CAMK4

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
O14639 S452 Sugiyama ABLIM1 ABLIM KIAA0059 LIMAB1 PtPsAEGyQDVRDRMIHRstsQGsINsPVySRHsYtPTTSR
O14745 S291 Sugiyama NHERF1 NHERF SLC9A3R1 EALAEAALEsPRPALVRsAssDtsEELNsQDsPPKQDSTAP
O14974 S910 Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O14974 S995 Sugiyama PPP1R12A MBS MYPT1 ADRSLLEMEKRERRALERRIsEMEEELKMLPDLKADNQRLK
O43423 S100 Sugiyama ANP32CP PP32R1 AEKCPNLTHLYLSGNKIKDLstIEPLKQLENLKSLDLFNCE
O43823 S323 Sugiyama AKAP8 AKAP95 RKRKQFQLyEEPDtKLARVDsEGDFsENDDAAGDFRsGDEE
O60220 S96 Sugiyama TIMM8A DDP DDP1 TIM8A FILNRLEQTQKSKPVFSEsLsD___________________
O60292 T175 Sugiyama SIPA1L3 KIAA0545 SPAL3 WPRsPGRAFLPLRHRsssEItLSECDAEDAGEPRGARHtGA
O60343 S485 Sugiyama TBC1D4 AS160 KIAA0603 CERIEGLYPPRAKLVIQRHLssLtDNEQADIFERVQKMKPV
O60716 S252 Sugiyama CTNND1 KIAA0384 sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
O60749 S119 Sugiyama SNX2 TRG9 AVtPVtPttLIAPRIESKsMsAPVIFDRsREEIEEEANGDI
O60814 S39 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
O75369 S2532 Sugiyama FLNB FLN1L FLN3 TABP TAP ASKVTSKGAGLSKAFVGQKssFLVDCSKAGSNMLLIGVHGP
O75665 S899 Sugiyama OFD1 CXorf5 EEKIREQQVKERRQREERRQsNLQEVLERERRELEKLyQER
O94776 T621 Sugiyama MTA2 MTA1L1 PID APNPVVFVATKDTRALRKALtHLEMRRAARRPNLPLKVKPT
O95197 S316 Sugiyama RTN3 ASYIP NSPL2 PLRNKEAGRYPMSALLSRQFsHtNAALEEVSRCVNDMHNFT
O95626 S104 Sugiyama ANP32D PP32R2 AEKCPNLIHLNLSGNKIKDLstIEPLKKLENLESLDLFTCE
O95678 S162 Sugiyama KRT75 K6HF KB18 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
O95835 S464 Sugiyama LATS1 WARTS SPSSGHEIPTWQPNIPVRsNsFNNPLGNRASHSANSQPSAT
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P02538 S176 Sugiyama KRT6A K6A KRT6D IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04259 S176 Sugiyama KRT6B K6B KRTL1 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04632 Y87 Sugiyama CAPNS1 CAPN4 CAPNS sAISEAAAQYNPEPPPPRtHysNIEANEsEEVRQFRRLFAQ
P04792 S78 Sugiyama HSPB1 HSP27 HSP28 LPPAAIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVs
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04792 S83 Sugiyama HSPB1 HSP27 HSP28 IEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNH
P05362 S43 Sugiyama ICAM1 GPGNAQTSVSPSKVILPRGGsVLVTCstsCDQPKLLGIETP
P05787 S104 Sugiyama KRT8 CYK8 IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195 T302 Sugiyama LDHB YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07237 S88 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB GKLKAEGSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNG
P07355 S184 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900 S53 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P08238 S45 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 T85 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB LDsGKELKIDIIPNPQERtLtLVDtGIGMtKADLINNLGtI
P08238 T89 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB KELKIDIIPNPQERtLtLVDtGIGMtKADLINNLGtIAKSG
P08729 S104 Sugiyama KRT7 SCL LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P08758 T10 Sugiyama ANXA5 ANX5 ENX2 PP4 ___________MAQVLRGtVtDFPGFDERADAEtLRKAMKG
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P09972 S45 Sugiyama ALDOC ALDC APGKGILAADEsVGsMAKRLsQIGVENtEENRRLYRQVLFs
P10412 S55 Sugiyama H1-4 H1F4 HIST1H1E AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11532 S3623 Sugiyama DMD EAKVNGttVssPstsLQRsDssQPMLLRVVGSQTSDSMGEE
P12035 S211 Sugiyama KRT3 IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P13647 S181 Sugiyama KRT5 IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14625 S106 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14866 S544 SIGNOR|EPSD|PSP HNRNPL HNRPL P/OKcl.14 LGVKRPSSVKVFSGKsERsssGLLEWEsKSDALETLGFLNH
P15336 S62 Sugiyama ATF2 CREB2 CREBP1 LAVHKHKHEMtLKFGPARNDsVIVADQtPtPtRFLKNCEEV
P15531 S122 Sugiyama NME1 NDPKA NM23 GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P16220 S119 SIGNOR|PSP CREB1 EsVDsVTDsQKRREILsRRPsYRKILNDLssDAPGVPRIEE
P16402 S56 Sugiyama H1-3 H1F3 HIST1H1D AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403 S55 Sugiyama H1-2 H1F2 HIST1H1C AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16949 S16 SIGNOR|EPSD|PSP STMN1 C1orf215 LAP18 OP18 _____MAssDIQVKELEKRAsGQAFELILsPRsKEsVPEFP
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17544 S44 Sugiyama ATF7 ATFA LAVHKHKHEMTLKFGPARtDsVIIADQtPtPtRFLKNCEEV
P18615 S115 Sugiyama NELFE RD RDBP KLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLyEs
P18615 S135 Sugiyama NELFE RD RDBP sADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEG
P18825 S358 Sugiyama ADRA2C ADRA2L2 ADRA2RL2 sPGPGGRLSRASSRsVEFFLsRRRRARSSVCRRKVAQAREK
P19338 S328 Sugiyama NCL NLFVGNLNFNKSAPELKtGIsDVFAKNDLAVVDVRIGMTRK
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P22626 S189 Sugiyama HNRNPA2B1 HNRPA2B1 IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P23588 S597 Sugiyama EIF4B KKPEENPASKFssASKyAALsVDGEDENEGEDyAE______
P24534 S141 Sugiyama EEF1B2 EEF1B EF1B ERLAQYESKKAKKPALVAKssILLDVKPWDDEtDMAKLEEC
P25054 S2129 Sugiyama APC DP2.5 NSIVSSLHQAAAAACLsRQAssDSDSILSLKsGIsLGsPFH
P25205 S447 Sugiyama MCM3 EQGRVTIAKAGIHARLNARCsVLAAANPVyGRyDQyKTPME
P26038 S527 Sugiyama MSN ERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHAE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373 T148 Sugiyama RPL13 BBC1 OK/SW-cl.46 PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373 T151 Sugiyama RPL13 BBC1 OK/SW-cl.46 PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P26641 T287 Sugiyama EEF1G EF1G PRO1608 EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P29401 S105 Sugiyama TKT VWAEAGFLAEAELLNLRKIssDLDGHPVPKQAFtDVATGsL
P29475 S852 SIGNOR|iPTMNet NOS1 EMRHPNSVQEERKSYKVRFNsVSSYSDsQKSSGDGPDLRDN
P30050 S138 Sugiyama RPL12 HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30086 S52 Sugiyama PEBP1 PBP PEBP AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P30086 T51 Sugiyama PEBP1 PBP PEBP GAAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDP
P31327 T45 Sugiyama CPS1 AHQKWKFSRPGIRLLSVKAQtAHIVLEDGtKMKGYSFGHPS
P32119 T142 Sugiyama PRDX2 NKEFB TDPX1 EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P35241 S533 Sugiyama RDX ERVTETQKNERVKKQLQALssELAQARDETKKTQNDVLHAE
P35269 T154 Sugiyama GTF2F1 RAP74 AFEAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHF
P35908 S191 Sugiyama KRT2 KRT2A KRT2E IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37837 S13 Sugiyama TALDO1 TAL TALDO TALDOR ________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P39687 S104 Sugiyama ANP32A C15orf1 LANP MAPM PHAP1 AEKCPNLTHLNLsGNKIKDLstIEPLKKLENLKsLDLFNCE
P40818 S719 Sugiyama USP8 KIAA0055 UBPY KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43243 T150 Sugiyama MATR3 KIAA0723 EDKItPENLPQILLQLKRRRtEEGPtLsyGRDGRsAtREPP
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46060 S454 Sugiyama RANGAP1 KIAA1835 SD VstFLAFPsPEKLLRLGPKssVLIAQQTDTSDPEKVVSAFL
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P48668 S176 Sugiyama KRT6C KRT6E IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49588 S775 Sugiyama AARS1 AARS VTGAEAQKALRKAESLKKCLsVMEAKVKAQTAPNKDVQREI
P50990 S23 Sugiyama CCT8 C21orf112 CCTQ KIAA0002 LHVPKAPGFAQMLKEGAKHFsGLEEAVyRNIQACKELAQTT
P50991 S444 Sugiyama CCT4 CCTD SRB GGGAPEIELALRLTEYSRTLsGMEsyCVRAFADAMEVIPST
P52298 S13 Sugiyama NCBP2 CBP20 PIG55 ________MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQE
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53999 S118 Sugiyama SUB1 PC4 RPO2TC1 PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P55735 S184 Sugiyama SEC13 D3S1231E SEC13A SEC13L1 SEC13R PGsLIDHPSGQKPNYIKRFAsGGCDNLIKLWKEEEDGQWKE
P56524 S246 GPS6|EPSD HDAC4 KIAA0288 NHPVLGMYDAKDDFPLRKTAsEPNLKLRSRLKQKVAERRss
P56524 S467 GPS6|SIGNOR|ELM|iPTMNet|EPSD HDAC4 KIAA0288 DRVSPSIHKLRQHRPLGRtQsAPLPQNAQALQHLVIQQQHQ
P56524 S632 GPS6|SIGNOR|ELM|iPTMNet|EPSD HDAC4 KIAA0288 MEAAGIPVSFGGHRPLsRAQssPAsAtFPVSVQEPPTKPRF
P57053 S39 Sugiyama H2BC12L H2BFS H2BS1 VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P58876 S39 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 T318 Sugiyama ACTB VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61978 S417 Sugiyama HNRNPK HNRPK DLAGsIIGKGGQRIKQIRHEsGAsIKIDEPLEGsEDRIITI
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62269 S96 Sugiyama RPS18 D6S218E QYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLKK
P62273 S9 Sugiyama RPS29 ____________MGHQQLyWsHPRKFGQGSRSCRVCSNRHG
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280 T15 Sugiyama RPS11 ______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62714 S43 Sugiyama PPP2CB LNENQVRTLCEKAKEILTKEsNVQEVRCPVTVCGDVHGQFH
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 T320 Sugiyama ACTA2 ACTSA ACTVS GIG46 VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P62807 S39 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA
P62899 S15 Sugiyama RPL31 ______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62906 S64 Sugiyama RPL10A NEDD6 QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62937 T157 Sugiyama PPIA CYPA NIVEAMERFGsRNGKTSKKItIADCGQLE____________
P62979 S134 Sugiyama RPS27A UBA80 UBCEP1 IsRLRRECPsDECGAGVFMAsHFDRHyCGKCCLtyCFNKPE
P63146 S142 Sugiyama UBE2B RAD6B UBCH1 ANSQAAQLYQENKREYEKRVsAIVEQsWNDS__________
P63220 S65 Sugiyama RPS21 RFNGQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF__
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 T318 Sugiyama ACTG1 ACTG VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 T319 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P67775 S43 Sugiyama PPP2CA LSESQVKSLCEKAKEILTKEsNVQEVRCPVTVCGDVHGQFH
P67809 S209 Sugiyama YBX1 NSEP1 YB1 RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P67809 T108 Sugiyama YBX1 NSEP1 YB1 QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P67809 Y99 Sugiyama YBX1 NSEP1 YB1 DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 T320 Sugiyama ACTC1 ACTC VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 T320 Sugiyama ACTA1 ACTA VMSGGTTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P83731 S38 Sugiyama RPL24 GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P83731 S7 Sugiyama RPL24 ______________MKVELCsFsGyKIYPGHGRRYARTDGK
P83731 S86 Sugiyama RPL24 EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098 S37 Sugiyama RPL19 CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
Q01546 S196 Sugiyama KRT76 KRT2B KRT2P IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q04206 S536 EPSD|PSP RELA NFKB3 APLGAPGLPNGLLsGDEDFSsIADMDFsALLSQISS_____
Q04637 S1238 Sugiyama EIF4G1 EIF4F EIF4G EIF4GI RDAVKREAALPPVsPLKAALsEEELEKKsKAIIEEyLHLND
Q06210 S261 Sugiyama GFPT1 GFAT GFPT GsQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDA
Q06323 S55 Sugiyama PSME1 IFI5111 KKIsELDAFLKEPALNEANLsNLKAPLDIPVPDPVKEKEKE
Q06830 T143 Sugiyama PRDX1 PAGA PAGB TDPX2 EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q09028 S147 Sugiyama RBBP4 RBAP48 VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC
Q09472 S24 GPS6|ELM|EPSD EP300 P300 NVVEPGPPsAKRPKLsSPALsASASDGTDFGSLFDLEHDLP
Q12965 T939 Sugiyama MYO1E MYO1C SIGPGLPKNSRPTRRNttQNtGySsGtQNANyPVRAAPPPP
Q13439 S41 Sugiyama GOLGA4 APAQAssNsstPtRMRsRtssFtEQLDEGtPNRESGDTQSF
Q14568 S53 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14CN4 S138 Sugiyama KRT72 K6IRS2 KB35 KRT6 KRT6IRS2 IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15185 S113 Sugiyama PTGES3 P23 TEBP RAKLNWLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGD
Q15785 S93 Sugiyama TOMM34 URCC3 DCTSALALVPFSIKPLLRRAsAyEALEKYPMAYVDYKTVLQ
Q16513 S583 Sugiyama PKN2 PRK2 PRKCL2 VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs
Q16566 S12 GPS6|EPSD CAMK4 CAMK CAMK-GR CAMKIV _________MLKVTVPSCSAssCSSVTASAAPGTASLVPDY
Q16566 S13 GPS6|EPSD CAMK4 CAMK CAMK-GR CAMKIV ________MLKVTVPSCSAssCSSVTASAAPGTASLVPDYW
Q16566 S336 GPS6|EPSD CAMK4 CAMK CAMK-GR CAMKIV KLQEFNARRKLKAAVKAVVAsSRLGsAsssHGsIQEsHKAs
Q16566 S341 iPTMNet CAMK4 CAMK CAMK-GR CAMKIV NARRKLKAAVKAVVAsSRLGsAsssHGsIQEsHKAsRDPsP
Q16566 S356 Sugiyama CAMK4 CAMK CAMK-GR CAMKIV sSRLGsAsssHGsIQEsHKAsRDPsPIQDGNEDMKAIPEGE
Q16566 S360 iPTMNet|Sugiyama CAMK4 CAMK CAMK-GR CAMKIV GsAsssHGsIQEsHKAsRDPsPIQDGNEDMKAIPEGEKIQG
Q16566 S58 Sugiyama CAMK4 CAMK CAMK-GR CAMKIV NRDALSDFFEVESELGRGAtsIVYRCKQKGTQKPYALKVLK
Q16566 T312 Sugiyama CAMK4 CAMK CAMK-GR CAMKIV FQALQHPWVTGKAANFVHMDtAQKKLQEFNARRKLKAAVKA
Q16566 T57 Sugiyama CAMK4 CAMK CAMK-GR CAMKIV SNRDALSDFFEVESELGRGAtsIVYRCKQKGTQKPYALKVL
Q16576 S146 Sugiyama RBBP7 RBAP46 VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q3KQU3 S112 Sugiyama MAP7D1 KIAA1187 PARCC1 RPRC1 PP2464 KsRGPtPPAMGPRDARPPRRssQPsPtAVPAsDsPPtKQEV
Q3SY84 S143 Sugiyama KRT71 K6IRS1 KB34 KRT6IRS1 IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q5QNW6 S39 Sugiyama H2BC18 HIST2H2BF VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q5UIP0 S1688 Sugiyama RIF1 PVPESNLRTRNAIKRLHKRDsFDNCsLGESSKIGIsDIssL
Q5VT52 S1070 Sugiyama RPRD2 KIAA0460 HSPC099 TATDQQQQEEHYRIETRVsssCLDLPDSTEEKGAPIETLGy
Q5XKE5 S155 Sugiyama KRT79 K6L KB38 KRT6L IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q7RTS7 S153 Sugiyama KRT74 K6IRS4 KB37 KRT5C KRT6IRS4 IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z417 S652 Sugiyama NUFIP2 KIAA1321 PIG1 NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z5L9 S15 Sugiyama IRF2BP2 ______MAAAVAVAAASRRQsCyLCDLPRMPWAMIWDFTEP
Q7Z794 S177 Sugiyama KRT77 KRT1B IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86V81 S239 Sugiyama ALYREF ALY BEF THOC4 tRGGARGRGRGAGRNSKQQLsAEELDAQLDAyNARMDts__
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q86Y46 S145 Sugiyama KRT73 K6IRS3 KB36 KRT6IRS3 IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8IWX8 S904 Sugiyama CHERP DAN26 SCAF6 KGVGVALDDPyENyRRNKsysFIARMKARDECK________
Q8N8S7 S125 Sugiyama ENAH MENA MHALEVLNSQETGPTLPRQNsQLPAQVQNGPSQEELEIQRR
Q8NBJ7 S256 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8ND56 S368 Sugiyama LSM14A C19orf13 FAM61A RAP55 RAP55A EGNADEEDPLGPNCYYDKTKsFFDNIsCDDNRERRPtWAEE
Q8NFH8 S631 Sugiyama REPS2 POB1 AIQTAIRKNKEANAVLARLNsELQQQLKEVHQERIALENQL
Q8WWI1 S706 Sugiyama LMO7 FBX20 FBXO20 KIAA0858 RLMVERLFQKIYGENGsKsMsDVsAEDVQNLRQLRYEEMQK
Q92793 S302 GPS6|SIGNOR|ELM|iPTMNet|EPSD CREBBP CBP QAGGQPMGATGVNPQLASKQsMVNSLPTFPTDIKNTSVTNV
Q93079 S39 Sugiyama H2BC9 H2BFJ HIST1H2BH VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q96D71 S767 Sugiyama REPS1 AIQAsIRRNKETNTVLARLNsELQQQLKDVLEERISLEVQL
Q99575 S816 Sugiyama POP1 KIAA0061 VAATGSHLCVLRSRKLLKQLsAWCGPSSEDSRGGRRAPGRG
Q99618 S94 Sugiyama CDCA3 C8 GRCC8 TOME1 ARtPMKTSsGDPPsPLVKQLsEVFETEDSKSNLPPEPVLPP
Q99623 S91 SIGNOR|EPSD|PSP PHB2 BAP REA RIPWFQYPIIYDIRARPRKIssPTGSKDLQMVNISLRVLSR
Q99877 S39 Sugiyama H2BC15 H2BFD HIST1H2BN VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99879 S39 Sugiyama H2BC14 H2BFE HIST1H2BM INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99880 S39 Sugiyama H2BC13 H2BFC HIST1H2BL VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q9C0C2 S429 Sugiyama TNKS1BP1 KIAA1741 TAB182 EEEAKGDAHLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAA
Q9H6S3 S693 Sugiyama EPS8L2 EPS8R2 PP13181 EGVRVySQLTMQKAFLEKQQsGSELEELMNKFHSMNQRRGE
Q9H788 S315 Sugiyama SH2D4A PPP1R38 SH2A LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9H7D7 S123 Sugiyama WDR26 CDW2 MIP2 PRO0852 SSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLNQT
Q9NSB2 S178 Sugiyama KRT84 KRTHB4 AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9NYF8 S319 Sugiyama BCLAF1 BTF KIAA0164 RsPAKtIAPQNAPRDEsRGRssFyPDGGDQETAKtGKFLKR
Q9UHX1 S461 Sugiyama PUF60 FIR ROBPI SIAHBP1 sIsGssARHMVMQKLLRKQEsTVMVLRNMVDPKDIDDDLEG
Q9ULL1 S611 Sugiyama PLEKHG1 KIAA1209 GQMESTETSSSGHRIVRRAssAGEsNtCPPEIGTSDRTREL
Q9UNH7 S316 Sugiyama SNX6 LKYYLRESQAAKDLLYRRsRsLVDYENANKALDKARAKNKD
Q9UNW9 S194 SIGNOR|PSP NOVA2 ANOVA NOVA3 NLQERVVTVSGEPEQVHKAVsAIVQKVQEDPQSSSCLNISY
Q9UNW9 S25 SIGNOR|PSP NOVA2 ANOVA NOVA3 APDSRKRPLETPPEVVCTKRsNtGEEGEYFLKVLIPSYAAG
Q9UNW9 T27 SIGNOR|PSP NOVA2 ANOVA NOVA3 DSRKRPLETPPEVVCTKRsNtGEEGEYFLKVLIPSYAAGSI
Q9UQ35 S1539 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sEssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEs
Q9UQ35 S1541 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDs
Q9UQ35 S2692 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9UQL6 S259 GPS6|SIGNOR|ELM|EPSD|PSP HDAC5 KIAA0600 KLPLPGPYDSRDDFPLRKTAsEPNLKVRSRLKQKVAERRss
Q9UQL6 S498 GPS6|SIGNOR|ELM|EPSD|PSP HDAC5 KIAA0600 ATSMRTVGKLPRHRPLSRtQssPLPQSPQALQQLVMQQQHQ
Q9Y2B0 S115 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 QIDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKF
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y3U8 S91 Sugiyama RPL36 KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Q9Y6J0 S2126 GPS6 CABIN1 KIAA0330 SGSAQPPEGHPGKPEPSRAKsRPLPNMPKLVIPSAATKFPP
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Chromatin modifying enzymes R-HSA-3247509 6.522843e-10 9.186 0 0
Chromatin organization R-HSA-4839726 7.158209e-09 8.145 0 0
HSF1-dependent transactivation R-HSA-3371571 3.152901e-08 7.501 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 9.166476e-08 7.038 0 0
Attenuation phase R-HSA-3371568 3.049175e-07 6.516 0 0
Diseases of programmed cell death R-HSA-9645723 4.618537e-07 6.335 0 0
NRAGE signals death through JNK R-HSA-193648 5.282503e-07 6.277 0 0
Signal Transduction R-HSA-162582 5.580708e-07 6.253 1 0
Meiotic synapsis R-HSA-1221632 7.048567e-07 6.152 0 0
Cell Cycle R-HSA-1640170 8.434443e-07 6.074 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 9.104246e-07 6.041 0 0
HATs acetylate histones R-HSA-3214847 1.126335e-06 5.948 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.665037e-06 5.436 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.915019e-06 5.308 0 0
Packaging Of Telomere Ends R-HSA-171306 5.250808e-06 5.280 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 5.595321e-06 5.252 0 0
G alpha (12/13) signalling events R-HSA-416482 5.595321e-06 5.252 0 0
Cell Cycle Checkpoints R-HSA-69620 5.955068e-06 5.225 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 6.691958e-06 5.174 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 8.656726e-06 5.063 0 0
DNA methylation R-HSA-5334118 1.109299e-05 4.955 0 0
Cellular Senescence R-HSA-2559583 1.321924e-05 4.879 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.387654e-05 4.858 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.675827e-05 4.776 0 0
Nucleosome assembly R-HSA-774815 2.273295e-05 4.643 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 2.273295e-05 4.643 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.217410e-05 4.654 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 2.326423e-05 4.633 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.419507e-05 4.616 0 0
Cell Cycle, Mitotic R-HSA-69278 3.323903e-05 4.478 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 4.218716e-05 4.375 0 0
HSF1 activation R-HSA-3371511 4.259735e-05 4.371 0 0
PRC2 methylates histones and DNA R-HSA-212300 4.259735e-05 4.371 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 4.192755e-05 4.378 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 4.192755e-05 4.378 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 4.218716e-05 4.375 0 0
Axon guidance R-HSA-422475 4.160511e-05 4.381 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 4.935121e-05 4.307 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 5.334486e-05 4.273 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 5.624588e-05 4.250 0 0
Cleavage of the damaged purine R-HSA-110331 5.679772e-05 4.246 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 5.960464e-05 4.225 0 0
Nervous system development R-HSA-9675108 6.530872e-05 4.185 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 7.379995e-05 4.132 0 0
Depurination R-HSA-73927 7.503641e-05 4.125 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 7.890541e-05 4.103 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 7.890541e-05 4.103 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 8.675714e-05 4.062 0 0
Signaling downstream of RAS mutants R-HSA-9649948 8.675714e-05 4.062 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 8.675714e-05 4.062 0 0
Signaling by RAS mutants R-HSA-6802949 8.675714e-05 4.062 0 0
HDACs deacetylate histones R-HSA-3214815 9.151250e-05 4.039 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.113247e-04 3.953 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.316088e-04 3.881 0 0
M Phase R-HSA-68886 1.428700e-04 3.845 0 0
Meiosis R-HSA-1500620 1.357826e-04 3.867 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.419022e-04 3.848 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.488470e-04 3.827 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.577381e-04 3.802 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.643527e-04 3.784 0 0
Cellular response to heat stress R-HSA-3371556 1.791026e-04 3.747 0 0
Death Receptor Signaling R-HSA-73887 1.799572e-04 3.745 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.869073e-04 3.728 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.997502e-04 3.700 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.502893e-04 3.602 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 2.665148e-04 3.574 0 0
Depyrimidination R-HSA-73928 2.665148e-04 3.574 0 0
Cell-Cell communication R-HSA-1500931 3.101101e-04 3.508 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.264096e-04 3.486 0 0
Mitotic Prophase R-HSA-68875 3.165191e-04 3.500 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.285010e-04 3.483 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 3.454137e-04 3.462 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 3.392952e-04 3.469 0 0
Defective pyroptosis R-HSA-9710421 3.357296e-04 3.474 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.628325e-04 3.440 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.628325e-04 3.440 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 4.531575e-04 3.344 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 4.654705e-04 3.332 0 0
Mitotic Spindle Checkpoint R-HSA-69618 4.764864e-04 3.322 0 0
Post NMDA receptor activation events R-HSA-438064 4.963520e-04 3.304 1 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 5.106395e-04 3.292 0 0
Signaling by RAF1 mutants R-HSA-9656223 5.832227e-04 3.234 0 0
Rap1 signalling R-HSA-392517 6.004459e-04 3.222 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 6.373661e-04 3.196 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 6.284633e-04 3.202 0 0
Cell junction organization R-HSA-446728 6.458074e-04 3.190 0 0
Regulation of TP53 Activity R-HSA-5633007 6.615102e-04 3.179 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 7.866399e-04 3.104 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 8.096853e-04 3.092 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 8.363286e-04 3.078 0 0
Muscle contraction R-HSA-397014 8.976379e-04 3.047 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 9.142352e-04 3.039 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 9.329725e-04 3.030 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 9.347513e-04 3.029 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.101356e-03 2.958 0 0
Neurodegenerative Diseases R-HSA-8863678 1.111751e-03 2.954 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.111751e-03 2.954 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.111225e-03 2.954 0 0
Activation of RAC1 R-HSA-428540 1.271621e-03 2.896 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.258889e-03 2.900 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.249086e-03 2.903 0 0
MAPK family signaling cascades R-HSA-5683057 1.283815e-03 2.891 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.224137e-03 2.912 0 0
Signaling by VEGF R-HSA-194138 1.285212e-03 2.891 0 0
HDMs demethylate histones R-HSA-3214842 1.458505e-03 2.836 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 1.566796e-03 2.805 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.690440e-03 2.772 0 0
CREB phosphorylation R-HSA-199920 1.690440e-03 2.772 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.524084e-03 2.817 0 0
Cardiac conduction R-HSA-5576891 1.523412e-03 2.817 0 0
Apoptotic execution phase R-HSA-75153 1.630612e-03 2.788 0 0
Meiotic recombination R-HSA-912446 1.698659e-03 2.770 0 0
Ion homeostasis R-HSA-5578775 1.741894e-03 2.759 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.756040e-03 2.755 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.987562e-03 2.702 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 2.029070e-03 2.693 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.381091e-03 2.623 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.381091e-03 2.623 1 1
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 2.381091e-03 2.623 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.433740e-03 2.614 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.475140e-03 2.606 0 0
Signaling by ROBO receptors R-HSA-376176 2.826488e-03 2.549 0 0
Rab regulation of trafficking R-HSA-9007101 2.971844e-03 2.527 0 0
Calmodulin induced events R-HSA-111933 2.992302e-03 2.524 1 0
CaM pathway R-HSA-111997 2.992302e-03 2.524 1 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 3.049468e-03 2.516 0 0
DAG and IP3 signaling R-HSA-1489509 3.280905e-03 2.484 1 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.651777e-03 2.437 0 0
DARPP-32 events R-HSA-180024 3.846827e-03 2.415 0 0
Adherens junctions interactions R-HSA-418990 3.940883e-03 2.404 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 4.725369e-03 2.326 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 4.673240e-03 2.330 1 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.598964e-03 2.337 0 0
DNA Double Strand Break Response R-HSA-5693606 4.409767e-03 2.356 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 4.725369e-03 2.326 1 1
Reproduction R-HSA-1474165 4.402986e-03 2.356 0 0
Cell-cell junction organization R-HSA-421270 4.887728e-03 2.311 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 5.124867e-03 2.290 0 0
Semaphorin interactions R-HSA-373755 5.223662e-03 2.282 0 0
Mitotic Prometaphase R-HSA-68877 5.274189e-03 2.278 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 5.285656e-03 2.277 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 5.325865e-03 2.274 0 0
TRP channels R-HSA-3295583 5.401874e-03 2.267 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 5.550611e-03 2.256 0 0
Deubiquitination R-HSA-5688426 6.433042e-03 2.192 0 0
Netrin-1 signaling R-HSA-373752 6.434302e-03 2.191 0 0
EPHB-mediated forward signaling R-HSA-3928662 6.434302e-03 2.191 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 6.756106e-03 2.170 0 0
Processing of DNA double-strand break ends R-HSA-5693607 6.882800e-03 2.162 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 7.228061e-03 2.141 0 0
Ub-specific processing proteases R-HSA-5689880 7.091646e-03 2.149 0 0
FLT3 Signaling R-HSA-9607240 7.568519e-03 2.121 0 0
RAF/MAP kinase cascade R-HSA-5673001 7.914361e-03 2.102 0 0
Chromosome Maintenance R-HSA-73886 7.955291e-03 2.099 0 0
Estrogen-dependent gene expression R-HSA-9018519 8.469563e-03 2.072 0 0
Regulation of endogenous retroelements R-HSA-9842860 8.534437e-03 2.069 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 8.687447e-03 2.061 1 1
Programmed Cell Death R-HSA-5357801 8.937894e-03 2.049 0 0
MAP2K and MAPK activation R-HSA-5674135 8.941235e-03 2.049 0 0
RNA Polymerase I Transcription R-HSA-73864 9.230086e-03 2.035 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 9.479212e-03 2.023 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 9.816293e-03 2.008 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 9.855378e-03 2.006 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 9.855378e-03 2.006 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 9.855378e-03 2.006 0 0
Ca-dependent events R-HSA-111996 1.050302e-02 1.979 1 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.156198e-02 1.937 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.156198e-02 1.937 0 0
Long-term potentiation R-HSA-9620244 1.168457e-02 1.932 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.078753e-02 1.967 0 0
Co-stimulation by CD28 R-HSA-389356 1.198190e-02 1.921 0 0
Signaling by Hippo R-HSA-2028269 1.199737e-02 1.921 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.201613e-02 1.920 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 1.226176e-02 1.911 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.243938e-02 1.905 0 0
RAF activation R-HSA-5673000 1.244174e-02 1.905 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.257737e-02 1.900 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.257737e-02 1.900 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.257737e-02 1.900 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.353935e-02 1.868 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.359988e-02 1.866 0 0
RMTs methylate histone arginines R-HSA-3214858 1.426060e-02 1.846 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.471474e-02 1.832 0 0
ESR-mediated signaling R-HSA-8939211 1.473169e-02 1.832 0 0
G2/M Checkpoints R-HSA-69481 1.494964e-02 1.825 0 0
DCC mediated attractive signaling R-HSA-418885 1.701000e-02 1.769 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.744224e-02 1.758 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.732862e-02 1.761 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.558064e-02 1.807 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.651390e-02 1.782 0 0
Telomere Maintenance R-HSA-157579 1.617448e-02 1.791 0 0
Cellular responses to stimuli R-HSA-8953897 1.744416e-02 1.758 0 0
Apoptosis R-HSA-109581 1.772379e-02 1.751 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.803023e-02 1.744 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.848015e-02 1.733 0 0
Type I hemidesmosome assembly R-HSA-446107 1.870119e-02 1.728 0 0
RSK activation R-HSA-444257 1.870119e-02 1.728 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 1.870119e-02 1.728 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.870119e-02 1.728 1 1
Integrin signaling R-HSA-354192 2.060666e-02 1.686 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 2.063781e-02 1.685 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.092826e-02 1.679 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.092826e-02 1.679 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 2.173517e-02 1.663 0 0
Cellular responses to stress R-HSA-2262752 2.269541e-02 1.644 0 0
Centrosome maturation R-HSA-380287 2.295204e-02 1.639 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 2.353321e-02 1.628 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.357434e-02 1.628 0 0
Amyloid fiber formation R-HSA-977225 2.373385e-02 1.625 0 0
Striated Muscle Contraction R-HSA-390522 2.417468e-02 1.617 0 0
Signaling by LTK R-HSA-9842663 2.422716e-02 1.616 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.438321e-02 1.613 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.456843e-02 1.610 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 2.522710e-02 1.598 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 2.591383e-02 1.586 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.832732e-02 1.548 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.838596e-02 1.547 0 0
Assembly of the pre-replicative complex R-HSA-68867 2.992774e-02 1.524 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.035682e-02 1.518 0 0
Separation of Sister Chromatids R-HSA-2467813 3.112805e-02 1.507 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 3.118455e-02 1.506 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.119541e-02 1.506 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.119541e-02 1.506 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.119541e-02 1.506 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.119541e-02 1.506 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.119541e-02 1.506 0 0
PLC beta mediated events R-HSA-112043 3.137810e-02 1.503 1 0
Axonal growth stimulation R-HSA-209563 3.213059e-02 1.493 0 0
