DYRK4

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A0A2R8Y4L2	S6	Sugiyama	HNRNPA1L3 HNRNPA1P48	_______________MSKSEsPKEPEQLRKLFIGGLsFEtT
A5A3E0	S1068	Sugiyama	POTEF A26C1B	SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
O00115	S70	Sugiyama	DNASE2 DNASE2A DNL2	QYKyLDEssGGWRDGRALINsPEGAVGRSLQPLyRSNTSQL
O00178	S12	Sugiyama	GTPBP1	_________MATERsRsAMDsPVPAsMFAPEPssPGAARAA
O00178	S6	Sugiyama	GTPBP1	_______________MATERsRsAMDsPVPAsMFAPEPssP
O00178	S8	Sugiyama	GTPBP1	_____________MATERsRsAMDsPVPAsMFAPEPssPGA
O00193	S17	Sugiyama	SMAP C11orf58	____MsAARESHPHGVKRsAsPDDDLGssNWEAADLGNEER
O00429	S126	Sugiyama	DNM1L DLP1 DRP1	EIRQEIENETERISGNNKGVsPEPIHLKIFSPNVVNLTLVD
O00468	S738	Sugiyama	AGRN AGRIN	CGSDGVTYSTECELKKARCEsQRGLYVAAQGACRGPTFAPL
O00499	S298	Sugiyama	BIN1 AMPHL	TFtVKAQPsDNAPAKGNKsPsPPDGsPAAtPEIRVNHEPEP
O00499	T307	Sugiyama	BIN1 AMPHL	DNAPAKGNKsPsPPDGsPAAtPEIRVNHEPEPAGGAtPGAt
O00562	S326	Sugiyama	PITPNM1 DRES9 NIR2 PITPNM	GKQWSSSSRssYsSQHGGAVsPQSLsEWRMQNIARDSENSS
O14556	T301	Sugiyama	GAPDHS GAPD2 GAPDH2 GAPDS HSD-35 HSD35	ASTGAAKAVTKVIPELKGKLtGMAFRVPTPDVSVVDLTCRL
O14639	S431	Sugiyama	ABLIM1 ABLIM KIAA0059 LIMAB1	TSGYDDKQERQsLGEsPRtLsPtPsAEGyQDVRDRMIHRst
O15031	S650	Sugiyama	PLXNB2 KIAA0315	CVSNRWTCQWDLRYHECREAsPNPEDGIVRAHMEDSCPQFL
O15037	S291	Sugiyama	KHNYN KIAA0323	GWKELPGEEAWEREVALRPQsVGGGAREsAPLKGKALGKEE
O15047	S470	Sugiyama	SETD1A KIAA0339 KMT2F SET1 SET1A	sPEREEVRtsPRPAsPARsGsPAPEttNESVPFAQHSSLDS
O15160	S258	Sugiyama	POLR1C POLR1E	DITLLEPVEGEAAEELSRCFsPGVIEVQEVQGKKVARVANP
O15460	S531	Sugiyama	P4HA2 UNQ290/PRO330	KWVSNKWFHERGQEFLRPCGstEVD________________
O43852	Y106	Sugiyama	CALU	GFVtVDELKDWIKFAQKRWIyEDVERQWKGHDLNEDGLVsW
O60271	S1188	Sugiyama	SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6	ISIPLTETNKTSGVPGNRPGsVIRVYGDENSDKVTPGTFIP
O60271	S194	Sugiyama	SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6	LERTKLHQLsGsDQLEstAHsRIRKERPIsLGIFPLPAGDG
O60716	S252	Sugiyama	CTNND1 KIAA0384	sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
O60927	T75	Sugiyama	PPP1R11 HCGV TCTE5	RRssKCCCIyEKPRAFGEsstEsDEEEEEGCGHtHCVRGHR
O75122	S21	Sugiyama	CLASP2 KIAA0627	MAMGDDKsFDDEEsVDGNRPssAAsAFKVPAPKTSGNPANS
O75131	S242	Sugiyama	CPNE3 CPN3 KIAA0636	SHDLIGTFQTTMTKLKEAsRssPVEFECINEKKRQKKKSYK
O75179	S2401	Sugiyama	ANKRD17 GTAR KIAA0697	CSSASNDSSAQSVSSGVRAPsPAPssVPLGSEKPSNVSQDR
O75376	S157	Sugiyama	NCOR1 KIAA1047	LRASADAKKDPAFGGKHEAPssPIsGQPCGDDQNAsPsKLS
O75792	S18	Sugiyama	RNASEH2A RNASEHI RNHIA	___MDLSELERDNTGRCRLssPVPAVCRKEPCVLGVDEAGR
O94776	S435	Sugiyama	MTA2 MTA1L1 PID	RGtTEPHSRGHLsRPEAQsLsPyttsANRAKLLAKNRQtFL
O94808	S202	Sugiyama	GFPT2	FALVFKSVHYPGEAVATRRGsPLLIGVRSKYKLSTEQIPIL
O94826	S91	Sugiyama	TOMM70 KIAA0719 TOM70 TOMM70A	RGDASGLKRNSERKtPEGRAsPAPGsGHPEGPGAHLDMNsL
O94842	S178	Sugiyama	TOX4 C14orf92 KIAA0737	GGGTILPPAQSPEDRLsttPsPtssLHEDGVEDFRRQLPSQ
O94842	T176	Sugiyama	TOX4 C14orf92 KIAA0737	SLGGGTILPPAQSPEDRLsttPsPtssLHEDGVEDFRRQLP
O95071	S1308	Sugiyama	UBR5 EDD EDD1 HYD KIAA0896	VEHCQYRPPRIREDRNRKtAsPEDsDMPDHDLEPPRFAQLA
O95149	S350	Sugiyama	SNUPN RNUT1 SPN1	ENGHyELEHLstPKLKGssHsPDHPGCLMEN__________
O95503	S280	Sugiyama	CBX6	LLAAPAAPYDARssGssGCPsPtPQSSDPDDTPPKLLPETV
O95503	T282	Sugiyama	CBX6	AAPAAPYDARssGssGCPsPtPQSSDPDDTPPKLLPETVsP
O95816	S208	Sugiyama	BAG2	IKLLEHSKGAGSKTLQQNAEsRFN_________________
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04406	T229	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	AstGAAKAVGKVIPELNGKLtGMAFRVPtANVsVVDLtCRL
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05023	S519	Sugiyama	ATP1A1	sEPQHLLVMKGAPERILDRCssILLHGKEQPLDEELKDAFQ
P05187	S177	Sugiyama	ALPP PLAP	RAKKAGKSVGVVTTTRVQHAsPAGtyAHtVNRNWysDADVP
P05386	S101	Sugiyama	RPLP1 RRP1	APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386	S104	Sugiyama	RPLP1 RRP1	tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387	S102	Sugiyama	RPLP2 D11S2243E RPP2	PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387	S105	Sugiyama	RPLP2 D11S2243E RPP2	GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P06733	S272	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	FRsGKyDLDFKsPDDPsRyIsPDQLADLyKsFIKDyPVVsI
P06744	S455	Sugiyama	GPI	ALMRGKSTEEARKELQAAGKsPEDLERLLPHKVFEGNRPTN
P06744	T109	Sugiyama	GPI	KINyTEGRAVLHVALRNRsNtPILVDGKDVMPEVNKVLDKM
P07195	S303	Sugiyama	LDHB	GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07858	S216	Sugiyama	CTSB CPSB	PPCTGEGDTPKCSKICEPGysPtyKQDKHYGYNSYSVSNSE
P07900	S52	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900	T65	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	LRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPNKQ
P07942	T1141	Sugiyama	LAMB1	FWGDPDVECRACDCDPRGIEtPQCDQSTGQCVCVEGVEGPR
P08195	S598	Sugiyama	SLC3A2 MDU1	LQASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEP
P08195	S607	Sugiyama	SLC3A2 MDU1	ASLPAKADLLLstQPGREEGsPLELERLKLEPHEGLLLRFP
P08238	T60	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	LRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPNPQ
P08651	S339	Sugiyama	NFIC NFI	GGIssPVKKtEMDKsPFNsPsPQDsPRLSsFTQHHRPVIAV
P08708	S89	Sugiyama	RPS17 RPS17L	ISIKLQEEERERRDNyVPEVsALDQEIIEVDPDtKEMLKLL
P09651	S6	Sugiyama	HNRNPA1 HNRPA1	_______________MsKsEsPKEPEQLRKLFIGGLsFEtT
P09923	S174	Sugiyama	ALPI	RAKQAGKSVGVVTTTRVQHAsPAGtyAHtVNRNWysDADMP
P0CG38	S1068	Sugiyama	POTEI	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39	S1031	Sugiyama	POTEJ	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P10809	S225	Sugiyama	HSPD1 HSP60	KtLNDELEIIEGMKFDRGyIsPyFINtsKGQKCEFQDAyVL
P11142	T38	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P12277	S163	Sugiyama	CKB CKBB	PPHCsRGERRAIEKLAVEALssLDGDLAGRyyALKsMtEAE
P13639	S23	Sugiyama	EEF2 EF2	NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639	S595	Sugiyama	EEF2 EF2	PVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGLAE
P13667	S126	Sugiyama	PDIA4 ERP70 ERP72	NILKDKDPPIPVAKIDAtsAsVLAsRFDVsGyPtIKILKKG
P13797	S339	Sugiyama	PLS3	PRIDINMsGFNETDDLKRAEsMLQQADKLGCRQFVTPADVV
P13804	S192	Sugiyama	ETFA	sFDAAATsGGsASsEKAsStsPVEIsEWLDQKLTKSDRPEL
P13861	S99	Sugiyama	PRKAR2A PKR2 PRKAR2	EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314	S442	Sugiyama	PRKCSH G19P1	EYVYRLCPFKLVSQKPKLGGsPtsLGtWGsWIGPDHDKFSA
P14314	T444	Sugiyama	PRKCSH G19P1	VYRLCPFKLVSQKPKLGGsPtsLGtWGsWIGPDHDKFSAMK
P14866	S101	Sugiyama	HNRNPL HNRPL P/OKcl.14	GAAGGGGGGENyDDPHKtPAsPVVHIRGLIDGVVEADLVEA
P15531	S122	Sugiyama	NME1 NDPKA NM23	GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P15880	S190	Sugiyama	RPS2 RPS4	WGNKIGKPHTVPCKVTGRCGsVLVRLIPAPRGtGIVsAPVP
P17066	T40	Sugiyama	HSPA6 HSP70B'	VGVFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQ
P17812	S575	Sugiyama	CTPS1 CTPS	LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P17844	S519	Sugiyama	DDX5 G17P1 HELR HLR1	AGKRGGFNTFRDRENYDRGYssLLKRDFGAKTQNGVYSAAN
P17980	S376	Sugiyama	PSMC3 TBP1	MPNEEARARIMQIHSRKMNVsPDVNyEELARCTDDFNGAQC
P18754	S11	Sugiyama	RCC1 CHC1	__________MsPKRIAKRRsPPADAIPKsKKVKVsHRsHs
P18827	S233	Sugiyama	SDC1 SDC	FETSGENTAVVAVEPDRRNQsPVDQGAtGAsQGLLDRKEVL
P21333	S2152	Sugiyama	FLNA FLN FLN1	VKVTGEGRVKEsITRRRRAPsVANVGsHCDLsLKIPEIsIQ
P22059	S193	Sugiyama	OSBP OSBP1	VTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNTLRT
P22626	S189	Sugiyama	HNRNPA2B1 HNRPA2B1	IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P22626	Y353	Sugiyama	HNRNPA2B1 HNRPA2B1	GGNyGPGGsGGsGGyGGRsRy____________________
P23381	T383	Sugiyama	WARS1 IFI53 WARS WRS	DtAKQIKTKVNKHAFsGGRDtIEEHRQFGGNCDVDVSFMYL
P23588	S311	Sugiyama	EIF4B	YRGGGDRYEDRYDRRDDRsWssRDDysRDDYRRDDRGPPQR
P25054	S2022	Sugiyama	APC DP2.5	PQASGYAPKSFHVEDTPVCFsRNSSLSSLSIDsEDDLLQEC
P25398	Y127	Sugiyama	RPS12	sCVVVKDYGKESQAKDVIEEyFKCKK_______________
P25786	S14	Sugiyama	PSMA1 HC2 NU PROS30 PSC2	_______MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQGSA
P26232	T657	Sugiyama	CTNNA2 CAPR	EDDsDFEQEDYDVRsRtsVQtEDDQLIAGQsARAIMAQLPQ
P27708	S1038	Sugiyama	CAD	QLPNNMAMALHRQQCRVLGtsPEAIDSAENRFKFSRLLDTI
P27824	S362	Sugiyama	CANX	WDEDMDGEWEAPQIANPRCEsAPGCGVWQRPVIDNPNyKGK
P28066	S16	Sugiyama	PSMA5	_____MFLTRsEyDRGVNtFsPEGRLFQVEyAIEAIKLGST
P28066	S179	Sugiyama	PSMA5	sGtFVQCDARAIGsAsEGAQssLQEVyHKSMTLKEAIKSSL
P28799	T182	Sugiyama	GRN	VHCCPHGAFCDLVHTRCItPtGTHPLAKKLPAQRTNRAVAL
P29692	S133	Sugiyama	EEF1D EF1D	NVLEKssPGHRAtAPQtQHVsPMRQVEPPAKKPAtPAEDDE
P29692	T147	Sugiyama	EEF1D EF1D	PQtQHVsPMRQVEPPAKKPAtPAEDDEDDDIDLFGsDNEEE
P31943	S104	Sugiyama	HNRNPH1 HNRPH HNRPH1	EVFKSNNVEMDWVLKHtGPNsPDtANDGFVRLRGLPFGCSK
P33176	S175	Sugiyama	KIF5B KNS KNS1	VHEDKNRVPYVKGCTERFVCsPDEVMDtIDEGKSNRHVAVT
P33316	S88	Sugiyama	DUT	RGASTVGAAGWKGELPKAGGsPAPGPEtPAIsPsKRARPAE
P33992	S315	Sugiyama	MCM5 CDC46	RVLGIQVDTDGSGRSFAGAVsPQEEEEFRRLAALPNVYEVI
P34896	T405	Sugiyama	SHMT1	NKNTCPGDRSALRPSGLRLGtPALTSRGLLEKDFQKVAHFI
P34931	T40	Sugiyama	HSPA1L	VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P35221	S641	Sugiyama	CTNNA1	GIRDIRKAVLMIRtPEELDDsDFEtEDFDVRsRtsVQtEDD
P35221	T658	Sugiyama	CTNNA1	LDDsDFEtEDFDVRsRtsVQtEDDQLIAGQsARAIMAQLPQ
P35269	T389	Sugiyama	GTF2F1 RAP74	PPKRERKPsGGSSRGNsRPGtPsAEGGstsstLRAAASKLE
P35606	S859	Sugiyama	COPB2	GKDFQPSRstAQQELDGKPAsPtPVIVAsHtANKEEKSLLE
P35606	T861	Sugiyama	COPB2	DFQPSRstAQQELDGKPAsPtPVIVAsHtANKEEKSLLELE
P35613	S278	Sugiyama	BSG UNQ6505/PRO21383	ITDSEDKALMNGSESRFFVsssQGRSELHIENLNMEADPGQ
P35998	T193	Sugiyama	PSMC2 MSS1	TYSDVGGCKEQIEKLREVVEtPLLHPERFVNLGIEPPKGVL
P36578	S295	Sugiyama	RPL4 RPL1	sNyNLPMHKMINtDLsRILKsPEIQRALRAPRKKIHRRVLK
P37802	S185	Sugiyama	TAGLN2 KIAA0120 CDABP0035	NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P38646	S89	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646	T87	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKR
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40818	S719	Sugiyama	USP8 KIAA0055 UBPY	KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P41091	S107	Sugiyama	EIF2S3 EIF2G	KIYKLDDPSCPRPECyRSCGsstPDEFPtDIPGtKGNFKLV
P41091	T109	Sugiyama	EIF2S3 EIF2G	YKLDDPSCPRPECyRSCGsstPDEFPtDIPGtKGNFKLVRH
P41252	S1047	Sugiyama	IARS1 IARS	ESHTEFIFTTIKAPLKPYPVsPsDKVLIQEKTQLKGSELEI
P42166	T160	Sugiyama	TMPO LAP2	KLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsNDs
P42167	T160	Sugiyama	TMPO LAP2	KLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSNDS
P42677	S11	Sugiyama	RPS27 MPS1	__________MPLAKDLLHPsPEEEKRKHKKKRLVQsPNsy
P42765	T227	Sugiyama	ACAA2	EVKTKKGKQTMQVDEHARPQtTLEQLQKLPPVFKKDGTVTA
P42898	T34	Sugiyama	MTHFR	CLEGSASSGSESSKDSSRCStPGLDPERHERLREKMRRRLE
P43243	S188	Sugiyama	MATR3 KIAA0723	EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P46013	S2105	Sugiyama	MKI67	tPDHTEESttDDKTTKIACKsPPPEsMDtPTstRRRPKtPL
P46777	S230	Sugiyama	RPL5 MSTP030	yLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAHAAIREN
P46777	T232	Sugiyama	RPL5 MSTP030	MEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAHAAIRENPV
P47712	S727	Sugiyama	PLA2G4A CPLA2 PLA2G4	VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P48741	T40	Sugiyama	HSPA7 HSP70B	VGVFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQ
P49023	S303	Sugiyama	PXN	QRADGERCWAAGWPRDGGRssPGGQDEGGFMAQGKtGsssP
P49327	S974	Sugiyama	FASN FAS	VSGKVyQWDDPDPRLFDHPEsPtPNPTEPLFLAQAEVYKEL
P49327	T2204	Sugiyama	FASN FAS	LRKLQELSSKADEAsELACPtPKEDGLAQQQtQLNLRSLLV
P49757	S634	Sugiyama	NUMB C14orf41	DPFEAQWAALENKSKQRtNPsPtNPFSSDLQKTFEIEL___
P50748	S1034	Sugiyama	KNTC1 KIAA0166 ROD	DLREQHIKAHEVAQAKHKPGstPEPIAAEVRsPsMEsKLHR
P51812	S715	Sugiyama	RPS6KA3 ISPK1 MAPKAPK1B RSK2	APHLVKGAMAAtysALNRNQsPVLEPVGRsTLAQRRGIKKI
P51991	S356	Sugiyama	HNRNPA3 HNRPA3	SGQQQSNYGPMKGGsFGGRssGsPyGGGyGsGGGsGGyGsR
P51991	S358	Sugiyama	HNRNPA3 HNRPA3	QQQSNYGPMKGGsFGGRssGsPyGGGyGsGGGsGGyGsRRF
P51991	Y360	Sugiyama	HNRNPA3 HNRPA3	QSNYGPMKGGsFGGRssGsPyGGGyGsGGGsGGyGsRRF__
P52907	S123	Sugiyama	CAPZA1	KEAsDPQPEEADGGLKsWREsCDsALRAYVKDHYSNGFCTV
P53365	S260	Sugiyama	ARFIP2 POR1	TDLEELsLGPRDAGTRGRLEsAQATFQAHRDKYEKLRGDVA
P53396	S457	Sugiyama	ACLY	FLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMPQD
P53992	S328	Sugiyama	SEC24C KIAA0079	sQPGPPQPLPPKRLDPDAIPsPIQVIEDDRNNRGTEPFVTG
P54652	T39	Sugiyama	HSPA2	VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P55036	S358	Sugiyama	PSMD4 MCB1	VLENLPGVDPNNEAIRNAMGsLAsQATKDGKKDKKEEDKK_
P55072	S718	Sugiyama	VCP HEL-220 HEL-S-70	AIREsIEsEIRRERERQtNPsAMEVEEDDPVPEIRRDHFEE
P55081	T267	Sugiyama	MFAP1	ETKKELEENKRsLAALDALNtDDENDEEEyEAWKVRELKRI
P55209	T62	Sugiyama	NAP1L1 NRP	MMQNPQILAALQERLDGLVEtPtGyIEsLPRVVKRRVNALK
P55795	S104	Sugiyama	HNRNPH2 FTP3 HNRPH2	EVFKSNsVEMDWVLKHtGPNsPDtANDGFVRLRGLPFGCSK
P60174	S212	Sugiyama	TPI1 TPI	WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709	S199	Sugiyama	ACTB	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709	S323	Sugiyama	ACTB	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709	S368	Sugiyama	ACTB	sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60866	T6	Sugiyama	RPS20	_______________MAFKDtGKtPVEPEVAIHRIRITLTS
P61254	S32	Sugiyama	RPL26	sKNRKRHFNAPsHIRRKIMssPLSKELRQKYNVRSMPIRKD
P61313	S100	Sugiyama	RPL15 EC45 TCBAP0781	tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61916	S40	Sugiyama	NPC2 HE1	EPVQFKDCGsVDGVIKEVNVsPCPtQPCQLSKGQSYSVNVT
P61978	S75	Sugiyama	HNRNPK HNRPK	GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P62263	T133	Sugiyama	RPS14 PRO2640	QsALRALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL__
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62736	S325	Sugiyama	ACTA2 ACTSA ACTVS GIG46	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62750	S43	Sugiyama	RPL23A	KAKKAVLKGVHSHKKKKIRtsPTFRRPKTLRLRRQPKYPRK
P62750	T42	Sugiyama	RPL23A	LKAKKAVLKGVHSHKKKKIRtsPTFRRPKTLRLRRQPKYPR
P62917	S14	Sugiyama	RPL8	_______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P62979	S123	Sugiyama	RPS27A UBA80 UBCEP1	LKYYKVDENGKIsRLRRECPsDECGAGVFMAsHFDRHyCGK
P62995	T201	Sugiyama	TRA2B SFRS10	GMELDGRRIRVDFSITKRPHtPtPGIyMGRPtYGssRRRDY
P63104	S28	Sugiyama	YWHAZ	QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63261	S199	Sugiyama	ACTG1 ACTG	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261	S323	Sugiyama	ACTG1 ACTG	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261	S368	Sugiyama	ACTG1 ACTG	sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63267	S324	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P67809	S209	Sugiyama	YBX1 NSEP1 YB1	RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P67809	Y208	Sugiyama	YBX1 NSEP1 YB1	yRRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGE
P68032	S325	Sugiyama	ACTC1 ACTC	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133	S325	Sugiyama	ACTA1 ACTA	TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68431	T46	Sugiyama	H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J	ARKsAPATGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
P78347	S210	Sugiyama	GTF2I BAP135 WBSCR6	EPKKHVGGRVMVtDADRsILsPGGsCGPIKVKTEPTEDSGI
P78371	S144	Sugiyama	CCT2 99D8.1 CCTB	QTIIAGWREATKAAREALLssAVDHGsDEVKFRQDLMNIAG
P83731	S38	Sugiyama	RPL24	GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P84098	S13	Sugiyama	RPL19	________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEIA
P84098	S37	Sugiyama	RPL19	CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
P84243	T46	Sugiyama	H3-3A H3.3A H3F3 H3F3A PP781; H3-3B H3.3B H3F3B	ARKsAPsTGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
Q00059	S160	Sugiyama	TFAM TCF6 TCF6L2	RKAMTKKKELTLLGKPKRPRsAYNVyVAERFQEAKGDsPQE
Q00613	S363	Sugiyama	HSF1 HSTF1	AsVTALtDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNE
Q00613	T367	Sugiyama	HSF1 HSTF1	ALtDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNELSDH
Q01082	S2197	Sugiyama	SPTBN1 SPTB2	KTALPAQsAAtLPARtQEtPsAQMEGFLNRKHEWEAHNKKA
Q01082	T2192	Sugiyama	SPTBN1 SPTB2	sDRKAKTALPAQsAAtLPARtQEtPsAQMEGFLNRKHEWEA
Q01082	T2195	Sugiyama	SPTBN1 SPTB2	KAKTALPAQsAAtLPARtQEtPsAQMEGFLNRKHEWEAHNK
Q01650	S31	Sugiyama	SLC7A5 CD98LC LAT1 MPE16	LAAPAAEEKEEAREKMLAAKsADGsAPAGEGEGVtLQRNIT
Q01844	S274	Sugiyama	EWSR1 EWS	YSQQSSSYGQQSsFRQDHPssMGVyGQESGGFSGPGENRSM
Q02543	T24	Sugiyama	RPL18A	SGTLREYKVVGRCLPTPKCHtPPLYRMRIFAPNHVVAKSRF
Q06210	S205	Sugiyama	GFPT1 GFAT GFPT	FALVFKSVHFPGQAVGTRRGsPLLIGVRSEHKLSTDHIPIL
Q07157	S912	Sugiyama	TJP1 ZO1	NQtyPPYsPQAQPQPIHRIDsPGFKPAsQQKAEAssPVPyL
Q07866	S460	Sugiyama	KLC1 KLC KNS2	QKDGTsFGEyGGWyKACKVDsPtVTTtLKNLGALyRRQGKF
Q07960	S51	Sugiyama	ARHGAP1 CDC42GAP RHOGAP1	KNWPsDEMPDFPKsDDsKsssPELVtHLKWDDPyyDIARHQ
Q08AD1	S1321	Sugiyama	CAMSAP2 CAMSAP1L1 KIAA1078	sVHsGKRtPRsEsVEGFLsPsRCGsRNGEKDWENAsttssV
Q08AD1	S673	Sugiyama	CAMSAP2 CAMSAP1L1 KIAA1078	DASKFLQDyDIRTGNTREALsPCPsTVsTKSQPGSSAssss
Q08J23	S456	Sugiyama	NSUN2 SAKI TRM4	NKRQPKLQGKSAEtREstQLsPADLTEGKPTDPSKLEsPsF
Q09666	S230	Sugiyama	AHNAK PM227	sGsGAAsPtGsAVDIRAGAIsAsGPELQGAGHsKLQVTMPG
Q09666	S93	Sugiyama	AHNAK PM227	LLNTMGHHTVGLKLHRKGDRsPEPGQtWtREVFssCssEVV
Q12792	S143	Sugiyama	TWF1 PTK9	GTVKEDVSLHGYKKyLLsQssPAPLtAAEEELRQIKINEVQ
Q13098	S485	Sugiyama	GPS1 COPS1 CSN1	HVKsPPREGsQGELtPANsQsRMstNM______________
Q13112	S410	Sugiyama	CHAF1B CAF1A CAF1P60 MPHOSPH7 MPP7	LNMRtPDtAKKTKsQtHRGssPGPRPVEGtPASRtQDPssP
Q13247	S297	Sugiyama	SRSF6 SFRS6 SRP55	RSRSPKENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsP
Q13247	S303	Sugiyama	SRSF6 SFRS6 SRP55	ENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKRAT
Q13263	S473	Sugiyama	TRIM28 KAP1 RNF96 TIF1B	sGDDPyssAEPHVsGVKRsRsGEGEVsGLMRKVPRVsLERL
Q13263	T415	Sugiyama	TRIM28 KAP1 RNF96 TIF1B	LNAWTKSAEAFGKIVAERPGtNstGPAPMAPPRAPGPLSKQ
Q13283	S232	Sugiyama	G3BP1 G3BP	EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13427	T358	Sugiyama	PPIG	PRRYRTPSRSRSRDRFRRsEtPPHWRQEMQRAQRMRVssGE
Q13438	S529	Sugiyama	OS9	sPELVKKHKKKRVVPKKPPPsPQPTEEDPEHRVRVRVTKLR
Q13501	S266	Sugiyama	SQSTM1 ORCA OSIL	AALsPLGIEVDIDVEHGGKRsRLtPVsPEssstEEKsssQP
Q13884	S87	Sugiyama	SNTB1 SNT2B1	SFCRGAGAGHPGAGGAQPPDsPAGVRTAFTDLPEQVPESIS
Q13895	S423	Sugiyama	BYSL ENP1	ELLRLQPHPQLsPEIRRELQsAVPRDVEDVPITVE______
Q14157	S477	Sugiyama	UBAP2L KIAA0144 NICE4	PsKstsAPQMsPGssDNQsssPQPAQQKLKQQKKKAsLTSK
Q14160	S1486	Sugiyama	SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL	RHQERLRVQsPEPPAPERALsPAELRALEAEKRALWRAARM
Q14160	S504	Sugiyama	SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL	MKRSIEGRRsEACPCQPDsGsPLPAEEEKRLsAESGLSEDS
Q14203	S31	Sugiyama	DCTN1	RTPSGSRMsAEASARPLRVGsRVEVIGKGHRGTVAYVGATL
Q14204	S2410	Sugiyama	DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325	GEDEAQRRRKGKEDEGEEAAsPMLQIQRDAATIMQPYFTSN
Q14247	S405	Sugiyama	CTTN EMS1	EEARRKLEEQARAKtQtPPVsPAPQPtEERLPssPVyEDAA
Q14247	Y421	Sugiyama	CTTN EMS1	tPPVsPAPQPtEERLPssPVyEDAAsFKAELsyRGPVsGtE
Q14258	S100	Sugiyama	TRIM25 EFP RNF147 ZNF147	DLAREPPADVWtPPARAsAPsPNAQVACDHCLKEAAVKTCL
Q14432	T311	Sugiyama	PDE3A	RsssVVsAEMSGCSSKSHRRtsLPCIPREQLMGHSEWDHKR
Q14498	S334	Sugiyama	RBM39 HCC1 RNPC2	FELAGRPMKVGHVTERtDAssAssFLDsDELERtGIDLGtT
Q14568	S52	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14677	S166	Sugiyama	CLINT1 ENTH EPN4 EPNR KIAA0171	REERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSKWDE
Q15293	T76	Sugiyama	RCN1 RCN	FQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGD
Q15637	S80	Sugiyama	SF1 ZFM1 ZNF162	DLTRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFR
Q15637	S82	Sugiyama	SF1 ZFM1 ZNF162	TRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFRTR
Q15642	S296	Sugiyama	TRIP10 CIP4 STOT STP	FARPGDVEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRS
Q15642	S495	Sugiyama	TRIP10 CIP4 STOT STP	VLsNRGDsLSRHARPPDPPAsAPPDsssNsAsQDtKESSEE
Q15738	S106	Sugiyama	NSDHL H105E3	CSRQDLyPALKGVNTVFHCAsPPPSSNNKELFYRVNYIGTK
Q15814	S330	Sugiyama	TBCC	RSKNNWNDVDDFNWLARDMAsPNWsILPEEERNIQWD____
Q16630	T157	Sugiyama	CPSF6 CFIM68	SKKLMDLLPKRELHGQNPVVtPCNKQFLsQFEMQSRKTTQS
Q16695	T46	Sugiyama	H3-4 H3FT HIST3H3	ARKsAPATGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
Q32MZ4	S733	Sugiyama	LRRFIP1 GCF2 TRIP	ssPAEPKsEDADRCtLPEHEsPsQDIsDACEAEsTERCEMS
Q58FF6	T36	Sugiyama	HSP90AB4P	LQELISNASDALDKIRyEsLtDPsKLDGGKELKIDIIPNPR
Q58FF7	T60	Sugiyama	HSP90AB3P HSP90BC	LQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPNPQ
Q58FF8	T60	Sugiyama	HSP90AB2P HSP90BB	LWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPNTQ
Q5JSH3	S50	Sugiyama	WDR44 RPH11	KVGLSTFKETENTAYKVGNEsPVQELKQDVSKKIIEsIIEE
Q5JSH3	S561	Sugiyama	WDR44 RPH11	KNAFDYFNNMRMKYNtEGRVsPsPsQEsLsssKsDTDtGVC
Q5SW79	T1533	Sugiyama	CEP170 FAM68A KAB KIAA0470	LPsPPKQKssPVNNHHsPGQtPtLGQPEARALHPAAVSAAA
Q5T200	S879	Sugiyama	ZC3H13 KIAA0853	EKHRLLsQVVRPQEsRsLsPsHLTEDRQGRWKEEDRKPERK
Q6GYQ0	S861	Sugiyama	RALGAPA1 GARNL1 KIAA0884 TULIP1	EFIAERLRSGNASTMTRRGssPGsLEIPKDLPDILNKQNQM
Q6GYQ0	T1002	Sugiyama	RALGAPA1 GARNL1 KIAA0884 TULIP1	TITGSESASPVHSPLGSRsQtPsPSTLNIDHMEQKDLQLDE
Q6GYQ0	T798	Sugiyama	RALGAPA1 GARNL1 KIAA0884 TULIP1	tGNEVFGALNEEQPLPRssstsDILEPFTVERAKVNKEDMS
Q6NW29	S23	Sugiyama	RWDD4 FAM28A RWDD4A	ANEDQEMELEALRSIyEGDEsFRELsPVSFQyRIGENGDPK
Q6NXT2	T45	Sugiyama	H3-5 H3F3C	AARKSTPSTCGVKPHRyRPGtVALREIRRYQKstELLIRKL
Q6S8J3	S1068	Sugiyama	POTEE A26C1A POTE2	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6UN15	S492	Sugiyama	FIP1L1 FIP1 RHE	DRDRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAE
Q6UN15	T494	Sugiyama	FIP1L1 FIP1 RHE	DRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAERG
Q6ZN18	S141	Sugiyama	AEBP2	SAESLVGSSGGSSSDETRsLsPGAAssssGDGDGKEGLEEP
Q71DI3	T46	Sugiyama	H3C15 HIST2H3A; H3C14 H3F2 H3FM HIST2H3C; H3C13 HIST2H3D	ARKsAPATGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
Q7L2J0	S217	Sugiyama	MEPCE BCDIN3	LNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPKDItD
Q7L2J0	S69	Sugiyama	MEPCE BCDIN3	RGPGRCAPsAGsPAAAVGREsPGAAAtsSSGPQAQQHRGGG
Q7L2J0	T213	Sugiyama	MEPCE BCDIN3	DPLNLNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPK
Q7Z2W4	S275	Sugiyama	ZC3HAV1 ZC3HDC2 PRO1677	QGsQEFLASASAsAERsCtPsPDQIsHRAsLEDAPVDDLtR
Q7Z2W4	T273	Sugiyama	ZC3HAV1 ZC3HDC2 PRO1677	FFQGsQEFLASASAsAERsCtPsPDQIsHRAsLEDAPVDDL
Q7Z417	S692	Sugiyama	NUFIP2 KIAA1321 PIG1	IWNLQKQDPKRIItyNEAMDsPDQ_________________
Q7Z4H7	S552	Sugiyama	HAUS6 DGT6 FAM29A KIAA1574	PFQKEQDHLVEEVARAVLsDsPQLsEGKEIKLEELIDsLGS
Q7Z4V5	S183	Sugiyama	HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604	KMsVSKRARKASSDLDQAsVsPSEEENSESSsESEKTsDQD
Q7Z4V5	S652	Sugiyama	HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604	GssEDLHDsVREGPDLDRPGsDRQERERARGDsEALDEEs_
Q7Z5K2	S221	Sugiyama	WAPL FOE KIAA0261 WAPAL	AsEIKETNDTWNSQFGKRPEsPsEIsPIKGsVRTGLFEWDN
Q7Z5L9	S240	Sugiyama	IRF2BP2	AAASLGSAQPTDLGAHKRPAsVsssAAVEHEQREAAAKEKQ
Q7Z5L9	S360	Sugiyama	IRF2BP2	EANGANGSKAVARTARKRKPsPEPEGEVGPPKINGEAQPWL
Q7Z6Z7	S2887	Sugiyama	HUWE1 KIAA0312 KIAA1578 UREB1 HSPC272	LEEAVGDTSAAGSSEQPRAGsstPGDAPPAVAEVQGRSDGs
Q86VM9	S607	Sugiyama	ZC3H18 NHN1	SRHSSFSGSRSRsRsFsssPsPsPtPsPHRPsIRTKGEPAP
Q86VM9	S609	Sugiyama	ZC3H18 NHN1	HSSFSGSRSRsRsFsssPsPsPtPsPHRPsIRTKGEPAPPP
Q86VQ1	S108	Sugiyama	GLCCI1	AAASLGSLPGPGAARGPsPssPtPPAAAAPAEQAPRAKGRP
Q86WR0	S187	Sugiyama	CCDC25	KKREKEEMKKKREMDELRSYssLMKVENMSSNQDGNDsDEF
Q8IWW6	S240	Sugiyama	ARHGAP12	SSSsTEQIRAttPPNQGRPDsPVyANLQELKISQSALPPLP
Q8IWW6	T231	Sugiyama	ARHGAP12	QDSEsGDELSSSsTEQIRAttPPNQGRPDsPVyANLQELKI
Q8IZ21	S118	Sugiyama	PHACTR4 PRO2963	PSDAMLKNGHTTPIGNARsssPVQVEEEPVRLAsLRKAIPE
Q8N556	S264	Sugiyama	AFAP1 AFAP	IKEAYSGCSGPVDSECPPPPssPVHKAELEKKLssERPssD
Q8N556	S265	Sugiyama	AFAP1 AFAP	KEAYSGCSGPVDSECPPPPssPVHKAELEKKLssERPssDG
Q8N684	S205	Sugiyama	CPSF7	IPPRAHsRDssDsADGRAtPsENLVPSSARVDKPPSVLPYF
Q8N684	T161	Sugiyama	CPSF7	LLELLPGKVLNGEKVDVRPAtRQNLsQFEAQARKRECVRVP
Q8N684	T203	Sugiyama	CPSF7	GGIPPRAHsRDssDsADGRAtPsENLVPSSARVDKPPSVLP
Q8N6T3	S343	Sugiyama	ARFGAP1 ARF1GAP	NIDQSFWETFGSAEPTKtRKsPssDsWtCADtstERRssDs
Q8N6T3	T340	Sugiyama	ARFGAP1 ARF1GAP	QNSNIDQSFWETFGSAEPTKtRKsPssDsWtCADtstERRs
Q8NBJ5	S612	Sugiyama	COLGALT1 GLT25D1 PSEC0241	QKMREQQALSREAKNsDVLQsPLDsAARDEL__________
Q8NBJ7	S256	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8NBJ7	S44	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	NGQATSMVQLQGGRFLMGtNsPDSRDGDGPVREATVKPFAI
Q8NBJ7	T278	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	IDtADGsANHRARVttRMGNtPDsAsDNLGFRCAADAGRPP
Q8NBS9	S426	Sugiyama	TXNDC5 TLP46 UNQ364/PRO700	KKVSEHSGGRDLDSLHRFVLsQAKDEL______________
Q8ND56	S183	Sugiyama	LSM14A C19orf13 FAM61A RAP55 RAP55A	GSAFTQDTRsLKtQLsQGRssPQLDPLRKsPtMEQAVQtAs
Q8NEY1	S312	Sugiyama	NAV1 KIAA1151 KIAA1213 POMFIL3 STEERIN1	TCYDsDDANPRsVssLsNRssPLSWRYGQSSPRLQAGDAPS
Q8TAD8	S35	Sugiyama	SNIP1	RHRDGDVVLPAGVVVKQERLsPEVAPPAHRRPDHsGGsPsP
Q8TC07	S675	Sugiyama	TBC1D15	TSAFQSNALPTLSASGARNDsPtQIPVssDVCRLtPA____
Q8TD19	S13	Sugiyama	NEK9 KIAA1995 NEK8 NERCC	________MsVLGEYERHCDsINSDFGSEsGGCGDssPGPS
Q8TEW0	S962	Sugiyama	PARD3 PAR3 PAR3A	DEGMEtLEEDTEESSRsGREsVstAsDQPsHsLERQMNGNQ
Q8WVC0	S495	Sugiyama	LEO1 RDL	QGtGLQGQAVFKTKLTFRPHstDSATHRKMTLSLADRCSKT
Q8WVV9	S75	Sugiyama	HNRNPLL HNRPLL SRRF BLOCK24	GGGRsFsQPEAGGsHHKVsVsPVVHVRGLCEsVVEADLVEA
Q8WWM7	S111	Sugiyama	ATXN2L A2D A2LG A2LP A2RP	PGAAAIGsARGQstGKGPPQsPVFEGVyNNSRMLHFLTAVV
Q8WXI9	S122	Sugiyama	GATAD2B KIAA1150	DEPVDMSARRsEPERGRLtPsPDIIVLsDNEAssPRsSsRM
Q8WXI9	T120	Sugiyama	GATAD2B KIAA1150	INDEPVDMSARRsEPERGRLtPsPDIIVLsDNEAssPRsSs
Q8WY36	S844	Sugiyama	BBX HBP2	KRKARKTKITHLVRtADGRVsPAGGTLDDKPKEQLQRSLPK
Q92466	S26	Sugiyama	DDB2	RPETQKTSEIVLRPRNKRsRsPLELEPEAKKLCAKGSGPSR
Q92620	S234	Sugiyama	DHX38 DDX38 KIAA0224 PRP16	TWEEEDsGyGSSRRSQWEsPsPTPSYRDSERSHRLSTRDRD
Q96B36	S212	Sugiyama	AKT1S1 PRAS40	GFKEKRtEARssDEENGPPssPDLDRIAAsMRALVLREAED
Q96BY7	S1395	Sugiyama	ATG2B C14orf103	ADMKPGAFQRRSKVDSSGRSsSRGPVLPEADQQMLRDLMSD
Q96C19	S74	Sugiyama	EFHD2 SWS1	ELSAKLLRRADLNQGIGEPQsPsRRVFNPytEFKEFSRKQI
Q96D46	S462	Sugiyama	NMD3 CGI-07	FLEDLEEDEAIRKNVNIyRDsAIPVEsDtDDEGAPRISLAE
Q96EN8	S530	Sugiyama	MOCOS	APSADSQADVIPAVMGRRsLsPQEDALTGSRVWNNSSTVNA
Q96L14	T242	Sugiyama	CEP170P1 CEP170L KIAA0470L	LPsPPKQKssPVNNHHsPGQtPtLGQPEARALHPAAVSAAA
Q96MH2	S76	Sugiyama	HEXIM2 L3	EDLAGAVGGLGWNsRsPRtQsPGGCsAEAVLARKKHRRRPS
Q96QF0	S165	Sugiyama	RAB3IP RABIN8	DGSDDIFGLsTDSLSRLRsPsVLEVREKGYERLKEELAKAQ
Q96QK1	S783	Sugiyama	VPS35 MEM3 TCCCTA00141	tEQINKHFHNtLEHLRLRREsPEsEGPIyEGLIL_______
Q96S44	T8	Sugiyama	TP53RK C20orf64 PRPK	_____________MAAARAttPADGEEPAPEAEALAAARER
Q96T37	S670	Sugiyama	RBM15 OTT OTT1	GRHLDRsPEsDRPRKRHCAPsPDRsPELsssRDRYNsDNDR
Q99426	S163	Sugiyama	TBCB CG22 CKAP1	AEAAQRLAEEKAQASSIPVGsRCEVRAAGQSPRRGTVMYVG
Q99733	S53	Sugiyama	NAP1L4 NAP2	QNPRVLAALQERLDNVPHtPssyIEtLPKAVKRRINALKQL
Q99733	T51	Sugiyama	NAP1L4 NAP2	VMQNPRVLAALQERLDNVPHtPssyIEtLPKAVKRRINALK
Q9BQG0	S1232	Sugiyama	MYBBP1A P160	KRNRTKAKVPAQANGtPtTKsPAPGAPtRsPstPAKsPKLQ
Q9BSJ8	S1034	Sugiyama	ESYT1 FAM62A KIAA0747 MBC2	LLPDKNRGTKRRTSQKKRtLsPEFNERFEWELPLDEAQRRK
Q9BTA9	S525	Sugiyama	WAC KIAA1844	QGHEPVsPRSLQRsssQRsPsPGPNHtsNssNAsNATVVPQ
Q9BTC0	T1469	Sugiyama	DIDO1 C20orf158 DATF1 KIAA0333	CADVRRNsVERPAEPVAGAAtPsLVEQQKMLEELNKQIEEQ
Q9BV68	S34	Sugiyama	RNF126	HCCsVEIVPRLPDYICPRCEsGFIEELPEETRSTENGSAPS
Q9BX95	S112	Sugiyama	SGPP1 SPP1	GLAAELGPAsPRRAGALRRNsLtGEEGQLARVSNWPLYCLF
Q9BY44	S506	Sugiyama	EIF2A CDA02 MSTP004 MSTP089	KNQRKHEAKKAAKQEARsDKsPDLAPtPAPQstPRNtVsQs
Q9BY44	T512	Sugiyama	EIF2A CDA02 MSTP004 MSTP089	EAKKAAKQEARsDKsPDLAPtPAPQstPRNtVsQsIsGDPE
Q9BYG3	T234	Sugiyama	NIFK MKI67IP NOPP34	KKKVsGtLDtPEKtVDsQGPtPVCtPtFLERRKsQVAELND
Q9BYG3	T238	Sugiyama	NIFK MKI67IP NOPP34	sGtLDtPEKtVDsQGPtPVCtPtFLERRKsQVAELNDDDKD
Q9BYX7	S368	Sugiyama	POTEKP ACTBL3 FKSG30	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9C0C2	S1103	Sugiyama	TNKS1BP1 KIAA1741 TAB182	KRGWVGEFSLSVGPQREAAFsPGQQDWsRDFCIEASERsyQ
Q9C0C2	S422	Sugiyama	TNKS1BP1 KIAA1741 TAB182	RTFPSGGEEEAKGDAHLRPtsLVQRRFsEGVLQsPsQDQEK
Q9C0C2	S435	Sugiyama	TNKS1BP1 KIAA1741 TAB182	DAHLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAALPQGQG
Q9C0C2	S601	Sugiyama	TNKS1BP1 KIAA1741 TAB182	LPLQQAEERyEsQEPLAGQEsPLPLATREAALPILEPVLGQ
Q9C0C2	S672	Sugiyama	TNKS1BP1 KIAA1741 TAB182	TLARAETtQARtEAQDLCRAsPEPPGPEsSSRWLDDLLAsP
Q9C0C2	S983	Sugiyama	TNKS1BP1 KIAA1741 TAB182	sGGsSRtLDAQDRsFGtRPLssGFsPEEAQQQDEEFEKKIP
Q9C0C2	S984	Sugiyama	TNKS1BP1 KIAA1741 TAB182	GGsSRtLDAQDRsFGtRPLssGFsPEEAQQQDEEFEKKIPs
Q9C0C2	S987	Sugiyama	TNKS1BP1 KIAA1741 TAB182	SRtLDAQDRsFGtRPLssGFsPEEAQQQDEEFEKKIPsVED
Q9C0C9	S115	Sugiyama	UBE2O KIAA1734	GRGssGCSEAGGAGHEEGRAsPLRRGYVRVQWYPEGVKQHV
Q9H2U2	S317	Sugiyama	PPA2 HSPC124	DSPFRCtQEEARsLVEsVsssPNKEsNEEEQVWHFLGK___
Q9H4A3	S1261	Sugiyama	WNK1 HSN2 KDP KIAA0344 PRKWNK1	GIPTSSLTQVVHSAGRRFIVsPVPEsRLRESKVFPSEITDT
Q9H4A4	S19	Sugiyama	RNPEP APB	__MAsGEHsPGsGAARRPLHsAQAVDVAsAsNFRAFELLHL
Q9H4A5	S112	Sugiyama	GOLPH3L GPP34R	EPPTMRKKRLLDRKVLLKsDsPTGDVLLDETLKHIKATEPT
Q9H4G0	S784	Sugiyama	EPB41L1 KIAA0338	KGAAAMIPGPQTVATEIRsLsPIIGKDVLtstyGAtAEtLS
Q9HA77	S548	Sugiyama	CARS2 OK/SW-cl.10	TLRRGLTAHGINIKDRssttstWELLDQRTKDQKSAG____
Q9HA77	T547	Sugiyama	CARS2 OK/SW-cl.10	DTLRRGLTAHGINIKDRssttstWELLDQRTKDQKSAG___
Q9HAU0	S471	Sugiyama	PLEKHA5 KIAA1686 PEPP2	MARYPEGYRtLPRNSKTRPEsICSVtPsTHDKTLGPGAEEK
Q9HC35	S144	Sugiyama	EML4 C2orf2 EMAPL4	GQREKKEEsHsNDQsPQIRAsPsPQPssQPLQIHRQtPEsK
Q9HC35	S146	Sugiyama	EML4 C2orf2 EMAPL4	REKKEEsHsNDQsPQIRAsPsPQPssQPLQIHRQtPEsKNA
Q9HCN4	S301	Sugiyama	GPN1 MBDIN RPAP4 XAB1 HUSSY-23	ANAESQQQREQLERLRKDMGsVALDAGtAKDsLsPVLHPsD
Q9NPI6	S523	Sugiyama	DCP1A SMIF	APSVFQQTVTRSSDLERKAssPsPLtIGtPEsQRKPSIILS
Q9NPI6	S525	Sugiyama	DCP1A SMIF	SVFQQTVTRSSDLERKAssPsPLtIGtPEsQRKPSIILSKs
Q9NR20	S16	Sugiyama	DYRK4	_____MPASELKASEIPFHPsIKTQDPKAEEKSPKKQKVTL
Q9NR20	S420	Sugiyama	DYRK4	IHQSRNLKPQPRPQTLRKSNsFFPSETRKDKVQGCHHSSRK
Q9NR20	S498	Sugiyama	DYRK4	QLPQLVDAPKKSEAAVGAEVsMtsPGQSKNFSLKNTNVLPP
Q9NR20	S501	Sugiyama	DYRK4	QLVDAPKKSEAAVGAEVsMtsPGQSKNFSLKNTNVLPPIV_
Q9NR20	T476	Sugiyama	DYRK4	PTKHVQHSGDQQDCLQHGADtVQLPQLVDAPKKSEAAVGAE
Q9NR20	T500	Sugiyama	DYRK4	PQLVDAPKKSEAAVGAEVsMtsPGQSKNFSLKNTNVLPPIV
Q9NR20	Y264	SIGNOR\|PSP	DYRK4	ASVKVIDFGSSCYEHQKVYTyIQSRFYRSPEVILGHPYDVA
Q9NUQ3	S97	Sugiyama	TXLNG CXorf15 ELRG LSR5	KHSLEEDEGsDFItENRNLVsPAyCtQEsREEIPGGEARTD
Q9NWB6	S77	Sugiyama	ARGLU1	RsRstNTAVSRRERDRERAssPPDRIDIFGRTVSKRSSLDE
Q9NXH9	S524	Sugiyama	TRMT1	KECPVKRERLsETsPAFRILsVEPRLQANFTIREDANPSSR
Q9NY33	S218	Sugiyama	DPP3	tRLFKEVDGEGKPYYEVRLAsVLGSEPsLDsEVTSKLKSYE
Q9UGV2	S341	Sugiyama	NDRG3	MTRLARsRtHstsssLGsGEsPFsRsVtsNQsDGtQESCEs
Q9UI15	S185	Sugiyama	TAGLN3 NP25	EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UII2	S63	Sugiyama	ATP5IF1 ATPI ATPIF1	AGGAFGKREQAEEERyFRAQsREQLAALKKHHEEEIVHHKK
Q9UMZ2	S1082	Sugiyama	SYNRG AP1GBP1 SYNG	FDLSVQGSHKRsLsLGDKEIsRssPsPALEQPFRDRsNtLN
Q9UMZ2	S1087	Sugiyama	SYNRG AP1GBP1 SYNG	QGSHKRsLsLGDKEIsRssPsPALEQPFRDRsNtLNEKPAL
Q9UNX3	S32	Sugiyama	RPL26L1 RPL26P1	sKNRKRHFNAPSHVRRKIMssPLSKELRQKYNVRSMPIRKD
Q9UNZ2	T73	Sugiyama	NSFL1C UBXN2C	ISQATPssVsRGTAPSDNRVtsFRDLIHDQDEDEEEEEGQR
Q9UQ35	S1103	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35	S1318	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	VPsMASSWGGPHFsPEHKELsNsPLRENsFGsPLEFRNsGP
Q9UQ35	S1329	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	HFsPEHKELsNsPLRENsFGsPLEFRNsGPLGTEMNtGFss
Q9UQ35	S1648	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	APRALPRRSRSGSSSKGRGPsPEGssstEssPEHPPKSRTA
Q9UQ35	S2132	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9UQ35	S2398	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	ANLtsPRVPLsAyERVsGRtsPPLLDRARsRtPPsAPsQsR
Q9UQ35	S2694	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	RSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQSSs
Q9UQ35	S322	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	RRGEGDAPFsEPGttstQRPssPEtAtKQPssPYEDKDKDK
Q9UQ35	S377	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sstGPEPPAPtPLLAERHGGsPQPLAttPLsQEPVNPPsEA
Q9UQ35	T328	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	APFsEPGttstQRPssPEtAtKQPssPYEDKDKDKKEKsAt
Q9UQ35	T383	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	PPAPtPLLAERHGGsPQPLAttPLsQEPVNPPsEAsPtRDR
Q9Y2B0	S65	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2V2	S30	Sugiyama	CARHSP1	QPPtHQAsVGLLDtPRsRERsPsPLRGNVVPsPLPtRRtRt
Q9Y2V2	S32	Sugiyama	CARHSP1	PtHQAsVGLLDtPRsRERsPsPLRGNVVPsPLPtRRtRtFs
Q9Y2V2	S41	Sugiyama	CARHSP1	LDtPRsRERsPsPLRGNVVPsPLPtRRtRtFsAtVRASQGP
Q9Y2W2	S237	Sugiyama	WBP11 NPWBP SIPP1 SNP70	RKVGFALDLPPRRRDEDMLysPELAQRGHDDDVSSTSEDDG
Q9Y3D9	T160	Sugiyama	MRPS23 CGI-138 HSPC329	TQHGGSHVSRKSEHLSVRPQtALEENETQKEVPQDQHLEAP

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Chromatin organization	R-HSA-4839726	4.366367e-08	7.360
Cell Cycle	R-HSA-1640170	5.329288e-08	7.273
Chromatin modifying enzymes	R-HSA-3247509	1.316526e-07	6.881
Cell Cycle, Mitotic	R-HSA-69278	3.195442e-06	5.495
Nuclear Envelope Breakdown	R-HSA-2980766	1.578774e-05	4.802
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.802158e-05	4.744
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.815407e-05	4.550
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	6.913901e-05	4.160
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	1.030440e-04	3.987
Signaling by NTRKs	R-HSA-166520	1.198789e-04	3.921
Regulation of TP53 Activity	R-HSA-5633007	1.178986e-04	3.928
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.398546e-04	3.854
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	1.587381e-04	3.799
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.901736e-04	3.721
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.901736e-04	3.721
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	2.011601e-04	3.696
Transport of the SLBP independent Mature mRNA	R-HSA-159227	2.912209e-04	3.536
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	2.965716e-04	3.528
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	3.732534e-04	3.428
Mitotic Prophase	R-HSA-68875	4.049790e-04	3.393
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	4.465209e-04	3.350
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	5.736568e-04	3.241
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	5.736568e-04	3.241
M Phase	R-HSA-68886	6.631365e-04	3.178
PKMTs methylate histone lysines	R-HSA-3214841	7.432687e-04	3.129
Deubiquitination	R-HSA-5688426	7.640998e-04	3.117
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	7.590507e-04	3.120
Apoptotic cleavage of cellular proteins	R-HSA-111465	7.300914e-04	3.137
Signal Transduction	R-HSA-162582	8.011736e-04	3.096
HATs acetylate histones	R-HSA-3214847	8.393030e-04	3.076
IPs transport between nucleus and cytosol	R-HSA-1855170	9.209414e-04	3.036
Vpr-mediated nuclear import of PICs	R-HSA-180910	9.273582e-04	3.033
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	1.151901e-03	2.939
NS1 Mediated Effects on Host Pathways	R-HSA-168276	1.398357e-03	2.854
Nuclear import of Rev protein	R-HSA-180746	1.429259e-03	2.845
Interactions of Vpr with host cellular proteins	R-HSA-176033	1.700145e-03	2.770
Polo-like kinase mediated events	R-HSA-156711	1.893499e-03	2.723
NRAGE signals death through JNK	R-HSA-193648	1.944931e-03	2.711
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	2.054190e-03	2.687
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	2.145802e-03	2.668
G1/S-Specific Transcription	R-HSA-69205	2.151348e-03	2.667
Transcriptional Regulation by TP53	R-HSA-3700989	2.029457e-03	2.693
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	2.611689e-03	2.583
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	2.716439e-03	2.566
NGF-stimulated transcription	R-HSA-9031628	3.211997e-03	2.493
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	3.419450e-03	2.466
Death Receptor Signaling	R-HSA-73887	2.939575e-03	2.532
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	3.149633e-03	2.502
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	3.774465e-03	2.423
Oncogenic MAPK signaling	R-HSA-6802957	4.181164e-03	2.379
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	4.217345e-03	2.375
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	4.452132e-03	2.351
tRNA processing in the nucleus	R-HSA-6784531	4.709329e-03	2.327
Interactions of Rev with host cellular proteins	R-HSA-177243	4.496019e-03	2.347
Transcriptional regulation by RUNX1	R-HSA-8878171	4.920569e-03	2.308
Signaling by Hippo	R-HSA-2028269	5.090788e-03	2.293
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	5.593694e-03	2.252
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	5.593694e-03	2.252
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	5.593694e-03	2.252
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	5.861682e-03	2.232
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	5.334321e-03	2.273
Apoptotic execution phase	R-HSA-75153	5.682313e-03	2.245
Signaling by WNT in cancer	R-HSA-4791275	6.197431e-03	2.208
Circadian clock	R-HSA-9909396	6.357065e-03	2.197
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	6.989766e-03	2.156
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	7.439551e-03	2.128
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	7.439551e-03	2.128
G alpha (12/13) signalling events	R-HSA-416482	7.716197e-03	2.113
Activation of RAC1	R-HSA-428540	9.350025e-03	2.029
Mitotic Telophase/Cytokinesis	R-HSA-68884	9.350025e-03	2.029
Signaling by AXIN mutants	R-HSA-4839735	9.350025e-03	2.029
Signaling by AMER1 mutants	R-HSA-4839748	9.350025e-03	2.029
S Phase	R-HSA-69242	9.343996e-03	2.029
Viral Messenger RNA Synthesis	R-HSA-168325	9.014132e-03	2.045
G1/S Transition	R-HSA-69206	9.950471e-03	2.002
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	1.032619e-02	1.986
Interleukin-37 signaling	R-HSA-9008059	1.146612e-02	1.941
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	1.146746e-02	1.941
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	1.216604e-02	1.915
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.250353e-02	1.903
TGFBR3 expression	R-HSA-9839394	1.233995e-02	1.909
Mitotic Prometaphase	R-HSA-68877	1.309981e-02	1.883
Signaling by LTK	R-HSA-9842663	1.250353e-02	1.903
p75 NTR receptor-mediated signalling	R-HSA-193704	1.284626e-02	1.891
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	1.317941e-02	1.880
mRNA 3'-end processing	R-HSA-72187	1.325755e-02	1.878
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.345741e-02	1.871
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	1.544371e-02	1.811
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	1.544371e-02	1.811
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	1.484780e-02	1.828
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	1.581391e-02	1.801
Cell Cycle Checkpoints	R-HSA-69620	1.488979e-02	1.827
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	1.589749e-02	1.799
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	1.589749e-02	1.799
Diseases of mitotic cell cycle	R-HSA-9675126	1.606629e-02	1.794
RNA Polymerase II Transcription Termination	R-HSA-73856	1.875638e-02	1.727
mRNA Splicing	R-HSA-72172	1.788386e-02	1.748
Regulation of PTEN gene transcription	R-HSA-8943724	1.672796e-02	1.777
Signaling by ERBB2	R-HSA-1227986	1.672796e-02	1.777
Ovarian tumor domain proteases	R-HSA-5689896	1.678594e-02	1.775
MAP kinase activation	R-HSA-450294	1.875638e-02	1.727
Gastrulation	R-HSA-9758941	1.674753e-02	1.776
Transcriptional Regulation by MECP2	R-HSA-8986944	1.704022e-02	1.769
Cardiogenesis	R-HSA-9733709	1.882243e-02	1.725
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.976758e-02	1.704
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.976758e-02	1.704
Depolymerization of the Nuclear Lamina	R-HSA-4419969	2.046609e-02	1.689
G2/M Transition	R-HSA-69275	2.053525e-02	1.687
ISG15 antiviral mechanism	R-HSA-1169408	2.155998e-02	1.666
Diseases of Telomere Maintenance	R-HSA-9673013	2.358768e-02	1.627
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.358768e-02	1.627
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.358768e-02	1.627
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.358768e-02	1.627
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.358768e-02	1.627
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	2.309028e-02	1.637
mRNA Splicing - Major Pathway	R-HSA-72163	2.170369e-02	1.663
Mitotic G2-G2/M phases	R-HSA-453274	2.320748e-02	1.634
Transcriptional Regulation by E2F6	R-HSA-8953750	2.231506e-02	1.651
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	2.437474e-02	1.613
Interleukin-17 signaling	R-HSA-448424	2.489799e-02	1.604
Signaling by APC mutants	R-HSA-4839744	2.607978e-02	1.584
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	2.607978e-02	1.584
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	2.607978e-02	1.584
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	2.607978e-02	1.584
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	2.628491e-02	1.580
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	2.869826e-02	1.542
SHC1 events in ERBB2 signaling	R-HSA-1250196	2.869826e-02	1.542
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	2.818054e-02	1.550
DCC mediated attractive signaling	R-HSA-418885	2.628491e-02	1.580
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	2.869826e-02	1.542
Adipogenesis	R-HSA-9843745	2.877250e-02	1.541
FLT3 Signaling	R-HSA-9607240	2.907213e-02	1.537
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	2.950957e-02	1.530
snRNP Assembly	R-HSA-191859	3.002485e-02	1.523
Metabolism of non-coding RNA	R-HSA-194441	3.002485e-02	1.523
Formation of definitive endoderm	R-HSA-9823730	3.018940e-02	1.520
Transcriptional regulation by small RNAs	R-HSA-5578749	3.029039e-02	1.519
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	3.148482e-02	1.502
Disinhibition of SNARE formation	R-HSA-114516	3.148482e-02	1.502
Cohesin Loading onto Chromatin	R-HSA-2470946	3.148482e-02	1.502
Signaling by GSK3beta mutants	R-HSA-5339716	3.355052e-02	1.474
SWI/SNF chromatin remodelers	R-HSA-9932451	3.231017e-02	1.491
ATP-dependent chromatin remodelers	R-HSA-9932444	3.231017e-02	1.491
Cellular response to heat stress	R-HSA-3371556	3.285049e-02	1.483
RET signaling	R-HSA-8853659	3.336175e-02	1.477
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	3.449136e-02	1.462
RUNX2 regulates bone development	R-HSA-8941326	3.336175e-02	1.477
Inhibition of TSC complex formation by PKB	R-HSA-165181	3.462699e-02	1.461
Mitotic Anaphase	R-HSA-68882	3.514980e-02	1.454
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	3.545682e-02	1.450
ERK/MAPK targets	R-HSA-198753	3.605115e-02	1.443
Mitotic Metaphase and Anaphase	R-HSA-2555396	3.702560e-02	1.431
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	4.215131e-02	1.375
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	3.856378e-02	1.414
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	3.960163e-02	1.402
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	3.774764e-02	1.423
Transcriptional regulation of granulopoiesis	R-HSA-9616222	4.066300e-02	1.391
Heme signaling	R-HSA-9707616	4.066300e-02	1.391
Inositol phosphate metabolism	R-HSA-1483249	4.032442e-02	1.394
RUNX3 regulates NOTCH signaling	R-HSA-8941856	4.222572e-02	1.374
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	4.222572e-02	1.374
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	4.222572e-02	1.374
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	4.222572e-02	1.374
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	4.222572e-02	1.374
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	4.222572e-02	1.374
Interleukin-15 signaling	R-HSA-8983432	4.222572e-02	1.374
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	4.253603e-02	1.371
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	4.299462e-02	1.367
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	4.374843e-02	1.359
Cyclin E associated events during G1/S transition	R-HSA-69202	4.628450e-02	1.335
ARL13B-mediated ciliary trafficking of INPP5E	R-HSA-5624958	4.917714e-02	1.308
Breakdown of the nuclear lamina	R-HSA-352238	4.917714e-02	1.308
Notch-HLH transcription pathway	R-HSA-350054	4.991281e-02	1.302
Hedgehog 'on' state	R-HSA-5632684	5.052686e-02	1.296
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	5.053836e-02	1.296
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	5.053836e-02	1.296
RAF activation	R-HSA-5673000	5.628282e-02	1.250
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	5.198854e-02	1.284
Transcriptional regulation by RUNX3	R-HSA-8878159	5.713416e-02	1.243
PTEN Regulation	R-HSA-6807070	5.151795e-02	1.288
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	5.316714e-02	1.274
Formation of axial mesoderm	R-HSA-9796292	5.213313e-02	1.283
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	5.503243e-02	1.259
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	5.461335e-02	1.263
Signaling by TGFBR3	R-HSA-9839373	5.787884e-02	1.237
AURKA Activation by TPX2	R-HSA-8854518	5.866497e-02	1.232
Kinesins	R-HSA-983189	6.248780e-02	1.204
Regulation of KIT signaling	R-HSA-1433559	6.328261e-02	1.199
Signalling to ERKs	R-HSA-187687	6.333908e-02	1.198
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	6.547680e-02	1.184
Germ layer formation at gastrulation	R-HSA-9754189	6.644716e-02	1.178
Signal attenuation	R-HSA-74749	6.884597e-02	1.162
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	6.937701e-02	1.159
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	6.937701e-02	1.159
Regulation of CDH19 Expression and Function	R-HSA-9764302	6.937701e-02	1.159
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	6.937701e-02	1.159
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	6.937701e-02	1.159
Mitotic Spindle Checkpoint	R-HSA-69618	7.026172e-02	1.153
Regulation of cortical dendrite branching	R-HSA-8985801	8.107394e-02	1.091
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	7.566694e-02	1.121
Beta-catenin phosphorylation cascade	R-HSA-196299	7.566694e-02	1.121
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	7.727883e-02	1.112
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	8.073046e-02	1.093
Loss of Nlp from mitotic centrosomes	R-HSA-380259	8.073046e-02	1.093
Degradation of beta-catenin by the destruction complex	R-HSA-195253	8.141643e-02	1.089
Regulation of TP53 Expression	R-HSA-6804754	8.107394e-02	1.091
Epigenetic regulation of gene expression	R-HSA-212165	7.400957e-02	1.131
TNF signaling	R-HSA-75893	7.951595e-02	1.100
Cellular Senescence	R-HSA-2559583	7.310277e-02	1.136
Formation of the anterior neural plate	R-HSA-9823739	7.566694e-02	1.121
Gene expression (Transcription)	R-HSA-74160	7.300770e-02	1.137
Metabolism of RNA	R-HSA-8953854	7.726666e-02	1.112
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	8.162617e-02	1.088
Signaling by SCF-KIT	R-HSA-1433557	8.262603e-02	1.083
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	7.431120e-02	1.129
Signaling by NOTCH3	R-HSA-9012852	7.281340e-02	1.138
G0 and Early G1	R-HSA-1538133	8.309004e-02	1.080
TCF dependent signaling in response to WNT	R-HSA-201681	8.432757e-02	1.074
Formation of the posterior neural plate	R-HSA-9832991	8.479104e-02	1.072
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	8.904577e-02	1.050
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	8.926288e-02	1.049
Differentiation of T cells	R-HSA-9945266	8.926288e-02	1.049
Activation of SMO	R-HSA-5635838	8.926288e-02	1.049
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	8.926288e-02	1.049
Prolonged ERK activation events	R-HSA-169893	8.926288e-02	1.049
WNT5A-dependent internalization of FZD4	R-HSA-5099900	8.926288e-02	1.049
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	9.089682e-02	1.041
G2/M DNA replication checkpoint	R-HSA-69478	9.089682e-02	1.041
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	9.089682e-02	1.041
DNA Repair	R-HSA-73894	9.151430e-02	1.039
Defective Base Excision Repair Associated with NEIL1	R-HSA-9616334	1.107466e-01	0.956
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.107466e-01	0.956
Deletions in the AMER1 gene destabilize the destruction complex	R-HSA-5467343	1.107466e-01	0.956
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	1.107466e-01	0.956
Deletions in the AXIN1 gene destabilize the destruction complex	R-HSA-5467345	1.107466e-01	0.956
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	1.023624e-01	0.990
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	1.040326e-01	0.983
TRAF3-dependent IRF activation pathway	R-HSA-918233	1.040326e-01	0.983
Processing of Intronless Pre-mRNAs	R-HSA-77595	1.040326e-01	0.983
mRNA Splicing - Minor Pathway	R-HSA-72165	1.087877e-01	0.963
Amplification of signal from the kinetochores	R-HSA-141424	9.373345e-02	1.028
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	9.373345e-02	1.028
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	1.018925e-01	0.992
PIP3 activates AKT signaling	R-HSA-1257604	1.078823e-01	0.967
Neurexins and neuroligins	R-HSA-6794361	1.011419e-01	0.995
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	9.767135e-02	1.010
Signaling downstream of RAS mutants	R-HSA-9649948	1.087877e-01	0.963
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.087877e-01	0.963
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.087877e-01	0.963
Hedgehog 'off' state	R-HSA-5610787	1.103195e-01	0.957
Resolution of D-Loop Structures	R-HSA-5693537	1.032304e-01	0.986
Nuclear RNA decay	R-HSA-9930044	9.284650e-02	1.032
Signaling by RAS mutants	R-HSA-6802949	1.087877e-01	0.963
Regulation of TNFR1 signaling	R-HSA-5357905	1.087877e-01	0.963
Estrogen-dependent gene expression	R-HSA-9018519	9.821918e-02	1.008
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	1.094725e-01	0.961
Regulation of MECP2 expression and activity	R-HSA-9022692	9.284650e-02	1.032
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	1.032304e-01	0.986
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.001897e-01	0.999
Signaling by ALK	R-HSA-201556	9.696714e-02	1.013
Disorders of Developmental Biology	R-HSA-9675151	1.040326e-01	0.983
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	1.142326e-01	0.942
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	1.148042e-01	0.940
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	1.148042e-01	0.940
RUNX3 regulates WNT signaling	R-HSA-8951430	1.148042e-01	0.940
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	1.148042e-01	0.940
SOS-mediated signalling	R-HSA-112412	1.148042e-01	0.940
Cation-coupled Chloride cotransporters	R-HSA-426117	1.148042e-01	0.940
Displacement of DNA glycosylase by APEX1	R-HSA-110357	1.148042e-01	0.940
Transcriptional Regulation by VENTX	R-HSA-8853884	1.170183e-01	0.932
MET activates STAT3	R-HSA-8875791	1.175687e-01	0.930
MET interacts with TNS proteins	R-HSA-8875513	1.175687e-01	0.930
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	1.175687e-01	0.930
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	1.175687e-01	0.930
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	1.175687e-01	0.930
Drug-mediated inhibition of MET activation	R-HSA-9734091	2.092342e-01	0.679
Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)	R-HSA-9036092	2.092342e-01	0.679
Defective Mismatch Repair Associated With MLH1	R-HSA-5545483	2.092342e-01	0.679
Defective Mismatch Repair Associated With PMS2	R-HSA-5632987	2.092342e-01	0.679
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	2.092342e-01	0.679
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	2.092342e-01	0.679
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	2.092342e-01	0.679
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	1.572528e-01	0.803
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	1.572528e-01	0.803
Signaling by MAP2K mutants	R-HSA-9652169	1.572528e-01	0.803
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	1.572528e-01	0.803
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	1.572528e-01	0.803
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	2.968191e-01	0.528
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	R-HSA-5083628	2.968191e-01	0.528
XAV939 stabilizes AXIN	R-HSA-5545619	2.968191e-01	0.528
Defective GFPT1 causes CMSTA1	R-HSA-4085023	2.968191e-01	0.528
PTEN Loss of Function in Cancer	R-HSA-5674404	2.968191e-01	0.528
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	2.968191e-01	0.528
Defective MMADHC causes MMAHCD	R-HSA-3359473	2.968191e-01	0.528
Signaling by TCF7L2 mutants	R-HSA-5339700	2.968191e-01	0.528
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5619101	2.968191e-01	0.528
Defective VWF binding to collagen type I	R-HSA-9845622	2.968191e-01	0.528
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5660686	2.968191e-01	0.528
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	1.989733e-01	0.701
IRS activation	R-HSA-74713	1.989733e-01	0.701
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	1.989733e-01	0.701
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	1.989733e-01	0.701
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	1.989733e-01	0.701
MET activates RAS signaling	R-HSA-8851805	1.214511e-01	0.916
RUNX3 regulates p14-ARF	R-HSA-8951936	1.214511e-01	0.916
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.214511e-01	0.916
SHC-related events triggered by IGF1R	R-HSA-2428933	1.214511e-01	0.916
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	1.684904e-01	0.773
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.684904e-01	0.773
MAPK1 (ERK2) activation	R-HSA-112411	1.684904e-01	0.773
Nef Mediated CD8 Down-regulation	R-HSA-182218	2.417929e-01	0.617
PKB-mediated events	R-HSA-109703	2.417929e-01	0.617
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	2.417929e-01	0.617
PDE3B signalling	R-HSA-165160	2.417929e-01	0.617
PTK6 Regulates Cell Cycle	R-HSA-8849470	2.417929e-01	0.617
Signaling by RNF43 mutants	R-HSA-5340588	2.417929e-01	0.617
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	3.747077e-01	0.426
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	3.747077e-01	0.426
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	3.747077e-01	0.426
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	R-HSA-5083629	3.747077e-01	0.426
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	3.747077e-01	0.426
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	3.747077e-01	0.426
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	3.747077e-01	0.426
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	R-HSA-5083633	3.747077e-01	0.426
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	3.747077e-01	0.426
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	3.747077e-01	0.426
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	3.747077e-01	0.426
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	3.747077e-01	0.426
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.747077e-01	0.426
Enhanced cleavage of VWF variant by ADAMTS13	R-HSA-9845619	3.747077e-01	0.426
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	3.747077e-01	0.426
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.747077e-01	0.426
Defective VWF cleavage by ADAMTS13 variant	R-HSA-9845621	3.747077e-01	0.426
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	1.419303e-01	0.848
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	1.419303e-01	0.848
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	1.419303e-01	0.848
MAPK3 (ERK1) activation	R-HSA-110056	1.976090e-01	0.704
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.636602e-01	0.786
Retrograde neurotrophin signalling	R-HSA-177504	1.636602e-01	0.786
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	2.849570e-01	0.545
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	2.849570e-01	0.545
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	1.368789e-01	0.864
ChREBP activates metabolic gene expression	R-HSA-163765	2.278156e-01	0.642
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	2.278156e-01	0.642
Activated NTRK3 signals through RAS	R-HSA-9034864	2.278156e-01	0.642
Erythropoietin activates RAS	R-HSA-9027284	1.864919e-01	0.729
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	1.864919e-01	0.729
Impaired BRCA2 binding to PALB2	R-HSA-9709603	1.548217e-01	0.810
Negative regulation of MET activity	R-HSA-6807004	1.736740e-01	0.760
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.736740e-01	0.760
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	1.736740e-01	0.760
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	1.736740e-01	0.760
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	1.736740e-01	0.760
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	1.736740e-01	0.760
Condensation of Prometaphase Chromosomes	R-HSA-2514853	2.588076e-01	0.587
Activated NTRK2 signals through RAS	R-HSA-9026519	2.588076e-01	0.587
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	2.588076e-01	0.587
ERKs are inactivated	R-HSA-202670	2.588076e-01	0.587
NOSTRIN mediated eNOS trafficking	R-HSA-203641	3.278645e-01	0.484
Regulation of PTEN localization	R-HSA-8948747	3.278645e-01	0.484
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	3.278645e-01	0.484
TRIF-mediated programmed cell death	R-HSA-2562578	3.278645e-01	0.484
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	3.278645e-01	0.484
Defective MMACHC causes MAHCC	R-HSA-3359474	4.439729e-01	0.353
Signaling by plasma membrane FGFR1 fusions	R-HSA-8853336	4.439729e-01	0.353
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	4.439729e-01	0.353
Invadopodia formation	R-HSA-8941237	4.439729e-01	0.353
Signalling to STAT3	R-HSA-198745	4.439729e-01	0.353
MET activates PTPN11	R-HSA-8865999	4.439729e-01	0.353
Activation of the pre-replicative complex	R-HSA-68962	1.352143e-01	0.869
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	1.610315e-01	0.793
TNFR1-induced proapoptotic signaling	R-HSA-5357786	1.933504e-01	0.714
Repression of WNT target genes	R-HSA-4641265	2.903036e-01	0.537
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	1.952029e-01	0.710
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	1.952029e-01	0.710
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	1.952029e-01	0.710
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	2.600532e-01	0.585
Type I hemidesmosome assembly	R-HSA-446107	3.700429e-01	0.432
Regulation of NPAS4 mRNA translation	R-HSA-9768778	3.700429e-01	0.432
Signaling by MRAS-complex mutants	R-HSA-9660537	3.700429e-01	0.432
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	3.700429e-01	0.432
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	2.348115e-01	0.629
HIV elongation arrest and recovery	R-HSA-167287	2.132296e-01	0.671
Pausing and recovery of HIV elongation	R-HSA-167290	2.132296e-01	0.671
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	3.220454e-01	0.492
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	3.220454e-01	0.492
DNA Damage Recognition in GG-NER	R-HSA-5696394	1.944634e-01	0.711
Signaling by ERBB2 ECD mutants	R-HSA-9665348	2.857495e-01	0.544
Ephrin signaling	R-HSA-3928664	2.857495e-01	0.544
Formation of RNA Pol II elongation complex	R-HSA-112382	1.734302e-01	0.761
Deadenylation of mRNA	R-HSA-429947	2.784570e-01	0.555
E2F mediated regulation of DNA replication	R-HSA-113510	3.117868e-01	0.506
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	3.117868e-01	0.506
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	3.538002e-01	0.451
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	4.111276e-01	0.386
Interleukin-21 signaling	R-HSA-9020958	4.111276e-01	0.386
Inactivation of CDC42 and RAC1	R-HSA-428543	4.111276e-01	0.386
ALK mutants bind TKIs	R-HSA-9700645	4.111276e-01	0.386
TNFR1-mediated ceramide production	R-HSA-5626978	5.055691e-01	0.296
PLCG1 events in ERBB2 signaling	R-HSA-1251932	5.055691e-01	0.296
Defective LFNG causes SCDO3	R-HSA-5083630	5.055691e-01	0.296
GRB7 events in ERBB2 signaling	R-HSA-1306955	5.055691e-01	0.296
Signaling by LRP5 mutants	R-HSA-5339717	5.055691e-01	0.296
RNA Polymerase II Transcription Elongation	R-HSA-75955	1.856730e-01	0.731
MAP2K and MAPK activation	R-HSA-5674135	2.222717e-01	0.653
EGFR downregulation	R-HSA-182971	2.703276e-01	0.568
Downstream signal transduction	R-HSA-186763	2.703276e-01	0.568
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.636232e-01	0.786
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	3.380263e-01	0.471
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	3.853605e-01	0.414
SHC1 events in EGFR signaling	R-HSA-180336	3.853605e-01	0.414
Centrosome maturation	R-HSA-380287	1.840882e-01	0.735
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	3.235336e-01	0.490
MET activates RAP1 and RAC1	R-HSA-8875555	4.508436e-01	0.346
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	4.508436e-01	0.346
Phosphorylation of the APC/C	R-HSA-176412	4.165443e-01	0.380
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	3.164255e-01	0.500
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	3.164255e-01	0.500
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	3.164255e-01	0.500
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	3.164255e-01	0.500
Meiotic synapsis	R-HSA-1221632	2.917202e-01	0.535
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	2.917202e-01	0.535
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	3.693169e-01	0.433
Formation of the Early Elongation Complex	R-HSA-113418	3.693169e-01	0.433
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	3.510747e-01	0.455
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	2.550393e-01	0.593
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	3.537279e-01	0.451
HIV Transcription Initiation	R-HSA-167161	3.537279e-01	0.451
RNA Polymerase II Transcription Initiation	R-HSA-75953	3.537279e-01	0.451
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	4.889901e-01	0.311
NOSIP mediated eNOS trafficking	R-HSA-203754	5.603449e-01	0.252
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	5.603449e-01	0.252
FLT3 signaling by CBL mutants	R-HSA-9706377	5.603449e-01	0.252
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	5.603449e-01	0.252
Interleukin receptor SHC signaling	R-HSA-912526	4.425341e-01	0.354
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	4.425341e-01	0.354
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	4.425341e-01	0.354
RNA Polymerase II Promoter Escape	R-HSA-73776	3.914192e-01	0.407
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	4.680143e-01	0.330
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	5.254274e-01	0.279
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	4.291386e-01	0.367
Nucleosome assembly	R-HSA-774815	4.291386e-01	0.367
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	4.291386e-01	0.367
Regulation of PTEN stability and activity	R-HSA-8948751	4.250881e-01	0.372
FOXO-mediated transcription of cell death genes	R-HSA-9614657	5.063748e-01	0.296
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	4.479029e-01	0.349
Polymerase switching on the C-strand of the telomere	R-HSA-174411	4.930571e-01	0.307
Inhibition of DNA recombination at telomere	R-HSA-9670095	4.740130e-01	0.324
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	4.665511e-01	0.331
Regulation of signaling by CBL	R-HSA-912631	5.347017e-01	0.272
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	5.347017e-01	0.272
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	5.600662e-01	0.252
GRB2 events in EGFR signaling	R-HSA-179812	5.600662e-01	0.252
Scavenging by Class F Receptors	R-HSA-3000484	5.600662e-01	0.252
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	5.446914e-01	0.264
Orc1 removal from chromatin	R-HSA-68949	5.568408e-01	0.254
PPARA activates gene expression	R-HSA-1989781	5.572207e-01	0.254
SHC-mediated cascade:FGFR3	R-HSA-5654704	5.884587e-01	0.230
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	5.884587e-01	0.230
Signaling by Erythropoietin	R-HSA-9006335	5.875555e-01	0.231
Impaired BRCA2 binding to RAD51	R-HSA-9709570	5.875555e-01	0.231
Degradation of AXIN	R-HSA-4641257	5.881099e-01	0.231
Transcription of the HIV genome	R-HSA-167172	4.020375e-01	0.396
Signaling by EGFR in Cancer	R-HSA-1643713	5.175905e-01	0.286
Signaling by ERBB2 in Cancer	R-HSA-1227990	4.151377e-01	0.382
Signaling by MET	R-HSA-6806834	3.409179e-01	0.467
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	3.643375e-01	0.438
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	3.643375e-01	0.438
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	5.776585e-01	0.238
PI3K/AKT Signaling in Cancer	R-HSA-2219528	3.836413e-01	0.416
Interleukin-6 signaling	R-HSA-1059683	1.419303e-01	0.848
Chromosome Maintenance	R-HSA-73886	2.441625e-01	0.612
Signaling by EGFRvIII in Cancer	R-HSA-5637812	2.600532e-01	0.585
Constitutive Signaling by EGFRvIII	R-HSA-5637810	2.600532e-01	0.585
IGF1R signaling cascade	R-HSA-2428924	3.404606e-01	0.468
Processing of DNA double-strand break ends	R-HSA-5693607	4.727170e-01	0.325
Signaling by EGFR	R-HSA-177929	2.245861e-01	0.649
HIV Transcription Elongation	R-HSA-167169	3.164255e-01	0.500
VEGFR2 mediated vascular permeability	R-HSA-5218920	4.940133e-01	0.306
Extension of Telomeres	R-HSA-180786	5.281200e-01	0.277
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	5.800290e-01	0.237
Regulation of mitotic cell cycle	R-HSA-453276	5.800290e-01	0.237
RNA Polymerase III Transcription Initiation	R-HSA-76046	2.508564e-01	0.601
Listeria monocytogenes entry into host cells	R-HSA-8876384	3.905988e-01	0.408
Nucleotide Excision Repair	R-HSA-5696398	2.206760e-01	0.656
HCMV Early Events	R-HSA-9609690	5.458042e-01	0.263
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	1.195366e-01	0.922
EPH-Ephrin signaling	R-HSA-2682334	5.355143e-01	0.271
mRNA Capping	R-HSA-72086	5.875555e-01	0.231
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	1.450015e-01	0.839
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	2.600532e-01	0.585
VxPx cargo-targeting to cilium	R-HSA-5620916	3.380263e-01	0.471
Switching of origins to a post-replicative state	R-HSA-69052	2.483467e-01	0.605
Telomere Extension By Telomerase	R-HSA-171319	3.693169e-01	0.433
p75NTR recruits signalling complexes	R-HSA-209543	2.903036e-01	0.537
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	1.636338e-01	0.786
Synthesis of DNA	R-HSA-69239	5.324279e-01	0.274
Regulation of endogenous retroelements	R-HSA-9842860	5.659467e-01	0.247
Signaling by ERBB2 KD Mutants	R-HSA-9664565	5.875555e-01	0.231
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	3.164255e-01	0.500
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	2.245861e-01	0.649
Signaling by RAF1 mutants	R-HSA-9656223	2.222717e-01	0.653
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	4.771747e-01	0.321
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	2.890438e-01	0.539
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	4.378722e-01	0.359
TRAF6 mediated IRF7 activation	R-HSA-933541	5.881099e-01	0.231
DNA Replication Pre-Initiation	R-HSA-69002	4.510113e-01	0.346
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	3.557418e-01	0.449
EGFR Transactivation by Gastrin	R-HSA-2179392	1.976090e-01	0.704
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	3.220454e-01	0.492
DNA Double Strand Break Response	R-HSA-5693606	1.778048e-01	0.750
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	2.620347e-01	0.582
Signaling by BMP	R-HSA-201451	5.415521e-01	0.266
Activation of the AP-1 family of transcription factors	R-HSA-450341	1.684904e-01	0.773
Signaling by Activin	R-HSA-1502540	1.864919e-01	0.729
Co-inhibition by CTLA4	R-HSA-389513	3.380263e-01	0.471
G-protein beta:gamma signalling	R-HSA-397795	3.102583e-01	0.508
Regulation of CDH11 function	R-HSA-9762292	4.508436e-01	0.346
PI3K/AKT activation	R-HSA-198203	4.508436e-01	0.346
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	2.980383e-01	0.526
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	1.866985e-01	0.729
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	3.905988e-01	0.408
LGI-ADAM interactions	R-HSA-5682910	4.889901e-01	0.311
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	3.725480e-01	0.429
Chaperone Mediated Autophagy	R-HSA-9613829	5.063748e-01	0.296
Assembly of the pre-replicative complex	R-HSA-68867	5.489454e-01	0.260
Homology Directed Repair	R-HSA-5693538	3.836413e-01	0.416
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	1.214511e-01	0.916
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	1.636602e-01	0.786
GP1b-IX-V activation signalling	R-HSA-430116	4.111276e-01	0.386
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	5.261381e-01	0.279
CD28 dependent PI3K/Akt signaling	R-HSA-389357	5.415521e-01	0.266
DNA Double-Strand Break Repair	R-HSA-5693532	2.161657e-01	0.665
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	2.445157e-01	0.612
p75NTR signals via NF-kB	R-HSA-193639	3.853605e-01	0.414
Mismatch Repair	R-HSA-5358508	2.857495e-01	0.544
Cyclin D associated events in G1	R-HSA-69231	1.632733e-01	0.787
G1 Phase	R-HSA-69236	1.632733e-01	0.787
RNA Polymerase III Transcription	R-HSA-74158	2.445157e-01	0.612
Signaling by Hedgehog	R-HSA-5358351	2.132754e-01	0.671
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	1.214511e-01	0.916
Trafficking of AMPA receptors	R-HSA-399719	1.491047e-01	0.827
Adrenoceptors	R-HSA-390696	3.700429e-01	0.432
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	1.787663e-01	0.748
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	2.564086e-01	0.591
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	4.111276e-01	0.386
Regulation of gap junction activity	R-HSA-191650	5.055691e-01	0.296
Telomere C-strand synthesis initiation	R-HSA-174430	3.853605e-01	0.414
Separation of Sister Chromatids	R-HSA-2467813	1.818166e-01	0.740
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	4.425341e-01	0.354
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	4.425511e-01	0.354
DARPP-32 events	R-HSA-180024	5.875555e-01	0.231
VEGFA-VEGFR2 Pathway	R-HSA-4420097	1.897630e-01	0.722
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	5.128643e-01	0.290
Signaling by FGFR1 in disease	R-HSA-5655302	2.222717e-01	0.653
Clathrin-mediated endocytosis	R-HSA-8856828	1.441334e-01	0.841
Downstream signaling of activated FGFR3	R-HSA-5654708	5.875555e-01	0.231
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	3.553728e-01	0.449
Intracellular signaling by second messengers	R-HSA-9006925	1.390071e-01	0.857
UCH proteinases	R-HSA-5689603	1.249029e-01	0.903
Protein-protein interactions at synapses	R-HSA-6794362	2.103813e-01	0.677
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.391372e-01	0.857
Activation of HOX genes during differentiation	R-HSA-5619507	3.886675e-01	0.410
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	3.886675e-01	0.410
FOXO-mediated transcription	R-HSA-9614085	5.273834e-01	0.278
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	5.600662e-01	0.252
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	5.800290e-01	0.237
Signaling by PDGF	R-HSA-186797	5.771019e-01	0.239
Signaling by FGFR4	R-HSA-5654743	5.522952e-01	0.258
RNA Polymerase II Pre-transcription Events	R-HSA-674695	1.737064e-01	0.760
Signalling to RAS	R-HSA-167044	3.643375e-01	0.438
Cilium Assembly	R-HSA-5617833	2.661231e-01	0.575
Frs2-mediated activation	R-HSA-170968	1.419303e-01	0.848
Signaling by VEGF	R-HSA-194138	2.937926e-01	0.532
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	1.989733e-01	0.701
Post-transcriptional silencing by small RNAs	R-HSA-426496	1.989733e-01	0.701
Regulation of TP53 Activity through Methylation	R-HSA-6804760	1.368789e-01	0.864
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	1.368789e-01	0.864
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	1.297451e-01	0.887
Signaling by NODAL	R-HSA-1181150	1.736740e-01	0.760
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	2.348435e-01	0.629
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.508018e-01	0.822
RAF-independent MAPK1/3 activation	R-HSA-112409	2.348115e-01	0.629
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	2.212109e-01	0.655
PTK6 Activates STAT3	R-HSA-8849474	5.603449e-01	0.252
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	5.603449e-01	0.252
Activation of AKT2	R-HSA-165158	5.603449e-01	0.252
G2/M DNA damage checkpoint	R-HSA-69473	3.699485e-01	0.432
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	5.884587e-01	0.230
MAPK6/MAPK4 signaling	R-HSA-5687128	4.106002e-01	0.387
Pre-NOTCH Transcription and Translation	R-HSA-1912408	5.082801e-01	0.294
Downregulation of ERBB2 signaling	R-HSA-8863795	1.352143e-01	0.869
Recycling pathway of L1	R-HSA-437239	4.665511e-01	0.331
Late Phase of HIV Life Cycle	R-HSA-162599	1.378053e-01	0.861
FGFR1 mutant receptor activation	R-HSA-1839124	3.102583e-01	0.508
Signaling by TGF-beta Receptor Complex	R-HSA-170834	2.917959e-01	0.535
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	2.588076e-01	0.587
Signaling by WNT	R-HSA-195721	1.194706e-01	0.923
Signaling by TGFB family members	R-HSA-9006936	2.096162e-01	0.679
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.696556e-01	0.770
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	2.807688e-01	0.552
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	2.807688e-01	0.552
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	2.807688e-01	0.552
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	2.807688e-01	0.552
Pexophagy	R-HSA-9664873	1.976090e-01	0.704
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.223857e-01	0.912
Signaling by FLT3 fusion proteins	R-HSA-9703465	1.777838e-01	0.750
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	5.771019e-01	0.239
MAPK family signaling cascades	R-HSA-5683057	2.926690e-01	0.534
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	1.572528e-01	0.803
Regulation of localization of FOXO transcription factors	R-HSA-9614399	2.278156e-01	0.642
Nef Mediated CD4 Down-regulation	R-HSA-167590	3.278645e-01	0.484
Inhibition of nitric oxide production	R-HSA-9636249	4.439729e-01	0.353
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	2.348115e-01	0.629
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	5.055691e-01	0.296
Transcriptional activation of p53 responsive genes	R-HSA-69560	5.055691e-01	0.296
HDACs deacetylate histones	R-HSA-3214815	2.112710e-01	0.675
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	4.508436e-01	0.346
Rab regulation of trafficking	R-HSA-9007101	1.458400e-01	0.836
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	4.165443e-01	0.380
Deadenylation-dependent mRNA decay	R-HSA-429914	3.884019e-01	0.411
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	5.254274e-01	0.279
Oxidative Stress Induced Senescence	R-HSA-2559580	4.559176e-01	0.341
MAPK1/MAPK3 signaling	R-HSA-5684996	4.622894e-01	0.335
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	3.252970e-01	0.488
Signaling by PTK6	R-HSA-8848021	3.252970e-01	0.488
Evasion by RSV of host interferon responses	R-HSA-9833109	2.703276e-01	0.568
Nervous system development	R-HSA-9675108	4.102243e-01	0.387
Ub-specific processing proteases	R-HSA-5689880	1.973189e-01	0.705
Axon guidance	R-HSA-422475	3.446648e-01	0.463
Neurofascin interactions	R-HSA-447043	2.849570e-01	0.545
Regulation of CDH11 Expression and Function	R-HSA-9759475	1.219944e-01	0.914
Vasopressin-like receptors	R-HSA-388479	5.055691e-01	0.296
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	5.254274e-01	0.279
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	4.940133e-01	0.306
Signaling by NOTCH	R-HSA-157118	4.893802e-01	0.310
Signaling by ALK in cancer	R-HSA-9700206	1.696556e-01	0.770
Interleukin-6 family signaling	R-HSA-6783589	4.680143e-01	0.330
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	3.278645e-01	0.484
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	2.570739e-01	0.590
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	4.771747e-01	0.321
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	5.347017e-01	0.272
RNA Polymerase II Transcription	R-HSA-73857	1.448729e-01	0.839
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	3.042269e-01	0.517
RAF/MAP kinase cascade	R-HSA-5673001	5.406269e-01	0.267
Organelle biogenesis and maintenance	R-HSA-1852241	2.275192e-01	0.643
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	2.348435e-01	0.629
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	1.980714e-01	0.703
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	5.063748e-01	0.296
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	2.168343e-01	0.664
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	3.042269e-01	0.517
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	3.367234e-01	0.473
Negative regulation of MAPK pathway	R-HSA-5675221	2.222717e-01	0.653
TP53 Regulates Metabolic Genes	R-HSA-5628897	5.371478e-01	0.270
Generic Transcription Pathway	R-HSA-212436	4.381541e-01	0.358
Interleukin-2 family signaling	R-HSA-451927	1.922701e-01	0.716
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	3.367234e-01	0.473
Regulation of CDH1 Gene Transcription	R-HSA-9764560	2.118152e-01	0.674
Selective autophagy	R-HSA-9663891	5.856479e-01	0.232
MTOR signalling	R-HSA-165159	3.725480e-01	0.429
Resolution of Abasic Sites (AP sites)	R-HSA-73933	3.350046e-01	0.475
Formation of editosomes by ADAR proteins	R-HSA-77042	2.092342e-01	0.679
AKT-mediated inactivation of FOXO1A	R-HSA-211163	1.572528e-01	0.803
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	2.968191e-01	0.528
NrCAM interactions	R-HSA-447038	1.989733e-01	0.701
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	1.989733e-01	0.701
mRNA Editing: A to I Conversion	R-HSA-75064	3.747077e-01	0.426
TGFBR3 regulates activin signaling	R-HSA-9839406	3.747077e-01	0.426
C6 deamination of adenosine	R-HSA-75102	3.747077e-01	0.426
CREB phosphorylation	R-HSA-199920	2.849570e-01	0.545
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	1.864919e-01	0.729
Regulation of gene expression in beta cells	R-HSA-210745	1.219944e-01	0.914
Neurodegenerative Diseases	R-HSA-8863678	1.450015e-01	0.839
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.450015e-01	0.839
Negative regulation of FLT3	R-HSA-9706369	2.102716e-01	0.677
Myogenesis	R-HSA-525793	1.777838e-01	0.750
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	3.700429e-01	0.432
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	2.857495e-01	0.544
Unwinding of DNA	R-HSA-176974	4.111276e-01	0.386
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	5.055691e-01	0.296
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	5.055691e-01	0.296
TBC/RABGAPs	R-HSA-8854214	2.538520e-01	0.595
Metalloprotease DUBs	R-HSA-5689901	3.235336e-01	0.490
G2/M Checkpoints	R-HSA-69481	1.196085e-01	0.922
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	4.508436e-01	0.346
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	4.471938e-01	0.350
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	5.603449e-01	0.252
Reelin signalling pathway	R-HSA-8866376	5.603449e-01	0.252
Regulation of FZD by ubiquitination	R-HSA-4641263	4.771747e-01	0.321
NF-kB is activated and signals survival	R-HSA-209560	5.254274e-01	0.279
PKA activation in glucagon signalling	R-HSA-164378	5.063748e-01	0.296
Golgi-to-ER retrograde transport	R-HSA-8856688	3.788009e-01	0.422
Signaling by FGFR2 IIIa TM	R-HSA-8851708	5.347017e-01	0.272
VLDLR internalisation and degradation	R-HSA-8866427	5.600662e-01	0.252
Cellular response to hypoxia	R-HSA-1234174	4.863984e-01	0.313
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	5.261381e-01	0.279
RNA Polymerase I Transcription Initiation	R-HSA-73762	5.331908e-01	0.273
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	5.392799e-01	0.268
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	5.446914e-01	0.264
PCP/CE pathway	R-HSA-4086400	5.541086e-01	0.256
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	2.398053e-01	0.620
Membrane Trafficking	R-HSA-199991	2.789966e-01	0.554
Signaling by FGFR in disease	R-HSA-1226099	3.699485e-01	0.432
ESR-mediated signaling	R-HSA-8939211	2.097803e-01	0.678
MyD88 dependent cascade initiated on endosome	R-HSA-975155	3.504244e-01	0.455
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	5.261381e-01	0.279
MyD88 cascade initiated on plasma membrane	R-HSA-975871	2.177594e-01	0.662
Diseases of DNA repair	R-HSA-9675135	3.035487e-01	0.518
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	3.386651e-01	0.470
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	2.177594e-01	0.662
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	2.177594e-01	0.662
L1CAM interactions	R-HSA-373760	4.584288e-01	0.339
Signaling by NOTCH1	R-HSA-1980143	2.869741e-01	0.542
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.952029e-01	0.710
Signal transduction by L1	R-HSA-445144	1.736740e-01	0.760
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	2.538520e-01	0.595
HIV Life Cycle	R-HSA-162587	1.366325e-01	0.864
FLT3 signaling in disease	R-HSA-9682385	2.445157e-01	0.612
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	2.747153e-01	0.561
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	1.955285e-01	0.709
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	3.377388e-01	0.471
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	2.348115e-01	0.629
Receptor Mediated Mitophagy	R-HSA-8934903	4.508436e-01	0.346
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	3.981367e-01	0.400
MyD88-independent TLR4 cascade	R-HSA-166166	1.955285e-01	0.709
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	1.534677e-01	0.814
Signaling by PDGFR in disease	R-HSA-9671555	2.137605e-01	0.670
Toll-like Receptor Cascades	R-HSA-168898	5.797069e-01	0.237
Signaling by Nuclear Receptors	R-HSA-9006931	3.988990e-01	0.399
Activation of PUMA and translocation to mitochondria	R-HSA-139915	3.278645e-01	0.484
Formation of intermediate mesoderm	R-HSA-9761174	4.508436e-01	0.346
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	3.720266e-01	0.429
HIV Infection	R-HSA-162906	3.781655e-01	0.422
NOD1/2 Signaling Pathway	R-HSA-168638	5.261381e-01	0.279
G alpha (z) signalling events	R-HSA-418597	3.234065e-01	0.490
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	2.903036e-01	0.537
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	4.111276e-01	0.386
Regulation of TP53 Expression and Degradation	R-HSA-6806003	1.779457e-01	0.750
Signaling by Leptin	R-HSA-2586552	1.976090e-01	0.704
CD209 (DC-SIGN) signaling	R-HSA-5621575	4.680143e-01	0.330
G1/S DNA Damage Checkpoints	R-HSA-69615	4.539638e-01	0.343
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	5.033540e-01	0.298
p53-Dependent G1 DNA Damage Response	R-HSA-69563	5.033540e-01	0.298
SARS-CoV-2-host interactions	R-HSA-9705683	3.188445e-01	0.496
Tie2 Signaling	R-HSA-210993	2.857495e-01	0.544
HDMs demethylate histones	R-HSA-3214842	1.610315e-01	0.793
Zygotic genome activation (ZGA)	R-HSA-9819196	3.643375e-01	0.438
Programmed Cell Death	R-HSA-5357801	4.801141e-01	0.319
PI Metabolism	R-HSA-1483255	1.832229e-01	0.737
MHC class II antigen presentation	R-HSA-2132295	3.477384e-01	0.459
Negative feedback regulation of MAPK pathway	R-HSA-5674499	2.417929e-01	0.617
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	1.787663e-01	0.748
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	1.787663e-01	0.748
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	5.055691e-01	0.296
Signaling by NOTCH1 in Cancer	R-HSA-2644603	2.807688e-01	0.552
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	4.471938e-01	0.350
Synthesis of PI	R-HSA-1483226	4.889901e-01	0.311
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	5.603449e-01	0.252
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	5.254274e-01	0.279
Mitochondrial biogenesis	R-HSA-1592230	3.720708e-01	0.429
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	4.139998e-01	0.383
Effects of PIP2 hydrolysis	R-HSA-114508	5.045849e-01	0.297
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	5.568408e-01	0.254
Signaling by NTRK3 (TRKC)	R-HSA-9034015	3.905988e-01	0.408
Interleukin-7 signaling	R-HSA-1266695	4.930571e-01	0.307
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.407790e-01	0.851
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.684904e-01	0.773
Cell-extracellular matrix interactions	R-HSA-446353	1.864919e-01	0.729
Signaling by NOTCH4	R-HSA-9013694	2.610121e-01	0.583
Regulation of TP53 Degradation	R-HSA-6804757	3.922766e-01	0.406
Apoptosis	R-HSA-109581	2.251949e-01	0.647
Regulation of CDH11 gene transcription	R-HSA-9762293	1.684904e-01	0.773
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	2.849570e-01	0.545
Regulation of NFE2L2 gene expression	R-HSA-9818749	2.849570e-01	0.545
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	3.853605e-01	0.414
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	2.842769e-01	0.546
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	1.695842e-01	0.771
RMTs methylate histone arginines	R-HSA-3214858	5.710341e-01	0.243
Transcriptional regulation by RUNX2	R-HSA-8878166	4.944137e-01	0.306
Regulation of beta-cell development	R-HSA-186712	1.703972e-01	0.769
Specification of primordial germ cells	R-HSA-9827857	1.199254e-01	0.921
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	4.943569e-01	0.306
Host Interactions of HIV factors	R-HSA-162909	2.735359e-01	0.563
MITF-M-regulated melanocyte development	R-HSA-9730414	3.298230e-01	0.482
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	2.102716e-01	0.677
MECP2 regulates transcription factors	R-HSA-9022707	3.278645e-01	0.484
Uptake and function of anthrax toxins	R-HSA-5210891	2.600532e-01	0.585
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	4.111276e-01	0.386
Dopamine receptors	R-HSA-390651	5.055691e-01	0.296
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	5.603449e-01	0.252
SMAC (DIABLO) binds to IAPs	R-HSA-111463	5.603449e-01	0.252
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	5.603449e-01	0.252
Anchoring fibril formation	R-HSA-2214320	5.254274e-01	0.279
MITF-M-dependent gene expression	R-HSA-9856651	1.403249e-01	0.853
Formation of paraxial mesoderm	R-HSA-9793380	4.212272e-01	0.375
Signaling by NTRK2 (TRKB)	R-HSA-9006115	5.415521e-01	0.266
Netrin-1 signaling	R-HSA-373752	1.632733e-01	0.787
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	4.165443e-01	0.380
Other interleukin signaling	R-HSA-449836	5.347017e-01	0.272
Sensory processing of sound	R-HSA-9659379	4.434279e-01	0.353
Nephrin family interactions	R-HSA-373753	5.620819e-01	0.250
Gene Silencing by RNA	R-HSA-211000	1.696556e-01	0.770
Activation of ATR in response to replication stress	R-HSA-176187	3.102583e-01	0.508
Glycolysis	R-HSA-70171	2.382692e-01	0.623
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	3.272256e-01	0.485
Interleukin-2 signaling	R-HSA-9020558	4.889901e-01	0.311
Pervasive developmental disorders	R-HSA-9005895	2.903036e-01	0.537
Disorders of Nervous System Development	R-HSA-9697154	2.903036e-01	0.537
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	2.903036e-01	0.537
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.662350e-01	0.779
Physiological factors	R-HSA-5578768	3.538002e-01	0.451
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	5.175905e-01	0.286
Glucose metabolism	R-HSA-70326	4.704611e-01	0.327
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	4.889901e-01	0.311
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	5.603449e-01	0.252
tRNA processing	R-HSA-72306	4.592027e-01	0.338
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	5.063748e-01	0.296
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	4.772155e-01	0.321
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	5.710341e-01	0.243
Signaling by FGFR3	R-HSA-5654741	5.893797e-01	0.230
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	5.893797e-01	0.230
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	5.893797e-01	0.230
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	5.893797e-01	0.230
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	5.909664e-01	0.228
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	5.928578e-01	0.227
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	5.928578e-01	0.227
PI5P Regulates TP53 Acetylation	R-HSA-6811555	5.928578e-01	0.227
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	5.928578e-01	0.227
RSV-host interactions	R-HSA-9833110	6.032391e-01	0.220
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	6.077551e-01	0.216
Insulin receptor signalling cascade	R-HSA-74751	6.084062e-01	0.216
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	6.090552e-01	0.215
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	6.090552e-01	0.215
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	6.090552e-01	0.215
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	6.090552e-01	0.215
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	6.090552e-01	0.215
Phosphorylation of Emi1	R-HSA-176417	6.090552e-01	0.215
Defective CSF2RA causes SMDP4	R-HSA-5688890	6.090552e-01	0.215
Defective CSF2RB causes SMDP5	R-HSA-5688849	6.090552e-01	0.215
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	6.090552e-01	0.215
Ligand-receptor interactions	R-HSA-5632681	6.090552e-01	0.215
Pentose phosphate pathway disease	R-HSA-6791465	6.090552e-01	0.215
Synthesis of PS	R-HSA-1483101	6.090552e-01	0.215
CDC6 association with the ORC:origin complex	R-HSA-68689	6.090552e-01	0.215
Noncanonical activation of NOTCH3	R-HSA-9017802	6.090552e-01	0.215
Release of Hh-Np from the secreting cell	R-HSA-5362798	6.090552e-01	0.215
Diseases of Base Excision Repair	R-HSA-9605308	6.090552e-01	0.215
Relaxin receptors	R-HSA-444821	6.090552e-01	0.215
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	6.090552e-01	0.215
Aryl hydrocarbon receptor signalling	R-HSA-8937144	6.090552e-01	0.215
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	6.090552e-01	0.215
Signaling by ROBO receptors	R-HSA-376176	6.093322e-01	0.215
Downstream signaling of activated FGFR4	R-HSA-5654716	6.095163e-01	0.215
DAP12 signaling	R-HSA-2424491	6.095163e-01	0.215
Activation of BH3-only proteins	R-HSA-114452	6.095163e-01	0.215
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	6.107904e-01	0.214
Telomere Maintenance	R-HSA-157579	6.137497e-01	0.212
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	6.137907e-01	0.212
SHC-mediated cascade:FGFR4	R-HSA-5654719	6.137907e-01	0.212
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	6.137907e-01	0.212
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	6.137907e-01	0.212
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	6.137907e-01	0.212
Interleukin-1 family signaling	R-HSA-446652	6.154654e-01	0.211
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	6.199548e-01	0.208
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	6.237863e-01	0.205
Signaling by FGFR4 in disease	R-HSA-5655291	6.237863e-01	0.205
NRIF signals cell death from the nucleus	R-HSA-205043	6.237863e-01	0.205
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	6.237863e-01	0.205
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	6.237863e-01	0.205
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	6.238460e-01	0.205
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	6.247964e-01	0.204
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	6.249744e-01	0.204
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	6.268486e-01	0.203
Cargo concentration in the ER	R-HSA-5694530	6.307424e-01	0.200
Negative regulation of the PI3K/AKT network	R-HSA-199418	6.310534e-01	0.200
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	6.324170e-01	0.199
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	6.377491e-01	0.195
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	6.378868e-01	0.195
FGFR2 alternative splicing	R-HSA-6803529	6.380497e-01	0.195
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	6.380497e-01	0.195
LDL clearance	R-HSA-8964038	6.380497e-01	0.195
IRS-mediated signalling	R-HSA-112399	6.396917e-01	0.194
GPER1 signaling	R-HSA-9634597	6.418283e-01	0.193
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	6.418283e-01	0.193
Co-stimulation by CD28	R-HSA-389356	6.418283e-01	0.193
Regulation of RUNX3 expression and activity	R-HSA-8941858	6.453698e-01	0.190
Formation of Incision Complex in GG-NER	R-HSA-5696395	6.453698e-01	0.190
Negative regulation of NOTCH4 signaling	R-HSA-9604323	6.453698e-01	0.190
Signaling by Interleukins	R-HSA-449147	6.457501e-01	0.190
Meiosis	R-HSA-1500620	6.508447e-01	0.187
DNA strand elongation	R-HSA-69190	6.512119e-01	0.186
PTK6 promotes HIF1A stabilization	R-HSA-8857538	6.523713e-01	0.186
Signaling by LTK in cancer	R-HSA-9842640	6.523713e-01	0.186
Erythropoietin activates STAT5	R-HSA-9027283	6.523713e-01	0.186
STAT5 Activation	R-HSA-9645135	6.523713e-01	0.186
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	6.523713e-01	0.186
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	6.523713e-01	0.186
Defective CHST14 causes EDS, musculocontractural type	R-HSA-3595174	6.523713e-01	0.186
MET Receptor Activation	R-HSA-6806942	6.523713e-01	0.186
CREB3 factors activate genes	R-HSA-8874211	6.523713e-01	0.186
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	6.528619e-01	0.185
Processive synthesis on the lagging strand	R-HSA-69183	6.528619e-01	0.185
IRF3-mediated induction of type I IFN	R-HSA-3270619	6.528619e-01	0.185
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	6.528619e-01	0.185
Spry regulation of FGF signaling	R-HSA-1295596	6.528619e-01	0.185
Sema3A PAK dependent Axon repulsion	R-HSA-399954	6.528619e-01	0.185
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	6.528619e-01	0.185
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	6.528619e-01	0.185
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	6.528619e-01	0.185
p38MAPK events	R-HSA-171007	6.528619e-01	0.185
Activation of BAD and translocation to mitochondria	R-HSA-111447	6.528619e-01	0.185
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	6.528619e-01	0.185
HDR through Homologous Recombination (HRR)	R-HSA-5685942	6.530106e-01	0.185
Regulation of PTEN mRNA translation	R-HSA-8943723	6.612196e-01	0.180
Syndecan interactions	R-HSA-3000170	6.612196e-01	0.180
Growth hormone receptor signaling	R-HSA-982772	6.612196e-01	0.180
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	6.633027e-01	0.178
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	6.709095e-01	0.173
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	6.724326e-01	0.172
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	6.724326e-01	0.172
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	6.724326e-01	0.172
Regulation of RAS by GAPs	R-HSA-5658442	6.744634e-01	0.171
PI3K Cascade	R-HSA-109704	6.744634e-01	0.171
XBP1(S) activates chaperone genes	R-HSA-381038	6.762254e-01	0.170
Nuclear Receptor transcription pathway	R-HSA-383280	6.782588e-01	0.169
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	6.801155e-01	0.167
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	6.801155e-01	0.167
Degradation of GLI1 by the proteasome	R-HSA-5610780	6.806350e-01	0.167
Degradation of GLI2 by the proteasome	R-HSA-5610783	6.806350e-01	0.167
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	6.806350e-01	0.167
SHC-mediated cascade:FGFR1	R-HSA-5654688	6.832946e-01	0.165
TRAF6 mediated NF-kB activation	R-HSA-933542	6.832946e-01	0.165
Chaperonin-mediated protein folding	R-HSA-390466	6.884964e-01	0.162
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	6.898260e-01	0.161
Miscellaneous transport and binding events	R-HSA-5223345	6.898260e-01	0.161
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	6.908903e-01	0.161
MET activates PI3K/AKT signaling	R-HSA-8851907	6.908903e-01	0.161
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	6.908903e-01	0.161
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	6.908903e-01	0.161
DAG1 core M1 glycosylations	R-HSA-8932506	6.908903e-01	0.161
Recycling of eIF2:GDP	R-HSA-72731	6.908903e-01	0.161
PTK6 Expression	R-HSA-8849473	6.908903e-01	0.161
Synthesis of PIPs in the nucleus	R-HSA-8847453	6.908903e-01	0.161
Activated NTRK3 signals through PI3K	R-HSA-9603381	6.908903e-01	0.161
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	6.908903e-01	0.161
VLDL clearance	R-HSA-8964046	6.908903e-01	0.161
CHL1 interactions	R-HSA-447041	6.908903e-01	0.161
COPII-mediated vesicle transport	R-HSA-204005	6.945116e-01	0.158
Depyrimidination	R-HSA-73928	6.973583e-01	0.157
Cleavage of the damaged pyrimidine	R-HSA-110329	6.973583e-01	0.157
IRS-related events triggered by IGF1R	R-HSA-2428928	6.990433e-01	0.155
Diseases of programmed cell death	R-HSA-9645723	7.004801e-01	0.155
Signaling by FGFR2	R-HSA-5654738	7.036015e-01	0.153
Sema4D in semaphorin signaling	R-HSA-400685	7.042781e-01	0.152
Long-term potentiation	R-HSA-9620244	7.042781e-01	0.152
VEGFR2 mediated cell proliferation	R-HSA-5218921	7.042781e-01	0.152
MicroRNA (miRNA) biogenesis	R-HSA-203927	7.042781e-01	0.152
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	7.051255e-01	0.152
Pre-NOTCH Expression and Processing	R-HSA-1912422	7.051738e-01	0.152
GRB2 events in ERBB2 signaling	R-HSA-1963640	7.055940e-01	0.151
SHC1 events in ERBB4 signaling	R-HSA-1250347	7.055940e-01	0.151
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	7.055940e-01	0.151
Transcriptional regulation of testis differentiation	R-HSA-9690406	7.055940e-01	0.151
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	7.055940e-01	0.151
Acetylcholine regulates insulin secretion	R-HSA-399997	7.055940e-01	0.151
Fibronectin matrix formation	R-HSA-1566977	7.055940e-01	0.151
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	7.055940e-01	0.151
Cargo trafficking to the periciliary membrane	R-HSA-5620920	7.076175e-01	0.150
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	7.079572e-01	0.150
Mitophagy	R-HSA-5205647	7.079572e-01	0.150
DNA Replication	R-HSA-69306	7.095060e-01	0.149
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	7.128310e-01	0.147
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	7.197007e-01	0.143
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	7.241809e-01	0.140
TRP channels	R-HSA-3295583	7.241809e-01	0.140
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	7.241809e-01	0.140
ALKBH3 mediated reversal of alkylation damage	R-HSA-112126	7.251432e-01	0.140
EGFR interacts with phospholipase C-gamma	R-HSA-212718	7.251432e-01	0.140
DAG1 core M2 glycosylations	R-HSA-8932504	7.251432e-01	0.140
MET receptor recycling	R-HSA-8875656	7.251432e-01	0.140
Myoclonic epilepsy of Lafora	R-HSA-3785653	7.251432e-01	0.140
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	7.251432e-01	0.140
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	7.251432e-01	0.140
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	7.251432e-01	0.140
Interleukin-23 signaling	R-HSA-9020933	7.251432e-01	0.140
Regulation by c-FLIP	R-HSA-3371378	7.251432e-01	0.140
Co-stimulation by ICOS	R-HSA-9927354	7.251432e-01	0.140
Formation of annular gap junctions	R-HSA-196025	7.251432e-01	0.140
ROBO receptors bind AKAP5	R-HSA-9010642	7.251432e-01	0.140
Interleukin-9 signaling	R-HSA-8985947	7.251432e-01	0.140
TGFBR3 PTM regulation	R-HSA-9839383	7.251432e-01	0.140
Dimerization of procaspase-8	R-HSA-69416	7.251432e-01	0.140
Alpha-defensins	R-HSA-1462054	7.251432e-01	0.140
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	7.251432e-01	0.140
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	7.253039e-01	0.139
Downstream signaling of activated FGFR2	R-HSA-5654696	7.253039e-01	0.139
Downstream signaling of activated FGFR1	R-HSA-5654687	7.253039e-01	0.139
Oncogene Induced Senescence	R-HSA-2559585	7.253039e-01	0.139
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	7.253039e-01	0.139
Semaphorin interactions	R-HSA-373755	7.261881e-01	0.139
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	7.261881e-01	0.139
Influenza Viral RNA Transcription and Replication	R-HSA-168273	7.268881e-01	0.139
SARS-CoV-1-host interactions	R-HSA-9692914	7.279807e-01	0.138
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	7.289605e-01	0.137
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	7.293559e-01	0.137
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	7.293559e-01	0.137
Regulation of NPAS4 gene expression	R-HSA-9768759	7.293559e-01	0.137
Reproduction	R-HSA-1474165	7.310206e-01	0.136
Regulation of CDH1 Expression and Function	R-HSA-9764265	7.332790e-01	0.135
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	7.332790e-01	0.135
Base-Excision Repair, AP Site Formation	R-HSA-73929	7.337680e-01	0.134
Adherens junctions interactions	R-HSA-418990	7.378847e-01	0.132
Cytoprotection by HMOX1	R-HSA-9707564	7.391520e-01	0.131
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	7.418709e-01	0.130
Calmodulin induced events	R-HSA-111933	7.418709e-01	0.130
CaM pathway	R-HSA-111997	7.418709e-01	0.130
Processive synthesis on the C-strand of the telomere	R-HSA-174414	7.430206e-01	0.129
SHC-mediated cascade:FGFR2	R-HSA-5654699	7.430206e-01	0.129
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	7.430206e-01	0.129
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	7.430206e-01	0.129
Asymmetric localization of PCP proteins	R-HSA-4608870	7.438387e-01	0.129
Somitogenesis	R-HSA-9824272	7.438387e-01	0.129
DAG and IP3 signaling	R-HSA-1489509	7.438387e-01	0.129
IRE1alpha activates chaperones	R-HSA-381070	7.454614e-01	0.128
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	7.473270e-01	0.126
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	7.514687e-01	0.124
Synaptic adhesion-like molecules	R-HSA-8849932	7.514687e-01	0.124
Nephron development	R-HSA-9831926	7.514687e-01	0.124
Macroautophagy	R-HSA-1632852	7.553943e-01	0.122
ARMS-mediated activation	R-HSA-170984	7.556022e-01	0.122
CASP8 activity is inhibited	R-HSA-5218900	7.556022e-01	0.122
Gap junction degradation	R-HSA-190873	7.556022e-01	0.122
Calcineurin activates NFAT	R-HSA-2025928	7.556022e-01	0.122
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	7.556022e-01	0.122
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	7.556022e-01	0.122
mRNA Editing	R-HSA-75072	7.556022e-01	0.122
Regulation of signaling by NODAL	R-HSA-1433617	7.556022e-01	0.122
MASTL Facilitates Mitotic Progression	R-HSA-2465910	7.556022e-01	0.122
WNT mediated activation of DVL	R-HSA-201688	7.556022e-01	0.122
Lipophagy	R-HSA-9613354	7.556022e-01	0.122
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	7.556022e-01	0.122
Regulated proteolysis of p75NTR	R-HSA-193692	7.556022e-01	0.122
Cellular response to mitochondrial stress	R-HSA-9840373	7.556022e-01	0.122
Protein folding	R-HSA-391251	7.559558e-01	0.122
Collagen chain trimerization	R-HSA-8948216	7.576670e-01	0.121
Condensation of Prophase Chromosomes	R-HSA-2299718	7.581053e-01	0.120
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	7.603794e-01	0.119
Signaling by FGFR1	R-HSA-5654736	7.603794e-01	0.119
Intrinsic Pathway for Apoptosis	R-HSA-109606	7.603794e-01	0.119
Negative regulation of FGFR3 signaling	R-HSA-5654732	7.608200e-01	0.119
Extra-nuclear estrogen signaling	R-HSA-9009391	7.615028e-01	0.118
Pre-NOTCH Processing in Golgi	R-HSA-1912420	7.720062e-01	0.112
IKK complex recruitment mediated by RIP1	R-HSA-937041	7.720062e-01	0.112
Crosslinking of collagen fibrils	R-HSA-2243919	7.720062e-01	0.112
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	7.720062e-01	0.112
Rap1 signalling	R-HSA-392517	7.720062e-01	0.112
Specification of the neural plate border	R-HSA-9834899	7.720062e-01	0.112
STING mediated induction of host immune responses	R-HSA-1834941	7.720062e-01	0.112
Maturation of nucleoprotein	R-HSA-9694631	7.720062e-01	0.112
MET promotes cell motility	R-HSA-8875878	7.727039e-01	0.112
SLC-mediated transport of inorganic anions	R-HSA-9958790	7.727039e-01	0.112
Cell junction organization	R-HSA-446728	7.741908e-01	0.111
Negative regulation of FGFR4 signaling	R-HSA-5654733	7.776065e-01	0.109
Signaling by CSF3 (G-CSF)	R-HSA-9674555	7.776065e-01	0.109
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	7.826875e-01	0.106
DNA replication initiation	R-HSA-68952	7.826875e-01	0.106
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	7.826875e-01	0.106
Regulation of the apoptosome activity	R-HSA-9627069	7.826875e-01	0.106
Formation of apoptosome	R-HSA-111458	7.826875e-01	0.106
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	7.826875e-01	0.106
Arachidonate production from DAG	R-HSA-426048	7.826875e-01	0.106
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	7.826875e-01	0.106
Interleukin-27 signaling	R-HSA-9020956	7.826875e-01	0.106
Apoptosis induced DNA fragmentation	R-HSA-140342	7.826875e-01	0.106
Josephin domain DUBs	R-HSA-5689877	7.826875e-01	0.106
Cell-Cell communication	R-HSA-1500931	7.838045e-01	0.106
Cellular responses to stress	R-HSA-2262752	7.840120e-01	0.106
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	7.856253e-01	0.105
Stabilization of p53	R-HSA-69541	7.869965e-01	0.104
Beta-catenin independent WNT signaling	R-HSA-3858494	7.903766e-01	0.102
Regulation of PD-L1(CD274) translation	R-HSA-9909620	7.910458e-01	0.102
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	7.910458e-01	0.102
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	7.934110e-01	0.101
Regulation of PD-L1(CD274) expression	R-HSA-9909648	7.945556e-01	0.100
Attenuation phase	R-HSA-3371568	8.005618e-01	0.097
Aggrephagy	R-HSA-9646399	8.005618e-01	0.097
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	8.005618e-01	0.097
COPI-mediated anterograde transport	R-HSA-6807878	8.039031e-01	0.095
Autophagy	R-HSA-9612973	8.064589e-01	0.093
Class I MHC mediated antigen processing & presentation	R-HSA-983169	8.064900e-01	0.093
DAG1 core M3 glycosylations	R-HSA-8932505	8.067725e-01	0.093
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	8.067725e-01	0.093
Ionotropic activity of kainate receptors	R-HSA-451306	8.067725e-01	0.093
RHOBTB3 ATPase cycle	R-HSA-9706019	8.067725e-01	0.093
Bicarbonate transporters	R-HSA-425381	8.067725e-01	0.093
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	8.067725e-01	0.093
Chylomicron assembly	R-HSA-8963888	8.067725e-01	0.093
Suppression of apoptosis	R-HSA-9635465	8.067725e-01	0.093
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	8.076214e-01	0.093
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	8.082672e-01	0.092
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	8.082672e-01	0.092
Lagging Strand Synthesis	R-HSA-69186	8.086672e-01	0.092
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	8.086672e-01	0.092
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	8.086672e-01	0.092
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	8.086672e-01	0.092
Early Phase of HIV Life Cycle	R-HSA-162594	8.086672e-01	0.092
Signaling by FGFR2 in disease	R-HSA-5655253	8.092058e-01	0.092
ER to Golgi Anterograde Transport	R-HSA-199977	8.094447e-01	0.092
SARS-CoV-2 Infection	R-HSA-9694516	8.128852e-01	0.090
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	8.134188e-01	0.090
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	8.134188e-01	0.090
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	8.175675e-01	0.087
Base Excision Repair	R-HSA-73884	8.192596e-01	0.087
Cytokine Signaling in Immune system	R-HSA-1280215	8.195168e-01	0.086
Vesicle-mediated transport	R-HSA-5653656	8.195541e-01	0.086
HSF1-dependent transactivation	R-HSA-3371571	8.205420e-01	0.086
Activation of NF-kappaB in B cells	R-HSA-1169091	8.205420e-01	0.086
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	8.222110e-01	0.085
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	8.222110e-01	0.085
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	8.222110e-01	0.085
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	8.249508e-01	0.084
FRS-mediated FGFR3 signaling	R-HSA-5654706	8.249508e-01	0.084
Molybdenum cofactor biosynthesis	R-HSA-947581	8.249508e-01	0.084
Degradation of CRY and PER proteins	R-HSA-9932298	8.255883e-01	0.083
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	8.255883e-01	0.083
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	8.255883e-01	0.083
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	8.255883e-01	0.083
Cytochrome c-mediated apoptotic response	R-HSA-111461	8.281893e-01	0.082
Sensing of DNA Double Strand Breaks	R-HSA-5693548	8.281893e-01	0.082
Reduction of cytosolic Ca++ levels	R-HSA-418359	8.281893e-01	0.082
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	8.281893e-01	0.082
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	8.281893e-01	0.082
DS-GAG biosynthesis	R-HSA-2022923	8.281893e-01	0.082
Integration of provirus	R-HSA-162592	8.281893e-01	0.082
Potential therapeutics for SARS	R-HSA-9679191	8.297754e-01	0.081
Regulation of necroptotic cell death	R-HSA-5675482	8.352797e-01	0.078
Negative regulation of FGFR1 signaling	R-HSA-5654726	8.352797e-01	0.078
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	8.352797e-01	0.078
Integrin signaling	R-HSA-354192	8.352797e-01	0.078
KEAP1-NFE2L2 pathway	R-HSA-9755511	8.361822e-01	0.078
Ca2+ pathway	R-HSA-4086398	8.362528e-01	0.078
Ca-dependent events	R-HSA-111996	8.370922e-01	0.077
rRNA modification in the nucleus and cytosol	R-HSA-6790901	8.380120e-01	0.077
Influenza Infection	R-HSA-168255	8.389415e-01	0.076
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	8.399767e-01	0.076
FRS-mediated FGFR4 signaling	R-HSA-5654712	8.399767e-01	0.076
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	8.399767e-01	0.076
mTORC1-mediated signalling	R-HSA-166208	8.399767e-01	0.076
Signaling by KIT in disease	R-HSA-9669938	8.399767e-01	0.076
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	8.399767e-01	0.076
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	8.399767e-01	0.076
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	8.415811e-01	0.075
Signaling by ERBB4	R-HSA-1236394	8.450081e-01	0.073
Developmental Biology	R-HSA-1266738	8.455567e-01	0.073
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	8.472335e-01	0.072
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	8.472335e-01	0.072
Polymerase switching	R-HSA-69091	8.472335e-01	0.072
IRAK1 recruits IKK complex	R-HSA-937039	8.472335e-01	0.072
Leading Strand Synthesis	R-HSA-69109	8.472335e-01	0.072
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	8.472335e-01	0.072
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	8.472335e-01	0.072
Diseases associated with surfactant metabolism	R-HSA-5687613	8.472335e-01	0.072
Interleukin-35 Signalling	R-HSA-8984722	8.472335e-01	0.072
OAS antiviral response	R-HSA-8983711	8.472335e-01	0.072
Striated Muscle Contraction	R-HSA-390522	8.475116e-01	0.072
Glucagon signaling in metabolic regulation	R-HSA-163359	8.475116e-01	0.072
Vpu mediated degradation of CD4	R-HSA-180534	8.475116e-01	0.072
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	8.502563e-01	0.070
Non-integrin membrane-ECM interactions	R-HSA-3000171	8.533835e-01	0.069
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	8.538235e-01	0.069
Organic anion transport by SLCO transporters	R-HSA-879518	8.538235e-01	0.069
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	8.538235e-01	0.069
Formation of the ureteric bud	R-HSA-9830674	8.538235e-01	0.069
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	8.580514e-01	0.066
EPHB-mediated forward signaling	R-HSA-3928662	8.581960e-01	0.066
Proteasome assembly	R-HSA-9907900	8.581960e-01	0.066
DAP12 interactions	R-HSA-2172127	8.581960e-01	0.066
Signaling by NOTCH2	R-HSA-1980145	8.589455e-01	0.066
Negative regulation of FGFR2 signaling	R-HSA-5654727	8.589455e-01	0.066
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	8.589455e-01	0.066
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	8.589455e-01	0.066
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	8.589455e-01	0.066
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	8.641677e-01	0.063
Adenylate cyclase activating pathway	R-HSA-170660	8.641677e-01	0.063
PDH complex synthesizes acetyl-CoA from PYR	R-HSA-9861559	8.641677e-01	0.063
Platelet Adhesion to exposed collagen	R-HSA-75892	8.641677e-01	0.063
Chylomicron remodeling	R-HSA-8963901	8.641677e-01	0.063
Processing of SMDT1	R-HSA-8949664	8.641677e-01	0.063
CD28 dependent Vav1 pathway	R-HSA-389359	8.641677e-01	0.063
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	8.641677e-01	0.063
Maturation of nucleoprotein	R-HSA-9683610	8.641677e-01	0.063
Replication of the SARS-CoV-1 genome	R-HSA-9682706	8.641677e-01	0.063
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	8.665679e-01	0.062
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	8.665679e-01	0.062
TNFs bind their physiological receptors	R-HSA-5669034	8.665679e-01	0.062
Plasma lipoprotein assembly	R-HSA-8963898	8.665679e-01	0.062
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	8.665679e-01	0.062
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	8.678440e-01	0.062
Fanconi Anemia Pathway	R-HSA-6783310	8.678440e-01	0.062
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	8.678440e-01	0.062
Platelet Aggregation (Plug Formation)	R-HSA-76009	8.678440e-01	0.062
HCMV Infection	R-HSA-9609646	8.681218e-01	0.061
PERK regulates gene expression	R-HSA-381042	8.696204e-01	0.061
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	8.696204e-01	0.061
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	8.696204e-01	0.061
Regulation of Apoptosis	R-HSA-169911	8.696204e-01	0.061
SARS-CoV Infections	R-HSA-9679506	8.715731e-01	0.060
Unfolded Protein Response (UPR)	R-HSA-381119	8.737061e-01	0.059
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	8.769221e-01	0.057
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	8.779548e-01	0.057
Maternal to zygotic transition (MZT)	R-HSA-9816359	8.779548e-01	0.057
FRS-mediated FGFR1 signaling	R-HSA-5654693	8.782842e-01	0.056
Acyl chain remodelling of PS	R-HSA-1482801	8.782842e-01	0.056
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	8.782842e-01	0.056
Laminin interactions	R-HSA-3000157	8.782842e-01	0.056
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	8.782842e-01	0.056
Removal of the Flap Intermediate	R-HSA-69166	8.792257e-01	0.056
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	8.792257e-01	0.056
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	8.792257e-01	0.056
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	8.792257e-01	0.056
CRMPs in Sema3A signaling	R-HSA-399956	8.792257e-01	0.056
HDL assembly	R-HSA-8963896	8.792257e-01	0.056
Signal regulatory protein family interactions	R-HSA-391160	8.792257e-01	0.056
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	8.792257e-01	0.056
GPVI-mediated activation cascade	R-HSA-114604	8.795750e-01	0.056
Vif-mediated degradation of APOBEC3G	R-HSA-180585	8.795750e-01	0.056
FGFR2 mutant receptor activation	R-HSA-1839126	8.795750e-01	0.056
Interferon Signaling	R-HSA-913531	8.798770e-01	0.056
Dual incision in TC-NER	R-HSA-6782135	8.853959e-01	0.053
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	8.871418e-01	0.052
Cleavage of the damaged purine	R-HSA-110331	8.888476e-01	0.051
Degradation of DVL	R-HSA-4641258	8.888476e-01	0.051
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	8.888476e-01	0.051
MET activates PTK2 signaling	R-HSA-8874081	8.890436e-01	0.051
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	8.890436e-01	0.051
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	8.890436e-01	0.051
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	8.890436e-01	0.051
Suppression of phagosomal maturation	R-HSA-9637687	8.890436e-01	0.051
PKR-mediated signaling	R-HSA-9833482	8.899025e-01	0.051
Signaling by FGFR	R-HSA-190236	8.912095e-01	0.050
Adenylate cyclase inhibitory pathway	R-HSA-170670	8.926151e-01	0.049
G beta:gamma signalling through BTK	R-HSA-8964315	8.926151e-01	0.049
ERBB2 Regulates Cell Motility	R-HSA-6785631	8.926151e-01	0.049
Translesion synthesis by REV1	R-HSA-110312	8.926151e-01	0.049
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	8.926151e-01	0.049
DNA Damage Reversal	R-HSA-73942	8.926151e-01	0.049
Lysosphingolipid and LPA receptors	R-HSA-419408	8.926151e-01	0.049
Other semaphorin interactions	R-HSA-416700	8.926151e-01	0.049
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	8.927896e-01	0.049
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	8.939633e-01	0.049
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	8.939633e-01	0.049
RIPK1-mediated regulated necrosis	R-HSA-5213460	8.974757e-01	0.047
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	8.974757e-01	0.047
Depurination	R-HSA-73927	8.974757e-01	0.047
Interaction between L1 and Ankyrins	R-HSA-445095	8.989142e-01	0.046
Packaging Of Telomere Ends	R-HSA-171306	8.989142e-01	0.046
EPHA-mediated growth cone collapse	R-HSA-3928663	8.989142e-01	0.046
Signaling by FGFR3 in disease	R-HSA-5655332	8.989142e-01	0.046
Insulin processing	R-HSA-264876	8.989142e-01	0.046
Maturation of hRSV A proteins	R-HSA-9828806	8.989142e-01	0.046
NoRC negatively regulates rRNA expression	R-HSA-427413	9.004296e-01	0.046
DNA Damage Bypass	R-HSA-73893	9.009823e-01	0.045
Degradation of CDH1	R-HSA-9766229	9.009823e-01	0.045
Translesion synthesis by POLI	R-HSA-5656121	9.045209e-01	0.044
Defective GALNT12 causes CRCS1	R-HSA-5083636	9.045209e-01	0.044
Defective GALNT3 causes HFTC	R-HSA-5083625	9.045209e-01	0.044
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	9.045209e-01	0.044
Class I peroxisomal membrane protein import	R-HSA-9603798	9.045209e-01	0.044
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	9.045209e-01	0.044
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	9.045209e-01	0.044
Induction of Cell-Cell Fusion	R-HSA-9733458	9.045209e-01	0.044
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	9.045209e-01	0.044
Killing mechanisms	R-HSA-9664420	9.045209e-01	0.044
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.054959e-01	0.043
Plasma lipoprotein clearance	R-HSA-8964043	9.054959e-01	0.043
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.054959e-01	0.043
Aquaporin-mediated transport	R-HSA-445717	9.063481e-01	0.043
Interleukin-1 signaling	R-HSA-9020702	9.074810e-01	0.042
Activation of AMPK downstream of NMDARs	R-HSA-9619483	9.079608e-01	0.042
FRS-mediated FGFR2 signaling	R-HSA-5654700	9.079608e-01	0.042
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.079608e-01	0.042
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	9.079608e-01	0.042
Cell-cell junction organization	R-HSA-421270	9.084157e-01	0.042
Signaling by Insulin receptor	R-HSA-74752	9.099480e-01	0.041
Generation of second messenger molecules	R-HSA-202433	9.129438e-01	0.040
Nuclear signaling by ERBB4	R-HSA-1251985	9.129438e-01	0.040
Hedgehog ligand biogenesis	R-HSA-5358346	9.146205e-01	0.039
G beta:gamma signalling through CDC42	R-HSA-8964616	9.151073e-01	0.039
Translesion synthesis by POLK	R-HSA-5655862	9.151073e-01	0.039
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	9.151073e-01	0.039
Glycine degradation	R-HSA-6783984	9.151073e-01	0.039
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	9.151073e-01	0.039
Coenzyme A biosynthesis	R-HSA-196783	9.151073e-01	0.039
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	9.151073e-01	0.039
Passive transport by Aquaporins	R-HSA-432047	9.151073e-01	0.039
Synthesis of PG	R-HSA-1483148	9.151073e-01	0.039
Scavenging by Class B Receptors	R-HSA-3000471	9.151073e-01	0.039
tRNA modification in the mitochondrion	R-HSA-6787450	9.151073e-01	0.039
Cellular responses to stimuli	R-HSA-8953897	9.153370e-01	0.038
HCMV Late Events	R-HSA-9610379	9.155718e-01	0.038
Late endosomal microautophagy	R-HSA-9615710	9.162448e-01	0.038
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	9.162448e-01	0.038
Termination of translesion DNA synthesis	R-HSA-5656169	9.162448e-01	0.038
Platelet calcium homeostasis	R-HSA-418360	9.162448e-01	0.038
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.162448e-01	0.038
Glucagon-type ligand receptors	R-HSA-420092	9.162448e-01	0.038
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	9.198065e-01	0.036
Hh mutants are degraded by ERAD	R-HSA-5362768	9.198538e-01	0.036
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.207897e-01	0.036
Uptake and actions of bacterial toxins	R-HSA-5339562	9.207897e-01	0.036
Response of endothelial cells to shear stress	R-HSA-9860931	9.216480e-01	0.035
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.238239e-01	0.034
Regulation of T cell activation by CD28 family	R-HSA-388841	9.238431e-01	0.034
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	9.238732e-01	0.034
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	9.245204e-01	0.034
PI3K events in ERBB2 signaling	R-HSA-1963642	9.245204e-01	0.034
Glycogen storage diseases	R-HSA-3229121	9.245204e-01	0.034
Elevation of cytosolic Ca2+ levels	R-HSA-139853	9.245204e-01	0.034
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	9.245204e-01	0.034
Replication of the SARS-CoV-2 genome	R-HSA-9694686	9.245204e-01	0.034
Heme biosynthesis	R-HSA-189451	9.262590e-01	0.033
Golgi Associated Vesicle Biogenesis	R-HSA-432722	9.265560e-01	0.033
Amino acids regulate mTORC1	R-HSA-9639288	9.265560e-01	0.033
Smooth Muscle Contraction	R-HSA-445355	9.265560e-01	0.033
RNA Polymerase I Promoter Clearance	R-HSA-73854	9.279037e-01	0.032
Co-inhibition by PD-1	R-HSA-389948	9.294317e-01	0.032
Cellular response to chemical stress	R-HSA-9711123	9.300830e-01	0.031
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.307526e-01	0.031
Translation initiation complex formation	R-HSA-72649	9.319411e-01	0.031
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.321388e-01	0.031
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	9.321912e-01	0.030
CLEC7A (Dectin-1) signaling	R-HSA-5607764	9.328466e-01	0.030
GAB1 signalosome	R-HSA-180292	9.328903e-01	0.030
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	9.328903e-01	0.030
RNA Polymerase III Transcription Termination	R-HSA-73980	9.328903e-01	0.030
Apoptotic factor-mediated response	R-HSA-111471	9.328903e-01	0.030
PKA activation	R-HSA-163615	9.328903e-01	0.030
Platelet sensitization by LDL	R-HSA-432142	9.328903e-01	0.030
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.338778e-01	0.030
Interferon alpha/beta signaling	R-HSA-909733	9.353319e-01	0.029
RNA Polymerase I Transcription	R-HSA-73864	9.368706e-01	0.028
Response of Mtb to phagocytosis	R-HSA-9637690	9.376808e-01	0.028
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.376808e-01	0.028
PI-3K cascade:FGFR3	R-HSA-5654710	9.403325e-01	0.027
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	9.403325e-01	0.027
Translesion Synthesis by POLH	R-HSA-110320	9.403325e-01	0.027
Diseases of hemostasis	R-HSA-9671793	9.403325e-01	0.027
HDL remodeling	R-HSA-8964058	9.403325e-01	0.027
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	9.403325e-01	0.027
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	9.403325e-01	0.027
Stimuli-sensing channels	R-HSA-2672351	9.411311e-01	0.026
Ribosomal scanning and start codon recognition	R-HSA-72702	9.416520e-01	0.026
Amine ligand-binding receptors	R-HSA-375280	9.427568e-01	0.026
Surfactant metabolism	R-HSA-5683826	9.427568e-01	0.026
Assembly of the ORC complex at the origin of replication	R-HSA-68616	9.428597e-01	0.026
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	9.448320e-01	0.025
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	9.448320e-01	0.025
Regulation of CDH1 Function	R-HSA-9764561	9.460178e-01	0.024
PI-3K cascade:FGFR4	R-HSA-5654720	9.469498e-01	0.024
Glycogen synthesis	R-HSA-3322077	9.469498e-01	0.024
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	9.469498e-01	0.024
Pregnenolone biosynthesis	R-HSA-196108	9.469498e-01	0.024
Protein hydroxylation	R-HSA-9629569	9.469498e-01	0.024
SLC transporter disorders	R-HSA-5619102	9.472727e-01	0.024
Phospholipid metabolism	R-HSA-1483257	9.472951e-01	0.024
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.474467e-01	0.023
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.474467e-01	0.023
TCR signaling	R-HSA-202403	9.476493e-01	0.023
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	9.481302e-01	0.023
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.481302e-01	0.023
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	9.481302e-01	0.023
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	9.500826e-01	0.022
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	9.517769e-01	0.021
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.528335e-01	0.021
Matriglycan biosynthesis on DAG1	R-HSA-9939291	9.528335e-01	0.021
PKA-mediated phosphorylation of CREB	R-HSA-111931	9.528335e-01	0.021
Basigin interactions	R-HSA-210991	9.528335e-01	0.021
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	9.528335e-01	0.021
Dual Incision in GG-NER	R-HSA-5696400	9.529348e-01	0.021
eNOS activation	R-HSA-203615	9.529348e-01	0.021
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.529348e-01	0.021
Peroxisomal protein import	R-HSA-9033241	9.538645e-01	0.021
Amino acid transport across the plasma membrane	R-HSA-352230	9.538645e-01	0.021
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.550928e-01	0.020
Synthesis of PC	R-HSA-1483191	9.557720e-01	0.020
trans-Golgi Network Vesicle Budding	R-HSA-199992	9.572026e-01	0.019
Signaling by Retinoic Acid	R-HSA-5362517	9.573808e-01	0.019
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.580650e-01	0.019
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	9.580650e-01	0.019
Mitochondrial calcium ion transport	R-HSA-8949215	9.580650e-01	0.019
Cellular responses to mechanical stimuli	R-HSA-9855142	9.588026e-01	0.018
Opioid Signalling	R-HSA-111885	9.589770e-01	0.018
Collagen degradation	R-HSA-1442490	9.606479e-01	0.017
PLC beta mediated events	R-HSA-112043	9.606479e-01	0.017
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	9.609015e-01	0.017
HSF1 activation	R-HSA-3371511	9.612979e-01	0.017
Regulation of IFNA/IFNB signaling	R-HSA-912694	9.627165e-01	0.017
PI-3K cascade:FGFR1	R-HSA-5654689	9.627165e-01	0.017
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.627165e-01	0.017
Ethanol oxidation	R-HSA-71384	9.627165e-01	0.017
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.627165e-01	0.017
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.635946e-01	0.016
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	9.636815e-01	0.016
Metabolism of folate and pterines	R-HSA-196757	9.649249e-01	0.016
Termination of O-glycan biosynthesis	R-HSA-977068	9.668523e-01	0.015
Interleukin-20 family signaling	R-HSA-8854691	9.668523e-01	0.015
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	9.668523e-01	0.015
Carnitine shuttle	R-HSA-200425	9.668523e-01	0.015
Integration of energy metabolism	R-HSA-163685	9.695675e-01	0.013
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.712226e-01	0.013
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	9.714953e-01	0.013
Transcriptional Regulation by NPAS4	R-HSA-9634815	9.714953e-01	0.013
ER-Phagosome pathway	R-HSA-1236974	9.726465e-01	0.012
Interleukin-10 signaling	R-HSA-6783783	9.727626e-01	0.012
Activation of G protein gated Potassium channels	R-HSA-1296041	9.737990e-01	0.012
G protein gated Potassium channels	R-HSA-1296059	9.737990e-01	0.012
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	9.737990e-01	0.012
PI-3K cascade:FGFR2	R-HSA-5654695	9.737990e-01	0.012
Defects in cobalamin (B12) metabolism	R-HSA-3296469	9.737990e-01	0.012
Beta-oxidation of pristanoyl-CoA	R-HSA-389887	9.737990e-01	0.012
Alpha-oxidation of phytanate	R-HSA-389599	9.737990e-01	0.012
Glycogen breakdown (glycogenolysis)	R-HSA-70221	9.737990e-01	0.012
Glycogen metabolism	R-HSA-8982491	9.739474e-01	0.011
Downstream TCR signaling	R-HSA-202424	9.745594e-01	0.011
G-protein mediated events	R-HSA-112040	9.758433e-01	0.011
SLC-mediated transport of amino acids	R-HSA-9958863	9.758433e-01	0.011
Kidney development	R-HSA-9830369	9.758433e-01	0.011
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	9.764220e-01	0.010
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	9.764220e-01	0.010
Maturation of spike protein	R-HSA-9694548	9.764220e-01	0.010
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	9.767060e-01	0.010
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.767060e-01	0.010
Attachment of bacteria to epithelial cells	R-HSA-9638630	9.767060e-01	0.010
Urea cycle	R-HSA-70635	9.767060e-01	0.010
Nonsense-Mediated Decay (NMD)	R-HSA-927802	9.771601e-01	0.010
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	9.771601e-01	0.010
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.777633e-01	0.010
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	9.782105e-01	0.010
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.786684e-01	0.009
Scavenging by Class A Receptors	R-HSA-3000480	9.786684e-01	0.009
RNA Polymerase I Transcription Termination	R-HSA-73863	9.792906e-01	0.009
Cobalamin (Cbl) metabolism	R-HSA-9759218	9.792906e-01	0.009
Cristae formation	R-HSA-8949613	9.792906e-01	0.009
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	9.792906e-01	0.009
Triglyceride biosynthesis	R-HSA-75109	9.792906e-01	0.009
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.792906e-01	0.009
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.795806e-01	0.009
Ion homeostasis	R-HSA-5578775	9.800923e-01	0.009
GABA B receptor activation	R-HSA-977444	9.807068e-01	0.008
Activation of GABAB receptors	R-HSA-991365	9.807068e-01	0.008
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	9.810256e-01	0.008
SARS-CoV-1 Infection	R-HSA-9678108	9.810977e-01	0.008
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.815885e-01	0.008
Iron assimilation using enterobactin	R-HSA-9638334	9.815885e-01	0.008
Defective pyroptosis	R-HSA-9710421	9.825556e-01	0.008
DNA methylation	R-HSA-5334118	9.836316e-01	0.007
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.836316e-01	0.007
Neddylation	R-HSA-8951664	9.847717e-01	0.007
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.848493e-01	0.007
Platelet activation, signaling and aggregation	R-HSA-76002	9.850681e-01	0.007
Transport to the Golgi and subsequent modification	R-HSA-948021	9.859247e-01	0.006
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.861792e-01	0.006
Metabolism of polyamines	R-HSA-351202	9.861792e-01	0.006
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.866776e-01	0.006
Antigen processing-Cross presentation	R-HSA-1236975	9.867367e-01	0.006
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	9.867367e-01	0.006
Budding and maturation of HIV virion	R-HSA-162588	9.870630e-01	0.006
Molecules associated with elastic fibres	R-HSA-2129379	9.870630e-01	0.006
Regulation of pyruvate metabolism	R-HSA-9861718	9.871272e-01	0.006
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.871272e-01	0.006
Regulation of RUNX2 expression and activity	R-HSA-8939902	9.873951e-01	0.006
Post NMDA receptor activation events	R-HSA-438064	9.875857e-01	0.005
Protein ubiquitination	R-HSA-8852135	9.876790e-01	0.005
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	9.883736e-01	0.005
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	9.883736e-01	0.005
DAG1 glycosylations	R-HSA-8931838	9.884989e-01	0.005
Inwardly rectifying K+ channels	R-HSA-1296065	9.884989e-01	0.005
NCAM signaling for neurite out-growth	R-HSA-375165	9.885079e-01	0.005
Mitochondrial protein import	R-HSA-1268020	9.885079e-01	0.005
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.888756e-01	0.005
Nuclear events mediated by NFE2L2	R-HSA-9759194	9.892701e-01	0.005
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.894541e-01	0.005
Intraflagellar transport	R-HSA-5620924	9.895020e-01	0.005
Plasma lipoprotein remodeling	R-HSA-8963899	9.895020e-01	0.005
Translation of Structural Proteins	R-HSA-9694635	9.896251e-01	0.005
Recycling of bile acids and salts	R-HSA-159418	9.897754e-01	0.004
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.897754e-01	0.004
Protein localization	R-HSA-9609507	9.898878e-01	0.004
FCERI mediated MAPK activation	R-HSA-2871796	9.901013e-01	0.004
Neurotransmitter release cycle	R-HSA-112310	9.902619e-01	0.004
Class B/2 (Secretin family receptors)	R-HSA-373080	9.902619e-01	0.004
Gap junction trafficking and regulation	R-HSA-157858	9.905232e-01	0.004
Acyl chain remodelling of PC	R-HSA-1482788	9.909103e-01	0.004
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	9.911339e-01	0.004
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	9.913072e-01	0.004
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	9.919194e-01	0.004
Hyaluronan metabolism	R-HSA-2142845	9.919194e-01	0.004
NPAS4 regulates expression of target genes	R-HSA-9768919	9.919194e-01	0.004
Meiotic recombination	R-HSA-912446	9.922828e-01	0.003
Cytosolic sulfonation of small molecules	R-HSA-156584	9.922828e-01	0.003
The phototransduction cascade	R-HSA-2514856	9.922828e-01	0.003
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.923839e-01	0.003
Cellular response to starvation	R-HSA-9711097	9.926810e-01	0.003
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.926810e-01	0.003
Nicotinate metabolism	R-HSA-196807	9.927942e-01	0.003
Acyl chain remodelling of PE	R-HSA-1482839	9.928164e-01	0.003
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.928164e-01	0.003
Transferrin endocytosis and recycling	R-HSA-917977	9.928164e-01	0.003
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.929874e-01	0.003
Regulated Necrosis	R-HSA-5218859	9.934423e-01	0.003
Platelet degranulation	R-HSA-114608	9.934989e-01	0.003
Collagen formation	R-HSA-1474290	9.935451e-01	0.003
PRC2 methylates histones and DNA	R-HSA-212300	9.936139e-01	0.003
Glycosphingolipid transport	R-HSA-9845576	9.936139e-01	0.003
Lysosome Vesicle Biogenesis	R-HSA-432720	9.936139e-01	0.003
Triglyceride catabolism	R-HSA-163560	9.936139e-01	0.003
C-type lectin receptors (CLRs)	R-HSA-5621481	9.937399e-01	0.003
Platelet homeostasis	R-HSA-418346	9.940118e-01	0.003
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.943229e-01	0.002
NCAM1 interactions	R-HSA-419037	9.943229e-01	0.002
SLC-mediated transport of organic cations	R-HSA-549127	9.943229e-01	0.002
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	9.943386e-01	0.002
Peroxisomal lipid metabolism	R-HSA-390918	9.943732e-01	0.002
Leishmania phagocytosis	R-HSA-9664417	9.946905e-01	0.002
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.946905e-01	0.002
Parasite infection	R-HSA-9664407	9.946905e-01	0.002
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.949533e-01	0.002
Elastic fibre formation	R-HSA-1566948	9.949533e-01	0.002
Biofilm formation	R-HSA-9931953	9.949533e-01	0.002
Purine salvage	R-HSA-74217	9.949533e-01	0.002
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.950653e-01	0.002
ECM proteoglycans	R-HSA-3000178	9.950653e-01	0.002
Metabolism of porphyrins	R-HSA-189445	9.950653e-01	0.002
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.953998e-01	0.002
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.955137e-01	0.002
Pentose phosphate pathway	R-HSA-71336	9.955137e-01	0.002
RAS processing	R-HSA-9648002	9.955137e-01	0.002
Regulation of insulin secretion	R-HSA-422356	9.957539e-01	0.002
Synthesis of PA	R-HSA-1483166	9.958546e-01	0.002
Diseases of Immune System	R-HSA-5260271	9.960119e-01	0.002
Diseases associated with the TLR signaling cascade	R-HSA-5602358	9.960119e-01	0.002
Interleukin-12 family signaling	R-HSA-447115	9.960591e-01	0.002
Disorders of transmembrane transporters	R-HSA-5619115	9.963816e-01	0.002
ABC-family proteins mediated transport	R-HSA-382556	9.964160e-01	0.002
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.966347e-01	0.001
Triglyceride metabolism	R-HSA-8979227	9.966355e-01	0.001
Translation of Structural Proteins	R-HSA-9683701	9.968485e-01	0.001
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.969392e-01	0.001
Interleukin-12 signaling	R-HSA-9020591	9.969437e-01	0.001
GABA receptor activation	R-HSA-977443	9.969698e-01	0.001
RAB geranylgeranylation	R-HSA-8873719	9.969698e-01	0.001
Adaptive Immune System	R-HSA-1280218	9.970025e-01	0.001
G alpha (s) signalling events	R-HSA-418555	9.971428e-01	0.001
Cytosolic tRNA aminoacylation	R-HSA-379716	9.971985e-01	0.001
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.971985e-01	0.001
Endogenous sterols	R-HSA-211976	9.972714e-01	0.001
ABC transporter disorders	R-HSA-5619084	9.974810e-01	0.001
Defensins	R-HSA-1461973	9.975097e-01	0.001
Ribosome-associated quality control	R-HSA-9948299	9.975298e-01	0.001
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.977863e-01	0.001
Gap junction trafficking	R-HSA-190828	9.977863e-01	0.001
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.977863e-01	0.001
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.979341e-01	0.001
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.979719e-01	0.001
Ion transport by P-type ATPases	R-HSA-936837	9.980097e-01	0.001
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.980322e-01	0.001
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	9.981359e-01	0.001
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	9.983504e-01	0.001
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	9.983504e-01	0.001
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.984451e-01	0.001
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.985503e-01	0.001
Gluconeogenesis	R-HSA-70263	9.986179e-01	0.001
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	9.986961e-01	0.001
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.987715e-01	0.001
Chemokine receptors bind chemokines	R-HSA-380108	9.987715e-01	0.001
Interferon gamma signaling	R-HSA-877300	9.987785e-01	0.001
Azathioprine ADME	R-HSA-9748787	9.989080e-01	0.000
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.989455e-01	0.000
Complex IV assembly	R-HSA-9864848	9.990293e-01	0.000
Metabolism of cofactors	R-HSA-8978934	9.990520e-01	0.000
RNA Polymerase I Promoter Escape	R-HSA-73772	9.991372e-01	0.000
Developmental Lineages of the Mammary Gland	R-HSA-9924644	9.991478e-01	0.000
Muscle contraction	R-HSA-397014	9.991675e-01	0.000
Ion channel transport	R-HSA-983712	9.992042e-01	0.000
Diseases of carbohydrate metabolism	R-HSA-5663084	9.992340e-01	0.000
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.992553e-01	0.000
ROS and RNS production in phagocytes	R-HSA-1222556	9.993116e-01	0.000
Cap-dependent Translation Initiation	R-HSA-72737	9.993190e-01	0.000
Eukaryotic Translation Initiation	R-HSA-72613	9.993190e-01	0.000
Iron uptake and transport	R-HSA-917937	9.993814e-01	0.000
Paracetamol ADME	R-HSA-9753281	9.993941e-01	0.000
Chondroitin sulfate/dermatan sulfate metabolism	R-HSA-1793185	9.993941e-01	0.000
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	9.994245e-01	0.000
Cardiac conduction	R-HSA-5576891	9.994616e-01	0.000
Dectin-2 family	R-HSA-5621480	9.995213e-01	0.000
Integrin cell surface interactions	R-HSA-216083	9.995515e-01	0.000
Cholesterol biosynthesis	R-HSA-191273	9.995515e-01	0.000
SLC-mediated transport of organic anions	R-HSA-9955298	9.995515e-01	0.000
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.995745e-01	0.000
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.995972e-01	0.000
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	9.996145e-01	0.000
Viral Infection Pathways	R-HSA-9824446	9.996354e-01	0.000
Formation of a pool of free 40S subunits	R-HSA-72689	9.996514e-01	0.000
tRNA Aminoacylation	R-HSA-379724	9.996639e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.996848e-01	0.000
Nucleotide salvage	R-HSA-8956321	9.997012e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.997191e-01	0.000
Post-translational protein phosphorylation	R-HSA-8957275	9.997424e-01	0.000
Xenobiotics	R-HSA-211981	9.997902e-01	0.000
Pyruvate metabolism	R-HSA-70268	9.998476e-01	0.000
Metabolism of steroid hormones	R-HSA-196071	9.998527e-01	0.000
FCERI mediated NF-kB activation	R-HSA-2871837	9.998559e-01	0.000
Peptide chain elongation	R-HSA-156902	9.998632e-01	0.000
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.998632e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.998683e-01	0.000
O-linked glycosylation of mucins	R-HSA-913709	9.998691e-01	0.000
Developmental Cell Lineages	R-HSA-9734767	9.998705e-01	0.000
G alpha (q) signalling events	R-HSA-416476	9.998794e-01	0.000
Hemostasis	R-HSA-109582	9.998885e-01	0.000
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	9.999013e-01	0.000
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.999070e-01	0.000
Retinoid metabolism and transport	R-HSA-975634	9.999081e-01	0.000
Metal ion assimilation from the host	R-HSA-9638482	9.999081e-01	0.000
Purine catabolism	R-HSA-74259	9.999183e-01	0.000
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.999183e-01	0.000
Eukaryotic Translation Elongation	R-HSA-156842	9.999206e-01	0.000
rRNA processing	R-HSA-72312	9.999236e-01	0.000
Formation of the cornified envelope	R-HSA-6809371	9.999245e-01	0.000
Eukaryotic Translation Termination	R-HSA-72764	9.999487e-01	0.000
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.999592e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999668e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.999669e-01	0.000
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.999718e-01	0.000
Amyloid fiber formation	R-HSA-977225	9.999718e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.999730e-01	0.000
Selenocysteine synthesis	R-HSA-2408557	9.999734e-01	0.000
Transmission across Chemical Synapses	R-HSA-112315	9.999743e-01	0.000
Viral mRNA Translation	R-HSA-192823	9.999787e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999801e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999822e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999859e-01	0.000
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.999861e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999899e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.999912e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999921e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.999944e-01	0.000
Mitochondrial protein degradation	R-HSA-9837999	9.999952e-01	0.000
Neuronal System	R-HSA-112316	9.999952e-01	0.000
Leishmania infection	R-HSA-9658195	9.999954e-01	0.000
Parasitic Infection Pathways	R-HSA-9824443	9.999954e-01	0.000
Potassium Channels	R-HSA-1296071	9.999966e-01	0.000
Post-translational protein modification	R-HSA-597592	9.999982e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999987e-01	0.000
Signaling by GPCR	R-HSA-372790	9.999990e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.999992e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999993e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.999994e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999995e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999995e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999998e-01	0.000
Immune System	R-HSA-168256	9.999998e-01	0.000
Neutrophil degranulation	R-HSA-6798695	9.999999e-01	0.000
Selenoamino acid metabolism	R-HSA-2408522	9.999999e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999999e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.999999e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	1.000000e+00	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	1.000000e+00	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	1.000000e+00	0.000
Extracellular matrix organization	R-HSA-1474244	1.000000e+00	0.000
Asparagine N-linked glycosylation	R-HSA-446203	1.000000e+00	0.000
Keratinization	R-HSA-6805567	1.000000e+00	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000
Sphingolipid metabolism	R-HSA-428157	1.000000e+00	0.000
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000
Respiratory electron transport	R-HSA-611105	1.000000e+00	0.000
Infectious disease	R-HSA-5663205	1.000000e+00	0.000
Translation	R-HSA-72766	1.000000e+00	0.000
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000
Disease	R-HSA-1643685	1.000000e+00	0.000
Innate Immune System	R-HSA-168249	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Drug ADME	R-HSA-9748784	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Chromatin organization	R-HSA-4839726	1.744102e-08	7.758
Chromatin modifying enzymes	R-HSA-3247509	2.149369e-08	7.668
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	9.396643e-07	6.027
Cell Cycle, Mitotic	R-HSA-69278	9.131244e-06	5.039
Apoptotic cleavage of cellular proteins	R-HSA-111465	3.660510e-05	4.436
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	4.214402e-05	4.375
Cell Cycle	R-HSA-1640170	8.949686e-05	4.048
M Phase	R-HSA-68886	1.097709e-04	3.960
MTOR signalling	R-HSA-165159	1.224245e-04	3.912
NRAGE signals death through JNK	R-HSA-193648	1.185489e-04	3.926
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.589851e-04	3.799
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	1.850553e-04	3.733
Signal Transduction	R-HSA-162582	2.213898e-04	3.655
Mitotic Prophase	R-HSA-68875	2.353594e-04	3.628
Gene expression (Transcription)	R-HSA-74160	2.600714e-04	3.585
HATs acetylate histones	R-HSA-3214847	2.855865e-04	3.544
p75 NTR receptor-mediated signalling	R-HSA-193704	2.855865e-04	3.544
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	3.226682e-04	3.491
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	3.142992e-04	3.503
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	5.246827e-04	3.280
RNA Polymerase II Transcription	R-HSA-73857	5.393751e-04	3.268
Transcriptional regulation by RUNX1	R-HSA-8878171	5.100971e-04	3.292
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	6.197656e-04	3.208
Cell-extracellular matrix interactions	R-HSA-446353	6.197656e-04	3.208
mRNA 3'-end processing	R-HSA-72187	6.748186e-04	3.171
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	6.977020e-04	3.156
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	7.937579e-04	3.100
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	7.937579e-04	3.100
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	7.522435e-04	3.124
Cell-Cell communication	R-HSA-1500931	8.854648e-04	3.053
Apoptotic execution phase	R-HSA-75153	8.627406e-04	3.064
PKMTs methylate histone lysines	R-HSA-3214841	1.093971e-03	2.961
Cell junction organization	R-HSA-446728	1.074670e-03	2.969
Epigenetic regulation of gene expression	R-HSA-212165	1.297848e-03	2.887
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.304112e-03	2.885
Transcriptional Regulation by TP53	R-HSA-3700989	1.506821e-03	2.822
mRNA Splicing - Major Pathway	R-HSA-72163	1.573577e-03	2.803
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	2.027371e-03	2.693
MITF-M-dependent gene expression	R-HSA-9856651	2.095541e-03	2.679
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	2.172601e-03	2.663
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	2.457147e-03	2.610
ATP-dependent chromatin remodelers	R-HSA-9932444	2.472295e-03	2.607
SWI/SNF chromatin remodelers	R-HSA-9932451	2.472295e-03	2.607
G alpha (12/13) signalling events	R-HSA-416482	2.297106e-03	2.639
RNA Polymerase II Transcription Termination	R-HSA-73856	2.292659e-03	2.640
Regulation of CDH1 Gene Transcription	R-HSA-9764560	2.454997e-03	2.610
TGFBR3 expression	R-HSA-9839394	2.472295e-03	2.607
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	2.906489e-03	2.537
Regulation of CDH1 Expression and Function	R-HSA-9764265	2.857355e-03	2.544
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	2.857355e-03	2.544
Death Receptor Signaling	R-HSA-73887	2.809858e-03	2.551
mRNA Splicing	R-HSA-72172	3.196743e-03	2.495
NGF-stimulated transcription	R-HSA-9031628	3.541902e-03	2.451
Nuclear Envelope Breakdown	R-HSA-2980766	3.882438e-03	2.411
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	4.397762e-03	2.357
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	4.397762e-03	2.357
Regulation of NFE2L2 gene expression	R-HSA-9818749	4.773881e-03	2.321
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	5.157161e-03	2.288
Mitotic Prometaphase	R-HSA-68877	5.337024e-03	2.273
mTORC1-mediated signalling	R-HSA-166208	5.330835e-03	2.273
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	5.084077e-03	2.294
Nuclear Receptor transcription pathway	R-HSA-383280	5.682716e-03	2.245
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	5.565537e-03	2.254
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	5.486330e-03	2.261
Regulation of PTEN gene transcription	R-HSA-8943724	5.486330e-03	2.261
Signaling by NTRK1 (TRKA)	R-HSA-187037	5.860068e-03	2.232
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	6.348247e-03	2.197
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	6.167461e-03	2.210
Mitotic Anaphase	R-HSA-68882	6.408713e-03	2.193
Mitotic Metaphase and Anaphase	R-HSA-2555396	6.768115e-03	2.170
MECP2 regulates transcription factors	R-HSA-9022707	6.870293e-03	2.163
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	6.910096e-03	2.161
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	7.622620e-03	2.118
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	8.103085e-03	2.091
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	8.103085e-03	2.091
Generic Transcription Pathway	R-HSA-212436	7.641368e-03	2.117
Depolymerization of the Nuclear Lamina	R-HSA-4419969	7.880415e-03	2.103
Diseases of mitotic cell cycle	R-HSA-9675126	8.106185e-03	2.091
Type I hemidesmosome assembly	R-HSA-446107	9.499251e-03	2.022
Formation of annular gap junctions	R-HSA-196025	9.499251e-03	2.022
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	9.203941e-03	2.036
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	9.228959e-03	2.035
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	9.286184e-03	2.032
Transcriptional Regulation by MECP2	R-HSA-8986944	8.739670e-03	2.059
Regulation of MECP2 expression and activity	R-HSA-9022692	9.371610e-03	2.028
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	8.648958e-03	2.063
Signaling by ALK in cancer	R-HSA-9700206	8.648958e-03	2.063
MITF-M-regulated melanocyte development	R-HSA-9730414	9.606476e-03	2.017
Diseases of Telomere Maintenance	R-HSA-9673013	9.864995e-03	2.006
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	9.864995e-03	2.006
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	9.864995e-03	2.006
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	9.864995e-03	2.006
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	9.864995e-03	2.006
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	9.864995e-03	2.006
Regulation of gap junction activity	R-HSA-191650	1.039258e-02	1.983
Inhibition of TSC complex formation by PKB	R-HSA-165181	1.039258e-02	1.983
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.024622e-02	1.989
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	1.059575e-02	1.975
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	1.059575e-02	1.975
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	1.154483e-02	1.938
DNA Damage Recognition in GG-NER	R-HSA-5696394	1.077855e-02	1.967
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	1.130745e-02	1.947
Oncogenic MAPK signaling	R-HSA-6802957	1.073269e-02	1.969
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	1.137959e-02	1.944
Gap junction degradation	R-HSA-190873	1.270742e-02	1.896
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	1.370867e-02	1.863
Signaling by NTRKs	R-HSA-166520	1.373741e-02	1.862
DCC mediated attractive signaling	R-HSA-418885	1.426086e-02	1.846
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	1.563808e-02	1.806
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	1.563808e-02	1.806
Regulation of gene expression in beta cells	R-HSA-210745	1.649161e-02	1.783
Translation initiation complex formation	R-HSA-72649	1.866041e-02	1.729
Mitotic Spindle Checkpoint	R-HSA-69618	2.030084e-02	1.692
Interleukin-37 signaling	R-HSA-9008059	1.888946e-02	1.724
HDACs deacetylate histones	R-HSA-3214815	2.054968e-02	1.687
Condensation of Prophase Chromosomes	R-HSA-2299718	2.068945e-02	1.684
Signaling by TGFBR3	R-HSA-9839373	2.068945e-02	1.684
Adherens junctions interactions	R-HSA-418990	2.085535e-02	1.681
Disorders of Developmental Biology	R-HSA-9675151	2.090988e-02	1.680
ChREBP activates metabolic gene expression	R-HSA-163765	2.101297e-02	1.678
Breakdown of the nuclear lamina	R-HSA-352238	2.114872e-02	1.675
Estrogen-dependent gene expression	R-HSA-9018519	2.170287e-02	1.663
Ribosomal scanning and start codon recognition	R-HSA-72702	2.257473e-02	1.646
Recycling pathway of L1	R-HSA-437239	2.291685e-02	1.640
Regulation of endogenous retroelements	R-HSA-9842860	2.328160e-02	1.633
Regulation of CDH1 Function	R-HSA-9764561	2.474049e-02	1.607
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	2.363698e-02	1.626
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	2.474049e-02	1.607
Signaling by Hippo	R-HSA-2028269	2.488254e-02	1.604
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	2.495136e-02	1.603
Amplification of signal from the kinetochores	R-HSA-141424	2.495136e-02	1.603
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	2.531049e-02	1.597
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	2.531135e-02	1.597
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	2.616802e-02	1.582
Regulation of TP53 Activity	R-HSA-5633007	2.670752e-02	1.573
Transport of the SLBP independent Mature mRNA	R-HSA-159227	2.752636e-02	1.560
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	3.091710e-02	1.510
HDMs demethylate histones	R-HSA-3214842	2.914505e-02	1.535
Membrane Trafficking	R-HSA-199991	3.149811e-02	1.502
Regulation of beta-cell development	R-HSA-186712	2.951298e-02	1.530
Apoptosis	R-HSA-109581	2.956227e-02	1.529
Interleukin-7 signaling	R-HSA-1266695	2.914505e-02	1.535
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	3.583438e-02	1.446
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	3.583438e-02	1.446
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	3.583438e-02	1.446
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	3.583438e-02	1.446
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	3.583438e-02	1.446
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	3.583438e-02	1.446
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	3.583438e-02	1.446
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	3.583438e-02	1.446
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	3.583438e-02	1.446
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	3.583438e-02	1.446
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	3.583438e-02	1.446
AKT phosphorylates targets in the cytosol	R-HSA-198323	3.201772e-02	1.495
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	3.201772e-02	1.495
Pervasive developmental disorders	R-HSA-9005895	3.201772e-02	1.495
Disorders of Nervous System Development	R-HSA-9697154	3.201772e-02	1.495
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	3.201772e-02	1.495
Nuclear import of Rev protein	R-HSA-180746	3.457731e-02	1.461
Cell-cell junction organization	R-HSA-421270	3.298810e-02	1.482
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	3.438413e-02	1.464
Formation of RNA Pol II elongation complex	R-HSA-112382	3.665781e-02	1.436
Rab regulation of trafficking	R-HSA-9007101	3.741521e-02	1.427
Transcriptional regulation of granulopoiesis	R-HSA-9616222	3.784007e-02	1.422
TBC/RABGAPs	R-HSA-8854214	3.798196e-02	1.420
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	3.857319e-02	1.414
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	3.857319e-02	1.414
SOS-mediated signalling	R-HSA-112412	3.884370e-02	1.411
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	3.884370e-02	1.411
RNA Polymerase II Transcription Elongation	R-HSA-75955	3.996284e-02	1.398
HIV elongation arrest and recovery	R-HSA-167287	4.240401e-02	1.373
Pausing and recovery of HIV elongation	R-HSA-167290	4.240401e-02	1.373
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	4.724016e-02	1.326
Vpr-mediated nuclear import of PICs	R-HSA-180910	4.724016e-02	1.326
Cellular response to heat stress	R-HSA-3371556	4.663310e-02	1.331
RNA Polymerase II Pre-transcription Events	R-HSA-674695	4.427194e-02	1.354
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	4.663310e-02	1.331
Ovarian tumor domain proteases	R-HSA-5689896	4.724016e-02	1.326
RMTs methylate histone arginines	R-HSA-3214858	4.171173e-02	1.380
ISG15 antiviral mechanism	R-HSA-1169408	4.747870e-02	1.324
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	4.754344e-02	1.323
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	4.903473e-02	1.309
Signaling by MRAS-complex mutants	R-HSA-9660537	4.903473e-02	1.309
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	4.903473e-02	1.309
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	4.903473e-02	1.309
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	4.988029e-02	1.302
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	4.988029e-02	1.302
Signaling downstream of RAS mutants	R-HSA-9649948	4.988029e-02	1.302
mRNA Splicing - Minor Pathway	R-HSA-72165	4.988029e-02	1.302
Signaling by RAS mutants	R-HSA-6802949	4.988029e-02	1.302
Signaling by EGFR	R-HSA-177929	5.106947e-02	1.292
Activation of the pre-replicative complex	R-HSA-68962	5.305162e-02	1.275
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	5.305162e-02	1.275
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	5.893160e-02	1.230
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	5.893160e-02	1.230
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	5.320512e-02	1.274
Separation of Sister Chromatids	R-HSA-2467813	5.441243e-02	1.264
Nucleotide Excision Repair	R-HSA-5696398	5.612358e-02	1.251
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	5.305162e-02	1.275
Downregulation of ERBB2 signaling	R-HSA-8863795	5.305162e-02	1.275
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	5.338181e-02	1.273
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	5.305162e-02	1.275
VEGFA-VEGFR2 Pathway	R-HSA-4420097	5.994617e-02	1.222
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	5.338181e-02	1.273
Signaling by PDGFR in disease	R-HSA-9671555	5.177679e-02	1.286
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	5.203939e-02	1.284
Unwinding of DNA	R-HSA-176974	6.039120e-02	1.219
Inactivation of CDC42 and RAC1	R-HSA-428543	6.039120e-02	1.219
GP1b-IX-V activation signalling	R-HSA-430116	6.039120e-02	1.219
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	6.248939e-02	1.204
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	6.248939e-02	1.204
Interactions of Vpr with host cellular proteins	R-HSA-176033	6.252738e-02	1.204
Interactions of Rev with host cellular proteins	R-HSA-177243	6.252738e-02	1.204
HIV Life Cycle	R-HSA-162587	6.528191e-02	1.185
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	6.587148e-02	1.181
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	6.594098e-02	1.181
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	7.112153e-02	1.148
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	7.331035e-02	1.135
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	7.331035e-02	1.135
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	7.285583e-02	1.138
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	7.285583e-02	1.138
Processing of Intronless Pre-mRNAs	R-HSA-77595	7.185406e-02	1.144
Deadenylation of mRNA	R-HSA-429947	7.375515e-02	1.132
IPs transport between nucleus and cytosol	R-HSA-1855170	7.181168e-02	1.144
Striated Muscle Contraction	R-HSA-390522	7.881048e-02	1.103
Signaling by RAF1 mutants	R-HSA-9656223	7.421370e-02	1.130
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	6.767364e-02	1.170
Signaling by ERBB2	R-HSA-1227986	6.877348e-02	1.163
MAP2K and MAPK activation	R-HSA-5674135	7.421370e-02	1.130
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	6.947427e-02	1.158
Signal attenuation	R-HSA-74749	7.285583e-02	1.138
Neurexins and neuroligins	R-HSA-6794361	8.027744e-02	1.095
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	6.822030e-02	1.166
CD209 (DC-SIGN) signaling	R-HSA-5621575	7.375515e-02	1.132
S Phase	R-HSA-69242	7.186945e-02	1.143
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	7.331035e-02	1.135
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	7.003512e-02	1.155
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	7.881048e-02	1.103
Transcriptional regulation by small RNAs	R-HSA-5578749	7.683849e-02	1.114
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	7.890261e-02	1.103
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	7.181168e-02	1.144
Heme signaling	R-HSA-9707616	7.890261e-02	1.103
Programmed Cell Death	R-HSA-5357801	7.750624e-02	1.111
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	8.189019e-02	1.087
Specification of primordial germ cells	R-HSA-9827857	8.189019e-02	1.087
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	8.351926e-02	1.078
Adipogenesis	R-HSA-9843745	8.360503e-02	1.078
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	8.428965e-02	1.074
Loss of Nlp from mitotic centrosomes	R-HSA-380259	8.428965e-02	1.074
RAF activation	R-HSA-5673000	8.617853e-02	1.065
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	8.621865e-02	1.064
Circadian clock	R-HSA-9909396	8.735585e-02	1.059
Late Phase of HIV Life Cycle	R-HSA-162599	8.993476e-02	1.046
Myogenesis	R-HSA-525793	9.081825e-02	1.042
Non-integrin membrane-ECM interactions	R-HSA-3000171	9.213231e-02	1.036
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	9.257629e-02	1.034
Polo-like kinase mediated events	R-HSA-156711	9.257629e-02	1.034
Mismatch Repair	R-HSA-5358508	9.257629e-02	1.034
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	9.257629e-02	1.034
Metabolism of RNA	R-HSA-8953854	9.263181e-02	1.033
Clathrin-mediated endocytosis	R-HSA-8856828	9.371237e-02	1.028
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	9.391167e-02	1.027
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	9.519314e-02	1.021
IRS activation	R-HSA-74713	9.519314e-02	1.021
G2 Phase	R-HSA-68911	9.519314e-02	1.021
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	9.519314e-02	1.021
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	1.000486e-01	1.000
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	1.000486e-01	1.000
Signaling by VEGF	R-HSA-194138	1.007495e-01	0.997
Activation of RAC1	R-HSA-428540	1.008374e-01	0.996
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	1.011739e-01	0.995
Noncanonical activation of NOTCH3	R-HSA-9017802	1.186519e-01	0.926
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	1.186519e-01	0.926
Repression of WNT target genes	R-HSA-4641265	1.162035e-01	0.935
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	1.162035e-01	0.935
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	1.038871e-01	0.983
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.157942e-01	0.936
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	1.086483e-01	0.964
AURKA Activation by TPX2	R-HSA-8854518	1.017381e-01	0.993
snRNP Assembly	R-HSA-191859	1.270415e-01	0.896
Metabolism of non-coding RNA	R-HSA-194441	1.270415e-01	0.896
Formation of definitive endoderm	R-HSA-9823730	1.157942e-01	0.936
VxPx cargo-targeting to cilium	R-HSA-5620916	1.157942e-01	0.936
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	1.162035e-01	0.935
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	1.186519e-01	0.926
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.056410e-01	0.976
RUNX3 regulates NOTCH signaling	R-HSA-8941856	1.162035e-01	0.935
RNA Polymerase I Transcription	R-HSA-73864	1.091137e-01	0.962
Deadenylation-dependent mRNA decay	R-HSA-429914	1.270415e-01	0.896
Negative feedback regulation of MAPK pathway	R-HSA-5674499	1.186519e-01	0.926
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	1.162035e-01	0.935
ESR-mediated signaling	R-HSA-8939211	1.032200e-01	0.986
TCF dependent signaling in response to WNT	R-HSA-201681	1.180152e-01	0.928
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	1.186519e-01	0.926
Deubiquitination	R-HSA-5688426	1.235543e-01	0.908
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	1.186519e-01	0.926
Pre-NOTCH Transcription and Translation	R-HSA-1912408	1.267921e-01	0.897
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	1.279567e-01	0.893
Transcriptional Regulation by E2F6	R-HSA-8953750	1.283672e-01	0.892
Signaling by ALK	R-HSA-201556	1.283672e-01	0.892
NS1 Mediated Effects on Host Pathways	R-HSA-168276	1.283672e-01	0.892
Activation of BH3-only proteins	R-HSA-114452	1.303809e-01	0.885
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	1.371887e-01	0.863
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	1.371887e-01	0.863
Defective Mismatch Repair Associated With MLH1	R-HSA-5545483	1.371887e-01	0.863
Defective Mismatch Repair Associated With PMS2	R-HSA-5632987	1.371887e-01	0.863
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	1.985605e-01	0.702
Signaling by TCF7L2 mutants	R-HSA-5339700	1.985605e-01	0.702
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	1.985605e-01	0.702
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	1.985605e-01	0.702
Defective MMADHC causes MMAHCD	R-HSA-3359473	1.985605e-01	0.702
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	1.985605e-01	0.702
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	2.555704e-01	0.592
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	2.555704e-01	0.592
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	2.555704e-01	0.592
RUNX3 regulates WNT signaling	R-HSA-8951430	1.689992e-01	0.772
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	1.689992e-01	0.772
NOSTRIN mediated eNOS trafficking	R-HSA-203641	1.689992e-01	0.772
IFNG signaling activates MAPKs	R-HSA-9732724	1.689992e-01	0.772
Cohesin Loading onto Chromatin	R-HSA-2470946	1.689992e-01	0.772
Defective MMACHC causes MAHCC	R-HSA-3359474	3.085280e-01	0.511
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	3.085280e-01	0.511
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	3.085280e-01	0.511
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	3.085280e-01	0.511
Invadopodia formation	R-HSA-8941237	3.085280e-01	0.511
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	2.221280e-01	0.653
AKT phosphorylates targets in the nucleus	R-HSA-198693	2.221280e-01	0.653
PLCG1 events in ERBB2 signaling	R-HSA-1251932	3.577213e-01	0.446
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	3.577213e-01	0.446
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	3.577213e-01	0.446
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	R-HSA-2644607	3.577213e-01	0.446
Defective LFNG causes SCDO3	R-HSA-5083630	3.577213e-01	0.446
GRB7 events in ERBB2 signaling	R-HSA-1306955	3.577213e-01	0.446
FBXW7 Mutants and NOTCH1 in Cancer	R-HSA-2644605	3.577213e-01	0.446
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	3.577213e-01	0.446
Erythropoietin activates RAS	R-HSA-9027284	1.668342e-01	0.778
Activation of BAD and translocation to mitochondria	R-HSA-111447	1.668342e-01	0.778
DNA replication initiation	R-HSA-68952	2.491842e-01	0.603
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	2.035453e-01	0.691
NOSIP mediated eNOS trafficking	R-HSA-203754	4.034175e-01	0.394
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	4.034175e-01	0.394
Condensation of Prometaphase Chromosomes	R-HSA-2514853	3.034143e-01	0.518
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	1.526414e-01	0.816
Signaling by ERBB2 ECD mutants	R-HSA-9665348	2.418821e-01	0.616
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	1.378196e-01	0.861
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	2.129937e-01	0.672
SHC-related events triggered by IGF1R	R-HSA-2428933	3.303103e-01	0.481
Polymerase switching	R-HSA-69091	3.303103e-01	0.481
Leading Strand Synthesis	R-HSA-69109	3.303103e-01	0.481
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	4.458652e-01	0.351
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	4.458652e-01	0.351
Nef Mediated CD8 Down-regulation	R-HSA-182218	4.458652e-01	0.351
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	4.458652e-01	0.351
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	4.458652e-01	0.351
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	4.458652e-01	0.351
IkBA variant leads to EDA-ID	R-HSA-5603029	4.458652e-01	0.351
Interaction between L1 and Ankyrins	R-HSA-445095	2.284125e-01	0.641
HSF1-dependent transactivation	R-HSA-3371571	1.501886e-01	0.823
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	2.440994e-01	0.612
Formation of the Early Elongation Complex	R-HSA-113418	2.440994e-01	0.612
Activation of AMPK downstream of NMDARs	R-HSA-9619483	2.440994e-01	0.612
G1/S-Specific Transcription	R-HSA-69205	2.142807e-01	0.669
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.497485e-01	0.825
Signaling by ERBB2 in Cancer	R-HSA-1227990	2.761263e-01	0.559
SHC1 events in ERBB2 signaling	R-HSA-1250196	2.761263e-01	0.559
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	3.211366e-01	0.493
Removal of the Flap Intermediate	R-HSA-69166	3.831117e-01	0.417
Retrograde neurotrophin signalling	R-HSA-177504	3.831117e-01	0.417
Signaling by LTK in cancer	R-HSA-9842640	4.852950e-01	0.314
Erythropoietin activates STAT5	R-HSA-9027283	4.852950e-01	0.314
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	4.852950e-01	0.314
STAT5 Activation	R-HSA-9645135	4.852950e-01	0.314
Autointegration results in viral DNA circles	R-HSA-177539	4.852950e-01	0.314
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	4.852950e-01	0.314
Centrosome maturation	R-HSA-380287	1.652340e-01	0.782
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	2.354856e-01	0.628
Inhibition of DNA recombination at telomere	R-HSA-9670095	2.682733e-01	0.571
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	2.822267e-01	0.549
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	3.610507e-01	0.442
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	3.610507e-01	0.442
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	1.850980e-01	0.733
Developmental Lineages of the Mammary Gland	R-HSA-9924644	2.422717e-01	0.616
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	3.808908e-01	0.419
TRAF6 mediated NF-kB activation	R-HSA-933542	3.808908e-01	0.419
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	4.340415e-01	0.362
Phosphorylation of the APC/C	R-HSA-176412	4.340415e-01	0.362
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	4.340415e-01	0.362
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	5.219213e-01	0.282
Recycling of eIF2:GDP	R-HSA-72731	5.219213e-01	0.282
Disinhibition of SNARE formation	R-HSA-114516	5.219213e-01	0.282
Dual Incision in GG-NER	R-HSA-5696400	3.583262e-01	0.446
G beta:gamma signalling through CDC42	R-HSA-8964616	4.586476e-01	0.339
GRB2 events in ERBB2 signaling	R-HSA-1963640	4.586476e-01	0.339
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	3.352227e-01	0.475
PRC2 methylates histones and DNA	R-HSA-212300	3.913663e-01	0.407
Cap-dependent Translation Initiation	R-HSA-72737	2.571396e-01	0.590
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	2.762295e-01	0.559
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	5.059232e-01	0.296
G beta:gamma signalling through PLC beta	R-HSA-418217	5.059232e-01	0.296
Signaling by Erythropoietin	R-HSA-9006335	4.772341e-01	0.321
Signaling by ERBB2 KD Mutants	R-HSA-9664565	4.772341e-01	0.321
DNA methylation	R-HSA-5334118	4.772341e-01	0.321
Attenuation phase	R-HSA-3371568	4.564708e-01	0.341
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	4.564708e-01	0.341
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	4.135496e-01	0.383
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	5.285322e-01	0.277
Meiotic synapsis	R-HSA-1221632	4.681296e-01	0.330
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	4.881610e-01	0.311
HIV Transcription Initiation	R-HSA-167161	4.881610e-01	0.311
RNA Polymerase II Transcription Initiation	R-HSA-75953	4.881610e-01	0.311
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	5.037209e-01	0.298
RNA Polymerase II Promoter Escape	R-HSA-73776	5.190684e-01	0.285
HCMV Early Events	R-HSA-9609690	5.200501e-01	0.284
Transcription of the HIV genome	R-HSA-167172	2.034816e-01	0.691
Signaling by NOTCH1	R-HSA-1980143	4.254057e-01	0.371
Eukaryotic Translation Initiation	R-HSA-72613	2.571396e-01	0.590
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	1.480042e-01	0.830
HIV Transcription Elongation	R-HSA-167169	2.682733e-01	0.571
VEGFR2 mediated vascular permeability	R-HSA-5218920	4.724050e-01	0.326
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	4.724050e-01	0.326
Ephrin signaling	R-HSA-3928664	2.418821e-01	0.616
mRNA Capping	R-HSA-72086	4.772341e-01	0.321
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	4.581657e-01	0.339
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	2.958704e-01	0.529
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	4.581657e-01	0.339
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	4.581657e-01	0.339
G0 and Early G1	R-HSA-1538133	3.087790e-01	0.510
IGF1R signaling cascade	R-HSA-2428924	2.844438e-01	0.546
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	2.682733e-01	0.571
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	4.749508e-01	0.323
Aggrephagy	R-HSA-9646399	4.564708e-01	0.341
Processive synthesis on the lagging strand	R-HSA-69183	4.088450e-01	0.388
Nephrin family interactions	R-HSA-373753	2.812567e-01	0.551
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	2.274585e-01	0.643
Interleukin receptor SHC signaling	R-HSA-912526	3.610507e-01	0.442
Integrin signaling	R-HSA-354192	3.252521e-01	0.488
IRS-related events triggered by IGF1R	R-HSA-2428928	2.508718e-01	0.601
Cyclin D associated events in G1	R-HSA-69231	1.895553e-01	0.722
G1 Phase	R-HSA-69236	1.895553e-01	0.722
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	3.740053e-01	0.427
TRAF3-dependent IRF activation pathway	R-HSA-918233	2.035453e-01	0.691
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	2.698533e-01	0.569
Activated NTRK3 signals through PI3K	R-HSA-9603381	1.689992e-01	0.772
Activation of PUMA and translocation to mitochondria	R-HSA-139915	1.689992e-01	0.772
PI3K/AKT activation	R-HSA-198203	2.491842e-01	0.603
MET activates RAP1 and RAC1	R-HSA-8875555	2.491842e-01	0.603
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	2.763294e-01	0.559
DNA strand elongation	R-HSA-69190	1.526414e-01	0.816
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	2.544784e-01	0.594
Formation of Incision Complex in GG-NER	R-HSA-5696395	2.682733e-01	0.571
SIRT1 negatively regulates rRNA expression	R-HSA-427359	4.078024e-01	0.390
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	3.583262e-01	0.446
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	2.182390e-01	0.661
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	3.352227e-01	0.475
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	3.824394e-01	0.417
IRS-mediated signalling	R-HSA-112399	5.231930e-01	0.281
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	2.248247e-01	0.648
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	2.221280e-01	0.653
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	4.034175e-01	0.394
NF-kB is activated and signals survival	R-HSA-209560	3.034143e-01	0.518
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	3.303103e-01	0.481
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	4.458652e-01	0.351
Formation of axial mesoderm	R-HSA-9796292	3.569072e-01	0.447
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	1.822136e-01	0.739
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	3.258989e-01	0.487
Trafficking of AMPA receptors	R-HSA-399719	5.138213e-01	0.289
Synthesis of DNA	R-HSA-69239	3.834227e-01	0.416
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	2.698533e-01	0.569
Nuclear RNA decay	R-HSA-9930044	1.643274e-01	0.784
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	1.497485e-01	0.825
UCH proteinases	R-HSA-5689603	2.832751e-01	0.548
Activation of HOX genes during differentiation	R-HSA-5619507	4.851200e-01	0.314
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	4.851200e-01	0.314
NoRC negatively regulates rRNA expression	R-HSA-427413	3.660619e-01	0.436
Gap junction trafficking and regulation	R-HSA-157858	2.474726e-01	0.606
Nuclear events mediated by NFE2L2	R-HSA-9759194	2.981445e-01	0.526
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	2.129937e-01	0.672
MET activates RAS signaling	R-HSA-8851805	3.303103e-01	0.481
RNA Polymerase I Promoter Clearance	R-HSA-73854	1.732501e-01	0.761
G1/S Transition	R-HSA-69206	3.407894e-01	0.468
PTK6 Expression	R-HSA-8849473	1.689992e-01	0.772
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	4.034175e-01	0.394
Activation of AKT2	R-HSA-165158	4.034175e-01	0.394
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	3.034143e-01	0.518
RNA Polymerase I Transcription Initiation	R-HSA-73762	1.680177e-01	0.775
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	2.762295e-01	0.559
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	4.826195e-01	0.316
MET promotes cell motility	R-HSA-8875878	4.241477e-01	0.372
Golgi-to-ER retrograde transport	R-HSA-8856688	3.018976e-01	0.520
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	5.059232e-01	0.296
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	4.956940e-01	0.305
DNA Double Strand Break Response	R-HSA-5693606	4.769638e-01	0.322
Defective pyroptosis	R-HSA-9710421	5.190684e-01	0.285
Transcriptional regulation by RUNX3	R-HSA-8878159	2.789468e-01	0.554
DNA Double-Strand Break Repair	R-HSA-5693532	3.845429e-01	0.415
KEAP1-NFE2L2 pathway	R-HSA-9755511	4.776778e-01	0.321
DNA Replication Pre-Initiation	R-HSA-69002	1.891991e-01	0.723
Meiosis	R-HSA-1500620	3.805362e-01	0.420
p75NTR signals via NF-kB	R-HSA-193639	1.668342e-01	0.778
Frs2-mediated activation	R-HSA-170968	3.569072e-01	0.447
Signaling by FLT3 fusion proteins	R-HSA-9703465	2.129937e-01	0.672
Downregulation of ERBB4 signaling	R-HSA-1253288	1.953336e-01	0.709
Lipophagy	R-HSA-9613354	2.221280e-01	0.653
G-protein beta:gamma signalling	R-HSA-397795	1.643274e-01	0.784
WNT5A-dependent internalization of FZD4	R-HSA-5099900	4.340415e-01	0.362
Nef Mediated CD4 Down-regulation	R-HSA-167590	5.219213e-01	0.282
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	4.826195e-01	0.316
Elevation of cytosolic Ca2+ levels	R-HSA-139853	4.826195e-01	0.316
Switching of origins to a post-replicative state	R-HSA-69052	3.897970e-01	0.409
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	5.285322e-01	0.277
EPH-Ephrin signaling	R-HSA-2682334	3.412684e-01	0.467
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	3.034143e-01	0.518
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	1.378196e-01	0.861
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	1.378196e-01	0.861
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	2.812567e-01	0.551
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	4.852950e-01	0.314
Signaling by SCF-KIT	R-HSA-1433557	5.190684e-01	0.285
Homology Directed Repair	R-HSA-5693538	5.093218e-01	0.293
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	2.225484e-01	0.653
p75NTR recruits signalling complexes	R-HSA-209543	3.303103e-01	0.481
Maternal to zygotic transition (MZT)	R-HSA-9816359	1.425443e-01	0.846
Post NMDA receptor activation events	R-HSA-438064	2.813516e-01	0.551
DNA Replication	R-HSA-69306	4.944429e-01	0.306
Prolonged ERK activation events	R-HSA-169893	4.340415e-01	0.362
FGFR1 mutant receptor activation	R-HSA-1839124	3.252521e-01	0.488
HIV Infection	R-HSA-162906	2.148428e-01	0.668
Signaling by FGFR1 in disease	R-HSA-5655302	2.963155e-01	0.528
DNA Repair	R-HSA-73894	2.483975e-01	0.605
Formation of editosomes by ADAR proteins	R-HSA-77042	1.371887e-01	0.863
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	1.985605e-01	0.702
Transport of connexins along the secretory pathway	R-HSA-190827	1.985605e-01	0.702
mRNA Editing: A to I Conversion	R-HSA-75064	2.555704e-01	0.592
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	2.555704e-01	0.592
C6 deamination of adenosine	R-HSA-75102	2.555704e-01	0.592
MET interacts with TNS proteins	R-HSA-8875513	3.085280e-01	0.511
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	3.085280e-01	0.511
Regulation of KIT signaling	R-HSA-1433559	1.492842e-01	0.826
AKT-mediated inactivation of FOXO1A	R-HSA-211163	3.577213e-01	0.446
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	2.491842e-01	0.603
Regulation of gene expression in early pancreatic precursor cells	R-HSA-210747	2.763294e-01	0.559
Reelin signalling pathway	R-HSA-8866376	4.034175e-01	0.394
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	4.034175e-01	0.394
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	1.687318e-01	0.773
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	1.831146e-01	0.737
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	1.831146e-01	0.737
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	3.034143e-01	0.518
Mitotic Telophase/Cytokinesis	R-HSA-68884	3.034143e-01	0.518
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	2.418821e-01	0.616
PDE3B signalling	R-HSA-165160	4.458652e-01	0.351
PKB-mediated events	R-HSA-109703	4.458652e-01	0.351
Synthesis of PS	R-HSA-1483101	4.458652e-01	0.351
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	3.569072e-01	0.447
Viral Messenger RNA Synthesis	R-HSA-168325	1.425474e-01	0.846
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	2.007036e-01	0.697
G2/M DNA replication checkpoint	R-HSA-69478	4.852950e-01	0.314
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	3.417784e-01	0.466
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	4.340415e-01	0.362
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	4.586476e-01	0.339
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	3.151242e-01	0.502
RNA Polymerase I Promoter Opening	R-HSA-73728	4.394144e-01	0.357
Presynaptic function of Kainate receptors	R-HSA-500657	5.059232e-01	0.296
PKA activation in glucagon signalling	R-HSA-164378	5.059232e-01	0.296
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	4.258205e-01	0.371
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	4.540440e-01	0.343
Orc1 removal from chromatin	R-HSA-68949	4.540440e-01	0.343
E2F mediated regulation of DNA replication	R-HSA-113510	5.285322e-01	0.277
Signaling by FGFR2 IIIa TM	R-HSA-8851708	5.285322e-01	0.277
Cilium Assembly	R-HSA-5617833	4.750259e-01	0.323
Assembly of the pre-replicative complex	R-HSA-68867	2.344869e-01	0.630
Organelle biogenesis and maintenance	R-HSA-1852241	2.399087e-01	0.620
Chaperone Mediated Autophagy	R-HSA-9613829	5.059232e-01	0.296
Signalling to ERKs	R-HSA-187687	3.748651e-01	0.426
MAP kinase activation	R-HSA-450294	3.999452e-01	0.398
Pre-NOTCH Expression and Processing	R-HSA-1912422	3.202542e-01	0.495
Selective autophagy	R-HSA-9663891	2.911465e-01	0.536
Vesicle-mediated transport	R-HSA-5653656	4.227039e-01	0.374
EPHB-mediated forward signaling	R-HSA-3928662	1.895553e-01	0.722
Listeria monocytogenes entry into host cells	R-HSA-8876384	3.211366e-01	0.493
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	5.138213e-01	0.289
Mitotic G2-G2/M phases	R-HSA-453274	1.988901e-01	0.701
EGFR downregulation	R-HSA-182971	2.923923e-01	0.534
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	4.088450e-01	0.388
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	4.201119e-01	0.377
Signaling by NOTCH	R-HSA-157118	4.560615e-01	0.341
Mitochondrial biogenesis	R-HSA-1592230	1.769192e-01	0.752
Termination of translesion DNA synthesis	R-HSA-5656169	4.772341e-01	0.321
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	5.285322e-01	0.277
G2/M Transition	R-HSA-69275	3.472753e-01	0.459
Receptor Mediated Mitophagy	R-HSA-8934903	2.491842e-01	0.603
Acetylcholine regulates insulin secretion	R-HSA-399997	2.035453e-01	0.691
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	4.034175e-01	0.394
Rap1 signalling	R-HSA-392517	2.614744e-01	0.583
ERK/MAPK targets	R-HSA-198753	3.011644e-01	0.521
NRIF signals cell death from the nucleus	R-HSA-205043	3.831117e-01	0.417
Interleukin-17 signaling	R-HSA-448424	5.144252e-01	0.289
Autophagy	R-HSA-9612973	5.193586e-01	0.285
FLT3 signaling in disease	R-HSA-9682385	3.913663e-01	0.407
Cellular Senescence	R-HSA-2559583	2.235607e-01	0.651
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.480042e-01	0.830
Negative regulation of MAPK pathway	R-HSA-5675221	4.881610e-01	0.311
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	4.544908e-01	0.342
Macroautophagy	R-HSA-1632852	3.846161e-01	0.415
Regulated proteolysis of p75NTR	R-HSA-193692	2.221280e-01	0.653
Activation of NOXA and translocation to mitochondria	R-HSA-111448	3.577213e-01	0.446
Signaling by LTK	R-HSA-9842663	3.303103e-01	0.481
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	3.411163e-01	0.467
Resolution of Abasic Sites (AP sites)	R-HSA-73933	2.822267e-01	0.549
Signaling by WNT	R-HSA-195721	4.018659e-01	0.396
Protein-protein interactions at synapses	R-HSA-6794362	2.525631e-01	0.598
Signaling by MET	R-HSA-6806834	2.070110e-01	0.684
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	2.620524e-01	0.582
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	2.600165e-01	0.585
Acyl chain remodelling of PS	R-HSA-1482801	4.005915e-01	0.397
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	4.496903e-01	0.347
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	3.211366e-01	0.493
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	4.586476e-01	0.339
PIP3 activates AKT signaling	R-HSA-1257604	2.415691e-01	0.617
Kinesins	R-HSA-983189	3.869764e-01	0.412
Influenza Viral RNA Transcription and Replication	R-HSA-168273	5.110887e-01	0.292
Developmental Biology	R-HSA-1266738	4.845770e-01	0.315
Axon guidance	R-HSA-422475	1.814575e-01	0.741
Intracellular signaling by second messengers	R-HSA-9006925	2.848390e-01	0.545
Host Interactions of HIV factors	R-HSA-162909	4.396847e-01	0.357
Nervous system development	R-HSA-9675108	1.779468e-01	0.750
Semaphorin interactions	R-HSA-373755	2.731270e-01	0.564
Oligomerization of connexins into connexons	R-HSA-190704	1.985605e-01	0.702
Sensory perception of sour taste	R-HSA-9729555	3.577213e-01	0.446
Signalling to p38 via RIT and RIN	R-HSA-187706	4.458652e-01	0.351
RET signaling	R-HSA-8853659	2.142807e-01	0.669
Integration of viral DNA into host genomic DNA	R-HSA-175567	4.852950e-01	0.314
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	4.340415e-01	0.362
VLDL clearance	R-HSA-8964046	5.219213e-01	0.282
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	3.583262e-01	0.446
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	3.096276e-01	0.509
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	4.586476e-01	0.339
Evasion by RSV of host interferon responses	R-HSA-9833109	5.138213e-01	0.289
Reproduction	R-HSA-1474165	3.933115e-01	0.405
Signaling by NTRK3 (TRKC)	R-HSA-9034015	3.211366e-01	0.493
Oncogene Induced Senescence	R-HSA-2559585	3.748651e-01	0.426
L1CAM interactions	R-HSA-373760	2.571396e-01	0.590
Smooth Muscle Contraction	R-HSA-445355	4.681296e-01	0.330
Downstream signal transduction	R-HSA-186763	5.138213e-01	0.289
Transcriptional Regulation by VENTX	R-HSA-8853884	2.822267e-01	0.549
Sema4D in semaphorin signaling	R-HSA-400685	4.005915e-01	0.397
FLT3 Signaling	R-HSA-9607240	4.724050e-01	0.326
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	1.323798e-01	0.878
Carnitine shuttle	R-HSA-200425	3.610507e-01	0.442
FOXO-mediated transcription	R-HSA-9614085	4.235914e-01	0.373
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	4.584652e-01	0.339
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.433522e-01	0.844
Histamine receptors	R-HSA-390650	3.085280e-01	0.511
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	1.668342e-01	0.778
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	2.491842e-01	0.603
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	2.034816e-01	0.691
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	3.252521e-01	0.488
Regulation of PD-L1(CD274) expression	R-HSA-9909648	3.391317e-01	0.470
PI3K/AKT Signaling in Cancer	R-HSA-2219528	5.093218e-01	0.293
Spry regulation of FGF signaling	R-HSA-1295596	4.088450e-01	0.388
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	4.025757e-01	0.395
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.418017e-01	0.848
Netrin-1 signaling	R-HSA-373752	3.391669e-01	0.470
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	4.201119e-01	0.377
Intrinsic Pathway for Apoptosis	R-HSA-109606	3.352227e-01	0.475
Signaling by FGFR in disease	R-HSA-1226099	4.016765e-01	0.396
Displacement of DNA glycosylase by APEX1	R-HSA-110357	1.689992e-01	0.772
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	1.689992e-01	0.772
The NLRP1 inflammasome	R-HSA-844455	3.085280e-01	0.511
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	2.221280e-01	0.653
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	1.849479e-01	0.733
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	1.475869e-01	0.831
CLEC7A/inflammasome pathway	R-HSA-5660668	4.458652e-01	0.351
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	3.569072e-01	0.447
CREB phosphorylation	R-HSA-199920	4.852950e-01	0.314
NADPH regeneration	R-HSA-389542	4.852950e-01	0.314
Regulation of PTEN localization	R-HSA-8948747	5.219213e-01	0.282
Netrin mediated repulsion signals	R-HSA-418886	5.219213e-01	0.282
Signaling by ROBO receptors	R-HSA-376176	1.524236e-01	0.817
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	4.403781e-01	0.356
SARS-CoV-2-host interactions	R-HSA-9705683	2.921978e-01	0.534
PI Metabolism	R-HSA-1483255	3.256161e-01	0.487
Zygotic genome activation (ZGA)	R-HSA-9819196	3.011644e-01	0.521
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	5.162812e-01	0.287
Sensory processing of sound	R-HSA-9659379	3.151242e-01	0.502
Neurodegenerative Diseases	R-HSA-8863678	1.831146e-01	0.737
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.831146e-01	0.737
Cell Cycle Checkpoints	R-HSA-69620	1.847195e-01	0.733
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	1.547712e-01	0.810
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	3.411163e-01	0.467
Transcriptional regulation by RUNX2	R-HSA-8878166	5.187794e-01	0.285
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	2.284125e-01	0.641
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	4.258205e-01	0.371
Signaling by PTK6	R-HSA-8848021	4.258205e-01	0.371
DNA Damage Bypass	R-HSA-73893	4.112504e-01	0.386
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	1.953336e-01	0.709
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	4.034175e-01	0.394
Regulation of CDH19 Expression and Function	R-HSA-9764302	4.458652e-01	0.351
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	3.011644e-01	0.521
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	2.120852e-01	0.673
IRF3-mediated induction of type I IFN	R-HSA-3270619	4.088450e-01	0.388
Signaling by NOTCH4	R-HSA-9013694	2.625332e-01	0.581
FOXO-mediated transcription of cell death genes	R-HSA-9614657	5.059232e-01	0.296
Diseases of programmed cell death	R-HSA-9645723	4.246142e-01	0.372
Inositol phosphate metabolism	R-HSA-1483249	2.108748e-01	0.676
PTEN Regulation	R-HSA-6807070	1.844726e-01	0.734
Interleukin-15 signaling	R-HSA-8983432	3.303103e-01	0.481
Josephin domain DUBs	R-HSA-5689877	2.491842e-01	0.603
Signaling by NOTCH3	R-HSA-9012852	4.959434e-01	0.305
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	5.037209e-01	0.298
SARS-CoV-1-host interactions	R-HSA-9692914	2.591672e-01	0.586
tRNA processing in the nucleus	R-HSA-6784531	4.128977e-01	0.384
Potential therapeutics for SARS	R-HSA-9679191	4.692589e-01	0.329
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	4.956940e-01	0.305
OAS antiviral response	R-HSA-8983711	3.303103e-01	0.481
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	1.979963e-01	0.703
Gene Silencing by RNA	R-HSA-211000	2.676540e-01	0.572
Nephron development	R-HSA-9831926	5.059232e-01	0.296
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.895553e-01	0.722
Miscellaneous transport and binding events	R-HSA-5223345	3.417784e-01	0.466
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	4.586476e-01	0.339
Signaling by Leptin	R-HSA-2586552	2.491842e-01	0.603
STING mediated induction of host immune responses	R-HSA-1834941	5.285322e-01	0.277
GAB1 signalosome	R-HSA-180292	5.059232e-01	0.296
Maturation of replicase proteins	R-HSA-9694301	5.219213e-01	0.282
Gap junction trafficking	R-HSA-190828	5.341884e-01	0.272
Dual incision in TC-NER	R-HSA-6782135	5.365765e-01	0.270
Chromosome Maintenance	R-HSA-73886	5.375178e-01	0.270
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	5.388211e-01	0.269
Telomere Maintenance	R-HSA-157579	5.429791e-01	0.265
Signaling by Nuclear Receptors	R-HSA-9006931	5.454005e-01	0.263
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	5.489972e-01	0.260
Activation of ATR in response to replication stress	R-HSA-176187	5.489972e-01	0.260
Assembly of the ORC complex at the origin of replication	R-HSA-68616	5.489972e-01	0.260
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	5.490674e-01	0.260
Platelet Aggregation (Plug Formation)	R-HSA-76009	5.490674e-01	0.260
Co-inhibition by PD-1	R-HSA-389948	5.495055e-01	0.260
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	5.497851e-01	0.260
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	5.504276e-01	0.259
Co-inhibition by CTLA4	R-HSA-389513	5.504276e-01	0.259
Signaling by NODAL	R-HSA-1181150	5.504276e-01	0.259
Negative regulation of MET activity	R-HSA-6807004	5.504276e-01	0.259
Protein hydroxylation	R-HSA-9629569	5.504276e-01	0.259
Signaling by TGFB family members	R-HSA-9006936	5.520118e-01	0.258
SARS-CoV Infections	R-HSA-9679506	5.523477e-01	0.258
RSK activation	R-HSA-444257	5.559433e-01	0.255
Activation of RAS in B cells	R-HSA-1169092	5.559433e-01	0.255
Myoclonic epilepsy of Lafora	R-HSA-3785653	5.559433e-01	0.255
MET receptor recycling	R-HSA-8875656	5.559433e-01	0.255
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	5.559433e-01	0.255
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	5.559433e-01	0.255
Adrenoceptors	R-HSA-390696	5.559433e-01	0.255
Axonal growth inhibition (RHOA activation)	R-HSA-193634	5.559433e-01	0.255
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	5.559433e-01	0.255
TGFBR3 PTM regulation	R-HSA-9839383	5.559433e-01	0.255
Alpha-defensins	R-HSA-1462054	5.559433e-01	0.255
Sodium/Proton exchangers	R-HSA-425986	5.559433e-01	0.255
Activated NTRK2 signals through FYN	R-HSA-9032500	5.559433e-01	0.255
Regulation of TNFR1 signaling	R-HSA-5357905	5.636933e-01	0.249
Effects of PIP2 hydrolysis	R-HSA-114508	5.660127e-01	0.247
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	5.660127e-01	0.247
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	5.715962e-01	0.243
Lagging Strand Synthesis	R-HSA-69186	5.715962e-01	0.243
Early Phase of HIV Life Cycle	R-HSA-162594	5.715962e-01	0.243
Signalling to RAS	R-HSA-167044	5.715962e-01	0.243
Glycolysis	R-HSA-70171	5.736595e-01	0.241
Protein ubiquitination	R-HSA-8852135	5.743776e-01	0.241
Integration of energy metabolism	R-HSA-163685	5.746730e-01	0.241
Formation of paraxial mesoderm	R-HSA-9793380	5.756401e-01	0.240
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	5.826285e-01	0.235
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	5.826285e-01	0.235
Mitophagy	R-HSA-5205647	5.826285e-01	0.235
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	5.826285e-01	0.235
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	5.832620e-01	0.234
Extra-nuclear estrogen signaling	R-HSA-9009391	5.836768e-01	0.234
ALK mutants bind TKIs	R-HSA-9700645	5.875461e-01	0.231
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	5.875461e-01	0.231
Activation of the AP-1 family of transcription factors	R-HSA-450341	5.875461e-01	0.231
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	5.875461e-01	0.231
p75NTR regulates axonogenesis	R-HSA-193697	5.875461e-01	0.231
mRNA Editing	R-HSA-75072	5.875461e-01	0.231
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	5.875461e-01	0.231
ARMS-mediated activation	R-HSA-170984	5.875461e-01	0.231
Regulation of signaling by NODAL	R-HSA-1433617	5.875461e-01	0.231
Regulation of NPAS4 gene transcription	R-HSA-9768777	5.875461e-01	0.231
Regulation of CDH11 gene transcription	R-HSA-9762293	5.875461e-01	0.231
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	5.875461e-01	0.231
Interleukin-1 processing	R-HSA-448706	5.875461e-01	0.231
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	5.875461e-01	0.231
Cellular response to mitochondrial stress	R-HSA-9840373	5.875461e-01	0.231
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	5.920308e-01	0.228
G2/M Checkpoints	R-HSA-69481	6.008172e-01	0.221
TP53 Regulates Metabolic Genes	R-HSA-5628897	6.018671e-01	0.220
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	6.059501e-01	0.218
Degradation of CDH1	R-HSA-9766229	6.059501e-01	0.218
FGFR2 alternative splicing	R-HSA-6803529	6.117285e-01	0.213
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	6.117285e-01	0.213
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	6.117285e-01	0.213
Notch-HLH transcription pathway	R-HSA-350054	6.117285e-01	0.213
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	6.117285e-01	0.213
Signaling by KIT in disease	R-HSA-9669938	6.117285e-01	0.213
LDL clearance	R-HSA-8964038	6.117285e-01	0.213
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	6.117285e-01	0.213
Insulin receptor signalling cascade	R-HSA-74751	6.128974e-01	0.213
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	6.146217e-01	0.211
RNA Polymerase III Transcription	R-HSA-74158	6.146217e-01	0.211
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	6.146217e-01	0.211
RUNX2 regulates bone development	R-HSA-8941326	6.146217e-01	0.211
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	6.169016e-01	0.210
Folding of actin by CCT/TriC	R-HSA-390450	6.169016e-01	0.210
Regulation of CDH11 function	R-HSA-9762292	6.169016e-01	0.210
Binding and entry of HIV virion	R-HSA-173107	6.169016e-01	0.210
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	6.169016e-01	0.210
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	6.169016e-01	0.210
EGFR Transactivation by Gastrin	R-HSA-2179392	6.169016e-01	0.210
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	6.169016e-01	0.210
2-LTR circle formation	R-HSA-164843	6.169016e-01	0.210
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	6.169016e-01	0.210
Pexophagy	R-HSA-9664873	6.169016e-01	0.210
PI3K Cascade	R-HSA-109704	6.194676e-01	0.208
TRAF6 mediated IRF7 activation	R-HSA-933541	6.299844e-01	0.201
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	6.306908e-01	0.200
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	6.306908e-01	0.200
Free fatty acids regulate insulin secretion	R-HSA-400451	6.306908e-01	0.200
Growth hormone receptor signaling	R-HSA-982772	6.306908e-01	0.200
Meiotic recombination	R-HSA-912446	6.326902e-01	0.199
Processing of DNA double-strand break ends	R-HSA-5693607	6.410988e-01	0.193
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	6.441693e-01	0.191
Signaling by APC mutants	R-HSA-4839744	6.441693e-01	0.191
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	6.441693e-01	0.191
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	6.441693e-01	0.191
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	6.441693e-01	0.191
Activated NTRK3 signals through RAS	R-HSA-9034864	6.441693e-01	0.191
Bicarbonate transporters	R-HSA-425381	6.441693e-01	0.191
Regulation of localization of FOXO transcription factors	R-HSA-9614399	6.441693e-01	0.191
PECAM1 interactions	R-HSA-210990	6.441693e-01	0.191
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	6.441693e-01	0.191
RNA Polymerase I Promoter Escape	R-HSA-73772	6.456128e-01	0.190
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	6.456128e-01	0.190
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	6.456128e-01	0.190
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	6.489224e-01	0.188
Regulation of T cell activation by CD28 family	R-HSA-388841	6.502068e-01	0.187
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	6.554208e-01	0.183
Interferon Signaling	R-HSA-913531	6.566252e-01	0.183
Formation of a pool of free 40S subunits	R-HSA-72689	6.649374e-01	0.177
Tight junction interactions	R-HSA-420029	6.664314e-01	0.176
Long-term potentiation	R-HSA-9620244	6.664314e-01	0.176
Polymerase switching on the C-strand of the telomere	R-HSA-174411	6.664314e-01	0.176
MicroRNA (miRNA) biogenesis	R-HSA-203927	6.664314e-01	0.176
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	6.664314e-01	0.176
Signaling by GSK3beta mutants	R-HSA-5339716	6.694978e-01	0.174
Integration of provirus	R-HSA-162592	6.694978e-01	0.174
Activated NTRK2 signals through RAS	R-HSA-9026519	6.694978e-01	0.174
Signaling by AXIN mutants	R-HSA-4839735	6.694978e-01	0.174
Signaling by AMER1 mutants	R-HSA-4839748	6.694978e-01	0.174
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	6.694978e-01	0.174
Regulation of RUNX3 expression and activity	R-HSA-8941858	6.734885e-01	0.172
Interleukin-2 family signaling	R-HSA-451927	6.734885e-01	0.172
Nuclear signaling by ERBB4	R-HSA-1251985	6.734885e-01	0.172
Generation of second messenger molecules	R-HSA-202433	6.734885e-01	0.172
COPI-mediated anterograde transport	R-HSA-6807878	6.742916e-01	0.171
Degradation of beta-catenin by the destruction complex	R-HSA-195253	6.813508e-01	0.167
Cyclin E associated events during G1/S transition	R-HSA-69202	6.813508e-01	0.167
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	6.813508e-01	0.167
G alpha (z) signalling events	R-HSA-418597	6.825462e-01	0.166
Metalloprotease DUBs	R-HSA-5689901	6.832282e-01	0.165
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	6.832282e-01	0.165
Signaling by TGF-beta Receptor Complex	R-HSA-170834	6.834811e-01	0.165
Gastrulation	R-HSA-9758941	6.866439e-01	0.163
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	6.871245e-01	0.163
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	6.919303e-01	0.160
MyD88 cascade initiated on plasma membrane	R-HSA-975871	6.925042e-01	0.160
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	6.925042e-01	0.160
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	6.925042e-01	0.160
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	6.930247e-01	0.159
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	6.930247e-01	0.159
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	6.930247e-01	0.159
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	6.930247e-01	0.159
GRB2 events in EGFR signaling	R-HSA-179812	6.930247e-01	0.159
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	6.930247e-01	0.159
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	6.930247e-01	0.159
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	6.930247e-01	0.159
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	6.930247e-01	0.159
RUNX3 regulates p14-ARF	R-HSA-8951936	6.930247e-01	0.159
Regulation of IFNG signaling	R-HSA-877312	6.930247e-01	0.159
VLDLR internalisation and degradation	R-HSA-8866427	6.930247e-01	0.159
Serotonin clearance from the synaptic cleft	R-HSA-380615	6.930247e-01	0.159
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	6.930247e-01	0.159
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	6.930247e-01	0.159
Nonsense-Mediated Decay (NMD)	R-HSA-927802	6.941017e-01	0.159
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	6.941017e-01	0.159
TNF signaling	R-HSA-75893	6.942386e-01	0.158
RNA Polymerase I Transcription Termination	R-HSA-73863	6.993255e-01	0.155
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	6.993255e-01	0.155
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	6.993255e-01	0.155
Signaling by NTRK2 (TRKB)	R-HSA-9006115	6.993255e-01	0.155
Influenza Infection	R-HSA-168255	7.000416e-01	0.155
Degradation of GLI1 by the proteasome	R-HSA-5610780	7.003292e-01	0.155
SLC-mediated transport of neurotransmitters	R-HSA-442660	7.003292e-01	0.155
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	7.003292e-01	0.155
XBP1(S) activates chaperone genes	R-HSA-381038	7.011500e-01	0.154
Interleukin-1 family signaling	R-HSA-446652	7.081828e-01	0.150
Hedgehog 'off' state	R-HSA-5610787	7.100452e-01	0.149
Cleavage of the damaged pyrimidine	R-HSA-110329	7.131054e-01	0.147
Depyrimidination	R-HSA-73928	7.131054e-01	0.147
Negative regulation of FGFR3 signaling	R-HSA-5654732	7.147377e-01	0.146
Activation of kainate receptors upon glutamate binding	R-HSA-451326	7.147377e-01	0.146
Inflammasomes	R-HSA-622312	7.147377e-01	0.146
PDH complex synthesizes acetyl-CoA from PYR	R-HSA-9861559	7.148782e-01	0.146
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	7.148782e-01	0.146
PI5P Regulates TP53 Acetylation	R-HSA-6811555	7.148782e-01	0.146
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	7.148782e-01	0.146
CD28 dependent Vav1 pathway	R-HSA-389359	7.148782e-01	0.146
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	7.148782e-01	0.146
G2/M DNA damage checkpoint	R-HSA-69473	7.222106e-01	0.141
Signaling by ERBB4	R-HSA-1236394	7.222106e-01	0.141
Signaling by FGFR4	R-HSA-5654743	7.254567e-01	0.139
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	7.264292e-01	0.139
Oxidative Stress Induced Senescence	R-HSA-2559580	7.269055e-01	0.139
Late endosomal microautophagy	R-HSA-9615710	7.294807e-01	0.137
Regulation of CDH11 Expression and Function	R-HSA-9759475	7.294807e-01	0.137
Platelet calcium homeostasis	R-HSA-418360	7.294807e-01	0.137
Negative regulation of FGFR4 signaling	R-HSA-5654733	7.294807e-01	0.137
Glucagon-type ligand receptors	R-HSA-420092	7.294807e-01	0.137
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	7.351771e-01	0.134
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	7.351771e-01	0.134
CRMPs in Sema3A signaling	R-HSA-399956	7.351771e-01	0.134
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	7.351771e-01	0.134
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	7.351771e-01	0.134
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	7.351771e-01	0.134
Signaling by FGFR4 in disease	R-HSA-5655291	7.351771e-01	0.134
Signal regulatory protein family interactions	R-HSA-391160	7.351771e-01	0.134
Base Excision Repair	R-HSA-73884	7.372201e-01	0.132
Signaling by NOTCH1 in Cancer	R-HSA-2644603	7.379061e-01	0.132
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	7.379061e-01	0.132
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	7.379061e-01	0.132
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	7.379061e-01	0.132
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	7.379061e-01	0.132
Negative regulation of the PI3K/AKT network	R-HSA-199418	7.412068e-01	0.130
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	7.419594e-01	0.130
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	7.430803e-01	0.129
RNA Polymerase III Transcription Initiation	R-HSA-76046	7.435718e-01	0.129
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	7.435718e-01	0.129
PLC beta mediated events	R-HSA-112043	7.480533e-01	0.126
Regulation of RUNX2 expression and activity	R-HSA-8939902	7.480533e-01	0.126
Somitogenesis	R-HSA-9824272	7.489048e-01	0.126
DAG and IP3 signaling	R-HSA-1489509	7.489048e-01	0.126
Signaling by FGFR3	R-HSA-5654741	7.489048e-01	0.126
Glucose metabolism	R-HSA-70326	7.491112e-01	0.125
RSV-host interactions	R-HSA-9833110	7.509101e-01	0.124
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	7.540320e-01	0.123
Beta-catenin phosphorylation cascade	R-HSA-196299	7.540320e-01	0.123
ERBB2 Regulates Cell Motility	R-HSA-6785631	7.540320e-01	0.123
Telomere C-strand synthesis initiation	R-HSA-174430	7.540320e-01	0.123
Sema3A PAK dependent Axon repulsion	R-HSA-399954	7.540320e-01	0.123
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	7.540320e-01	0.123
SHC1 events in EGFR signaling	R-HSA-180336	7.540320e-01	0.123
Signaling by Activin	R-HSA-1502540	7.540320e-01	0.123
p38MAPK events	R-HSA-171007	7.540320e-01	0.123
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	7.540320e-01	0.123
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	7.540320e-01	0.123
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	7.540320e-01	0.123
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	7.540320e-01	0.123
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	7.540320e-01	0.123
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	7.540320e-01	0.123
Protein methylation	R-HSA-8876725	7.540320e-01	0.123
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	7.540488e-01	0.123
IRE1alpha activates chaperones	R-HSA-381070	7.540488e-01	0.123
Budding and maturation of HIV virion	R-HSA-162588	7.570289e-01	0.121
Cargo concentration in the ER	R-HSA-5694530	7.570289e-01	0.121
Signaling by PDGF	R-HSA-186797	7.578970e-01	0.120
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	7.600134e-01	0.119
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	7.600134e-01	0.119
Diseases of DNA repair	R-HSA-9675135	7.600134e-01	0.119
Developmental Cell Lineages	R-HSA-9734767	7.674095e-01	0.115
rRNA modification in the nucleus and cytosol	R-HSA-6790901	7.674403e-01	0.115
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	7.698708e-01	0.114
Signaling by WNT in cancer	R-HSA-4791275	7.698708e-01	0.114
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	7.707206e-01	0.113
Class I peroxisomal membrane protein import	R-HSA-9603798	7.715456e-01	0.113
Negative regulation of FLT3	R-HSA-9706369	7.715456e-01	0.113
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	7.715456e-01	0.113
ER to Golgi Anterograde Transport	R-HSA-199977	7.737513e-01	0.111
Signaling by FGFR2	R-HSA-5654738	7.762210e-01	0.110
PKR-mediated signaling	R-HSA-9833482	7.762210e-01	0.110
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	7.766869e-01	0.110
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	7.805195e-01	0.108
GPER1 signaling	R-HSA-9634597	7.810340e-01	0.107
Co-stimulation by CD28	R-HSA-389356	7.810340e-01	0.107
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	7.821170e-01	0.107
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	7.821170e-01	0.107
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	7.821170e-01	0.107
Cardiogenesis	R-HSA-9733709	7.821170e-01	0.107
Negative regulation of FGFR1 signaling	R-HSA-5654726	7.821170e-01	0.107
Regulation of necroptotic cell death	R-HSA-5675482	7.821170e-01	0.107
MyD88 dependent cascade initiated on endosome	R-HSA-975155	7.874979e-01	0.104
SHC1 events in ERBB4 signaling	R-HSA-1250347	7.878131e-01	0.104
Transcriptional regulation of testis differentiation	R-HSA-9690406	7.878131e-01	0.104
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	7.878131e-01	0.104
Coenzyme A biosynthesis	R-HSA-196783	7.878131e-01	0.104
tRNA modification in the mitochondrion	R-HSA-6787450	7.878131e-01	0.104
Resolution of D-Loop Structures	R-HSA-5693537	7.937872e-01	0.100
Glucagon signaling in metabolic regulation	R-HSA-163359	7.937872e-01	0.100
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	7.937872e-01	0.100
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	7.937872e-01	0.100
Regulation of RAS by GAPs	R-HSA-5658442	8.005117e-01	0.097
Signaling by FGFR2 in disease	R-HSA-5655253	8.005117e-01	0.097
HDR through Homologous Recombination (HRR)	R-HSA-5685942	8.026867e-01	0.095
G-protein mediated events	R-HSA-112040	8.026867e-01	0.095
PI3K events in ERBB2 signaling	R-HSA-1963642	8.029231e-01	0.095
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	8.029231e-01	0.095
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	8.029231e-01	0.095
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	8.029231e-01	0.095
Glycogen storage diseases	R-HSA-3229121	8.029231e-01	0.095
Constitutive Signaling by EGFRvIII	R-HSA-5637810	8.029231e-01	0.095
Signaling by EGFRvIII in Cancer	R-HSA-5637812	8.029231e-01	0.095
Regulation of NPAS4 gene expression	R-HSA-9768759	8.029231e-01	0.095
Regulation of FZD by ubiquitination	R-HSA-4641263	8.029231e-01	0.095
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	8.029231e-01	0.095
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	8.029231e-01	0.095
Uptake and function of anthrax toxins	R-HSA-5210891	8.029231e-01	0.095
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	8.049012e-01	0.094
NOD1/2 Signaling Pathway	R-HSA-168638	8.049012e-01	0.094
Negative regulation of FGFR2 signaling	R-HSA-5654727	8.049012e-01	0.094
Signaling by NOTCH2	R-HSA-1980145	8.049012e-01	0.094
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	8.085612e-01	0.092
MAPK family signaling cascades	R-HSA-5683057	8.116008e-01	0.091
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	8.137492e-01	0.090
MAPK6/MAPK4 signaling	R-HSA-5687128	8.147551e-01	0.089
Regulation of Apoptosis	R-HSA-169911	8.154790e-01	0.089
PERK regulates gene expression	R-HSA-381042	8.154790e-01	0.089
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	8.154790e-01	0.089
RAF/MAP kinase cascade	R-HSA-5673001	8.169359e-01	0.088
Transport of connexons to the plasma membrane	R-HSA-190872	8.169580e-01	0.088
RNA Polymerase III Transcription Termination	R-HSA-73980	8.169580e-01	0.088
Regulation of TP53 Activity through Methylation	R-HSA-6804760	8.169580e-01	0.088
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	8.169580e-01	0.088
Tie2 Signaling	R-HSA-210993	8.169580e-01	0.088
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	8.169580e-01	0.088
Parasite infection	R-HSA-9664407	8.169990e-01	0.088
Leishmania phagocytosis	R-HSA-9664417	8.169990e-01	0.088
FCGR3A-mediated phagocytosis	R-HSA-9664422	8.169990e-01	0.088
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	8.185151e-01	0.087
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	8.186167e-01	0.087
SARS-CoV-2 Infection	R-HSA-9694516	8.190328e-01	0.087
PPARA activates gene expression	R-HSA-1989781	8.194034e-01	0.087
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	8.224690e-01	0.085
HSF1 activation	R-HSA-3371511	8.255406e-01	0.083
Calmodulin induced events	R-HSA-111933	8.255406e-01	0.083
CaM pathway	R-HSA-111997	8.255406e-01	0.083
Glycosphingolipid transport	R-HSA-9845576	8.255406e-01	0.083
Regulation of TP53 Degradation	R-HSA-6804757	8.255406e-01	0.083
FGFR2 mutant receptor activation	R-HSA-1839126	8.255406e-01	0.083
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	8.269866e-01	0.083
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	8.269866e-01	0.083
Golgi Associated Vesicle Biogenesis	R-HSA-432722	8.269866e-01	0.083
Pre-NOTCH Processing in Golgi	R-HSA-1912420	8.299942e-01	0.081
Impaired BRCA2 binding to PALB2	R-HSA-9709603	8.299942e-01	0.081
Germ layer formation at gastrulation	R-HSA-9754189	8.299942e-01	0.081
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	8.299942e-01	0.081
Regulation of signaling by CBL	R-HSA-912631	8.299942e-01	0.081
Specification of the neural plate border	R-HSA-9834899	8.299942e-01	0.081
The NLRP3 inflammasome	R-HSA-844456	8.299942e-01	0.081
Hedgehog 'on' state	R-HSA-5632684	8.334725e-01	0.079
Cargo trafficking to the periciliary membrane	R-HSA-5620920	8.334725e-01	0.079
Cellular response to starvation	R-HSA-9711097	8.346074e-01	0.079
Collagen chain trimerization	R-HSA-8948216	8.351059e-01	0.078
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	8.351171e-01	0.078
Base-Excision Repair, AP Site Formation	R-HSA-73929	8.351171e-01	0.078
Chaperonin-mediated protein folding	R-HSA-390466	8.352048e-01	0.078
trans-Golgi Network Vesicle Budding	R-HSA-199992	8.405114e-01	0.075
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	8.405114e-01	0.075
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	8.411763e-01	0.075
HCMV Infection	R-HSA-9609646	8.414629e-01	0.075
Peptide chain elongation	R-HSA-156902	8.415974e-01	0.075
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	8.421026e-01	0.075
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	8.421026e-01	0.075
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	8.421026e-01	0.075
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	8.421026e-01	0.075
Glycogen synthesis	R-HSA-3322077	8.421026e-01	0.075
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	8.421026e-01	0.075
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	8.421026e-01	0.075
Signal transduction by L1	R-HSA-445144	8.421026e-01	0.075
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	8.429163e-01	0.074
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	8.429163e-01	0.074
MAPK1/MAPK3 signaling	R-HSA-5684996	8.435014e-01	0.074
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	8.441945e-01	0.074
RIPK1-mediated regulated necrosis	R-HSA-5213460	8.441945e-01	0.074
SARS-CoV-1 Infection	R-HSA-9678108	8.456880e-01	0.073
Ca2+ pathway	R-HSA-4086398	8.472988e-01	0.072
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	8.503937e-01	0.070
Signaling by FGFR1	R-HSA-5654736	8.503937e-01	0.070
Cellular response to chemical stress	R-HSA-9711123	8.518303e-01	0.070
Plasma lipoprotein clearance	R-HSA-8964043	8.528258e-01	0.069
Regulation of TP53 Expression and Degradation	R-HSA-6806003	8.528258e-01	0.069
SHC-mediated cascade:FGFR3	R-HSA-5654704	8.533494e-01	0.069
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	8.533494e-01	0.069
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	8.533494e-01	0.069
TNFR1-induced proapoptotic signaling	R-HSA-5357786	8.533494e-01	0.069
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	8.533494e-01	0.069
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	8.533494e-01	0.069
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	8.533494e-01	0.069
Basigin interactions	R-HSA-210991	8.533494e-01	0.069
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	8.586291e-01	0.066
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	8.586291e-01	0.066
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	8.595586e-01	0.066
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	8.601428e-01	0.065
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	8.609857e-01	0.065
Glycogen metabolism	R-HSA-8982491	8.610187e-01	0.065
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	8.637956e-01	0.064
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	8.637956e-01	0.064
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	8.637956e-01	0.064
SHC-mediated cascade:FGFR4	R-HSA-5654719	8.637956e-01	0.064
FRS-mediated FGFR3 signaling	R-HSA-5654706	8.637956e-01	0.064
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	8.637956e-01	0.064
Molybdenum cofactor biosynthesis	R-HSA-947581	8.637956e-01	0.064
Signaling by Insulin receptor	R-HSA-74752	8.705606e-01	0.060
Eukaryotic Translation Elongation	R-HSA-156842	8.705606e-01	0.060
Protein folding	R-HSA-391251	8.705606e-01	0.060
Extension of Telomeres	R-HSA-180786	8.709923e-01	0.060
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	8.711665e-01	0.060
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	8.720527e-01	0.059
Muscle contraction	R-HSA-397014	8.725104e-01	0.059
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	8.730135e-01	0.059
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	8.730135e-01	0.059
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	8.734984e-01	0.059
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	8.734984e-01	0.059
FRS-mediated FGFR4 signaling	R-HSA-5654712	8.734984e-01	0.059
Ethanol oxidation	R-HSA-71384	8.734984e-01	0.059
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	8.734984e-01	0.059
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	8.734984e-01	0.059
Beta-catenin independent WNT signaling	R-HSA-3858494	8.756136e-01	0.058
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	8.761637e-01	0.057
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	8.761637e-01	0.057
Degradation of CRY and PER proteins	R-HSA-9932298	8.761637e-01	0.057
Intra-Golgi traffic	R-HSA-6811438	8.761637e-01	0.057
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	8.775311e-01	0.057
MHC class II antigen presentation	R-HSA-2132295	8.775311e-01	0.057
PCP/CE pathway	R-HSA-4086400	8.776726e-01	0.057
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	8.798294e-01	0.056
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	8.808246e-01	0.055
Collagen formation	R-HSA-1474290	8.808246e-01	0.055
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	8.825105e-01	0.054
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	8.825105e-01	0.054
Organic anion transport by SLCO transporters	R-HSA-879518	8.825105e-01	0.054
Syndecan interactions	R-HSA-3000170	8.825105e-01	0.054
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	8.831516e-01	0.054
Ca-dependent events	R-HSA-111996	8.831516e-01	0.054
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	8.852652e-01	0.053
MyD88-independent TLR4 cascade	R-HSA-166166	8.852652e-01	0.053
TCR signaling	R-HSA-202403	8.852652e-01	0.053
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	8.856909e-01	0.053
Unfolded Protein Response (UPR)	R-HSA-381119	8.879076e-01	0.052
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	8.890426e-01	0.051
NCAM signaling for neurite out-growth	R-HSA-375165	8.890426e-01	0.051
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	8.890426e-01	0.051
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	8.897730e-01	0.051
Eukaryotic Translation Termination	R-HSA-72764	8.903858e-01	0.050
SHC-mediated cascade:FGFR1	R-HSA-5654688	8.908810e-01	0.050
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	8.908810e-01	0.050
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	8.908810e-01	0.050
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	8.908810e-01	0.050
Complex III assembly	R-HSA-9865881	8.908810e-01	0.050
Amyloid fiber formation	R-HSA-977225	8.932660e-01	0.049
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	8.959799e-01	0.048
Proteasome assembly	R-HSA-9907900	8.960447e-01	0.048
Amine ligand-binding receptors	R-HSA-375280	8.960447e-01	0.048
HCMV Late Events	R-HSA-9610379	8.973506e-01	0.047
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	8.986557e-01	0.046
FRS-mediated FGFR1 signaling	R-HSA-5654693	8.986557e-01	0.046
Defects in cobalamin (B12) metabolism	R-HSA-3296469	8.986557e-01	0.046
Hyaluronan degradation	R-HSA-2160916	8.986557e-01	0.046
VEGFR2 mediated cell proliferation	R-HSA-5218921	8.986557e-01	0.046
Laminin interactions	R-HSA-3000157	8.986557e-01	0.046
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	8.986557e-01	0.046
Glycogen breakdown (glycogenolysis)	R-HSA-70221	8.986557e-01	0.046
Nucleosome assembly	R-HSA-774815	9.019827e-01	0.045
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	9.019827e-01	0.045
Fanconi Anemia Pathway	R-HSA-6783310	9.019827e-01	0.045
Asymmetric localization of PCP proteins	R-HSA-4608870	9.019827e-01	0.045
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.019827e-01	0.045
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.019827e-01	0.045
Cellular responses to mechanical stimuli	R-HSA-9855142	9.020138e-01	0.045
Cytoprotection by HMOX1	R-HSA-9707564	9.026671e-01	0.044
Regulation of insulin secretion	R-HSA-422356	9.034860e-01	0.044
Signaling by FGFR	R-HSA-190236	9.034860e-01	0.044
Interferon gamma signaling	R-HSA-877300	9.041192e-01	0.044
Cellular response to hypoxia	R-HSA-1234174	9.047985e-01	0.043
MET activates PTK2 signaling	R-HSA-8874081	9.058768e-01	0.043
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	9.058768e-01	0.043
Signaling by EGFR in Cancer	R-HSA-1643713	9.058768e-01	0.043
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	9.058768e-01	0.043
TRP channels	R-HSA-3295583	9.058768e-01	0.043
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.058768e-01	0.043
Cellular responses to stress	R-HSA-2262752	9.084128e-01	0.042
Processive synthesis on the C-strand of the telomere	R-HSA-174414	9.125839e-01	0.040
Packaging Of Telomere Ends	R-HSA-171306	9.125839e-01	0.040
EPHA-mediated growth cone collapse	R-HSA-3928663	9.125839e-01	0.040
CD28 dependent PI3K/Akt signaling	R-HSA-389357	9.125839e-01	0.040
Cobalamin (Cbl) metabolism	R-HSA-9759218	9.125839e-01	0.040
SHC-mediated cascade:FGFR2	R-HSA-5654699	9.125839e-01	0.040
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	9.125839e-01	0.040
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	9.125839e-01	0.040
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	9.125839e-01	0.040
Triglyceride biosynthesis	R-HSA-75109	9.125839e-01	0.040
Signaling by FGFR3 in disease	R-HSA-5655332	9.125839e-01	0.040
Insulin processing	R-HSA-264876	9.125839e-01	0.040
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	9.129202e-01	0.040
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	9.129202e-01	0.040
Selenocysteine synthesis	R-HSA-2408557	9.152010e-01	0.038
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.153966e-01	0.038
Telomere Extension By Telomerase	R-HSA-171319	9.188133e-01	0.037
FRS-mediated FGFR2 signaling	R-HSA-5654700	9.188133e-01	0.037
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	9.188133e-01	0.037
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.188133e-01	0.037
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	9.217960e-01	0.035
Viral mRNA Translation	R-HSA-192823	9.222985e-01	0.035
Chemokine receptors bind chemokines	R-HSA-380108	9.227045e-01	0.035
Impaired BRCA2 binding to RAD51	R-HSA-9709570	9.245992e-01	0.034
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.245992e-01	0.034
Downstream signaling of activated FGFR3	R-HSA-5654708	9.245992e-01	0.034
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.245992e-01	0.034
Signaling by CSF3 (G-CSF)	R-HSA-9674555	9.245992e-01	0.034
Response of endothelial cells to shear stress	R-HSA-9860931	9.256459e-01	0.034
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	9.266122e-01	0.033
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.266122e-01	0.033
Phospholipid metabolism	R-HSA-1483257	9.268431e-01	0.033
DAP12 signaling	R-HSA-2424491	9.299731e-01	0.032
Downstream signaling of activated FGFR4	R-HSA-5654716	9.299731e-01	0.032
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.299731e-01	0.032
Neurotransmitter clearance	R-HSA-112311	9.299731e-01	0.032
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	9.303831e-01	0.031
Regulation of mitotic cell cycle	R-HSA-453276	9.303831e-01	0.031
Activation of NF-kappaB in B cells	R-HSA-1169091	9.314458e-01	0.031
Cytosolic sulfonation of small molecules	R-HSA-156584	9.314458e-01	0.031
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	9.326470e-01	0.030
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.339750e-01	0.030
Viral Infection Pathways	R-HSA-9824446	9.343821e-01	0.029
Platelet homeostasis	R-HSA-418346	9.349321e-01	0.029
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	9.349643e-01	0.029
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	9.349643e-01	0.029
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.349643e-01	0.029
Transcriptional Regulation by NPAS4	R-HSA-9634815	9.354574e-01	0.029
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.372922e-01	0.028
Signaling by Hedgehog	R-HSA-5358351	9.384648e-01	0.028
Regulation of PTEN stability and activity	R-HSA-8948751	9.392458e-01	0.027
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.396000e-01	0.027
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	9.396000e-01	0.027
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.396493e-01	0.027
Cytokine Signaling in Immune system	R-HSA-1280215	9.400990e-01	0.027
Formation of the cornified envelope	R-HSA-6809371	9.402249e-01	0.027
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	9.439055e-01	0.025
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	9.439055e-01	0.025
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	9.476467e-01	0.023
Acyl chain remodelling of PC	R-HSA-1482788	9.479044e-01	0.023
Vpu mediated degradation of CD4	R-HSA-180534	9.479044e-01	0.023
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	9.479044e-01	0.023
Transmission across Chemical Synapses	R-HSA-112315	9.479455e-01	0.023
Ion homeostasis	R-HSA-5578775	9.493834e-01	0.023
eNOS activation	R-HSA-203615	9.516184e-01	0.022
Gap junction assembly	R-HSA-190861	9.516184e-01	0.022
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	9.516184e-01	0.022
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	9.516184e-01	0.022
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.516184e-01	0.022
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	9.516184e-01	0.022
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	9.516184e-01	0.022
Hyaluronan metabolism	R-HSA-2142845	9.516184e-01	0.022
Signal amplification	R-HSA-392518	9.516184e-01	0.022
NPAS4 regulates expression of target genes	R-HSA-9768919	9.516184e-01	0.022
Cholesterol biosynthesis	R-HSA-191273	9.521662e-01	0.021
Signaling by Interleukins	R-HSA-449147	9.549326e-01	0.020
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	9.550678e-01	0.020
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	9.550678e-01	0.020
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	9.550678e-01	0.020
Acyl chain remodelling of PE	R-HSA-1482839	9.550678e-01	0.020
Downstream signaling of activated FGFR2	R-HSA-5654696	9.550678e-01	0.020
Downstream signaling of activated FGFR1	R-HSA-5654687	9.550678e-01	0.020
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.550678e-01	0.020
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.552221e-01	0.020
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	9.571076e-01	0.019
Peroxisomal protein import	R-HSA-9033241	9.578942e-01	0.019
Lysosome Vesicle Biogenesis	R-HSA-432720	9.582715e-01	0.019
Vif-mediated degradation of APOBEC3G	R-HSA-180585	9.582715e-01	0.019
Extracellular matrix organization	R-HSA-1474244	9.587897e-01	0.018
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.604131e-01	0.018
Degradation of DVL	R-HSA-4641258	9.612470e-01	0.017
Degradation of AXIN	R-HSA-4641257	9.612470e-01	0.017
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	9.612470e-01	0.017
Cleavage of the damaged purine	R-HSA-110331	9.612470e-01	0.017
SLC-mediated transport of organic cations	R-HSA-549127	9.612470e-01	0.017
Cellular responses to stimuli	R-HSA-8953897	9.619136e-01	0.017
SLC transporter disorders	R-HSA-5619102	9.624890e-01	0.017
Aquaporin-mediated transport	R-HSA-445717	9.627871e-01	0.016
Collagen degradation	R-HSA-1442490	9.627871e-01	0.016
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.629347e-01	0.016
Transport to the Golgi and subsequent modification	R-HSA-948021	9.637022e-01	0.016
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	9.640104e-01	0.016
Depurination	R-HSA-73927	9.640104e-01	0.016
SLC-mediated transport of inorganic anions	R-HSA-9958790	9.640104e-01	0.016
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	9.640104e-01	0.016
Interleukin-1 signaling	R-HSA-9020702	9.649975e-01	0.015
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.665770e-01	0.015
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.665770e-01	0.015
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.665770e-01	0.015
Stabilization of p53	R-HSA-69541	9.665770e-01	0.015
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.669143e-01	0.015
tRNA processing	R-HSA-72306	9.681110e-01	0.014
Negative regulation of NOTCH4 signaling	R-HSA-9604323	9.689606e-01	0.014
Diseases associated with the TLR signaling cascade	R-HSA-5602358	9.689606e-01	0.014
Diseases of Immune System	R-HSA-5260271	9.689606e-01	0.014
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.689606e-01	0.014
Platelet activation, signaling and aggregation	R-HSA-76002	9.691638e-01	0.014
Opioid Signalling	R-HSA-111885	9.699702e-01	0.013
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	9.709852e-01	0.013
Hh mutants are degraded by ERAD	R-HSA-5362768	9.711744e-01	0.013
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	9.711744e-01	0.013
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.711744e-01	0.013
Maturation of spike protein	R-HSA-9694548	9.711744e-01	0.013
Ribosome-associated quality control	R-HSA-9948299	9.716966e-01	0.012
Ub-specific processing proteases	R-HSA-5689880	9.718134e-01	0.012
Toll-like Receptor Cascades	R-HSA-168898	9.718513e-01	0.012
Degradation of GLI2 by the proteasome	R-HSA-5610783	9.732304e-01	0.012
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	9.732304e-01	0.012
Kidney development	R-HSA-9830369	9.744013e-01	0.011
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.751399e-01	0.011
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.759603e-01	0.011
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	9.759603e-01	0.011
Regulated Necrosis	R-HSA-5218859	9.759603e-01	0.011
Neurotransmitter release cycle	R-HSA-112310	9.767525e-01	0.010
Downstream TCR signaling	R-HSA-202424	9.767525e-01	0.010
Stimuli-sensing channels	R-HSA-2672351	9.768180e-01	0.010
Defensins	R-HSA-1461973	9.769133e-01	0.010
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.769133e-01	0.010
DAP12 interactions	R-HSA-2172127	9.785603e-01	0.009
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.785603e-01	0.009
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	9.785603e-01	0.009
Surfactant metabolism	R-HSA-5683826	9.785603e-01	0.009
COPII-mediated vesicle transport	R-HSA-204005	9.788073e-01	0.009
Platelet degranulation	R-HSA-114608	9.789731e-01	0.009
Neuronal System	R-HSA-112316	9.796706e-01	0.009
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.800899e-01	0.009
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.800899e-01	0.009
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	9.800899e-01	0.009
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	9.800899e-01	0.009
Metabolism of cofactors	R-HSA-8978934	9.801054e-01	0.009
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.814846e-01	0.008
Regulation of pyruvate metabolism	R-HSA-9861718	9.815104e-01	0.008
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.815104e-01	0.008
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.815104e-01	0.008
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.815104e-01	0.008
Synthesis of PC	R-HSA-1483191	9.828297e-01	0.008
Neddylation	R-HSA-8951664	9.832880e-01	0.007
ROS and RNS production in phagocytes	R-HSA-1222556	9.835539e-01	0.007
Intraflagellar transport	R-HSA-5620924	9.840549e-01	0.007
Gluconeogenesis	R-HSA-70263	9.840549e-01	0.007
Metal ion SLC transporters	R-HSA-425410	9.840549e-01	0.007
Degradation of the extracellular matrix	R-HSA-1474228	9.843852e-01	0.007
Citric acid cycle (TCA cycle)	R-HSA-71403	9.845685e-01	0.007
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.851928e-01	0.006
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	9.851928e-01	0.006
p53-Dependent G1 DNA Damage Response	R-HSA-69563	9.851928e-01	0.006
CLEC7A (Dectin-1) signaling	R-HSA-5607764	9.852879e-01	0.006
Interleukin-12 signaling	R-HSA-9020591	9.855222e-01	0.006
Interferon alpha/beta signaling	R-HSA-909733	9.855960e-01	0.006
Hemostasis	R-HSA-109582	9.859341e-01	0.006
C-type lectin receptors (CLRs)	R-HSA-5621481	9.863265e-01	0.006
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.868154e-01	0.006
Complex IV assembly	R-HSA-9864848	9.872308e-01	0.006
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.872308e-01	0.006
Hedgehog ligand biogenesis	R-HSA-5358346	9.872308e-01	0.006
The phototransduction cascade	R-HSA-2514856	9.872308e-01	0.006
SLC-mediated transport of organic anions	R-HSA-9955298	9.872606e-01	0.006
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.880518e-01	0.005
Uptake and actions of bacterial toxins	R-HSA-5339562	9.881422e-01	0.005
Amino acids regulate mTORC1	R-HSA-9639288	9.889886e-01	0.005
rRNA processing	R-HSA-72312	9.893331e-01	0.005
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.894629e-01	0.005
Digestion	R-HSA-8935690	9.911825e-01	0.004
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.911825e-01	0.004
Synthesis of PA	R-HSA-1483166	9.918120e-01	0.004
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.923966e-01	0.003
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.928717e-01	0.003
Triglyceride metabolism	R-HSA-8979227	9.929395e-01	0.003
Amino acid transport across the plasma membrane	R-HSA-352230	9.929395e-01	0.003
Interleukin-12 family signaling	R-HSA-447115	9.933202e-01	0.003
Metabolism of polyamines	R-HSA-351202	9.934437e-01	0.003
Signaling by Retinoic Acid	R-HSA-5362517	9.934437e-01	0.003
Parasitic Infection Pathways	R-HSA-9824443	9.935507e-01	0.003
Leishmania infection	R-HSA-9658195	9.935507e-01	0.003
Neutrophil degranulation	R-HSA-6798695	9.938532e-01	0.003
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	9.943467e-01	0.002
Class B/2 (Secretin family receptors)	R-HSA-373080	9.945063e-01	0.002
FCERI mediated MAPK activation	R-HSA-2871796	9.945888e-01	0.002
G1/S DNA Damage Checkpoints	R-HSA-69615	9.947504e-01	0.002
Digestion and absorption	R-HSA-8963743	9.947504e-01	0.002
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.954851e-01	0.002
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.957969e-01	0.002
SLC-mediated transport of amino acids	R-HSA-9958863	9.960972e-01	0.002
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.965283e-01	0.002
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.967496e-01	0.001
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.970224e-01	0.001
Glycerophospholipid biosynthesis	R-HSA-1483206	9.970224e-01	0.001
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.970986e-01	0.001
Post-translational protein phosphorylation	R-HSA-8957275	9.971515e-01	0.001
G alpha (q) signalling events	R-HSA-416476	9.973304e-01	0.001
Selenoamino acid metabolism	R-HSA-2408522	9.973589e-01	0.001
Diseases of carbohydrate metabolism	R-HSA-5663084	9.974985e-01	0.001
ABC-family proteins mediated transport	R-HSA-382556	9.975044e-01	0.001
Disorders of transmembrane transporters	R-HSA-5619115	9.976289e-01	0.001
Translation of Structural Proteins	R-HSA-9694635	9.981406e-01	0.001
ABC transporter disorders	R-HSA-5619084	9.982735e-01	0.001
Antigen processing-Cross presentation	R-HSA-1236975	9.986282e-01	0.001
Protein localization	R-HSA-9609507	9.986356e-01	0.001
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.988085e-01	0.001
Adaptive Immune System	R-HSA-1280218	9.990112e-01	0.000
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.991417e-01	0.000
Pyruvate metabolism	R-HSA-70268	9.991779e-01	0.000
Keratinization	R-HSA-6805567	9.991950e-01	0.000
ER-Phagosome pathway	R-HSA-1236974	9.992913e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.993443e-01	0.000
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.994734e-01	0.000
FCERI mediated NF-kB activation	R-HSA-2871837	9.994786e-01	0.000
FCGR activation	R-HSA-2029481	9.995110e-01	0.000
G alpha (s) signalling events	R-HSA-418555	9.995562e-01	0.000
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.995785e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.995832e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.996367e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.996868e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.997093e-01	0.000
Cardiac conduction	R-HSA-5576891	9.997784e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.997840e-01	0.000
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.998138e-01	0.000
Ion channel transport	R-HSA-983712	9.998507e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.998716e-01	0.000
Translation	R-HSA-72766	9.998770e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.998808e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.998894e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999236e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.999236e-01	0.000
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.999292e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999292e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999448e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999611e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.999644e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.999710e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.999768e-01	0.000
Sensory perception of taste	R-HSA-9717189	9.999814e-01	0.000
Infectious disease	R-HSA-5663205	9.999831e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999891e-01	0.000
Post-translational protein modification	R-HSA-597592	9.999896e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.999898e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.999926e-01	0.000
Disease	R-HSA-1643685	9.999951e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999951e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999960e-01	0.000
Asparagine N-linked glycosylation	R-HSA-446203	9.999972e-01	0.000
Immune System	R-HSA-168256	9.999985e-01	0.000
Signaling by GPCR	R-HSA-372790	9.999986e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999986e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999991e-01	0.000
Innate Immune System	R-HSA-168249	9.999994e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999995e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999995e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.999997e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999998e-01	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	9.999999e-01	0.000
Phase II - Conjugation of compounds	R-HSA-156580	9.999999e-01	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	9.999999e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999999e-01	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000
Biological oxidations	R-HSA-211859	1.000000e+00	0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000