5339700	2.565338e-01	0.591	0	0
TRAF3 deficiency - HSE	R-HSA-5602571	2.565338e-01	0.591	0	0
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	2.565338e-01	0.591	0	0
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	3.264917e-01	0.486	0	0
Defective ALG9 causes CDG-1l	R-HSA-4720454	3.264917e-01	0.486	0	0
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.264917e-01	0.486	0	0
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.264917e-01	0.486	0	0
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	3.264917e-01	0.486	0	0
MET activates PI3K/AKT signaling	R-HSA-8851907	2.598307e-01	0.585	0	0
SOS-mediated signalling	R-HSA-112412	2.598307e-01	0.585	0	0
Disinhibition of SNARE formation	R-HSA-114516	2.598307e-01	0.585	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	2.598307e-01	0.585	0	0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	3.898705e-01	0.409	0	0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	3.898705e-01	0.409	0	0
Signalling to STAT3	R-HSA-198745	3.898705e-01	0.409	0	0
Defective SLC7A7 causes lysinuric protein intolerance (LPI)	R-HSA-5660862	3.898705e-01	0.409	0	0
Type I hemidesmosome assembly	R-HSA-446107	2.961514e-01	0.528	0	0
RSK activation	R-HSA-444257	2.961514e-01	0.528	0	0
MET receptor recycling	R-HSA-8875656	2.961514e-01	0.528	0	0
Retrograde neurotrophin signalling	R-HSA-177504	2.635759e-01	0.579	0	0
Lipophagy	R-HSA-9613354	3.321934e-01	0.479	0	0
Interleukin-21 signaling	R-HSA-9020958	3.321934e-01	0.479	0	0
WNT mediated activation of DVL	R-HSA-201688	3.321934e-01	0.479	0	0
5-Phosphoribose 1-diphosphate biosynthesis	R-HSA-73843	3.321934e-01	0.479	0	0
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	4.472886e-01	0.349	0	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	4.472886e-01	0.349	0	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	4.472886e-01	0.349	0	0
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	4.472886e-01	0.349	0	0
Defective LFNG causes SCDO3	R-HSA-5083630	4.472886e-01	0.349	0	0
Signaling by MAP2K mutants	R-HSA-9652169	4.472886e-01	0.349	0	0
Negative regulation of MET activity	R-HSA-6807004	2.359509e-01	0.627	0	0
Processive synthesis on the lagging strand	R-HSA-69183	2.901162e-01	0.537	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	2.901162e-01	0.537	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	2.571596e-01	0.590	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	2.571596e-01	0.590	0	0
Binding and entry of HIV virion	R-HSA-173107	3.676877e-01	0.435	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	3.676877e-01	0.435	0	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	3.168317e-01	0.499	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	2.787254e-01	0.555	0	0
HIV elongation arrest and recovery	R-HSA-167287	2.481488e-01	0.605	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	2.481488e-01	0.605	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	2.665483e-01	0.574	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	3.005605e-01	0.522	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	4.024184e-01	0.395	0	0
G1/S-Specific Transcription	R-HSA-69205	2.546419e-01	0.594	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	3.702396e-01	0.432	0	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	3.702396e-01	0.432	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	3.702396e-01	0.432	0	0
EGFR downregulation	R-HSA-182971	3.041589e-01	0.517	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	2.459079e-01	0.609	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	3.447055e-01	0.463	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	3.447055e-01	0.463	0	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	4.362151e-01	0.360	0	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	4.362151e-01	0.360	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	2.594747e-01	0.586	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	3.966900e-01	0.402	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	3.668586e-01	0.436	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	3.216979e-01	0.493	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	3.034880e-01	0.518	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	2.872456e-01	0.542	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	2.354768e-01	0.628	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	3.014046e-01	0.521	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	3.889685e-01	0.410	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	3.889685e-01	0.410	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	4.228309e-01	0.374	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	3.561690e-01	0.448	0	0
HIV Transcription Initiation	R-HSA-167161	3.561690e-01	0.448	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	3.561690e-01	0.448	0	0
Dual Incision in GG-NER	R-HSA-5696400	3.811109e-01	0.419	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	4.109685e-01	0.386	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	4.109685e-01	0.386	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	4.109685e-01	0.386	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	3.082840e-01	0.511	0	0
Transcription of the HIV genome	R-HSA-167172	3.390970e-01	0.470	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	3.908709e-01	0.408	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	4.255259e-01	0.371	0	0
Nucleotide Excision Repair	R-HSA-5696398	3.736415e-01	0.428	0	0
G1/S Transition	R-HSA-69206	2.289357e-01	0.640	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	2.373636e-01	0.625	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	2.359509e-01	0.627	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	2.473196e-01	0.607	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	3.043909e-01	0.517	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	2.571596e-01	0.590	0	0
Polo-like kinase mediated events	R-HSA-156711	3.966900e-01	0.402	0	0
EPHB-mediated forward signaling	R-HSA-3928662	4.082209e-01	0.389	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	3.676877e-01	0.435	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	3.966900e-01	0.402	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	3.664615e-01	0.436	0	0
Adipogenesis	R-HSA-9843745	3.830335e-01	0.417	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	3.190094e-01	0.496	0	0
Regulation of CDH11 function	R-HSA-9762292	3.676877e-01	0.435	0	0
PI3K/AKT activation	R-HSA-198203	3.676877e-01	0.435	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	2.787254e-01	0.555	0	0
Regulation of Apoptosis	R-HSA-169911	4.004132e-01	0.397	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	2.957858e-01	0.529	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	2.901162e-01	0.537	0	0
Trafficking of AMPA receptors	R-HSA-399719	3.041589e-01	0.517	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	3.005605e-01	0.522	0	0
Stabilization of p53	R-HSA-69541	3.046407e-01	0.516	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	2.625077e-01	0.581	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	2.625077e-01	0.581	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	3.880091e-01	0.411	0	0
Signaling by NOTCH3	R-HSA-9012852	4.297766e-01	0.367	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	4.109685e-01	0.386	0	0
Calcineurin activates NFAT	R-HSA-2025928	3.321934e-01	0.479	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	3.435820e-01	0.464	0	0
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	4.362151e-01	0.360	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	3.966900e-01	0.402	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	3.735089e-01	0.428	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	2.384966e-01	0.623	0	0
Signaling by NOTCH4	R-HSA-9013694	2.957858e-01	0.529	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	2.665483e-01	0.574	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	2.729556e-01	0.564	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	2.729556e-01	0.564	0	0
Platelet calcium homeostasis	R-HSA-418360	2.665483e-01	0.574	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	2.910025e-01	0.536	1	0
CRMPs in Sema3A signaling	R-HSA-399956	2.635759e-01	0.579	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	4.024184e-01	0.395	0	0
RNA Polymerase II Transcription	R-HSA-73857	2.807744e-01	0.552	0	0
Interleukin-23 signaling	R-HSA-9020933	2.961514e-01	0.528	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	3.424858e-01	0.465	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	3.435820e-01	0.464	0	0
Generic Transcription Pathway	R-HSA-212436	3.613238e-01	0.442	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	2.665483e-01	0.574	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	3.435820e-01	0.464	0	0
PERK regulates gene expression	R-HSA-381042	4.004132e-01	0.397	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	3.561690e-01	0.448	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	3.980242e-01	0.400	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	3.005605e-01	0.522	0	0
Translation	R-HSA-72766	3.700364e-01	0.432	0	0
Toll-like Receptor Cascades	R-HSA-168898	4.203557e-01	0.376	1	0
Response of endothelial cells to shear stress	R-HSA-9860931	3.512508e-01	0.454	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	2.694350e-01	0.570	0	0
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	2.565338e-01	0.591	0	0
Transport of connexins along the secretory pathway	R-HSA-190827	2.565338e-01	0.591	0	0
Neurophilin interactions with VEGF and VEGFR	R-HSA-194306	3.264917e-01	0.486	0	0
Regulation of cortical dendrite branching	R-HSA-8985801	3.264917e-01	0.486	0	0
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	3.264917e-01	0.486	0	0
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	3.898705e-01	0.409	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	3.321934e-01	0.479	0	0
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	4.472886e-01	0.349	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	4.472886e-01	0.349	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	2.901162e-01	0.537	0	0
Bicarbonate transporters	R-HSA-425381	4.024184e-01	0.395	0	0
Orc1 removal from chromatin	R-HSA-68949	2.459079e-01	0.609	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	3.908709e-01	0.408	0	0
rRNA processing	R-HSA-72312	3.621631e-01	0.441	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	4.456877e-01	0.351	0	0
Signaling by NOTCH1	R-HSA-1980143	3.209046e-01	0.494	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	4.327969e-01	0.364	0	0
Signaling by ALK	R-HSA-201556	3.046407e-01	0.516	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	3.617861e-01	0.442	0	0
Regulation of CDH11 gene transcription	R-HSA-9762293	3.321934e-01	0.479	0	0
Signal attenuation	R-HSA-74749	3.676877e-01	0.435	0	0
Ovarian tumor domain proteases	R-HSA-5689896	4.387730e-01	0.358	0	0
Circadian clock	R-HSA-9909396	3.931360e-01	0.405	0	0
Neurexins and neuroligins	R-HSA-6794361	3.821264e-01	0.418	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	3.723047e-01	0.429	0	0
Negative regulation of FLT3	R-HSA-9706369	3.168317e-01	0.499	0	0
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	3.321934e-01	0.479	0	0
Activation of the AP-1 family of transcription factors	R-HSA-450341	3.321934e-01	0.479	0	0
Protein hydroxylation	R-HSA-9629569	2.359509e-01	0.627	0	0
p38MAPK events	R-HSA-171007	2.901162e-01	0.537	0	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	2.571596e-01	0.590	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	3.005605e-01	0.522	0	0
Synthesis of PG	R-HSA-1483148	3.435820e-01	0.464	0	0
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	4.362151e-01	0.360	0	0
Post-translational protein modification	R-HSA-597592	4.143069e-01	0.383	0	0
Amine ligand-binding receptors	R-HSA-375280	2.580029e-01	0.588	0	0
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	2.598307e-01	0.585	0	0
RUNX2 regulates bone development	R-HSA-8941326	4.196480e-01	0.377	0	0
Signal transduction by L1	R-HSA-445144	2.359509e-01	0.627	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	3.447055e-01	0.463	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	3.424858e-01	0.465	0	0
TBC/RABGAPs	R-HSA-8854214	3.908709e-01	0.408	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	2.591774e-01	0.586	0	0
Transmission across Chemical Synapses	R-HSA-112315	3.172849e-01	0.499	0	0
Signaling by TGFB family members	R-HSA-9006936	2.360765e-01	0.627	0	0
Oligomerization of connexins into connexons	R-HSA-190704	2.565338e-01	0.591	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	2.373636e-01	0.625	0	0
Cellular response to mitochondrial stress	R-HSA-9840373	3.321934e-01	0.479	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	3.321934e-01	0.479	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	2.901162e-01	0.537	0	0
Josephin domain DUBs	R-HSA-5689877	3.676877e-01	0.435	0	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	3.676877e-01	0.435	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	2.732615e-01	0.563	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	3.424858e-01	0.465	0	0
G alpha (12/13) signalling events	R-HSA-416482	2.358540e-01	0.627	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	3.617861e-01	0.442	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	4.109685e-01	0.386	0	0
Netrin-1 signaling	R-HSA-373752	2.580029e-01	0.588	0	0
Inflammasomes	R-HSA-622312	2.481488e-01	0.605	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	3.664615e-01	0.436	0	0
Amyloid fiber formation	R-HSA-977225	2.694181e-01	0.570	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	2.965463e-01	0.528	0	0
Gluconeogenesis	R-HSA-70263	3.190094e-01	0.496	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	2.712175e-01	0.567	1	0
Histamine receptors	R-HSA-390650	3.898705e-01	0.409	0	0
Suppression of apoptosis	R-HSA-9635465	4.024184e-01	0.395	0	0
DAG and IP3 signaling	R-HSA-1489509	2.729556e-01	0.564	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	3.424858e-01	0.465	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	3.287365e-01	0.483	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	3.966900e-01	0.402	0	0
Reproduction	R-HSA-1474165	2.812604e-01	0.551	0	0
Syndecan interactions	R-HSA-3000170	3.225807e-01	0.491	0	0
Co-stimulation by CD28	R-HSA-389356	3.190094e-01	0.496	0	0
The NLRP1 inflammasome	R-HSA-844455	3.898705e-01	0.409	0	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	3.676877e-01	0.435	0	0
Signaling by PDGFR in disease	R-HSA-9671555	2.787254e-01	0.555	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	3.388865e-01	0.470	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	3.702396e-01	0.432	0	0
Pyroptosis	R-HSA-5620971	2.481488e-01	0.605	0	0
Signaling by NTRKs	R-HSA-166520	2.910025e-01	0.536	1	0
Death Receptor Signaling	R-HSA-73887	4.353810e-01	0.361	0	0
ATF6B (ATF6-beta) activates chaperones	R-HSA-8874177	3.264917e-01	0.486	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	2.635759e-01	0.579	0	0
Respiratory syncytial virus genome replication	R-HSA-9834752	3.321934e-01	0.479	0	0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	2.901162e-01	0.537	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	3.702396e-01	0.432	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	4.455817e-01	0.351	0	0
Interleukin-7 signaling	R-HSA-1266695	3.668586e-01	0.436	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	3.595005e-01	0.444	0	0
Interleukin-1 family signaling	R-HSA-446652	4.162619e-01	0.381	0	0
ChREBP activates metabolic gene expression	R-HSA-163765	4.024184e-01	0.395	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	3.223128e-01	0.492	0	0
Growth hormone receptor signaling	R-HSA-982772	3.225807e-01	0.491	0	0
TRP channels	R-HSA-3295583	3.889685e-01	0.410	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	2.354768e-01	0.628	0	0
Selenoamino acid metabolism	R-HSA-2408522	4.360471e-01	0.360	0	0
Mismatch Repair	R-HSA-5358508	3.966900e-01	0.402	0	0
SARS-CoV Infections	R-HSA-9679506	4.072725e-01	0.390	0	0
SARS-CoV-2 Infection	R-HSA-9694516	2.982703e-01	0.525	0	0
SARS-CoV-1 Infection	R-HSA-9678108	2.868457e-01	0.542	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	3.966900e-01	0.402	0	0
G-protein mediated events	R-HSA-112040	4.622976e-01	0.335	0	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	4.689461e-01	0.329	0	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	4.689461e-01	0.329	0	0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	4.689461e-01	0.329	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	4.689461e-01	0.329	0	0
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	4.689461e-01	0.329	0	0
p75NTR recruits signalling complexes	R-HSA-209543	4.689461e-01	0.329	0	0
Polymerase switching	R-HSA-69091	4.689461e-01	0.329	0	0
Leading Strand Synthesis	R-HSA-69109	4.689461e-01	0.329	0	0
OAS antiviral response	R-HSA-8983711	4.689461e-01	0.329	0	0
MAPK family signaling cascades	R-HSA-5683057	4.732783e-01	0.325	0	0
Lagging Strand Synthesis	R-HSA-69186	4.738358e-01	0.324	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	4.738358e-01	0.324	0	0
Signalling to RAS	R-HSA-167044	4.738358e-01	0.324	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	4.757174e-01	0.323	0	0
Pentose phosphate pathway	R-HSA-71336	4.765380e-01	0.322	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	4.765380e-01	0.322	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	4.765380e-01	0.322	0	0
Dual incision in TC-NER	R-HSA-6782135	4.769327e-01	0.322	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	4.883503e-01	0.311	0	0
Extension of Telomeres	R-HSA-180786	4.924354e-01	0.308	0	0
Degradation of CDH1	R-HSA-9766229	4.936962e-01	0.307	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	4.951067e-01	0.305	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	4.951067e-01	0.305	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	4.951067e-01	0.305	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	4.951067e-01	0.305	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	4.967113e-01	0.304	0	0
Cargo concentration in the ER	R-HSA-5694530	4.967113e-01	0.304	0	0
Downstream signal transduction	R-HSA-186763	4.967113e-01	0.304	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	4.985538e-01	0.302	0	0
FGFR1c and Klotho ligand binding and activation	R-HSA-190374	4.993062e-01	0.302	0	0
FLT3 signaling by CBL mutants	R-HSA-9706377	4.993062e-01	0.302	0	0
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	4.993062e-01	0.302	0	0
PTK6 Activates STAT3	R-HSA-8849474	4.993062e-01	0.302	0	0
Post-transcriptional silencing by small RNAs	R-HSA-426496	4.993062e-01	0.302	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	4.993062e-01	0.302	0	0
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	4.993062e-01	0.302	0	0
Muscarinic acetylcholine receptors	R-HSA-390648	4.993062e-01	0.302	0	0
Inositol transporters	R-HSA-429593	4.993062e-01	0.302	0	0
Nectin/Necl trans heterodimerization	R-HSA-420597	4.993062e-01	0.302	0	0
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	4.993062e-01	0.302	0	0
Assembly of Viral Components at the Budding Site	R-HSA-168316	4.993062e-01	0.302	0	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	5.005127e-01	0.301	0	0
PDH complex synthesizes acetyl-CoA from PYR	R-HSA-9861559	5.005127e-01	0.301	0	0
FGFR1c ligand binding and activation	R-HSA-190373	5.005127e-01	0.301	0	0
Interleukin-6 signaling	R-HSA-1059683	5.005127e-01	0.301	0	0
CD28 dependent Vav1 pathway	R-HSA-389359	5.005127e-01	0.301	0	0
ER-Phagosome pathway	R-HSA-1236974	5.020464e-01	0.299	0	0
Asparagine N-linked glycosylation	R-HSA-446203	5.068001e-01	0.295	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	5.077957e-01	0.294	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	5.077957e-01	0.294	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	5.077957e-01	0.294	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	5.077957e-01	0.294	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	5.077957e-01	0.294	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	5.119419e-01	0.291	0	0
Regulation of insulin secretion	R-HSA-422356	5.126258e-01	0.290	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	5.134235e-01	0.290	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	5.134235e-01	0.290	0	0
LDL clearance	R-HSA-8964038	5.226691e-01	0.282	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	5.226691e-01	0.282	0	0
PLC beta mediated events	R-HSA-112043	5.229950e-01	0.282	0	0
Removal of the Flap Intermediate	R-HSA-69166	5.308442e-01	0.275	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	5.308442e-01	0.275	0	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	5.308442e-01	0.275	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	5.308442e-01	0.275	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	5.308442e-01	0.275	0	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	5.308442e-01	0.275	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	5.308442e-01	0.275	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	5.314595e-01	0.275	0	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	5.338950e-01	0.273	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	5.375583e-01	0.270	0	0
G-protein beta:gamma signalling	R-HSA-397795	5.375583e-01	0.270	0	0
Nuclear RNA decay	R-HSA-9930044	5.375583e-01	0.270	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	5.375583e-01	0.270	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	5.375583e-01	0.270	0	0
Signaling by PDGF	R-HSA-186797	5.380155e-01	0.269	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	5.429831e-01	0.265	0	0
Cytoprotection by HMOX1	R-HSA-9707564	5.435227e-01	0.265	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	5.461341e-01	0.263	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	5.461341e-01	0.263	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	5.461341e-01	0.263	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	5.461341e-01	0.263	0	0
Plus-strand DNA synthesis	R-HSA-164525	5.464311e-01	0.262	0	0
Nef Mediated CD8 Down-regulation	R-HSA-182218	5.464311e-01	0.262	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	5.464311e-01	0.262	0	0
PTK6 Regulates Cell Cycle	R-HSA-8849470	5.464311e-01	0.262	0	0
Phosphorylation of Emi1	R-HSA-176417	5.464311e-01	0.262	0	0
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	5.464311e-01	0.262	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	5.464311e-01	0.262	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	5.464311e-01	0.262	0	0
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	5.464311e-01	0.262	0	0
Loss-of-function mutations in DBT cause MSUD2	R-HSA-9865113	5.464311e-01	0.262	0	0
Loss-of-function mutations in DLD cause MSUD3/DLDD	R-HSA-9907570	5.464311e-01	0.262	0	0
Defective CSF2RA causes SMDP4	R-HSA-5688890	5.464311e-01	0.262	0	0
Signaling by RNF43 mutants	R-HSA-5340588	5.464311e-01	0.262	0	0
Defective CSF2RB causes SMDP5	R-HSA-5688849	5.464311e-01	0.262	0	0
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	5.464311e-01	0.262	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	5.464311e-01	0.262	0	0
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	5.464311e-01	0.262	0	0
VEGF binds to VEGFR leading to receptor dimerization	R-HSA-195399	5.464311e-01	0.262	0	0
Release of apoptotic factors from the mitochondria	R-HSA-111457	5.464311e-01	0.262	0	0
VEGF ligand-receptor interactions	R-HSA-194313	5.464311e-01	0.262	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	5.464311e-01	0.262	0	0
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	5.464311e-01	0.262	0	0
Integration of energy metabolism	R-HSA-163685	5.467868e-01	0.262	0	0
Interleukin-1 signaling	R-HSA-9020702	5.483797e-01	0.261	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	5.491888e-01	0.260	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	5.527798e-01	0.257	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	5.528408e-01	0.257	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	5.589413e-01	0.253	0	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	5.598935e-01	0.252	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	5.598935e-01	0.252	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	5.598935e-01	0.252	0	0
Adenylate cyclase inhibitory pathway	R-HSA-170670	5.598935e-01	0.252	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	5.598935e-01	0.252	0	0
p75NTR signals via NF-kB	R-HSA-193639	5.598935e-01	0.252	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	5.598935e-01	0.252	0	0
Signaling by FGFR in disease	R-HSA-1226099	5.615330e-01	0.251	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	5.674558e-01	0.246	0	0
Protein-protein interactions at synapses	R-HSA-6794362	5.693591e-01	0.245	0	0
Mitochondrial protein degradation	R-HSA-9837999	5.765133e-01	0.239	0	0
RAF activation	R-HSA-5673000	5.766609e-01	0.239	0	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	5.766609e-01	0.239	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	5.766609e-01	0.239	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	5.766609e-01	0.239	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	5.836367e-01	0.234	0	0
RMTs methylate histone arginines	R-HSA-3214858	5.836367e-01	0.234	0	0
Hemostasis	R-HSA-109582	5.861765e-01	0.232	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	5.876332e-01	0.231	0	0
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	5.876332e-01	0.231	0	0
Activation of SMO	R-HSA-5635838	5.876332e-01	0.231	0	0
Killing mechanisms	R-HSA-9664420	5.876332e-01	0.231	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	5.876332e-01	0.231	0	0
Differentiation of T cells	R-HSA-9945266	5.876332e-01	0.231	0	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	5.876332e-01	0.231	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	5.876332e-01	0.231	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	5.891232e-01	0.230	0	0
Signaling by LTK in cancer	R-HSA-9842640	5.891232e-01	0.230	0	0
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	5.891232e-01	0.230	0	0
Erythropoietin activates STAT5	R-HSA-9027283	5.891232e-01	0.230	0	0
Uncoating of the HIV Virion	R-HSA-162585	5.891232e-01	0.230	0	0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD	R-HSA-9865125	5.891232e-01	0.230	0	0
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	5.891232e-01	0.230	0	0
Defective CYP11A1 causes AICSR	R-HSA-5579026	5.891232e-01	0.230	0	0
H139Hfs13* PPM1K causes a mild variant of MSUD	R-HSA-9912529	5.891232e-01	0.230	0	0
MET Receptor Activation	R-HSA-6806942	5.891232e-01	0.230	0	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	5.891232e-01	0.230	0	0
G2/M DNA replication checkpoint	R-HSA-69478	5.891232e-01	0.230	0	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	5.891232e-01	0.230	0	0
VLDL assembly	R-HSA-8866423	5.891232e-01	0.230	0	0
Nef and signal transduction	R-HSA-164944	5.891232e-01	0.230	0	0
Tight junction interactions	R-HSA-420029	5.909660e-01	0.228	0	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	5.909660e-01	0.228	0	0
Potential therapeutics for SARS	R-HSA-9679191	5.921500e-01	0.228	0	0
tRNA processing	R-HSA-72306	5.938670e-01	0.226	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	5.954910e-01	0.225	0	0
Signalling to ERKs	R-HSA-187687	5.954910e-01	0.225	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	6.003163e-01	0.222	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	6.003163e-01	0.222	0	0
Ion homeostasis	R-HSA-5578775	6.051556e-01	0.218	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	6.051556e-01	0.218	0	0
Pyruvate metabolism	R-HSA-70268	6.068680e-01	0.217	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	6.107508e-01	0.214	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	6.122790e-01	0.213	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	6.122790e-01	0.213	0	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	6.122790e-01	0.213	0	0
FLT3 signaling in disease	R-HSA-9682385	6.138127e-01	0.212	0	0
Calmodulin induced events	R-HSA-111933	6.138127e-01	0.212	0	0
CaM pathway	R-HSA-111997	6.138127e-01	0.212	0	0
G beta:gamma signalling through CDC42	R-HSA-8964616	6.140526e-01	0.212	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	6.140526e-01	0.212	0	0
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	6.140526e-01	0.212	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	6.140526e-01	0.212	0	0
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	6.140526e-01	0.212	0	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	6.140526e-01	0.212	0	0
Response to metal ions	R-HSA-5660526	6.140526e-01	0.212	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	6.145242e-01	0.211	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	6.166111e-01	0.210	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	6.166111e-01	0.210	0	0
Regulation of pyruvate metabolism	R-HSA-9861718	6.166111e-01	0.210	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	6.166111e-01	0.210	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	6.166111e-01	0.210	0	0
Regulated Necrosis	R-HSA-5218859	6.235498e-01	0.205	0	0
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	6.277991e-01	0.202	0	0
TRIF-mediated programmed cell death	R-HSA-2562578	6.277991e-01	0.202	0	0
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2	R-HSA-964827	6.277991e-01	0.202	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	6.277991e-01	0.202	0	0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	6.277991e-01	0.202	0	0
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	6.277991e-01	0.202	0	0
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	6.277991e-01	0.202	0	0
Recycling of eIF2:GDP	R-HSA-72731	6.277991e-01	0.202	0	0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	6.277991e-01	0.202	0	0
Electron transport from NADPH to Ferredoxin	R-HSA-2395516	6.277991e-01	0.202	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	6.277991e-01	0.202	0	0
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	6.277991e-01	0.202	0	0
NOSTRIN mediated eNOS trafficking	R-HSA-203641	6.277991e-01	0.202	0	0
PTK6 Expression	R-HSA-8849473	6.277991e-01	0.202	0	0
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	6.277991e-01	0.202	0	0
Nef Mediated CD4 Down-regulation	R-HSA-167590	6.277991e-01	0.202	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	6.277991e-01	0.202	0	0
VLDL clearance	R-HSA-8964046	6.277991e-01	0.202	0	0
LDL remodeling	R-HSA-8964041	6.277991e-01	0.202	0	0
Cation-coupled Chloride cotransporters	R-HSA-426117	6.277991e-01	0.202	0	0
Regulation of PTEN localization	R-HSA-8948747	6.277991e-01	0.202	0	0
CHL1 interactions	R-HSA-447041	6.277991e-01	0.202	0	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	6.277991e-01	0.202	0	0
Degradation of DVL	R-HSA-4641258	6.316099e-01	0.200	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	6.325078e-01	0.199	0	0
Insulin processing	R-HSA-264876	6.328323e-01	0.199	0	0
Antigen processing-Cross presentation	R-HSA-1236975	6.382594e-01	0.195	0	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	6.391544e-01	0.194	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	6.391544e-01	0.194	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	6.391544e-01	0.194	0	0
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	6.391544e-01	0.194	0	0
Specification of primordial germ cells	R-HSA-9827857	6.391544e-01	0.194	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	6.391544e-01	0.194	0	0
Signaling by MET	R-HSA-6806834	6.397164e-01	0.194	0	0
Signaling by FGFR2	R-HSA-5654738	6.397164e-01	0.194	0	0
MET promotes cell motility	R-HSA-8875878	6.488703e-01	0.188	0	0
COPII-mediated vesicle transport	R-HSA-204005	6.500264e-01	0.187	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	6.526153e-01	0.185	0	0
Formation of the Early Elongation Complex	R-HSA-113418	6.526153e-01	0.185	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	6.526153e-01	0.185	0	0
Telomere Extension By Telomerase	R-HSA-171319	6.526153e-01	0.185	0	0
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	6.526153e-01	0.185	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	6.580648e-01	0.182	0	0
RAB geranylgeranylation	R-HSA-8873719	6.624079e-01	0.179	0	0
Reverse Transcription of HIV RNA	R-HSA-162589	6.628366e-01	0.179	0	0
Minus-strand DNA synthesis	R-HSA-164516	6.628366e-01	0.179	0	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	6.628366e-01	0.179	0	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	6.628366e-01	0.179	0	0
Activated NTRK2 signals through PI3K	R-HSA-9028335	6.628366e-01	0.179	0	0
Myoclonic epilepsy of Lafora	R-HSA-3785653	6.628366e-01	0.179	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	6.628366e-01	0.179	0	0
Regulation of NPAS4 mRNA translation	R-HSA-9768778	6.628366e-01	0.179	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	6.628366e-01	0.179	0	0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	6.628366e-01	0.179	0	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	6.628366e-01	0.179	0	0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	6.628366e-01	0.179	0	0
Axonal growth inhibition (RHOA activation)	R-HSA-193634	6.628366e-01	0.179	0	0
Co-stimulation by ICOS	R-HSA-9927354	6.628366e-01	0.179	0	0
FGFR1b ligand binding and activation	R-HSA-190370	6.628366e-01	0.179	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	6.628366e-01	0.179	0	0
Interleukin-9 signaling	R-HSA-8985947	6.628366e-01	0.179	0	0
TGFBR3 PTM regulation	R-HSA-9839383	6.628366e-01	0.179	0	0
SLC-mediated bile acid transport	R-HSA-9958517	6.628366e-01	0.179	0	0
Sodium/Proton exchangers	R-HSA-425986	6.628366e-01	0.179	0	0
Hedgehog 'on' state	R-HSA-5632684	6.628423e-01	0.179	0	0
G beta:gamma signalling through PLC beta	R-HSA-418217	6.629525e-01	0.179	0	0
FGFR1 ligand binding and activation	R-HSA-190242	6.629525e-01	0.179	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	6.629525e-01	0.179	0	0
Presynaptic function of Kainate receptors	R-HSA-500657	6.629525e-01	0.179	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	6.655845e-01	0.177	0	0
Plasma lipoprotein clearance	R-HSA-8964043	6.655845e-01	0.177	0	0
Signaling by Erythropoietin	R-HSA-9006335	6.716229e-01	0.173	0	0
mRNA Capping	R-HSA-72086	6.716229e-01	0.173	0	0
Metabolism of proteins	R-HSA-392499	6.754199e-01	0.170	0	0
Regulation of RAS by GAPs	R-HSA-5658442	6.777065e-01	0.169	0	0
HIV Transcription Elongation	R-HSA-167169	6.817463e-01	0.166	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	6.817463e-01	0.166	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	6.817463e-01	0.166	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	6.817463e-01	0.166	0	0
Diseases of Immune System	R-HSA-5260271	6.817463e-01	0.166	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	6.817463e-01	0.166	0	0
Pre-NOTCH Processing in Golgi	R-HSA-1912420	6.854699e-01	0.164	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	6.854699e-01	0.164	0	0
Regulation of signaling by CBL	R-HSA-912631	6.854699e-01	0.164	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	6.854699e-01	0.164	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	6.854699e-01	0.164	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	6.854699e-01	0.164	0	0
Rap1 signalling	R-HSA-392517	6.854699e-01	0.164	0	0
Other interleukin signaling	R-HSA-449836	6.854699e-01	0.164	0	0
Maturation of nucleoprotein	R-HSA-9694631	6.854699e-01	0.164	0	0
STING mediated induction of host immune responses	R-HSA-1834941	6.854699e-01	0.164	0	0
Mitochondrial protein import	R-HSA-1268020	6.889943e-01	0.162	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	6.898546e-01	0.161	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	6.919184e-01	0.160	0	0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	6.945776e-01	0.158	0	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	6.945776e-01	0.158	0	0
p75NTR regulates axonogenesis	R-HSA-193697	6.945776e-01	0.158	0	0
Regulation of signaling by NODAL	R-HSA-1433617	6.945776e-01	0.158	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	6.945776e-01	0.158	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	6.945776e-01	0.158	0	0
Interleukin-1 processing	R-HSA-448706	6.945776e-01	0.158	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	6.973522e-01	0.157	0	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	6.973522e-01	0.157	0	0
RAF/MAP kinase cascade	R-HSA-5673001	7.030112e-01	0.153	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	7.056958e-01	0.151	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	7.056958e-01	0.151	0	0
Neuronal System	R-HSA-112316	7.058518e-01	0.151	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	7.067368e-01	0.151	0	0
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	7.067368e-01	0.151	0	0
Glycogen synthesis	R-HSA-3322077	7.067368e-01	0.151	0	0
Budding and maturation of HIV virion	R-HSA-162588	7.073144e-01	0.150	0	0
Protein localization	R-HSA-9609507	7.119573e-01	0.148	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	7.124012e-01	0.147	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	7.124012e-01	0.147	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	7.124012e-01	0.147	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	7.124012e-01	0.147	0	0
Nucleotide biosynthesis	R-HSA-8956320	7.190368e-01	0.143	0	0
Adaptive Immune System	R-HSA-1280218	7.215216e-01	0.142	0	0
MAPK3 (ERK1) activation	R-HSA-110056	7.233322e-01	0.141	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	7.233322e-01	0.141	0	0
DNA replication initiation	R-HSA-68952	7.233322e-01	0.141	0	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	7.233322e-01	0.141	0	0
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	7.233322e-01	0.141	0	0
Formation of intermediate mesoderm	R-HSA-9761174	7.233322e-01	0.141	0	0
Pexophagy	R-HSA-9664873	7.233322e-01	0.141	0	0
Interleukin-27 signaling	R-HSA-9020956	7.233322e-01	0.141	0	0
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	7.233322e-01	0.141	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	7.233322e-01	0.141	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	7.233322e-01	0.141	0	0
Signaling by WNT in cancer	R-HSA-4791275	7.240095e-01	0.140	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	7.240095e-01	0.140	0	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	7.267889e-01	0.139	0	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	7.267889e-01	0.139	0	0
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	7.267889e-01	0.139	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	7.267889e-01	0.139	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	7.267889e-01	0.139	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	7.267889e-01	0.139	0	0
Interferon alpha/beta signaling	R-HSA-909733	7.268180e-01	0.139	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	7.268945e-01	0.139	0	0
Ca-dependent events	R-HSA-111996	7.268945e-01	0.139	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	7.286158e-01	0.138	0	0
SLC transporter disorders	R-HSA-5619102	7.361196e-01	0.133	0	0
Integrin signaling	R-HSA-354192	7.399509e-01	0.131	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	7.408356e-01	0.130	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	7.408356e-01	0.130	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	7.443155e-01	0.128	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	7.456666e-01	0.127	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	7.456666e-01	0.127	0	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	7.456666e-01	0.127	0	0
Ribavirin ADME	R-HSA-9755088	7.456666e-01	0.127	0	0
Post-translational protein phosphorylation	R-HSA-8957275	7.477781e-01	0.126	0	0
Signaling by FGFR	R-HSA-190236	7.477781e-01	0.126	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	7.492180e-01	0.125	0	0
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	7.493812e-01	0.125	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	7.493812e-01	0.125	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	7.493812e-01	0.125	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	7.493812e-01	0.125	0	0
Presynaptic depolarization and calcium channel opening	R-HSA-112308	7.493812e-01	0.125	0	0
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	7.493812e-01	0.125	0	0
vRNP Assembly	R-HSA-192905	7.493812e-01	0.125	0	0
Signaling by APC mutants	R-HSA-4839744	7.493812e-01	0.125	0	0
Chylomicron assembly	R-HSA-8963888	7.493812e-01	0.125	0	0
RHOBTB3 ATPase cycle	R-HSA-9706019	7.493812e-01	0.125	0	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	7.493812e-01	0.125	0	0
SARS-CoV-2 modulates autophagy	R-HSA-9754560	7.493812e-01	0.125	0	0
PECAM1 interactions	R-HSA-210990	7.493812e-01	0.125	0	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	7.493812e-01	0.125	0	0
Dissolution of Fibrin Clot	R-HSA-75205	7.493812e-01	0.125	0	0
Proteasome assembly	R-HSA-9907900	7.542295e-01	0.122	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	7.551517e-01	0.122	0	0
Glutamate and glutamine metabolism	R-HSA-8964539	7.551517e-01	0.122	0	0
Vpu mediated degradation of CD4	R-HSA-180534	7.551517e-01	0.122	0	0
Miscellaneous transport and binding events	R-HSA-5223345	7.551517e-01	0.122	0	0
TNF signaling	R-HSA-75893	7.564447e-01	0.121	0	0
FOXO-mediated transcription	R-HSA-9614085	7.570020e-01	0.121	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	7.634131e-01	0.117	0	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.634131e-01	0.117	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	7.634131e-01	0.117	0	0
Signaling by KIT in disease	R-HSA-9669938	7.634131e-01	0.117	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	7.670831e-01	0.115	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	7.670831e-01	0.115	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	7.670831e-01	0.115	0	0
Signaling by NOTCH2	R-HSA-1980145	7.696279e-01	0.114	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	7.696279e-01	0.114	0	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	7.696279e-01	0.114	0	0
Mitophagy	R-HSA-5205647	7.696279e-01	0.114	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	7.696279e-01	0.114	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	7.729790e-01	0.112	0	0
Synthesis of diphthamide-EEF2	R-HSA-5358493	7.729790e-01	0.112	0	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	7.729790e-01	0.112	0	0
ERKs are inactivated	R-HSA-202670	7.729790e-01	0.112	1	1
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	7.729790e-01	0.112	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	7.729790e-01	0.112	0	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	7.729790e-01	0.112	0	0
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	7.729790e-01	0.112	0	0
NF-kB is activated and signals survival	R-HSA-209560	7.729790e-01	0.112	0	0
Signaling by activated point mutants of FGFR1	R-HSA-1839122	7.729790e-01	0.112	0	0
Plasmalogen biosynthesis	R-HSA-75896	7.729790e-01	0.112	0	0
Signaling by AMER1 mutants	R-HSA-4839748	7.729790e-01	0.112	0	0
Signaling by AXIN mutants	R-HSA-4839735	7.729790e-01	0.112	0	0
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	7.729790e-01	0.112	0	0
Endosomal/Vacuolar pathway	R-HSA-1236977	7.729790e-01	0.112	0	0
Integration of provirus	R-HSA-162592	7.729790e-01	0.112	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	7.792296e-01	0.108	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	7.794048e-01	0.108	0	0
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	7.800741e-01	0.108	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	7.800741e-01	0.108	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	7.810471e-01	0.107	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	7.811609e-01	0.107	0	0
Infectious disease	R-HSA-5663205	7.824953e-01	0.107	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	7.833970e-01	0.106	0	0
MET activates RAS signaling	R-HSA-8851805	7.943561e-01	0.100	0	0
Maple Syrup Urine Disease	R-HSA-9865114	7.943561e-01	0.100	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	7.943561e-01	0.100	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	7.943561e-01	0.100	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	7.943561e-01	0.100	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	7.943561e-01	0.100	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	7.943561e-01	0.100	0	0
GRB2 events in EGFR signaling	R-HSA-179812	7.943561e-01	0.100	0	0
Serotonin clearance from the synaptic cleft	R-HSA-380615	7.943561e-01	0.100	0	0
Signaling by LTK	R-HSA-9842663	7.943561e-01	0.100	0	0
Interleukin-15 signaling	R-HSA-8983432	7.943561e-01	0.100	0	0
Trafficking and processing of endosomal TLR	R-HSA-1679131	7.943561e-01	0.100	0	0
Diseases associated with surfactant metabolism	R-HSA-5687613	7.943561e-01	0.100	0	0
Role of second messengers in netrin-1 signaling	R-HSA-418890	7.943561e-01	0.100	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	7.943561e-01	0.100	0	0
Pervasive developmental disorders	R-HSA-9005895	7.943561e-01	0.100	0	0
Disorders of Nervous System Development	R-HSA-9697154	7.943561e-01	0.100	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	7.943561e-01	0.100	0	0
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	7.943561e-01	0.100	0	0
Interleukin-35 Signalling	R-HSA-8984722	7.943561e-01	0.100	0	0
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	7.943561e-01	0.100	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	7.956966e-01	0.099	0	0
Interleukin-6 family signaling	R-HSA-6783589	7.956966e-01	0.099	0	0
Complex III assembly	R-HSA-9865881	7.956966e-01	0.099	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	7.956966e-01	0.099	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	7.964783e-01	0.099	0	0
RNA Polymerase III Transcription	R-HSA-74158	7.964783e-01	0.099	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	7.964783e-01	0.099	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	7.964783e-01	0.099	0	0
Opioid Signalling	R-HSA-111885	7.995582e-01	0.097	0	0
NGF-stimulated transcription	R-HSA-9031628	8.024916e-01	0.096	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	8.044431e-01	0.095	0	0
Degradation of AXIN	R-HSA-4641257	8.088922e-01	0.092	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	8.088922e-01	0.092	0	0
NCAM1 interactions	R-HSA-419037	8.088922e-01	0.092	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	8.102754e-01	0.091	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	8.103283e-01	0.091	0	0
Long-term potentiation	R-HSA-9620244	8.103283e-01	0.091	0	0
Acyl chain remodelling of PS	R-HSA-1482801	8.103283e-01	0.091	0	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	8.103283e-01	0.091	0	0
Extracellular matrix organization	R-HSA-1474244	8.116840e-01	0.091	0	0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	8.137214e-01	0.090	0	0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	8.137214e-01	0.090	0	0
Adenylate cyclase activating pathway	R-HSA-170660	8.137214e-01	0.090	0	0
FGFR2c ligand binding and activation	R-HSA-190375	8.137214e-01	0.090	0	0
Formation of axial mesoderm	R-HSA-9796292	8.137214e-01	0.090	0	0
FGFR4 ligand binding and activation	R-HSA-190322	8.137214e-01	0.090	0	0
Signaling by activated point mutants of FGFR3	R-HSA-1839130	8.137214e-01	0.090	0	0
Frs2-mediated activation	R-HSA-170968	8.137214e-01	0.090	0	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	8.137214e-01	0.090	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	8.137214e-01	0.090	0	0
FGFR3 mutant receptor activation	R-HSA-2033514	8.137214e-01	0.090	0	0
Processing of SMDT1	R-HSA-8949664	8.137214e-01	0.090	0	0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	8.137214e-01	0.090	0	0
Maturation of nucleoprotein	R-HSA-9683610	8.137214e-01	0.090	0	0
Replication of the SARS-CoV-1 genome	R-HSA-9682706	8.137214e-01	0.090	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	8.189477e-01	0.087	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	8.190283e-01	0.087	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	8.198164e-01	0.086	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	8.206604e-01	0.086	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	8.206604e-01	0.086	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	8.235788e-01	0.084	0	0
Azathioprine ADME	R-HSA-9748787	8.235788e-01	0.084	0	0
PI3K Cascade	R-HSA-109704	8.235788e-01	0.084	0	0
Metalloprotease DUBs	R-HSA-5689901	8.240174e-01	0.084	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	8.240174e-01	0.084	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	8.240174e-01	0.084	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	8.289671e-01	0.081	0	0
FGFR3c ligand binding and activation	R-HSA-190372	8.312642e-01	0.080	0	0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV	R-HSA-9859138	8.312642e-01	0.080	0	0
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	8.312642e-01	0.080	0	0
N-glycan trimming and elongation in the cis-Golgi	R-HSA-964739	8.312642e-01	0.080	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	8.312642e-01	0.080	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	8.312642e-01	0.080	0	0
Formation of the active cofactor, UDP-glucuronate	R-HSA-173599	8.312642e-01	0.080	0	0
Prolactin receptor signaling	R-HSA-1170546	8.312642e-01	0.080	0	0
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.312642e-01	0.080	0	0
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	8.312642e-01	0.080	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	8.318051e-01	0.080	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	8.318051e-01	0.080	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	8.334038e-01	0.079	0	0
Cristae formation	R-HSA-8949613	8.368115e-01	0.077	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	8.368115e-01	0.077	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	8.368115e-01	0.077	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	8.368115e-01	0.077	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	8.368115e-01	0.077	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	8.368115e-01	0.077	0	0
Maturation of hRSV A proteins	R-HSA-9828806	8.368115e-01	0.077	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	8.381743e-01	0.077	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	8.423490e-01	0.075	0	0
Interleukin-2 family signaling	R-HSA-451927	8.423490e-01	0.075	0	0
Generation of second messenger molecules	R-HSA-202433	8.423490e-01	0.075	0	0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	8.471558e-01	0.072	0	0
Erythropoietin activates RAS	R-HSA-9027284	8.471558e-01	0.072	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	8.471558e-01	0.072	0	0
SHC1 events in EGFR signaling	R-HSA-180336	8.471558e-01	0.072	0	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	8.471558e-01	0.072	0	0
G beta:gamma signalling through BTK	R-HSA-8964315	8.471558e-01	0.072	0	0
RNA Polymerase III Chain Elongation	R-HSA-73780	8.471558e-01	0.072	0	0
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	8.471558e-01	0.072	0	0
Telomere C-strand synthesis initiation	R-HSA-174430	8.471558e-01	0.072	0	0
FGFR3 ligand binding and activation	R-HSA-190239	8.471558e-01	0.072	0	0
Spry regulation of FGF signaling	R-HSA-1295596	8.471558e-01	0.072	0	0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	8.471558e-01	0.072	0	0
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	8.471558e-01	0.072	0	0
DNA Damage Reversal	R-HSA-73942	8.471558e-01	0.072	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	8.487577e-01	0.071	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	8.487577e-01	0.071	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	8.487577e-01	0.071	0	0
Integrin cell surface interactions	R-HSA-216083	8.508759e-01	0.070	0	0
Amino acids regulate mTORC1	R-HSA-9639288	8.516848e-01	0.070	0	0
FLT3 Signaling	R-HSA-9607240	8.523153e-01	0.069	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	8.599022e-01	0.066	0	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	8.599022e-01	0.066	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	8.599022e-01	0.066	0	0
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	8.599022e-01	0.066	0	0
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	8.615516e-01	0.065	0	0
Defective GALNT12 causes CRCS1	R-HSA-5083636	8.615516e-01	0.065	0	0
Defective GALNT3 causes HFTC	R-HSA-5083625	8.615516e-01	0.065	0	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	8.615516e-01	0.065	0	0
Class I peroxisomal membrane protein import	R-HSA-9603798	8.615516e-01	0.065	0	0
Atorvastatin ADME	R-HSA-9754706	8.615516e-01	0.065	0	0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	8.615516e-01	0.065	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	8.615516e-01	0.065	0	0
Prolonged ERK activation events	R-HSA-169893	8.615516e-01	0.065	0	0
Regulation of NF-kappa B signaling	R-HSA-9758274	8.615516e-01	0.065	0	0
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	8.615516e-01	0.065	0	0
Attachment and Entry	R-HSA-9678110	8.615516e-01	0.065	0	0
Virus Assembly and Release	R-HSA-168268	8.615516e-01	0.065	0	0
Intra-Golgi traffic	R-HSA-6811438	8.617272e-01	0.065	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	8.617272e-01	0.065	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	8.702901e-01	0.060	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	8.702901e-01	0.060	0	0
Activation of GABAB receptors	R-HSA-991365	8.706079e-01	0.060	0	0
GABA B receptor activation	R-HSA-977444	8.706079e-01	0.060	0	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	8.745923e-01	0.058	0	0
Phase 2 - plateau phase	R-HSA-5576893	8.745923e-01	0.058	0	0
Vitamin B6 activation to pyridoxal phosphate	R-HSA-964975	8.745923e-01	0.058	0	0
Passive transport by Aquaporins	R-HSA-432047	8.745923e-01	0.058	0	0
Fibronectin matrix formation	R-HSA-1566977	8.745923e-01	0.058	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	8.745923e-01	0.058	0	0
Disorders of Developmental Biology	R-HSA-9675151	8.745923e-01	0.058	0	0
Galactose catabolism	R-HSA-70370	8.745923e-01	0.058	0	0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	8.745923e-01	0.058	0	0
Biosynthesis of maresin-like SPMs	R-HSA-9027307	8.745923e-01	0.058	0	0
Coenzyme A biosynthesis	R-HSA-196783	8.745923e-01	0.058	0	0
Transcriptional regulation of testis differentiation	R-HSA-9690406	8.745923e-01	0.058	0	0
Signaling by FGFR1	R-HSA-5654736	8.758979e-01	0.058	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	8.786671e-01	0.056	0	0
Signaling by FGFR4	R-HSA-5654743	8.789804e-01	0.056	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	8.799649e-01	0.056	0	0
IRS-mediated signalling	R-HSA-112399	8.831718e-01	0.054	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	8.844463e-01	0.053	0	0
RSV-host interactions	R-HSA-9833110	8.850367e-01	0.053	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	8.851993e-01	0.053	0	0
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	8.864053e-01	0.052	0	0
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	8.864053e-01	0.052	0	0
Glycogen storage diseases	R-HSA-3229121	8.864053e-01	0.052	0	0
Regulation of NPAS4 gene expression	R-HSA-9768759	8.864053e-01	0.052	0	0
GDP-fucose biosynthesis	R-HSA-6787639	8.864053e-01	0.052	0	0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	8.864053e-01	0.052	0	0
Choline catabolism	R-HSA-6798163	8.864053e-01	0.052	0	0
Replication of the SARS-CoV-2 genome	R-HSA-9694686	8.864053e-01	0.052	0	0
Surfactant metabolism	R-HSA-5683826	8.868678e-01	0.052	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	8.889688e-01	0.051	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	8.925137e-01	0.049	0	0
Signaling by FGFR3	R-HSA-5654741	8.942923e-01	0.049	0	0
Fanconi Anemia Pathway	R-HSA-6783310	8.942923e-01	0.049	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	8.942923e-01	0.049	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	8.942923e-01	0.049	0	0
Somitogenesis	R-HSA-9824272	8.942923e-01	0.049	0	0
Peroxisomal protein import	R-HSA-9033241	8.966121e-01	0.047	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	8.966121e-01	0.047	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	8.966121e-01	0.047	0	0
PKA activation in glucagon signalling	R-HSA-164378	8.971062e-01	0.047	0	0
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	8.971062e-01	0.047	0	0
Activated point mutants of FGFR2	R-HSA-2033519	8.971062e-01	0.047	0	0
PKA activation	R-HSA-163615	8.971062e-01	0.047	0	0
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	8.971062e-01	0.047	0	0
Gastrulation	R-HSA-9758941	8.971266e-01	0.047	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	8.973423e-01	0.047	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	8.973423e-01	0.047	0	0
Regulation of necroptotic cell death	R-HSA-5675482	8.973423e-01	0.047	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	9.051242e-01	0.043	0	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	9.051242e-01	0.043	0	0
Leishmania phagocytosis	R-HSA-9664417	9.054649e-01	0.043	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.054649e-01	0.043	0	0
Parasite infection	R-HSA-9664407	9.054649e-01	0.043	0	0
Signaling by ERBB4	R-HSA-1236394	9.066137e-01	0.043	0	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	9.067997e-01	0.042	0	0
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	9.067997e-01	0.042	0	0
Pyrimidine biosynthesis	R-HSA-500753	9.067997e-01	0.042	0	0
Translesion Synthesis by POLH	R-HSA-110320	9.067997e-01	0.042	0	0
O2/CO2 exchange in erythrocytes	R-HSA-1480926	9.067997e-01	0.042	0	0
Methionine salvage pathway	R-HSA-1237112	9.067997e-01	0.042	0	0
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	9.067997e-01	0.042	0	0
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	9.067997e-01	0.042	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	9.086723e-01	0.042	0	0
Formation of paraxial mesoderm	R-HSA-9793380	9.086723e-01	0.042	0	0
Signal amplification	R-HSA-392518	9.123516e-01	0.040	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	9.123516e-01	0.040	0	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.123516e-01	0.040	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	9.123516e-01	0.040	0	0
Calnexin/calreticulin cycle	R-HSA-901042	9.123516e-01	0.040	0	0
GPER1 signaling	R-HSA-9634597	9.140069e-01	0.039	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	9.142205e-01	0.039	0	0
Leishmania infection	R-HSA-9658195	9.144100e-01	0.039	0	0
Parasitic Infection Pathways	R-HSA-9824443	9.144100e-01	0.039	0	0
Regulation of PD-L1(CD274) translation	R-HSA-9909620	9.155804e-01	0.038	0	0
Formation of ATP by chemiosmotic coupling	R-HSA-163210	9.155804e-01	0.038	0	0
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.155804e-01	0.038	0	0
Co-inhibition by CTLA4	R-HSA-389513	9.155804e-01	0.038	0	0
Pregnenolone biosynthesis	R-HSA-196108	9.155804e-01	0.038	0	0
Wax and plasmalogen biosynthesis	R-HSA-8848584	9.155804e-01	0.038	0	0
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	9.155804e-01	0.038	0	0
Signaling by NODAL	R-HSA-1181150	9.155804e-01	0.038	0	0
Creatine metabolism	R-HSA-71288	9.155804e-01	0.038	0	0
Common Pathway of Fibrin Clot Formation	R-HSA-140875	9.155804e-01	0.038	0	0
Disorders of transmembrane transporters	R-HSA-5619115	9.165793e-01	0.038	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	9.190600e-01	0.037	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	9.190600e-01	0.037	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	9.190600e-01	0.037	0	0
PPARA activates gene expression	R-HSA-1989781	9.196984e-01	0.036	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.197954e-01	0.036	0	0
SHC-mediated cascade:FGFR3	R-HSA-5654704	9.235344e-01	0.035	0	0
G-protein activation	R-HSA-202040	9.235344e-01	0.035	0	0
FGFR2 ligand binding and activation	R-HSA-190241	9.235344e-01	0.035	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	9.235344e-01	0.035	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	9.235344e-01	0.035	0	0
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.235344e-01	0.035	0	0
IGF1R signaling cascade	R-HSA-2428924	9.244220e-01	0.034	0	0
Insulin receptor signalling cascade	R-HSA-74751	9.244220e-01	0.034	0	0
Ion transport by P-type ATPases	R-HSA-936837	9.244220e-01	0.034	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	9.247512e-01	0.034	0	0
Glycosphingolipid transport	R-HSA-9845576	9.252828e-01	0.034	0	0
Innate Immune System	R-HSA-168249	9.266309e-01	0.033	1	0
PI Metabolism	R-HSA-1483255	9.285912e-01	0.032	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	9.288503e-01	0.032	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	9.291020e-01	0.032	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	9.302889e-01	0.031	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.303168e-01	0.031	0	0
FRS-mediated FGFR3 signaling	R-HSA-5654706	9.307394e-01	0.031	0	0
SHC-mediated cascade:FGFR4	R-HSA-5654719	9.307394e-01	0.031	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	9.307394e-01	0.031	0	0
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	9.307394e-01	0.031	0	0
Molybdenum cofactor biosynthesis	R-HSA-947581	9.307394e-01	0.031	0	0
Serine metabolism	R-HSA-977347	9.307394e-01	0.031	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	9.307394e-01	0.031	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	9.307394e-01	0.031	0	0
Attachment and Entry	R-HSA-9694614	9.307394e-01	0.031	0	0
Assembly Of The HIV Virion	R-HSA-175474	9.307394e-01	0.031	0	0
SLC-mediated transport of organic cations	R-HSA-549127	9.310521e-01	0.031	0	0
Collagen chain trimerization	R-HSA-8948216	9.310521e-01	0.031	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	9.344158e-01	0.029	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	9.350872e-01	0.029	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.363981e-01	0.029	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	9.363981e-01	0.029	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	9.363981e-01	0.029	0	0
FRS-mediated FGFR4 signaling	R-HSA-5654712	9.372658e-01	0.028	0	0
Regulation of IFNA/IFNB signaling	R-HSA-912694	9.372658e-01	0.028	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	9.372658e-01	0.028	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	9.372658e-01	0.028	0	0
RAF-independent MAPK1/3 activation	R-HSA-112409	9.372658e-01	0.028	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	9.376846e-01	0.028	0	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.413491e-01	0.026	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.416118e-01	0.026	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	9.431777e-01	0.025	0	0
Interleukin receptor SHC signaling	R-HSA-912526	9.431777e-01	0.025	0	0
Termination of O-glycan biosynthesis	R-HSA-977068	9.431777e-01	0.025	0	0
Interleukin-20 family signaling	R-HSA-8854691	9.431777e-01	0.025	0	0
Free fatty acids regulate insulin secretion	R-HSA-400451	9.431777e-01	0.025	0	0
Organic anion transport by SLCO transporters	R-HSA-879518	9.431777e-01	0.025	0	0
Carnitine shuttle	R-HSA-200425	9.431777e-01	0.025	0	0
Biosynthesis of maresins	R-HSA-9018682	9.431777e-01	0.025	0	0
Formation of the ureteric bud	R-HSA-9830674	9.431777e-01	0.025	0	0
Collagen formation	R-HSA-1474290	9.432010e-01	0.025	0	0
Glycogen metabolism	R-HSA-8982491	9.459323e-01	0.024	0	0
Tryptophan catabolism	R-HSA-71240	9.459323e-01	0.024	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	9.479562e-01	0.023	0	0
SHC-mediated cascade:FGFR1	R-HSA-5654688	9.485327e-01	0.023	0	0
Thromboxane signalling through TP receptor	R-HSA-428930	9.485327e-01	0.023	0	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	9.485327e-01	0.023	0	0
Plasma lipoprotein assembly	R-HSA-8963898	9.485327e-01	0.023	0	0
Maturation of spike protein	R-HSA-9694548	9.501729e-01	0.022	0	0
Stimuli-sensing channels	R-HSA-2672351	9.509755e-01	0.022	0	0
ECM proteoglycans	R-HSA-3000178	9.520761e-01	0.021	0	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	9.533833e-01	0.021	0	0
Activation of G protein gated Potassium channels	R-HSA-1296041	9.533833e-01	0.021	0	0
G protein gated Potassium channels	R-HSA-1296059	9.533833e-01	0.021	0	0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	9.533833e-01	0.021	0	0
Hyaluronan degradation	R-HSA-2160916	9.533833e-01	0.021	0	0
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.533833e-01	0.021	0	0
Beta-oxidation of pristanoyl-CoA	R-HSA-389887	9.533833e-01	0.021	0	0
Laminin interactions	R-HSA-3000157	9.533833e-01	0.021	0	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	9.533833e-01	0.021	0	0
Scavenging by Class A Receptors	R-HSA-3000480	9.540948e-01	0.020	0	0
TCR signaling	R-HSA-202403	9.560983e-01	0.019	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.571785e-01	0.019	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	9.577204e-01	0.019	0	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.577204e-01	0.019	0	0
MET activates PTK2 signaling	R-HSA-8874081	9.577771e-01	0.019	0	0
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	9.577771e-01	0.019	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.577771e-01	0.019	0	0
Urea cycle	R-HSA-70635	9.577771e-01	0.019	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	9.577771e-01	0.019	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.579129e-01	0.019	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	9.599128e-01	0.018	0	0
Disease	R-HSA-1643685	9.602438e-01	0.018	0	0
SHC-mediated cascade:FGFR2	R-HSA-5654699	9.617570e-01	0.017	0	0
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.617570e-01	0.017	0	0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.617570e-01	0.017	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	9.617570e-01	0.017	0	0
Formation of the cornified envelope	R-HSA-6809371	9.620053e-01	0.017	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.633512e-01	0.016	0	0
GABA receptor activation	R-HSA-977443	9.636735e-01	0.016	0	0
Metabolism of polyamines	R-HSA-351202	9.636735e-01	0.016	0	0
FRS-mediated FGFR2 signaling	R-HSA-5654700	9.653619e-01	0.015	0	0
Pyrimidine salvage	R-HSA-73614	9.653619e-01	0.015	0	0
Prednisone ADME	R-HSA-9757110	9.653619e-01	0.015	0	0
Aquaporin-mediated transport	R-HSA-445717	9.662672e-01	0.015	0	0
Collagen degradation	R-HSA-1442490	9.662672e-01	0.015	0	0
Translation of Structural Proteins	R-HSA-9694635	9.680145e-01	0.014	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	9.686272e-01	0.014	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	9.686272e-01	0.014	0	0
Glucagon-type ligand receptors	R-HSA-420092	9.686272e-01	0.014	0	0
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.686272e-01	0.014	0	0
ABC transporter disorders	R-HSA-5619084	9.701328e-01	0.013	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	9.715849e-01	0.013	0	0
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.715849e-01	0.013	0	0
Neurotransmitter clearance	R-HSA-112311	9.715849e-01	0.013	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.715849e-01	0.013	0	0
G alpha (q) signalling events	R-HSA-416476	9.717615e-01	0.012	1	0
Synthesis of PC	R-HSA-1483191	9.720931e-01	0.012	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.725312e-01	0.012	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.742639e-01	0.011	0	0
Aspartate and asparagine metabolism	R-HSA-8963693	9.742639e-01	0.011	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	9.742639e-01	0.011	0	0
Cellular response to hypoxia	R-HSA-1234174	9.749937e-01	0.011	0	0
Platelet homeostasis	R-HSA-418346	9.752268e-01	0.011	0	0
Inwardly rectifying K+ channels	R-HSA-1296065	9.766905e-01	0.010	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.768136e-01	0.010	0	0
Cardiac conduction	R-HSA-5576891	9.768394e-01	0.010	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.781080e-01	0.010	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	9.788884e-01	0.009	0	0
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.788884e-01	0.009	0	0
Neddylation	R-HSA-8951664	9.791051e-01	0.009	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.791951e-01	0.009	0	0
Acyl chain remodelling of PC	R-HSA-1482788	9.808791e-01	0.008	0	0
Resolution of D-Loop Structures	R-HSA-5693537	9.808791e-01	0.008	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.808791e-01	0.008	0	0
eNOS activation	R-HSA-203615	9.826823e-01	0.008	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	9.826823e-01	0.008	0	0
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.826823e-01	0.008	0	0
Hyaluronan metabolism	R-HSA-2142845	9.826823e-01	0.008	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	9.826823e-01	0.008	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.829079e-01	0.007	0	0
Acyl chain remodelling of PE	R-HSA-1482839	9.843155e-01	0.007	0	0
Transferrin endocytosis and recycling	R-HSA-917977	9.843155e-01	0.007	0	0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	R-HSA-193775	9.843155e-01	0.007	0	0
ABC-family proteins mediated transport	R-HSA-382556	9.848044e-01	0.007	0	0
GPVI-mediated activation cascade	R-HSA-114604	9.857948e-01	0.006	0	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.857948e-01	0.006	0	0
Triglyceride catabolism	R-HSA-163560	9.857948e-01	0.006	0	0
Voltage gated Potassium channels	R-HSA-1296072	9.871346e-01	0.006	0	0
Ubiquinol biosynthesis	R-HSA-2142789	9.871346e-01	0.006	0	0
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.871346e-01	0.006	0	0
Metabolism of folate and pterines	R-HSA-196757	9.871346e-01	0.006	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.875915e-01	0.005	0	0
Synthesis of PA	R-HSA-1483166	9.880513e-01	0.005	0	0
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.883481e-01	0.005	0	0
Citric acid cycle (TCA cycle)	R-HSA-71403	9.883913e-01	0.005	0	0
Diseases associated with N-glycosylation of proteins	R-HSA-3781860	9.894473e-01	0.005	0	0
RAS processing	R-HSA-9648002	9.894473e-01	0.005	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.900718e-01	0.004	0	0
Signaling by Insulin receptor	R-HSA-74752	9.903966e-01	0.004	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.903966e-01	0.004	0	0
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.904428e-01	0.004	0	0
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.904428e-01	0.004	0	0
tRNA Aminoacylation	R-HSA-379724	9.907711e-01	0.004	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.907711e-01	0.004	0	0
Signaling by Retinoic Acid	R-HSA-5362517	9.907711e-01	0.004	0	0
Interleukin-10 signaling	R-HSA-6783783	9.908216e-01	0.004	0	0
SLC-mediated transport of organic anions	R-HSA-9955298	9.908216e-01	0.004	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.910732e-01	0.004	0	0
Aflatoxin activation and detoxification	R-HSA-5423646	9.913444e-01	0.004	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.921611e-01	0.003	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	9.921611e-01	0.003	0	0
Heme biosynthesis	R-HSA-189451	9.921611e-01	0.003	0	0
Translation of Structural Proteins	R-HSA-9683701	9.921611e-01	0.003	0	0
Ion channel transport	R-HSA-983712	9.922822e-01	0.003	0	0
Synthesis of very long-chain fatty acyl-CoAs	R-HSA-75876	9.935706e-01	0.003	0	0
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.941773e-01	0.003	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.946805e-01	0.002	0	0
Metabolism of nucleotides	R-HSA-15869	9.947194e-01	0.002	0	0
Degradation of cysteine and homocysteine	R-HSA-1614558	9.947268e-01	0.002	0	0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.949777e-01	0.002	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.951501e-01	0.002	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.952244e-01	0.002	0	0
Diseases of DNA repair	R-HSA-9675135	9.952244e-01	0.002	0	0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.956752e-01	0.002	0	0
Metal ion SLC transporters	R-HSA-425410	9.960834e-01	0.002	0	0
Plasma lipoprotein remodeling	R-HSA-8963899	9.960834e-01	0.002	0	0
Interferon gamma signaling	R-HSA-877300	9.961392e-01	0.002	0	0
Peptide hormone metabolism	R-HSA-2980736	9.962045e-01	0.002	0	0
Chemokine receptors bind chemokines	R-HSA-380108	9.964531e-01	0.002	0	0
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.964531e-01	0.002	0	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.964642e-01	0.002	0	0
Metabolism of cofactors	R-HSA-8978934	9.964642e-01	0.002	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.964879e-01	0.002	0	0
Neurotransmitter release cycle	R-HSA-112310	9.967526e-01	0.001	0	0
Class B/2 (Secretin family receptors)	R-HSA-373080	9.967526e-01	0.001	0	0
Downstream TCR signaling	R-HSA-202424	9.967526e-01	0.001	0	0
Branched-chain amino acid catabolism	R-HSA-70895	9.970911e-01	0.001	0	0
Complex IV assembly	R-HSA-9864848	9.970911e-01	0.001	0	0
The phototransduction cascade	R-HSA-2514856	9.970911e-01	0.001	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	9.973658e-01	0.001	0	0
Iron uptake and transport	R-HSA-917937	9.975159e-01	0.001	0	0
Glucuronidation	R-HSA-156588	9.978397e-01	0.001	0	0
Bile acid and bile salt metabolism	R-HSA-194068	9.978593e-01	0.001	0	0
FCERI mediated MAPK activation	R-HSA-2871796	9.981653e-01	0.001	0	0
Dectin-2 family	R-HSA-5621480	9.983957e-01	0.001	0	0
Triglyceride metabolism	R-HSA-8979227	9.986845e-01	0.001	0	0
Regulation of beta-cell development	R-HSA-186712	9.986845e-01	0.001	0	0
Endogenous sterols	R-HSA-211976	9.989212e-01	0.000	0	0
Nucleotide salvage	R-HSA-8956321	9.989212e-01	0.000	0	0
Respiratory electron transport	R-HSA-611105	9.989415e-01	0.000	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	9.989506e-01	0.000	0	0
Complex I biogenesis	R-HSA-6799198	9.991154e-01	0.000	0	0
Sulfur amino acid metabolism	R-HSA-1614635	9.991482e-01	0.000	0	0
Xenobiotics	R-HSA-211981	9.991990e-01	0.000	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.992234e-01	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.992352e-01	0.000	0	0
Metabolism of steroid hormones	R-HSA-196071	9.994053e-01	0.000	0	0
Kidney development	R-HSA-9830369	9.994053e-01	0.000	0	0
O-linked glycosylation of mucins	R-HSA-913709	9.994615e-01	0.000	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.994976e-01	0.000	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.994976e-01	0.000	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.995178e-01	0.000	0	0
Metabolism of porphyrins	R-HSA-189445	9.996002e-01	0.000	0	0
Diseases of carbohydrate metabolism	R-HSA-5663084	9.996722e-01	0.000	0	0
Aspirin ADME	R-HSA-9749641	9.996722e-01	0.000	0	0
Potassium Channels	R-HSA-1296071	9.997120e-01	0.000	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.997332e-01	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.997603e-01	0.000	0	0
Cholesterol biosynthesis	R-HSA-191273	9.998005e-01	0.000	0	0
Phospholipid metabolism	R-HSA-1483257	9.998126e-01	0.000	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.998194e-01	0.000	0	0
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.998194e-01	0.000	0	0
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.998519e-01	0.000	0	0
Keratinization	R-HSA-6805567	9.998550e-01	0.000	0	0
Peroxisomal lipid metabolism	R-HSA-390918	9.998901e-01	0.000	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	9.999122e-01	0.000	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999427e-01	0.000	0	0
FCGR activation	R-HSA-2029481	9.999632e-01	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	9.999873e-01	0.000	0	0
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999899e-01	0.000	0	0
G alpha (s) signalling events	R-HSA-418555	9.999916e-01	0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	9.999916e-01	0.000	0	0
Antimicrobial peptides	R-HSA-6803157	9.999950e-01	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	9.999972e-01	0.000	0	0
G alpha (i) signalling events	R-HSA-418594	9.999973e-01	0.000	0	0
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999988e-01	0.000	0	0
Metabolism of steroids	R-HSA-8957322	9.999989e-01	0.000	0	0
Regulation of Complement cascade	R-HSA-977606	9.999990e-01	0.000	0	0
Drug ADME	R-HSA-9748784	9.999992e-01	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	9.999993e-01	0.000	0	0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.999995e-01	0.000	0	0
Sensory perception of taste	R-HSA-9717189	9.999995e-01	0.000	0	0
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999995e-01	0.000	0	0
O-linked glycosylation	R-HSA-5173105	9.999998e-01	0.000	0	0
Cytochrome P450 - arranged by substrate type	R-HSA-211897	9.999998e-01	0.000	0	0
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	9.999999e-01	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	9.999999e-01	0.000	0	0
Complement cascade	R-HSA-166658	9.999999e-01	0.000	0	0
GPCR downstream signalling	R-HSA-388396	9.999999e-01	0.000	1	0
Visual phototransduction	R-HSA-2187338	9.999999e-01	0.000	0	0
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	1.000000e+00	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	1.000000e+00	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000	0	0
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000	1	0
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000	0	0
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000	0	0
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0