FOXO-mediated transcription R-HSA-9614085 3.297214e-02 1.482 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.376766e-02 1.471 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.392206e-02 1.470 0 0
DNA Double-Strand Break Repair R-HSA-5693532 3.404633e-02 1.468 0 0
Intracellular signaling by second messengers R-HSA-9006925 3.424607e-02 1.465 1 0
Metalloprotease DUBs R-HSA-5689901 3.454506e-02 1.462 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.466884e-02 1.460 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.535567e-02 1.452 0 0
Base Excision Repair R-HSA-73884 3.535567e-02 1.452 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 3.569732e-02 1.447 0 0
RET signaling R-HSA-8853659 3.755096e-02 1.425 0 0
L1CAM interactions R-HSA-373760 3.875073e-02 1.412 0 0
Interaction between L1 and Ankyrins R-HSA-445095 4.057989e-02 1.392 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 4.057989e-02 1.392 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 4.871059e-02 1.312 0 0
Regulation of necroptotic cell death R-HSA-5675482 4.525496e-02 1.344 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 4.297615e-02 1.367 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 4.704336e-02 1.328 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 4.954621e-02 1.305 0 0
Homology Directed Repair R-HSA-5693538 4.492592e-02 1.348 0 0
The NLRP3 inflammasome R-HSA-844456 4.954621e-02 1.305 0 0
EPH-Ephrin signaling R-HSA-2682334 4.572430e-02 1.340 0 0
Opioid Signalling R-HSA-111885 4.934819e-02 1.307 1 0
Cell-extracellular matrix interactions R-HSA-446353 4.871059e-02 1.312 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 5.000002e-02 1.301 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 5.000002e-02 1.301 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 5.000002e-02 1.301 0 0
Regulation of PTEN localization R-HSA-8948747 5.000002e-02 1.301 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 5.462043e-02 1.263 0 0
Signaling by NTRKs R-HSA-166520 5.492824e-02 1.260 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 5.539125e-02 1.257 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 5.731374e-02 1.242 0 0
G-protein mediated events R-HSA-112040 5.758396e-02 1.240 1 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 5.893760e-02 1.230 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 5.935833e-02 1.227 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 6.249549e-02 1.204 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 6.281793e-02 1.202 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 6.281793e-02 1.202 0 0
Activation of BH3-only proteins R-HSA-114452 6.281793e-02 1.202 0 0
Interleukin-37 signaling R-HSA-9008059 6.281793e-02 1.202 0 0
Generic Transcription Pathway R-HSA-212436 6.289352e-02 1.201 1 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.314834e-02 1.200 0 0
Breakdown of the nuclear lamina R-HSA-352238 6.425120e-02 1.192 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 6.425120e-02 1.192 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 6.425120e-02 1.192 0 0
Mitotic G2-G2/M phases R-HSA-453274 6.475943e-02 1.189 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 6.614827e-02 1.179 0 0
Signaling by ALK in cancer R-HSA-9700206 6.614827e-02 1.179 0 0
Sema4D in semaphorin signaling R-HSA-400685 6.633679e-02 1.178 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 6.935330e-02 1.159 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 7.248557e-02 1.140 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 7.248557e-02 1.140 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 7.248557e-02 1.140 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 7.248557e-02 1.140 0 0
ARMS-mediated activation R-HSA-170984 8.437745e-02 1.074 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 7.099302e-02 1.149 0 0
mRNA 3'-end processing R-HSA-72187 7.358237e-02 1.133 0 0
DNA Replication Pre-Initiation R-HSA-69002 7.588457e-02 1.120 0 0
RNA Polymerase II Transcription R-HSA-73857 8.376353e-02 1.077 1 0
Trafficking of AMPA receptors R-HSA-399719 7.166697e-02 1.145 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 8.109938e-02 1.091 0 0
MyD88-independent TLR4 cascade R-HSA-166166 8.109938e-02 1.091 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 7.809554e-02 1.107 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 7.809554e-02 1.107 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 7.809554e-02 1.107 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 7.248557e-02 1.140 0 0
Response of endothelial cells to shear stress R-HSA-9860931 7.702247e-02 1.113 0 0
Recycling pathway of L1 R-HSA-437239 7.992073e-02 1.097 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 8.437745e-02 1.074 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 8.437745e-02 1.074 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 8.531485e-02 1.069 1 0
Signaling by WNT R-HSA-195721 8.618814e-02 1.065 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 8.642881e-02 1.063 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 8.642881e-02 1.063 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 8.642881e-02 1.063 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 8.642881e-02 1.063 0 0
MTOR signalling R-HSA-165159 8.684161e-02 1.061 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 8.724439e-02 1.059 0 0
G-protein beta:gamma signalling R-HSA-397795 9.157143e-02 1.038 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 9.157143e-02 1.038 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 9.157143e-02 1.038 0 0
DNA Repair R-HSA-73894 9.228312e-02 1.035 0 0
Gene expression (Transcription) R-HSA-74160 9.308863e-02 1.031 1 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.439471e-02 1.025 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 9.591458e-02 1.018 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 9.822522e-02 1.008 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 9.822522e-02 1.008 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 9.822522e-02 1.008 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 9.822522e-02 1.008 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 9.822522e-02 1.008 0 0
Signaling by MAPK mutants R-HSA-9652817 9.822522e-02 1.008 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 9.894682e-02 1.005 0 0
Chaperone Mediated Autophagy R-HSA-9613829 9.894682e-02 1.005 0 0
Synaptic adhesion-like molecules R-HSA-8849932 9.894682e-02 1.005 0 0
PKA activation R-HSA-163615 9.894682e-02 1.005 0 0
Ephrin signaling R-HSA-3928664 9.894682e-02 1.005 0 0
PKA activation in glucagon signalling R-HSA-164378 9.894682e-02 1.005 0 0
Regulation of TP53 Expression R-HSA-6804754 1.046739e-01 0.980 0 0
Regulation of cortical dendrite branching R-HSA-8985801 1.046739e-01 0.980 0 0
Potassium transport channels R-HSA-1296067 1.046739e-01 0.980 0 0
Formation of apoptosome R-HSA-111458 1.049434e-01 0.979 0 0
Regulation of the apoptosome activity R-HSA-9627069 1.049434e-01 0.979 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.034675e-01 0.985 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.034675e-01 0.985 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.220313e-01 0.914 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.220313e-01 0.914 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.146227e-01 0.941 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.265687e-01 0.898 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.236211e-01 0.908 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.245298e-01 0.905 0 0
p75NTR signals via NF-kB R-HSA-193639 1.220313e-01 0.914 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.067481e-01 0.972 0 0
Germ layer formation at gastrulation R-HSA-9754189 1.146227e-01 0.941 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.163994e-01 0.934 0 0
Signal attenuation R-HSA-74749 1.049434e-01 0.979 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 1.049434e-01 0.979 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.144050e-01 0.942 0 0
Effects of PIP2 hydrolysis R-HSA-114508 1.026257e-01 0.989 0 0
Generation of second messenger molecules R-HSA-202433 1.158832e-01 0.936 0 0
Neurexins and neuroligins R-HSA-6794361 1.265687e-01 0.898 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.067529e-01 0.972 0 0
Mitotic Anaphase R-HSA-68882 1.022063e-01 0.991 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.022257e-01 0.990 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.062141e-01 0.974 0 0
G2/M Transition R-HSA-69275 1.114096e-01 0.953 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.220313e-01 0.914 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.115658e-01 0.952 0 0
Regulation of gene expression in beta cells R-HSA-210745 1.115658e-01 0.952 0 0
Signalling to ERKs R-HSA-187687 1.268957e-01 0.897 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.270670e-01 0.896 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 1.270670e-01 0.896 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 1.270670e-01 0.896 0 0
Nef and signal transduction R-HSA-164944 1.270670e-01 0.896 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.275433e-01 0.894 0 0
Interleukin-2 signaling R-HSA-9020558 1.275433e-01 0.894 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.277567e-01 0.894 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.277567e-01 0.894 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.277567e-01 0.894 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.277567e-01 0.894 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.314659e-01 0.881 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.314659e-01 0.881 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.314659e-01 0.881 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.314659e-01 0.881 0 0
Formation of definitive endoderm R-HSA-9823730 1.314659e-01 0.881 0 0
Nephrin family interactions R-HSA-373753 1.314659e-01 0.881 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.334271e-01 0.875 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.339347e-01 0.873 0 0
Signaling by Interleukins R-HSA-449147 1.345589e-01 0.871 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.374128e-01 0.862 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.398710e-01 0.854 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.398710e-01 0.854 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.406954e-01 0.852 0 0
Neuronal System R-HSA-112316 1.414819e-01 0.849 1 0
Phase 4 - resting membrane potential R-HSA-5576886 1.420213e-01 0.848 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.420213e-01 0.848 0 0
Prolonged ERK activation events R-HSA-169893 1.420213e-01 0.848 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 1.420213e-01 0.848 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.438296e-01 0.842 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.500432e-01 0.824 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.500432e-01 0.824 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 1.500432e-01 0.824 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.584967e-01 0.800 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.584967e-01 0.800 0 0
SOS-mediated signalling R-HSA-112412 1.584967e-01 0.800 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.919918e-01 0.717 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 1.919918e-01 0.717 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 1.519721e-01 0.818 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.519721e-01 0.818 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.519721e-01 0.818 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.780029e-01 0.750 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 1.780029e-01 0.750 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.780029e-01 0.750 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.780029e-01 0.750 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.780029e-01 0.750 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.780029e-01 0.750 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.780029e-01 0.750 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.633217e-01 0.787 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.633217e-01 0.787 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.858029e-01 0.731 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.883136e-01 0.725 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.701038e-01 0.769 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.701038e-01 0.769 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 1.541574e-01 0.812 0 0
HIV elongation arrest and recovery R-HSA-167287 1.880677e-01 0.726 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.880677e-01 0.726 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 1.862632e-01 0.730 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.835356e-01 0.736 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.573478e-01 0.803 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.762069e-01 0.754 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.571978e-01 0.804 0 0
mRNA Splicing R-HSA-72172 1.852146e-01 0.732 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.780029e-01 0.750 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 1.633217e-01 0.787 0 0
Signaling by ERBB2 R-HSA-1227986 1.462309e-01 0.835 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.883136e-01 0.725 0 0
G0 and Early G1 R-HSA-1538133 1.541574e-01 0.812 0 0
TCR signaling R-HSA-202403 1.718962e-01 0.765 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.684289e-01 0.774 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 1.584967e-01 0.800 0 0
Adrenoceptors R-HSA-390696 1.919918e-01 0.717 0 0
NF-kB is activated and signals survival R-HSA-209560 1.519721e-01 0.818 0 0
ERK/MAPK targets R-HSA-198753 1.494132e-01 0.826 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.698654e-01 0.770 0 0
Regulated Necrosis R-HSA-5218859 1.649259e-01 0.783 0 0
mTORC1-mediated signalling R-HSA-166208 1.883136e-01 0.725 0 0
TBC/RABGAPs R-HSA-8854214 1.662329e-01 0.779 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.504112e-01 0.823 0 0
Kinesins R-HSA-983189 1.462309e-01 0.835 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 1.688889e-01 0.772 0 0
Glycolysis R-HSA-70171 1.921483e-01 0.716 0 0
Inflammasomes R-HSA-622312 1.880677e-01 0.726 0 0
Stimuli-sensing channels R-HSA-2672351 1.545967e-01 0.811 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.493228e-01 0.826 1 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.919918e-01 0.717 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.448480e-01 0.839 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.391980e-01 0.621 0 0
Defective Mismatch Repair Associated With MSH3 R-HSA-5632927 2.391980e-01 0.621 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.391980e-01 0.621 0 0
Defective SLC26A4 causes Pendred syndrome (PDS) R-HSA-5619046 2.391980e-01 0.621 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.391980e-01 0.621 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.391980e-01 0.621 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.391980e-01 0.621 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.391980e-01 0.621 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.391980e-01 0.621 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.391980e-01 0.621 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.984368e-01 0.702 0 0
HCN channels R-HSA-1296061 1.984368e-01 0.702 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.984368e-01 0.702 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 1.984368e-01 0.702 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.984368e-01 0.702 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 1.984368e-01 0.702 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.984368e-01 0.702 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 3.364068e-01 0.473 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.364068e-01 0.473 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 3.364068e-01 0.473 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.364068e-01 0.473 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 3.364068e-01 0.473 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.364068e-01 0.473 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 3.364068e-01 0.473 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.364068e-01 0.473 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.364068e-01 0.473 0 0
Defective SLC12A3 causes Gitelman syndrome (GS) R-HSA-5619087 3.364068e-01 0.473 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.364068e-01 0.473 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.364068e-01 0.473 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 3.364068e-01 0.473 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 3.364068e-01 0.473 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 3.364068e-01 0.473 0 0
Intestinal infectious diseases R-HSA-8942233 3.364068e-01 0.473 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.364068e-01 0.473 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 2.483423e-01 0.605 0 0
IRS activation R-HSA-74713 2.483423e-01 0.605 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.483423e-01 0.605 0 0
G2 Phase R-HSA-68911 2.483423e-01 0.605 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 2.483423e-01 0.605 0 0
p75NTR regulates axonogenesis R-HSA-193697 2.270432e-01 0.644 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 2.270432e-01 0.644 0 0
Regulated proteolysis of p75NTR R-HSA-193692 2.270432e-01 0.644 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.270432e-01 0.644 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 2.985842e-01 0.525 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.985842e-01 0.525 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 2.985842e-01 0.525 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 2.985842e-01 0.525 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 4.212000e-01 0.376 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.212000e-01 0.376 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 4.212000e-01 0.376 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 4.212000e-01 0.376 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 4.212000e-01 0.376 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 4.212000e-01 0.376 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 4.212000e-01 0.376 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 4.212000e-01 0.376 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 4.212000e-01 0.376 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 4.212000e-01 0.376 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 4.212000e-01 0.376 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 4.212000e-01 0.376 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 4.212000e-01 0.376 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 4.212000e-01 0.376 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.212000e-01 0.376 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.212000e-01 0.376 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 4.212000e-01 0.376 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 4.212000e-01 0.376 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.212000e-01 0.376 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 4.212000e-01 0.376 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.212000e-01 0.376 0 0
CD28 dependent Vav1 pathway R-HSA-389359 2.053957e-01 0.687 0 0
Formation of axial mesoderm R-HSA-9796292 2.053957e-01 0.687 0 0
PI3K/AKT activation R-HSA-198203 2.631703e-01 0.580 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 3.482622e-01 0.458 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 3.482622e-01 0.458 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.482622e-01 0.458 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 2.999306e-01 0.523 0 0
PECAM1 interactions R-HSA-210990 2.999306e-01 0.523 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 2.999306e-01 0.523 0 0
Signaling by APC mutants R-HSA-4839744 2.999306e-01 0.523 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.999306e-01 0.523 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.999306e-01 0.523 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.999306e-01 0.523 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.632874e-01 0.580 0 0
E2F mediated regulation of DNA replication R-HSA-113510 2.337443e-01 0.631 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.337443e-01 0.631 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 2.090923e-01 0.680 0 0
Late endosomal microautophagy R-HSA-9615710 2.067636e-01 0.685 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.067636e-01 0.685 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.589097e-01 0.587 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.589097e-01 0.587 0 0
Phosphorylation of the APC/C R-HSA-176412 2.933037e-01 0.533 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 3.369253e-01 0.472 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 3.369253e-01 0.472 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 3.369253e-01 0.472 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 3.369253e-01 0.472 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.967008e-01 0.402 0 0
TRIF-mediated programmed cell death R-HSA-2562578 3.967008e-01 0.402 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 3.967008e-01 0.402 0 0
Disinhibition of SNARE formation R-HSA-114516 3.967008e-01 0.402 0 0
Recycling of eIF2:GDP R-HSA-72731 3.967008e-01 0.402 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.967008e-01 0.402 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 4.951627e-01 0.305 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.951627e-01 0.305 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.951627e-01 0.305 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 4.951627e-01 0.305 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 4.951627e-01 0.305 0 0
Classical Kir channels R-HSA-1296053 4.951627e-01 0.305 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.951627e-01 0.305 0 0
Phenylketonuria R-HSA-2160456 4.951627e-01 0.305 0 0
Defective HPRT1 disrupts guanine and hypoxanthine salvage R-HSA-9734281 4.951627e-01 0.305 0 0
Invadopodia formation R-HSA-8941237 4.951627e-01 0.305 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.033043e-01 0.692 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.033043e-01 0.692 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.528262e-01 0.597 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.528262e-01 0.597 0 0
TGFBR3 expression R-HSA-9839394 2.528262e-01 0.597 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.528262e-01 0.597 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.846721e-01 0.546 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 2.846721e-01 0.546 0 0
HIV Transcription Elongation R-HSA-167169 1.992180e-01 0.701 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 1.992180e-01 0.701 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.992180e-01 0.701 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 3.237264e-01 0.490 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.755783e-01 0.560 0 0
p75NTR recruits signalling complexes R-HSA-209543 3.738023e-01 0.427 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 3.738023e-01 0.427 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 3.738023e-01 0.427 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.987828e-01 0.525 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 4.434058e-01 0.353 0 0
Formation of annular gap junctions R-HSA-196025 4.434058e-01 0.353 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 4.434058e-01 0.353 0 0
Activation of RAS in B cells R-HSA-1169092 4.434058e-01 0.353 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 4.434058e-01 0.353 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 3.223365e-01 0.492 0 0
Formation of the Early Elongation Complex R-HSA-113418 3.223365e-01 0.492 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.102560e-01 0.387 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.849498e-01 0.415 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.248957e-01 0.648 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.640839e-01 0.439 0 0
Signaling by Erythropoietin R-HSA-9006335 3.461384e-01 0.461 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.461384e-01 0.461 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.554559e-01 0.593 0 0
DAP12 signaling R-HSA-2424491 3.700899e-01 0.432 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.700899e-01 0.432 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 3.908032e-01 0.408 0 0
Deadenylation of mRNA R-HSA-429947 3.908032e-01 0.408 0 0
NRIF signals cell death from the nucleus R-HSA-205043 4.460267e-01 0.351 0 0
cGMP effects R-HSA-418457 4.460267e-01 0.351 0 0
Lipophagy R-HSA-9613354 4.880294e-01 0.312 0 0
Gap junction degradation R-HSA-190873 4.880294e-01 0.312 0 0
CASP8 activity is inhibited R-HSA-5218900 4.880294e-01 0.312 0 0
NADE modulates death signalling R-HSA-205025 5.596778e-01 0.252 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.596778e-01 0.252 0 0
ATP sensitive Potassium channels R-HSA-1296025 5.596778e-01 0.252 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.596778e-01 0.252 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.258909e-01 0.487 0 0
G1/S-Specific Transcription R-HSA-69205 3.739790e-01 0.427 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.038802e-01 0.517 0 0
Tight junction interactions R-HSA-420029 4.174355e-01 0.379 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.765490e-01 0.424 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.912793e-01 0.536 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.912793e-01 0.536 0 0
Erythropoietin activates RAS R-HSA-9027284 4.808979e-01 0.318 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 4.808979e-01 0.318 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 4.808979e-01 0.318 0 0
SHC1 events in EGFR signaling R-HSA-180336 4.808979e-01 0.318 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 4.808979e-01 0.318 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.286347e-01 0.641 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 4.750153e-01 0.323 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 4.750153e-01 0.323 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 5.303412e-01 0.275 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 5.303412e-01 0.275 0 0
Folding of actin by CCT/TriC R-HSA-390450 5.303412e-01 0.275 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 5.303412e-01 0.275 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 5.146935e-01 0.288 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.893946e-01 0.410 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 5.039687e-01 0.298 0 0
Telomere Extension By Telomerase R-HSA-171319 4.957186e-01 0.305 0 0
Translation initiation complex formation R-HSA-72649 4.734873e-01 0.325 0 0
Transcription of the HIV genome R-HSA-167172 4.654824e-01 0.332 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 4.654824e-01 0.332 0 0
HCMV Early Events R-HSA-9609690 4.069004e-01 0.391 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 5.044726e-01 0.297 0 0
Notch-HLH transcription pathway R-HSA-350054 5.321926e-01 0.274 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 5.472742e-01 0.262 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 5.472742e-01 0.262 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 5.472742e-01 0.262 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.472742e-01 0.262 0 0
Phase 2 - plateau phase R-HSA-5576893 5.472742e-01 0.262 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 5.702033e-01 0.244 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 5.702033e-01 0.244 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 5.702033e-01 0.244 0 0
Formation of a pool of free 40S subunits R-HSA-72689 4.813491e-01 0.318 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 5.108705e-01 0.292 0 0
Neutrophil degranulation R-HSA-6798695 4.342151e-01 0.362 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.456447e-01 0.263 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 5.150146e-01 0.288 0 0
Regulation of CDH1 Function R-HSA-9764561 5.292561e-01 0.276 0 0
Regulation of RAS by GAPs R-HSA-5658442 5.371227e-01 0.270 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 5.276637e-01 0.278 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 5.276637e-01 0.278 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 5.785341e-01 0.238 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 5.562448e-01 0.255 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 4.074352e-01 0.390 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 5.484518e-01 0.261 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 5.209607e-01 0.283 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 5.456447e-01 0.263 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 3.655351e-01 0.437 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.282820e-01 0.484 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 5.785341e-01 0.238 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 5.785341e-01 0.238 0 0
Mismatch Repair R-HSA-5358508 3.849498e-01 0.415 0 0
IGF1R signaling cascade R-HSA-2428924 2.850169e-01 0.545 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.988933e-01 0.524 0 0
Specification of the neural plate border R-HSA-9834899 2.337443e-01 0.631 0 0
Aggrephagy R-HSA-9646399 1.992180e-01 0.701 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 2.745244e-01 0.561 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.093257e-01 0.679 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.567943e-01 0.254 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 2.698409e-01 0.569 0 0
RUNX2 regulates bone development R-HSA-8941326 3.739790e-01 0.427 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.282820e-01 0.484 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 3.543413e-01 0.451 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 3.543413e-01 0.451 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 4.144093e-01 0.383 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 3.223365e-01 0.492 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 5.638295e-01 0.249 0 0
Fanconi Anemia Pathway R-HSA-6783310 4.376783e-01 0.359 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 5.176926e-01 0.286 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 5.176926e-01 0.286 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.793216e-01 0.421 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.209383e-01 0.656 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.987828e-01 0.525 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 4.460267e-01 0.351 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 4.142901e-01 0.383 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.831538e-01 0.316 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 3.802664e-01 0.420 0 0
Frs2-mediated activation R-HSA-170968 2.053957e-01 0.687 0 0
Resolution of D-Loop Structures R-HSA-5693537 3.087308e-01 0.510 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 5.321709e-01 0.274 0 0
Hedgehog 'off' state R-HSA-5610787 5.522462e-01 0.258 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 3.004411e-01 0.522 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.038802e-01 0.517 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 2.270432e-01 0.644 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 2.631703e-01 0.580 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.874555e-01 0.541 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 4.102560e-01 0.387 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 3.849498e-01 0.415 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.484277e-01 0.348 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 5.473935e-01 0.262 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 3.965655e-01 0.402 0 0
Regulation of mitotic cell cycle R-HSA-453276 3.965655e-01 0.402 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.378800e-01 0.624 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.934336e-01 0.405 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 4.180675e-01 0.379 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 4.174355e-01 0.379 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 1.984368e-01 0.702 0 0
Formation of lateral plate mesoderm R-HSA-9758920 2.985842e-01 0.525 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 3.543413e-01 0.451 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 4.434058e-01 0.353 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 4.808979e-01 0.318 0 0
Regulation of CDH11 function R-HSA-9762292 5.303412e-01 0.275 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 3.406114e-01 0.468 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.146935e-01 0.288 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 5.146935e-01 0.288 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 5.472742e-01 0.262 0 0
Apoptotic factor-mediated response R-HSA-111471 3.849498e-01 0.415 0 0
Dopamine receptors R-HSA-390651 1.984368e-01 0.702 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 2.270432e-01 0.644 0 0
Platelet calcium homeostasis R-HSA-418360 2.067636e-01 0.685 0 0
Sodium/Calcium exchangers R-HSA-425561 3.369253e-01 0.472 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 3.967008e-01 0.402 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 3.738023e-01 0.427 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 3.738023e-01 0.427 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 4.434058e-01 0.353 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 4.102560e-01 0.387 0 0
Telomere C-strand synthesis initiation R-HSA-174430 4.808979e-01 0.318 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.374003e-01 0.472 0 0
Signaling by FGFR4 R-HSA-5654743 5.461614e-01 0.263 0 0
Interleukin-1 signaling R-HSA-9020702 5.660470e-01 0.247 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.427870e-01 0.615 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 5.697061e-01 0.244 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.438666e-01 0.353 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.613375e-01 0.336 0 0
Repression of WNT target genes R-HSA-4641265 3.738023e-01 0.427 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.562369e-01 0.448 0 0
TNF signaling R-HSA-75893 5.108705e-01 0.292 0 0
Triglyceride catabolism R-HSA-163560 3.739790e-01 0.427 0 0
G1 Phase R-HSA-69236 5.664427e-01 0.247 0 0
Cyclin D associated events in G1 R-HSA-69231 5.664427e-01 0.247 0 0
Ca2+ pathway R-HSA-4086398 5.489142e-01 0.260 0 0
Signalling to RAS R-HSA-167044 4.750153e-01 0.323 0 0
Potassium Channels R-HSA-1296071 3.934336e-01 0.405 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.322998e-01 0.634 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 5.100241e-01 0.292 0 0
Signaling by WNT in cancer R-HSA-4791275 4.180675e-01 0.379 0 0
Selective autophagy R-HSA-9663891 3.512344e-01 0.454 0 0
Sensory perception of sour taste R-HSA-9729555 1.984368e-01 0.702 0 0
Calcineurin activates NFAT R-HSA-2025928 2.270432e-01 0.644 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 2.339053e-01 0.631 0 0
Abacavir transmembrane transport R-HSA-2161517 3.482622e-01 0.458 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 3.369253e-01 0.472 0 0
Ca2+ activated K+ channels R-HSA-1296052 3.967008e-01 0.402 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 4.434058e-01 0.353 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 4.434058e-01 0.353 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 4.434058e-01 0.353 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 3.700899e-01 0.432 0 0
Activation of ATR in response to replication stress R-HSA-176187 4.419182e-01 0.355 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 4.419182e-01 0.355 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.783815e-01 0.422 0 0
Formation of the posterior neural plate R-HSA-9832991 5.702033e-01 0.244 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 5.785341e-01 0.238 0 0
Regulation of TNFR1 signaling R-HSA-5357905 4.579395e-01 0.339 0 0
Autophagy R-HSA-9612973 4.282796e-01 0.368 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 2.830699e-01 0.548 0 0
Developmental Biology R-HSA-1266738 2.258537e-01 0.646 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.069666e-01 0.684 0 0
Membrane Trafficking R-HSA-199991 2.556727e-01 0.592 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 3.087308e-01 0.510 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 5.456447e-01 0.263 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 2.830699e-01 0.548 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 3.171637e-01 0.499 0 0
Signaling by SCF-KIT R-HSA-1433557 5.461614e-01 0.263 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 2.265111e-01 0.645 0 0
UCH proteinases R-HSA-5689603 3.647885e-01 0.438 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 5.472742e-01 0.262 0 0
DNA Replication R-HSA-69306 3.949641e-01 0.403 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 3.171637e-01 0.499 0 0
Macroautophagy R-HSA-1632852 4.092534e-01 0.388 0 0
Toll-like Receptor Cascades R-HSA-168898 4.287816e-01 0.368 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.467834e-01 0.350 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 1.984368e-01 0.702 0 0
Formation of intermediate mesoderm R-HSA-9761174 2.631703e-01 0.580 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 2.631703e-01 0.580 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.632874e-01 0.580 0 0
Polo-like kinase mediated events R-HSA-156711 3.849498e-01 0.415 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.954006e-01 0.530 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 4.808979e-01 0.318 0 0
FGFR1 mutant receptor activation R-HSA-1839124 4.419182e-01 0.355 0 0
Adaptive Immune System R-HSA-1280218 4.386686e-01 0.358 0 0
MAP kinase activation R-HSA-450294 2.403462e-01 0.619 0 0
Cardiogenesis R-HSA-9733709 2.874555e-01 0.541 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 4.780593e-01 0.321 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.161427e-01 0.665 0 0
Integration of energy metabolism R-HSA-163685 2.111272e-01 0.675 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 2.294696e-01 0.639 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 5.325617e-01 0.274 0 0
Co-inhibition by PD-1 R-HSA-389948 4.467834e-01 0.350 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 3.482622e-01 0.458 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.463340e-01 0.608 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 3.799588e-01 0.420 0 0
Receptor Mediated Mitophagy R-HSA-8934903 5.303412e-01 0.275 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.472742e-01 0.262 0 0
Transmission across Chemical Synapses R-HSA-112315 3.422157e-01 0.466 1 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 2.700406e-01 0.569 0 0
GPVI-mediated activation cascade R-HSA-114604 3.739790e-01 0.427 0 0
Interleukin-2 family signaling R-HSA-451927 3.160521e-01 0.500 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 4.115810e-01 0.386 0 0
DAP12 interactions R-HSA-2172127 5.664427e-01 0.247 0 0
Interleukin-1 family signaling R-HSA-446652 3.090629e-01 0.510 0 0
Interleukin-17 signaling R-HSA-448424 3.802664e-01 0.420 0 0
Nuclear Envelope Breakdown R-HSA-2980766 5.292561e-01 0.276 0 0
Platelet activation, signaling and aggregation R-HSA-76002 4.698114e-01 0.328 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 5.209607e-01 0.283 0 0
Signaling by TGFBR3 R-HSA-9839373 4.579395e-01 0.339 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 4.579395e-01 0.339 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 4.579395e-01 0.339 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 5.119824e-01 0.291 0 0
NGF-stimulated transcription R-HSA-9031628 3.592262e-01 0.445 0 0
MTF1 activates gene expression R-HSA-5660489 1.984368e-01 0.702 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 1.984368e-01 0.702 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.483423e-01 0.605 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 2.985842e-01 0.525 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 4.212000e-01 0.376 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.093257e-01 0.679 0 0
Signaling by AXIN mutants R-HSA-4839735 3.369253e-01 0.472 0 0
Signaling by AMER1 mutants R-HSA-4839748 3.369253e-01 0.472 0 0
MET interacts with TNS proteins R-HSA-8875513 4.951627e-01 0.305 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 4.434058e-01 0.353 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 4.434058e-01 0.353 0 0
Regulation by c-FLIP R-HSA-3371378 4.434058e-01 0.353 0 0
Co-stimulation by ICOS R-HSA-9927354 4.434058e-01 0.353 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 3.849498e-01 0.415 0 0
Protein ubiquitination R-HSA-8852135 2.511536e-01 0.600 0 0
Regulation of KIT signaling R-HSA-1433559 4.460267e-01 0.351 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 4.880294e-01 0.312 0 0
Transmission across Electrical Synapses R-HSA-112307 5.596778e-01 0.252 0 0
Alanine metabolism R-HSA-8964540 5.596778e-01 0.252 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 5.596778e-01 0.252 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 5.596778e-01 0.252 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.596778e-01 0.252 0 0
GPER1 signaling R-HSA-9634597 3.592262e-01 0.445 0 0
Cristae formation R-HSA-8949613 4.699924e-01 0.328 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.146935e-01 0.288 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 4.524110e-01 0.344 0 0
Disorders of Developmental Biology R-HSA-9675151 5.472742e-01 0.262 1 0
Ionotropic activity of kainate receptors R-HSA-451306 5.702033e-01 0.244 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.567943e-01 0.254 0 0
Cilium Assembly R-HSA-5617833 5.679776e-01 0.246 0 0
Signaling by PTK6 R-HSA-8848021 3.799588e-01 0.420 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.799588e-01 0.420 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 2.755783e-01 0.560 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 2.700406e-01 0.569 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 3.360516e-01 0.474 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 5.146935e-01 0.288 0 0
Diseases of DNA repair R-HSA-9675135 2.098205e-01 0.678 0 0
Heme signaling R-HSA-9707616 2.549415e-01 0.594 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.880294e-01 0.312 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 4.654824e-01 0.332 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 5.472742e-01 0.262 0 0
Regulation of insulin secretion R-HSA-422356 4.214688e-01 0.375 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 3.970499e-01 0.401 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.592262e-01 0.445 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 2.483423e-01 0.605 0 0
Interleukin-1 processing R-HSA-448706 2.270432e-01 0.644 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 4.102560e-01 0.387 0 0
Signal regulatory protein family interactions R-HSA-391160 4.460267e-01 0.351 0 0
Protein hydroxylation R-HSA-9629569 4.454406e-01 0.351 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 5.303412e-01 0.275 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 5.321926e-01 0.274 0 0
Sensory processing of sound R-HSA-9659379 5.262049e-01 0.279 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.041997e-01 0.690 0 0
Gene Silencing by RNA R-HSA-211000 2.794650e-01 0.554 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 5.108705e-01 0.292 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 2.987828e-01 0.525 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.093257e-01 0.679 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 4.808979e-01 0.318 0 0
Ion channel transport R-HSA-983712 3.384810e-01 0.470 0 0
PI Metabolism R-HSA-1483255 2.126248e-01 0.672 0 0
Interleukin-15 signaling R-HSA-8983432 3.738023e-01 0.427 0 0
Ion transport by P-type ATPases R-HSA-936837 3.970499e-01 0.401 0 0
Signaling by NOTCH R-HSA-157118 3.010510e-01 0.521 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.640839e-01 0.439 0 0
Uptake and function of anthrax toxins R-HSA-5210891 5.785341e-01 0.238 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.745244e-01 0.561 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.985842e-01 0.525 0 0
DSCAM interactions R-HSA-376172 4.212000e-01 0.376 0 0
Tandem pore domain potassium channels R-HSA-1296346 2.631703e-01 0.580 0 0
Synthesis of PI R-HSA-1483226 2.999306e-01 0.523 0 0
Alpha-defensins R-HSA-1462054 4.434058e-01 0.353 0 0
Dimerization of procaspase-8 R-HSA-69416 4.434058e-01 0.353 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 2.493228e-01 0.603 0 0
Syndecan interactions R-HSA-3000170 3.640839e-01 0.439 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 3.030861e-01 0.518 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 4.880294e-01 0.312 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 5.596778e-01 0.252 0 0
Negative regulation of FLT3 R-HSA-9706369 5.146935e-01 0.288 0 0
Transport of RCbl within the body R-HSA-9758890 5.702033e-01 0.244 0 0
Glucose metabolism R-HSA-70326 3.403247e-01 0.468 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 5.456447e-01 0.263 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 5.039687e-01 0.298 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 5.254906e-01 0.279 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 5.456447e-01 0.263 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 4.750153e-01 0.323 0 0
Signaling by ALK R-HSA-201556 2.962983e-01 0.528 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 4.419182e-01 0.355 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 5.784670e-01 0.238 0 0
Cytokine Signaling in Immune system R-HSA-1280215 3.074728e-01 0.512 0 0
Formation of the anterior neural plate R-HSA-9823739 4.808979e-01 0.318 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 5.785341e-01 0.238 0 0
Oncogene Induced Senescence R-HSA-2559585 5.119824e-01 0.291 0 0
NrCAM interactions R-HSA-447038 2.483423e-01 0.605 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 2.985842e-01 0.525 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.967008e-01 0.402 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.967008e-01 0.402 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 3.967008e-01 0.402 0 0
Interleukin-18 signaling R-HSA-9012546 4.434058e-01 0.353 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 5.596778e-01 0.252 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 5.596778e-01 0.252 0 0
Signaling by PDGFR in disease R-HSA-9671555 5.039687e-01 0.298 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.438666e-01 0.353 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 2.339053e-01 0.631 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 4.880294e-01 0.312 0 0
Specification of primordial germ cells R-HSA-9827857 3.543413e-01 0.451 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.985842e-01 0.525 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 4.808979e-01 0.318 0 0
Regulation of beta-cell development R-HSA-186712 5.652526e-01 0.248 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 4.655689e-01 0.332 0 0
XBP1(S) activates chaperone genes R-HSA-381038 4.252843e-01 0.371 0 0
IRE1alpha activates chaperones R-HSA-381070 5.150146e-01 0.288 0 0
Interleukin-12 signaling R-HSA-9020591 2.646968e-01 0.577 0 0
HDL assembly R-HSA-8963896 4.460267e-01 0.351 0 0
Signaling by Leptin R-HSA-2586552 5.303412e-01 0.275 0 0
Interleukin-12 family signaling R-HSA-447115 4.403536e-01 0.356 0 0
Regulation of PTEN gene transcription R-HSA-8943724 5.828057e-01 0.234 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 5.861048e-01 0.232 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 5.861048e-01 0.232 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 5.861048e-01 0.232 0 0
Signaling by FGFR3 R-HSA-5654741 5.862967e-01 0.232 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 5.862967e-01 0.232 0 0
S Phase R-HSA-69242 5.863801e-01 0.232 0 0
Inwardly rectifying K+ channels R-HSA-1296065 5.930901e-01 0.227 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 5.934333e-01 0.227 0 0
MHC class II antigen presentation R-HSA-2132295 5.982668e-01 0.223 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 5.995927e-01 0.222 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 6.000277e-01 0.222 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 6.000277e-01 0.222 0 0
Aquaporin-mediated transport R-HSA-445717 6.000277e-01 0.222 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 6.006156e-01 0.221 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 6.056899e-01 0.218 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 6.075508e-01 0.216 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 6.075508e-01 0.216 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 6.075508e-01 0.216 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 6.075508e-01 0.216 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 6.075508e-01 0.216 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 6.075508e-01 0.216 0 0
ERKs are inactivated R-HSA-202670 6.075508e-01 0.216 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 6.075508e-01 0.216 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 6.075508e-01 0.216 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 6.083968e-01 0.216 0 0
Platelet sensitization by LDL R-HSA-432142 6.083968e-01 0.216 0 0
Tie2 Signaling R-HSA-210993 6.083968e-01 0.216 0 0
Nephron development R-HSA-9831926 6.083968e-01 0.216 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.116592e-01 0.213 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 6.116592e-01 0.213 0 0
Formation of the nephric duct R-HSA-9830364 6.116592e-01 0.213 0 0
Interleukin-7 signaling R-HSA-1266695 6.116592e-01 0.213 0 0
Nuclear RNA decay R-HSA-9930044 6.157509e-01 0.211 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 6.157509e-01 0.211 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 6.159514e-01 0.210 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 6.159514e-01 0.210 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 6.159514e-01 0.210 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 6.159514e-01 0.210 1 1
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.159514e-01 0.210 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 6.159514e-01 0.210 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 6.159514e-01 0.210 0 0
Activation of AKT2 R-HSA-165158 6.159514e-01 0.210 0 0
Suppression of autophagy R-HSA-9636569 6.159514e-01 0.210 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 6.159514e-01 0.210 0 0
PTK6 Down-Regulation R-HSA-8849472 6.159514e-01 0.210 0 0
Glycogen metabolism R-HSA-8982491 6.201352e-01 0.208 0 0
Diseases of Immune System R-HSA-5260271 6.201352e-01 0.208 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 6.201352e-01 0.208 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 6.300568e-01 0.201 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 6.331584e-01 0.198 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 6.333897e-01 0.198 0 0
G1/S Transition R-HSA-69206 6.340510e-01 0.198 0 0
Myogenesis R-HSA-525793 6.362142e-01 0.196 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 6.362142e-01 0.196 0 0
Eukaryotic Translation Elongation R-HSA-156842 6.363852e-01 0.196 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.368118e-01 0.196 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 6.368118e-01 0.196 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.368118e-01 0.196 0 0
Other interleukin signaling R-HSA-449836 6.368118e-01 0.196 0 0
STING mediated induction of host immune responses R-HSA-1834941 6.368118e-01 0.196 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 6.376516e-01 0.195 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 6.423753e-01 0.192 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 6.423753e-01 0.192 0 0
Leading Strand Synthesis R-HSA-69109 6.423753e-01 0.192 0 0
Polymerase switching R-HSA-69091 6.423753e-01 0.192 0 0
GRB2 events in EGFR signaling R-HSA-179812 6.423753e-01 0.192 0 0
MET activates RAS signaling R-HSA-8851805 6.423753e-01 0.192 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 6.423753e-01 0.192 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 6.423753e-01 0.192 1 0
Pervasive developmental disorders R-HSA-9005895 6.423753e-01 0.192 1 0
Disorders of Nervous System Development R-HSA-9697154 6.423753e-01 0.192 1 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 6.423753e-01 0.192 0 0
Metal ion SLC transporters R-HSA-425410 6.429819e-01 0.192 0 0
SARS-CoV-1-host interactions R-HSA-9692914 6.450490e-01 0.190 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 6.461676e-01 0.190 0 0
Signaling by FGFR1 R-HSA-5654736 6.461676e-01 0.190 0 0
Insulin receptor signalling cascade R-HSA-74751 6.494919e-01 0.187 0 0
PKR-mediated signaling R-HSA-9833482 6.562865e-01 0.183 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 6.587632e-01 0.181 0 0
Mitophagy R-HSA-5205647 6.587632e-01 0.181 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 6.597373e-01 0.181 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 6.597373e-01 0.181 0 0
Insulin processing R-HSA-264876 6.597373e-01 0.181 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 6.608346e-01 0.180 0 0
IRS-mediated signalling R-HSA-112399 6.628458e-01 0.179 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.637512e-01 0.178 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.637512e-01 0.178 0 0
Signaling by NODAL R-HSA-1181150 6.637512e-01 0.178 0 0
Creatine metabolism R-HSA-71288 6.637512e-01 0.178 0 0
Signal transduction by L1 R-HSA-445144 6.637512e-01 0.178 0 0
PKB-mediated events R-HSA-109703 6.650361e-01 0.177 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.650361e-01 0.177 0 0
PDE3B signalling R-HSA-165160 6.650361e-01 0.177 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.650361e-01 0.177 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.650361e-01 0.177 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.650361e-01 0.177 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 6.650361e-01 0.177 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.650361e-01 0.177 0 0
Signaling by MST1 R-HSA-8852405 6.650361e-01 0.177 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.650361e-01 0.177 0 0
Ceramide signalling R-HSA-193681 6.650361e-01 0.177 0 0
Phosphorylation of Emi1 R-HSA-176417 6.650361e-01 0.177 0 0
Formation of the Editosome R-HSA-75094 6.650361e-01 0.177 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 6.650361e-01 0.177 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.650361e-01 0.177 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.650361e-01 0.177 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.650361e-01 0.177 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 6.650361e-01 0.177 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.650361e-01 0.177 0 0
Peptide chain elongation R-HSA-156902 6.731716e-01 0.172 0 0
Acetylcholine binding and downstream events R-HSA-181431 6.747117e-01 0.171 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 6.747117e-01 0.171 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 6.747117e-01 0.171 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 6.747117e-01 0.171 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 6.747117e-01 0.171 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 6.747117e-01 0.171 0 0
Maturation of nucleoprotein R-HSA-9683610 6.747117e-01 0.171 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 6.747117e-01 0.171 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 6.747117e-01 0.171 0 0
PI3K Cascade R-HSA-109704 6.781345e-01 0.169 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 6.790645e-01 0.168 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 6.790645e-01 0.168 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 6.822079e-01 0.166 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 6.822079e-01 0.166 0 0
Pyroptosis R-HSA-5620971 6.822079e-01 0.166 0 0
Signaling by FGFR in disease R-HSA-1226099 6.822150e-01 0.166 0 0
Signaling by ERBB4 R-HSA-1236394 6.822150e-01 0.166 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 6.892064e-01 0.162 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 6.892064e-01 0.162 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 6.892064e-01 0.162 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.892064e-01 0.162 0 0
Basigin interactions R-HSA-210991 6.892064e-01 0.162 0 0
snRNP Assembly R-HSA-191859 6.947581e-01 0.158 0 0
Metabolism of non-coding RNA R-HSA-194441 6.947581e-01 0.158 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.947581e-01 0.158 0 0
Triglyceride metabolism R-HSA-8979227 6.947581e-01 0.158 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 6.963089e-01 0.157 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 6.963089e-01 0.157 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 6.985410e-01 0.156 0 0
FLT3 signaling in disease R-HSA-9682385 6.985410e-01 0.156 0 0
Interferon gamma signaling R-HSA-877300 7.008790e-01 0.154 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 7.036153e-01 0.153 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 7.036153e-01 0.153 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 7.036153e-01 0.153 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 7.046269e-01 0.152 0 0
Removal of the Flap Intermediate R-HSA-69166 7.046269e-01 0.152 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 7.046269e-01 0.152 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 7.046269e-01 0.152 0 0
Signaling by FGFR4 in disease R-HSA-5655291 7.046269e-01 0.152 0 0
Physiological factors R-HSA-5578768 7.046269e-01 0.152 0 0
Zinc transporters R-HSA-435354 7.046269e-01 0.152 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 7.046269e-01 0.152 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 7.078498e-01 0.150 0 0
STAT5 Activation R-HSA-9645135 7.078498e-01 0.150 0 0
Erythropoietin activates STAT5 R-HSA-9027283 7.078498e-01 0.150 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 7.078498e-01 0.150 0 0
NADPH regeneration R-HSA-389542 7.078498e-01 0.150 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 7.078498e-01 0.150 0 0
Lipid particle organization R-HSA-8964572 7.078498e-01 0.150 0 0
Neurofascin interactions R-HSA-447043 7.078498e-01 0.150 0 0
Signaling by NOTCH1 R-HSA-1980143 7.100091e-01 0.149 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 7.110254e-01 0.148 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 7.117376e-01 0.148 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.131849e-01 0.147 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.131849e-01 0.147 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.131849e-01 0.147 0 0
Mitochondrial calcium ion transport R-HSA-8949215 7.131849e-01 0.147 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 7.131849e-01 0.147 0 0
Immune System R-HSA-168256 7.167369e-01 0.145 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.239585e-01 0.140 0 0
Activation of the pre-replicative complex R-HSA-68962 7.239585e-01 0.140 0 0
Cellular response to chemical stress R-HSA-9711123 7.275981e-01 0.138 0 0
Translesion synthesis by REV1 R-HSA-110312 7.322117e-01 0.135 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 7.322117e-01 0.135 0 0
Processive synthesis on the lagging strand R-HSA-69183 7.322117e-01 0.135 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 7.322117e-01 0.135 0 0
p38MAPK events R-HSA-171007 7.322117e-01 0.135 0 0
Spry regulation of FGF signaling R-HSA-1295596 7.322117e-01 0.135 0 0
Biotin transport and metabolism R-HSA-196780 7.322117e-01 0.135 0 0
Other semaphorin interactions R-HSA-416700 7.322117e-01 0.135 0 0
Protein methylation R-HSA-8876725 7.322117e-01 0.135 0 0
MET promotes cell motility R-HSA-8875878 7.349935e-01 0.134 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.357079e-01 0.133 0 0
FGFR2 alternative splicing R-HSA-6803529 7.357079e-01 0.133 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.357079e-01 0.133 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.357079e-01 0.133 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.357079e-01 0.133 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.357079e-01 0.133 0 0
Nuclear Receptor transcription pathway R-HSA-383280 7.362051e-01 0.133 0 0
Platelet homeostasis R-HSA-418346 7.367389e-01 0.133 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 7.371703e-01 0.132 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 7.421072e-01 0.130 0 0
EGFR downregulation R-HSA-182971 7.432441e-01 0.129 0 0
Downstream signal transduction R-HSA-186763 7.432441e-01 0.129 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 7.451934e-01 0.128 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 7.451934e-01 0.128 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.451934e-01 0.128 0 0
Netrin mediated repulsion signals R-HSA-418886 7.451934e-01 0.128 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 7.451934e-01 0.128 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 7.451934e-01 0.128 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 7.451934e-01 0.128 0 0
PTK6 Expression R-HSA-8849473 7.451934e-01 0.128 0 0
mRNA Editing: C to U Conversion R-HSA-72200 7.451934e-01 0.128 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.451934e-01 0.128 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 7.451934e-01 0.128 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 7.451934e-01 0.128 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 7.451934e-01 0.128 0 0
Glycoprotein hormones R-HSA-209822 7.451934e-01 0.128 0 0
CHL1 interactions R-HSA-447041 7.451934e-01 0.128 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 7.451934e-01 0.128 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 7.451934e-01 0.128 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 7.457281e-01 0.127 0 0
Developmental Cell Lineages R-HSA-9734767 7.467033e-01 0.127 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 7.474721e-01 0.126 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 7.478734e-01 0.126 0 0
Hedgehog 'on' state R-HSA-5632684 7.502215e-01 0.125 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 7.519702e-01 0.124 0 0
HCMV Late Events R-HSA-9610379 7.536577e-01 0.123 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 7.559876e-01 0.121 0 0
Signaling by NOTCH3 R-HSA-9012852 7.559876e-01 0.121 0 0
Carnitine shuttle R-HSA-200425 7.568077e-01 0.121 0 0
Growth hormone receptor signaling R-HSA-982772 7.568077e-01 0.121 0 0
Translesion synthesis by POLI R-HSA-5656121 7.575729e-01 0.121 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 7.575729e-01 0.121 0 0
Differentiation of T cells R-HSA-9945266 7.575729e-01 0.121 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 7.575729e-01 0.121 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 7.575729e-01 0.121 0 0
Regulation of BACH1 activity R-HSA-9708530 7.575729e-01 0.121 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 7.575729e-01 0.121 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 7.575729e-01 0.121 0 0
Signaling by FGFR2 R-HSA-5654738 7.607712e-01 0.119 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 7.609450e-01 0.119 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 7.628171e-01 0.118 0 0
HCMV Infection R-HSA-9609646 7.638658e-01 0.117 0 0
Organelle biogenesis and maintenance R-HSA-1852241 7.662213e-01 0.116 1 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 7.681223e-01 0.115 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 7.693593e-01 0.114 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.693593e-01 0.114 0 0
Signaling by EGFR R-HSA-177929 7.698019e-01 0.114 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 7.765253e-01 0.110 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.765253e-01 0.110 0 0
TNFs bind their physiological receptors R-HSA-5669034 7.765253e-01 0.110 0 0
Plasma lipoprotein assembly R-HSA-8963898 7.765253e-01 0.110 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 7.777656e-01 0.109 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.777656e-01 0.109 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 7.777656e-01 0.109 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.777656e-01 0.109 0 0
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597 7.777656e-01 0.109 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.777656e-01 0.109 0 0
Interleukin-9 signaling R-HSA-8985947 7.777656e-01 0.109 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.777656e-01 0.109 0 0
Nucleotide salvage defects R-HSA-9734207 7.777656e-01 0.109 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.777656e-01 0.109 0 0
Sodium/Proton exchangers R-HSA-425986 7.777656e-01 0.109 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 7.787032e-01 0.109 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 7.787032e-01 0.109 0 0
Signaling by TGFB family members R-HSA-9006936 7.787669e-01 0.109 0 0
Eukaryotic Translation Termination R-HSA-72764 7.798609e-01 0.108 0 0
SARS-CoV-1 Infection R-HSA-9678108 7.801813e-01 0.108 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 7.808281e-01 0.107 0 0
Translesion synthesis by POLK R-HSA-5655862 7.808281e-01 0.107 0 0
Synthesis of PG R-HSA-1483148 7.808281e-01 0.107 0 0
Response to metal ions R-HSA-5660526 7.808281e-01 0.107 0 0
Signaling by Hedgehog R-HSA-5358351 7.859765e-01 0.105 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 7.885483e-01 0.103 0 0
Downstream TCR signaling R-HSA-202424 7.919827e-01 0.101 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 7.943139e-01 0.100 0 0
Unfolded Protein Response (UPR) R-HSA-381119 7.943202e-01 0.100 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.949088e-01 0.100 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 7.949088e-01 0.100 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 7.949088e-01 0.100 0 0
G protein gated Potassium channels R-HSA-1296059 7.949088e-01 0.100 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 7.949208e-01 0.100 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 7.949208e-01 0.100 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.949208e-01 0.100 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 7.980022e-01 0.098 0 0
Intra-Golgi traffic R-HSA-6811438 7.980022e-01 0.098 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 7.980022e-01 0.098 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 8.021013e-01 0.096 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 8.021013e-01 0.096 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.021013e-01 0.096 0 0
Kidney development R-HSA-9830369 8.021921e-01 0.096 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 8.028879e-01 0.095 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 8.061756e-01 0.094 0 0
WNT mediated activation of DVL R-HSA-201688 8.061756e-01 0.094 0 0
Unwinding of DNA R-HSA-176974 8.061756e-01 0.094 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 8.061756e-01 0.094 0 0
Regulation of signaling by NODAL R-HSA-1433617 8.061756e-01 0.094 0 0
Degradation of GABA R-HSA-916853 8.061756e-01 0.094 0 0
mRNA Editing R-HSA-75072 8.061756e-01 0.094 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 8.061756e-01 0.094 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 8.061756e-01 0.094 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 8.061756e-01 0.094 0 0
Lysosomal oligosaccharide catabolism R-HSA-8853383 8.061756e-01 0.094 0 0
Cellular response to mitochondrial stress R-HSA-9840373 8.061756e-01 0.094 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 8.061756e-01 0.094 0 0
GP1b-IX-V activation signalling R-HSA-430116 8.061756e-01 0.094 0 0
Extension of Telomeres R-HSA-180786 8.077801e-01 0.093 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.077801e-01 0.093 0 0
G alpha (s) signalling events R-HSA-418555 8.094786e-01 0.092 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.101672e-01 0.091 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.101672e-01 0.091 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.101672e-01 0.091 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.101672e-01 0.091 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 8.117630e-01 0.091 0 0
Signaling by EGFR in Cancer R-HSA-1643713 8.120114e-01 0.090 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.120114e-01 0.090 0 0
Sphingolipid catabolism R-HSA-9845614 8.120114e-01 0.090 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 8.120114e-01 0.090 0 0
GPCR downstream signalling R-HSA-388396 8.156588e-01 0.088 1 0
Gastrulation R-HSA-9758941 8.173687e-01 0.088 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.190275e-01 0.087 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.193111e-01 0.087 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.193314e-01 0.087 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 8.215191e-01 0.085 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 8.215191e-01 0.085 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 8.269933e-01 0.082 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.269933e-01 0.082 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.269933e-01 0.082 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.278903e-01 0.082 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.278903e-01 0.082 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 8.278903e-01 0.082 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 8.278903e-01 0.082 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.278903e-01 0.082 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.302987e-01 0.081 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 8.309080e-01 0.080 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 8.309552e-01 0.080 0 0
2-LTR circle formation R-HSA-164843 8.309552e-01 0.080 0 0
DNA replication initiation R-HSA-68952 8.309552e-01 0.080 0 0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 8.309552e-01 0.080 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.309552e-01 0.080 0 0
Josephin domain DUBs R-HSA-5689877 8.309552e-01 0.080 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 8.309552e-01 0.080 0 0
Arachidonate production from DAG R-HSA-426048 8.309552e-01 0.080 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 8.309552e-01 0.080 0 0
Pexophagy R-HSA-9664873 8.309552e-01 0.080 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 8.309552e-01 0.080 0 0
Maturation of spike protein R-HSA-9683686 8.309552e-01 0.080 0 0
Sperm Motility And Taxes R-HSA-1300642 8.309552e-01 0.080 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 8.309552e-01 0.080 0 0
Peptide hormone biosynthesis R-HSA-209952 8.309552e-01 0.080 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 8.309552e-01 0.080 0 0
Selenocysteine synthesis R-HSA-2408557 8.357768e-01 0.078 0 0
Amine ligand-binding receptors R-HSA-375280 8.370282e-01 0.077 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.378761e-01 0.077 0 0
RNA Polymerase III Transcription R-HSA-74158 8.378761e-01 0.077 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.378761e-01 0.077 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.382828e-01 0.077 0 0
Smooth Muscle Contraction R-HSA-445355 8.382828e-01 0.077 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 8.392080e-01 0.076 0 0
Crosslinking of collagen fibrils R-HSA-2243919 8.392080e-01 0.076 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.392080e-01 0.076 0 0
Maturation of nucleoprotein R-HSA-9694631 8.392080e-01 0.076 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.407451e-01 0.075 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.426048e-01 0.074 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.426048e-01 0.074 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.485796e-01 0.071 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.485796e-01 0.071 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 8.489698e-01 0.071 0 0
Voltage gated Potassium channels R-HSA-1296072 8.504093e-01 0.070 0 0
Viral mRNA Translation R-HSA-192823 8.517952e-01 0.070 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 8.525681e-01 0.069 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 8.525681e-01 0.069 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 8.525681e-01 0.069 0 0
FGFR2b ligand binding and activation R-HSA-190377 8.525681e-01 0.069 0 0
Bicarbonate transporters R-HSA-425381 8.525681e-01 0.069 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.525681e-01 0.069 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 8.525681e-01 0.069 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 8.525681e-01 0.069 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.525681e-01 0.069 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.525681e-01 0.069 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.525681e-01 0.069 0 0
LGI-ADAM interactions R-HSA-5682910 8.525681e-01 0.069 0 0
Mitochondrial biogenesis R-HSA-1592230 8.535681e-01 0.069 1 0
PTEN Regulation R-HSA-6807070 8.544044e-01 0.068 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 8.552928e-01 0.068 0 0
Circadian clock R-HSA-9909396 8.561547e-01 0.067 0 0
mRNA Capping R-HSA-72086 8.562161e-01 0.067 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.562161e-01 0.067 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 8.562161e-01 0.067 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.594436e-01 0.066 0 0
Switching of origins to a post-replicative state R-HSA-69052 8.619981e-01 0.064 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.686117e-01 0.061 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 8.687855e-01 0.061 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.687855e-01 0.061 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 8.696470e-01 0.061 0 0
Lagging Strand Synthesis R-HSA-69186 8.698943e-01 0.061 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 8.698943e-01 0.061 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 8.698943e-01 0.061 0 0
Platelet degranulation R-HSA-114608 8.712376e-01 0.060 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.714188e-01 0.060 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 8.714188e-01 0.060 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.714188e-01 0.060 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.714188e-01 0.060 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.714188e-01 0.060 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.714188e-01 0.060 0 0
Integration of provirus R-HSA-162592 8.714188e-01 0.060 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.714188e-01 0.060 0 0
Uptake of dietary cobalamins into enterocytes R-HSA-9758881 8.714188e-01 0.060 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.723440e-01 0.059 0 0
Stabilization of p53 R-HSA-69541 8.730209e-01 0.059 0 0
Signaling by FGFR R-HSA-190236 8.773479e-01 0.057 0 0
ISG15 antiviral mechanism R-HSA-1169408 8.783410e-01 0.056 0 0
Late Phase of HIV Life Cycle R-HSA-162599 8.788320e-01 0.056 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 8.803742e-01 0.055 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 8.803742e-01 0.055 0 0
Budding and maturation of HIV virion R-HSA-162588 8.803742e-01 0.055 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 8.831288e-01 0.054 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.831767e-01 0.054 0 0
Metabolism of RNA R-HSA-8953854 8.837815e-01 0.054 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.865639e-01 0.052 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.878602e-01 0.052 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.878602e-01 0.052 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.878602e-01 0.052 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.878602e-01 0.052 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 8.878602e-01 0.052 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.878602e-01 0.052 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 8.878602e-01 0.052 0 0
Estrogen biosynthesis R-HSA-193144 8.878602e-01 0.052 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.878602e-01 0.052 0 0
OAS antiviral response R-HSA-8983711 8.878602e-01 0.052 0 0
Leishmania infection R-HSA-9658195 8.880255e-01 0.052 0 0
Parasitic Infection Pathways R-HSA-9824443 8.880255e-01 0.052 0 0
Degradation of CDH1 R-HSA-9766229 8.881807e-01 0.051 0 0
DNA strand elongation R-HSA-69190 8.910427e-01 0.050 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.926176e-01 0.049 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 8.926176e-01 0.049 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.951071e-01 0.048 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 8.951071e-01 0.048 0 0
Signaling by KIT in disease R-HSA-9669938 8.951071e-01 0.048 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 8.951071e-01 0.048 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 8.951071e-01 0.048 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 8.951071e-01 0.048 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.951071e-01 0.048 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.965664e-01 0.047 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.981940e-01 0.047 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 8.990354e-01 0.046 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 9.008500e-01 0.045 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 9.008500e-01 0.045 0 0
Collagen formation R-HSA-1474290 9.011335e-01 0.045 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.013822e-01 0.045 0 0
HIV Transcription Initiation R-HSA-167161 9.013822e-01 0.045 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.013822e-01 0.045 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.013822e-01 0.045 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.013822e-01 0.045 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 9.015362e-01 0.045 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 9.015362e-01 0.045 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 9.015362e-01 0.045 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 9.015362e-01 0.045 0 0
GABA receptor activation R-HSA-977443 9.015362e-01 0.045 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 9.015362e-01 0.045 0 0
FGFR2c ligand binding and activation R-HSA-190375 9.022001e-01 0.045 0 0
FGFR1c ligand binding and activation R-HSA-190373 9.022001e-01 0.045 0 0
Processing of SMDT1 R-HSA-8949664 9.022001e-01 0.045 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 9.022001e-01 0.045 0 0
FGFR4 ligand binding and activation R-HSA-190322 9.022001e-01 0.045 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 9.022001e-01 0.045 0 0
Chylomicron remodeling R-HSA-8963901 9.022001e-01 0.045 0 0
Mtb iron assimilation by chelation R-HSA-1222449 9.022001e-01 0.045 0 0
FGFR3 mutant receptor activation R-HSA-2033514 9.022001e-01 0.045 0 0
Diseases of nucleotide metabolism R-HSA-9735804 9.022001e-01 0.045 0 0
rRNA modification in the mitochondrion R-HSA-6793080 9.022001e-01 0.045 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 9.022001e-01 0.045 0 0
The phototransduction cascade R-HSA-2514856 9.044018e-01 0.044 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.048632e-01 0.043 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.059340e-01 0.043 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.059340e-01 0.043 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 9.059340e-01 0.043 0 0
COPII-mediated vesicle transport R-HSA-204005 9.068907e-01 0.042 0 0
Hemostasis R-HSA-109582 9.091266e-01 0.041 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 9.098533e-01 0.041 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 9.098533e-01 0.041 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.098533e-01 0.041 0 0
Heme degradation R-HSA-189483 9.098533e-01 0.041 0 0
Vesicle-mediated transport R-HSA-5653656 9.105755e-01 0.041 0 0
HIV Life Cycle R-HSA-162587 9.115489e-01 0.040 0 0
Orc1 removal from chromatin R-HSA-68949 9.117142e-01 0.040 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.124964e-01 0.040 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 9.147070e-01 0.039 0 0
Prolactin receptor signaling R-HSA-1170546 9.147070e-01 0.039 0 0
CRMPs in Sema3A signaling R-HSA-399956 9.147070e-01 0.039 0 0
FGFR3c ligand binding and activation R-HSA-190372 9.147070e-01 0.039 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 9.147070e-01 0.039 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 9.147070e-01 0.039 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 9.147070e-01 0.039 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.147070e-01 0.039 0 0
Ciprofloxacin ADME R-HSA-9793528 9.147070e-01 0.039 0 0
P2Y receptors R-HSA-417957 9.147070e-01 0.039 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.157080e-01 0.038 0 0
Cellular response to starvation R-HSA-9711097 9.157653e-01 0.038 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.170338e-01 0.038 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.170338e-01 0.038 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.177516e-01 0.037 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.180315e-01 0.037 1 1
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 9.181079e-01 0.037 0 0
Nuclear import of Rev protein R-HSA-180746 9.181079e-01 0.037 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.185309e-01 0.037 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.185309e-01 0.037 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.239941e-01 0.034 0 0
Clathrin-mediated endocytosis R-HSA-8856828 9.243027e-01 0.034 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.245214e-01 0.034 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.245214e-01 0.034 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 9.256151e-01 0.034 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.256151e-01 0.034 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.256151e-01 0.034 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 9.256151e-01 0.034 0 0
Signaling by Activin R-HSA-1502540 9.256151e-01 0.034 0 0
FGFR3 ligand binding and activation R-HSA-190239 9.256151e-01 0.034 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 9.256151e-01 0.034 0 0
Protein repair R-HSA-5676934 9.256151e-01 0.034 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 9.256151e-01 0.034 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 9.256151e-01 0.034 0 0
DNA Damage Reversal R-HSA-73942 9.256151e-01 0.034 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 9.256667e-01 0.034 0 0
HIV Infection R-HSA-162906 9.288919e-01 0.032 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.304246e-01 0.031 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.307828e-01 0.031 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 9.324598e-01 0.030 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 9.324598e-01 0.030 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 9.324598e-01 0.030 0 0
Abacavir ADME R-HSA-2161522 9.324598e-01 0.030 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.325804e-01 0.030 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.325804e-01 0.030 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.351288e-01 0.029 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.351288e-01 0.029 0 0
Killing mechanisms R-HSA-9664420 9.351288e-01 0.029 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 9.351288e-01 0.029 0 0
Attachment and Entry R-HSA-9678110 9.351288e-01 0.029 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 9.351288e-01 0.029 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.351288e-01 0.029 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 9.351288e-01 0.029 0 0
Activation of SMO R-HSA-5635838 9.351288e-01 0.029 0 0
Fructose catabolism R-HSA-70350 9.351288e-01 0.029 0 0
Synthesis of wybutosine at G37 of tRNA(Phe) R-HSA-6782861 9.351288e-01 0.029 0 0
Atorvastatin ADME R-HSA-9754706 9.351288e-01 0.029 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.363591e-01 0.029 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 9.363591e-01 0.029 0 0
Signaling by Insulin receptor R-HSA-74752 9.367332e-01 0.028 0 0
Degradation of DVL R-HSA-4641258 9.388969e-01 0.027 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.388969e-01 0.027 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 9.388969e-01 0.027 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.396029e-01 0.027 0 0
Parasite infection R-HSA-9664407 9.413041e-01 0.026 0 0
Leishmania phagocytosis R-HSA-9664417 9.413041e-01 0.026 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.413041e-01 0.026 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.434261e-01 0.025 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 9.434261e-01 0.025 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.434261e-01 0.025 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 9.434261e-01 0.025 0 0
Passive transport by Aquaporins R-HSA-432047 9.434261e-01 0.025 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.434261e-01 0.025 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.434261e-01 0.025 0 0
Coenzyme A biosynthesis R-HSA-196783 9.434261e-01 0.025 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.434261e-01 0.025 0 0
Elastic fibre formation R-HSA-1566948 9.446616e-01 0.025 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 9.446616e-01 0.025 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 9.460243e-01 0.024 0 0
Pyrimidine salvage R-HSA-73614 9.460243e-01 0.024 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.460442e-01 0.024 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.460855e-01 0.024 0 0
Potential therapeutics for SARS R-HSA-9679191 9.480963e-01 0.023 0 0
Interferon Signaling R-HSA-913531 9.490168e-01 0.023 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 9.499174e-01 0.022 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.506626e-01 0.022 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.506626e-01 0.022 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.506626e-01 0.022 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.506626e-01 0.022 0 0
Glycogen storage diseases R-HSA-3229121 9.506626e-01 0.022 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.506626e-01 0.022 0 0
Catecholamine biosynthesis R-HSA-209905 9.506626e-01 0.022 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.506626e-01 0.022 0 0
Choline catabolism R-HSA-6798163 9.506626e-01 0.022 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 9.508980e-01 0.022 0 0
DNA Damage Bypass R-HSA-73893 9.515043e-01 0.022 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.517916e-01 0.021 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.517916e-01 0.021 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.535792e-01 0.021 0 0
RAB geranylgeranylation R-HSA-8873719 9.545127e-01 0.020 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.547046e-01 0.020 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 9.547046e-01 0.020 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 9.547046e-01 0.020 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.547046e-01 0.020 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.547046e-01 0.020 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 9.547046e-01 0.020 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 9.547046e-01 0.020 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.551012e-01 0.020 0 0
Signaling by MET R-HSA-6806834 9.553016e-01 0.020 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.569670e-01 0.019 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 9.569738e-01 0.019 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.569738e-01 0.019 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.569738e-01 0.019 0 0
GAB1 signalosome R-HSA-180292 9.569738e-01 0.019 0 0
Activated point mutants of FGFR2 R-HSA-2033519 9.569738e-01 0.019 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.569738e-01 0.019 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.569738e-01 0.019 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.569738e-01 0.019 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.569738e-01 0.019 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.569738e-01 0.019 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.569738e-01 0.019 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.569738e-01 0.019 0 0
Maturation of spike protein R-HSA-9694548 9.590608e-01 0.018 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 9.590608e-01 0.018 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 9.608579e-01 0.017 0 0
Signaling by GPCR R-HSA-372790 9.614828e-01 0.017 1 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.616077e-01 0.017 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.616077e-01 0.017 0 0
Cargo concentration in the ER R-HSA-5694530 9.616077e-01 0.017 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.616077e-01 0.017 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.616077e-01 0.017 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.617212e-01 0.017 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.617212e-01 0.017 0 0
Signaling by PDGF R-HSA-186797 9.617212e-01 0.017 0 0
Regulation of signaling by CBL R-HSA-912631 9.624781e-01 0.017 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 9.624781e-01 0.017 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.624781e-01 0.017 0 0
Synthesis of DNA R-HSA-69239 9.625446e-01 0.017 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.630213e-01 0.016 0 0
Translation of Structural Proteins R-HSA-9683701 9.630213e-01 0.016 0 0
Host Interactions of HIV factors R-HSA-162909 9.635908e-01 0.016 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.645615e-01 0.016 0 0
Activation of GABAB receptors R-HSA-991365 9.666190e-01 0.015 0 0
GABA B receptor activation R-HSA-977444 9.666190e-01 0.015 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.672784e-01 0.014 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.672784e-01 0.014 0 0
Glycogen synthesis R-HSA-3322077 9.672784e-01 0.014 0 0
Pregnenolone biosynthesis R-HSA-196108 9.672784e-01 0.014 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.677434e-01 0.014 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.694883e-01 0.013 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.694883e-01 0.013 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.695747e-01 0.013 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.714649e-01 0.013 0 0
G-protein activation R-HSA-202040 9.714649e-01 0.013 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.714649e-01 0.013 0 0
Phenylalanine metabolism R-HSA-8964208 9.714649e-01 0.013 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.714649e-01 0.013 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.714649e-01 0.013 0 0
Early Phase of HIV Life Cycle R-HSA-162594 9.714649e-01 0.013 0 0
G alpha (q) signalling events R-HSA-416476 9.716341e-01 0.012 0 0
G alpha (z) signalling events R-HSA-418597 9.723339e-01 0.012 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.728192e-01 0.012 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.728192e-01 0.012 0 0
Gap junction trafficking R-HSA-190828 9.728458e-01 0.012 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.728458e-01 0.012 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 9.748573e-01 0.011 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.748573e-01 0.011 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 9.751159e-01 0.011 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.751159e-01 0.011 0 0
Attachment and Entry R-HSA-9694614 9.751159e-01 0.011 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.751159e-01 0.011 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.751159e-01 0.011 0 0
Assembly Of The HIV Virion R-HSA-175474 9.751159e-01 0.011 0 0
Glutathione synthesis and recycling R-HSA-174403 9.751159e-01 0.011 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.753928e-01 0.011 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.755295e-01 0.011 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 9.755295e-01 0.011 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.755295e-01 0.011 0 0
Dual Incision in GG-NER R-HSA-5696400 9.757974e-01 0.011 0 0
eNOS activation R-HSA-203615 9.757974e-01 0.011 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.757974e-01 0.011 0 0
Hyaluronan metabolism R-HSA-2142845 9.757974e-01 0.011 0 0
PCP/CE pathway R-HSA-4086400 9.765648e-01 0.010 0 0
Integrin cell surface interactions R-HSA-216083 9.765648e-01 0.010 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.779598e-01 0.010 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.779598e-01 0.010 0 0
Ribosome-associated quality control R-HSA-9948299 9.780041e-01 0.010 0 0
Nucleotide Excision Repair R-HSA-5696398 9.782637e-01 0.010 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 9.783000e-01 0.010 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.783000e-01 0.010 0 0
Fructose metabolism R-HSA-5652084 9.783000e-01 0.010 0 0
Regulation of Apoptosis R-HSA-169911 9.784587e-01 0.009 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.784587e-01 0.009 0 0
PERK regulates gene expression R-HSA-381042 9.784587e-01 0.009 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.784827e-01 0.009 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.789643e-01 0.009 0 0
Dual incision in TC-NER R-HSA-6782135 9.792692e-01 0.009 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.792692e-01 0.009 0 0
Adipogenesis R-HSA-9843745 9.799894e-01 0.009 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 9.801590e-01 0.009 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 9.802539e-01 0.009 0 0
Glycosphingolipid transport R-HSA-9845576 9.808355e-01 0.008 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.810768e-01 0.008 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.810768e-01 0.008 0 0
Formation of the ureteric bud R-HSA-9830674 9.810768e-01 0.008 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.810768e-01 0.008 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.810768e-01 0.008 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.810768e-01 0.008 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.810768e-01 0.008 0 0
Biosynthesis of maresins R-HSA-9018682 9.810768e-01 0.008 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.811908e-01 0.008 0 0
Neurotransmitter release cycle R-HSA-112310 9.813688e-01 0.008 0 0
Intraflagellar transport R-HSA-5620924 9.821477e-01 0.008 0 0
Gluconeogenesis R-HSA-70263 9.821477e-01 0.008 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.828915e-01 0.007 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.829568e-01 0.007 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.829568e-01 0.007 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.829568e-01 0.007 0 0
Collagen chain trimerization R-HSA-8948216 9.829568e-01 0.007 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 9.834985e-01 0.007 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 9.834985e-01 0.007 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.834985e-01 0.007 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.834985e-01 0.007 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.834985e-01 0.007 0 0
Complex III assembly R-HSA-9865881 9.834985e-01 0.007 0 0
Gap junction trafficking and regulation R-HSA-157858 9.839449e-01 0.007 0 0
Viral Messenger RNA Synthesis R-HSA-168325 9.845400e-01 0.007 0 0
rRNA processing R-HSA-72312 9.845815e-01 0.007 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.848493e-01 0.007 0 0
Influenza Infection R-HSA-168255 9.849100e-01 0.007 0 0
Phospholipid metabolism R-HSA-1483257 9.855373e-01 0.006 0 0
Azathioprine ADME R-HSA-9748787 9.855681e-01 0.006 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.856103e-01 0.006 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.856103e-01 0.006 0 0
Hyaluronan degradation R-HSA-2160916 9.856103e-01 0.006 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.856103e-01 0.006 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.856103e-01 0.006 0 0
Fertilization R-HSA-1187000 9.856103e-01 0.006 0 0
Laminin interactions R-HSA-3000157 9.856103e-01 0.006 0 0
Mitochondrial protein import R-HSA-1268020 9.859943e-01 0.006 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.860659e-01 0.006 0 0
RAS processing R-HSA-9648002 9.865366e-01 0.006 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.865366e-01 0.006 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.870331e-01 0.006 0 0
Signaling by NOTCH4 R-HSA-9013694 9.870430e-01 0.006 0 0
MET activates PTK2 signaling R-HSA-8874081 9.874520e-01 0.005 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.874520e-01 0.005 0 0
Urea cycle R-HSA-70635 9.874520e-01 0.005 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.874520e-01 0.005 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 9.880404e-01 0.005 0 0
Tryptophan catabolism R-HSA-71240 9.880404e-01 0.005 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.882008e-01 0.005 0 0
SARS-CoV-2-host interactions R-HSA-9705683 9.883769e-01 0.005 0 0
Innate Immune System R-HSA-168249 9.886405e-01 0.005 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.890581e-01 0.005 0 0
Triglyceride biosynthesis R-HSA-75109 9.890581e-01 0.005 0 0
Synthesis of PE R-HSA-1483213 9.890581e-01 0.005 0 0
Signaling by BMP R-HSA-201451 9.890581e-01 0.005 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.893798e-01 0.005 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.893798e-01 0.005 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.893798e-01 0.005 0 0
Translation of Structural Proteins R-HSA-9694635 9.902289e-01 0.004 0 0
Prednisone ADME R-HSA-9757110 9.904587e-01 0.004 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.904587e-01 0.004 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.905724e-01 0.004 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.914413e-01 0.004 0 0
Paracetamol ADME R-HSA-9753281 9.915861e-01 0.004 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.916338e-01 0.004 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.916338e-01 0.004 0 0
Thyroxine biosynthesis R-HSA-209968 9.916800e-01 0.004 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.916800e-01 0.004 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.916800e-01 0.004 0 0
Glucagon-type ligand receptors R-HSA-420092 9.916800e-01 0.004 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.923325e-01 0.003 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.925781e-01 0.003 0 0
Defensins R-HSA-1461973 9.925781e-01 0.003 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.926006e-01 0.003 0 0
Peptide hormone metabolism R-HSA-2980736 9.927156e-01 0.003 0 0
Neurotransmitter clearance R-HSA-112311 9.927451e-01 0.003 0 0
ABC-family proteins mediated transport R-HSA-382556 9.932952e-01 0.003 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.934177e-01 0.003 0 0
Surfactant metabolism R-HSA-5683826 9.934177e-01 0.003 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.936739e-01 0.003 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.936739e-01 0.003 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 9.936739e-01 0.003 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.936739e-01 0.003 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.937492e-01 0.003 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.941641e-01 0.003 0 0
Somitogenesis R-HSA-9824272 9.941641e-01 0.003 0 0
Metabolism of cofactors R-HSA-8978934 9.943595e-01 0.002 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.944839e-01 0.002 0 0
Inositol phosphate metabolism R-HSA-1483249 9.945235e-01 0.002 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.949123e-01 0.002 0 0
Mitochondrial protein degradation R-HSA-9837999 9.953122e-01 0.002 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.956538e-01 0.002 0 0
Collagen degradation R-HSA-1442490 9.956538e-01 0.002 0 0
Nucleotide salvage R-HSA-8956321 9.956538e-01 0.002 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.958060e-01 0.002 0 0
tRNA processing in the nucleus R-HSA-6784531 9.961118e-01 0.002 0 0
Iron uptake and transport R-HSA-917937 9.962748e-01 0.002 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.962905e-01 0.002 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.963431e-01 0.002 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.963431e-01 0.002 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.963431e-01 0.002 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.963431e-01 0.002 0 0
Signal amplification R-HSA-392518 9.963431e-01 0.002 0 0
Signaling by NOTCH2 R-HSA-1980145 9.963431e-01 0.002 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.963431e-01 0.002 0 0
Gap junction assembly R-HSA-190861 9.963431e-01 0.002 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.963431e-01 0.002 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.965962e-01 0.001 0 0
Extracellular matrix organization R-HSA-1474244 9.965999e-01 0.001 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.966402e-01 0.001 0 0
Pyruvate metabolism R-HSA-70268 9.966402e-01 0.001 0 0
Selenoamino acid metabolism R-HSA-2408522 9.967676e-01 0.001 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.968114e-01 0.001 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.968114e-01 0.001 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.968114e-01 0.001 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.968114e-01 0.001 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.968114e-01 0.001 0 0
Neddylation R-HSA-8951664 9.968433e-01 0.001 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.968477e-01 0.001 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.970730e-01 0.001 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.971813e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.971813e-01 0.001 0 0
Cellular response to hypoxia R-HSA-1234174 9.972214e-01 0.001 0 0
ER-Phagosome pathway R-HSA-1236974 9.972467e-01 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 9.972812e-01 0.001 0 0
SLC transporter disorders R-HSA-5619102 9.974276e-01 0.001 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.975054e-01 0.001 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.975174e-01 0.001 0 0
Degradation of AXIN R-HSA-4641257 9.975758e-01 0.001 0 0
NCAM1 interactions R-HSA-419037 9.975758e-01 0.001 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.975758e-01 0.001 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.975758e-01 0.001 0 0
Lysine catabolism R-HSA-71064 9.975758e-01 0.001 0 0
Nicotinate metabolism R-HSA-196807 9.977826e-01 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 9.977928e-01 0.001 0 0
Purine salvage R-HSA-74217 9.978863e-01 0.001 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.979251e-01 0.001 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.981571e-01 0.001 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.981571e-01 0.001 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.981571e-01 0.001 0 0
Protein folding R-HSA-391251 9.981588e-01 0.001 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.983931e-01 0.001 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.983931e-01 0.001 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.984304e-01 0.001 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 9.984322e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.985927e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.985927e-01 0.001 0 0
Metabolism of porphyrins R-HSA-189445 9.985927e-01 0.001 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.985990e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.986501e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.986501e-01 0.001 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.987785e-01 0.001 0 0
Heme biosynthesis R-HSA-189451 9.987785e-01 0.001 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.988430e-01 0.001 0 0
Peroxisomal protein import R-HSA-9033241 9.989457e-01 0.000 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.989927e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.990022e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.990526e-01 0.000 1 0
tRNA Aminoacylation R-HSA-379724 9.990685e-01 0.000 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.990685e-01 0.000 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.990714e-01 0.000 0 0
Proteasome assembly R-HSA-9907900 9.991904e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.992519e-01 0.000 0 0
SARS-CoV Infections R-HSA-9679506 9.992641e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.993582e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.993598e-01 0.000 0 0
ABC transporter disorders R-HSA-5619084 9.993714e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.994493e-01 0.000 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.994635e-01 0.000 0 0
Synthesis of PC R-HSA-1483191 9.994635e-01 0.000 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.995167e-01 0.000 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.995322e-01 0.000 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.995922e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.995922e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.996104e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.996445e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.996563e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.996640e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.997223e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.997485e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.997485e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.997641e-01 0.000 0 0
Protein localization R-HSA-9609507 9.997818e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.997920e-01 0.000 0 0
PPARA activates gene expression R-HSA-1989781 9.998190e-01 0.000 0 0
Digestion R-HSA-8935690 9.998439e-01 0.000 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.998501e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.998575e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.998922e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.998990e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999025e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.999025e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.999099e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.999099e-01 0.000 0 0
Viral Infection Pathways R-HSA-9824446 9.999144e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999333e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999403e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.999479e-01 0.000 0 0
Glycosphingolipid biosynthesis R-HSA-9840309 9.999479e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999532e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999546e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.999566e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999632e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999633e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999655e-01 0.000 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.999698e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.999772e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999806e-01 0.000 0 0
RSV-host interactions R-HSA-9833110 9.999823e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999849e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999852e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999915e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999933e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999934e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999948e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999950e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999967e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999973e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999975e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999983e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999983e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999987e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999987e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999988e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999989e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999990e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999993e-01 0.000 0 0
tRNA processing R-HSA-72306 9.999994e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999994e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999994e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999995e-01 0.000 0 0
Translation R-HSA-72766 9.999995e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999997e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999998e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999999e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999999e-01 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Post-translational protein modification R-HSA-597592 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 1 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 0 0
M Phase R-HSA-68886 1.110223e-16 15.955 0 0
Cell Cycle, Mitotic R-HSA-69278 1.110223e-16 15.955 0 0
Cell Cycle Checkpoints R-HSA-69620 1.121325e-14 13.950 0 0
Cellular responses to stimuli R-HSA-8953897 8.596457e-13 12.066 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.014522e-12 11.994 0 0
Mitotic Prometaphase R-HSA-68877 2.560396e-12 11.592 0 0
Axon guidance R-HSA-422475 2.722600e-12 11.565 0 0
Cellular responses to stress R-HSA-2262752 2.553069e-12 11.593 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.713474e-12 11.430 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.953171e-12 11.403 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.953171e-12 11.403 0 0
HSF1-dependent transactivation R-HSA-3371571 4.991008e-12 11.302 0 0
Nervous system development R-HSA-9675108 7.909784e-12 11.102 0 0
Cellular response to heat stress R-HSA-3371556 1.359324e-11 10.867 0 0
Cell-Cell communication R-HSA-1500931 1.917799e-11 10.717 0 0
Attenuation phase R-HSA-3371568 2.144507e-11 10.669 0 0
Signaling by ROBO receptors R-HSA-376176 4.481737e-11 10.349 0 0
Ub-specific processing proteases R-HSA-5689880 9.152767e-11 10.038 0 0
Separation of Sister Chromatids R-HSA-2467813 1.131483e-10 9.946 0 0
Eukaryotic Translation Elongation R-HSA-156842 2.487224e-10 9.604 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.816364e-10 9.550 0 0
Mitotic Anaphase R-HSA-68882 4.588947e-10 9.338 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 5.372440e-10 9.270 0 0
HSF1 activation R-HSA-3371511 5.641156e-10 9.249 0 0
Formation of a pool of free 40S subunits R-HSA-72689 6.922714e-10 9.160 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 7.070549e-10 9.151 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 7.070549e-10 9.151 0 0
Deubiquitination R-HSA-5688426 6.960581e-10 9.157 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.134380e-09 8.945 0 0
Nucleosome assembly R-HSA-774815 1.279227e-09 8.893 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.279227e-09 8.893 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.457513e-09 8.836 0 0
HDACs deacetylate histones R-HSA-3214815 2.141191e-09 8.669 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.151086e-09 8.667 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 2.366930e-09 8.626 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.938603e-09 8.532 0 0
Peptide chain elongation R-HSA-156902 3.014786e-09 8.521 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 3.064767e-09 8.514 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 3.315924e-09 8.479 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.666616e-09 8.436 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 4.598795e-09 8.337 0 0
Cell junction organization R-HSA-446728 6.719689e-09 8.173 0 0
Apoptotic execution phase R-HSA-75153 8.310121e-09 8.080 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.221893e-08 7.913 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.451441e-08 7.838 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.506042e-08 7.822 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.683914e-08 7.774 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.683914e-08 7.774 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.646222e-08 7.784 0 0
G2/M Checkpoints R-HSA-69481 1.747588e-08 7.758 0 0
Meiotic synapsis R-HSA-1221632 1.946710e-08 7.711 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.009794e-08 7.697 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.159865e-08 7.666 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.220681e-08 7.654 0 0
Translation initiation complex formation R-HSA-72649 2.647779e-08 7.577 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.958818e-08 7.402 0 0
Cellular Senescence R-HSA-2559583 3.915849e-08 7.407 0 0
Assembly of the pre-replicative complex R-HSA-68867 4.105625e-08 7.387 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.804858e-08 7.318 0 0
Adherens junctions interactions R-HSA-418990 5.324360e-08 7.274 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 6.713769e-08 7.173 0 0
Ribosome-associated quality control R-HSA-9948299 6.533218e-08 7.185 0 0
DNA methylation R-HSA-5334118 7.163213e-08 7.145 0 0
Mitotic Spindle Checkpoint R-HSA-69618 7.313855e-08 7.136 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 7.756985e-08 7.110 0 0
Eukaryotic Translation Termination R-HSA-72764 7.855379e-08 7.105 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 8.509480e-08 7.070 0 0
G2/M Transition R-HSA-69275 9.483821e-08 7.023 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.108090e-07 6.955 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.108090e-07 6.955 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.261424e-07 6.899 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.472934e-07 6.832 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.596891e-07 6.797 0 0
Packaging Of Telomere Ends R-HSA-171306 1.596891e-07 6.797 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.636621e-07 6.786 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.797337e-07 6.745 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.881072e-07 6.726 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.975026e-07 6.704 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.348038e-07 6.629 0 0
Cell-cell junction organization R-HSA-421270 3.033988e-07 6.518 0 0
Metabolism of RNA R-HSA-8953854 3.108113e-07 6.508 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 3.515202e-07 6.454 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 3.399105e-07 6.469 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.653826e-07 6.437 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 4.077935e-07 6.390 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.491658e-07 6.348 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 6.879508e-07 6.162 0 0
Selenocysteine synthesis R-HSA-2408557 7.655627e-07 6.116 0 0
DNA Double Strand Break Response R-HSA-5693606 8.546795e-07 6.068 0 0
RNA Polymerase I Transcription R-HSA-73864 9.779431e-07 6.010 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.080138e-06 5.967 0 0
Viral mRNA Translation R-HSA-192823 1.105887e-06 5.956 0 0
Influenza Infection R-HSA-168255 1.112850e-06 5.954 0 0
Meiosis R-HSA-1500620 1.377636e-06 5.861 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.492859e-06 5.826 0 0
rRNA processing R-HSA-72312 1.500419e-06 5.824 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.637440e-06 5.786 0 0
Mitotic Prophase R-HSA-68875 1.753812e-06 5.756 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.768462e-06 5.752 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.939720e-06 5.712 0 0
Chromatin modifying enzymes R-HSA-3247509 1.882231e-06 5.725 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.968504e-06 5.706 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.979833e-06 5.703 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 2.008252e-06 5.697 0 0
Regulation of CDH1 Function R-HSA-9764561 2.975986e-06 5.526 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 3.015759e-06 5.521 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.901694e-06 5.537 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 2.936660e-06 5.532 0 0
Homology Directed Repair R-HSA-5693538 3.278028e-06 5.484 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 3.339016e-06 5.476 0 0
Defective pyroptosis R-HSA-9710421 3.636851e-06 5.439 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 3.791125e-06 5.421 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 4.480370e-06 5.349 0 0
Chromatin organization R-HSA-4839726 4.633733e-06 5.334 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 5.301406e-06 5.276 0 0
Interleukin-12 signaling R-HSA-9020591 5.983390e-06 5.223 0 0
Apoptosis R-HSA-109581 6.574699e-06 5.182 0 0
Regulation of endogenous retroelements R-HSA-9842860 6.838183e-06 5.165 0 0
Cleavage of the damaged purine R-HSA-110331 7.290353e-06 5.137 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 8.041008e-06 5.095 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 8.272540e-06 5.082 0 0
Meiotic recombination R-HSA-912446 8.030194e-06 5.095 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 7.995806e-06 5.097 0 0
Diseases of programmed cell death R-HSA-9645723 8.507972e-06 5.070 0 0
TCF dependent signaling in response to WNT R-HSA-201681 9.129221e-06 5.040 0 0
Depurination R-HSA-73927 9.694892e-06 5.013 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.019291e-05 4.992 0 0
DNA Replication R-HSA-69306 1.059510e-05 4.975 0 0
HATs acetylate histones R-HSA-3214847 1.095104e-05 4.961 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.188119e-05 4.925 0 0
Chromosome Maintenance R-HSA-73886 1.288290e-05 4.890 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.812450e-05 4.742 0 0
AURKA Activation by TPX2 R-HSA-8854518 2.135576e-05 4.670 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.171562e-05 4.663 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 2.171562e-05 4.663 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 2.651762e-05 4.576 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 2.746668e-05 4.561 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 2.761626e-05 4.559 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 3.318897e-05 4.479 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 3.491609e-05 4.457 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 3.491609e-05 4.457 0 0
Developmental Biology R-HSA-1266738 3.560361e-05 4.449 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 3.581642e-05 4.446 0 0
Depyrimidination R-HSA-73928 3.581642e-05 4.446 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.806579e-05 4.419 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 4.053226e-05 4.392 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 4.405229e-05 4.356 0 0
Signaling by ALK in cancer R-HSA-9700206 4.405229e-05 4.356 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 4.513557e-05 4.345 0 0
p75NTR signals via NF-kB R-HSA-193639 4.570245e-05 4.340 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 4.612068e-05 4.336 0 0
Metalloprotease DUBs R-HSA-5689901 5.070849e-05 4.295 0 0
Interleukin-12 family signaling R-HSA-447115 5.179257e-05 4.286 0 0
Signal Transduction R-HSA-162582 5.774290e-05 4.239 1 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 5.804413e-05 4.236 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 7.052464e-05 4.152 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 7.867282e-05 4.104 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 8.950411e-05 4.048 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 9.020946e-05 4.045 1 1
Cellular response to starvation R-HSA-9711097 9.138239e-05 4.039 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 9.704762e-05 4.013 1 1
Programmed Cell Death R-HSA-5357801 1.061654e-04 3.974 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.084761e-04 3.965 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.085750e-04 3.964 0 0
Protein ubiquitination R-HSA-8852135 1.106787e-04 3.956 0 0
Centrosome maturation R-HSA-380287 1.106787e-04 3.956 0 0
Late endosomal microautophagy R-HSA-9615710 1.221766e-04 3.913 0 0
Signaling by WNT R-HSA-195721 1.125263e-04 3.949 0 0
Death Receptor Signaling R-HSA-73887 1.226431e-04 3.911 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.243505e-04 3.905 0 0
UCH proteinases R-HSA-5689603 1.306494e-04 3.884 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.348957e-04 3.870 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.425681e-04 3.846 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.706936e-04 3.768 0 0
Aggrephagy R-HSA-9646399 1.968951e-04 3.706 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.009947e-04 3.697 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.064244e-04 3.685 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.096417e-04 3.679 0 0
Co-inhibition by PD-1 R-HSA-389948 2.239362e-04 3.650 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.343651e-04 3.630 0 0
NF-kB is activated and signals survival R-HSA-209560 2.360240e-04 3.627 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.490872e-04 3.604 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 2.599137e-04 3.585 0 0
Post NMDA receptor activation events R-HSA-438064 3.249221e-04 3.488 1 0
Signaling by NOTCH R-HSA-157118 3.585508e-04 3.445 0 0
p75NTR recruits signalling complexes R-HSA-209543 3.610200e-04 3.442 0 0
Kinesins R-HSA-983189 4.517968e-04 3.345 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.501872e-04 3.347 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 4.359774e-04 3.361 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 4.592680e-04 3.338 0 0
Degradation of CDH1 R-HSA-9766229 4.948625e-04 3.306 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 5.021284e-04 3.299 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 5.102898e-04 3.292 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 5.344331e-04 3.272 0 0
Switching of origins to a post-replicative state R-HSA-69052 5.344331e-04 3.272 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 5.405715e-04 3.267 0 0
Josephin domain DUBs R-HSA-5689877 5.405715e-04 3.267 0 0
RMTs methylate histone arginines R-HSA-3214858 5.561285e-04 3.255 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 5.672611e-04 3.246 0 0
Membrane Trafficking R-HSA-199991 5.805150e-04 3.236 0 0
Viral Infection Pathways R-HSA-9824446 5.916729e-04 3.228 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 6.169891e-04 3.210 0 0
Signaling by VEGF R-HSA-194138 6.211498e-04 3.207 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 6.278020e-04 3.202 0 0
Translation R-HSA-72766 6.753429e-04 3.170 0 0
Telomere Maintenance R-HSA-157579 6.918379e-04 3.160 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 7.281238e-04 3.138 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 8.301492e-04 3.081 0 0
Orc1 removal from chromatin R-HSA-68949 8.436138e-04 3.074 0 0
Regulation of PTEN localization R-HSA-8948747 7.686303e-04 3.114 0 0
Selective autophagy R-HSA-9663891 8.736743e-04 3.059 0 0
G0 and Early G1 R-HSA-1538133 8.991767e-04 3.046 0 0
Recycling pathway of L1 R-HSA-437239 9.689433e-04 3.014 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 9.807461e-04 3.008 0 0
HCMV Early Events R-HSA-9609690 1.017440e-03 2.992 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.019872e-03 2.991 0 0
DNA Repair R-HSA-73894 1.046460e-03 2.980 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.061346e-03 2.974 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.091628e-03 2.962 0 0
Base Excision Repair R-HSA-73884 1.127290e-03 2.948 0 0
Gene Silencing by RNA R-HSA-211000 1.171322e-03 2.931 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.178807e-03 2.929 0 0
Autophagy R-HSA-9612973 1.185387e-03 2.926 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.236028e-03 2.908 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.246944e-03 2.904 0 0
G1/S Transition R-HSA-69206 1.269331e-03 2.896 0 0
Selenoamino acid metabolism R-HSA-2408522 1.288960e-03 2.890 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.368594e-03 2.864 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.498977e-03 2.824 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.517277e-03 2.819 0 0
Amyloid fiber formation R-HSA-977225 1.622128e-03 2.790 0 0
TCR signaling R-HSA-202403 1.629414e-03 2.788 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.705780e-03 2.768 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.755011e-03 2.756 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.767391e-03 2.753 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.767391e-03 2.753 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.167727e-03 2.664 0 0
S Phase R-HSA-69242 2.058815e-03 2.686 0 0
Muscle contraction R-HSA-397014 2.166154e-03 2.664 0 0
Host Interactions of HIV factors R-HSA-162909 2.068662e-03 2.684 0 0
Reproduction R-HSA-1474165 2.286000e-03 2.641 0 0
EGFR downregulation R-HSA-182971 2.292975e-03 2.640 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 2.470930e-03 2.607 0 0
Calmodulin induced events R-HSA-111933 2.479904e-03 2.606 1 0
CaM pathway R-HSA-111997 2.479904e-03 2.606 1 0
G alpha (12/13) signalling events R-HSA-416482 2.509583e-03 2.600 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.645299e-03 2.578 1 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.656913e-03 2.576 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.745320e-03 2.561 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 2.850736e-03 2.545 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.870600e-03 2.542 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.903442e-03 2.537 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.912766e-03 2.536 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.912766e-03 2.536 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.912766e-03 2.536 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.912766e-03 2.536 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.912766e-03 2.536 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 3.004472e-03 2.522 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.109673e-03 2.507 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 3.372287e-03 2.472 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.397801e-03 2.469 0 0
Signaling by NOTCH4 R-HSA-9013694 3.421584e-03 2.466 0 0
L1CAM interactions R-HSA-373760 3.662032e-03 2.436 0 0
HIV Infection R-HSA-162906 3.677293e-03 2.434 0 0
HCMV Infection R-HSA-9609646 3.726964e-03 2.429 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 4.515235e-03 2.345 0 0
Spry regulation of FGF signaling R-HSA-1295596 4.504706e-03 2.346 0 0
Regulation of signaling by CBL R-HSA-912631 4.479054e-03 2.349 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 4.091355e-03 2.388 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.123467e-03 2.385 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 4.054866e-03 2.392 0 0
Signaling by EGFR R-HSA-177929 4.002205e-03 2.398 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 4.479054e-03 2.349 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.668099e-03 2.331 0 0
HIV Life Cycle R-HSA-162587 4.382010e-03 2.358 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 4.782712e-03 2.320 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 4.668099e-03 2.331 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 4.504706e-03 2.346 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 4.369336e-03 2.360 0 0
ESR-mediated signaling R-HSA-8939211 4.310754e-03 2.365 0 0
DAG and IP3 signaling R-HSA-1489509 4.914866e-03 2.308 1 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 5.212712e-03 2.283 0 0
Deadenylation of mRNA R-HSA-429947 5.212712e-03 2.283 0 0
Signaling by Interleukins R-HSA-449147 5.227649e-03 2.282 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.270252e-03 2.278 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.270252e-03 2.278 0 0
Intracellular signaling by second messengers R-HSA-9006925 5.381610e-03 2.269 1 0
Activation of RAC1 R-HSA-428540 5.649445e-03 2.248 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.649445e-03 2.248 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.649445e-03 2.248 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 5.649445e-03 2.248 0 0
Nephrin family interactions R-HSA-373753 5.674363e-03 2.246 0 0
Negative regulation of MET activity R-HSA-6807004 5.674363e-03 2.246 0 0
mRNA Splicing R-HSA-72172 5.995513e-03 2.222 0 0
Cilium Assembly R-HSA-5617833 6.039461e-03 2.219 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 6.847304e-03 2.164 1 1
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 6.679355e-03 2.175 1 1
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 7.627741e-03 2.118 1 0
Pervasive developmental disorders R-HSA-9005895 7.627741e-03 2.118 1 0
Disorders of Nervous System Development R-HSA-9697154 7.627741e-03 2.118 1 0
IRAK1 recruits IKK complex R-HSA-937039 7.627741e-03 2.118 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 7.627741e-03 2.118 0 0
Disorders of Developmental Biology R-HSA-9675151 7.601607e-03 2.119 1 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 7.098248e-03 2.149 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 7.098248e-03 2.149 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 7.098248e-03 2.149 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 6.759458e-03 2.170 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 6.759458e-03 2.170 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 6.793810e-03 2.168 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 6.793810e-03 2.168 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 6.318775e-03 2.199 0 0
Regulation of TP53 Degradation R-HSA-6804757 6.867429e-03 2.163 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 6.793810e-03 2.168 0 0
Late Phase of HIV Life Cycle R-HSA-162599 7.585675e-03 2.120 0 0
Activation of HOX genes during differentiation R-HSA-5619507 7.119734e-03 2.148 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 7.119734e-03 2.148 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 7.810421e-03 2.107 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 7.131297e-03 2.147 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 6.875916e-03 2.163 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 7.131297e-03 2.147 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 7.131297e-03 2.147 0 0
EPH-Ephrin signaling R-HSA-2682334 7.099920e-03 2.149 0 0
MAP kinase activation R-HSA-450294 7.711849e-03 2.113 0 0
HCMV Late Events R-HSA-9610379 7.708041e-03 2.113 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 6.759458e-03 2.170 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 7.222481e-03 2.141 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 6.679355e-03 2.175 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 6.793810e-03 2.168 0 0
Ca-dependent events R-HSA-111996 7.889285e-03 2.103 1 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 8.052669e-03 2.094 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 8.080169e-03 2.093 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 8.226099e-03 2.085 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 8.451013e-03 2.073 0 0
Hedgehog 'off' state R-HSA-5610787 8.621720e-03 2.064 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 8.706045e-03 2.060 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 8.706045e-03 2.060 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.708748e-03 2.060 0 0
Assembly Of The HIV Virion R-HSA-175474 8.776265e-03 2.057 0 0
Cytokine Signaling in Immune system R-HSA-1280215 8.819408e-03 2.055 0 0
Signaling by NOTCH1 R-HSA-1980143 9.301143e-03 2.031 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 9.336966e-03 2.030 0 0
NRAGE signals death through JNK R-HSA-193648 9.336966e-03 2.030 0 0
Synthesis of DNA R-HSA-69239 9.355731e-03 2.029 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 9.481586e-03 2.023 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 9.481586e-03 2.023 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 9.528237e-03 2.021 0 0
Regulation of TP53 Activity R-HSA-5633007 9.582830e-03 2.019 0 0
Signaling by Hippo R-HSA-2028269 9.636881e-03 2.016 0 0
Semaphorin interactions R-HSA-373755 9.805217e-03 2.009 0 0
PTEN Regulation R-HSA-6807070 9.835924e-03 2.007 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.013399e-02 1.994 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.013399e-02 1.994 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 1.021631e-02 1.991 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.032161e-02 1.986 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 1.049162e-02 1.979 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.056258e-02 1.976 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 1.073416e-02 1.969 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 1.073416e-02 1.969 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.076499e-02 1.968 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 1.076499e-02 1.968 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.076499e-02 1.968 0 0
Maturation of protein E R-HSA-9694493 1.076499e-02 1.968 0 0
Maturation of protein E R-HSA-9683683 1.076499e-02 1.968 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 1.092266e-02 1.962 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.093543e-02 1.961 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 1.113959e-02 1.953 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 1.118515e-02 1.951 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.120168e-02 1.951 0 0
Striated Muscle Contraction R-HSA-390522 1.120168e-02 1.951 0 0
Macroautophagy R-HSA-1632852 1.142920e-02 1.942 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 1.145765e-02 1.941 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.153866e-02 1.938 1 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.153866e-02 1.938 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.167987e-02 1.933 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 1.520461e-02 1.818 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.371230e-02 1.863 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 1.282251e-02 1.892 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.448427e-02 1.839 0 0
Neutrophil degranulation R-HSA-6798695 1.283108e-02 1.892 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.538567e-02 1.813 0 0
Protein folding R-HSA-391251 1.389394e-02 1.857 0 0
Signaling by ERBB2 R-HSA-1227986 1.500461e-02 1.824 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.300256e-02 1.886 0 0
Regulation of Apoptosis R-HSA-169911 1.520461e-02 1.818 0 0
Opioid Signalling R-HSA-111885 1.235778e-02 1.908 1 0
Signaling by NOTCH2 R-HSA-1980145 1.308861e-02 1.883 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.212869e-02 1.916 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.212869e-02 1.916 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 1.558107e-02 1.807 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.201937e-02 1.920 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.201937e-02 1.920 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.300256e-02 1.886 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.453131e-02 1.838 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.500461e-02 1.824 0 0
Signal regulatory protein family interactions R-HSA-391160 1.300256e-02 1.886 0 0
Pexophagy R-HSA-9664873 1.300200e-02 1.886 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 1.263650e-02 1.898 0 0
Neurodegenerative Diseases R-HSA-8863678 1.559168e-02 1.807 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.559168e-02 1.807 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.300200e-02 1.886 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.258051e-02 1.900 0 0
PKR-mediated signaling R-HSA-9833482 1.404161e-02 1.853 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.589628e-02 1.799 0 0
CREB phosphorylation R-HSA-199920 1.589628e-02 1.799 0 0
Glycolysis R-HSA-70171 1.629540e-02 1.788 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.644175e-02 1.784 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.649751e-02 1.783 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.649751e-02 1.783 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.649751e-02 1.783 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 1.649751e-02 1.783 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.663256e-02 1.779 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.678144e-02 1.775 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.731287e-02 1.762 0 0
RET signaling R-HSA-8853659 1.756511e-02 1.755 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 1.756511e-02 1.755 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.794625e-02 1.746 0 0
Budding and maturation of HIV virion R-HSA-162588 1.826254e-02 1.738 0 0
tRNA processing in the nucleus R-HSA-6784531 1.868148e-02 1.729 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.872731e-02 1.728 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.895288e-02 1.722 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.927326e-02 1.715 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 2.018526e-02 1.695 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.018526e-02 1.695 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.018526e-02 1.695 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 2.042821e-02 1.690 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 2.042821e-02 1.690 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.046489e-02 1.689 0 0
TNF signaling R-HSA-75893 2.046489e-02 1.689 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 2.059103e-02 1.686 0 0
Negative regulation of FLT3 R-HSA-9706369 2.059103e-02 1.686 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 2.075796e-02 1.683 0 0
Interleukin-17 signaling R-HSA-448424 2.082884e-02 1.681 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 2.182914e-02 1.661 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.186908e-02 1.660 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.234318e-02 1.651 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.234318e-02 1.651 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 2.300342e-02 1.638 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.307982e-02 1.637 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.429991e-02 1.614 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.450517e-02 1.611 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.017765e-02 1.520 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.854685e-02 1.544 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 2.532299e-02 1.596 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 2.532299e-02 1.596 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 2.604903e-02 1.584 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 3.433985e-02 1.464 0 0
Dual Incision in GG-NER R-HSA-5696400 3.213126e-02 1.493 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 2.735043e-02 1.563 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 3.066740e-02 1.513 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 3.066740e-02 1.513 0 0
Signaling downstream of RAS mutants R-HSA-9649948 3.066740e-02 1.513 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 3.426152e-02 1.465 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.542542e-02 1.595 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.771972e-02 1.557 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.246237e-02 1.489 0 0
Generation of second messenger molecules R-HSA-202433 2.974838e-02 1.527 0 0
mTORC1-mediated signalling R-HSA-166208 3.079360e-02 1.512 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 2.532299e-02 1.596 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 3.683620e-02 1.434 0 0
Ephrin signaling R-HSA-3928664 3.683620e-02 1.434 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 2.532299e-02 1.596 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 2.735043e-02 1.563 0 0
Signaling by RAS mutants R-HSA-6802949 3.066740e-02 1.513 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.604903e-02 1.584 1 1
Asymmetric localization of PCP proteins R-HSA-4608870 2.735043e-02 1.563 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.066740e-02 1.513 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.433985e-02 1.464 0 0
PLC beta mediated events R-HSA-112043 3.427912e-02 1.465 1 0
Neurexins and neuroligins R-HSA-6794361 2.792986e-02 1.554 0 0
Interleukin-1 signaling R-HSA-9020702 3.181196e-02 1.497 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 3.650207e-02 1.438 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 3.354879e-02 1.474 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 3.354879e-02 1.474 0 0
Stabilization of p53 R-HSA-69541 2.626300e-02 1.581 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 2.626300e-02 1.581 0 0
Mitophagy R-HSA-5205647 3.213126e-02 1.493 0 0
Circadian clock R-HSA-9909396 2.780324e-02 1.556 0 0
NOD1/2 Signaling Pathway R-HSA-168638 3.213126e-02 1.493 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.780324e-02 1.556 0 0
Regulation of PTEN stability and activity R-HSA-8948751 3.107136e-02 1.508 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.880273e-02 1.541 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 3.017765e-02 1.520 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 2.854685e-02 1.544 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 2.854685e-02 1.544 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 3.072826e-02 1.512 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 3.683620e-02 1.434 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.626300e-02 1.581 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.974838e-02 1.527 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 2.974838e-02 1.527 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.974838e-02 1.527 0 0
Smooth Muscle Contraction R-HSA-445355 3.107136e-02 1.508 0 0
Nuclear import of Rev protein R-HSA-180746 3.213126e-02 1.493 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.017765e-02 1.520 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.017765e-02 1.520 0 0
Vpu mediated degradation of CD4 R-HSA-180534 2.813720e-02 1.551 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 3.213126e-02 1.493 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 3.213126e-02 1.493 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.665102e-02 1.574 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.559808e-02 1.592 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 3.683620e-02 1.434 0 0
FLT3 Signaling R-HSA-9607240 3.354879e-02 1.474 0 0
Transport of connexons to the plasma membrane R-HSA-190872 3.683620e-02 1.434 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.608591e-02 1.443 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.683620e-02 1.434 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 3.683620e-02 1.434 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 2.604903e-02 1.584 0 0
Modulation by Mtb of host immune system R-HSA-9637628 3.017765e-02 1.520 0 0
Signaling by RAF1 mutants R-HSA-9656223 3.767616e-02 1.424 0 0
Degradation of CRY and PER proteins R-HSA-9932298 3.767616e-02 1.424 0 0
Signaling by NOTCH3 R-HSA-9012852 3.810112e-02 1.419 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.814282e-02 1.419 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 3.899426e-02 1.409 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.938852e-02 1.405 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.960037e-02 1.402 0 0
Manipulation of host energy metabolism R-HSA-9636667 4.049233e-02 1.393 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.049233e-02 1.393 0 0
FLT3 signaling in disease R-HSA-9682385 4.126296e-02 1.384 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 4.128991e-02 1.384 0 0
Interleukin-1 family signaling R-HSA-446652 4.130466e-02 1.384 0 0
Protein-protein interactions at synapses R-HSA-6794362 4.133201e-02 1.384 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.134312e-02 1.384 0 0
Signaling by PTK6 R-HSA-8848021 4.134312e-02 1.384 0 0
Glucose metabolism R-HSA-70326 4.148565e-02 1.382 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 4.194572e-02 1.377 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 4.194572e-02 1.377 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.194572e-02 1.377 0 0
Ion homeostasis R-HSA-5578775 4.200614e-02 1.377 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.214150e-02 1.375 0 0
DNA Damage Bypass R-HSA-73893 4.232064e-02 1.373 0 0
Signaling by Hedgehog R-HSA-5358351 4.316804e-02 1.365 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 4.355539e-02 1.361 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 4.355539e-02 1.361 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 4.367030e-02 1.360 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 4.367030e-02 1.360 0 0
Translesion Synthesis by POLH R-HSA-110320 4.367030e-02 1.360 0 0
Rap1 signalling R-HSA-392517 4.367030e-02 1.360 0 0
Trafficking of AMPA receptors R-HSA-399719 4.490950e-02 1.348 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 4.490950e-02 1.348 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 4.490950e-02 1.348 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.642580e-02 1.333 0 0
Degradation of DVL R-HSA-4641258 4.642580e-02 1.333 0 0
Degradation of AXIN R-HSA-4641257 4.642580e-02 1.333 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 4.695474e-02 1.328 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 4.695474e-02 1.328 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.718644e-02 1.326 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.718644e-02 1.326 0 0
Interferon Signaling R-HSA-913531 4.810715e-02 1.318 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 5.015203e-02 1.300 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 5.015203e-02 1.300 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 5.015203e-02 1.300 0 0
Regulation of CDH11 function R-HSA-9762292 5.015203e-02 1.300 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 5.124792e-02 1.290 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 5.124792e-02 1.290 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 5.141345e-02 1.289 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.152076e-02 1.288 0 0
Hedgehog ligand biogenesis R-HSA-5358346 5.159924e-02 1.287 0 0
Translesion synthesis by REV1 R-HSA-110312 5.254090e-02 1.280 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 5.254090e-02 1.280 0 0
Protein methylation R-HSA-8876725 5.254090e-02 1.280 0 0
DCC mediated attractive signaling R-HSA-418885 5.254090e-02 1.280 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.361833e-02 1.271 0 0
Organelle biogenesis and maintenance R-HSA-1852241 5.465804e-02 1.262 1 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 5.486755e-02 1.261 1 0
PIP3 activates AKT signaling R-HSA-1257604 5.503131e-02 1.259 0 0
snRNP Assembly R-HSA-191859 5.537011e-02 1.257 0 0
Metabolism of non-coding RNA R-HSA-194441 5.537011e-02 1.257 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 5.542914e-02 1.256 0 0
mRNA 3'-end processing R-HSA-72187 5.671458e-02 1.246 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.671458e-02 1.246 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 5.741604e-02 1.241 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 5.741604e-02 1.241 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 5.741604e-02 1.241 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 5.741604e-02 1.241 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 5.741604e-02 1.241 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 5.765890e-02 1.239 0 0
G-protein mediated events R-HSA-112040 5.841607e-02 1.233 1 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 5.958021e-02 1.225 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 5.958021e-02 1.225 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 6.064664e-02 1.217 0 0
Clathrin-mediated endocytosis R-HSA-8856828 6.066002e-02 1.217 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 6.086018e-02 1.216 0 0
Translesion synthesis by POLI R-HSA-5656121 6.252572e-02 1.204 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.252572e-02 1.204 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 6.307409e-02 1.200 0 0
Interaction between L1 and Ankyrins R-HSA-445095 6.307409e-02 1.200 0 0
Downstream TCR signaling R-HSA-202424 6.432683e-02 1.192 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 6.441931e-02 1.191 0 0
Glycogen metabolism R-HSA-8982491 6.442044e-02 1.191 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 6.571375e-02 1.182 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 6.726072e-02 1.172 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 6.726072e-02 1.172 0 0
Regulation of cortical dendrite branching R-HSA-8985801 6.726072e-02 1.172 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 6.726072e-02 1.172 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 6.726072e-02 1.172 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 6.726072e-02 1.172 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 6.726072e-02 1.172 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 6.726072e-02 1.172 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 6.726072e-02 1.172 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 6.726072e-02 1.172 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 6.726072e-02 1.172 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 6.726072e-02 1.172 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 6.726072e-02 1.172 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 6.867209e-02 1.163 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 6.867209e-02 1.163 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 6.867209e-02 1.163 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 6.867209e-02 1.163 0 0
Nef and signal transduction R-HSA-164944 7.082320e-02 1.150 0 0
Gene expression (Transcription) R-HSA-74160 7.103021e-02 1.149 1 0
PKMTs methylate histone lysines R-HSA-3214841 7.127685e-02 1.147 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 7.127685e-02 1.147 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 7.132906e-02 1.147 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 7.132906e-02 1.147 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 7.132906e-02 1.147 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 7.155402e-02 1.145 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 7.155402e-02 1.145 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 7.155402e-02 1.145 0 0
RAF activation R-HSA-5673000 7.193013e-02 1.143 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 7.193013e-02 1.143 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 7.350477e-02 1.134 0 0
Translesion synthesis by POLK R-HSA-5655862 7.350477e-02 1.134 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 7.350477e-02 1.134 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 7.350477e-02 1.134 0 0
Vesicle-mediated transport R-HSA-5653656 7.514076e-02 1.124 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 7.548191e-02 1.122 0 0
Signaling by GSK3beta mutants R-HSA-5339716 7.584243e-02 1.120 0 0
Integration of provirus R-HSA-162592 7.584243e-02 1.120 0 0
Notch-HLH transcription pathway R-HSA-350054 7.852238e-02 1.105 0 0
Hedgehog 'on' state R-HSA-5632684 7.968833e-02 1.099 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 7.995095e-02 1.097 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 7.995095e-02 1.097 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 7.995095e-02 1.097 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 7.998262e-02 1.097 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.019515e-02 1.096 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 8.019515e-02 1.096 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 8.019515e-02 1.096 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 8.019515e-02 1.096 0 0
SARS-CoV Infections R-HSA-9679506 8.026832e-02 1.095 0 0
Gap junction trafficking and regulation R-HSA-157858 8.354505e-02 1.078 0 0
Adaptive Immune System R-HSA-1280218 8.479844e-02 1.072 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.546261e-02 1.068 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 8.629893e-02 1.064 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 8.629893e-02 1.064 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 8.729486e-02 1.059 0 0
Signaling by MET R-HSA-6806834 8.729486e-02 1.059 0 0
Activation of the pre-replicative complex R-HSA-68962 8.966965e-02 1.047 0 0
Interleukin-37 signaling R-HSA-9008059 8.966965e-02 1.047 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 9.016944e-02 1.045 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 9.016944e-02 1.045 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 9.016944e-02 1.045 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 9.073743e-02 1.042 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 9.073743e-02 1.042 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 9.073743e-02 1.042 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 9.073743e-02 1.042 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 9.073743e-02 1.042 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 9.073743e-02 1.042 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 9.073743e-02 1.042 0 0
VLDLR internalisation and degradation R-HSA-8866427 9.073743e-02 1.042 0 0
MHC class II antigen presentation R-HSA-2132295 9.407055e-02 1.027 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 9.480075e-02 1.023 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 9.751934e-02 1.011 0 0
Signaling by ERBB4 R-HSA-1236394 9.851779e-02 1.006 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.974618e-02 1.001 0 0
Defective SFTPA2 causes IPF R-HSA-5687868 9.991237e-02 1.000 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 9.991237e-02 1.000 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.018369e-01 0.992 0 0
Gap junction trafficking R-HSA-190828 1.030663e-01 0.987 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.898476e-01 0.722 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.898476e-01 0.722 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.898476e-01 0.722 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.898476e-01 0.722 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.898476e-01 0.722 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.898476e-01 0.722 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.898476e-01 0.722 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.898476e-01 0.722 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.898476e-01 0.722 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.898476e-01 0.722 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.323757e-01 0.878 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.323757e-01 0.878 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.323757e-01 0.878 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 1.323757e-01 0.878 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 1.686792e-01 0.773 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.686792e-01 0.773 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.686792e-01 0.773 0 0
G2 Phase R-HSA-68911 1.686792e-01 0.773 0 0
RSK activation R-HSA-444257 1.114445e-01 0.953 0 0
Formation of annular gap junctions R-HSA-196025 1.114445e-01 0.953 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 1.344182e-01 0.872 0 0
ARMS-mediated activation R-HSA-170984 1.344182e-01 0.872 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.344182e-01 0.872 0 0
Gap junction degradation R-HSA-190873 1.344182e-01 0.872 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.063925e-01 0.685 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.063925e-01 0.685 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 2.063925e-01 0.685 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 2.063925e-01 0.685 0 0
2-LTR circle formation R-HSA-164843 1.588525e-01 0.799 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.588525e-01 0.799 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.242838e-01 0.906 0 0
Signaling by APC mutants R-HSA-4839744 1.845086e-01 0.734 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.845086e-01 0.734 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.845086e-01 0.734 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.845086e-01 0.734 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.427588e-01 0.845 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.427588e-01 0.845 0 0
G beta:gamma signalling through BTK R-HSA-8964315 1.427588e-01 0.845 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.252820e-01 0.902 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 1.387092e-01 0.858 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.037604e-01 0.691 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.037604e-01 0.691 0 0
FGFR2 alternative splicing R-HSA-6803529 1.758056e-01 0.755 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.177661e-01 0.929 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.826745e-01 0.738 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.129701e-01 0.947 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.826061e-01 0.738 0 0
G-protein beta:gamma signalling R-HSA-397795 1.216620e-01 0.915 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 1.458233e-01 0.836 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.385995e-01 0.858 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 2.000466e-01 0.699 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.276102e-01 0.894 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.200198e-01 0.921 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.216620e-01 0.915 0 0
G-protein activation R-HSA-202040 1.424556e-01 0.846 0 0
MAP2K and MAPK activation R-HSA-5674135 1.500459e-01 0.824 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 2.037604e-01 0.691 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.069592e-01 0.971 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 1.920375e-01 0.717 0 0
Developmental Cell Lineages R-HSA-9734767 1.098214e-01 0.959 0 0
MTOR signalling R-HSA-165159 1.619330e-01 0.791 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 1.934945e-01 0.713 0 0
Prolonged ERK activation events R-HSA-169893 1.622353e-01 0.790 0 0
Cellular response to chemical stress R-HSA-9711123 1.298285e-01 0.887 0 0
Long-term potentiation R-HSA-9620244 1.125243e-01 0.949 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.252820e-01 0.902 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 1.490751e-01 0.827 0 0
Calcineurin activates NFAT R-HSA-2025928 1.344182e-01 0.872 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 2.063925e-01 0.685 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.063925e-01 0.685 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 1.334714e-01 0.875 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.039558e-01 0.983 0 0
Toll-like Receptor Cascades R-HSA-168898 1.719758e-01 0.765 0 0
Regulation of KIT signaling R-HSA-1433559 1.242838e-01 0.906 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 2.063925e-01 0.685 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.069122e-01 0.971 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 2.000466e-01 0.699 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.650402e-01 0.782 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.427588e-01 0.845 0 0
ERK/MAPK targets R-HSA-198753 1.424556e-01 0.846 0 0
ER-Phagosome pathway R-HSA-1236974 1.589538e-01 0.799 0 0
Rab regulation of trafficking R-HSA-9007101 1.572133e-01 0.804 0 0
RNA Polymerase II Transcription R-HSA-73857 1.534631e-01 0.814 1 0
Signaling by FGFR2 R-HSA-5654738 1.435899e-01 0.843 0 0
Generic Transcription Pathway R-HSA-212436 1.850687e-01 0.733 1 0
Formation of editosomes by ADAR proteins R-HSA-77042 1.898476e-01 0.722 0 0
MTF1 activates gene expression R-HSA-5660489 1.323757e-01 0.878 0 0
Unwinding of DNA R-HSA-176974 1.344182e-01 0.872 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 2.063925e-01 0.685 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.458233e-01 0.836 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 2.000466e-01 0.699 0 0
Signaling by FGFR4 R-HSA-5654743 1.742424e-01 0.759 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 1.252820e-01 0.902 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.216620e-01 0.915 0 0
MAPK family signaling cascades R-HSA-5683057 1.328276e-01 0.877 0 0
Co-stimulation by CD28 R-HSA-389356 1.417025e-01 0.849 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.625047e-01 0.789 0 0
Signaling by FGFR3 R-HSA-5654741 2.000466e-01 0.699 0 0
The NLRP3 inflammasome R-HSA-844456 1.122056e-01 0.950 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.355029e-01 0.868 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.344182e-01 0.872 0 0
Somitogenesis R-HSA-9824272 2.000466e-01 0.699 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 1.984299e-01 0.702 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 2.001733e-01 0.699 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.355029e-01 0.868 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.427588e-01 0.845 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.215525e-01 0.915 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.634344e-01 0.787 0 0
ABC transporter disorders R-HSA-5619084 2.015875e-01 0.696 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.287110e-01 0.890 0 0
ABC-family proteins mediated transport R-HSA-382556 1.994675e-01 0.700 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.063925e-01 0.685 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 1.748613e-01 0.757 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.145336e-01 0.941 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.018622e-01 0.695 0 0
PCP/CE pathway R-HSA-4086400 1.274844e-01 0.895 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.216620e-01 0.915 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.836194e-01 0.736 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.266553e-01 0.897 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 1.424556e-01 0.846 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 1.344182e-01 0.872 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.385995e-01 0.858 0 0
G1/S-Specific Transcription R-HSA-69205 1.720627e-01 0.764 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.845086e-01 0.734 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.686792e-01 0.773 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.405337e-01 0.852 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.587718e-01 0.799 0 0
Regulation of BACH1 activity R-HSA-9708530 1.622353e-01 0.790 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.434106e-01 0.843 0 0
Glycogen storage diseases R-HSA-3229121 2.037604e-01 0.691 0 0
Infectious disease R-HSA-5663205 2.075846e-01 0.683 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.111525e-01 0.675 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.111525e-01 0.675 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.111525e-01 0.675 0 0
Signaling by AXIN mutants R-HSA-4839735 2.111525e-01 0.675 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.117733e-01 0.674 0 0
Regulation of pyruvate metabolism R-HSA-9861718 2.134970e-01 0.671 0 0
Cardiac conduction R-HSA-5576891 2.145763e-01 0.668 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.146654e-01 0.668 0 0
Pyruvate metabolism R-HSA-70268 2.179446e-01 0.662 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.255860e-01 0.647 0 0
GAB1 signalosome R-HSA-180292 2.255860e-01 0.647 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 2.255860e-01 0.647 0 0
Polo-like kinase mediated events R-HSA-156711 2.255860e-01 0.647 0 0
Mismatch Repair R-HSA-5358508 2.255860e-01 0.647 0 0
Presynaptic function of Kainate receptors R-HSA-500657 2.255860e-01 0.647 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.272812e-01 0.643 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 2.272812e-01 0.643 0 0
Immune System R-HSA-168256 2.291989e-01 0.640 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 2.299168e-01 0.638 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 2.299168e-01 0.638 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 2.299168e-01 0.638 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.305750e-01 0.637 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.305750e-01 0.637 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 2.305750e-01 0.637 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 2.310825e-01 0.636 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.313360e-01 0.636 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 2.369591e-01 0.625 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 2.373396e-01 0.625 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.385595e-01 0.622 0 0
Repression of WNT target genes R-HSA-4641265 2.385595e-01 0.622 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.385595e-01 0.622 0 0
Ca2+ pathway R-HSA-4086398 2.391075e-01 0.621 0 0
Gluconeogenesis R-HSA-70263 2.413742e-01 0.617 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.433250e-01 0.614 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.448720e-01 0.611 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 2.448720e-01 0.611 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.448720e-01 0.611 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 2.448720e-01 0.611 0 0
G2/M DNA replication checkpoint R-HSA-69478 2.448720e-01 0.611 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.448720e-01 0.611 0 0
Neurofascin interactions R-HSA-447043 2.448720e-01 0.611 0 0
Platelet degranulation R-HSA-114608 2.458913e-01 0.609 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.479709e-01 0.606 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 2.479709e-01 0.606 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.479709e-01 0.606 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.483957e-01 0.605 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 2.498313e-01 0.602 0 0
Suppression of phagosomal maturation R-HSA-9637687 2.498313e-01 0.602 0 0
Nucleotide Excision Repair R-HSA-5696398 2.566482e-01 0.591 0 0
Signaling by FGFR1 in disease R-HSA-5655302 2.610321e-01 0.583 0 0
Dual incision in TC-NER R-HSA-6782135 2.637649e-01 0.579 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 2.657976e-01 0.575 0 0
Calnexin/calreticulin cycle R-HSA-901042 2.657976e-01 0.575 0 0
Gap junction assembly R-HSA-190861 2.657976e-01 0.575 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.665172e-01 0.574 0 0
Formation of axial mesoderm R-HSA-9796292 2.665172e-01 0.574 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 2.665172e-01 0.574 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.665172e-01 0.574 0 0
CD28 dependent Vav1 pathway R-HSA-389359 2.665172e-01 0.574 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 2.694739e-01 0.569 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.694739e-01 0.569 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 2.694739e-01 0.569 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 2.708013e-01 0.567 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 2.708013e-01 0.567 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 2.708013e-01 0.567 0 0
IKBKB deficiency causes SCID R-HSA-5602636 2.708013e-01 0.567 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 2.708013e-01 0.567 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.708013e-01 0.567 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 2.708013e-01 0.567 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.708013e-01 0.567 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 2.708013e-01 0.567 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 2.708013e-01 0.567 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.708013e-01 0.567 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.708013e-01 0.567 0 0
Formation of definitive endoderm R-HSA-9823730 2.708048e-01 0.567 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.708048e-01 0.567 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.708048e-01 0.567 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.708048e-01 0.567 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.708048e-01 0.567 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.708048e-01 0.567 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 2.708048e-01 0.567 0 0
Protein hydroxylation R-HSA-9629569 2.708048e-01 0.567 0 0
Glycogen synthesis R-HSA-3322077 2.708048e-01 0.567 0 0
Neuronal System R-HSA-112316 2.792457e-01 0.554 1 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.834943e-01 0.547 0 0
Oncogene Induced Senescence R-HSA-2559585 2.834943e-01 0.547 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.835885e-01 0.547 0 0
Antigen processing-Cross presentation R-HSA-1236975 2.873102e-01 0.542 0 0
Inflammasomes R-HSA-622312 2.894344e-01 0.538 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.909174e-01 0.536 0 0
Adipogenesis R-HSA-9843745 2.917854e-01 0.535 0 0
Signaling by SCF-KIT R-HSA-1433557 2.932443e-01 0.533 0 0
Response of Mtb to phagocytosis R-HSA-9637690 2.932443e-01 0.533 0 0
ER to Golgi Anterograde Transport R-HSA-199977 2.935088e-01 0.532 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 2.939803e-01 0.532 0 0
Early Phase of HIV Life Cycle R-HSA-162594 2.939803e-01 0.532 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 2.939803e-01 0.532 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 2.939803e-01 0.532 0 0
Basigin interactions R-HSA-210991 2.939803e-01 0.532 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 2.939803e-01 0.532 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 2.948271e-01 0.530 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 2.948271e-01 0.530 0 0
HDL assembly R-HSA-8963896 2.948271e-01 0.530 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.003074e-01 0.522 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.028511e-01 0.519 0 0
Viral Messenger RNA Synthesis R-HSA-168325 3.055626e-01 0.515 0 0
Formation of paraxial mesoderm R-HSA-9793380 3.055626e-01 0.515 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.096458e-01 0.509 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.096458e-01 0.509 0 0
DARPP-32 events R-HSA-180024 3.096458e-01 0.509 0 0
Glucagon-type ligand receptors R-HSA-420092 3.096458e-01 0.509 0 0
Netrin-1 signaling R-HSA-373752 3.096741e-01 0.509 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 3.113005e-01 0.507 0 0
Sensory processing of sound R-HSA-9659379 3.125805e-01 0.505 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 3.155454e-01 0.501 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.173940e-01 0.498 0 0
Mitochondrial calcium ion transport R-HSA-8949215 3.173940e-01 0.498 0 0
Type I hemidesmosome assembly R-HSA-446107 3.221107e-01 0.492 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.221107e-01 0.492 0 0
MET receptor recycling R-HSA-8875656 3.221107e-01 0.492 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.221107e-01 0.492 0 0
Adrenoceptors R-HSA-390696 3.221107e-01 0.492 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 3.221107e-01 0.492 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 3.233067e-01 0.490 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.300423e-01 0.481 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 3.365780e-01 0.473 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 3.378830e-01 0.471 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.409474e-01 0.467 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.436702e-01 0.464 0 0
Signalling to ERK5 R-HSA-198765 3.436702e-01 0.464 0 0
Potassium transport channels R-HSA-1296067 3.436702e-01 0.464 0 0
Defective ABCB6 causes MCOPCB7 R-HSA-5683371 3.436702e-01 0.464 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.436702e-01 0.464 0 0
C6 deamination of adenosine R-HSA-75102 3.436702e-01 0.464 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.436702e-01 0.464 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 3.464348e-01 0.460 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.517896e-01 0.454 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 3.517896e-01 0.454 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 3.517896e-01 0.454 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.517896e-01 0.454 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 3.517896e-01 0.454 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.562913e-01 0.448 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 3.562913e-01 0.448 0 0
Lipophagy R-HSA-9613354 3.600912e-01 0.444 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 3.600912e-01 0.444 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.600912e-01 0.444 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 3.600912e-01 0.444 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.600912e-01 0.444 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.600912e-01 0.444 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.600912e-01 0.444 0 0
Regulated proteolysis of p75NTR R-HSA-193692 3.600912e-01 0.444 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.600912e-01 0.444 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 3.600912e-01 0.444 0 0
Interleukin-1 processing R-HSA-448706 3.600912e-01 0.444 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.600912e-01 0.444 0 0
Signaling by FGFR1 R-HSA-5654736 3.620317e-01 0.441 0 0
Cellular response to hypoxia R-HSA-1234174 3.633329e-01 0.440 0 0
Signaling by FGFR R-HSA-190236 3.638339e-01 0.439 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.640160e-01 0.439 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.645473e-01 0.438 0 0
DNA strand elongation R-HSA-69190 3.711387e-01 0.430 0 0
Inwardly rectifying K+ channels R-HSA-1296065 3.711387e-01 0.430 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 3.711387e-01 0.430 0 0
Diseases of Immune System R-HSA-5260271 3.747645e-01 0.426 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 3.747645e-01 0.426 0 0
IRE1alpha activates chaperones R-HSA-381070 3.766663e-01 0.424 0 0
GPER1 signaling R-HSA-9634597 3.767357e-01 0.424 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 3.778389e-01 0.423 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.801258e-01 0.420 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.801258e-01 0.420 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.881063e-01 0.411 0 0
Thromboxane signalling through TP receptor R-HSA-428930 3.881063e-01 0.411 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 3.881063e-01 0.411 0 0
Plasma lipoprotein assembly R-HSA-8963898 3.881063e-01 0.411 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 3.917185e-01 0.407 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 3.917185e-01 0.407 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 3.936671e-01 0.405 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 3.972537e-01 0.401 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 3.972537e-01 0.401 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.972537e-01 0.401 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 4.037157e-01 0.394 0 0
Regulated Necrosis R-HSA-5218859 4.074176e-01 0.390 0 0
Potential therapeutics for SARS R-HSA-9679191 4.080181e-01 0.389 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 4.081820e-01 0.389 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 4.081820e-01 0.389 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 4.081820e-01 0.389 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 4.081820e-01 0.389 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.092611e-01 0.388 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 4.092611e-01 0.388 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 4.092611e-01 0.388 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.092611e-01 0.388 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.092611e-01 0.388 0 0
MET activates PTPN11 R-HSA-8865999 4.092611e-01 0.388 0 0
MET interacts with TNS proteins R-HSA-8875513 4.092611e-01 0.388 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.092611e-01 0.388 0 0
Histamine receptors R-HSA-390650 4.092611e-01 0.388 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 4.115435e-01 0.386 0 0
G protein gated Potassium channels R-HSA-1296059 4.115435e-01 0.386 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 4.115435e-01 0.386 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 4.115435e-01 0.386 0 0
Sema4D in semaphorin signaling R-HSA-400685 4.115435e-01 0.386 0 0
Miscellaneous transport and binding events R-HSA-5223345 4.122444e-01 0.385 0 0
Signaling by TGFB family members R-HSA-9006936 4.152399e-01 0.382 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 4.277981e-01 0.369 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 4.326638e-01 0.364 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 4.326638e-01 0.364 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.333826e-01 0.363 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.333826e-01 0.363 0 0
Formation of the posterior neural plate R-HSA-9832991 4.333826e-01 0.363 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 4.333826e-01 0.363 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 4.333826e-01 0.363 0 0
Bicarbonate transporters R-HSA-425381 4.333826e-01 0.363 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.333826e-01 0.363 0 0
Interleukin-2 signaling R-HSA-9020558 4.333826e-01 0.363 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.347841e-01 0.362 0 0
Myogenesis R-HSA-525793 4.347841e-01 0.362 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.347841e-01 0.362 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.358406e-01 0.361 0 0
PKA activation in glucagon signalling R-HSA-164378 4.358406e-01 0.361 0 0
PKA activation R-HSA-163615 4.358406e-01 0.361 0 0
Platelet sensitization by LDL R-HSA-432142 4.358406e-01 0.361 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 4.372770e-01 0.359 0 0
Aquaporin-mediated transport R-HSA-445717 4.404842e-01 0.356 0 0
Integration of energy metabolism R-HSA-163685 4.444797e-01 0.352 0 0
TBC/RABGAPs R-HSA-8854214 4.484764e-01 0.348 0 0
Platelet activation, signaling and aggregation R-HSA-76002 4.485611e-01 0.348 0 0
Signalling to ERKs R-HSA-187687 4.529277e-01 0.344 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 4.549655e-01 0.342 0 0
Heme signaling R-HSA-9707616 4.560940e-01 0.341 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.577601e-01 0.339 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 4.577601e-01 0.339 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 4.577601e-01 0.339 0 0
Cristae formation R-HSA-8949613 4.577601e-01 0.339 0 0
Insulin processing R-HSA-264876 4.577601e-01 0.339 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 4.577601e-01 0.339 0 0
Transmission across Chemical Synapses R-HSA-112315 4.628103e-01 0.335 1 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 4.629994e-01 0.334 0 0
Specification of the neural plate border R-HSA-9834899 4.629994e-01 0.334 0 0
Proteasome assembly R-HSA-9907900 4.666678e-01 0.331 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.666678e-01 0.331 0 0
G1 Phase R-HSA-69236 4.666678e-01 0.331 0 0
Cyclin D associated events in G1 R-HSA-69231 4.666678e-01 0.331 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.683006e-01 0.329 0 0
HCN channels R-HSA-1296061 4.683006e-01 0.329 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.683006e-01 0.329 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.683006e-01 0.329 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.683006e-01 0.329 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.683006e-01 0.329 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.683006e-01 0.329 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.683006e-01 0.329 0 0
Regulation of gap junction activity R-HSA-191650 4.683006e-01 0.329 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.683006e-01 0.329 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.683006e-01 0.329 0 0
NADE modulates death signalling R-HSA-205025 4.683006e-01 0.329 0 0
Dopamine receptors R-HSA-390651 4.683006e-01 0.329 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 4.683006e-01 0.329 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.683006e-01 0.329 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 4.683135e-01 0.329 0 0
ERKs are inactivated R-HSA-202670 4.683135e-01 0.329 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.683135e-01 0.329 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 4.683135e-01 0.329 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.683135e-01 0.329 0 0
GPVI-mediated activation cascade R-HSA-114604 4.729905e-01 0.325 0 0
Triglyceride catabolism R-HSA-163560 4.729905e-01 0.325 0 0
Telomere Extension By Telomerase R-HSA-171319 4.804098e-01 0.318 0 0
HIV elongation arrest and recovery R-HSA-167287 4.804098e-01 0.318 0 0
Pausing and recovery of HIV elongation R-HSA-167290 4.804098e-01 0.318 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 4.804098e-01 0.318 0 0
Fanconi Anemia Pathway R-HSA-6783310 4.846950e-01 0.315 0 0
Ion transport by P-type ATPases R-HSA-936837 4.870487e-01 0.312 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 4.885887e-01 0.311 0 0
Co-inhibition by CTLA4 R-HSA-389513 4.895708e-01 0.310 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 4.895708e-01 0.310 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 4.895708e-01 0.310 0 0
RAF/MAP kinase cascade R-HSA-5673001 4.904250e-01 0.309 0 0
Signaling by FGFR in disease R-HSA-1226099 4.950957e-01 0.305 0 0
Stimuli-sensing channels R-HSA-2672351 4.961005e-01 0.304 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.019249e-01 0.299 0 0
Leading Strand Synthesis R-HSA-69109 5.019249e-01 0.299 0 0
Polymerase switching R-HSA-69091 5.019249e-01 0.299 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 5.019249e-01 0.299 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 5.019249e-01 0.299 0 0
OAS antiviral response R-HSA-8983711 5.019249e-01 0.299 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 5.025270e-01 0.299 0 0
Diseases of DNA repair R-HSA-9675135 5.025270e-01 0.299 0 0
Regulation of gene expression in beta cells R-HSA-210745 5.026781e-01 0.299 0 0
MET promotes cell motility R-HSA-8875878 5.123478e-01 0.290 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 5.154808e-01 0.288 0 0
Innate Immune System R-HSA-168249 5.161586e-01 0.287 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 5.201351e-01 0.284 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 5.214427e-01 0.283 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 5.214427e-01 0.283 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 5.214427e-01 0.283 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 5.214427e-01 0.283 0 0
IRS activation R-HSA-74713 5.214427e-01 0.283 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.214427e-01 0.283 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.214427e-01 0.283 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.214427e-01 0.283 0 0
Reelin signalling pathway R-HSA-8866376 5.214427e-01 0.283 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.214427e-01 0.283 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.214427e-01 0.283 0 0
Co-inhibition by BTLA R-HSA-9927353 5.214427e-01 0.283 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.214427e-01 0.283 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 5.214427e-01 0.283 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 5.245162e-01 0.280 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 5.245162e-01 0.280 0 0
DAP12 signaling R-HSA-2424491 5.245162e-01 0.280 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 5.245162e-01 0.280 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 5.267340e-01 0.278 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 5.315689e-01 0.274 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 5.341318e-01 0.272 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.341318e-01 0.272 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.341318e-01 0.272 0 0
Frs2-mediated activation R-HSA-170968 5.341318e-01 0.272 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.341318e-01 0.272 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 5.341318e-01 0.272 0 0
Intraflagellar transport R-HSA-5620924 5.374926e-01 0.270 0 0
Signaling by PDGFR in disease R-HSA-9671555 5.406679e-01 0.267 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 5.420930e-01 0.266 0 0
Downstream signal transduction R-HSA-186763 5.458813e-01 0.263 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 5.467179e-01 0.262 0 0
Transcription of the HIV genome R-HSA-167172 5.473347e-01 0.262 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 5.504417e-01 0.259 0 0
HIV Transcription Elongation R-HSA-167169 5.504417e-01 0.259 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 5.504417e-01 0.259 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 5.581916e-01 0.253 0 0
Extension of Telomeres R-HSA-180786 5.583935e-01 0.253 0 0
Regulation of beta-cell development R-HSA-186712 5.583935e-01 0.253 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 5.648792e-01 0.248 0 0
Removal of the Flap Intermediate R-HSA-69166 5.648792e-01 0.248 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 5.648792e-01 0.248 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.648792e-01 0.248 0 0
Physiological factors R-HSA-5578768 5.648792e-01 0.248 0 0
Malate-aspartate shuttle R-HSA-9856872 5.648792e-01 0.248 0 0
Zinc transporters R-HSA-435354 5.648792e-01 0.248 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 5.650825e-01 0.248 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 5.650825e-01 0.248 0 0
Signaling by WNT in cancer R-HSA-4791275 5.667364e-01 0.247 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.689383e-01 0.245 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 5.689383e-01 0.245 0 0
Plus-strand DNA synthesis R-HSA-164525 5.692763e-01 0.245 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.692763e-01 0.245 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.692763e-01 0.245 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 5.692763e-01 0.245 0 0
Phosphorylation of Emi1 R-HSA-176417 5.692763e-01 0.245 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.692763e-01 0.245 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.692763e-01 0.245 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.692763e-01 0.245 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.692763e-01 0.245 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.692763e-01 0.245 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.692763e-01 0.245 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.692763e-01 0.245 0 0
Signaling by MST1 R-HSA-8852405 5.692763e-01 0.245 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 5.692763e-01 0.245 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 5.692763e-01 0.245 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.692763e-01 0.245 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 5.692763e-01 0.245 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.715736e-01 0.243 0 0
Leishmania infection R-HSA-9658195 5.731669e-01 0.242 0 0
Parasitic Infection Pathways R-HSA-9824443 5.731669e-01 0.242 0 0
Signaling by NTRKs R-HSA-166520 5.778103e-01 0.238 0 0
Integrin signaling R-HSA-354192 5.870502e-01 0.231 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 5.870502e-01 0.231 0 0
Gastrulation R-HSA-9758941 5.876114e-01 0.231 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 5.886855e-01 0.230 0 0
Syndecan interactions R-HSA-3000170 5.886855e-01 0.230 0 0
Erythropoietin activates RAS R-HSA-9027284 5.941371e-01 0.226 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.941371e-01 0.226 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.941371e-01 0.226 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 5.941371e-01 0.226 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 5.941371e-01 0.226 0 0
Biotin transport and metabolism R-HSA-196780 5.941371e-01 0.226 0 0
Formation of the anterior neural plate R-HSA-9823739 5.941371e-01 0.226 0 0
Regulation of insulin secretion R-HSA-422356 5.958203e-01 0.225 0 0
Activation of GABAB receptors R-HSA-991365 6.047067e-01 0.218 0 0
GABA B receptor activation R-HSA-977444 6.047067e-01 0.218 0 0
Ion channel transport R-HSA-983712 6.054885e-01 0.218 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 6.067966e-01 0.217 0 0
Resolution of D-Loop Structures R-HSA-5693537 6.067966e-01 0.217 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 6.067966e-01 0.217 0 0
Signaling by LTK in cancer R-HSA-9842640 6.123312e-01 0.213 0 0
STAT5 Activation R-HSA-9645135 6.123312e-01 0.213 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.123312e-01 0.213 0 0
Uncoating of the HIV Virion R-HSA-162585 6.123312e-01 0.213 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 6.123312e-01 0.213 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.123312e-01 0.213 0 0
VLDL assembly R-HSA-8866423 6.123312e-01 0.213 0 0
MET Receptor Activation R-HSA-6806942 6.123312e-01 0.213 0 0
Phosphorylation of the APC/C R-HSA-176412 6.218960e-01 0.206 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 6.218960e-01 0.206 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.218960e-01 0.206 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 6.259544e-01 0.203 0 0
Signal amplification R-HSA-392518 6.259544e-01 0.203 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 6.259544e-01 0.203 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.333482e-01 0.198 0 0
Tight junction interactions R-HSA-420029 6.333482e-01 0.198 0 0
TGFBR3 expression R-HSA-9839394 6.333482e-01 0.198 0 0
HDMs demethylate histones R-HSA-3214842 6.333482e-01 0.198 0 0
Formation of the nephric duct R-HSA-9830364 6.333482e-01 0.198 0 0
FCERI mediated NF-kB activation R-HSA-2871837 6.341887e-01 0.198 0 0
Surfactant metabolism R-HSA-5683826 6.387142e-01 0.195 0 0
Amine ligand-binding receptors R-HSA-375280 6.387142e-01 0.195 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.481633e-01 0.188 0 0
Coenzyme A biosynthesis R-HSA-196783 6.481633e-01 0.188 0 0
Response to metal ions R-HSA-5660526 6.481633e-01 0.188 0 0
G alpha (z) signalling events R-HSA-418597 6.502146e-01 0.187 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.510846e-01 0.186 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.510846e-01 0.186 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.510846e-01 0.186 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.510846e-01 0.186 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.510846e-01 0.186 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.510846e-01 0.186 0 0
Disinhibition of SNARE formation R-HSA-114516 6.510846e-01 0.186 0 0
SOS-mediated signalling R-HSA-112412 6.510846e-01 0.186 0 0
Recycling of eIF2:GDP R-HSA-72731 6.510846e-01 0.186 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.510846e-01 0.186 0 0
Mitochondrial ABC transporters R-HSA-1369007 6.510846e-01 0.186 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 6.510846e-01 0.186 0 0
Ca2+ activated K+ channels R-HSA-1296052 6.510846e-01 0.186 0 0
LDL remodeling R-HSA-8964041 6.510846e-01 0.186 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.510846e-01 0.186 0 0
CHL1 interactions R-HSA-447041 6.510846e-01 0.186 0 0
Maturation of replicase proteins R-HSA-9694301 6.510846e-01 0.186 0 0
RUNX2 regulates bone development R-HSA-8941326 6.624423e-01 0.179 0 0
Metabolism of proteins R-HSA-392499 6.626625e-01 0.179 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 6.648747e-01 0.177 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 6.648747e-01 0.177 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 6.708482e-01 0.173 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 6.708482e-01 0.173 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 6.708482e-01 0.173 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 6.708482e-01 0.173 0 0
Unfolded Protein Response (UPR) R-HSA-381119 6.715557e-01 0.173 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 6.729597e-01 0.172 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.729597e-01 0.172 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 6.745205e-01 0.171 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 6.745205e-01 0.171 0 0
RSV-host interactions R-HSA-9833110 6.752176e-01 0.171 0 0
Hemostasis R-HSA-109582 6.768229e-01 0.170 0 0
Parasite infection R-HSA-9664407 6.807638e-01 0.167 0 0
Leishmania phagocytosis R-HSA-9664417 6.807638e-01 0.167 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 6.807638e-01 0.167 0 0
Reverse Transcription of HIV RNA R-HSA-162589 6.859661e-01 0.164 0 0
Minus-strand DNA synthesis R-HSA-164516 6.859661e-01 0.164 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.859661e-01 0.164 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 6.859661e-01 0.164 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.859661e-01 0.164 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 6.859661e-01 0.164 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 6.859661e-01 0.164 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.859661e-01 0.164 0 0
Fructose biosynthesis R-HSA-5652227 6.859661e-01 0.164 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.859661e-01 0.164 0 0
SLC-mediated bile acid transport R-HSA-9958517 6.859661e-01 0.164 0 0
Sodium/Proton exchangers R-HSA-425986 6.859661e-01 0.164 0 0
Interleukin-23 signaling R-HSA-9020933 6.859661e-01 0.164 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 6.937865e-01 0.159 0 0
Formation of the Early Elongation Complex R-HSA-113418 6.937865e-01 0.159 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 6.937865e-01 0.159 0 0
Platelet homeostasis R-HSA-418346 6.961428e-01 0.157 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.963167e-01 0.157 0 0
Apoptotic factor-mediated response R-HSA-111471 6.963167e-01 0.157 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.963167e-01 0.157 0 0
Nephron development R-HSA-9831926 6.963167e-01 0.157 0 0
NGF-stimulated transcription R-HSA-9031628 7.010385e-01 0.154 0 0
Peroxisomal protein import R-HSA-9033241 7.064738e-01 0.151 0 0
Signaling by Erythropoietin R-HSA-9006335 7.121779e-01 0.147 0 0
mRNA Capping R-HSA-72086 7.121779e-01 0.147 0 0
Signaling by ALK R-HSA-201556 7.124776e-01 0.147 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.124776e-01 0.147 0 0
RAS processing R-HSA-9648002 7.124776e-01 0.147 0 0
Plasma lipoprotein clearance R-HSA-8964043 7.124776e-01 0.147 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 7.173623e-01 0.144 0 0
ALK mutants bind TKIs R-HSA-9700645 7.173623e-01 0.144 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 7.173623e-01 0.144 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.173623e-01 0.144 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.173623e-01 0.144 0 0
mRNA Editing R-HSA-75072 7.173623e-01 0.144 0 0
WNT mediated activation of DVL R-HSA-201688 7.173623e-01 0.144 0 0
Cellular response to mitochondrial stress R-HSA-9840373 7.173623e-01 0.144 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.173623e-01 0.144 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.173623e-01 0.144 0 0
Germ layer formation at gastrulation R-HSA-9754189 7.182744e-01 0.144 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.182744e-01 0.144 0 0
E2F mediated regulation of DNA replication R-HSA-113510 7.182744e-01 0.144 0 0
FOXO-mediated transcription R-HSA-9614085 7.197103e-01 0.143 0 0
Interleukin-2 family signaling R-HSA-451927 7.278940e-01 0.138 0 0
Azathioprine ADME R-HSA-9748787 7.292522e-01 0.137 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 7.297048e-01 0.137 0 0
Activation of BH3-only proteins R-HSA-114452 7.297048e-01 0.137 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 7.319709e-01 0.136 0 0
Disease R-HSA-1643685 7.344433e-01 0.134 1 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 7.388789e-01 0.131 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 7.388789e-01 0.131 0 0
Signal transduction by L1 R-HSA-445144 7.388789e-01 0.131 0 0
Creatine metabolism R-HSA-71288 7.388789e-01 0.131 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 7.395932e-01 0.131 0 0
The phototransduction cascade R-HSA-2514856 7.426164e-01 0.129 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 7.446041e-01 0.128 0 0
Binding and entry of HIV virion R-HSA-173107 7.456213e-01 0.127 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.456213e-01 0.127 0 0
PI3K/AKT activation R-HSA-198203 7.456213e-01 0.127 0 0
Signal attenuation R-HSA-74749 7.456213e-01 0.127 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.456213e-01 0.127 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.456213e-01 0.127 0 0
Tandem pore domain potassium channels R-HSA-1296346 7.456213e-01 0.127 0 0
Signaling by Leptin R-HSA-2586552 7.456213e-01 0.127 0 0
Formation of apoptosome R-HSA-111458 7.456213e-01 0.127 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 7.568541e-01 0.121 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.568541e-01 0.121 0 0
Translation of Structural Proteins R-HSA-9683701 7.568541e-01 0.121 0 0
Lagging Strand Synthesis R-HSA-69186 7.581813e-01 0.120 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 7.704130e-01 0.113 0 0
vRNA Synthesis R-HSA-192814 7.710564e-01 0.113 0 0
vRNP Assembly R-HSA-192905 7.710564e-01 0.113 0 0
Chylomicron assembly R-HSA-8963888 7.710564e-01 0.113 0 0
Synthesis of PI R-HSA-1483226 7.710564e-01 0.113 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 7.710564e-01 0.113 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 7.710564e-01 0.113 0 0
PECAM1 interactions R-HSA-210990 7.710564e-01 0.113 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.710564e-01 0.113 0 0
tRNA processing R-HSA-72306 7.735333e-01 0.112 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 7.762360e-01 0.110 0 0
Ribavirin ADME R-HSA-9755088 7.762360e-01 0.110 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 7.801966e-01 0.108 0 0
Translation of Structural Proteins R-HSA-9694635 7.890798e-01 0.103 0 0
Potassium Channels R-HSA-1296071 7.914139e-01 0.102 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 7.914947e-01 0.102 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.930994e-01 0.101 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.930994e-01 0.101 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 7.939495e-01 0.100 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.939495e-01 0.100 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 7.939495e-01 0.100 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 7.939495e-01 0.100 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 7.939495e-01 0.100 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 7.939495e-01 0.100 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 7.939495e-01 0.100 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 7.939495e-01 0.100 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 7.939495e-01 0.100 0 0
DAP12 interactions R-HSA-2172127 7.957399e-01 0.099 0 0
Interferon alpha/beta signaling R-HSA-909733 7.957485e-01 0.099 0 0
eNOS activation R-HSA-203615 8.049680e-01 0.094 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.049680e-01 0.094 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 8.075333e-01 0.093 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.088291e-01 0.092 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.088291e-01 0.092 0 0
Interleukin receptor SHC signaling R-HSA-912526 8.088291e-01 0.092 0 0
Growth hormone receptor signaling R-HSA-982772 8.088291e-01 0.092 0 0
Mitochondrial biogenesis R-HSA-1592230 8.109996e-01 0.091 1 0
Scavenging by Class F Receptors R-HSA-3000484 8.145547e-01 0.089 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.145547e-01 0.089 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.145547e-01 0.089 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.145547e-01 0.089 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.145547e-01 0.089 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 8.145547e-01 0.089 0 0
Regulation of IFNG signaling R-HSA-877312 8.145547e-01 0.089 0 0
Interleukin-15 signaling R-HSA-8983432 8.145547e-01 0.089 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.145547e-01 0.089 0 0
Post-translational protein modification R-HSA-597592 8.156476e-01 0.088 0 0
Signaling by TGFBR3 R-HSA-9839373 8.187657e-01 0.087 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 8.234833e-01 0.084 0 0
Complex III assembly R-HSA-9865881 8.234833e-01 0.084 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 8.254742e-01 0.083 1 1
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.276416e-01 0.082 0 0
Interferon gamma signaling R-HSA-877300 8.318126e-01 0.080 0 0
Triglyceride metabolism R-HSA-8979227 8.323035e-01 0.080 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.331005e-01 0.079 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 8.331005e-01 0.079 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.331005e-01 0.079 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 8.331005e-01 0.079 0 0
Interleukin-6 signaling R-HSA-1059683 8.331005e-01 0.079 0 0
Neddylation R-HSA-8951664 8.348423e-01 0.078 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 8.371197e-01 0.077 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.398048e-01 0.076 0 0
GABA receptor activation R-HSA-977443 8.414812e-01 0.075 0 0
tRNA Aminoacylation R-HSA-379724 8.414812e-01 0.075 0 0
Metabolism of polyamines R-HSA-351202 8.414812e-01 0.075 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.417266e-01 0.075 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 8.450072e-01 0.073 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.497925e-01 0.071 0 0
cGMP effects R-HSA-418457 8.497925e-01 0.071 0 0
Signaling by FGFR4 in disease R-HSA-5655291 8.497925e-01 0.071 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.497925e-01 0.071 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.497952e-01 0.071 0 0
Urea cycle R-HSA-70635 8.497952e-01 0.071 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.497952e-01 0.071 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.517236e-01 0.070 0 0
Formation of the cornified envelope R-HSA-6809371 8.577120e-01 0.067 0 0
Mitochondrial protein import R-HSA-1268020 8.585956e-01 0.066 0 0
Signaling by PDGF R-HSA-186797 8.585956e-01 0.066 0 0
Protein localization R-HSA-9609507 8.587310e-01 0.066 0 0
Signaling by BMP R-HSA-201451 8.615656e-01 0.065 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.648160e-01 0.063 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.648160e-01 0.063 0 0
Protein lipoylation R-HSA-9857492 8.648160e-01 0.063 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.648160e-01 0.063 0 0
Signaling by Activin R-HSA-1502540 8.648160e-01 0.063 0 0
p38MAPK events R-HSA-171007 8.648160e-01 0.063 0 0
Other semaphorin interactions R-HSA-416700 8.648160e-01 0.063 0 0
DNA Damage Reversal R-HSA-73942 8.648160e-01 0.063 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.665563e-01 0.062 0 0
Iron uptake and transport R-HSA-917937 8.680077e-01 0.061 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.712053e-01 0.060 0 0
Pyroptosis R-HSA-5620971 8.724852e-01 0.059 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.752842e-01 0.058 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 8.783377e-01 0.056 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.783377e-01 0.056 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.783377e-01 0.056 0 0
Phase 4 - resting membrane potential R-HSA-5576886 8.783377e-01 0.056 0 0
Activation of the phototransduction cascade R-HSA-2485179 8.783377e-01 0.056 0 0
Activation of SMO R-HSA-5635838 8.783377e-01 0.056 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.783377e-01 0.056 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 8.783377e-01 0.056 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.783377e-01 0.056 0 0
Killing mechanisms R-HSA-9664420 8.783377e-01 0.056 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 8.783377e-01 0.056 0 0
Attachment and Entry R-HSA-9678110 8.783377e-01 0.056 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 8.800701e-01 0.055 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 8.826062e-01 0.054 0 0
Platelet calcium homeostasis R-HSA-418360 8.826062e-01 0.054 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 8.830523e-01 0.054 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.883877e-01 0.051 0 0
HIV Transcription Initiation R-HSA-167161 8.883877e-01 0.051 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.883877e-01 0.051 0 0
Intra-Golgi traffic R-HSA-6811438 8.883877e-01 0.051 0 0
Glycine degradation R-HSA-6783984 8.905076e-01 0.050 0 0
Phase 2 - plateau phase R-HSA-5576893 8.905076e-01 0.050 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 8.905076e-01 0.050 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.905076e-01 0.050 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 8.905076e-01 0.050 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 8.905076e-01 0.050 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 8.905076e-01 0.050 0 0
Passive transport by Aquaporins R-HSA-432047 8.905076e-01 0.050 0 0
Galactose catabolism R-HSA-70370 8.905076e-01 0.050 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.905076e-01 0.050 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 8.905076e-01 0.050 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 8.919791e-01 0.050 0 0
Kidney development R-HSA-9830369 8.947133e-01 0.048 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 8.948117e-01 0.048 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.965896e-01 0.047 0 0
Disorders of transmembrane transporters R-HSA-5619115 8.993548e-01 0.046 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.006524e-01 0.045 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.006524e-01 0.045 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.014608e-01 0.045 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.014608e-01 0.045 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.014608e-01 0.045 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 9.014608e-01 0.045 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 9.014608e-01 0.045 0 0
Catecholamine biosynthesis R-HSA-209905 9.014608e-01 0.045 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.014608e-01 0.045 0 0
Choline catabolism R-HSA-6798163 9.014608e-01 0.045 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.034797e-01 0.044 0 0
Inositol phosphate metabolism R-HSA-1483249 9.034797e-01 0.044 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.034891e-01 0.044 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.086721e-01 0.042 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 9.113189e-01 0.040 0 0
Synaptic adhesion-like molecules R-HSA-8849932 9.113189e-01 0.040 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.113189e-01 0.040 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.113189e-01 0.040 0 0
Cardiogenesis R-HSA-9733709 9.160822e-01 0.038 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.167187e-01 0.038 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.201912e-01 0.036 0 0
Other interleukin signaling R-HSA-449836 9.201912e-01 0.036 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 9.201912e-01 0.036 0 0
Maturation of nucleoprotein R-HSA-9694631 9.201912e-01 0.036 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 9.225633e-01 0.035 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.229243e-01 0.035 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.229243e-01 0.035 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.281764e-01 0.032 0 0
Signaling by NODAL R-HSA-1181150 9.281764e-01 0.032 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.281764e-01 0.032 0 0
Pregnenolone biosynthesis R-HSA-196108 9.281764e-01 0.032 0 0
RA biosynthesis pathway R-HSA-5365859 9.292379e-01 0.032 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.313615e-01 0.031 0 0
Peptide hormone metabolism R-HSA-2980736 9.320115e-01 0.031 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.334606e-01 0.030 0 0
Metal ion SLC transporters R-HSA-425410 9.334817e-01 0.030 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.350603e-01 0.029 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.353630e-01 0.029 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.353630e-01 0.029 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.353630e-01 0.029 0 0
Signalling to RAS R-HSA-167044 9.353630e-01 0.029 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.353630e-01 0.029 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.353630e-01 0.029 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.394675e-01 0.027 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.404264e-01 0.027 0 0
Glycosphingolipid transport R-HSA-9845576 9.404264e-01 0.027 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.404264e-01 0.027 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.418310e-01 0.026 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.418310e-01 0.026 0 0
Serine metabolism R-HSA-977347 9.418310e-01 0.026 0 0
Glutathione synthesis and recycling R-HSA-174403 9.418310e-01 0.026 0 0
Attachment and Entry R-HSA-9694614 9.418310e-01 0.026 0 0
PI3K Cascade R-HSA-109704 9.428659e-01 0.026 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.428659e-01 0.026 0 0
IGF1R signaling cascade R-HSA-2428924 9.442239e-01 0.025 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.476520e-01 0.023 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.476520e-01 0.023 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.476520e-01 0.023 0 0
Fructose metabolism R-HSA-5652084 9.476520e-01 0.023 0 0
Cellular hexose transport R-HSA-189200 9.476520e-01 0.023 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.477578e-01 0.023 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.479956e-01 0.023 0 0
Elastic fibre formation R-HSA-1566948 9.499199e-01 0.022 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.499199e-01 0.022 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.499199e-01 0.022 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.503370e-01 0.022 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.505568e-01 0.022 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.510086e-01 0.022 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.528909e-01 0.021 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.528909e-01 0.021 0 0
Formation of the ureteric bud R-HSA-9830674 9.528909e-01 0.021 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.528909e-01 0.021 0 0
Carnitine shuttle R-HSA-200425 9.528909e-01 0.021 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.541072e-01 0.020 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 9.541072e-01 0.020 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.546611e-01 0.020 0 0
Nucleotide biosynthesis R-HSA-8956320 9.546611e-01 0.020 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.576057e-01 0.019 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.576057e-01 0.019 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.576057e-01 0.019 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.576057e-01 0.019 0 0
Interleukin-6 family signaling R-HSA-6783589 9.576057e-01 0.019 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.579583e-01 0.019 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.584977e-01 0.018 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.607933e-01 0.017 0 0
Maturation of spike protein R-HSA-9694548 9.614986e-01 0.017 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.618489e-01 0.017 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.618489e-01 0.017 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.618489e-01 0.017 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.618489e-01 0.017 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.618489e-01 0.017 0 0
Interleukin-7 signaling R-HSA-1266695 9.618489e-01 0.017 0 0
COPII-mediated vesicle transport R-HSA-204005 9.635747e-01 0.016 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.653271e-01 0.015 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.653271e-01 0.015 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.656677e-01 0.015 0 0
TRP channels R-HSA-3295583 9.656677e-01 0.015 0 0
Sphingolipid catabolism R-HSA-9845614 9.656677e-01 0.015 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 9.656677e-01 0.015 0 0
Dectin-2 family R-HSA-5621480 9.668691e-01 0.015 0 0
IRS-mediated signalling R-HSA-112399 9.668691e-01 0.015 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.677394e-01 0.014 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.691044e-01 0.014 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.691044e-01 0.014 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.691044e-01 0.014 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 9.691044e-01 0.014 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.691044e-01 0.014 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.693956e-01 0.013 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.707132e-01 0.013 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.710759e-01 0.013 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.717391e-01 0.012 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.739118e-01 0.011 0 0
Thyroxine biosynthesis R-HSA-209968 9.749806e-01 0.011 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.749806e-01 0.011 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.749806e-01 0.011 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.759417e-01 0.011 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.774856e-01 0.010 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.774856e-01 0.010 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.774856e-01 0.010 0 0
Neurotransmitter clearance R-HSA-112311 9.774856e-01 0.010 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.777904e-01 0.010 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.777904e-01 0.010 0 0
Synthesis of PC R-HSA-1483191 9.793685e-01 0.009 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.795273e-01 0.009 0 0
Cargo concentration in the ER R-HSA-5694530 9.797398e-01 0.009 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.797398e-01 0.009 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.797398e-01 0.009 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.797785e-01 0.009 0 0
Insulin receptor signalling cascade R-HSA-74751 9.811158e-01 0.008 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.811476e-01 0.008 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.812405e-01 0.008 0 0
DAG1 glycosylations R-HSA-8931838 9.817685e-01 0.008 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.834453e-01 0.007 0 0
Nuclear RNA decay R-HSA-9930044 9.835941e-01 0.007 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 9.835941e-01 0.007 0 0
Recycling of bile acids and salts R-HSA-159418 9.835941e-01 0.007 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.839623e-01 0.007 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.845823e-01 0.007 0 0
Collagen formation R-HSA-1474290 9.845823e-01 0.007 0 0
Extracellular matrix organization R-HSA-1474244 9.851976e-01 0.006 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.852370e-01 0.006 0 0
Heme degradation R-HSA-189483 9.852370e-01 0.006 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.863951e-01 0.006 0 0
PPARA activates gene expression R-HSA-1989781 9.866466e-01 0.006 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.867155e-01 0.006 0 0
G alpha (q) signalling events R-HSA-416476 9.870674e-01 0.006 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.877573e-01 0.005 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.880460e-01 0.005 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.880460e-01 0.005 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.880460e-01 0.005 0 0
PERK regulates gene expression R-HSA-381042 9.880460e-01 0.005 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.891390e-01 0.005 0 0
Paracetamol ADME R-HSA-9753281 9.900353e-01 0.004 0 0
Voltage gated Potassium channels R-HSA-1296072 9.903208e-01 0.004 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.903208e-01 0.004 0 0
NCAM1 interactions R-HSA-419037 9.903208e-01 0.004 0 0
Collagen chain trimerization R-HSA-8948216 9.903208e-01 0.004 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.909104e-01 0.004 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.917691e-01 0.004 0 0
PI Metabolism R-HSA-1483255 9.919757e-01 0.003 0 0
Pentose phosphate pathway R-HSA-71336 9.921629e-01 0.003 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.924131e-01 0.003 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.929480e-01 0.003 0 0
SLC transporter disorders R-HSA-5619102 9.934602e-01 0.003 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.937186e-01 0.003 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.941142e-01 0.003 0 0
Collagen degradation R-HSA-1442490 9.942754e-01 0.002 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.942904e-01 0.002 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.942904e-01 0.002 0 0
Heme biosynthesis R-HSA-189451 9.942904e-01 0.002 0 0
G alpha (s) signalling events R-HSA-418555 9.951897e-01 0.002 0 0
Complex I biogenesis R-HSA-6799198 9.952478e-01 0.002 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.958405e-01 0.002 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.962574e-01 0.002 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.975350e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.975350e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.975470e-01 0.001 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.975470e-01 0.001 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.977115e-01 0.001 0 0
Metabolism of porphyrins R-HSA-189445 9.977570e-01 0.001 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.979607e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.980142e-01 0.001 0 0
Neurotransmitter release cycle R-HSA-112310 9.980827e-01 0.001 0 0
Aspirin ADME R-HSA-9749641 9.981434e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.981988e-01 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.983112e-01 0.001 0 0
Signaling by Insulin receptor R-HSA-74752 9.985265e-01 0.001 0 0
G alpha (i) signalling events R-HSA-418594 9.986707e-01 0.001 1 0
Keratinization R-HSA-6805567 9.988376e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.988449e-01 0.001 0 0
Integrin cell surface interactions R-HSA-216083 9.988454e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.989466e-01 0.000 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.990523e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.990529e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.990777e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.991473e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.992328e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.992748e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.993582e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.994974e-01 0.000 0 0
Glycosphingolipid biosynthesis R-HSA-9840309 9.994974e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.996340e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.996340e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.996707e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.997370e-01 0.000 1 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.997603e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.997603e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.997603e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.997749e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.997843e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.997957e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.998430e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.998474e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.998688e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.998700e-01 0.000 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.998729e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.998744e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999229e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999378e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999378e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999394e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999456e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999495e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999559e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999612e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999621e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999752e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999754e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999800e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999885e-01 0.000 1 0
Sphingolipid metabolism R-HSA-428157 9.999945e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999952e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999958e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999971e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999985e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999987e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999991e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999994e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999995e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999996e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999996e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999996e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999998e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999998e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999999e-01 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways