DYRK1A

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0MZ66 S493 Sugiyama SHTN1 KIAA1598 sEtELERILRRRKVtAEADsssPtGILAtsEsKsMPVLGsV
O00115 S70 Sugiyama DNASE2 DNASE2A DNL2 QYKyLDEssGGWRDGRALINsPEGAVGRSLQPLyRSNTSQL
O00151 S90 Sugiyama PDLIM1 CLIM1 CLP36 IKGCTDNLtLtVARsEHKVWsPLVtEEGKRHPYKMNLASEP
O00178 S12 Sugiyama GTPBP1 _________MATERsRsAMDsPVPAsMFAPEPssPGAARAA
O00178 S6 Sugiyama GTPBP1 _______________MATERsRsAMDsPVPAsMFAPEPssP
O00178 S8 Sugiyama GTPBP1 _____________MATERsRsAMDsPVPAsMFAPEPssPGA
O00193 S17 Sugiyama SMAP C11orf58 ____MsAARESHPHGVKRsAsPDDDLGssNWEAADLGNEER
O00193 S25 Sugiyama SMAP C11orf58 RESHPHGVKRsAsPDDDLGssNWEAADLGNEERKQKFLRLM
O00264 S54 Sugiyama PGRMC1 HPR6.6 PGRMC LLGLCIFLLYKIVRGDQPAAsGDsDDDEPPPLPRLKRRDFt
O00264 S57 Sugiyama PGRMC1 HPR6.6 PGRMC LCIFLLYKIVRGDQPAAsGDsDDDEPPPLPRLKRRDFtPAE
O00429 S126 Sugiyama DNM1L DLP1 DRP1 EIRQEIENETERISGNNKGVsPEPIHLKIFSPNVVNLTLVD
O14545 S327 Sugiyama TRAFD1 FLN29 DHQTSCNPSRALPsLNtGsssPRGVEEPDVIFQNFLQQAAS
O14639 S431 Sugiyama ABLIM1 ABLIM KIAA0059 LIMAB1 TSGYDDKQERQsLGEsPRtLsPtPsAEGyQDVRDRMIHRst
O14639 T433 Sugiyama ABLIM1 ABLIM KIAA0059 LIMAB1 GYDDKQERQsLGEsPRtLsPtPsAEGyQDVRDRMIHRstsQ
O15047 S470 Sugiyama SETD1A KIAA0339 KMT2F SET1 SET1A sPEREEVRtsPRPAsPARsGsPAPEttNESVPFAQHSSLDS
O15061 S1044 Sugiyama SYNM DMN KIAA0353 SYN ASEMEKAVESVVREsLsRQRsPAPGsPDEEGGAEAPAAGIR
O43524 S330 SIGNOR FOXO3 FKHRL1 FOXO3A RsRTNsNAsTVsGRLSPIMAsTELDEVQDDDAPLsPMLYSS
O43597 T75 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP SPRY2 ytEGPTVVPRPGLKPAPRPStQHKHERLHGLPEHRQPPRLQ
O60664 S175 Sugiyama PLIN3 M6PRBP1 TIP47 RGAVQSGVDKTKsVVtGGVQsVMGsRLGQMVLsGVDtVLGK
O60716 S252 Sugiyama CTNND1 KIAA0384 sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O75179 S2401 Sugiyama ANKRD17 GTAR KIAA0697 CSSASNDSSAQSVSSGVRAPsPAPssVPLGSEKPSNVSQDR
O75533 T273 EPSD|PSP SF3B1 SAP155 IWDPtPsHtPAGAAtPGRGDtPGHAtPGHGGAtssARKNRW
O75533 T434 GPS6|SIGNOR|iPTMNet|EPSD|PSP SF3B1 SAP155 VLPPPAGYVPIRtPARKLtAtPtPLGGMtGFHMQTEDRTMK
O76039 S308 EPSD|PSP CDKL5 STK9 TEQCLNHPTFQTQRLLDRsPsRSAKRKPYHVESSTLSNRNQ
O94826 S91 Sugiyama TOMM70 KIAA0719 TOM70 TOMM70A RGDASGLKRNSERKtPEGRAsPAPGsGHPEGPGAHLDMNsL
O94826 S96 Sugiyama TOMM70 KIAA0719 TOM70 TOMM70A GLKRNSERKtPEGRAsPAPGsGHPEGPGAHLDMNsLDRAQA
O94842 S178 Sugiyama TOX4 C14orf92 KIAA0737 GGGTILPPAQSPEDRLsttPsPtssLHEDGVEDFRRQLPSQ
O94842 T176 Sugiyama TOX4 C14orf92 KIAA0737 SLGGGTILPPAQSPEDRLsttPsPtssLHEDGVEDFRRQLP
O94979 S799 Sugiyama SEC31A KIAA0905 SEC31L1 HSPC275 HSPC334 IMQLRDRLCRAQGEPVAGHEsPKIPyEKQQLPKGRPGPVAG
O95359 S2512 Sugiyama TACC2 KQDYPQPSDLSTFVNETKFssPtEELDyRNsYEIEyMEKIG
O95644 S261 EPSD|PSP NFATC1 NFAT2 NFATC sPRAsVTEESWLGARssRPAsPCNKRKYsLNGRQPPysPHH
O95644 S278 EPSD|PSP NFATC1 NFAT2 NFATC RPAsPCNKRKYsLNGRQPPysPHHsPtPSPHGsPRVsVTDD
O95644 S403 EPSD|PSP NFATC1 NFAT2 NFATC CDQYLAVPQHPYQWAKPKPLsPTSYMsPTLPALDWQLPSHS
O95644 S409 EPSD|PSP NFATC1 NFAT2 NFATC VPQHPYQWAKPKPLsPTSYMsPTLPALDWQLPSHSGPYELR
O95817 S173 Sugiyama BAG3 BIS QVAAAAAAQPPAsHGPERsQsPAAsDCsssSsSAsLPssGR
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04637 S15 SIGNOR|EPSD|PSP TP53 P53 ______MEEPQsDPsVEPPLsQEtFsDLWKLLPENNVLsPL
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04920 S172 Sugiyama SLC4A2 AE2 EPB3L1 HKB3 MPB3L VQFFLQEDDSADRKAERtsPssPAPLPHQEAtPRASKGAQA
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195 S320 Sugiyama LDHB GLtsVINQKLKDDEVAQLKKsADtLWDIQKDLKDL______
P07814 T737 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 EKTKVEATKNETSAPFKERPtPsLNNNCttsEDsLVLyNRV
P07942 T1141 Sugiyama LAMB1 FWGDPDVECRACDCDPRGIEtPQCDQSTGQCVCVEGVEGPR
P08151 S408 EPSD|PSP GLI1 GLI GPDAHVtKRHRGDGPLPRAPsISTVEPKREREGGPIREESR
P08195 S607 Sugiyama SLC3A2 MDU1 ASLPAKADLLLstQPGREEGsPLELERLKLEPHEGLLLRFP
P08238 S45 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P10636 S519 SIGNOR MAPT MAPTL MTBT1 TAU PPsSGEPPKsGDRsGyssPGsPGtPGsRsRtPsLPtPPTRE
P10636 S721 SIGNOR MAPT MAPTL MTBT1 TAU AKTDHGAEIVyKsPVVsGDtsPRHLsNVsstGsIDMVDsPQ
P10636 T529 SIGNOR MAPT MAPTL MTBT1 TAU GDRsGyssPGsPGtPGsRsRtPsLPtPPTREPKKVAVVRtP
P10809 S70 Sugiyama HSPD1 HSP60 AVAVTMGPKGRtVIIEQsWGsPKVTKDGVtVAKsIDLKDKY
P11142 T38 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P12270 S652 Sugiyama TPR sLDDVsLAstPKRPstsQtVstPAPVPVIESTEAIEAKAAL
P12270 T650 Sugiyama TPR AssLDDVsLAstPKRPstsQtVstPAPVPVIESTEAIEAKA
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 S595 Sugiyama EEF2 EF2 PVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGLAE
P13804 S192 Sugiyama ETFA sFDAAATsGGsASsEKAsStsPVEIsEWLDQKLTKSDRPEL
P13807 S641 SIGNOR GYS1 GYS FTYEPNEADAAQGyRyPRPAsVPPsPsLsRHssPHQsEDEE
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14625 S106 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14866 S101 Sugiyama HNRNPL HNRPL P/OKcl.14 GAAGGGGGGENyDDPHKtPAsPVVHIRGLIDGVVEADLVEA
P15559 S82 Sugiyama NQO1 DIA4 NMOR1 DPANFQYPAESVLAYKEGHLsPDIVAEQKKLEAADLVIFQF
P17066 T40 Sugiyama HSPA6 HSP70B' VGVFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQ
P17812 S573 Sugiyama CTPS1 CTPS HYLQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD__
P17812 S575 Sugiyama CTPS1 CTPS LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P17980 S376 Sugiyama PSMC3 TBP1 MPNEEARARIMQIHSRKMNVsPDVNyEELARCTDDFNGAQC
P18827 S233 Sugiyama SDC1 SDC FETSGENTAVVAVEPDRRNQsPVDQGAtGAsQGLLDRKEVL
P21333 S1084 Sugiyama FLNA FLN FLN1 PTKPSKVKAFGPGLQGGsAGsPARFtIDTKGAGTGGLGLTV
P22234 S27 Sugiyama PAICS ADE2 AIRC PAIS LNIGKKLYEGKtKEVyELLDsPGKVLLQsKDQItAGNAARK
P22626 S189 Sugiyama HNRNPA2B1 HNRPA2B1 IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P22626 S212 Sugiyama HNRNPA2B1 HNRPA2B1 EMQEVQssRsGRGGNFGFGDsRGGGGNFGPGPGsNFRGGsD
P23396 T221 Sugiyama RPS3 OK/SW-cl.26 KKPLPDHVsIVEPKDEILPttPIsEQKGGKPEPPAMPQPVP
P23588 S207 Sugiyama EIF4B DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P23588 T205 Sugiyama EIF4B GRDRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYR
P24385 T286 SIGNOR|EPSD|PSP CCND1 BCL1 PRAD1 MDPKAAEEEEEEEEEVDLACtPtDVRDVDI___________
P24928 S1616 EPSD|PSP POLR2A POLR2 TSPAYEPRSPGGYTPQSPSysPtsPsYsPTsPSYSPTSPNY
P24928 S1619 EPSD|PSP POLR2A POLR2 AYEPRSPGGYTPQSPSysPtsPsYsPTsPSYSPTSPNYSPT
P25398 Y127 Sugiyama RPS12 sCVVVKDYGKESQAKDVIEEyFKCKK_______________
P25786 S14 Sugiyama PSMA1 HC2 NU PROS30 PSC2 _______MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQGSA
P25789 S13 Sugiyama PSMA4 HC9 PSC9 ________MSRRyDsRttIFsPEGRLYQVEYAMEAIGHAGT
P25789 T9 Sugiyama PSMA4 HC9 PSC9 ____________MSRRyDsRttIFsPEGRLYQVEYAMEAIG
P27348 S45 Sugiyama YWHAQ CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27824 S362 Sugiyama CANX WDEDMDGEWEAPQIANPRCEsAPGCGVWQRPVIDNPNyKGK
P29401 S295 Sugiyama TKT ysQIQsKKKILAtPPQEDAPsVDIANIRMPsLPsyKVGDKI
P29401 T287 Sugiyama TKT AEQIIQEIysQIQsKKKILAtPPQEDAPsVDIANIRMPsLP
P29692 S44 Sugiyama EEF1D EF1D RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P30041 T44 Sugiyama PRDX6 AOP2 KIAA0106 RFHDFLGDSWGILFSHPRDFtPVCttELGRAAKLAPEFAKR
P30086 T51 Sugiyama PEBP1 PBP PEBP GAAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDP
P30101 T485 Sugiyama PDIA3 ERP57 ERP60 GRP58 KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P31943 S104 Sugiyama HNRNPH1 HNRPH HNRPH1 EVFKSNNVEMDWVLKHtGPNsPDtANDGFVRLRGLPFGCSK
P31946 S47 Sugiyama YWHAB AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947 S45 Sugiyama SFN HME1 FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P34931 T40 Sugiyama HSPA1L VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P35251 S1088 Sugiyama RFC1 RFC140 KEAHLtPYsLQAIKASRHstsPSLDsEyNEELNEDDsQsDE
P35269 T389 Sugiyama GTF2F1 RAP74 PPKRERKPsGGSSRGNsRPGtPsAEGGstsstLRAAASKLE
P35613 S278 Sugiyama BSG UNQ6505/PRO21383 ITDSEDKALMNGSESRFFVsssQGRSELHIENLNMEADPGQ
P35998 T193 Sugiyama PSMC2 MSS1 TYSDVGGCKEQIEKLREVVEtPLLHPERFVNLGIEPPKGVL
P36578 S295 Sugiyama RPL4 RPL1 sNyNLPMHKMINtDLsRILKsPEIQRALRAPRKKIHRRVLK
P37275 S704 Sugiyama ZEB1 AREB6 TCF8 tNsPVLPVGsttNGsRsstPsPsPLNLSSSRNTQGYLYTAE
P37275 T702 Sugiyama ZEB1 AREB6 TCF8 KMtNsPVLPVGsttNGsRsstPsPsPLNLSSSRNTQGYLYT
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37837 S13 Sugiyama TALDO1 TAL TALDO TALDOR ________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P37840 S87 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP SNCA NACP PARK1 GGAVVTGVTAVAQKTVEGAGsIAAATGFVKKDQLGKNEEGA
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646 T87 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKR
P41091 T109 Sugiyama EIF2S3 EIF2G YKLDDPSCPRPECyRSCGsstPDEFPtDIPGtKGNFKLVRH
P42166 S79 Sugiyama TMPO LAP2 sKGPPDFssDEEREPtPVLGsGAAAAGRSRAAVGRKATKKT
P42166 T160 Sugiyama TMPO LAP2 KLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsNDs
P42166 T74 Sugiyama TMPO LAP2 PAGTNsKGPPDFssDEEREPtPVLGsGAAAAGRSRAAVGRK
P42167 S79 Sugiyama TMPO LAP2 SKGPPDFssDEEREPtPVLGsGAAAAGRSRAAVGRKATKKT
P42167 T160 Sugiyama TMPO LAP2 KLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSNDS
P42167 T74 Sugiyama TMPO LAP2 PAGTNSKGPPDFssDEEREPtPVLGsGAAAAGRSRAAVGRK
P42677 S11 Sugiyama RPS27 MPS1 __________MPLAKDLLHPsPEEEKRKHKKKRLVQsPNsy
P46013 S1131 Sugiyama MKI67 tPGPsEEsMtDEKTTKIACKsPPPEsVDtPtstKQWPKRSL
P46013 S1983 Sugiyama MKI67 tPGHtEEsMtDDKITEVsCKsPQPDPVKtPtsSKQRLKISL
P46013 S2105 Sugiyama MKI67 tPDHTEESttDDKTTKIACKsPPPEsMDtPTstRRRPKtPL
P48741 T40 Sugiyama HSPA7 HSP70B VGVFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQ
P49023 S303 Sugiyama PXN QRADGERCWAAGWPRDGGRssPGGQDEGGFMAQGKtGsssP
P49418 S262 SIGNOR AMPH AMPH1 AFTIQGAPSDSGPLRIAKtPsPPEEPsPLPsPtAsPNHTLA
P49418 S272 SIGNOR AMPH AMPH1 SGPLRIAKtPsPPEEPsPLPsPtAsPNHTLAPAsPAPARPR
P49418 S276 SIGNOR AMPH AMPH1 RIAKtPsPPEEPsPLPsPtAsPNHTLAPAsPAPARPRsPsQ
P49418 S285 SIGNOR AMPH AMPH1 EEPsPLPsPtAsPNHTLAPAsPAPARPRsPsQTRKGPPVPP
P49418 S293 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP AMPH AMPH1 PtAsPNHTLAPAsPAPARPRsPsQTRKGPPVPPLPKVtPtK
P49418 S295 GPS6|SIGNOR|EPSD|PSP AMPH AMPH1 AsPNHTLAPAsPAPARPRsPsQTRKGPPVPPLPKVtPtKEL
P49418 T310 GPS6|SIGNOR|EPSD|PSP AMPH AMPH1 RPRsPsQTRKGPPVPPLPKVtPtKELQQENIISFFEDNFVP
P49418 T312 EPSD|PSP AMPH AMPH1 RsPsQTRKGPPVPPLPKVtPtKELQQENIISFFEDNFVPEI
P51812 S715 Sugiyama RPS6KA3 ISPK1 MAPKAPK1B RSK2 APHLVKGAMAAtysALNRNQsPVLEPVGRsTLAQRRGIKKI
P51991 S358 Sugiyama HNRNPA3 HNRPA3 QQQSNYGPMKGGsFGGRssGsPyGGGyGsGGGsGGyGsRRF
P53805 S167 SIGNOR|EPSD|PSP RCAN1 ADAPT78 CSP1 DSC1 DSCR1 GSSHLAPPNPDKQFLIsPPAsPPVGWKQVEDAtPVINYDLL
P53805 T247 EPSD|PSP RCAN1 ADAPT78 CSP1 DSC1 DSCR1 EMERMRRPKPKIIQTRRPEYtPIHLS_______________
P54259 S101 Sugiyama ATN1 D12S755E DRPLA sEETNAPKKTKtEQELPRPQsPsDLDsLDGRsLNDDGSsDP
P54652 T39 Sugiyama HSPA2 VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P55211 T125 GPS6 CASP9 MCH6 NLtPVVLRPEIRKPEVLRPEtPRPVDIGSGGFGDVGALEsL
P55795 S104 Sugiyama HNRNPH2 FTP3 HNRPH2 EVFKSNsVEMDWVLKHtGPNsPDtANDGFVRLRGLPFGCSK
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60174 T214 Sugiyama TPI1 TPI KsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGG
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P61916 S40 Sugiyama NPC2 HE1 EPVQFKDCGsVDGVIKEVNVsPCPtQPCQLSKGQSYSVNVT
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981 S46 Sugiyama YWHAG AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S46 Sugiyama YWHAE SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62263 S70 Sugiyama RPS14 PRO2640 KETICRVTGGMKVKADRDEssPyAAMLAAQDVAQRCKELGI
P62263 T107 Sugiyama RPS14 PRO2640 ELGITALHIKLRATGGNRtKtPGPGAQsALRALARSGMKIG
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62750 S43 Sugiyama RPL23A KAKKAVLKGVHSHKKKKIRtsPTFRRPKTLRLRRQPKYPRK
P62750 T42 Sugiyama RPL23A LKAKKAVLKGVHSHKKKKIRtsPTFRRPKTLRLRRQPKYPR
P62942 S9 Sugiyama FKBP1A FKBP1 FKBP12 ____________MGVQVEtIsPGDGRtFPKRGQtCVVHytG
P62942 T7 Sugiyama FKBP1A FKBP1 FKBP12 ______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P62979 S123 Sugiyama RPS27A UBA80 UBCEP1 LKYYKVDENGKIsRLRRECPsDECGAGVFMAsHFDRHyCGK
P63104 S45 Sugiyama YWHAZ CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P83731 S38 Sugiyama RPL24 GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P84098 S37 Sugiyama RPL19 CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
Q00059 S160 Sugiyama TFAM TCF6 TCF6L2 RKAMTKKKELTLLGKPKRPRsAYNVyVAERFQEAKGDsPQE
Q00613 S363 Sugiyama HSF1 HSTF1 AsVTALtDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNE
Q01082 S2197 Sugiyama SPTBN1 SPTB2 KTALPAQsAAtLPARtQEtPsAQMEGFLNRKHEWEAHNKKA
Q01082 T2192 Sugiyama SPTBN1 SPTB2 sDRKAKTALPAQsAAtLPARtQEtPsAQMEGFLNRKHEWEA
Q02790 S15 Sugiyama FKBP4 FKBP52 ______MTAEEMKAtEsGAQsAPLPMEGVDIsPKQDEGVLK
Q04637 T207 Sugiyama EIF4G1 EIF4F EIF4G EIF4GI QGGKDITEEIMsGARtAstPtPPQtGGGLEPQANGEtPQVA
Q04917 S46 Sugiyama YWHAH YWHA1 AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q05193 S795 SIGNOR DNM1 DNM PTSsPtPQRRAPAVPPARPGsRGPAPGPPPAGSALGGAPPV
Q05193 S857 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP DNM1 DNM NRAPPGVPSRSGQAsPSRPEsPRPPFDL_____________
Q07955 S238 SIGNOR SRSF1 ASF SF2 SF2P33 SFRS1 OK/SW-cl.3 RsNsRsRsYsPRRsRGsPRYsPRHSRSRSRT__________
Q07960 S51 Sugiyama ARHGAP1 CDC42GAP RHOGAP1 KNWPsDEMPDFPKsDDsKsssPELVtHLKWDDPyyDIARHQ
Q08AD1 S1321 Sugiyama CAMSAP2 CAMSAP1L1 KIAA1078 sVHsGKRtPRsEsVEGFLsPsRCGsRNGEKDWENAsttssV
Q08AD1 S673 Sugiyama CAMSAP2 CAMSAP1L1 KIAA1078 DASKFLQDyDIRTGNTREALsPCPsTVsTKSQPGSSAssss
Q08J23 S743 Sugiyama NSUN2 SAKI TRM4 AstGQPDNDVtEGQRAGEPNsPDAEEANsPDVtAGCDPAGV
Q08J23 S751 Sugiyama NSUN2 SAKI TRM4 DVtEGQRAGEPNsPDAEEANsPDVtAGCDPAGVHPPR____
Q09666 S93 Sugiyama AHNAK PM227 LLNTMGHHTVGLKLHRKGDRsPEPGQtWtREVFssCssEVV
Q12778 S322 EPSD FOXO1 FKHR FOXO1A HsNDDFDNWSTFRPRtssNAstIsGRLsPIMtEQDDLGEGD
Q12778 S329 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP FOXO1 FKHR FOXO1A NWSTFRPRtssNAstIsGRLsPIMtEQDDLGEGDVHSMVYP
Q12913 S303 Sugiyama PTPRJ DEP1 DPLGTEGGLDASNTERSRAGsPTAPVHDESLVGPVDPSSGQ
Q13114 S75 PSP TRAF3 CAP-1 CRAF1 TRAFAMN KCHLVLCSPKQTECGHRFCEsCMAALLSSSSPKCTACQESI
Q13114 S9 PSP TRAF3 CAP-1 CRAF1 TRAFAMN ____________MESSKKMDsPGALQTNPPLKLHTDRSAGt
Q13114 T29 PSP TRAF3 CAP-1 CRAF1 TRAFAMN sPGALQTNPPLKLHTDRSAGtPVFVPEQGGYKEKFVKTVED
Q13158 S194 Sugiyama FADD MORT1 GIG3 ADLVQEVQQARDLQNRsGAMsPMsWNsDAsTSEAS______
Q13247 S301 Sugiyama SRSF6 SFRS6 SRP55 PKENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKR
Q13247 S303 Sugiyama SRSF6 SFRS6 SRP55 ENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKRAT
Q13263 Y133 Sugiyama TRIM28 KAP1 RNF96 TIF1B TVVDCPVCKQQCFSKDIVENyFMRDsGsKAATDAQDANQCC
Q13283 S232 Sugiyama G3BP1 G3BP EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13586 S620 Sugiyama STIM1 GOK sPsAPPGGsPHLDssRsHsPssPDPDtPsPVGDSRALQASR
Q13627 S258 GPS6 DYRK1A DYRK MNB MNBH FEMLSYNLYDLLRNTNFRGVsLNLTRKFAQQMCTALLFLAT
Q13627 S519 iPTMNet|EPSD DYRK1A DYRK MNB MNBH MEQsQssGttSSTSSSSGGSsGTSNSGRARsDPTHQHRHsG
Q13627 S529 GPS6|SIGNOR|EPSD|PSP DYRK1A DYRK MNB MNBH SSTSSSSGGSsGTSNSGRARsDPTHQHRHsGGHFtAAVQAM
Q13627 S748 Sugiyama DYRK1A DYRK MNB MNBH PAHYMTEGHLTMRQGADREEsPMtGVCVQQsPVAss_____
Q13627 S758 Sugiyama DYRK1A DYRK MNB MNBH TMRQGADREEsPMtGVCVQQsPVAss_______________
Q13627 S97 Sugiyama DYRK1A DYRK MNB MNBH LQRRMPQtFRDPAtAPLRKLsVDLIKTYKHINEVyYAKKKR
Q13627 T751 Sugiyama DYRK1A DYRK MNB MNBH YMTEGHLTMRQGADREEsPMtGVCVQQsPVAss________
Q13627 T84 Sugiyama DYRK1A DYRK MNB MNBH QPLTNQVMPDIVMLQRRMPQtFRDPAtAPLRKLsVDLIKTY
Q13627 T90 Sugiyama DYRK1A DYRK MNB MNBH VMPDIVMLQRRMPQtFRDPAtAPLRKLsVDLIKTYKHINEV
Q13627 Y111 Sugiyama DYRK1A DYRK MNB MNBH APLRKLsVDLIKTYKHINEVyYAKKKRRHQQGQGDDSSHKK
Q13627 Y136 Sugiyama DYRK1A DYRK MNB MNBH KRRHQQGQGDDSSHKKERKVyNDGyDDDNyDyIVKNGEKWM
Q13627 Y140 Sugiyama DYRK1A DYRK MNB MNBH QQGQGDDSSHKKERKVyNDGyDDDNyDyIVKNGEKWMDRYE
Q13627 Y319 SIGNOR DYRK1A DYRK MNB MNBH KRSAIKIVDFGSSCQLGQRIyQyIQSRFYRSPEVLLGMPYD
Q13627 Y321 SIGNOR|EPSD|Sugiyama DYRK1A DYRK MNB MNBH SAIKIVDFGSSCQLGQRIyQyIQSRFYRSPEVLLGMPYDLA
Q14004 S317 Sugiyama CDK13 CDC2L CDC2L5 CHED KIAA1791 PKAYREDKTEPKAYRRRRsLsPLGGRDDsPVsHRASQSLRs
Q14004 S325 Sugiyama CDK13 CDC2L CDC2L5 CHED KIAA1791 TEPKAYRRRRsLsPLGGRDDsPVsHRASQSLRsRKsPsPAG
Q14157 S477 Sugiyama UBAP2L KIAA0144 NICE4 PsKstsAPQMsPGssDNQsssPQPAQQKLKQQKKKAsLTSK
Q14160 S504 Sugiyama SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL MKRSIEGRRsEACPCQPDsGsPLPAEEEKRLsAESGLSEDS
Q14247 S405 Sugiyama CTTN EMS1 EEARRKLEEQARAKtQtPPVsPAPQPtEERLPssPVyEDAA
Q14247 T399 Sugiyama CTTN EMS1 KERQEQEEARRKLEEQARAKtQtPPVsPAPQPtEERLPssP
Q14247 T401 Sugiyama CTTN EMS1 RQEQEEARRKLEEQARAKtQtPPVsPAPQPtEERLPssPVy
Q14258 S100 Sugiyama TRIM25 EFP RNF147 ZNF147 DLAREPPADVWtPPARAsAPsPNAQVACDHCLKEAAVKTCL
Q14498 S334 Sugiyama RBM39 HCC1 RNPC2 FELAGRPMKVGHVTERtDAssAssFLDsDELERtGIDLGtT
Q14693 S438 Sugiyama LPIN1 KIAA0188 GDPSGLAKHASDNGARsANQsPQSVGSSGVDSGVESTSDGL
Q14814 S251 SIGNOR|PSP MEF2D sPGLLPVANGNsLNKVIPAKsPPPPtHstQLGAPSRKPDLR
Q15293 T76 Sugiyama RCN1 RCN FQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGD
Q15637 S82 Sugiyama SF1 ZFM1 ZNF162 TRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFRTR
Q15642 S298 Sugiyama TRIP10 CIP4 STOT STP RPGDVEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRSRT
Q16204 S244 Sugiyama CCDC6 D10S170 TST1 LEAEKRILQEKLDQPVsAPPsPRDIsMEIDsPENMMRHIRF
Q52LA3 S28 SIGNOR|EPSD|PSP LIN52 C14orf46 PTDGTDLEASLLSFEKLDRAsPDLWPEQLPGVAEFAAsFKs
Q53EL6 S94 Sugiyama PDCD4 H731 GDsVsDsGsDALRSGLtVPtsPKGRLLDRRSRSGKGRGLPK
Q5JSH3 S561 Sugiyama WDR44 RPH11 KNAFDYFNNMRMKYNtEGRVsPsPsQEsLsssKsDTDtGVC
Q5T0N5 S501 Sugiyama FNBP1L C1orf39 TOCA1 GRGDRRHssDINHLVtQGREsPEGsytDDANQEVRGPPQQH
Q5T5Y3 S563 Sugiyama CAMSAP1 VAIVRADVVPQQADPEFPRAsPRALGLtANARsPQGQLDts
Q6GYQ0 T1002 Sugiyama RALGAPA1 GARNL1 KIAA0884 TULIP1 TITGSESASPVHSPLGSRsQtPsPSTLNIDHMEQKDLQLDE
Q6NW29 S23 Sugiyama RWDD4 FAM28A RWDD4A ANEDQEMELEALRSIyEGDEsFRELsPVSFQyRIGENGDPK
Q6NW29 S28 Sugiyama RWDD4 FAM28A RWDD4A EMELEALRSIyEGDEsFRELsPVSFQyRIGENGDPKAFLIE
Q6QNY0 T16 Sugiyama BLOC1S3 BLOS3 _____MASQGRRRRPLRRPEtVVPGEAtEtDsERsAsssEE
Q6UN15 S492 Sugiyama FIP1L1 FIP1 RHE DRDRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAE
Q6UN15 S500 Sugiyama FIP1L1 FIP1 RHE ERTRERERERDHsPtPsVFNsDEERyRYREYAERGYERHRA
Q6UN15 T494 Sugiyama FIP1L1 FIP1 RHE DRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAERG
Q71RC2 S597 Sugiyama LARP4 PP13296 QttIPVsPPsttKPsRAstAsPCNNNINAAtAVALQEPRKL
Q7LBC6 S773 Sugiyama KDM3B C5orf7 JHDM2B JMJD1B KIAA1082 GPGQQDNPLLKTFsNVFGRHsGGFLssPADFsQENKAPFEA
Q7Z2W4 S378 Sugiyama ZC3HAV1 ZC3HDC2 PRO1677 NWKsLtsWtNDQGARRKtVFsPtLPAARssLGsLQtPEAVt
Q7Z2W4 T273 Sugiyama ZC3HAV1 ZC3HDC2 PRO1677 FFQGsQEFLASASAsAERsCtPsPDQIsHRAsLEDAPVDDL
Q7Z5K2 S221 Sugiyama WAPL FOE KIAA0261 WAPAL AsEIKETNDTWNSQFGKRPEsPsEIsPIKGsVRTGLFEWDN
Q7Z5K2 S223 Sugiyama WAPL FOE KIAA0261 WAPAL EIKETNDTWNSQFGKRPEsPsEIsPIKGsVRTGLFEWDNDF
Q86TB9 S179 Sugiyama PATL1 OK/KNS-cl.5 PQGPEDDRDLSERALPRRstsPIIGsPPVRAVPIGtPPKQM
Q86VM9 S607 Sugiyama ZC3H18 NHN1 SRHSSFSGSRSRsRsFsssPsPsPtPsPHRPsIRTKGEPAP
Q86VM9 S609 Sugiyama ZC3H18 NHN1 HSSFSGSRSRsRsFsssPsPsPtPsPHRPsIRTKGEPAPPP
Q86WR0 S187 Sugiyama CCDC25 KKREKEEMKKKREMDELRSYssLMKVENMSSNQDGNDsDEF
Q86YP4 S100 Sugiyama GATAD2A DGPVDMRTSHSDMKSERRPPsPDVIVLsDNEQPssPRVNGL
Q8IWW6 S240 Sugiyama ARHGAP12 SSSsTEQIRAttPPNQGRPDsPVyANLQELKISQSALPPLP
Q8IWW6 T230 Sugiyama ARHGAP12 HQDSEsGDELSSSsTEQIRAttPPNQGRPDsPVyANLQELK
Q8IWW6 T231 Sugiyama ARHGAP12 QDSEsGDELSSSsTEQIRAttPPNQGRPDsPVyANLQELKI
Q8IWX8 S815 Sugiyama CHERP DAN26 SCAF6 RSQSRSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIP
Q8IWX8 S817 Sugiyama CHERP DAN26 SCAF6 QSRSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDS
Q8IZ21 S118 Sugiyama PHACTR4 PRO2963 PSDAMLKNGHTTPIGNARsssPVQVEEEPVRLAsLRKAIPE
Q8N556 S265 Sugiyama AFAP1 AFAP KEAYSGCSGPVDSECPPPPssPVHKAELEKKLssERPssDG
Q8N684 T203 Sugiyama CPSF7 GGIPPRAHsRDssDsADGRAtPsENLVPSSARVDKPPSVLP
Q8N6T3 S343 Sugiyama ARFGAP1 ARF1GAP NIDQSFWETFGSAEPTKtRKsPssDsWtCADtstERRssDs
Q8NBJ5 S612 Sugiyama COLGALT1 GLT25D1 PSEC0241 QKMREQQALSREAKNsDVLQsPLDsAARDEL__________
Q8NBS9 S292 Sugiyama TXNDC5 TLP46 UNQ364/PRO700 KKVDQYKGKRDLEsLREyVEsQLQRTETGATETVTPSEAPV
Q8ND56 S183 Sugiyama LSM14A C19orf13 FAM61A RAP55 RAP55A GSAFTQDTRsLKtQLsQGRssPQLDPLRKsPtMEQAVQtAs
Q8TAD8 S35 Sugiyama SNIP1 RHRDGDVVLPAGVVVKQERLsPEVAPPAHRRPDHsGGsPsP
Q8TC07 S675 Sugiyama TBC1D15 TSAFQSNALPTLSASGARNDsPtQIPVssDVCRLtPA____
Q8TDD1 S624 Sugiyama DDX54 FQQGQQGRQEQQEGPVGPAPsRPALQEKQPEKEEEEEAGEs
Q8TEW0 S962 Sugiyama PARD3 PAR3 PAR3A DEGMEtLEEDTEESSRsGREsVstAsDQPsHsLERQMNGNQ
Q8WW12 T139 Sugiyama PCNP sEPEEMPPEAKMRMKNIGRDtPtsAGPNsFNKGKHGFsDNQ
Q8WWM7 S111 Sugiyama ATXN2L A2D A2LG A2LP A2RP PGAAAIGsARGQstGKGPPQsPVFEGVyNNSRMLHFLTAVV
Q8WY36 S844 Sugiyama BBX HBP2 KRKARKTKITHLVRtADGRVsPAGGTLDDKPKEQLQRSLPK
Q8WZ42 S20761 Sugiyama TTN GGSPIINYVVQKRDAERKSWsTVTTECsKTSFRVANLEEGK
Q8WZ42 S20768 Sugiyama TTN YVVQKRDAERKSWsTVTTECsKTSFRVANLEEGKSYFFRVF
Q92499 S481 Sugiyama DDX1 KSHIRTDDVHAKDNTRPGANsPEMWSEAIKILKGEYAVRAI
Q92609 S539 Sugiyama TBC1D5 KIAA0210 KsEsMPVQLNKGLSSKNIsssPsVEsLPGGREFtGsPPssA
Q96B36 S212 Sugiyama AKT1S1 PRAS40 GFKEKRtEARssDEENGPPssPDLDRIAAsMRALVLREAED
Q96CW6 S302 Sugiyama SLC7A6OS SRQRMWSKYPLDVQKEFGyDsPHDLDsD_____________
Q96D46 S462 Sugiyama NMD3 CGI-07 FLEDLEEDEAIRKNVNIyRDsAIPVEsDtDDEGAPRISLAE
Q96EB6 T530 GPS6|EPSD SIRT1 SIR2L1 ITEKPPRTQKELAYLSELPPtPLHVsEDsssPERtsPPDss
Q96EK9 S184 Sugiyama KTI12 SBBI81 GSAQADVPKELEREEsGAAEsPALVtPDSEKSAKHGsGAFy
Q96EN8 S530 Sugiyama MOCOS APSADSQADVIPAVMGRRsLsPQEDALTGSRVWNNSSTVNA
Q96GM8 S420 Sugiyama TOE1 KNDLEMGIKAARPEIADRATsEVPGsQAsPNPVPGDGLHRA
Q96MH2 S76 Sugiyama HEXIM2 L3 EDLAGAVGGLGWNsRsPRtQsPGGCsAEAVLARKKHRRRPS
Q96MH2 T74 Sugiyama HEXIM2 L3 EDEDLAGAVGGLGWNsRsPRtQsPGGCsAEAVLARKKHRRR
Q96MU7 S308 Sugiyama YTHDC1 KIAA1966 YT521 GSGTDGsDEKKKERKRARGIsPIVFDRsGssAsESYAGsEK
Q96QT6 T129 Sugiyama PHF12 KIAA1523 REQKKELGHVNGLVDKSGKRttsPssDtDLLDRsAsKTELK
Q96S44 T8 Sugiyama TP53RK C20orf64 PRPK _____________MAAARAttPADGEEPAPEAEALAAARER
Q96S94 S330 SIGNOR|EPSD|PSP CCNL2 SB138 AQARGLLPGGTQVLDGtsGFsPAPKLVEsPKEGKGsKPsPL
Q96S94 S338 SIGNOR|iPTMNet|EPSD|PSP CCNL2 SB138 GGTQVLDGtsGFsPAPKLVEsPKEGKGsKPsPLSVKNTKRR
Q96S94 S369 SIGNOR|iPTMNet|EPSD|PSP CCNL2 SB138 PLSVKNTKRRLEGAKKAKADsPVNGLPKGRESRSRSRSREQ
Q99569 S314 Sugiyama PKP4 RQTSNPNGPTPQyQtTARVGsPLTLTDAQTRVAsPSQGQVG
Q99640 S120 Sugiyama PKMYT1 MYT1 sRPEsFFQQsFQRLSRLGHGsyGEVFKVRSKEDGRLYAVKR
Q99640 Y121 Sugiyama PKMYT1 MYT1 RPEsFFQQsFQRLSRLGHGsyGEVFKVRSKEDGRLYAVKRs
Q9BTA9 S525 Sugiyama WAC KIAA1844 QGHEPVsPRSLQRsssQRsPsPGPNHtsNssNAsNATVVPQ
Q9BY44 T512 Sugiyama EIF2A CDA02 MSTP004 MSTP089 EAKKAAKQEARsDKsPDLAPtPAPQstPRNtVsQsIsGDPE
Q9BYG3 T234 Sugiyama NIFK MKI67IP NOPP34 KKKVsGtLDtPEKtVDsQGPtPVCtPtFLERRKsQVAELND
Q9BYG3 T238 Sugiyama NIFK MKI67IP NOPP34 sGtLDtPEKtVDsQGPtPVCtPtFLERRKsQVAELNDDDKD
Q9C0C2 S1103 Sugiyama TNKS1BP1 KIAA1741 TAB182 KRGWVGEFSLSVGPQREAAFsPGQQDWsRDFCIEASERsyQ
Q9C0C2 S1383 Sugiyama TNKS1BP1 KIAA1741 TAB182 REHGVGGVsQCPEPGLRHNGsLsPGLEARDPLEARELGVGE
Q9C0C2 S435 Sugiyama TNKS1BP1 KIAA1741 TAB182 DAHLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAALPQGQG
Q9C0C2 S601 Sugiyama TNKS1BP1 KIAA1741 TAB182 LPLQQAEERyEsQEPLAGQEsPLPLATREAALPILEPVLGQ
Q9C0C2 S672 Sugiyama TNKS1BP1 KIAA1741 TAB182 TLARAETtQARtEAQDLCRAsPEPPGPEsSSRWLDDLLAsP
Q9C0D5 S270 Sugiyama TANC1 KIAA1728 GNLRLGVQKGVLHDRRADNCsPVAEEETTGsAEStLPKAES
Q9H4A3 S1261 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 GIPTSSLTQVVHSAGRRFIVsPVPEsRLRESKVFPSEITDT
Q9H4G0 S784 Sugiyama EPB41L1 KIAA0338 KGAAAMIPGPQTVATEIRsLsPIIGKDVLtstyGAtAEtLS
Q9H773 S26 Sugiyama DCTPP1 XTP3TPA CDA03 GEIRGDTGGEDTAAPGRFsFsPEPTLEDIRRLHAEFAAERD
Q9H7N4 S498 Sugiyama SCAF1 SFRS19 SRA1 GGLDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKK
Q9H7N4 S500 Sugiyama SCAF1 SFRS19 SRA1 LDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKKSR
Q9H7N4 Y494 Sugiyama SCAF1 SFRS19 SRA1 DSRWGGLDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPP
Q9HC35 S146 Sugiyama EML4 C2orf2 EMAPL4 REKKEEsHsNDQsPQIRAsPsPQPssQPLQIHRQtPEsKNA
Q9HCN4 S301 Sugiyama GPN1 MBDIN RPAP4 XAB1 HUSSY-23 ANAESQQQREQLERLRKDMGsVALDAGtAKDsLsPVLHPsD
Q9HDC5 S413 Sugiyama JPH1 JP1 QAALAARQECDIARAVARELsPDFyQPGPDyVKQRFQEGVD
Q9NPI6 S525 Sugiyama DCP1A SMIF SVFQQTVTRSSDLERKAssPsPLtIGtPEsQRKPSIILSKs
Q9NR19 S30 Sugiyama ACSS2 ACAS2 sGsGSRGQEEAGAGGRARsWsPPPEVsRSAHVPSLQRYREL
Q9NR28 S230 Sugiyama DIABLO SMAC EAQIEELRQKTQEEGEERAEsEQEAyLRED___________
Q9NUQ3 S97 Sugiyama TXLNG CXorf15 ELRG LSR5 KHSLEEDEGsDFItENRNLVsPAyCtQEsREEIPGGEARTD
Q9NWB6 S77 Sugiyama ARGLU1 RsRstNTAVSRRERDRERAssPPDRIDIFGRTVSKRSSLDE
Q9NYV4 S423 Sugiyama CDK12 CRK7 CRKRS KIAA0904 KKERAAAAAAAKMDGKEsKGsPVFLPRKENSSVEAKDsGLE
Q9NYY3 S358 SIGNOR PLK2 SNK FTPDRLSSSCCHTVPDFHLSsPAKNFFKKAAAALFGGKKDK
Q9NZB2 T991 Sugiyama FAM120A C9orf10 KIAA0183 OSSA PLQVVSVGGPARGRPRGVIstPVIRTFGRGGRYYGRGYKNQ
Q9P2R6 S679 Sugiyama RERE ARG ARP ATN1L KIAA0458 EEADRTSSKKTKTQEIsRPNsPsEGEGESSDSRsVNDEGSS
Q9UGV2 S361 Sugiyama NDRG3 sPFsRsVtsNQsDGtQESCEsPDVLDRHQTMEVsC______
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UPQ0 S212 Sugiyama LIMCH1 KIAA1102 sPPRHGRDDsFDsLDsFGsRsRQtPsPDVVLRGssDGRGsD
Q9UPQ0 S217 Sugiyama LIMCH1 KIAA1102 GRDDsFDsLDsFGsRsRQtPsPDVVLRGssDGRGsDsEsDL
Q9UQ35 S1103 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35 S2132 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9UQ35 S323 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 RGEGDAPFsEPGttstQRPssPEtAtKQPssPYEDKDKDKK
Q9Y2K6 S372 Sugiyama USP20 KIAA1003 LSFR3A VDU2 tAMAALDDQPAEAQPPsPRsssPCRtPEPDNDAHLRSSsRP
Q9Y2K6 T377 Sugiyama USP20 KIAA1003 LSFR3A VDU2 LDDQPAEAQPPsPRsssPCRtPEPDNDAHLRSSsRPCsPVH
Q9Y2U5 S164 Sugiyama MAP3K2 MAPKKK2 MEKK2 FGAERKKRLsIIGPTSRDRssPPPGYIPDELHQVARNGSFT
Q9Y2V2 S30 Sugiyama CARHSP1 QPPtHQAsVGLLDtPRsRERsPsPLRGNVVPsPLPtRRtRt
Q9Y2V2 S32 Sugiyama CARHSP1 PtHQAsVGLLDtPRsRERsPsPLRGNVVPsPLPtRRtRtFs
Q9Y2V2 S41 Sugiyama CARHSP1 LDtPRsRERsPsPLRGNVVPsPLPtRRtRtFsAtVRASQGP
Q9Y3Z3 T365 Sugiyama SAMHD1 MOP5 NELRICARDKEVGNLYDMFHtRNSLHRRAYQHKVGNIIDTM
Q9Y463 S49 Sugiyama DYRK1B MIRK LPRRLPLAFRDATSAPLRKLsVDLIKTYKHINEVyYAKKKR
Q9Y463 Y273 Sugiyama DYRK1B MIRK SAIKIVDFGSSCQLGQRIyQyIQSRFYRSPEVLLGTPYDLA
Q9Y463 Y63 Sugiyama DYRK1B MIRK APLRKLsVDLIKTYKHINEVyYAKKKRRAQQAPPQDSSNKK
Q9Y6G9 S516 Sugiyama DYNC1LI1 DNCLI1 HAELDRITRKPVtVsPttPtsPtEGEAs_____________
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Chromatin organization R-HSA-4839726 1.794074e-08 7.746 0 0
Chromatin modifying enzymes R-HSA-3247509 8.114492e-08 7.091 0 0
Cell Cycle R-HSA-1640170 1.055530e-06 5.977 1 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 1.475191e-05 4.831 0 0
Cell Cycle, Mitotic R-HSA-69278 2.575259e-05 4.589 1 0
Regulation of TP53 Activity R-HSA-5633007 2.879583e-05 4.541 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 3.189868e-05 4.496 0 0
PKMTs methylate histone lysines R-HSA-3214841 5.811373e-05 4.236 0 0
Circadian clock R-HSA-9909396 6.713850e-05 4.173 0 0
Gene expression (Transcription) R-HSA-74160 9.305512e-05 4.031 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.011368e-04 3.995 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.461566e-04 3.835 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.601640e-04 3.795 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.138615e-04 3.670 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.036080e-04 3.518 0 0
RNA Polymerase II Transcription R-HSA-73857 3.000782e-04 3.523 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 3.252921e-04 3.488 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 4.035598e-04 3.394 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 4.695351e-04 3.328 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 5.620136e-04 3.250 0 0
Generic Transcription Pathway R-HSA-212436 5.745922e-04 3.241 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 5.330542e-04 3.273 0 0
Regulation of PTEN gene transcription R-HSA-8943724 6.705383e-04 3.174 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 7.024405e-04 3.153 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 7.314408e-04 3.136 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 7.727976e-04 3.112 0 0
NRAGE signals death through JNK R-HSA-193648 7.710823e-04 3.113 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 8.109978e-04 3.091 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 8.657126e-04 3.063 0 0
Cell Cycle Checkpoints R-HSA-69620 9.435880e-04 3.025 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 9.805827e-04 3.009 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.052646e-03 2.978 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.150286e-03 2.939 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.225505e-03 2.912 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.295196e-03 2.888 0 0
Cardiogenesis R-HSA-9733709 1.295196e-03 2.888 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.439917e-03 2.842 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 1.594752e-03 2.797 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 1.594752e-03 2.797 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.594752e-03 2.797 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.572952e-03 2.803 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.631391e-03 2.787 0 0
Deubiquitination R-HSA-5688426 1.896208e-03 2.722 0 0
M Phase R-HSA-68886 2.035255e-03 2.691 0 0
