PHKG1

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
O60841 S222 Sugiyama EIF5B IF2 KIAA0741 KNQKNKPGPNIEsGNEDDDAsFKIKTVAQKKAEKKERERKK
O75569 S18 Sugiyama PRKRA PACT RAX HSD-14 HSD14 ___MSQSRHRAEAPPLEREDsGtFsLGKMITAKPGKTPIQV
O75937 S81 Sugiyama DNAJC8 SPF31 HSPC315 HSPC331 VLQIDPEVTDEEIKKRFRQLsILVHPDKNQDDADRAQKAFE
O95714 S2928 Sugiyama HERC2 ILLGRIRAEEEDLAAVPFLAsDNEEEEDEKGNSGsLIRKKA
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04406 S312 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 sstFDAGAGIALNDHFVKLIsWyDNEFGysNRVVDLMAHMA
P04406 S321 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IALNDHFVKLIsWyDNEFGysNRVVDLMAHMAsKE______
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P06737 S15 SIGNOR PYGL ______MAKPLTDQEKRRQIsIRGIVGVENVAELKKSFNRH
P06899 S39 Sugiyama H2BC11 H2BFR HIST1H2BJ VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07437 S75 Sugiyama TUBB TUBB5 OK/SW-cl.56 tGGKyVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
P07900 S52 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0DPH7 S48 Sugiyama TUBA3C TUBA2 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P10412 S55 Sugiyama H1-4 H1F4 HIST1H1E AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P10636 S554 SIGNOR|EPSD MAPT MAPTL MTBT1 TAU tPPTREPKKVAVVRtPPKsPssAKSRLQTAPVPMPDLKNVK
P10636 S579 SIGNOR|EPSD MAPT MAPTL MTBT1 TAU RLQTAPVPMPDLKNVKsKIGstENLKHQPGGGKVQIINKKL
P10636 S602 SIGNOR MAPT MAPTL MTBT1 TAU NLKHQPGGGKVQIINKKLDLsNVQsKCGsKDNIKHVPGGGs
P10636 S622 SIGNOR MAPT MAPTL MTBT1 TAU sNVQsKCGsKDNIKHVPGGGsVQIVyKPVDLSKVTsKCGsL
P10636 S669 SIGNOR MAPT MAPTL MTBT1 TAU PGGGQVEVKSEKLDFKDRVQsKIGsLDNITHVPGGGNKKIE
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11217 S15 SIGNOR PYGM ______MsRPLSDQEKRKQIsVRGLAGVENVtELKKNFNRH
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14618 T50 Sugiyama PKM OIP3 PK2 PK3 PKM2 MCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMIKsGMN
P14625 S514 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK
P15735 S35 Sugiyama PHKG2 AAAKEFYQKYDPKDVIGRGVssVVRRCVHRATGHEFAVKIM
P15735 S36 Sugiyama PHKG2 AAKEFYQKYDPKDVIGRGVssVVRRCVHRATGHEFAVKIME
P16070 S71 Sugiyama CD44 LHR MDU2 MDU3 MIC4 DLCKAFNSTLPTMAQMEKALsIGFEtCRyGFIEGHVVIPRI
P16402 S56 Sugiyama H1-3 H1F3 HIST1H1D AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403 S55 Sugiyama H1-2 H1F2 HIST1H1C AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P20618 S162 Sugiyama PSMB1 PSC5 DEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLLDNQVG
P23527 S39 Sugiyama H2BC17 H2BFH H2BFN HIST1H2BO VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA
P23588 S122 Sugiyama EIF4B NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373 S97 Sugiyama RPL13 BBC1 OK/SW-cl.46 sLEELRVAGIHKKVARTIGIsVDPRRRNKstEsLQANVQRL
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P29692 S44 Sugiyama EEF1D EF1D RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P30050 S138 Sugiyama RPL12 HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30101 T485 Sugiyama PDIA3 ERP57 ERP60 GRP58 KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P31327 S205 Sugiyama CPS1 FEGQPVDFVDPNKQNLIAEVstKDVKVYGKGNPTKVVAVDC
P32119 T142 Sugiyama PRDX2 NKEFB TDPX1 EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P33778 S39 Sugiyama H2BC3 H2BFF HIST1H2BB ITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISSKA
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P35579 S1916 Sugiyama MYH9 LQRELEDAtEtADAMNREVssLKNKLRRGDLPFVVPRRMAR
P35579 T1906 Sugiyama MYH9 AQRANAsRRKLQRELEDAtEtADAMNREVssLKNKLRRGDL
P37108 S25 Sugiyama SRP14 EsEQFLtELTRLFQKCRTSGsVyItLKKYDGRTKPIPKKGt
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646 T116 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P42677 S78 Sugiyama RPS27 MPS1 GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46777 S172 Sugiyama RPL5 MSTP030 RTTTGNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNA
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P50552 S46 Sugiyama VASP AGTGPQAFSRVQIyHNPTANsFRVVGRKMQPDQQVVINCAI
P50991 S51 Sugiyama CCT4 CCTD SRB AQIRFsNISAAKAVADAIRtsLGPKGMDKMIQDGKGDVtIt
P53999 S118 Sugiyama SUB1 PC4 RPO2TC1 PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 S60 Sugiyama ACTB HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P60709 T318 Sugiyama ACTB VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61604 S64 Sugiyama HSPE1 AtVVAVGsGsKGKGGEIQPVsVKVGDKVLLPEyGGtKVVLD
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62263 S139 Sugiyama RPS14 PRO2640 LARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL________
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62736 S62 Sugiyama ACTA2 ACTSA ACTVS GIG46 HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P62736 T320 Sugiyama ACTA2 ACTSA ACTVS GIG46 VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62899 T26 Sugiyama RPL31 KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62917 S14 Sugiyama RPL8 _______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P63220 S68 Sugiyama RPS21 GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 S60 Sugiyama ACTG1 ACTG HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P63261 T318 Sugiyama ACTG1 ACTG VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S61 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P63267 T319 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P67809 S209 Sugiyama YBX1 NSEP1 YB1 RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P68032 S62 Sugiyama ACTC1 ACTC HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68032 T320 Sugiyama ACTC1 ACTC VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68133 S62 Sugiyama ACTA1 ACTA HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68133 T320 Sugiyama ACTA1 ACTA VMSGGTTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68363 S48 Sugiyama TUBA1B HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P83731 S38 Sugiyama RPL24 GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P83731 S7 Sugiyama RPL24 ______________MKVELCsFsGyKIYPGHGRRYARTDGK
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098 S12 Sugiyama RPL19 _________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
P84098 S122 Sugiyama RPL19 LRRLLRRYRESKKIDRHMyHsLyLKVKGNVFKNKRILMEHI
Q06830 T143 Sugiyama PRDX1 PAGA PAGB TDPX2 EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q07021 S210 Sugiyama C1QBP GC1QBP HABP1 SF2P32 EDEVGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDS
Q13509 S75 Sugiyama TUBB3 TUBB4 SSHKYVPRAILVDLEPGtMDsVRSGAFGHLFRPDNFIFGQS
Q13885 S75 Sugiyama TUBB2A TUBB2 AGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q14568 S52 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15084 S389 Sugiyama PDIA6 ERP5 P5 TXNDC7 FALLKGsFsEQGINEFLRELsFGRGstAPVGGGAFPtIVER
Q15185 S85 Sugiyama PTGES3 P23 TEBP KHKRtDRsILCCLRKGEsGQsWPRLTKERAKLNWLsVDFNN
Q16778 S39 Sugiyama H2BC21 H2BFQ HIST2H2BE VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIssKA
Q16816 S10 Sugiyama PHKG1 PHKG ___________MTRDEALPDsHsAQDFYENYEPKEILGRGV
Q16816 S12 Sugiyama PHKG1 PHKG _________MTRDEALPDsHsAQDFYENYEPKEILGRGVss
Q16816 S172 Sugiyama PHKG1 PHKG KPENILLDDNMNIKLTDFGFsCQLEPGERLREVCGtPSYLA
Q16816 S31 SIGNOR|EPSD|Sugiyama PHKG1 PHKG HsAQDFYENYEPKEILGRGVssVVRRCIHKPTSQEyAVKVI
Q16816 S32 Sugiyama PHKG1 PHKG sAQDFYENYEPKEILGRGVssVVRRCIHKPTSQEyAVKVID
Q16816 S381 Sugiyama PHKG1 PHKG KGQQQNRAALFENtPKAVLLsLAEEDY______________
Q16816 S58 Sugiyama PHKG1 PHKG IHKPTSQEyAVKVIDVtGGGsFSPEEVRELREATLKEVDIL
Q16816 S82 SIGNOR|EPSD PHKG1 PHKG EEVRELREATLKEVDILRKVsGHPNIIQLKDTYETNTFFFL
Q16816 T187 Sugiyama PHKG1 PHKG TDFGFsCQLEPGERLREVCGtPSYLAPEIIECSMNEDHPGy
Q16816 T374 Sugiyama PHKG1 PHKG IYGHWVKKGQQQNRAALFENtPKAVLLsLAEEDY_______
Q16816 T54 Sugiyama PHKG1 PHKG VRRCIHKPTSQEyAVKVIDVtGGGsFSPEEVRELREATLKE
Q16816 Y207 Sugiyama PHKG1 PHKG tPSYLAPEIIECSMNEDHPGyGKEVDMWSTGVIMYTLLAGS
Q16816 Y350 Sugiyama PHKG1 PHKG REIVIRDPYALRPLRRLIDAyAFRIYGHWVKKGQQQNRAAL
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q5M775 S112 Sugiyama SPECC1 CYTSB NSP5 SGTGAFTTTKRTGIPAPREFsVTVSRERsVPRGPSNPRKsV
Q6DN03 S39 Sugiyama H2BC20P HIST2H2BC VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA
Q6DRA6 S39 Sugiyama H2BC19P HIST2H2BD VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA
Q6PEY2 S48 Sugiyama TUBA3E HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q71U36 S48 Sugiyama TUBA1A TUBA3 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q71UM5 S78 Sugiyama RPS27L GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q8IWX8 S904 Sugiyama CHERP DAN26 SCAF6 KGVGVALDDPyENyRRNKsysFIARMKARDECK________
Q8N257 S39 Sugiyama H2BC26 H2BU1 HIST3H2BB VTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIssKA
Q99613 S754 Sugiyama EIF3C EIF3S8 REHVVAASKAMKMGDWKTCHsFIINEKMNGKVWDLFPEADK
Q99848 S270 Sugiyama EBNA1BP2 EBP2 FGGKKKGSKWNtREsyDDVssFRAKTAHGRGLKRPGKKGSN
Q9BQE3 S48 Sugiyama TUBA1C TUBA6 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9BVA1 S75 Sugiyama TUBB2B tGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9H788 S315 Sugiyama SH2D4A PPP1R38 SH2A LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9NZL9 S9 Sugiyama MAT2B TGR MSTP045 Nbla02999 UNQ2435/PRO4995 ____________MVGREKELsIHFVPGsCRLVEEEVNIPNR
Q9UPQ0 S377 Sugiyama LIMCH1 KIAA1102 LREEDDKWQDDLARWKSRRRsVsQDLIKKEEERKKMEKLLA
Q9UQ35 S2692 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9Y2B0 S55 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDELEWEIAQVDPKKTIQMGsFRINPDGsQsVVEVPyARsE
Q9Y3U8 S91 Sugiyama RPL36 KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Signal Transduction R-HSA-162582 1.366685e-13 12.864 0 0
Cell Cycle R-HSA-1640170 9.410961e-11 10.026 0 0
Cell Cycle Checkpoints R-HSA-69620 1.046325e-09 8.980 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.387297e-08 7.858 0 0
NRAGE signals death through JNK R-HSA-193648 3.322725e-08 7.479 0 0
Cell Cycle, Mitotic R-HSA-69278 7.348817e-08 7.134 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.094298e-07 6.961 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.094298e-07 6.961 0 0
Axon guidance R-HSA-422475 1.012986e-07 6.994 0 0
G alpha (12/13) signalling events R-HSA-416482 1.382439e-07 6.859 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 9.377516e-07 6.028 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.104117e-06 5.957 0 0
Nervous system development R-HSA-9675108 1.325262e-06 5.878 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.588881e-06 5.799 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.636000e-06 5.786 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.590703e-06 5.798 0 0
Apoptotic execution phase R-HSA-75153 2.889593e-06 5.539 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.023921e-06 5.519 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 8.495631e-06 5.071 0 0
M Phase R-HSA-68886 1.027679e-05 4.988 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.376520e-05 4.861 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.760085e-05 4.754 0 0
FOXO-mediated transcription R-HSA-9614085 2.075288e-05 4.683 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.989023e-05 4.524 0 0
Signaling by Hippo R-HSA-2028269 3.429492e-05 4.465 0 0
Apoptosis R-HSA-109581 4.464060e-05 4.350 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 6.289757e-05 4.201 0 0
Mitotic Prometaphase R-HSA-68877 6.638785e-05 4.178 0 0
Generic Transcription Pathway R-HSA-212436 9.339573e-05 4.030 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.206513e-04 3.918 0 0
Death Receptor Signaling R-HSA-73887 1.338587e-04 3.873 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.671918e-04 3.777 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.211839e-04 3.655 0 0
Metalloprotease DUBs R-HSA-5689901 2.976911e-04 3.526 0 0
Mitotic Prophase R-HSA-68875 3.291086e-04 3.483 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.406430e-04 3.468 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 4.343837e-04 3.362 0 0
Programmed Cell Death R-HSA-5357801 4.599207e-04 3.337 0 0
Oncogenic MAPK signaling R-HSA-6802957 4.921368e-04 3.308 0 0
Regulation of TP53 Activity R-HSA-5633007 5.029175e-04 3.299 0 0
RNA Polymerase II Transcription R-HSA-73857 5.333163e-04 3.273 0 0
PKMTs methylate histone lysines R-HSA-3214841 5.578664e-04 3.253 0 0
MAPK family signaling cascades R-HSA-5683057 6.330173e-04 3.199 0 0
Chromatin modifying enzymes R-HSA-3247509 6.839047e-04 3.165 0 0
Intracellular signaling by second messengers R-HSA-9006925 7.008194e-04 3.154 0 0
Cellular Senescence R-HSA-2559583 6.884742e-04 3.162 0 0
Separation of Sister Chromatids R-HSA-2467813 7.596818e-04 3.119 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 8.120724e-04 3.090 0 0
Chromatin organization R-HSA-4839726 8.431899e-04 3.074 0 0
Interleukin-37 signaling R-HSA-9008059 8.731836e-04 3.059 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 9.794653e-04 3.009 0 0
Gene expression (Transcription) R-HSA-74160 9.788536e-04 3.009 0 0
CREB phosphorylation R-HSA-199920 1.140692e-03 2.943 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 9.937439e-04 3.003 0 0
Netrin-1 signaling R-HSA-373752 1.267640e-03 2.897 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.523531e-03 2.817 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.495126e-03 2.825 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.540337e-03 2.812 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.572128e-03 2.804 0 0
G2/M Checkpoints R-HSA-69481 1.648869e-03 2.783 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.634437e-03 2.787 0 0
L1CAM interactions R-HSA-373760 1.597040e-03 2.797 0 0
EPH-Ephrin signaling R-HSA-2682334 1.724198e-03 2.763 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.759077e-03 2.755 0 0
Diseases of DNA repair R-HSA-9675135 1.843345e-03 2.734 0 0
Mitotic Anaphase R-HSA-68882 2.038326e-03 2.691 0 0
DNA methylation R-HSA-5334118 2.066888e-03 2.685 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.066888e-03 2.685 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.324372e-03 2.634 0 0
Recycling pathway of L1 R-HSA-437239 2.204705e-03 2.657 0 0
HATs acetylate histones R-HSA-3214847 2.294406e-03 2.639 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.206966e-03 2.656 0 0
Meiosis R-HSA-1500620 2.302401e-03 2.638 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.345185e-03 2.630 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.416987e-03 2.617 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.623234e-03 2.581 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.704130e-03 2.568 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.750335e-03 2.561 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.840836e-03 2.547 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.963510e-03 2.528 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.975360e-03 2.526 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.079993e-03 2.511 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.210595e-03 2.493 0 0
TRP channels R-HSA-3295583 3.046903e-03 2.516 0 0
RMTs methylate histone arginines R-HSA-3214858 3.210595e-03 2.493 0 0
PI Metabolism R-HSA-1483255 3.250956e-03 2.488 0 0
Post NMDA receptor activation events R-HSA-438064 3.369663e-03 2.472 0 0
Activation of RAC1 R-HSA-428540 3.384948e-03 2.470 0 0
DNA Repair R-HSA-73894 3.416672e-03 2.466 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.020457e-03 2.396 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 3.819373e-03 2.418 0 0
Interaction between L1 and Ankyrins R-HSA-445095 3.823342e-03 2.418 0 0
PRC2 methylates histones and DNA R-HSA-212300 3.983611e-03 2.400 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.794993e-03 2.421 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 3.958889e-03 2.402 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 3.823342e-03 2.418 0 0
FLT3 Signaling R-HSA-9607240 3.927016e-03 2.406 0 0
Diseases of programmed cell death R-HSA-9645723 3.806943e-03 2.419 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.794993e-03 2.421 0 0
Meiotic recombination R-HSA-912446 4.290929e-03 2.367 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 4.334497e-03 2.363 0 0
Signaling downstream of RAS mutants R-HSA-9649948 4.504078e-03 2.346 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 4.504078e-03 2.346 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 4.504078e-03 2.346 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 4.674270e-03 2.330 0 0
Signaling by RAS mutants R-HSA-6802949 4.504078e-03 2.346 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 4.399518e-03 2.357 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.707476e-03 2.327 0 0
Nuclear Envelope Breakdown R-HSA-2980766 4.707476e-03 2.327 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 4.779318e-03 2.321 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 4.798884e-03 2.319 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 4.833770e-03 2.316 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 4.833770e-03 2.316 0 0
Meiotic synapsis R-HSA-1221632 5.822853e-03 2.235 0 0
ESR-mediated signaling R-HSA-8939211 5.975234e-03 2.224 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 6.268730e-03 2.203 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 6.636795e-03 2.178 0 0
Homology Directed Repair R-HSA-5693538 6.774146e-03 2.169 0 0
Receptor Mediated Mitophagy R-HSA-8934903 6.805356e-03 2.167 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 6.822826e-03 2.166 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 6.848598e-03 2.164 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 6.933474e-03 2.159 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 7.555153e-03 2.122 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 7.555153e-03 2.122 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 7.555153e-03 2.122 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 7.251237e-03 2.140 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 7.043360e-03 2.152 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 7.043360e-03 2.152 0 0
HDACs deacetylate histones R-HSA-3214815 7.770025e-03 2.110 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 8.073584e-03 2.093 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 8.411812e-03 2.075 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 9.075697e-03 2.042 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 9.372514e-03 2.028 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.489078e-03 2.023 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.037330e-02 1.984 0 0
Synaptic adhesion-like molecules R-HSA-8849932 9.953877e-03 2.002 0 0
Polo-like kinase mediated events R-HSA-156711 9.953877e-03 2.002 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.047004e-02 1.980 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.055666e-02 1.976 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.069962e-02 1.971 0 0
MAP2K and MAPK activation R-HSA-5674135 1.109147e-02 1.955 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.109147e-02 1.955 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.132338e-02 1.946 0 0
Potassium Channels R-HSA-1296071 1.140253e-02 1.943 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.303987e-02 1.885 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.303987e-02 1.885 0 0
Integrin signaling R-HSA-354192 1.234241e-02 1.909 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.289621e-02 1.890 0 0
Rap1 signalling R-HSA-392517 1.256602e-02 1.901 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.192013e-02 1.924 0 0
Deubiquitination R-HSA-5688426 1.233564e-02 1.909 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.234467e-02 1.909 0 0
Neuronal System R-HSA-112316 1.349878e-02 1.870 0 0
Co-stimulation by CD28 R-HSA-389356 1.378382e-02 1.861 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.378499e-02 1.861 0 0
Depurination R-HSA-73927 1.378499e-02 1.861 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.378499e-02 1.861 0 0
Cardiac conduction R-HSA-5576891 1.464032e-02 1.834 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.490464e-02 1.827 0 0
Kinesins R-HSA-983189 1.495236e-02 1.825 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.564835e-02 1.806 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.564835e-02 1.806 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.559991e-02 1.807 0 0
Formation of definitive endoderm R-HSA-9823730 1.564835e-02 1.806 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.560852e-02 1.807 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.568008e-02 1.805 0 0
Neurodegenerative Diseases R-HSA-8863678 1.568008e-02 1.805 0 0
Developmental Biology R-HSA-1266738 1.688230e-02 1.773 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.529132e-02 1.816 0 0
DNA Double Strand Break Response R-HSA-5693606 1.714902e-02 1.766 0 0
Mitophagy R-HSA-5205647 1.715980e-02 1.765 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.715980e-02 1.765 0 0
Nuclear import of Rev protein R-HSA-180746 1.715980e-02 1.765 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.715980e-02 1.765 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.729743e-02 1.762 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.731496e-02 1.762 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.731496e-02 1.762 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.731496e-02 1.762 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.731496e-02 1.762 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.731496e-02 1.762 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.731496e-02 1.762 0 0
WNT mediated activation of DVL R-HSA-201688 1.931789e-02 1.714 0 0
ALK mutants bind TKIs R-HSA-9700645 1.931789e-02 1.714 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.890233e-02 1.723 0 0
Nucleosome assembly R-HSA-774815 1.968074e-02 1.706 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.968074e-02 1.706 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.830244e-02 1.737 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.931789e-02 1.714 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.958310e-02 1.708 0 0
Activation of BH3-only proteins R-HSA-114452 1.814615e-02 1.741 0 0
Signaling by ALK in cancer R-HSA-9700206 1.958310e-02 1.708 0 0
Signaling by ROBO receptors R-HSA-376176 1.879003e-02 1.726 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.858287e-02 1.731 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.963855e-02 1.707 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.003753e-02 1.698 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.144415e-02 1.669 0 0
Reproduction R-HSA-1474165 2.229372e-02 1.652 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.246538e-02 1.648 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.257912e-02 1.646 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 2.301835e-02 1.638 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 2.301835e-02 1.638 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 2.301835e-02 1.638 0 0
Signaling by VEGF R-HSA-194138 2.301835e-02 1.638 0 0
Signaling by NTRKs R-HSA-166520 2.325343e-02 1.634 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.344564e-02 1.630 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.458998e-02 1.609 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.606587e-02 1.584 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.674086e-02 1.573 0 0
Packaging Of Telomere Ends R-HSA-171306 2.674086e-02 1.573 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.674086e-02 1.573 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.683711e-02 1.571 0 0
Cleavage of the damaged purine R-HSA-110331 2.683711e-02 1.571 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.854938e-02 1.544 0 0
Ephrin signaling R-HSA-3928664 2.891671e-02 1.539 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.914276e-02 1.535 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.944418e-02 1.531 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.914276e-02 1.535 0 0
TBC/RABGAPs R-HSA-8854214 3.187459e-02 1.497 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.944418e-02 1.531 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.914276e-02 1.535 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 3.316992e-02 1.479 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 3.349366e-02 1.475 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 3.367963e-02 1.473 0 0
Signaling by APC mutants R-HSA-4839744 3.415656e-02 1.467 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 3.415656e-02 1.467 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 3.415656e-02 1.467 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 3.415656e-02 1.467 0 0
Ub-specific processing proteases R-HSA-5689880 3.474845e-02 1.459 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.477487e-02 1.459 0 0
The NLRP3 inflammasome R-HSA-844456 3.508311e-02 1.455 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 3.516112e-02 1.454 0 0
HCN channels R-HSA-1296061 4.157700e-02 1.381 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 3.564666e-02 1.448 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.564666e-02 1.448 0 0
RAF activation R-HSA-5673000 3.868817e-02 1.412 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.994017e-02 1.399 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 4.154058e-02 1.382 0 0
Signaling by EGFR R-HSA-177929 3.655186e-02 1.437 0 0
Chromosome Maintenance R-HSA-73886 4.135745e-02 1.383 0 0
Signal amplification R-HSA-392518 3.868817e-02 1.412 0 0
Ion homeostasis R-HSA-5578775 3.655186e-02 1.437 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.951152e-02 1.403 0 0
Dopamine receptors R-HSA-390651 4.157700e-02 1.381 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 4.157700e-02 1.381 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 3.994017e-02 1.399 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.567292e-02 1.448 0 0
Opioid Signalling R-HSA-111885 3.986005e-02 1.399 0 0
Semaphorin interactions R-HSA-373755 4.023049e-02 1.395 0 0
Cell-extracellular matrix interactions R-HSA-446353 3.564666e-02 1.448 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 3.564666e-02 1.448 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.596818e-02 1.444 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.951152e-02 1.403 0 0
ISG15 antiviral mechanism R-HSA-1169408 3.888625e-02 1.410 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 3.655186e-02 1.437 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 4.240744e-02 1.373 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 4.302079e-02 1.366 0 0
Activation of HOX genes during differentiation R-HSA-5619507 4.302079e-02 1.366 0 0
Signaling by AXIN mutants R-HSA-4839735 4.364644e-02 1.360 0 0
Signaling by AMER1 mutants R-HSA-4839748 4.364644e-02 1.360 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 4.377651e-02 1.359 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 4.418716e-02 1.355 0 0
HDMs demethylate histones R-HSA-3214842 4.621205e-02 1.335 0 0
Long-term potentiation R-HSA-9620244 4.621205e-02 1.335 0 0
Cell-Cell communication R-HSA-1500931 4.745300e-02 1.324 0 0
Glycolysis R-HSA-70171 4.810338e-02 1.318 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 4.858530e-02 1.313 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 4.876723e-02 1.312 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 4.876723e-02 1.312 0 0
Rab regulation of trafficking R-HSA-9007101 4.944935e-02 1.306 0 0
RET signaling R-HSA-8853659 5.019312e-02 1.299 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 5.045375e-02 1.297 0 0
Base Excision Repair R-HSA-73884 5.166017e-02 1.287 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 5.255526e-02 1.279 0 0
RSK activation R-HSA-444257 5.255526e-02 1.279 0 0
Formation of annular gap junctions R-HSA-196025 5.255526e-02 1.279 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 5.255526e-02 1.279 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 5.297795e-02 1.276 0 0
Gene Silencing by RNA R-HSA-211000 5.359599e-02 1.271 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 5.361389e-02 1.271 0 0
Defective Base Excision Repair Associated with OGG1 R-HSA-9656249 5.602822e-02 1.252 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 5.602822e-02 1.252 0 0
Transport of glycerol from adipocytes to the liver by Aquaporins R-HSA-432030 5.602822e-02 1.252 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 5.602822e-02 1.252 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 5.602822e-02 1.252 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 5.602822e-02 1.252 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 5.856653e-02 1.232 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 5.572661e-02 1.254 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 6.329884e-02 1.199 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 5.672012e-02 1.246 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 6.030881e-02 1.220 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 6.329884e-02 1.199 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 5.456759e-02 1.263 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 5.864059e-02 1.232 0 0
Platelet activation, signaling and aggregation R-HSA-76002 6.484605e-02 1.188 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 5.799741e-02 1.237 0 0
GPER1 signaling R-HSA-9634597 5.657981e-02 1.247 0 0
G-protein mediated events R-HSA-112040 5.864059e-02 1.232 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 5.672012e-02 1.246 0 0
Sensory processing of sound R-HSA-9659379 5.522871e-02 1.258 0 0
Defective pyroptosis R-HSA-9710421 6.351520e-02 1.197 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 5.583481e-02 1.253 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 5.692829e-02 1.245 0 0
Depyrimidination R-HSA-73928 5.692829e-02 1.245 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 6.629754e-02 1.179 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 6.692818e-02 1.174 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 6.765830e-02 1.170 0 0
ARMS-mediated activation R-HSA-170984 6.765830e-02 1.170 0 0
Gap junction degradation R-HSA-190873 6.765830e-02 1.170 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 6.765830e-02 1.170 0 0
Cytokine Signaling in Immune system R-HSA-1280215 6.777659e-02 1.169 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 6.812524e-02 1.167 0 0
mTORC1-mediated signalling R-HSA-166208 6.812524e-02 1.167 0 0
Muscle contraction R-HSA-397014 6.835310e-02 1.165 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 6.971397e-02 1.157 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 7.058293e-02 1.151 0 0
Inflammasomes R-HSA-622312 7.058293e-02 1.151 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 7.138060e-02 1.146 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 7.138060e-02 1.146 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 7.138060e-02 1.146 0 0
Effects of PIP2 hydrolysis R-HSA-114508 7.149351e-02 1.146 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 7.149351e-02 1.146 0 0
Selective autophagy R-HSA-9663891 7.279440e-02 1.138 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 9.185654e-02 1.037 0 0
Regulation of TP53 Expression R-HSA-6804754 9.185654e-02 1.037 0 0
Diseases of cellular response to stress R-HSA-9675132 9.185654e-02 1.037 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 9.185654e-02 1.037 0 0
Diseases of Cellular Senescence R-HSA-9630747 9.185654e-02 1.037 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 9.185654e-02 1.037 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 9.185654e-02 1.037 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 9.185654e-02 1.037 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 9.185654e-02 1.037 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 9.185654e-02 1.037 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 9.185654e-02 1.037 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 9.185654e-02 1.037 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 9.185654e-02 1.037 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 9.185654e-02 1.037 0 0
Potassium transport channels R-HSA-1296067 9.185654e-02 1.037 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 9.185654e-02 1.037 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 8.228858e-02 1.085 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 8.228858e-02 1.085 0 0
Signaling by MAPK mutants R-HSA-9652817 8.228858e-02 1.085 0 0
Folding of actin by CCT/TriC R-HSA-390450 8.475268e-02 1.072 0 0
Regulation of KIT signaling R-HSA-1433559 8.071372e-02 1.093 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 8.071372e-02 1.093 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 7.465474e-02 1.127 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 8.712777e-02 1.060 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 8.016635e-02 1.096 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 7.952880e-02 1.099 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 8.822736e-02 1.054 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 7.812742e-02 1.107 0 0
Estrogen-dependent gene expression R-HSA-9018519 8.399232e-02 1.076 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 7.812742e-02 1.107 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.071372e-02 1.093 0 0
Regulation of CDH11 function R-HSA-9762292 8.475268e-02 1.072 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 8.031636e-02 1.095 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 8.712777e-02 1.060 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 8.822736e-02 1.054 0 0
Signalling to ERKs R-HSA-187687 8.976928e-02 1.047 0 0
Oncogene Induced Senescence R-HSA-2559585 8.976928e-02 1.047 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 8.925707e-02 1.049 0 0
Mitotic G2-G2/M phases R-HSA-453274 7.848656e-02 1.105 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 8.016635e-02 1.096 0 0
Membrane Trafficking R-HSA-199991 7.740676e-02 1.111 0 0
Host Interactions of HIV factors R-HSA-162909 7.757634e-02 1.110 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 7.952880e-02 1.099 0 0
Stimuli-sensing channels R-HSA-2672351 8.925707e-02 1.049 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 8.616261e-02 1.065 0 0
MITF-M-dependent gene expression R-HSA-9856651 8.973739e-02 1.047 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.195728e-02 1.036 0 0
Signaling by Nuclear Receptors R-HSA-9006931 9.534516e-02 1.021 0 0
Signaling by WNT R-HSA-195721 9.544402e-02 1.020 0 0
Spry regulation of FGF signaling R-HSA-1295596 9.588878e-02 1.018 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 9.588878e-02 1.018 0 0
Translesion synthesis by REV1 R-HSA-110312 9.588878e-02 1.018 0 0
DCC mediated attractive signaling R-HSA-418885 9.588878e-02 1.018 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 9.588878e-02 1.018 0 0
Telomere Maintenance R-HSA-157579 9.811494e-02 1.008 0 0
Regulation of TP53 Degradation R-HSA-6804757 9.985024e-02 1.001 0 0
Translation initiation complex formation R-HSA-72649 9.998184e-02 1.000 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.006687e-01 0.997 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.006687e-01 0.997 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.006687e-01 0.997 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.006687e-01 0.997 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.006687e-01 0.997 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 1.006687e-01 0.997 0 0
Cell junction organization R-HSA-446728 1.011983e-01 0.995 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.032902e-01 0.986 0 0
Interleukin-2 signaling R-HSA-9020558 1.037323e-01 0.984 0 0
PECAM1 interactions R-HSA-210990 1.037323e-01 0.984 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.050505e-01 0.979 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 1.071720e-01 0.970 0 0
MTOR signalling R-HSA-165159 1.072732e-01 0.970 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.072732e-01 0.970 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.078216e-01 0.967 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.078216e-01 0.967 0 0
G alpha (z) signalling events R-HSA-418597 1.087452e-01 0.964 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.187182e-01 0.925 0 0
KIT mutants bind TKIs R-HSA-9669921 1.187182e-01 0.925 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.187182e-01 0.925 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.187182e-01 0.925 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.187182e-01 0.925 0 0
Defective OGG1 Localization R-HSA-9657050 1.187182e-01 0.925 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.187182e-01 0.925 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.187182e-01 0.925 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.187182e-01 0.925 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.187182e-01 0.925 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.187182e-01 0.925 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.187182e-01 0.925 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.187182e-01 0.925 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.187182e-01 0.925 0 0
Defective OGG1 Substrate Binding R-HSA-9656255 1.187182e-01 0.925 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.187182e-01 0.925 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.324839e-01 0.878 0 0
Axonal growth stimulation R-HSA-209563 1.324839e-01 0.878 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 1.324839e-01 0.878 0 0
Invadopodia formation R-HSA-8941237 1.324839e-01 0.878 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.345687e-01 0.871 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.345687e-01 0.871 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 1.345687e-01 0.871 0 0
Translesion synthesis by POLI R-HSA-5656121 1.123991e-01 0.949 0 0
Phase 4 - resting membrane potential R-HSA-5576886 1.123991e-01 0.949 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.467763e-01 0.833 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.467763e-01 0.833 0 0
Leading Strand Synthesis R-HSA-69109 1.467763e-01 0.833 0 0
Polymerase switching R-HSA-69091 1.467763e-01 0.833 0 0
Translesion synthesis by POLK R-HSA-5655862 1.301740e-01 0.885 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.308212e-01 0.883 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.289551e-01 0.890 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.436047e-01 0.843 0 0
Voltage gated Potassium channels R-HSA-1296072 1.105534e-01 0.956 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.445363e-01 0.840 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.333389e-01 0.875 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.389163e-01 0.857 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.257651e-01 0.900 0 0
DNA Damage Bypass R-HSA-73893 1.131964e-01 0.946 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.368582e-01 0.864 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.338003e-01 0.874 0 0
Pyroptosis R-HSA-5620971 1.436047e-01 0.843 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.376262e-01 0.861 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.132966e-01 0.946 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.431386e-01 0.844 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.217560e-01 0.915 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.244603e-01 0.905 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.123991e-01 0.949 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.338891e-01 0.873 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.257651e-01 0.900 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.324839e-01 0.878 0 0
Cardiogenesis R-HSA-9733709 1.257651e-01 0.900 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.376095e-01 0.861 0 0
Neurexins and neuroligins R-HSA-6794361 1.445363e-01 0.840 0 0
G2/M Transition R-HSA-69275 1.354458e-01 0.868 0 0
Signaling by LTK R-HSA-9842663 1.467763e-01 0.833 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 1.463274e-01 0.835 0 0
DAG and IP3 signaling R-HSA-1489509 1.398789e-01 0.854 0 0
Interleukin-2 family signaling R-HSA-451927 1.462818e-01 0.835 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.430533e-01 0.845 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.430533e-01 0.845 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 1.345687e-01 0.871 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 1.168453e-01 0.932 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 1.345687e-01 0.871 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 1.324839e-01 0.878 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 1.324839e-01 0.878 0 0
Signaling by Interleukins R-HSA-449147 1.113636e-01 0.953 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.291226e-01 0.889 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.473025e-01 0.832 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.479571e-01 0.830 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.479571e-01 0.830 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 1.491289e-01 0.826 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.517200e-01 0.819 0 0
Signaling by TGFBR3 R-HSA-9839373 1.517817e-01 0.819 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.527253e-01 0.816 0 0
MHC class II antigen presentation R-HSA-2132295 1.557641e-01 0.808 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.557641e-01 0.808 0 0
Signaling by ERBB2 R-HSA-1227986 1.589697e-01 0.799 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.590095e-01 0.799 0 0
DARPP-32 events R-HSA-180024 1.590095e-01 0.799 0 0
Platelet calcium homeostasis R-HSA-418360 1.590095e-01 0.799 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.593419e-01 0.798 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.593419e-01 0.798 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.593419e-01 0.798 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 2.233486e-01 0.651 0 0
Defective OGG1 Substrate Processing R-HSA-9656256 2.233486e-01 0.651 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.233486e-01 0.651 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.233486e-01 0.651 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.233486e-01 0.651 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.233486e-01 0.651 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.233486e-01 0.651 0 0
Defective SLC26A4 causes Pendred syndrome (PDS) R-HSA-5619046 2.233486e-01 0.651 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.233486e-01 0.651 0 0
Defective SLC2A10 causes arterial tortuosity syndrome (ATS) R-HSA-5619068 2.233486e-01 0.651 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 2.233486e-01 0.651 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.233486e-01 0.651 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.233486e-01 0.651 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 2.233486e-01 0.651 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.233486e-01 0.651 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.233486e-01 0.651 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.233486e-01 0.651 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.233486e-01 0.651 0 0
NADE modulates death signalling R-HSA-205025 1.762671e-01 0.754 0 0
TNFR1-mediated ceramide production R-HSA-5626978 1.762671e-01 0.754 0 0
ATP sensitive Potassium channels R-HSA-1296025 1.762671e-01 0.754 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.762671e-01 0.754 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.762671e-01 0.754 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.762671e-01 0.754 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 1.762671e-01 0.754 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 1.762671e-01 0.754 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 1.762671e-01 0.754 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.762671e-01 0.754 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.218850e-01 0.654 0 0
IRS activation R-HSA-74713 2.218850e-01 0.654 0 0
G2 Phase R-HSA-68911 2.218850e-01 0.654 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.218850e-01 0.654 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 2.218850e-01 0.654 0 0
Type I hemidesmosome assembly R-HSA-446107 1.640680e-01 0.785 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.640680e-01 0.785 0 0
FGFR1b ligand binding and activation R-HSA-190370 1.640680e-01 0.785 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.952576e-01 0.709 0 0
Formation of axial mesoderm R-HSA-9796292 1.705034e-01 0.768 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.705034e-01 0.768 0 0
Signal attenuation R-HSA-74749 2.277374e-01 0.643 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.277374e-01 0.643 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 2.277374e-01 0.643 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.214342e-01 0.655 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.829824e-01 0.738 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 1.829824e-01 0.738 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.120701e-01 0.674 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.751269e-01 0.757 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.019666e-01 0.695 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 2.347067e-01 0.629 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 2.347067e-01 0.629 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.925510e-01 0.715 0 0
mRNA 3'-end processing R-HSA-72187 2.327951e-01 0.633 0 0
Metabolism of non-coding RNA R-HSA-194441 2.326608e-01 0.633 0 0
snRNP Assembly R-HSA-191859 2.326608e-01 0.633 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.309102e-01 0.637 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.935394e-01 0.713 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.849679e-01 0.733 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.019666e-01 0.695 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.019666e-01 0.695 0 0
Adipogenesis R-HSA-9843745 1.782421e-01 0.749 0 0
Specification of the neural plate border R-HSA-9834899 1.901852e-01 0.721 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 2.272630e-01 0.643 0 0
Signaling by FGFR3 R-HSA-5654741 2.321799e-01 0.634 0 0
Signaling by FGFR4 R-HSA-5654743 2.016530e-01 0.695 0 0
Lagging Strand Synthesis R-HSA-69186 2.347067e-01 0.629 0 0
TGFBR3 expression R-HSA-9839394 2.019666e-01 0.695 0 0
Activation of GABAB receptors R-HSA-991365 1.870547e-01 0.728 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.121830e-01 0.673 0 0
Developmental Cell Lineages R-HSA-9734767 1.659280e-01 0.780 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.925510e-01 0.715 0 0
Myogenesis R-HSA-525793 2.216282e-01 0.654 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 2.216282e-01 0.654 0 0
Germ layer formation at gastrulation R-HSA-9754189 1.901852e-01 0.721 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 1.762671e-01 0.754 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 2.418889e-01 0.616 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.272630e-01 0.643 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.952576e-01 0.709 0 0
GABA B receptor activation R-HSA-977444 1.870547e-01 0.728 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 1.731980e-01 0.761 0 0
Translesion Synthesis by POLH R-HSA-110320 1.901852e-01 0.721 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 1.647506e-01 0.783 0 0
Integration of energy metabolism R-HSA-163685 2.292137e-01 0.640 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 1.640680e-01 0.785 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 2.064173e-01 0.685 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 1.705034e-01 0.768 0 0
Apoptotic factor-mediated response R-HSA-111471 1.691676e-01 0.772 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.218850e-01 0.654 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 2.321799e-01 0.634 0 0
Signaling by TGFB family members R-HSA-9006936 1.949703e-01 0.710 0 0
Transmission across Chemical Synapses R-HSA-112315 2.116479e-01 0.674 0 0
GPVI-mediated activation cascade R-HSA-114604 1.821972e-01 0.739 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 1.705034e-01 0.768 0 0
Signaling by WNT in cancer R-HSA-4791275 2.093065e-01 0.679 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.218850e-01 0.654 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.214342e-01 0.655 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 2.046376e-01 0.689 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 2.019666e-01 0.695 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.272630e-01 0.643 0 0
ERK/MAPK targets R-HSA-198753 2.347067e-01 0.629 0 0
tRNA processing in the nucleus R-HSA-6784531 1.818882e-01 0.740 0 0
Calmodulin induced events R-HSA-111933 1.821972e-01 0.739 0 0
CaM pathway R-HSA-111997 1.821972e-01 0.739 0 0
Cell-cell junction organization R-HSA-421270 2.278426e-01 0.642 0 0
Adherens junctions interactions R-HSA-418990 2.052191e-01 0.688 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.233486e-01 0.651 0 0
Inhibition of PKR R-HSA-169131 2.233486e-01 0.651 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 1.762671e-01 0.754 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.218850e-01 0.654 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.218850e-01 0.654 0 0
Co-stimulation by ICOS R-HSA-9927354 1.640680e-01 0.785 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 1.952576e-01 0.709 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.705034e-01 0.768 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.705034e-01 0.768 0 0
cGMP effects R-HSA-418457 1.954538e-01 0.709 0 0
UCH proteinases R-HSA-5689603 1.838709e-01 0.735 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.242766e-01 0.649 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.277374e-01 0.643 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.242766e-01 0.649 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.242766e-01 0.649 0 0
Formation of the nephric duct R-HSA-9830364 2.019666e-01 0.695 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.640680e-01 0.785 0 0
Signal regulatory protein family interactions R-HSA-391160 1.954538e-01 0.709 0 0
G-protein beta:gamma signalling R-HSA-397795 2.272630e-01 0.643 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.321799e-01 0.634 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.277374e-01 0.643 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.946238e-01 0.711 0 0
Tandem pore domain potassium channels R-HSA-1296346 2.277374e-01 0.643 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 2.418889e-01 0.616 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.430954e-01 0.614 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 2.218850e-01 0.654 0 0
NrCAM interactions R-HSA-447038 2.218850e-01 0.654 0 0
Glucose metabolism R-HSA-70326 1.640931e-01 0.785 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.901852e-01 0.721 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.214342e-01 0.655 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.457222e-01 0.610 0 0
RAB geranylgeranylation R-HSA-8873719 2.467007e-01 0.608 0 0
Diseases of Immune System R-HSA-5260271 2.475326e-01 0.606 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 2.475326e-01 0.606 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 2.480415e-01 0.605 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.482506e-01 0.605 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.482506e-01 0.605 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 2.482506e-01 0.605 0 0
Prolonged ERK activation events R-HSA-169893 2.482506e-01 0.605 0 0
Killing mechanisms R-HSA-9664420 2.482506e-01 0.605 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 2.482506e-01 0.605 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 2.482506e-01 0.605 0 0
Negative regulation of FLT3 R-HSA-9706369 2.482506e-01 0.605 0 0
Interleukin-1 family signaling R-HSA-446652 2.499389e-01 0.602 0 0
Signaling by NOTCH R-HSA-157118 2.554301e-01 0.593 0 0
Centrosome maturation R-HSA-380287 2.565023e-01 0.591 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 2.579767e-01 0.588 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.579767e-01 0.588 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 2.579767e-01 0.588 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.579767e-01 0.588 0 0
Regulated Necrosis R-HSA-5218859 2.588796e-01 0.587 0 0
PLC beta mediated events R-HSA-112043 2.610362e-01 0.583 0 0
ChREBP activates metabolic gene expression R-HSA-163765 2.611288e-01 0.583 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 2.611288e-01 0.583 0 0
Synthesis of PI R-HSA-1483226 2.611288e-01 0.583 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 3.155620e-01 0.501 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.155620e-01 0.501 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.155620e-01 0.501 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 3.155620e-01 0.501 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 3.155620e-01 0.501 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.155620e-01 0.501 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 3.155620e-01 0.501 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 3.155620e-01 0.501 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.155620e-01 0.501 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.155620e-01 0.501 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 3.155620e-01 0.501 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.155620e-01 0.501 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.155620e-01 0.501 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 3.155620e-01 0.501 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 3.155620e-01 0.501 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.155620e-01 0.501 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 3.155620e-01 0.501 0 0
Defective SLC12A3 causes Gitelman syndrome (GS) R-HSA-5619087 3.155620e-01 0.501 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.155620e-01 0.501 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 3.155620e-01 0.501 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.155620e-01 0.501 0 0
MPS IIID - Sanfilippo syndrome D R-HSA-2206305 3.155620e-01 0.501 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.155620e-01 0.501 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.155620e-01 0.501 0 0
Intestinal infectious diseases R-HSA-8942233 3.155620e-01 0.501 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 2.682857e-01 0.571 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 2.682857e-01 0.571 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 2.682857e-01 0.571 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.682857e-01 0.571 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 2.682857e-01 0.571 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 3.968315e-01 0.401 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 3.968315e-01 0.401 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.968315e-01 0.401 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 3.968315e-01 0.401 0 0
Defective visual phototransduction due to STRA6 loss of function R-HSA-9918449 3.968315e-01 0.401 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 3.968315e-01 0.401 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 3.146407e-01 0.502 0 0
STAT5 Activation R-HSA-9645135 3.146407e-01 0.502 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.146407e-01 0.502 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 2.950813e-01 0.530 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.950813e-01 0.530 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.603072e-01 0.443 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.603072e-01 0.443 0 0
Disinhibition of SNARE formation R-HSA-114516 3.603072e-01 0.443 0 0
Recycling of eIF2:GDP R-HSA-72731 3.603072e-01 0.443 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.603072e-01 0.443 0 0
The IPAF inflammasome R-HSA-844623 4.684553e-01 0.329 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 4.684553e-01 0.329 0 0
Classical Kir channels R-HSA-1296053 4.684553e-01 0.329 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 4.684553e-01 0.329 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.684553e-01 0.329 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.684553e-01 0.329 0 0
MET activates PTPN11 R-HSA-8865999 4.684553e-01 0.329 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 3.292766e-01 0.482 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 3.292766e-01 0.482 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.036333e-01 0.518 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 4.047955e-01 0.393 0 0
Activation of RAS in B cells R-HSA-1169092 4.047955e-01 0.393 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 4.047955e-01 0.393 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 4.047955e-01 0.393 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.634297e-01 0.440 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.318382e-01 0.479 0 0
PKA activation R-HSA-163615 3.318382e-01 0.479 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.059453e-01 0.514 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.059453e-01 0.514 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 2.646252e-01 0.577 0 0
Thromboxane signalling through TP receptor R-HSA-428930 3.304122e-01 0.481 0 0
Deadenylation of mRNA R-HSA-429947 3.304122e-01 0.481 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 4.477418e-01 0.349 0 0
Regulated proteolysis of p75NTR R-HSA-193692 4.477418e-01 0.349 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 4.477418e-01 0.349 0 0
CASP8 activity is inhibited R-HSA-5218900 4.477418e-01 0.349 0 0
EGFR downregulation R-HSA-182971 3.272997e-01 0.485 0 0
Trafficking of AMPA receptors R-HSA-399719 3.272997e-01 0.485 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 4.306419e-01 0.366 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 3.797605e-01 0.420 0 0
Regulation of RAS by GAPs R-HSA-5658442 3.146287e-01 0.502 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.867890e-01 0.542 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.714952e-01 0.430 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 4.165569e-01 0.380 0 0
2-LTR circle formation R-HSA-164843 4.888850e-01 0.311 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 4.888850e-01 0.311 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 4.888850e-01 0.311 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.636798e-01 0.439 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 2.880096e-01 0.541 0 0
Striated Muscle Contraction R-HSA-390522 3.936937e-01 0.405 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 4.443612e-01 0.352 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 4.443612e-01 0.352 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 4.289874e-01 0.368 0 0
mRNA Splicing R-HSA-72172 2.664058e-01 0.574 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 4.246046e-01 0.372 0 0
Notch-HLH transcription pathway R-HSA-350054 4.717461e-01 0.326 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 4.951102e-01 0.305 0 0
Phase 2 - plateau phase R-HSA-5576893 4.951102e-01 0.305 0 0
G1/S-Specific Transcription R-HSA-69205 4.598501e-01 0.337 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.773744e-01 0.321 0 0
DAP12 signaling R-HSA-2424491 4.773744e-01 0.321 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.773744e-01 0.321 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 3.586190e-01 0.445 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 4.012433e-01 0.397 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 4.012433e-01 0.397 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 5.010591e-01 0.300 0 0
HCMV Early Events R-HSA-9609690 3.874486e-01 0.412 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.536348e-01 0.343 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 4.566277e-01 0.340 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 5.248682e-01 0.280 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 5.248682e-01 0.280 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 5.248682e-01 0.280 0 0
PKR-mediated signaling R-HSA-9833482 3.243373e-01 0.489 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 4.533265e-01 0.344 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 4.773744e-01 0.321 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 2.827213e-01 0.549 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.682615e-01 0.571 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 3.318382e-01 0.479 0 0
p75NTR signals via NF-kB R-HSA-193639 4.306419e-01 0.366 0 0
Signaling by SCF-KIT R-HSA-1433557 3.190992e-01 0.496 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 3.036333e-01 0.518 0 0
Extension of Telomeres R-HSA-180786 4.724947e-01 0.326 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 2.757119e-01 0.560 0 0
Termination of translesion DNA synthesis R-HSA-5656169 2.838839e-01 0.547 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 4.477418e-01 0.349 0 0
G0 and Early G1 R-HSA-1538133 3.493390e-01 0.457 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 3.939084e-01 0.405 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 4.246046e-01 0.372 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 4.316049e-01 0.365 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 4.824507e-01 0.317 0 0
IGF1R signaling cascade R-HSA-2428924 3.055622e-01 0.515 0 0
p75NTR regulates axonogenesis R-HSA-193697 4.477418e-01 0.349 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 3.035211e-01 0.518 0 0
Signaling by FGFR1 R-HSA-5654736 2.941164e-01 0.531 0 0
Inwardly rectifying K+ channels R-HSA-1296065 3.493390e-01 0.457 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 4.951102e-01 0.305 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 4.047955e-01 0.393 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 3.550525e-01 0.450 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 3.797605e-01 0.420 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.888850e-01 0.311 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.243420e-01 0.280 0 0
GAB1 signalosome R-HSA-180292 3.318382e-01 0.479 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 4.951102e-01 0.305 0 0
Formation of lateral plate mesoderm R-HSA-9758920 2.682857e-01 0.571 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.603072e-01 0.443 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 3.972904e-01 0.401 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.477418e-01 0.349 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.493390e-01 0.457 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 4.306419e-01 0.366 0 0
Signalling to RAS R-HSA-167044 4.165569e-01 0.380 0 0
Peptide chain elongation R-HSA-156902 3.457569e-01 0.461 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 5.029651e-01 0.298 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 3.208231e-01 0.494 0 0
GPCR downstream signalling R-HSA-388396 2.993654e-01 0.524 0 0
Mismatch Repair R-HSA-5358508 3.318382e-01 0.479 0 0
G1 Phase R-HSA-69236 3.376153e-01 0.472 0 0
Cyclin D associated events in G1 R-HSA-69231 3.376153e-01 0.472 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.146407e-01 0.502 0 0
Passive transport by Aquaporins R-HSA-432047 2.757119e-01 0.560 0 0
Regulation by c-FLIP R-HSA-3371378 4.047955e-01 0.393 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 4.477418e-01 0.349 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 4.165569e-01 0.380 0 0
GABA receptor activation R-HSA-977443 3.590786e-01 0.445 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 2.817620e-01 0.550 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 4.307433e-01 0.366 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 3.797605e-01 0.420 0 0
DNA Replication Pre-Initiation R-HSA-69002 4.618290e-01 0.336 0 0
Regulation of TNFR1 signaling R-HSA-5357905 5.239898e-01 0.281 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 5.243420e-01 0.280 0 0
Macroautophagy R-HSA-1632852 3.530882e-01 0.452 0 0
Regulation of insulin secretion R-HSA-422356 4.056236e-01 0.392 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.975860e-01 0.526 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.975860e-01 0.526 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.625753e-01 0.581 0 0
S Phase R-HSA-69242 3.572908e-01 0.447 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 4.047955e-01 0.393 0 0
Dimerization of procaspase-8 R-HSA-69416 4.047955e-01 0.393 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 4.047955e-01 0.393 0 0
FGFR1c ligand binding and activation R-HSA-190373 3.634297e-01 0.440 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 3.972904e-01 0.401 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 3.243373e-01 0.489 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.590786e-01 0.445 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 4.158635e-01 0.381 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.773744e-01 0.321 0 0
DNA strand elongation R-HSA-69190 5.243160e-01 0.280 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 4.606059e-01 0.337 0 0
Autophagy R-HSA-9612973 4.426928e-01 0.354 0 0
Signaling by Hedgehog R-HSA-5358351 4.930670e-01 0.307 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 2.757119e-01 0.560 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.054549e-01 0.515 0 0
Leishmania infection R-HSA-9658195 5.246974e-01 0.280 0 0
Parasitic Infection Pathways R-HSA-9824443 5.246974e-01 0.280 0 0
PERK regulates gene expression R-HSA-381042 2.839118e-01 0.547 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 3.797605e-01 0.420 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.807818e-01 0.552 0 0
HIV Life Cycle R-HSA-162587 3.715604e-01 0.430 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.262325e-01 0.486 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.840201e-01 0.416 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 2.682857e-01 0.571 0 0
CRMPs in Sema3A signaling R-HSA-399956 3.972904e-01 0.401 0 0
p38MAPK events R-HSA-171007 4.306419e-01 0.366 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.714952e-01 0.430 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 4.888850e-01 0.311 0 0
HIV Infection R-HSA-162906 3.976633e-01 0.400 0 0
Eukaryotic Translation Termination R-HSA-72764 4.705089e-01 0.327 0 0
Signaling by NOTCH1 R-HSA-1980143 3.748069e-01 0.426 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 5.248682e-01 0.280 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 4.263797e-01 0.370 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 3.146407e-01 0.502 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.838839e-01 0.547 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 3.936937e-01 0.405 0 0
RNA Polymerase I Transcription R-HSA-73864 4.049563e-01 0.393 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 3.750661e-01 0.426 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 3.750661e-01 0.426 0 0
mRNA Editing R-HSA-75072 4.477418e-01 0.349 0 0
Metabolism of RNA R-HSA-8953854 3.663592e-01 0.436 0 0
Frs2-mediated activation R-HSA-170968 3.634297e-01 0.440 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 4.717461e-01 0.326 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.155620e-01 0.501 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.682857e-01 0.571 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 2.682857e-01 0.571 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.968315e-01 0.401 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 3.968315e-01 0.401 0 0
C6 deamination of adenosine R-HSA-75102 3.968315e-01 0.401 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.968315e-01 0.401 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.603072e-01 0.443 0 0
Regulation of PTEN localization R-HSA-8948747 3.603072e-01 0.443 0 0
Netrin mediated repulsion signals R-HSA-418886 3.603072e-01 0.443 0 0
MET interacts with TNS proteins R-HSA-8875513 4.684553e-01 0.329 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 4.047955e-01 0.393 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 4.047955e-01 0.393 0 0
FLT3 signaling in disease R-HSA-9682385 3.035211e-01 0.518 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 4.306419e-01 0.366 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 3.155364e-01 0.501 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.756496e-01 0.425 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 3.748069e-01 0.426 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.815445e-01 0.317 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 5.248682e-01 0.280 0 0
Early Phase of HIV Life Cycle R-HSA-162594 4.165569e-01 0.380 0 0
Ca-dependent events R-HSA-111996 3.007853e-01 0.522 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 3.272179e-01 0.485 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.089671e-01 0.388 0 0
Signaling by PTK6 R-HSA-8848021 4.089671e-01 0.388 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 5.132800e-01 0.290 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 3.618034e-01 0.442 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 3.272179e-01 0.485 0 0
Interferon Signaling R-HSA-913531 5.224418e-01 0.282 0 0
Amyloid fiber formation R-HSA-977225 3.384091e-01 0.471 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 3.618034e-01 0.442 0 0
Cellular response to heat stress R-HSA-3371556 4.418247e-01 0.355 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 4.477418e-01 0.349 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.148411e-01 0.382 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 4.618290e-01 0.336 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.254514e-01 0.371 0 0
Hemostasis R-HSA-109582 3.837436e-01 0.416 0 0
NCAM signaling for neurite out-growth R-HSA-375165 5.241611e-01 0.281 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 4.047955e-01 0.393 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 2.838839e-01 0.547 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 4.044366e-01 0.393 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 4.289874e-01 0.368 0 0
Selenocysteine synthesis R-HSA-2408557 4.459253e-01 0.351 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 4.404026e-01 0.356 0 0
Lipid particle organization R-HSA-8964572 3.146407e-01 0.502 0 0
Nef and signal transduction R-HSA-164944 3.146407e-01 0.502 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 3.603072e-01 0.443 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 3.036333e-01 0.518 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.059453e-01 0.514 0 0
Interleukin-1 processing R-HSA-448706 4.477418e-01 0.349 0 0
Protein hydroxylation R-HSA-9629569 3.884476e-01 0.411 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 3.055622e-01 0.515 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 5.132800e-01 0.290 0 0
Nephrin family interactions R-HSA-373753 3.884476e-01 0.411 0 0
Pexophagy R-HSA-9664873 4.888850e-01 0.311 0 0
Ion channel transport R-HSA-983712 3.226024e-01 0.491 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.304122e-01 0.481 0 0
SARS-CoV-2-host interactions R-HSA-9705683 4.769505e-01 0.322 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.747700e-01 0.324 0 0
Interleukin-15 signaling R-HSA-8983432 3.292766e-01 0.482 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.747700e-01 0.324 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 3.272179e-01 0.485 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 5.125503e-01 0.290 0 0
Ca2+ activated K+ channels R-HSA-1296052 3.603072e-01 0.443 0 0
Maturation of nucleoprotein R-HSA-9683610 3.634297e-01 0.440 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 3.318382e-01 0.479 0 0
Activation of SMO R-HSA-5635838 4.632998e-01 0.334 0 0
Regulation of gene expression in beta cells R-HSA-210745 4.533265e-01 0.344 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 4.717461e-01 0.326 0 0
Disorders of Developmental Biology R-HSA-9675151 4.951102e-01 0.305 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 4.488573e-01 0.348 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.071081e-01 0.295 0 0
Platelet homeostasis R-HSA-418346 4.228764e-01 0.374 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 3.054549e-01 0.515 0 0
Downstream signal transduction R-HSA-186763 5.010591e-01 0.300 0 0
Amine ligand-binding receptors R-HSA-375280 3.376153e-01 0.472 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.146407e-01 0.502 0 0
Histamine receptors R-HSA-390650 4.684553e-01 0.329 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.319285e-01 0.365 0 0
Syndecan interactions R-HSA-3000170 4.986110e-01 0.302 0 0
Diseases of Base Excision Repair R-HSA-9605308 2.682857e-01 0.571 0 0
Phospholipid metabolism R-HSA-1483257 5.094080e-01 0.293 0 0
NTRK3 as a dependence receptor R-HSA-9603505 3.155620e-01 0.501 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.968315e-01 0.401 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 4.684553e-01 0.329 0 0
Adrenoceptors R-HSA-390696 4.047955e-01 0.393 0 0
Interleukin-18 signaling R-HSA-9012546 4.047955e-01 0.393 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 3.492755e-01 0.457 0 0
Platelet sensitization by LDL R-HSA-432142 3.318382e-01 0.479 0 0
Signaling by ALK R-HSA-201556 5.240619e-01 0.281 0 0
Specification of primordial germ cells R-HSA-9827857 3.036333e-01 0.518 0 0
Signaling by Leptin R-HSA-2586552 4.888850e-01 0.311 0 0
Mitochondrial calcium ion transport R-HSA-8949215 4.443612e-01 0.352 0 0
Influenza Infection R-HSA-168255 3.005049e-01 0.522 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.318382e-01 0.479 0 0
SARS-CoV-1 Infection R-HSA-9678108 3.333883e-01 0.477 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.714952e-01 0.430 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 4.158635e-01 0.381 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 4.423158e-01 0.354 0 0
Interleukin-12 signaling R-HSA-9020591 4.936833e-01 0.307 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 5.259476e-01 0.279 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 5.259476e-01 0.279 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 5.259476e-01 0.279 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 5.259476e-01 0.279 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 5.259476e-01 0.279 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 5.280480e-01 0.277 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 5.280480e-01 0.277 0 0
FGFR2b ligand binding and activation R-HSA-190377 5.280480e-01 0.277 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 5.280480e-01 0.277 0 0
LGI-ADAM interactions R-HSA-5682910 5.280480e-01 0.277 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 5.280480e-01 0.277 0 0
Formation of the posterior neural plate R-HSA-9832991 5.280480e-01 0.277 0 0
Bicarbonate transporters R-HSA-425381 5.280480e-01 0.277 0 0
Ionotropic activity of kainate receptors R-HSA-451306 5.280480e-01 0.277 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 5.280480e-01 0.277 0 0
Prostanoid ligand receptors R-HSA-391908 5.280480e-01 0.277 0 0
G alpha (s) signalling events R-HSA-418555 5.285343e-01 0.277 0 0
MTF1 activates gene expression R-HSA-5660489 5.315777e-01 0.274 0 0
Regulation of gap junction activity R-HSA-191650 5.315777e-01 0.274 0 0
Sensory perception of sour taste R-HSA-9729555 5.315777e-01 0.274 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 5.315777e-01 0.274 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 5.315777e-01 0.274 0 0
HCMV Late Events R-HSA-9610379 5.386275e-01 0.269 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 5.388174e-01 0.269 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 5.410095e-01 0.267 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 5.410095e-01 0.267 0 0
Signaling by NOTCH3 R-HSA-9012852 5.419251e-01 0.266 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 5.447895e-01 0.264 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 5.447895e-01 0.264 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 5.447895e-01 0.264 0 0
Generation of second messenger molecules R-HSA-202433 5.447895e-01 0.264 0 0
Regulation of necroptotic cell death R-HSA-5675482 5.470878e-01 0.262 0 0
Late Phase of HIV Life Cycle R-HSA-162599 5.496926e-01 0.260 0 0
Tight junction interactions R-HSA-420029 5.504430e-01 0.259 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 5.504430e-01 0.259 1 1
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 5.504430e-01 0.259 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.510639e-01 0.259 0 0
Signaling by FGFR2 R-HSA-5654738 5.548259e-01 0.256 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 5.548259e-01 0.256 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 5.548259e-01 0.256 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 5.557122e-01 0.255 0 0
PKA activation in glucagon signalling R-HSA-164378 5.557122e-01 0.255 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 5.557122e-01 0.255 0 0
FGFR1 ligand binding and activation R-HSA-190242 5.557122e-01 0.255 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 5.557122e-01 0.255 0 0
Tie2 Signaling R-HSA-210993 5.557122e-01 0.255 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 5.557122e-01 0.255 0 0
Insulin receptor signalling cascade R-HSA-74751 5.576288e-01 0.254 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.595437e-01 0.252 0 0
TNF signaling R-HSA-75893 5.595437e-01 0.252 0 0
NGF-stimulated transcription R-HSA-9031628 5.619658e-01 0.250 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 5.651209e-01 0.248 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.651209e-01 0.248 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 5.651209e-01 0.248 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 5.651209e-01 0.248 0 0
Integration of provirus R-HSA-162592 5.651209e-01 0.248 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 5.651209e-01 0.248 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 5.651209e-01 0.248 0 0
NF-kB is activated and signals survival R-HSA-209560 5.651209e-01 0.248 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 5.651209e-01 0.248 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 5.651209e-01 0.248 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 5.651209e-01 0.248 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 5.651209e-01 0.248 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 5.651209e-01 0.248 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 5.666154e-01 0.247 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 5.693243e-01 0.245 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 5.696806e-01 0.244 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 5.710706e-01 0.243 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 5.752726e-01 0.240 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 5.752726e-01 0.240 0 0
Regulation of CDH1 Function R-HSA-9764561 5.768654e-01 0.239 0 0
Viral mRNA Translation R-HSA-192823 5.784673e-01 0.238 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 5.801484e-01 0.236 0 0
DNA Replication R-HSA-69306 5.817302e-01 0.235 0 0
Ribosome-associated quality control R-HSA-9948299 5.837982e-01 0.234 0 0
Regulation of signaling by CBL R-HSA-912631 5.843277e-01 0.233 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 5.843277e-01 0.233 0 0
Maturation of nucleoprotein R-HSA-9694631 5.843277e-01 0.233 0 0
Signaling by FGFR1 in disease R-HSA-5655302 5.849788e-01 0.233 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.872074e-01 0.231 0 0
Activation of AMPA receptors R-HSA-399710 5.872074e-01 0.231 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 5.872074e-01 0.231 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.872074e-01 0.231 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 5.872074e-01 0.231 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.872074e-01 0.231 0 0
Activation of AKT2 R-HSA-165158 5.872074e-01 0.231 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.872074e-01 0.231 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.872074e-01 0.231 0 0
Suppression of autophagy R-HSA-9636569 5.872074e-01 0.231 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.872074e-01 0.231 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.872074e-01 0.231 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 5.872074e-01 0.231 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.872074e-01 0.231 0 0
Co-inhibition by BTLA R-HSA-9927353 5.872074e-01 0.231 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.872074e-01 0.231 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 5.872074e-01 0.231 0 0
AURKA Activation by TPX2 R-HSA-8854518 5.900913e-01 0.229 0 0
Dual Incision in GG-NER R-HSA-5696400 5.909822e-01 0.228 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 5.909822e-01 0.228 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 5.938663e-01 0.226 0 0
Dual incision in TC-NER R-HSA-6782135 5.938663e-01 0.226 0 0
PI3K Cascade R-HSA-109704 5.985111e-01 0.223 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 5.993058e-01 0.222 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.993058e-01 0.222 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 5.993058e-01 0.222 0 0
p75NTR recruits signalling complexes R-HSA-209543 6.000477e-01 0.222 0 0
VLDLR internalisation and degradation R-HSA-8866427 6.000477e-01 0.222 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 6.000477e-01 0.222 0 0
Repression of WNT target genes R-HSA-4641265 6.000477e-01 0.222 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 6.000477e-01 0.222 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 6.000477e-01 0.222 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 6.000477e-01 0.222 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 6.000477e-01 0.222 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 6.000477e-01 0.222 0 0
Pervasive developmental disorders R-HSA-9005895 6.000477e-01 0.222 0 0
Disorders of Nervous System Development R-HSA-9697154 6.000477e-01 0.222 0 0
OAS antiviral response R-HSA-8983711 6.000477e-01 0.222 0 0
Inositol phosphate metabolism R-HSA-1483249 6.018274e-01 0.221 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 6.043727e-01 0.219 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.105252e-01 0.214 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 6.117386e-01 0.213 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 6.117386e-01 0.213 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 6.120251e-01 0.213 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 6.120251e-01 0.213 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 6.120251e-01 0.213 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 6.129436e-01 0.213 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 6.225018e-01 0.206 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 6.232616e-01 0.205 0 0
Cellular responses to stimuli R-HSA-8953897 6.249691e-01 0.204 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 6.268229e-01 0.203 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 6.268229e-01 0.203 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 6.268229e-01 0.203 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 6.268229e-01 0.203 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 6.268229e-01 0.203 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.268840e-01 0.203 0 0
Signaling by GPCR R-HSA-372790 6.272306e-01 0.203 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 6.313459e-01 0.200 0 0
RUNX2 regulates bone development R-HSA-8941326 6.324228e-01 0.199 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 6.328154e-01 0.199 0 0
CD28 dependent Vav1 pathway R-HSA-389359 6.328154e-01 0.199 0 0
Adenylate cyclase activating pathway R-HSA-170660 6.328154e-01 0.199 0 0
FGFR2c ligand binding and activation R-HSA-190375 6.328154e-01 0.199 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 6.328154e-01 0.199 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 6.328154e-01 0.199 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 6.328154e-01 0.199 0 0
FGFR4 ligand binding and activation R-HSA-190322 6.328154e-01 0.199 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 6.328154e-01 0.199 0 0
FGFR3 mutant receptor activation R-HSA-2033514 6.328154e-01 0.199 0 0
Interleukin-6 signaling R-HSA-1059683 6.328154e-01 0.199 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 6.328154e-01 0.199 0 0
Cellular response to starvation R-HSA-9711097 6.334036e-01 0.198 0 0
TRAIL signaling R-HSA-75158 6.362334e-01 0.196 0 0
PDE3B signalling R-HSA-165160 6.362334e-01 0.196 0 0
PKB-mediated events R-HSA-109703 6.362334e-01 0.196 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.362334e-01 0.196 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.362334e-01 0.196 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.362334e-01 0.196 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 6.362334e-01 0.196 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.362334e-01 0.196 0 0
Signaling by MST1 R-HSA-8852405 6.362334e-01 0.196 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 6.362334e-01 0.196 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.362334e-01 0.196 0 0
NGF-independant TRKA activation R-HSA-187024 6.362334e-01 0.196 0 0
Ceramide signalling R-HSA-193681 6.362334e-01 0.196 0 0
Phosphorylation of Emi1 R-HSA-176417 6.362334e-01 0.196 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.362334e-01 0.196 0 0
Formation of the Editosome R-HSA-75094 6.362334e-01 0.196 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 6.362334e-01 0.196 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.362334e-01 0.196 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 6.362334e-01 0.196 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.362334e-01 0.196 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 6.362334e-01 0.196 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 6.362334e-01 0.196 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.362334e-01 0.196 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 6.379081e-01 0.195 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 6.379081e-01 0.195 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 6.379081e-01 0.195 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.379081e-01 0.195 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 6.379081e-01 0.195 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 6.411733e-01 0.193 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 6.427426e-01 0.192 0 0
Aquaporin-mediated transport R-HSA-445717 6.427426e-01 0.192 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 6.427426e-01 0.192 0 0
MAP kinase activation R-HSA-450294 6.427426e-01 0.192 0 0
Toll-like Receptor Cascades R-HSA-168898 6.447607e-01 0.191 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.448298e-01 0.191 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 6.448298e-01 0.191 0 0
Signaling by Erythropoietin R-HSA-9006335 6.448298e-01 0.191 0 0
Hedgehog 'off' state R-HSA-5610787 6.449316e-01 0.190 0 0
Clathrin-mediated endocytosis R-HSA-8856828 6.482300e-01 0.188 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 6.491646e-01 0.188 0 0
Co-inhibition by PD-1 R-HSA-389948 6.518807e-01 0.186 0 0
Degradation of DVL R-HSA-4641258 6.521511e-01 0.186 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 6.521511e-01 0.186 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 6.521511e-01 0.186 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 6.557379e-01 0.183 0 0
Heme signaling R-HSA-9707616 6.582699e-01 0.182 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 6.594365e-01 0.181 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 6.594365e-01 0.181 0 0
Fanconi Anemia Pathway R-HSA-6783310 6.594365e-01 0.181 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 6.628152e-01 0.179 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 6.628152e-01 0.179 0 0
Prolactin receptor signaling R-HSA-1170546 6.634440e-01 0.178 0 0
Removal of the Flap Intermediate R-HSA-69166 6.634440e-01 0.178 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 6.634440e-01 0.178 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 6.634440e-01 0.178 0 0
FGFR3c ligand binding and activation R-HSA-190372 6.634440e-01 0.178 0 0
Zinc transporters R-HSA-435354 6.634440e-01 0.178 0 0
Non-canonical inflammasome activation R-HSA-9686114 6.634440e-01 0.178 0 0
Cellular responses to stress R-HSA-2262752 6.637153e-01 0.178 0 0
Hedgehog 'on' state R-HSA-5632684 6.658755e-01 0.177 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 6.658755e-01 0.177 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 6.662681e-01 0.176 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 6.665341e-01 0.176 0 0
Chaperonin-mediated protein folding R-HSA-390466 6.670987e-01 0.176 0 0
Interleukin-12 family signaling R-HSA-447115 6.670987e-01 0.176 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 6.693159e-01 0.174 0 0
MET promotes cell motility R-HSA-8875878 6.711917e-01 0.173 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 6.711917e-01 0.173 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 6.711917e-01 0.173 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 6.784834e-01 0.168 0 0
Adaptive Immune System R-HSA-1280218 6.793797e-01 0.168 0 0
Autointegration results in viral DNA circles R-HSA-177539 6.794393e-01 0.168 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 6.794393e-01 0.168 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.794393e-01 0.168 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.794393e-01 0.168 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.794393e-01 0.168 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.794393e-01 0.168 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 6.794393e-01 0.168 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 6.794393e-01 0.168 0 0
Abacavir transmembrane transport R-HSA-2161517 6.794393e-01 0.168 0 0
NADPH regeneration R-HSA-389542 6.794393e-01 0.168 0 0
Leukotriene receptors R-HSA-391906 6.794393e-01 0.168 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 6.794393e-01 0.168 0 0
VLDL assembly R-HSA-8866423 6.794393e-01 0.168 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 6.799986e-01 0.167 0 0
Signaling by KIT in disease R-HSA-9669938 6.864533e-01 0.163 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 6.864533e-01 0.163 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 6.864533e-01 0.163 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 6.864533e-01 0.163 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 6.864533e-01 0.163 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 6.868029e-01 0.163 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 6.868029e-01 0.163 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 6.868029e-01 0.163 0 0
Ion transport by P-type ATPases R-HSA-936837 6.880995e-01 0.162 0 0
Stabilization of p53 R-HSA-69541 6.895313e-01 0.161 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 6.919795e-01 0.160 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.919795e-01 0.160 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 6.919795e-01 0.160 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 6.919795e-01 0.160 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.919795e-01 0.160 0 0
FGFR3 ligand binding and activation R-HSA-190239 6.919795e-01 0.160 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.919795e-01 0.160 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 6.919795e-01 0.160 0 0
Formation of the anterior neural plate R-HSA-9823739 6.919795e-01 0.160 0 0
Protein methylation R-HSA-8876725 6.919795e-01 0.160 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 6.927325e-01 0.159 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 6.933661e-01 0.159 0 0
Vesicle-mediated transport R-HSA-5653656 6.974846e-01 0.156 0 0
Signaling by ERBB4 R-HSA-1236394 7.071322e-01 0.150 0 0
Signaling by NOTCH4 R-HSA-9013694 7.071322e-01 0.150 0 0
Aggrephagy R-HSA-9646399 7.071613e-01 0.150 0 0
Cilium Assembly R-HSA-5617833 7.083670e-01 0.150 0 0
Growth hormone receptor signaling R-HSA-982772 7.088274e-01 0.149 0 0
G alpha (q) signalling events R-HSA-416476 7.097000e-01 0.149 0 0
IRS-mediated signalling R-HSA-112399 7.126116e-01 0.147 0 0
Nucleotide Excision Repair R-HSA-5696398 7.151362e-01 0.146 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 7.175157e-01 0.144 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 7.175157e-01 0.144 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.175157e-01 0.144 0 0
FGFR3b ligand binding and activation R-HSA-190371 7.175157e-01 0.144 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 7.175157e-01 0.144 0 0
SOS-mediated signalling R-HSA-112412 7.175157e-01 0.144 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 7.175157e-01 0.144 0 0
mRNA Editing: C to U Conversion R-HSA-72200 7.175157e-01 0.144 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.175157e-01 0.144 0 0
PTK6 Expression R-HSA-8849473 7.175157e-01 0.144 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.175157e-01 0.144 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 7.175157e-01 0.144 0 0
LDL remodeling R-HSA-8964041 7.175157e-01 0.144 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 7.175157e-01 0.144 0 0
Activation of TRKA receptors R-HSA-187015 7.175157e-01 0.144 0 0
Phosphorylation of the APC/C R-HSA-176412 7.184868e-01 0.144 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 7.184868e-01 0.144 0 0
Attachment and Entry R-HSA-9678110 7.184868e-01 0.144 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 7.184868e-01 0.144 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 7.184868e-01 0.144 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 7.201303e-01 0.143 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 7.201303e-01 0.143 0 0
Signaling by FGFR R-HSA-190236 7.213360e-01 0.142 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 7.240778e-01 0.140 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 7.241664e-01 0.140 0 0
Gap junction trafficking and regulation R-HSA-157858 7.249713e-01 0.140 0 0
Degradation of CDH1 R-HSA-9766229 7.249713e-01 0.140 0 0
Nuclear RNA decay R-HSA-9930044 7.251434e-01 0.140 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 7.255722e-01 0.139 0 0
Protein folding R-HSA-391251 7.395738e-01 0.131 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 7.402808e-01 0.131 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 7.402808e-01 0.131 0 0
Regulation of beta-cell development R-HSA-186712 7.408474e-01 0.130 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 7.429550e-01 0.129 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.429550e-01 0.129 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 7.430452e-01 0.129 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 7.430452e-01 0.129 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 7.430452e-01 0.129 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 7.430452e-01 0.129 0 0
Synthesis of PG R-HSA-1483148 7.430452e-01 0.129 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.498535e-01 0.125 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 7.498535e-01 0.125 0 0
G protein gated Potassium channels R-HSA-1296059 7.498535e-01 0.125 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 7.498535e-01 0.125 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 7.498535e-01 0.125 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.498535e-01 0.125 0 0
Interleukin-7 signaling R-HSA-1266695 7.498535e-01 0.125 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.510713e-01 0.124 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.510713e-01 0.124 0 0
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597 7.510713e-01 0.124 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 7.510713e-01 0.124 0 0
Interleukin-9 signaling R-HSA-8985947 7.510713e-01 0.124 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.510713e-01 0.124 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.510713e-01 0.124 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.510713e-01 0.124 0 0
Alpha-defensins R-HSA-1462054 7.510713e-01 0.124 0 0
Sodium/Proton exchangers R-HSA-425986 7.510713e-01 0.124 0 0
Interleukin-23 signaling R-HSA-9020933 7.510713e-01 0.124 0 0
Hedgehog ligand biogenesis R-HSA-5358346 7.542231e-01 0.123 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 7.598739e-01 0.119 0 0
PTEN Regulation R-HSA-6807070 7.611908e-01 0.119 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 7.657434e-01 0.116 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 7.657434e-01 0.116 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 7.657434e-01 0.116 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 7.657434e-01 0.116 0 0
Uptake and function of anthrax toxins R-HSA-5210891 7.657434e-01 0.116 0 0
Immune System R-HSA-168256 7.662789e-01 0.116 0 0
TCR signaling R-HSA-202403 7.665236e-01 0.115 0 0
Interleukin-17 signaling R-HSA-448424 7.672885e-01 0.115 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 7.679692e-01 0.115 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 7.682505e-01 0.114 0 0
Signaling by EGFR in Cancer R-HSA-1643713 7.685597e-01 0.114 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 7.685597e-01 0.114 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.685597e-01 0.114 0 0
rRNA processing R-HSA-72312 7.778723e-01 0.109 0 0
Signaling by PDGF R-HSA-186797 7.794401e-01 0.108 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.806426e-01 0.108 0 0
Calcineurin activates NFAT R-HSA-2025928 7.806426e-01 0.108 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.806426e-01 0.108 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.806426e-01 0.108 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.806426e-01 0.108 0 0
Degradation of GABA R-HSA-916853 7.806426e-01 0.108 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 7.806426e-01 0.108 0 0
Lipophagy R-HSA-9613354 7.806426e-01 0.108 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.806426e-01 0.108 0 0
Cellular response to mitochondrial stress R-HSA-9840373 7.806426e-01 0.108 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.806426e-01 0.108 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 7.806426e-01 0.108 0 0
Gastrulation R-HSA-9758941 7.810030e-01 0.107 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 7.811351e-01 0.107 0 0
HCMV Infection R-HSA-9609646 7.846423e-01 0.105 0 0
DAP12 interactions R-HSA-2172127 7.846603e-01 0.105 0 0
Gap junction trafficking R-HSA-190828 7.846603e-01 0.105 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 7.861077e-01 0.105 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 7.861077e-01 0.105 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 7.861077e-01 0.105 0 0
Insulin processing R-HSA-264876 7.861077e-01 0.105 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 7.866769e-01 0.104 0 0
Activated point mutants of FGFR2 R-HSA-2033519 7.866769e-01 0.104 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 7.866769e-01 0.104 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.866769e-01 0.104 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 7.910980e-01 0.102 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 7.913110e-01 0.102 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 7.913276e-01 0.102 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 7.941069e-01 0.100 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 7.980755e-01 0.098 0 0
Ca2+ pathway R-HSA-4086398 8.009976e-01 0.096 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.025378e-01 0.096 0 0
HIV elongation arrest and recovery R-HSA-167287 8.025378e-01 0.096 0 0
Pausing and recovery of HIV elongation R-HSA-167290 8.025378e-01 0.096 0 0
Telomere Extension By Telomerase R-HSA-171319 8.025378e-01 0.096 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 8.025378e-01 0.096 0 0
E2F mediated regulation of DNA replication R-HSA-113510 8.059446e-01 0.094 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 8.059446e-01 0.094 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 8.059446e-01 0.094 0 0
Other interleukin signaling R-HSA-449836 8.059446e-01 0.094 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 8.067025e-01 0.093 0 0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 8.067025e-01 0.093 0 0
Regulation of the apoptosome activity R-HSA-9627069 8.067025e-01 0.093 0 0
Formation of apoptosome R-HSA-111458 8.067025e-01 0.093 0 0
PI3K/AKT activation R-HSA-198203 8.067025e-01 0.093 0 0
Binding and entry of HIV virion R-HSA-173107 8.067025e-01 0.093 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.067025e-01 0.093 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 8.067025e-01 0.093 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 8.067025e-01 0.093 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.067025e-01 0.093 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 8.067025e-01 0.093 0 0
Maturation of spike protein R-HSA-9683686 8.067025e-01 0.093 0 0
Sperm Motility And Taxes R-HSA-1300642 8.067025e-01 0.093 0 0
MAPK3 (ERK1) activation R-HSA-110056 8.067025e-01 0.093 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.067025e-01 0.093 0 0
Josephin domain DUBs R-HSA-5689877 8.067025e-01 0.093 0 0
Serotonin receptors R-HSA-390666 8.067025e-01 0.093 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 8.067025e-01 0.093 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.108237e-01 0.091 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.108237e-01 0.091 0 0
Neutrophil degranulation R-HSA-6798695 8.155936e-01 0.089 0 0
SARS-CoV-2 Infection R-HSA-9694516 8.172212e-01 0.088 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.172314e-01 0.088 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 8.178937e-01 0.087 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 8.236466e-01 0.084 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 8.236466e-01 0.084 0 0
Signaling by NODAL R-HSA-1181150 8.236466e-01 0.084 0 0
Signal transduction by L1 R-HSA-445144 8.236466e-01 0.084 0 0
PPARA activates gene expression R-HSA-1989781 8.251648e-01 0.083 0 0
Signaling by Insulin receptor R-HSA-74752 8.276522e-01 0.082 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 8.296679e-01 0.081 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 8.296679e-01 0.081 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.296679e-01 0.081 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.296679e-01 0.081 0 0
Chylomicron assembly R-HSA-8963888 8.296679e-01 0.081 0 0
Transport of RCbl within the body R-HSA-9758890 8.296679e-01 0.081 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.296679e-01 0.081 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 8.296679e-01 0.081 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.296679e-01 0.081 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 8.296679e-01 0.081 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 8.317262e-01 0.080 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.317262e-01 0.080 0 0
Activation of the pre-replicative complex R-HSA-68962 8.322215e-01 0.080 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 8.322215e-01 0.080 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.322215e-01 0.080 0 0
Intraflagellar transport R-HSA-5620924 8.343852e-01 0.079 0 0
Metal ion SLC transporters R-HSA-425410 8.343852e-01 0.079 0 0
Cellular response to chemical stress R-HSA-9711123 8.380327e-01 0.077 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.383364e-01 0.077 0 0
G-protein activation R-HSA-202040 8.398830e-01 0.076 0 0
FGFR2 ligand binding and activation R-HSA-190241 8.398830e-01 0.076 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 8.398830e-01 0.076 0 0
G1/S Transition R-HSA-69206 8.421892e-01 0.075 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 8.437171e-01 0.074 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 8.437171e-01 0.074 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.437171e-01 0.074 0 0
HIV Transcription Elongation R-HSA-167169 8.437171e-01 0.074 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.437171e-01 0.074 0 0
Glycogen metabolism R-HSA-8982491 8.437171e-01 0.074 1 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.446383e-01 0.073 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 8.452352e-01 0.073 0 0
SLC transporter disorders R-HSA-5619102 8.456251e-01 0.073 0 0
PCP/CE pathway R-HSA-4086400 8.487895e-01 0.071 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 8.499059e-01 0.071 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 8.499059e-01 0.071 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.499059e-01 0.071 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 8.499059e-01 0.071 0 0
ERKs are inactivated R-HSA-202670 8.499059e-01 0.071 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.499059e-01 0.071 0 0
Sodium/Calcium exchangers R-HSA-425561 8.499059e-01 0.071 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.499059e-01 0.071 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 8.547520e-01 0.068 0 0
Attachment and Entry R-HSA-9694614 8.547520e-01 0.068 0 0
Signaling by PDGFR in disease R-HSA-9671555 8.547520e-01 0.068 0 0
Signaling by MET R-HSA-6806834 8.651430e-01 0.063 0 0
HSF1-dependent transactivation R-HSA-3371571 8.651732e-01 0.063 0 0
The phototransduction cascade R-HSA-2514856 8.651732e-01 0.063 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 8.655442e-01 0.063 0 0
Intra-Golgi traffic R-HSA-6811438 8.655442e-01 0.063 0 0
Translation of Structural Proteins R-HSA-9683701 8.655442e-01 0.063 0 0
COPI-mediated anterograde transport R-HSA-6807878 8.668112e-01 0.062 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.677404e-01 0.062 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.677404e-01 0.062 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.677404e-01 0.062 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.677404e-01 0.062 0 0
MET activates RAS signaling R-HSA-8851805 8.677404e-01 0.062 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 8.677404e-01 0.062 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.677404e-01 0.062 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.677404e-01 0.062 0 0
Regulation of IFNG signaling R-HSA-877312 8.677404e-01 0.062 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.677404e-01 0.062 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.677404e-01 0.062 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.677404e-01 0.062 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.677404e-01 0.062 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.679080e-01 0.062 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.683494e-01 0.061 0 0
FGFR2 alternative splicing R-HSA-6803529 8.683494e-01 0.061 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.683494e-01 0.061 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 8.683494e-01 0.061 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.683494e-01 0.061 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 8.743032e-01 0.058 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.743032e-01 0.058 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.754411e-01 0.058 0 0
Organelle biogenesis and maintenance R-HSA-1852241 8.772071e-01 0.057 0 0
Selenoamino acid metabolism R-HSA-2408522 8.786166e-01 0.056 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.802105e-01 0.055 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 8.807673e-01 0.055 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 8.807673e-01 0.055 0 0
Carnitine shuttle R-HSA-200425 8.807673e-01 0.055 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 8.829028e-01 0.054 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 8.829028e-01 0.054 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.829028e-01 0.054 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 8.834567e-01 0.054 0 0
Acetylcholine binding and downstream events R-HSA-181431 8.834567e-01 0.054 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 8.834567e-01 0.054 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.834567e-01 0.054 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 8.834567e-01 0.054 0 0
Mtb iron assimilation by chelation R-HSA-1222449 8.834567e-01 0.054 0 0
rRNA modification in the mitochondrion R-HSA-6793080 8.834567e-01 0.054 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.834567e-01 0.054 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.834567e-01 0.054 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.869479e-01 0.052 0 0
Calnexin/calreticulin cycle R-HSA-901042 8.901187e-01 0.051 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.901187e-01 0.051 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 8.917230e-01 0.050 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 8.920939e-01 0.050 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.920939e-01 0.050 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.920939e-01 0.050 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.920939e-01 0.050 0 0
TNFs bind their physiological receptors R-HSA-5669034 8.920939e-01 0.050 0 0
Interleukin-6 family signaling R-HSA-6783589 8.920939e-01 0.050 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.973062e-01 0.047 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.973062e-01 0.047 0 0
NRIF signals cell death from the nucleus R-HSA-205043 8.973062e-01 0.047 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 8.973062e-01 0.047 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 8.973062e-01 0.047 0 0
Vitamin B2 (riboflavin) metabolism R-HSA-196843 8.973062e-01 0.047 0 0
N-glycan trimming and elongation in the cis-Golgi R-HSA-964739 8.973062e-01 0.047 0 0
Physiological factors R-HSA-5578768 8.973062e-01 0.047 0 0
Glycerophospholipid catabolism R-HSA-6814848 8.973062e-01 0.047 0 0
HDL assembly R-HSA-8963896 8.973062e-01 0.047 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.973062e-01 0.047 0 0
P2Y receptors R-HSA-417957 8.973062e-01 0.047 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.973062e-01 0.047 0 0
Interferon gamma signaling R-HSA-877300 8.982861e-01 0.047 0 0
Protein ubiquitination R-HSA-8852135 8.984008e-01 0.047 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 8.985982e-01 0.046 0 0
Potential therapeutics for SARS R-HSA-9679191 8.989505e-01 0.046 0 0
Mitochondrial biogenesis R-HSA-1592230 8.991638e-01 0.046 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 9.077581e-01 0.042 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.077581e-01 0.042 0 0
RNA Polymerase III Transcription R-HSA-74158 9.077581e-01 0.042 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 9.095106e-01 0.041 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.095106e-01 0.041 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.095106e-01 0.041 0 0
Erythropoietin activates RAS R-HSA-9027284 9.095106e-01 0.041 0 0
Telomere C-strand synthesis initiation R-HSA-174430 9.095106e-01 0.041 0 0
Protein lipoylation R-HSA-9857492 9.095106e-01 0.041 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 9.095106e-01 0.041 0 0
Signaling by Activin R-HSA-1502540 9.095106e-01 0.041 0 0
Protein repair R-HSA-5676934 9.095106e-01 0.041 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.095106e-01 0.041 0 0
Other semaphorin interactions R-HSA-416700 9.095106e-01 0.041 0 0
Kidney development R-HSA-9830369 9.109154e-01 0.041 0 0
MET activates PTK2 signaling R-HSA-8874081 9.118048e-01 0.040 0 0
SARS-CoV Infections R-HSA-9679506 9.138205e-01 0.039 0 0
Transcription of the HIV genome R-HSA-167172 9.168877e-01 0.038 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.187095e-01 0.037 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.202653e-01 0.036 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.202653e-01 0.036 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.202653e-01 0.036 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 9.202653e-01 0.036 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.202653e-01 0.036 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 9.202653e-01 0.036 0 0
Activation of the phototransduction cascade R-HSA-2485179 9.202653e-01 0.036 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 9.202653e-01 0.036 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 9.202653e-01 0.036 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 9.202653e-01 0.036 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 9.202653e-01 0.036 0 0
Differentiation of T cells R-HSA-9945266 9.202653e-01 0.036 0 0
Fructose catabolism R-HSA-70350 9.202653e-01 0.036 0 0
Atorvastatin ADME R-HSA-9754706 9.202653e-01 0.036 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.203431e-01 0.036 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.203431e-01 0.036 0 0
Signaling by BMP R-HSA-201451 9.203431e-01 0.036 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.203431e-01 0.036 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.245840e-01 0.034 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.251793e-01 0.034 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.254672e-01 0.034 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.267043e-01 0.033 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 9.277916e-01 0.033 0 0
Insulin receptor recycling R-HSA-77387 9.280983e-01 0.032 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.280983e-01 0.032 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.291898e-01 0.032 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.297423e-01 0.032 0 0
Glycine degradation R-HSA-6783984 9.297423e-01 0.032 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.297423e-01 0.032 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 9.297423e-01 0.032 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 9.297423e-01 0.032 0 0
Scavenging by Class B Receptors R-HSA-3000471 9.297423e-01 0.032 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 9.297423e-01 0.032 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.297423e-01 0.032 0 0
Galactose catabolism R-HSA-70370 9.297423e-01 0.032 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.297423e-01 0.032 0 0
Response to metal ions R-HSA-5660526 9.297423e-01 0.032 0 0
Formation of the cornified envelope R-HSA-6809371 9.306256e-01 0.031 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 9.327553e-01 0.030 0 0
Regulation of mitotic cell cycle R-HSA-453276 9.327553e-01 0.030 0 0
Late endosomal microautophagy R-HSA-9615710 9.351360e-01 0.029 0 0
Glucagon-type ligand receptors R-HSA-420092 9.351360e-01 0.029 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.355474e-01 0.029 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.355474e-01 0.029 0 0
Attenuation phase R-HSA-3371568 9.355474e-01 0.029 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.357611e-01 0.029 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.380934e-01 0.028 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 9.380934e-01 0.028 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.380934e-01 0.028 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.380934e-01 0.028 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 9.380934e-01 0.028 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.380934e-01 0.028 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.400066e-01 0.027 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.411686e-01 0.026 0 0
Maturation of spike protein R-HSA-9694548 9.411686e-01 0.026 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.415170e-01 0.026 0 0
Neurotransmitter clearance R-HSA-112311 9.415170e-01 0.026 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.415170e-01 0.026 0 0
Interleukin-1 signaling R-HSA-9020702 9.430861e-01 0.025 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.442982e-01 0.025 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.450089e-01 0.025 0 0
Chaperone Mediated Autophagy R-HSA-9613829 9.454523e-01 0.024 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.454523e-01 0.024 0 0
Transport of connexons to the plasma membrane R-HSA-190872 9.454523e-01 0.024 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.454523e-01 0.024 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.454523e-01 0.024 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.454523e-01 0.024 0 0
Signaling by FGFR in disease R-HSA-1226099 9.458794e-01 0.024 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.463323e-01 0.024 0 0
HIV Transcription Initiation R-HSA-167161 9.463323e-01 0.024 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.463323e-01 0.024 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.463323e-01 0.024 0 0
Cargo concentration in the ER R-HSA-5694530 9.472981e-01 0.024 0 0
Budding and maturation of HIV virion R-HSA-162588 9.472981e-01 0.024 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.472981e-01 0.024 0 0
Smooth Muscle Contraction R-HSA-445355 9.487897e-01 0.023 0 0
Collagen formation R-HSA-1474290 9.503850e-01 0.022 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.510718e-01 0.022 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 9.519368e-01 0.021 0 0
Pyrimidine biosynthesis R-HSA-500753 9.519368e-01 0.021 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.519368e-01 0.021 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.519368e-01 0.021 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.519368e-01 0.021 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.519368e-01 0.021 0 0
Crosslinking of collagen fibrils R-HSA-2243919 9.519368e-01 0.021 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.519368e-01 0.021 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.529134e-01 0.021 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.554181e-01 0.020 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.554181e-01 0.020 0 0
Translation of Structural Proteins R-HSA-9694635 9.566582e-01 0.019 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.572660e-01 0.019 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.576507e-01 0.019 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 9.576507e-01 0.019 0 0
Negative regulation of MET activity R-HSA-6807004 9.576507e-01 0.019 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.576507e-01 0.019 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.576507e-01 0.019 0 0
Keratan sulfate degradation R-HSA-2022857 9.576507e-01 0.019 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.576507e-01 0.019 0 0
Pregnenolone biosynthesis R-HSA-196108 9.576507e-01 0.019 0 0
Glycogen synthesis R-HSA-3322077 9.576507e-01 0.019 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.594009e-01 0.018 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 9.603428e-01 0.018 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.615460e-01 0.017 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 9.626271e-01 0.017 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 9.626857e-01 0.017 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.626857e-01 0.017 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.626857e-01 0.017 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.626857e-01 0.017 0 0
Basigin interactions R-HSA-210991 9.626857e-01 0.017 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.627213e-01 0.016 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.630477e-01 0.016 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.630477e-01 0.016 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.630477e-01 0.016 0 0
ER-Phagosome pathway R-HSA-1236974 9.634924e-01 0.016 0 0
Synthesis of DNA R-HSA-69239 9.637917e-01 0.016 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.645137e-01 0.016 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.654127e-01 0.015 0 0
eNOS activation R-HSA-203615 9.654127e-01 0.015 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.654127e-01 0.015 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.654127e-01 0.015 0 0
Signaling by NOTCH2 R-HSA-1980145 9.654127e-01 0.015 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.654127e-01 0.015 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.661186e-01 0.015 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.671223e-01 0.015 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.671223e-01 0.015 0 0
Assembly Of The HIV Virion R-HSA-175474 9.671223e-01 0.015 0 0
Glutathione synthesis and recycling R-HSA-174403 9.671223e-01 0.015 0 0
COPII-mediated vesicle transport R-HSA-204005 9.682187e-01 0.014 0 0
Regulation of Apoptosis R-HSA-169911 9.689038e-01 0.014 0 0
Platelet degranulation R-HSA-114608 9.693380e-01 0.014 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.694353e-01 0.013 0 0
Synthesis of PC R-HSA-1483191 9.694353e-01 0.013 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.699865e-01 0.013 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.699865e-01 0.013 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.710316e-01 0.013 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.710316e-01 0.013 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.710316e-01 0.013 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.710316e-01 0.013 0 0
LDL clearance R-HSA-8964038 9.710316e-01 0.013 0 0
Fructose metabolism R-HSA-5652084 9.710316e-01 0.013 0 0
Ethanol oxidation R-HSA-71384 9.710316e-01 0.013 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.710316e-01 0.013 0 0
Cellular hexose transport R-HSA-189200 9.710316e-01 0.013 0 0
tRNA Aminoacylation R-HSA-379724 9.720102e-01 0.012 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.720102e-01 0.012 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.720540e-01 0.012 0 0
HSF1 activation R-HSA-3371511 9.720540e-01 0.012 0 0
Triglyceride catabolism R-HSA-163560 9.720540e-01 0.012 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.725860e-01 0.012 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.727486e-01 0.012 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.743774e-01 0.011 0 0
Collagen degradation R-HSA-1442490 9.743774e-01 0.011 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.744763e-01 0.011 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.744763e-01 0.011 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.744763e-01 0.011 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.744763e-01 0.011 0 0
Formation of the ureteric bud R-HSA-9830674 9.744763e-01 0.011 0 0
Biosynthesis of maresins R-HSA-9018682 9.744763e-01 0.011 0 0
Interleukin-20 family signaling R-HSA-8854691 9.744763e-01 0.011 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.748949e-01 0.011 0 0
NCAM1 interactions R-HSA-419037 9.748949e-01 0.011 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.771531e-01 0.010 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.773552e-01 0.010 0 0
Leishmania phagocytosis R-HSA-9664417 9.773552e-01 0.010 0 0
Parasite infection R-HSA-9664407 9.773552e-01 0.010 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.774556e-01 0.010 0 0
Elastic fibre formation R-HSA-1566948 9.774556e-01 0.010 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 9.775116e-01 0.010 0 0
Complex III assembly R-HSA-9865881 9.775116e-01 0.010 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.775116e-01 0.010 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.783378e-01 0.010 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.785590e-01 0.009 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.787333e-01 0.009 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.792091e-01 0.009 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.796425e-01 0.009 0 0
tRNA processing R-HSA-72306 9.796508e-01 0.009 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.797625e-01 0.009 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.797625e-01 0.009 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.797625e-01 0.009 0 0
RAS processing R-HSA-9648002 9.797625e-01 0.009 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.797625e-01 0.009 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.801860e-01 0.009 0 0
Hyaluronan degradation R-HSA-2160916 9.801860e-01 0.009 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.801860e-01 0.009 0 0
Fertilization R-HSA-1187000 9.801860e-01 0.009 0 0
Retinoid cycle disease events R-HSA-2453864 9.801860e-01 0.009 0 0
Diseases associated with visual transduction R-HSA-2474795 9.801860e-01 0.009 0 0
Diseases of the neuronal system R-HSA-9675143 9.801860e-01 0.009 0 0
Laminin interactions R-HSA-3000157 9.801860e-01 0.009 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.811397e-01 0.008 0 0
Cellular response to hypoxia R-HSA-1234174 9.820909e-01 0.008 0 0
Urea cycle R-HSA-70635 9.825426e-01 0.008 0 0
Sphingolipid catabolism R-HSA-9845614 9.825426e-01 0.008 0 0
Abacavir ADME R-HSA-2161522 9.825426e-01 0.008 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.828983e-01 0.007 0 0
Nucleotide biosynthesis R-HSA-8956320 9.828983e-01 0.007 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.837093e-01 0.007 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.837093e-01 0.007 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.837093e-01 0.007 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.841582e-01 0.007 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 9.846190e-01 0.007 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.846190e-01 0.007 0 0
Triglyceride biosynthesis R-HSA-75109 9.846190e-01 0.007 0 0
Synthesis of PE R-HSA-1483213 9.846190e-01 0.007 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.846190e-01 0.007 0 0
Downstream TCR signaling R-HSA-202424 9.854980e-01 0.006 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.859560e-01 0.006 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.863731e-01 0.006 0 0
Formation of the Early Elongation Complex R-HSA-113418 9.864485e-01 0.006 0 0
Prednisone ADME R-HSA-9757110 9.864485e-01 0.006 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 9.864485e-01 0.006 0 0
Pyrimidine salvage R-HSA-73614 9.864485e-01 0.006 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 9.869035e-01 0.006 0 0
mRNA Capping R-HSA-72086 9.880605e-01 0.005 0 0
Thyroxine biosynthesis R-HSA-209968 9.880605e-01 0.005 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.880605e-01 0.005 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.880605e-01 0.005 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.880605e-01 0.005 0 0
Dectin-2 family R-HSA-5621480 9.884851e-01 0.005 0 0
Synthesis of PA R-HSA-1483166 9.884851e-01 0.005 0 0
Mucopolysaccharidoses R-HSA-2206281 9.894808e-01 0.005 0 0
Circadian clock R-HSA-9909396 9.898035e-01 0.004 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.904998e-01 0.004 0 0
Triglyceride metabolism R-HSA-8979227 9.905727e-01 0.004 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.905813e-01 0.004 0 0
Somitogenesis R-HSA-9824272 9.905813e-01 0.004 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.907323e-01 0.004 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.907323e-01 0.004 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.907323e-01 0.004 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.907323e-01 0.004 0 0
Switching of origins to a post-replicative state R-HSA-69052 9.914277e-01 0.004 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.914745e-01 0.004 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 9.915662e-01 0.004 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.915662e-01 0.004 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.918349e-01 0.004 0 0
Interferon alpha/beta signaling R-HSA-909733 9.918527e-01 0.004 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.923469e-01 0.003 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.924502e-01 0.003 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.925533e-01 0.003 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.925533e-01 0.003 0 0
Viral Infection Pathways R-HSA-9824446 9.926317e-01 0.003 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.928064e-01 0.003 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.928064e-01 0.003 0 0
Recycling of bile acids and salts R-HSA-159418 9.928064e-01 0.003 0 0
Peptide hormone metabolism R-HSA-2980736 9.930227e-01 0.003 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.930348e-01 0.003 0 0
Gluconeogenesis R-HSA-70263 9.932432e-01 0.003 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.936624e-01 0.003 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.936624e-01 0.003 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.936624e-01 0.003 0 0
Heme degradation R-HSA-189483 9.936624e-01 0.003 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 9.936624e-01 0.003 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.936921e-01 0.003 0 0
Hyaluronan metabolism R-HSA-2142845 9.944165e-01 0.002 0 0
Gap junction assembly R-HSA-190861 9.944165e-01 0.002 0 0
Extracellular matrix organization R-HSA-1474244 9.945804e-01 0.002 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.945922e-01 0.002 0 0
G alpha (i) signalling events R-HSA-418594 9.946109e-01 0.002 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.946232e-01 0.002 0 0
ABC transporter disorders R-HSA-5619084 9.946568e-01 0.002 0 0
Integrin cell surface interactions R-HSA-216083 9.946568e-01 0.002 0 0
ABC-family proteins mediated transport R-HSA-382556 9.946829e-01 0.002 0 0
Neurotransmitter release cycle R-HSA-112310 9.947941e-01 0.002 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.950810e-01 0.002 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.950810e-01 0.002 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.951638e-01 0.002 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.953688e-01 0.002 0 0
IRE1alpha activates chaperones R-HSA-381070 9.956562e-01 0.002 0 0
Glycosphingolipid transport R-HSA-9845576 9.956664e-01 0.002 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.956664e-01 0.002 0 0
Orc1 removal from chromatin R-HSA-68949 9.956760e-01 0.002 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.956760e-01 0.002 0 0
Nicotinate metabolism R-HSA-196807 9.958212e-01 0.002 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.961348e-01 0.002 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.961821e-01 0.002 0 0
Degradation of AXIN R-HSA-4641257 9.961821e-01 0.002 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.961821e-01 0.002 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.961821e-01 0.002 0 0
Collagen chain trimerization R-HSA-8948216 9.961821e-01 0.002 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.965457e-01 0.002 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.966366e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.968047e-01 0.001 0 0
Pentose phosphate pathway R-HSA-71336 9.970369e-01 0.001 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.970369e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.972378e-01 0.001 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.973896e-01 0.001 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.973896e-01 0.001 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.973896e-01 0.001 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.974821e-01 0.001 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.975111e-01 0.001 0 0
XBP1(S) activates chaperone genes R-HSA-381038 9.977645e-01 0.001 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.979741e-01 0.001 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.979741e-01 0.001 0 0
Heme biosynthesis R-HSA-189451 9.979741e-01 0.001 0 0
Peroxisomal protein import R-HSA-9033241 9.980368e-01 0.001 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.981820e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.982263e-01 0.001 0 0
Defensins R-HSA-1461973 9.984278e-01 0.001 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.984278e-01 0.001 0 0
Neddylation R-HSA-8951664 9.985637e-01 0.001 0 0
Mitochondrial protein import R-HSA-1268020 9.986044e-01 0.001 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.986150e-01 0.001 0 0
Proteasome assembly R-HSA-9907900 9.986150e-01 0.001 0 0
Methylation R-HSA-156581 9.986150e-01 0.001 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.986150e-01 0.001 0 0
Surfactant metabolism R-HSA-5683826 9.986150e-01 0.001 0 0
Cholesterol biosynthesis R-HSA-191273 9.986750e-01 0.001 0 0
The canonical retinoid cycle in rods (twilight vision) R-HSA-2453902 9.987800e-01 0.001 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.987800e-01 0.001 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.988242e-01 0.001 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.988828e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.989203e-01 0.000 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.989252e-01 0.000 0 0
RSV-host interactions R-HSA-9833110 9.989253e-01 0.000 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.989279e-01 0.000 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.990532e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.990532e-01 0.000 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.991660e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.991853e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.992125e-01 0.000 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.992653e-01 0.000 0 0
Keratan sulfate/keratin metabolism R-HSA-1638074 9.992653e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.992653e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.993244e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.993528e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.994299e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.994424e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.994514e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.995032e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.995032e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.995032e-01 0.000 0 0
Translation R-HSA-72766 9.996325e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.996977e-01 0.000 0 0
Digestion R-HSA-8935690 9.996977e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.997793e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.997934e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.997934e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.998091e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.998180e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.998180e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.998397e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.998397e-01 0.000 0 0
Keratinization R-HSA-6805567 9.998513e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.998626e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.998697e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.998756e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.998756e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.998897e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.998905e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.998905e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999035e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999085e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.999252e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999314e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.999341e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999365e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999489e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999518e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999529e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999550e-01 0.000 0 0
Disease R-HSA-1643685 9.999585e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999603e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999651e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999699e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999709e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.999729e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999763e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.999792e-01 0.000 0 0
Protein localization R-HSA-9609507 9.999807e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999815e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999837e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999874e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999874e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999899e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999914e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999928e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999936e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999941e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999952e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999954e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999965e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999969e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999977e-01 0.000 1 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999991e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999993e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999994e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999999e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999999e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999999e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999999e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999999e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999999e-01 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 1 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle, Mitotic R-HSA-69278 1.110223e-16 15.955 0 0
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 0 0
Cellular responses to stimuli R-HSA-8953897 1.110223e-16 15.955 0 0
Cellular responses to stress R-HSA-2262752 1.776357e-15 14.750 0 0
M Phase R-HSA-68886 9.214851e-15 14.036 0 0
Cell Cycle Checkpoints R-HSA-69620 1.832978e-12 11.737 0 0
Axon guidance R-HSA-422475 2.573719e-12 11.589 0 0
Nervous system development R-HSA-9675108 1.609490e-11 10.793 0 0
Mitotic Anaphase R-HSA-68882 6.272005e-11 10.203 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 7.419443e-11 10.130 0 0
Cell-Cell communication R-HSA-1500931 1.277858e-10 9.894 0 0
Cellular Senescence R-HSA-2559583 2.630826e-10 9.580 0 0
Separation of Sister Chromatids R-HSA-2467813 6.833540e-10 9.165 0 0
HSF1-dependent transactivation R-HSA-3371571 8.670406e-10 9.062 0 0
Cellular response to heat stress R-HSA-3371556 9.028920e-10 9.044 0 0
Mitotic Prometaphase R-HSA-68877 9.314726e-10 9.031 0 0
Cell junction organization R-HSA-446728 1.363524e-09 8.865 0 0
Metabolism of RNA R-HSA-8953854 2.336235e-09 8.631 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.745917e-09 8.561 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.911713e-09 8.408 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 8.009041e-09 8.096 0 0
Post NMDA receptor activation events R-HSA-438064 1.359960e-08 7.866 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.673055e-08 7.776 0 0
Attenuation phase R-HSA-3371568 2.052029e-08 7.688 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.870766e-08 7.542 0 0
G2/M Checkpoints R-HSA-69481 3.169178e-08 7.499 0 0
mRNA Splicing - Major Pathway R-HSA-72163 4.263710e-08 7.370 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 6.502116e-08 7.187 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 6.502116e-08 7.187 0 0
Recycling pathway of L1 R-HSA-437239 7.322821e-08 7.135 0 0
Eukaryotic Translation Initiation R-HSA-72613 7.333551e-08 7.135 0 0
Cap-dependent Translation Initiation R-HSA-72737 7.333551e-08 7.135 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 6.934196e-08 7.159 0 0
mRNA Splicing R-HSA-72172 8.625494e-08 7.064 0 0
Membrane Trafficking R-HSA-199991 1.268380e-07 6.897 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.471748e-07 6.832 0 0
G2/M Transition R-HSA-69275 1.823431e-07 6.739 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.822024e-07 6.739 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.875096e-07 6.727 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.995035e-07 6.700 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 2.204493e-07 6.657 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.346853e-07 6.630 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.414360e-07 6.617 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.476124e-07 6.606 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 3.022455e-07 6.520 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.981998e-07 6.525 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 3.107344e-07 6.508 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 3.914179e-07 6.407 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.328288e-07 6.364 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.624170e-07 6.335 0 0
Translation initiation complex formation R-HSA-72649 5.688622e-07 6.245 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 6.898184e-07 6.161 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 7.293067e-07 6.137 0 0
Signaling by ROBO receptors R-HSA-376176 7.808115e-07 6.107 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 9.653972e-07 6.015 0 0
Cell-cell junction organization R-HSA-421270 1.283221e-06 5.892 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.287559e-06 5.890 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.338216e-06 5.873 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.460105e-06 5.836 0 0
L1CAM interactions R-HSA-373760 1.473905e-06 5.832 0 0
Aggrephagy R-HSA-9646399 1.567265e-06 5.805 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.580220e-06 5.801 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.664416e-06 5.779 0 0
HSF1 activation R-HSA-3371511 1.812113e-06 5.742 0 0
Homology Directed Repair R-HSA-5693538 2.052144e-06 5.688 0 0
Transport of connexons to the plasma membrane R-HSA-190872 2.080508e-06 5.682 0 0
PKR-mediated signaling R-HSA-9833482 2.239637e-06 5.650 0 0
Adherens junctions interactions R-HSA-418990 2.522440e-06 5.598 0 0
Kinesins R-HSA-983189 2.603393e-06 5.584 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.746614e-06 5.561 0 0
Mitotic Prophase R-HSA-68875 2.834511e-06 5.548 0 0
Apoptotic execution phase R-HSA-75153 3.086939e-06 5.510 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 3.356959e-06 5.474 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.558428e-06 5.449 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.111225e-06 5.386 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 4.147547e-06 5.382 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.534211e-06 5.343 0 0
Selective autophagy R-HSA-9663891 4.534211e-06 5.343 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.712391e-06 5.327 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 4.965445e-06 5.304 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 4.989768e-06 5.302 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 5.081977e-06 5.294 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.324644e-06 5.274 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 5.559269e-06 5.255 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 6.033299e-06 5.219 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 6.705307e-06 5.174 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 6.926330e-06 5.159 0 0
Chromatin modifying enzymes R-HSA-3247509 7.226413e-06 5.141 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 8.402932e-06 5.076 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.349946e-06 5.029 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.349946e-06 5.029 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.383816e-06 5.028 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.090166e-05 4.963 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.037129e-05 4.984 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.130957e-05 4.947 0 0
Peptide chain elongation R-HSA-156902 1.251430e-05 4.903 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.301230e-05 4.886 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.327763e-05 4.877 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.465053e-05 4.834 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.548075e-05 4.810 0 0
HCMV Early Events R-HSA-9609690 1.550048e-05 4.810 0 0
HATs acetylate histones R-HSA-3214847 1.635652e-05 4.786 0 0
Chromatin organization R-HSA-4839726 1.692339e-05 4.772 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.722719e-05 4.764 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 2.113754e-05 4.675 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.191579e-05 4.659 0 0
Gap junction trafficking and regulation R-HSA-157858 2.258915e-05 4.646 0 0
Ribosome-associated quality control R-HSA-9948299 2.464452e-05 4.608 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.499986e-05 4.602 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.659621e-05 4.575 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 2.669409e-05 4.574 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.722538e-05 4.565 0 0
HDACs deacetylate histones R-HSA-3214815 2.742643e-05 4.562 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 2.889598e-05 4.539 0 0
Nucleosome assembly R-HSA-774815 2.889598e-05 4.539 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 3.312814e-05 4.480 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.279705e-05 4.484 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 3.314890e-05 4.480 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 3.314890e-05 4.480 0 0
DNA Double Strand Break Response R-HSA-5693606 3.599024e-05 4.444 0 0
Influenza Infection R-HSA-168255 4.286036e-05 4.368 0 0
Mitotic Spindle Checkpoint R-HSA-69618 4.811549e-05 4.318 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.784885e-05 4.320 0 0
Programmed Cell Death R-HSA-5357801 4.525852e-05 4.344 0 0
Apoptosis R-HSA-109581 5.100849e-05 4.292 0 0
Ephrin signaling R-HSA-3928664 5.541386e-05 4.256 0 0
Meiotic synapsis R-HSA-1221632 5.505579e-05 4.259 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 5.277644e-05 4.278 0 0
Amplification of signal from the kinetochores R-HSA-141424 5.277644e-05 4.278 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 5.443860e-05 4.264 0 0
Autophagy R-HSA-9612973 5.381340e-05 4.269 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 5.766277e-05 4.239 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 6.743631e-05 4.171 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 7.162233e-05 4.145 0 0
Gap junction trafficking R-HSA-190828 7.494784e-05 4.125 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 7.678060e-05 4.115 0 0
Macroautophagy R-HSA-1632852 7.925211e-05 4.101 0 0
Diseases of programmed cell death R-HSA-9645723 8.565975e-05 4.067 0 0
RNA Polymerase I Transcription R-HSA-73864 9.492575e-05 4.023 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.074334e-04 3.969 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.108163e-04 3.955 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.153192e-04 3.938 0 0
Viral Infection Pathways R-HSA-9824446 1.240893e-04 3.906 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 1.373070e-04 3.862 0 0
Gene Silencing by RNA R-HSA-211000 1.509246e-04 3.821 0 0
DNA methylation R-HSA-5334118 1.513527e-04 3.820 0 0
Protein folding R-HSA-391251 1.823066e-04 3.739 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.826619e-04 3.738 0 0
EPH-Ephrin signaling R-HSA-2682334 1.823066e-04 3.739 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.772678e-04 3.751 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.758829e-04 3.755 0 0
Defective pyroptosis R-HSA-9710421 1.898479e-04 3.722 0 0
S Phase R-HSA-69242 1.986503e-04 3.702 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 2.018605e-04 3.695 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 2.021942e-04 3.694 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 2.165715e-04 3.664 0 0
Signal Transduction R-HSA-162582 2.243101e-04 3.649 0 0
HCMV Infection R-HSA-9609646 2.277689e-04 3.643 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.786601e-04 3.555 0 0
Vesicle-mediated transport R-HSA-5653656 2.817906e-04 3.550 0 0
Meiosis R-HSA-1500620 2.853300e-04 3.545 0 0
Interferon Signaling R-HSA-913531 2.905802e-04 3.537 0 0
Packaging Of Telomere Ends R-HSA-171306 3.225253e-04 3.491 0 0
Eukaryotic Translation Termination R-HSA-72764 3.195439e-04 3.495 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.005347e-04 3.522 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.294710e-04 3.482 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 3.311401e-04 3.480 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 3.315775e-04 3.479 0 0
DNA Replication R-HSA-69306 3.385413e-04 3.470 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.414155e-04 3.467 0 0
Signaling by ALK in cancer R-HSA-9700206 3.414155e-04 3.467 0 0
Nuclear Envelope Breakdown R-HSA-2980766 3.471459e-04 3.459 0 0
Co-inhibition by PD-1 R-HSA-389948 3.498219e-04 3.456 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 3.528974e-04 3.452 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.830141e-04 3.417 0 0
ISG15 antiviral mechanism R-HSA-1169408 3.832905e-04 3.416 0 0
mRNA 3'-end processing R-HSA-72187 3.879058e-04 3.411 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 3.879058e-04 3.411 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 4.050059e-04 3.393 0 0
Signaling by VEGF R-HSA-194138 4.209943e-04 3.376 0 0
TCF dependent signaling in response to WNT R-HSA-201681 4.915131e-04 3.308 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 5.167778e-04 3.287 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 5.293021e-04 3.276 0 0
Cellular response to starvation R-HSA-9711097 5.602021e-04 3.252 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 5.902587e-04 3.229 0 0
AURKA Activation by TPX2 R-HSA-8854518 5.964304e-04 3.224 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 6.019400e-04 3.220 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 6.212225e-04 3.207 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 6.212225e-04 3.207 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 6.268292e-04 3.203 0 0
MHC class II antigen presentation R-HSA-2132295 6.268292e-04 3.203 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 6.463385e-04 3.190 0 0
Gap junction assembly R-HSA-190861 6.616658e-04 3.179 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 6.856226e-04 3.164 0 0
Selenocysteine synthesis R-HSA-2408557 6.948265e-04 3.158 0 0
Developmental Biology R-HSA-1266738 6.955580e-04 3.158 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 6.989799e-04 3.156 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 7.617463e-04 3.118 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 8.836053e-04 3.054 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 8.594742e-04 3.066 0 0
Viral mRNA Translation R-HSA-192823 8.858150e-04 3.053 0 0
Meiotic recombination R-HSA-912446 8.917859e-04 3.050 0 0
Regulation of CDH1 Function R-HSA-9764561 9.254153e-04 3.034 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.282217e-04 3.032 0 0
Centrosome maturation R-HSA-380287 9.341297e-04 3.030 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 9.417826e-04 3.026 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 9.417826e-04 3.026 0 0
Muscle contraction R-HSA-397014 1.055020e-03 2.977 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.083410e-03 2.965 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.143707e-03 2.942 0 0
Smooth Muscle Contraction R-HSA-445355 1.250266e-03 2.903 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.266208e-03 2.897 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.344243e-03 2.872 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.353998e-03 2.868 0 0
Depyrimidination R-HSA-73928 1.353998e-03 2.868 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.364208e-03 2.865 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.451587e-03 2.838 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.470893e-03 2.832 0 0
Striated Muscle Contraction R-HSA-390522 1.654911e-03 2.781 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.677386e-03 2.775 0 0
Signaling by NOTCH R-HSA-157118 1.699279e-03 2.770 0 0
G1/S Transition R-HSA-69206 1.739064e-03 2.760 0 0
Cilium Assembly R-HSA-5617833 1.646256e-03 2.784 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.782391e-03 2.749 0 0
Signaling by NOTCH4 R-HSA-9013694 1.905890e-03 2.720 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.931057e-03 2.714 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.931872e-03 2.714 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.961559e-03 2.707 0 0
Gene expression (Transcription) R-HSA-74160 1.990803e-03 2.701 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 2.189210e-03 2.660 0 0
DAG and IP3 signaling R-HSA-1489509 2.289763e-03 2.640 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.453977e-03 2.610 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.573310e-03 2.590 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.573310e-03 2.590 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.614401e-03 2.583 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.614401e-03 2.583 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.727486e-03 2.564 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.759024e-03 2.559 0 0
Hedgehog 'off' state R-HSA-5610787 2.788361e-03 2.555 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 2.957834e-03 2.529 0 0
Calmodulin induced events R-HSA-111933 2.957834e-03 2.529 0 0
CaM pathway R-HSA-111997 2.957834e-03 2.529 0 0
Signaling by RAF1 mutants R-HSA-9656223 3.104870e-03 2.508 0 0
Estrogen-dependent gene expression R-HSA-9018519 3.107050e-03 2.508 0 0
Folding of actin by CCT/TriC R-HSA-390450 3.174719e-03 2.498 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 3.174719e-03 2.498 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.174719e-03 2.498 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 3.565931e-03 2.448 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 3.331397e-03 2.477 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.542415e-03 2.451 0 0
ESR-mediated signaling R-HSA-8939211 3.827664e-03 2.417 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.384191e-03 2.471 0 0
Cleavage of the damaged purine R-HSA-110331 3.542415e-03 2.451 0 0
SARS-CoV Infections R-HSA-9679506 3.844780e-03 2.415 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.999579e-03 2.398 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 4.125090e-03 2.385 0 0
Depurination R-HSA-73927 4.216720e-03 2.375 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.310298e-03 2.365 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.310298e-03 2.365 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.335991e-03 2.363 0 0
MTF1 activates gene expression R-HSA-5660489 4.335991e-03 2.363 0 0
rRNA processing R-HSA-72312 4.502144e-03 2.347 0 0
tRNA processing in the nucleus R-HSA-6784531 4.705728e-03 2.327 0 0
ER to Golgi Anterograde Transport R-HSA-199977 4.748839e-03 2.323 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 4.806376e-03 2.318 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 4.843214e-03 2.315 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.990209e-03 2.302 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 5.066376e-03 2.295 0 0
Cytokine Signaling in Immune system R-HSA-1280215 5.159679e-03 2.287 0 0
SARS-CoV-2 Infection R-HSA-9694516 5.227060e-03 2.282 0 0
Nuclear import of Rev protein R-HSA-180746 5.736968e-03 2.241 0 0
Reproduction R-HSA-1474165 5.753593e-03 2.240 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 5.872765e-03 2.231 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 5.872765e-03 2.231 0 0
MITF-M-dependent gene expression R-HSA-9856651 6.043628e-03 2.219 0 0
Clathrin-mediated endocytosis R-HSA-8856828 6.131779e-03 2.212 0 0
Co-inhibition by CTLA4 R-HSA-389513 6.443655e-03 2.191 0 0
Nephrin family interactions R-HSA-373753 6.443655e-03 2.191 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 6.531103e-03 2.185 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 6.565572e-03 2.183 0 0
Base Excision Repair R-HSA-73884 6.565572e-03 2.183 0 0
Signaling by Hedgehog R-HSA-5358351 6.734544e-03 2.172 0 0
Signaling downstream of RAS mutants R-HSA-9649948 6.799635e-03 2.168 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 6.799635e-03 2.168 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 6.799635e-03 2.168 0 0
Signaling by RAS mutants R-HSA-6802949 6.799635e-03 2.168 0 0
PKMTs methylate histone lysines R-HSA-3214841 6.874654e-03 2.163 0 0
FLT3 Signaling R-HSA-9607240 6.874654e-03 2.163 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 6.884555e-03 2.162 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 6.884555e-03 2.162 0 0
Formation of annular gap junctions R-HSA-196025 7.308463e-03 2.136 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 8.446592e-03 2.073 0 0
Long-term potentiation R-HSA-9620244 7.329115e-03 2.135 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 7.821371e-03 2.107 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 7.821371e-03 2.107 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 7.297766e-03 2.137 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 7.277756e-03 2.138 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 7.308463e-03 2.136 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 7.821371e-03 2.107 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 8.649007e-03 2.063 0 0
Organelle biogenesis and maintenance R-HSA-1852241 8.799959e-03 2.056 0 0
RNA Polymerase II Transcription R-HSA-73857 9.056747e-03 2.043 0 0
DNA Repair R-HSA-73894 9.131507e-03 2.039 0 0
Ca-dependent events R-HSA-111996 9.279107e-03 2.032 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 9.398110e-03 2.027 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 9.649504e-03 2.015 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 9.649504e-03 2.015 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 9.649504e-03 2.015 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 9.649504e-03 2.015 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 9.649504e-03 2.015 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 9.649504e-03 2.015 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 9.649504e-03 2.015 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 9.649504e-03 2.015 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 9.649504e-03 2.015 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 9.649504e-03 2.015 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 9.649504e-03 2.015 0 0
Host Interactions of HIV factors R-HSA-162909 9.690382e-03 2.014 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.831231e-03 2.007 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 9.927777e-03 2.003 0 0
Gap junction degradation R-HSA-190873 1.035561e-02 1.985 0 0
Signaling by Hippo R-HSA-2028269 1.077664e-02 1.968 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.095216e-02 1.961 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.098216e-02 1.959 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.098216e-02 1.959 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.112129e-02 1.954 0 0
Interleukin-12 signaling R-HSA-9020591 1.134643e-02 1.945 0 0
Deubiquitination R-HSA-5688426 1.145227e-02 1.941 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.159318e-02 1.936 0 0
Semaphorin interactions R-HSA-373755 1.177609e-02 1.929 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.177609e-02 1.929 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.257360e-02 1.901 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.288592e-02 1.890 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.288592e-02 1.890 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.344274e-02 1.872 0 0
Chromosome Maintenance R-HSA-73886 1.358869e-02 1.867 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.412944e-02 1.850 0 0
Signaling by WNT R-HSA-195721 1.416576e-02 1.849 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.417471e-02 1.848 0 0
Regulation of KIT signaling R-HSA-1433559 1.434487e-02 1.843 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.464186e-02 1.834 0 0
RAF activation R-HSA-5673000 1.502747e-02 1.823 0 0
MAPK family signaling cascades R-HSA-5683057 1.521435e-02 1.818 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.708910e-02 1.767 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.753699e-02 1.756 0 0
Deadenylation of mRNA R-HSA-429947 1.753699e-02 1.756 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.773121e-02 1.751 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 1.814726e-02 1.741 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.680473e-02 1.775 0 0
Oncogene Induced Senescence R-HSA-2559585 1.742333e-02 1.759 0 0
Signaling by ERBB2 R-HSA-1227986 1.775607e-02 1.751 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.884031e-02 1.725 0 0
Translation R-HSA-72766 1.699657e-02 1.770 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.743474e-02 1.759 0 0
G-protein mediated events R-HSA-112040 1.825331e-02 1.739 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.680473e-02 1.775 0 0
Nef and signal transduction R-HSA-164944 1.708910e-02 1.767 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.816708e-02 1.741 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.816708e-02 1.741 0 0
PLC beta mediated events R-HSA-112043 1.980197e-02 1.703 0 0
Amyloid fiber formation R-HSA-977225 1.869695e-02 1.728 0 0
Glycolysis R-HSA-70171 2.003919e-02 1.698 0 0
Interleukin-12 family signaling R-HSA-447115 1.870793e-02 1.728 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.008522e-02 1.697 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.008972e-02 1.697 0 0
Protein ubiquitination R-HSA-8852135 2.046207e-02 1.689 0 0
Co-stimulation by CD28 R-HSA-389356 2.050120e-02 1.688 0 0
Intraflagellar transport R-HSA-5620924 2.050120e-02 1.688 0 0
HIV Infection R-HSA-162906 2.066408e-02 1.685 0 0
Regulation of TP53 Activity R-HSA-5633007 2.082348e-02 1.681 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.090053e-02 1.680 0 0
MTOR signalling R-HSA-165159 2.183367e-02 1.661 0 0
Ion homeostasis R-HSA-5578775 2.391016e-02 1.621 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.397789e-02 1.620 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.397789e-02 1.620 0 0
Activation of RAC1 R-HSA-428540 2.441629e-02 1.612 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.441629e-02 1.612 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.460101e-02 1.609 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.467284e-02 1.608 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.587844e-02 1.587 0 0
Selenoamino acid metabolism R-HSA-2408522 2.670893e-02 1.573 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.685216e-02 1.571 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.757662e-02 1.559 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.757662e-02 1.559 0 0
Integrin signaling R-HSA-354192 2.766492e-02 1.558 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.766492e-02 1.558 0 0
Regulation of gap junction activity R-HSA-191650 2.784461e-02 1.555 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 2.784461e-02 1.555 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 2.784461e-02 1.555 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 2.784461e-02 1.555 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 2.784461e-02 1.555 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 2.784461e-02 1.555 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.784461e-02 1.555 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.863034e-02 1.543 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.863034e-02 1.543 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.863034e-02 1.543 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.885941e-02 1.540 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.885941e-02 1.540 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.885941e-02 1.540 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.980358e-02 1.526 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.986690e-02 1.525 0 0
Ub-specific processing proteases R-HSA-5689880 3.060721e-02 1.514 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 3.070975e-02 1.513 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 3.095465e-02 1.509 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 3.095465e-02 1.509 0 0
Infectious disease R-HSA-5663205 3.104928e-02 1.508 0 0
Orc1 removal from chromatin R-HSA-68949 3.221833e-02 1.492 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.264488e-02 1.486 0 0
snRNP Assembly R-HSA-191859 3.267106e-02 1.486 0 0
Metabolism of non-coding RNA R-HSA-194441 3.267106e-02 1.486 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 3.270038e-02 1.485 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.506051e-02 1.455 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.577405e-02 1.446 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 3.577405e-02 1.446 0 0
Dual Incision in GG-NER R-HSA-5696400 3.613890e-02 1.442 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.677126e-02 1.434 0 0
Synthesis of DNA R-HSA-69239 3.708207e-02 1.431 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.800928e-02 1.420 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 3.849484e-02 1.415 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 3.909570e-02 1.408 0 0
Growth hormone receptor signaling R-HSA-982772 3.983331e-02 1.400 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 4.091391e-02 1.388 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 4.218282e-02 1.375 0 0
ALK mutants bind TKIs R-HSA-9700645 4.218282e-02 1.375 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 5.354602e-02 1.271 0 0
Regulation of signaling by CBL R-HSA-912631 4.765713e-02 1.322 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 4.986113e-02 1.302 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 5.192794e-02 1.285 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.370219e-02 1.359 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 4.809083e-02 1.318 0 0
G alpha (12/13) signalling events R-HSA-416482 4.986109e-02 1.302 0 0
DNA Damage Bypass R-HSA-73893 4.811138e-02 1.318 0 0
Sema4D in semaphorin signaling R-HSA-400685 5.322200e-02 1.274 0 0
TGFBR3 expression R-HSA-9839394 5.322200e-02 1.274 0 0
Degradation of DVL R-HSA-4641258 5.192794e-02 1.285 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.105155e-02 1.292 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.105155e-02 1.292 0 0
UCH proteinases R-HSA-5689603 4.234927e-02 1.373 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 4.091391e-02 1.388 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 4.765713e-02 1.322 0 0
Unwinding of DNA R-HSA-176974 4.218282e-02 1.375 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 5.322200e-02 1.274 1 1
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 5.069446e-02 1.295 0 0
Activation of HOX genes during differentiation R-HSA-5619507 5.069446e-02 1.295 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 4.027081e-02 1.395 0 0
Telomere Maintenance R-HSA-157579 4.904321e-02 1.309 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.621793e-02 1.335 0 0
Signaling by SCF-KIT R-HSA-1433557 5.290198e-02 1.277 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 4.344301e-02 1.362 0 0
Opioid Signalling R-HSA-111885 4.734694e-02 1.325 0 0
Cellular response to chemical stress R-HSA-9711123 4.708843e-02 1.327 0 0
Generic Transcription Pathway R-HSA-212436 4.487551e-02 1.348 0 0
HCMV Late Events R-HSA-9610379 4.368922e-02 1.360 0 0
Transmission across Chemical Synapses R-HSA-112315 4.336299e-02 1.363 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.766143e-02 1.322 0 0
Signaling by PTK6 R-HSA-8848021 4.766143e-02 1.322 0 0
Neurodegenerative Diseases R-HSA-8863678 4.621793e-02 1.335 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 4.621793e-02 1.335 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 4.698285e-02 1.328 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.027081e-02 1.395 0 0
Nucleotide Excision Repair R-HSA-5696398 5.420642e-02 1.266 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 5.420642e-02 1.266 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 5.444766e-02 1.264 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 5.556901e-02 1.255 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 5.582773e-02 1.253 0 0
Adaptive Immune System R-HSA-1280218 5.599035e-02 1.252 0 0
FOXO-mediated transcription R-HSA-9614085 5.633984e-02 1.249 0 0
Diseases of mitotic cell cycle R-HSA-9675126 5.642676e-02 1.249 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.653878e-02 1.248 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.653878e-02 1.248 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.653878e-02 1.248 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 5.667433e-02 1.247 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 5.667433e-02 1.247 0 0
DCC mediated attractive signaling R-HSA-418885 5.667433e-02 1.247 0 0
RAF/MAP kinase cascade R-HSA-5673001 5.708895e-02 1.243 0 0
EPHB-mediated forward signaling R-HSA-3928662 5.861883e-02 1.232 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 5.861883e-02 1.232 0 0
Proteasome assembly R-HSA-9907900 5.861883e-02 1.232 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 6.085619e-02 1.216 0 0
G-protein beta:gamma signalling R-HSA-397795 6.351667e-02 1.197 0 0
Activation of ATR in response to replication stress R-HSA-176187 6.351667e-02 1.197 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 6.351667e-02 1.197 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 6.411782e-02 1.193 0 0
Neurexins and neuroligins R-HSA-6794361 6.411782e-02 1.193 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.411782e-02 1.193 0 0
Stabilization of p53 R-HSA-69541 6.463446e-02 1.190 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 6.472404e-02 1.189 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 6.472404e-02 1.189 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 6.472404e-02 1.189 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 6.479086e-02 1.188 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 6.479086e-02 1.188 0 0
Basigin interactions R-HSA-210991 6.479086e-02 1.188 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 6.479086e-02 1.188 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 6.575961e-02 1.182 0 0
PECAM1 interactions R-HSA-210990 6.640106e-02 1.178 0 0
HIV Life Cycle R-HSA-162587 6.660112e-02 1.177 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.732889e-02 1.172 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 6.732889e-02 1.172 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 6.912697e-02 1.160 0 0
ER-Phagosome pathway R-HSA-1236974 6.979470e-02 1.156 0 0
Diseases of cellular response to stress R-HSA-9675132 6.988616e-02 1.156 0 0
Diseases of Cellular Senescence R-HSA-9630747 6.988616e-02 1.156 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 6.988616e-02 1.156 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 6.998485e-02 1.155 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 6.998485e-02 1.155 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 7.014022e-02 1.154 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.014022e-02 1.154 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 7.113661e-02 1.148 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 7.122270e-02 1.147 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 7.166378e-02 1.145 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 7.357379e-02 1.133 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.433602e-02 1.129 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.433602e-02 1.129 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 7.454803e-02 1.128 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 7.456191e-02 1.127 0 0
CREB phosphorylation R-HSA-199920 7.456191e-02 1.127 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 7.651323e-02 1.116 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 7.901676e-02 1.102 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 7.901676e-02 1.102 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 7.901676e-02 1.102 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 7.914895e-02 1.102 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 7.928951e-02 1.101 0 0
Glucose metabolism R-HSA-70326 7.974039e-02 1.098 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.076118e-02 1.093 0 0
Protein-protein interactions at synapses R-HSA-6794362 8.330493e-02 1.079 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 8.416577e-02 1.075 0 0
mTORC1-mediated signalling R-HSA-166208 8.509414e-02 1.070 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 8.675000e-02 1.062 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 8.688261e-02 1.061 0 0
MAP2K and MAPK activation R-HSA-5674135 8.709125e-02 1.060 0 0
Late endosomal microautophagy R-HSA-9615710 8.758329e-02 1.058 0 0
Regulation of gene expression in beta cells R-HSA-210745 8.758329e-02 1.058 0 0
Drug resistance of FLT3 mutants R-HSA-9702506 1.020340e-01 0.991 0 0
FLT3 mutants bind TKIs R-HSA-9702509 1.020340e-01 0.991 0 0
tamatinib-resistant FLT3 mutants R-HSA-9703009 1.020340e-01 0.991 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.020340e-01 0.991 0 0
crenolanib-resistant FLT3 mutants R-HSA-9702581 1.020340e-01 0.991 0 0
linifanib-resistant FLT3 mutants R-HSA-9702998 1.020340e-01 0.991 0 0
lestaurtinib-resistant FLT3 mutants R-HSA-9702596 1.020340e-01 0.991 0 0
midostaurin-resistant FLT3 mutants R-HSA-9702600 1.020340e-01 0.991 0 0
sunitinib-resistant FLT3 mutants R-HSA-9702632 1.020340e-01 0.991 0 0
tandutinib-resistant FLT3 mutants R-HSA-9702636 1.020340e-01 0.991 0 0
pexidartinib-resistant FLT3 mutants R-HSA-9702605 1.020340e-01 0.991 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.020340e-01 0.991 0 0
gilteritinib-resistant FLT3 mutants R-HSA-9702590 1.020340e-01 0.991 0 0
quizartinib-resistant FLT3 mutants R-HSA-9702620 1.020340e-01 0.991 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.020340e-01 0.991 0 0
sorafenib-resistant FLT3 mutants R-HSA-9702624 1.020340e-01 0.991 0 0
KW2449-resistant FLT3 mutants R-HSA-9702569 1.020340e-01 0.991 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.020340e-01 0.991 0 0
ponatinib-resistant FLT3 mutants R-HSA-9702614 1.020340e-01 0.991 0 0
semaxanib-resistant FLT3 mutants R-HSA-9702577 1.020340e-01 0.991 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.019473e-01 0.992 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.019473e-01 0.992 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 1.019473e-01 0.992 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.019473e-01 0.992 0 0
MET activates PTPN11 R-HSA-8865999 1.019473e-01 0.992 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 9.478056e-02 1.023 0 0
Recycling of eIF2:GDP R-HSA-72731 9.478056e-02 1.023 0 0
Type I hemidesmosome assembly R-HSA-446107 1.169626e-01 0.932 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.169626e-01 0.932 0 0
MET receptor recycling R-HSA-8875656 1.169626e-01 0.932 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 1.133989e-01 0.945 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.133989e-01 0.945 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.133989e-01 0.945 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.133989e-01 0.945 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 9.171657e-02 1.038 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 9.171657e-02 1.038 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.316143e-01 0.881 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.316143e-01 0.881 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.053969e-01 0.977 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.200174e-01 0.921 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 9.776098e-02 1.010 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.213228e-01 0.916 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.213228e-01 0.916 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.719163e-02 1.012 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.185713e-01 0.926 0 0
Signaling by EGFR R-HSA-177929 9.032013e-02 1.044 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.275609e-01 0.894 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.275609e-01 0.894 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.085017e-01 0.965 0 0
Activation of the pre-replicative complex R-HSA-68962 9.776098e-02 1.010 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.199661e-01 0.921 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.275609e-01 0.894 0 0
DNA strand elongation R-HSA-69190 1.199661e-01 0.921 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 1.169626e-01 0.932 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 1.233867e-01 0.909 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 8.797542e-02 1.056 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.233867e-01 0.909 0 0
Regulation of Apoptosis R-HSA-169911 8.797542e-02 1.056 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.039599e-01 0.983 0 0
Regulation of IFNG signaling R-HSA-877312 9.639838e-02 1.016 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 9.641782e-02 1.016 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.641782e-02 1.016 0 0
Trafficking of AMPA receptors R-HSA-399719 1.085598e-01 0.964 0 0
PTEN Regulation R-HSA-6807070 1.259072e-01 0.900 0 0
Cyclin D associated events in G1 R-HSA-69231 1.136434e-01 0.944 0 0
G1 Phase R-HSA-69236 1.136434e-01 0.944 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.114946e-01 0.953 0 0
Tight junction interactions R-HSA-420029 1.213228e-01 0.916 0 0
Degradation of CDH1 R-HSA-9766229 9.310767e-02 1.031 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.169626e-01 0.932 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.133989e-01 0.945 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.310063e-01 0.883 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.200174e-01 0.921 0 0
Hedgehog ligand biogenesis R-HSA-5358346 1.096900e-01 0.960 0 0
The NLRP3 inflammasome R-HSA-844456 1.200174e-01 0.921 0 0
Antigen processing-Cross presentation R-HSA-1236975 1.040716e-01 0.983 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 9.478056e-02 1.023 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.053969e-01 0.977 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 9.548995e-02 1.020 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.169626e-01 0.932 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 1.279535e-01 0.893 0 0
Activation of BH3-only proteins R-HSA-114452 9.776098e-02 1.010 0 0
G1/S-Specific Transcription R-HSA-69205 9.719163e-02 1.012 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.319628e-01 0.880 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.319628e-01 0.880 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.319628e-01 0.880 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.335634e-01 0.874 0 0
Signaling by TGFBR3 R-HSA-9839373 1.335634e-01 0.874 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.348531e-01 0.870 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 1.355297e-01 0.868 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.355297e-01 0.868 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 1.355297e-01 0.868 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.371508e-01 0.863 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.371508e-01 0.863 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.371508e-01 0.863 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 1.371508e-01 0.863 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 1.371508e-01 0.863 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.371508e-01 0.863 0 0
Hemostasis R-HSA-109582 1.389437e-01 0.857 0 0
Glycogen metabolism R-HSA-8982491 1.392093e-01 0.856 1 0
Leishmania infection R-HSA-9658195 1.401240e-01 0.853 0 0
Parasitic Infection Pathways R-HSA-9824443 1.401240e-01 0.853 0 0
Lipophagy R-HSA-9613354 1.408594e-01 0.851 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.408594e-01 0.851 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.408594e-01 0.851 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.408594e-01 0.851 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 1.408594e-01 0.851 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.408594e-01 0.851 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.408594e-01 0.851 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.433551e-01 0.844 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.441631e-01 0.841 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 1.445292e-01 0.840 0 0
Vpu mediated degradation of CD4 R-HSA-180534 1.445292e-01 0.840 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.490600e-01 0.827 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.490600e-01 0.827 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.509410e-01 0.821 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.509410e-01 0.821 0 0
G beta:gamma signalling through BTK R-HSA-8964315 1.509410e-01 0.821 0 0
Protein methylation R-HSA-8876725 1.509410e-01 0.821 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.509410e-01 0.821 0 0
p75NTR signals via NF-kB R-HSA-193639 1.509410e-01 0.821 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.509410e-01 0.821 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.509421e-01 0.821 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 1.509421e-01 0.821 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.509421e-01 0.821 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.509801e-01 0.821 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.517608e-01 0.819 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.518789e-01 0.819 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.936624e-01 0.713 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 1.936624e-01 0.713 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.936624e-01 0.713 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.936624e-01 0.713 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.936624e-01 0.713 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.936624e-01 0.713 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 1.936624e-01 0.713 0 0
Hereditary fructose intolerance R-HSA-5657560 1.936624e-01 0.713 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 1.936624e-01 0.713 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.936624e-01 0.713 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.936624e-01 0.713 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 1.936624e-01 0.713 0 0
Defective Mismatch Repair Associated With MSH3 R-HSA-5632927 1.936624e-01 0.713 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 1.936624e-01 0.713 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.936624e-01 0.713 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 2.759459e-01 0.559 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 2.759459e-01 0.559 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.759459e-01 0.559 0 0
Defective HK1 causes hexokinase deficiency (HK deficiency) R-HSA-5619056 2.759459e-01 0.559 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 2.759459e-01 0.559 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 2.759459e-01 0.559 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 2.759459e-01 0.559 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.759459e-01 0.559 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 2.759459e-01 0.559 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 2.759459e-01 0.559 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 2.759459e-01 0.559 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 2.759459e-01 0.559 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 2.759459e-01 0.559 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.759459e-01 0.559 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.759459e-01 0.559 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 2.759459e-01 0.559 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.759459e-01 0.559 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.759459e-01 0.559 0 0
Co-inhibition by BTLA R-HSA-9927353 1.745227e-01 0.758 0 0
IRS activation R-HSA-74713 1.745227e-01 0.758 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 1.745227e-01 0.758 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 1.745227e-01 0.758 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.745227e-01 0.758 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 2.132545e-01 0.671 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 2.132545e-01 0.671 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 2.132545e-01 0.671 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.132545e-01 0.671 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 2.132545e-01 0.671 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.132545e-01 0.671 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 2.132545e-01 0.671 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.662155e-01 0.779 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.662155e-01 0.779 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.526800e-01 0.597 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 2.526800e-01 0.597 0 0
Erythropoietin activates STAT5 R-HSA-9027283 2.526800e-01 0.597 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 2.526800e-01 0.597 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 2.526800e-01 0.597 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.927768e-01 0.715 0 0
Signaling by APC mutants R-HSA-4839744 1.927768e-01 0.715 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.927768e-01 0.715 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.927768e-01 0.715 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.927768e-01 0.715 0 0
Negative regulation of FLT3 R-HSA-9706369 1.712674e-01 0.766 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 1.712674e-01 0.766 0 0
Phosphorylation of the APC/C R-HSA-176412 1.712674e-01 0.766 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.712674e-01 0.766 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 2.202957e-01 0.657 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 2.202957e-01 0.657 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.202957e-01 0.657 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.922550e-01 0.534 0 0
CHL1 interactions R-HSA-447041 2.922550e-01 0.534 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 2.922550e-01 0.534 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.922550e-01 0.534 0 0
TRIF-mediated programmed cell death R-HSA-2562578 2.922550e-01 0.534 0 0
SOS-mediated signalling R-HSA-112412 2.922550e-01 0.534 0 0
Repression of WNT target genes R-HSA-4641265 2.485361e-01 0.605 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 2.485361e-01 0.605 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 2.485361e-01 0.605 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 2.485361e-01 0.605 0 0
Pervasive developmental disorders R-HSA-9005895 2.485361e-01 0.605 0 0
Disorders of Nervous System Development R-HSA-9697154 2.485361e-01 0.605 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.485361e-01 0.605 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.485361e-01 0.605 0 0
Leading Strand Synthesis R-HSA-69109 2.485361e-01 0.605 0 0
Polymerase switching R-HSA-69091 2.485361e-01 0.605 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.485361e-01 0.605 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.485361e-01 0.605 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.485361e-01 0.605 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.485361e-01 0.605 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.690041e-01 0.772 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 1.690041e-01 0.772 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.144502e-01 0.669 0 0
FGFR2 alternative splicing R-HSA-6803529 1.868402e-01 0.729 0 0
Notch-HLH transcription pathway R-HSA-350054 1.868402e-01 0.729 0 0
CD28 dependent Vav1 pathway R-HSA-389359 2.772760e-01 0.557 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.772760e-01 0.557 0 0
GAB1 signalosome R-HSA-180292 2.370674e-01 0.625 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.370674e-01 0.625 0 0
PKA activation R-HSA-163615 2.370674e-01 0.625 0 0
PKA activation in glucagon signalling R-HSA-164378 2.370674e-01 0.625 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 2.370674e-01 0.625 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.793532e-01 0.746 0 0
Termination of translesion DNA synthesis R-HSA-5656169 1.793532e-01 0.746 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.793532e-01 0.746 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.576418e-01 0.802 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.243682e-01 0.649 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 2.602094e-01 0.585 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.602094e-01 0.585 0 0
HDMs demethylate histones R-HSA-3214842 2.439164e-01 0.613 0 0
Negative regulation of MET activity R-HSA-6807004 2.837598e-01 0.547 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.837598e-01 0.547 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.837598e-01 0.547 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.837598e-01 0.547 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.837598e-01 0.547 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.578846e-01 0.802 0 0
Dual incision in TC-NER R-HSA-6782135 1.796832e-01 0.745 0 0
Cristae formation R-HSA-8949613 2.842162e-01 0.546 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.027801e-01 0.693 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.027801e-01 0.693 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.027801e-01 0.693 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.027801e-01 0.693 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.027801e-01 0.693 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.952246e-01 0.530 0 0
Neutrophil degranulation R-HSA-6798695 1.587195e-01 0.799 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 2.638901e-01 0.579 0 0
Signaling by NOTCH1 R-HSA-1980143 2.003926e-01 0.698 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.924769e-01 0.716 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.665813e-01 0.778 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.953559e-01 0.709 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 2.149937e-01 0.668 0 0
Formation of definitive endoderm R-HSA-9823730 2.837598e-01 0.547 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.869320e-01 0.728 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.578846e-01 0.802 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.461605e-01 0.609 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 1.745227e-01 0.758 0 0
Thromboxane signalling through TP receptor R-HSA-428930 2.243682e-01 0.649 0 0
Translesion Synthesis by POLH R-HSA-110320 2.602094e-01 0.585 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 2.202957e-01 0.657 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.924769e-01 0.716 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 2.526800e-01 0.597 0 0
FLT3 signaling in disease R-HSA-9682385 1.853982e-01 0.732 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.631341e-01 0.787 0 0
RET signaling R-HSA-8853659 1.853982e-01 0.732 0 0
Leishmania phagocytosis R-HSA-9664417 2.544622e-01 0.594 0 0
Parasite infection R-HSA-9664407 2.544622e-01 0.594 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 2.544622e-01 0.594 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 3.048227e-01 0.516 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 2.922550e-01 0.534 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 2.144502e-01 0.669 0 0
GPER1 signaling R-HSA-9634597 1.551737e-01 0.809 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 2.631933e-01 0.580 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.943048e-01 0.712 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.576418e-01 0.802 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.745227e-01 0.758 0 0
NF-kB is activated and signals survival R-HSA-209560 2.202957e-01 0.657 0 0
Synaptic adhesion-like molecules R-HSA-8849932 2.370674e-01 0.625 0 0
G0 and Early G1 R-HSA-1538133 2.288456e-01 0.640 0 0
Signal amplification R-HSA-392518 1.576418e-01 0.802 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 2.908606e-01 0.536 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.650566e-01 0.782 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 2.322081e-01 0.634 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.485361e-01 0.605 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 2.302306e-01 0.638 0 0
Mitophagy R-HSA-5205647 1.576418e-01 0.802 0 0
Signaling by TGFB family members R-HSA-9006936 2.164651e-01 0.665 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.132545e-01 0.671 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 1.712744e-01 0.766 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 1.712744e-01 0.766 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.908167e-01 0.719 0 0
Degradation of CRY and PER proteins R-HSA-9932298 2.786110e-01 0.555 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.952246e-01 0.530 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 2.207665e-01 0.656 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 1.906503e-01 0.720 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 1.868402e-01 0.729 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 2.132545e-01 0.671 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.910764e-01 0.719 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 1.950280e-01 0.710 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 2.439164e-01 0.613 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 3.052111e-01 0.515 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 2.638901e-01 0.579 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 1.950280e-01 0.710 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 2.202998e-01 0.657 0 0
Rap1 signalling R-HSA-392517 2.602094e-01 0.585 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 1.888149e-01 0.724 0 0
Myogenesis R-HSA-525793 2.638901e-01 0.579 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 2.160727e-01 0.665 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.793532e-01 0.746 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 2.202998e-01 0.657 0 0
Cellular response to hypoxia R-HSA-1234174 2.653894e-01 0.576 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 1.868402e-01 0.729 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.081972e-01 0.682 0 0
Aquaporin-mediated transport R-HSA-445717 2.147788e-01 0.668 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 1.853166e-01 0.732 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 1.936624e-01 0.713 0 0
Inhibition of PKR R-HSA-169131 1.936624e-01 0.713 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.759459e-01 0.559 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.759459e-01 0.559 0 0
Manipulation of host energy metabolism R-HSA-9636667 2.759459e-01 0.559 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.202957e-01 0.657 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.202957e-01 0.657 0 0
Signaling by AXIN mutants R-HSA-4839735 2.202957e-01 0.657 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.485361e-01 0.605 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 1.639068e-01 0.785 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 1.639068e-01 0.785 0 0
Presynaptic function of Kainate receptors R-HSA-500657 2.370674e-01 0.625 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.712744e-01 0.766 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.243682e-01 0.649 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 1.853982e-01 0.732 0 0
Degradation of AXIN R-HSA-4641257 1.999822e-01 0.699 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 1.999822e-01 0.699 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.905247e-01 0.720 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 2.160727e-01 0.665 0 0
Diseases of Immune System R-HSA-5260271 2.461605e-01 0.609 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 2.461605e-01 0.609 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 2.952246e-01 0.530 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.605106e-01 0.794 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.281846e-01 0.642 0 0
Somitogenesis R-HSA-9824272 2.160727e-01 0.665 0 0
Neuronal System R-HSA-112316 2.033613e-01 0.692 0 0
Polo-like kinase mediated events R-HSA-156711 2.370674e-01 0.625 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 2.160727e-01 0.665 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 2.160727e-01 0.665 0 0
TCR signaling R-HSA-202403 2.473291e-01 0.607 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 2.242124e-01 0.649 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.160727e-01 0.665 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.002563e-01 0.698 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 2.303983e-01 0.638 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.034949e-01 0.691 0 0
Formation of paraxial mesoderm R-HSA-9793380 2.147788e-01 0.668 0 0
Generation of second messenger molecules R-HSA-202433 2.461605e-01 0.609 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.034949e-01 0.691 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.034949e-01 0.691 0 0
Signaling by NOTCH3 R-HSA-9012852 2.424130e-01 0.615 0 0
LGI-ADAM interactions R-HSA-5682910 1.927768e-01 0.715 0 0
Uptake and function of anthrax toxins R-HSA-5210891 2.144502e-01 0.669 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 1.576418e-01 0.802 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 1.576418e-01 0.802 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.027801e-01 0.693 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 2.786110e-01 0.555 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 2.786110e-01 0.555 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 2.376777e-01 0.624 0 0
Signaling by NTRKs R-HSA-166520 1.906503e-01 0.720 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 2.560998e-01 0.592 0 0
Downstream signal transduction R-HSA-186763 2.118693e-01 0.674 0 0
Interleukin-1 signaling R-HSA-9020702 1.587211e-01 0.799 0 0
Ion transport by P-type ATPases R-HSA-936837 2.523796e-01 0.598 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 2.771575e-01 0.557 0 0
Hedgehog 'on' state R-HSA-5632684 2.364466e-01 0.626 0 0
Interleukin-6 signaling R-HSA-1059683 2.772760e-01 0.557 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 2.053186e-01 0.688 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.759459e-01 0.559 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.759459e-01 0.559 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 2.288456e-01 0.640 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 2.622438e-01 0.581 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 1.950280e-01 0.710 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.606823e-01 0.584 0 0
Inflammasomes R-HSA-622312 3.048227e-01 0.516 0 0
Signaling by KIT in disease R-HSA-9669938 1.868402e-01 0.729 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 2.922550e-01 0.534 0 0
Potential therapeutics for SARS R-HSA-9679191 2.748880e-01 0.561 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.089654e-01 0.680 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.868402e-01 0.729 0 0
Specification of primordial germ cells R-HSA-9827857 2.144502e-01 0.669 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 1.745227e-01 0.758 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.132545e-01 0.671 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 2.922550e-01 0.534 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 1.927768e-01 0.715 0 0
NRAGE signals death through JNK R-HSA-193648 2.560998e-01 0.592 0 0
Response to metal ions R-HSA-5660526 1.924769e-01 0.716 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.560998e-01 0.592 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.578846e-01 0.802 0 0
Regulation of beta-cell development R-HSA-186712 1.910764e-01 0.719 0 0
Regulated Necrosis R-HSA-5218859 3.055850e-01 0.515 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.055850e-01 0.515 0 0
Malate-aspartate shuttle R-HSA-9856872 3.063093e-01 0.514 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 3.063093e-01 0.514 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 3.076062e-01 0.512 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 3.076062e-01 0.512 0 0
ERK/MAPK targets R-HSA-198753 3.076062e-01 0.512 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.081296e-01 0.511 0 0
TBC/RABGAPs R-HSA-8854214 3.120470e-01 0.506 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.193077e-01 0.496 0 0
PCP/CE pathway R-HSA-4086400 3.244342e-01 0.489 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 3.256389e-01 0.487 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 3.256389e-01 0.487 0 0
Platelet calcium homeostasis R-HSA-418360 3.256389e-01 0.487 0 0
Glucagon-type ligand receptors R-HSA-420092 3.256389e-01 0.487 0 0
MAP kinase activation R-HSA-450294 3.276952e-01 0.485 0 0
RMTs methylate histone arginines R-HSA-3214858 3.290406e-01 0.483 0 0
RSK activation R-HSA-444257 3.315386e-01 0.479 0 0
Adrenoceptors R-HSA-390696 3.315386e-01 0.479 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.315386e-01 0.479 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.315386e-01 0.479 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 3.315386e-01 0.479 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.315386e-01 0.479 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.316409e-01 0.479 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 3.331596e-01 0.477 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 3.354478e-01 0.474 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 3.354478e-01 0.474 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.354478e-01 0.474 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 3.354478e-01 0.474 0 0
Translesion synthesis by REV1 R-HSA-110312 3.354478e-01 0.474 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 3.354478e-01 0.474 0 0
Sensory processing of sound R-HSA-9659379 3.375959e-01 0.472 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.376353e-01 0.472 0 0
Gastrulation R-HSA-9758941 3.461702e-01 0.461 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.465961e-01 0.460 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 3.465961e-01 0.460 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 3.472277e-01 0.459 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.498371e-01 0.456 0 0
Signalling to ERK5 R-HSA-198765 3.498371e-01 0.456 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.498371e-01 0.456 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 3.498371e-01 0.456 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.498371e-01 0.456 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.498371e-01 0.456 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.498371e-01 0.456 0 0
C6 deamination of adenosine R-HSA-75102 3.498371e-01 0.456 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.498371e-01 0.456 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.498371e-01 0.456 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 3.498371e-01 0.456 0 0
Signaling by Interleukins R-HSA-449147 3.517088e-01 0.454 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.557619e-01 0.449 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 3.557619e-01 0.449 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 3.557619e-01 0.449 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 3.557619e-01 0.449 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 3.557619e-01 0.449 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 3.564554e-01 0.448 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 3.573680e-01 0.447 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 3.611718e-01 0.442 0 0
Translesion synthesis by POLI R-HSA-5656121 3.645208e-01 0.438 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 3.645208e-01 0.438 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 3.645208e-01 0.438 0 0
Killing mechanisms R-HSA-9664420 3.645208e-01 0.438 0 0
Activation of SMO R-HSA-5635838 3.645208e-01 0.438 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 3.645208e-01 0.438 0 0
Prolonged ERK activation events R-HSA-169893 3.645208e-01 0.438 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 3.645208e-01 0.438 0 0
Budding and maturation of HIV virion R-HSA-162588 3.676285e-01 0.435 0 0
G alpha (z) signalling events R-HSA-418597 3.684857e-01 0.434 0 0
ARMS-mediated activation R-HSA-170984 3.701784e-01 0.432 0 0
WNT mediated activation of DVL R-HSA-201688 3.701784e-01 0.432 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 3.701784e-01 0.432 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.701784e-01 0.432 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 3.701784e-01 0.432 0 0
Interleukin-1 processing R-HSA-448706 3.701784e-01 0.432 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.701784e-01 0.432 0 0
Interleukin-1 family signaling R-HSA-446652 3.751285e-01 0.426 0 0
Ca2+ pathway R-HSA-4086398 3.752927e-01 0.426 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.753429e-01 0.426 0 0
Downstream TCR signaling R-HSA-202424 3.794189e-01 0.421 0 0
Syndecan interactions R-HSA-3000170 3.798735e-01 0.420 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 3.806801e-01 0.419 0 0
Regulation of insulin secretion R-HSA-422356 3.931444e-01 0.405 0 0
Translesion synthesis by POLK R-HSA-5655862 3.933760e-01 0.405 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 3.933760e-01 0.405 0 0
Disorders of Developmental Biology R-HSA-9675151 3.933760e-01 0.405 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.933760e-01 0.405 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 3.933760e-01 0.405 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 3.933760e-01 0.405 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.933760e-01 0.405 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 3.933760e-01 0.405 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.933760e-01 0.405 0 0
Death Receptor Signaling R-HSA-73887 3.946512e-01 0.404 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 4.038865e-01 0.394 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.078970e-01 0.389 0 0
MAPK3 (ERK1) activation R-HSA-110056 4.078970e-01 0.389 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.078970e-01 0.389 0 0
2-LTR circle formation R-HSA-164843 4.078970e-01 0.389 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 4.078970e-01 0.389 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.078970e-01 0.389 0 0
Regulation of CDH11 function R-HSA-9762292 4.078970e-01 0.389 0 0
PI3K/AKT activation R-HSA-198203 4.078970e-01 0.389 0 0
Josephin domain DUBs R-HSA-5689877 4.078970e-01 0.389 0 0
Signal attenuation R-HSA-74749 4.078970e-01 0.389 0 0
Receptor Mediated Mitophagy R-HSA-8934903 4.078970e-01 0.389 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 4.078970e-01 0.389 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.078970e-01 0.389 0 0
Signaling by Leptin R-HSA-2586552 4.078970e-01 0.389 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 4.096688e-01 0.388 0 0
Unfolded Protein Response (UPR) R-HSA-381119 4.155386e-01 0.381 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 4.161914e-01 0.381 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 4.161914e-01 0.381 0 0
Axonal growth stimulation R-HSA-209563 4.161914e-01 0.381 0 0
MET interacts with TNS proteins R-HSA-8875513 4.161914e-01 0.381 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.161914e-01 0.381 0 0
MET activates STAT3 R-HSA-8875791 4.161914e-01 0.381 0 0
Histamine receptors R-HSA-390650 4.161914e-01 0.381 0 0
Interferon alpha/beta signaling R-HSA-909733 4.171078e-01 0.380 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 4.218786e-01 0.375 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 4.218786e-01 0.375 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 4.218786e-01 0.375 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 4.218786e-01 0.375 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 4.277188e-01 0.369 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 4.277188e-01 0.369 0 0
Effects of PIP2 hydrolysis R-HSA-114508 4.305604e-01 0.366 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 4.315435e-01 0.365 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.319624e-01 0.365 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 4.375590e-01 0.359 0 0
Rab regulation of trafficking R-HSA-9007101 4.400101e-01 0.357 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.444800e-01 0.352 0 0
Ionotropic activity of kainate receptors R-HSA-451306 4.444800e-01 0.352 0 0
Bicarbonate transporters R-HSA-425381 4.444800e-01 0.352 0 0
Suppression of apoptosis R-HSA-9635465 4.444800e-01 0.352 0 0
Interleukin-2 signaling R-HSA-9020558 4.444800e-01 0.352 0 0
XBP1(S) activates chaperone genes R-HSA-381038 4.450281e-01 0.352 0 0
Mismatch Repair R-HSA-5358508 4.499109e-01 0.347 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 4.499109e-01 0.347 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 4.499109e-01 0.347 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 4.499109e-01 0.347 0 0
Platelet sensitization by LDL R-HSA-432142 4.499109e-01 0.347 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 4.499109e-01 0.347 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 4.512945e-01 0.346 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 4.512945e-01 0.346 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 4.512955e-01 0.346 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.512955e-01 0.346 0 0
Platelet degranulation R-HSA-114608 4.608990e-01 0.336 0 0
Interleukin-17 signaling R-HSA-448424 4.624554e-01 0.335 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 4.645951e-01 0.333 0 0
tRNA processing R-HSA-72306 4.712709e-01 0.327 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 4.718221e-01 0.326 0 0
Signalling to ERKs R-HSA-187687 4.718221e-01 0.326 0 0
PERK regulates gene expression R-HSA-381042 4.718221e-01 0.326 0 0
Signaling by FGFR2 R-HSA-5654738 4.745081e-01 0.324 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 4.745487e-01 0.324 0 0
HCN channels R-HSA-1296061 4.757772e-01 0.323 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.757772e-01 0.323 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.757772e-01 0.323 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.757772e-01 0.323 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.757772e-01 0.323 0 0
Defective MAT1A causes MATD R-HSA-5579024 4.757772e-01 0.323 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.757772e-01 0.323 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.757772e-01 0.323 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 4.757772e-01 0.323 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.757772e-01 0.323 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 4.757772e-01 0.323 0 0
Specification of the neural plate border R-HSA-9834899 4.773718e-01 0.321 0 0
E2F mediated regulation of DNA replication R-HSA-113510 4.773718e-01 0.321 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 4.773718e-01 0.321 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 4.773718e-01 0.321 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.797665e-01 0.319 0 0
ERKs are inactivated R-HSA-202670 4.797665e-01 0.319 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.797665e-01 0.319 0 0
Integration of provirus R-HSA-162592 4.797665e-01 0.319 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 4.797665e-01 0.319 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.797665e-01 0.319 0 0
Mitochondrial protein import R-HSA-1268020 4.804151e-01 0.318 0 0
Signaling by PDGF R-HSA-186797 4.804151e-01 0.318 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 4.808517e-01 0.318 0 0
Netrin-1 signaling R-HSA-373752 4.876618e-01 0.312 0 0
GPVI-mediated activation cascade R-HSA-114604 4.920979e-01 0.308 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 4.939002e-01 0.306 0 0
Toll-like Receptor Cascades R-HSA-168898 4.946707e-01 0.306 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 4.974176e-01 0.303 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 4.974176e-01 0.303 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 5.041754e-01 0.297 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 5.041754e-01 0.297 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 5.041754e-01 0.297 0 0
Signal transduction by L1 R-HSA-445144 5.041754e-01 0.297 0 0
Protein hydroxylation R-HSA-9629569 5.041754e-01 0.297 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.120806e-01 0.291 0 0
VLDLR internalisation and degradation R-HSA-8866427 5.136401e-01 0.289 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 5.136401e-01 0.289 0 0
Signaling by LTK R-HSA-9842663 5.136401e-01 0.289 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 5.136401e-01 0.289 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.136401e-01 0.289 0 0
p75NTR recruits signalling complexes R-HSA-209543 5.136401e-01 0.289 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 5.162564e-01 0.287 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 5.198484e-01 0.284 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.198484e-01 0.284 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 5.198484e-01 0.284 0 0
DARPP-32 events R-HSA-180024 5.198484e-01 0.284 0 0
Signaling by ERBB4 R-HSA-1236394 5.213341e-01 0.283 0 0
SLC transporter disorders R-HSA-5619102 5.221675e-01 0.282 0 0
Diseases of DNA repair R-HSA-9675135 5.238075e-01 0.281 0 0
Immune System R-HSA-168256 5.246193e-01 0.280 0 0
IRE1alpha activates chaperones R-HSA-381070 5.247845e-01 0.280 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 5.292846e-01 0.276 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 5.292846e-01 0.276 0 0
G2 Phase R-HSA-68911 5.292846e-01 0.276 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.292846e-01 0.276 0 0
Activation of AKT2 R-HSA-165158 5.292846e-01 0.276 0 0
PTK6 Down-Regulation R-HSA-8849472 5.292846e-01 0.276 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.292846e-01 0.276 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 5.292846e-01 0.276 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.292846e-01 0.276 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.292846e-01 0.276 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.292846e-01 0.276 0 0
NrCAM interactions R-HSA-447038 5.292846e-01 0.276 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 5.292846e-01 0.276 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 5.292846e-01 0.276 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 5.302500e-01 0.276 0 0
Lagging Strand Synthesis R-HSA-69186 5.302500e-01 0.276 0 0
G-protein activation R-HSA-202040 5.302500e-01 0.276 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 5.302500e-01 0.276 0 0
Early Phase of HIV Life Cycle R-HSA-162594 5.302500e-01 0.276 0 0
ABC-family proteins mediated transport R-HSA-382556 5.325645e-01 0.274 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 5.414931e-01 0.266 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.417937e-01 0.266 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 5.417937e-01 0.266 0 0
Interleukin-37 signaling R-HSA-9008059 5.417937e-01 0.266 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 5.417937e-01 0.266 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 5.460217e-01 0.263 0 0
Formation of axial mesoderm R-HSA-9796292 5.460217e-01 0.263 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 5.460217e-01 0.263 0 0
Frs2-mediated activation R-HSA-170968 5.460217e-01 0.263 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 5.460217e-01 0.263 0 0
Maturation of nucleoprotein R-HSA-9683610 5.460217e-01 0.263 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 5.460217e-01 0.263 0 0
Mitochondrial biogenesis R-HSA-1592230 5.463932e-01 0.262 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 5.506105e-01 0.259 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 5.510205e-01 0.259 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 5.555373e-01 0.255 0 0
Mitochondrial calcium ion transport R-HSA-8949215 5.555373e-01 0.255 0 0
NGF-stimulated transcription R-HSA-9031628 5.588859e-01 0.253 0 0
Metal ion SLC transporters R-HSA-425410 5.588859e-01 0.253 0 0
EGFR downregulation R-HSA-182971 5.632131e-01 0.249 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 5.699141e-01 0.244 0 0
Interleukin-2 family signaling R-HSA-451927 5.699141e-01 0.244 0 0
Inositol phosphate metabolism R-HSA-1483249 5.748118e-01 0.240 0 0
Removal of the Flap Intermediate R-HSA-69166 5.768629e-01 0.239 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 5.768629e-01 0.239 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.768629e-01 0.239 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 5.768629e-01 0.239 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.768629e-01 0.239 0 0
Signal regulatory protein family interactions R-HSA-391160 5.768629e-01 0.239 0 0
Zinc transporters R-HSA-435354 5.768629e-01 0.239 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.773334e-01 0.239 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.773334e-01 0.239 0 0
Signaling by MST1 R-HSA-8852405 5.773334e-01 0.239 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 5.773334e-01 0.239 0 0
NGF-independant TRKA activation R-HSA-187024 5.773334e-01 0.239 0 0
PDE3B signalling R-HSA-165160 5.773334e-01 0.239 0 0
PKB-mediated events R-HSA-109703 5.773334e-01 0.239 0 0
Phosphorylation of Emi1 R-HSA-176417 5.773334e-01 0.239 0 0
Proton/oligopeptide cotransporters R-HSA-427975 5.773334e-01 0.239 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 5.773334e-01 0.239 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.773334e-01 0.239 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 5.773334e-01 0.239 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 5.773334e-01 0.239 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 5.773334e-01 0.239 0 0
Maturation of protein E R-HSA-9683683 5.773334e-01 0.239 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.773334e-01 0.239 0 0
Maturation of protein E R-HSA-9694493 5.773334e-01 0.239 0 0
Disorders of transmembrane transporters R-HSA-5619115 5.805157e-01 0.236 0 0
Signaling by WNT in cancer R-HSA-4791275 5.840718e-01 0.234 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 5.883270e-01 0.230 0 0
Leishmania parasite growth and survival R-HSA-9664433 5.883270e-01 0.230 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.005671e-01 0.221 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 6.035765e-01 0.219 0 0
Nuclear RNA decay R-HSA-9930044 6.043411e-01 0.219 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 6.043411e-01 0.219 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 6.043411e-01 0.219 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 6.043411e-01 0.219 0 0
Erythropoietin activates RAS R-HSA-9027284 6.061408e-01 0.217 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 6.061408e-01 0.217 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 6.061408e-01 0.217 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.061408e-01 0.217 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.061408e-01 0.217 0 0
Intra-Golgi traffic R-HSA-6811438 6.064171e-01 0.217 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 6.126265e-01 0.213 0 0
Adipogenesis R-HSA-9843745 6.163481e-01 0.210 0 0
Cardiac conduction R-HSA-5576891 6.163481e-01 0.210 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 6.182740e-01 0.209 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.204800e-01 0.207 0 0
STAT5 Activation R-HSA-9645135 6.204800e-01 0.207 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.204800e-01 0.207 0 0
Autointegration results in viral DNA circles R-HSA-177539 6.204800e-01 0.207 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 6.204800e-01 0.207 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.204800e-01 0.207 0 0
MET Receptor Activation R-HSA-6806942 6.204800e-01 0.207 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.204800e-01 0.207 0 0
Lactose synthesis R-HSA-5653890 6.204800e-01 0.207 0 0
Abacavir transmembrane transport R-HSA-2161517 6.204800e-01 0.207 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 6.204800e-01 0.207 0 0
Metabolism of vitamin K R-HSA-6806664 6.204800e-01 0.207 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 6.204800e-01 0.207 0 0
VLDL assembly R-HSA-8866423 6.204800e-01 0.207 0 0
Neurofascin interactions R-HSA-447043 6.204800e-01 0.207 0 0
Activation of GABAB receptors R-HSA-991365 6.239843e-01 0.205 0 0
GABA B receptor activation R-HSA-977444 6.239843e-01 0.205 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 6.239843e-01 0.205 0 0
Resolution of D-Loop Structures R-HSA-5693537 6.239977e-01 0.205 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 6.239977e-01 0.205 0 0
Miscellaneous transport and binding events R-HSA-5223345 6.239977e-01 0.205 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 6.262677e-01 0.203 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 6.262677e-01 0.203 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.262677e-01 0.203 0 0
Interleukin-6 family signaling R-HSA-6783589 6.262677e-01 0.203 0 0
Complex III assembly R-HSA-9865881 6.262677e-01 0.203 0 0
Circadian clock R-HSA-9909396 6.265549e-01 0.203 0 0
Developmental Cell Lineages R-HSA-9734767 6.299269e-01 0.201 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.338532e-01 0.198 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.338532e-01 0.198 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.338532e-01 0.198 0 0
Atorvastatin ADME R-HSA-9754706 6.338532e-01 0.198 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 6.338532e-01 0.198 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.338532e-01 0.198 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 6.410727e-01 0.193 0 0
Signaling by FGFR4 R-HSA-5654743 6.410727e-01 0.193 0 0
eNOS activation R-HSA-203615 6.430233e-01 0.192 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 6.430233e-01 0.192 0 0
Ion channel transport R-HSA-983712 6.448624e-01 0.191 0 0
G protein gated Potassium channels R-HSA-1296059 6.480486e-01 0.188 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 6.480486e-01 0.188 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 6.480486e-01 0.188 0 0
Acyl chain remodelling of PS R-HSA-1482801 6.480486e-01 0.188 0 0
Interleukin-7 signaling R-HSA-1266695 6.480486e-01 0.188 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 6.541498e-01 0.184 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 6.554775e-01 0.183 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 6.557575e-01 0.183 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.592245e-01 0.181 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.592245e-01 0.181 0 0
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 R-HSA-964827 6.592245e-01 0.181 0 0
Disinhibition of SNARE formation R-HSA-114516 6.592245e-01 0.181 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.592245e-01 0.181 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.592245e-01 0.181 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 6.592245e-01 0.181 0 0
Regulation of PTEN localization R-HSA-8948747 6.592245e-01 0.181 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 6.592245e-01 0.181 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 6.592245e-01 0.181 0 0
SLC-mediated transport of oligopeptides R-HSA-9959399 6.592245e-01 0.181 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 6.592245e-01 0.181 0 0
VLDL clearance R-HSA-8964046 6.592245e-01 0.181 0 0
LDL remodeling R-HSA-8964041 6.592245e-01 0.181 0 0
Activation of TRKA receptors R-HSA-187015 6.592245e-01 0.181 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.592245e-01 0.181 0 0
Netrin mediated repulsion signals R-HSA-418886 6.592245e-01 0.181 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.592245e-01 0.181 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.592245e-01 0.181 0 0
Maturation of replicase proteins R-HSA-9694301 6.592245e-01 0.181 0 0
Disease R-HSA-1643685 6.600112e-01 0.180 0 0
Passive transport by Aquaporins R-HSA-432047 6.600145e-01 0.180 0 0
Synthesis of PG R-HSA-1483148 6.600145e-01 0.180 0 0
Protein localization R-HSA-9609507 6.608210e-01 0.180 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 6.689106e-01 0.175 0 0
Metalloprotease DUBs R-HSA-5689901 6.689106e-01 0.175 0 0
TRP channels R-HSA-3295583 6.689106e-01 0.175 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 6.689106e-01 0.175 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 6.689106e-01 0.175 0 0
Signaling by FGFR3 R-HSA-5654741 6.737635e-01 0.171 0 0
Integration of energy metabolism R-HSA-163685 6.755107e-01 0.170 0 0
RUNX2 regulates bone development R-HSA-8941326 6.791318e-01 0.168 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.807982e-01 0.167 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.846527e-01 0.165 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.846527e-01 0.165 0 0
TNF signaling R-HSA-75893 6.852100e-01 0.164 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 6.888520e-01 0.162 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 6.888520e-01 0.162 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 6.888520e-01 0.162 0 0
Insulin processing R-HSA-264876 6.888520e-01 0.162 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 6.888520e-01 0.162 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 6.893480e-01 0.162 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 6.893480e-01 0.162 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 6.919185e-01 0.160 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.940156e-01 0.159 0 0
Activation of RAS in B cells R-HSA-1169092 6.940156e-01 0.159 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 6.940156e-01 0.159 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.940156e-01 0.159 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 6.940156e-01 0.159 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 6.940156e-01 0.159 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 6.940156e-01 0.159 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 6.940156e-01 0.159 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 6.940156e-01 0.159 0 0
Regulation by c-FLIP R-HSA-3371378 6.940156e-01 0.159 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 6.940156e-01 0.159 0 0
Interleukin-9 signaling R-HSA-8985947 6.940156e-01 0.159 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 6.940156e-01 0.159 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.940156e-01 0.159 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 6.940156e-01 0.159 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.940156e-01 0.159 0 0
SLC-mediated bile acid transport R-HSA-9958517 6.940156e-01 0.159 0 0
Dimerization of procaspase-8 R-HSA-69416 6.940156e-01 0.159 0 0
Sodium/Proton exchangers R-HSA-425986 6.940156e-01 0.159 0 0
Modulation by Mtb of host immune system R-HSA-9637628 6.940156e-01 0.159 0 0
Interleukin-23 signaling R-HSA-9020933 6.940156e-01 0.159 0 0
ABC transporter disorders R-HSA-5619084 7.058098e-01 0.151 0 0
Nephron development R-HSA-9831926 7.078059e-01 0.150 0 0
HIV elongation arrest and recovery R-HSA-167287 7.078772e-01 0.150 0 0
Pausing and recovery of HIV elongation R-HSA-167290 7.078772e-01 0.150 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.078772e-01 0.150 0 0
Pyroptosis R-HSA-5620971 7.078772e-01 0.150 0 0
MET promotes cell motility R-HSA-8875878 7.126081e-01 0.147 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 7.126081e-01 0.147 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 7.126081e-01 0.147 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 7.127755e-01 0.147 0 0
Gluconeogenesis R-HSA-70263 7.189702e-01 0.143 0 0
Platelet homeostasis R-HSA-418346 7.224996e-01 0.141 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 7.252566e-01 0.140 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.252566e-01 0.140 0 0
CASP8 activity is inhibited R-HSA-5218900 7.252566e-01 0.140 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 7.252566e-01 0.140 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.252566e-01 0.140 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.252566e-01 0.140 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.252566e-01 0.140 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 7.252566e-01 0.140 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.252566e-01 0.140 0 0
Interleukin-21 signaling R-HSA-9020958 7.252566e-01 0.140 0 0
mRNA Editing R-HSA-75072 7.252566e-01 0.140 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.252566e-01 0.140 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.252566e-01 0.140 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 7.252566e-01 0.140 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.252566e-01 0.140 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.252566e-01 0.140 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.252566e-01 0.140 0 0
Signaling by Erythropoietin R-HSA-9006335 7.259959e-01 0.139 0 0
Germ layer formation at gastrulation R-HSA-9754189 7.295205e-01 0.137 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 7.295205e-01 0.137 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 7.295205e-01 0.137 0 0
Other interleukin signaling R-HSA-449836 7.295205e-01 0.137 0 0
Maturation of nucleoprotein R-HSA-9694631 7.295205e-01 0.137 0 0
COPII-mediated vesicle transport R-HSA-204005 7.330243e-01 0.135 0 0
Signaling by FGFR R-HSA-190236 7.341399e-01 0.134 0 0
Metabolism of polyamines R-HSA-351202 7.386368e-01 0.132 0 0
Stimuli-sensing channels R-HSA-2672351 7.418464e-01 0.130 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.432221e-01 0.129 0 0
DAP12 signaling R-HSA-2424491 7.432221e-01 0.129 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.432221e-01 0.129 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 7.434512e-01 0.129 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.434512e-01 0.129 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.434512e-01 0.129 0 0
PI3K Cascade R-HSA-109704 7.465221e-01 0.127 0 0
Signaling by NODAL R-HSA-1181150 7.498489e-01 0.125 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 7.498489e-01 0.125 0 0
Glycogen synthesis R-HSA-3322077 7.498489e-01 0.125 0 0
Binding and entry of HIV virion R-HSA-173107 7.533096e-01 0.123 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 7.533096e-01 0.123 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.533096e-01 0.123 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.533096e-01 0.123 0 0
DNA replication initiation R-HSA-68952 7.533096e-01 0.123 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.533096e-01 0.123 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.533096e-01 0.123 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 7.533096e-01 0.123 0 0
Interleukin-27 signaling R-HSA-9020956 7.533096e-01 0.123 0 0
Maturation of spike protein R-HSA-9683686 7.533096e-01 0.123 0 0
Pexophagy R-HSA-9664873 7.533096e-01 0.123 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 7.578979e-01 0.120 0 0
Maturation of spike protein R-HSA-9694548 7.578979e-01 0.120 0 0
Cargo concentration in the ER R-HSA-5694530 7.595738e-01 0.119 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.595738e-01 0.119 0 0
Heme signaling R-HSA-9707616 7.627908e-01 0.118 0 0
NCAM signaling for neurite out-growth R-HSA-375165 7.627908e-01 0.118 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 7.688477e-01 0.114 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.688477e-01 0.114 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.688477e-01 0.114 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.688477e-01 0.114 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 7.688477e-01 0.114 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.688477e-01 0.114 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 7.688477e-01 0.114 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 7.717064e-01 0.113 0 0
HIV Transcription Initiation R-HSA-167161 7.717064e-01 0.113 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 7.717064e-01 0.113 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.717064e-01 0.113 0 0
Signaling by FGFR1 in disease R-HSA-5655302 7.717064e-01 0.113 0 0
Translation of Structural Proteins R-HSA-9683701 7.717064e-01 0.113 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 7.720219e-01 0.112 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.747840e-01 0.111 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.750719e-01 0.111 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 7.750719e-01 0.111 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 7.784996e-01 0.109 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.784996e-01 0.109 0 0
vRNA Synthesis R-HSA-192814 7.784996e-01 0.109 0 0
vRNP Assembly R-HSA-192905 7.784996e-01 0.109 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 7.784996e-01 0.109 0 0
Chylomicron assembly R-HSA-8963888 7.784996e-01 0.109 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.784996e-01 0.109 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.784996e-01 0.109 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.784996e-01 0.109 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 7.840150e-01 0.106 0 0
Nucleotide biosynthesis R-HSA-8956320 7.840150e-01 0.106 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 7.855258e-01 0.105 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.865765e-01 0.104 0 0
Assembly Of The HIV Virion R-HSA-175474 7.865765e-01 0.104 0 0
Ribavirin ADME R-HSA-9755088 7.865765e-01 0.104 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 7.865765e-01 0.104 0 0
FGFR1 mutant receptor activation R-HSA-1839124 7.897400e-01 0.103 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.974556e-01 0.098 0 0
Response of Mtb to phagocytosis R-HSA-9637690 7.974556e-01 0.098 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 8.000738e-01 0.097 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 8.011188e-01 0.096 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.011188e-01 0.096 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.011188e-01 0.096 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.011188e-01 0.096 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.011188e-01 0.096 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.011188e-01 0.096 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 8.011188e-01 0.096 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.011188e-01 0.096 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.011188e-01 0.096 0 0
Sodium/Calcium exchangers R-HSA-425561 8.011188e-01 0.096 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.030963e-01 0.095 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 8.030963e-01 0.095 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.030963e-01 0.095 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 8.030963e-01 0.095 0 0
Cellular hexose transport R-HSA-189200 8.030963e-01 0.095 0 0
LDL clearance R-HSA-8964038 8.030963e-01 0.095 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 8.036036e-01 0.095 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 8.036036e-01 0.095 0 0
Translation of Structural Proteins R-HSA-9694635 8.070631e-01 0.093 0 0
Amine ligand-binding receptors R-HSA-375280 8.094236e-01 0.092 0 0
Signaling by NOTCH2 R-HSA-1980145 8.166902e-01 0.088 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.166902e-01 0.088 0 0
Signaling by FGFR1 R-HSA-5654736 8.170611e-01 0.088 0 0
Interleukin receptor SHC signaling R-HSA-912526 8.184693e-01 0.087 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.208078e-01 0.086 0 0
MET activates RAS signaling R-HSA-8851805 8.214294e-01 0.085 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.214294e-01 0.085 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.214294e-01 0.085 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.214294e-01 0.085 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.214294e-01 0.085 0 0
Acetylation R-HSA-156582 8.214294e-01 0.085 0 0
Interleukin-35 Signalling R-HSA-8984722 8.214294e-01 0.085 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 8.214294e-01 0.085 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.214294e-01 0.085 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.214294e-01 0.085 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.214294e-01 0.085 0 0
Synthesis of GDP-mannose R-HSA-446205 8.214294e-01 0.085 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.214294e-01 0.085 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 8.214294e-01 0.085 0 0
Estrogen biosynthesis R-HSA-193144 8.214294e-01 0.085 0 0
OAS antiviral response R-HSA-8983711 8.214294e-01 0.085 0 0
Transcription of the HIV genome R-HSA-167172 8.252676e-01 0.083 0 0
IRS-mediated signalling R-HSA-112399 8.271308e-01 0.082 0 0
Post-translational protein phosphorylation R-HSA-8957275 8.274181e-01 0.082 0 0
Regulation of TNFR1 signaling R-HSA-5357905 8.316247e-01 0.080 0 0
Signaling by MET R-HSA-6806834 8.335207e-01 0.079 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.367459e-01 0.077 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.396668e-01 0.076 0 0
Processing of SMDT1 R-HSA-8949664 8.396668e-01 0.076 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.396668e-01 0.076 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.396668e-01 0.076 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.396668e-01 0.076 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.406462e-01 0.075 0 0
RNA Polymerase III Transcription R-HSA-74158 8.406462e-01 0.075 0 0
Glycosphingolipid transport R-HSA-9845576 8.406462e-01 0.075 0 0
Extension of Telomeres R-HSA-180786 8.459183e-01 0.073 0 0
Amino acid transport across the plasma membrane R-HSA-352230 8.459183e-01 0.073 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.460215e-01 0.073 0 0
GABA receptor activation R-HSA-977443 8.546603e-01 0.068 0 0
tRNA Aminoacylation R-HSA-379724 8.546603e-01 0.068 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.560426e-01 0.068 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.560426e-01 0.068 0 0
CRMPs in Sema3A signaling R-HSA-399956 8.560426e-01 0.068 0 0
N-glycan trimming and elongation in the cis-Golgi R-HSA-964739 8.560426e-01 0.068 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.560426e-01 0.068 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.560426e-01 0.068 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.560426e-01 0.068 0 0
Signaling by FGFR4 in disease R-HSA-5655291 8.560426e-01 0.068 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.560426e-01 0.068 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.560426e-01 0.068 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.570178e-01 0.067 0 0
MET activates PTK2 signaling R-HSA-8874081 8.583220e-01 0.066 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 8.583220e-01 0.066 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.629849e-01 0.064 0 0
FCGR activation R-HSA-2029481 8.630220e-01 0.064 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.689236e-01 0.061 0 0
Azathioprine ADME R-HSA-9748787 8.695764e-01 0.061 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.697171e-01 0.061 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 8.697171e-01 0.061 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 8.697171e-01 0.061 0 0
Signaling by BMP R-HSA-201451 8.697171e-01 0.061 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.697171e-01 0.061 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.707467e-01 0.060 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.707467e-01 0.060 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.707467e-01 0.060 0 0
Signaling by Activin R-HSA-1502540 8.707467e-01 0.060 0 0
p38MAPK events R-HSA-171007 8.707467e-01 0.060 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.707467e-01 0.060 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.707467e-01 0.060 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.707467e-01 0.060 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.714829e-01 0.060 0 0
Pentose phosphate pathway R-HSA-71336 8.714829e-01 0.060 0 0
Signaling by ALK R-HSA-201556 8.714829e-01 0.060 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.714829e-01 0.060 0 0
Prednisone ADME R-HSA-9757110 8.802635e-01 0.055 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 8.805222e-01 0.055 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.839497e-01 0.054 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.839497e-01 0.054 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 8.839497e-01 0.054 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.839497e-01 0.054 0 0
Fructose catabolism R-HSA-70350 8.839497e-01 0.054 0 0
Differentiation of T cells R-HSA-9945266 8.839497e-01 0.054 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.839497e-01 0.054 0 0
Regulation of BACH1 activity R-HSA-9708530 8.839497e-01 0.054 0 0
Attachment and Entry R-HSA-9678110 8.839497e-01 0.054 0 0
IGF1R signaling cascade R-HSA-2428924 8.855859e-01 0.053 0 0
Insulin receptor signalling cascade R-HSA-74751 8.855859e-01 0.053 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.856236e-01 0.053 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 8.859090e-01 0.053 0 0
FCERI mediated NF-kB activation R-HSA-2871837 8.866945e-01 0.052 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.923736e-01 0.049 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.929815e-01 0.049 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.958047e-01 0.048 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 8.958047e-01 0.048 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 8.958047e-01 0.048 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 8.958047e-01 0.048 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 8.958047e-01 0.048 0 0
Galactose catabolism R-HSA-70370 8.958047e-01 0.048 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 8.958047e-01 0.048 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.958047e-01 0.048 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.958329e-01 0.048 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 8.988110e-01 0.046 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.990256e-01 0.046 0 0
Nuclear Receptor transcription pathway R-HSA-383280 8.995716e-01 0.046 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.000874e-01 0.046 0 0
Neddylation R-HSA-8951664 9.028184e-01 0.044 0 0
Interferon gamma signaling R-HSA-877300 9.046709e-01 0.044 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.049115e-01 0.043 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.064493e-01 0.043 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.064493e-01 0.043 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.064493e-01 0.043 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.064493e-01 0.043 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.064493e-01 0.043 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.064493e-01 0.043 0 0
Choline catabolism R-HSA-6798163 9.064493e-01 0.043 0 0
Glycogen storage diseases R-HSA-3229121 9.064493e-01 0.043 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.064493e-01 0.043 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.073433e-01 0.042 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.160071e-01 0.038 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 9.160071e-01 0.038 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.160071e-01 0.038 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.160071e-01 0.038 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 9.160071e-01 0.038 0 0
Apoptotic factor-mediated response R-HSA-111471 9.160071e-01 0.038 0 0
DAP12 interactions R-HSA-2172127 9.177300e-01 0.037 0 0
Surfactant metabolism R-HSA-5683826 9.177300e-01 0.037 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.197790e-01 0.036 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.210992e-01 0.036 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 9.220889e-01 0.035 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.245888e-01 0.034 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.245888e-01 0.034 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 9.245888e-01 0.034 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.245888e-01 0.034 0 0
Pyrimidine biosynthesis R-HSA-500753 9.245888e-01 0.034 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.245888e-01 0.034 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.245888e-01 0.034 0 0
Formation of the cornified envelope R-HSA-6809371 9.260522e-01 0.033 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.278673e-01 0.033 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.286041e-01 0.032 0 0
Peroxisomal protein import R-HSA-9033241 9.289744e-01 0.032 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.289744e-01 0.032 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.293938e-01 0.032 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.293938e-01 0.032 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.308250e-01 0.031 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.322942e-01 0.030 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.322942e-01 0.030 0 0
Creatine metabolism R-HSA-71288 9.322942e-01 0.030 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.322942e-01 0.030 0 0
Pregnenolone biosynthesis R-HSA-196108 9.322942e-01 0.030 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.337794e-01 0.030 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.346019e-01 0.029 0 0
NOD1/2 Signaling Pathway R-HSA-168638 9.346019e-01 0.029 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.346019e-01 0.029 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.346019e-01 0.029 0 0
Signalling to RAS R-HSA-167044 9.392126e-01 0.027 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.392126e-01 0.027 0 0
Signaling by FGFR in disease R-HSA-1226099 9.392871e-01 0.027 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.401199e-01 0.027 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.425153e-01 0.026 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.427369e-01 0.026 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.440613e-01 0.025 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.440613e-01 0.025 0 0
Triglyceride catabolism R-HSA-163560 9.451935e-01 0.024 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.454245e-01 0.024 0 0
Attachment and Entry R-HSA-9694614 9.454245e-01 0.024 0 0
G alpha (s) signalling events R-HSA-418555 9.461138e-01 0.024 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.464767e-01 0.024 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.482850e-01 0.023 0 0
Voltage gated Potassium channels R-HSA-1296072 9.498559e-01 0.022 0 0
Metabolism of folate and pterines R-HSA-196757 9.498559e-01 0.022 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.501867e-01 0.022 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.502407e-01 0.022 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.510019e-01 0.022 0 0
Fructose metabolism R-HSA-5652084 9.510019e-01 0.022 0 0
Ethanol oxidation R-HSA-71384 9.510019e-01 0.022 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 9.510019e-01 0.022 0 0
The phototransduction cascade R-HSA-2514856 9.522100e-01 0.021 0 0
Integrin cell surface interactions R-HSA-216083 9.534723e-01 0.021 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.534723e-01 0.021 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.541358e-01 0.020 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.560096e-01 0.020 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.560096e-01 0.020 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.560096e-01 0.020 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.560096e-01 0.020 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.560096e-01 0.020 0 0
Interleukin-20 family signaling R-HSA-8854691 9.560096e-01 0.020 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.560096e-01 0.020 0 0
Biosynthesis of maresins R-HSA-9018682 9.560096e-01 0.020 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.565116e-01 0.019 0 0
G alpha (q) signalling events R-HSA-416476 9.568440e-01 0.019 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 9.580692e-01 0.019 0 0
RAS processing R-HSA-9648002 9.580692e-01 0.019 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.605058e-01 0.017 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.605058e-01 0.017 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.605058e-01 0.017 0 0
Metabolism of proteins R-HSA-392499 9.610316e-01 0.017 0 0
HIV Transcription Elongation R-HSA-167169 9.616761e-01 0.017 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 9.616761e-01 0.017 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.616761e-01 0.017 0 0
Post-translational protein modification R-HSA-597592 9.620901e-01 0.017 0 0
Signaling by Insulin receptor R-HSA-74752 9.623954e-01 0.017 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.645427e-01 0.016 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.645427e-01 0.016 0 0
Hyaluronan degradation R-HSA-2160916 9.645427e-01 0.016 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.645427e-01 0.016 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.645427e-01 0.016 0 0
Laminin interactions R-HSA-3000157 9.645427e-01 0.016 0 0
RSV-host interactions R-HSA-9833110 9.655776e-01 0.015 0 0
Innate Immune System R-HSA-168249 9.664448e-01 0.015 0 0
Mitochondrial protein degradation R-HSA-9837999 9.669771e-01 0.015 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.680163e-01 0.014 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.681672e-01 0.014 0 0
Urea cycle R-HSA-70635 9.681672e-01 0.014 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.681672e-01 0.014 0 0
Sphingolipid catabolism R-HSA-9845614 9.681672e-01 0.014 0 0
Abacavir ADME R-HSA-2161522 9.681672e-01 0.014 0 0
Dectin-2 family R-HSA-5621480 9.704840e-01 0.013 0 0
Synthesis of PA R-HSA-1483166 9.704840e-01 0.013 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.714213e-01 0.013 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.714213e-01 0.013 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.714213e-01 0.013 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.714213e-01 0.013 0 0
Potassium Channels R-HSA-1296071 9.728967e-01 0.012 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 9.743430e-01 0.011 0 0
Formation of the Early Elongation Complex R-HSA-113418 9.743430e-01 0.011 0 0
Telomere Extension By Telomerase R-HSA-171319 9.743430e-01 0.011 0 0
Insulin receptor recycling R-HSA-77387 9.743430e-01 0.011 0 0
Pyrimidine salvage R-HSA-73614 9.743430e-01 0.011 0 0
Methylation R-HSA-156581 9.756698e-01 0.011 0 0
Pyruvate metabolism R-HSA-70268 9.767214e-01 0.010 0 0
mRNA Capping R-HSA-72086 9.769661e-01 0.010 0 0
Thyroxine biosynthesis R-HSA-209968 9.769661e-01 0.010 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.769661e-01 0.010 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.778023e-01 0.010 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.779767e-01 0.010 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.793212e-01 0.009 0 0
Neurotransmitter clearance R-HSA-112311 9.793212e-01 0.009 0 0
Neurotransmitter release cycle R-HSA-112310 9.812177e-01 0.008 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.812177e-01 0.008 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.814356e-01 0.008 0 0
Cardiogenesis R-HSA-9733709 9.850383e-01 0.007 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.850383e-01 0.007 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.860212e-01 0.006 0 0
Collagen formation R-HSA-1474290 9.869491e-01 0.006 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.879421e-01 0.005 0 0
Hyaluronan metabolism R-HSA-2142845 9.879421e-01 0.005 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.879421e-01 0.005 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.884009e-01 0.005 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.891754e-01 0.005 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.891754e-01 0.005 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.891754e-01 0.005 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.891754e-01 0.005 0 0
Extracellular matrix organization R-HSA-1474244 9.893769e-01 0.005 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.895477e-01 0.005 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.902826e-01 0.004 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.902826e-01 0.004 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.912766e-01 0.004 0 0
NCAM1 interactions R-HSA-419037 9.912766e-01 0.004 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.912766e-01 0.004 0 0
Collagen chain trimerization R-HSA-8948216 9.912766e-01 0.004 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.913687e-01 0.004 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.916185e-01 0.004 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.921690e-01 0.003 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.921690e-01 0.003 0 0
Aspirin ADME R-HSA-9749641 9.922922e-01 0.003 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.929702e-01 0.003 0 0
Iron uptake and transport R-HSA-917937 9.935149e-01 0.003 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.936894e-01 0.003 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.936894e-01 0.003 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.938913e-01 0.003 0 0
Triglyceride metabolism R-HSA-8979227 9.940029e-01 0.003 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.941570e-01 0.003 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.943351e-01 0.002 0 0
RAB geranylgeranylation R-HSA-8873719 9.945464e-01 0.002 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.949147e-01 0.002 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.949147e-01 0.002 0 0
Collagen degradation R-HSA-1442490 9.950414e-01 0.002 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.950937e-01 0.002 0 0
Transport of small molecules R-HSA-382551 9.954304e-01 0.002 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.954351e-01 0.002 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.958656e-01 0.002 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.960501e-01 0.002 1 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.963216e-01 0.002 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.966981e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.972081e-01 0.001 0 0
Kidney development R-HSA-9830369 9.972081e-01 0.001 0 0
Synthesis of PC R-HSA-1483191 9.973394e-01 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 9.974644e-01 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.974644e-01 0.001 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.976118e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.978563e-01 0.001 0 0
PI Metabolism R-HSA-1483255 9.980266e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.981020e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.981020e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.981020e-01 0.001 0 0
PPARA activates gene expression R-HSA-1989781 9.981357e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.982727e-01 0.001 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.982727e-01 0.001 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.984364e-01 0.001 0 0
G alpha (i) signalling events R-HSA-418594 9.984974e-01 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.985811e-01 0.001 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.987125e-01 0.001 0 0
Paracetamol ADME R-HSA-9753281 9.988788e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.989936e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.992491e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.994137e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.994661e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.995277e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.995761e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.995774e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.995943e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.996027e-01 0.000 0 0
Classical antibody-mediated complement activation R-HSA-173623 9.996738e-01 0.000 0 0
Keratinization R-HSA-6805567 9.996783e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.997021e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.997784e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.997956e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.998562e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.998664e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.998953e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999004e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999074e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999163e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999326e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999326e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999528e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999552e-01 0.000 0 0
Creation of C4 and C2 activators R-HSA-166786 9.999598e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999757e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999809e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.999838e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999846e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999867e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999904e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999905e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999923e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999931e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999941e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999946e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999952e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999954e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999955e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999960e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999963e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999964e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999968e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999979e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999979e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999979e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999980e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999981e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999990e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999996e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999996e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999999e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999999e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999999e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 1 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways