PBK

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
O00488	S93	Sugiyama	ZNF593 ZT86	STNLKTHFRSKDHKKRLKQLsVEPysQEEAERAAGMGSYVP
O14974	S695	Sugiyama	PPP1R12A MBS MYPT1	DEEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSR
O14974	T696	Sugiyama	PPP1R12A MBS MYPT1	EEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSRS
O14974	T702	Sugiyama	PPP1R12A MBS MYPT1	RKARSRQARQsRRstQGVtLtDLQEAEKtIGRSRSTRTREQ
O15371	T46	Sugiyama	EIF3D EIF3S7	RDMPyQPFsKGDRLGKVADWtGAtyQDKRYTNKYSSQFGGG
O43390	T134	Sugiyama	HNRNPR HNRPR	KVQESTKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDS
O43390	T141	Sugiyama	HNRNPR HNRPR	GPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVYSGVQP
O43390	T142	Sugiyama	HNRNPR HNRPR	PDEAKIKALLERtGytLDVttGQRKYGGPPPDSVYSGVQPG
O43390	Y136	Sugiyama	HNRNPR HNRPR	QESTKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVY
O43615	T198	Sugiyama	TIMM44 MIMT44 TIM44	ALsQGVEsVKKEIDDsVLGQtGPyRRPQRLRKRTEFAGDKF
O43663	T481	EPSD	PRC1	EMLyGsAPRtPsKRRGLAPNtPGKARKLNTttMsNAtANss
O60506	T131	Sugiyama	SYNCRIP HNRPQ NSAP1	KVADSSKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDS
O60506	T138	Sugiyama	SYNCRIP HNRPQ NSAP1	GPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVYSGQQP
O60506	T139	Sugiyama	SYNCRIP HNRPQ NSAP1	PDEAKIKALLERtGytLDVttGQRKYGGPPPDSVYSGQQPs
O60506	Y133	Sugiyama	SYNCRIP HNRPQ NSAP1	ADSSKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVY
O60739	T45	Sugiyama	EIF1B	AGTEDyIHIRIQQRNGRKtLttVQGIADDyDKKKLVKAFKK
O60828	T219	Sugiyama	PQBP1 NPW38 JM26	EELDPMDPSsysDAPRGTWstGLPKRNEAKTGADttAAGPL
O75385	S469	SIGNOR\|PSP	ULK1 KIAA0722	QsPtQFQtPRSSAIRRsGstsPLGFARAsPsPPAHAEHGGV
O75385	S495	SIGNOR\|PSP	ULK1 KIAA0722	RAsPsPPAHAEHGGVLARKMsLGGGRPYTPSPQVGTIPERP
O75385	S533	SIGNOR\|PSP	ULK1 KIAA0722	ERPGWSGtPsPQGAEMRGGRsPRPGssAPEHsPRTSGLGCR
O75533	T203	Sugiyama	SF3B1 SAP155	VVNGAAAsQPPsKRKRRWDQtADQtPGAtPKKLssWDQAEt
O75821	T174	Sugiyama	EIF3G EIF3S4	IVSCRICKGDHWTTRCPYKDtLGPMQKELAEQLGLstGEKE
O75821	T190	Sugiyama	EIF3G EIF3S4	PYKDtLGPMQKELAEQLGLstGEKEKLPGELEPVQAtQNKt
O95365	T461	Sugiyama	ZBTB7A FBI1 LRF ZBTB7 ZNF857A	QQCGAAFAHNYDLKNHMRVHtGLRPYQCDSCCKTFVRSDHL
P00338	S161	Sugiyama	LDHA PIG19	DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00558	T168	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	EAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGF
P04040	S515	Sugiyama	CAT	ALLDKYNAEKPKNAIHtFVQsGsHLAAREKANL________
P04040	T29	Sugiyama	CAT	SDQMQHWKEQRAAQKADVLttGAGNPVGDKLNVItVGPRGP
P04040	T434	Sugiyama	CAT	QQPSALEHSIQYSGEVRRFNtANDDNVtQVRAFyVNVLNEE
P04040	T511	Sugiyama	CAT	SHIQALLDKYNAEKPKNAIHtFVQsGsHLAAREKANL____
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075	T37	Sugiyama	ALDOA ALDA	sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04075	T49	Sugiyama	ALDOA ALDA	GILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtADDR
P04406	S210	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	GPsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtG
P04406	T211	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	PsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtGM
P04406	T237	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05412	S63	EPSD\|PSP	JUN	ADPVGSLKPHLRAKNsDLLtsPDVGLLKLAsPELERLIIQS
P05412	S73	EPSD\|PSP	JUN	LRAKNsDLLtsPDVGLLKLAsPELERLIIQSSNGHItttPt
P05455	T120	Sugiyama	SSB	VTDEyKNDVKNRsVYIKGFPtDAtLDDIKEWLEDKGQVLNI
P06733	S37	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	NPtVEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRY
P06733	T205	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06733	T26	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	IHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEA
P06733	T41	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	EVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKG
P06748	T279	Sugiyama	NPM1 NPM	GsLPKVEAKFINyVKNCFRMtDQEAIQDLWQWRKsL_____
P07195	S162	Sugiyama	LDHB	DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195	T302	Sugiyama	LDHB	YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07205	T168	Sugiyama	PGK2 PGKB	EAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNLPHKASGF
P07237	S88	Sugiyama	P4HB ERBA2L PDI PDIA1 PO4DB	GKLKAEGSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNG
P07437	T55	Sugiyama	TUBB TUBB5 OK/SW-cl.56	tyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEPGtMDs
P07711	T332	Sugiyama	CTSL CTSL1	VKMAKDRRNHCGIAsAAsyPtV___________________
P07864	S161	Sugiyama	LDHC LDH3 LDHX	DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P08195	T599	Sugiyama	SLC3A2 MDU1	QASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEPH
P08238	S462	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238	T83	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	sKLDsGKELKIDIIPNPQERtLtLVDtGIGMtKADLINNLG
P08238	T85	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	LDsGKELKIDIIPNPQERtLtLVDtGIGMtKADLINNLGtI
P08238	T89	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	KELKIDIIPNPQERtLtLVDtGIGMtKADLINNLGtIAKSG
P08758	T111	Sugiyama	ANXA5 ANX5 ENX2 PP4	yDAyELKHALKGAGTNEKVLtEIIAsRtPEELRAIKQVyEE
P08865	T94	Sugiyama	RPSA LAMBR LAMR1	VsVIssRNtGQRAVLKFAAAtGAtPIAGRFtPGTFTNQIQA
P0DPH7	T56	Sugiyama	TUBA3C TUBA2	MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVVD
P10412	S55	Sugiyama	H1-4 H1F4 HIST1H1E	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P10809	T231	Sugiyama	HSPD1 HSP60	LEIIEGMKFDRGyIsPyFINtsKGQKCEFQDAyVLLsEKKI
P11142	S85	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	NtVFDAKRLIGRRFDDAVVQsDMKHWPFMVVNDAGRPKVQV
P11142	T222	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	GGTFDVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFI
P11142	T45	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtN
P11142	T66	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P11940	T191	Sugiyama	PABPC1 PAB1 PABP PABP1 PABPC2	GRFKSRKEREAELGARAKEFtNVyIKNFGEDMDDERLKDLF
P12277	T322	Sugiyama	CKB CKBB	LGKHEKFsEVLKRLRLQKRGtGGVDtAAVGGVFDVsNADRL
P12277	T327	Sugiyama	CKB CKBB	KFsEVLKRLRLQKRGtGGVDtAAVGGVFDVsNADRLGFSEV
P12956	S306	Sugiyama	XRCC6 G22P1	IKLYRETNEPVKTKTRtFNtstGGLLLPsDtKRSQIYGSRQ
P12956	T305	Sugiyama	XRCC6 G22P1	PIKLYRETNEPVKTKTRtFNtstGGLLLPsDtKRSQIYGSR
P12956	T307	Sugiyama	XRCC6 G22P1	KLYRETNEPVKTKTRtFNtstGGLLLPsDtKRSQIYGSRQI
P13639	T735	Sugiyama	EEF2 EF2	HRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQCPEQV
P14314	T469	Sugiyama	PRKCSH G19P1	WGsWIGPDHDKFSAMKyEQGtGCWQGPNRstTVRLLCGKEt
P14618	T45	Sugiyama	PKM OIP3 PK2 PK3 PKM2	TFLEHMCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMI
P14618	T50	Sugiyama	PKM OIP3 PK2 PK3 PKM2	MCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMIKsGMN
P14625	T519	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	DHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQDKIy
P15311	T533	Sugiyama	EZR VIL2	NEEKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDII
P15880	T202	Sugiyama	RPS2 RPS4	CKVTGRCGsVLVRLIPAPRGtGIVsAPVPKKLLMMAGIDDC
P15880	T285	Sugiyama	RPS2 RPS4	PyQEFtDHLVKtHtRVsVQRtQAPAVATt____________
P16402	S56	Sugiyama	H1-3 H1F3 HIST1H1D	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403	S55	Sugiyama	H1-2 H1F2 HIST1H1C	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P17066	T47	Sugiyama	HSPA6 HSP70B'	RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P18124	T170	Sugiyama	RPL7	VNELIyKRGYGKINKKRIALtDNALIARSLGKyGIICMEDL
P19338	T464	Sugiyama	NCL	KTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNSTWsGE
P21108	S8	Sugiyama	PRPS1L1 PRPS3 PRPSL	_____________MPNIKIFsGssHQDLSQKIADRLGLELG
P23284	T81	Sugiyama	PPIB CYPB	IFGLFGKTVPKTVDNFVALAtGEKGFGYKNSKFHRVIKDFM
P23396	T242	Sugiyama	RPS3 OK/SW-cl.26	PIsEQKGGKPEPPAMPQPVPtA___________________
P26038	T526	Sugiyama	MSN	EERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHA
P26373	T107	Sugiyama	RPL13 BBC1 OK/SW-cl.46	HKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILF
P26373	T148	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373	T151	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P26373	T24	Sugiyama	RPL13 BBC1 OK/SW-cl.46	SRNGMVLKPHFHKDWQRRVAtWFNQPARKIRRRKARQAKAR
P26641	S25	Sugiyama	EEF1G EF1G PRO1608	TLyTyPENWRAFKALIAAQYsGAQVRVLsAPPHFHFGQtNR
P26641	T287	Sugiyama	EEF1G EF1G PRO1608	EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P27797	S52	Sugiyama	CALR CRTC	GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P29401	T442	Sugiyama	TKT	GEDGPSQMALEDLAMFRsVPtstVFyPsDGVAtEKAVELAA
P30050	T135	Sugiyama	RPL12	QMRHRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDI
P30050	T18	Sugiyama	RPL12	___MPPKFDPNEIKVVYLRCtGGEVGAtsALAPKIGPLGLs
P30050	T25	Sugiyama	RPL12	FDPNEIKVVYLRCtGGEVGAtsALAPKIGPLGLsPKKVGDD
P30086	T69	Sugiyama	PEBP1 PBP PEBP	RPtsIsWDGLDsGKLytLVLtDPDAPsRKDPKYREWHHFLV
P30101	T485	Sugiyama	PDIA3 ERP57 ERP60 GRP58	KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P31943	S269	Sugiyama	HNRNPH1 HNRPH HNRPH1	YNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGstFQsttGH
P34931	T47	Sugiyama	HSPA1L	KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQN
P36578	S66	Sugiyama	RPL4 RPL1	KNNRQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGGGtHR
P36578	S87	Sugiyama	RPL4 RPL1	WGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAPTKT
P36578	T287	Sugiyama	RPL4 RPL1	WRKAAsLKsNyNLPMHKMINtDLsRILKsPEIQRALRAPRK
P36578	T69	Sugiyama	RPL4 RPL1	RQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGGGtHRsGQ
P37802	S163	Sugiyama	TAGLN2 KIAA0120 CDABP0035	LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802	T180	Sugiyama	TAGLN2 KIAA0120 CDABP0035	RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P37802	T190	Sugiyama	TAGLN2 KIAA0120 CDABP0035	GKNVIGLQMGtNRGAsQAGMtGyGMPRQIL___________
P38646	T398	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P38646	T94	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	QAKVLENAEGARttPsVVAFtADGERLVGMPAKRQAVtNPN
P39019	T55	Sugiyama	RPS19	DtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGsM
P39019	Y54	Sugiyama	RPS19	VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P41091	T115	Sugiyama	EIF2S3 EIF2G	SCPRPECyRSCGsstPDEFPtDIPGtKGNFKLVRHVSFVDC
P41567	T45	Sugiyama	EIF1 SUI1	AGTEDyIHIRIQQRNGRKtLttVQGIADDyDKKKLVKAFKK
P43487	S60	Sugiyama	RANBP1	TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46087	T409	Sugiyama	NOP2 NOL1 NSUN1	LDMCCAPGGKTSYMAQLMKNtGVILANDANAERLKSVVGNL
P46776	T95	Sugiyama	RPL27A	LDKLWtLVsEQtRVNAAKNKtGAAPIIDVVRsGyyKVLGKG
P46778	T29	Sugiyama	RPL21	RGTRYMFSRPFRKHGVVPLAtyMRIYKKGDIVDIKGMGTVQ
P48741	T47	Sugiyama	HSPA7 HSP70B	RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P49711	T374	Sugiyama	CTCF	SMCDYASVEVSKLKRHIRSHtGERPFQCSLCSYASRDTYKL
P49840	Y279	Sugiyama	GSK3A	LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P49841	Y216	Sugiyama	GSK3B	LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P50990	T286	Sugiyama	CCT8 C21orf112 CCTQ KIAA0002	MNFsKGEENLMDAQVKAIADtGANVVVtGGKVADMALHYAN
P50990	T293	Sugiyama	CCT8 C21orf112 CCTQ KIAA0002	ENLMDAQVKAIADtGANVVVtGGKVADMALHYANKYNIMLV
P50991	T50	Sugiyama	CCT4 CCTD SRB	PAQIRFsNISAAKAVADAIRtsLGPKGMDKMIQDGKGDVtI
P52209	S126	Sugiyama	PGD PGDH	YRDTTRRCRDLKAKGILFVGsGVsGGEEGARyGPSLMPGGN
P52747	T352	Sugiyama	ZNF143 SBF STAF	EGCGRSFTTSNIRKVHVRTHtGERPYyCTEPGCGRAFASAT
P52747	Y358	Sugiyama	ZNF143 SBF STAF	FTTSNIRKVHVRTHtGERPYyCTEPGCGRAFASATNYKNHV
P54652	T225	Sugiyama	HSPA2	GGTFDVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLA
P54652	T46	Sugiyama	HSPA2	KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTN
P55072	T249	Sugiyama	VCP HEL-220 HEL-S-70	LFKAIGVKPPRGILLyGPPGtGKTLIARAVANETGAFFFLI
P55795	S269	Sugiyama	HNRNPH2 FTP3 HNRPH2	YNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGssFQstTGH
P56270	S302	Sugiyama	MAZ ZNF801	EMCGKAFRDVYHLNRHKLSHsDEKPyQCPVCQQRFKRKDRM
P57721	S158	Sugiyama	PCBP3 PCBP3-OT1 PCBP3OT	AsQCGsLIGKGGSKIKEIREstGAQVQVAGDMLPNstERAV
P60174	S212	Sugiyama	TPI1 TPI	WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60174	T173	Sugiyama	TPI1 TPI	DNVKDWSKVVLAyEPVWAIGtGKtATPQQAQEVHEKLRGWL
P60174	T214	Sugiyama	TPI1 TPI	KsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGG
P60174	T38	Sugiyama	TPI1 TPI	RKQsLGELIGtLNAAKVPADtEVVCAPPtAyIDFARQKLDP
P60174	T46	Sugiyama	TPI1 TPI	IGtLNAAKVPADtEVVCAPPtAyIDFARQKLDPKIAVAAQN
P60484	S380	SIGNOR	PTEN MMAC1 TEP1	SSsTSVtPDVsDNEPDHyRYsDttDsDPENEPFDEDQHtQI
P60709	T318	Sugiyama	ACTB	VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P60891	S8	Sugiyama	PRPS1	_____________MPNIKIFsGssHQDLSQKIADRLGLELG
P61254	S31	Sugiyama	RPL26	RsKNRKRHFNAPsHIRRKIMssPLSKELRQKYNVRSMPIRK
P61254	T8	Sugiyama	RPL26	_____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P61604	T45	Sugiyama	HSPE1	TVTKGGIMLPEKSQGKVLQAtVVAVGsGsKGKGGEIQPVsV
P62191	T230	Sugiyama	PSMC1	yyEEMGIKPPKGVILyGPPGtGKTLLAKAVANQTsATFLRV
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62263	S137	Sugiyama	RPS14 PRO2640	RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62263	T133	Sugiyama	RPS14 PRO2640	QsALRALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL__
P62266	T34	Sugiyama	RPS23	RSHRRDQKWHDKQYKKAHLGtALKANPFGGAsHAKGIVLEK
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280	T15	Sugiyama	RPS11	______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62280	T28	Sugiyama	RPS11	RAyQKQPtIFQNKKRVLLGEtGKEKLPRYYKNIGLGFKtPK
P62280	T54	Sugiyama	RPS11	PRYYKNIGLGFKtPKEAIEGtyIDKKCPFTGNVsIRGRILs
P62424	T84	Sugiyama	RPL7A SURF-3 SURF3	QRQRAILyKRLKVPPAINQFtQALDRQTAtQLLKLAHKYRP
P62736	T320	Sugiyama	ACTA2 ACTSA ACTVS GIG46	VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P62750	T42	Sugiyama	RPL23A	LKAKKAVLKGVHSHKKKKIRtsPTFRRPKTLRLRRQPKYPR
P62753	T34	Sugiyama	RPS6 OK/SW-cl.2	KLIEVDDERKLRtFyEKRMAtEVAADALGEEWKGYVVRIsG
P62826	T21	Sugiyama	RAN ARA24 OK/SW-cl.81	MAAQGEPQVQFKLVLVGDGGtGKttFVKRHLtGEFEKKyVA
P62826	T32	Sugiyama	RAN ARA24 OK/SW-cl.81	KLVLVGDGGtGKttFVKRHLtGEFEKKyVATLGVEVHPLVF
P62826	T66	Sugiyama	RAN ARA24 OK/SW-cl.81	EVHPLVFHTNRGPIKFNVWDtAGQEKFGGLRDGYYIQAQCA
P62857	T21	Sugiyama	RPS28	MDTSRVQPIKLARVTKVLGRtGsQGQCtQVRVEFMDDtsRs
P62917	T135	Sugiyama	RPL8	CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917	T146	Sugiyama	RPL8	LARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVISSANRAVV
P62937	T157	Sugiyama	PPIA CYPA	NIVEAMERFGsRNGKTSKKItIADCGQLE____________
P62942	T22	Sugiyama	FKBP1A FKBP1 FKBP12	GVQVEtIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRD
P62942	T28	Sugiyama	FKBP1A FKBP1 FKBP12	IsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRDRNKPFK
P62942	T7	Sugiyama	FKBP1A FKBP1 FKBP12	______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P62979	S123	Sugiyama	RPS27A UBA80 UBCEP1	LKYYKVDENGKIsRLRRECPsDECGAGVFMAsHFDRHyCGK
P63173	T14	Sugiyama	RPL38	_______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63173	T44	Sugiyama	RPL38	KIKKNKDNVKFKVRCSRyLytLVItDKEKAEKLKQSLPPGL
P63173	T48	Sugiyama	RPL38	NKDNVKFKVRCSRyLytLVItDKEKAEKLKQSLPPGLAVKE
P63261	T318	Sugiyama	ACTG1 ACTG	VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P63267	T319	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P67809	S209	Sugiyama	YBX1 NSEP1 YB1	RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P67809	T126	Sugiyama	YBX1 NSEP1 YB1	GEtVEFDVVEGEKGAEAANVtGPGGVPVQGsKYAADRNHYR
P67809	T89	Sugiyama	YBX1 NSEP1 YB1	RNGyGFINRNDtKEDVFVHQtAIKKNNPRKyLRsVGDGEtV
P68032	T320	Sugiyama	ACTC1 ACTC	VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68104	T432	Sugiyama	EEF1A1 EEF1A EF1A LENG7	VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133	T320	Sugiyama	ACTA1 ACTA	VMSGGTTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68363	T56	Sugiyama	TUBA1B	MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVID
P68363	T73	Sugiyama	TUBA1B	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363	Y83	Sugiyama	TUBA1B	PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
P68431	S11	SIGNOR\|EPSD	H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J	__________MARtKQtARKstGGKAPRKQLATKAARKsAP
P78371	T242	Sugiyama	CCT2 99D8.1 CCTB	KKIGVNQPKRIENAKILIANtGMDtDKIKIFGsRVRVDstA
P81274	T457	GPS6\|SIGNOR\|EPSD\|PSP	GPSM2 LGN	IAKPSAKLLFVNRLKGKKYKtNSSTKVLQDASNSIDHRIPN
P83731	T83	Sugiyama	RPL24	QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098	S12	Sugiyama	RPL19	_________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
P84098	T29	Sugiyama	RPL19	RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
Q00839	T549	Sugiyama	HNRNPU C1orf199 HNRPU SAFA U21.1	GtNtIMDKMMVAGFKKQMADtGKLNtLLQRAPQCLGKFIEI
Q00839	T554	Sugiyama	HNRNPU C1orf199 HNRPU SAFA U21.1	MDKMMVAGFKKQMADtGKLNtLLQRAPQCLGKFIEIAARKK
Q01105	S165	Sugiyama	SET	PyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQ
Q01105	T169	Sugiyama	SET	NKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQNK
Q02878	T118	Sugiyama	RPL6 TXREB1	GDKNGGTRVVKLRKMPRyyPtEDVPRKLLSHGKKPFSQHVR
Q02878	T213	Sugiyama	RPL6 TXREB1	FVIAtsTKIDISNVKIPKHLtDAyFKKKKLRKPRHQEGEIF
Q02878	T91	Sugiyama	RPL6 TXREB1	RKYSAAKSKVEKKKKEKVLAtVtKPVGGDKNGGTRVVKLRK
Q05639	T432	Sugiyama	EEF1A2 EEF1AL STN	VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q06830	S32	SIGNOR\|EPSD\|PSP	PRDX1 PAGA PAGB TDPX2	APNFKAtAVMPDGQFKDIsLsDyKGKYVVFFFYPLDFTFVC
Q06830	T166	Sugiyama	PRDX1 PAGA PAGB TDPX2	DLPVGRsVDEtLRLVQAFQFtDKHGEVCPAGWKPGsDtIKP
Q06830	T18	Sugiyama	PRDX1 PAGA PAGB TDPX2	___MSSGNAKIGHPAPNFKAtAVMPDGQFKDIsLsDyKGKY
Q07020	T85	Sugiyama	RPL18	RMIRKMKLPGRENKtAVVVGtItDDVRVQEVPKLKVCALRV
Q13310	T191	Sugiyama	PABPC4 APP1 PABP4	GRFKSRKEREAELGAKAKEFtNVyIKNFGEEVDDEsLKELF
Q13442	S19	Sugiyama	PDAP1 HASPP28	__MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEEE
Q13442	T18	Sugiyama	PDAP1 HASPP28	___MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEE
Q13642	T39	Sugiyama	FHL1 SLIM1	YVQKDGHHCCLKCFDKFCANtCVECRKPIGADSKEVHYKNR
Q14119	S197	Sugiyama	VEZF1 DB1 ZNF161	EMCGKAFRDVYHLNRHKLSHsDEKPFECPICNQRFKRKDRM
Q14152	T1372	Sugiyama	EIF3A EIF3S10 KIAA0139	EKASWRAEKDREsLRRTKNEtDEDGWttVRR__________
Q14592	S275	Sugiyama	ZNF460 ZNF272	SECGRTFNRGSHLTRHQRVHsGEKPFVCNECGKAFTYRSNF
Q15080	S67	Sugiyama	NCF4 SH3PXD4	TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15365	S126	Sugiyama	PCBP1	ATQCGsLIGKGGCKIKEIREstGAQVQVAGDMLPNstERAI
Q15366	S126	Sugiyama	PCBP2	AsQCGsLIGKGGCKIKEIREstGAQVQVAGDMLPNstERAI
Q16881	T311	Sugiyama	TXNRD1 GRIM12 KDRF	KATNNKGKEKIYSAERFLIAtGERPRyLGIPGDKEyCIsSD
Q562R1	T107	Sugiyama	ACTBL2	WYHTFYNELRVAPDEHPILLtEAPLNPKINREKMTQIMFEA
Q5VTE0	T432	Sugiyama	EEF1A1P5 EEF1AL3	VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q6PEY2	T56	Sugiyama	TUBA3E	MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVVD
Q6PKG0	T747	Sugiyama	LARP1 KIAA0731 LARP	PPVDPNQEVPPGPPRFQQVPtDALANKLFGAPEPstIARsL
Q6QNY0	T16	Sugiyama	BLOC1S3 BLOS3	_____MASQGRRRRPLRRPEtVVPGEAtEtDsERsAsssEE
Q6ZMR3	S161	Sugiyama	LDHAL6A LDHL2	DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q71U36	T56	Sugiyama	TUBA1A TUBA3	MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVID
Q71U36	T73	Sugiyama	TUBA1A TUBA3	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36	Y83	Sugiyama	TUBA1A TUBA3	PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q8IWL2	S16	Sugiyama	SFTPA1 COLEC4 PSAP SFTP1 SFTPA SFTPA1B	_____MWLCPLALNLILMAAsGAVCEVKDVCVGSPGIPGTP
Q8IZP0	T114	Sugiyama	ABI1 SSH3BP1	SQTVDIHKEKVARREIGILTtNKNTSRTHKIIAPANMERPV
Q8N1G4	T27	Sugiyama	LRRC47 KIAA1185	SESWPELELAERERRRELLLtGPGLEERVRAAGGQLPPRLF
Q8NBJ7	T260	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	SPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMGNtPD
Q8TEQ6	S847	Sugiyama	GEMIN5	LKKEPPKEKPETLIKKRKARsLLPLstsLDHRSKEELHQDC
Q8TEQ6	S852	Sugiyama	GEMIN5	PKEKPETLIKKRKARsLLPLstsLDHRSKEELHQDCLVLAT
Q8WU90	T345	Sugiyama	ZC3H15 DFRP1 LEREPO4 HSPC303 HT010 MSTP012 PP730	DsVsVNDIDLSLYIPRDVDEtGItVAsLERFSTYTsDKDEN
Q8WVC0	T477	Sugiyama	LEO1 RDL	FDVYKAPLQGDHNHLFIRQGtGLQGQAVFKTKLTFRPHstD
Q96KB5	S110	Sugiyama	PBK TOPK	KsLHHPNIVGyRAFtEANDGsLCLAMEYGGEKSLNDLIEER
Q96KB5	S19	Sugiyama	PBK TOPK	__MEGISNFKtPsKLsEKKKsVLCstPtINIPAsPFMQKLG
Q96KB5	S32	Sugiyama	PBK TOPK	KLsEKKKsVLCstPtINIPAsPFMQKLGFGTGVNVYLMKRS
Q96KB5	S59	Sugiyama	PBK TOPK	GFGTGVNVYLMKRSPRGLsHsPWAVKKINPICNDHyRsVYQ
Q96KB5	T104	Sugiyama	PBK TOPK	DEAKILKsLHHPNIVGyRAFtEANDGsLCLAMEYGGEKSLN
Q96KB5	T24	Sugiyama	PBK TOPK	ISNFKtPsKLsEKKKsVLCstPtINIPAsPFMQKLGFGTGV
Q96KB5	T301	Sugiyama	PBK TOPK	INMEELDESYQKVIELFsVCtNEDPKDRPsAAHIVEALEtD
Q96KB5	T320	Sugiyama	PBK TOPK	CtNEDPKDRPsAAHIVEALEtDV__________________
Q96S44	S250	EPSD\|PSP	TP53RK C20orf64 PRPK	KKARPVLKKLDEVRLRGRKRsMVG_________________
Q9BQE3	T56	Sugiyama	TUBA1C TUBA6	MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVID
Q9BQE3	T73	Sugiyama	TUBA1C TUBA6	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3	Y83	Sugiyama	TUBA1C TUBA6	PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q9BUJ2	T507	Sugiyama	HNRNPUL1 E1BAP5 HNRPUL1	CLNRLIQIAARKKRNyILDQtNVyGsAQRRKMRPFEGFQRK
Q9BX40	T343	Sugiyama	LSM14B C20orf40 FAM61B RAP55B	ssELKTSSRRTTWAEERKLNtEtFGVsGRFLRGRSSRGGFR
Q9BX95	S112	Sugiyama	SGPP1 SPP1	GLAAELGPAsPRRAGALRRNsLtGEEGQLARVSNWPLYCLF
Q9BYW2	T1316	Sugiyama	SETD2 HIF1 HYPB KIAA1732 KMT3A SET2 HSPC069	TRDYWQGNGYWDPRSGRPPGtGVVYDRTQGQVPDSLTDDRE
Q9NVS9	T111	Sugiyama	PNPO	KPSARMLLLKGFGKDGFRFFtNFESRKGKELDSNPFASLVF
Q9NVS9	T238	Sugiyama	PNPO	FWQGQTNRLHDRIVFRRGLPtGDsPLGPMTHRGEEDWLyER
Q9NYB9	T114	Sugiyama	ABI2 ARGBPIA	SQTVDIHKEKVARREIGILTtNKNTSRTHKIIAPANLERPV
Q9UI15	T190	Sugiyama	TAGLN3 NP25	GQNVIGLQMGSNKGAsQAGMtGyGMPRQIM___________
Q9UKX7	T54	Sugiyama	NUP50 NPAP60L PRO1146	VLKNRAIKKAKRRNVGFEsDtGGAFKGFKGLVVPSGGGRFs
Q9ULF5	T87	Sugiyama	SLC39A10 KIAA1265 ZIP10	LFERYGENGRLSFFGLEKLLtNLGLGERKVVEINHEDLGHD
Q9UNX3	S31	Sugiyama	RPL26L1 RPL26P1	RsKNRKRHFNAPSHVRRKIMssPLSKELRQKYNVRSMPIRK
Q9UNX3	T8	Sugiyama	RPL26L1 RPL26P1	_____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Q9UQ80	T377	Sugiyama	PA2G4 EBP1	LLQssAsRKtQKKKKKKAsKtAENAtsGEtLEENEAGD___
Q9Y2T7	T124	Sugiyama	YBX2 CSDA3 MSY2	RNGyGFINRNDtKEDVFVHQtAIKRNNPRKFLRsVGDGEtV

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
RNA Polymerase II Transcription	R-HSA-73857	1.049735e-09	8.979
Generic Transcription Pathway	R-HSA-212436	8.733220e-10	9.059
Gene expression (Transcription)	R-HSA-74160	1.110223e-08	7.955
Axon guidance	R-HSA-422475	2.235945e-06	5.651
Nervous system development	R-HSA-9675108	5.321189e-06	5.274
Apoptotic execution phase	R-HSA-75153	1.412335e-05	4.850
Signaling by ROBO receptors	R-HSA-376176	3.894988e-05	4.409
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	4.783421e-05	4.320
Activation of AMPK downstream of NMDARs	R-HSA-9619483	7.783768e-05	4.109
Cellular responses to stress	R-HSA-2262752	6.842284e-05	4.165
Cellular responses to stimuli	R-HSA-8953897	7.958815e-05	4.099
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	7.944881e-05	4.100
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	1.203957e-04	3.919
MHC class II antigen presentation	R-HSA-2132295	1.537755e-04	3.813
Apoptosis induced DNA fragmentation	R-HSA-140342	1.919417e-04	3.717
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	2.275440e-04	3.643
Translation initiation complex formation	R-HSA-72649	2.265778e-04	3.645
Eukaryotic Translation Elongation	R-HSA-156842	2.757518e-04	3.559
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	2.806882e-04	3.552
Ribosomal scanning and start codon recognition	R-HSA-72702	2.903818e-04	3.537
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	3.615185e-04	3.442
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	3.685531e-04	3.433
Transport of connexons to the plasma membrane	R-HSA-190872	3.545847e-04	3.450
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	4.084795e-04	3.389
Recycling pathway of L1	R-HSA-437239	4.153905e-04	3.382
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	4.253370e-04	3.371
Cell junction organization	R-HSA-446728	4.564797e-04	3.341
Post-chaperonin tubulin folding pathway	R-HSA-389977	5.474646e-04	3.262
Peptide chain elongation	R-HSA-156902	6.044902e-04	3.219
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	6.452993e-04	3.190
Aggrephagy	R-HSA-9646399	6.665942e-04	3.176
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	7.809628e-04	3.107
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	8.534352e-04	3.069
Apoptotic cleavage of cellular proteins	R-HSA-111465	9.102673e-04	3.041
mRNA Splicing - Major Pathway	R-HSA-72163	1.059979e-03	2.975
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.065182e-03	2.973
MTOR signalling	R-HSA-165159	9.877534e-04	3.005
Cell-extracellular matrix interactions	R-HSA-446353	1.055360e-03	2.977
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	9.603734e-04	3.018
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	1.071790e-03	2.970
SARS-CoV-1-host interactions	R-HSA-9692914	1.043642e-03	2.981
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	1.210416e-03	2.917
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	1.210416e-03	2.917
Separation of Sister Chromatids	R-HSA-2467813	1.176519e-03	2.929
Cell-Cell communication	R-HSA-1500931	1.126642e-03	2.948
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.169404e-03	2.932
EPHB-mediated forward signaling	R-HSA-3928662	1.263265e-03	2.899
Mitotic Anaphase	R-HSA-68882	1.448339e-03	2.839
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	1.501403e-03	2.824
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.520688e-03	2.818
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	1.596722e-03	2.797
mRNA Splicing	R-HSA-72172	1.862050e-03	2.730
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	1.851512e-03	2.732
Transcriptional activation of p53 responsive genes	R-HSA-69560	1.851512e-03	2.732
Regulation of PTEN gene transcription	R-HSA-8943724	1.796294e-03	2.746
Mitotic G2-G2/M phases	R-HSA-453274	1.862701e-03	2.730
Kinesins	R-HSA-983189	1.796294e-03	2.746
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	2.177858e-03	2.662
Cap-dependent Translation Initiation	R-HSA-72737	2.413011e-03	2.617
Eukaryotic Translation Initiation	R-HSA-72613	2.413011e-03	2.617
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	2.485534e-03	2.605
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	2.491476e-03	2.604
Metabolism of RNA	R-HSA-8953854	2.690866e-03	2.570
Influenza Infection	R-HSA-168255	2.790278e-03	2.554
Regulation of CDH11 Expression and Function	R-HSA-9759475	2.969081e-03	2.527
Cellular Senescence	R-HSA-2559583	2.933772e-03	2.533
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	3.063498e-03	2.514
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	3.584362e-03	2.446
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	3.739454e-03	2.427
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	3.721270e-03	2.429
Formation of a pool of free 40S subunits	R-HSA-72689	3.843134e-03	2.415
Eukaryotic Translation Termination	R-HSA-72764	3.843134e-03	2.415
AKT phosphorylates targets in the cytosol	R-HSA-198323	4.003780e-03	2.398
G2/M Transition	R-HSA-69275	3.929288e-03	2.406
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	4.173955e-03	2.379
Nonsense-Mediated Decay (NMD)	R-HSA-927802	4.489025e-03	2.348
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	4.489025e-03	2.348
Influenza Viral RNA Transcription and Replication	R-HSA-168273	4.398455e-03	2.357
Autophagy	R-HSA-9612973	4.629781e-03	2.334
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	4.988049e-03	2.302
Gap junction trafficking	R-HSA-190828	5.131394e-03	2.290
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	4.856689e-03	2.314
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	4.988049e-03	2.302
SARS-CoV-1 Infection	R-HSA-9678108	5.312605e-03	2.275
Mitotic Prometaphase	R-HSA-68877	5.426538e-03	2.265
mTORC1-mediated signalling	R-HSA-166208	5.503817e-03	2.259
Post NMDA receptor activation events	R-HSA-438064	5.558607e-03	2.255
Selenocysteine synthesis	R-HSA-2408557	5.725192e-03	2.242
Selective autophagy	R-HSA-9663891	5.958109e-03	2.225
Gap junction assembly	R-HSA-190861	6.309345e-03	2.200
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	6.354426e-03	2.197
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	6.480357e-03	2.188
Viral mRNA Translation	R-HSA-192823	6.492560e-03	2.188
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	7.429494e-03	2.129
Semaphorin interactions	R-HSA-373755	8.048164e-03	2.094
Gap junction trafficking and regulation	R-HSA-157858	8.269950e-03	2.082
EPH-Ephrin signaling	R-HSA-2682334	8.301992e-03	2.081
PIP3 activates AKT signaling	R-HSA-1257604	8.315778e-03	2.080
Sema4D in semaphorin signaling	R-HSA-400685	8.324648e-03	2.080
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	8.647357e-03	2.063
Type I hemidesmosome assembly	R-HSA-446107	9.869738e-03	2.006
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.485646e-03	2.023
PKR-mediated signaling	R-HSA-9833482	9.267544e-03	2.033
Ribosome-associated quality control	R-HSA-9948299	9.928593e-03	2.003
Macroautophagy	R-HSA-1632852	1.147828e-02	1.940
ALK mutants bind TKIs	R-HSA-9700645	1.244976e-02	1.905
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.244976e-02	1.905
Chromatin organization	R-HSA-4839726	1.216576e-02	1.915
Signaling by Hippo	R-HSA-2028269	1.191128e-02	1.924
Cellular response to starvation	R-HSA-9711097	1.168659e-02	1.932
Regulation of CDH11 gene transcription	R-HSA-9762293	1.244976e-02	1.905
Regulation of TP53 Activity	R-HSA-5633007	1.276785e-02	1.894
FOXO-mediated transcription	R-HSA-9614085	1.345036e-02	1.871
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.351540e-02	1.869
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.538025e-02	1.813
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	1.589719e-02	1.799
Cell Cycle	R-HSA-1640170	1.632878e-02	1.787
Golgi-to-ER retrograde transport	R-HSA-8856688	1.636104e-02	1.786
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	1.643438e-02	1.784
MET interacts with TNS proteins	R-HSA-8875513	1.709213e-02	1.767
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.813154e-02	1.742
Cell Cycle Checkpoints	R-HSA-69620	1.653233e-02	1.782
Creatine metabolism	R-HSA-71288	1.813154e-02	1.742
ISG15 antiviral mechanism	R-HSA-1169408	1.881215e-02	1.726
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	2.339138e-02	1.631
Nuclear Receptor transcription pathway	R-HSA-383280	2.262367e-02	1.645
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	2.398641e-02	1.620
PCP/CE pathway	R-HSA-4086400	2.262367e-02	1.645
PTEN Regulation	R-HSA-6807070	2.337592e-02	1.631
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	2.231103e-02	1.651
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	2.265132e-02	1.645
Regulation of CDH1 Expression and Function	R-HSA-9764265	2.265132e-02	1.645
Dopamine receptors	R-HSA-390651	2.398641e-02	1.620
SARS-CoV-2-host interactions	R-HSA-9705683	2.194795e-02	1.659
G1/S DNA Damage Checkpoints	R-HSA-69615	2.429371e-02	1.615
FGFR2 alternative splicing	R-HSA-6803529	2.605538e-02	1.584
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	2.631496e-02	1.580
HCMV Early Events	R-HSA-9609690	2.634737e-02	1.579
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	2.634737e-02	1.579
Chromatin modifying enzymes	R-HSA-3247509	2.670071e-02	1.573
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	2.688600e-02	1.570
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	2.841877e-02	1.546
COPI-mediated anterograde transport	R-HSA-6807878	2.841877e-02	1.546
Apoptosis	R-HSA-109581	2.921412e-02	1.534
Deadenylation of mRNA	R-HSA-429947	3.232817e-02	1.490
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	3.323553e-02	1.478
M Phase	R-HSA-68886	3.308161e-02	1.480
Intracellular signaling by second messengers	R-HSA-9006925	3.328844e-02	1.478
Regulation of MITF-M dependent genes involved in invasion	R-HSA-9854909	3.182025e-02	1.497
Transcriptional Regulation by TP53	R-HSA-3700989	3.257062e-02	1.487
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	3.457021e-02	1.461
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	3.537845e-02	1.451
Amplification of signal from the kinetochores	R-HSA-141424	3.537845e-02	1.451
Signal Transduction	R-HSA-162582	3.538686e-02	1.451
Golgi Associated Vesicle Biogenesis	R-HSA-432722	3.593288e-02	1.445
L1CAM interactions	R-HSA-373760	3.634116e-02	1.440
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	3.872714e-02	1.412
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	4.051076e-02	1.392
IkBA variant leads to EDA-ID	R-HSA-5603029	4.051076e-02	1.392
Sema3A PAK dependent Axon repulsion	R-HSA-399954	4.046306e-02	1.393
p75NTR signals via NF-kB	R-HSA-193639	4.046306e-02	1.393
Chaperonin-mediated protein folding	R-HSA-390466	3.919893e-02	1.407
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	4.348691e-02	1.362
trans-Golgi Network Vesicle Budding	R-HSA-199992	4.179558e-02	1.379
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	4.051076e-02	1.392
Cell Cycle, Mitotic	R-HSA-69278	4.437492e-02	1.353
Cell-cell junction organization	R-HSA-421270	4.433988e-02	1.353
PKMTs methylate histone lysines	R-HSA-3214841	4.348691e-02	1.362
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	4.413919e-02	1.355
Cargo trafficking to the periciliary membrane	R-HSA-5620920	3.953426e-02	1.403
rRNA processing	R-HSA-72312	4.578220e-02	1.339
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	4.783623e-02	1.320
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	4.959912e-02	1.305
Signaling by ALK in cancer	R-HSA-9700206	4.959912e-02	1.305
Regulation of NFE2L2 gene expression	R-HSA-9818749	4.998006e-02	1.301
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	5.162948e-02	1.287
Protein folding	R-HSA-391251	5.227903e-02	1.282
Adherens junctions interactions	R-HSA-418990	5.454087e-02	1.263
Interferon Signaling	R-HSA-913531	5.457244e-02	1.263
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	5.520172e-02	1.258
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	5.601560e-02	1.252
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	6.015500e-02	1.221
MECP2 regulates transcription factors	R-HSA-9022707	6.015500e-02	1.221
Signaling by NTRK1 (TRKA)	R-HSA-187037	6.096344e-02	1.215
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	7.096690e-02	1.149
FGFR1b ligand binding and activation	R-HSA-190370	7.096690e-02	1.149
Signaling by TGFBR3	R-HSA-9839373	6.510561e-02	1.186
Transcriptional regulation by RUNX3	R-HSA-8878159	6.787873e-02	1.168
FOXO-mediated transcription of cell death genes	R-HSA-9614657	6.411769e-02	1.193
Developmental Biology	R-HSA-1266738	6.338207e-02	1.198
Interleukin-18 signaling	R-HSA-9012546	7.096690e-02	1.149
Polo-like kinase mediated events	R-HSA-156711	6.411769e-02	1.193
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	7.215552e-02	1.142
SARS-CoV-2 Infection	R-HSA-9694516	6.415464e-02	1.193
Intraflagellar transport	R-HSA-5620924	7.343422e-02	1.134
p75 NTR receptor-mediated signalling	R-HSA-193704	7.365147e-02	1.133
HCMV Infection	R-HSA-9609646	7.404572e-02	1.131
Diseases of Telomere Maintenance	R-HSA-9673013	7.595675e-02	1.119
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	7.595675e-02	1.119
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	7.595675e-02	1.119
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	7.595675e-02	1.119
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	7.595675e-02	1.119
IKBKB deficiency causes SCID	R-HSA-5602636	1.117467e-01	0.952
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	R-HSA-5603027	1.117467e-01	0.952
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	1.117467e-01	0.952
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	1.792276e-01	0.747
Axonal growth stimulation	R-HSA-209563	1.792276e-01	0.747
WNT mediated activation of DVL	R-HSA-201688	8.235136e-02	1.084
MTF1 activates gene expression	R-HSA-5660489	2.110234e-01	0.676
Inhibition of TSC complex formation by PKB	R-HSA-165181	2.110234e-01	0.676
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	2.110234e-01	0.676
GRB7 events in ERBB2 signaling	R-HSA-1306955	2.110234e-01	0.676
PI3K/AKT activation	R-HSA-198203	9.424795e-02	1.026
Signaling by APC mutants	R-HSA-4839744	1.066001e-01	0.972
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.066001e-01	0.972
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.066001e-01	0.972
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.066001e-01	0.972
IRS activation	R-HSA-74713	2.415894e-01	0.617
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	2.415894e-01	0.617
G2 Phase	R-HSA-68911	2.415894e-01	0.617
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.415894e-01	0.617
Signaling by GSK3beta mutants	R-HSA-5339716	1.193548e-01	0.923
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	1.324624e-01	0.878
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	1.324624e-01	0.878
IRAK1 recruits IKK complex	R-HSA-937039	1.324624e-01	0.878
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	1.324624e-01	0.878
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	1.324624e-01	0.878
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	1.324624e-01	0.878
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	1.324624e-01	0.878
Plus-strand DNA synthesis	R-HSA-164525	2.709730e-01	0.567
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	2.709730e-01	0.567
Loss-of-function mutations in DBT cause MSUD2	R-HSA-9865113	2.709730e-01	0.567
Loss-of-function mutations in DLD cause MSUD3/DLDD	R-HSA-9907570	2.709730e-01	0.567
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	7.785431e-02	1.109
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	1.458767e-01	0.836
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	1.458767e-01	0.836
Retrograde neurotrophin signalling	R-HSA-177504	1.595543e-01	0.797
Uncoating of the HIV Virion	R-HSA-162585	2.992199e-01	0.524
H139Hfs13* PPM1K causes a mild variant of MSUD	R-HSA-9912529	2.992199e-01	0.524
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	2.992199e-01	0.524
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	2.992199e-01	0.524
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	1.734548e-01	0.761
Beta-catenin phosphorylation cascade	R-HSA-196299	1.734548e-01	0.761
Striated Muscle Contraction	R-HSA-390522	7.581885e-02	1.120
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	3.263740e-01	0.486
SOS-mediated signalling	R-HSA-112412	3.263740e-01	0.486
Cohesin Loading onto Chromatin	R-HSA-2470946	3.263740e-01	0.486
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	3.263740e-01	0.486
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	2.017762e-01	0.695
Reverse Transcription of HIV RNA	R-HSA-162589	3.524775e-01	0.453
Minus-strand DNA synthesis	R-HSA-164516	3.524775e-01	0.453
RSK activation	R-HSA-444257	3.524775e-01	0.453
Regulation of NPAS4 mRNA translation	R-HSA-9768778	3.524775e-01	0.453
Signaling by MRAS-complex mutants	R-HSA-9660537	3.524775e-01	0.453
Formation of annular gap junctions	R-HSA-196025	3.524775e-01	0.453
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	3.524775e-01	0.453
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.716482e-01	0.765
Signaling by FGFR2 IIIa TM	R-HSA-8851708	2.450684e-01	0.611
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	3.775710e-01	0.423
Gap junction degradation	R-HSA-190873	3.775710e-01	0.423
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.813601e-01	0.741
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.813601e-01	0.741
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	1.380716e-01	0.860
IPs transport between nucleus and cytosol	R-HSA-1855170	2.012019e-01	0.696
Transport of the SLBP independent Mature mRNA	R-HSA-159227	2.012019e-01	0.696
Binding and entry of HIV virion	R-HSA-173107	4.016935e-01	0.396
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	4.016935e-01	0.396
OADH complex synthesizes glutaryl-CoA from 2-OA	R-HSA-9858328	4.016935e-01	0.396
Folding of actin by CCT/TriC	R-HSA-390450	4.016935e-01	0.396
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	2.113078e-01	0.675
snRNP Assembly	R-HSA-191859	1.287835e-01	0.890
Metabolism of non-coding RNA	R-HSA-194441	1.287835e-01	0.890
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	2.318311e-01	0.635
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	3.031571e-01	0.518
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	3.031571e-01	0.518
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	3.031571e-01	0.518
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	4.248825e-01	0.372
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	2.422259e-01	0.616
Regulation of RAS by GAPs	R-HSA-5658442	1.985158e-01	0.702
mRNA 3'-end processing	R-HSA-72187	2.147332e-01	0.668
Condensation of Prometaphase Chromosomes	R-HSA-2514853	4.471742e-01	0.350
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	4.471742e-01	0.350
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	2.738124e-01	0.563
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	1.980833e-01	0.703
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	2.844408e-01	0.546
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	2.844408e-01	0.546
MET activates PTK2 signaling	R-HSA-8874081	3.604160e-01	0.443
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	2.188767e-01	0.660
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	3.057882e-01	0.515
HIV Transcription Initiation	R-HSA-167161	3.057882e-01	0.515
RNA Polymerase II Transcription Initiation	R-HSA-75953	3.057882e-01	0.515
RNA Polymerase II Promoter Escape	R-HSA-73776	3.271954e-01	0.485
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	4.022033e-01	0.396
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	3.485937e-01	0.458
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	3.088999e-01	0.510
Loss of Nlp from mitotic centrosomes	R-HSA-380259	3.088999e-01	0.510
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	2.846678e-01	0.546
AURKA Activation by TPX2	R-HSA-8854518	3.354119e-01	0.474
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	3.227156e-01	0.491
Developmental Lineages of the Mammary Gland	R-HSA-9924644	3.885776e-01	0.411
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	3.974037e-01	0.401
Centrosome maturation	R-HSA-380287	4.149883e-01	0.382
RNA Polymerase III Transcription	R-HSA-74158	2.422259e-01	0.616
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	1.598057e-01	0.796
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	1.598057e-01	0.796
Neutrophil degranulation	R-HSA-6798695	3.409132e-01	0.467
p75NTR recruits signalling complexes	R-HSA-209543	1.324624e-01	0.878
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	3.535466e-01	0.452
Regulation of endogenous retroelements	R-HSA-9842860	2.904426e-01	0.537
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	2.049380e-01	0.688
G0 and Early G1	R-HSA-1538133	1.912153e-01	0.718
RNA Polymerase III Transcription Initiation	R-HSA-76046	1.716482e-01	0.765
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	4.076763e-01	0.390
Signaling by FGFR	R-HSA-190236	1.441223e-01	0.841
RET signaling	R-HSA-8853659	2.422259e-01	0.616
Regulation of CDH11 function	R-HSA-9762292	9.424795e-02	1.026
Processing of Intronless Pre-mRNAs	R-HSA-77595	2.017762e-01	0.695
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	4.248825e-01	0.372
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	1.598057e-01	0.796
Signaling by FGFR2	R-HSA-5654738	1.386348e-01	0.858
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	8.235136e-02	1.084
NF-kB is activated and signals survival	R-HSA-209560	1.193548e-01	0.923
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.193548e-01	0.923
Serotonin clearance from the synaptic cleft	R-HSA-380615	1.324624e-01	0.878
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	1.734548e-01	0.761
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	1.875404e-01	0.727
TGFBR3 expression	R-HSA-9839394	1.256750e-01	0.901
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	2.017762e-01	0.695
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	9.267766e-02	1.033
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	3.524775e-01	0.453
MET promotes cell motility	R-HSA-8875878	1.048193e-01	0.980
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	1.176429e-01	0.929
TRAF6 mediated NF-kB activation	R-HSA-933542	3.319608e-01	0.479
Budding and maturation of HIV virion	R-HSA-162588	4.293337e-01	0.367
Signaling by FLT3 fusion proteins	R-HSA-9703465	1.344829e-01	0.871
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	1.434969e-01	0.843
Asymmetric localization of PCP proteins	R-HSA-4608870	1.598057e-01	0.796
RNA Polymerase I Transcription	R-HSA-73864	2.548922e-01	0.594
G1 Phase	R-HSA-69236	1.524251e-01	0.817
Cyclin D associated events in G1	R-HSA-69231	1.524251e-01	0.817
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	3.699196e-01	0.432
Activation of NF-kappaB in B cells	R-HSA-1169091	2.065780e-01	0.685
RNA Polymerase I Promoter Clearance	R-HSA-73854	2.403037e-01	0.619
Late Phase of HIV Life Cycle	R-HSA-162599	3.005359e-01	0.522
HIV Life Cycle	R-HSA-162587	3.880665e-01	0.411
Formation of the posterior neural plate	R-HSA-9832991	1.066001e-01	0.972
Post-transcriptional silencing by small RNAs	R-HSA-426496	2.415894e-01	0.617
FGFR1c ligand binding and activation	R-HSA-190373	1.458767e-01	0.836
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	1.875404e-01	0.727
Killing mechanisms	R-HSA-9664420	1.875404e-01	0.727
PTK6 Expression	R-HSA-8849473	3.263740e-01	0.486
RNA Polymerase I Transcription Initiation	R-HSA-73762	1.380716e-01	0.860
FGFR2b ligand binding and activation	R-HSA-190377	4.248825e-01	0.372
Sensing of DNA Double Strand Breaks	R-HSA-5693548	4.471742e-01	0.350
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	4.471742e-01	0.350
Meiotic synapsis	R-HSA-1221632	2.229753e-01	0.652
Tight junction interactions	R-HSA-420029	3.462395e-01	0.461
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	2.951025e-01	0.530
Nuclear events mediated by NFE2L2	R-HSA-9759194	2.873463e-01	0.542
Lysosome Vesicle Biogenesis	R-HSA-432720	9.267766e-02	1.033
p75NTR regulates axonogenesis	R-HSA-193697	3.775710e-01	0.423
HSF1-dependent transactivation	R-HSA-3371571	2.065780e-01	0.685
Meiosis	R-HSA-1500620	3.074106e-01	0.512
Degradation of beta-catenin by the destruction complex	R-HSA-195253	3.708782e-01	0.431
IRF3-mediated induction of type I IFN	R-HSA-3270619	1.734548e-01	0.761
Diseases of mitotic cell cycle	R-HSA-9675126	1.912153e-01	0.718
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	3.604160e-01	0.443
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	3.744768e-01	0.427
CLEC7A (Dectin-1) signaling	R-HSA-5607764	4.153793e-01	0.382
FGFR1 ligand binding and activation	R-HSA-190242	2.305694e-01	0.637
Mitotic Spindle Checkpoint	R-HSA-69618	7.664594e-02	1.116
Degradation of DVL	R-HSA-4641258	2.526947e-01	0.597
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	4.471742e-01	0.350
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	3.378998e-01	0.471
HIV Infection	R-HSA-162906	3.861561e-01	0.413
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	2.118704e-01	0.674
Signaling by WNT in cancer	R-HSA-4791275	4.426531e-01	0.354
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	3.354119e-01	0.474
Proteasome assembly	R-HSA-9907900	3.378998e-01	0.471
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	2.846678e-01	0.546
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	1.980833e-01	0.703
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	1.003517e-01	0.998
KEAP1-NFE2L2 pathway	R-HSA-9755511	2.287322e-01	0.641
Inhibition of Host mRNA Processing and RNA Silencing	R-HSA-168315	1.117467e-01	0.952
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	1.461524e-01	0.835
STAT6-mediated induction of chemokines	R-HSA-3249367	1.792276e-01	0.747
Signaling by AXIN mutants	R-HSA-4839735	1.193548e-01	0.923
Signaling by AMER1 mutants	R-HSA-4839748	1.193548e-01	0.923
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	1.324624e-01	0.878
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	2.709730e-01	0.567
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	2.709730e-01	0.567
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	1.458767e-01	0.836
Fibronectin matrix formation	R-HSA-1566977	2.017762e-01	0.695
Axonal growth inhibition (RHOA activation)	R-HSA-193634	3.524775e-01	0.453
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	3.775710e-01	0.423
Cyclin E associated events during G1/S transition	R-HSA-69202	9.177323e-02	1.037
Metabolism of serotonin	R-HSA-380612	4.016935e-01	0.396
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	4.016935e-01	0.396
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	4.016935e-01	0.396
Deadenylation-dependent mRNA decay	R-HSA-429914	1.287835e-01	0.890
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	4.248825e-01	0.372
Cellular response to hypoxia	R-HSA-1234174	1.650963e-01	0.782
Degradation of AXIN	R-HSA-4641257	2.526947e-01	0.597
Vpr-mediated nuclear import of PICs	R-HSA-180910	2.526947e-01	0.597
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	2.065780e-01	0.685
Signaling by activated point mutants of FGFR1	R-HSA-1839122	4.471742e-01	0.350
ERKs are inactivated	R-HSA-202670	4.471742e-01	0.350
EPHA-mediated growth cone collapse	R-HSA-3928663	3.744768e-01	0.427
Viral Messenger RNA Synthesis	R-HSA-168325	2.913416e-01	0.536
RNA Polymerase II Transcription Termination	R-HSA-73856	2.913416e-01	0.536
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	3.485937e-01	0.458
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	4.293337e-01	0.367
G2/M DNA damage checkpoint	R-HSA-69473	4.062086e-01	0.391
Regulation of PD-L1(CD274) expression	R-HSA-9909648	3.436632e-01	0.464
Estrogen-dependent gene expression	R-HSA-9018519	4.006111e-01	0.397
STING mediated induction of host immune responses	R-HSA-1834941	2.450684e-01	0.611
HDMs demethylate histones	R-HSA-3214842	1.256750e-01	0.901
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	2.997976e-01	0.523
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	2.638262e-01	0.579
Listeria monocytogenes entry into host cells	R-HSA-8876384	2.886659e-01	0.540
Mitotic G1 phase and G1/S transition	R-HSA-453279	3.235331e-01	0.490
UCH proteinases	R-HSA-5689603	2.403037e-01	0.619
MyD88 dependent cascade initiated on endosome	R-HSA-975155	3.451763e-01	0.462
ERK/MAPK targets	R-HSA-198753	8.516477e-02	1.070
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	3.524775e-01	0.453
Signal attenuation	R-HSA-74749	4.016935e-01	0.396
MyD88 cascade initiated on plasma membrane	R-HSA-975871	2.637810e-01	0.579
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	2.637810e-01	0.579
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	2.637810e-01	0.579
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	2.997976e-01	0.523
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	3.382633e-01	0.471
Interleukin-1 family signaling	R-HSA-446652	2.336373e-01	0.631
Mitotic Prophase	R-HSA-68875	2.812479e-01	0.551
Translation	R-HSA-72766	2.489360e-01	0.604
Activated NTRK3 signals through PI3K	R-HSA-9603381	3.263740e-01	0.486
Formation of intermediate mesoderm	R-HSA-9761174	4.016935e-01	0.396
MET activates RAP1 and RAC1	R-HSA-8875555	4.016935e-01	0.396
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	2.113078e-01	0.675
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	2.318311e-01	0.635
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	3.319608e-01	0.479
Transcriptional regulation by small RNAs	R-HSA-5578749	3.885776e-01	0.411
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	4.225481e-01	0.374
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	3.729367e-01	0.428
HATs acetylate histones	R-HSA-3214847	4.383824e-01	0.358
Regulation of T cell activation by CD28 family	R-HSA-388841	2.994643e-01	0.524
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	3.938070e-01	0.405
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	4.285112e-01	0.368
Nuclear Envelope Breakdown	R-HSA-2980766	1.175794e-01	0.930
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	8.586804e-02	1.066
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	4.285112e-01	0.368
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	9.177323e-02	1.037
G2/M Checkpoints	R-HSA-69481	3.307959e-01	0.480
Circadian clock	R-HSA-9909396	3.687610e-01	0.433
Cardiogenesis	R-HSA-9733709	2.012019e-01	0.696
Maternal to zygotic transition (MZT)	R-HSA-9816359	9.733525e-02	1.012
TCF dependent signaling in response to WNT	R-HSA-201681	2.798650e-01	0.553
CD209 (DC-SIGN) signaling	R-HSA-5621575	3.319608e-01	0.479
S Phase	R-HSA-69242	3.351516e-01	0.475
Negative regulation of FGFR3 signaling	R-HSA-5654732	3.884096e-01	0.411
Negative regulation of FGFR4 signaling	R-HSA-5654733	4.022033e-01	0.396
Signaling by WNT	R-HSA-195721	2.793704e-01	0.554
Oxidative Stress Induced Senescence	R-HSA-2559580	2.904426e-01	0.537
Cellular response to heat stress	R-HSA-3371556	1.694294e-01	0.771
Cilium Assembly	R-HSA-5617833	2.089604e-01	0.680
Breakdown of the nuclear lamina	R-HSA-352238	1.117467e-01	0.952
CASP5-mediated substrate cleavage	R-HSA-9960525	1.792276e-01	0.747
NADE modulates death signalling	R-HSA-205025	2.110234e-01	0.676
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	2.415894e-01	0.617
Biosynthesis of DPAn-3-derived 13-series resolvins	R-HSA-9026403	2.415894e-01	0.617
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	1.193548e-01	0.923
Negative feedback regulation of MAPK pathway	R-HSA-5674499	2.709730e-01	0.567
Signalling to p38 via RIT and RIN	R-HSA-187706	2.709730e-01	0.567
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	2.992199e-01	0.524
Protein methylation	R-HSA-8876725	1.734548e-01	0.761
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	2.161293e-01	0.665
NS1 Mediated Effects on Host Pathways	R-HSA-168276	1.111482e-01	0.954
Depolymerization of the Nuclear Lamina	R-HSA-4419969	2.305694e-01	0.637
ARMS-mediated activation	R-HSA-170984	3.775710e-01	0.423
Regulation of signaling by NODAL	R-HSA-1433617	3.775710e-01	0.423
Calcineurin activates NFAT	R-HSA-2025928	3.775710e-01	0.423
Arachidonate production from DAG	R-HSA-426048	4.016935e-01	0.396
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	4.471742e-01	0.350
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	4.158477e-01	0.381
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	4.426531e-01	0.354
Death Receptor Signaling	R-HSA-73887	1.480438e-01	0.830
p53-Dependent G1 DNA Damage Response	R-HSA-69563	7.780622e-02	1.109
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	7.780622e-02	1.109
Transcriptional regulation by RUNX1	R-HSA-8878171	1.140334e-01	0.943
Beta-catenin independent WNT signaling	R-HSA-3858494	1.562380e-01	0.806
Transcriptional Regulation by VENTX	R-HSA-8853884	2.951025e-01	0.530
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	3.805370e-01	0.420
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	1.799188e-01	0.745
Adaptive Immune System	R-HSA-1280218	4.057859e-01	0.392
Transcriptional Regulation by E2F6	R-HSA-8953750	1.111482e-01	0.954
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	2.709730e-01	0.567
SWI/SNF chromatin remodelers	R-HSA-9932451	3.462395e-01	0.461
ATP-dependent chromatin remodelers	R-HSA-9932444	3.462395e-01	0.461
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	2.652846e-01	0.576
Degradation of CDH1	R-HSA-9766229	3.911149e-01	0.408
Signaling by TGFB family members	R-HSA-9006936	9.949402e-02	1.002
Signaling by BMP	R-HSA-201451	3.744768e-01	0.427
Signaling by TGF-beta Receptor Complex	R-HSA-170834	2.572161e-01	0.590
Nuclear import of Rev protein	R-HSA-180746	2.215214e-01	0.655
PI3K/AKT Signaling in Cancer	R-HSA-2219528	8.207657e-02	1.086
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	2.738124e-01	0.563
tRNA processing in the nucleus	R-HSA-6784531	3.001057e-01	0.523
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	8.500753e-02	1.071
Signaling by NTRKs	R-HSA-166520	1.263872e-01	0.898
Cellular responses to mechanical stimuli	R-HSA-9855142	2.337963e-01	0.631
VEGFA-VEGFR2 Pathway	R-HSA-4420097	1.426437e-01	0.846
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	3.521025e-01	0.453
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	2.305694e-01	0.637
Platelet degranulation	R-HSA-114608	2.033048e-01	0.692
MyD88-independent TLR4 cascade	R-HSA-166166	3.521025e-01	0.453
TCR signaling	R-HSA-202403	3.521025e-01	0.453
OAS antiviral response	R-HSA-8983711	1.324624e-01	0.878
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	3.176271e-01	0.498
Oncogene Induced Senescence	R-HSA-2559585	2.318311e-01	0.635
Programmed Cell Death	R-HSA-5357801	1.145926e-01	0.941
Signaling by VEGF	R-HSA-194138	1.933580e-01	0.714
Response of endothelial cells to shear stress	R-HSA-9860931	1.736891e-01	0.760
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	1.461524e-01	0.835
CASP4-mediated substrate cleavage	R-HSA-9960519	1.792276e-01	0.747
SMAC (DIABLO) binds to IAPs	R-HSA-111463	2.415894e-01	0.617
Activation of RAC1	R-HSA-428540	1.193548e-01	0.923
CLEC7A/inflammasome pathway	R-HSA-5660668	2.709730e-01	0.567
CREB phosphorylation	R-HSA-199920	2.992199e-01	0.524
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	3.263740e-01	0.486
Regulation of TP53 Activity through Methylation	R-HSA-6804760	2.305694e-01	0.637
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	1.620921e-01	0.790
MASTL Facilitates Mitotic Progression	R-HSA-2465910	3.775710e-01	0.423
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	3.775710e-01	0.423
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	2.741399e-01	0.562
MAP kinase activation	R-HSA-450294	1.404531e-01	0.852
Bicarbonate transporters	R-HSA-425381	4.248825e-01	0.372
FLT3 signaling in disease	R-HSA-9682385	2.422259e-01	0.616
Interactions of Rev with host cellular proteins	R-HSA-177243	2.844408e-01	0.546
Interactions of Vpr with host cellular proteins	R-HSA-176033	2.844408e-01	0.546
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	2.951025e-01	0.530
G1/S Transition	R-HSA-69206	3.182646e-01	0.497
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	3.797344e-01	0.421
Organelle biogenesis and maintenance	R-HSA-1852241	2.738980e-01	0.562
Interleukin-17 signaling	R-HSA-448424	1.980833e-01	0.703
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	4.158477e-01	0.381
Other semaphorin interactions	R-HSA-416700	1.734548e-01	0.761
Regulation of RUNX3 expression and activity	R-HSA-8941858	2.844408e-01	0.546
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	4.426531e-01	0.354
Host Interactions of HIV factors	R-HSA-162909	3.058195e-01	0.515
Glycolysis	R-HSA-70171	1.536955e-01	0.813
Signaling by MET	R-HSA-6806834	2.696898e-01	0.569
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	2.396252e-01	0.620
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	3.005359e-01	0.522
Co-stimulation by CD28	R-HSA-389356	1.826937e-01	0.738
Viral Infection Pathways	R-HSA-9824446	1.357739e-01	0.867
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	2.415894e-01	0.617
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	2.415894e-01	0.617
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	1.193548e-01	0.923
Regulation of CDH19 Expression and Function	R-HSA-9764302	2.709730e-01	0.567
Formation of the anterior neural plate	R-HSA-9823739	1.734548e-01	0.761
Syndecan interactions	R-HSA-3000170	1.087277e-01	0.964
CHL1 interactions	R-HSA-447041	3.263740e-01	0.486
Synthesis of PG	R-HSA-1483148	2.017762e-01	0.695
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	1.111482e-01	0.954
Regulated proteolysis of p75NTR	R-HSA-193692	3.775710e-01	0.423
Interleukin-1 processing	R-HSA-448706	3.775710e-01	0.423
Lipophagy	R-HSA-9613354	3.775710e-01	0.423
Protein hydroxylation	R-HSA-9629569	2.595999e-01	0.586
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	2.012019e-01	0.696
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	2.012019e-01	0.696
Basigin interactions	R-HSA-210991	2.741399e-01	0.562
Biosynthesis of DPAn-3-derived maresins	R-HSA-9026290	4.248825e-01	0.372
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	4.248825e-01	0.372
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	2.632270e-01	0.580
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	3.592695e-01	0.445
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	3.039795e-01	0.517
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	4.324572e-01	0.364
G alpha (12/13) signalling events	R-HSA-416482	4.411391e-01	0.355
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	4.342131e-01	0.362
Assembly Of The HIV Virion	R-HSA-175474	2.886659e-01	0.540
Glycogen breakdown (glycogenolysis)	R-HSA-70221	3.462395e-01	0.461
Hedgehog 'off' state	R-HSA-5610787	1.536955e-01	0.813
Neurotransmitter clearance	R-HSA-112311	4.158477e-01	0.381
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.170857e-01	0.931
Neurodegenerative Diseases	R-HSA-8863678	1.170857e-01	0.931
Glucose metabolism	R-HSA-70326	1.513262e-01	0.820
Deubiquitination	R-HSA-5688426	4.040379e-01	0.394
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	2.709730e-01	0.567
Regulation of TP53 Degradation	R-HSA-6804757	9.267766e-02	1.033
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.434969e-01	0.843
Neurexins and neuroligins	R-HSA-6794361	4.225481e-01	0.374
IRE1alpha activates chaperones	R-HSA-381070	1.088820e-01	0.963
Signaling by Hedgehog	R-HSA-5358351	2.723598e-01	0.565
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	3.263740e-01	0.486
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	2.017762e-01	0.695
Regulation of TP53 Expression and Degradation	R-HSA-6806003	1.111482e-01	0.954
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	2.886659e-01	0.540
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	3.031571e-01	0.518
Integration of provirus	R-HSA-162592	4.471742e-01	0.350
Transcriptional Regulation by MECP2	R-HSA-8986944	2.065330e-01	0.685
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.524251e-01	0.817
Gastrulation	R-HSA-9758941	3.409858e-01	0.467
VEGFR2 mediated vascular permeability	R-HSA-5218920	2.951025e-01	0.530
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	2.173679e-01	0.663
Displacement of DNA glycosylase by APEX1	R-HSA-110357	3.263740e-01	0.486
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	2.017762e-01	0.695
Unfolded Protein Response (UPR)	R-HSA-381119	9.444959e-02	1.025
MITF-M-regulated melanocyte development	R-HSA-9730414	3.175692e-01	0.498
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	3.974037e-01	0.401
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	3.885776e-01	0.411
GP1b-IX-V activation signalling	R-HSA-430116	3.775710e-01	0.423
NOD1/2 Signaling Pathway	R-HSA-168638	2.215214e-01	0.655
CD28 dependent PI3K/Akt signaling	R-HSA-389357	3.744768e-01	0.427
Cytokine Signaling in Immune system	R-HSA-1280215	1.278367e-01	0.893
Signaling by Interleukins	R-HSA-449147	2.666256e-01	0.574
Signaling by Leptin	R-HSA-2586552	4.016935e-01	0.396
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	1.458767e-01	0.836
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	2.886659e-01	0.540
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	4.225481e-01	0.374
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	2.305694e-01	0.637
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	3.319608e-01	0.479
Cytochrome c-mediated apoptotic response	R-HSA-111461	4.471742e-01	0.350
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	1.629375e-01	0.788
Heme signaling	R-HSA-9707616	3.001057e-01	0.523
Interleukin-37 signaling	R-HSA-9008059	4.158477e-01	0.381
SARS-CoV Infections	R-HSA-9679506	1.550512e-01	0.810
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	3.177191e-01	0.498
XBP1(S) activates chaperone genes	R-HSA-381038	1.768838e-01	0.752
Selenoamino acid metabolism	R-HSA-2408522	1.111920e-01	0.954
Interleukin-12 signaling	R-HSA-9020591	1.187204e-01	0.925
ER to Golgi Anterograde Transport	R-HSA-199977	2.095127e-01	0.679
Interleukin-12 family signaling	R-HSA-447115	1.826700e-01	0.738
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	4.491962e-01	0.348
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	4.491962e-01	0.348
Clathrin-mediated endocytosis	R-HSA-8856828	4.514177e-01	0.345
HDACs deacetylate histones	R-HSA-3214815	4.534107e-01	0.344
Interleukin-1 signaling	R-HSA-9020702	4.536041e-01	0.343
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	4.557985e-01	0.341
Nuclear RNA decay	R-HSA-9930044	4.557985e-01	0.341
Assembly of the ORC complex at the origin of replication	R-HSA-68616	4.557985e-01	0.341
Negative regulation of FGFR1 signaling	R-HSA-5654726	4.557985e-01	0.341
FGFR1 mutant receptor activation	R-HSA-1839124	4.557985e-01	0.341
Regulation of MECP2 expression and activity	R-HSA-9022692	4.557985e-01	0.341
Activation of ATR in response to replication stress	R-HSA-176187	4.557985e-01	0.341
Signaling by FGFR1	R-HSA-5654736	4.635475e-01	0.334
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	4.635475e-01	0.334
NRAGE signals death through JNK	R-HSA-193648	4.635475e-01	0.334
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	4.669340e-01	0.331
RUNX3 regulates p14-ARF	R-HSA-8951936	4.686031e-01	0.329
Polymerase switching	R-HSA-69091	4.686031e-01	0.329
Maple Syrup Urine Disease	R-HSA-9865114	4.686031e-01	0.329
Leading Strand Synthesis	R-HSA-69109	4.686031e-01	0.329
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	4.686031e-01	0.329
Beta oxidation of myristoyl-CoA to lauroyl-CoA	R-HSA-77285	4.686031e-01	0.329
Beta oxidation of palmitoyl-CoA to myristoyl-CoA	R-HSA-77305	4.686031e-01	0.329
RUNX3 regulates NOTCH signaling	R-HSA-8941856	4.686031e-01	0.329
VLDLR internalisation and degradation	R-HSA-8866427	4.686031e-01	0.329
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	4.686031e-01	0.329
Biosynthesis of DPAn-3-derived protectins and resolvins	R-HSA-9026286	4.686031e-01	0.329
Signaling by LTK	R-HSA-9842663	4.686031e-01	0.329
Trafficking and processing of endosomal TLR	R-HSA-1679131	4.686031e-01	0.329
Role of second messengers in netrin-1 signaling	R-HSA-418890	4.686031e-01	0.329
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	4.687635e-01	0.329
Vpu mediated degradation of CD4	R-HSA-180534	4.687635e-01	0.329
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	4.687635e-01	0.329
Regulation of CDH1 Function	R-HSA-9764561	4.736014e-01	0.325
Synthesis of PA	R-HSA-1483166	4.736014e-01	0.325
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	4.815423e-01	0.317
RAF activation	R-HSA-5673000	4.815423e-01	0.317
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	4.815423e-01	0.317
Negative regulation of FGFR2 signaling	R-HSA-5654727	4.815423e-01	0.317
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	4.815423e-01	0.317
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	4.815423e-01	0.317
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	4.815423e-01	0.317
Membrane Trafficking	R-HSA-199991	4.817138e-01	0.317
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	4.836889e-01	0.315
Activation of HOX genes during differentiation	R-HSA-5619507	4.836889e-01	0.315
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	4.892027e-01	0.311
PDH complex synthesizes acetyl-CoA from PYR	R-HSA-9861559	4.892027e-01	0.311
OGDH complex synthesizes succinyl-CoA from 2-OG	R-HSA-9853506	4.892027e-01	0.311
FGFR2c ligand binding and activation	R-HSA-190375	4.892027e-01	0.311
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	4.892027e-01	0.311
Membrane binding and targetting of GAG proteins	R-HSA-174490	4.892027e-01	0.311
FGFR4 ligand binding and activation	R-HSA-190322	4.892027e-01	0.311
Frs2-mediated activation	R-HSA-170968	4.892027e-01	0.311
Signaling by activated point mutants of FGFR3	R-HSA-1839130	4.892027e-01	0.311
FGFR3 mutant receptor activation	R-HSA-2033514	4.892027e-01	0.311
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	4.892027e-01	0.311
Platelet Adhesion to exposed collagen	R-HSA-75892	4.892027e-01	0.311
Maturation of nucleoprotein	R-HSA-9683610	4.892027e-01	0.311
Replication of the SARS-CoV-1 genome	R-HSA-9682706	4.892027e-01	0.311
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	4.934441e-01	0.307
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	4.934441e-01	0.307
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	4.941299e-01	0.306
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	4.941299e-01	0.306
Regulation of Apoptosis	R-HSA-169911	4.941299e-01	0.306
MITF-M-dependent gene expression	R-HSA-9856651	4.951805e-01	0.305
Co-inhibition by PD-1	R-HSA-389948	4.979686e-01	0.303
Oncogenic MAPK signaling	R-HSA-6802957	5.006279e-01	0.300
MAPK6/MAPK4 signaling	R-HSA-5687128	5.006279e-01	0.300
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	5.032254e-01	0.298
Signaling by ERBB2	R-HSA-1227986	5.032254e-01	0.298
Gene Silencing by RNA	R-HSA-211000	5.058702e-01	0.296
FGFR2 mutant receptor activation	R-HSA-1839126	5.065218e-01	0.295
HSF1 activation	R-HSA-3371511	5.065218e-01	0.295
Vif-mediated degradation of APOBEC3G	R-HSA-180585	5.065218e-01	0.295
G1/S-Specific Transcription	R-HSA-69205	5.065218e-01	0.295
Transport to the Golgi and subsequent modification	R-HSA-948021	5.087651e-01	0.293
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	5.089079e-01	0.293
CRMPs in Sema3A signaling	R-HSA-399956	5.090049e-01	0.293
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV	R-HSA-9859138	5.090049e-01	0.293
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	5.090049e-01	0.293
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	5.090049e-01	0.293
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	5.090049e-01	0.293
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	5.090049e-01	0.293
FGFR3c ligand binding and activation	R-HSA-190372	5.090049e-01	0.293
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	5.090049e-01	0.293
Biosynthesis of E-series 18(R)-resolvins	R-HSA-9023661	5.090049e-01	0.293
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	5.090049e-01	0.293
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	R-HSA-77350	5.090049e-01	0.293
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	R-HSA-77310	5.090049e-01	0.293
Beta oxidation of octanoyl-CoA to hexanoyl-CoA	R-HSA-77348	5.090049e-01	0.293
Physiological factors	R-HSA-5578768	5.090049e-01	0.293
Non-canonical inflammasome activation	R-HSA-9686114	5.090049e-01	0.293
Signal regulatory protein family interactions	R-HSA-391160	5.090049e-01	0.293
Acyl chain remodeling of CL	R-HSA-1482798	5.090049e-01	0.293
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	5.090049e-01	0.293
Hemostasis	R-HSA-109582	5.104269e-01	0.292
Formation of paraxial mesoderm	R-HSA-9793380	5.129088e-01	0.290
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	5.131805e-01	0.290
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	5.187144e-01	0.285
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	5.187144e-01	0.285
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	5.187144e-01	0.285
Ovarian tumor domain proteases	R-HSA-5689896	5.187144e-01	0.285
Adipogenesis	R-HSA-9843745	5.232693e-01	0.281
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	5.280406e-01	0.277
RNA Polymerase III Chain Elongation	R-HSA-73780	5.280406e-01	0.277
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	5.280406e-01	0.277
DCC mediated attractive signaling	R-HSA-418885	5.280406e-01	0.277
Translesion synthesis by REV1	R-HSA-110312	5.280406e-01	0.277
ERBB2 Regulates Cell Motility	R-HSA-6785631	5.280406e-01	0.277
FGFR3 ligand binding and activation	R-HSA-190239	5.280406e-01	0.277
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	5.280406e-01	0.277
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	5.280406e-01	0.277
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	5.280406e-01	0.277
Spry regulation of FGF signaling	R-HSA-1295596	5.280406e-01	0.277
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	5.280406e-01	0.277
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	5.319695e-01	0.274
Diseases of programmed cell death	R-HSA-9645723	5.333646e-01	0.273
ER-Phagosome pathway	R-HSA-1236974	5.413819e-01	0.266
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	5.424894e-01	0.266
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	5.424894e-01	0.266
Stabilization of p53	R-HSA-69541	5.424894e-01	0.266
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	5.463394e-01	0.263
Translesion synthesis by POLI	R-HSA-5656121	5.463394e-01	0.263
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	5.463394e-01	0.263
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	5.463394e-01	0.263
Regulation of NF-kappa B signaling	R-HSA-9758274	5.463394e-01	0.263
Class I peroxisomal membrane protein import	R-HSA-9603798	5.463394e-01	0.263
Prolonged ERK activation events	R-HSA-169893	5.463394e-01	0.263
WNT5A-dependent internalization of FZD4	R-HSA-5099900	5.463394e-01	0.263
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	5.463394e-01	0.263
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	5.463394e-01	0.263
Carnitine synthesis	R-HSA-71262	5.463394e-01	0.263
Downstream TCR signaling	R-HSA-202424	5.493283e-01	0.260
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	5.506039e-01	0.259
Inhibition of DNA recombination at telomere	R-HSA-9670095	5.540670e-01	0.256
Attenuation phase	R-HSA-3371568	5.540670e-01	0.256
Generation of second messenger molecules	R-HSA-202433	5.540670e-01	0.256
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	5.540670e-01	0.256
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	5.540670e-01	0.256
Diseases of Immune System	R-HSA-5260271	5.540670e-01	0.256
Diseases associated with the TLR signaling cascade	R-HSA-5602358	5.540670e-01	0.256
Negative regulation of NOTCH4 signaling	R-HSA-9604323	5.540670e-01	0.256
Glycogen metabolism	R-HSA-8982491	5.540670e-01	0.256
Pre-NOTCH Transcription and Translation	R-HSA-1912408	5.572020e-01	0.254
Translesion synthesis by POLK	R-HSA-5655862	5.639298e-01	0.249
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	5.639298e-01	0.249
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	5.639298e-01	0.249
Transcriptional regulation of testis differentiation	R-HSA-9690406	5.639298e-01	0.249
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	R-HSA-77288	5.639298e-01	0.249
Vitamin B6 activation to pyridoxal phosphate	R-HSA-964975	5.639298e-01	0.249
Glycine degradation	R-HSA-6783984	5.639298e-01	0.249
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	5.639298e-01	0.249
TRAF3-dependent IRF activation pathway	R-HSA-918233	5.639298e-01	0.249
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	R-HSA-77346	5.639298e-01	0.249
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	5.639298e-01	0.249
Response to metal ions	R-HSA-5660526	5.639298e-01	0.249
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	5.639298e-01	0.249
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	5.654358e-01	0.248
Maturation of spike protein	R-HSA-9694548	5.654358e-01	0.248
Hh mutants are degraded by ERAD	R-HSA-5362768	5.654358e-01	0.248
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	5.654358e-01	0.248
Resolution of Abasic Sites (AP sites)	R-HSA-73933	5.654358e-01	0.248
Muscle contraction	R-HSA-397014	5.667145e-01	0.247
DNA Double Strand Break Response	R-HSA-5693606	5.687932e-01	0.245
TP53 Regulates Metabolic Genes	R-HSA-5628897	5.699138e-01	0.244
Signaling by FGFR1 in disease	R-HSA-5655302	5.765945e-01	0.239
Degradation of CRY and PER proteins	R-HSA-9932298	5.765945e-01	0.239
Degradation of GLI1 by the proteasome	R-HSA-5610780	5.765945e-01	0.239
Negative regulation of MAPK pathway	R-HSA-5675221	5.765945e-01	0.239
Degradation of GLI2 by the proteasome	R-HSA-5610783	5.765945e-01	0.239
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	5.765945e-01	0.239
Transcription of the HIV genome	R-HSA-167172	5.777161e-01	0.238
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	5.803706e-01	0.236
Assembly of the pre-replicative complex	R-HSA-68867	5.803706e-01	0.236
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	5.808391e-01	0.236
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	5.808391e-01	0.236
Biosynthesis of aspirin-triggered D-series resolvins	R-HSA-9020265	5.808391e-01	0.236
Elevation of cytosolic Ca2+ levels	R-HSA-139853	5.808391e-01	0.236
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	5.808391e-01	0.236
Regulation of NPAS4 gene expression	R-HSA-9768759	5.808391e-01	0.236
Replication of the SARS-CoV-2 genome	R-HSA-9694686	5.808391e-01	0.236
Cleavage of the damaged pyrimidine	R-HSA-110329	5.875422e-01	0.231
Depyrimidination	R-HSA-73928	5.875422e-01	0.231
Collagen formation	R-HSA-1474290	5.879376e-01	0.231
Mitochondrial biogenesis	R-HSA-1592230	5.902906e-01	0.229
Ephrin signaling	R-HSA-3928664	5.970938e-01	0.224
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	5.970938e-01	0.224
RNA Polymerase III Transcription Termination	R-HSA-73980	5.970938e-01	0.224
Activated point mutants of FGFR2	R-HSA-2033519	5.970938e-01	0.224
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	5.970938e-01	0.224
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	5.970938e-01	0.224
Biosynthesis of Lipoxins (LX)	R-HSA-2142700	5.970938e-01	0.224
Chaperone Mediated Autophagy	R-HSA-9613829	5.970938e-01	0.224
Apoptotic factor-mediated response	R-HSA-111471	5.970938e-01	0.224
Platelet sensitization by LDL	R-HSA-432142	5.970938e-01	0.224
Tie2 Signaling	R-HSA-210993	5.970938e-01	0.224
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	5.970938e-01	0.224
Transmission across Chemical Synapses	R-HSA-112315	5.973287e-01	0.224
Signaling by FGFR4	R-HSA-5654743	5.982787e-01	0.223
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	5.982787e-01	0.223
Hh mutants abrogate ligand secretion	R-HSA-5387390	5.982787e-01	0.223
Signaling by SCF-KIT	R-HSA-1433557	5.982787e-01	0.223
Transcriptional regulation by RUNX2	R-HSA-8878166	6.035763e-01	0.219
NoRC negatively regulates rRNA expression	R-HSA-427413	6.037780e-01	0.219
Hedgehog 'on' state	R-HSA-5632684	6.037780e-01	0.219
RMTs methylate histone arginines	R-HSA-3214858	6.088037e-01	0.216
Netrin-1 signaling	R-HSA-373752	6.088037e-01	0.216
Amine ligand-binding receptors	R-HSA-375280	6.088037e-01	0.216
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	6.101526e-01	0.215
Platelet activation, signaling and aggregation	R-HSA-76002	6.124521e-01	0.213
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	6.127191e-01	0.213
Impaired BRCA2 binding to PALB2	R-HSA-9709603	6.127191e-01	0.213
PI-3K cascade:FGFR3	R-HSA-5654710	6.127191e-01	0.213
Translesion Synthesis by POLH	R-HSA-110320	6.127191e-01	0.213
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	6.127191e-01	0.213
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	6.127191e-01	0.213
IKK complex recruitment mediated by RIP1	R-HSA-937041	6.127191e-01	0.213
E2F mediated regulation of DNA replication	R-HSA-113510	6.127191e-01	0.213
Synthesis of 5-eicosatetraenoic acids	R-HSA-2142688	6.127191e-01	0.213
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	6.127191e-01	0.213
Rap1 signalling	R-HSA-392517	6.127191e-01	0.213
Maturation of nucleoprotein	R-HSA-9694631	6.127191e-01	0.213
Other interleukin signaling	R-HSA-449836	6.127191e-01	0.213
The NLRP3 inflammasome	R-HSA-844456	6.127191e-01	0.213
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	6.127191e-01	0.213
Chromosome Maintenance	R-HSA-73886	6.166137e-01	0.210
Telomere Maintenance	R-HSA-157579	6.173919e-01	0.209
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	6.191176e-01	0.208
Nucleosome assembly	R-HSA-774815	6.191176e-01	0.208
Signaling by FGFR3	R-HSA-5654741	6.191176e-01	0.208
Defective CFTR causes cystic fibrosis	R-HSA-5678895	6.191176e-01	0.208
Somitogenesis	R-HSA-9824272	6.191176e-01	0.208
Regulation of PD-L1(CD274) translation	R-HSA-9909620	6.277393e-01	0.202
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	6.277393e-01	0.202
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	6.277393e-01	0.202
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	6.277393e-01	0.202
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	6.277393e-01	0.202
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	6.277393e-01	0.202
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	6.277393e-01	0.202
PI-3K cascade:FGFR4	R-HSA-5654720	6.277393e-01	0.202
Co-inhibition by CTLA4	R-HSA-389513	6.277393e-01	0.202
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	6.277393e-01	0.202
Negative regulation of MET activity	R-HSA-6807004	6.277393e-01	0.202
Signaling by NODAL	R-HSA-1181150	6.277393e-01	0.202
Signal transduction by L1	R-HSA-445144	6.277393e-01	0.202
RNA Polymerase II Pre-transcription Events	R-HSA-674695	6.287546e-01	0.202
Signaling by FGFR in disease	R-HSA-1226099	6.287546e-01	0.202
Signaling by NOTCH4	R-HSA-9013694	6.287546e-01	0.202
mRNA Splicing - Minor Pathway	R-HSA-72165	6.292208e-01	0.201
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	6.292208e-01	0.201
Regulation of TNFR1 signaling	R-HSA-5357905	6.292208e-01	0.201
Regulation of pyruvate metabolism	R-HSA-9861718	6.292208e-01	0.201
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	6.293959e-01	0.201
Ub-specific processing proteases	R-HSA-5689880	6.343998e-01	0.198
Non-integrin membrane-ECM interactions	R-HSA-3000171	6.368349e-01	0.196
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	6.391143e-01	0.194
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	6.391143e-01	0.194
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	6.397144e-01	0.194
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	6.402467e-01	0.194
SHC-mediated cascade:FGFR3	R-HSA-5654704	6.421779e-01	0.192
FGFR2 ligand binding and activation	R-HSA-190241	6.421779e-01	0.192
Early Phase of HIV Life Cycle	R-HSA-162594	6.421779e-01	0.192
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	6.421779e-01	0.192
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	6.421779e-01	0.192
TNFR1-induced proapoptotic signaling	R-HSA-5357786	6.421779e-01	0.192
Lagging Strand Synthesis	R-HSA-69186	6.421779e-01	0.192
Biosynthesis of E-series 18(S)-resolvins	R-HSA-9018896	6.421779e-01	0.192
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	6.421779e-01	0.192
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	6.421779e-01	0.192
Zygotic genome activation (ZGA)	R-HSA-9819196	6.421779e-01	0.192
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	6.421779e-01	0.192
NGF-stimulated transcription	R-HSA-9031628	6.487990e-01	0.188
Gluconeogenesis	R-HSA-70263	6.487990e-01	0.188
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	6.487990e-01	0.188
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	6.523063e-01	0.186
Translation of Structural Proteins	R-HSA-9694635	6.526243e-01	0.185
FRS-mediated FGFR3 signaling	R-HSA-5654706	6.560573e-01	0.183
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	6.560573e-01	0.183
SHC-mediated cascade:FGFR4	R-HSA-5654719	6.560573e-01	0.183
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	6.560573e-01	0.183
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	6.560573e-01	0.183
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	6.560573e-01	0.183
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	6.560573e-01	0.183
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	6.560573e-01	0.183
Serine metabolism	R-HSA-977347	6.560573e-01	0.183
Signaling by NTRK3 (TRKC)	R-HSA-9034015	6.560573e-01	0.183
Signaling by PDGFR in disease	R-HSA-9671555	6.560573e-01	0.183
Integrin cell surface interactions	R-HSA-216083	6.603327e-01	0.180
Signaling by FGFR2 in disease	R-HSA-5655253	6.675477e-01	0.176
PI3K Cascade	R-HSA-109704	6.675477e-01	0.176
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	6.679168e-01	0.175
DNA Replication	R-HSA-69306	6.680259e-01	0.175
FRS-mediated FGFR4 signaling	R-HSA-5654712	6.693991e-01	0.174
PI-3K cascade:FGFR1	R-HSA-5654689	6.693991e-01	0.174
Notch-HLH transcription pathway	R-HSA-350054	6.693991e-01	0.174
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	6.693991e-01	0.174
Biosynthesis of D-series resolvins	R-HSA-9018676	6.693991e-01	0.174
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	6.693991e-01	0.174
LDL clearance	R-HSA-8964038	6.693991e-01	0.174
Ethanol oxidation	R-HSA-71384	6.693991e-01	0.174
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	6.693991e-01	0.174
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	6.753766e-01	0.170
RAF/MAP kinase cascade	R-HSA-5673001	6.759704e-01	0.170
Meiotic recombination	R-HSA-912446	6.766149e-01	0.170
Hedgehog ligand biogenesis	R-HSA-5358346	6.766149e-01	0.170
Negative regulation of the PI3K/AKT network	R-HSA-199418	6.778661e-01	0.169
Regulation of PTEN mRNA translation	R-HSA-8943723	6.822242e-01	0.166
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	6.822242e-01	0.166
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	6.822242e-01	0.166
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	6.822242e-01	0.166
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	6.822242e-01	0.166
Formation of the ureteric bud	R-HSA-9830674	6.822242e-01	0.166
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	6.822242e-01	0.166
Carnitine shuttle	R-HSA-200425	6.822242e-01	0.166
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	6.822242e-01	0.166
Biosynthesis of maresins	R-HSA-9018682	6.822242e-01	0.166
Growth hormone receptor signaling	R-HSA-982772	6.822242e-01	0.166
Processing of DNA double-strand break ends	R-HSA-5693607	6.827121e-01	0.166
Reproduction	R-HSA-1474165	6.836176e-01	0.165
RNA Polymerase I Promoter Escape	R-HSA-73772	6.854798e-01	0.164
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	6.854798e-01	0.164
Orc1 removal from chromatin	R-HSA-68949	6.854798e-01	0.164
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	6.854798e-01	0.164
Transcriptional Regulation by NPAS4	R-HSA-9634815	6.854798e-01	0.164
ESR-mediated signaling	R-HSA-8939211	6.857489e-01	0.164
MAPK family signaling cascades	R-HSA-5683057	6.910797e-01	0.160
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	6.941444e-01	0.159
Amino acids regulate mTORC1	R-HSA-9639288	6.941444e-01	0.159
Smooth Muscle Contraction	R-HSA-445355	6.941444e-01	0.159
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	6.941444e-01	0.159
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	6.941444e-01	0.159
Regulation of PTEN stability and activity	R-HSA-8948751	6.941444e-01	0.159
SHC-mediated cascade:FGFR1	R-HSA-5654688	6.945525e-01	0.158
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	6.945525e-01	0.158
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	6.945525e-01	0.158
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	6.945525e-01	0.158
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	6.970112e-01	0.157
Antigen processing-Cross presentation	R-HSA-1236975	6.974963e-01	0.156
Cellular response to chemical stress	R-HSA-9711123	7.009045e-01	0.154
Epigenetic regulation of gene expression	R-HSA-212165	7.024504e-01	0.153
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	7.026109e-01	0.153
Base-Excision Repair, AP Site Formation	R-HSA-73929	7.026109e-01	0.153
MAPK1/MAPK3 signaling	R-HSA-5684996	7.034343e-01	0.153
DNA Replication Pre-Initiation	R-HSA-69002	7.035955e-01	0.153
FRS-mediated FGFR1 signaling	R-HSA-5654693	7.064033e-01	0.151
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	7.064033e-01	0.151
PI-3K cascade:FGFR2	R-HSA-5654695	7.064033e-01	0.151
Polymerase switching on the C-strand of the telomere	R-HSA-174411	7.064033e-01	0.151
Long-term potentiation	R-HSA-9620244	7.064033e-01	0.151
Laminin interactions	R-HSA-3000157	7.064033e-01	0.151
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives	R-HSA-9027604	7.064033e-01	0.151
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	7.064033e-01	0.151
Formation of the nephric duct	R-HSA-9830364	7.064033e-01	0.151
Interleukin-7 signaling	R-HSA-1266695	7.064033e-01	0.151
Protein-protein interactions at synapses	R-HSA-6794362	7.108171e-01	0.148
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	7.108817e-01	0.148
Signaling by NOTCH3	R-HSA-9012852	7.108817e-01	0.148
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	7.177949e-01	0.144
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	7.177949e-01	0.144
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	7.177949e-01	0.144
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	7.177949e-01	0.144
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	7.177949e-01	0.144
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	7.177949e-01	0.144
Myogenesis	R-HSA-525793	7.177949e-01	0.144
TRP channels	R-HSA-3295583	7.177949e-01	0.144
TNF signaling	R-HSA-75893	7.189591e-01	0.143
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	7.189591e-01	0.143
Ion homeostasis	R-HSA-5578775	7.189591e-01	0.143
Inositol phosphate metabolism	R-HSA-1483249	7.213576e-01	0.142
Toll-like Receptor Cascades	R-HSA-168898	7.229158e-01	0.141
IRS-mediated signalling	R-HSA-112399	7.268458e-01	0.139
Pre-NOTCH Expression and Processing	R-HSA-1912422	7.271003e-01	0.138
SHC-mediated cascade:FGFR2	R-HSA-5654699	7.287453e-01	0.137
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	7.287453e-01	0.137
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	7.287453e-01	0.137
Packaging Of Telomere Ends	R-HSA-171306	7.287453e-01	0.137
RNA Polymerase I Transcription Termination	R-HSA-73863	7.287453e-01	0.137
Signaling by FGFR3 in disease	R-HSA-5655332	7.287453e-01	0.137
RNA Polymerase I Promoter Opening	R-HSA-73728	7.287453e-01	0.137
Biosynthesis of DPAn-3 SPMs	R-HSA-9025094	7.287453e-01	0.137
Triglyceride biosynthesis	R-HSA-75109	7.287453e-01	0.137
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	7.287453e-01	0.137
Maturation of hRSV A proteins	R-HSA-9828806	7.287453e-01	0.137
Pyruvate metabolism	R-HSA-70268	7.306109e-01	0.136
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	7.327544e-01	0.135
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	7.345443e-01	0.134
Early SARS-CoV-2 Infection Events	R-HSA-9772572	7.345443e-01	0.134
Neuronal System	R-HSA-112316	7.353220e-01	0.134
FRS-mediated FGFR2 signaling	R-HSA-5654700	7.392713e-01	0.131
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	7.392713e-01	0.131
Formation of the Early Elongation Complex	R-HSA-113418	7.392713e-01	0.131
HIV elongation arrest and recovery	R-HSA-167287	7.392713e-01	0.131
Pausing and recovery of HIV elongation	R-HSA-167290	7.392713e-01	0.131
Pyroptosis	R-HSA-5620971	7.392713e-01	0.131
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	7.392713e-01	0.131
Telomere Extension By Telomerase	R-HSA-171319	7.392713e-01	0.131
Pyrimidine salvage	R-HSA-73614	7.392713e-01	0.131
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	7.392713e-01	0.131
Inflammasomes	R-HSA-622312	7.392713e-01	0.131
Extension of Telomeres	R-HSA-180786	7.420574e-01	0.130
Signaling by Nuclear Receptors	R-HSA-9006931	7.458087e-01	0.127
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	7.471855e-01	0.127
Interferon alpha/beta signaling	R-HSA-909733	7.491881e-01	0.125
Base Excision Repair	R-HSA-73884	7.493244e-01	0.125
Metabolism of polyamines	R-HSA-351202	7.493878e-01	0.125
DNA methylation	R-HSA-5334118	7.493896e-01	0.125
Impaired BRCA2 binding to RAD51	R-HSA-9709570	7.493896e-01	0.125
Downstream signaling of activated FGFR3	R-HSA-5654708	7.493896e-01	0.125
mRNA Capping	R-HSA-72086	7.493896e-01	0.125
Termination of translesion DNA synthesis	R-HSA-5656169	7.493896e-01	0.125
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	7.493896e-01	0.125
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	7.493896e-01	0.125
Late endosomal microautophagy	R-HSA-9615710	7.493896e-01	0.125
Platelet calcium homeostasis	R-HSA-418360	7.493896e-01	0.125
Biosynthesis of EPA-derived SPMs	R-HSA-9018679	7.493896e-01	0.125
DARPP-32 events	R-HSA-180024	7.493896e-01	0.125
IRS-related events triggered by IGF1R	R-HSA-2428928	7.565385e-01	0.121
Regulation of RUNX2 expression and activity	R-HSA-8939902	7.565385e-01	0.121
Downstream signaling of activated FGFR4	R-HSA-5654716	7.591157e-01	0.120
DAP12 signaling	R-HSA-2424491	7.591157e-01	0.120
GABA synthesis, release, reuptake and degradation	R-HSA-888590	7.591157e-01	0.120
Downregulation of ERBB2 signaling	R-HSA-8863795	7.591157e-01	0.120
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	7.591157e-01	0.120
C-type lectin receptors (CLRs)	R-HSA-5621481	7.606443e-01	0.119
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	7.635123e-01	0.117
Transcriptional regulation of granulopoiesis	R-HSA-9616222	7.635123e-01	0.117
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	7.635123e-01	0.117
Signaling by PDGF	R-HSA-186797	7.635123e-01	0.117
Homology Directed Repair	R-HSA-5693538	7.648372e-01	0.116
Late SARS-CoV-2 Infection Events	R-HSA-9772573	7.669829e-01	0.115
EGFR downregulation	R-HSA-182971	7.684650e-01	0.114
Biosynthesis of DPA-derived SPMs	R-HSA-9018683	7.684650e-01	0.114
Molecules associated with elastic fibres	R-HSA-2129379	7.684650e-01	0.114
Evasion by RSV of host interferon responses	R-HSA-9833109	7.684650e-01	0.114
Downstream signal transduction	R-HSA-186763	7.684650e-01	0.114
rRNA modification in the nucleus and cytosol	R-HSA-6790901	7.703121e-01	0.113
Signaling by PTK6	R-HSA-8848021	7.703121e-01	0.113
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	7.703121e-01	0.113
Insulin receptor signalling cascade	R-HSA-74751	7.769410e-01	0.110
IGF1R signaling cascade	R-HSA-2428924	7.769410e-01	0.110
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	7.774519e-01	0.109
DNA strand elongation	R-HSA-69190	7.774519e-01	0.109
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	7.774519e-01	0.109
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	7.781835e-01	0.109
Mitochondrial protein degradation	R-HSA-9837999	7.781835e-01	0.109
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	7.834020e-01	0.106
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	7.836157e-01	0.106
Defective B3GALTL causes PpS	R-HSA-5083635	7.860905e-01	0.105
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	7.860905e-01	0.105
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	7.860905e-01	0.105
Integrin signaling	R-HSA-354192	7.860905e-01	0.105
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	7.860905e-01	0.105
G-protein beta:gamma signalling	R-HSA-397795	7.860905e-01	0.105
Immune System	R-HSA-168256	7.922726e-01	0.101
Resolution of D-Loop Structures	R-HSA-5693537	7.943943e-01	0.100
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	7.943943e-01	0.100
DNA Damage Recognition in GG-NER	R-HSA-5696394	7.943943e-01	0.100
Effects of PIP2 hydrolysis	R-HSA-114508	7.943943e-01	0.100
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	7.943943e-01	0.100
HDR through Homologous Recombination (HRR)	R-HSA-5685942	7.958324e-01	0.099
Kidney development	R-HSA-9830369	7.958324e-01	0.099
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	8.018079e-01	0.096
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	8.023763e-01	0.096
Dual Incision in GG-NER	R-HSA-5696400	8.023763e-01	0.096
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	8.023763e-01	0.096
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	8.023763e-01	0.096
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	8.023763e-01	0.096
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	8.023763e-01	0.096
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	8.023763e-01	0.096
Mitophagy	R-HSA-5205647	8.023763e-01	0.096
NPAS4 regulates expression of target genes	R-HSA-9768919	8.023763e-01	0.096
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	8.076277e-01	0.093
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	8.087908e-01	0.092
Downstream signaling of activated FGFR1	R-HSA-5654687	8.100489e-01	0.091
Downstream signaling of activated FGFR2	R-HSA-5654696	8.100489e-01	0.091
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	8.100489e-01	0.091
Signalling to ERKs	R-HSA-187687	8.100489e-01	0.091
PERK regulates gene expression	R-HSA-381042	8.100489e-01	0.091
PRC2 methylates histones and DNA	R-HSA-212300	8.174240e-01	0.088
GPVI-mediated activation cascade	R-HSA-114604	8.174240e-01	0.088
RUNX2 regulates bone development	R-HSA-8941326	8.174240e-01	0.088
Extracellular matrix organization	R-HSA-1474244	8.179879e-01	0.087
ECM proteoglycans	R-HSA-3000178	8.188126e-01	0.087
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	8.188126e-01	0.087
Regulation of mitotic cell cycle	R-HSA-453276	8.188126e-01	0.087
HCMV Late Events	R-HSA-9610379	8.203096e-01	0.086
PI Metabolism	R-HSA-1483255	8.232139e-01	0.084
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	8.245132e-01	0.084
O-glycosylation of TSR domain-containing proteins	R-HSA-5173214	8.245132e-01	0.084
Voltage gated Potassium channels	R-HSA-1296072	8.245132e-01	0.084
SIRT1 negatively regulates rRNA expression	R-HSA-427359	8.245132e-01	0.084
TRAF6 mediated IRF7 activation	R-HSA-933541	8.245132e-01	0.084
Cleavage of the damaged purine	R-HSA-110331	8.245132e-01	0.084
Lysine catabolism	R-HSA-71064	8.245132e-01	0.084
Collagen chain trimerization	R-HSA-8948216	8.245132e-01	0.084
Metabolism of folate and pterines	R-HSA-196757	8.245132e-01	0.084
Vesicle-mediated transport	R-HSA-5653656	8.259598e-01	0.083
Switching of origins to a post-replicative state	R-HSA-69052	8.294115e-01	0.081
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	8.313275e-01	0.080
Depurination	R-HSA-73927	8.313275e-01	0.080
Elastic fibre formation	R-HSA-1566948	8.313275e-01	0.080
SLC-mediated transport of inorganic anions	R-HSA-9958790	8.313275e-01	0.080
RSV-host interactions	R-HSA-9833110	8.363857e-01	0.078
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	8.378777e-01	0.077
Plasma lipoprotein clearance	R-HSA-8964043	8.378777e-01	0.077
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	8.378777e-01	0.077
Pentose phosphate pathway	R-HSA-71336	8.378777e-01	0.077
Signaling by ALK	R-HSA-201556	8.378777e-01	0.077
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	8.378777e-01	0.077
Protein ubiquitination	R-HSA-8852135	8.394488e-01	0.076
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	8.441739e-01	0.074
HIV Transcription Elongation	R-HSA-167169	8.441739e-01	0.074
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	8.441739e-01	0.074
Synthesis of DNA	R-HSA-69239	8.487033e-01	0.071
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	8.502259e-01	0.070
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	8.502259e-01	0.070
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	8.502259e-01	0.070
FLT3 Signaling	R-HSA-9607240	8.502259e-01	0.070
Infectious disease	R-HSA-5663205	8.522663e-01	0.069
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	8.535041e-01	0.069
ABC transporter disorders	R-HSA-5619084	8.535041e-01	0.069
Signaling by RAF1 mutants	R-HSA-9656223	8.560432e-01	0.068
MAP2K and MAPK activation	R-HSA-5674135	8.560432e-01	0.068
Scavenging by Class A Receptors	R-HSA-3000480	8.560432e-01	0.068
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	8.560432e-01	0.068
SLC-mediated transport of neurotransmitters	R-HSA-442660	8.560432e-01	0.068
Translation of Structural Proteins	R-HSA-9683701	8.560432e-01	0.068
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	8.572596e-01	0.067
Incretin synthesis, secretion, and inactivation	R-HSA-400508	8.616349e-01	0.065
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	8.622415e-01	0.064
tRNA processing	R-HSA-72306	8.668548e-01	0.062
Defective pyroptosis	R-HSA-9710421	8.670098e-01	0.062
TBC/RABGAPs	R-HSA-8854214	8.670098e-01	0.062
Developmental Cell Lineages	R-HSA-9734767	8.701255e-01	0.060
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	8.721761e-01	0.059
DAP12 interactions	R-HSA-2172127	8.721761e-01	0.059
Cytoprotection by HMOX1	R-HSA-9707564	8.744555e-01	0.058
mitochondrial fatty acid beta-oxidation of saturated fatty acids	R-HSA-77286	8.771421e-01	0.057
Platelet Aggregation (Plug Formation)	R-HSA-76009	8.771421e-01	0.057
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	8.783000e-01	0.056
Metabolism of amino acids and derivatives	R-HSA-71291	8.809360e-01	0.055
Cell surface interactions at the vascular wall	R-HSA-202733	8.810344e-01	0.055
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	8.819154e-01	0.055
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	8.819154e-01	0.055
Signaling downstream of RAS mutants	R-HSA-9649948	8.819154e-01	0.055
Condensation of Prophase Chromosomes	R-HSA-2299718	8.819154e-01	0.055
Signaling by RAS mutants	R-HSA-6802949	8.819154e-01	0.055
Diseases of DNA repair	R-HSA-9675135	8.819154e-01	0.055
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	8.819154e-01	0.055
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	8.819154e-01	0.055
FCERI mediated NF-kB activation	R-HSA-2871837	8.822035e-01	0.054
Signaling by NOTCH	R-HSA-157118	8.878778e-01	0.052
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	8.891910e-01	0.051
GPER1 signaling	R-HSA-9634597	8.909138e-01	0.050
DNA Damage Bypass	R-HSA-73893	8.951528e-01	0.048
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	8.951528e-01	0.048
Glyoxylate metabolism and glycine degradation	R-HSA-389661	8.951528e-01	0.048
Branched-chain amino acid catabolism	R-HSA-70895	9.031439e-01	0.044
Complex IV assembly	R-HSA-9864848	9.031439e-01	0.044
DNA Double-Strand Break Repair	R-HSA-5693532	9.056568e-01	0.043
Formation of RNA Pol II elongation complex	R-HSA-112382	9.069083e-01	0.042
RNA Polymerase II Transcription Elongation	R-HSA-75955	9.105267e-01	0.041
Nucleotide biosynthesis	R-HSA-8956320	9.105267e-01	0.041
Signaling by Insulin receptor	R-HSA-74752	9.111806e-01	0.040
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	9.205609e-01	0.036
Signaling by EGFR	R-HSA-177929	9.205609e-01	0.036
Intrinsic Pathway for Apoptosis	R-HSA-109606	9.205609e-01	0.036
Dual incision in TC-NER	R-HSA-6782135	9.266179e-01	0.033
Triglyceride metabolism	R-HSA-8979227	9.294713e-01	0.032
Regulation of beta-cell development	R-HSA-186712	9.294713e-01	0.032
Cardiac conduction	R-HSA-5576891	9.296694e-01	0.032
Phospholipid metabolism	R-HSA-1483257	9.300021e-01	0.032
Synthesis of bile acids and bile salts	R-HSA-192105	9.312851e-01	0.031
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	9.322139e-01	0.030
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	9.322139e-01	0.030
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	9.322139e-01	0.030
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	9.322139e-01	0.030
Signaling by NOTCH1 in Cancer	R-HSA-2644603	9.322139e-01	0.030
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.322139e-01	0.030
Signaling by Retinoic Acid	R-HSA-5362517	9.322139e-01	0.030
ABC-family proteins mediated transport	R-HSA-382556	9.334722e-01	0.030
SLC transporter disorders	R-HSA-5619102	9.339673e-01	0.030
Nucleotide salvage	R-HSA-8956321	9.348499e-01	0.029
Collagen degradation	R-HSA-1442490	9.348499e-01	0.029
Extra-nuclear estrogen signaling	R-HSA-9009391	9.355932e-01	0.029
Mitochondrial protein import	R-HSA-1268020	9.373836e-01	0.028
NCAM signaling for neurite out-growth	R-HSA-375165	9.373836e-01	0.028
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.379488e-01	0.028
Glycerophospholipid biosynthesis	R-HSA-1483206	9.379488e-01	0.028
Integration of energy metabolism	R-HSA-163685	9.407487e-01	0.027
CD22 mediated BCR regulation	R-HSA-5690714	9.421597e-01	0.026
Innate Immune System	R-HSA-168249	9.428807e-01	0.026
Nucleotide Excision Repair	R-HSA-5696398	9.452711e-01	0.024
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.465721e-01	0.024
Platelet homeostasis	R-HSA-418346	9.470330e-01	0.024
Leishmania phagocytosis	R-HSA-9664417	9.472130e-01	0.024
Parasite infection	R-HSA-9664407	9.472130e-01	0.024
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.472130e-01	0.024
Nicotinate metabolism	R-HSA-196807	9.486505e-01	0.023
Stimuli-sensing channels	R-HSA-2672351	9.503961e-01	0.022
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	9.506483e-01	0.022
Regulated Necrosis	R-HSA-5218859	9.506483e-01	0.022
Disorders of transmembrane transporters	R-HSA-5619115	9.522463e-01	0.021
Bile acid and bile salt metabolism	R-HSA-194068	9.535549e-01	0.021
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.561878e-01	0.019
Ca2+ pathway	R-HSA-4086398	9.595314e-01	0.018
Potential therapeutics for SARS	R-HSA-9679191	9.617631e-01	0.017
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	9.626202e-01	0.017
Citric acid cycle (TCA cycle)	R-HSA-71403	9.626202e-01	0.017
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.626202e-01	0.017
Role of phospholipids in phagocytosis	R-HSA-2029485	9.631640e-01	0.016
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.639662e-01	0.016
Signaling by NOTCH1	R-HSA-1980143	9.640751e-01	0.016
Rab regulation of trafficking	R-HSA-9007101	9.655386e-01	0.015
Peptide hormone metabolism	R-HSA-2980736	9.655386e-01	0.015
PPARA activates gene expression	R-HSA-1989781	9.670480e-01	0.015
Sensory processing of sound	R-HSA-9659379	9.681095e-01	0.014
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.683946e-01	0.014
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.689626e-01	0.014
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.705444e-01	0.013
Amyloid fiber formation	R-HSA-977225	9.705444e-01	0.013
Formation of the cornified envelope	R-HSA-6809371	9.727440e-01	0.012
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	9.745201e-01	0.011
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	9.745201e-01	0.011
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	9.745201e-01	0.011
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	9.758502e-01	0.011
Parasitic Infection Pathways	R-HSA-9824443	9.790577e-01	0.009
Leishmania infection	R-HSA-9658195	9.790577e-01	0.009
Neurotransmitter release cycle	R-HSA-112310	9.802015e-01	0.009
Degradation of the extracellular matrix	R-HSA-1474228	9.805700e-01	0.009
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.810318e-01	0.008
Asparagine N-linked glycosylation	R-HSA-446203	9.810949e-01	0.008
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.824268e-01	0.008
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.844023e-01	0.007
Potassium Channels	R-HSA-1296071	9.855945e-01	0.006
Post-translational protein phosphorylation	R-HSA-8957275	9.866958e-01	0.006
Post-translational protein modification	R-HSA-597592	9.880953e-01	0.005
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.890949e-01	0.005
Opioid Signalling	R-HSA-111885	9.895202e-01	0.005
Protein localization	R-HSA-9609507	9.911947e-01	0.004
FCERI mediated MAPK activation	R-HSA-2871796	9.926747e-01	0.003
Interferon gamma signaling	R-HSA-877300	9.928561e-01	0.003
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.934993e-01	0.003
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.939968e-01	0.003
Regulation of Complement cascade	R-HSA-977606	9.959690e-01	0.002
Neddylation	R-HSA-8951664	9.960833e-01	0.002
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.962070e-01	0.002
Disease	R-HSA-1643685	9.964562e-01	0.002
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.970809e-01	0.001
DNA Repair	R-HSA-73894	9.974458e-01	0.001
Ion channel transport	R-HSA-983712	9.976093e-01	0.001
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	9.977303e-01	0.001
Metabolism of steroids	R-HSA-8957322	9.977338e-01	0.001
O-linked glycosylation	R-HSA-5173105	9.977830e-01	0.001
Mitochondrial translation	R-HSA-5368287	9.978697e-01	0.001
Metabolism of proteins	R-HSA-392499	9.982788e-01	0.001
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	9.983231e-01	0.001
Complement cascade	R-HSA-166658	9.984517e-01	0.001
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.987318e-01	0.001
Keratinization	R-HSA-6805567	9.987460e-01	0.001
Arachidonate metabolism	R-HSA-2142753	9.988291e-01	0.001
G alpha (s) signalling events	R-HSA-418555	9.994733e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.995776e-01	0.000
Respiratory electron transport	R-HSA-611105	9.996018e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.996524e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.996868e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.998414e-01	0.000
G alpha (q) signalling events	R-HSA-416476	9.998489e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999624e-01	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	9.999705e-01	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	9.999902e-01	0.000
Phase I - Functionalization of compounds	R-HSA-211945	9.999931e-01	0.000
Fatty acid metabolism	R-HSA-8978868	9.999939e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999942e-01	0.000
Bacterial Infection Pathways	R-HSA-9824439	9.999987e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999990e-01	0.000
Signaling by GPCR	R-HSA-372790	9.999995e-01	0.000
Diseases of metabolism	R-HSA-5668914	9.999997e-01	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Biological oxidations	R-HSA-211859	1.000000e+00	0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Attenuation phase	R-HSA-3371568	1.110223e-16	15.955
HSF1 activation	R-HSA-3371511	1.110223e-16	15.955
HSF1-dependent transactivation	R-HSA-3371571	1.110223e-16	15.955
Cellular response to heat stress	R-HSA-3371556	1.110223e-16	15.955
Cellular responses to stimuli	R-HSA-8953897	1.110223e-16	15.955
Cellular responses to stress	R-HSA-2262752	1.110223e-16	15.955
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	1.332268e-15	14.875
Nervous system development	R-HSA-9675108	1.256772e-13	12.901
Axon guidance	R-HSA-422475	2.604583e-13	12.584
Eukaryotic Translation Elongation	R-HSA-156842	3.406164e-13	12.468
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	1.069944e-11	10.971
Eukaryotic Translation Initiation	R-HSA-72613	1.000000e-11	11.000
Cap-dependent Translation Initiation	R-HSA-72737	1.000000e-11	11.000
Influenza Infection	R-HSA-168255	1.004585e-11	10.998
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	1.275036e-11	10.894
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	2.717049e-11	10.566
Peptide chain elongation	R-HSA-156902	3.831491e-11	10.417
Influenza Viral RNA Transcription and Replication	R-HSA-168273	4.085110e-11	10.389
Signaling by ROBO receptors	R-HSA-376176	4.081990e-11	10.389
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	6.257372e-11	10.204
Nonsense-Mediated Decay (NMD)	R-HSA-927802	1.198829e-10	9.921
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	1.198829e-10	9.921
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.699252e-10	9.770
Formation of a pool of free 40S subunits	R-HSA-72689	1.984284e-10	9.702
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	2.995774e-10	9.523
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	4.159630e-10	9.381
Ribosome-associated quality control	R-HSA-9948299	4.116749e-10	9.385
Aggrephagy	R-HSA-9646399	5.540450e-10	9.256
Eukaryotic Translation Termination	R-HSA-72764	1.152317e-09	8.938
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	2.720972e-09	8.565
Selenocysteine synthesis	R-HSA-2408557	2.984298e-09	8.525
Viral mRNA Translation	R-HSA-192823	4.042426e-09	8.393
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	4.693362e-09	8.329
M Phase	R-HSA-68886	1.236626e-08	7.908
Cell junction organization	R-HSA-446728	1.550943e-08	7.809
Separation of Sister Chromatids	R-HSA-2467813	4.273233e-08	7.369
Metabolism of RNA	R-HSA-8953854	5.979943e-08	7.223
Cell-Cell communication	R-HSA-1500931	8.454781e-08	7.073
Mitotic Anaphase	R-HSA-68882	1.335762e-07	6.874
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.453076e-07	6.838
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	1.684396e-07	6.774
SARS-CoV-1-host interactions	R-HSA-9692914	1.717015e-07	6.765
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	2.195685e-07	6.658
Recycling pathway of L1	R-HSA-437239	2.386769e-07	6.622
Regulation of CDH1 Function	R-HSA-9764561	2.504450e-07	6.601
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	2.789701e-07	6.554
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	2.813376e-07	6.551
Interferon Signaling	R-HSA-913531	2.962932e-07	6.528
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	2.998823e-07	6.523
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	3.214772e-07	6.493
PKR-mediated signaling	R-HSA-9833482	3.342502e-07	6.476
Cell Cycle	R-HSA-1640170	3.671473e-07	6.435
Regulation of CDH1 Expression and Function	R-HSA-9764265	4.234700e-07	6.373
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	4.234700e-07	6.373
rRNA processing in the nucleus and cytosol	R-HSA-8868773	4.542220e-07	6.343
Cell Cycle, Mitotic	R-HSA-69278	4.726086e-07	6.325
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	5.975449e-07	6.224
Mitotic Prometaphase	R-HSA-68877	6.954192e-07	6.158
Translation initiation complex formation	R-HSA-72649	8.963259e-07	6.048
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	9.722698e-07	6.012
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	1.097063e-06	5.960
Selective autophagy	R-HSA-9663891	1.171533e-06	5.931
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.243606e-06	5.905
SARS-CoV-1 Infection	R-HSA-9678108	1.764336e-06	5.753
Developmental Biology	R-HSA-1266738	1.875150e-06	5.727
Cell-cell junction organization	R-HSA-421270	1.938435e-06	5.713
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	1.953705e-06	5.709
Selenoamino acid metabolism	R-HSA-2408522	2.171405e-06	5.663
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	2.919595e-06	5.535
Chaperone Mediated Autophagy	R-HSA-9613829	3.179080e-06	5.498
Translation	R-HSA-72766	3.689740e-06	5.433
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	4.444489e-06	5.352
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	4.415545e-06	5.355
Cellular response to starvation	R-HSA-9711097	4.472237e-06	5.349
rRNA processing	R-HSA-72312	4.594431e-06	5.338
Interleukin-12 signaling	R-HSA-9020591	4.797300e-06	5.319
Adherens junctions interactions	R-HSA-418990	5.162447e-06	5.287
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	5.485996e-06	5.261
Gap junction trafficking	R-HSA-190828	5.645115e-06	5.248
Ribosomal scanning and start codon recognition	R-HSA-72702	7.150020e-06	5.146
FLT3 signaling by CBL mutants	R-HSA-9706377	7.852002e-06	5.105
Apoptotic execution phase	R-HSA-75153	8.003197e-06	5.097
L1CAM interactions	R-HSA-373760	1.140471e-05	4.943
Viral Infection Pathways	R-HSA-9824446	1.159636e-05	4.936
Gap junction trafficking and regulation	R-HSA-157858	1.313791e-05	4.881
G2/M Transition	R-HSA-69275	1.361150e-05	4.866
Cytokine Signaling in Immune system	R-HSA-1280215	1.545685e-05	4.811
Mitotic G2-G2/M phases	R-HSA-453274	1.574488e-05	4.803
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	1.723910e-05	4.763
Interleukin-12 family signaling	R-HSA-447115	2.081899e-05	4.682
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	2.304429e-05	4.637
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	2.327807e-05	4.633
Cellular Senescence	R-HSA-2559583	2.700346e-05	4.569
Transport of connexons to the plasma membrane	R-HSA-190872	3.047238e-05	4.516
Regulation of signaling by CBL	R-HSA-912631	3.976530e-05	4.400
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	4.291131e-05	4.367
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	4.528349e-05	4.344
Activation of AMPK downstream of NMDARs	R-HSA-9619483	5.086662e-05	4.294
Post-chaperonin tubulin folding pathway	R-HSA-389977	5.126574e-05	4.290
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	5.573119e-05	4.254
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	6.661178e-05	4.176
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	7.889515e-05	4.103
Listeria monocytogenes entry into host cells	R-HSA-8876384	8.246298e-05	4.084
Chaperonin-mediated protein folding	R-HSA-390466	8.484711e-05	4.071
Cell-extracellular matrix interactions	R-HSA-446353	9.216387e-05	4.035
Glycolysis	R-HSA-70171	9.630635e-05	4.016
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.144461e-04	3.941
Autophagy	R-HSA-9612973	1.265257e-04	3.898
Josephin domain DUBs	R-HSA-5689877	1.445186e-04	3.840
Apoptosis induced DNA fragmentation	R-HSA-140342	1.445186e-04	3.840
Protein folding	R-HSA-391251	1.528923e-04	3.816
DNA Damage Recognition in GG-NER	R-HSA-5696394	1.539782e-04	3.813
mRNA Splicing - Major Pathway	R-HSA-72163	1.945728e-04	3.711
Maturation of protein E	R-HSA-9683683	2.540528e-04	3.595
Maturation of protein E	R-HSA-9694493	2.540528e-04	3.595
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	2.845942e-04	3.546
Kinesins	R-HSA-983189	2.874353e-04	3.541
ISG15 antiviral mechanism	R-HSA-1169408	3.485534e-04	3.458
mRNA Splicing	R-HSA-72172	3.673710e-04	3.435
Macroautophagy	R-HSA-1632852	3.703361e-04	3.431
VLDLR internalisation and degradation	R-HSA-8866427	3.726713e-04	3.429
p75NTR recruits signalling complexes	R-HSA-209543	3.726713e-04	3.429
Cell Cycle Checkpoints	R-HSA-69620	3.980020e-04	3.400
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	4.869485e-04	3.313
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	4.869485e-04	3.313
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	5.456483e-04	3.263
Glucose metabolism	R-HSA-70326	5.033181e-04	3.298
SARS-CoV-2-host interactions	R-HSA-9705683	5.228264e-04	3.282
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	5.631092e-04	3.249
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	5.920781e-04	3.228
DNA Double Strand Break Response	R-HSA-5693606	6.097265e-04	3.215
Mitotic Prophase	R-HSA-68875	6.255312e-04	3.204
Regulation of PTEN localization	R-HSA-8948747	5.850758e-04	3.233
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	5.911725e-04	3.228
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	6.321629e-04	3.199
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	6.250365e-04	3.204
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	8.037541e-04	3.095
Regulation of CDH1 Gene Transcription	R-HSA-9764560	8.187377e-04	3.087
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	8.187377e-04	3.087
MHC class II antigen presentation	R-HSA-2132295	7.720310e-04	3.112
Spry regulation of FGF signaling	R-HSA-1295596	8.037541e-04	3.095
p75NTR signals via NF-kB	R-HSA-193639	8.037541e-04	3.095
Response of Mtb to phagocytosis	R-HSA-9637690	7.565490e-04	3.121
Generic Transcription Pathway	R-HSA-212436	7.862069e-04	3.104
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	7.406372e-04	3.130
Host Interactions of HIV factors	R-HSA-162909	8.268916e-04	3.083
Formation of annular gap junctions	R-HSA-196025	8.320150e-04	3.080
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	8.320150e-04	3.080
Myoclonic epilepsy of Lafora	R-HSA-3785653	8.320150e-04	3.080
Downregulation of ERBB4 signaling	R-HSA-1253288	8.320150e-04	3.080
Modulation by Mtb of host immune system	R-HSA-9637628	8.320150e-04	3.080
Cargo trafficking to the periciliary membrane	R-HSA-5620920	9.002682e-04	3.046
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	9.870187e-04	3.006
Gap junction assembly	R-HSA-190861	9.870187e-04	3.006
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	9.883442e-04	3.005
Gap junction degradation	R-HSA-190873	1.144590e-03	2.941
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	1.069385e-03	2.971
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	1.144590e-03	2.941
Hedgehog 'off' state	R-HSA-5610787	1.121256e-03	2.950
Post NMDA receptor activation events	R-HSA-438064	1.128991e-03	2.947
Negative regulation of FLT3	R-HSA-9706369	1.007874e-03	2.997
Clathrin-mediated endocytosis	R-HSA-8856828	1.268656e-03	2.897
Non-integrin membrane-ECM interactions	R-HSA-3000171	1.295813e-03	2.887
Oxidative Stress Induced Senescence	R-HSA-2559580	1.300939e-03	2.886
Signaling by EGFR in Cancer	R-HSA-1643713	1.406088e-03	2.852
Apoptosis	R-HSA-109581	1.430102e-03	2.845
Folding of actin by CCT/TriC	R-HSA-390450	1.531367e-03	2.815
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	1.531367e-03	2.815
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.531367e-03	2.815
Pexophagy	R-HSA-9664873	1.531367e-03	2.815
Nucleotide Excision Repair	R-HSA-5696398	1.732082e-03	2.761
Regulation of TP53 Activity through Methylation	R-HSA-6804760	1.852145e-03	2.732
Negative regulation of FGFR3 signaling	R-HSA-5654732	1.902057e-03	2.721
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	1.908361e-03	2.719
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.988099e-03	2.702
Signaling by ALK in cancer	R-HSA-9700206	1.988099e-03	2.702
PECAM1 interactions	R-HSA-210990	2.000854e-03	2.699
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	2.000854e-03	2.699
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	2.223534e-03	2.653
Translesion Synthesis by POLH	R-HSA-110320	2.223534e-03	2.653
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	2.388842e-03	2.622
Termination of translesion DNA synthesis	R-HSA-5656169	2.194786e-03	2.659
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	2.127276e-03	2.672
Negative regulation of FGFR4 signaling	R-HSA-5654733	2.194786e-03	2.659
Gene expression (Transcription)	R-HSA-74160	2.334590e-03	2.632
Downregulation of ERBB2 signaling	R-HSA-8863795	2.520249e-03	2.599
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	2.561428e-03	2.592
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	2.561428e-03	2.592
NF-kB is activated and signals survival	R-HSA-209560	2.561428e-03	2.592
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	2.601595e-03	2.585
Negative regulation of MET activity	R-HSA-6807004	2.646382e-03	2.577
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	3.124619e-03	2.505
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	2.880671e-03	2.541
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	3.078363e-03	2.512
Amplification of signal from the kinetochores	R-HSA-141424	3.151695e-03	2.501
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	3.151695e-03	2.501
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	2.711346e-03	2.567
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	3.124619e-03	2.505
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	3.221275e-03	2.492
HIV Infection	R-HSA-162906	2.743240e-03	2.562
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	2.880671e-03	2.541
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	3.221275e-03	2.492
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	3.221275e-03	2.492
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	2.801308e-03	2.553
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	3.221275e-03	2.492
IRAK1 recruits IKK complex	R-HSA-937039	3.221275e-03	2.492
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	2.986247e-03	2.525
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	3.324746e-03	2.478
Nuclear Envelope Breakdown	R-HSA-2980766	3.376275e-03	2.472
Mitotic Spindle Checkpoint	R-HSA-69618	3.420584e-03	2.466
SARS-CoV-2 Infection	R-HSA-9694516	3.471135e-03	2.460
Developmental Lineages of the Mammary Gland	R-HSA-9924644	3.476876e-03	2.459
SARS-CoV Infections	R-HSA-9679506	3.582595e-03	2.446
Pyruvate metabolism	R-HSA-70268	3.647196e-03	2.438
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	3.662182e-03	2.436
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	3.662182e-03	2.436
Assembly Of The HIV Virion	R-HSA-175474	3.662182e-03	2.436
Cyclin D associated events in G1	R-HSA-69231	3.691739e-03	2.433
G1 Phase	R-HSA-69236	3.691739e-03	2.433
Negative regulation of FGFR1 signaling	R-HSA-5654726	3.715456e-03	2.430
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	4.834526e-03	2.316
Dual Incision in GG-NER	R-HSA-5696400	4.717495e-03	2.326
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	4.517219e-03	2.345
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	4.399930e-03	2.357
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	4.870233e-03	2.312
Membrane binding and targetting of GAG proteins	R-HSA-174490	3.988329e-03	2.399
mTORC1-mediated signalling	R-HSA-166208	4.263000e-03	2.370
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	4.870233e-03	2.312
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	4.434379e-03	2.353
NRIF signals cell death from the nucleus	R-HSA-205043	4.870233e-03	2.312
Negative regulation of FGFR2 signaling	R-HSA-5654727	4.717495e-03	2.326
MAP kinase activation	R-HSA-450294	4.797364e-03	2.319
Signaling by ERBB2	R-HSA-1227986	4.405550e-03	2.356
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	3.901260e-03	2.409
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	4.263000e-03	2.370
RNA Polymerase II Transcription	R-HSA-73857	3.920297e-03	2.407
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	4.978753e-03	2.303
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	4.978753e-03	2.303
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	5.215344e-03	2.283
Regulation of Apoptosis	R-HSA-169911	5.287034e-03	2.277
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	5.287034e-03	2.277
Oncogene Induced Senescence	R-HSA-2559585	5.287034e-03	2.277
Programmed Cell Death	R-HSA-5357801	5.299884e-03	2.276
Infectious disease	R-HSA-5663205	5.354246e-03	2.271
Gluconeogenesis	R-HSA-70263	5.474872e-03	2.262
Estrogen-dependent gene expression	R-HSA-9018519	5.533969e-03	2.257
DNA Double-Strand Break Repair	R-HSA-5693532	5.592157e-03	2.252
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	5.660592e-03	2.247
Loss of Nlp from mitotic centrosomes	R-HSA-380259	5.660592e-03	2.247
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	5.669950e-03	2.246
Manipulation of host energy metabolism	R-HSA-9636667	5.755376e-03	2.240
Sema3A PAK dependent Axon repulsion	R-HSA-399954	5.874292e-03	2.231
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	5.874292e-03	2.231
Translesion synthesis by REV1	R-HSA-110312	5.874292e-03	2.231
Protein methylation	R-HSA-8876725	5.874292e-03	2.231
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	5.874292e-03	2.231
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	5.874292e-03	2.231
Regulation of TP53 Degradation	R-HSA-6804757	5.905355e-03	2.229
FLT3 signaling in disease	R-HSA-9682385	5.905355e-03	2.229
Cilium Assembly	R-HSA-5617833	5.953478e-03	2.225
DNA Damage Bypass	R-HSA-73893	6.007127e-03	2.221
Degradation of CDH1	R-HSA-9766229	6.007127e-03	2.221
Signaling by Hedgehog	R-HSA-5358351	6.136402e-03	2.212
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	6.574778e-03	2.182
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	6.574778e-03	2.182
HIV Life Cycle	R-HSA-162587	6.776991e-03	2.169
Translesion synthesis by POLI	R-HSA-5656121	7.007444e-03	2.154
Regulation of NF-kappa B signaling	R-HSA-9758274	7.007444e-03	2.154
Regulation of BACH1 activity	R-HSA-9708530	7.007444e-03	2.154
Signaling by Interleukins	R-HSA-449147	7.010834e-03	2.154
AURKA Activation by TPX2	R-HSA-8854518	7.171083e-03	2.144
Translesion synthesis by POLK	R-HSA-5655862	8.276232e-03	2.082
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	8.528717e-03	2.069
Neutrophil degranulation	R-HSA-6798695	7.760885e-03	2.110
COPI-mediated anterograde transport	R-HSA-6807878	7.575179e-03	2.121
Degradation of beta-catenin by the destruction complex	R-HSA-195253	9.634877e-03	2.016
Orc1 removal from chromatin	R-HSA-68949	7.836312e-03	2.106
Hh mutants are degraded by ERAD	R-HSA-5362768	9.809392e-03	2.008
Oncogenic MAPK signaling	R-HSA-6802957	8.907057e-03	2.050
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	9.809392e-03	2.008
Regulation of FZD by ubiquitination	R-HSA-4641263	9.686778e-03	2.014
G2/M Checkpoints	R-HSA-69481	7.821016e-03	2.107
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	8.276232e-03	2.082
Smooth Muscle Contraction	R-HSA-445355	8.528717e-03	2.069
Stabilization of p53	R-HSA-69541	8.076154e-03	2.093
Platelet degranulation	R-HSA-114608	7.821016e-03	2.107
Interleukin-17 signaling	R-HSA-448424	9.634877e-03	2.016
Signaling by TGF-beta Receptor Complex	R-HSA-170834	8.051118e-03	2.094
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	7.376056e-03	2.132
Regulation of TP53 Expression and Degradation	R-HSA-6806003	8.076154e-03	2.093
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	8.276232e-03	2.082
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	7.836312e-03	2.106
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	8.276232e-03	2.082
Glycogen storage diseases	R-HSA-3229121	9.686778e-03	2.014
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	9.985048e-03	2.001
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	9.985048e-03	2.001
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	9.985048e-03	2.001
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	9.985048e-03	2.001
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	9.985048e-03	2.001
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	9.985048e-03	2.001
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	9.985048e-03	2.001
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	9.985048e-03	2.001
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	9.985048e-03	2.001
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	9.985048e-03	2.001
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	9.985048e-03	2.001
Late endosomal microautophagy	R-HSA-9615710	1.056012e-02	1.976
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.056012e-02	1.976
Signaling by CSF3 (G-CSF)	R-HSA-9674555	1.056012e-02	1.976
Golgi-to-ER retrograde transport	R-HSA-8856688	1.057516e-02	1.976
Degradation of GLI1 by the proteasome	R-HSA-5610780	1.076853e-02	1.968
Negative regulation of MAPK pathway	R-HSA-5675221	1.076853e-02	1.968
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	1.087569e-02	1.964
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	1.109914e-02	1.955
Ephrin signaling	R-HSA-3928664	1.124477e-02	1.949
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	1.179225e-02	1.928
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.185968e-02	1.926
Switching of origins to a post-replicative state	R-HSA-69052	1.185968e-02	1.926
Dual incision in TC-NER	R-HSA-6782135	1.268041e-02	1.897
Hh mutants abrogate ligand secretion	R-HSA-5387390	1.288267e-02	1.890
Signaling by FGFR4	R-HSA-5654743	1.288267e-02	1.890
IKK complex recruitment mediated by RIP1	R-HSA-937041	1.295545e-02	1.888
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	1.307080e-02	1.884
EGFR downregulation	R-HSA-182971	1.313940e-02	1.881
Budding and maturation of HIV virion	R-HSA-162588	1.313940e-02	1.881
Centrosome maturation	R-HSA-380287	1.353923e-02	1.868
EPHB-mediated forward signaling	R-HSA-3928662	1.404186e-02	1.853
UCH proteinases	R-HSA-5689603	1.444124e-02	1.840
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	1.457556e-02	1.836
Apoptotic cleavage of cellular proteins	R-HSA-111465	1.457556e-02	1.836
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.469114e-02	1.833
Glycogen synthesis	R-HSA-3322077	1.482359e-02	1.829
Defective CFTR causes cystic fibrosis	R-HSA-5678895	1.527182e-02	1.816
Signaling by FGFR3	R-HSA-5654741	1.527182e-02	1.816
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	1.527182e-02	1.816
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	1.527182e-02	1.816
EPH-Ephrin signaling	R-HSA-2682334	1.537673e-02	1.813
Regulation of necroptotic cell death	R-HSA-5675482	1.611330e-02	1.793
Assembly of the pre-replicative complex	R-HSA-68867	1.626538e-02	1.789
HCMV Early Events	R-HSA-9609690	1.632248e-02	1.787
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	1.657452e-02	1.781
Signaling downstream of RAS mutants	R-HSA-9649948	1.657452e-02	1.781
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.657452e-02	1.781
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.657452e-02	1.781
Signaling by RAS mutants	R-HSA-6802949	1.657452e-02	1.781
Regulation of pyruvate metabolism	R-HSA-9861718	1.657452e-02	1.781
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	1.685352e-02	1.773
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	1.685352e-02	1.773
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	1.685352e-02	1.773
Striated Muscle Contraction	R-HSA-390522	1.775538e-02	1.751
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	1.775538e-02	1.751
Vpu mediated degradation of CD4	R-HSA-180534	1.775538e-02	1.751
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	1.795184e-02	1.746
Late Phase of HIV Life Cycle	R-HSA-162599	1.827325e-02	1.738
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	1.827325e-02	1.738
Signaling by FGFR2	R-HSA-5654738	1.848922e-02	1.733
Intraflagellar transport	R-HSA-5620924	1.940561e-02	1.712
Nuclear import of Rev protein	R-HSA-180746	1.950438e-02	1.710
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	1.950438e-02	1.710
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	1.950438e-02	1.710
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	2.843303e-02	1.546
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	2.247568e-02	1.648
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	2.624465e-02	1.581
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	3.033031e-02	1.518
Deadenylation of mRNA	R-HSA-429947	2.666106e-02	1.574
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	2.136272e-02	1.670
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	2.601900e-02	1.585
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	2.601900e-02	1.585
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	2.787971e-02	1.555
Regulation of endogenous retroelements	R-HSA-9842860	2.732220e-02	1.563
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	2.601900e-02	1.585
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	2.992362e-02	1.524
Regulation of mitotic cell cycle	R-HSA-453276	2.992362e-02	1.524
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	2.329079e-02	1.633
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	2.136272e-02	1.670
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	2.136272e-02	1.670
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	2.541624e-02	1.595
Developmental Cell Lineages	R-HSA-9734767	2.101550e-02	1.677
ER to Golgi Anterograde Transport	R-HSA-199977	2.249498e-02	1.648
Ovarian tumor domain proteases	R-HSA-5689896	2.541624e-02	1.595
Degradation of DVL	R-HSA-4641258	2.541624e-02	1.595
Vif-mediated degradation of APOBEC3G	R-HSA-180585	2.333264e-02	1.632
Degradation of AXIN	R-HSA-4641257	2.541624e-02	1.595
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	2.541624e-02	1.595
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	2.982619e-02	1.525
Regulation of PTEN stability and activity	R-HSA-8948751	2.787971e-02	1.555
S Phase	R-HSA-69242	2.341921e-02	1.630
Membrane Trafficking	R-HSA-199991	2.856677e-02	1.544
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	2.993184e-02	1.524
Response of endothelial cells to shear stress	R-HSA-9860931	3.004684e-02	1.522
Regulation of KIT signaling	R-HSA-1433559	3.033031e-02	1.518
NS1 Mediated Effects on Host Pathways	R-HSA-168276	2.993184e-02	1.524
RIPK1-mediated regulated necrosis	R-HSA-5213460	2.761540e-02	1.559
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	2.141365e-02	1.669
p53-Dependent G1 DNA Damage Response	R-HSA-69563	2.093757e-02	1.679
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	2.093757e-02	1.679
Hedgehog ligand biogenesis	R-HSA-5358346	2.424271e-02	1.615
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	2.666106e-02	1.574
Neurodegenerative Diseases	R-HSA-8863678	2.666106e-02	1.574
KEAP1-NFE2L2 pathway	R-HSA-9755511	2.635961e-02	1.579
Plasma lipoprotein clearance	R-HSA-8964043	2.993184e-02	1.524
Homology Directed Repair	R-HSA-5693538	2.784750e-02	1.555
Interferon alpha/beta signaling	R-HSA-909733	2.433924e-02	1.614
Nuclear events mediated by NFE2L2	R-HSA-9759194	3.170183e-02	1.499
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	3.185969e-02	1.497
Signaling by NOTCH3	R-HSA-9012852	3.185969e-02	1.497
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	3.191071e-02	1.496
Formation of Incision Complex in GG-NER	R-HSA-5696395	3.236712e-02	1.490
Interactions of Rev with host cellular proteins	R-HSA-177243	3.236712e-02	1.490
Regulation of RUNX3 expression and activity	R-HSA-8941858	3.236712e-02	1.490
Negative regulation of NOTCH4 signaling	R-HSA-9604323	3.236712e-02	1.490
Metalloprotease DUBs	R-HSA-5689901	3.261368e-02	1.487
Myogenesis	R-HSA-525793	3.261368e-02	1.487
Suppression of phagosomal maturation	R-HSA-9637687	3.261368e-02	1.487
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	3.368959e-02	1.473
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	3.398139e-02	1.469
Signaling by FGFR1	R-HSA-5654736	3.398139e-02	1.469
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	3.473038e-02	1.459
VEGFR2 mediated vascular permeability	R-HSA-5218920	3.492257e-02	1.457
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	3.492257e-02	1.457
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	3.492257e-02	1.457
FLT3 Signaling	R-HSA-9607240	3.492257e-02	1.457
Signaling by NOTCH4	R-HSA-9013694	3.543904e-02	1.451
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	3.585810e-02	1.445
ER Quality Control Compartment (ERQC)	R-HSA-901032	3.585810e-02	1.445
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	3.585810e-02	1.445
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	3.585810e-02	1.445
Synthesis of DNA	R-HSA-69239	3.605402e-02	1.443
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	3.625266e-02	1.441
Regulation of CDH19 Expression and Function	R-HSA-9764302	3.625266e-02	1.441
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	3.645597e-02	1.438
Signaling by RAF1 mutants	R-HSA-9656223	3.759939e-02	1.425
MAP2K and MAPK activation	R-HSA-5674135	3.759939e-02	1.425
Degradation of CRY and PER proteins	R-HSA-9932298	3.759939e-02	1.425
Degradation of GLI2 by the proteasome	R-HSA-5610783	3.759939e-02	1.425
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	3.759939e-02	1.425
Translation of Structural Proteins	R-HSA-9683701	3.759939e-02	1.425
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	3.928235e-02	1.406
DNA Replication Pre-Initiation	R-HSA-69002	3.934633e-02	1.405
MTOR signalling	R-HSA-165159	4.039856e-02	1.394
Peroxisomal protein import	R-HSA-9033241	4.088594e-02	1.388
TCR signaling	R-HSA-202403	4.106663e-02	1.387
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	4.288674e-02	1.368
Regulation of CDH11 Expression and Function	R-HSA-9759475	4.288674e-02	1.368
PCP/CE pathway	R-HSA-4086400	4.378283e-02	1.359
Nef and signal transduction	R-HSA-164944	4.479315e-02	1.349
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	4.480357e-02	1.349
Viral Messenger RNA Synthesis	R-HSA-168325	4.594717e-02	1.338
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	4.636702e-02	1.334
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	4.667120e-02	1.331
HCMV Infection	R-HSA-9609646	4.820132e-02	1.317
Signaling by MET	R-HSA-6806834	4.839196e-02	1.315
Cellular responses to mechanical stimuli	R-HSA-9855142	4.845374e-02	1.315
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	4.861734e-02	1.313
DNA Repair	R-HSA-73894	4.908530e-02	1.309
Asymmetric localization of PCP proteins	R-HSA-4608870	4.953739e-02	1.305
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	4.953739e-02	1.305
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	5.063525e-02	1.296
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	5.063525e-02	1.296
Evasion by RSV of host interferon responses	R-HSA-9833109	5.063525e-02	1.296
Processing of DNA double-strand break ends	R-HSA-5693607	5.080786e-02	1.294
G1/S DNA Damage Checkpoints	R-HSA-69615	5.138125e-02	1.289
Signaling by PTK6	R-HSA-8848021	5.138125e-02	1.289
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	5.138125e-02	1.289
Regulation of TNFR1 signaling	R-HSA-5357905	5.283228e-02	1.277
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	5.283228e-02	1.277
Signaling by FGFR	R-HSA-190236	5.341399e-02	1.272
MyD88 cascade initiated on plasma membrane	R-HSA-975871	5.341399e-02	1.272
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	5.341399e-02	1.272
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	5.341399e-02	1.272
Cohesin Loading onto Chromatin	R-HSA-2470946	5.399174e-02	1.268
CHL1 interactions	R-HSA-447041	5.399174e-02	1.268
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	5.399174e-02	1.268
Uptake and function of diphtheria toxin	R-HSA-5336415	5.399174e-02	1.268
VEGFA-VEGFR2 Pathway	R-HSA-4420097	5.453742e-02	1.263
Depolymerization of the Nuclear Lamina	R-HSA-4419969	5.539046e-02	1.257
DNA Replication	R-HSA-69306	5.782273e-02	1.238
IPs transport between nucleus and cytosol	R-HSA-1855170	5.909849e-02	1.228
Transport of the SLBP independent Mature mRNA	R-HSA-159227	5.909849e-02	1.228
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	5.909849e-02	1.228
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	5.979586e-02	1.223
MAPK6/MAPK4 signaling	R-HSA-5687128	6.122353e-02	1.213
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	6.129115e-02	1.213
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	6.346423e-02	1.197
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	6.346423e-02	1.197
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	6.359499e-02	1.197
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	6.359499e-02	1.197
Type I hemidesmosome assembly	R-HSA-446107	6.378927e-02	1.195
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	6.378927e-02	1.195
Regulation of RAS by GAPs	R-HSA-5658442	6.725651e-02	1.172
Co-inhibition by CTLA4	R-HSA-389513	6.747171e-02	1.171
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	6.747171e-02	1.171
Formation of definitive endoderm	R-HSA-9823730	6.747171e-02	1.171
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	6.747171e-02	1.171
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	6.826576e-02	1.166
NOD1/2 Signaling Pathway	R-HSA-168638	6.826576e-02	1.166
Calnexin/calreticulin cycle	R-HSA-901042	6.826576e-02	1.166
Signaling by NOTCH2	R-HSA-1980145	6.826576e-02	1.166
Mitophagy	R-HSA-5205647	6.826576e-02	1.166
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	6.904272e-02	1.161
PTEN Regulation	R-HSA-6807070	6.946071e-02	1.158
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	7.117214e-02	1.148
Activation of NF-kappaB in B cells	R-HSA-1169091	7.117214e-02	1.148
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	7.158504e-02	1.145
SARS-CoV-1 targets PDZ proteins in cell-cell junction	R-HSA-9692912	7.158504e-02	1.145
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	1.054354e-01	0.977
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	1.380536e-01	0.860
ALK mutants bind TKIs	R-HSA-9700645	7.412999e-02	1.130
Binding and entry of HIV virion	R-HSA-173107	8.496144e-02	1.071
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	8.496144e-02	1.071
Signaling by GSK3beta mutants	R-HSA-5339716	1.079019e-01	0.967
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	1.199208e-01	0.921
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	1.199208e-01	0.921
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	1.199208e-01	0.921
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	1.199208e-01	0.921
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	1.199208e-01	0.921
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	1.322499e-01	0.879
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	9.481991e-02	1.023
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	9.481991e-02	1.023
Tight junction interactions	R-HSA-420029	1.099376e-01	0.959
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	1.259108e-01	0.900
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	1.259108e-01	0.900
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	1.341922e-01	0.872
Formation of the Early Elongation Complex	R-HSA-113418	1.341922e-01	0.872
HIV elongation arrest and recovery	R-HSA-167287	1.341922e-01	0.872
Pausing and recovery of HIV elongation	R-HSA-167290	1.341922e-01	0.872
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	9.414953e-02	1.026
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	9.981189e-02	1.001
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	7.937039e-02	1.100
mRNA Splicing - Minor Pathway	R-HSA-72165	1.435388e-01	0.843
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	1.117964e-01	0.952
Protein ubiquitination	R-HSA-8852135	9.191285e-02	1.037
mRNA Capping	R-HSA-72086	1.426561e-01	0.846
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	7.689594e-02	1.114
Regulation of CDH11 function	R-HSA-9762292	8.496144e-02	1.071
ATP-dependent chromatin remodelers	R-HSA-9932444	1.099376e-01	0.959
SWI/SNF chromatin remodelers	R-HSA-9932451	1.099376e-01	0.959
Early Phase of HIV Life Cycle	R-HSA-162594	7.392385e-02	1.131
Formation of axial mesoderm	R-HSA-9796292	1.322499e-01	0.879
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	1.368829e-01	0.864
Nucleosome assembly	R-HSA-774815	1.368829e-01	0.864
Formation of the posterior neural plate	R-HSA-9832991	9.623423e-02	1.017
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	1.079019e-01	0.967
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	1.322499e-01	0.879
Lysosome Vesicle Biogenesis	R-HSA-432720	7.812128e-02	1.107
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	1.322499e-01	0.879
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	1.380536e-01	0.860
Unwinding of DNA	R-HSA-176974	7.412999e-02	1.130
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.079019e-01	0.967
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.199208e-01	0.921
Vpr-mediated nuclear import of PICs	R-HSA-180910	8.330095e-02	1.079
Interaction between L1 and Ankyrins	R-HSA-445095	1.259108e-01	0.900
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	1.368829e-01	0.864
Signaling by EGFR	R-HSA-177929	9.256998e-02	1.034
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	1.341922e-01	0.872
Maternal to zygotic transition (MZT)	R-HSA-9816359	7.310938e-02	1.136
Fanconi Anemia Pathway	R-HSA-6783310	1.368829e-01	0.864
Transcriptional regulation by small RNAs	R-HSA-5578749	8.051039e-02	1.094
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	1.405875e-01	0.852
Transport to the Golgi and subsequent modification	R-HSA-948021	1.259441e-01	0.900
Platelet Adhesion to exposed collagen	R-HSA-75892	1.322499e-01	0.879
rRNA modification in the nucleus and cytosol	R-HSA-6790901	1.273757e-01	0.895
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	1.216868e-01	0.915
Signaling by VEGF	R-HSA-194138	8.097014e-02	1.092
Integration of provirus	R-HSA-162592	1.079019e-01	0.967
Breakdown of the nuclear lamina	R-HSA-352238	1.054354e-01	0.977
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	8.226724e-02	1.085
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	8.833999e-02	1.054
MyD88-independent TLR4 cascade	R-HSA-166166	8.833999e-02	1.054
Regulation of T cell activation by CD28 family	R-HSA-388841	9.524580e-02	1.021
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	7.363571e-02	1.133
TNF signaling	R-HSA-75893	9.256998e-02	1.034
Basigin interactions	R-HSA-210991	7.392385e-02	1.131
Generation of second messenger molecules	R-HSA-202433	9.981189e-02	1.001
Suppression of apoptosis	R-HSA-9635465	9.623423e-02	1.017
tRNA processing in the nucleus	R-HSA-6784531	1.220762e-01	0.913
MyD88 dependent cascade initiated on endosome	R-HSA-975155	8.527183e-02	1.069
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	1.262149e-01	0.899
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	1.368829e-01	0.864
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	1.262149e-01	0.899
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	1.378154e-01	0.861
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	8.496144e-02	1.071
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	1.079019e-01	0.967
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	9.414953e-02	1.026
Interactions of Vpr with host cellular proteins	R-HSA-176033	9.981189e-02	1.001
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	1.056283e-01	0.976
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	1.378154e-01	0.861
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	9.792416e-02	1.009
Muscle contraction	R-HSA-397014	9.650925e-02	1.015
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	1.080727e-01	0.966
Regulation of RUNX2 expression and activity	R-HSA-8939902	1.168823e-01	0.932
RAF/MAP kinase cascade	R-HSA-5673001	1.179967e-01	0.928
Transcriptional regulation by RUNX3	R-HSA-8878159	1.110879e-01	0.954
G1/S Transition	R-HSA-69206	8.097014e-02	1.092
Signaling by TGFB family members	R-HSA-9006936	1.310815e-01	0.882
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.199208e-01	0.921
MAPK1/MAPK3 signaling	R-HSA-5684996	1.348532e-01	0.870
Intracellular signaling by second messengers	R-HSA-9006925	8.653907e-02	1.063
Regulation of CDH11 gene transcription	R-HSA-9762293	7.412999e-02	1.130
Transcriptional regulation by RUNX2	R-HSA-8878166	1.262149e-01	0.899
Organelle biogenesis and maintenance	R-HSA-1852241	1.364562e-01	0.865
Mitotic G1 phase and G1/S transition	R-HSA-453279	8.920824e-02	1.050
Signaling by NOTCH1	R-HSA-1980143	9.589803e-02	1.018
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.303561e-01	0.885
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	7.412999e-02	1.130
Respiratory syncytial virus genome replication	R-HSA-9834752	7.412999e-02	1.130
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	1.079019e-01	0.967
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	9.481991e-02	1.023
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	8.864476e-02	1.052
Cyclin E associated events during G1/S transition	R-HSA-69202	7.337548e-02	1.134
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	7.337548e-02	1.134
Cellular response to hypoxia	R-HSA-1234174	1.382832e-01	0.859
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	1.327789e-01	0.877
Hedgehog 'on' state	R-HSA-5632684	7.689594e-02	1.114
DAG and IP3 signaling	R-HSA-1489509	1.368829e-01	0.864
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.041404e-01	0.982
ABC transporter disorders	R-HSA-5619084	1.041404e-01	0.982
Immune System	R-HSA-168256	1.028398e-01	0.988
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	8.051039e-02	1.094
Semaphorin interactions	R-HSA-373755	1.273757e-01	0.895
Cellular response to chemical stress	R-HSA-9711123	1.227235e-01	0.911
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	8.063879e-02	1.093
Syndecan interactions	R-HSA-3000170	9.481991e-02	1.023
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	1.322499e-01	0.879
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	1.241165e-01	0.906
Replication of the SARS-CoV-1 genome	R-HSA-9682706	1.322499e-01	0.879
Infection with Mycobacterium tuberculosis	R-HSA-9635486	1.338903e-01	0.873
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	1.012447e-01	0.995
Glycogen metabolism	R-HSA-8982491	9.981189e-02	1.001
Unfolded Protein Response (UPR)	R-HSA-381119	1.311294e-01	0.882
RAS processing	R-HSA-9648002	9.414953e-02	1.026
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	1.448508e-01	0.839
MAPK family signaling cascades	R-HSA-5683057	1.448703e-01	0.839
XBP1(S) activates chaperone genes	R-HSA-381038	1.455143e-01	0.837
Vesicle-mediated transport	R-HSA-5653656	1.455757e-01	0.837
HDR through Homologous Recombination (HRR)	R-HSA-5685942	1.495861e-01	0.825
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	1.503194e-01	0.823
Regulated Necrosis	R-HSA-5218859	1.553796e-01	0.809
Chromatin modifying enzymes	R-HSA-3247509	1.562264e-01	0.806
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.572198e-01	0.803
Co-stimulation by CD28	R-HSA-389356	1.572198e-01	0.803
Beta-catenin phosphorylation cascade	R-HSA-196299	1.576873e-01	0.802
Formation of the anterior neural plate	R-HSA-9823739	1.576873e-01	0.802
IRF3-mediated induction of type I IFN	R-HSA-3270619	1.576873e-01	0.802
DCC mediated attractive signaling	R-HSA-418885	1.576873e-01	0.802
Gene Silencing by RNA	R-HSA-211000	1.580039e-01	0.801
ER-Phagosome pathway	R-HSA-1236974	1.607548e-01	0.794
MITF-M-regulated melanocyte development	R-HSA-9730414	1.631219e-01	0.787
ESR-mediated signaling	R-HSA-8939211	1.656088e-01	0.781
Downstream TCR signaling	R-HSA-202424	1.659829e-01	0.780
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	1.667847e-01	0.778
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	1.672378e-01	0.777
DNA strand elongation	R-HSA-69190	1.690379e-01	0.772
MET interacts with TNS proteins	R-HSA-8875513	1.694844e-01	0.771
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	1.707256e-01	0.768
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	1.732971e-01	0.761
Signaling by NOTCH	R-HSA-157118	1.752703e-01	0.756
IRE1alpha activates chaperones	R-HSA-381070	1.766506e-01	0.753
MITF-M-dependent gene expression	R-HSA-9856651	1.773493e-01	0.751
Regulation of PD-L1(CD274) expression	R-HSA-9909648	1.778674e-01	0.750
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	1.781270e-01	0.749
Activation of ATR in response to replication stress	R-HSA-176187	1.781270e-01	0.749
trans-Golgi Network Vesicle Budding	R-HSA-199992	1.794396e-01	0.746
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	1.839339e-01	0.735
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	1.839339e-01	0.735
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.856623e-01	0.731
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.856623e-01	0.731
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	1.873465e-01	0.727
Protein localization	R-HSA-9609507	1.899384e-01	0.721
G2/M DNA damage checkpoint	R-HSA-69473	1.919626e-01	0.717
Signaling by ERBB4	R-HSA-1236394	1.919626e-01	0.717
Golgi Associated Vesicle Biogenesis	R-HSA-432722	1.933536e-01	0.714
Co-inhibition by PD-1	R-HSA-389948	1.961933e-01	0.707
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	1.966864e-01	0.706
Signaling by EGFRvIII in Cancer	R-HSA-5637812	1.972827e-01	0.705
Constitutive Signaling by EGFRvIII	R-HSA-5637810	1.972827e-01	0.705
Signaling by Hippo	R-HSA-2028269	1.972827e-01	0.705
Specification of primordial germ cells	R-HSA-9827857	1.972827e-01	0.705
Replication of the SARS-CoV-2 genome	R-HSA-9694686	1.972827e-01	0.705
Iron uptake and transport	R-HSA-917937	1.983374e-01	0.703
PIP3 activates AKT signaling	R-HSA-1257604	1.993910e-01	0.700
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	1.997708e-01	0.699
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	1.997708e-01	0.699
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	1.997796e-01	0.699
Chromatin organization	R-HSA-4839726	2.058469e-01	0.686
HDACs deacetylate histones	R-HSA-3214815	2.084773e-01	0.681
Platelet activation, signaling and aggregation	R-HSA-76002	2.094125e-01	0.679
RNA Polymerase III Transcription Termination	R-HSA-73980	2.107441e-01	0.676
Platelet sensitization by LDL	R-HSA-432142	2.107441e-01	0.676
Signaling by ERBB2 ECD mutants	R-HSA-9665348	2.107441e-01	0.676
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	2.107441e-01	0.676
Metabolism of amino acids and derivatives	R-HSA-71291	2.111699e-01	0.675
Translation of Structural Proteins	R-HSA-9694635	2.112990e-01	0.675
Beta-catenin independent WNT signaling	R-HSA-3858494	2.126782e-01	0.672
RUNX2 regulates bone development	R-HSA-8941326	2.156871e-01	0.666
Calmodulin induced events	R-HSA-111933	2.156871e-01	0.666
CaM pathway	R-HSA-111997	2.156871e-01	0.666
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	2.161630e-01	0.665
E2F mediated regulation of DNA replication	R-HSA-113510	2.242924e-01	0.649
Signaling by FGFR2 IIIa TM	R-HSA-8851708	2.242924e-01	0.649
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	2.242924e-01	0.649
STING mediated induction of host immune responses	R-HSA-1834941	2.242924e-01	0.649
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	2.242924e-01	0.649
p75 NTR receptor-mediated signalling	R-HSA-193704	2.277826e-01	0.642
IRS activation	R-HSA-74713	2.289546e-01	0.640
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.289546e-01	0.640
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	2.289546e-01	0.640
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	2.289546e-01	0.640
Nectin/Necl trans heterodimerization	R-HSA-420597	2.289546e-01	0.640
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	2.289546e-01	0.640
ABC-family proteins mediated transport	R-HSA-382556	2.337409e-01	0.631
Protein hydroxylation	R-HSA-9629569	2.379032e-01	0.624
Creatine metabolism	R-HSA-71288	2.379032e-01	0.624
Signal transduction by L1	R-HSA-445144	2.379032e-01	0.624
Amyloid fiber formation	R-HSA-977225	2.379870e-01	0.623
Deadenylation-dependent mRNA decay	R-HSA-429914	2.396566e-01	0.620
Metabolism of non-coding RNA	R-HSA-194441	2.396566e-01	0.620
snRNP Assembly	R-HSA-191859	2.396566e-01	0.620
Interleukin-1 signaling	R-HSA-9020702	2.397473e-01	0.620
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	2.448008e-01	0.611
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	2.448464e-01	0.611
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	2.448464e-01	0.611
RAB geranylgeranylation	R-HSA-8873719	2.476170e-01	0.606
Regulation of PTEN gene transcription	R-HSA-8943724	2.476170e-01	0.606
Sphingolipid de novo biosynthesis	R-HSA-1660661	2.476170e-01	0.606
Signaling by NOTCH1 in Cancer	R-HSA-2644603	2.476170e-01	0.606
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	2.476170e-01	0.606
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	2.476170e-01	0.606
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	2.476170e-01	0.606
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	2.476170e-01	0.606
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	2.483825e-01	0.605
ERK/MAPK targets	R-HSA-198753	2.515542e-01	0.599
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	2.515542e-01	0.599
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	2.516653e-01	0.599
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	2.547045e-01	0.594
HIV Transcription Elongation	R-HSA-167169	2.547045e-01	0.594
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	2.547045e-01	0.594
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	2.547045e-01	0.594
Innate Immune System	R-HSA-168249	2.558272e-01	0.592
Plus-strand DNA synthesis	R-HSA-164525	2.570758e-01	0.590
Noncanonical activation of NOTCH3	R-HSA-9017802	2.570758e-01	0.590
Aryl hydrocarbon receptor signalling	R-HSA-8937144	2.570758e-01	0.590
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	2.570758e-01	0.590
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	2.646170e-01	0.577
Resolution of Abasic Sites (AP sites)	R-HSA-73933	2.646170e-01	0.577
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	2.652242e-01	0.576
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	2.652242e-01	0.576
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	2.652242e-01	0.576
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	2.652242e-01	0.576
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	2.652242e-01	0.576
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	2.783569e-01	0.555
FGFR2 alternative splicing	R-HSA-6803529	2.788939e-01	0.555
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	2.788939e-01	0.555
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	2.788939e-01	0.555
Signaling by KIT in disease	R-HSA-9669938	2.788939e-01	0.555
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	2.788939e-01	0.555
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	2.795701e-01	0.554
Signaling by LTK in cancer	R-HSA-9842640	2.841731e-01	0.546
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	2.841731e-01	0.546
Erythropoietin activates STAT5	R-HSA-9027283	2.841731e-01	0.546
Uncoating of the HIV Virion	R-HSA-162585	2.841731e-01	0.546
H139Hfs13* PPM1K causes a mild variant of MSUD	R-HSA-9912529	2.841731e-01	0.546
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	2.841731e-01	0.546
Ca-dependent events	R-HSA-111996	2.845711e-01	0.546
Antigen processing-Cross presentation	R-HSA-1236975	2.892781e-01	0.539
Stimuli-sensing channels	R-HSA-2672351	2.892781e-01	0.539
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	2.922858e-01	0.534
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	2.925450e-01	0.534
Diseases of programmed cell death	R-HSA-9645723	2.937487e-01	0.532
Signaling by SCF-KIT	R-HSA-1433557	2.945963e-01	0.531
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	2.964009e-01	0.528
Epigenetic regulation of gene expression	R-HSA-212165	2.970108e-01	0.527
RMTs methylate histone arginines	R-HSA-3214858	3.046430e-01	0.516
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	3.061609e-01	0.514
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	3.061609e-01	0.514
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	3.061609e-01	0.514
CD209 (DC-SIGN) signaling	R-HSA-5621575	3.061609e-01	0.514
Transcriptional regulation by RUNX1	R-HSA-8878171	3.093819e-01	0.510
RUNX3 regulates WNT signaling	R-HSA-8951430	3.102836e-01	0.508
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	3.102836e-01	0.508
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	3.102836e-01	0.508
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	3.129405e-01	0.505
Circadian clock	R-HSA-9909396	3.129869e-01	0.504
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	3.189594e-01	0.496
Long-term potentiation	R-HSA-9620244	3.197260e-01	0.495
Laminin interactions	R-HSA-3000157	3.197260e-01	0.495
HDMs demethylate histones	R-HSA-3214842	3.197260e-01	0.495
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	3.197260e-01	0.495
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	3.212425e-01	0.493
Deubiquitination	R-HSA-5688426	3.268253e-01	0.486
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	3.296669e-01	0.482
Late SARS-CoV-2 Infection Events	R-HSA-9772573	3.296669e-01	0.482
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	3.332258e-01	0.477
TRP channels	R-HSA-3295583	3.332258e-01	0.477
Reverse Transcription of HIV RNA	R-HSA-162589	3.354432e-01	0.474
Minus-strand DNA synthesis	R-HSA-164516	3.354432e-01	0.474
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	3.354432e-01	0.474
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	3.354432e-01	0.474
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	3.354432e-01	0.474
TCF dependent signaling in response to WNT	R-HSA-201681	3.377978e-01	0.471
EPHA-mediated growth cone collapse	R-HSA-3928663	3.466471e-01	0.460
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	3.466471e-01	0.460
Diseases of carbohydrate metabolism	R-HSA-5663084	3.545669e-01	0.450
Lipophagy	R-HSA-9613354	3.596865e-01	0.444
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	3.596865e-01	0.444
Inactivation of CDC42 and RAC1	R-HSA-428543	3.596865e-01	0.444
Calcineurin activates NFAT	R-HSA-2025928	3.596865e-01	0.444
Regulation of signaling by NODAL	R-HSA-1433617	3.596865e-01	0.444
MASTL Facilitates Mitotic Progression	R-HSA-2465910	3.596865e-01	0.444
GP1b-IX-V activation signalling	R-HSA-430116	3.596865e-01	0.444
Signaling by FGFR2 in disease	R-HSA-5655253	3.649710e-01	0.438
CLEC7A (Dectin-1) signaling	R-HSA-5607764	3.659769e-01	0.437
Hemostasis	R-HSA-109582	3.719237e-01	0.430
Signaling by ERBB2 KD Mutants	R-HSA-9664565	3.732066e-01	0.428
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	3.732066e-01	0.428
Toll-like Receptor Cascades	R-HSA-168898	3.791698e-01	0.421
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	3.830468e-01	0.417
2-LTR circle formation	R-HSA-164843	3.830468e-01	0.417
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	3.830468e-01	0.417
MET activates RAP1 and RAC1	R-HSA-8875555	3.830468e-01	0.417
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	3.830468e-01	0.417
Signal attenuation	R-HSA-74749	3.830468e-01	0.417
Formation of RNA Pol II elongation complex	R-HSA-112382	3.849398e-01	0.415
Uptake and actions of bacterial toxins	R-HSA-5339562	3.849398e-01	0.415
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	3.863231e-01	0.413
Activation of the pre-replicative complex	R-HSA-68962	3.863231e-01	0.413
Signaling by ERBB2 in Cancer	R-HSA-1227990	3.863231e-01	0.413
Chromosome Maintenance	R-HSA-73886	3.863909e-01	0.413
RNA Polymerase II Transcription Elongation	R-HSA-75955	3.948709e-01	0.404
Meiotic synapsis	R-HSA-1221632	3.948709e-01	0.404
Molecules associated with elastic fibres	R-HSA-2129379	3.993181e-01	0.399
Signal Transduction	R-HSA-162582	4.023153e-01	0.395
Sensory processing of sound	R-HSA-9659379	4.044744e-01	0.393
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	4.055563e-01	0.392
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	4.055563e-01	0.392
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	4.055563e-01	0.392
Conjugation of benzoate with glycine	R-HSA-177135	4.055563e-01	0.392
vRNP Assembly	R-HSA-192905	4.055563e-01	0.392
Signaling by APC mutants	R-HSA-4839744	4.055563e-01	0.392
vRNA Synthesis	R-HSA-192814	4.055563e-01	0.392
Bicarbonate transporters	R-HSA-425381	4.055563e-01	0.392
Prostanoid ligand receptors	R-HSA-391908	4.055563e-01	0.392
Dissolution of Fibrin Clot	R-HSA-75205	4.055563e-01	0.392
Disorders of transmembrane transporters	R-HSA-5619115	4.062722e-01	0.391
C-type lectin receptors (CLRs)	R-HSA-5621481	4.096519e-01	0.388
Diseases of mitotic cell cycle	R-HSA-9675126	4.121830e-01	0.385
Signaling by WNT in cancer	R-HSA-4791275	4.121830e-01	0.385
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	4.121830e-01	0.385
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	4.127367e-01	0.384
Ub-specific processing proteases	R-HSA-5689880	4.207784e-01	0.376
Detoxification of Reactive Oxygen Species	R-HSA-3299685	4.243887e-01	0.372
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	4.249099e-01	0.372
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	4.249099e-01	0.372
Gastrulation	R-HSA-9758941	4.262265e-01	0.370
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	4.272458e-01	0.369
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	4.272458e-01	0.369
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	4.272458e-01	0.369
Plasmalogen biosynthesis	R-HSA-75896	4.272458e-01	0.369
ERKs are inactivated	R-HSA-202670	4.272458e-01	0.369
Signaling by AMER1 mutants	R-HSA-4839748	4.272458e-01	0.369
Signaling by AXIN mutants	R-HSA-4839735	4.272458e-01	0.369
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	4.272458e-01	0.369
Activation of RAC1	R-HSA-428540	4.272458e-01	0.369
Sensing of DNA Double Strand Breaks	R-HSA-5693548	4.272458e-01	0.369
Disease	R-HSA-1643685	4.311979e-01	0.365
RSV-host interactions	R-HSA-9833110	4.312776e-01	0.365
Potential therapeutics for SARS	R-HSA-9679191	4.321999e-01	0.364
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	4.341200e-01	0.362
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	4.374918e-01	0.359
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	4.437899e-01	0.353
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	4.437899e-01	0.353
Early SARS-CoV-2 Infection Events	R-HSA-9772572	4.437899e-01	0.353
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	4.441207e-01	0.352
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	4.481452e-01	0.349
Scavenging by Class F Receptors	R-HSA-3000484	4.481452e-01	0.349
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	4.481452e-01	0.349
Repression of WNT target genes	R-HSA-4641265	4.481452e-01	0.349
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	4.481452e-01	0.349
Conjugation of salicylate with glycine	R-HSA-177128	4.481452e-01	0.349
Trafficking and processing of endosomal TLR	R-HSA-1679131	4.481452e-01	0.349
Polymerase switching	R-HSA-69091	4.481452e-01	0.349
Leading Strand Synthesis	R-HSA-69109	4.481452e-01	0.349
Maple Syrup Urine Disease	R-HSA-9865114	4.481452e-01	0.349
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	4.481452e-01	0.349
OAS antiviral response	R-HSA-8983711	4.481452e-01	0.349
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	4.499224e-01	0.347
RAF activation	R-HSA-5673000	4.499224e-01	0.347
Signaling by Nuclear Receptors	R-HSA-9006931	4.534725e-01	0.343
Death Receptor Signaling	R-HSA-73887	4.559987e-01	0.341
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	4.621960e-01	0.335
Signalling to ERKs	R-HSA-187687	4.621960e-01	0.335
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	4.682833e-01	0.329
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	4.682833e-01	0.329
Frs2-mediated activation	R-HSA-170968	4.682833e-01	0.329
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	4.682833e-01	0.329
CD28 dependent Vav1 pathway	R-HSA-389359	4.682833e-01	0.329
Maturation of nucleoprotein	R-HSA-9683610	4.682833e-01	0.329
Interleukin-6 signaling	R-HSA-1059683	4.682833e-01	0.329
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	4.697141e-01	0.328
PLC beta mediated events	R-HSA-112043	4.723913e-01	0.326
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	4.743074e-01	0.324
RET signaling	R-HSA-8853659	4.743074e-01	0.324
RNA Polymerase III Transcription	R-HSA-74158	4.743074e-01	0.324
FGFR2 mutant receptor activation	R-HSA-1839126	4.743074e-01	0.324
Asparagine N-linked glycosylation	R-HSA-446203	4.793317e-01	0.319
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.795881e-01	0.319
Removal of the Flap Intermediate	R-HSA-69166	4.876876e-01	0.312
Retrograde neurotrophin signalling	R-HSA-177504	4.876876e-01	0.312
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	4.876876e-01	0.312
Signaling by FGFR4 in disease	R-HSA-5655291	4.876876e-01	0.312
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	4.876876e-01	0.312
Malate-aspartate shuttle	R-HSA-9856872	4.876876e-01	0.312
Respiratory syncytial virus genome transcription	R-HSA-9828642	4.876876e-01	0.312
Regulation of TP53 Activity	R-HSA-5633007	4.912812e-01	0.309
MET promotes cell motility	R-HSA-8875878	4.980265e-01	0.303
Elastic fibre formation	R-HSA-1566948	4.980265e-01	0.303
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	4.980265e-01	0.303
Base Excision Repair	R-HSA-73884	5.013594e-01	0.300
Erythropoietin activates RAS	R-HSA-9027284	5.063850e-01	0.296
RNA Polymerase III Chain Elongation	R-HSA-73780	5.063850e-01	0.296
Processive synthesis on the lagging strand	R-HSA-69183	5.063850e-01	0.296
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	5.063850e-01	0.296
p38MAPK events	R-HSA-171007	5.063850e-01	0.296
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	5.063850e-01	0.296
Other semaphorin interactions	R-HSA-416700	5.063850e-01	0.296
Pentose phosphate pathway	R-HSA-71336	5.096268e-01	0.293
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	5.210500e-01	0.283
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	5.210500e-01	0.283
Inhibition of DNA recombination at telomere	R-HSA-9670095	5.210500e-01	0.283
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	5.210500e-01	0.283
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	5.244011e-01	0.280
Phosphorylation of the APC/C	R-HSA-176412	5.244011e-01	0.280
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	5.244011e-01	0.280
Defective GALNT3 causes HFTC	R-HSA-5083625	5.244011e-01	0.280
Defective GALNT12 causes CRCS1	R-HSA-5083636	5.244011e-01	0.280
WNT5A-dependent internalization of FZD4	R-HSA-5099900	5.244011e-01	0.280
Prolonged ERK activation events	R-HSA-169893	5.244011e-01	0.280
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	5.244011e-01	0.280
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	5.244011e-01	0.280
Attachment and Entry	R-HSA-9678110	5.244011e-01	0.280
FCGR3A-mediated phagocytosis	R-HSA-9664422	5.273702e-01	0.278
Parasite infection	R-HSA-9664407	5.273702e-01	0.278
Leishmania phagocytosis	R-HSA-9664417	5.273702e-01	0.278
G-protein mediated events	R-HSA-112040	5.274486e-01	0.278
Metabolism of proteins	R-HSA-392499	5.284326e-01	0.277
PKMTs methylate histone lysines	R-HSA-3214841	5.322937e-01	0.274
Transcriptional Regulation by VENTX	R-HSA-8853884	5.322937e-01	0.274
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	5.335081e-01	0.273
Transcription of the HIV genome	R-HSA-167172	5.363132e-01	0.271
Transcriptional Regulation by TP53	R-HSA-3700989	5.373478e-01	0.270
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	5.417607e-01	0.266
Processing of Intronless Pre-mRNAs	R-HSA-77595	5.417607e-01	0.266
Fibronectin matrix formation	R-HSA-1566977	5.417607e-01	0.266
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	5.417607e-01	0.266
Biosynthesis of maresin-like SPMs	R-HSA-9027307	5.417607e-01	0.266
Transcriptional regulation of testis differentiation	R-HSA-9690406	5.417607e-01	0.266
Vitamin B6 activation to pyridoxal phosphate	R-HSA-964975	5.417607e-01	0.266
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	5.417607e-01	0.266
tRNA modification in the mitochondrion	R-HSA-6787450	5.417607e-01	0.266
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	5.417607e-01	0.266
Extracellular matrix organization	R-HSA-1474244	5.419587e-01	0.266
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	5.433558e-01	0.265
HIV Transcription Initiation	R-HSA-167161	5.433558e-01	0.265
RNA Polymerase II Transcription Initiation	R-HSA-75953	5.433558e-01	0.265
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	5.433558e-01	0.265
COPII-mediated vesicle transport	R-HSA-204005	5.537547e-01	0.257
tRNA processing	R-HSA-72306	5.539647e-01	0.257
RNA Polymerase I Transcription Initiation	R-HSA-73762	5.542345e-01	0.256
FCERI mediated NF-kB activation	R-HSA-2871837	5.577137e-01	0.254
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	5.584876e-01	0.253
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	5.584876e-01	0.253
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	5.584876e-01	0.253
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	5.584876e-01	0.253
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	5.584876e-01	0.253
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	5.584876e-01	0.253
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	5.584876e-01	0.253
Uptake and function of anthrax toxins	R-HSA-5210891	5.584876e-01	0.253
Adaptive Immune System	R-HSA-1280218	5.642048e-01	0.249
RNA Polymerase II Promoter Escape	R-HSA-73776	5.649284e-01	0.248
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	5.746050e-01	0.241
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	5.746050e-01	0.241
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	5.746050e-01	0.241
Polo-like kinase mediated events	R-HSA-156711	5.746050e-01	0.241
Mismatch Repair	R-HSA-5358508	5.746050e-01	0.241
Netrin-1 signaling	R-HSA-373752	5.754367e-01	0.240
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	5.817394e-01	0.235
HATs acetylate histones	R-HSA-3214847	5.836592e-01	0.234
FOXO-mediated transcription	R-HSA-9614085	5.836592e-01	0.234
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	5.857585e-01	0.232
Somitogenesis	R-HSA-9824272	5.857585e-01	0.232
RNA Polymerase II Pre-transcription Events	R-HSA-674695	5.874370e-01	0.231
Signaling by FGFR in disease	R-HSA-1226099	5.874370e-01	0.231
PI-3K cascade:FGFR3	R-HSA-5654710	5.901350e-01	0.229
Germ layer formation at gastrulation	R-HSA-9754189	5.901350e-01	0.229
Specification of the neural plate border	R-HSA-9834899	5.901350e-01	0.229
Amino Acid conjugation	R-HSA-156587	5.901350e-01	0.229
Conjugation of carboxylic acids	R-HSA-159424	5.901350e-01	0.229
The NLRP3 inflammasome	R-HSA-844456	5.901350e-01	0.229
O2/CO2 exchange in erythrocytes	R-HSA-1480926	5.901350e-01	0.229
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	5.901350e-01	0.229
Maturation of nucleoprotein	R-HSA-9694631	5.901350e-01	0.229
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	5.901350e-01	0.229
Condensation of Prophase Chromosomes	R-HSA-2299718	5.958936e-01	0.225
RNA Polymerase I Promoter Clearance	R-HSA-73854	6.036551e-01	0.219
Interleukin-1 family signaling	R-HSA-446652	6.042725e-01	0.219
PI-3K cascade:FGFR4	R-HSA-5654720	6.050989e-01	0.218
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	6.050989e-01	0.218
Wax and plasmalogen biosynthesis	R-HSA-8848584	6.050989e-01	0.218
Signaling by NODAL	R-HSA-1181150	6.050989e-01	0.218
Nephrin family interactions	R-HSA-373753	6.050989e-01	0.218
Eicosanoid ligand-binding receptors	R-HSA-391903	6.050989e-01	0.218
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	6.116046e-01	0.214
Signaling by NTRK1 (TRKA)	R-HSA-187037	6.131499e-01	0.212
Opioid Signalling	R-HSA-111885	6.183687e-01	0.209
Integrin cell surface interactions	R-HSA-216083	6.194466e-01	0.208
RNA Polymerase I Transcription	R-HSA-73864	6.194466e-01	0.208
Lagging Strand Synthesis	R-HSA-69186	6.195173e-01	0.208
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	6.195173e-01	0.208
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	6.195173e-01	0.208
Zygotic genome activation (ZGA)	R-HSA-9819196	6.195173e-01	0.208
Signalling to RAS	R-HSA-167044	6.195173e-01	0.208
Transmission across Chemical Synapses	R-HSA-112315	6.216608e-01	0.206
Activation of HOX genes during differentiation	R-HSA-5619507	6.250895e-01	0.204
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	6.250895e-01	0.204
Reproduction	R-HSA-1474165	6.312059e-01	0.200
FRS-mediated FGFR3 signaling	R-HSA-5654706	6.334102e-01	0.198
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	6.334102e-01	0.198
Serine metabolism	R-HSA-977347	6.334102e-01	0.198
Attachment and Entry	R-HSA-9694614	6.334102e-01	0.198
Signaling by PDGFR in disease	R-HSA-9671555	6.334102e-01	0.198
Signaling by WNT	R-HSA-195721	6.344116e-01	0.198
Branched-chain amino acid catabolism	R-HSA-70895	6.437710e-01	0.191
PI-3K cascade:FGFR1	R-HSA-5654689	6.467966e-01	0.189
FRS-mediated FGFR4 signaling	R-HSA-5654712	6.467966e-01	0.189
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	6.467966e-01	0.189
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	6.467966e-01	0.189
LDL clearance	R-HSA-8964038	6.467966e-01	0.189
mRNA 3'-end processing	R-HSA-72187	6.527910e-01	0.185
Ion channel transport	R-HSA-983712	6.532667e-01	0.185
Termination of O-glycan biosynthesis	R-HSA-977068	6.596950e-01	0.181
Biosynthesis of maresins	R-HSA-9018682	6.596950e-01	0.181
Formation of the ureteric bud	R-HSA-9830674	6.596950e-01	0.181
Growth hormone receptor signaling	R-HSA-982772	6.596950e-01	0.181
Bacterial Infection Pathways	R-HSA-9824439	6.641643e-01	0.178
Meiosis	R-HSA-1500620	6.712874e-01	0.173
CYP2E1 reactions	R-HSA-211999	6.721231e-01	0.173
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	6.721231e-01	0.173
Complex III assembly	R-HSA-9865881	6.721231e-01	0.173
Interleukin-6 family signaling	R-HSA-6783589	6.721231e-01	0.173
Inositol phosphate metabolism	R-HSA-1483249	6.760948e-01	0.170
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	6.782541e-01	0.169
PI-3K cascade:FGFR2	R-HSA-5654695	6.840981e-01	0.165
FRS-mediated FGFR1 signaling	R-HSA-5654693	6.840981e-01	0.165
TGFBR3 expression	R-HSA-9839394	6.840981e-01	0.165
Polymerase switching on the C-strand of the telomere	R-HSA-174411	6.840981e-01	0.165
MicroRNA (miRNA) biogenesis	R-HSA-203927	6.840981e-01	0.165
Formation of the nephric duct	R-HSA-9830364	6.840981e-01	0.165
Aerobic respiration and respiratory electron transport	R-HSA-1428517	6.893055e-01	0.162
Dectin-2 family	R-HSA-5621480	6.951766e-01	0.158
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	6.956364e-01	0.158
Signaling by FLT3 fusion proteins	R-HSA-9703465	6.956364e-01	0.158
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	6.956364e-01	0.158
MET activates PTK2 signaling	R-HSA-8874081	6.956364e-01	0.158
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	6.956364e-01	0.158
Processive synthesis on the C-strand of the telomere	R-HSA-174414	7.067540e-01	0.151
Packaging Of Telomere Ends	R-HSA-171306	7.067540e-01	0.151
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	7.067540e-01	0.151
Cristae formation	R-HSA-8949613	7.067540e-01	0.151
RNA Polymerase I Promoter Opening	R-HSA-73728	7.067540e-01	0.151
Signaling by FGFR3 in disease	R-HSA-5655332	7.067540e-01	0.151
Signaling by NTRK2 (TRKB)	R-HSA-9006115	7.067540e-01	0.151
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	7.108944e-01	0.148
Rab regulation of trafficking	R-HSA-9007101	7.166086e-01	0.145
FRS-mediated FGFR2 signaling	R-HSA-5654700	7.174661e-01	0.144
Insulin receptor recycling	R-HSA-77387	7.174661e-01	0.144
Phase 0 - rapid depolarisation	R-HSA-5576892	7.174661e-01	0.144
Inflammasomes	R-HSA-622312	7.174661e-01	0.144
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	7.174661e-01	0.144
RNA Polymerase II Transcription Termination	R-HSA-73856	7.259284e-01	0.139
Formation of paraxial mesoderm	R-HSA-9793380	7.259284e-01	0.139
Signaling by Erythropoietin	R-HSA-9006335	7.277875e-01	0.138
DNA methylation	R-HSA-5334118	7.277875e-01	0.138
Downstream signaling of activated FGFR3	R-HSA-5654708	7.277875e-01	0.138
DARPP-32 events	R-HSA-180024	7.277875e-01	0.138
Mitochondrial protein import	R-HSA-1268020	7.331943e-01	0.135
Transcriptional regulation of granulopoiesis	R-HSA-9616222	7.331943e-01	0.135
FCGR activation	R-HSA-2029481	7.360519e-01	0.133
Downstream signaling of activated FGFR4	R-HSA-5654716	7.377325e-01	0.132
RNA Polymerase III Transcription Initiation	R-HSA-76046	7.377325e-01	0.132
GABA synthesis, release, reuptake and degradation	R-HSA-888590	7.377325e-01	0.132
SHC1 events in ERBB2 signaling	R-HSA-1250196	7.377325e-01	0.132
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	7.377325e-01	0.132
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	7.377325e-01	0.132
Signaling by NTRKs	R-HSA-166520	7.377859e-01	0.132
Mitochondrial protein degradation	R-HSA-9837999	7.419380e-01	0.130
Insulin receptor signalling cascade	R-HSA-74751	7.472353e-01	0.127
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	7.473148e-01	0.126
Trafficking of AMPA receptors	R-HSA-399719	7.473148e-01	0.126
Cargo concentration in the ER	R-HSA-5694530	7.473148e-01	0.126
Formation of the cornified envelope	R-HSA-6809371	7.532714e-01	0.123
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	7.565475e-01	0.121
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	7.565475e-01	0.121
Telomere Maintenance	R-HSA-157579	7.644430e-01	0.117
Integrin signaling	R-HSA-354192	7.654434e-01	0.116
Nuclear RNA decay	R-HSA-9930044	7.654434e-01	0.116
Assembly of the ORC complex at the origin of replication	R-HSA-68616	7.654434e-01	0.116
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	7.654434e-01	0.116
Cardiogenesis	R-HSA-9733709	7.654434e-01	0.116
Regulation of MECP2 expression and activity	R-HSA-9022692	7.654434e-01	0.116
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	7.654434e-01	0.116
Kidney development	R-HSA-9830369	7.671048e-01	0.115
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	7.734199e-01	0.112
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	7.740147e-01	0.111
Effects of PIP2 hydrolysis	R-HSA-114508	7.740147e-01	0.111
Heme degradation	R-HSA-189483	7.740147e-01	0.111
HCMV Late Events	R-HSA-9610379	7.777190e-01	0.109
eNOS activation	R-HSA-203615	7.822734e-01	0.107
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	7.822734e-01	0.107
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	7.890943e-01	0.103
Downstream signaling of activated FGFR2	R-HSA-5654696	7.902307e-01	0.102
Downstream signaling of activated FGFR1	R-HSA-5654687	7.902307e-01	0.102
PERK regulates gene expression	R-HSA-381042	7.902307e-01	0.102
Neddylation	R-HSA-8951664	7.906625e-01	0.102
NoRC negatively regulates rRNA expression	R-HSA-427413	7.914755e-01	0.102
ECM proteoglycans	R-HSA-3000178	7.914755e-01	0.102
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	7.972059e-01	0.098
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	7.972059e-01	0.098
PRC2 methylates histones and DNA	R-HSA-212300	7.978977e-01	0.098
GPVI-mediated activation cascade	R-HSA-114604	7.978977e-01	0.098
Aspirin ADME	R-HSA-9749641	8.027966e-01	0.095
Voltage gated Potassium channels	R-HSA-1296072	8.052849e-01	0.094
SIRT1 negatively regulates rRNA expression	R-HSA-427359	8.052849e-01	0.094
Cleavage of the damaged purine	R-HSA-110331	8.052849e-01	0.094
tRNA processing in the mitochondrion	R-HSA-6785470	8.124025e-01	0.090
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	8.124025e-01	0.090
Depurination	R-HSA-73927	8.124025e-01	0.090
SLC-mediated transport of inorganic anions	R-HSA-9958790	8.124025e-01	0.090
SLC transporter disorders	R-HSA-5619102	8.164256e-01	0.088
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	8.192604e-01	0.087
Transcriptional Regulation by E2F6	R-HSA-8953750	8.192604e-01	0.087
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	8.192604e-01	0.087
Signaling by ALK	R-HSA-201556	8.192604e-01	0.087
rRNA processing in the mitochondrion	R-HSA-8868766	8.258679e-01	0.083
Nuclear signaling by ERBB4	R-HSA-1251985	8.258679e-01	0.083
Mitochondrial tRNA aminoacylation	R-HSA-379726	8.258679e-01	0.083
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	8.322343e-01	0.080
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	8.322343e-01	0.080
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	8.382316e-01	0.077
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	8.383683e-01	0.077
Signaling by FGFR1 in disease	R-HSA-5655302	8.383683e-01	0.077
Scavenging by Class A Receptors	R-HSA-3000480	8.383683e-01	0.077
FCERI mediated MAPK activation	R-HSA-2871796	8.389432e-01	0.076
Cell surface interactions at the vascular wall	R-HSA-202733	8.405199e-01	0.075
Cytosolic tRNA aminoacylation	R-HSA-379716	8.442784e-01	0.074
Incretin synthesis, secretion, and inactivation	R-HSA-400508	8.442784e-01	0.074
Cleavage of the damaged pyrimidine	R-HSA-110329	8.442784e-01	0.074
Depyrimidination	R-HSA-73928	8.442784e-01	0.074
Defective pyroptosis	R-HSA-9710421	8.499727e-01	0.071
TBC/RABGAPs	R-HSA-8854214	8.499727e-01	0.071
Proteasome assembly	R-HSA-9907900	8.554592e-01	0.068
Platelet Aggregation (Plug Formation)	R-HSA-76009	8.607453e-01	0.065
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	8.658384e-01	0.063
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	8.658384e-01	0.063
Signaling by TGFBR3	R-HSA-9839373	8.658384e-01	0.063
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	8.678063e-01	0.062
PI3K/AKT Signaling in Cancer	R-HSA-2219528	8.679068e-01	0.062
Neuronal System	R-HSA-112316	8.691996e-01	0.061
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	8.707456e-01	0.060
GPER1 signaling	R-HSA-9634597	8.754735e-01	0.058
Chemokine receptors bind chemokines	R-HSA-380108	8.800288e-01	0.056
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	8.814875e-01	0.055
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	8.835878e-01	0.054
PI3K Cascade	R-HSA-109704	8.844177e-01	0.053
Azathioprine ADME	R-HSA-9748787	8.844177e-01	0.053
Pre-NOTCH Transcription and Translation	R-HSA-1912408	8.858008e-01	0.053
Meiotic recombination	R-HSA-912446	8.886463e-01	0.051
Signaling by Insulin receptor	R-HSA-74752	8.923422e-01	0.049
RNA Polymerase I Promoter Escape	R-HSA-73772	8.927205e-01	0.049
Neurexins and neuroligins	R-HSA-6794361	8.927205e-01	0.049
Interferon gamma signaling	R-HSA-877300	8.943818e-01	0.048
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	8.949160e-01	0.048
Nucleotide biosynthesis	R-HSA-8956320	8.966458e-01	0.047
Collagen formation	R-HSA-1474290	8.985343e-01	0.046
Base-Excision Repair, AP Site Formation	R-HSA-73929	9.004278e-01	0.046
G alpha (z) signalling events	R-HSA-418597	9.040715e-01	0.044
Paracetamol ADME	R-HSA-9753281	9.040715e-01	0.044
Negative regulation of the PI3K/AKT network	R-HSA-199418	9.052450e-01	0.043
NRAGE signals death through JNK	R-HSA-193648	9.075822e-01	0.042
Ion homeostasis	R-HSA-5578775	9.075822e-01	0.042
Adipogenesis	R-HSA-9843745	9.100577e-01	0.041
IRS-mediated signalling	R-HSA-112399	9.109646e-01	0.040
Post-translational protein phosphorylation	R-HSA-8957275	9.125924e-01	0.040
Extension of Telomeres	R-HSA-180786	9.173631e-01	0.037
tRNA Aminoacylation	R-HSA-379724	9.203880e-01	0.036
Metabolism of polyamines	R-HSA-351202	9.203880e-01	0.036
IRS-related events triggered by IGF1R	R-HSA-2428928	9.233024e-01	0.035
Collagen degradation	R-HSA-1442490	9.233024e-01	0.035
NCAM signaling for neurite out-growth	R-HSA-375165	9.261103e-01	0.033
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	9.288156e-01	0.032
Complex I biogenesis	R-HSA-6799198	9.288156e-01	0.032
Parasitic Infection Pathways	R-HSA-9824443	9.302434e-01	0.031
Leishmania infection	R-HSA-9658195	9.302434e-01	0.031
Post-translational protein modification	R-HSA-597592	9.303986e-01	0.031
Xenobiotics	R-HSA-211981	9.314220e-01	0.031
CD22 mediated BCR regulation	R-HSA-5690714	9.314220e-01	0.031
Ion transport by P-type ATPases	R-HSA-936837	9.314220e-01	0.031
IGF1R signaling cascade	R-HSA-2428924	9.314220e-01	0.031
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.326843e-01	0.030
Platelet homeostasis	R-HSA-418346	9.334043e-01	0.030
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	9.339331e-01	0.030
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.363524e-01	0.029
Nicotinate metabolism	R-HSA-196807	9.386832e-01	0.027
O-linked glycosylation of mucins	R-HSA-913709	9.409288e-01	0.026
Pre-NOTCH Expression and Processing	R-HSA-1912422	9.462520e-01	0.024
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.471849e-01	0.024
Metabolism of cofactors	R-HSA-8978934	9.471849e-01	0.024
Metabolism of porphyrins	R-HSA-189445	9.471849e-01	0.024
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.494659e-01	0.023
Ca2+ pathway	R-HSA-4086398	9.509837e-01	0.022
TP53 Regulates Metabolic Genes	R-HSA-5628897	9.510034e-01	0.022
Role of phospholipids in phagocytosis	R-HSA-2029485	9.524961e-01	0.021
Peptide hormone metabolism	R-HSA-2980736	9.553524e-01	0.020
Nuclear Receptor transcription pathway	R-HSA-383280	9.593294e-01	0.018
G alpha (12/13) signalling events	R-HSA-416482	9.593294e-01	0.018
SLC-mediated transport of organic anions	R-HSA-9955298	9.593294e-01	0.018
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	9.608199e-01	0.017
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.608199e-01	0.017
Sphingolipid metabolism	R-HSA-428157	9.631401e-01	0.016
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.636393e-01	0.016
Cytoprotection by HMOX1	R-HSA-9707564	9.662561e-01	0.015
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	9.662927e-01	0.015
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	9.662927e-01	0.015
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	9.662927e-01	0.015
Keratinization	R-HSA-6805567	9.684200e-01	0.014
Protein-protein interactions at synapses	R-HSA-6794362	9.686849e-01	0.014
G alpha (s) signalling events	R-HSA-418555	9.722251e-01	0.012
Leishmania parasite growth and survival	R-HSA-9664433	9.737598e-01	0.012
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.737598e-01	0.012
Class B/2 (Secretin family receptors)	R-HSA-373080	9.749731e-01	0.011
Neurotransmitter release cycle	R-HSA-112310	9.749731e-01	0.011
Transcriptional Regulation by MECP2	R-HSA-8986944	9.758911e-01	0.011
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.784480e-01	0.009
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	9.792387e-01	0.009
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.814411e-01	0.008
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	9.814411e-01	0.008
Potassium Channels	R-HSA-1296071	9.814411e-01	0.008
Extra-nuclear estrogen signaling	R-HSA-9009391	9.846057e-01	0.007
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.862002e-01	0.006
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.918507e-01	0.004
Mitochondrial biogenesis	R-HSA-1592230	9.924386e-01	0.003
Drug ADME	R-HSA-9748784	9.931906e-01	0.003
Respiratory electron transport	R-HSA-611105	9.946567e-01	0.002
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.951184e-01	0.002
Cardiac conduction	R-HSA-5576891	9.958475e-01	0.002
Degradation of the extracellular matrix	R-HSA-1474228	9.960003e-01	0.002
Metabolism of nucleotides	R-HSA-15869	9.960572e-01	0.002
Integration of energy metabolism	R-HSA-163685	9.966839e-01	0.001
O-linked glycosylation	R-HSA-5173105	9.968059e-01	0.001
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	9.975434e-01	0.001
PPARA activates gene expression	R-HSA-1989781	9.984341e-01	0.001
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.985473e-01	0.001
Cytochrome P450 - arranged by substrate type	R-HSA-211897	9.990022e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.990991e-01	0.000
Diseases of metabolism	R-HSA-5668914	9.992213e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.994928e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.995295e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.996162e-01	0.000
Phase I - Functionalization of compounds	R-HSA-211945	9.998271e-01	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	9.999341e-01	0.000
Phase II - Conjugation of compounds	R-HSA-156580	9.999385e-01	0.000
G alpha (q) signalling events	R-HSA-416476	9.999761e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999931e-01	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	9.999972e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999975e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999975e-01	0.000
Signaling by GPCR	R-HSA-372790	9.999977e-01	0.000
Transport of small molecules	R-HSA-382551	9.999992e-01	0.000
Biological oxidations	R-HSA-211859	9.999997e-01	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Metabolism	R-HSA-1430728	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000