Notch-HLH transcription pathway R-HSA-350054 2.078131e-03 2.682 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.224001e-03 2.653 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.157225e-03 2.666 0 0
Regulation of TP53 Expression R-HSA-6804754 2.444448e-03 2.612 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.482942e-03 2.605 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.543110e-03 2.595 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.739426e-03 2.562 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.915320e-03 2.535 0 0
Estrogen-dependent gene expression R-HSA-9018519 3.052025e-03 2.515 0 0
Signal Transduction R-HSA-162582 3.106019e-03 2.508 0 0
Cellular Senescence R-HSA-2559583 3.130571e-03 2.504 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 3.455764e-03 2.461 0 0
HATs acetylate histones R-HSA-3214847 3.485447e-03 2.458 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.522906e-03 2.453 0 0
HDMs demethylate histones R-HSA-3214842 4.426138e-03 2.354 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 4.475137e-03 2.349 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 4.576670e-03 2.339 0 0
Heme signaling R-HSA-9707616 4.712443e-03 2.327 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 5.360991e-03 2.271 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 5.360991e-03 2.271 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 5.378862e-03 2.269 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.929552e-03 2.307 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 4.929552e-03 2.307 0 0
Adipogenesis R-HSA-9843745 5.146378e-03 2.288 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.929552e-03 2.307 0 0
NGF-stimulated transcription R-HSA-9031628 5.672788e-03 2.246 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 6.064768e-03 2.217 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 6.064768e-03 2.217 0 0
Signaling by NTRKs R-HSA-166520 6.072852e-03 2.217 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 6.885381e-03 2.162 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 7.356718e-03 2.133 0 0
Repression of WNT target genes R-HSA-4641265 7.356718e-03 2.133 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 7.356718e-03 2.133 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 7.397509e-03 2.131 0 0
RUNX2 regulates bone development R-HSA-8941326 7.687393e-03 2.114 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 7.824190e-03 2.107 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 8.561551e-03 2.067 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 8.561551e-03 2.067 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 8.561551e-03 2.067 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 8.677393e-03 2.062 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 8.949951e-03 2.048 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 8.949951e-03 2.048 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 9.175885e-03 2.037 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 9.501875e-03 2.022 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 9.991620e-03 2.000 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 9.938174e-03 2.003 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 9.536684e-03 2.021 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.013003e-02 1.994 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.038439e-02 1.984 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.063254e-02 1.973 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.145462e-02 1.941 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.093059e-02 1.961 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.142826e-02 1.942 0 0
Gastrulation R-HSA-9758941 1.087828e-02 1.963 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.074493e-02 1.969 0 0
PTEN Regulation R-HSA-6807070 1.158727e-02 1.936 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.179865e-02 1.928 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.198995e-02 1.921 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.198995e-02 1.921 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.280577e-02 1.893 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.280577e-02 1.893 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.282247e-02 1.892 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.282247e-02 1.892 0 0
Nuclear import of Rev protein R-HSA-180746 1.280577e-02 1.893 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.316159e-02 1.881 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.316159e-02 1.881 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.316159e-02 1.881 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.316159e-02 1.881 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.515599e-02 1.819 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 1.531071e-02 1.815 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.502026e-02 1.823 0 0
Signaling by NOTCH1 R-HSA-1980143 1.442136e-02 1.841 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.595410e-02 1.797 0 0
S Phase R-HSA-69242 1.610926e-02 1.793 0 0
Signaling by TGFB family members R-HSA-9006936 1.614085e-02 1.792 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 1.664700e-02 1.779 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.734872e-02 1.761 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.694930e-02 1.771 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.749442e-02 1.757 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.739439e-02 1.760 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.791655e-02 1.747 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.835834e-02 1.736 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 1.871961e-02 1.728 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.871961e-02 1.728 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.899342e-02 1.721 0 0
Germ layer formation at gastrulation R-HSA-9754189 1.949875e-02 1.710 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.949875e-02 1.710 0 0
mRNA Splicing R-HSA-72172 2.033171e-02 1.692 0 0
Mitotic Prometaphase R-HSA-68877 2.075555e-02 1.683 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.081866e-02 1.682 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.030925e-02 1.692 0 0
Apoptotic execution phase R-HSA-75153 1.956302e-02 1.709 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.114851e-02 1.675 0 0
Mitotic Prophase R-HSA-68875 2.154130e-02 1.667 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.215823e-02 1.654 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.464751e-02 1.608 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.407169e-02 1.618 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.407169e-02 1.618 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.407169e-02 1.618 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.407169e-02 1.618 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.407169e-02 1.618 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.462137e-02 1.609 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.511505e-02 1.600 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.338883e-02 1.631 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 2.417730e-02 1.617 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.417730e-02 1.617 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.531880e-02 1.597 0 0
G2/M Checkpoints R-HSA-69481 2.541152e-02 1.595 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.542684e-02 1.595 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 2.555462e-02 1.593 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.555462e-02 1.593 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.980672e-02 1.526 0 0
RAF activation R-HSA-5673000 2.888672e-02 1.539 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.026538e-02 1.519 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 3.026538e-02 1.519 0 0
TGFBR3 expression R-HSA-9839394 2.980672e-02 1.526 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.895373e-02 1.538 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.895373e-02 1.538 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.895373e-02 1.538 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.895373e-02 1.538 0 0
G2/M Transition R-HSA-69275 2.923973e-02 1.534 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.895373e-02 1.538 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.135151e-02 1.504 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 3.142823e-02 1.503 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 3.142823e-02 1.503 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.171200e-02 1.499 0 0
Frs2-mediated activation R-HSA-170968 3.171200e-02 1.499 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 3.205972e-02 1.494 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 3.205972e-02 1.494 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.205972e-02 1.494 0 0
Nuclear Receptor transcription pathway R-HSA-383280 3.223941e-02 1.492 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.236680e-02 1.490 0 0
MET interacts with TNS proteins R-HSA-8875513 3.246089e-02 1.489 0 0
mRNA Splicing - Major Pathway R-HSA-72163 3.261710e-02 1.487 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.309118e-02 1.480 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.343581e-02 1.476 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 3.520759e-02 1.453 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.664416e-02 1.436 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.724150e-02 1.429 0 0
Specification of primordial germ cells R-HSA-9827857 3.438686e-02 1.464 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.520759e-02 1.453 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.727752e-02 1.429 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 3.425308e-02 1.465 0 0
G1/S-Specific Transcription R-HSA-69205 3.846913e-02 1.415 0 0
Diseases of DNA repair R-HSA-9675135 3.923166e-02 1.406 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 3.998444e-02 1.398 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 4.006333e-02 1.397 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 4.006333e-02 1.397 0 0
Mitotic Anaphase R-HSA-68882 4.131306e-02 1.384 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.163081e-02 1.381 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 4.190933e-02 1.378 0 0
Polo-like kinase mediated events R-HSA-156711 4.190933e-02 1.378 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 4.217379e-02 1.375 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 4.361516e-02 1.360 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.400746e-02 1.356 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 5.060821e-02 1.296 0 0
Formation of the posterior neural plate R-HSA-9832991 4.576328e-02 1.339 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 4.777520e-02 1.321 0 0
Specification of the neural plate border R-HSA-9834899 5.042344e-02 1.297 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 5.006930e-02 1.300 0 0
Intracellular signaling by second messengers R-HSA-9006925 4.865440e-02 1.313 0 0
Homology Directed Repair R-HSA-5693538 4.671260e-02 1.331 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 4.990625e-02 1.302 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 5.056926e-02 1.296 1 0
Cell-extracellular matrix interactions R-HSA-446353 4.949260e-02 1.305 0 0
Formation of the anterior neural plate R-HSA-9823739 4.949260e-02 1.305 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 4.627129e-02 1.335 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.709500e-02 1.327 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 4.952882e-02 1.305 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 4.627129e-02 1.335 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 4.677747e-02 1.330 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 5.082062e-02 1.294 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 5.082062e-02 1.294 0 0
Resolution of D-Loop Structures R-HSA-5693537 5.301814e-02 1.276 0 0
G1/S Transition R-HSA-69206 5.323511e-02 1.274 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 5.471566e-02 1.262 0 0
G alpha (12/13) signalling events R-HSA-416482 5.522578e-02 1.258 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 5.551953e-02 1.256 0 0
Cellular response to heat stress R-HSA-3371556 5.762715e-02 1.239 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.801074e-02 1.236 0 0
Activation of RAC1 R-HSA-428540 5.801074e-02 1.236 0 0
Signaling by AXIN mutants R-HSA-4839735 5.801074e-02 1.236 0 0
Transport of glycerol from adipocytes to the liver by Aquaporins R-HSA-432030 6.470801e-02 1.189 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 6.470801e-02 1.189 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 6.679577e-02 1.175 0 0
Type I hemidesmosome assembly R-HSA-446107 6.679577e-02 1.175 0 0
MET receptor recycling R-HSA-8875656 6.679577e-02 1.175 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 6.679577e-02 1.175 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 6.679577e-02 1.175 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 6.028615e-02 1.220 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 5.995577e-02 1.222 0 0
Amplification of signal from the kinetochores R-HSA-141424 6.539629e-02 1.184 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 6.539629e-02 1.184 0 0
Formation of definitive endoderm R-HSA-9823730 5.995577e-02 1.222 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.028615e-02 1.220 0 0
Killing mechanisms R-HSA-9664420 6.028615e-02 1.220 0 0
Protein-protein interactions at synapses R-HSA-6794362 6.031797e-02 1.220 0 0
Prolonged ERK activation events R-HSA-169893 6.028615e-02 1.220 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 6.917130e-02 1.160 0 0
Signalling to ERKs R-HSA-187687 6.838724e-02 1.165 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 6.637766e-02 1.178 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 6.038577e-02 1.219 0 0
Interleukin-37 signaling R-HSA-9008059 6.407555e-02 1.193 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 6.308114e-02 1.200 0 0
Separation of Sister Chromatids R-HSA-2467813 6.969487e-02 1.157 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.052187e-02 1.152 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.100354e-02 1.149 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 7.195310e-02 1.143 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 7.195310e-02 1.143 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 7.234388e-02 1.141 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 7.317489e-02 1.136 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 7.317489e-02 1.136 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 7.317489e-02 1.136 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 7.380523e-02 1.132 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 7.380523e-02 1.132 0 0
Signaling downstream of RAS mutants R-HSA-9649948 7.380523e-02 1.132 0 0
Signaling by RAS mutants R-HSA-6802949 7.380523e-02 1.132 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 7.380523e-02 1.132 0 0
mRNA 3'-end processing R-HSA-72187 7.537154e-02 1.123 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.608031e-02 1.119 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 7.638898e-02 1.117 0 0
UCH proteinases R-HSA-5689603 7.715207e-02 1.113 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 7.720176e-02 1.112 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 7.720176e-02 1.112 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 8.533665e-02 1.069 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 8.756260e-02 1.058 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 8.756260e-02 1.058 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 8.877956e-02 1.052 0 0
G0 and Early G1 R-HSA-1538133 8.280711e-02 1.082 1 1
Diseases of mitotic cell cycle R-HSA-9675126 8.280711e-02 1.082 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 8.632439e-02 1.064 0 0
MET promotes cell motility R-HSA-8875878 9.626638e-02 1.017 0 0
Metabolism of non-coding RNA R-HSA-194441 8.367728e-02 1.077 0 0
snRNP Assembly R-HSA-191859 8.367728e-02 1.077 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 9.139372e-02 1.039 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 8.395786e-02 1.076 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.358884e-02 1.078 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 8.280711e-02 1.082 0 0
Signaling by WNT in cancer R-HSA-4791275 8.280711e-02 1.082 0 0
FOXO-mediated transcription R-HSA-9614085 8.634854e-02 1.064 0 0
Formation of axial mesoderm R-HSA-9796292 8.756260e-02 1.058 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 9.328631e-02 1.030 0 0
Activation of ATR in response to replication stress R-HSA-176187 9.328631e-02 1.030 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 9.328631e-02 1.030 0 0
Ub-specific processing proteases R-HSA-5689880 8.449846e-02 1.073 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 9.139372e-02 1.039 0 0
Signaling by Hippo R-HSA-2028269 8.573931e-02 1.067 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 9.476230e-02 1.023 0 0
Death Receptor Signaling R-HSA-73887 8.111792e-02 1.091 0 0
Signaling by NOTCH R-HSA-157118 9.642601e-02 1.016 0 0
DNA Repair R-HSA-73894 9.747133e-02 1.011 0 0
Sensory processing of sound R-HSA-9659379 9.748148e-02 1.011 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.813454e-02 1.008 0 0
TBC/RABGAPs R-HSA-8854214 9.813454e-02 1.008 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 9.841006e-02 1.007 0 0
DNA Double Strand Break Response R-HSA-5693606 9.911725e-02 1.004 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 9.911725e-02 1.004 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 9.912254e-02 1.004 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 9.912254e-02 1.004 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 9.912254e-02 1.004 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 9.912254e-02 1.004 0 0
Rab regulation of trafficking R-HSA-9007101 9.928453e-02 1.003 0 0
Viral Messenger RNA Synthesis R-HSA-168325 9.954009e-02 1.002 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.003705e-01 0.998 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 1.003705e-01 0.998 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 1.006834e-01 0.997 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.045041e-01 0.981 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.047834e-01 0.980 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.047834e-01 0.980 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.052640e-01 0.978 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.053587e-01 0.977 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.053821e-01 0.977 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.053821e-01 0.977 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.053821e-01 0.977 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.053821e-01 0.977 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.053821e-01 0.977 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.053821e-01 0.977 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.053821e-01 0.977 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.053821e-01 0.977 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.053821e-01 0.977 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.053821e-01 0.977 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.053821e-01 0.977 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.134356e-01 0.945 0 0
Centrosome maturation R-HSA-380287 1.143829e-01 0.942 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.282441e-01 0.892 0 0
Deletions in the AXIN1 gene destabilize the destruction complex R-HSA-5467345 1.282441e-01 0.892 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.282441e-01 0.892 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.282441e-01 0.892 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.282441e-01 0.892 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.281811e-01 0.892 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 1.281811e-01 0.892 0 0
Signaling by APC mutants R-HSA-4839744 1.288948e-01 0.890 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.288948e-01 0.890 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.288948e-01 0.890 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.288948e-01 0.890 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 1.437163e-01 0.842 0 0
Differentiation of T cells R-HSA-9945266 1.437163e-01 0.842 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.230513e-01 0.910 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.270164e-01 0.896 0 0
MAP2K and MAPK activation R-HSA-5674135 1.424088e-01 0.846 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.424088e-01 0.846 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.298783e-01 0.886 0 0
Neurexins and neuroligins R-HSA-6794361 1.291853e-01 0.889 0 0
Hedgehog 'on' state R-HSA-5632684 1.341754e-01 0.872 0 0
RET signaling R-HSA-8853659 1.424687e-01 0.846 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.187331e-01 0.925 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.249689e-01 0.903 0 0
Activation of SMO R-HSA-5635838 1.437163e-01 0.842 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.195233e-01 0.923 0 0
Activation of BH3-only proteins R-HSA-114452 1.270164e-01 0.896 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 1.281811e-01 0.892 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.265860e-01 0.898 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 1.437163e-01 0.842 0 0
DCC mediated attractive signaling R-HSA-418885 1.235351e-01 0.908 0 0
Signaling by TGFBR3 R-HSA-9839373 1.298783e-01 0.886 0 0
FLT3 Signaling R-HSA-9607240 1.299388e-01 0.886 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 1.437163e-01 0.842 0 0
Signaling by WNT R-HSA-195721 1.475450e-01 0.831 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 1.510082e-01 0.821 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.510082e-01 0.821 0 0
MET activates PTPN11 R-HSA-8865999 1.510082e-01 0.821 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.513839e-01 0.820 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.535254e-01 0.814 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.535254e-01 0.814 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.535254e-01 0.814 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.542380e-01 0.812 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.551354e-01 0.809 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.551354e-01 0.809 0 0
MTOR signalling R-HSA-165159 1.554741e-01 0.808 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 1.598295e-01 0.796 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.598295e-01 0.796 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.598295e-01 0.796 0 0
Regulation of PTEN localization R-HSA-8948747 1.598295e-01 0.796 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 1.598295e-01 0.796 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 1.598295e-01 0.796 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 1.598295e-01 0.796 0 0
Signaling by MET R-HSA-6806834 1.606392e-01 0.794 0 0
HDACs deacetylate histones R-HSA-3214815 1.636648e-01 0.786 0 0
Signaling by NOTCH3 R-HSA-9012852 1.636648e-01 0.786 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.645061e-01 0.784 0 0
Apoptosis R-HSA-109581 1.650783e-01 0.782 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.652082e-01 0.782 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 1.652082e-01 0.782 0 0
Disorders of Developmental Biology R-HSA-9675151 1.652082e-01 0.782 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.652082e-01 0.782 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.400480e-01 0.620 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.400480e-01 0.620 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.400480e-01 0.620 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.400480e-01 0.620 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.400480e-01 0.620 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.400480e-01 0.620 0 0
Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) R-HSA-9036092 2.400480e-01 0.620 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.400480e-01 0.620 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.400480e-01 0.620 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.996486e-01 0.700 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.996486e-01 0.700 0 0
Signaling by MAP2K mutants R-HSA-9652169 1.996486e-01 0.700 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 1.996486e-01 0.700 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 3.375187e-01 0.472 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.375187e-01 0.472 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.375187e-01 0.472 0 0
XAV939 stabilizes AXIN R-HSA-5545619 3.375187e-01 0.472 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 3.375187e-01 0.472 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.375187e-01 0.472 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 3.375187e-01 0.472 0 0
Defective VWF binding to collagen type I R-HSA-9845622 3.375187e-01 0.472 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.375187e-01 0.472 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.375187e-01 0.472 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 3.375187e-01 0.472 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 3.375187e-01 0.472 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 3.375187e-01 0.472 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.497806e-01 0.602 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.497806e-01 0.602 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.497806e-01 0.602 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 2.497806e-01 0.602 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 1.935388e-01 0.713 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 1.935388e-01 0.713 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.797564e-01 0.745 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.797564e-01 0.745 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.797564e-01 0.745 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.797564e-01 0.745 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.797564e-01 0.745 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.797564e-01 0.745 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.287947e-01 0.641 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.287947e-01 0.641 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 2.287947e-01 0.641 0 0
WNT mediated activation of DVL R-HSA-201688 2.287947e-01 0.641 0 0
ALK mutants bind TKIs R-HSA-9700645 2.287947e-01 0.641 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.002224e-01 0.523 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 3.002224e-01 0.523 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 3.002224e-01 0.523 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 3.002224e-01 0.523 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.002224e-01 0.523 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.224927e-01 0.374 0 0
Glycogen storage disease type IV (GBE1) R-HSA-3878781 4.224927e-01 0.374 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 4.224927e-01 0.374 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 4.224927e-01 0.374 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 4.224927e-01 0.374 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.073446e-01 0.683 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 1.878789e-01 0.726 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.705456e-01 0.768 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 2.360414e-01 0.627 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 3.500703e-01 0.456 0 0
G2/M DNA replication checkpoint R-HSA-69478 3.500703e-01 0.456 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.500703e-01 0.456 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 1.906516e-01 0.720 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.020457e-01 0.520 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 3.020457e-01 0.520 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 3.020457e-01 0.520 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 3.020457e-01 0.520 0 0
Erythropoietin activates RAS R-HSA-9027284 2.655999e-01 0.576 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.655999e-01 0.576 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.655999e-01 0.576 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.361838e-01 0.627 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 1.906254e-01 0.720 0 0
Formation of the Early Elongation Complex R-HSA-113418 1.906254e-01 0.720 0 0
Negative regulation of MET activity R-HSA-6807004 2.615188e-01 0.582 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 2.957796e-01 0.529 0 0
Phosphorylation of the APC/C R-HSA-176412 2.957796e-01 0.529 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 3.391939e-01 0.470 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 3.391939e-01 0.470 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 3.391939e-01 0.470 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 3.986472e-01 0.399 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 3.986472e-01 0.399 0 0
PTK6 Expression R-HSA-8849473 3.986472e-01 0.399 0 0
TRIF-mediated programmed cell death R-HSA-2562578 3.986472e-01 0.399 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 3.986472e-01 0.399 0 0
SOS-mediated signalling R-HSA-112412 3.986472e-01 0.399 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 3.986472e-01 0.399 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 3.986472e-01 0.399 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.965718e-01 0.304 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 4.965718e-01 0.304 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.965718e-01 0.304 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 4.965718e-01 0.304 0 0
Defective GSS causes GSS deficiency R-HSA-5579006 4.965718e-01 0.304 0 0
Invadopodia formation R-HSA-8941237 4.965718e-01 0.304 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.965718e-01 0.304 0 0
Activation of the pre-replicative complex R-HSA-68962 2.290258e-01 0.640 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.874403e-01 0.541 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 2.022958e-01 0.694 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.263508e-01 0.486 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 3.263508e-01 0.486 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 2.785915e-01 0.555 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.762031e-01 0.425 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 2.132039e-01 0.671 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 2.355600e-01 0.628 0 0
HIV Transcription Initiation R-HSA-167161 2.355600e-01 0.628 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 2.355600e-01 0.628 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.019433e-01 0.520 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.019433e-01 0.520 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 3.570979e-01 0.447 0 0
Meiotic synapsis R-HSA-1221632 2.223096e-01 0.653 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 2.706125e-01 0.568 0 0
HIV elongation arrest and recovery R-HSA-167287 3.256333e-01 0.487 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.256333e-01 0.487 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 4.127672e-01 0.384 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 4.127672e-01 0.384 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.871342e-01 0.728 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.878213e-01 0.411 0 0
Ephrin signaling R-HSA-3928664 3.878213e-01 0.411 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 3.672529e-01 0.435 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 3.672529e-01 0.435 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.495595e-01 0.456 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 3.339318e-01 0.476 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 3.198790e-01 0.495 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 3.070784e-01 0.513 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.126813e-01 0.505 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.736226e-01 0.428 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.940772e-01 0.404 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 3.940772e-01 0.404 0 0
Deadenylation of mRNA R-HSA-429947 3.940772e-01 0.404 0 0
Regulation of signaling by CBL R-HSA-912631 4.183393e-01 0.378 0 0
E2F mediated regulation of DNA replication R-HSA-113510 4.183393e-01 0.378 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 4.183393e-01 0.378 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 4.486261e-01 0.348 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.901607e-01 0.310 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.611521e-01 0.251 0 0
HCN channels R-HSA-1296061 5.611521e-01 0.251 0 0
ATP sensitive Potassium channels R-HSA-1296025 5.611521e-01 0.251 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 5.611521e-01 0.251 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.611521e-01 0.251 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 5.611521e-01 0.251 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.317242e-01 0.635 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 3.302829e-01 0.481 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.302829e-01 0.481 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 3.778404e-01 0.423 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 3.284554e-01 0.484 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 4.835637e-01 0.316 0 0
Spry regulation of FGF signaling R-HSA-1295596 4.835637e-01 0.316 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 4.835637e-01 0.316 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 4.835637e-01 0.316 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 4.835637e-01 0.316 0 0
Regulation of necroptotic cell death R-HSA-5675482 4.457049e-01 0.351 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 4.781247e-01 0.320 0 0
DNA replication initiation R-HSA-68952 5.325223e-01 0.274 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 5.325223e-01 0.274 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 4.402082e-01 0.356 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 5.174048e-01 0.286 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 4.623956e-01 0.335 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.592934e-01 0.338 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 4.928331e-01 0.307 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 4.873589e-01 0.312 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 4.825593e-01 0.316 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.970791e-01 0.304 0 0
Signaling by Erythropoietin R-HSA-9006335 5.245286e-01 0.280 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 5.500111e-01 0.260 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 5.500111e-01 0.260 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 6.174513e-01 0.209 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 6.174513e-01 0.209 0 0
IRS activation R-HSA-74713 6.174513e-01 0.209 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 6.174513e-01 0.209 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 6.174513e-01 0.209 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 6.174513e-01 0.209 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 6.174513e-01 0.209 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 6.174513e-01 0.209 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 5.046511e-01 0.297 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.157033e-01 0.288 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 5.627870e-01 0.250 0 0
Interleukin receptor SHC signaling R-HSA-912526 5.627870e-01 0.250 0 0
Degradation of DVL R-HSA-4641258 5.607313e-01 0.251 0 0
Downstream signal transduction R-HSA-186763 5.732878e-01 0.242 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 5.795758e-01 0.237 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 5.823955e-01 0.235 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 6.097587e-01 0.215 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.905385e-01 0.229 0 0
Nucleosome assembly R-HSA-774815 5.905385e-01 0.229 0 0
Regulation of PTEN stability and activity R-HSA-8948751 5.979622e-01 0.223 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 5.979622e-01 0.223 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 6.048220e-01 0.218 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 6.111307e-01 0.214 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.111307e-01 0.214 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.148270e-01 0.211 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 6.439003e-01 0.191 0 0
MET activates RAS signaling R-HSA-8851805 6.445658e-01 0.191 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 6.445658e-01 0.191 0 0
IRAK1 recruits IKK complex R-HSA-937039 6.445658e-01 0.191 0 0
Leading Strand Synthesis R-HSA-69109 6.445658e-01 0.191 0 0
Polymerase switching R-HSA-69091 6.445658e-01 0.191 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 6.445658e-01 0.191 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 6.445658e-01 0.191 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 6.628302e-01 0.179 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 6.628302e-01 0.179 0 0
Transcription of the HIV genome R-HSA-167172 2.505022e-01 0.601 0 0
EGFR downregulation R-HSA-182971 3.977274e-01 0.400 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.213802e-01 0.283 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.213802e-01 0.283 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 3.263508e-01 0.486 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.591777e-01 0.586 0 0
HIV Transcription Elongation R-HSA-167169 3.198790e-01 0.495 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 6.439003e-01 0.191 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.404496e-01 0.468 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 3.878213e-01 0.411 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 6.411581e-01 0.193 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 3.711300e-01 0.430 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 5.071219e-01 0.295 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 3.711300e-01 0.430 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 3.711300e-01 0.430 0 0
Nucleotide Excision Repair R-HSA-5696398 5.393069e-01 0.268 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.127672e-01 0.384 0 0
Integrin signaling R-HSA-354192 6.192942e-01 0.208 0 0
mRNA Capping R-HSA-72086 5.245286e-01 0.280 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.484886e-01 0.348 0 0
Regulation of CDH11 function R-HSA-9762292 5.325223e-01 0.274 0 0
Signaling by ERBB2 R-HSA-1227986 4.563945e-01 0.341 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.797564e-01 0.745 0 0
p75NTR recruits signalling complexes R-HSA-209543 6.445658e-01 0.191 0 0
G1 Phase R-HSA-69236 2.886930e-01 0.540 0 0
Cyclin D associated events in G1 R-HSA-69231 2.886930e-01 0.540 0 0
RNA Polymerase III Transcription R-HSA-74158 3.778404e-01 0.423 0 0
Synaptic adhesion-like molecules R-HSA-8849932 3.878213e-01 0.411 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.198790e-01 0.495 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 3.570979e-01 0.447 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.038232e-01 0.691 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 4.486261e-01 0.348 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.492264e-01 0.260 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 6.216542e-01 0.206 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 6.083504e-01 0.216 0 0
DNA Replication Pre-Initiation R-HSA-69002 3.092360e-01 0.510 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 2.287947e-01 0.641 0 0
Regulation of the apoptosome activity R-HSA-9627069 5.325223e-01 0.274 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 6.097587e-01 0.215 0 0
Signaling by BMP R-HSA-201451 3.019433e-01 0.520 0 0
Interleukin-15 signaling R-HSA-8983432 6.445658e-01 0.191 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 3.878213e-01 0.411 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.602481e-01 0.585 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 2.651123e-01 0.577 0 0
Signaling by Activin R-HSA-1502540 2.655999e-01 0.576 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 3.019433e-01 0.520 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 4.454595e-01 0.351 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.865377e-01 0.729 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 2.999930e-01 0.523 0 0
Signaling by EGFR R-HSA-177929 3.840291e-01 0.416 0 0
Formation of apoptosome R-HSA-111458 5.325223e-01 0.274 0 0
Switching of origins to a post-replicative state R-HSA-69052 4.346802e-01 0.362 0 0
Clathrin-mediated endocytosis R-HSA-8856828 4.517889e-01 0.345 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.328932e-01 0.364 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.290258e-01 0.640 0 0
RNA Polymerase I Transcription R-HSA-73864 2.099147e-01 0.678 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.438660e-01 0.464 0 0
Hedgehog 'off' state R-HSA-5610787 5.585275e-01 0.253 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 6.097587e-01 0.215 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 3.736226e-01 0.428 0 0
Cilium Assembly R-HSA-5617833 4.273072e-01 0.369 0 0
NTRK3 as a dependence receptor R-HSA-9603505 3.375187e-01 0.472 0 0
mTORC1-mediated signalling R-HSA-166208 1.906516e-01 0.720 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.022958e-01 0.694 0 0
Adrenoceptors R-HSA-390696 4.454595e-01 0.351 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 3.672529e-01 0.435 0 0
Meiosis R-HSA-1500620 2.153064e-01 0.667 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.345270e-01 0.630 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 4.901607e-01 0.310 0 0
Regulation of gap junction activity R-HSA-191650 5.611521e-01 0.251 0 0
Telomere C-strand synthesis initiation R-HSA-174430 4.835637e-01 0.316 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 4.734887e-01 0.325 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 5.353727e-01 0.271 0 0
Passive transport by Aquaporins R-HSA-432047 5.500111e-01 0.260 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 5.379321e-01 0.269 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.504262e-01 0.601 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.504262e-01 0.601 0 0
Nuclear RNA decay R-HSA-9930044 1.724363e-01 0.763 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.858190e-01 0.414 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 6.192942e-01 0.208 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 4.509737e-01 0.346 0 0
Signaling by Hedgehog R-HSA-5358351 4.660370e-01 0.332 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 2.038232e-01 0.691 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.271396e-01 0.644 0 0
Signal attenuation R-HSA-74749 5.325223e-01 0.274 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 4.648113e-01 0.333 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 6.445658e-01 0.191 0 0
TNF signaling R-HSA-75893 5.157033e-01 0.288 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.700918e-01 0.244 0 0
Organelle biogenesis and maintenance R-HSA-1852241 2.796621e-01 0.553 0 0
Sema4D in semaphorin signaling R-HSA-400685 4.207991e-01 0.376 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 5.732878e-01 0.242 0 0
Signaling by Nuclear Receptors R-HSA-9006931 4.393961e-01 0.357 0 0
Developmental Biology R-HSA-1266738 5.891967e-01 0.230 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 5.433563e-01 0.265 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 2.497806e-01 0.602 0 0
Calcineurin activates NFAT R-HSA-2025928 2.287947e-01 0.641 0 0
Signaling by NODAL R-HSA-1181150 2.615188e-01 0.582 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 6.174513e-01 0.209 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 6.174513e-01 0.209 0 0
PTK6 Down-Regulation R-HSA-8849472 6.174513e-01 0.209 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 5.627870e-01 0.250 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 6.097587e-01 0.215 0 0
Amino acids regulate mTORC1 R-HSA-9639288 5.979622e-01 0.223 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 6.126094e-01 0.213 0 0
Signaling by FGFR1 in disease R-HSA-5655302 5.087087e-01 0.294 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 2.201050e-01 0.657 0 0
RAF/MAP kinase cascade R-HSA-5673001 4.843538e-01 0.315 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.613899e-01 0.583 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.613899e-01 0.583 0 0
RMTs methylate histone arginines R-HSA-3214858 2.886930e-01 0.540 0 0
Regulation of TNFR1 signaling R-HSA-5357905 4.623956e-01 0.335 0 0
Oncogene Induced Senescence R-HSA-2559585 3.558234e-01 0.449 0 0
Axon guidance R-HSA-422475 5.928137e-01 0.227 0 0
Nervous system development R-HSA-9675108 6.367540e-01 0.196 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 5.325223e-01 0.274 0 0
Mitochondrial biogenesis R-HSA-1592230 2.669182e-01 0.574 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 6.478041e-01 0.189 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 1.996486e-01 0.700 0 0
Disorders of Nervous System Development R-HSA-9697154 1.797564e-01 0.745 0 0
Pervasive developmental disorders R-HSA-9005895 1.797564e-01 0.745 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.797564e-01 0.745 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 3.002224e-01 0.523 0 0
Inhibition of nitric oxide production R-HSA-9636249 4.965718e-01 0.304 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.785915e-01 0.555 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 5.724090e-01 0.242 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.226329e-01 0.491 0 0
Reproduction R-HSA-1474165 2.140969e-01 0.669 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 6.478041e-01 0.189 0 0
ESR-mediated signaling R-HSA-8939211 1.856531e-01 0.731 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.939299e-01 0.226 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 5.076651e-01 0.294 0 0
Neurofascin interactions R-HSA-447043 3.500703e-01 0.456 0 0
ERK/MAPK targets R-HSA-198753 2.874403e-01 0.541 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.186820e-01 0.660 0 0
Vasopressin-like receptors R-HSA-388479 5.611521e-01 0.251 0 0
Recycling pathway of L1 R-HSA-437239 6.287731e-01 0.202 0 0
Rap1 signalling R-HSA-392517 6.395204e-01 0.194 0 0
Diseases of programmed cell death R-HSA-9645723 2.641972e-01 0.578 0 0
MAPK family signaling cascades R-HSA-5683057 4.272194e-01 0.369 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 5.127082e-01 0.290 0 0
MyD88-independent TLR4 cascade R-HSA-166166 5.076651e-01 0.294 0 0
Semaphorin interactions R-HSA-373755 5.098904e-01 0.293 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.397385e-01 0.357 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 2.360414e-01 0.627 0 0
Cell junction organization R-HSA-446728 2.790535e-01 0.554 0 0
Signaling by VEGF R-HSA-194138 4.589526e-01 0.338 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 3.678025e-01 0.434 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 5.892912e-01 0.230 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 4.884707e-01 0.311 0 0
Metabolism of RNA R-HSA-8953854 2.502812e-01 0.602 0 0
Membrane Trafficking R-HSA-199991 5.493819e-01 0.260 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 6.148270e-01 0.211 0 0
Adherens junctions interactions R-HSA-418990 5.000801e-01 0.301 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.840291e-01 0.416 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 5.926456e-01 0.227 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 5.795412e-01 0.237 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.439280e-01 0.353 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 4.277293e-01 0.369 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 4.277293e-01 0.369 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 4.277293e-01 0.369 0 0
NrCAM interactions R-HSA-447038 2.497806e-01 0.602 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.497806e-01 0.602 0 0
Sensory perception of salty taste R-HSA-9730628 3.002224e-01 0.523 0 0
TGFBR3 regulates activin signaling R-HSA-9839406 4.224927e-01 0.374 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 4.224927e-01 0.374 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 4.224927e-01 0.374 0 0
Regulation of KIT signaling R-HSA-1433559 2.360414e-01 0.627 0 0
CREB phosphorylation R-HSA-199920 3.500703e-01 0.456 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 2.094960e-01 0.679 0 0
MET activates STAT3 R-HSA-8875791 4.965718e-01 0.304 0 0
Activation of BMF and translocation to mitochondria R-HSA-139910 4.965718e-01 0.304 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 4.965718e-01 0.304 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 4.454595e-01 0.351 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 4.127672e-01 0.384 0 0
Unwinding of DNA R-HSA-176974 4.901607e-01 0.310 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 5.611521e-01 0.251 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 5.611521e-01 0.251 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 4.835637e-01 0.316 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 5.071219e-01 0.295 0 0
MAP kinase activation R-HSA-450294 4.743584e-01 0.324 0 0
Bicarbonate transporters R-HSA-425381 5.724090e-01 0.242 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 6.174513e-01 0.209 0 0
Reelin signalling pathway R-HSA-8866376 6.174513e-01 0.209 0 0
NTRK2 activates RAC1 R-HSA-9032759 6.174513e-01 0.209 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 5.538286e-01 0.257 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 5.538286e-01 0.257 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.732878e-01 0.242 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 6.159395e-01 0.210 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 6.577780e-01 0.182 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 6.411581e-01 0.193 0 0
Cell-Cell communication R-HSA-1500931 4.093958e-01 0.388 0 0
Interleukin-17 signaling R-HSA-448424 5.046511e-01 0.297 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 3.849150e-01 0.415 0 0
Programmed Cell Death R-HSA-5357801 3.093882e-01 0.509 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 6.393504e-01 0.194 0 0
Signaling by FGFR4 in disease R-HSA-5655291 4.486261e-01 0.348 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.863694e-01 0.232 0 0
Pexophagy R-HSA-9664873 2.651123e-01 0.577 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 6.432265e-01 0.192 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.724836e-01 0.763 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 2.655999e-01 0.576 0 0
Neurodegenerative Diseases R-HSA-8863678 2.333200e-01 0.632 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.333200e-01 0.632 0 0
HIV Life Cycle R-HSA-162587 1.772172e-01 0.751 0 0
Uptake and function of anthrax toxins R-HSA-5210891 1.878789e-01 0.726 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 5.812780e-01 0.236 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 5.812780e-01 0.236 0 0
PI Metabolism R-HSA-1483255 4.840127e-01 0.315 0 0
Kinesins R-HSA-983189 2.300145e-01 0.638 0 0
MDK and PTN in ALK signaling R-HSA-9851151 5.611521e-01 0.251 0 0
TRP channels R-HSA-3295583 4.473043e-01 0.349 0 0
Long-term potentiation R-HSA-9620244 6.148270e-01 0.211 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 5.325223e-01 0.274 0 0
Negative regulation of FLT3 R-HSA-9706369 5.174048e-01 0.286 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.843871e-01 0.734 0 0
Signaling by PTK6 R-HSA-8848021 1.843871e-01 0.734 0 0
Formation of paraxial mesoderm R-HSA-9793380 6.048220e-01 0.218 0 0
HIV Infection R-HSA-162906 4.475872e-01 0.349 0 0
Signaling by NOTCH2 R-HSA-1980145 6.622225e-01 0.179 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 4.454595e-01 0.351 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 5.611521e-01 0.251 0 0
Formation of intermediate mesoderm R-HSA-9761174 5.325223e-01 0.274 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.109091e-01 0.676 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 5.046511e-01 0.297 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 2.287947e-01 0.641 0 0
Formation of the nephric duct R-HSA-9830364 6.148270e-01 0.211 0 0
Signaling by ALK in cancer R-HSA-9700206 2.109091e-01 0.676 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.229401e-01 0.206 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.807124e-01 0.419 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 4.401021e-01 0.356 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.375187e-01 0.472 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 2.651123e-01 0.577 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.965718e-01 0.304 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.137989e-01 0.503 0 0
Maturation of nucleoprotein R-HSA-9683610 4.127672e-01 0.384 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 3.878213e-01 0.411 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 4.486261e-01 0.348 0 0
Sensory perception of sour taste R-HSA-9729555 5.611521e-01 0.251 0 0
Creatine metabolism R-HSA-71288 4.484886e-01 0.348 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 4.781247e-01 0.320 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 5.325223e-01 0.274 0 0
Synthesis of PI R-HSA-1483226 5.724090e-01 0.242 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 5.892912e-01 0.230 0 0
Metalloprotease DUBs R-HSA-5689901 6.393504e-01 0.194 0 0
FLT3 signaling in disease R-HSA-9682385 2.423595e-01 0.616 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.935388e-01 0.713 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.287947e-01 0.641 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 6.628302e-01 0.179 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 2.287947e-01 0.641 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.901607e-01 0.310 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 4.835637e-01 0.316 0 0
Signaling by ALK R-HSA-201556 4.439280e-01 0.353 0 0
Tie2 Signaling R-HSA-210993 6.111307e-01 0.214 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 6.471163e-01 0.189 0 0
Host Interactions of HIV factors R-HSA-162909 5.253482e-01 0.280 0 0
Netrin-1 signaling R-HSA-373752 2.886930e-01 0.540 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.986472e-01 0.399 0 0
Sodium/Proton exchangers R-HSA-425986 4.454595e-01 0.351 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 5.611521e-01 0.251 0 0
Dopamine receptors R-HSA-390651 5.611521e-01 0.251 0 0
Anchoring fibril formation R-HSA-2214320 6.097587e-01 0.215 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 6.192942e-01 0.208 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 6.393504e-01 0.194 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 4.781247e-01 0.320 0 0
Other interleukin signaling R-HSA-449836 6.395204e-01 0.194 0 0
Signaling by SCF-KIT R-HSA-1433557 5.504234e-01 0.259 0 0
Inositol phosphate metabolism R-HSA-1483249 3.463278e-01 0.461 0 0
Gene Silencing by RNA R-HSA-211000 2.851952e-01 0.545 0 0
Glycolysis R-HSA-70171 2.707172e-01 0.567 0 0
Maturation of nucleoprotein R-HSA-9694631 6.395204e-01 0.194 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 4.171554e-01 0.380 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 6.111307e-01 0.214 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.497806e-01 0.602 0 0
Interleukin-38 signaling R-HSA-9007892 5.611521e-01 0.251 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 6.174513e-01 0.209 0 0
Signaling by LTK R-HSA-9842663 6.445658e-01 0.191 0 0
Interleukin-7 signaling R-HSA-1266695 6.148270e-01 0.211 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 5.812780e-01 0.236 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 4.951758e-01 0.305 0 0
Glucose metabolism R-HSA-70326 5.297264e-01 0.276 0 0
tRNA processing in the nucleus R-HSA-6784531 2.591777e-01 0.586 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 6.174513e-01 0.209 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 6.381038e-01 0.195 0 0
OAS antiviral response R-HSA-8983711 6.445658e-01 0.191 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.753475e-01 0.756 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 6.174513e-01 0.209 0 0
Degradation of CRY and PER proteins R-HSA-9932298 6.631407e-01 0.178 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 6.631407e-01 0.178 0 0
Cell-cell junction organization R-HSA-421270 6.640809e-01 0.178 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 6.664207e-01 0.176 0 0
Co-inhibition by CTLA4 R-HSA-389513 6.664207e-01 0.176 0 0
Signal transduction by L1 R-HSA-445144 6.664207e-01 0.176 0 0
Nephrin family interactions R-HSA-373753 6.664207e-01 0.176 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.665308e-01 0.176 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 6.665308e-01 0.176 0 0
Phosphorylation of Emi1 R-HSA-176417 6.665308e-01 0.176 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.665308e-01 0.176 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 6.665308e-01 0.176 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.665308e-01 0.176 0 0
PKB-mediated events R-HSA-109703 6.665308e-01 0.176 0 0
PDE3B signalling R-HSA-165160 6.665308e-01 0.176 0 0
Signaling by MAPK mutants R-HSA-9652817 6.665308e-01 0.176 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.665308e-01 0.176 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 6.665308e-01 0.176 0 0
Ligand-receptor interactions R-HSA-5632681 6.665308e-01 0.176 0 0
Pentose phosphate pathway disease R-HSA-6791465 6.665308e-01 0.176 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.665308e-01 0.176 0 0
Synthesis of PS R-HSA-1483101 6.665308e-01 0.176 0 0
Formation of the Editosome R-HSA-75094 6.665308e-01 0.176 0 0
Relaxin receptors R-HSA-444821 6.665308e-01 0.176 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.665308e-01 0.176 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 6.665308e-01 0.176 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 6.665308e-01 0.176 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 6.768679e-01 0.169 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 6.768679e-01 0.169 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 6.768679e-01 0.169 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 6.789733e-01 0.168 0 0
Regulation of RAS by GAPs R-HSA-5658442 6.821530e-01 0.166 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 6.823227e-01 0.166 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 6.823227e-01 0.166 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 6.852467e-01 0.164 0 0
Signaling by NOTCH4 R-HSA-9013694 6.869817e-01 0.163 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 6.918246e-01 0.160 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 6.918246e-01 0.160 0 0
Basigin interactions R-HSA-210991 6.918246e-01 0.160 0 0
Signalling to RAS R-HSA-167044 6.918246e-01 0.160 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 6.963327e-01 0.157 0 0
Signaling by ROBO receptors R-HSA-376176 6.985398e-01 0.156 0 0
HSF1-dependent transactivation R-HSA-3371571 6.988173e-01 0.156 0 0
Meiotic recombination R-HSA-912446 6.988173e-01 0.156 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 6.989737e-01 0.156 0 0
Signaling by FGFR4 R-HSA-5654743 6.996096e-01 0.155 0 0
Defective pyroptosis R-HSA-9710421 6.996096e-01 0.155 0 0
L1CAM interactions R-HSA-373760 7.016501e-01 0.154 0 0
PRC2 methylates histones and DNA R-HSA-212300 7.018782e-01 0.154 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 7.018782e-01 0.154 0 0
GPVI-mediated activation cascade R-HSA-114604 7.018782e-01 0.154 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.025461e-01 0.153 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 7.065907e-01 0.151 0 0
DNA methylation R-HSA-5334118 7.065907e-01 0.151 0 0
Late endosomal microautophagy R-HSA-9615710 7.065907e-01 0.151 0 0
Platelet calcium homeostasis R-HSA-418360 7.065907e-01 0.151 0 0
Removal of the Flap Intermediate R-HSA-69166 7.067348e-01 0.151 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 7.067348e-01 0.151 0 0
CRMPs in Sema3A signaling R-HSA-399956 7.067348e-01 0.151 0 0
Retrograde neurotrophin signalling R-HSA-177504 7.067348e-01 0.151 0 0
Signaling by LTK in cancer R-HSA-9842640 7.093161e-01 0.149 0 0
Erythropoietin activates STAT5 R-HSA-9027283 7.093161e-01 0.149 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 7.093161e-01 0.149 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 7.093161e-01 0.149 0 0
MET Receptor Activation R-HSA-6806942 7.093161e-01 0.149 0 0
Agmatine biosynthesis R-HSA-351143 7.093161e-01 0.149 0 0
NADPH regeneration R-HSA-389542 7.093161e-01 0.149 0 0
Nef and signal transduction R-HSA-164944 7.093161e-01 0.149 0 0
CREB3 factors activate genes R-HSA-8874211 7.093161e-01 0.149 0 0
Interleukin-1 family signaling R-HSA-446652 7.145617e-01 0.146 0 0
Orc1 removal from chromatin R-HSA-68949 7.148987e-01 0.146 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 7.148987e-01 0.146 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 7.157415e-01 0.145 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 7.157415e-01 0.145 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.157415e-01 0.145 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.157415e-01 0.145 0 0
Degradation of AXIN R-HSA-4641257 7.204490e-01 0.142 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 7.204490e-01 0.142 0 0
Collagen chain trimerization R-HSA-8948216 7.204490e-01 0.142 0 0
DAP12 signaling R-HSA-2424491 7.268623e-01 0.139 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 7.268623e-01 0.139 0 0
Cellular responses to stress R-HSA-2262752 7.278606e-01 0.138 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 7.279636e-01 0.138 0 0
Collagen degradation R-HSA-1442490 7.287324e-01 0.137 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 7.333276e-01 0.135 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 7.333276e-01 0.135 0 0
Signaling by FGFR3 R-HSA-5654741 7.333276e-01 0.135 0 0
Translesion synthesis by REV1 R-HSA-110312 7.342595e-01 0.134 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 7.342595e-01 0.134 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 7.342595e-01 0.134 0 0
Processive synthesis on the lagging strand R-HSA-69183 7.342595e-01 0.134 0 0
p75NTR signals via NF-kB R-HSA-193639 7.342595e-01 0.134 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 7.342595e-01 0.134 0 0
FASTK family proteins regulate processing and stability of mitochondrial RNAs R-HSA-9837092 7.342595e-01 0.134 0 0
p38MAPK events R-HSA-171007 7.342595e-01 0.134 0 0
Co-inhibition by PD-1 R-HSA-389948 7.375745e-01 0.132 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 7.381941e-01 0.132 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.381941e-01 0.132 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 7.466140e-01 0.127 0 0
Glycoprotein hormones R-HSA-209822 7.466140e-01 0.127 0 0
IFNG signaling activates MAPKs R-HSA-9732724 7.466140e-01 0.127 0 0
Recycling of eIF2:GDP R-HSA-72731 7.466140e-01 0.127 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 7.466140e-01 0.127 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 7.466140e-01 0.127 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 7.466140e-01 0.127 0 0
mRNA Editing: C to U Conversion R-HSA-72200 7.466140e-01 0.127 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.466140e-01 0.127 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 7.466140e-01 0.127 0 0
CHL1 interactions R-HSA-447041 7.466140e-01 0.127 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.466140e-01 0.127 0 0
Maturation of replicase proteins R-HSA-9694301 7.466140e-01 0.127 0 0
Synthesis of DNA R-HSA-69239 7.525854e-01 0.123 0 0
Chromosome Maintenance R-HSA-73886 7.540134e-01 0.123 0 0
Stabilization of p53 R-HSA-69541 7.550694e-01 0.122 0 0
Carnitine shuttle R-HSA-200425 7.592161e-01 0.120 0 0
Growth hormone receptor signaling R-HSA-982772 7.592161e-01 0.120 0 0
Translesion synthesis by POLI R-HSA-5656121 7.595514e-01 0.119 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 7.595514e-01 0.119 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 7.595514e-01 0.119 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 7.595514e-01 0.119 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 7.598023e-01 0.119 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 7.629254e-01 0.118 0 0
Stimuli-sensing channels R-HSA-2672351 7.629254e-01 0.118 0 0
Post NMDA receptor activation events R-HSA-438064 7.638389e-01 0.117 0 0
DNA strand elongation R-HSA-69190 7.642264e-01 0.117 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 7.642264e-01 0.117 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 7.642711e-01 0.117 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 7.642711e-01 0.117 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 7.711312e-01 0.113 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 7.711312e-01 0.113 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 7.711312e-01 0.113 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 7.732659e-01 0.112 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.739065e-01 0.111 0 0
TNFs bind their physiological receptors R-HSA-5669034 7.788501e-01 0.109 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 7.788501e-01 0.109 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 7.788761e-01 0.109 0 0
Ca2+ pathway R-HSA-4086398 7.788761e-01 0.109 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 7.791281e-01 0.108 0 0
RSK activation R-HSA-444257 7.791281e-01 0.108 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.791281e-01 0.108 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.791281e-01 0.108 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 7.791281e-01 0.108 0 0
Regulation by c-FLIP R-HSA-3371378 7.791281e-01 0.108 0 0
Formation of annular gap junctions R-HSA-196025 7.791281e-01 0.108 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 7.791281e-01 0.108 0 0
Dimerization of procaspase-8 R-HSA-69416 7.791281e-01 0.108 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.791281e-01 0.108 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.791281e-01 0.108 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 7.813544e-01 0.107 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 7.813544e-01 0.107 0 0
FGFR1 mutant receptor activation R-HSA-1839124 7.813544e-01 0.107 0 0
Cellular response to hypoxia R-HSA-1234174 7.820670e-01 0.107 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 7.827300e-01 0.106 0 0
Translesion synthesis by POLK R-HSA-5655862 7.827300e-01 0.106 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 7.827300e-01 0.106 0 0
Glycine degradation R-HSA-6783984 7.827300e-01 0.106 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 7.827300e-01 0.106 0 0
Fibronectin matrix formation R-HSA-1566977 7.827300e-01 0.106 0 0
tRNA modification in the mitochondrion R-HSA-6787450 7.827300e-01 0.106 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 7.827300e-01 0.106 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 7.828235e-01 0.106 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 7.863760e-01 0.104 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 7.863760e-01 0.104 0 0
Signaling by FGFR in disease R-HSA-1226099 7.904603e-01 0.102 0 0
Signaling by ERBB4 R-HSA-1236394 7.904603e-01 0.102 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 7.943556e-01 0.100 0 0
Laminin interactions R-HSA-3000157 7.971453e-01 0.098 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 7.974787e-01 0.098 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.974787e-01 0.098 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 8.008195e-01 0.096 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 8.008195e-01 0.096 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 8.008195e-01 0.096 0 0
RSV-host interactions R-HSA-9833110 8.024917e-01 0.096 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 8.039213e-01 0.095 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.039213e-01 0.095 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 8.039213e-01 0.095 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 8.039213e-01 0.095 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.039213e-01 0.095 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.039213e-01 0.095 0 0
PPARA activates gene expression R-HSA-1989781 8.074119e-01 0.093 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 8.074119e-01 0.093 0 0
MAPK1 (ERK2) activation R-HSA-112411 8.074717e-01 0.093 0 0
CASP8 activity is inhibited R-HSA-5218900 8.074717e-01 0.093 0 0
Gap junction degradation R-HSA-190873 8.074717e-01 0.093 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 8.074717e-01 0.093 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 8.074717e-01 0.093 0 0
ARMS-mediated activation R-HSA-170984 8.074717e-01 0.093 0 0
Regulation of signaling by NODAL R-HSA-1433617 8.074717e-01 0.093 0 0
mRNA Editing R-HSA-75072 8.074717e-01 0.093 0 0
Interleukin-1 processing R-HSA-448706 8.074717e-01 0.093 0 0
Regulated proteolysis of p75NTR R-HSA-193692 8.074717e-01 0.093 0 0
Lipophagy R-HSA-9613354 8.074717e-01 0.093 0 0
Cellular response to mitochondrial stress R-HSA-9840373 8.074717e-01 0.093 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 8.074717e-01 0.093 0 0
Regulation of beta-cell development R-HSA-186712 8.109919e-01 0.091 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.126289e-01 0.090 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.126289e-01 0.090 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.126289e-01 0.090 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 8.126289e-01 0.090 0 0
MET activates PTK2 signaling R-HSA-8874081 8.141563e-01 0.089 0 0
Signaling by EGFR in Cancer R-HSA-1643713 8.141563e-01 0.089 0 0
Myogenesis R-HSA-525793 8.141563e-01 0.089 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 8.144804e-01 0.089 0 0
Regulated Necrosis R-HSA-5218859 8.167109e-01 0.088 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 8.180124e-01 0.087 0 0
Hedgehog ligand biogenesis R-HSA-5358346 8.180124e-01 0.087 0 0
SARS-CoV-1-host interactions R-HSA-9692914 8.203993e-01 0.086 0 0
Apoptotic factor-mediated response R-HSA-111471 8.232535e-01 0.084 0 0
Mismatch Repair R-HSA-5358508 8.232535e-01 0.084 0 0
PKA activation in glucagon signalling R-HSA-164378 8.232535e-01 0.084 0 0
Chaperone Mediated Autophagy R-HSA-9613829 8.232535e-01 0.084 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 8.268377e-01 0.083 0 0
Interaction between L1 and Ankyrins R-HSA-445095 8.299413e-01 0.081 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 8.299413e-01 0.081 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 8.299413e-01 0.081 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 8.299413e-01 0.081 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.299413e-01 0.081 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 8.299413e-01 0.081 0 0
Maturation of hRSV A proteins R-HSA-9828806 8.299413e-01 0.081 0 0
SARS-CoV-2-host interactions R-HSA-9705683 8.301730e-01 0.081 0 0
MAPK3 (ERK1) activation R-HSA-110056 8.321795e-01 0.080 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 8.321795e-01 0.080 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 8.321795e-01 0.080 0 0
PI3K/AKT activation R-HSA-198203 8.321795e-01 0.080 0 0
Peptide hormone biosynthesis R-HSA-209952 8.321795e-01 0.080 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 8.321795e-01 0.080 0 0
Receptor Mediated Mitophagy R-HSA-8934903 8.321795e-01 0.080 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 8.321795e-01 0.080 0 0
Sperm Motility And Taxes R-HSA-1300642 8.321795e-01 0.080 0 0
Signaling by Leptin R-HSA-2586552 8.321795e-01 0.080 0 0
PCP/CE pathway R-HSA-4086400 8.323310e-01 0.080 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.382108e-01 0.077 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 8.395414e-01 0.076 0 0
EPHB-mediated forward signaling R-HSA-3928662 8.395414e-01 0.076 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.401402e-01 0.076 0 0
Calmodulin induced events R-HSA-111933 8.401402e-01 0.076 0 0
CaM pathway R-HSA-111997 8.401402e-01 0.076 0 0
Regulation of TP53 Degradation R-HSA-6804757 8.401402e-01 0.076 0 0
Translesion Synthesis by POLH R-HSA-110320 8.408547e-01 0.075 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 8.408547e-01 0.075 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 8.408547e-01 0.075 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 8.408547e-01 0.075 0 0
Crosslinking of collagen fibrils R-HSA-2243919 8.408547e-01 0.075 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 8.408547e-01 0.075 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 8.408547e-01 0.075 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 8.408547e-01 0.075 0 0
STING mediated induction of host immune responses R-HSA-1834941 8.408547e-01 0.075 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 8.409288e-01 0.075 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 8.410021e-01 0.075 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.425689e-01 0.074 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 8.431956e-01 0.074 0 0
Signaling by PDGF R-HSA-186797 8.436374e-01 0.074 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.469597e-01 0.072 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 8.470366e-01 0.072 0 0
DNA Replication R-HSA-69306 8.497198e-01 0.071 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 8.509897e-01 0.070 0 0
Fanconi Anemia Pathway R-HSA-6783310 8.509897e-01 0.070 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 8.509897e-01 0.070 0 0
Translation initiation complex formation R-HSA-72649 8.515835e-01 0.070 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.525734e-01 0.069 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 8.525734e-01 0.069 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 8.529494e-01 0.069 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 8.537177e-01 0.069 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.537177e-01 0.069 0 0
Interleukin-2 signaling R-HSA-9020558 8.537177e-01 0.069 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.537177e-01 0.069 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 8.537177e-01 0.069 0 0
Ionotropic activity of kainate receptors R-HSA-451306 8.537177e-01 0.069 0 0
Hormone ligand-binding receptors R-HSA-375281 8.537177e-01 0.069 0 0
Transport of RCbl within the body R-HSA-9758890 8.537177e-01 0.069 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.537177e-01 0.069 0 0
LGI-ADAM interactions R-HSA-5682910 8.537177e-01 0.069 0 0
Suppression of apoptosis R-HSA-9635465 8.537177e-01 0.069 0 0
PECAM1 interactions R-HSA-210990 8.537177e-01 0.069 0 0
Selective autophagy R-HSA-9663891 8.546267e-01 0.068 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 8.568506e-01 0.067 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 8.568506e-01 0.067 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 8.568506e-01 0.067 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 8.568506e-01 0.067 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 8.568506e-01 0.067 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.580762e-01 0.066 0 0
DARPP-32 events R-HSA-180024 8.580762e-01 0.066 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.580762e-01 0.066 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 8.580762e-01 0.066 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 8.601354e-01 0.065 0 0
tRNA processing R-HSA-72306 8.602298e-01 0.065 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.617507e-01 0.065 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.705503e-01 0.060 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 8.710153e-01 0.060 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 8.710153e-01 0.060 0 0
Signaling by FGFR1 R-HSA-5654736 8.710153e-01 0.060 0 0
Ion homeostasis R-HSA-5578775 8.710153e-01 0.060 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 8.713634e-01 0.060 0 0
Lagging Strand Synthesis R-HSA-69186 8.713634e-01 0.060 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 8.718517e-01 0.060 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 8.724927e-01 0.059 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 8.724927e-01 0.059 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 8.724927e-01 0.059 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 8.724927e-01 0.059 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.724927e-01 0.059 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.724927e-01 0.059 0 0
NF-kB is activated and signals survival R-HSA-209560 8.724927e-01 0.059 0 0
ERKs are inactivated R-HSA-202670 8.724927e-01 0.059 0 0
DS-GAG biosynthesis R-HSA-2022923 8.724927e-01 0.059 0 0
Integration of provirus R-HSA-162592 8.724927e-01 0.059 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 8.749861e-01 0.058 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 8.751780e-01 0.058 0 0
Cellular response to starvation R-HSA-9711097 8.792933e-01 0.056 0 0
Co-stimulation by CD28 R-HSA-389356 8.813201e-01 0.055 0 0
Budding and maturation of HIV virion R-HSA-162588 8.820447e-01 0.055 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 8.820447e-01 0.055 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 8.820447e-01 0.055 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 8.845101e-01 0.053 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 8.845101e-01 0.053 0 0
Glutathione synthesis and recycling R-HSA-174403 8.845101e-01 0.053 0 0
Assembly Of The HIV Virion R-HSA-175474 8.845101e-01 0.053 0 0
Toll-like Receptor Cascades R-HSA-168898 8.850214e-01 0.053 0 0
Aggrephagy R-HSA-9646399 8.850440e-01 0.053 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 8.850440e-01 0.053 0 0
Interleukin-2 family signaling R-HSA-451927 8.850440e-01 0.053 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.850440e-01 0.053 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 8.882755e-01 0.051 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.888590e-01 0.051 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.888590e-01 0.051 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.888590e-01 0.051 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.888590e-01 0.051 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.888590e-01 0.051 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.888590e-01 0.051 0 0
Regulation of IFNG signaling R-HSA-877312 8.888590e-01 0.051 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.888590e-01 0.051 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.888590e-01 0.051 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.888590e-01 0.051 0 0
DNA Damage Bypass R-HSA-73893 8.901841e-01 0.051 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 8.926205e-01 0.049 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 8.926205e-01 0.049 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.943886e-01 0.048 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 8.943886e-01 0.048 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.964023e-01 0.047 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 8.964023e-01 0.047 0 0
FGFR2 alternative splicing R-HSA-6803529 8.964023e-01 0.047 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.964023e-01 0.047 0 0
Ethanol oxidation R-HSA-71384 8.964023e-01 0.047 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.966235e-01 0.047 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.984717e-01 0.046 0 0
Interleukin-1 signaling R-HSA-9020702 8.992864e-01 0.046 0 0
G-protein beta:gamma signalling R-HSA-397795 9.023370e-01 0.045 0 0
Recycling of bile acids and salts R-HSA-159418 9.023370e-01 0.045 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.030590e-01 0.044 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.030590e-01 0.044 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 9.031254e-01 0.044 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 9.031254e-01 0.044 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 9.031254e-01 0.044 0 0
CD28 dependent Vav1 pathway R-HSA-389359 9.031254e-01 0.044 0 0
Processing of SMDT1 R-HSA-8949664 9.031254e-01 0.044 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 9.031254e-01 0.044 0 0
Interleukin-6 signaling R-HSA-1059683 9.031254e-01 0.044 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 9.031254e-01 0.044 0 0
Influenza Infection R-HSA-168255 9.054811e-01 0.043 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.071454e-01 0.042 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.071454e-01 0.042 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.071454e-01 0.042 0 0
Syndecan interactions R-HSA-3000170 9.071454e-01 0.042 0 0
Formation of the ureteric bud R-HSA-9830674 9.071454e-01 0.042 0 0
COPII-mediated vesicle transport R-HSA-204005 9.089493e-01 0.041 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 9.089493e-01 0.041 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.104660e-01 0.041 0 0
Aquaporin-mediated transport R-HSA-445717 9.104660e-01 0.041 0 0
Ca-dependent events R-HSA-111996 9.110934e-01 0.040 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.110934e-01 0.040 0 0
Depyrimidination R-HSA-73928 9.110934e-01 0.040 0 0
Striated Muscle Contraction R-HSA-390522 9.112521e-01 0.040 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.112521e-01 0.040 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.134299e-01 0.039 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.134299e-01 0.039 0 0
Signaling by FGFR2 R-HSA-5654738 9.144034e-01 0.039 0 0
Physiological factors R-HSA-5578768 9.155612e-01 0.038 0 0
NRIF signals cell death from the nucleus R-HSA-205043 9.155612e-01 0.038 0 0
Malate-aspartate shuttle R-HSA-9856872 9.155612e-01 0.038 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 9.155612e-01 0.038 0 0
HDL assembly R-HSA-8963896 9.155612e-01 0.038 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 9.155612e-01 0.038 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.156535e-01 0.038 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.168383e-01 0.038 0 0
Complex III assembly R-HSA-9865881 9.168383e-01 0.038 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.185294e-01 0.037 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.194212e-01 0.036 0 0
NOD1/2 Signaling Pathway R-HSA-168638 9.194212e-01 0.036 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 9.222935e-01 0.035 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.230429e-01 0.035 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 9.246549e-01 0.034 0 0
Proteasome assembly R-HSA-9907900 9.254033e-01 0.034 0 0
DAP12 interactions R-HSA-2172127 9.254033e-01 0.034 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.255736e-01 0.034 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.255736e-01 0.034 0 0
Tight junction interactions R-HSA-420029 9.255736e-01 0.034 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.255736e-01 0.034 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.255736e-01 0.034 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 9.264013e-01 0.033 0 0
Protein lipoylation R-HSA-9857492 9.264013e-01 0.033 0 0
SHC1 events in EGFR signaling R-HSA-180336 9.264013e-01 0.033 0 0
DNA Damage Reversal R-HSA-73942 9.264013e-01 0.033 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 9.264013e-01 0.033 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 9.264013e-01 0.033 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 9.264013e-01 0.033 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 9.264013e-01 0.033 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 9.264013e-01 0.033 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 9.264013e-01 0.033 0 0
Protein methylation R-HSA-8876725 9.264013e-01 0.033 0 0
Other semaphorin interactions R-HSA-416700 9.264013e-01 0.033 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.264147e-01 0.033 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.268976e-01 0.033 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.268976e-01 0.033 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.268976e-01 0.033 0 0
Regulation of Apoptosis R-HSA-169911 9.268976e-01 0.033 0 0
IGF1R signaling cascade R-HSA-2428924 9.287295e-01 0.032 0 0
DAG and IP3 signaling R-HSA-1489509 9.317504e-01 0.031 0 0
Somitogenesis R-HSA-9824272 9.317504e-01 0.031 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.317504e-01 0.031 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.317504e-01 0.031 0 0
Attachment of bacteria to epithelial cells R-HSA-9638630 9.334373e-01 0.030 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.334373e-01 0.030 0 0
Urea cycle R-HSA-70635 9.334373e-01 0.030 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.334373e-01 0.030 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.334373e-01 0.030 0 0
Triglyceride catabolism R-HSA-163560 9.337320e-01 0.030 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.340421e-01 0.030 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 9.358503e-01 0.029 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 9.358503e-01 0.029 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 9.358503e-01 0.029 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 9.358503e-01 0.029 0 0
Fructose catabolism R-HSA-70350 9.358503e-01 0.029 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 9.358503e-01 0.029 0 0
Mineralocorticoid biosynthesis R-HSA-193993 9.358503e-01 0.029 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.365671e-01 0.028 0 0
HCMV Early Events R-HSA-9609690 9.366450e-01 0.028 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 9.376047e-01 0.028 0 0
Cellular responses to stimuli R-HSA-8953897 9.378376e-01 0.028 0 0
EPH-Ephrin signaling R-HSA-2682334 9.384820e-01 0.028 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.390005e-01 0.027 0 0
Cleavage of the damaged purine R-HSA-110331 9.399725e-01 0.027 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.399725e-01 0.027 0 0
Packaging Of Telomere Ends R-HSA-171306 9.405093e-01 0.027 0 0
Cristae formation R-HSA-8949613 9.405093e-01 0.027 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 9.405093e-01 0.027 0 0
Signaling by Interleukins R-HSA-449147 9.405734e-01 0.027 0 0
Autophagy R-HSA-9612973 9.420309e-01 0.026 0 0
IRS-mediated signalling R-HSA-112399 9.426514e-01 0.026 0 0
Kidney development R-HSA-9830369 9.436241e-01 0.025 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.440867e-01 0.025 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 9.440867e-01 0.025 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.440867e-01 0.025 0 0
Coenzyme A biosynthesis R-HSA-196783 9.440867e-01 0.025 0 0
Scavenging by Class B Receptors R-HSA-3000471 9.440867e-01 0.025 0 0
Synthesis of PG R-HSA-1483148 9.440867e-01 0.025 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.440867e-01 0.025 0 0
HCMV Late Events R-HSA-9610379 9.450614e-01 0.025 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.456647e-01 0.024 0 0
Depurination R-HSA-73927 9.456647e-01 0.024 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.456647e-01 0.024 0 0
Macroautophagy R-HSA-1632852 9.464880e-01 0.024 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 9.468630e-01 0.024 0 0
Telomere Extension By Telomerase R-HSA-171319 9.468630e-01 0.024 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.468630e-01 0.024 0 0
Insulin receptor recycling R-HSA-77387 9.468630e-01 0.024 0 0
Pyroptosis R-HSA-5620971 9.468630e-01 0.024 0 0
Dual incision in TC-NER R-HSA-6782135 9.472985e-01 0.024 0 0
Potential therapeutics for SARS R-HSA-9679191 9.500360e-01 0.022 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.508516e-01 0.022 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 9.508516e-01 0.022 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.508516e-01 0.022 0 0
Cellular response to chemical stress R-HSA-9711123 9.512402e-01 0.022 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 9.512660e-01 0.022 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.512660e-01 0.022 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 9.512660e-01 0.022 0 0
Catecholamine biosynthesis R-HSA-209905 9.512660e-01 0.022 0 0
Glycogen storage diseases R-HSA-3229121 9.512660e-01 0.022 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.512660e-01 0.022 0 0
Extension of Telomeres R-HSA-180786 9.516017e-01 0.022 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.519038e-01 0.021 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.519038e-01 0.021 0 0
Degradation of CDH1 R-HSA-9766229 9.525288e-01 0.021 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.525665e-01 0.021 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.525665e-01 0.021 0 0
Thyroxine biosynthesis R-HSA-209968 9.525665e-01 0.021 0 0
Regulation of gene expression in beta cells R-HSA-210745 9.525665e-01 0.021 0 0
Glucagon-type ligand receptors R-HSA-420092 9.525665e-01 0.021 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.532875e-01 0.021 0 0
Attenuation phase R-HSA-3371568 9.555732e-01 0.020 0 0
Generation of second messenger molecules R-HSA-202433 9.555732e-01 0.020 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.555732e-01 0.020 0 0
Diseases of Immune System R-HSA-5260271 9.555732e-01 0.020 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.564551e-01 0.019 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 9.565155e-01 0.019 0 0
PKR-mediated signaling R-HSA-9833482 9.565155e-01 0.019 0 0
PI3K Cascade R-HSA-109704 9.567227e-01 0.019 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.574188e-01 0.019 0 0
GAB1 signalosome R-HSA-180292 9.575238e-01 0.019 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.575238e-01 0.019 0 0
PKA activation R-HSA-163615 9.575238e-01 0.019 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.575238e-01 0.019 0 0
Platelet sensitization by LDL R-HSA-432142 9.575238e-01 0.019 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.576818e-01 0.019 0 0
Telomere Maintenance R-HSA-157579 9.594298e-01 0.018 0 0
Maturation of spike protein R-HSA-9694548 9.598674e-01 0.018 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.598674e-01 0.018 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.605720e-01 0.017 0 0
Trafficking of AMPA receptors R-HSA-399719 9.622659e-01 0.017 0 0
Cargo concentration in the ER R-HSA-5694530 9.622659e-01 0.017 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.622659e-01 0.017 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 9.623505e-01 0.017 0 0
Mitochondrial protein import R-HSA-1268020 9.626613e-01 0.017 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.626613e-01 0.017 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 9.629784e-01 0.016 0 0
Diseases of hemostasis R-HSA-9671793 9.629784e-01 0.016 0 0
The NLRP3 inflammasome R-HSA-844456 9.629784e-01 0.016 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.629784e-01 0.016 0 0
Translation of Structural Proteins R-HSA-9683701 9.637694e-01 0.016 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.641019e-01 0.016 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 9.662073e-01 0.015 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 9.662073e-01 0.015 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.663709e-01 0.015 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.677328e-01 0.014 0 0
Glycogen synthesis R-HSA-3322077 9.677328e-01 0.014 0 0
Pregnenolone biosynthesis R-HSA-196108 9.677328e-01 0.014 0 0
Protein hydroxylation R-HSA-9629569 9.677328e-01 0.014 0 0
Insulin receptor signalling cascade R-HSA-74751 9.686888e-01 0.014 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 9.700442e-01 0.013 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.705254e-01 0.013 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.706631e-01 0.013 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.706631e-01 0.013 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 9.713527e-01 0.013 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.718769e-01 0.012 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.718769e-01 0.012 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 9.718769e-01 0.012 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.718769e-01 0.012 0 0
Early Phase of HIV Life Cycle R-HSA-162594 9.718769e-01 0.012 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.728890e-01 0.012 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.730049e-01 0.012 0 0
Collagen formation R-HSA-1474290 9.731737e-01 0.012 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.733289e-01 0.012 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.733289e-01 0.012 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.733289e-01 0.012 0 0
Amine ligand-binding receptors R-HSA-375280 9.734381e-01 0.012 0 0
XBP1(S) activates chaperone genes R-HSA-381038 9.749899e-01 0.011 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.751672e-01 0.011 0 0
Translation of Structural Proteins R-HSA-9694635 9.752282e-01 0.011 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.754803e-01 0.011 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.754889e-01 0.011 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.754889e-01 0.011 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 9.754889e-01 0.011 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.754889e-01 0.011 0 0
Androgen biosynthesis R-HSA-193048 9.754889e-01 0.011 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.754889e-01 0.011 0 0
Response of endothelial cells to shear stress R-HSA-9860931 9.756332e-01 0.011 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.760763e-01 0.011 0 0
eNOS activation R-HSA-203615 9.762643e-01 0.010 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 9.762643e-01 0.010 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 9.762643e-01 0.010 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.762643e-01 0.010 0 0
Mitophagy R-HSA-5205647 9.762643e-01 0.010 0 0
Vesicle-mediated transport R-HSA-5653656 9.770341e-01 0.010 0 0
ABC transporter disorders R-HSA-5619084 9.772556e-01 0.010 0 0
Interleukin-10 signaling R-HSA-6783783 9.772556e-01 0.010 0 0
Regulation of CDH1 Function R-HSA-9764561 9.777411e-01 0.010 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.781345e-01 0.010 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.786373e-01 0.009 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 9.786373e-01 0.009 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.786373e-01 0.009 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.786373e-01 0.009 0 0
Reactions specific to the complex N-glycan synthesis pathway R-HSA-975578 9.786373e-01 0.009 0 0
Fructose metabolism R-HSA-5652084 9.786373e-01 0.009 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.786373e-01 0.009 0 0
Signaling by KIT in disease R-HSA-9669938 9.786373e-01 0.009 0 0
Cellular hexose transport R-HSA-189200 9.786373e-01 0.009 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.786373e-01 0.009 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 9.788859e-01 0.009 0 0
PERK regulates gene expression R-HSA-381042 9.788859e-01 0.009 0 0
Ribosome-associated quality control R-HSA-9948299 9.789047e-01 0.009 0 0
Glycosphingolipid transport R-HSA-9845576 9.812258e-01 0.008 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.812258e-01 0.008 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.813814e-01 0.008 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.813814e-01 0.008 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.813814e-01 0.008 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 9.813814e-01 0.008 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.815465e-01 0.008 0 0
Parasite infection R-HSA-9664407 9.815465e-01 0.008 0 0
Leishmania phagocytosis R-HSA-9664417 9.815465e-01 0.008 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.816191e-01 0.008 0 0
Triglyceride metabolism R-HSA-8979227 9.816864e-01 0.008 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.817171e-01 0.008 0 0
Signaling by FGFR R-HSA-190236 9.818562e-01 0.008 0 0
Neurotransmitter release cycle R-HSA-112310 9.819798e-01 0.008 0 0
Metal ion SLC transporters R-HSA-425410 9.825749e-01 0.008 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.827510e-01 0.008 0 0
NCAM1 interactions R-HSA-419037 9.833131e-01 0.007 0 0
Metabolism of folate and pterines R-HSA-196757 9.833131e-01 0.007 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.834015e-01 0.007 0 0
Metabolism of polyamines R-HSA-351202 9.834015e-01 0.007 0 0
Eukaryotic Translation Initiation R-HSA-72613 9.835654e-01 0.007 0 0
Cap-dependent Translation Initiation R-HSA-72737 9.835654e-01 0.007 0 0
Cytokine Signaling in Immune system R-HSA-1280215 9.837685e-01 0.007 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.837731e-01 0.007 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.837731e-01 0.007 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 9.837731e-01 0.007 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.837731e-01 0.007 0 0
Interleukin-6 family signaling R-HSA-6783589 9.837731e-01 0.007 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.843377e-01 0.007 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.847492e-01 0.007 0 0
IRE1alpha activates chaperones R-HSA-381070 9.847492e-01 0.007 0 0
PLC beta mediated events R-HSA-112043 9.849636e-01 0.007 0 0
Endogenous sterols R-HSA-211976 9.849636e-01 0.007 0 0
Biofilm formation R-HSA-9931953 9.851741e-01 0.006 0 0
HCMV Infection R-HSA-9609646 9.856331e-01 0.006 0 0
TCR signaling R-HSA-202403 9.857076e-01 0.006 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.858525e-01 0.006 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.858577e-01 0.006 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.858577e-01 0.006 0 0
G protein gated Potassium channels R-HSA-1296059 9.858577e-01 0.006 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.858577e-01 0.006 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.858577e-01 0.006 0 0
Fertilization R-HSA-1187000 9.858577e-01 0.006 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.858577e-01 0.006 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.859800e-01 0.006 0 0
Signaling by Insulin receptor R-HSA-74752 9.859800e-01 0.006 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.863854e-01 0.006 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.874421e-01 0.005 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.876747e-01 0.005 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.881466e-01 0.005 0 0
Interferon Signaling R-HSA-913531 9.881466e-01 0.005 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.883096e-01 0.005 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.888544e-01 0.005 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 9.892582e-01 0.005 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.892582e-01 0.005 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.892582e-01 0.005 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.892582e-01 0.005 0 0
Triglyceride biosynthesis R-HSA-75109 9.892582e-01 0.005 0 0
Insulin processing R-HSA-264876 9.892582e-01 0.005 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 9.895660e-01 0.005 0 0
Interleukin-12 signaling R-HSA-9020591 9.896022e-01 0.005 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.900327e-01 0.004 0 0
SLC transporter disorders R-HSA-5619102 9.900464e-01 0.004 0 0
MHC class II antigen presentation R-HSA-2132295 9.903346e-01 0.004 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.906384e-01 0.004 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.906384e-01 0.004 0 0
Iron assimilation using enterobactin R-HSA-9638334 9.906384e-01 0.004 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.906384e-01 0.004 0 0
Inflammasomes R-HSA-622312 9.906384e-01 0.004 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.907949e-01 0.004 0 0
Heme biosynthesis R-HSA-189451 9.907949e-01 0.004 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.907949e-01 0.004 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 9.908738e-01 0.004 0 0
Platelet homeostasis R-HSA-418346 9.912844e-01 0.004 0 0
Peptide chain elongation R-HSA-156902 9.913968e-01 0.004 0 0
G-protein mediated events R-HSA-112040 9.917725e-01 0.004 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.918357e-01 0.004 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.918357e-01 0.004 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.918357e-01 0.004 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.918414e-01 0.004 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.926687e-01 0.003 0 0
Downstream TCR signaling R-HSA-202424 9.928335e-01 0.003 0 0
Base Excision Repair R-HSA-73884 9.928335e-01 0.003 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.928898e-01 0.003 0 0
Neurotransmitter clearance R-HSA-112311 9.928898e-01 0.003 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.934634e-01 0.003 0 0
Platelet degranulation R-HSA-114608 9.934643e-01 0.003 0 0
ABC-family proteins mediated transport R-HSA-382556 9.935567e-01 0.003 0 0
Amyloid fiber formation R-HSA-977225 9.935644e-01 0.003 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.935836e-01 0.003 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.938035e-01 0.003 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.938035e-01 0.003 0 0
Selenocysteine synthesis R-HSA-2408557 9.941024e-01 0.003 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.943143e-01 0.002 0 0
Neddylation R-HSA-8951664 9.945140e-01 0.002 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.945438e-01 0.002 0 0
ECM proteoglycans R-HSA-3000178 9.945438e-01 0.002 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.945687e-01 0.002 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.947919e-01 0.002 0 0
SARS-CoV Infections R-HSA-9679506 9.949495e-01 0.002 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.952907e-01 0.002 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.952940e-01 0.002 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.952940e-01 0.002 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.952940e-01 0.002 0 0
Opioid Signalling R-HSA-111885 9.954882e-01 0.002 0 0
Synthesis of PC R-HSA-1483191 9.955393e-01 0.002 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.957675e-01 0.002 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.958989e-01 0.002 0 0
Developmental Cell Lineages R-HSA-9734767 9.959728e-01 0.002 0 0
Intraflagellar transport R-HSA-5620924 9.960505e-01 0.002 0 0
GPER1 signaling R-HSA-9634597 9.960505e-01 0.002 0 0
Ion channel transport R-HSA-983712 9.960539e-01 0.002 0 0
Formation of the cornified envelope R-HSA-6809371 9.960946e-01 0.002 0 0
Eukaryotic Translation Termination R-HSA-72764 9.962678e-01 0.002 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.962798e-01 0.002 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.964043e-01 0.002 0 0
Dual Incision in GG-NER R-HSA-5696400 9.964260e-01 0.002 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.964260e-01 0.002 0 0
Signal amplification R-HSA-392518 9.964260e-01 0.002 0 0
RA biosynthesis pathway R-HSA-5365859 9.964260e-01 0.002 0 0
Hyaluronan metabolism R-HSA-2142845 9.964260e-01 0.002 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.964260e-01 0.002 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.964260e-01 0.002 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.964651e-01 0.002 0 0
Gap junction trafficking and regulation R-HSA-157858 9.965041e-01 0.002 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.965041e-01 0.002 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.966052e-01 0.001 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.967683e-01 0.001 0 0
Interleukin-12 family signaling R-HSA-447115 9.967683e-01 0.001 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.968600e-01 0.001 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.968855e-01 0.001 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.968855e-01 0.001 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.968855e-01 0.001 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.971346e-01 0.001 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.971714e-01 0.001 0 0
HSF1 activation R-HSA-3371511 9.972859e-01 0.001 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.972859e-01 0.001 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.976079e-01 0.001 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.976348e-01 0.001 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.977832e-01 0.001 0 0
Nicotinate metabolism R-HSA-196807 9.978580e-01 0.001 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.978580e-01 0.001 0 0
Smooth Muscle Contraction R-HSA-445355 9.978591e-01 0.001 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 9.978976e-01 0.001 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.979183e-01 0.001 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.979389e-01 0.001 0 0
Elastic fibre formation R-HSA-1566948 9.979389e-01 0.001 0 0
Interferon gamma signaling R-HSA-877300 9.979527e-01 0.001 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 9.980884e-01 0.001 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.981451e-01 0.001 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.982039e-01 0.001 0 0
Pentose phosphate pathway R-HSA-71336 9.982039e-01 0.001 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.982039e-01 0.001 0 0
Protein folding R-HSA-391251 9.982348e-01 0.001 0 0
Viral mRNA Translation R-HSA-192823 9.982685e-01 0.001 0 0
G alpha (z) signalling events R-HSA-418597 9.983269e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.983454e-01 0.001 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.984060e-01 0.001 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.984349e-01 0.001 0 0
Glycogen metabolism R-HSA-8982491 9.984349e-01 0.001 0 0
N-glycan antennae elongation in the medial/trans-Golgi R-HSA-975576 9.984349e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.984788e-01 0.001 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.986361e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.986436e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.986936e-01 0.001 0 0
Intra-Golgi traffic R-HSA-6811438 9.988115e-01 0.001 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.988460e-01 0.001 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.989085e-01 0.000 0 0
GABA B receptor activation R-HSA-977444 9.989644e-01 0.000 0 0
Activation of GABAB receptors R-HSA-991365 9.989644e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.989807e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.990421e-01 0.000 0 0
GABA receptor activation R-HSA-977443 9.991000e-01 0.000 0 0
RAB geranylgeranylation R-HSA-8873719 9.991000e-01 0.000 0 0
tRNA Aminoacylation R-HSA-379724 9.991000e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.991000e-01 0.000 0 0
Gap junction trafficking R-HSA-190828 9.992136e-01 0.000 0 0
Surfactant metabolism R-HSA-5683826 9.992136e-01 0.000 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.992136e-01 0.000 0 0
ER-Phagosome pathway R-HSA-1236974 9.992826e-01 0.000 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.993148e-01 0.000 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.993148e-01 0.000 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.993262e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.993563e-01 0.000 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.993776e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.993809e-01 0.000 0 0
Integrin cell surface interactions R-HSA-216083 9.993965e-01 0.000 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.994029e-01 0.000 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.994029e-01 0.000 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.994029e-01 0.000 0 0
Ion transport by P-type ATPases R-HSA-936837 9.994537e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.994629e-01 0.000 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.994798e-01 0.000 0 0
Gluconeogenesis R-HSA-70263 9.995467e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.996050e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.996118e-01 0.000 0 0
Integration of energy metabolism R-HSA-163685 9.996226e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.996250e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.996250e-01 0.000 0 0
Azathioprine ADME R-HSA-9748787 9.996558e-01 0.000 0 0
Parasitic Infection Pathways R-HSA-9824443 9.996571e-01 0.000 0 0
Leishmania infection R-HSA-9658195 9.996571e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.996694e-01 0.000 0 0
rRNA processing R-HSA-72312 9.996847e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.997001e-01 0.000 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.997001e-01 0.000 0 0
The phototransduction cascade R-HSA-2514856 9.997001e-01 0.000 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.997387e-01 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 9.997723e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.997735e-01 0.000 0 0
Cardiac conduction R-HSA-5576891 9.997853e-01 0.000 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.997886e-01 0.000 0 0
Adaptive Immune System R-HSA-1280218 9.998189e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.998241e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.998272e-01 0.000 0 0
Protein ubiquitination R-HSA-8852135 9.998634e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.998634e-01 0.000 0 0
Synthesis of PA R-HSA-1483166 9.998688e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.998734e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.998738e-01 0.000 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.998843e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.998982e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.998989e-01 0.000 0 0
Peroxisomal protein import R-HSA-9033241 9.999004e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999067e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.999067e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999179e-01 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 9.999283e-01 0.000 0 0
Protein localization R-HSA-9609507 9.999346e-01 0.000 0 0
Glycosphingolipid biosynthesis R-HSA-9840309 9.999500e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.999500e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.999501e-01 0.000 0 0
Hemostasis R-HSA-109582 9.999574e-01 0.000 0 0
Regulation of insulin secretion R-HSA-422356 9.999608e-01 0.000 0 0
Neuronal System R-HSA-112316 9.999650e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999653e-01 0.000 0 0
Transmission across Chemical Synapses R-HSA-112315 9.999682e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999771e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.999810e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999810e-01 0.000 0 0
Muscle contraction R-HSA-397014 9.999829e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999830e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.999834e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999834e-01 0.000 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.999880e-01 0.000 0 0
Viral Infection Pathways R-HSA-9824446 9.999901e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.999907e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999920e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999952e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999966e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999968e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999979e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.999979e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999984e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999987e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999989e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999990e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999991e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999992e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999996e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999996e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999996e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999996e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999997e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999997e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999998e-01 0.000 0 0
Neutrophil degranulation R-HSA-6798695 9.999998e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999999e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999999e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999999e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999999e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
G alpha (q) signalling events R-HSA-416476 1.000000e+00 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Translation R-HSA-72766 1.000000e+00 0.000 0 0
Visual phototransduction R-HSA-2187338 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 1.000000e+00 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Immune System R-HSA-168256 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
G alpha (i) signalling events R-HSA-418594 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Innate Immune System R-HSA-168249 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 0.000002 5.724 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 0.000002 5.765 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 0.000002 5.618 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 0.000004 5.377 0 0
Nuclear Envelope Breakdown R-HSA-2980766 0.000005 5.281 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 0.000009 5.044 0 0
Epigenetic regulation of gene expression R-HSA-212165 0.000009 5.048 0 0
Chromatin organization R-HSA-4839726 0.000011 4.974 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 0.000012 4.936 0 0
Cell Cycle R-HSA-1640170 0.000012 4.908 1 0
Signaling by Hippo R-HSA-2028269 0.000013 4.875 0 0
Cell Cycle, Mitotic R-HSA-69278 0.000016 4.783 1 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 0.000020 4.688 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 0.000022 4.648 0 0
Activation of BH3-only proteins R-HSA-114452 0.000022 4.648 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 0.000029 4.541 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 0.000029 4.541 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 0.000033 4.486 0 0
Signal Transduction R-HSA-162582 0.000035 4.459 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 0.000036 4.438 0 0
Apoptosis R-HSA-109581 0.000039 4.410 0 0
Chromatin modifying enzymes R-HSA-3247509 0.000040 4.394 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 0.000042 4.377 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 0.000043 4.362 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 0.000046 4.338 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 0.000057 4.241 0 0
Nuclear import of Rev protein R-HSA-180746 0.000071 4.148 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 0.000088 4.056 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 0.000116 3.937 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 0.000116 3.937 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 0.000131 3.882 0 0
Regulation of PTEN gene transcription R-HSA-8943724 0.000130 3.887 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 0.000159 3.799 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 0.000191 3.718 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 0.000226 3.645 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 0.000214 3.669 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 0.000229 3.639 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 0.000229 3.639 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 0.000226 3.645 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 0.000274 3.563 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 0.000286 3.543 0 0
M Phase R-HSA-68886 0.000326 3.487 0 0
Membrane Trafficking R-HSA-199991 0.000359 3.445 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 0.000381 3.419 0 0
Mitotic Prophase R-HSA-68875 0.000396 3.402 0 0
Cellular response to heat stress R-HSA-3371556 0.000434 3.363 0 0
mTORC1-mediated signalling R-HSA-166208 0.000447 3.349 0 0
Viral Messenger RNA Synthesis R-HSA-168325 0.000509 3.294 0 0
MITF-M-dependent gene expression R-HSA-9856651 0.000497 3.303 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 0.000544 3.264 0 0
Programmed Cell Death R-HSA-5357801 0.000576 3.239 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 0.000618 3.209 0 0
Gene expression (Transcription) R-HSA-74160 0.000640 3.194 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 0.000633 3.198 0 0
Apoptotic execution phase R-HSA-75153 0.000718 3.144 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 0.000718 3.144 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 0.000859 3.066 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 0.000859 3.066 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 0.000856 3.068 0 0
ISG15 antiviral mechanism R-HSA-1169408 0.000912 3.040 0 0
Regulation of endogenous retroelements R-HSA-9842860 0.000958 3.019 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 0.001050 2.979 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 0.001050 2.979 0 0
Inositol phosphate metabolism R-HSA-1483249 0.001026 2.989 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 0.001086 2.964 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 0.001125 2.949 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 0.001420 2.848 0 0
MTOR signalling R-HSA-165159 0.001408 2.851 0 0
Cell-extracellular matrix interactions R-HSA-446353 0.001379 2.860 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 0.001471 2.832 0 0
Clathrin-mediated endocytosis R-HSA-8856828 0.001529 2.816 0 0
tRNA processing in the nucleus R-HSA-6784531 0.001801 2.745 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 0.002062 2.686 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 0.002417 2.617 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 0.002444 2.612 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 0.002444 2.612 0 0
Signaling downstream of RAS mutants R-HSA-9649948 0.002444 2.612 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 0.002525 2.598 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 0.002618 2.582 0 0
Signaling by RAS mutants R-HSA-6802949 0.002444 2.612 0 0
Adipogenesis R-HSA-9843745 0.002751 2.561 0 0
Diseases of mitotic cell cycle R-HSA-9675126 0.003014 2.521 0 0
Late Phase of HIV Life Cycle R-HSA-162599 0.003134 2.504 0 0
PKMTs methylate histone lysines R-HSA-3214841 0.003638 2.439 0 0
Metabolism of non-coding RNA R-HSA-194441 0.003773 2.423 0 0
snRNP Assembly R-HSA-191859 0.003773 2.423 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 0.003801 2.420 0 0
HIV Life Cycle R-HSA-162587 0.003976 2.401 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 0.004012 2.397 0 0
Signaling by RAF1 mutants R-HSA-9656223 0.004151 2.382 0 0
MAP2K and MAPK activation R-HSA-5674135 0.004151 2.382 0 0
Cellular Senescence R-HSA-2559583 0.004161 2.381 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 0.004597 2.338 0 0
Mitotic Anaphase R-HSA-68882 0.004473 2.349 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 0.004716 2.326 0 0
mRNA 3'-end processing R-HSA-72187 0.005061 2.296 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 0.005154 2.288 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 0.005302 2.276 0 0
Formation of annular gap junctions R-HSA-196025 0.005302 2.276 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 0.005302 2.276 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 0.005663 2.247 0 0
Oncogenic MAPK signaling R-HSA-6802957 0.006509 2.186 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 0.006754 2.170 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 0.006801 2.167 0 0
Diseases of Telomere Maintenance R-HSA-9673013 0.007124 2.147 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 0.007124 2.147 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 0.007124 2.147 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 0.007124 2.147 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 0.007124 2.147 0 0
Gap junction degradation R-HSA-190873 0.007155 2.145 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 0.007155 2.145 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 0.007688 2.114 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 0.007519 2.124 0 0
Cell junction organization R-HSA-446728 0.008163 2.088 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 0.007519 2.124 0 0
Recycling pathway of L1 R-HSA-437239 0.008509 2.070 0 0
Mitotic Prometaphase R-HSA-68877 0.008522 2.069 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 0.008836 2.054 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 0.008849 2.053 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 0.009088 2.042 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 0.009492 2.023 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 0.009950 2.002 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 0.009950 2.002 0 0
Cell Cycle Checkpoints R-HSA-69620 0.010274 1.988 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 0.010453 1.981 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 0.010649 1.973 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 0.010649 1.973 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 0.011034 1.957 0 0
Deadenylation of mRNA R-HSA-429947 0.012135 1.916 0 0
Nuclear RNA decay R-HSA-9930044 0.012143 1.916 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 0.012143 1.916 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 0.012596 1.900 0 0
Cell-Cell communication R-HSA-1500931 0.013455 1.871 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 0.013784 1.861 0 0
Activation of RAC1 R-HSA-428540 0.015120 1.820 0 0
RAF activation R-HSA-5673000 0.015533 1.809 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 0.015120 1.820 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 0.015120 1.820 0 0
Breakdown of the nuclear lamina R-HSA-352238 0.015388 1.813 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 0.014193 1.848 0 0
TGFBR3 expression R-HSA-9839394 0.014039 1.853 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 0.015443 1.811 0 0
SARS-CoV-2-host interactions R-HSA-9705683 0.014541 1.837 0 0
Amplification of signal from the kinetochores R-HSA-141424 0.016604 1.780 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 0.016604 1.780 0 0
UCH proteinases R-HSA-5689603 0.018016 1.744 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 0.018658 1.729 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 0.018658 1.729 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 0.018681 1.729 0 0
Metabolism of RNA R-HSA-8953854 0.018809 1.726 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 0.019314 1.714 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 0.019386 1.713 0 0
Rab regulation of trafficking R-HSA-9007101 0.019519 1.710 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 0.019631 1.707 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 0.022670 1.645 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 0.022670 1.645 0 0
Mitotic Spindle Checkpoint R-HSA-69618 0.024195 1.616 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 0.024583 1.609 0 0
Regulation of CDH1 Function R-HSA-9764561 0.022472 1.648 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 0.024221 1.616 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 0.024570 1.610 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 0.025014 1.602 0 0
SOS-mediated signalling R-HSA-112412 0.025325 1.596 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 0.025325 1.596 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 0.025325 1.596 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 0.025464 1.594 0 0
Deubiquitination R-HSA-5688426 0.025920 1.586 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 0.026267 1.581 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 0.026712 1.573 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 0.026843 1.571 0 0
Signaling by PDGFR in disease R-HSA-9671555 0.028244 1.549 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 0.028535 1.545 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 0.028535 1.545 0 0
mRNA Splicing - Major Pathway R-HSA-72163 0.028908 1.539 0 0
Type I hemidesmosome assembly R-HSA-446107 0.032226 1.492 0 0
Nucleotide Excision Repair R-HSA-5696398 0.034602 1.461 0 0
HCMV Early Events R-HSA-9609690 0.031449 1.502 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 0.031851 1.497 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 0.032226 1.492 0 0
Neurexins and neuroligins R-HSA-6794361 0.036530 1.437 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 0.032623 1.486 0 0
S Phase R-HSA-69242 0.034150 1.467 0 0
Vesicle-mediated transport R-HSA-5653656 0.035859 1.445 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 0.031449 1.502 0 0
G2/M Checkpoints R-HSA-69481 0.035718 1.447 0 0
G2/M DNA damage checkpoint R-HSA-69473 0.035306 1.452 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 0.032226 1.492 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 0.032936 1.482 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 0.037113 1.430 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 0.037656 1.424 0 0
PTEN Regulation R-HSA-6807070 0.038534 1.414 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 0.039416 1.404 0 0
Separation of Sister Chromatids R-HSA-2467813 0.039701 1.401 0 0
HIV Infection R-HSA-162906 0.039711 1.401 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 0.040006 1.398 0 0
Unwinding of DNA R-HSA-176974 0.040006 1.398 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 0.041274 1.384 0 0
TBC/RABGAPs R-HSA-8854214 0.042758 1.369 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 0.043116 1.365 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 0.043657 1.360 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 0.043657 1.360 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 0.043657 1.360 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 0.043657 1.360 0 0
Death Receptor Signaling R-HSA-73887 0.044838 1.348 0 0
mRNA Splicing R-HSA-72172 0.044990 1.347 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 0.054522 1.263 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 0.054522 1.263 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 0.048643 1.313 0 0
FOXO-mediated transcription R-HSA-9614085 0.046056 1.337 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 0.046852 1.329 0 0
Signal attenuation R-HSA-74749 0.048643 1.313 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 0.051409 1.289 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 0.048643 1.313 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 0.051682 1.287 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 0.048643 1.313 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 0.054137 1.267 0 0
Adherens junctions interactions R-HSA-418990 0.046362 1.334 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 0.051682 1.287 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 0.046056 1.337 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 0.053465 1.272 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 0.050532 1.296 0 0
Signaling by Leptin R-HSA-2586552 0.048643 1.313 0 0
NRAGE signals death through JNK R-HSA-193648 0.049738 1.303 0 0
Glycolysis R-HSA-70171 0.048651 1.313 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 0.055262 1.258 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 0.057171 1.243 0 0
Regulation of TP53 Activity R-HSA-5633007 0.057722 1.239 0 0
Signaling by NTRKs R-HSA-166520 0.060151 1.221 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 0.060330 1.219 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 0.060330 1.219 0 0
HIV elongation arrest and recovery R-HSA-167287 0.063488 1.197 0 0
Pausing and recovery of HIV elongation R-HSA-167290 0.063488 1.197 0 0
NGF-stimulated transcription R-HSA-9031628 0.063771 1.195 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 0.064325 1.192 0 0
Rap1 signalling R-HSA-392517 0.064675 1.189 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 0.065700 1.182 0 0
RNA Polymerase II Transcription R-HSA-73857 0.067049 1.174 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 0.068377 1.165 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 0.068377 1.165 0 0
Protein-protein interactions at synapses R-HSA-6794362 0.069461 1.158 0 0
SARS-CoV-1-host interactions R-HSA-9692914 0.069632 1.157 0 0
Mitochondrial biogenesis R-HSA-1592230 0.070547 1.152 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 0.071301 1.147 0 0
IRS activation R-HSA-74713 0.071301 1.147 0 0
G2 Phase R-HSA-68911 0.071301 1.147 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 0.071301 1.147 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 0.072666 1.139 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 0.079401 1.100 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 0.079401 1.100 0 0
Activation of the pre-replicative complex R-HSA-68962 0.076682 1.115 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 0.084408 1.074 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 0.090099 1.045 0 0
G0 and Early G1 R-HSA-1538133 0.091236 1.040 1 1
DNA strand elongation R-HSA-69190 0.091236 1.040 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 0.074472 1.128 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 0.089498 1.048 0 0
Frs2-mediated activation R-HSA-170968 0.091141 1.040 0 0
HATs acetylate histones R-HSA-3214847 0.087147 1.060 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 0.076213 1.118 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 0.076213 1.118 0 0
Signaling by LTK R-HSA-9842663 0.079401 1.100 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 0.091141 1.040 0 0
Negative regulation of MAPK pathway R-HSA-5675221 0.088629 1.052 0 0
Cell-cell junction organization R-HSA-421270 0.087649 1.057 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 0.089498 1.048 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 0.073043 1.136 0 0
Heme signaling R-HSA-9707616 0.074744 1.126 0 0
Signaling by ALK in cancer R-HSA-9700206 0.073043 1.136 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 0.076682 1.115 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 0.091141 1.040 0 0
Gene Silencing by RNA R-HSA-211000 0.073043 1.136 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 0.093468 1.029 1 0
RNA Polymerase I Transcription Initiation R-HSA-73762 0.095226 1.021 0 0
Host Interactions of HIV factors R-HSA-162909 0.095347 1.021 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 0.099447 1.002 0 0
Estrogen-dependent gene expression R-HSA-9018519 0.102091 0.991 0 0
HDACs deacetylate histones R-HSA-3214815 0.102112 0.991 0 0
Signaling by VEGF R-HSA-194138 0.103304 0.986 0 0
Retrograde neurotrophin signalling R-HSA-177504 0.103552 0.985 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 0.106146 0.974 0 0
Striated Muscle Contraction R-HSA-390522 0.107105 0.970 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 0.108429 0.965 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 0.109260 0.962 0 0
Erythropoietin activates RAS R-HSA-9027284 0.116586 0.933 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 0.116586 0.933 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 0.116586 0.933 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 0.116586 0.933 0 0
DCC mediated attractive signaling R-HSA-418885 0.116586 0.933 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 0.117023 0.932 0 0
TICAM1 deficiency - HSE R-HSA-5602566 0.117023 0.932 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 0.119488 0.923 0 0
Neurodegenerative Diseases R-HSA-8863678 0.119488 0.923 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 0.119488 0.923 0 0
Glucose metabolism R-HSA-70326 0.122274 0.913 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 0.124124 0.906 0 0
Signaling by TGFBR3 R-HSA-9839373 0.124124 0.906 0 0
Oncogene Induced Senescence R-HSA-2559585 0.124224 0.906 0 0
HCMV Infection R-HSA-9609646 0.125737 0.901 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 0.128212 0.892 0 0
TRAF3 deficiency - HSE R-HSA-5602571 0.170300 0.769 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 0.170300 0.769 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 0.170300 0.769 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 0.220364 0.657 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 0.220364 0.657 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 0.220364 0.657 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 0.220364 0.657 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 0.129240 0.889 0 0
TRIF-mediated programmed cell death R-HSA-2562578 0.129240 0.889 0 0
Recycling of eIF2:GDP R-HSA-72731 0.129240 0.889 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 0.267411 0.573 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 0.267411 0.573 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 0.267411 0.573 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 0.267411 0.573 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 0.172154 0.764 0 0
Lipophagy R-HSA-9613354 0.172154 0.764 0 0
HCN channels R-HSA-1296061 0.311621 0.506 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 0.311621 0.506 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 0.311621 0.506 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 0.311621 0.506 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 0.311621 0.506 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 0.311621 0.506 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 0.311621 0.506 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 0.311621 0.506 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 0.311621 0.506 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 0.194389 0.711 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 0.130196 0.885 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 0.216956 0.664 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 0.353166 0.452 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 0.189400 0.723 0 0
Repression of WNT target genes R-HSA-4641265 0.262618 0.581 0 0
Polymerase switching R-HSA-69091 0.262618 0.581 0 0
Leading Strand Synthesis R-HSA-69109 0.262618 0.581 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 0.392206 0.406 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 0.392206 0.406 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 0.392206 0.406 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 0.392206 0.406 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 0.392206 0.406 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 0.392206 0.406 0 0
Phosphorylation of Emi1 R-HSA-176417 0.392206 0.406 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 0.392206 0.406 0 0
Signaling by RNF43 mutants R-HSA-5340588 0.392206 0.406 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 0.392206 0.406 0 0
Interaction between L1 and Ankyrins R-HSA-445095 0.152460 0.817 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 0.152460 0.817 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 0.152460 0.817 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 0.205148 0.688 0 0
Formation of axial mesoderm R-HSA-9796292 0.285510 0.544 0 0
G1/S-Specific Transcription R-HSA-69205 0.133229 0.875 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 0.176136 0.754 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 0.308326 0.511 0 0
Removal of the Flap Intermediate R-HSA-69166 0.308326 0.511 0 0
Signaling by LTK in cancer R-HSA-9842640 0.428892 0.368 0 0
Erythropoietin activates STAT5 R-HSA-9027283 0.428892 0.368 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 0.171964 0.765 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 0.330992 0.480 0 0
Interleukin receptor SHC signaling R-HSA-912526 0.270539 0.568 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 0.270539 0.568 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 0.270539 0.568 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 0.287274 0.542 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 0.353444 0.452 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 0.353444 0.452 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 0.463365 0.334 0 0
IFNG signaling activates MAPKs R-HSA-9732724 0.463365 0.334 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 0.463365 0.334 0 0
Disinhibition of SNARE formation R-HSA-114516 0.463365 0.334 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 0.463365 0.334 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 0.463365 0.334 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 0.158145 0.801 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 0.158145 0.801 0 0
AURKA Activation by TPX2 R-HSA-8854518 0.182155 0.740 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 0.320934 0.494 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 0.397484 0.401 0 0
RSK activation R-HSA-444257 0.495760 0.305 0 0
Regulation by c-FLIP R-HSA-3371378 0.495760 0.305 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 0.495760 0.305 0 0
Dimerization of procaspase-8 R-HSA-69416 0.495760 0.305 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 0.495760 0.305 0 0
MET receptor recycling R-HSA-8875656 0.495760 0.305 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 0.354620 0.450 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 0.354620 0.450 0 0
Formation of the Early Elongation Complex R-HSA-113418 0.354620 0.450 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 0.243357 0.614 0 0
Signaling by Erythropoietin R-HSA-9006335 0.371394 0.430 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 0.335844 0.474 0 0
HSF1-dependent transactivation R-HSA-3371571 0.307118 0.513 0 0
Centrosome maturation R-HSA-380287 0.261937 0.582 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 0.260555 0.584 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 0.331243 0.480 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 0.363761 0.439 0 0
HIV Transcription Initiation R-HSA-167161 0.363761 0.439 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 0.363761 0.439 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 0.391625 0.407 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 0.392063 0.407 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 0.419305 0.377 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 0.500715 0.300 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 0.469430 0.328 0 0
Dual Incision in GG-NER R-HSA-5696400 0.469430 0.328 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 0.469430 0.328 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 0.412975 0.384 0 0
Transcription of the HIV genome R-HSA-167172 0.198954 0.701 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 0.234693 0.629 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 0.473638 0.325 0 0
HIV Transcription Elongation R-HSA-167169 0.335844 0.474 0 0
mRNA Capping R-HSA-72086 0.371394 0.430 0 0
Lagging Strand Synthesis R-HSA-69186 0.480971 0.318 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 0.169018 0.772 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 0.169018 0.772 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 0.169123 0.772 0 0
G1 Phase R-HSA-69236 0.225546 0.647 0 0
Cyclin D associated events in G1 R-HSA-69231 0.225546 0.647 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 0.169018 0.772 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 0.253299 0.596 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 0.234229 0.630 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 0.335844 0.474 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 0.173983 0.759 0 0
Processive synthesis on the lagging strand R-HSA-69183 0.330992 0.480 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 0.388084 0.411 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 0.358290 0.446 0 0
Circadian clock R-HSA-9909396 0.318645 0.497 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 0.144332 0.841 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 0.237452 0.624 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 0.129240 0.889 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 0.150387 0.823 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 0.194389 0.711 0 0
PI3K/AKT activation R-HSA-198203 0.194389 0.711 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 0.321912 0.492 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 0.335844 0.474 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 0.460753 0.337 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 0.280451 0.552 0 0
RNA Polymerase III Transcription R-HSA-74158 0.280451 0.552 0 0
Regulation of gap junction activity R-HSA-191650 0.311621 0.506 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 0.353166 0.452 0 0
NF-kB is activated and signals survival R-HSA-209560 0.239735 0.620 0 0
E2F mediated regulation of DNA replication R-HSA-113510 0.189400 0.723 0 0
VLDLR internalisation and degradation R-HSA-8866427 0.262618 0.581 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 0.463365 0.334 0 0
Trafficking of AMPA receptors R-HSA-399719 0.404664 0.393 0 0
Synthesis of DNA R-HSA-69239 0.324688 0.489 0 0
Ephrin signaling R-HSA-3928664 0.418982 0.378 0 0
G1/S Transition R-HSA-69206 0.259748 0.585 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 0.331932 0.479 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 0.331243 0.480 0 0
MET activates RAS signaling R-HSA-8851805 0.262618 0.581 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 0.488458 0.311 0 0
Calcineurin activates NFAT R-HSA-2025928 0.172154 0.764 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 0.353166 0.452 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 0.308326 0.511 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 0.463365 0.334 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 0.418982 0.378 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 0.219167 0.659 0 0
Post NMDA receptor activation events R-HSA-438064 0.251964 0.599 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 0.388084 0.411 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 0.480971 0.318 0 0
RNA Polymerase I Transcription R-HSA-73864 0.290506 0.537 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 0.174882 0.757 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 0.203518 0.691 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 0.285510 0.544 0 0
MyD88-independent TLR4 cascade R-HSA-166166 0.489031 0.311 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 0.141108 0.850 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 0.443120 0.353 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 0.489031 0.311 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 0.340812 0.467 0 0
FasL/ CD95L signaling R-HSA-75157 0.267411 0.573 0 0
Polo-like kinase mediated events R-HSA-156711 0.173983 0.759 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 0.308326 0.511 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 0.253919 0.595 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 0.353444 0.452 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 0.463365 0.334 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 0.397484 0.401 0 0
Switching of origins to a post-replicative state R-HSA-69052 0.243357 0.614 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 0.423881 0.373 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 0.239735 0.620 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 0.173983 0.759 0 0
DNA Replication Pre-Initiation R-HSA-69002 0.479920 0.319 0 0
GP1b-IX-V activation signalling R-HSA-430116 0.172154 0.764 0 0
p75NTR signals via NF-kB R-HSA-193639 0.330992 0.480 0 0
Prolonged ERK activation events R-HSA-169893 0.130196 0.885 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 0.274559 0.561 0 0
Regulation of cortical dendrite branching R-HSA-8985801 0.220364 0.657 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 0.267411 0.573 0 0
MET interacts with TNS proteins R-HSA-8875513 0.267411 0.573 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 0.172154 0.764 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 0.311621 0.506 0 0
Disorders of Developmental Biology R-HSA-9675151 0.144332 0.841 0 0
Reelin signalling pathway R-HSA-8866376 0.353166 0.452 0 0
TRAIL signaling R-HSA-75158 0.392206 0.406 0 0
Synthesis of PS R-HSA-1483101 0.392206 0.406 0 0
G2/M DNA replication checkpoint R-HSA-69478 0.428892 0.368 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 0.171964 0.765 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 0.287274 0.542 0 0
Adrenoceptors R-HSA-390696 0.495760 0.305 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 0.495760 0.305 0 0
MAP kinase activation R-HSA-450294 0.262003 0.582 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 0.418982 0.378 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 0.418982 0.378 0 0
Orc1 removal from chromatin R-HSA-68949 0.319154 0.496 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 0.440082 0.356 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 0.453513 0.343 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 0.500715 0.300 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 0.456397 0.341 0 0
Signaling by WNT R-HSA-195721 0.261545 0.582 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 0.349800 0.456 0 0
TCF dependent signaling in response to WNT R-HSA-201681 0.133723 0.874 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 0.136961 0.863 0 0
Chaperone Mediated Autophagy R-HSA-9613829 0.418982 0.378 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 0.184948 0.733 0 0
Aggrephagy R-HSA-9646399 0.335844 0.474 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 0.500715 0.300 0 0
Interleukin-17 signaling R-HSA-448424 0.358290 0.446 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 0.330992 0.480 0 0
RAF/MAP kinase cascade R-HSA-5673001 0.371955 0.430 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 0.375624 0.425 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 0.440082 0.356 0 0
Differentiation of T cells R-HSA-9945266 0.353444 0.452 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 0.353444 0.452 0 0
Calmodulin induced events R-HSA-111933 0.280451 0.552 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 0.353166 0.452 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 0.375624 0.425 0 0
Coenzyme A biosynthesis R-HSA-196783 0.375624 0.425 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 0.495760 0.305 0 0
HCMV Late Events R-HSA-9610379 0.298590 0.525 0 0
CaM pathway R-HSA-111997 0.280451 0.552 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 0.218581 0.660 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 0.470768 0.327 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 0.410691 0.386 0 0
Formation of paraxial mesoderm R-HSA-9793380 0.428424 0.368 0 0
EGFR downregulation R-HSA-182971 0.404664 0.393 0 0
Signalling to ERKs R-HSA-187687 0.266812 0.574 0 0
PLC beta mediated events R-HSA-112043 0.428424 0.368 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 0.311621 0.506 0 0
Pervasive developmental disorders R-HSA-9005895 0.262618 0.581 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 0.262618 0.581 0 0
Disorders of Nervous System Development R-HSA-9697154 0.262618 0.581 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 0.463365 0.334 0 0
Mitotic G2-G2/M phases R-HSA-453274 0.154620 0.811 0 0
DAG and IP3 signaling R-HSA-1489509 0.236815 0.626 0 0
Selective autophagy R-HSA-9663891 0.155857 0.807 0 0
Assembly of the pre-replicative complex R-HSA-68867 0.459324 0.338 0 0
G2/M Transition R-HSA-69275 0.299412 0.524 0 0
Organelle biogenesis and maintenance R-HSA-1852241 0.294351 0.531 0 0
Signaling by FGFR1 in disease R-HSA-5655302 0.363761 0.439 0 0
Cellular responses to stress R-HSA-2262752 0.262748 0.580 0 0
Ca-dependent events R-HSA-111996 0.377708 0.423 0 0
Macroautophagy R-HSA-1632852 0.395779 0.403 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 0.437400 0.359 0 0
HDMs demethylate histones R-HSA-3214842 0.304084 0.517 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 0.380161 0.420 0 0
MHC class II antigen presentation R-HSA-2132295 0.480603 0.318 0 0
RUNX2 regulates bone development R-HSA-8941326 0.500615 0.300 0 0
Generic Transcription Pathway R-HSA-212436 0.238315 0.623 0 0
Signaling by EGFR R-HSA-177929 0.211803 0.674 0 0
ARMS-mediated activation R-HSA-170984 0.172154 0.764 0 0
NADE modulates death signalling R-HSA-205025 0.311621 0.506 0 0
Sensory perception of sour taste R-HSA-9729555 0.311621 0.506 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 0.392206 0.406 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 0.308326 0.511 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 0.270539 0.568 0 0
Activation of ATR in response to replication stress R-HSA-176187 0.226741 0.644 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 0.130558 0.884 0 0
VLDL clearance R-HSA-8964046 0.463365 0.334 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 0.337790 0.471 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 0.404664 0.393 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 0.437400 0.359 0 0
Effects of PIP2 hydrolysis R-HSA-114508 0.453513 0.343 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 0.479920 0.319 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 0.429489 0.367 0 0
FGFR1 mutant receptor activation R-HSA-1839124 0.437400 0.359 0 0
MAPK family signaling cascades R-HSA-5683057 0.514931 0.288 0 0
G-protein mediated events R-HSA-112040 0.499532 0.301 0 0
Signaling by MET R-HSA-6806834 0.309932 0.509 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 0.371394 0.430 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 0.159499 0.797 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 0.402509 0.395 0 0
Gap junction trafficking and regulation R-HSA-157858 0.283266 0.548 0 0
Myogenesis R-HSA-525793 0.141108 0.850 0 0
Ovarian tumor domain proteases R-HSA-5689896 0.142518 0.846 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 0.308326 0.511 0 0
ERK/MAPK targets R-HSA-198753 0.480971 0.318 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 0.410789 0.386 0 0
Developmental Biology R-HSA-1266738 0.310099 0.508 0 0
L1CAM interactions R-HSA-373760 0.192276 0.716 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 0.173983 0.759 0 0
Mitophagy R-HSA-5205647 0.469430 0.328 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 0.349977 0.456 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 0.226741 0.644 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 0.129240 0.889 0 0
The NLRP1 inflammasome R-HSA-844455 0.267411 0.573 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 0.172154 0.764 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 0.130196 0.885 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 0.392206 0.406 0 0
CREB phosphorylation R-HSA-199920 0.428892 0.368 0 0
NADPH regeneration R-HSA-389542 0.428892 0.368 0 0
Regulation of PTEN localization R-HSA-8948747 0.463365 0.334 0 0
FLT3 signaling in disease R-HSA-9682385 0.280451 0.552 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 0.495760 0.305 0 0
Sodium/Proton exchangers R-HSA-425986 0.495760 0.305 0 0
Downstream signal transduction R-HSA-186763 0.404664 0.393 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 0.337790 0.471 0 0
Signaling by ALK R-HSA-201556 0.161897 0.791 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 0.221180 0.655 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 0.179828 0.745 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 0.162453 0.789 0 0
Sensory processing of sound R-HSA-9659379 0.179449 0.746 0 0
Nephrin family interactions R-HSA-373753 0.460753 0.337 0 0
Intracellular signaling by second messengers R-HSA-9006925 0.195597 0.709 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 0.262618 0.581 0 0
EPH-Ephrin signaling R-HSA-2682334 0.449411 0.347 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 0.440457 0.356 0 0
Gastrulation R-HSA-9758941 0.466069 0.332 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 0.234229 0.630 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 0.500715 0.300 0 0
DNA Damage Bypass R-HSA-73893 0.473638 0.325 0 0
Interleukin-2 family signaling R-HSA-451927 0.335844 0.474 0 0
Signaling by FGFR in disease R-HSA-1226099 0.402047 0.396 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 0.150387 0.823 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 0.392206 0.406 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 0.221180 0.655 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 0.216330 0.665 0 0
Signaling by NOTCH4 R-HSA-9013694 0.252596 0.598 0 0
Gap junction trafficking R-HSA-190828 0.405496 0.392 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 0.367710 0.434 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 0.429489 0.367 0 0
Diseases of programmed cell death R-HSA-9645723 0.260555 0.584 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 0.140007 0.854 0 0
RMTs methylate histone arginines R-HSA-3214858 0.225546 0.647 0 0
Netrin-1 signaling R-HSA-373752 0.405496 0.392 0 0
PIP3 activates AKT signaling R-HSA-1257604 0.321751 0.492 0 0
Josephin domain DUBs R-HSA-5689877 0.194389 0.711 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 0.152460 0.817 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 0.353444 0.452 0 0
Glycosphingolipid transport R-HSA-9845576 0.500615 0.300 0 0
TNF signaling R-HSA-75893 0.367710 0.434 0 0
ChREBP activates metabolic gene expression R-HSA-163765 0.216956 0.664 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 0.349800 0.456 0 0
Formation of definitive endoderm R-HSA-9823730 0.460753 0.337 0 0
Influenza Infection R-HSA-168255 0.256719 0.591 0 0
Uptake and function of anthrax toxins R-HSA-5210891 0.397484 0.401 0 0
Regulation of TNFR1 signaling R-HSA-5357905 0.433037 0.363 0 0
Signaling by NOTCH3 R-HSA-9012852 0.355534 0.449 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 0.463365 0.334 0 0
RET signaling R-HSA-8853659 0.280451 0.552 0 0
tRNA processing R-HSA-72306 0.205593 0.687 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 0.353444 0.452 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 0.446679 0.350 0 0
Specification of primordial germ cells R-HSA-9827857 0.397484 0.401 0 0
SARS-CoV-2 Infection R-HSA-9694516 0.167912 0.775 0 0
Interleukin-7 signaling R-HSA-1266695 0.304084 0.517 0 0
SARS-CoV Infections R-HSA-9679506 0.211102 0.676 0 0
Growth hormone receptor signaling R-HSA-982772 0.270539 0.568 0 0
G alpha (12/13) signalling events R-HSA-416482 0.172018 0.764 0 0
SARS-CoV-1 Infection R-HSA-9678108 0.432264 0.364 0 0
SLC transporter disorders R-HSA-5619102 0.368035 0.434 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 0.515852 0.287 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 0.515852 0.287 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 0.516087 0.287 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 0.517806 0.286 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 0.517806 0.286 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 0.517806 0.286 0 0
Autophagy R-HSA-9612973 0.519855 0.284 0 0
FGFR2 alternative splicing R-HSA-6803529 0.519968 0.284 0 0
Notch-HLH transcription pathway R-HSA-350054 0.519968 0.284 0 0
LDL clearance R-HSA-8964038 0.519968 0.284 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 0.519968 0.284 0 0
Cellular response to chemical stress R-HSA-9711123 0.524690 0.280 0 0
Meiotic synapsis R-HSA-1221632 0.525942 0.279 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 0.525942 0.279 0 0
Interleukin-21 signaling R-HSA-9020958 0.526201 0.279 0 0
CASP8 activity is inhibited R-HSA-5218900 0.526201 0.279 0 0
ALK mutants bind TKIs R-HSA-9700645 0.526201 0.279 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 0.526201 0.279 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 0.526201 0.279 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 0.526201 0.279 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 0.526201 0.279 0 0
p75NTR regulates axonogenesis R-HSA-193697 0.526201 0.279 0 0
Regulation of signaling by NODAL R-HSA-1433617 0.526201 0.279 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 0.526201 0.279 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 0.526201 0.279 0 0
Regulated proteolysis of p75NTR R-HSA-193692 0.526201 0.279 0 0
Interleukin-1 processing R-HSA-448706 0.526201 0.279 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 0.526201 0.279 0 0
Cellular response to mitochondrial stress R-HSA-9840373 0.526201 0.279 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 0.527415 0.278 0 0
MET promotes cell motility R-HSA-8875878 0.530837 0.275 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 0.533811 0.273 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 0.533811 0.273 0 0
Translation initiation complex formation R-HSA-72649 0.538625 0.269 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 0.538719 0.269 0 0
Carnitine shuttle R-HSA-200425 0.538719 0.269 0 0
Syndecan interactions R-HSA-3000170 0.538719 0.269 0 0
Cellular responses to stimuli R-HSA-8953897 0.544301 0.264 0 0
Toll-like Receptor Cascades R-HSA-168898 0.545023 0.264 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 0.545558 0.263 0 0
Plasma lipoprotein clearance R-HSA-8964043 0.545558 0.263 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 0.551133 0.259 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 0.554806 0.256 0 0
DNA replication initiation R-HSA-68952 0.554806 0.256 0 0
Folding of actin by CCT/TriC R-HSA-390450 0.554806 0.256 0 0
Regulation of CDH11 function R-HSA-9762292 0.554806 0.256 0 0
Binding and entry of HIV virion R-HSA-173107 0.554806 0.256 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 0.554806 0.256 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 0.554806 0.256 0 0
Formation of intermediate mesoderm R-HSA-9761174 0.554806 0.256 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 0.554806 0.256 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 0.554806 0.256 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 0.554806 0.256 0 0
Pexophagy R-HSA-9664873 0.554806 0.256 0 0
Receptor Mediated Mitophagy R-HSA-8934903 0.554806 0.256 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 0.554806 0.256 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 0.554806 0.256 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 0.556059 0.255 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 0.560005 0.252 0 0
Attenuation phase R-HSA-3371568 0.560005 0.252 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 0.560005 0.252 0 0
Diseases of Immune System R-HSA-5260271 0.560005 0.252 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 0.560005 0.252 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 0.563461 0.249 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 0.563461 0.249 0 0
Ca2+ pathway R-HSA-4086398 0.566985 0.246 0 0
Acyl chain remodelling of PS R-HSA-1482801 0.574674 0.241 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 0.574674 0.241 0 0
Homology Directed Repair R-HSA-5693538 0.577117 0.239 0 0
Signaling by APC mutants R-HSA-4839744 0.581685 0.235 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 0.581685 0.235 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 0.581685 0.235 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 0.581685 0.235 0 0
LGI-ADAM interactions R-HSA-5682910 0.581685 0.235 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 0.581685 0.235 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 0.581685 0.235 0 0
vRNA Synthesis R-HSA-192814 0.581685 0.235 0 0
Synthesis of PI R-HSA-1483226 0.581685 0.235 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 0.581685 0.235 0 0
Bicarbonate transporters R-HSA-425381 0.581685 0.235 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 0.581685 0.235 0 0
DNA Repair R-HSA-73894 0.581901 0.235 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 0.585548 0.232 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 0.585548 0.232 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 0.588413 0.230 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 0.591870 0.228 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 0.591870 0.228 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 0.591870 0.228 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 0.591870 0.228 0 0
TRP channels R-HSA-3295583 0.591870 0.228 0 0
Potential therapeutics for SARS R-HSA-9679191 0.598304 0.223 0 0
Signaling by NOTCH1 R-HSA-1980143 0.598907 0.223 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 0.599293 0.222 0 0
Regulation of beta-cell development R-HSA-186712 0.599293 0.222 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 0.599293 0.222 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 0.601634 0.221 0 0
Co-inhibition by PD-1 R-HSA-389948 0.605059 0.218 0 0
Axon guidance R-HSA-422475 0.606549 0.217 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 0.606943 0.217 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 0.606943 0.217 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 0.606943 0.217 0 0
Signaling by GSK3beta mutants R-HSA-5339716 0.606943 0.217 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 0.606943 0.217 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 0.606943 0.217 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 0.606943 0.217 0 0
Signaling by AXIN mutants R-HSA-4839735 0.606943 0.217 0 0
Signaling by AMER1 mutants R-HSA-4839748 0.606943 0.217 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 0.608541 0.216 0 0
Cristae formation R-HSA-8949613 0.608541 0.216 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 0.610345 0.214 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 0.610345 0.214 0 0
Kinesins R-HSA-983189 0.610837 0.214 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 0.611569 0.214 0 0
Defective pyroptosis R-HSA-9710421 0.614919 0.211 0 0
Nuclear Receptor transcription pathway R-HSA-383280 0.619434 0.208 0 0
PCP/CE pathway R-HSA-4086400 0.619434 0.208 0 0
DNA Double-Strand Break Repair R-HSA-5693532 0.620234 0.207 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 0.622174 0.206 0 0
Nervous system development R-HSA-9675108 0.622979 0.206 0 0
Signaling by ROBO receptors R-HSA-376176 0.624252 0.205 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 0.624689 0.204 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 0.624689 0.204 0 0
Inflammasomes R-HSA-622312 0.624689 0.204 0 0
EPHB-mediated forward signaling R-HSA-3928662 0.627902 0.202 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 0.630678 0.200 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 0.630678 0.200 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 0.630678 0.200 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 0.630678 0.200 0 0
GRB2 events in EGFR signaling R-HSA-179812 0.630678 0.200 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 0.630678 0.200 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 0.630678 0.200 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 0.630678 0.200 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 0.630678 0.200 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 0.630678 0.200 0 0
p75NTR recruits signalling complexes R-HSA-209543 0.630678 0.200 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 0.630678 0.200 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 0.630678 0.200 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 0.630678 0.200 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 0.630678 0.200 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 0.630678 0.200 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 0.630678 0.200 0 0
Interleukin-15 signaling R-HSA-8983432 0.630678 0.200 0 0
ESR-mediated signaling R-HSA-8939211 0.633193 0.198 0 0
PPARA activates gene expression R-HSA-1989781 0.634510 0.198 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 0.639325 0.194 0 0
Late endosomal microautophagy R-HSA-9615710 0.640315 0.194 0 0
Termination of translesion DNA synthesis R-HSA-5656169 0.640315 0.194 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 0.640315 0.194 0 0
Platelet calcium homeostasis R-HSA-418360 0.640315 0.194 0 0
Somitogenesis R-HSA-9824272 0.640581 0.193 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 0.644212 0.191 0 0
Signaling by PTK6 R-HSA-8848021 0.644212 0.191 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 0.644212 0.191 0 0
Signaling by NOTCH R-HSA-157118 0.650488 0.187 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 0.652952 0.185 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 0.652952 0.185 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 0.652980 0.185 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 0.652980 0.185 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 0.652980 0.185 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 0.652980 0.185 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 0.652980 0.185 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 0.654279 0.184 0 0
IGF1R signaling cascade R-HSA-2428924 0.654909 0.184 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 0.655424 0.183 0 0
DAP12 signaling R-HSA-2424491 0.655424 0.183 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 0.655424 0.183 0 0
Interleukin-37 signaling R-HSA-9008059 0.655424 0.183 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 0.659666 0.181 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 0.661228 0.180 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 0.662944 0.179 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 0.665015 0.177 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 0.665387 0.177 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 0.665387 0.177 0 0
Signaling by TGFB family members R-HSA-9006936 0.668910 0.175 0 0
Budding and maturation of HIV virion R-HSA-162588 0.670022 0.174 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 0.670022 0.174 0 0
Cargo concentration in the ER R-HSA-5694530 0.670022 0.174 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 0.673938 0.171 0 0
NRIF signals cell death from the nucleus R-HSA-205043 0.673938 0.171 0 0
Prolactin receptor signaling R-HSA-1170546 0.673938 0.171 0 0
Signaling by FGFR4 in disease R-HSA-5655291 0.673938 0.171 0 0
Regulation of KIT signaling R-HSA-1433559 0.673938 0.171 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 0.673938 0.171 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 0.677121 0.169 0 0
Signaling by WNT in cancer R-HSA-4791275 0.684114 0.165 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 0.684114 0.165 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 0.684114 0.165 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 0.684698 0.165 0 0
DNA Double Strand Break Response R-HSA-5693606 0.685685 0.164 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 0.685685 0.164 0 0
Degradation of CDH1 R-HSA-9766229 0.688218 0.162 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 0.693630 0.159 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 0.693630 0.159 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 0.693630 0.159 0 0
Telomere C-strand synthesis initiation R-HSA-174430 0.693630 0.159 0 0
SHC1 events in EGFR signaling R-HSA-180336 0.693630 0.159 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 0.693630 0.159 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 0.693630 0.159 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 0.693630 0.159 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 0.693630 0.159 0 0
Spry regulation of FGF signaling R-HSA-1295596 0.693630 0.159 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 0.693732 0.159 0 0
Interferon Signaling R-HSA-913531 0.694884 0.158 0 0
Interleukin-1 signaling R-HSA-9020702 0.696218 0.157 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 0.697709 0.156 0 0
Integrin signaling R-HSA-354192 0.697709 0.156 0 0
G-protein beta:gamma signalling R-HSA-397795 0.697709 0.156 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 0.697709 0.156 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 0.697709 0.156 0 0
Regulation of necroptotic cell death R-HSA-5675482 0.697709 0.156 0 0
Cap-dependent Translation Initiation R-HSA-72737 0.698407 0.156 0 0
Eukaryotic Translation Initiation R-HSA-72613 0.698407 0.156 0 0
Signaling by FGFR2 in disease R-HSA-5655253 0.699358 0.155 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 0.701168 0.154 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 0.703677 0.153 0 0
PI Metabolism R-HSA-1483255 0.704184 0.152 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 0.708899 0.149 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 0.710194 0.149 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 0.710815 0.148 0 0
Resolution of D-Loop Structures R-HSA-5693537 0.710815 0.148 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 0.710815 0.148 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 0.710815 0.148 0 0
Miscellaneous transport and binding events R-HSA-5223345 0.710815 0.148 0 0
Phosphorylation of the APC/C R-HSA-176412 0.712135 0.147 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 0.712135 0.147 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 0.712135 0.147 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 0.712135 0.147 0 0
Activation of SMO R-HSA-5635838 0.712135 0.147 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 0.714474 0.146 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 0.720217 0.143 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 0.720726 0.142 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 0.723443 0.141 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 0.723628 0.140 0 0
Regulation of mitotic cell cycle R-HSA-453276 0.723628 0.140 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 0.723628 0.140 0 0
Viral Infection Pathways R-HSA-9824446 0.723924 0.140 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 0.727227 0.138 0 0
Activation of HOX genes during differentiation R-HSA-5619507 0.727227 0.138 0 0
RSV-host interactions R-HSA-9833110 0.727227 0.138 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 0.729522 0.137 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 0.729522 0.137 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 0.729522 0.137 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 0.729522 0.137 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 0.729522 0.137 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 0.729522 0.137 0 0
tRNA modification in the mitochondrion R-HSA-6787450 0.729522 0.137 0 0
Smooth Muscle Contraction R-HSA-445355 0.730958 0.136 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 0.735601 0.133 0 0
Regulation of Apoptosis R-HSA-169911 0.735601 0.133 0 0
PERK regulates gene expression R-HSA-381042 0.735601 0.133 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 0.735601 0.133 0 0
DNA Replication R-HSA-69306 0.735889 0.133 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 0.740893 0.130 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 0.745861 0.127 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 0.745861 0.127 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 0.745861 0.127 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 0.745861 0.127 0 0
Glycogen storage diseases R-HSA-3229121 0.745861 0.127 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 0.745861 0.127 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 0.745861 0.127 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 0.745861 0.127 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 0.745861 0.127 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 0.745861 0.127 0 0
HSF1 activation R-HSA-3371511 0.747300 0.127 0 0
PRC2 methylates histones and DNA R-HSA-212300 0.747300 0.127 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 0.747300 0.127 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 0.747300 0.127 0 0
Regulation of TP53 Degradation R-HSA-6804757 0.747300 0.127 0 0
FGFR2 mutant receptor activation R-HSA-1839126 0.747300 0.127 0 0
Cilium Assembly R-HSA-5617833 0.750423 0.125 0 0
Stimuli-sensing channels R-HSA-2672351 0.755947 0.122 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 0.759577 0.119 0 0
Parasite infection R-HSA-9664407 0.759577 0.119 0 0
Leishmania phagocytosis R-HSA-9664417 0.759577 0.119 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 0.761213 0.118 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 0.761213 0.118 0 0
Presynaptic function of Kainate receptors R-HSA-500657 0.761213 0.118 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 0.761213 0.118 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 0.761213 0.118 0 0
Tie2 Signaling R-HSA-210993 0.761213 0.118 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 0.761213 0.118 0 0
GAB1 signalosome R-HSA-180292 0.761213 0.118 0 0
Mismatch Repair R-HSA-5358508 0.761213 0.118 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 0.765533 0.116 0 0
Interleukin-12 signaling R-HSA-9020591 0.766130 0.116 0 0
IRS-mediated signalling R-HSA-112399 0.768950 0.114 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 0.769367 0.114 0 0
Signaling by Interleukins R-HSA-449147 0.772074 0.112 0 0
Disorders of transmembrane transporters R-HSA-5619115 0.774715 0.111 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 0.775639 0.110 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 0.775639 0.110 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 0.775639 0.110 0 0
Regulation of signaling by CBL R-HSA-912631 0.775639 0.110 0 0
Specification of the neural plate border R-HSA-9834899 0.775639 0.110 0 0
STING mediated induction of host immune responses R-HSA-1834941 0.775639 0.110 0 0
The NLRP3 inflammasome R-HSA-844456 0.775639 0.110 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 0.775639 0.110 0 0
Dual incision in TC-NER R-HSA-6782135 0.777734 0.109 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 0.777734 0.109 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 0.779758 0.108 0 0
Glycogen synthesis R-HSA-3322077 0.789195 0.103 0 0
Negative regulation of MET activity R-HSA-6807004 0.789195 0.103 0 0
Signaling by NODAL R-HSA-1181150 0.789195 0.103 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 0.789195 0.103 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 0.789195 0.103 0 0
Protein hydroxylation R-HSA-9629569 0.789195 0.103 0 0
Generation of second messenger molecules R-HSA-202433 0.789737 0.103 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 0.789737 0.103 0 0
Glycogen metabolism R-HSA-8982491 0.789737 0.103 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 0.794477 0.100 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 0.794477 0.100 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 0.794477 0.100 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 0.794477 0.100 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 0.794477 0.100 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 0.794774 0.100 0 0
Signaling by FGFR2 R-HSA-5654738 0.796314 0.099 0 0
PKR-mediated signaling R-HSA-9833482 0.796314 0.099 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 0.799314 0.097 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 0.799314 0.097 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 0.799314 0.097 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 0.799314 0.097 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 0.799314 0.097 0 0
Maturation of spike protein R-HSA-9694548 0.799314 0.097 0 0
Telomere Maintenance R-HSA-157579 0.800862 0.096 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 0.801932 0.096 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 0.801932 0.096 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 0.801932 0.096 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 0.801932 0.096 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 0.801932 0.096 0 0
Signalling to RAS R-HSA-167044 0.801932 0.096 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 0.801932 0.096 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 0.801932 0.096 0 0
Early Phase of HIV Life Cycle R-HSA-162594 0.801932 0.096 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 0.802446 0.096 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 0.808502 0.092 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 0.808502 0.092 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 0.808502 0.092 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 0.808502 0.092 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 0.808502 0.092 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 0.810154 0.091 0 0
Mitochondrial protein import R-HSA-1268020 0.810154 0.091 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 0.810154 0.091 0 0
Signaling by PDGF R-HSA-186797 0.810154 0.091 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 0.812624 0.090 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 0.813900 0.089 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 0.813900 0.089 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 0.813900 0.089 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 0.813900 0.089 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 0.813900 0.089 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 0.813900 0.089 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 0.813900 0.089 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 0.813900 0.089 0 0
Cytoprotection by HMOX1 R-HSA-9707564 0.816829 0.088 0 0
Insulin receptor signalling cascade R-HSA-74751 0.824809 0.084 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 0.824809 0.084 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 0.825145 0.083 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 0.825145 0.083 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 0.825145 0.083 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 0.825145 0.083 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 0.825145 0.083 0 0
Ethanol oxidation R-HSA-71384 0.825145 0.083 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 0.825145 0.083 0 0
Signaling by KIT in disease R-HSA-9669938 0.825145 0.083 0 0
Signaling by FGFR4 R-HSA-5654743 0.825761 0.083 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 0.828674 0.082 0 0
Interleukin-1 family signaling R-HSA-446652 0.828840 0.082 0 0
Meiosis R-HSA-1500620 0.829539 0.081 0 0
Cytokine Signaling in Immune system R-HSA-1280215 0.830745 0.081 0 0
Cellular response to hypoxia R-HSA-1234174 0.831767 0.080 0 0
DAP12 interactions R-HSA-2172127 0.833855 0.079 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 0.833855 0.079 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 0.834578 0.079 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 0.835712 0.078 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 0.835712 0.078 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 0.835712 0.078 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 0.835712 0.078 0 0
Organic anion transport by SLCO transporters R-HSA-879518 0.835712 0.078 0 0
Formation of the ureteric bud R-HSA-9830674 0.835712 0.078 0 0
Developmental Cell Lineages R-HSA-9734767 0.838727 0.076 0 0
XBP1(S) activates chaperone genes R-HSA-381038 0.841508 0.075 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 0.841607 0.075 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 0.841607 0.075 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 0.841607 0.075 0 0
Signaling by FGFR3 R-HSA-5654741 0.841607 0.075 0 0
Fanconi Anemia Pathway R-HSA-6783310 0.841607 0.075 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 0.841717 0.075 0 0
Opioid Signalling R-HSA-111885 0.841717 0.075 0 0
Chromosome Maintenance R-HSA-73886 0.843867 0.074 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 0.845641 0.073 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 0.845641 0.073 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 0.845641 0.073 0 0
Complex III assembly R-HSA-9865881 0.845641 0.073 0 0
Mitochondrial RNA degradation R-HSA-9836573 0.845641 0.073 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 0.845641 0.073 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 0.847158 0.072 0 0
Chaperonin-mediated protein folding R-HSA-390466 0.847223 0.072 0 0
Interleukin-12 family signaling R-HSA-447115 0.847223 0.072 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 0.849030 0.071 0 0
Long-term potentiation R-HSA-9620244 0.854970 0.068 0 0
Tight junction interactions R-HSA-420029 0.854970 0.068 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 0.854970 0.068 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 0.854970 0.068 0 0
Hyaluronan degradation R-HSA-2160916 0.854970 0.068 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 0.854970 0.068 0 0
Sema4D in semaphorin signaling R-HSA-400685 0.854970 0.068 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 0.854970 0.068 0 0
Laminin interactions R-HSA-3000157 0.854970 0.068 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 0.854970 0.068 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 0.855073 0.068 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 0.856135 0.067 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 0.856135 0.067 0 0
Synthesis of PC R-HSA-1483191 0.856135 0.067 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 0.857269 0.067 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 0.862934 0.064 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 0.863091 0.064 0 0
Base Excision Repair R-HSA-73884 0.863331 0.064 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 0.863736 0.064 0 0
Signaling by EGFR in Cancer R-HSA-1643713 0.863736 0.064 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 0.863736 0.064 0 0
Metalloprotease DUBs R-HSA-5689901 0.863736 0.064 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 0.863736 0.064 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 0.866467 0.062 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 0.866467 0.062 0 0
Hedgehog 'on' state R-HSA-5632684 0.868703 0.061 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 0.871973 0.059 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 0.871973 0.059 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 0.871973 0.059 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 0.871973 0.059 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 0.871973 0.059 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 0.871973 0.059 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 0.871973 0.059 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 0.871973 0.059 0 0
Signaling by FGFR3 in disease R-HSA-5655332 0.871973 0.059 0 0
Insulin processing R-HSA-264876 0.871973 0.059 0 0
IRE1alpha activates chaperones R-HSA-381070 0.873244 0.059 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 0.874111 0.058 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 0.875208 0.058 0 0
TCR signaling R-HSA-202403 0.875413 0.058 0 0
Regulation of RAS by GAPs R-HSA-5658442 0.875654 0.058 0 0
PI3K Cascade R-HSA-109704 0.875654 0.058 0 0
Protein folding R-HSA-391251 0.877964 0.057 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 0.879712 0.056 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 0.879712 0.056 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 0.879712 0.056 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 0.879712 0.056 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 0.881598 0.055 0 0
Collagen formation R-HSA-1474290 0.886947 0.052 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 0.886984 0.052 0 0
DNA methylation R-HSA-5334118 0.886984 0.052 0 0
Regulation of gene expression in beta cells R-HSA-210745 0.886984 0.052 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 0.886984 0.052 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 0.886984 0.052 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 0.886984 0.052 0 0
ER to Golgi Anterograde Transport R-HSA-199977 0.887057 0.052 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 0.887279 0.052 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 0.887279 0.052 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 0.887279 0.052 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 0.887279 0.052 0 0
Protein ubiquitination R-HSA-8852135 0.889169 0.051 0 0
Reproduction R-HSA-1474165 0.890446 0.050 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 0.892705 0.049 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 0.893817 0.049 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 0.893817 0.049 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 0.898291 0.047 0 0
COPI-mediated anterograde transport R-HSA-6807878 0.899340 0.046 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 0.899340 0.046 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 0.900237 0.046 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 0.900237 0.046 0 0
Molecules associated with elastic fibres R-HSA-2129379 0.900237 0.046 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 0.900890 0.045 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 0.902837 0.044 0 0
G alpha (z) signalling events R-HSA-418597 0.902837 0.044 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 0.906269 0.043 0 0
Protein localization R-HSA-9609507 0.906540 0.043 0 0
Signaling by FGFR R-HSA-190236 0.906921 0.042 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 0.907561 0.042 0 0
Ion homeostasis R-HSA-5578775 0.907561 0.042 0 0
Signaling by FGFR1 R-HSA-5654736 0.907561 0.042 0 0
Ub-specific processing proteases R-HSA-5689880 0.909479 0.041 0 0
Muscle contraction R-HSA-397014 0.911276 0.040 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 0.911936 0.040 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 0.911936 0.040 0 0
Integration of energy metabolism R-HSA-163685 0.913476 0.039 0 0
Processing of DNA double-strand break ends R-HSA-5693607 0.914533 0.039 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 0.916398 0.038 0 0
Acyl chain remodelling of PC R-HSA-1482788 0.917262 0.038 0 0
Vpu mediated degradation of CD4 R-HSA-180534 0.917262 0.038 0 0
Extension of Telomeres R-HSA-180786 0.920475 0.036 0 0
Platelet activation, signaling and aggregation R-HSA-76002 0.920544 0.036 0 0
Extracellular matrix organization R-HSA-1474244 0.920638 0.036 0 0
Unfolded Protein Response (UPR) R-HSA-381119 0.921983 0.035 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 0.922265 0.035 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 0.922265 0.035 0 0
NOD1/2 Signaling Pathway R-HSA-168638 0.922265 0.035 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 0.922265 0.035 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 0.922265 0.035 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 0.922265 0.035 0 0
Hyaluronan metabolism R-HSA-2142845 0.922265 0.035 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 0.922265 0.035 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 0.922265 0.035 0 0
Signaling by NOTCH2 R-HSA-1980145 0.922265 0.035 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 0.922265 0.035 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 0.922265 0.035 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 0.924388 0.034 0 0
Signaling by ERBB2 R-HSA-1227986 0.924388 0.034 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 0.926967 0.033 0 0
Acyl chain remodelling of PE R-HSA-1482839 0.926967 0.033 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 0.926967 0.033 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 0.926967 0.033 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 0.926967 0.033 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 0.926967 0.033 0 0
Transferrin endocytosis and recycling R-HSA-917977 0.926967 0.033 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 0.928380 0.032 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 0.931384 0.031 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 0.931384 0.031 0 0
Triglyceride catabolism R-HSA-163560 0.931384 0.031 0 0
GPVI-mediated activation cascade R-HSA-114604 0.931384 0.031 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 0.931504 0.031 0 0
NCAM signaling for neurite out-growth R-HSA-375165 0.931676 0.031 0 0
Neuronal System R-HSA-112316 0.932972 0.030 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 0.933369 0.030 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 0.935534 0.029 0 0
Degradation of DVL R-HSA-4641258 0.935534 0.029 0 0
Degradation of AXIN R-HSA-4641257 0.935534 0.029 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 0.935534 0.029 0 0
Collagen chain trimerization R-HSA-8948216 0.935534 0.029 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 0.939434 0.027 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 0.939434 0.027 0 0
Elastic fibre formation R-HSA-1566948 0.939434 0.027 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 0.939434 0.027 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 0.939434 0.027 0 0
Transmission across Chemical Synapses R-HSA-112315 0.939533 0.027 0 0
Platelet degranulation R-HSA-114608 0.940028 0.027 0 0
Pentose phosphate pathway R-HSA-71336 0.943098 0.025 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 0.943098 0.025 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 0.943098 0.025 0 0
Stabilization of p53 R-HSA-69541 0.943098 0.025 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 0.944304 0.025 0 0
Neurotransmitter release cycle R-HSA-112310 0.945322 0.024 0 0
Downstream TCR signaling R-HSA-202424 0.945322 0.024 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 0.946540 0.024 0 0
FCERI mediated MAPK activation R-HSA-2871796 0.949343 0.023 0 0
Regulated Necrosis R-HSA-5218859 0.949752 0.022 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 0.949752 0.022 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 0.949775 0.022 0 0
FLT3 Signaling R-HSA-9607240 0.949775 0.022 0 0
Signaling by Insulin receptor R-HSA-74752 0.952321 0.021 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 0.952321 0.021 0 0
Adaptive Immune System R-HSA-1280218 0.952757 0.021 0 0
Degradation of CRY and PER proteins R-HSA-9932298 0.952813 0.021 0 0
Intra-Golgi traffic R-HSA-6811438 0.952813 0.021 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 0.952813 0.021 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 0.952813 0.021 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 0.954462 0.020 0 0
COPII-mediated vesicle transport R-HSA-204005 0.954690 0.020 0 0
Phospholipid metabolism R-HSA-1483257 0.954896 0.020 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 0.955669 0.020 0 0
Depyrimidination R-HSA-73928 0.955669 0.020 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 0.956981 0.019 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 0.958351 0.018 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 0.958351 0.018 0 0
Signaling by SCF-KIT R-HSA-1433557 0.958351 0.018 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 0.958951 0.018 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 0.960872 0.017 0 0
Amine ligand-binding receptors R-HSA-375280 0.960872 0.017 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 0.960872 0.017 0 0
Proteasome assembly R-HSA-9907900 0.960872 0.017 0 0
Surfactant metabolism R-HSA-5683826 0.960872 0.017 0 0
Cellular response to starvation R-HSA-9711097 0.962126 0.017 0 0
Signaling by ERBB4 R-HSA-1236394 0.963208 0.016 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 0.963240 0.016 0 0
Nucleosome assembly R-HSA-774815 0.963240 0.016 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 0.963240 0.016 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 0.963240 0.016 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 0.963240 0.016 0 0
Signaling by Nuclear Receptors R-HSA-9006931 0.964697 0.016 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 0.965464 0.015 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 0.965464 0.015 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 0.965464 0.015 0 0
Diseases of DNA repair R-HSA-9675135 0.965464 0.015 0 0
Post-translational protein phosphorylation R-HSA-8957275 0.965529 0.015 0 0
Translation of Structural Proteins R-HSA-9694635 0.968565 0.014 0 0
Co-stimulation by CD28 R-HSA-389356 0.969519 0.013 0 0
Metal ion SLC transporters R-HSA-425410 0.969519 0.013 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 0.970061 0.013 0 0
SLC-mediated transport of organic anions R-HSA-9955298 0.970177 0.013 0 0
Integrin cell surface interactions R-HSA-216083 0.970177 0.013 0 0
Cholesterol biosynthesis R-HSA-191273 0.970177 0.013 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 0.971364 0.013 0 0
Chemokine receptors bind chemokines R-HSA-380108 0.971364 0.013 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 0.971364 0.013 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 0.971364 0.013 0 0
Formation of the cornified envelope R-HSA-6809371 0.972122 0.012 0 0
Response of endothelial cells to shear stress R-HSA-9860931 0.974025 0.011 0 0
Amyloid fiber formation R-HSA-977225 0.974549 0.011 0 0
Complex IV assembly R-HSA-9864848 0.974726 0.011 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 0.974726 0.011 0 0
Hedgehog ligand biogenesis R-HSA-5358346 0.974726 0.011 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 0.976256 0.010 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 0.976256 0.010 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 0.976963 0.010 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 0.977113 0.010 0 0
Amino acids regulate mTORC1 R-HSA-9639288 0.977694 0.010 0 0
Regulation of PTEN stability and activity R-HSA-8948751 0.977694 0.010 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 0.979045 0.009 0 0
Antigen processing-Cross presentation R-HSA-1236975 0.979546 0.009 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 0.980430 0.009 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 0.981506 0.008 0 0
Neddylation R-HSA-8951664 0.982576 0.008 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 0.983139 0.007 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 0.983139 0.007 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 0.983678 0.007 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 0.983982 0.007 0 0
ER-Phagosome pathway R-HSA-1236974 0.984260 0.007 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 0.984582 0.007 0 0
Peroxisomal protein import R-HSA-9033241 0.984667 0.007 0 0
Triglyceride metabolism R-HSA-8979227 0.984667 0.007 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 0.984700 0.007 0 0
Interferon gamma signaling R-HSA-877300 0.985422 0.006 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 0.985428 0.006 0 0
Metabolism of polyamines R-HSA-351202 0.985596 0.006 0 0
Collagen degradation R-HSA-1442490 0.986468 0.006 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 0.986610 0.006 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 0.987288 0.006 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 0.987315 0.006 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 0.988058 0.005 0 0
Complex I biogenesis R-HSA-6799198 0.988058 0.005 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 0.988058 0.005 0 0
Semaphorin interactions R-HSA-373755 0.988058 0.005 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 0.988617 0.005 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 0.988777 0.005 0 0
Ion channel transport R-HSA-983712 0.989227 0.005 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 0.989789 0.004 0 0
Kidney development R-HSA-9830369 0.990700 0.004 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 0.991264 0.004 0 0
Regulation of insulin secretion R-HSA-422356 0.991329 0.004 0 0
Hedgehog 'off' state R-HSA-5610787 0.992227 0.003 0 0
ABC-family proteins mediated transport R-HSA-382556 0.992227 0.003 0 0
ECM proteoglycans R-HSA-3000178 0.992758 0.003 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 0.992758 0.003 0 0
Metabolism of cofactors R-HSA-8978934 0.992758 0.003 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 0.993609 0.003 0 0
ROS and RNS production in phagocytes R-HSA-1222556 0.993997 0.003 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 0.994361 0.002 0 0
Iron uptake and transport R-HSA-917937 0.994361 0.002 0 0
Platelet homeostasis R-HSA-418346 0.994709 0.002 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 0.994993 0.002 0 0
ABC transporter disorders R-HSA-5619084 0.995326 0.002 0 0
Parasitic Infection Pathways R-HSA-9824443 0.995708 0.002 0 0
Leishmania infection R-HSA-9658195 0.995708 0.002 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 0.995875 0.002 0 0
Post-translational protein modification R-HSA-597592 0.996266 0.002 0 0
Signaling by Hedgehog R-HSA-5358351 0.996408 0.002 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 0.997338 0.001 0 0
FCERI mediated NF-kB activation R-HSA-2871837 0.997493 0.001 0 0
Peptide chain elongation R-HSA-156902 0.997652 0.001 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 0.997881 0.001 0 0
Hemostasis R-HSA-109582 0.997887 0.001 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 0.997928 0.001 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 0.998054 0.001 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 0.998163 0.001 0 0
Eukaryotic Translation Elongation R-HSA-156842 0.998283 0.001 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 0.998344 0.001 0 0
rRNA processing R-HSA-72312 0.998366 0.001 0 0
Mitochondrial protein degradation R-HSA-9837999 0.998485 0.001 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 0.998577 0.001 0 0
Eukaryotic Translation Termination R-HSA-72764 0.998663 0.001 0 0
Formation of a pool of free 40S subunits R-HSA-72689 0.998663 0.001 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 0.998745 0.001 0 0
Potassium Channels R-HSA-1296071 0.998745 0.001 0 0
Immune System R-HSA-168256 0.998745 0.001 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 0.998830 0.001 0 0
Cardiac conduction R-HSA-5576891 0.998955 0.000 0 0
Selenocysteine synthesis R-HSA-2408557 0.999082 0.000 0 0
Viral mRNA Translation R-HSA-192823 0.999190 0.000 0 0
Infectious disease R-HSA-5663205 0.999334 0.000 0 0
Ribosome-associated quality control R-HSA-9948299 0.999336 0.000 0 0
Antimicrobial peptides R-HSA-6803157 0.999539 0.000 0 0
Keratinization R-HSA-6805567 0.999577 0.000 0 0
G alpha (q) signalling events R-HSA-416476 0.999620 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 0.999684 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 0.999721 0.000 0 0
Regulation of Complement cascade R-HSA-977606 0.999831 0.000 0 0
Neutrophil degranulation R-HSA-6798695 0.999834 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 0.999876 0.000 0 0
Disease R-HSA-1643685 0.999885 0.000 0 0
Sensory perception of taste R-HSA-9717189 0.999898 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 0.999904 0.000 0 0
Metabolism of steroids R-HSA-8957322 0.999919 0.000 0 0
Innate Immune System R-HSA-168249 0.999933 0.000 0 0
Respiratory electron transport R-HSA-611105 0.999941 0.000 0 0
Complement cascade R-HSA-166658 0.999963 0.000 0 0
Metabolism of nucleotides R-HSA-15869 0.999984 0.000 0 0
Sphingolipid metabolism R-HSA-428157 0.999985 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 0.999985 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 0.999989 0.000 0 0
Translation R-HSA-72766 0.999993 0.000 0 0
G alpha (s) signalling events R-HSA-418555 0.999993 0.000 0 0
Diseases of glycosylation R-HSA-3781865 0.999997 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 0.999997 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 0.999997 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 0.999998 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 0.999998 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 0.999999 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000 0.000 0 0
G alpha (i) signalling events R-HSA-418594 1.000000 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000 0.000 0 0
Biological oxidations R-HSA-211859 1.000000 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000 0.000 0 0
Metabolism R-HSA-1430728 1.000000 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways