STK33

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

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substrate_uniprot	site	source	substrate_genes	site_seq
A0A2R8Y4L2	S95	Sugiyama	HNRNPA1L3 HNRNPA1P48	RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A6NKT7	S1006	Sugiyama	RGPD3 RGP3	FGKKDLNFKGFSGAGEKLFSsQYGKMANKANtsGDFEKDDD
O00165	S153	Sugiyama	HAX1 HS1BP1	PDSHQPRIFGGVLESDARSEsPQPAPDWGsQRPFHRFDDVW
O14979	T165	Sugiyama	HNRNPDL HNRPDL JKTBP	QDDGKMFIGGLSWDTsKKDLtEyLSRFGEVVDCtIKTDPVT
O43390	T134	Sugiyama	HNRNPR HNRPR	KVQESTKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDS
O60506	T131	Sugiyama	SYNCRIP HNRPQ NSAP1	KVADSSKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDS
O60716	S252	Sugiyama	CTNND1 KIAA0384	sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
O95757	S599	Sugiyama	HSPA4L APG1 HSPH3 OSP94	sIDLPIQssLCRQLGQDLLNsyIENEGKMIMQDKLEKERND
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075	T37	Sugiyama	ALDOA ALDA	sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04406	T237	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05386	S101	Sugiyama	RPLP1 RRP1	APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386	S104	Sugiyama	RPLP1 RRP1	tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387	S102	Sugiyama	RPLP2 D11S2243E RPP2	PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387	S105	Sugiyama	RPLP2 D11S2243E RPP2	GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P06733	S27	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P06733	Y44	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P06748	S70	Sugiyama	NPM1 NPM	GAGAKDELHIVEAEAMNyEGsPIKVtLAtLKMsVQPtVsLG
P07900	S399	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNLVKK
P08195	T599	Sugiyama	SLC3A2 MDU1	QASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEPH
P08238	S391	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNIVKK
P09651	S95	Sugiyama	HNRNPA1 HNRPA1	RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P10809	T428	Sugiyama	HSPD1 HSP60	GtsDVEVNEKKDRVtDALNAtRAAVEEGIVLGGGCALLRCI
P11142	T66	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P13639	S593	Sugiyama	EEF2 EF2	SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P14625	S64	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	tDDEVVQREEEAIQLDGLNAsQIRELREKSEKFAFQAEVNR
P17812	S575	Sugiyama	CTPS1 CTPS	LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P18615	S135	Sugiyama	NELFE RD RDBP	sADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEG
P18621	S5	Sugiyama	RPL17	________________MVRysLDPENPtKsCKSRGSNLRVH
P20618	S157	Sugiyama	PSMB1 PSC5	IIGGLDEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLL
P23246	S283	Sugiyama	SFPQ PSF	GPGGRsEEKIsDsEGFKANLsLLRRPGEKTyTQRCRLFVGN
P23588	S122	Sugiyama	EIF4B	NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P26373	S181	Sugiyama	RPL13 BBC1 OK/SW-cl.46	YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P27708	S1859	Sugiyama	CAD	RGIPGLPDGRFHLPPRIHRAsDPGLPAEEPKEKSSRKVAEP
P29692	S162	Sugiyama	EEF1D EF1D	AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P32754	T382	SIGNOR	HPD PPD	GNFNSLFKAFEEEQNLRGNLtNMETNGVVPGM_________
P38646	T116	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646	T120	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P38646	T87	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKR
P38646	Y118	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	ERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIK
P39019	Y54	Sugiyama	RPS19	VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39023	S265	Sugiyama	RPL3 OK/SW-cl.32	HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P43487	S60	Sugiyama	RANBP1	TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P49792	S1981	Sugiyama	RANBP2 NUP358	FGKKDPNFKGFSGAGEKLFSsQYGKMANKANtsGDFEKDDD
P51116	S601	Sugiyama	FXR2 FMR1L2	RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P53396	S457	Sugiyama	ACLY	FLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMPQD
P53396	S459	Sugiyama	ACLY	LNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMPQDsV
P60174	T90	Sugiyama	TPI1 TPI	VTNGAFtGEIsPGMIKDCGAtWVVLGHsERRHVFGEsDELI
P61254	T8	Sugiyama	RPL26	_____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P61978	S401	Sugiyama	HNRNPK HNRPK	GDLGGPIIttQVtIPKDLAGsIIGKGGQRIKQIRHEsGAsI
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62263	T133	Sugiyama	RPS14 PRO2640	QsALRALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL__
P63220	S68	Sugiyama	RPS21	GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____
P67809	S102	Sugiyama	YBX1 NSEP1 YB1	EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P85037	S445	Sugiyama	FOXK1 MNF	GLMsPRsGGLQtPECLsREGsPIPHDPEFGsKLASVPEYRY
Q00613	S363	Sugiyama	HSF1 HSTF1	AsVTALtDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNE
Q01082	S1388	Sugiyama	SPTBN1 SPTB2	TTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSDDy
Q01105	S161	Sugiyama	SET	FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q07666	S20	Sugiyama	KHDRBS1 SAM68	_MQRRDDPAARMsRssGRsGsMDPsGAHPsVRQtPsRQPPL
Q13112	S409	Sugiyama	CHAF1B CAF1A CAF1P60 MPHOSPH7 MPP7	VLNMRtPDtAKKTKsQtHRGssPGPRPVEGtPASRtQDPss
Q13112	S410	Sugiyama	CHAF1B CAF1A CAF1P60 MPHOSPH7 MPP7	LNMRtPDtAKKTKsQtHRGssPGPRPVEGtPASRtQDPssP
Q13247	S303	Sugiyama	SRSF6 SFRS6 SRP55	ENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKRAT
Q13283	S232	Sugiyama	G3BP1 G3BP	EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q14152	S584	Sugiyama	EIF3A EIF3S10 KIAA0139	EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14157	T256	Sugiyama	UBAP2L KIAA0144 NICE4	AWRtAtEEWGtEDWNEDLsEtKIFtAsNVssVPLPAENVtI
Q32P51	S95	Sugiyama	HNRNPA1L2 HNRNPA1L	TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q6UN15	S492	Sugiyama	FIP1L1 FIP1 RHE	DRDRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAE
Q7Z4V5	S454	Sugiyama	HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604	VRPEEKQQAKPVKVERTRKRsEGFsMDRKVEKKKEPSVEEK
Q8N684	T203	Sugiyama	CPSF7	GGIPPRAHsRDssDsADGRAtPsENLVPSSARVDKPPSVLP
Q9BQ16	T118	Sugiyama	SPOCK3 TICN3 UNQ409/PRO771	HKVCIAQDSQTAVCISHRRLtHRMKEAGVDHRQWRGPILST
Q9BYT3	S326	Sugiyama	STK33	IWSIGVVMYMLLRGEPPFLAsSEEKLFELIRKGELHFENAV
Q9BYT3	S427	Sugiyama	STK33	SVEENTTEEKNKPSTEEKLKsYQPWGNVPDANytsDEEEEK
Q9BYT3	S441	Sugiyama	STK33	TEEKLKsYQPWGNVPDANytsDEEEEKQSTAYEKQFPATSK
Q9BYT3	S468	Sugiyama	STK33	QSTAYEKQFPATSKDNFDMCsssFtSsKLLPAEIKGEMEKT
Q9BYT3	S469	Sugiyama	STK33	STAYEKQFPATSKDNFDMCsssFtSsKLLPAEIKGEMEKTP
Q9BYT3	S470	Sugiyama	STK33	TAYEKQFPATSKDNFDMCsssFtSsKLLPAEIKGEMEKTPV
Q9BYT3	S474	Sugiyama	STK33	KQFPATSKDNFDMCsssFtSsKLLPAEIKGEMEKTPVtPSQ
Q9BYT3	T382	PSP\|Sugiyama	STK33	MKVDPAHRITAKELLDNQWLtGNKLSSVRPTNVLEMMKEWK
Q9BYT3	T472	Sugiyama	STK33	YEKQFPATSKDNFDMCsssFtSsKLLPAEIKGEMEKTPVtP
Q9BYT3	T491	Sugiyama	STK33	FtSsKLLPAEIKGEMEKTPVtPSQGtATKYPAKSGALSRTK
Q9BYT3	T496	Sugiyama	STK33	LLPAEIKGEMEKTPVtPSQGtATKYPAKSGALSRTKKKL__
Q9NWB6	S77	Sugiyama	ARGLU1	RsRstNTAVSRRERDRERAssPPDRIDIFGRTVSKRSSLDE
Q9UGV2	S327	Sugiyama	NDRG3	KYFLQGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsV
Q9UGV2	T332	Sugiyama	NDRG3	GMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQs
Q9UNX3	T8	Sugiyama	RPL26L1 RPL26P1	_____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Q9UQ35	S1103	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35	S1648	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	APRALPRRSRSGSSSKGRGPsPEGssstEssPEHPPKSRTA
Q9UQ35	S2132	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9UQ35	S2692	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Cell Cycle	R-HSA-1640170	1.110223e-16	15.955
Cell Cycle, Mitotic	R-HSA-69278	7.771561e-16	15.109
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.221245e-15	14.913
Signal Transduction	R-HSA-162582	2.886580e-15	14.540
M Phase	R-HSA-68886	3.256617e-12	11.487
Apoptotic execution phase	R-HSA-75153	4.565470e-11	10.341
Axon guidance	R-HSA-422475	5.455081e-11	10.263
VEGFA-VEGFR2 Pathway	R-HSA-4420097	7.174839e-11	10.144
Cell Cycle Checkpoints	R-HSA-69620	1.774993e-10	9.751
Nervous system development	R-HSA-9675108	7.836009e-10	9.106
Signaling by VEGF	R-HSA-194138	1.301314e-09	8.886
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	2.070015e-09	8.684
Signaling by ALK in cancer	R-HSA-9700206	2.070015e-09	8.684
Apoptotic cleavage of cellular proteins	R-HSA-111465	6.766831e-09	8.170
Cellular Senescence	R-HSA-2559583	1.234749e-08	7.908
Mitotic Prometaphase	R-HSA-68877	1.245496e-07	6.905
Signaling by ERBB2	R-HSA-1227986	1.370842e-07	6.863
Cellular responses to stimuli	R-HSA-8953897	1.703559e-07	6.769
Apoptosis	R-HSA-109581	1.947607e-07	6.710
Post NMDA receptor activation events	R-HSA-438064	2.642774e-07	6.578
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	3.038009e-07	6.517
G2/M Transition	R-HSA-69275	3.448614e-07	6.462
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	4.403812e-07	6.356
Mitotic G2-G2/M phases	R-HSA-453274	4.772766e-07	6.321
Regulation of TP53 Activity	R-HSA-5633007	6.250832e-07	6.204
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	8.795654e-07	6.056
Programmed Cell Death	R-HSA-5357801	9.735939e-07	6.012
Mitotic Prophase	R-HSA-68875	1.025745e-06	5.989
Signaling by RAS mutants	R-HSA-6802949	1.292529e-06	5.889
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.292529e-06	5.889
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.292529e-06	5.889
Signaling downstream of RAS mutants	R-HSA-9649948	1.292529e-06	5.889
Mitotic Anaphase	R-HSA-68882	1.290681e-06	5.889
Cellular response to heat stress	R-HSA-3371556	1.249213e-06	5.903
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.383720e-06	5.859
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.488932e-06	5.827
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	1.752153e-06	5.756
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.718236e-06	5.765
Cellular responses to stress	R-HSA-2262752	1.724452e-06	5.763
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.980726e-06	5.703
Oxidative Stress Induced Senescence	R-HSA-2559580	2.175857e-06	5.662
Oncogenic MAPK signaling	R-HSA-6802957	2.179249e-06	5.662
Signaling by RAF1 mutants	R-HSA-9656223	2.435770e-06	5.613
Cell-Cell communication	R-HSA-1500931	2.780193e-06	5.556
DNA Double Strand Break Response	R-HSA-5693606	2.994748e-06	5.524
RAF activation	R-HSA-5673000	5.189032e-06	5.285
Processing of DNA double-strand break ends	R-HSA-5693607	5.388156e-06	5.269
FLT3 Signaling	R-HSA-9607240	5.532442e-06	5.257
Intracellular signaling by second messengers	R-HSA-9006925	5.722276e-06	5.242
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	6.773056e-06	5.169
G2/M DNA damage checkpoint	R-HSA-69473	6.602006e-06	5.180
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	7.343894e-06	5.134
Signaling by Interleukins	R-HSA-449147	8.339509e-06	5.079
MAPK family signaling cascades	R-HSA-5683057	9.651516e-06	5.015
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	1.067081e-05	4.972
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	1.156309e-05	4.937
DNA Double-Strand Break Repair	R-HSA-5693532	1.472361e-05	4.832
Cell junction organization	R-HSA-446728	1.552246e-05	4.809
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.611664e-05	4.793
Homology Directed Repair	R-HSA-5693538	1.657216e-05	4.781
Cell-extracellular matrix interactions	R-HSA-446353	1.770569e-05	4.752
G2/M Checkpoints	R-HSA-69481	2.058443e-05	4.686
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	2.002000e-05	4.699
Signaling by PTK6	R-HSA-8848021	2.002000e-05	4.699
ISG15 antiviral mechanism	R-HSA-1169408	2.075837e-05	4.683
Negative regulation of MAPK pathway	R-HSA-5675221	2.309501e-05	4.636
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	2.762896e-05	4.559
Regulation of TP53 Expression and Degradation	R-HSA-6806003	2.764465e-05	4.558
Nuclear Envelope Breakdown	R-HSA-2980766	3.079610e-05	4.512
RET signaling	R-HSA-8853659	3.288324e-05	4.483
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	3.245164e-05	4.489
Regulation of TP53 Degradation	R-HSA-6804757	3.288324e-05	4.483
Cytokine Signaling in Immune system	R-HSA-1280215	3.566276e-05	4.448
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	4.026997e-05	4.395
AURKA Activation by TPX2	R-HSA-8854518	4.066674e-05	4.391
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	4.490817e-05	4.348
Transcriptional regulation by RUNX3	R-HSA-8878159	4.908171e-05	4.309
RAF/MAP kinase cascade	R-HSA-5673001	5.051819e-05	4.297
Signaling by ROBO receptors	R-HSA-376176	5.247725e-05	4.280
Nuclear import of Rev protein	R-HSA-180746	5.353344e-05	4.271
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	5.517307e-05	4.258
Transcriptional regulation by small RNAs	R-HSA-5578749	6.278590e-05	4.202
Separation of Sister Chromatids	R-HSA-2467813	7.060889e-05	4.151
AKT phosphorylates targets in the cytosol	R-HSA-198323	7.322069e-05	4.135
Signalling to ERKs	R-HSA-187687	7.300287e-05	4.137
Oncogene Induced Senescence	R-HSA-2559585	7.300287e-05	4.137
Transcriptional Regulation by TP53	R-HSA-3700989	7.337314e-05	4.134
MAP kinase activation	R-HSA-450294	7.999157e-05	4.097
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	8.563543e-05	4.067
Amplification of signal from the kinetochores	R-HSA-141424	8.563543e-05	4.067
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	9.032618e-05	4.044
Downregulation of ERBB4 signaling	R-HSA-1253288	9.032618e-05	4.044
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	8.723121e-05	4.059
Transport of the SLBP independent Mature mRNA	R-HSA-159227	8.723121e-05	4.059
Transcriptional regulation by RUNX1	R-HSA-8878171	9.181611e-05	4.037
PIP3 activates AKT signaling	R-HSA-1257604	9.218804e-05	4.035
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.001568e-04	3.999
MAPK1/MAPK3 signaling	R-HSA-5684996	1.016262e-04	3.993
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.093600e-04	3.961
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.093600e-04	3.961
Signaling by ERBB2 in Cancer	R-HSA-1227990	1.034123e-04	3.985
Downregulation of ERBB2 signaling	R-HSA-8863795	1.034123e-04	3.985
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	1.103265e-04	3.957
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	1.187649e-04	3.925
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.247262e-04	3.904
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.247262e-04	3.904
MyD88 cascade initiated on plasma membrane	R-HSA-975871	1.253576e-04	3.902
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	1.253576e-04	3.902
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	1.253576e-04	3.902
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.359589e-04	3.867
CD209 (DC-SIGN) signaling	R-HSA-5621575	1.407031e-04	3.852
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	1.490862e-04	3.827
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	1.604405e-04	3.795
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	1.604405e-04	3.795
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	1.789942e-04	3.747
Muscle contraction	R-HSA-397014	1.679809e-04	3.775
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.790856e-04	3.747
MAP2K and MAPK activation	R-HSA-5674135	1.845460e-04	3.734
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	1.905553e-04	3.720
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	1.955957e-04	3.709
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	1.982941e-04	3.703
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	2.204447e-04	3.657
Gene expression (Transcription)	R-HSA-74160	2.258082e-04	3.646
Signaling by ERBB2 KD Mutants	R-HSA-9664565	2.323554e-04	3.634
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	2.441632e-04	3.612
MyD88-independent TLR4 cascade	R-HSA-166166	2.441632e-04	3.612
RUNX3 regulates WNT signaling	R-HSA-8951430	2.543660e-04	3.595
SHC1 events in ERBB2 signaling	R-HSA-1250196	3.151686e-04	3.501
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	3.151686e-04	3.501
Signaling by SCF-KIT	R-HSA-1433557	3.057974e-04	3.515
Signaling by Hippo	R-HSA-2028269	2.934209e-04	3.533
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	3.004902e-04	3.522
ESR-mediated signaling	R-HSA-8939211	2.947111e-04	3.531
Interactions of Rev with host cellular proteins	R-HSA-177243	2.961135e-04	3.529
Interactions of Vpr with host cellular proteins	R-HSA-176033	2.961135e-04	3.529
MITF-M-regulated melanocyte development	R-HSA-9730414	3.173468e-04	3.498
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	3.236582e-04	3.490
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	3.236582e-04	3.490
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	3.237478e-04	3.490
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	3.406640e-04	3.468
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	3.797924e-04	3.420
Eukaryotic Translation Elongation	R-HSA-156842	3.515753e-04	3.454
Mitotic Spindle Checkpoint	R-HSA-69618	3.573793e-04	3.447
Signaling by EGFR	R-HSA-177929	3.821901e-04	3.418
Estrogen-dependent gene expression	R-HSA-9018519	3.936546e-04	3.405
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	4.003787e-04	3.398
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	4.223046e-04	3.374
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	4.223046e-04	3.374
Signaling by ERBB2 ECD mutants	R-HSA-9665348	4.334567e-04	3.363
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	4.542345e-04	3.343
Regulation of T cell activation by CD28 family	R-HSA-388841	4.343956e-04	3.362
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	4.542345e-04	3.343
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	4.749363e-04	3.323
Regulation of CDH1 Expression and Function	R-HSA-9764265	4.368496e-04	3.360
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	4.368496e-04	3.360
RNA Polymerase II Transcription	R-HSA-73857	4.913763e-04	3.309
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	4.914554e-04	3.309
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	4.914554e-04	3.309
Nucleosome assembly	R-HSA-774815	4.915469e-04	3.308
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	4.915469e-04	3.308
Interleukin-17 signaling	R-HSA-448424	5.064901e-04	3.295
Regulation of CDH1 Gene Transcription	R-HSA-9764560	5.064901e-04	3.295
PI3K/AKT Signaling in Cancer	R-HSA-2219528	5.361365e-04	3.271
Transcriptional regulation of granulopoiesis	R-HSA-9616222	5.553668e-04	3.255
Centrosome maturation	R-HSA-380287	5.741689e-04	3.241
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	5.905508e-04	3.229
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	6.093099e-04	3.215
G1/S DNA Damage Checkpoints	R-HSA-69615	6.730221e-04	3.172
Transcriptional regulation by RUNX2	R-HSA-8878166	6.144024e-04	3.212
Selective autophagy	R-HSA-9663891	6.580307e-04	3.182
Diseases of programmed cell death	R-HSA-9645723	6.580307e-04	3.182
Interleukin-12 signaling	R-HSA-9020591	6.835892e-04	3.165
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	6.870722e-04	3.163
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	6.935992e-04	3.159
Death Receptor Signaling	R-HSA-73887	7.038275e-04	3.153
IPs transport between nucleus and cytosol	R-HSA-1855170	7.328186e-04	3.135
PRC2 methylates histones and DNA	R-HSA-212300	7.613780e-04	3.118
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	7.751697e-04	3.111
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	7.695276e-04	3.114
Signaling by FGFR4	R-HSA-5654743	7.766754e-04	3.110
Meiotic recombination	R-HSA-912446	7.519550e-04	3.124
MyD88 dependent cascade initiated on endosome	R-HSA-975155	7.981141e-04	3.098
Signaling by EGFR in Cancer	R-HSA-1643713	8.399679e-04	3.076
SARS-CoV-2-host interactions	R-HSA-9705683	8.604645e-04	3.065
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	9.003327e-04	3.046
Striated Muscle Contraction	R-HSA-390522	9.501540e-04	3.022
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	9.501540e-04	3.022
Co-stimulation by CD28	R-HSA-389356	9.509680e-04	3.022
Vpr-mediated nuclear import of PICs	R-HSA-180910	9.727582e-04	3.012
VEGFR2 mediated vascular permeability	R-HSA-5218920	9.782901e-04	3.010
SARS-CoV-1-host interactions	R-HSA-9692914	9.999684e-04	3.000
Signaling by NTRKs	R-HSA-166520	1.073372e-03	2.969
Cell-cell junction organization	R-HSA-421270	1.099376e-03	2.959
Signaling by WNT	R-HSA-195721	1.159557e-03	2.936
Sema3A PAK dependent Axon repulsion	R-HSA-399954	1.182619e-03	2.927
Signaling by FGFR3	R-HSA-5654741	1.203204e-03	2.920
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	1.219855e-03	2.914
Signaling by FGFR1 in disease	R-HSA-5655302	1.225174e-03	2.912
TCF dependent signaling in response to WNT	R-HSA-201681	1.279301e-03	2.893
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.307306e-03	2.884
Influenza Viral RNA Transcription and Replication	R-HSA-168273	1.361959e-03	2.866
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	1.367423e-03	2.864
Apoptosis induced DNA fragmentation	R-HSA-140342	1.370634e-03	2.863
Ephrin signaling	R-HSA-3928664	1.464644e-03	2.834
EPH-Ephrin signaling	R-HSA-2682334	1.409097e-03	2.851
MTOR signalling	R-HSA-165159	1.523088e-03	2.817
Meiosis	R-HSA-1500620	1.430949e-03	2.844
Rab regulation of trafficking	R-HSA-9007101	1.608362e-03	2.794
Generic Transcription Pathway	R-HSA-212436	1.572934e-03	2.803
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	1.528262e-03	2.816
NS1 Mediated Effects on Host Pathways	R-HSA-168276	1.547780e-03	2.810
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	1.677224e-03	2.775
Membrane Trafficking	R-HSA-199991	1.709604e-03	2.767
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	1.716052e-03	2.765
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	1.796365e-03	2.746
Recycling pathway of L1	R-HSA-437239	1.815021e-03	2.741
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.873524e-03	2.727
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	1.929015e-03	2.715
Aggrephagy	R-HSA-9646399	1.929015e-03	2.715
Metabolism of RNA	R-HSA-8953854	1.948751e-03	2.710
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.954862e-03	2.709
Nuclear Receptor transcription pathway	R-HSA-383280	1.954862e-03	2.709
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	1.962922e-03	2.707
NRAGE signals death through JNK	R-HSA-193648	1.988916e-03	2.701
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	2.001040e-03	2.699
Rap1 signalling	R-HSA-392517	2.030623e-03	2.692
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	2.033901e-03	2.692
Negative feedback regulation of MAPK pathway	R-HSA-5674499	2.033901e-03	2.692
mRNA 3'-end processing	R-HSA-72187	2.101647e-03	2.677
Host Interactions of HIV factors	R-HSA-162909	2.105616e-03	2.677
Gene Silencing by RNA	R-HSA-211000	2.128948e-03	2.672
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.148955e-03	2.668
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	2.160989e-03	2.665
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	2.229938e-03	2.652
Notch-HLH transcription pathway	R-HSA-350054	2.250844e-03	2.648
Meiotic synapsis	R-HSA-1221632	2.526596e-03	2.597
mRNA Splicing - Major Pathway	R-HSA-72163	2.285544e-03	2.641
KEAP1-NFE2L2 pathway	R-HSA-9755511	2.538977e-03	2.595
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	2.428093e-03	2.615
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	2.378271e-03	2.624
PKMTs methylate histone lysines	R-HSA-3214841	2.386046e-03	2.622
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	2.444462e-03	2.612
Response of endothelial cells to shear stress	R-HSA-9860931	2.336519e-03	2.631
Developmental Biology	R-HSA-1266738	2.518149e-03	2.599
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	2.305068e-03	2.637
Interleukin-12 family signaling	R-HSA-447115	2.228601e-03	2.652
Interleukin-37 signaling	R-HSA-9008059	2.457102e-03	2.610
Autophagy	R-HSA-9612973	2.549814e-03	2.593
L1CAM interactions	R-HSA-373760	2.552411e-03	2.593
Peptide chain elongation	R-HSA-156902	2.567778e-03	2.590
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	2.673224e-03	2.573
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	2.975361e-03	2.526
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	3.088814e-03	2.510
RNA Polymerase I Promoter Opening	R-HSA-73728	3.088814e-03	2.510
Packaging Of Telomere Ends	R-HSA-171306	3.088814e-03	2.510
Signaling by NTRK2 (TRKB)	R-HSA-9006115	3.088814e-03	2.510
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	3.099403e-03	2.509
NOD1/2 Signaling Pathway	R-HSA-168638	3.099403e-03	2.509
Regulation of PD-L1(CD274) expression	R-HSA-9909648	3.103293e-03	2.508
Semaphorin interactions	R-HSA-373755	3.115772e-03	2.506
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	3.226415e-03	2.491
Signaling by AXIN mutants	R-HSA-4839735	3.271587e-03	2.485
Signaling by GSK3beta mutants	R-HSA-5339716	3.271587e-03	2.485
Signaling by EGFRvIII in Cancer	R-HSA-5637812	3.363713e-03	2.473
Constitutive Signaling by EGFRvIII	R-HSA-5637810	3.363713e-03	2.473
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	3.573252e-03	2.447
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	3.581497e-03	2.446
Activation of the AP-1 family of transcription factors	R-HSA-450341	3.581497e-03	2.446
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	3.581497e-03	2.446
Regulation of NFE2L2 gene expression	R-HSA-9818749	3.610315e-03	2.442
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	3.610315e-03	2.442
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	4.047249e-03	2.393
p38MAPK events	R-HSA-171007	4.047249e-03	2.393
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	3.728275e-03	2.428
Defective pyroptosis	R-HSA-9710421	4.328711e-03	2.364
Signaling by ERBB4	R-HSA-1236394	4.202248e-03	2.377
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	4.002013e-03	2.398
Nonsense-Mediated Decay (NMD)	R-HSA-927802	3.926237e-03	2.406
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	3.926237e-03	2.406
mRNA Splicing	R-HSA-72172	3.867299e-03	2.413
Signaling by FGFR1	R-HSA-5654736	4.256552e-03	2.371
Macroautophagy	R-HSA-1632852	3.791720e-03	2.421
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	4.108196e-03	2.386
p75 NTR receptor-mediated signalling	R-HSA-193704	4.126610e-03	2.384
MITF-M-dependent gene expression	R-HSA-9856651	3.806367e-03	2.419
Influenza Infection	R-HSA-168255	3.720824e-03	2.429
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	4.398793e-03	2.357
Chaperone Mediated Autophagy	R-HSA-9613829	4.562411e-03	2.341
RNA Polymerase II Transcription Termination	R-HSA-73856	4.638415e-03	2.334
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	4.646537e-03	2.333
Glycolysis	R-HSA-70171	4.666636e-03	2.331
FLT3 signaling in disease	R-HSA-9682385	4.749236e-03	2.323
RUNX3 regulates p14-ARF	R-HSA-8951936	4.781217e-03	2.320
SHC-related events triggered by IGF1R	R-HSA-2428933	4.781217e-03	2.320
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	4.781217e-03	2.320
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	4.781217e-03	2.320
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	4.781217e-03	2.320
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	4.781217e-03	2.320
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	4.781217e-03	2.320
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	4.860255e-03	2.313
Regulation of MECP2 expression and activity	R-HSA-9022692	4.902460e-03	2.310
Cellular responses to mechanical stimuli	R-HSA-9855142	4.941590e-03	2.306
VEGFR2 mediated cell proliferation	R-HSA-5218921	4.989028e-03	2.302
DNA methylation	R-HSA-5334118	4.991484e-03	2.302
Impaired BRCA2 binding to RAD51	R-HSA-9709570	4.991484e-03	2.302
Reproduction	R-HSA-1474165	5.114503e-03	2.291
EPHB-mediated forward signaling	R-HSA-3928662	5.210495e-03	2.283
Adherens junctions interactions	R-HSA-418990	5.229132e-03	2.282
Deubiquitination	R-HSA-5688426	5.348128e-03	2.272
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	5.410240e-03	2.267
Signal attenuation	R-HSA-74749	5.480581e-03	2.261
Pexophagy	R-HSA-9664873	5.480581e-03	2.261
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	5.480581e-03	2.261
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	5.480581e-03	2.261
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	5.520231e-03	2.258
Organelle biogenesis and maintenance	R-HSA-1852241	5.758008e-03	2.240
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	5.951122e-03	2.225
SOS-mediated signalling	R-HSA-112412	5.951122e-03	2.225
Regulation of PTEN localization	R-HSA-8948747	5.951122e-03	2.225
Impaired BRCA2 binding to PALB2	R-HSA-9709603	6.073953e-03	2.217
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	6.233531e-03	2.205
mTORC1-mediated signalling	R-HSA-166208	6.300742e-03	2.201
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	6.339813e-03	2.198
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	8.048714e-03	2.094
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	8.048714e-03	2.094
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	8.048714e-03	2.094
GRB2 events in ERBB2 signaling	R-HSA-1963640	7.557847e-03	2.122
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	7.949207e-03	2.100
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	7.949207e-03	2.100
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	7.949207e-03	2.100
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	7.949207e-03	2.100
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	7.964244e-03	2.099
Regulation of RAS by GAPs	R-HSA-5658442	6.883351e-03	2.162
HDACs deacetylate histones	R-HSA-3214815	7.467798e-03	2.127
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	7.540058e-03	2.123
Mitophagy	R-HSA-5205647	7.420554e-03	2.130
HIV Life Cycle	R-HSA-162587	7.397756e-03	2.131
Chromatin organization	R-HSA-4839726	7.471407e-03	2.127
Chromatin modifying enzymes	R-HSA-3247509	7.972816e-03	2.098
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	7.540058e-03	2.123
Signaling by APC mutants	R-HSA-4839744	8.048714e-03	2.094
Negative regulation of MET activity	R-HSA-6807004	7.949207e-03	2.100
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	7.313813e-03	2.136
Depurination	R-HSA-73927	7.049560e-03	2.152
Cleavage of the damaged pyrimidine	R-HSA-110329	7.954549e-03	2.099
Depyrimidination	R-HSA-73928	7.954549e-03	2.099
SARS-CoV Infections	R-HSA-9679506	7.629687e-03	2.117
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	7.413568e-03	2.130
Formation of a pool of free 40S subunits	R-HSA-72689	8.122550e-03	2.090
Ub-specific processing proteases	R-HSA-5689880	8.491645e-03	2.071
TNF signaling	R-HSA-75893	8.711989e-03	2.060
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	9.016859e-03	2.045
SARS-CoV-2 Infection	R-HSA-9694516	9.108140e-03	2.041
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	9.240119e-03	2.034
RSK activation	R-HSA-444257	9.240119e-03	2.034
Activation of RAS in B cells	R-HSA-1169092	9.240119e-03	2.034
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	9.240119e-03	2.034
Signaling by FGFR4 in disease	R-HSA-5655291	9.339500e-03	2.030
Signaling by MET	R-HSA-6806834	9.476272e-03	2.023
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	9.487178e-03	2.023
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	9.496325e-03	2.022
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	9.897522e-03	2.004
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	9.907113e-03	2.004
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	9.907113e-03	2.004
Specification of primordial germ cells	R-HSA-9827857	1.001058e-02	2.000
SARS-CoV-1 Infection	R-HSA-9678108	1.002866e-02	1.999
Inhibition of DNA recombination at telomere	R-HSA-9670095	1.016557e-02	1.993
Signalling to RAS	R-HSA-167044	1.024109e-02	1.990
ERK/MAPK targets	R-HSA-198753	1.024109e-02	1.990
Toll-like Receptor Cascades	R-HSA-168898	1.030711e-02	1.987
HIV Infection	R-HSA-162906	1.035846e-02	1.985
Immune System	R-HSA-168256	1.052436e-02	1.978
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.066401e-02	1.972
Amyloid fiber formation	R-HSA-977225	1.073393e-02	1.969
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	1.106493e-02	1.956
HDR through Homologous Recombination (HRR)	R-HSA-5685942	1.113143e-02	1.953
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	1.114184e-02	1.953
Netrin-1 signaling	R-HSA-373752	1.117998e-02	1.952
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.140933e-02	1.943
Activation of RAC1	R-HSA-428540	1.140933e-02	1.943
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	1.140933e-02	1.943
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	1.140933e-02	1.943
Signaling by AMER1 mutants	R-HSA-4839748	1.140933e-02	1.943
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	1.150738e-02	1.939
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	1.152631e-02	1.938
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	1.155411e-02	1.937
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	1.206387e-02	1.919
p53-Dependent G1 DNA Damage Response	R-HSA-69563	1.206387e-02	1.919
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.206387e-02	1.919
Transcriptional Regulation by VENTX	R-HSA-8853884	1.208505e-02	1.918
Signaling by Erythropoietin	R-HSA-9006335	1.217592e-02	1.914
Transcriptional activation of p53 responsive genes	R-HSA-69560	1.647570e-02	1.783
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	1.647570e-02	1.783
AKT-mediated inactivation of FOXO1A	R-HSA-211163	1.647570e-02	1.783
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	1.647570e-02	1.783
Signaling by MAP2K mutants	R-HSA-9652169	1.647570e-02	1.783
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.570795e-02	1.804
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	1.365686e-02	1.865
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.365686e-02	1.865
Spry regulation of FGF signaling	R-HSA-1295596	1.256593e-02	1.901
Erythropoietin activates RAS	R-HSA-9027284	1.256593e-02	1.901
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	1.256593e-02	1.901
Beta-catenin phosphorylation cascade	R-HSA-196299	1.256593e-02	1.901
Prolonged ERK activation events	R-HSA-169893	1.654218e-02	1.781
Polo-like kinase mediated events	R-HSA-156711	1.301904e-02	1.885
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	1.301904e-02	1.885
Regulation of TP53 Activity through Methylation	R-HSA-6804760	1.301904e-02	1.885
Germ layer formation at gastrulation	R-HSA-9754189	1.665132e-02	1.779
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	1.629130e-02	1.788
Metalloprotease DUBs	R-HSA-5689901	1.564612e-02	1.806
DAP12 signaling	R-HSA-2424491	1.483635e-02	1.829
Metabolism of non-coding RNA	R-HSA-194441	1.347154e-02	1.871
snRNP Assembly	R-HSA-191859	1.347154e-02	1.871
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	1.250099e-02	1.903
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	1.551620e-02	1.809
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	1.640062e-02	1.785
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	1.407109e-02	1.852
Cyclin E associated events during G1/S transition	R-HSA-69202	1.640062e-02	1.785
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	1.629130e-02	1.788
Regulation of signaling by CBL	R-HSA-912631	1.665132e-02	1.779
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	1.546590e-02	1.811
Cap-dependent Translation Initiation	R-HSA-72737	1.270364e-02	1.896
Eukaryotic Translation Initiation	R-HSA-72613	1.270364e-02	1.896
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	1.274618e-02	1.895
Regulation of PTEN gene transcription	R-HSA-8943724	1.544870e-02	1.811
Signaling by FLT3 fusion proteins	R-HSA-9703465	1.564612e-02	1.806
Long-term potentiation	R-HSA-9620244	1.268489e-02	1.897
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	1.544870e-02	1.811
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	1.544870e-02	1.811
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	1.544870e-02	1.811
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	1.544870e-02	1.811
Pre-NOTCH Transcription and Translation	R-HSA-1912408	1.250099e-02	1.903
Listeria monocytogenes entry into host cells	R-HSA-8876384	1.300370e-02	1.886
Signaling by NTRK3 (TRKC)	R-HSA-9034015	1.300370e-02	1.886
Selenocysteine synthesis	R-HSA-2408557	1.567002e-02	1.805
Signaling by NOTCH1 in Cancer	R-HSA-2644603	1.544870e-02	1.811
Negative regulation of FLT3	R-HSA-9706369	1.654218e-02	1.781
Kinesins	R-HSA-983189	1.544870e-02	1.811
Diseases of DNA repair	R-HSA-9675135	1.535624e-02	1.814
Signaling by PDGFR in disease	R-HSA-9671555	1.300370e-02	1.886
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	1.256593e-02	1.901
Cleavage of the damaged purine	R-HSA-110331	1.301277e-02	1.886
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.427643e-02	1.845
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	1.668912e-02	1.778
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	1.668912e-02	1.778
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	1.668912e-02	1.778
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	1.668912e-02	1.778
Ca-dependent events	R-HSA-111996	1.676337e-02	1.776
Signaling by FGFR2	R-HSA-5654738	1.699001e-02	1.770
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	1.699742e-02	1.770
Signaling by NOTCH	R-HSA-157118	1.747044e-02	1.758
EGFR downregulation	R-HSA-182971	1.791586e-02	1.747
Trafficking of AMPA receptors	R-HSA-399719	1.791586e-02	1.747
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	1.853656e-02	1.732
RNA Polymerase I Promoter Escape	R-HSA-73772	1.875486e-02	1.727
Late Phase of HIV Life Cycle	R-HSA-162599	1.879899e-02	1.726
RNA Polymerase I Promoter Clearance	R-HSA-73854	1.883266e-02	1.725
CD28 dependent PI3K/Akt signaling	R-HSA-389357	1.909759e-02	1.719
EGFR Transactivation by Gastrin	R-HSA-2179392	1.936824e-02	1.713
Regulation of CDH1 Function	R-HSA-9764561	1.949040e-02	1.710
TBC/RABGAPs	R-HSA-8854214	1.956964e-02	1.708
Response of Mtb to phagocytosis	R-HSA-9637690	1.956964e-02	1.708
Negative regulation of the PI3K/AKT network	R-HSA-199418	1.973288e-02	1.705
Co-inhibition by PD-1	R-HSA-389948	2.003610e-02	1.698
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	2.007877e-02	1.697
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	2.064941e-02	1.685
Formation of definitive endoderm	R-HSA-9823730	2.097372e-02	1.678
Frs2-mediated activation	R-HSA-170968	2.098540e-02	1.678
CD28 dependent Vav1 pathway	R-HSA-389359	2.098540e-02	1.678
SHC1 events in ERBB4 signaling	R-HSA-1250347	2.135320e-02	1.671
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	2.135320e-02	1.671
Activation of AMPK downstream of NMDARs	R-HSA-9619483	2.308255e-02	1.637
Regulated Necrosis	R-HSA-5218859	2.316653e-02	1.635
Calmodulin induced events	R-HSA-111933	2.339278e-02	1.631
CaM pathway	R-HSA-111997	2.339278e-02	1.631
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	2.342019e-02	1.630
Cation-coupled Chloride cotransporters	R-HSA-426117	2.342019e-02	1.630
Eukaryotic Translation Termination	R-HSA-72764	2.360246e-02	1.627
RNA Polymerase I Transcription	R-HSA-73864	2.363750e-02	1.626
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	2.417977e-02	1.617
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	2.443632e-02	1.612
Base-Excision Repair, AP Site Formation	R-HSA-73929	2.459604e-02	1.609
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	2.465371e-02	1.608
Neurodegenerative Diseases	R-HSA-8863678	2.465371e-02	1.608
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	2.497117e-02	1.603
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	2.497117e-02	1.603
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	2.547802e-02	1.594
Regulation of necroptotic cell death	R-HSA-5675482	2.547802e-02	1.594
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	2.547802e-02	1.594
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	2.547802e-02	1.594
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	2.547802e-02	1.594
Assembly of the ORC complex at the origin of replication	R-HSA-68616	2.547802e-02	1.594
Insulin receptor signalling cascade	R-HSA-74751	2.571078e-02	1.590
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	2.604929e-02	1.584
DAG and IP3 signaling	R-HSA-1489509	2.623438e-02	1.581
Regulation of localization of FOXO transcription factors	R-HSA-9614399	2.652134e-02	1.576
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	2.652134e-02	1.576
Activated NTRK3 signals through RAS	R-HSA-9034864	2.652134e-02	1.576
Suppression of apoptosis	R-HSA-9635465	2.652134e-02	1.576
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	2.699839e-02	1.569
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	2.699839e-02	1.569
IRS activation	R-HSA-74713	2.699839e-02	1.569
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.699839e-02	1.569
FLT3 signaling by CBL mutants	R-HSA-9706377	2.699839e-02	1.569
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	2.705921e-02	1.568
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	2.705921e-02	1.568
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	2.705921e-02	1.568
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	2.705921e-02	1.568
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	2.705921e-02	1.568
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	2.705921e-02	1.568
Signaling by RAS GAP mutants	R-HSA-9753510	2.705921e-02	1.568
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	2.705921e-02	1.568
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	2.705921e-02	1.568
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	2.705921e-02	1.568
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	2.705921e-02	1.568
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	2.705921e-02	1.568
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	2.705921e-02	1.568
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	2.705921e-02	1.568
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	2.707812e-02	1.567
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	2.741913e-02	1.562
NRIF signals cell death from the nucleus	R-HSA-205043	2.741913e-02	1.562
Downstream signaling of activated FGFR3	R-HSA-5654708	2.764262e-02	1.558
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	2.764262e-02	1.558
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	2.854779e-02	1.544
Degradation of beta-catenin by the destruction complex	R-HSA-195253	2.918797e-02	1.535
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	2.918797e-02	1.535
Adaptive Immune System	R-HSA-1280218	2.930083e-02	1.533
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	2.933324e-02	1.533
Tight junction interactions	R-HSA-420029	2.982913e-02	1.525
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	2.982913e-02	1.525
TGFBR3 expression	R-HSA-9839394	2.982913e-02	1.525
Resolution of D-Loop Structures	R-HSA-5693537	3.003090e-02	1.522
Condensation of Prophase Chromosomes	R-HSA-2299718	3.013882e-02	1.521
Regulation of TNFR1 signaling	R-HSA-5357905	3.013882e-02	1.521
S Phase	R-HSA-69242	3.014568e-02	1.521
Activation, translocation and oligomerization of BAX	R-HSA-114294	4.128661e-02	1.384
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	4.128661e-02	1.384
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	4.128661e-02	1.384
Diseases of Telomere Maintenance	R-HSA-9673013	4.128661e-02	1.384
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	4.128661e-02	1.384
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	4.128661e-02	1.384
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	4.128661e-02	1.384
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	4.128661e-02	1.384
ROBO receptors bind AKAP5	R-HSA-9010642	3.322902e-02	1.478
Myoclonic epilepsy of Lafora	R-HSA-3785653	3.322902e-02	1.478
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	4.525971e-02	1.344
Inactivation of CDC42 and RAC1	R-HSA-428543	4.525971e-02	1.344
Activated NTRK2 signals through RAS	R-HSA-9026519	3.523774e-02	1.453
NF-kB is activated and signals survival	R-HSA-209560	3.523774e-02	1.453
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	4.560955e-02	1.341
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	4.560955e-02	1.341
IRAK1 recruits IKK complex	R-HSA-937039	4.560955e-02	1.341
ERBB2 Regulates Cell Motility	R-HSA-6785631	3.507482e-02	1.455
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	4.402628e-02	1.356
FOXO-mediated transcription of cell death genes	R-HSA-9614657	3.378820e-02	1.471
Signaling by KIT in disease	R-HSA-9669938	3.868744e-02	1.412
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	3.868744e-02	1.412
Downstream signaling of activated FGFR4	R-HSA-5654716	3.281713e-02	1.484
Stabilization of p53	R-HSA-69541	3.691953e-02	1.433
Cyclin D associated events in G1	R-HSA-69231	4.362117e-02	1.360
G1 Phase	R-HSA-69236	4.362117e-02	1.360
Regulation of RUNX2 expression and activity	R-HSA-8939902	3.217531e-02	1.492
Translation initiation complex formation	R-HSA-72649	4.486797e-02	1.348
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	4.024765e-02	1.395
IGF1R signaling cascade	R-HSA-2428924	4.509979e-02	1.346
Signaling by NOTCH4	R-HSA-9013694	4.465393e-02	1.350
HCMV Early Events	R-HSA-9609690	4.446455e-02	1.352
Nuclear events mediated by NFE2L2	R-HSA-9759194	3.169158e-02	1.499
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.199456e-02	1.377
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	4.402628e-02	1.356
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	3.171361e-02	1.499
FOXO-mediated transcription	R-HSA-9614085	3.447974e-02	1.462
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	4.084235e-02	1.389
Ion homeostasis	R-HSA-5578775	3.171361e-02	1.499
HSF1-dependent transactivation	R-HSA-3371571	3.104734e-02	1.508
Myogenesis	R-HSA-525793	3.572887e-02	1.447
RAS processing	R-HSA-9648002	3.691953e-02	1.433
PTEN Regulation	R-HSA-6807070	3.155759e-02	1.501
G-protein mediated events	R-HSA-112040	3.629766e-02	1.440
Hedgehog 'off' state	R-HSA-5610787	3.771101e-02	1.424
Signaling by LTK	R-HSA-9842663	4.560955e-02	1.341
Apoptotic factor-mediated response	R-HSA-111471	3.378820e-02	1.471
PLC beta mediated events	R-HSA-112043	3.217531e-02	1.492
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	3.445404e-02	1.463
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	3.193640e-02	1.496
Budding and maturation of HIV virion	R-HSA-162588	3.864243e-02	1.413
rRNA processing in the nucleus and cytosol	R-HSA-8868773	3.797340e-02	1.421
Intrinsic Pathway for Apoptosis	R-HSA-109606	3.171361e-02	1.499
Mitotic G1 phase and G1/S transition	R-HSA-453279	3.849051e-02	1.415
p75NTR signals via NF-kB	R-HSA-193639	3.507482e-02	1.455
Downstream signal transduction	R-HSA-186763	3.864243e-02	1.413
Platelet sensitization by LDL	R-HSA-432142	3.378820e-02	1.471
Transport of connexons to the plasma membrane	R-HSA-190872	3.378820e-02	1.471
Mitochondrial biogenesis	R-HSA-1592230	3.509042e-02	1.455
G alpha (12/13) signalling events	R-HSA-416482	4.008486e-02	1.397
Signaling by NOTCH1	R-HSA-1980143	3.262745e-02	1.486
Signaling by Nuclear Receptors	R-HSA-9006931	4.507193e-02	1.346
Maternal to zygotic transition (MZT)	R-HSA-9816359	3.726721e-02	1.429
p75NTR recruits signalling complexes	R-HSA-209543	4.560955e-02	1.341
Interleukin-1 family signaling	R-HSA-446652	4.026023e-02	1.395
Cilium Assembly	R-HSA-5617833	4.306240e-02	1.366
Heme signaling	R-HSA-9707616	3.613335e-02	1.442
Signaling by ALK	R-HSA-201556	3.691953e-02	1.433
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	4.026023e-02	1.395
Smooth Muscle Contraction	R-HSA-445355	3.985026e-02	1.400
tRNA processing in the nucleus	R-HSA-6784531	3.613335e-02	1.442
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	3.378820e-02	1.471
Glucose metabolism	R-HSA-70326	3.509042e-02	1.455
Maturation of protein E	R-HSA-9694493	4.077211e-02	1.390
Maturation of protein E	R-HSA-9683683	4.077211e-02	1.390
Signaling by TGF-beta Receptor Complex	R-HSA-170834	4.570350e-02	1.340
RUNX2 regulates bone development	R-HSA-8941326	4.715834e-02	1.326
Viral mRNA Translation	R-HSA-192823	4.876079e-02	1.312
Protein ubiquitination	R-HSA-8852135	4.930504e-02	1.307
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	4.950720e-02	1.305
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	4.950720e-02	1.305
Negative regulation of FGFR3 signaling	R-HSA-5654732	4.985843e-02	1.302
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	5.013555e-02	1.300
Post-chaperonin tubulin folding pathway	R-HSA-389977	5.039874e-02	1.298
Co-inhibition by CTLA4	R-HSA-389513	5.039874e-02	1.298
Nephrin family interactions	R-HSA-373753	5.039874e-02	1.298
Signal transduction by L1	R-HSA-445144	5.039874e-02	1.298
Activation of ATR in response to replication stress	R-HSA-176187	5.237238e-02	1.281
Integrin signaling	R-HSA-354192	5.237238e-02	1.281
FGFR1 mutant receptor activation	R-HSA-1839124	5.237238e-02	1.281
HATs acetylate histones	R-HSA-3214847	5.410765e-02	1.267
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	5.411428e-02	1.267
Ovarian tumor domain proteases	R-HSA-5689896	5.411428e-02	1.267
SIRT1 negatively regulates rRNA expression	R-HSA-427359	5.411428e-02	1.267
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	5.432897e-02	1.265
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	5.432897e-02	1.265
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	5.432897e-02	1.265
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	5.495449e-02	1.260
NoRC negatively regulates rRNA expression	R-HSA-427413	5.498349e-02	1.260
Signaling by TGFBR3	R-HSA-9839373	5.592190e-02	1.252
Viral Messenger RNA Synthesis	R-HSA-168325	5.597973e-02	1.252
Ribosomal scanning and start codon recognition	R-HSA-72702	5.621580e-02	1.250
Transcriptional Regulation by MECP2	R-HSA-8986944	5.643015e-02	1.248
Circadian clock	R-HSA-9909396	5.683549e-02	1.245
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	5.769692e-02	1.239
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	5.769692e-02	1.239
Signaling by LTK in cancer	R-HSA-9842640	5.786162e-02	1.238
Nef and signal transduction	R-HSA-164944	5.786162e-02	1.238
CREB phosphorylation	R-HSA-199920	5.786162e-02	1.238
Signaling by CSF3 (G-CSF)	R-HSA-9674555	5.815275e-02	1.235
Negative regulation of FGFR4 signaling	R-HSA-5654733	5.815275e-02	1.235
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	5.815275e-02	1.235
Regulation of gene expression in beta cells	R-HSA-210745	5.815275e-02	1.235
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	5.957560e-02	1.225
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	5.957560e-02	1.225
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	5.957560e-02	1.225
Josephin domain DUBs	R-HSA-5689877	5.957560e-02	1.225
Cellular response to starvation	R-HSA-9711097	5.996628e-02	1.222
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	6.038747e-02	1.219
RIPK1-mediated regulated necrosis	R-HSA-5213460	6.173054e-02	1.209
Extra-nuclear estrogen signaling	R-HSA-9009391	6.356481e-02	1.197
Sema4D in semaphorin signaling	R-HSA-400685	6.453613e-02	1.190
Neutrophil degranulation	R-HSA-6798695	6.510547e-02	1.186
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	6.580314e-02	1.182
PI3K events in ERBB2 signaling	R-HSA-1963642	6.601872e-02	1.180
Chromosome Maintenance	R-HSA-73886	7.113738e-02	1.148
Regulation of KIT signaling	R-HSA-1433559	7.152721e-02	1.146
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	7.152721e-02	1.146
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	7.152721e-02	1.146
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	7.153594e-02	1.145
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	7.153594e-02	1.145
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	7.153594e-02	1.145
Assembly of the pre-replicative complex	R-HSA-68867	7.232350e-02	1.141
Dopamine receptors	R-HSA-390651	7.263327e-02	1.139
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	7.263327e-02	1.139
PLCG1 events in ERBB2 signaling	R-HSA-1251932	7.263327e-02	1.139
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	7.263327e-02	1.139
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	7.263327e-02	1.139
GRB7 events in ERBB2 signaling	R-HSA-1306955	7.263327e-02	1.139
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	7.263327e-02	1.139
Signaling by FGFR in disease	R-HSA-1226099	7.283098e-02	1.138
Pre-NOTCH Expression and Processing	R-HSA-1912422	7.537908e-02	1.123
MAPK6/MAPK4 signaling	R-HSA-5687128	7.596954e-02	1.119
Signaling by FGFR	R-HSA-190236	7.616737e-02	1.118
PECAM1 interactions	R-HSA-210990	7.617982e-02	1.118
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	7.617982e-02	1.118
Interleukin-2 signaling	R-HSA-9020558	7.617982e-02	1.118
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	7.731350e-02	1.112
IFNG signaling activates MAPKs	R-HSA-9732724	7.819993e-02	1.107
Cohesin Loading onto Chromatin	R-HSA-2470946	7.819993e-02	1.107
Disinhibition of SNARE formation	R-HSA-114516	7.819993e-02	1.107
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	7.819993e-02	1.107
MECP2 regulates transcription factors	R-HSA-9022707	7.819993e-02	1.107
Downstream signaling of activated FGFR1	R-HSA-5654687	7.852346e-02	1.105
Downstream signaling of activated FGFR2	R-HSA-5654696	7.852346e-02	1.105
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	7.852346e-02	1.105
Tie2 Signaling	R-HSA-210993	7.911118e-02	1.102
Base Excision Repair	R-HSA-73884	8.033704e-02	1.095
Cellular response to chemical stress	R-HSA-9711123	8.104998e-02	1.091
Platelet activation, signaling and aggregation	R-HSA-76002	8.216030e-02	1.085
DNA Replication Pre-Initiation	R-HSA-69002	8.331854e-02	1.079
Defective Base Excision Repair Associated with OGG1	R-HSA-9656249	8.382784e-02	1.077
Manipulation of host energy metabolism	R-HSA-9636667	8.382784e-02	1.077
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	8.382784e-02	1.077
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	8.382784e-02	1.077
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	8.382784e-02	1.077
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	8.382784e-02	1.077
Breakdown of the nuclear lamina	R-HSA-352238	8.382784e-02	1.077
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	8.385530e-02	1.076
Signaling by NOTCH3	R-HSA-9012852	8.592408e-02	1.066
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	8.669040e-02	1.062
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	8.669040e-02	1.062
Signaling by FGFR3 in disease	R-HSA-5655332	8.669040e-02	1.062
DCC mediated attractive signaling	R-HSA-418885	8.709533e-02	1.060
Translesion synthesis by REV1	R-HSA-110312	8.709533e-02	1.060
Activation of BAD and translocation to mitochondria	R-HSA-111447	8.709533e-02	1.060
SHC1 events in EGFR signaling	R-HSA-180336	8.709533e-02	1.060
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	8.709533e-02	1.060
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	8.709533e-02	1.060
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	8.709533e-02	1.060
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	8.709533e-02	1.060
Signaling by WNT in cancer	R-HSA-4791275	8.820407e-02	1.055
TCR signaling	R-HSA-202403	8.933705e-02	1.049
Ribosome-associated quality control	R-HSA-9948299	8.972175e-02	1.047
Clathrin-mediated endocytosis	R-HSA-8856828	9.223514e-02	1.035
IKK complex recruitment mediated by RIP1	R-HSA-937041	9.360179e-02	1.029
Transmission across Chemical Synapses	R-HSA-112315	9.371092e-02	1.028
Signaling by TGFB family members	R-HSA-9006936	9.381669e-02	1.028
ERKs are inactivated	R-HSA-202670	9.501964e-02	1.022
Cytochrome c-mediated apoptotic response	R-HSA-111461	9.501964e-02	1.022
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	9.668941e-02	1.015
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	9.734303e-02	1.012
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	9.787715e-02	1.009
C-type lectin receptors (CLRs)	R-HSA-5621481	9.798957e-02	1.009
G1/S Transition	R-HSA-69206	9.887428e-02	1.005
Degradation of GLI1 by the proteasome	R-HSA-5610780	9.906308e-02	1.004
Degradation of GLI2 by the proteasome	R-HSA-5610783	9.906308e-02	1.004
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	9.997195e-02	1.000
Negative regulation of FGFR1 signaling	R-HSA-5654726	9.997195e-02	1.000
Parasite infection	R-HSA-9664407	1.010828e-01	0.995
Leishmania phagocytosis	R-HSA-9664417	1.010828e-01	0.995
FCGR3A-mediated phagocytosis	R-HSA-9664422	1.010828e-01	0.995
Signaling by MRAS-complex mutants	R-HSA-9660537	1.016109e-01	0.993
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	1.016109e-01	0.993
Adrenoceptors	R-HSA-390696	1.016109e-01	0.993
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	1.016109e-01	0.993
Modulation by Mtb of host immune system	R-HSA-9637628	1.016109e-01	0.993
PI Metabolism	R-HSA-1483255	1.018567e-01	0.992
Inositol phosphate metabolism	R-HSA-1483249	1.022210e-01	0.990
DNA Repair	R-HSA-73894	1.022555e-01	0.990
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	1.030291e-01	0.987
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	1.030291e-01	0.987
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	1.030291e-01	0.987
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	1.030291e-01	0.987
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	1.030291e-01	0.987
SMAC (DIABLO) binds to IAPs	R-HSA-111463	1.030291e-01	0.987
Vesicle-mediated transport	R-HSA-5653656	1.039065e-01	0.983
Differentiation of T cells	R-HSA-9945266	1.043654e-01	0.981
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	1.043654e-01	0.981
Translesion synthesis by POLI	R-HSA-5656121	1.043654e-01	0.981
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	1.043654e-01	0.981
Regulation of NF-kappa B signaling	R-HSA-9758274	1.043654e-01	0.981
Regulation of BACH1 activity	R-HSA-9708530	1.043654e-01	0.981
Interferon Signaling	R-HSA-913531	1.049886e-01	0.979
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	1.062047e-01	0.974
Viral Infection Pathways	R-HSA-9824446	1.070218e-01	0.971
Cardiac conduction	R-HSA-5576891	1.080330e-01	0.966
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.094665e-01	0.961
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.094665e-01	0.961
Signaling by NODAL	R-HSA-1181150	1.094665e-01	0.961
Beta-catenin independent WNT signaling	R-HSA-3858494	1.107566e-01	0.956
Drug resistance of KIT mutants	R-HSA-9669937	1.475175e-01	0.831
KIT mutants bind TKIs	R-HSA-9669921	1.475175e-01	0.831
Regorafenib-resistant KIT mutants	R-HSA-9669929	1.475175e-01	0.831
Deletions in the AXIN1 gene destabilize the destruction complex	R-HSA-5467345	1.475175e-01	0.831
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	1.475175e-01	0.831
Masitinib-resistant KIT mutants	R-HSA-9669924	1.475175e-01	0.831
Loss of Function of TP53 in Cancer	R-HSA-9723907	1.475175e-01	0.831
Sorafenib-resistant KIT mutants	R-HSA-9669936	1.475175e-01	0.831
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects	R-HSA-9646304	1.475175e-01	0.831
Evasion of Oncogene Induced Senescence Due to p14ARF Defects	R-HSA-9646303	1.475175e-01	0.831
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	1.475175e-01	0.831
Defective OGG1 Localization	R-HSA-9657050	1.475175e-01	0.831
Defective OGG1 Substrate Binding	R-HSA-9656255	1.475175e-01	0.831
Sunitinib-resistant KIT mutants	R-HSA-9669934	1.475175e-01	0.831
Nilotinib-resistant KIT mutants	R-HSA-9669926	1.475175e-01	0.831
Imatinib-resistant KIT mutants	R-HSA-9669917	1.475175e-01	0.831
Dasatinib-resistant KIT mutants	R-HSA-9669914	1.475175e-01	0.831
Regulation of TP53 Expression	R-HSA-6804754	1.346823e-01	0.871
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	1.346823e-01	0.871
Diseases of cellular response to stress	R-HSA-9675132	1.346823e-01	0.871
DSCAM interactions	R-HSA-376172	1.346823e-01	0.871
Diseases of Cellular Senescence	R-HSA-9630747	1.346823e-01	0.871
Potassium transport channels	R-HSA-1296067	1.346823e-01	0.871
MET interacts with TNS proteins	R-HSA-8875513	1.904735e-01	0.720
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	1.904735e-01	0.720
Classical Kir channels	R-HSA-1296053	1.904735e-01	0.720
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	1.904735e-01	0.720
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	1.904735e-01	0.720
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	1.375333e-01	0.862
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	1.375333e-01	0.862
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	1.375333e-01	0.862
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	1.375333e-01	0.862
IkBA variant leads to EDA-ID	R-HSA-5603029	1.375333e-01	0.862
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	1.278333e-01	0.893
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	1.278333e-01	0.893
Gap junction degradation	R-HSA-190873	1.278333e-01	0.893
ALK mutants bind TKIs	R-HSA-9700645	1.278333e-01	0.893
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	1.753219e-01	0.756
RUNX3 regulates NOTCH signaling	R-HSA-8941856	1.159928e-01	0.936
Role of second messengers in netrin-1 signaling	R-HSA-418890	1.159928e-01	0.936
MET activates RAP1 and RAC1	R-HSA-8875555	1.565443e-01	0.805
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	2.155697e-01	0.666
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	2.155697e-01	0.666
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	2.155697e-01	0.666
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	1.389548e-01	0.857
Formation of axial mesoderm	R-HSA-9796292	1.389548e-01	0.857
Translesion synthesis by POLK	R-HSA-5655862	1.232728e-01	0.909
CRMPs in Sema3A signaling	R-HSA-399956	1.637271e-01	0.786
SHC-mediated cascade:FGFR3	R-HSA-5654704	1.266626e-01	0.897
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	2.199574e-01	0.658
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	2.199574e-01	0.658
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	1.451305e-01	0.838
SHC-mediated cascade:FGFR4	R-HSA-5654719	1.451305e-01	0.838
Late endosomal microautophagy	R-HSA-9615710	1.128453e-01	0.948
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	1.273911e-01	0.895
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	1.888168e-01	0.724
Negative regulation of FGFR2 signaling	R-HSA-5654727	1.261067e-01	0.899
Cristae formation	R-HSA-8949613	1.624675e-01	0.789
Interleukin receptor SHC signaling	R-HSA-912526	1.855692e-01	0.731
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	2.131768e-01	0.671
Diseases of mitotic cell cycle	R-HSA-9675126	1.592745e-01	0.798
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	1.813102e-01	0.742
SHC-mediated cascade:FGFR1	R-HSA-5654688	2.073527e-01	0.683
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	1.166060e-01	0.933
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	1.663700e-01	0.779
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	2.216044e-01	0.654
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	1.818116e-01	0.740
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	2.133983e-01	0.671
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	1.269257e-01	0.896
IRS-related events triggered by IGF1R	R-HSA-2428928	1.463790e-01	0.835
IRS-mediated signalling	R-HSA-112399	1.638614e-01	0.786
Developmental Lineages of the Mammary Gland	R-HSA-9924644	1.477211e-01	0.831
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	1.376091e-01	0.861
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	1.376091e-01	0.861
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	1.587642e-01	0.799
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	1.881505e-01	0.725
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	1.376091e-01	0.861
Signaling by NOTCH2	R-HSA-1980145	2.133983e-01	0.671
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	1.116318e-01	0.952
Regulation of endogenous retroelements	R-HSA-9842860	2.025256e-01	0.694
Epigenetic regulation of gene expression	R-HSA-212165	1.769644e-01	0.752
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	1.266626e-01	0.897
G0 and Early G1	R-HSA-1538133	1.592745e-01	0.798
Translesion Synthesis by POLH	R-HSA-110320	1.888168e-01	0.724
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	1.753219e-01	0.756
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	1.765285e-01	0.753
Telomere Maintenance	R-HSA-157579	2.105435e-01	0.677
Platelet Aggregation (Plug Formation)	R-HSA-76009	1.474810e-01	0.831
Interleukin-2 family signaling	R-HSA-451927	1.375416e-01	0.862
Regulation of PTEN stability and activity	R-HSA-8948751	1.166060e-01	0.933
Regulation of FZD by ubiquitination	R-HSA-4641263	1.437280e-01	0.842
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	2.073527e-01	0.683
Opioid Signalling	R-HSA-111885	1.165642e-01	0.933
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	1.421345e-01	0.847
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	1.375333e-01	0.862
Aryl hydrocarbon receptor signalling	R-HSA-8937144	1.375333e-01	0.862
Regulation of CDH11 function	R-HSA-9762292	1.565443e-01	0.805
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	1.232728e-01	0.909
CLEC7A (Dectin-1) signaling	R-HSA-5607764	1.991927e-01	0.701
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	1.477211e-01	0.831
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	1.278333e-01	0.893
VLDLR internalisation and degradation	R-HSA-8866427	1.159928e-01	0.936
Membrane binding and targetting of GAG proteins	R-HSA-174490	1.389548e-01	0.857
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	1.656193e-01	0.781
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	1.219104e-01	0.914
DARPP-32 events	R-HSA-180024	2.010487e-01	0.697
Gap junction trafficking and regulation	R-HSA-157858	1.310164e-01	0.883
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	1.192363e-01	0.924
Interleukin-1 signaling	R-HSA-9020702	1.916800e-01	0.717
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	1.159928e-01	0.936
Receptor Mediated Mitophagy	R-HSA-8934903	1.565443e-01	0.805
Gap junction trafficking	R-HSA-190828	1.343623e-01	0.872
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	1.774276e-01	0.751
HCMV Infection	R-HSA-9609646	2.007396e-01	0.697
Signaling by Hedgehog	R-HSA-5358351	2.193133e-01	0.659
GP1b-IX-V activation signalling	R-HSA-430116	1.278333e-01	0.893
Calcineurin activates NFAT	R-HSA-2025928	1.278333e-01	0.893
GRB2 events in EGFR signaling	R-HSA-179812	1.159928e-01	0.936
HDL assembly	R-HSA-8963896	1.637271e-01	0.786
Effects of PIP2 hydrolysis	R-HSA-114508	1.945895e-01	0.711
PI5P Regulates TP53 Acetylation	R-HSA-6811555	1.389548e-01	0.857
Gap junction assembly	R-HSA-190861	2.133983e-01	0.671
PCP/CE pathway	R-HSA-4086400	1.532222e-01	0.815
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	1.375333e-01	0.862
MET activates RAS signaling	R-HSA-8851805	1.159928e-01	0.936
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	1.637271e-01	0.786
Signaling by Activin	R-HSA-1502540	1.901052e-01	0.721
IRF3-mediated induction of type I IFN	R-HSA-3270619	1.901052e-01	0.721
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	1.901052e-01	0.721
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	1.283896e-01	0.891
Pyroptosis	R-HSA-5620971	1.813102e-01	0.742
Activation of BH3-only proteins	R-HSA-114452	1.273911e-01	0.895
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.565443e-01	0.805
DAP12 interactions	R-HSA-2172127	1.343623e-01	0.872
Neuronal System	R-HSA-112316	1.942877e-01	0.712
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization	R-HSA-180897	1.346823e-01	0.871
Activation of BIM and translocation to mitochondria	R-HSA-111446	1.904735e-01	0.720
Phase 3 - rapid repolarisation	R-HSA-5576890	2.155697e-01	0.666
Disorders of Developmental Biology	R-HSA-9675151	1.232728e-01	0.909
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	1.119831e-01	0.951
Depolymerization of the Nuclear Lamina	R-HSA-4419969	1.656193e-01	0.781
The NLRP3 inflammasome	R-HSA-844456	1.888168e-01	0.724
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	1.445922e-01	0.840
STING mediated induction of host immune responses	R-HSA-1834941	1.888168e-01	0.724
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	1.428801e-01	0.845
Cargo trafficking to the periciliary membrane	R-HSA-5620920	1.370988e-01	0.863
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	1.645957e-01	0.784
Uptake and function of diphtheria toxin	R-HSA-5336415	2.155697e-01	0.666
RAB geranylgeranylation	R-HSA-8873719	1.349868e-01	0.870
Displacement of DNA glycosylase by APEX1	R-HSA-110357	2.155697e-01	0.666
Transcriptional Regulation by NPAS4	R-HSA-9634815	1.696492e-01	0.770
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	1.266626e-01	0.897
Regulation of beta-cell development	R-HSA-186712	1.906917e-01	0.720
Ion channel transport	R-HSA-983712	2.222953e-01	0.653
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	1.159928e-01	0.936
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	1.159928e-01	0.936
Synthesis of PIPs in the nucleus	R-HSA-8847453	2.155697e-01	0.666
SLC-mediated transport of inorganic anions	R-HSA-9958790	1.881461e-01	0.726
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	1.982253e-01	0.703
Stimuli-sensing channels	R-HSA-2672351	1.587642e-01	0.799
ChREBP activates metabolic gene expression	R-HSA-163765	1.873806e-01	0.727
NPAS4 regulates expression of target genes	R-HSA-9768919	2.133983e-01	0.671
Regulation of CDH19 Expression and Function	R-HSA-9764302	1.375333e-01	0.862
Nuclear signaling by ERBB4	R-HSA-1251985	2.234658e-01	0.651
Regulation of RUNX3 expression and activity	R-HSA-8941858	2.234658e-01	0.651
Negative regulation of NOTCH4 signaling	R-HSA-9604323	2.234658e-01	0.651
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	2.250794e-01	0.648
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	2.385450e-01	0.622
TNFR1-induced proapoptotic signaling	R-HSA-5357786	2.385450e-01	0.622
Early Phase of HIV Life Cycle	R-HSA-162594	2.385450e-01	0.622
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	2.420310e-01	0.616
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	2.428921e-01	0.615
Evasion by RSV of host interferon responses	R-HSA-9833109	2.428921e-01	0.615
HCMV Late Events	R-HSA-9610379	2.431547e-01	0.614
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	2.467767e-01	0.608
PKR-mediated signaling	R-HSA-9833482	2.474865e-01	0.606
Regulation of gap junction activity	R-HSA-191650	2.486396e-01	0.604
TNFR1-mediated ceramide production	R-HSA-5626978	2.486396e-01	0.604
Inhibition of TSC complex formation by PKB	R-HSA-165181	2.486396e-01	0.604
Defective LFNG causes SCDO3	R-HSA-5083630	2.486396e-01	0.604
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	2.486396e-01	0.604
FLT3 signaling through SRC family kinases	R-HSA-9706374	2.486396e-01	0.604
GPVI-mediated activation cascade	R-HSA-114604	2.529967e-01	0.597
HSF1 activation	R-HSA-3371511	2.529967e-01	0.597
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	2.535095e-01	0.596
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	2.535095e-01	0.596
Suppression of phagosomal maturation	R-HSA-9637687	2.535095e-01	0.596
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	2.538843e-01	0.595
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	2.538843e-01	0.595
Repression of WNT target genes	R-HSA-4641265	2.538843e-01	0.595
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	2.538843e-01	0.595
Pervasive developmental disorders	R-HSA-9005895	2.538843e-01	0.595
Disorders of Nervous System Development	R-HSA-9697154	2.538843e-01	0.595
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	2.538843e-01	0.595
Type I hemidesmosome assembly	R-HSA-446107	2.574917e-01	0.589
Formation of annular gap junctions	R-HSA-196025	2.574917e-01	0.589
MET receptor recycling	R-HSA-8875656	2.574917e-01	0.589
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	2.574917e-01	0.589
Interleukin-9 signaling	R-HSA-8985947	2.574917e-01	0.589
Hemostasis	R-HSA-109582	2.598304e-01	0.585
FCERI mediated MAPK activation	R-HSA-2871796	2.627753e-01	0.580
FRS-mediated FGFR3 signaling	R-HSA-5654706	2.647605e-01	0.577
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	2.647605e-01	0.577
Assembly Of The HIV Virion	R-HSA-175474	2.647605e-01	0.577
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	2.648222e-01	0.577
Ion transport by P-type ATPases	R-HSA-936837	2.657234e-01	0.576
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	2.677787e-01	0.572
Golgi-to-ER retrograde transport	R-HSA-8856688	2.685771e-01	0.571
Defective OGG1 Substrate Processing	R-HSA-9656256	2.732807e-01	0.563
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	2.732807e-01	0.563
Impaired BRCA2 binding to SEM1 (DSS1)	R-HSA-9763198	2.732807e-01	0.563
Defective Mismatch Repair Associated With PMS2	R-HSA-5632987	2.732807e-01	0.563
Defective Mismatch Repair Associated With MLH1	R-HSA-5545483	2.732807e-01	0.563
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4	R-HSA-9632697	2.732807e-01	0.563
Impaired BRCA2 translocation to the nucleus	R-HSA-9709275	2.732807e-01	0.563
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function	R-HSA-9645722	2.732807e-01	0.563
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4	R-HSA-9630791	2.732807e-01	0.563
Activation and oligomerization of BAK protein	R-HSA-111452	2.732807e-01	0.563
Formation of editosomes by ADAR proteins	R-HSA-77042	2.732807e-01	0.563
Inhibition of PKR	R-HSA-169131	2.732807e-01	0.563
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	2.765981e-01	0.558
Glycogen storage diseases	R-HSA-3229121	2.765981e-01	0.558
SHC-mediated cascade:FGFR2	R-HSA-5654699	2.776487e-01	0.557
Interaction between L1 and Ankyrins	R-HSA-445095	2.776487e-01	0.557
Signaling by Insulin receptor	R-HSA-74752	2.807229e-01	0.552
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	2.887776e-01	0.539
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	2.887776e-01	0.539
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	2.887776e-01	0.539
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	2.887776e-01	0.539
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	2.887776e-01	0.539
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	2.887776e-01	0.539
FRS-mediated FGFR4 signaling	R-HSA-5654712	2.916590e-01	0.535
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	2.916590e-01	0.535
rRNA processing	R-HSA-72312	2.945466e-01	0.531
WNT mediated activation of DVL	R-HSA-201688	3.003684e-01	0.522
MAPK1 (ERK2) activation	R-HSA-112411	3.003684e-01	0.522
CASP8 activity is inhibited	R-HSA-5218900	3.003684e-01	0.522
Regulation of NPAS4 gene transcription	R-HSA-9768777	3.003684e-01	0.522
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	3.003684e-01	0.522
Unwinding of DNA	R-HSA-176974	3.003684e-01	0.522
Leishmania infection	R-HSA-9658195	3.010184e-01	0.521
Parasitic Infection Pathways	R-HSA-9824443	3.010184e-01	0.521
Phase 0 - rapid depolarisation	R-HSA-5576892	3.023334e-01	0.520
Degradation of CDH1	R-HSA-9766229	3.053893e-01	0.515
PKA activation in glucagon signalling	R-HSA-164378	3.070940e-01	0.513
PKA activation	R-HSA-163615	3.070940e-01	0.513
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	3.070940e-01	0.513
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	3.072666e-01	0.512
Activation of AKT2	R-HSA-165158	3.072666e-01	0.512
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	3.072666e-01	0.512
NTRK2 activates RAC1	R-HSA-9032759	3.072666e-01	0.512
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	3.072666e-01	0.512
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	3.072666e-01	0.512
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	3.072666e-01	0.512
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	3.072666e-01	0.512
Regulation of MITF-M dependent genes involved in invasion	R-HSA-9854909	3.072666e-01	0.512
NrCAM interactions	R-HSA-447038	3.072666e-01	0.512
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	3.072666e-01	0.512
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	3.085862e-01	0.511
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	3.092438e-01	0.510
DNA Damage Recognition in GG-NER	R-HSA-5696394	3.102358e-01	0.508
Activation of HOX genes during differentiation	R-HSA-5619507	3.108701e-01	0.507
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	3.108701e-01	0.507
Selenoamino acid metabolism	R-HSA-2408522	3.150044e-01	0.502
Transcriptional Regulation by E2F6	R-HSA-8953750	3.162645e-01	0.500
Sensory processing of sound	R-HSA-9659379	3.190147e-01	0.496
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	3.190760e-01	0.496
Growth hormone receptor signaling	R-HSA-982772	3.190760e-01	0.496
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	3.209626e-01	0.494
Removal of the Flap Intermediate	R-HSA-69166	3.242705e-01	0.489
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	3.242705e-01	0.489
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	3.242705e-01	0.489
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	3.242705e-01	0.489
DNA Replication	R-HSA-69306	3.261082e-01	0.487
Termination of translesion DNA synthesis	R-HSA-5656169	3.274410e-01	0.485
Platelet calcium homeostasis	R-HSA-418360	3.274410e-01	0.485
Regulation of CDH11 Expression and Function	R-HSA-9759475	3.274410e-01	0.485
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	3.276520e-01	0.485
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	3.319774e-01	0.479
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	3.335284e-01	0.477
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	3.358043e-01	0.474
Maturation of nucleoprotein	R-HSA-9694631	3.380335e-01	0.471
Diseases associated with the TLR signaling cascade	R-HSA-5602358	3.380818e-01	0.471
Diseases of Immune System	R-HSA-5260271	3.380818e-01	0.471
Binding and entry of HIV virion	R-HSA-173107	3.435602e-01	0.464
MAPK3 (ERK1) activation	R-HSA-110056	3.435602e-01	0.464
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	3.435602e-01	0.464
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	3.435602e-01	0.464
Folding of actin by CCT/TriC	R-HSA-390450	3.435602e-01	0.464
Regulation of the apoptosome activity	R-HSA-9627069	3.435602e-01	0.464
Formation of apoptosome	R-HSA-111458	3.435602e-01	0.464
PI3K/AKT activation	R-HSA-198203	3.435602e-01	0.464
Activation of NF-kappaB in B cells	R-HSA-1169091	3.442214e-01	0.463
TRAF6 mediated NF-kB activation	R-HSA-933542	3.468499e-01	0.460
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	3.528502e-01	0.452
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	3.528502e-01	0.452
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	3.600206e-01	0.444
Processive synthesis on the lagging strand	R-HSA-69183	3.600206e-01	0.444
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	3.600206e-01	0.444
Protein methylation	R-HSA-8876725	3.600206e-01	0.444
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	3.600206e-01	0.444
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	3.601343e-01	0.444
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	3.601343e-01	0.444
Potential therapeutics for SARS	R-HSA-9679191	3.609975e-01	0.442
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	3.639593e-01	0.439
Signalling to p38 via RIT and RIN	R-HSA-187706	3.649533e-01	0.438
PDE3B signalling	R-HSA-165160	3.649533e-01	0.438
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	3.649533e-01	0.438
PKB-mediated events	R-HSA-109703	3.649533e-01	0.438
PTK6 Regulates Cell Cycle	R-HSA-8849470	3.649533e-01	0.438
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	3.649533e-01	0.438
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	3.649533e-01	0.438
Release of apoptotic factors from the mitochondria	R-HSA-111457	3.649533e-01	0.438
Diseases of Base Excision Repair	R-HSA-9605308	3.649533e-01	0.438
Sodium-coupled phosphate cotransporters	R-HSA-427652	3.649533e-01	0.438
Protein folding	R-HSA-391251	3.666935e-01	0.436
Chaperonin-mediated protein folding	R-HSA-390466	3.668351e-01	0.436
VxPx cargo-targeting to cilium	R-HSA-5620916	3.691961e-01	0.433
Glycogen synthesis	R-HSA-3322077	3.691961e-01	0.433
FRS-mediated FGFR1 signaling	R-HSA-5654693	3.748237e-01	0.426
ATP-dependent chromatin remodelers	R-HSA-9932444	3.748237e-01	0.426
SWI/SNF chromatin remodelers	R-HSA-9932451	3.748237e-01	0.426
HDMs demethylate histones	R-HSA-3214842	3.748237e-01	0.426
Interleukin-7 signaling	R-HSA-1266695	3.748237e-01	0.426
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	3.784421e-01	0.422
Nef mediated downregulation of CD28 cell surface expression	R-HSA-164939	3.804968e-01	0.420
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects	R-HSA-9632693	3.804968e-01	0.420
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects	R-HSA-9630750	3.804968e-01	0.420
Signaling by extracellular domain mutants of KIT	R-HSA-9680187	3.804968e-01	0.420
Signaling by juxtamembrane domain KIT mutants	R-HSA-9669935	3.804968e-01	0.420
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	3.804968e-01	0.420
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	R-HSA-5603027	3.804968e-01	0.420
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9630794	3.804968e-01	0.420
Signaling by TCF7L2 mutants	R-HSA-5339700	3.804968e-01	0.420
Defective SLC12A3 causes Gitelman syndrome (GS)	R-HSA-5619087	3.804968e-01	0.420
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	R-HSA-5083628	3.804968e-01	0.420
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	3.804968e-01	0.420
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome	R-HSA-5678420	3.804968e-01	0.420
Signaling by kinase domain mutants of KIT	R-HSA-9669933	3.804968e-01	0.420
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	3.804968e-01	0.420
IKBKB deficiency causes SCID	R-HSA-5602636	3.804968e-01	0.420
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5660724	3.804968e-01	0.420
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5619081	3.804968e-01	0.420
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	3.804968e-01	0.420
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	3.804968e-01	0.420
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9632700	3.804968e-01	0.420
Transport of connexins along the secretory pathway	R-HSA-190827	3.804968e-01	0.420
Inhibition of membrane repair	R-HSA-9635644	3.804968e-01	0.420
Oligomerization of connexins into connexons	R-HSA-190704	3.804968e-01	0.420
NTRK3 as a dependence receptor	R-HSA-9603505	3.804968e-01	0.420
Vif-mediated degradation of APOBEC3G	R-HSA-180585	3.808094e-01	0.419
Translation of Structural Proteins	R-HSA-9694635	3.835256e-01	0.416
Regulation of mitotic cell cycle	R-HSA-453276	3.838624e-01	0.416
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	3.838624e-01	0.416
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	3.861866e-01	0.413
Bicarbonate transporters	R-HSA-425381	3.865135e-01	0.413
CD163 mediating an anti-inflammatory response	R-HSA-9662834	3.865135e-01	0.413
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	3.957147e-01	0.403
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	3.957147e-01	0.403
Phase 4 - resting membrane potential	R-HSA-5576886	3.957147e-01	0.403
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	3.957147e-01	0.403
WNT5A-dependent internalization of FZD4	R-HSA-5099900	3.957147e-01	0.403
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	3.957147e-01	0.403
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	3.957147e-01	0.403
MyD88 deficiency (TLR2/4)	R-HSA-5602498	4.003745e-01	0.398
PKA-mediated phosphorylation of CREB	R-HSA-111931	4.003745e-01	0.398
TRP channels	R-HSA-3295583	4.028474e-01	0.395
DNA strand elongation	R-HSA-69190	4.041019e-01	0.394
GPER1 signaling	R-HSA-9634597	4.043385e-01	0.393
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	4.046124e-01	0.393
Degradation of DVL	R-HSA-4641258	4.046124e-01	0.393
Innate Immune System	R-HSA-168249	4.106018e-01	0.387
Ca2+ pathway	R-HSA-4086398	4.189545e-01	0.378
PTK6 promotes HIF1A stabilization	R-HSA-8857538	4.207016e-01	0.376
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	4.207016e-01	0.376
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	4.207016e-01	0.376
NADPH regeneration	R-HSA-389542	4.207016e-01	0.376
Abacavir transmembrane transport	R-HSA-2161517	4.207016e-01	0.376
Neurofascin interactions	R-HSA-447043	4.207016e-01	0.376
DNA Damage Bypass	R-HSA-73893	4.254006e-01	0.371
PI3K events in ERBB4 signaling	R-HSA-1250342	4.287614e-01	0.368
Sensing of DNA Double Strand Breaks	R-HSA-5693548	4.287614e-01	0.368
Integration of provirus	R-HSA-162592	4.287614e-01	0.368
Reduction of cytosolic Ca++ levels	R-HSA-418359	4.287614e-01	0.368
Nuclear RNA decay	R-HSA-9930044	4.297200e-01	0.367
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	4.297200e-01	0.367
Cardiogenesis	R-HSA-9733709	4.297200e-01	0.367
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	4.297200e-01	0.367
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	4.307798e-01	0.366
EPHA-mediated growth cone collapse	R-HSA-3928663	4.307798e-01	0.366
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	4.310721e-01	0.365
Acetylcholine regulates insulin secretion	R-HSA-399997	4.310721e-01	0.365
TRAF3-dependent IRF activation pathway	R-HSA-918233	4.310721e-01	0.365
MHC class II antigen presentation	R-HSA-2132295	4.321268e-01	0.364
Signaling by PDGF	R-HSA-186797	4.412815e-01	0.355
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	4.434094e-01	0.353
PI3K Cascade	R-HSA-109704	4.464283e-01	0.350
Signaling by FGFR2 in disease	R-HSA-5655253	4.464283e-01	0.350
XBP1(S) activates chaperone genes	R-HSA-381038	4.485256e-01	0.348
Amine ligand-binding receptors	R-HSA-375280	4.491903e-01	0.348
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	4.521036e-01	0.345
Non-integrin membrane-ECM interactions	R-HSA-3000171	4.541154e-01	0.343
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	4.551930e-01	0.342
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	4.571297e-01	0.340
FRS-mediated FGFR2 signaling	R-HSA-5654700	4.584894e-01	0.339
Inflammasomes	R-HSA-622312	4.584894e-01	0.339
RAF-independent MAPK1/3 activation	R-HSA-112409	4.620292e-01	0.335
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	4.658460e-01	0.332
Regulation of NPAS4 gene expression	R-HSA-9768759	4.658460e-01	0.332
Elevation of cytosolic Ca2+ levels	R-HSA-139853	4.658460e-01	0.332
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	4.658460e-01	0.332
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	4.658460e-01	0.332
Uptake and function of anthrax toxins	R-HSA-5210891	4.658460e-01	0.332
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	4.699206e-01	0.328
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	4.699206e-01	0.328
Regulation of IFNG signaling	R-HSA-877312	4.699206e-01	0.328
Interleukin-15 signaling	R-HSA-8983432	4.699206e-01	0.328
Fanconi Anemia Pathway	R-HSA-6783310	4.713095e-01	0.327
Asymmetric localization of PCP proteins	R-HSA-4608870	4.713095e-01	0.327
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	4.713095e-01	0.327
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	4.719000e-01	0.326
Defective PAPSS2 causes SEMD-PA	R-HSA-3560796	4.719000e-01	0.326
Interaction between PHLDA1 and AURKA	R-HSA-8854521	4.719000e-01	0.326
Signalling to ERK5	R-HSA-198765	4.719000e-01	0.326
Regulation of cortical dendrite branching	R-HSA-8985801	4.719000e-01	0.326
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	4.719000e-01	0.326
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	4.719000e-01	0.326
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	R-HSA-5083633	4.719000e-01	0.326
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	4.719000e-01	0.326
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	4.719000e-01	0.326
Defective SLC12A1 causes Bartter syndrome 1 (BS1)	R-HSA-5619104	4.719000e-01	0.326
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	4.719000e-01	0.326
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	R-HSA-5083629	4.719000e-01	0.326
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	4.719000e-01	0.326
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	4.719000e-01	0.326
mRNA Editing: A to I Conversion	R-HSA-75064	4.719000e-01	0.326
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis	R-HSA-9708296	4.719000e-01	0.326
Neurophilin interactions with VEGF and VEGFR	R-HSA-194306	4.719000e-01	0.326
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	4.719000e-01	0.326
Influenza Virus Induced Apoptosis	R-HSA-168277	4.719000e-01	0.326
Defective ABCC8 can cause hypo- and hyper-glycemias	R-HSA-5683177	4.719000e-01	0.326
C6 deamination of adenosine	R-HSA-75102	4.719000e-01	0.326
MET activates PI3K/AKT signaling	R-HSA-8851907	4.738280e-01	0.324
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	4.738280e-01	0.324
Activated NTRK2 signals through CDK5	R-HSA-9032845	4.738280e-01	0.324
Activated NTRK3 signals through PI3K	R-HSA-9603381	4.738280e-01	0.324
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	4.738280e-01	0.324
Formation of Incision Complex in GG-NER	R-HSA-5696395	4.756279e-01	0.323
Attenuation phase	R-HSA-3371568	4.756279e-01	0.323
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	4.756279e-01	0.323
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	4.756279e-01	0.323
Generation of second messenger molecules	R-HSA-202433	4.756279e-01	0.323
Glycogen metabolism	R-HSA-8982491	4.756279e-01	0.323
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	4.776024e-01	0.321
G alpha (q) signalling events	R-HSA-416476	4.799633e-01	0.319
Dual Incision in GG-NER	R-HSA-5696400	4.804240e-01	0.318
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	4.804240e-01	0.318
Adipogenesis	R-HSA-9843745	4.831630e-01	0.316
Formation of RNA Pol II elongation complex	R-HSA-112382	4.881539e-01	0.311
Orc1 removal from chromatin	R-HSA-68949	4.881539e-01	0.311
Syndecan interactions	R-HSA-3000170	4.921745e-01	0.308
mRNA Splicing - Minor Pathway	R-HSA-72165	4.932391e-01	0.307
Hedgehog 'on' state	R-HSA-5632684	4.934159e-01	0.307
Resolution of Abasic Sites (AP sites)	R-HSA-73933	4.989038e-01	0.302
GAB1 signalosome	R-HSA-180292	4.998244e-01	0.301
RNA Polymerase III Transcription Termination	R-HSA-73980	4.998244e-01	0.301
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	4.998244e-01	0.301
Synaptic adhesion-like molecules	R-HSA-8849932	4.998244e-01	0.301
Mismatch Repair	R-HSA-5358508	4.998244e-01	0.301
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	5.053240e-01	0.296
Regulation of Apoptosis	R-HSA-169911	5.053240e-01	0.296
RNA Polymerase II Transcription Elongation	R-HSA-75955	5.087457e-01	0.293
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	5.095208e-01	0.293
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	5.096854e-01	0.293
Interleukin-6 signaling	R-HSA-1059683	5.096854e-01	0.293
Maturation of nucleoprotein	R-HSA-9683610	5.096854e-01	0.293
Replication of the SARS-CoV-1 genome	R-HSA-9682706	5.096854e-01	0.293
Activation of the pre-replicative complex	R-HSA-68962	5.127684e-01	0.290
Downstream TCR signaling	R-HSA-202424	5.135588e-01	0.289
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	5.149198e-01	0.288
Protein-protein interactions at synapses	R-HSA-6794362	5.183922e-01	0.285
Deadenylation of mRNA	R-HSA-429947	5.216755e-01	0.283
Plasma lipoprotein assembly	R-HSA-8963898	5.216755e-01	0.283
Degradation of CRY and PER proteins	R-HSA-9932298	5.218624e-01	0.282
Translation of Structural Proteins	R-HSA-9683701	5.218624e-01	0.282
Activated NTRK2 signals through FYN	R-HSA-9032500	5.238929e-01	0.281
Regulation by c-FLIP	R-HSA-3371378	5.238929e-01	0.281
phospho-PLA2 pathway	R-HSA-111995	5.238929e-01	0.281
Dimerization of procaspase-8	R-HSA-69416	5.238929e-01	0.281
EGFR interacts with phospholipase C-gamma	R-HSA-212718	5.238929e-01	0.281
Activated NTRK2 signals through PI3K	R-HSA-9028335	5.238929e-01	0.281
FGFR1b ligand binding and activation	R-HSA-190370	5.238929e-01	0.281
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	5.238929e-01	0.281
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	5.238929e-01	0.281
Sodium/Proton exchangers	R-HSA-425986	5.238929e-01	0.281
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	5.298115e-01	0.276
PI-3K cascade:FGFR3	R-HSA-5654710	5.328287e-01	0.273
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	5.328287e-01	0.273
Specification of the neural plate border	R-HSA-9834899	5.328287e-01	0.273
Other interleukin signaling	R-HSA-449836	5.328287e-01	0.273
RNA Polymerase I Transcription Initiation	R-HSA-73762	5.444404e-01	0.264
Antigen processing-Cross presentation	R-HSA-1236975	5.446719e-01	0.264
IRE1alpha activates chaperones	R-HSA-381070	5.453985e-01	0.263
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	5.478208e-01	0.261
Signal regulatory protein family interactions	R-HSA-391160	5.478208e-01	0.261
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	5.478208e-01	0.261
G alpha (z) signalling events	R-HSA-418597	5.491456e-01	0.260
Activated NTRK3 signals through PLCG1	R-HSA-9034793	5.498218e-01	0.260
PLC-gamma1 signalling	R-HSA-167021	5.498218e-01	0.260
Signaling by plasma membrane FGFR1 fusions	R-HSA-8853336	5.498218e-01	0.260
MET activates PTPN11	R-HSA-8865999	5.498218e-01	0.260
Defective HPRT1 disrupts guanine and hypoxanthine salvage	R-HSA-9734281	5.498218e-01	0.260
Invadopodia formation	R-HSA-8941237	5.498218e-01	0.260
Adrenaline signalling through Alpha-2 adrenergic receptor	R-HSA-392023	5.498218e-01	0.260
Defective GCLC causes HAGGSD	R-HSA-5578999	5.498218e-01	0.260
IRAK4 deficiency (TLR5)	R-HSA-5603037	5.498218e-01	0.260
Defective ABCA1 causes TGD	R-HSA-5682113	5.498218e-01	0.260
STAT6-mediated induction of chemokines	R-HSA-3249367	5.498218e-01	0.260
Activation of BMF and translocation to mitochondria	R-HSA-139910	5.498218e-01	0.260
Intracellular oxygen transport	R-HSA-8981607	5.498218e-01	0.260
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	5.498218e-01	0.260
CASP5-mediated substrate cleavage	R-HSA-9960525	5.498218e-01	0.260
Histamine receptors	R-HSA-390650	5.498218e-01	0.260
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	5.498218e-01	0.260
CASP4-mediated substrate cleavage	R-HSA-9960519	5.498218e-01	0.260
Degradation of AXIN	R-HSA-4641257	5.538132e-01	0.257
PI-3K cascade:FGFR4	R-HSA-5654720	5.647126e-01	0.248
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	5.647126e-01	0.248
Protein hydroxylation	R-HSA-9629569	5.647126e-01	0.248
Inwardly rectifying K+ channels	R-HSA-1296065	5.648570e-01	0.248
Hh mutants abrogate ligand secretion	R-HSA-5387390	5.665805e-01	0.247
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	5.688671e-01	0.245
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	5.688671e-01	0.245
ARMS-mediated activation	R-HSA-170984	5.706431e-01	0.244
Interleukin-21 signaling	R-HSA-9020958	5.706431e-01	0.244
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	5.706431e-01	0.244
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	5.706431e-01	0.244
Regulation of signaling by NODAL	R-HSA-1433617	5.706431e-01	0.244
Lipophagy	R-HSA-9613354	5.706431e-01	0.244
mRNA Editing	R-HSA-75072	5.706431e-01	0.244
Regulation of CDH11 gene transcription	R-HSA-9762293	5.706431e-01	0.244
Regulated proteolysis of p75NTR	R-HSA-193692	5.706431e-01	0.244
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	5.706431e-01	0.244
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	5.706431e-01	0.244
Respiratory syncytial virus genome replication	R-HSA-9834752	5.706431e-01	0.244
Interleukin-1 processing	R-HSA-448706	5.706431e-01	0.244
MET promotes cell motility	R-HSA-8875878	5.772642e-01	0.239
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	5.782867e-01	0.238
rRNA modification in the nucleus and cytosol	R-HSA-6790901	5.793683e-01	0.237
UCH proteinases	R-HSA-5689603	5.811681e-01	0.236
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	5.841544e-01	0.233
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	5.841544e-01	0.233
Formation of the anterior neural plate	R-HSA-9823739	5.841544e-01	0.233
G-protein beta:gamma signalling	R-HSA-397795	5.898729e-01	0.229
Lagging Strand Synthesis	R-HSA-69186	5.953601e-01	0.225
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	5.953601e-01	0.225
Zygotic genome activation (ZGA)	R-HSA-9819196	5.953601e-01	0.225
ER-Phagosome pathway	R-HSA-1236974	5.988036e-01	0.223
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	6.001073e-01	0.222
Plasma lipoprotein clearance	R-HSA-8964043	6.001073e-01	0.222
Processive synthesis on the C-strand of the telomere	R-HSA-174414	6.052131e-01	0.218
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	6.052131e-01	0.218
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	6.052131e-01	0.218
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	6.063333e-01	0.217
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	6.071637e-01	0.217
Platelet homeostasis	R-HSA-418346	6.076477e-01	0.216
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	6.093484e-01	0.215
2-LTR circle formation	R-HSA-164843	6.139668e-01	0.212
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	6.139668e-01	0.212
Interleukin-27 signaling	R-HSA-9020956	6.139668e-01	0.212
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	6.139668e-01	0.212
Signaling by Leptin	R-HSA-2586552	6.139668e-01	0.212
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	6.141158e-01	0.212
Vpu mediated degradation of CD4	R-HSA-180534	6.141158e-01	0.212
MTF1 activates gene expression	R-HSA-5660489	6.162500e-01	0.210
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	6.162500e-01	0.210
Activated NTRK2 signals through PLCG1	R-HSA-9026527	6.162500e-01	0.210
ATP sensitive Potassium channels	R-HSA-1296025	6.162500e-01	0.210
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	6.162500e-01	0.210
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine	R-HSA-9735763	6.162500e-01	0.210
Nucleotide catabolism defects	R-HSA-9735786	6.162500e-01	0.210
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate	R-HSA-2978092	6.162500e-01	0.210
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	6.162500e-01	0.210
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	6.162500e-01	0.210
Electric Transmission Across Gap Junctions	R-HSA-112303	6.162500e-01	0.210
Transmission across Electrical Synapses	R-HSA-112307	6.162500e-01	0.210
MDK and PTN in ALK signaling	R-HSA-9851151	6.162500e-01	0.210
Activation of NOXA and translocation to mitochondria	R-HSA-111448	6.162500e-01	0.210
Sensory perception of sour taste	R-HSA-9729555	6.162500e-01	0.210
NADE modulates death signalling	R-HSA-205025	6.162500e-01	0.210
Regulation of HMOX1 expression and activity	R-HSA-9707587	6.162500e-01	0.210
Interleukin-38 signaling	R-HSA-9007892	6.162500e-01	0.210
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	6.185691e-01	0.209
Phosphorylation of the APC/C	R-HSA-176412	6.185691e-01	0.209
Defective GALNT3 causes HFTC	R-HSA-5083625	6.185691e-01	0.209
Defective GALNT12 causes CRCS1	R-HSA-5083636	6.185691e-01	0.209
Killing mechanisms	R-HSA-9664420	6.185691e-01	0.209
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	6.185691e-01	0.209
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	6.185691e-01	0.209
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	6.298916e-01	0.201
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	6.311258e-01	0.200
Formation of the Early Elongation Complex	R-HSA-113418	6.311258e-01	0.200
HIV elongation arrest and recovery	R-HSA-167287	6.311258e-01	0.200
Pausing and recovery of HIV elongation	R-HSA-167290	6.311258e-01	0.200
COPI-mediated anterograde transport	R-HSA-6807878	6.361092e-01	0.196
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	6.375343e-01	0.195
Switching of origins to a post-replicative state	R-HSA-69052	6.399259e-01	0.194
Integration of energy metabolism	R-HSA-163685	6.411126e-01	0.193
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	6.437826e-01	0.191
Hh mutants are degraded by ERAD	R-HSA-5362768	6.437826e-01	0.191
Transcriptional regulation of testis differentiation	R-HSA-9690406	6.509944e-01	0.186
Processing of Intronless Pre-mRNAs	R-HSA-77595	6.509944e-01	0.186
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	6.509944e-01	0.186
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	6.509944e-01	0.186
PI-3K cascade:FGFR1	R-HSA-5654689	6.526191e-01	0.185
FGFR2 alternative splicing	R-HSA-6803529	6.526191e-01	0.185
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	6.526191e-01	0.185
Regulation of IFNA/IFNB signaling	R-HSA-912694	6.526191e-01	0.185
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	6.538573e-01	0.185
RHOBTB3 ATPase cycle	R-HSA-9706019	6.538573e-01	0.185
Presynaptic depolarization and calcium channel opening	R-HSA-112308	6.538573e-01	0.185
Formation of the posterior neural plate	R-HSA-9832991	6.538573e-01	0.185
Ionotropic activity of kainate receptors	R-HSA-451306	6.538573e-01	0.185
vRNP Assembly	R-HSA-192905	6.538573e-01	0.185
Prostanoid ligand receptors	R-HSA-391908	6.538573e-01	0.185
RNA Polymerase II Pre-transcription Events	R-HSA-674695	6.561383e-01	0.183
Late SARS-CoV-2 Infection Events	R-HSA-9772573	6.586045e-01	0.181
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	6.600873e-01	0.180
Interferon alpha/beta signaling	R-HSA-909733	6.674793e-01	0.176
NOSIP mediated eNOS trafficking	R-HSA-203754	6.728793e-01	0.172
Defective SLC1A3 causes episodic ataxia 6 (EA6)	R-HSA-5619062	6.728793e-01	0.172
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	6.728793e-01	0.172
Post-transcriptional silencing by small RNAs	R-HSA-426496	6.728793e-01	0.172
Suppression of autophagy	R-HSA-9636569	6.728793e-01	0.172
Muscarinic acetylcholine receptors	R-HSA-390648	6.728793e-01	0.172
Nectin/Necl trans heterodimerization	R-HSA-420597	6.728793e-01	0.172
Reelin signalling pathway	R-HSA-8866376	6.728793e-01	0.172
Co-inhibition by BTLA	R-HSA-9927353	6.728793e-01	0.172
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	6.737485e-01	0.172
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	6.791276e-01	0.168
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	6.797213e-01	0.168
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	6.813998e-01	0.167
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	6.813998e-01	0.167
Replication of the SARS-CoV-2 genome	R-HSA-9694686	6.813998e-01	0.167
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	6.817436e-01	0.166
RNA Polymerase III Transcription	R-HSA-74158	6.817436e-01	0.166
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	6.845400e-01	0.165
Condensation of Prometaphase Chromosomes	R-HSA-2514853	6.903843e-01	0.161
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	6.903843e-01	0.161
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	6.903843e-01	0.161
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	6.903843e-01	0.161
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	6.903843e-01	0.161
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	6.948739e-01	0.158
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	7.022687e-01	0.153
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	7.041887e-01	0.152
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	7.041887e-01	0.152
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	7.097874e-01	0.149
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	7.097874e-01	0.149
Plus-strand DNA synthesis	R-HSA-164525	7.211547e-01	0.142
Nef Mediated CD8 Down-regulation	R-HSA-182218	7.211547e-01	0.142
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	7.211547e-01	0.142
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	7.211547e-01	0.142
Signaling by MAPK mutants	R-HSA-9652817	7.211547e-01	0.142
Phase 1 - inactivation of fast Na+ channels	R-HSA-5576894	7.211547e-01	0.142
Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS)	R-HSA-5619063	7.211547e-01	0.142
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	7.211547e-01	0.142
Noncanonical activation of NOTCH3	R-HSA-9017802	7.211547e-01	0.142
Synthesis of PS	R-HSA-1483101	7.211547e-01	0.142
Phosphorylation of Emi1	R-HSA-176417	7.211547e-01	0.142
Formation of the Editosome	R-HSA-75094	7.211547e-01	0.142
VEGF binds to VEGFR leading to receptor dimerization	R-HSA-195399	7.211547e-01	0.142
CLEC7A/inflammasome pathway	R-HSA-5660668	7.211547e-01	0.142
VEGF ligand-receptor interactions	R-HSA-194313	7.211547e-01	0.142
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	7.211547e-01	0.142
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	7.211547e-01	0.142
TRAIL signaling	R-HSA-75158	7.211547e-01	0.142
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	7.211547e-01	0.142
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	7.211547e-01	0.142
Hedgehog ligand biogenesis	R-HSA-5358346	7.230261e-01	0.141
Polymerase switching	R-HSA-69091	7.236718e-01	0.140
Leading Strand Synthesis	R-HSA-69109	7.236718e-01	0.140
Scavenging by Class F Receptors	R-HSA-3000484	7.236718e-01	0.140
Interleukin-35 Signalling	R-HSA-8984722	7.236718e-01	0.140
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	7.236718e-01	0.140
OAS antiviral response	R-HSA-8983711	7.236718e-01	0.140
Gastrulation	R-HSA-9758941	7.237026e-01	0.140
PI-3K cascade:FGFR2	R-HSA-5654695	7.277995e-01	0.138
Activation of G protein gated Potassium channels	R-HSA-1296041	7.277995e-01	0.138
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	7.277995e-01	0.138
G protein gated Potassium channels	R-HSA-1296059	7.277995e-01	0.138
Acyl chain remodelling of PS	R-HSA-1482801	7.277995e-01	0.138
Formation of the nephric duct	R-HSA-9830364	7.277995e-01	0.138
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	7.308143e-01	0.136
Disease	R-HSA-1643685	7.310512e-01	0.136
Pre-NOTCH Processing in Golgi	R-HSA-1912420	7.361862e-01	0.133
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	7.361862e-01	0.133
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	7.396142e-01	0.131
Neurexins and neuroligins	R-HSA-6794361	7.396142e-01	0.131
Uptake and actions of bacterial toxins	R-HSA-5339562	7.396142e-01	0.131
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	7.398278e-01	0.131
Defective CFTR causes cystic fibrosis	R-HSA-5678895	7.398278e-01	0.131
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	7.411528e-01	0.130
Platelet degranulation	R-HSA-114608	7.415266e-01	0.130
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	7.499721e-01	0.125
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	7.499721e-01	0.125
FGFR1c ligand binding and activation	R-HSA-190373	7.538803e-01	0.123
Diseases of nucleotide metabolism	R-HSA-9735804	7.538803e-01	0.123
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	7.538803e-01	0.123
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	7.538803e-01	0.123
Developmental Cell Lineages	R-HSA-9734767	7.543394e-01	0.122
Amino acids regulate mTORC1	R-HSA-9639288	7.555039e-01	0.122
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	7.555039e-01	0.122
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	7.566607e-01	0.121
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	7.590820e-01	0.120
HIV Transcription Elongation	R-HSA-167169	7.590820e-01	0.120
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	7.590820e-01	0.120
Regulation of PD-L1(CD274) translation	R-HSA-9909620	7.606465e-01	0.119
Formation of ATP by chemiosmotic coupling	R-HSA-163210	7.606465e-01	0.119
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	7.606465e-01	0.119
Common Pathway of Fibrin Clot Formation	R-HSA-140875	7.606465e-01	0.119
STAT5 Activation	R-HSA-9645135	7.623081e-01	0.118
Erythropoietin activates STAT5	R-HSA-9027283	7.623081e-01	0.118
Autointegration results in viral DNA circles	R-HSA-177539	7.623081e-01	0.118
Uncoating of the HIV Virion	R-HSA-162585	7.623081e-01	0.118
H139Hfs13* PPM1K causes a mild variant of MSUD	R-HSA-9912529	7.623081e-01	0.118
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	7.623081e-01	0.118
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	7.623081e-01	0.118
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	7.623081e-01	0.118
Integration of viral DNA into host genomic DNA	R-HSA-175567	7.623081e-01	0.118
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	7.634011e-01	0.117
Glucagon signaling in metabolic regulation	R-HSA-163359	7.634011e-01	0.117
SLC transporter disorders	R-HSA-5619102	7.678760e-01	0.115
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	7.695695e-01	0.114
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	7.695695e-01	0.114
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	7.706953e-01	0.113
RNA Polymerase I Transcription Termination	R-HSA-73863	7.707308e-01	0.113
Signaling by BMP	R-HSA-201451	7.707308e-01	0.113
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	7.707308e-01	0.113
ER Quality Control Compartment (ERQC)	R-HSA-901032	7.707308e-01	0.113
Insulin processing	R-HSA-264876	7.707308e-01	0.113
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	7.726955e-01	0.112
Maturation of spike protein	R-HSA-9694548	7.760808e-01	0.110
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	7.811934e-01	0.107
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	7.811934e-01	0.107
cGMP effects	R-HSA-418457	7.811934e-01	0.107
Physiological factors	R-HSA-5578768	7.811934e-01	0.107
Malate-aspartate shuttle	R-HSA-9856872	7.811934e-01	0.107
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	7.815084e-01	0.107
Signal amplification	R-HSA-392518	7.815084e-01	0.107
Calnexin/calreticulin cycle	R-HSA-901042	7.815084e-01	0.107
G-protein activation	R-HSA-202040	7.832349e-01	0.106
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	7.832349e-01	0.106
Basigin interactions	R-HSA-210991	7.832349e-01	0.106
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	7.835004e-01	0.106
NCAM signaling for neurite out-growth	R-HSA-375165	7.835004e-01	0.106
Synthesis of DNA	R-HSA-69239	7.856573e-01	0.105
Intraflagellar transport	R-HSA-5620924	7.879391e-01	0.104
NGF-stimulated transcription	R-HSA-9031628	7.879391e-01	0.104
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	7.921615e-01	0.101
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	7.921615e-01	0.101
Intra-Golgi traffic	R-HSA-6811438	7.921615e-01	0.101
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	7.943424e-01	0.100
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	7.973899e-01	0.098
NOSTRIN mediated eNOS trafficking	R-HSA-203641	7.973899e-01	0.098
Netrin mediated repulsion signals	R-HSA-418886	7.973899e-01	0.098
TRIF-mediated programmed cell death	R-HSA-2562578	7.973899e-01	0.098
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	7.973899e-01	0.098
DAG1 core M1 glycosylations	R-HSA-8932506	7.973899e-01	0.098
PTK6 Expression	R-HSA-8849473	7.973899e-01	0.098
mRNA Editing: C to U Conversion	R-HSA-72200	7.973899e-01	0.098
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	7.973899e-01	0.098
Nef Mediated CD4 Down-regulation	R-HSA-167590	7.973899e-01	0.098
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	7.973899e-01	0.098
Activation of PUMA and translocation to mitochondria	R-HSA-139915	7.973899e-01	0.098
VLDL clearance	R-HSA-8964046	7.973899e-01	0.098
Ca2+ activated K+ channels	R-HSA-1296052	7.973899e-01	0.098
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	8.024021e-01	0.096
Mitochondrial calcium ion transport	R-HSA-8949215	8.040302e-01	0.095
Ribavirin ADME	R-HSA-9755088	8.040302e-01	0.095
Adenylate cyclase inhibitory pathway	R-HSA-170670	8.058077e-01	0.094
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	8.058077e-01	0.094
Telomere C-strand synthesis initiation	R-HSA-174430	8.058077e-01	0.094
Lysosphingolipid and LPA receptors	R-HSA-419408	8.058077e-01	0.094
TP53 Regulates Metabolic Genes	R-HSA-5628897	8.064491e-01	0.093
Activation of GABAB receptors	R-HSA-991365	8.073414e-01	0.093
GABA B receptor activation	R-HSA-977444	8.073414e-01	0.093
Triglyceride catabolism	R-HSA-163560	8.144801e-01	0.089
G1/S-Specific Transcription	R-HSA-69205	8.144801e-01	0.089
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	8.231201e-01	0.085
LDL clearance	R-HSA-8964038	8.231201e-01	0.085
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	8.231201e-01	0.085
Dual incision in TC-NER	R-HSA-6782135	8.245974e-01	0.084
Regulation of insulin secretion	R-HSA-422356	8.248969e-01	0.084
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.249122e-01	0.084
Reverse Transcription of HIV RNA	R-HSA-162589	8.272955e-01	0.082
Minus-strand DNA synthesis	R-HSA-164516	8.272955e-01	0.082
DAG1 core M2 glycosylations	R-HSA-8932504	8.272955e-01	0.082
Regulation of NPAS4 mRNA translation	R-HSA-9768778	8.272955e-01	0.082
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	8.272955e-01	0.082
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	8.272955e-01	0.082
Co-stimulation by ICOS	R-HSA-9927354	8.272955e-01	0.082
Fructose biosynthesis	R-HSA-5652227	8.272955e-01	0.082
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	8.272955e-01	0.082
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	8.272955e-01	0.082
TGFBR3 PTM regulation	R-HSA-9839383	8.272955e-01	0.082
Nucleotide salvage defects	R-HSA-9734207	8.272955e-01	0.082
Alpha-defensins	R-HSA-1462054	8.272955e-01	0.082
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	8.272955e-01	0.082
ER to Golgi Anterograde Transport	R-HSA-199977	8.275813e-01	0.082
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	8.279246e-01	0.082
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	8.279246e-01	0.082
Nucleotide Excision Repair	R-HSA-5696398	8.336739e-01	0.079
Deadenylation-dependent mRNA decay	R-HSA-429914	8.364110e-01	0.078
Cargo concentration in the ER	R-HSA-5694530	8.404381e-01	0.075
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.404381e-01	0.075
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	8.405980e-01	0.075
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	8.405980e-01	0.075
Termination of O-glycan biosynthesis	R-HSA-977068	8.405980e-01	0.075
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	8.405980e-01	0.075
Infectious disease	R-HSA-5663205	8.430146e-01	0.074
Class I MHC mediated antigen processing & presentation	R-HSA-983169	8.430452e-01	0.074
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	8.477029e-01	0.072
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	8.477451e-01	0.072
Phase 2 - plateau phase	R-HSA-5576893	8.477451e-01	0.072
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	8.477451e-01	0.072
Synthesis of PG	R-HSA-1483148	8.477451e-01	0.072
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	8.492252e-01	0.071
MASTL Facilitates Mitotic Progression	R-HSA-2465910	8.527885e-01	0.069
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	8.527885e-01	0.069
5-Phosphoribose 1-diphosphate biosynthesis	R-HSA-73843	8.527885e-01	0.069
Butyrophilin (BTN) family interactions	R-HSA-8851680	8.527885e-01	0.069
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	8.563203e-01	0.067
Interleukin-6 family signaling	R-HSA-6783589	8.565603e-01	0.067
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	8.565603e-01	0.067
Cytoprotection by HMOX1	R-HSA-9707564	8.571954e-01	0.067
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	8.595209e-01	0.066
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	8.595209e-01	0.066
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	8.595209e-01	0.066
Unfolded Protein Response (UPR)	R-HSA-381119	8.633237e-01	0.064
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	8.654651e-01	0.063
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	8.654651e-01	0.063
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	8.654651e-01	0.063
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	8.654651e-01	0.063
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	8.705714e-01	0.060
GPCR downstream signalling	R-HSA-388396	8.710647e-01	0.060
MicroRNA (miRNA) biogenesis	R-HSA-203927	8.711049e-01	0.060
Polymerase switching on the C-strand of the telomere	R-HSA-174411	8.711049e-01	0.060
Glycogen breakdown (glycogenolysis)	R-HSA-70221	8.711049e-01	0.060
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	8.711049e-01	0.060
DNA replication initiation	R-HSA-68952	8.745197e-01	0.058
TET1,2,3 and TDG demethylate DNA	R-HSA-5221030	8.745197e-01	0.058
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	8.745197e-01	0.058
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	8.745197e-01	0.058
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	8.745197e-01	0.058
Formation of intermediate mesoderm	R-HSA-9761174	8.745197e-01	0.058
Maturation of spike protein	R-HSA-9683686	8.745197e-01	0.058
Metal sequestration by antimicrobial proteins	R-HSA-6799990	8.745197e-01	0.058
Tandem pore domain potassium channels	R-HSA-1296346	8.745197e-01	0.058
Integrin cell surface interactions	R-HSA-216083	8.776077e-01	0.057
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	8.802156e-01	0.055
Miscellaneous transport and binding events	R-HSA-5223345	8.802156e-01	0.055
FGFR1 ligand binding and activation	R-HSA-190242	8.812728e-01	0.055
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	8.812728e-01	0.055
Nephron development	R-HSA-9831926	8.812728e-01	0.055
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	8.843290e-01	0.053
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	8.843290e-01	0.053
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	8.870095e-01	0.052
Regulation of TLR by endogenous ligand	R-HSA-5686938	8.914124e-01	0.050
DAG1 core M3 glycosylations	R-HSA-8932505	8.930440e-01	0.049
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	8.930440e-01	0.049
FGFR2b ligand binding and activation	R-HSA-190377	8.930440e-01	0.049
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	8.930440e-01	0.049
Synthesis of PI	R-HSA-1483226	8.930440e-01	0.049
Cholesterol biosynthesis via desmosterol	R-HSA-6807047	8.930440e-01	0.049
Synthesis of PIPs at the ER membrane	R-HSA-1483248	8.930440e-01	0.049
LGI-ADAM interactions	R-HSA-5682910	8.930440e-01	0.049
SARS-CoV-2 modulates autophagy	R-HSA-9754560	8.930440e-01	0.049
Dissolution of Fibrin Clot	R-HSA-75205	8.930440e-01	0.049
Cellular response to hypoxia	R-HSA-1234174	8.946159e-01	0.048
Signaling by FGFR2 IIIa TM	R-HSA-8851708	8.953464e-01	0.048
E2F mediated regulation of DNA replication	R-HSA-113510	8.953464e-01	0.048
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	8.953464e-01	0.048
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	8.953464e-01	0.048
O2/CO2 exchange in erythrocytes	R-HSA-1480926	8.953464e-01	0.048
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	R-HSA-83936	8.963282e-01	0.048
Maturation of hRSV A proteins	R-HSA-9828806	8.963282e-01	0.048
Disorders of transmembrane transporters	R-HSA-5619115	8.979401e-01	0.047
Azathioprine ADME	R-HSA-9748787	8.994448e-01	0.046
FCERI mediated NF-kB activation	R-HSA-2871837	8.995700e-01	0.046
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.005389e-01	0.045
Pyrimidine salvage	R-HSA-73614	9.071953e-01	0.042
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.077552e-01	0.042
The phototransduction cascade	R-HSA-2514856	9.077552e-01	0.042
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.078533e-01	0.042
Eicosanoid ligand-binding receptors	R-HSA-391903	9.078533e-01	0.042
Extension of Telomeres	R-HSA-180786	9.083203e-01	0.042
Peroxisomal protein import	R-HSA-9033241	9.083203e-01	0.042
Triglyceride metabolism	R-HSA-8979227	9.083203e-01	0.042
Synthesis of diphthamide-EEF2	R-HSA-5358493	9.088346e-01	0.042
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	9.088346e-01	0.042
Signaling by activated point mutants of FGFR1	R-HSA-1839122	9.088346e-01	0.042
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	9.088346e-01	0.042
FMO oxidises nucleophiles	R-HSA-217271	9.088346e-01	0.042
Sodium/Calcium exchangers	R-HSA-425561	9.088346e-01	0.042
Proton-coupled monocarboxylate transport	R-HSA-433692	9.088346e-01	0.042
Protein localization	R-HSA-9609507	9.088903e-01	0.041
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.097763e-01	0.041
Transcription of the HIV genome	R-HSA-167172	9.164994e-01	0.038
RMTs methylate histone arginines	R-HSA-3214858	9.165990e-01	0.038
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.168333e-01	0.038
mRNA Capping	R-HSA-72086	9.170193e-01	0.038
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.170193e-01	0.038
Potassium Channels	R-HSA-1296071	9.187280e-01	0.037
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.189494e-01	0.037
Voltage gated Potassium channels	R-HSA-1296072	9.196723e-01	0.036
TRAF6 mediated IRF7 activation	R-HSA-933541	9.196723e-01	0.036
Serotonin clearance from the synaptic cleft	R-HSA-380615	9.222946e-01	0.035
Trafficking and processing of endosomal TLR	R-HSA-1679131	9.222946e-01	0.035
Maple Syrup Urine Disease	R-HSA-9865114	9.222946e-01	0.035
Estrogen biosynthesis	R-HSA-193144	9.222946e-01	0.035
Formation of paraxial mesoderm	R-HSA-9793380	9.223260e-01	0.035
tRNA processing	R-HSA-72306	9.248214e-01	0.034
RNA Polymerase III Transcription Initiation	R-HSA-76046	9.258854e-01	0.033
Mitochondrial protein import	R-HSA-1268020	9.286037e-01	0.032
G alpha (s) signalling events	R-HSA-418555	9.287033e-01	0.032
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	9.287785e-01	0.032
COPII-mediated vesicle transport	R-HSA-204005	9.288182e-01	0.032
ABC transporter disorders	R-HSA-5619084	9.296029e-01	0.032
Regulation of pyruvate metabolism	R-HSA-9861718	9.310307e-01	0.031
Adenylate cyclase activating pathway	R-HSA-170660	9.337680e-01	0.030
FGFR2c ligand binding and activation	R-HSA-190375	9.337680e-01	0.030
IL-6-type cytokine receptor ligand interactions	R-HSA-6788467	9.337680e-01	0.030
FGFR4 ligand binding and activation	R-HSA-190322	9.337680e-01	0.030
Signaling by activated point mutants of FGFR3	R-HSA-1839130	9.337680e-01	0.030
Mtb iron assimilation by chelation	R-HSA-1222449	9.337680e-01	0.030
Platelet Adhesion to exposed collagen	R-HSA-75892	9.337680e-01	0.030
FGFR3 mutant receptor activation	R-HSA-2033514	9.337680e-01	0.030
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	9.337680e-01	0.030
Interferon gamma signaling	R-HSA-877300	9.342982e-01	0.030
Pentose phosphate pathway	R-HSA-71336	9.346542e-01	0.029
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	9.357741e-01	0.029
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	9.374728e-01	0.028
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	9.374728e-01	0.028
Fructose metabolism	R-HSA-5652084	9.374728e-01	0.028
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.374728e-01	0.028
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	9.374728e-01	0.028
trans-Golgi Network Vesicle Budding	R-HSA-199992	9.395256e-01	0.027
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	9.411521e-01	0.026
Retrograde neurotrophin signalling	R-HSA-177504	9.435479e-01	0.025
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	9.435479e-01	0.025
FGFR3c ligand binding and activation	R-HSA-190372	9.435479e-01	0.025
Hydrolysis of LPC	R-HSA-1483115	9.435479e-01	0.025
Non-canonical inflammasome activation	R-HSA-9686114	9.435479e-01	0.025
Ciprofloxacin ADME	R-HSA-9793528	9.435479e-01	0.025
Acyl chain remodeling of CL	R-HSA-1482798	9.435479e-01	0.025
P2Y receptors	R-HSA-417957	9.435479e-01	0.025
Interleukin-20 family signaling	R-HSA-8854691	9.451530e-01	0.024
Free fatty acids regulate insulin secretion	R-HSA-400451	9.451530e-01	0.024
Carnitine shuttle	R-HSA-200425	9.451530e-01	0.024
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	9.451530e-01	0.024
Dectin-2 family	R-HSA-5621480	9.461397e-01	0.024
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	9.518842e-01	0.021
G beta:gamma signalling through BTK	R-HSA-8964315	9.518842e-01	0.021
RNA Polymerase III Chain Elongation	R-HSA-73780	9.518842e-01	0.021
Protein lipoylation	R-HSA-9857492	9.518842e-01	0.021
Transport and metabolism of PAPS	R-HSA-174362	9.518842e-01	0.021
FGFR3 ligand binding and activation	R-HSA-190239	9.518842e-01	0.021
Dopamine clearance from the synaptic cleft	R-HSA-379401	9.518842e-01	0.021
Other semaphorin interactions	R-HSA-416700	9.518842e-01	0.021
Thromboxane signalling through TP receptor	R-HSA-428930	9.519290e-01	0.021
Complex III assembly	R-HSA-9865881	9.519290e-01	0.021
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	9.524113e-01	0.021
HIV Transcription Initiation	R-HSA-167161	9.524113e-01	0.021
RNA Polymerase II Transcription Initiation	R-HSA-75953	9.524113e-01	0.021
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.524113e-01	0.021
Neurotransmitter release cycle	R-HSA-112310	9.527380e-01	0.021
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.531413e-01	0.021
Formation of the cornified envelope	R-HSA-6809371	9.534702e-01	0.021
Cytosolic tRNA aminoacylation	R-HSA-379716	9.572643e-01	0.019
Hyaluronan degradation	R-HSA-2160916	9.579003e-01	0.019
eNOS activation	R-HSA-203615	9.585032e-01	0.018
Hyaluronan metabolism	R-HSA-2142845	9.585032e-01	0.018
Class I peroxisomal membrane protein import	R-HSA-9603798	9.589898e-01	0.018
Activation of SMO	R-HSA-5635838	9.589898e-01	0.018
Fructose catabolism	R-HSA-70350	9.589898e-01	0.018
Attachment and Entry	R-HSA-9678110	9.589898e-01	0.018
Atorvastatin ADME	R-HSA-9754706	9.589898e-01	0.018
GABA receptor activation	R-HSA-977443	9.593411e-01	0.018
RNA Polymerase II Promoter Escape	R-HSA-73776	9.616563e-01	0.017
Nucleotide salvage	R-HSA-8956321	9.630401e-01	0.016
Aquaporin-mediated transport	R-HSA-445717	9.630401e-01	0.016
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.631568e-01	0.016
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.631568e-01	0.016
Abacavir ADME	R-HSA-2161522	9.631568e-01	0.016
G beta:gamma signalling through CDC42	R-HSA-8964616	9.650465e-01	0.015
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	9.650465e-01	0.015
Glycine degradation	R-HSA-6783984	9.650465e-01	0.015
Biosynthesis of maresin-like SPMs	R-HSA-9027307	9.650465e-01	0.015
Heme assimilation	R-HSA-9927020	9.650465e-01	0.015
Vitamin B6 activation to pyridoxal phosphate	R-HSA-964975	9.650465e-01	0.015
Galactose catabolism	R-HSA-70370	9.650465e-01	0.015
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	9.650465e-01	0.015
Response to metal ions	R-HSA-5660526	9.650465e-01	0.015
tRNA modification in the mitochondrion	R-HSA-6787450	9.650465e-01	0.015
Surfactant metabolism	R-HSA-5683826	9.656262e-01	0.015
Glycosphingolipid transport	R-HSA-9845576	9.673011e-01	0.014
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.673011e-01	0.014
Neddylation	R-HSA-8951664	9.677266e-01	0.014
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.677793e-01	0.014
Triglyceride biosynthesis	R-HSA-75109	9.677793e-01	0.014
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.678122e-01	0.014
Metabolism of cofactors	R-HSA-8978934	9.678122e-01	0.014
Mitochondrial protein degradation	R-HSA-9837999	9.682955e-01	0.014
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.692107e-01	0.014
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	9.702090e-01	0.013
SLC-mediated transport of organic cations	R-HSA-549127	9.710087e-01	0.013
Telomere Extension By Telomerase	R-HSA-171319	9.718404e-01	0.012
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.718404e-01	0.012
Signaling by GPCR	R-HSA-372790	9.722147e-01	0.012
CD22 mediated BCR regulation	R-HSA-5690714	9.723687e-01	0.012
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.743156e-01	0.011
Purine salvage	R-HSA-74217	9.743156e-01	0.011
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	9.746092e-01	0.011
Activated point mutants of FGFR2	R-HSA-2033519	9.746092e-01	0.011
Vitamin D (calciferol) metabolism	R-HSA-196791	9.746092e-01	0.011
Nucleotide-like (purinergic) receptors	R-HSA-418038	9.746092e-01	0.011
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.746499e-01	0.011
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.766601e-01	0.010
RSV-host interactions	R-HSA-9833110	9.768665e-01	0.010
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.772621e-01	0.010
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.772621e-01	0.010
Iron uptake and transport	R-HSA-917937	9.778583e-01	0.010
Gluconeogenesis	R-HSA-70263	9.779773e-01	0.010
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	9.783597e-01	0.010
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.783977e-01	0.009
Neurotransmitter clearance	R-HSA-112311	9.785313e-01	0.009
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.785313e-01	0.009
Post-translational protein phosphorylation	R-HSA-8957275	9.790787e-01	0.009
PPARA activates gene expression	R-HSA-1989781	9.793325e-01	0.009
Kidney development	R-HSA-9830369	9.794812e-01	0.009
Molecules associated with elastic fibres	R-HSA-2129379	9.812709e-01	0.008
Acyl chain remodelling of PI	R-HSA-1482922	9.815564e-01	0.008
Pregnenolone biosynthesis	R-HSA-196108	9.815564e-01	0.008
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.820058e-01	0.008
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.822173e-01	0.008
ABC-family proteins mediated transport	R-HSA-382556	9.823603e-01	0.008
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.834831e-01	0.007
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.836697e-01	0.007
FGFR2 ligand binding and activation	R-HSA-190241	9.842811e-01	0.007
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	9.842811e-01	0.007
Matriglycan biosynthesis on DAG1	R-HSA-9939291	9.842811e-01	0.007
Acyl chain remodelling of PG	R-HSA-1482925	9.842811e-01	0.007
Role of phospholipids in phagocytosis	R-HSA-2029485	9.843786e-01	0.007
Phospholipid metabolism	R-HSA-1483257	9.859517e-01	0.006
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.861294e-01	0.006
Serine metabolism	R-HSA-977347	9.866034e-01	0.006
Glutathione synthesis and recycling	R-HSA-174403	9.866034e-01	0.006
Attachment and Entry	R-HSA-9694614	9.866034e-01	0.006
Golgi Associated Vesicle Biogenesis	R-HSA-432722	9.875815e-01	0.005
Acyl chain remodelling of PC	R-HSA-1482788	9.876041e-01	0.005
Heme degradation	R-HSA-189483	9.876041e-01	0.005
Translation	R-HSA-72766	9.885318e-01	0.005
Neurotoxicity of clostridium toxins	R-HSA-168799	9.885827e-01	0.005
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.885827e-01	0.005
Ethanol oxidation	R-HSA-71384	9.885827e-01	0.005
Proteasome assembly	R-HSA-9907900	9.892077e-01	0.005
Regulation of PTEN mRNA translation	R-HSA-8943723	9.902696e-01	0.004
Biosynthesis of maresins	R-HSA-9018682	9.902696e-01	0.004
Formation of the ureteric bud	R-HSA-9830674	9.902696e-01	0.004
Mitochondrial mRNA modification	R-HSA-9937008	9.902696e-01	0.004
Somitogenesis	R-HSA-9824272	9.904886e-01	0.004
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.905988e-01	0.004
Leishmania parasite growth and survival	R-HSA-9664433	9.905988e-01	0.004
Acyl chain remodelling of PE	R-HSA-1482839	9.906086e-01	0.004
PERK regulates gene expression	R-HSA-381042	9.906086e-01	0.004
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.912621e-01	0.004
CYP2E1 reactions	R-HSA-211999	9.917074e-01	0.004
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.917074e-01	0.004
Mitochondrial RNA degradation	R-HSA-9836573	9.917074e-01	0.004
TNFs bind their physiological receptors	R-HSA-5669034	9.917074e-01	0.004
FGFR2 mutant receptor activation	R-HSA-1839126	9.918310e-01	0.004
Lysosome Vesicle Biogenesis	R-HSA-432720	9.918310e-01	0.004
Synthesis of PA	R-HSA-1483166	9.922375e-01	0.003
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.929328e-01	0.003
Laminin interactions	R-HSA-3000157	9.929328e-01	0.003
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.931509e-01	0.003
Metal ion SLC transporters	R-HSA-425410	9.935107e-01	0.003
Transport to the Golgi and subsequent modification	R-HSA-948021	9.935464e-01	0.003
Elastic fibre formation	R-HSA-1566948	9.938270e-01	0.003
MET activates PTK2 signaling	R-HSA-8874081	9.939772e-01	0.003
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	9.939772e-01	0.003
tRNA Aminoacylation	R-HSA-379724	9.945760e-01	0.002
Cell surface interactions at the vascular wall	R-HSA-202733	9.952973e-01	0.002
Insulin receptor recycling	R-HSA-77387	9.956259e-01	0.002
Prednisone ADME	R-HSA-9757110	9.956259e-01	0.002
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.956259e-01	0.002
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.956509e-01	0.002
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.958419e-01	0.002
Diseases of carbohydrate metabolism	R-HSA-5663084	9.961228e-01	0.002
Thyroxine biosynthesis	R-HSA-209968	9.962724e-01	0.002
Glucagon-type ligand receptors	R-HSA-420092	9.962724e-01	0.002
G alpha (i) signalling events	R-HSA-418594	9.962819e-01	0.002
Heme biosynthesis	R-HSA-189451	9.964911e-01	0.002
Nucleotide biosynthesis	R-HSA-8956320	9.966029e-01	0.001
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	9.972930e-01	0.001
Collagen formation	R-HSA-1474290	9.973621e-01	0.001
Paracetamol ADME	R-HSA-9753281	9.973861e-01	0.001
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.973885e-01	0.001
DAG1 glycosylations	R-HSA-8931838	9.976932e-01	0.001
Pyruvate metabolism	R-HSA-70268	9.978151e-01	0.001
Interleukin-10 signaling	R-HSA-6783783	9.978328e-01	0.001
Defective B3GALTL causes PpS	R-HSA-5083635	9.980342e-01	0.001
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.980736e-01	0.001
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.983248e-01	0.001
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.984106e-01	0.001
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.984600e-01	0.001
Synthesis of PC	R-HSA-1483191	9.985111e-01	0.001
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.985725e-01	0.001
Phosphate bond hydrolysis by NUDT proteins	R-HSA-2393930	9.985725e-01	0.001
ECM proteoglycans	R-HSA-3000178	9.985976e-01	0.001
Transferrin endocytosis and recycling	R-HSA-917977	9.987836e-01	0.001
Metabolism of ingested SeMet, Sec, MeSec into H2Se	R-HSA-2408508	9.987836e-01	0.001
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.988837e-01	0.000
Chemokine receptors bind chemokines	R-HSA-380108	9.988837e-01	0.000
FCGR activation	R-HSA-2029481	9.990146e-01	0.000
ROS and RNS production in phagocytes	R-HSA-1222556	9.990391e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.991022e-01	0.000
O-glycosylation of TSR domain-containing proteins	R-HSA-5173214	9.991168e-01	0.000
Ubiquinol biosynthesis	R-HSA-2142789	9.991168e-01	0.000
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.991168e-01	0.000
Metabolism of folate and pterines	R-HSA-196757	9.991168e-01	0.000
Collagen chain trimerization	R-HSA-8948216	9.991168e-01	0.000
Citric acid cycle (TCA cycle)	R-HSA-71403	9.991535e-01	0.000
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.992474e-01	0.000
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.992605e-01	0.000
Scavenging of heme from plasma	R-HSA-2168880	9.993039e-01	0.000
Extracellular matrix organization	R-HSA-1474244	9.994459e-01	0.000
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.994535e-01	0.000
SLC-mediated transport of amino acids	R-HSA-9958863	9.994747e-01	0.000
O-linked glycosylation of mucins	R-HSA-913709	9.995414e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.995956e-01	0.000
Scavenging by Class A Receptors	R-HSA-3000480	9.996033e-01	0.000
Post-translational protein modification	R-HSA-597592	9.996934e-01	0.000
Metabolism of porphyrins	R-HSA-189445	9.996955e-01	0.000
Defensins	R-HSA-1461973	9.997120e-01	0.000
Amino acid transport across the plasma membrane	R-HSA-352230	9.997394e-01	0.000
Methylation	R-HSA-156581	9.997546e-01	0.000
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.997546e-01	0.000
Metabolism of polyamines	R-HSA-351202	9.997750e-01	0.000
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.997909e-01	0.000
Degradation of cysteine and homocysteine	R-HSA-1614558	9.997909e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.997975e-01	0.000
Transport of vitamins, nucleosides, and related molecules	R-HSA-425397	9.997983e-01	0.000
Collagen degradation	R-HSA-1442490	9.998057e-01	0.000
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.998482e-01	0.000
Classical antibody-mediated complement activation	R-HSA-173623	9.998616e-01	0.000
Xenobiotics	R-HSA-211981	9.998751e-01	0.000
SLC-mediated transport of organic anions	R-HSA-9955298	9.998840e-01	0.000
Cholesterol biosynthesis	R-HSA-191273	9.998840e-01	0.000
Nicotinate metabolism	R-HSA-196807	9.999198e-01	0.000
Metabolism of steroid hormones	R-HSA-196071	9.999198e-01	0.000
Complex IV assembly	R-HSA-9864848	9.999200e-01	0.000
Branched-chain amino acid catabolism	R-HSA-70895	9.999200e-01	0.000
Glycosphingolipid catabolism	R-HSA-9840310	9.999486e-01	0.000
Purine catabolism	R-HSA-74259	9.999618e-01	0.000
Metabolism of amine-derived hormones	R-HSA-209776	9.999641e-01	0.000
Keratinization	R-HSA-6805567	9.999774e-01	0.000
Sialic acid metabolism	R-HSA-4085001	9.999778e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999804e-01	0.000
Signaling by Retinoic Acid	R-HSA-5362517	9.999811e-01	0.000
Glutathione conjugation	R-HSA-156590	9.999811e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.999813e-01	0.000
Endogenous sterols	R-HSA-211976	9.999839e-01	0.000
Regulation of Complement cascade	R-HSA-977606	9.999875e-01	0.000
Complex I biogenesis	R-HSA-6799198	9.999883e-01	0.000
Latent infection - Other responses of Mtb to phagocytosis	R-HSA-1222499	9.999915e-01	0.000
Creation of C4 and C2 activators	R-HSA-166786	9.999917e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999958e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.999960e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.999961e-01	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	9.999962e-01	0.000
Metal ion assimilation from the host	R-HSA-9638482	9.999968e-01	0.000
Retinoid metabolism and transport	R-HSA-975634	9.999968e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.999972e-01	0.000
Initial triggering of complement	R-HSA-166663	9.999976e-01	0.000
Aspirin ADME	R-HSA-9749641	9.999976e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999980e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999986e-01	0.000
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.999991e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.999993e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.999993e-01	0.000
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.999993e-01	0.000
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.999993e-01	0.000
Complement cascade	R-HSA-166658	9.999994e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.999995e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.999996e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999996e-01	0.000
Sulfur amino acid metabolism	R-HSA-1614635	9.999998e-01	0.000
Bacterial Infection Pathways	R-HSA-9824439	9.999998e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999998e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999998e-01	0.000
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.999998e-01	0.000
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999998e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999999e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.999999e-01	0.000
Asparagine N-linked glycosylation	R-HSA-446203	9.999999e-01	0.000
Drug ADME	R-HSA-9748784	9.999999e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999999e-01	0.000
Nucleotide catabolism	R-HSA-8956319	1.000000e+00	0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000
Metabolism of steroids	R-HSA-8957322	1.000000e+00	0.000
Glycosphingolipid metabolism	R-HSA-1660662	1.000000e+00	0.000
Sphingolipid metabolism	R-HSA-428157	1.000000e+00	0.000
Sensory perception of taste	R-HSA-9717189	1.000000e+00	0.000
Respiratory electron transport	R-HSA-611105	1.000000e+00	0.000
Mitochondrial translation	R-HSA-5368287	1.000000e+00	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	1.000000e+00	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	1.000000e+00	0.000
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000e+00	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	1.000000e+00	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	-0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Cellular responses to stress	R-HSA-2262752	3.242117e-10	9.489
Cellular responses to stimuli	R-HSA-8953897	3.694127e-09	8.432
Eukaryotic Translation Initiation	R-HSA-72613	7.167478e-09	8.145
Cap-dependent Translation Initiation	R-HSA-72737	7.167478e-09	8.145
Cell Cycle	R-HSA-1640170	9.178718e-09	8.037
Cell Cycle, Mitotic	R-HSA-69278	1.289535e-08	7.890
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	2.912416e-08	7.536
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	2.912416e-08	7.536
Nervous system development	R-HSA-9675108	2.569772e-08	7.590
Metabolism of RNA	R-HSA-8953854	4.910502e-08	7.309
Axon guidance	R-HSA-422475	5.279394e-08	7.277
Chromatin organization	R-HSA-4839726	1.261972e-07	6.899
M Phase	R-HSA-68886	2.327955e-07	6.633
Chromatin modifying enzymes	R-HSA-3247509	2.426163e-07	6.615
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	3.542211e-07	6.451
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	6.270810e-07	6.203
Signaling by ROBO receptors	R-HSA-376176	7.001479e-07	6.155
Mitotic Anaphase	R-HSA-68882	7.352851e-07	6.134
Apoptotic execution phase	R-HSA-75153	7.937904e-07	6.100
Mitotic Metaphase and Anaphase	R-HSA-2555396	8.275107e-07	6.082
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	2.026242e-06	5.693
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	2.541711e-06	5.595
Separation of Sister Chromatids	R-HSA-2467813	3.924971e-06	5.406
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	4.417112e-06	5.355
Formation of a pool of free 40S subunits	R-HSA-72689	4.301055e-06	5.366
Translation initiation complex formation	R-HSA-72649	6.062183e-06	5.217
Epigenetic regulation of gene expression	R-HSA-212165	6.161227e-06	5.210
Eukaryotic Translation Elongation	R-HSA-156842	6.091471e-06	5.215
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	6.716229e-06	5.173
Influenza Viral RNA Transcription and Replication	R-HSA-168273	6.846967e-06	5.165
Cellular response to heat stress	R-HSA-3371556	8.211463e-06	5.086
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	8.211463e-06	5.086
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	9.783359e-06	5.010
Influenza Infection	R-HSA-168255	1.187133e-05	4.926
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.295649e-05	4.888
Signaling by ALK in cancer	R-HSA-9700206	1.295649e-05	4.888
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	1.434491e-05	4.843
Peptide chain elongation	R-HSA-156902	2.036171e-05	4.691
Cell-extracellular matrix interactions	R-HSA-446353	2.577974e-05	4.589
Mitotic Prometaphase	R-HSA-68877	2.555992e-05	4.592
Mitotic Spindle Checkpoint	R-HSA-69618	2.610622e-05	4.583
Ribosomal scanning and start codon recognition	R-HSA-72702	3.119431e-05	4.506
Apoptotic cleavage of cellular proteins	R-HSA-111465	3.593176e-05	4.445
Nuclear Envelope Breakdown	R-HSA-2980766	3.824839e-05	4.417
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	5.568032e-05	4.254
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	5.842472e-05	4.233
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	6.179854e-05	4.209
rRNA processing in the nucleus and cytosol	R-HSA-8868773	6.643787e-05	4.178
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	8.199709e-05	4.086
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	9.425354e-05	4.026
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	9.147173e-05	4.039
Amplification of signal from the kinetochores	R-HSA-141424	9.147173e-05	4.039
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	8.698899e-05	4.061
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	8.836385e-05	4.054
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.482934e-05	4.023
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.020814e-04	3.991
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.414693e-04	3.849
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.493863e-04	3.826
Nonsense-Mediated Decay (NMD)	R-HSA-927802	1.575190e-04	3.803
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	1.575190e-04	3.803
Recycling pathway of L1	R-HSA-437239	1.592780e-04	3.798
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	1.777160e-04	3.750
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	1.777931e-04	3.750
Eukaryotic Translation Termination	R-HSA-72764	2.036579e-04	3.691
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	2.261395e-04	3.646
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	2.376566e-04	3.624
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	2.554943e-04	3.593
Cellular Senescence	R-HSA-2559583	2.535774e-04	3.596
Interactions of Rev with host cellular proteins	R-HSA-177243	3.158857e-04	3.500
HSF1-dependent transactivation	R-HSA-3371571	3.422298e-04	3.466
Signal Transduction	R-HSA-162582	3.425027e-04	3.465
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	4.047079e-04	3.393
mRNA 3'-end processing	R-HSA-72187	4.094865e-04	3.388
Selenocysteine synthesis	R-HSA-2408557	4.418754e-04	3.355
mRNA Splicing - Major Pathway	R-HSA-72163	4.574663e-04	3.340
Signaling by RAF1 mutants	R-HSA-9656223	4.739747e-04	3.324
Ribosome-associated quality control	R-HSA-9948299	4.951205e-04	3.305
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	4.955103e-04	3.305
Oncogenic MAPK signaling	R-HSA-6802957	5.083313e-04	3.294
Mitotic Prophase	R-HSA-68875	5.120705e-04	3.291
Vpr-mediated nuclear import of PICs	R-HSA-180910	5.480687e-04	3.261
Regulation of PTEN gene transcription	R-HSA-8943724	5.622175e-04	3.250
Viral mRNA Translation	R-HSA-192823	5.632682e-04	3.249
Transport of the SLBP independent Mature mRNA	R-HSA-159227	6.229458e-04	3.206
Regulation of MECP2 expression and activity	R-HSA-9022692	6.229458e-04	3.206
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	6.306199e-04	3.200
Cell Cycle Checkpoints	R-HSA-69620	6.079828e-04	3.216
RNA Polymerase II Transcription Termination	R-HSA-73856	6.588083e-04	3.181
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	6.720009e-04	3.173
Nuclear import of Rev protein	R-HSA-180746	9.525031e-04	3.021
Membrane Trafficking	R-HSA-199991	9.997201e-04	3.000
Interactions of Vpr with host cellular proteins	R-HSA-176033	9.914665e-04	3.004
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.088974e-03	2.963
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.165176e-03	2.934
Signaling downstream of RAS mutants	R-HSA-9649948	1.186018e-03	2.926
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.186018e-03	2.926
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.186018e-03	2.926
Regulation of endogenous retroelements	R-HSA-9842860	1.120913e-03	2.950
mRNA Splicing	R-HSA-72172	1.124094e-03	2.949
Signaling by RAS mutants	R-HSA-6802949	1.186018e-03	2.926
Transcriptional Regulation by VENTX	R-HSA-8853884	1.193670e-03	2.923
ATP-dependent chromatin remodelers	R-HSA-9932444	1.214264e-03	2.916
SWI/SNF chromatin remodelers	R-HSA-9932451	1.214264e-03	2.916
Apoptosis	R-HSA-109581	1.297071e-03	2.887
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.349297e-03	2.870
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.349297e-03	2.870
Cell junction organization	R-HSA-446728	1.397246e-03	2.855
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	1.485272e-03	2.828
Kinesins	R-HSA-983189	1.485272e-03	2.828
L1CAM interactions	R-HSA-373760	1.511367e-03	2.821
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	1.638302e-03	2.786
MITF-M-dependent gene expression	R-HSA-9856651	1.686774e-03	2.773
Cellular response to starvation	R-HSA-9711097	1.755375e-03	2.756
IPs transport between nucleus and cytosol	R-HSA-1855170	2.023510e-03	2.694
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	2.314293e-03	2.636
Activation of AMPK downstream of NMDARs	R-HSA-9619483	2.361007e-03	2.627
NS1 Mediated Effects on Host Pathways	R-HSA-168276	2.446703e-03	2.611
DNA Damage Recognition in GG-NER	R-HSA-5696394	2.451113e-03	2.611
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	2.451113e-03	2.611
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	2.451809e-03	2.611
Regulation of CDH1 Function	R-HSA-9764561	2.457117e-03	2.610
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	2.463051e-03	2.609
Gene expression (Transcription)	R-HSA-74160	2.847539e-03	2.546
rRNA processing	R-HSA-72312	2.717823e-03	2.566
Attenuation phase	R-HSA-3371568	2.902466e-03	2.537
Aggrephagy	R-HSA-9646399	2.902466e-03	2.537
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	2.962911e-03	2.528
RUNX3 regulates WNT signaling	R-HSA-8951430	3.383887e-03	2.471
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	3.383887e-03	2.471
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	3.410471e-03	2.467
Regulation of CDH1 Expression and Function	R-HSA-9764265	3.410471e-03	2.467
Post NMDA receptor activation events	R-HSA-438064	3.864172e-03	2.413
Developmental Biology	R-HSA-1266738	4.110640e-03	2.386
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	4.387500e-03	2.358
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	4.946520e-03	2.306
MTOR signalling	R-HSA-165159	4.696324e-03	2.328
Cell-Cell communication	R-HSA-1500931	5.009886e-03	2.300
Formation of annular gap junctions	R-HSA-196025	5.033427e-03	2.298
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	5.033427e-03	2.298
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	5.065752e-03	2.295
Transcriptional regulation by RUNX1	R-HSA-8878171	5.229026e-03	2.282
Transcriptional Regulation by MECP2	R-HSA-8986944	5.869834e-03	2.231
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	5.936910e-03	2.226
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	6.060265e-03	2.218
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	6.766243e-03	2.170
Clathrin-mediated endocytosis	R-HSA-8856828	6.226603e-03	2.206
Signaling by Hippo	R-HSA-2028269	6.766243e-03	2.170
MITF-M-regulated melanocyte development	R-HSA-9730414	6.406186e-03	2.193
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	7.544243e-03	2.122
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	7.544243e-03	2.122
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	7.544243e-03	2.122
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	7.544243e-03	2.122
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	7.544243e-03	2.122
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	7.544243e-03	2.122
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	7.544243e-03	2.122
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	7.544243e-03	2.122
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	7.544243e-03	2.122
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	7.544243e-03	2.122
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	7.544243e-03	2.122
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	7.544243e-03	2.122
Gap junction degradation	R-HSA-190873	7.184359e-03	2.144
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	7.336371e-03	2.135
mTORC1-mediated signalling	R-HSA-166208	7.303028e-03	2.136
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	7.282426e-03	2.138
PKR-mediated signaling	R-HSA-9833482	7.567635e-03	2.121
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	7.702280e-03	2.113
Metabolism of non-coding RNA	R-HSA-194441	7.736278e-03	2.111
snRNP Assembly	R-HSA-191859	7.736278e-03	2.111
Glycolysis	R-HSA-70171	8.300781e-03	2.081
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	8.356938e-03	2.078
RAF activation	R-HSA-5673000	8.421923e-03	2.075
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	8.421923e-03	2.075
Transport of connexons to the plasma membrane	R-HSA-190872	8.503955e-03	2.070
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	8.530873e-03	2.069
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	8.893445e-03	2.051
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	8.893445e-03	2.051
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	8.989304e-03	2.046
Selective autophagy	R-HSA-9663891	8.989304e-03	2.046
PKMTs methylate histone lysines	R-HSA-3214841	9.124905e-03	2.040
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	9.124905e-03	2.040
MAP2K and MAPK activation	R-HSA-5674135	1.050507e-02	1.979
Apoptosis induced DNA fragmentation	R-HSA-140342	9.905551e-03	2.004
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	9.905551e-03	2.004
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	9.560096e-03	2.020
ISG15 antiviral mechanism	R-HSA-1169408	9.537775e-03	2.021
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.050507e-02	1.979
Interleukin-12 signaling	R-HSA-9020591	1.057734e-02	1.976
Programmed Cell Death	R-HSA-5357801	1.068660e-02	1.971
Deadenylation of mRNA	R-HSA-429947	1.072910e-02	1.969
HDACs deacetylate histones	R-HSA-3214815	1.101645e-02	1.958
Estrogen-dependent gene expression	R-HSA-9018519	1.106690e-02	1.956
HSF1 activation	R-HSA-3371511	1.143327e-02	1.942
Host Interactions of HIV factors	R-HSA-162909	1.164943e-02	1.934
Gap junction trafficking and regulation	R-HSA-157858	1.233441e-02	1.909
Transcriptional regulation by RUNX3	R-HSA-8878159	1.242102e-02	1.906
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.334903e-02	1.875
MET interacts with TNS proteins	R-HSA-8875513	1.371295e-02	1.863
G2/M Transition	R-HSA-69275	1.412357e-02	1.850
Diseases of mitotic cell cycle	R-HSA-9675126	1.431957e-02	1.844
HATs acetylate histones	R-HSA-3214847	1.473718e-02	1.832
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.694355e-02	1.771
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.694355e-02	1.771
Diseases of Telomere Maintenance	R-HSA-9673013	1.694355e-02	1.771
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.694355e-02	1.771
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.694355e-02	1.771
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	1.694355e-02	1.771
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	1.663070e-02	1.779
Myogenesis	R-HSA-525793	1.521917e-02	1.818
Nuclear RNA decay	R-HSA-9930044	1.663070e-02	1.779
Gap junction trafficking	R-HSA-190828	1.561488e-02	1.806
Mitotic G2-G2/M phases	R-HSA-453274	1.591710e-02	1.798
SARS-CoV-1-host interactions	R-HSA-9692914	1.510852e-02	1.821
Intracellular signaling by second messengers	R-HSA-9006925	1.759425e-02	1.755
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	1.767574e-02	1.753
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	1.883190e-02	1.725
Smooth Muscle Contraction	R-HSA-445355	1.971791e-02	1.705
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	2.059646e-02	1.686
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	2.168991e-02	1.664
AKT phosphorylates targets in the cytosol	R-HSA-198323	2.210087e-02	1.656
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	2.210087e-02	1.656
Adherens junctions interactions	R-HSA-418990	2.210739e-02	1.655
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	2.235515e-02	1.651
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	2.245055e-02	1.649
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	2.246616e-02	1.648
PTEN Regulation	R-HSA-6807070	2.359815e-02	1.627
Unfolded Protein Response (UPR)	R-HSA-381119	2.359815e-02	1.627
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	2.363031e-02	1.627
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	2.363031e-02	1.627
tRNA processing in the nucleus	R-HSA-6784531	2.363031e-02	1.627
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	2.429130e-02	1.615
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	2.429988e-02	1.614
Regulation of CDH11 Expression and Function	R-HSA-9759475	2.429988e-02	1.614
Nucleotide Excision Repair	R-HSA-5696398	2.559853e-02	1.592
EPH-Ephrin signaling	R-HSA-2682334	2.707857e-02	1.567
Depolymerization of the Nuclear Lamina	R-HSA-4419969	2.775305e-02	1.557
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	2.863611e-02	1.543
S Phase	R-HSA-69242	2.643651e-02	1.578
RNA Polymerase I Transcription Initiation	R-HSA-73762	2.853792e-02	1.545
Semaphorin interactions	R-HSA-373755	2.606594e-02	1.584
Regulation of CDH1 Gene Transcription	R-HSA-9764560	2.490612e-02	1.604
XBP1(S) activates chaperone genes	R-HSA-381038	2.885447e-02	1.540
Selenoamino acid metabolism	R-HSA-2408522	2.561199e-02	1.592
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.918093e-02	1.535
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	2.985141e-02	1.525
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	3.078454e-02	1.512
Chaperonin-mediated protein folding	R-HSA-390466	3.126386e-02	1.505
Interleukin-12 family signaling	R-HSA-447115	3.126386e-02	1.505
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	3.162239e-02	1.500
WNT mediated activation of DVL	R-HSA-201688	3.191150e-02	1.496
Calcineurin activates NFAT	R-HSA-2025928	3.191150e-02	1.496
Regulation of CDH11 gene transcription	R-HSA-9762293	3.191150e-02	1.496
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	3.213004e-02	1.493
Switching of origins to a post-replicative state	R-HSA-69052	3.257709e-02	1.487
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	3.262808e-02	1.486
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	3.262808e-02	1.486
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	3.262808e-02	1.486
Regulation of TP53 Activity	R-HSA-5633007	3.285141e-02	1.483
DNA Double-Strand Break Repair	R-HSA-5693532	3.549307e-02	1.450
Manipulation of host energy metabolism	R-HSA-9636667	3.575738e-02	1.447
Breakdown of the nuclear lamina	R-HSA-352238	3.575738e-02	1.447
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	3.634781e-02	1.440
Vesicle-mediated transport	R-HSA-5653656	3.665934e-02	1.436
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	4.537996e-02	1.343
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	4.537996e-02	1.343
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	4.537996e-02	1.343
Negative feedback regulation of MAPK pathway	R-HSA-5674499	4.537996e-02	1.343
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	4.537996e-02	1.343
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	4.091758e-02	1.388
PIP3 activates AKT signaling	R-HSA-1257604	4.605156e-02	1.337
Post-chaperonin tubulin folding pathway	R-HSA-389977	3.902415e-02	1.409
HIV Life Cycle	R-HSA-162587	4.427331e-02	1.354
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	4.152613e-02	1.382
Protein methylation	R-HSA-8876725	4.132096e-02	1.384
MAPK family signaling cascades	R-HSA-5683057	4.353636e-02	1.361
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	4.078225e-02	1.390
Viral Messenger RNA Synthesis	R-HSA-168325	4.361954e-02	1.360
Golgi-to-ER retrograde transport	R-HSA-8856688	3.986510e-02	1.399
Macroautophagy	R-HSA-1632852	4.391642e-02	1.357
Glucose metabolism	R-HSA-70326	3.859879e-02	1.413
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	4.616587e-02	1.336
Regulation of CDH19 Expression and Function	R-HSA-9764302	4.537996e-02	1.343
IRE1alpha activates chaperones	R-HSA-381070	4.556936e-02	1.341
Cell-cell junction organization	R-HSA-421270	4.634668e-02	1.334
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	4.684265e-02	1.329
Interaction between L1 and Ankyrins	R-HSA-445095	4.704132e-02	1.328
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	4.704132e-02	1.328
Protein folding	R-HSA-391251	4.891028e-02	1.311
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	4.897186e-02	1.310
Prolonged ERK activation events	R-HSA-169893	4.942742e-02	1.306
VEGFR2 mediated vascular permeability	R-HSA-5218920	5.083469e-02	1.294
Resolution of Abasic Sites (AP sites)	R-HSA-73933	5.083469e-02	1.294
HIV Infection	R-HSA-162906	5.118775e-02	1.291
Synthesis of DNA	R-HSA-69239	5.121224e-02	1.291
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	5.184266e-02	1.285
Loss of Nlp from mitotic centrosomes	R-HSA-380259	5.184266e-02	1.285
rRNA modification in the nucleus and cytosol	R-HSA-6790901	5.184266e-02	1.285
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	5.284362e-02	1.277
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	5.284362e-02	1.277
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	5.284362e-02	1.277
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	5.284362e-02	1.277
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	5.284362e-02	1.277
SARS-CoV-2-host interactions	R-HSA-9705683	5.344869e-02	1.272
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	5.348016e-02	1.272
Transcriptional regulation by small RNAs	R-HSA-5578749	5.680592e-02	1.246
Disorders of Developmental Biology	R-HSA-9675151	5.840387e-02	1.234
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	5.840387e-02	1.234
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	5.907673e-02	1.229
Regulation of TP53 Expression	R-HSA-6804754	5.965706e-02	1.224
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	5.965706e-02	1.224
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	6.022742e-02	1.220
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	6.027979e-02	1.220
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	6.130067e-02	1.213
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	7.704023e-02	1.113
SOS-mediated signalling	R-HSA-112412	7.704023e-02	1.113
Cohesin Loading onto Chromatin	R-HSA-2470946	7.704023e-02	1.113
Recycling of eIF2:GDP	R-HSA-72731	7.704023e-02	1.113
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	7.704023e-02	1.113
Activation of RAC1	R-HSA-428540	6.229062e-02	1.206
Signaling by GSK3beta mutants	R-HSA-5339716	6.229062e-02	1.206
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	7.489035e-02	1.126
RUNX3 regulates p14-ARF	R-HSA-8951936	7.489035e-02	1.126
Disorders of Nervous System Development	R-HSA-9697154	7.489035e-02	1.126
Pervasive developmental disorders	R-HSA-9005895	7.489035e-02	1.126
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	7.489035e-02	1.126
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	7.489035e-02	1.126
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	7.489035e-02	1.126
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	7.489035e-02	1.126
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	7.489035e-02	1.126
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	7.489035e-02	1.126
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	6.929352e-02	1.159
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	7.243083e-02	1.140
AURKA Activation by TPX2	R-HSA-8854518	6.604889e-02	1.180
Centrosome maturation	R-HSA-380287	7.098751e-02	1.149
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	6.935615e-02	1.159
DNA Double Strand Break Response	R-HSA-5693606	7.129896e-02	1.147
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	6.689919e-02	1.175
Mitotic Telophase/Cytokinesis	R-HSA-68884	6.229062e-02	1.206
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	7.489035e-02	1.126
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	6.793916e-02	1.168
Translation	R-HSA-72766	6.190849e-02	1.208
TBC/RABGAPs	R-HSA-8854214	6.846132e-02	1.165
COPI-mediated anterograde transport	R-HSA-6807878	6.820193e-02	1.166
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	7.696797e-02	1.114
RMTs methylate histone arginines	R-HSA-3214858	7.509002e-02	1.124
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	6.229062e-02	1.206
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	7.596632e-02	1.119
Cytokine Signaling in Immune system	R-HSA-1280215	7.019599e-02	1.154
ESR-mediated signaling	R-HSA-8939211	7.715119e-02	1.113
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	7.850996e-02	1.105
Signaling by ERBB2 ECD mutants	R-HSA-9665348	7.895519e-02	1.103
Ephrin signaling	R-HSA-3928664	7.895519e-02	1.103
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	8.258716e-02	1.083
HCMV Early Events	R-HSA-9609690	8.545285e-02	1.068
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	8.752722e-02	1.058
Invadopodia formation	R-HSA-8941237	8.752722e-02	1.058
Long-term potentiation	R-HSA-9620244	8.838097e-02	1.054
TGFBR3 expression	R-HSA-9839394	8.838097e-02	1.054
Sema4D in semaphorin signaling	R-HSA-400685	8.838097e-02	1.054
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	8.866898e-02	1.052
Frs2-mediated activation	R-HSA-170968	8.866898e-02	1.052
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	8.866898e-02	1.052
MHC class II antigen presentation	R-HSA-2132295	8.878997e-02	1.052
Heme signaling	R-HSA-9707616	8.956157e-02	1.048
DNA Repair	R-HSA-73894	9.108506e-02	1.041
VEGFA-VEGFR2 Pathway	R-HSA-4420097	9.161851e-02	1.038
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	9.357375e-02	1.029
Loss of Function of TP53 in Cancer	R-HSA-9723907	9.357375e-02	1.029
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	9.357375e-02	1.029
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	9.361178e-02	1.029
Cargo trafficking to the periciliary membrane	R-HSA-5620920	9.493544e-02	1.023
Type I hemidesmosome assembly	R-HSA-446107	9.565931e-02	1.019
Signaling by MRAS-complex mutants	R-HSA-9660537	9.565931e-02	1.019
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	9.565931e-02	1.019
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	9.565931e-02	1.019
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	9.715470e-02	1.013
Signaling by NOTCH3	R-HSA-9012852	9.715470e-02	1.013
Oxidative Stress Induced Senescence	R-HSA-2559580	9.735478e-02	1.012
Autophagy	R-HSA-9612973	9.821967e-02	1.008
RAF/MAP kinase cascade	R-HSA-5673001	9.826553e-02	1.008
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	9.889630e-02	1.005
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	9.889630e-02	1.005
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	9.889630e-02	1.005
Signaling by Interleukins	R-HSA-449147	1.012590e-01	0.995
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	1.015081e-01	0.993
Signaling by NTRKs	R-HSA-166520	1.018599e-01	0.992
VxPx cargo-targeting to cilium	R-HSA-5620916	1.028739e-01	0.988
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.028739e-01	0.988
Regulation of gap junction activity	R-HSA-191650	1.184165e-01	0.927
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	1.184165e-01	0.927
Inhibition of TSC complex formation by PKB	R-HSA-165181	1.184165e-01	0.927
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	1.184165e-01	0.927
AKT-mediated inactivation of FOXO1A	R-HSA-211163	1.184165e-01	0.927
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	1.184165e-01	0.927
PLCG1 events in ERBB2 signaling	R-HSA-1251932	1.184165e-01	0.927
GP1b-IX-V activation signalling	R-HSA-430116	1.159065e-01	0.936
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	1.159065e-01	0.936
Inactivation of CDC42 and RAC1	R-HSA-428543	1.159065e-01	0.936
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.159065e-01	0.936
ALK mutants bind TKIs	R-HSA-9700645	1.159065e-01	0.936
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.375925e-01	0.861
2-LTR circle formation	R-HSA-164843	1.375925e-01	0.861
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	1.035714e-01	0.985
Sema3A PAK dependent Axon repulsion	R-HSA-399954	1.195320e-01	0.923
IRF3-mediated induction of type I IFN	R-HSA-3270619	1.195320e-01	0.923
Beta-catenin phosphorylation cascade	R-HSA-196299	1.195320e-01	0.923
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	1.364764e-01	0.865
Phosphorylation of the APC/C	R-HSA-176412	1.364764e-01	0.865
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	1.364764e-01	0.865
Striated Muscle Contraction	R-HSA-390522	1.032199e-01	0.986
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	1.133403e-01	0.946
Chromosome Maintenance	R-HSA-73886	1.236261e-01	0.908
Regulation of CDH11 function	R-HSA-9762292	1.375925e-01	0.861
UCH proteinases	R-HSA-5689603	1.304304e-01	0.885
Homology Directed Repair	R-HSA-5693538	1.068823e-01	0.971
Signal attenuation	R-HSA-74749	1.375925e-01	0.861
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.370249e-01	0.863
MAPK1/MAPK3 signaling	R-HSA-5684996	1.226918e-01	0.911
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	1.100416e-01	0.958
Gap junction assembly	R-HSA-190861	1.133403e-01	0.946
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	1.364764e-01	0.865
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	1.184165e-01	0.927
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.159065e-01	0.936
Unwinding of DNA	R-HSA-176974	1.159065e-01	0.936
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	1.364764e-01	0.865
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.100416e-01	0.958
Early Phase of HIV Life Cycle	R-HSA-162594	1.160335e-01	0.935
NGF-stimulated transcription	R-HSA-9031628	1.054080e-01	0.977
Death Receptor Signaling	R-HSA-73887	1.316723e-01	0.881
MAPK6/MAPK4 signaling	R-HSA-5687128	1.337571e-01	0.874
RUNX2 regulates bone development	R-HSA-8941326	1.350691e-01	0.869
p75 NTR receptor-mediated signalling	R-HSA-193704	1.315115e-01	0.881
Interferon Signaling	R-HSA-913531	1.069149e-01	0.971
Cellular response to mitochondrial stress	R-HSA-9840373	1.159065e-01	0.936
Josephin domain DUBs	R-HSA-5689877	1.375925e-01	0.861
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.083457e-01	0.965
NRAGE signals death through JNK	R-HSA-193648	1.047111e-01	0.980
Assembly of the pre-replicative complex	R-HSA-68867	1.436660e-01	0.843
Deubiquitination	R-HSA-5688426	1.441783e-01	0.841
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.446261e-01	0.840
G alpha (12/13) signalling events	R-HSA-416482	1.464343e-01	0.834
RNA Polymerase I Transcription	R-HSA-73864	1.464343e-01	0.834
Degradation of DVL	R-HSA-4641258	1.466470e-01	0.834
Ovarian tumor domain proteases	R-HSA-5689896	1.466470e-01	0.834
Activation of the pre-replicative complex	R-HSA-68962	1.470593e-01	0.833
Downregulation of ERBB2 signaling	R-HSA-8863795	1.470593e-01	0.833
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	1.470593e-01	0.833
Viral Infection Pathways	R-HSA-9824446	1.477307e-01	0.831
Circadian clock	R-HSA-9909396	1.485548e-01	0.828
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	1.515167e-01	0.820
IRS activation	R-HSA-74713	1.515167e-01	0.820
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	1.515167e-01	0.820
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	1.515167e-01	0.820
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	1.515167e-01	0.820
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	1.515167e-01	0.820
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	1.516269e-01	0.819
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	1.516269e-01	0.819
SARS-CoV-1 Infection	R-HSA-9678108	1.529502e-01	0.815
Processing of Intronless Pre-mRNAs	R-HSA-77595	1.543237e-01	0.812
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	1.543237e-01	0.812
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	1.543237e-01	0.812
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	1.543237e-01	0.812
Signaling by VEGF	R-HSA-194138	1.547731e-01	0.810
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	1.555171e-01	0.808
Nucleosome assembly	R-HSA-774815	1.555171e-01	0.808
DAG and IP3 signaling	R-HSA-1489509	1.555171e-01	0.808
Signaling by APC mutants	R-HSA-4839744	1.605232e-01	0.794
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.605232e-01	0.794
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.605232e-01	0.794
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.605232e-01	0.794
Regulation of localization of FOXO transcription factors	R-HSA-9614399	1.605232e-01	0.794
NoRC negatively regulates rRNA expression	R-HSA-427413	1.606219e-01	0.794
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	1.619122e-01	0.791
Signaling by PTK6	R-HSA-8848021	1.665495e-01	0.778
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	1.665495e-01	0.778
mRNA Splicing - Minor Pathway	R-HSA-72165	1.667850e-01	0.778
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	1.667850e-01	0.778
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	1.783965e-01	0.749
Drug-mediated inhibition of MET activation	R-HSA-9734091	1.783965e-01	0.749
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function	R-HSA-9645722	1.783965e-01	0.749
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	1.783965e-01	0.749
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	1.861441e-01	0.730
Noncanonical activation of NOTCH3	R-HSA-9017802	1.861441e-01	0.730
PTK6 Regulates Cell Cycle	R-HSA-8849470	1.861441e-01	0.730
PTK6 promotes HIF1A stabilization	R-HSA-8857538	2.217236e-01	0.654
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	2.217236e-01	0.654
Autointegration results in viral DNA circles	R-HSA-177539	2.217236e-01	0.654
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	1.845045e-01	0.734
RUNX3 regulates NOTCH signaling	R-HSA-8941856	2.093464e-01	0.679
Scavenging by Class F Receptors	R-HSA-3000484	2.093464e-01	0.679
Formation of axial mesoderm	R-HSA-9796292	2.348659e-01	0.629
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	2.348659e-01	0.629
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	1.923803e-01	0.716
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	1.757948e-01	0.755
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	2.124098e-01	0.673
Impaired BRCA2 binding to PALB2	R-HSA-9709603	2.124098e-01	0.673
Co-inhibition by CTLA4	R-HSA-389513	2.329850e-01	0.633
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	2.329850e-01	0.633
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	2.329850e-01	0.633
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	2.329850e-01	0.633
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	2.329850e-01	0.633
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	1.744685e-01	0.758
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	2.267667e-01	0.644
Dual Incision in GG-NER	R-HSA-5696400	2.190572e-01	0.659
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	1.784140e-01	0.749
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	1.784140e-01	0.749
RET signaling	R-HSA-8853659	2.506858e-01	0.601
Developmental Lineages of the Mammary Gland	R-HSA-9924644	1.698974e-01	0.770
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	2.061615e-01	0.686
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	2.413555e-01	0.617
Formation of RNA Pol II elongation complex	R-HSA-112382	2.413555e-01	0.617
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	1.992108e-01	0.701
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	1.840096e-01	0.735
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	1.840096e-01	0.735
Degradation of beta-catenin by the destruction complex	R-HSA-195253	2.421471e-01	0.616
Signaling by EGFR	R-HSA-177929	1.834412e-01	0.737
DNA strand elongation	R-HSA-69190	1.744685e-01	0.758
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	2.001741e-01	0.699
Integration of provirus	R-HSA-162592	1.845045e-01	0.734
DNA Damage Bypass	R-HSA-73893	2.026877e-01	0.693
Signaling by ERBB2	R-HSA-1227986	2.299576e-01	0.638
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	1.757948e-01	0.755
Formation of Incision Complex in GG-NER	R-HSA-5696395	1.840096e-01	0.735
Transcriptional Regulation by TP53	R-HSA-3700989	2.386872e-01	0.622
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	1.840096e-01	0.735
PLC beta mediated events	R-HSA-112043	2.422199e-01	0.616
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	2.085149e-01	0.681
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	2.092945e-01	0.679
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	1.923803e-01	0.716
Ca-dependent events	R-HSA-111996	2.248408e-01	0.648
RNA Polymerase I Promoter Clearance	R-HSA-73854	2.094482e-01	0.679
RNA Polymerase II Transcription	R-HSA-73857	2.061682e-01	0.686
Late Phase of HIV Life Cycle	R-HSA-162599	1.675395e-01	0.776
TCF dependent signaling in response to WNT	R-HSA-201681	2.009587e-01	0.697
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	1.729880e-01	0.762
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	2.124098e-01	0.673
CaM pathway	R-HSA-111997	2.506858e-01	0.601
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.974640e-01	0.705
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	2.421471e-01	0.616
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	2.347060e-01	0.629
Calmodulin induced events	R-HSA-111933	2.506858e-01	0.601
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	2.348659e-01	0.629
Signalling to ERKs	R-HSA-187687	2.347060e-01	0.629
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	2.413555e-01	0.617
DNA Replication Pre-Initiation	R-HSA-69002	2.171706e-01	0.663
MAP kinase activation	R-HSA-450294	2.422199e-01	0.616
DNA Replication	R-HSA-69306	2.466263e-01	0.608
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	2.421471e-01	0.616
Cilium Assembly	R-HSA-5617833	2.483333e-01	0.605
G1/S Transition	R-HSA-69206	2.223534e-01	0.653
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	2.087959e-01	0.680
Formation of editosomes by ADAR proteins	R-HSA-77042	1.783965e-01	0.749
Signaling by AXIN mutants	R-HSA-4839735	1.845045e-01	0.734
Signaling by AMER1 mutants	R-HSA-4839748	1.845045e-01	0.734
Signaling by LTK	R-HSA-9842663	2.093464e-01	0.679
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	2.348659e-01	0.629
Degradation of CDH1	R-HSA-9766229	2.026877e-01	0.693
Deadenylation-dependent mRNA decay	R-HSA-429914	2.179328e-01	0.662
Orc1 removal from chromatin	R-HSA-68949	2.413555e-01	0.617
Maternal to zygotic transition (MZT)	R-HSA-9816359	1.983547e-01	0.703
Negative regulation of MAPK pathway	R-HSA-5675221	2.108861e-01	0.676
Rab regulation of trafficking	R-HSA-9007101	2.242334e-01	0.649
Protein-protein interactions at synapses	R-HSA-6794362	2.098980e-01	0.678
STING mediated induction of host immune responses	R-HSA-1834941	2.124098e-01	0.673
ER to Golgi Anterograde Transport	R-HSA-199977	2.016714e-01	0.695
G2/M Checkpoints	R-HSA-69481	2.390261e-01	0.622
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	1.908319e-01	0.719
Integration of viral DNA into host genomic DNA	R-HSA-175567	2.217236e-01	0.654
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	2.348659e-01	0.629
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	2.037769e-01	0.691
Formation of definitive endoderm	R-HSA-9823730	2.329850e-01	0.633
Transcriptional Regulation by E2F6	R-HSA-8953750	1.711384e-01	0.767
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	1.861441e-01	0.730
Transcriptional regulation by RUNX2	R-HSA-8878166	2.415668e-01	0.617
Uptake and function of anthrax toxins	R-HSA-5210891	1.729880e-01	0.762
Gene Silencing by RNA	R-HSA-211000	2.000189e-01	0.699
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	1.923803e-01	0.716
Inositol phosphate metabolism	R-HSA-1483249	2.440392e-01	0.613
SARS-CoV Infections	R-HSA-9679506	1.739010e-01	0.760
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	2.524615e-01	0.598
EPHB-mediated forward signaling	R-HSA-3928662	2.536491e-01	0.596
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	2.540153e-01	0.595
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	2.540153e-01	0.595
Signaling by TCF7L2 mutants	R-HSA-5339700	2.552861e-01	0.593
Defective VWF binding to collagen type I	R-HSA-9845622	2.552861e-01	0.593
Defective MMADHC causes MMAHCD	R-HSA-3359473	2.552861e-01	0.593
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	3.249841e-01	0.488
Regulation of cortical dendrite branching	R-HSA-8985801	3.249841e-01	0.488
Enhanced cleavage of VWF variant by ADAMTS13	R-HSA-9845619	3.249841e-01	0.488
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.249841e-01	0.488
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.249841e-01	0.488
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	3.249841e-01	0.488
Defective VWF cleavage by ADAMTS13 variant	R-HSA-9845621	3.249841e-01	0.488
MECP2 regulates transcription factors	R-HSA-9022707	2.577742e-01	0.589
IFNG signaling activates MAPKs	R-HSA-9732724	2.577742e-01	0.589
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	3.881628e-01	0.411
Defective MMACHC causes MAHCC	R-HSA-3359474	3.881628e-01	0.411
Defective DPM1 causes DPM1-CDG	R-HSA-4717374	3.881628e-01	0.411
MET activates PTPN11	R-HSA-8865999	3.881628e-01	0.411
Defective DPM2 causes DPM2-CDG	R-HSA-4719377	3.881628e-01	0.411
Adrenaline signalling through Alpha-2 adrenergic receptor	R-HSA-392023	3.881628e-01	0.411
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	3.881628e-01	0.411
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	3.881628e-01	0.411
Defective DPM3 causes DPM3-CDG	R-HSA-4719360	3.881628e-01	0.411
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	2.938965e-01	0.532
Myoclonic epilepsy of Lafora	R-HSA-3785653	2.938965e-01	0.532
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	2.608890e-01	0.584
ARMS-mediated activation	R-HSA-170984	3.297615e-01	0.482
Lipophagy	R-HSA-9613354	3.297615e-01	0.482
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	4.454317e-01	0.351
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	4.454317e-01	0.351
GRB7 events in ERBB2 signaling	R-HSA-1306955	4.454317e-01	0.351
Signaling by MAP2K mutants	R-HSA-9652169	4.454317e-01	0.351
Erythropoietin activates RAS	R-HSA-9027284	2.872526e-01	0.542
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	2.872526e-01	0.542
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	3.651014e-01	0.438
MET activates RAP1 and RAC1	R-HSA-8875555	3.651014e-01	0.438
Folding of actin by CCT/TriC	R-HSA-390450	3.651014e-01	0.438
Listeria monocytogenes entry into host cells	R-HSA-8876384	2.754116e-01	0.560
Signaling by ERBB2 KD Mutants	R-HSA-9664565	2.628800e-01	0.580
GRB2 events in ERBB2 signaling	R-HSA-1963640	3.404067e-01	0.468
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	3.997003e-01	0.398
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	3.997003e-01	0.398
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	4.973431e-01	0.303
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	4.973431e-01	0.303
Signaling by ERBB2 in Cancer	R-HSA-1227990	2.814098e-01	0.551
Signaling by EGFRvIII in Cancer	R-HSA-5637812	3.669313e-01	0.435
Constitutive Signaling by EGFRvIII	R-HSA-5637810	3.669313e-01	0.435
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	3.669313e-01	0.435
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	3.001814e-01	0.523
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	4.333876e-01	0.363
RNA Polymerase II Transcription Elongation	R-HSA-75955	2.547658e-01	0.594
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	2.547658e-01	0.594
Polymerase switching on the C-strand of the telomere	R-HSA-174411	3.629750e-01	0.440
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	3.629750e-01	0.440
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	2.822395e-01	0.549
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	2.962587e-01	0.528
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	2.962587e-01	0.528
MET activates RAS signaling	R-HSA-8851805	4.660309e-01	0.332
Repression of WNT target genes	R-HSA-4641265	4.660309e-01	0.332
Polymerase switching	R-HSA-69091	4.660309e-01	0.332
Leading Strand Synthesis	R-HSA-69109	4.660309e-01	0.332
GRB2 events in EGFR signaling	R-HSA-179812	4.660309e-01	0.332
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	3.766293e-01	0.424
Processive synthesis on the C-strand of the telomere	R-HSA-174414	4.068732e-01	0.391
EPHA-mediated growth cone collapse	R-HSA-3928663	4.068732e-01	0.391
Regulation of RAS by GAPs	R-HSA-5658442	3.452387e-01	0.462
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	4.449598e-01	0.352
Negative regulation of MET activity	R-HSA-6807004	4.449598e-01	0.352
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	4.975304e-01	0.303
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	3.767336e-01	0.424
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	3.402036e-01	0.468
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	3.604005e-01	0.443
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	4.701534e-01	0.328
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	4.701534e-01	0.328
Lagging Strand Synthesis	R-HSA-69186	4.701534e-01	0.328
TNFR1-induced proapoptotic signaling	R-HSA-5357786	4.701534e-01	0.328
Impaired BRCA2 binding to RAD51	R-HSA-9709570	4.501417e-01	0.347
MET promotes cell motility	R-HSA-8875878	4.529352e-01	0.344
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	4.545644e-01	0.342
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	4.715024e-01	0.327
Regulation of RUNX3 expression and activity	R-HSA-8941858	4.901942e-01	0.310
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	4.706012e-01	0.327
Telomere Maintenance	R-HSA-157579	4.930969e-01	0.307
Extension of Telomeres	R-HSA-180786	3.391777e-01	0.470
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	3.513710e-01	0.454
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	3.339111e-01	0.476
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	2.754116e-01	0.560
Adipogenesis	R-HSA-9843745	3.746565e-01	0.426
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	3.669313e-01	0.435
EGFR downregulation	R-HSA-182971	4.923473e-01	0.308
Developmental Cell Lineages	R-HSA-9734767	4.350011e-01	0.362
Golgi Associated Vesicle Biogenesis	R-HSA-432722	2.547658e-01	0.594
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	4.449598e-01	0.352
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	4.031207e-01	0.395
Asymmetric localization of PCP proteins	R-HSA-4608870	4.203446e-01	0.376
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	4.714013e-01	0.327
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	5.084777e-01	0.294
Platelet Aggregation (Plug Formation)	R-HSA-76009	4.203446e-01	0.376
Transcriptional regulation of testis differentiation	R-HSA-9690406	3.404067e-01	0.468
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	3.382358e-01	0.471
SHC1 events in ERBB2 signaling	R-HSA-1250196	4.714013e-01	0.327
Interleukin-15 signaling	R-HSA-8983432	4.660309e-01	0.332
G1 Phase	R-HSA-69236	4.031207e-01	0.395
Cyclin D associated events in G1	R-HSA-69231	4.031207e-01	0.395
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	2.938965e-01	0.532
PI3K/AKT activation	R-HSA-198203	3.651014e-01	0.438
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	4.333876e-01	0.363
Regulation of Apoptosis	R-HSA-169911	3.958319e-01	0.402
Cyclin E associated events during G1/S transition	R-HSA-69202	3.604005e-01	0.443
Chaperone Mediated Autophagy	R-HSA-9613829	3.932644e-01	0.405
Resolution of D-Loop Structures	R-HSA-5693537	3.574149e-01	0.447
Regulation of TNFR1 signaling	R-HSA-5357905	4.375024e-01	0.359
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	4.973431e-01	0.303
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	3.189589e-01	0.496
NF-kB is activated and signals survival	R-HSA-209560	4.333876e-01	0.363
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	3.382358e-01	0.471
Translesion Synthesis by POLH	R-HSA-110320	4.193039e-01	0.377
VLDLR internalisation and degradation	R-HSA-8866427	4.660309e-01	0.332
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	4.660309e-01	0.332
RNA Polymerase I Transcription Termination	R-HSA-73863	4.068732e-01	0.391
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	3.740723e-01	0.427
Regulation of mitotic cell cycle	R-HSA-453276	3.740723e-01	0.427
Trafficking of AMPA receptors	R-HSA-399719	4.923473e-01	0.308
Beta-catenin independent WNT signaling	R-HSA-3858494	3.384208e-01	0.471
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	2.626418e-01	0.581
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	2.970873e-01	0.527
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	4.660309e-01	0.332
PCP/CE pathway	R-HSA-4086400	3.402036e-01	0.468
RNA Polymerase II Pre-transcription Events	R-HSA-674695	2.900325e-01	0.538
TNF signaling	R-HSA-75893	4.398681e-01	0.357
Signaling by WNT	R-HSA-195721	4.698245e-01	0.328
Hedgehog 'off' state	R-HSA-5610787	3.005338e-01	0.522
trans-Golgi Network Vesicle Budding	R-HSA-199992	2.657451e-01	0.576
Killing mechanisms	R-HSA-9664420	3.138049e-01	0.503
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	3.138049e-01	0.503
Formation of the posterior neural plate	R-HSA-9832991	3.997003e-01	0.398
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	4.973431e-01	0.303
Activation of AKT2	R-HSA-165158	4.973431e-01	0.303
Post-transcriptional silencing by small RNAs	R-HSA-426496	4.973431e-01	0.303
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	2.814098e-01	0.551
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	4.975304e-01	0.303
Hh mutants are degraded by ERAD	R-HSA-5362768	5.084777e-01	0.294
Signaling by WNT in cancer	R-HSA-4791275	3.191410e-01	0.496
HDR through Homologous Recombination (HRR)	R-HSA-5685942	3.198177e-01	0.495
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	4.454317e-01	0.351
Transcriptional activation of p53 responsive genes	R-HSA-69560	4.454317e-01	0.351
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	4.454317e-01	0.351
Regulation of PD-L1(CD274) expression	R-HSA-9909648	5.093373e-01	0.293
G-protein mediated events	R-HSA-112040	3.198177e-01	0.495
Regulation of gene expression in beta cells	R-HSA-210745	4.501417e-01	0.347
HCMV Infection	R-HSA-9609646	2.731542e-01	0.564
Interleukin-1 signaling	R-HSA-9020702	4.211122e-01	0.376
Regulation of TP53 Expression and Degradation	R-HSA-6806003	4.716695e-01	0.326
Response of endothelial cells to shear stress	R-HSA-9860931	4.563749e-01	0.341
Opioid Signalling	R-HSA-111885	4.563749e-01	0.341
Cellular responses to mechanical stimuli	R-HSA-9855142	4.674143e-01	0.330
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	3.297615e-01	0.482
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	3.404067e-01	0.468
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	3.766293e-01	0.424
CD209 (DC-SIGN) signaling	R-HSA-5621575	3.409467e-01	0.467
Interleukin-17 signaling	R-HSA-448424	3.604005e-01	0.443
Mismatch Repair	R-HSA-5358508	3.932644e-01	0.405
Neurexins and neuroligins	R-HSA-6794361	3.767336e-01	0.424
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	4.223802e-01	0.374
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	2.552861e-01	0.593
Inhibition of Host mRNA Processing and RNA Silencing	R-HSA-168315	2.552861e-01	0.593
Transport of connexins along the secretory pathway	R-HSA-190827	2.552861e-01	0.593
mRNA Editing: A to I Conversion	R-HSA-75064	3.249841e-01	0.488
Interleukin-33 signaling	R-HSA-9014843	3.249841e-01	0.488
C6 deamination of adenosine	R-HSA-75102	3.249841e-01	0.488
MET activates STAT3	R-HSA-8875791	3.881628e-01	0.411
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	4.454317e-01	0.351
EGFR Transactivation by Gastrin	R-HSA-2179392	3.651014e-01	0.438
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	3.138049e-01	0.503
Regulation of gene expression in early pancreatic precursor cells	R-HSA-210747	3.997003e-01	0.398
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	4.973431e-01	0.303
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	3.766293e-01	0.424
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	3.609583e-01	0.443
DARPP-32 events	R-HSA-180024	4.501417e-01	0.347
MyD88-independent TLR4 cascade	R-HSA-166166	4.223802e-01	0.374
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	4.882900e-01	0.311
p53-Dependent G1 DNA Damage Response	R-HSA-69563	4.882900e-01	0.311
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	3.662077e-01	0.436
Diseases of programmed cell death	R-HSA-9645723	4.822173e-01	0.317
Transcriptional regulation of granulopoiesis	R-HSA-9616222	3.829223e-01	0.417
Co-stimulation by CD28	R-HSA-389356	3.140761e-01	0.503
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	3.877865e-01	0.411
HDMs demethylate histones	R-HSA-3214842	3.629750e-01	0.440
Protein ubiquitination	R-HSA-8852135	3.023981e-01	0.519
Stabilization of p53	R-HSA-69541	4.716695e-01	0.326
Neurodegenerative Diseases	R-HSA-8863678	3.409467e-01	0.467
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	3.409467e-01	0.467
Glycogen metabolism	R-HSA-8982491	4.901942e-01	0.310
PTK6 Activates STAT3	R-HSA-8849474	4.973431e-01	0.303
ERK/MAPK targets	R-HSA-198753	4.701534e-01	0.328
Interleukin-7 signaling	R-HSA-1266695	3.629750e-01	0.440
Organelle biogenesis and maintenance	R-HSA-1852241	4.820338e-01	0.317
DCC mediated attractive signaling	R-HSA-418885	2.872526e-01	0.542
Extra-nuclear estrogen signaling	R-HSA-9009391	4.211122e-01	0.376
Uptake and function of diphtheria toxin	R-HSA-5336415	2.577742e-01	0.589
Activation of PUMA and translocation to mitochondria	R-HSA-139915	2.577742e-01	0.589
CHL1 interactions	R-HSA-447041	2.577742e-01	0.589
Regulated proteolysis of p75NTR	R-HSA-193692	3.297615e-01	0.482
Activation of NOXA and translocation to mitochondria	R-HSA-111448	4.454317e-01	0.351
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	2.970873e-01	0.527
Synthesis of PG	R-HSA-1483148	3.404067e-01	0.468
Muscarinic acetylcholine receptors	R-HSA-390648	4.973431e-01	0.303
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	3.766293e-01	0.424
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	4.701534e-01	0.328
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	4.529352e-01	0.344
MyD88 cascade initiated on plasma membrane	R-HSA-975871	5.051760e-01	0.297
Muscle contraction	R-HSA-397014	4.275116e-01	0.369
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	5.051760e-01	0.297
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	5.051760e-01	0.297
Intrinsic Pathway for Apoptosis	R-HSA-109606	4.398681e-01	0.357
PI3K/AKT Signaling in Cancer	R-HSA-2219528	4.234243e-01	0.373
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	4.660309e-01	0.332
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	4.501417e-01	0.347
Base Excision Repair	R-HSA-73884	3.826194e-01	0.417
Platelet degranulation	R-HSA-114608	4.242870e-01	0.372
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	3.829223e-01	0.417
Generation of second messenger molecules	R-HSA-202433	3.171479e-01	0.499
Cellular response to hypoxia	R-HSA-1234174	2.933029e-01	0.533
Signaling by TGFBR3	R-HSA-9839373	2.834701e-01	0.547
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	3.140632e-01	0.503
Oligomerization of connexins into connexons	R-HSA-190704	2.552861e-01	0.593
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	3.881628e-01	0.411
Intracellular oxygen transport	R-HSA-8981607	3.881628e-01	0.411
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	4.454317e-01	0.351
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	3.651014e-01	0.438
Signaling by PDGFR in disease	R-HSA-9671555	2.754116e-01	0.560
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	4.973431e-01	0.303
Interleukin-36 pathway	R-HSA-9014826	4.973431e-01	0.303
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	4.333876e-01	0.363
G2/M DNA damage checkpoint	R-HSA-69473	4.152733e-01	0.382
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	5.084777e-01	0.294
Activation of BH3-only proteins	R-HSA-114452	4.714013e-01	0.327
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	4.286151e-01	0.368
Non-integrin membrane-ECM interactions	R-HSA-3000171	3.023981e-01	0.519
Protein hydroxylation	R-HSA-9629569	4.449598e-01	0.352
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	3.767336e-01	0.424
Cardiogenesis	R-HSA-9733709	3.382358e-01	0.471
Gluconeogenesis	R-HSA-70263	4.715024e-01	0.327
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	3.297615e-01	0.482
PECAM1 interactions	R-HSA-210990	3.997003e-01	0.398
Suppression of apoptosis	R-HSA-9635465	3.997003e-01	0.398
Rap1 signalling	R-HSA-392517	4.193039e-01	0.377
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	3.332553e-01	0.477
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	4.971901e-01	0.303
KEAP1-NFE2L2 pathway	R-HSA-9755511	3.087627e-01	0.510
The NLRP3 inflammasome	R-HSA-844456	4.193039e-01	0.377
Potential therapeutics for SARS	R-HSA-9679191	3.000795e-01	0.523
Cellular response to chemical stress	R-HSA-9711123	3.983472e-01	0.400
Signal transduction by L1	R-HSA-445144	4.449598e-01	0.352
Signaling by ALK	R-HSA-201556	3.002277e-01	0.523
Displacement of DNA glycosylase by APEX1	R-HSA-110357	2.577742e-01	0.589
The NLRP1 inflammasome	R-HSA-844455	3.881628e-01	0.411
Regulation of HMOX1 expression and activity	R-HSA-9707587	4.454317e-01	0.351
NrCAM interactions	R-HSA-447038	4.973431e-01	0.303
SMAC (DIABLO) binds to IAPs	R-HSA-111463	4.973431e-01	0.303
G1/S-Specific Transcription	R-HSA-69205	4.149781e-01	0.382
Sensory processing of sound	R-HSA-9659379	4.835659e-01	0.316
Platelet sensitization by LDL	R-HSA-432142	3.932644e-01	0.405
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	4.660309e-01	0.332
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	3.574149e-01	0.447
Inflammasomes	R-HSA-622312	4.286151e-01	0.368
Diseases of DNA repair	R-HSA-9675135	4.375024e-01	0.359
Signaling by NOTCH4	R-HSA-9013694	4.152733e-01	0.382
Nuclear events mediated by NFE2L2	R-HSA-9759194	2.594183e-01	0.586
CD28 dependent Vav1 pathway	R-HSA-389359	4.975304e-01	0.303
ChREBP activates metabolic gene expression	R-HSA-163765	3.997003e-01	0.398
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	4.333876e-01	0.363
SARS-CoV-2 Infection	R-HSA-9694516	3.443562e-01	0.463
Butyrophilin (BTN) family interactions	R-HSA-8851680	3.297615e-01	0.482
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	2.962587e-01	0.528
Signaling by Leptin	R-HSA-2586552	3.651014e-01	0.438
Assembly of Viral Components at the Budding Site	R-HSA-168316	4.973431e-01	0.303
Processing of DNA double-strand break ends	R-HSA-5693607	5.103941e-01	0.292
G0 and Early G1	R-HSA-1538133	5.129375e-01	0.290
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	5.129375e-01	0.290
FGFR2 alternative splicing	R-HSA-6803529	5.188926e-01	0.285
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	5.188926e-01	0.285
Activation of NF-kappaB in B cells	R-HSA-1169091	5.213165e-01	0.283
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	5.236483e-01	0.281
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	5.264911e-01	0.279
Degradation of GLI1 by the proteasome	R-HSA-5610780	5.264911e-01	0.279
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	5.278145e-01	0.278
Retrograde neurotrophin signalling	R-HSA-177504	5.278145e-01	0.278
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	5.278145e-01	0.278
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	5.278145e-01	0.278
CRMPs in Sema3A signaling	R-HSA-399956	5.278145e-01	0.278
Signaling by FGFR4 in disease	R-HSA-5655291	5.278145e-01	0.278
NRIF signals cell death from the nucleus	R-HSA-205043	5.278145e-01	0.278
Regulation of KIT signaling	R-HSA-1433559	5.278145e-01	0.278
Integrin signaling	R-HSA-354192	5.331349e-01	0.273
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	5.331349e-01	0.273
Activation of ATR in response to replication stress	R-HSA-176187	5.331349e-01	0.273
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	5.331349e-01	0.273
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	5.331349e-01	0.273
TCR signaling	R-HSA-202403	5.371833e-01	0.270
Uptake and actions of bacterial toxins	R-HSA-5339562	5.375108e-01	0.270
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	5.423321e-01	0.266
Syndecan interactions	R-HSA-3000170	5.423321e-01	0.266
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	5.442082e-01	0.264
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	5.443981e-01	0.264
Nef Mediated CD8 Down-regulation	R-HSA-182218	5.443981e-01	0.264
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	5.443981e-01	0.264
IkBA variant leads to EDA-ID	R-HSA-5603029	5.443981e-01	0.264
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	5.443981e-01	0.264
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	5.443981e-01	0.264
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	5.443981e-01	0.264
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	5.443981e-01	0.264
PKB-mediated events	R-HSA-109703	5.443981e-01	0.264
Cam-PDE 1 activation	R-HSA-111957	5.443981e-01	0.264
PDE3B signalling	R-HSA-165160	5.443981e-01	0.264
Synthesis of dolichyl-phosphate mannose	R-HSA-162699	5.443981e-01	0.264
Signalling to p38 via RIT and RIN	R-HSA-187706	5.443981e-01	0.264
Orexin and neuropeptides FF and QRFP bind to their respective receptors	R-HSA-389397	5.443981e-01	0.264
CLEC7A/inflammasome pathway	R-HSA-5660668	5.443981e-01	0.264
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	5.443981e-01	0.264
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	5.446449e-01	0.264
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	5.446449e-01	0.264
G1/S DNA Damage Checkpoints	R-HSA-69615	5.469127e-01	0.262
Vpu mediated degradation of CD4	R-HSA-180534	5.529067e-01	0.257
Meiotic synapsis	R-HSA-1221632	5.534656e-01	0.257
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	5.568346e-01	0.254
Processive synthesis on the lagging strand	R-HSA-69183	5.568346e-01	0.254
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	5.568346e-01	0.254
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	5.568346e-01	0.254
SHC1 events in EGFR signaling	R-HSA-180336	5.568346e-01	0.254
ERBB2 Regulates Cell Motility	R-HSA-6785631	5.568346e-01	0.254
p75NTR signals via NF-kB	R-HSA-193639	5.568346e-01	0.254
Activation of BAD and translocation to mitochondria	R-HSA-111447	5.568346e-01	0.254
Formation of the anterior neural plate	R-HSA-9823739	5.568346e-01	0.254
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	5.615316e-01	0.251
Hh mutants abrogate ligand secretion	R-HSA-5387390	5.616052e-01	0.251
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	5.641786e-01	0.249
TRAF6 mediated NF-kB activation	R-HSA-933542	5.650959e-01	0.248
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	5.650959e-01	0.248
Signaling by NOTCH	R-HSA-157118	5.702166e-01	0.244
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	5.722245e-01	0.242
Signaling by NOTCH2	R-HSA-1980145	5.722245e-01	0.242
Mitophagy	R-HSA-5205647	5.722245e-01	0.242
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	5.765921e-01	0.239
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	5.765921e-01	0.239
Netrin-1 signaling	R-HSA-373752	5.786611e-01	0.238
Signaling by NOTCH1	R-HSA-1980143	5.821198e-01	0.235
tRNA processing	R-HSA-72306	5.843613e-01	0.233
WNT5A-dependent internalization of FZD4	R-HSA-5099900	5.845620e-01	0.233
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	5.845620e-01	0.233
Differentiation of T cells	R-HSA-9945266	5.845620e-01	0.233
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	5.845620e-01	0.233
Signaling by LTK in cancer	R-HSA-9842640	5.870506e-01	0.231
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	5.870506e-01	0.231
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	5.870506e-01	0.231
Erythropoietin activates STAT5	R-HSA-9027283	5.870506e-01	0.231
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	5.870506e-01	0.231
MET Receptor Activation	R-HSA-6806942	5.870506e-01	0.231
Neurofascin interactions	R-HSA-447043	5.870506e-01	0.231
Abacavir transmembrane transport	R-HSA-2161517	5.870506e-01	0.231
Regulation of NFE2L2 gene expression	R-HSA-9818749	5.870506e-01	0.231
CREB phosphorylation	R-HSA-199920	5.870506e-01	0.231
Nef and signal transduction	R-HSA-164944	5.870506e-01	0.231
HDL clearance	R-HSA-8964011	5.870506e-01	0.231
Leukotriene receptors	R-HSA-391906	5.870506e-01	0.231
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	5.870506e-01	0.231
Acyl chain remodelling of PS	R-HSA-1482801	5.871527e-01	0.231
Formation of the nephric duct	R-HSA-9830364	5.871527e-01	0.231
Glycogen breakdown (glycogenolysis)	R-HSA-70221	5.871527e-01	0.231
Oncogene Induced Senescence	R-HSA-2559585	5.910642e-01	0.228
PERK regulates gene expression	R-HSA-381042	5.910642e-01	0.228
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	5.910642e-01	0.228
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	5.910642e-01	0.228
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	5.910642e-01	0.228
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	5.950562e-01	0.225
Defective CFTR causes cystic fibrosis	R-HSA-5678895	5.953572e-01	0.225
Somitogenesis	R-HSA-9824272	5.953572e-01	0.225
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	5.953572e-01	0.225
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	5.953572e-01	0.225
Generic Transcription Pathway	R-HSA-212436	5.973172e-01	0.224
Ion homeostasis	R-HSA-5578775	5.997216e-01	0.222
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	5.997216e-01	0.222
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	6.030362e-01	0.220
CLEC7A (Dectin-1) signaling	R-HSA-5607764	6.048661e-01	0.218
Signaling by EGFR in Cancer	R-HSA-1643713	6.084783e-01	0.216
Signaling by FLT3 fusion proteins	R-HSA-9703465	6.084783e-01	0.216
TRP channels	R-HSA-3295583	6.084783e-01	0.216
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	6.084783e-01	0.216
PRC2 methylates histones and DNA	R-HSA-212300	6.094055e-01	0.215
Regulation of TP53 Degradation	R-HSA-6804757	6.094055e-01	0.215
Vif-mediated degradation of APOBEC3G	R-HSA-180585	6.094055e-01	0.215
TRAF3-dependent IRF activation pathway	R-HSA-918233	6.109843e-01	0.214
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	6.109843e-01	0.214
tRNA modification in the mitochondrion	R-HSA-6787450	6.109843e-01	0.214
Condensation of Prophase Chromosomes	R-HSA-2299718	6.116773e-01	0.213
Regulation of T cell activation by CD28 family	R-HSA-388841	6.119112e-01	0.213
ER-Phagosome pathway	R-HSA-1236974	6.243510e-01	0.205
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	6.257124e-01	0.204
MET activates PI3K/AKT signaling	R-HSA-8851907	6.257124e-01	0.204
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	6.257124e-01	0.204
TRIF-mediated programmed cell death	R-HSA-2562578	6.257124e-01	0.204
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	6.257124e-01	0.204
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	6.257124e-01	0.204
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	6.257124e-01	0.204
Nef Mediated CD4 Down-regulation	R-HSA-167590	6.257124e-01	0.204
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	6.257124e-01	0.204
Activated NTRK3 signals through PI3K	R-HSA-9603381	6.257124e-01	0.204
VLDL clearance	R-HSA-8964046	6.257124e-01	0.204
Cation-coupled Chloride cotransporters	R-HSA-426117	6.257124e-01	0.204
Regulation of PTEN localization	R-HSA-8948747	6.257124e-01	0.204
Maturation of replicase proteins	R-HSA-9694301	6.257124e-01	0.204
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	6.272318e-01	0.203
Degradation of AXIN	R-HSA-4641257	6.272318e-01	0.203
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	6.272318e-01	0.203
Signaling by Nuclear Receptors	R-HSA-9006931	6.284273e-01	0.202
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	6.290552e-01	0.201
Insulin processing	R-HSA-264876	6.290552e-01	0.201
Dual incision in TC-NER	R-HSA-6782135	6.290752e-01	0.201
Antigen processing-Cross presentation	R-HSA-1236975	6.310058e-01	0.200
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	6.310058e-01	0.200
Signaling by MET	R-HSA-6806834	6.335363e-01	0.198
PI3K events in ERBB2 signaling	R-HSA-1963642	6.361030e-01	0.196
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	6.361030e-01	0.196
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	6.361030e-01	0.196
Elevation of cytosolic Ca2+ levels	R-HSA-139853	6.361030e-01	0.196
Glycogen storage diseases	R-HSA-3229121	6.361030e-01	0.196
Regulation of NPAS4 gene expression	R-HSA-9768759	6.361030e-01	0.196
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	6.361030e-01	0.196
Specification of primordial germ cells	R-HSA-9827857	6.361030e-01	0.196
MyD88 dependent cascade initiated on endosome	R-HSA-975155	6.416114e-01	0.193
Intraflagellar transport	R-HSA-5620924	6.431361e-01	0.192
Regulation of beta-cell development	R-HSA-186712	6.432722e-01	0.192
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	6.458287e-01	0.190
Telomere Extension By Telomerase	R-HSA-171319	6.488721e-01	0.188
Phase 0 - rapid depolarisation	R-HSA-5576892	6.488721e-01	0.188
Sphingolipid de novo biosynthesis	R-HSA-1660661	6.571375e-01	0.182
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	6.571375e-01	0.182
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	6.571375e-01	0.182
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	6.571375e-01	0.182
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	6.571375e-01	0.182
Signaling by NOTCH1 in Cancer	R-HSA-2644603	6.571375e-01	0.182
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	6.571537e-01	0.182
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	6.582535e-01	0.182
Signaling by Hedgehog	R-HSA-5358351	6.592032e-01	0.181
FOXO-mediated transcription of cell death genes	R-HSA-9614657	6.599304e-01	0.181
Regulation of TP53 Activity through Methylation	R-HSA-6804760	6.599304e-01	0.181
GAB1 signalosome	R-HSA-180292	6.599304e-01	0.181
PKA activation	R-HSA-163615	6.599304e-01	0.181
Apoptotic factor-mediated response	R-HSA-111471	6.599304e-01	0.181
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	6.599304e-01	0.181
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	6.599304e-01	0.181
Synaptic adhesion-like molecules	R-HSA-8849932	6.599304e-01	0.181
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	6.599304e-01	0.181
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	6.607566e-01	0.180
RSK activation	R-HSA-444257	6.607566e-01	0.180
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	6.607566e-01	0.180
EGFR interacts with phospholipase C-gamma	R-HSA-212718	6.607566e-01	0.180
phospho-PLA2 pathway	R-HSA-111995	6.607566e-01	0.180
Regulation of NPAS4 mRNA translation	R-HSA-9768778	6.607566e-01	0.180
MET receptor recycling	R-HSA-8875656	6.607566e-01	0.180
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	6.607566e-01	0.180
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	6.607566e-01	0.180
Interleukin-9 signaling	R-HSA-8985947	6.607566e-01	0.180
Axonal growth inhibition (RHOA activation)	R-HSA-193634	6.607566e-01	0.180
Regulation by c-FLIP	R-HSA-3371378	6.607566e-01	0.180
TGFBR3 PTM regulation	R-HSA-9839383	6.607566e-01	0.180
SLC-mediated bile acid transport	R-HSA-9958517	6.607566e-01	0.180
Dimerization of procaspase-8	R-HSA-69416	6.607566e-01	0.180
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	6.607566e-01	0.180
Sodium/Proton exchangers	R-HSA-425986	6.607566e-01	0.180
Adrenoceptors	R-HSA-390696	6.607566e-01	0.180
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	6.612903e-01	0.180
Plasma lipoprotein clearance	R-HSA-8964043	6.612903e-01	0.180
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	6.612903e-01	0.180
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	6.612903e-01	0.180
Signaling by Erythropoietin	R-HSA-9006335	6.679229e-01	0.175
DNA methylation	R-HSA-5334118	6.679229e-01	0.175
Late endosomal microautophagy	R-HSA-9615710	6.679229e-01	0.175
Termination of translesion DNA synthesis	R-HSA-5656169	6.679229e-01	0.175
Platelet calcium homeostasis	R-HSA-418360	6.679229e-01	0.175
Cytoprotection by HMOX1	R-HSA-9707564	6.696907e-01	0.174
Gastrulation	R-HSA-9758941	6.703910e-01	0.174
IRS-related events triggered by IGF1R	R-HSA-2428928	6.706638e-01	0.173
Signaling by TGFB family members	R-HSA-9006936	6.725448e-01	0.172
Transport to the Golgi and subsequent modification	R-HSA-948021	6.737898e-01	0.171
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	6.775057e-01	0.169
Inhibition of DNA recombination at telomere	R-HSA-9670095	6.775057e-01	0.169
Negative regulation of NOTCH4 signaling	R-HSA-9604323	6.775057e-01	0.169
Ca2+ pathway	R-HSA-4086398	6.820349e-01	0.166
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	6.823442e-01	0.166
Regulation of signaling by CBL	R-HSA-912631	6.824882e-01	0.166
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	6.824882e-01	0.166
Interleukin-37 signaling	R-HSA-9008059	6.862064e-01	0.164
Hedgehog ligand biogenesis	R-HSA-5358346	6.872260e-01	0.163
Neutrophil degranulation	R-HSA-6798695	6.897914e-01	0.161
CASP8 activity is inhibited	R-HSA-5218900	6.925215e-01	0.160
Interleukin-21 signaling	R-HSA-9020958	6.925215e-01	0.160
MASTL Facilitates Mitotic Progression	R-HSA-2465910	6.925215e-01	0.160
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	6.925215e-01	0.160
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	6.925215e-01	0.160
Activation of the AP-1 family of transcription factors	R-HSA-450341	6.925215e-01	0.160
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	6.925215e-01	0.160
p75NTR regulates axonogenesis	R-HSA-193697	6.925215e-01	0.160
mRNA Editing	R-HSA-75072	6.925215e-01	0.160
Regulation of signaling by NODAL	R-HSA-1433617	6.925215e-01	0.160
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	6.925215e-01	0.160
Regulation of NPAS4 gene transcription	R-HSA-9768777	6.925215e-01	0.160
Respiratory syncytial virus genome replication	R-HSA-9834752	6.925215e-01	0.160
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	6.925215e-01	0.160
Interleukin-1 processing	R-HSA-448706	6.925215e-01	0.160
FLT3 Signaling	R-HSA-9607240	6.931722e-01	0.159
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	6.931722e-01	0.159
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	6.958618e-01	0.157
Interleukin-1 family signaling	R-HSA-446652	6.958618e-01	0.157
Ub-specific processing proteases	R-HSA-5689880	6.985925e-01	0.156
RNA Polymerase I Promoter Escape	R-HSA-73772	7.010713e-01	0.154
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	7.036019e-01	0.153
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	7.036019e-01	0.153
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	7.037254e-01	0.153
Glycogen synthesis	R-HSA-3322077	7.038052e-01	0.153
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	7.038052e-01	0.153
Signaling by NODAL	R-HSA-1181150	7.038052e-01	0.153
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	7.082880e-01	0.150
HIV Transcription Initiation	R-HSA-167161	7.082880e-01	0.150
RNA Polymerase II Transcription Initiation	R-HSA-75953	7.082880e-01	0.150
Signaling by FGFR1 in disease	R-HSA-5655302	7.082880e-01	0.150
Degradation of CRY and PER proteins	R-HSA-9932298	7.082880e-01	0.150
Degradation of GLI2 by the proteasome	R-HSA-5610783	7.082880e-01	0.150
IGF1R signaling cascade	R-HSA-2428924	7.091567e-01	0.149
TP53 Regulates Metabolic Genes	R-HSA-5628897	7.110174e-01	0.148
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	7.143889e-01	0.146
Regulation of PTEN stability and activity	R-HSA-8948751	7.144855e-01	0.146
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	7.212810e-01	0.142
MAPK3 (ERK1) activation	R-HSA-110056	7.213139e-01	0.142
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	7.213139e-01	0.142
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	7.213139e-01	0.142
Regulation of the apoptosome activity	R-HSA-9627069	7.213139e-01	0.142
Formation of apoptosome	R-HSA-111458	7.213139e-01	0.142
Binding and entry of HIV virion	R-HSA-173107	7.213139e-01	0.142
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	7.213139e-01	0.142
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	7.213139e-01	0.142
DNA replication initiation	R-HSA-68952	7.213139e-01	0.142
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	7.213139e-01	0.142
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	7.213139e-01	0.142
Formation of intermediate mesoderm	R-HSA-9761174	7.213139e-01	0.142
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	7.213139e-01	0.142
Pexophagy	R-HSA-9664873	7.213139e-01	0.142
CASP4 inflammasome assembly	R-HSA-9948001	7.213139e-01	0.142
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	7.213139e-01	0.142
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	7.226341e-01	0.141
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	7.228539e-01	0.141
Cleavage of the damaged pyrimidine	R-HSA-110329	7.228539e-01	0.141
Depyrimidination	R-HSA-73928	7.228539e-01	0.141
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	7.239158e-01	0.140
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	7.239158e-01	0.140
PKA-mediated phosphorylation of CREB	R-HSA-111931	7.239158e-01	0.140
Zygotic genome activation (ZGA)	R-HSA-9819196	7.239158e-01	0.140
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	7.239158e-01	0.140
Signaling by TGF-beta Receptor Complex	R-HSA-170834	7.324229e-01	0.135
RNA Polymerase II Promoter Escape	R-HSA-73776	7.368725e-01	0.133
Response of Mtb to phagocytosis	R-HSA-9637690	7.368725e-01	0.133
Co-inhibition by PD-1	R-HSA-389948	7.370243e-01	0.133
Stimuli-sensing channels	R-HSA-2672351	7.396574e-01	0.131
FRS-mediated FGFR3 signaling	R-HSA-5654706	7.428591e-01	0.129
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	7.428591e-01	0.129
Signaling by NTRK3 (TRKC)	R-HSA-9034015	7.428591e-01	0.129
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	7.474116e-01	0.126
LGI-ADAM interactions	R-HSA-5682910	7.474116e-01	0.126
Interleukin-2 signaling	R-HSA-9020558	7.474116e-01	0.126
Activated NTRK3 signals through RAS	R-HSA-9034864	7.474116e-01	0.126
Ionotropic activity of kainate receptors	R-HSA-451306	7.474116e-01	0.126
vRNP Assembly	R-HSA-192905	7.474116e-01	0.126
vRNA Synthesis	R-HSA-192814	7.474116e-01	0.126
Synthesis of PI	R-HSA-1483226	7.474116e-01	0.126
RHOBTB3 ATPase cycle	R-HSA-9706019	7.474116e-01	0.126
Bicarbonate transporters	R-HSA-425381	7.474116e-01	0.126
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	7.474116e-01	0.126
SARS-CoV-2 modulates autophagy	R-HSA-9754560	7.474116e-01	0.126
Vitamin B1 (thiamin) metabolism	R-HSA-196819	7.474116e-01	0.126
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	7.474116e-01	0.126
Dissolution of Fibrin Clot	R-HSA-75205	7.474116e-01	0.126
Toll-like Receptor Cascades	R-HSA-168898	7.502064e-01	0.125
Proteasome assembly	R-HSA-9907900	7.503486e-01	0.125
Detoxification of Reactive Oxygen Species	R-HSA-3299685	7.521405e-01	0.124
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	7.597218e-01	0.119
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	7.606773e-01	0.119
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.606773e-01	0.119
FRS-mediated FGFR4 signaling	R-HSA-5654712	7.606773e-01	0.119
Notch-HLH transcription pathway	R-HSA-350054	7.606773e-01	0.119
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	7.606773e-01	0.119
Signaling by KIT in disease	R-HSA-9669938	7.606773e-01	0.119
LDL clearance	R-HSA-8964038	7.606773e-01	0.119
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	7.632884e-01	0.117
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	7.632884e-01	0.117
IRS-mediated signalling	R-HSA-112399	7.638356e-01	0.117
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	7.663362e-01	0.116
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	7.663362e-01	0.116
Signal amplification	R-HSA-392518	7.663362e-01	0.116
eNOS activation	R-HSA-203615	7.663362e-01	0.116
NOD1/2 Signaling Pathway	R-HSA-168638	7.663362e-01	0.116
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	7.710668e-01	0.113
Condensation of Prometaphase Chromosomes	R-HSA-2514853	7.710668e-01	0.113
Synthesis of diphthamide-EEF2	R-HSA-5358493	7.710668e-01	0.113
Cytochrome c-mediated apoptotic response	R-HSA-111461	7.710668e-01	0.113
Endosomal/Vacuolar pathway	R-HSA-1236977	7.710668e-01	0.113
Plasmalogen biosynthesis	R-HSA-75896	7.710668e-01	0.113
Activated NTRK2 signals through RAS	R-HSA-9026519	7.710668e-01	0.113
ERKs are inactivated	R-HSA-202670	7.710668e-01	0.113
Sensing of DNA Double Strand Breaks	R-HSA-5693548	7.710668e-01	0.113
Reduction of cytosolic Ca++ levels	R-HSA-418359	7.710668e-01	0.113
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	7.710668e-01	0.113
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	7.710668e-01	0.113
Anchoring fibril formation	R-HSA-2214320	7.710668e-01	0.113
Sodium/Calcium exchangers	R-HSA-425561	7.710668e-01	0.113
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	7.756995e-01	0.110
Interleukin receptor SHC signaling	R-HSA-912526	7.774150e-01	0.109
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	7.774150e-01	0.109
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	7.774150e-01	0.109
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	7.774150e-01	0.109
Formation of the ureteric bud	R-HSA-9830674	7.774150e-01	0.109
Growth hormone receptor signaling	R-HSA-982772	7.774150e-01	0.109
Hedgehog 'on' state	R-HSA-5632684	7.865720e-01	0.104
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	7.875912e-01	0.104
Platelet activation, signaling and aggregation	R-HSA-76002	7.921331e-01	0.101
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	7.925080e-01	0.101
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	7.925080e-01	0.101
Regulation of IFNG signaling	R-HSA-877312	7.925080e-01	0.101
Serotonin clearance from the synaptic cleft	R-HSA-380615	7.925080e-01	0.101
p75NTR recruits signalling complexes	R-HSA-209543	7.925080e-01	0.101
SHC-related events triggered by IGF1R	R-HSA-2428933	7.925080e-01	0.101
Trafficking and processing of endosomal TLR	R-HSA-1679131	7.925080e-01	0.101
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	7.925080e-01	0.101
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	7.925080e-01	0.101
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	7.925080e-01	0.101
OAS antiviral response	R-HSA-8983711	7.925080e-01	0.101
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	7.931181e-01	0.101
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	7.931181e-01	0.101
Complex III assembly	R-HSA-9865881	7.931181e-01	0.101
FLT3 signaling in disease	R-HSA-9682385	7.933608e-01	0.101
Meiosis	R-HSA-1500620	8.061664e-01	0.094
Formation of paraxial mesoderm	R-HSA-9793380	8.064470e-01	0.093
Regulation of RUNX2 expression and activity	R-HSA-8939902	8.064470e-01	0.093
FRS-mediated FGFR1 signaling	R-HSA-5654693	8.078336e-01	0.093
Tight junction interactions	R-HSA-420029	8.078336e-01	0.093
VEGFR2 mediated cell proliferation	R-HSA-5218921	8.078336e-01	0.093
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	8.085958e-01	0.092
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	8.085958e-01	0.092
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	8.085958e-01	0.092
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	8.098575e-01	0.092
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	8.119422e-01	0.090
PDH complex synthesizes acetyl-CoA from PYR	R-HSA-9861559	8.119422e-01	0.090
Platelet Adhesion to exposed collagen	R-HSA-75892	8.119422e-01	0.090
Microbial factors inhibit CASP4 activity	R-HSA-9956593	8.119422e-01	0.090
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	8.119422e-01	0.090
Reversible hydration of carbon dioxide	R-HSA-1475029	8.119422e-01	0.090
PI5P Regulates TP53 Acetylation	R-HSA-6811555	8.119422e-01	0.090
Membrane binding and targetting of GAG proteins	R-HSA-174490	8.119422e-01	0.090
Maturation of nucleoprotein	R-HSA-9683610	8.119422e-01	0.090
HCMV Late Events	R-HSA-9610379	8.129527e-01	0.090
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	8.177271e-01	0.087
PI3K Cascade	R-HSA-109704	8.202553e-01	0.086
MET activates PTK2 signaling	R-HSA-8874081	8.216088e-01	0.085
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	8.216088e-01	0.085
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	8.216088e-01	0.085
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	8.216088e-01	0.085
Mitochondrial biogenesis	R-HSA-1592230	8.264983e-01	0.083
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	8.289661e-01	0.081
Removal of the Flap Intermediate	R-HSA-69166	8.295571e-01	0.081
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	8.295571e-01	0.081
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	8.295571e-01	0.081
Hydrolysis of LPC	R-HSA-1483115	8.295571e-01	0.081
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	8.295571e-01	0.081
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.295571e-01	0.081
Non-canonical inflammasome activation	R-HSA-9686114	8.295571e-01	0.081
Signal regulatory protein family interactions	R-HSA-391160	8.295571e-01	0.081
Acyl chain remodeling of CL	R-HSA-1482798	8.295571e-01	0.081
P2Y receptors	R-HSA-417957	8.295571e-01	0.081
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	8.306362e-01	0.081
Insulin receptor signalling cascade	R-HSA-74751	8.342136e-01	0.079
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	8.344905e-01	0.079
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	8.344905e-01	0.079
Packaging Of Telomere Ends	R-HSA-171306	8.344905e-01	0.079
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	8.344905e-01	0.079
CD28 dependent PI3K/Akt signaling	R-HSA-389357	8.344905e-01	0.079
Signaling by FGFR3 in disease	R-HSA-5655332	8.344905e-01	0.079
Signaling by NTRK2 (TRKB)	R-HSA-9006115	8.344905e-01	0.079
Post-translational protein phosphorylation	R-HSA-8957275	8.378641e-01	0.077
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	8.396053e-01	0.076
HIV Transcription Elongation	R-HSA-167169	8.396053e-01	0.076
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	8.396053e-01	0.076
Nuclear signaling by ERBB4	R-HSA-1251985	8.396053e-01	0.076
Transcriptional Regulation by NPAS4	R-HSA-9634815	8.396433e-01	0.076
Negative regulation of the PI3K/AKT network	R-HSA-199418	8.411887e-01	0.075
FOXO-mediated transcription	R-HSA-9614085	8.447820e-01	0.073
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	8.455231e-01	0.073
G beta:gamma signalling through BTK	R-HSA-8964315	8.455231e-01	0.073
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	8.455231e-01	0.073
Translesion synthesis by REV1	R-HSA-110312	8.455231e-01	0.073
Telomere C-strand synthesis initiation	R-HSA-174430	8.455231e-01	0.073
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	8.455231e-01	0.073
Protein repair	R-HSA-5676934	8.455231e-01	0.073
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	8.455231e-01	0.073
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	8.455231e-01	0.073
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	8.455231e-01	0.073
Lysosphingolipid and LPA receptors	R-HSA-419408	8.455231e-01	0.073
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	8.455231e-01	0.073
Spry regulation of FGF signaling	R-HSA-1295596	8.455231e-01	0.073
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	8.455231e-01	0.073
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	8.455231e-01	0.073
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	8.465254e-01	0.072
Formation of the Early Elongation Complex	R-HSA-113418	8.465254e-01	0.072
HIV elongation arrest and recovery	R-HSA-167287	8.465254e-01	0.072
Pausing and recovery of HIV elongation	R-HSA-167290	8.465254e-01	0.072
FRS-mediated FGFR2 signaling	R-HSA-5654700	8.465254e-01	0.072
Activation of kainate receptors upon glutamate binding	R-HSA-451326	8.465254e-01	0.072
Negative regulation of FGFR3 signaling	R-HSA-5654732	8.465254e-01	0.072
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	8.465254e-01	0.072
Pyroptosis	R-HSA-5620971	8.465254e-01	0.072
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	8.496673e-01	0.071
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	8.496673e-01	0.071
ABC-family proteins mediated transport	R-HSA-382556	8.514635e-01	0.070
Base-Excision Repair, AP Site Formation	R-HSA-73929	8.572447e-01	0.067
mRNA Capping	R-HSA-72086	8.577589e-01	0.067
Downstream signaling of activated FGFR3	R-HSA-5654708	8.577589e-01	0.067
Negative regulation of FGFR4 signaling	R-HSA-5654733	8.577589e-01	0.067
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	8.591748e-01	0.066
Scavenging by Class A Receptors	R-HSA-3000480	8.591748e-01	0.066
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	8.599943e-01	0.066
Translesion synthesis by POLI	R-HSA-5656121	8.599943e-01	0.066
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	8.599943e-01	0.066
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	8.599943e-01	0.066
Class I peroxisomal membrane protein import	R-HSA-9603798	8.599943e-01	0.066
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	8.599943e-01	0.066
Induction of Cell-Cell Fusion	R-HSA-9733458	8.599943e-01	0.066
Regulation of NF-kappa B signaling	R-HSA-9758274	8.599943e-01	0.066
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	8.599943e-01	0.066
Attachment and Entry	R-HSA-9678110	8.599943e-01	0.066
Atorvastatin ADME	R-HSA-9754706	8.599943e-01	0.066
Negative regulation of FLT3	R-HSA-9706369	8.599943e-01	0.066
Virus Assembly and Release	R-HSA-168268	8.599943e-01	0.066
Signaling by FGFR2	R-HSA-5654738	8.617207e-01	0.065
Transcription of the HIV genome	R-HSA-167172	8.660781e-01	0.062
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	8.681508e-01	0.061
Cytosolic tRNA aminoacylation	R-HSA-379716	8.681508e-01	0.061
DAP12 signaling	R-HSA-2424491	8.682355e-01	0.061
Downstream signaling of activated FGFR4	R-HSA-5654716	8.682355e-01	0.061
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	8.682355e-01	0.061
GABA synthesis, release, reuptake and degradation	R-HSA-888590	8.682355e-01	0.061
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.682355e-01	0.061
Translesion synthesis by POLK	R-HSA-5655862	8.731107e-01	0.059
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	8.731107e-01	0.059
G beta:gamma signalling through CDC42	R-HSA-8964616	8.731107e-01	0.059
SHC1 events in ERBB4 signaling	R-HSA-1250347	8.731107e-01	0.059
Heme assimilation	R-HSA-9927020	8.731107e-01	0.059
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	8.731107e-01	0.059
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	8.731107e-01	0.059
Fibronectin matrix formation	R-HSA-1566977	8.731107e-01	0.059
Acetylcholine regulates insulin secretion	R-HSA-399997	8.731107e-01	0.059
Signaling by FGFR4	R-HSA-5654743	8.766180e-01	0.057
Defective pyroptosis	R-HSA-9710421	8.766180e-01	0.057
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.779985e-01	0.057
Evasion by RSV of host interferon responses	R-HSA-9833109	8.779985e-01	0.057
Molecules associated with elastic fibres	R-HSA-2129379	8.779985e-01	0.057
Downstream signal transduction	R-HSA-186763	8.779985e-01	0.057
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	8.803360e-01	0.055
Interferon gamma signaling	R-HSA-877300	8.847935e-01	0.053
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	8.849990e-01	0.053
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	8.849990e-01	0.053
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	8.849990e-01	0.053
Choline catabolism	R-HSA-6798163	8.849990e-01	0.053
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	8.870895e-01	0.052
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	8.870895e-01	0.052
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	8.875413e-01	0.052
Early SARS-CoV-2 Infection Events	R-HSA-9772572	8.875413e-01	0.052
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	8.893099e-01	0.051
Signaling by FGFR3	R-HSA-5654741	8.921158e-01	0.050
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	8.941774e-01	0.049
G-protein beta:gamma signalling	R-HSA-397795	8.955488e-01	0.048
Regulation of necroptotic cell death	R-HSA-5675482	8.955488e-01	0.048
Negative regulation of FGFR1 signaling	R-HSA-5654726	8.955488e-01	0.048
FGFR1 mutant receptor activation	R-HSA-1839124	8.955488e-01	0.048
G beta:gamma signalling through PLC beta	R-HSA-418217	8.957741e-01	0.048
Polo-like kinase mediated events	R-HSA-156711	8.957741e-01	0.048
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	8.957741e-01	0.048
Presynaptic function of Kainate receptors	R-HSA-500657	8.957741e-01	0.048
RNA Polymerase III Transcription Termination	R-HSA-73980	8.957741e-01	0.048
PKA activation in glucagon signalling	R-HSA-164378	8.957741e-01	0.048
Tie2 Signaling	R-HSA-210993	8.957741e-01	0.048
Nucleotide-like (purinergic) receptors	R-HSA-418038	8.957741e-01	0.048
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	8.991904e-01	0.046
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	8.991904e-01	0.046
tRNA Aminoacylation	R-HSA-379724	9.004670e-01	0.046
Metabolism of polyamines	R-HSA-351202	9.004670e-01	0.046
Acyl chain remodelling of PC	R-HSA-1482788	9.034148e-01	0.044
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	9.034148e-01	0.044
Effects of PIP2 hydrolysis	R-HSA-114508	9.034148e-01	0.044
Glucagon signaling in metabolic regulation	R-HSA-163359	9.034148e-01	0.044
Miscellaneous transport and binding events	R-HSA-5223345	9.034148e-01	0.044
Signaling by FGFR in disease	R-HSA-1226099	9.040984e-01	0.044
Signaling by ERBB4	R-HSA-1236394	9.040984e-01	0.044
IKK complex recruitment mediated by RIP1	R-HSA-937041	9.055401e-01	0.043
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	9.055401e-01	0.043
PI-3K cascade:FGFR3	R-HSA-5654710	9.055401e-01	0.043
Crosslinking of collagen fibrils	R-HSA-2243919	9.055401e-01	0.043
Germ layer formation at gastrulation	R-HSA-9754189	9.055401e-01	0.043
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	9.055401e-01	0.043
Signaling by FGFR2 IIIa TM	R-HSA-8851708	9.055401e-01	0.043
Pyrimidine biosynthesis	R-HSA-500753	9.055401e-01	0.043
Specification of the neural plate border	R-HSA-9834899	9.055401e-01	0.043
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	9.055401e-01	0.043
Diseases of hemostasis	R-HSA-9671793	9.055401e-01	0.043
O2/CO2 exchange in erythrocytes	R-HSA-1480926	9.055401e-01	0.043
Other interleukin signaling	R-HSA-449836	9.055401e-01	0.043
Maturation of nucleoprotein	R-HSA-9694631	9.055401e-01	0.043
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	9.055401e-01	0.043
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	9.058440e-01	0.043
Synthesis of PC	R-HSA-1483191	9.058440e-01	0.043
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.096310e-01	0.041
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.107244e-01	0.041
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.107244e-01	0.041
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	9.107244e-01	0.041
Negative regulation of FGFR2 signaling	R-HSA-5654727	9.107244e-01	0.041
NPAS4 regulates expression of target genes	R-HSA-9768919	9.107244e-01	0.041
Adaptive Immune System	R-HSA-1280218	9.130659e-01	0.039
Regulation of PD-L1(CD274) translation	R-HSA-9909620	9.143917e-01	0.039
PI-3K cascade:FGFR4	R-HSA-5654720	9.143917e-01	0.039
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	9.143917e-01	0.039
Wax and plasmalogen biosynthesis	R-HSA-8848584	9.143917e-01	0.039
Acyl chain remodelling of PI	R-HSA-1482922	9.143917e-01	0.039
Common Pathway of Fibrin Clot Formation	R-HSA-140875	9.143917e-01	0.039
Nephrin family interactions	R-HSA-373753	9.143917e-01	0.039
Eicosanoid ligand-binding receptors	R-HSA-391903	9.143917e-01	0.039
Downstream signaling of activated FGFR2	R-HSA-5654696	9.175129e-01	0.037
Downstream signaling of activated FGFR1	R-HSA-5654687	9.175129e-01	0.037
Acyl chain remodelling of PE	R-HSA-1482839	9.175129e-01	0.037
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	9.203492e-01	0.036
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.224142e-01	0.035
G-protein activation	R-HSA-202040	9.224142e-01	0.035
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	9.224142e-01	0.035
SHC-mediated cascade:FGFR3	R-HSA-5654704	9.224142e-01	0.035
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.224142e-01	0.035
Signalling to RAS	R-HSA-167044	9.224142e-01	0.035
Basigin interactions	R-HSA-210991	9.224142e-01	0.035
Acyl chain remodelling of PG	R-HSA-1482925	9.224142e-01	0.035
Ion transport by P-type ATPases	R-HSA-936837	9.224401e-01	0.035
Downstream TCR signaling	R-HSA-202424	9.224415e-01	0.035
Signaling by FGFR2 in disease	R-HSA-5655253	9.234843e-01	0.035
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	9.238136e-01	0.034
RNA Polymerase III Transcription	R-HSA-74158	9.238136e-01	0.034
Lysosome Vesicle Biogenesis	R-HSA-432720	9.238136e-01	0.034
Glycosphingolipid transport	R-HSA-9845576	9.238136e-01	0.034
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.238136e-01	0.034
ABC transporter disorders	R-HSA-5619084	9.238824e-01	0.034
Infectious disease	R-HSA-5663205	9.272208e-01	0.033
Transmission across Chemical Synapses	R-HSA-112315	9.280535e-01	0.032
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.282252e-01	0.032
TRAF6 mediated IRF7 activation	R-HSA-933541	9.296583e-01	0.032
Cleavage of the damaged purine	R-HSA-110331	9.296583e-01	0.032
SLC-mediated transport of organic cations	R-HSA-549127	9.296583e-01	0.032
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	9.296854e-01	0.032
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.296854e-01	0.032
SHC-mediated cascade:FGFR4	R-HSA-5654719	9.296854e-01	0.032
Molybdenum cofactor biosynthesis	R-HSA-947581	9.296854e-01	0.032
Attachment and Entry	R-HSA-9694614	9.296854e-01	0.032
Assembly Of The HIV Virion	R-HSA-175474	9.296854e-01	0.032
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.301224e-01	0.031
C-type lectin receptors (CLRs)	R-HSA-5621481	9.313964e-01	0.031
Signaling by Insulin receptor	R-HSA-74752	9.342903e-01	0.030
RIPK1-mediated regulated necrosis	R-HSA-5213460	9.350772e-01	0.029
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.350772e-01	0.029
Elastic fibre formation	R-HSA-1566948	9.350772e-01	0.029
Depurination	R-HSA-73927	9.350772e-01	0.029
SLC-mediated transport of inorganic anions	R-HSA-9958790	9.350772e-01	0.029
Kidney development	R-HSA-9830369	9.359494e-01	0.029
PI-3K cascade:FGFR1	R-HSA-5654689	9.362755e-01	0.029
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	9.362755e-01	0.029
RAF-independent MAPK1/3 activation	R-HSA-112409	9.362755e-01	0.029
Nucleotide biosynthesis	R-HSA-8956320	9.380481e-01	0.028
Regulated Necrosis	R-HSA-5218859	9.399543e-01	0.027
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.400987e-01	0.027
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.400987e-01	0.027
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	9.412701e-01	0.026
Regulation of PTEN mRNA translation	R-HSA-8943723	9.422483e-01	0.026
Organic anion transport by SLCO transporters	R-HSA-879518	9.422483e-01	0.026
Carnitine shuttle	R-HSA-200425	9.422483e-01	0.026
Interleukin-20 family signaling	R-HSA-8854691	9.422483e-01	0.026
Platelet homeostasis	R-HSA-418346	9.433165e-01	0.025
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.434675e-01	0.025
Interleukin-2 family signaling	R-HSA-451927	9.447496e-01	0.025
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.447496e-01	0.025
Diseases of Immune System	R-HSA-5260271	9.447496e-01	0.025
Diseases associated with the TLR signaling cascade	R-HSA-5602358	9.447496e-01	0.025
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.447496e-01	0.025
G alpha (z) signalling events	R-HSA-418597	9.462848e-01	0.024
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.472871e-01	0.024
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.476616e-01	0.023
Thromboxane signalling through TP receptor	R-HSA-428930	9.476616e-01	0.023
SHC-mediated cascade:FGFR1	R-HSA-5654688	9.476616e-01	0.023
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	9.476616e-01	0.023
TNFs bind their physiological receptors	R-HSA-5669034	9.476616e-01	0.023
Reproduction	R-HSA-1474165	9.484102e-01	0.023
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.490553e-01	0.023
Signaling by FGFR1	R-HSA-5654736	9.500100e-01	0.022
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	9.525678e-01	0.021
G protein gated Potassium channels	R-HSA-1296059	9.525678e-01	0.021
Activation of G protein gated Potassium channels	R-HSA-1296041	9.525678e-01	0.021
PI-3K cascade:FGFR2	R-HSA-5654695	9.525678e-01	0.021
Defects in cobalamin (B12) metabolism	R-HSA-3296469	9.525678e-01	0.021
Beta-oxidation of pristanoyl-CoA	R-HSA-389887	9.525678e-01	0.021
Hyaluronan degradation	R-HSA-2160916	9.525678e-01	0.021
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	9.525678e-01	0.021
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.525678e-01	0.021
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.525678e-01	0.021
Laminin interactions	R-HSA-3000157	9.525678e-01	0.021
Synthesis of PA	R-HSA-1483166	9.534931e-01	0.021
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.537907e-01	0.021
Signaling by FGFR	R-HSA-190236	9.559074e-01	0.020
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.567250e-01	0.019
Metalloprotease DUBs	R-HSA-5689901	9.570144e-01	0.019
Linoleic acid (LA) metabolism	R-HSA-2046105	9.570144e-01	0.019
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.570144e-01	0.019
Abacavir ADME	R-HSA-2161522	9.570144e-01	0.019
Signaling by SCF-KIT	R-HSA-1433557	9.601324e-01	0.018
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	9.601324e-01	0.018
Cobalamin (Cbl) metabolism	R-HSA-9759218	9.610443e-01	0.017
SHC-mediated cascade:FGFR2	R-HSA-5654699	9.610443e-01	0.017
RNA Polymerase I Promoter Opening	R-HSA-73728	9.610443e-01	0.017
Cristae formation	R-HSA-8949613	9.610443e-01	0.017
Signaling by BMP	R-HSA-201451	9.610443e-01	0.017
Triglyceride biosynthesis	R-HSA-75109	9.610443e-01	0.017
Synthesis of PE	R-HSA-1483213	9.610443e-01	0.017
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.621704e-01	0.017
DAP12 interactions	R-HSA-2172127	9.632815e-01	0.016
Amine ligand-binding receptors	R-HSA-375280	9.632815e-01	0.016
Integration of energy metabolism	R-HSA-163685	9.637934e-01	0.016
Prednisone ADME	R-HSA-9757110	9.646967e-01	0.016
Insulin receptor recycling	R-HSA-77387	9.646967e-01	0.016
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.654731e-01	0.015
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.656171e-01	0.015
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.661908e-01	0.015
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.661908e-01	0.015
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.669486e-01	0.015
Pre-NOTCH Transcription and Translation	R-HSA-1912408	9.676215e-01	0.014
Mitochondrial protein import	R-HSA-1268020	9.677496e-01	0.014
NCAM signaling for neurite out-growth	R-HSA-375165	9.677496e-01	0.014
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	9.677496e-01	0.014
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	9.680068e-01	0.014
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.680068e-01	0.014
Glucagon-type ligand receptors	R-HSA-420092	9.680068e-01	0.014
Ion channel transport	R-HSA-983712	9.688136e-01	0.014
Regulation of pyruvate metabolism	R-HSA-9861718	9.688776e-01	0.014
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.688776e-01	0.014
Nuclear Receptor transcription pathway	R-HSA-383280	9.691210e-01	0.014
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	9.700545e-01	0.013
RNA Polymerase III Transcription Initiation	R-HSA-76046	9.710067e-01	0.013
Neurotransmitter clearance	R-HSA-112311	9.710067e-01	0.013
Neuronal System	R-HSA-112316	9.713230e-01	0.013
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.713580e-01	0.013
SLC transporter disorders	R-HSA-5619102	9.728037e-01	0.012
GPER1 signaling	R-HSA-9634597	9.736471e-01	0.012
Metal ion SLC transporters	R-HSA-425410	9.736471e-01	0.012
Budding and maturation of HIV virion	R-HSA-162588	9.737255e-01	0.012
Cargo concentration in the ER	R-HSA-5694530	9.737255e-01	0.012
Amyloid fiber formation	R-HSA-977225	9.748640e-01	0.011
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.760689e-01	0.011
Inwardly rectifying K+ channels	R-HSA-1296065	9.761895e-01	0.010
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.784226e-01	0.009
Assembly of the ORC complex at the origin of replication	R-HSA-68616	9.784226e-01	0.009
Meiotic recombination	R-HSA-912446	9.795023e-01	0.009
Cytosolic sulfonation of small molecules	R-HSA-156584	9.795023e-01	0.009
The phototransduction cascade	R-HSA-2514856	9.795023e-01	0.009
Immune System	R-HSA-168256	9.810478e-01	0.008
Regulation of insulin secretion	R-HSA-422356	9.819103e-01	0.008
Calnexin/calreticulin cycle	R-HSA-901042	9.822804e-01	0.008
Hyaluronan metabolism	R-HSA-2142845	9.822804e-01	0.008
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.822804e-01	0.008
COPII-mediated vesicle transport	R-HSA-204005	9.823206e-01	0.008
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.834723e-01	0.007
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.839425e-01	0.007
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.839459e-01	0.007
GPVI-mediated activation cascade	R-HSA-114604	9.854488e-01	0.006
FGFR2 mutant receptor activation	R-HSA-1839126	9.854488e-01	0.006
Protein localization	R-HSA-9609507	9.862596e-01	0.006
Hemostasis	R-HSA-109582	9.866078e-01	0.006
SIRT1 negatively regulates rRNA expression	R-HSA-427359	9.868139e-01	0.006
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.868139e-01	0.006
Collagen chain trimerization	R-HSA-8948216	9.868139e-01	0.006
Metabolism of folate and pterines	R-HSA-196757	9.868139e-01	0.006
Interferon alpha/beta signaling	R-HSA-909733	9.869981e-01	0.006
PPARA activates gene expression	R-HSA-1989781	9.877205e-01	0.005
Disorders of transmembrane transporters	R-HSA-5619115	9.878193e-01	0.005
Neddylation	R-HSA-8951664	9.879195e-01	0.005
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	9.886698e-01	0.005
Activation of HOX genes during differentiation	R-HSA-5619507	9.886698e-01	0.005
RSV-host interactions	R-HSA-9833110	9.886698e-01	0.005
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.890359e-01	0.005
RAS processing	R-HSA-9648002	9.891721e-01	0.005
Peroxisomal protein import	R-HSA-9033241	9.896063e-01	0.005
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.899850e-01	0.004
RAB geranylgeranylation	R-HSA-8873719	9.904601e-01	0.004
Integrin cell surface interactions	R-HSA-216083	9.904647e-01	0.004
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.906856e-01	0.004
Maturation of spike protein	R-HSA-9694548	9.911087e-01	0.004
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	9.911818e-01	0.004
Aquaporin-mediated transport	R-HSA-445717	9.912453e-01	0.004
Collagen formation	R-HSA-1474290	9.913392e-01	0.004
Intra-Golgi traffic	R-HSA-6811438	9.919431e-01	0.004
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.919431e-01	0.004
Translation of Structural Proteins	R-HSA-9683701	9.919431e-01	0.004
Signaling by PDGF	R-HSA-186797	9.919672e-01	0.004
Activation of GABAB receptors	R-HSA-991365	9.926992e-01	0.003
GABA B receptor activation	R-HSA-977444	9.926992e-01	0.003
Synthesis of very long-chain fatty acyl-CoAs	R-HSA-75876	9.933844e-01	0.003
Pre-NOTCH Expression and Processing	R-HSA-1912422	9.938971e-01	0.003
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.940053e-01	0.003
Surfactant metabolism	R-HSA-5683826	9.940053e-01	0.003
Fanconi Anemia Pathway	R-HSA-6783310	9.945680e-01	0.002
G alpha (q) signalling events	R-HSA-416476	9.946174e-01	0.002
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.946992e-01	0.002
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.953904e-01	0.002
PI Metabolism	R-HSA-1483255	9.955436e-01	0.002
Pyruvate metabolism	R-HSA-70268	9.956765e-01	0.002
Peptide hormone metabolism	R-HSA-2980736	9.959987e-01	0.002
Cardiac conduction	R-HSA-5576891	9.960195e-01	0.002
Glycerophospholipid biosynthesis	R-HSA-1483206	9.962264e-01	0.002
ECM proteoglycans	R-HSA-3000178	9.963227e-01	0.002
Metabolism of cofactors	R-HSA-8978934	9.963227e-01	0.002
Chemokine receptors bind chemokines	R-HSA-380108	9.963381e-01	0.002
Neurotransmitter release cycle	R-HSA-112310	9.966021e-01	0.001
Azathioprine ADME	R-HSA-9748787	9.966819e-01	0.001
Diseases of carbohydrate metabolism	R-HSA-5663084	9.969136e-01	0.001
Complex IV assembly	R-HSA-9864848	9.969934e-01	0.001
ROS and RNS production in phagocytes	R-HSA-1222556	9.971729e-01	0.001
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.973337e-01	0.001
Citric acid cycle (TCA cycle)	R-HSA-71403	9.974108e-01	0.001
Disease	R-HSA-1643685	9.975089e-01	0.001
Amino acids regulate mTORC1	R-HSA-9639288	9.975316e-01	0.001
Formation of the cornified envelope	R-HSA-6809371	9.975765e-01	0.001
Parasitic Infection Pathways	R-HSA-9824443	9.977310e-01	0.001
Leishmania infection	R-HSA-9658195	9.977310e-01	0.001
Post-translational protein modification	R-HSA-597592	9.977346e-01	0.001
Translation of Structural Proteins	R-HSA-9694635	9.978290e-01	0.001
Parasite infection	R-HSA-9664407	9.979955e-01	0.001
Leishmania phagocytosis	R-HSA-9664417	9.979955e-01	0.001
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.979955e-01	0.001
SLC-mediated transport of organic anions	R-HSA-9955298	9.980124e-01	0.001
Interleukin-10 signaling	R-HSA-6783783	9.980124e-01	0.001
FCERI mediated NF-kB activation	R-HSA-2871837	9.985870e-01	0.001
Amino acid transport across the plasma membrane	R-HSA-352230	9.986342e-01	0.001
Triglyceride metabolism	R-HSA-8979227	9.986342e-01	0.001
Role of phospholipids in phagocytosis	R-HSA-2029485	9.986832e-01	0.001
GABA receptor activation	R-HSA-977443	9.987625e-01	0.001
Signaling by Retinoic Acid	R-HSA-5362517	9.987625e-01	0.001
Peroxisomal lipid metabolism	R-HSA-390918	9.988322e-01	0.001
Collagen degradation	R-HSA-1442490	9.988787e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.990763e-01	0.000
Complex I biogenesis	R-HSA-6799198	9.990795e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.991753e-01	0.000
Asparagine N-linked glycosylation	R-HSA-446203	9.991973e-01	0.000
Extracellular matrix organization	R-HSA-1474244	9.993035e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.993750e-01	0.000
SLC-mediated transport of amino acids	R-HSA-9958863	9.993798e-01	0.000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.993798e-01	0.000
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.994381e-01	0.000
Metabolism of proteins	R-HSA-392499	9.994401e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.994862e-01	0.000
Phospholipid metabolism	R-HSA-1483257	9.995095e-01	0.000
Glycosphingolipid catabolism	R-HSA-9840310	9.995387e-01	0.000
FCERI mediated MAPK activation	R-HSA-2871796	9.995672e-01	0.000
Metal ion assimilation from the host	R-HSA-9638482	9.995821e-01	0.000
Purine catabolism	R-HSA-74259	9.996214e-01	0.000
Innate Immune System	R-HSA-168249	9.996845e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.996900e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.997059e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.997680e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.997839e-01	0.000
Cholesterol biosynthesis	R-HSA-191273	9.997906e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.999221e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999272e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999289e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999526e-01	0.000
G alpha (s) signalling events	R-HSA-418555	9.999538e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999606e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.999606e-01	0.000
FCGR activation	R-HSA-2029481	9.999610e-01	0.000
Mitochondrial protein degradation	R-HSA-9837999	9.999647e-01	0.000
Scavenging of heme from plasma	R-HSA-2168880	9.999710e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999735e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.999737e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.999737e-01	0.000
Potassium Channels	R-HSA-1296071	9.999737e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.999784e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.999816e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999869e-01	0.000
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999892e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999934e-01	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	9.999951e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.999955e-01	0.000
Keratinization	R-HSA-6805567	9.999975e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999985e-01	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999987e-01	0.000
Glycosphingolipid metabolism	R-HSA-1660662	9.999987e-01	0.000
Bacterial Infection Pathways	R-HSA-9824439	9.999988e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999991e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.999993e-01	0.000
Sensory perception of taste	R-HSA-9717189	9.999995e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999995e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.999998e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999999e-01	0.000
Arachidonate metabolism	R-HSA-2142753	9.999999e-01	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000
Drug ADME	R-HSA-9748784	1.000000e+00	0.000
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Metabolism of steroids	R-HSA-8957322	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000