P70S6K

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A0MZ66 S493 Sugiyama SHTN1 KIAA1598 sEtELERILRRRKVtAEADsssPtGILAtsEsKsMPVLGsV
A0MZ66 S502 Sugiyama SHTN1 KIAA1598 RRRKVtAEADsssPtGILAtsEsKsMPVLGsVssVTKTALN
A0MZ66 S504 Sugiyama SHTN1 KIAA1598 RKVtAEADsssPtGILAtsEsKsMPVLGsVssVTKTALNKK
A0MZ66 T487 Sugiyama SHTN1 KIAA1598 sLDPENsEtELERILRRRKVtAEADsssPtGILAtsEsKsM
A5A3E0 T949 Sugiyama POTEF A26C1B TVAsSSSLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
O00418 S366 SIGNOR|ELM|iPTMNet|PSP EEF2K AKtILRGtEEKCGsPQVRTLsGSRPPLLRPLsENSGDENMS
O00512 S104 Sugiyama BCL9 GLKNGAGNGAKGKGKRERsIsADsFDQRDPGtPNDDsDIKE
O00571 S606 Sugiyama DDX3X DBX DDX3 GRSKssRFsGGFGARDYRQssGAssssFsssRAsSsRSGGG
O14734 S315 Sugiyama ACOT8 ACTEIII PTE1 DGVLAVTCAQEGVIRVKPQVsESKL________________
O14974 S695 Sugiyama PPP1R12A MBS MYPT1 DEEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSR
O14974 S910 Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O14974 S995 Sugiyama PPP1R12A MBS MYPT1 ADRSLLEMEKRERRALERRIsEMEEELKMLPDLKADNQRLK
O14974 T696 Sugiyama PPP1R12A MBS MYPT1 EEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSRS
O14974 T700 Sugiyama PPP1R12A MBS MYPT1 sQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSRSTRTR
O14980 S1055 Sugiyama XPO1 CRM1 LEEREIALRQADEEKHKRQMsVPGIFNPHEIPEEMCD____
O15143 S328 Sugiyama ARPC1B ARC41 KAssEGGtAAGAGLDsLHKNsVsQIsVLsGGKAKCSQFCTT
O15357 S1176 Sugiyama INPPL1 SHIP2 RGLPsDyGRPLsFPPPRIREsIQEDLAEEAPCLQGGRASGL
O15372 S290 Sugiyama EIF3H EIF3S3 QQQQKHQYQQRRQQENMQRQsRGEPPLPEEDLsKLFKPPQP
O15530 S549 SIGNOR PDPK1 PDK1 SGNAHKWCRKIQEVWRQRYQsHPDAAVQ_____________
O43379 S49 Sugiyama WDR62 C19orf14 RGQssPPPAPPICLRRRtRLstAsEETVQNRVsLEKVLGIT
O43379 S52 Sugiyama WDR62 C19orf14 ssPPPAPPICLRRRtRLstAsEETVQNRVsLEKVLGITAQN
O43379 T50 Sugiyama WDR62 C19orf14 GQssPPPAPPICLRRRtRLstAsEETVQNRVsLEKVLGITA
O43390 S428 Sugiyama HNRNPR HNRPR LAKPPDKKRKERQAARQAsRstAyEDyyyHPPPRMPPPIRG
O43818 S53 Sugiyama RRP9 RNU3IP2 U355K AGDRGKSKGGGKMNEEIssDsEsEsLAPRKPEEEEEEELEE
O43823 S323 Sugiyama AKAP8 AKAP95 RKRKQFQLyEEPDtKLARVDsEGDFsENDDAAGDFRsGDEE
O43847 S94 Sugiyama NRDC NRD1 ENSRVARLGADEsEEEGRRGsLsNAGDPEIVKsPsDPKQYR
O43847 T59 Sugiyama NRDC NRD1 SAAARPFPILAMPGRNKAKstCsCPDLQPNGQDLGENSRVA
O60220 S94 Sugiyama TIMM8A DDP DDP1 TIM8A SQFILNRLEQTQKSKPVFSEsLsD_________________
O60264 S137 Sugiyama SMARCA5 SNF2H WCRF135 PLKMKPGRPRIKKDEKQNLLsVGDyRHRRTEQEEDEELLTE
O60293 S42 Sugiyama ZFC3H1 CCDC131 KIAA0546 PSRC2 LEDGEIsDDDNNSQIRSRsssSsSGGGLLPYPRRRPPHSAR
O60331 S555 SIGNOR|PSP PIP5K1C KIAA0589 IPERSPsETSEQPRYRRRtQssGQDGRPQEEPPAEEDLQQI
O60331 T553 SIGNOR|PSP PIP5K1C KIAA0589 LSIPERSPsETSEQPRYRRRtQssGQDGRPQEEPPAEEDLQ
O60343 S754 Sugiyama TBC1D4 AS160 KIAA0603 QDTASESSDGEGRKRtSstCsNEsLsVGGTSVTPRRISWRQ
O60343 T749 Sugiyama TBC1D4 AS160 KIAA0603 ENEIRQDTASESSDGEGRKRtSstCsNEsLsVGGTSVTPRR
O60739 T46 Sugiyama EIF1B GTEDyIHIRIQQRNGRKtLttVQGIADDyDKKKLVKAFKKK
O60814 S37 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
O60814 S39 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
O60814 Y38 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK AVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
O60825 S466 SIGNOR PFKFB2 RDKPTNNFPKNQTPVRMRRNsFtPLsssNtIRRPRNYsVGs
O60832 S453 Sugiyama DKC1 NOLA4 KAPQVVAEAAKTAKRKREsEsEsDEtPPAAPQLIKKEKKKS
O60841 S182 Sugiyama EIF5B IF2 KIAA0741 DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O60841 S183 Sugiyama EIF5B IF2 KIAA0741 GsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKN
O75030 S409 SIGNOR MITF BHLHE32 LLRIQELEMQARAHGLsLIPsTGLCsPDLVNRIIKQEPVLE
O75122 S621 Sugiyama CLASP2 KIAA0627 AVADALKKPARRRyEsYGMHsDDDANSDASSACSERSYSSR
O75122 Y614 Sugiyama CLASP2 KIAA0627 tGsDVEEAVADALKKPARRRyEsYGMHsDDDANSDASSACS
O75400 S927 Sugiyama PRPF40A FBP11 FLAF1 FNBP3 HIP10 HYPA HSPC225 RTRQRSESKHKSPKKKtGKDsGNWDtsGsELsEGELEKRRR
O75400 T923 Sugiyama PRPF40A FBP11 FLAF1 FNBP3 HIP10 HYPA HSPC225 SEKDRTRQRSESKHKSPKKKtGKDsGNWDtsGsELsEGELE
O75534 T761 Sugiyama CSDE1 D1S155E KIAA0885 NRU UNR GPKAVAAPRPDRLVNRLKNItLDDAsAPRLMVLRQPRGPDN
O75821 S189 Sugiyama EIF3G EIF3S4 CPYKDtLGPMQKELAEQLGLstGEKEKLPGELEPVQAtQNK
O75937 S81 Sugiyama DNAJC8 SPF31 HSPC315 HSPC331 VLQIDPEVTDEEIKKRFRQLsILVHPDKNQDDADRAQKAFE
O76021 S314 Sugiyama RSL1D1 CATX11 CSIG PBK1 L12 RNFEKQKERKKKRQQARKtAsVLsKDDVAPEsGDtTVKKPE
O94763 S372 SIGNOR|PSP URI1 C19orf2 NNX3 PPP1R19 RMP URI KNTTLKFSEKKEEAKRKRKNstGsGHsAQELPTIRTPADIY
O94776 S52 Sugiyama MTA2 MTA1L1 PID KTANGNVEAKVVCLFRRRDIsssLNSLADSNAREFEEESKQ
O95218 S181 Sugiyama ZRANB2 ZIS ZNF265 DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
O95239 S801 Sugiyama KIF4A KIF4 LKEKKESGENPPPKLRRRtFsLtEVRGQVsEsEDsItKQIE
O95249 T55 Sugiyama GOSR1 GS28 TSYSHSsTRDGRRDRYssDTtPLLNGSSQDRMFETMAIEIE
O95831 S116 Sugiyama AIFM1 AIF PDCD8 NERIsGLGLtPEQKQKKAALsAsEGEEVPQDKAPSHVPFLL
P00491 S176 Sugiyama PNP NP GDRFPAMsDAyDRtMRQRALstWKQMGEQRELQEGTYVMVA
P00558 S175 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 SKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKELN
P01100 S362 SIGNOR FOS G0S7 VFTYPEADSFPSCAAAHRKGsSsNEPSSDSLSsPTLLAL__
P01100 S374 SIGNOR FOS G0S7 CAAAHRKGsSsNEPSSDSLSsPTLLAL______________
P02545 S437 Sugiyama LMNA LMN1 KKRKLEstEsRssFsQHARtsGRVAVEEVDEEGKFVRLRNK
P03372 S167 SIGNOR|PSP ESR1 ESR NR3A1 PAFYRPNsDNRRQGGRERLAsTNDKGSMAMESAKETRYCAV
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792 S15 SIGNOR HSPB1 HSP27 HSP28 ______MTERRVPFsLLRGPsWDPFRDWyPHsRLFDQAFGL
P04792 S78 SIGNOR|ELM HSPB1 HSP27 HSP28 LPPAAIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVs
P04792 S82 SIGNOR|ELM|Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05783 S53 ELM KRT18 CYK18 PIG46 AsVyAGAGGsGsRIsVsRstsFRGGMGsGGLAtGIAGGLAG
P05787 S475 Sugiyama KRT8 CYK8 TSSSRAVVVKKIETRDGKLVsEssDVLPK____________
P06493 S39 PSP CDK1 CDC2 CDC28A CDKN1 P34CDC2 yKGRHKTTGQVVAMKKIRLEsEEEGVPstAIREIsLLKELR
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06899 S37 Sugiyama H2BC11 H2BFR HIST1H2BJ KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISS
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07339 S37 Sugiyama CTSD CPSD PASALVRIPLHKFTSIRRtMsEVGGsVEDLIAKGPVSKYSQ
P07814 S1336 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 SEEDKEALIAKCNDYRRRLLsVNIRVRADLRDNysPGWKFN
P07814 S335 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 PIEKNLQMWEEMKKGsQFGQsCCLRAKIDMSSNNGCMRDPt
P07814 S739 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 TKVEATKNETSAPFKERPtPsLNNNCttsEDsLVLyNRVAV
P07814 S880 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 LKAQYKEKTGKEyIPGQPPLsQssDssPtRNsEPAGLEtPE
P07814 S999 PSP EPRS1 EPRS GLNS PARS QARS QPRS PIG32 QKQNDGQRKDPsKNQGGGLsssGAGEGQGPKKQTRLGLEAK
P07814 T745 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 KNETSAPFKERPtPsLNNNCttsEDsLVLyNRVAVQGDVVR
P07900 S50 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MSLIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKL
P07900 T317 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA WtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P07942 S1115 Sugiyama LAMB1 SCNEFTGQCQCMPGFGGRTCsECQELFWGDPDVECRACDCD
P08151 S84 SIGNOR|PSP GLI1 GLI EGPLFSSPRSAVKLTKKRALsISPLSDASLDLQTVIRTsPS
P08238 S45 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238 S452 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB AFSKNLKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEy
P08238 S460 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 S468 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238 S470 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB RLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItGEs
P08238 S535 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB EPIDEyCVQQLKEFDGKsLVsVtKEGLELPEDEEEKKKMEE
P08238 T309 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB WtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08238 T85 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB LDsGKELKIDIIPNPQERtLtLVDtGIGMtKADLINNLGtI
P08238 Y457 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB LKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMK
P08670 S325 Sugiyama VIM NNDALRQAKQESTEYRRQVQsLtCEVDALKGtNEsLERQMR
P08758 T8 Sugiyama ANXA5 ANX5 ENX2 PP4 _____________MAQVLRGtVtDFPGFDERADAEtLRKAM
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P10412 S36 Sugiyama H1-4 H1F4 HIST1H1E EKtPVKKKARKsAGAAKRKAsGPPVsELItKAVAASKERsG
P10809 S398 Sugiyama HSPD1 HSP60 LDVttsEyEKEKLNERLAKLsDGVAVLKVGGtsDVEVNEKK
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11274 Y246 Sugiyama BCR BCR1 D22S11 ASRPPYRGRssEssCGVDGDyEDAELNPRFLKDNLIDANGG
P11940 T191 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 GRFKSRKEREAELGARAKEFtNVyIKNFGEDMDDERLKDLF
P12270 S1185 Sugiyama TPR KLSDKVVASVKEGVQGPLNVsLsEEGKSQEQILEILRFIRR
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 S593 Sugiyama EEF2 EF2 SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13667 S468 Sugiyama PDIA4 ERP70 ERP72 ytFAIADEEDyAGEVKDLGLsEsGEDVNAAILDEsGKKFAM
P13667 S470 Sugiyama PDIA4 ERP70 ERP72 FAIADEEDyAGEVKDLGLsEsGEDVNAAILDEsGKKFAMEP
P13797 S120 Sugiyama PLS3 KEGICALGGTsELssEGtQHsysEEEKyAFVNWINKALEND
P13861 S58 Sugiyama PRKAR2A PKR2 PRKAR2 TRLREARAPAsVLPAAtPRQsLGHPPPEPGPDRVADAKGDs
P13861 S78 Sugiyama PRKAR2A PKR2 PRKAR2 sLGHPPPEPGPDRVADAKGDsEsEEDEDLEVPVPsRFNRRV
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14618 T95 Sugiyama PKM OIP3 PK2 PK3 PKM2 NFsHGtHEyHAEtIKNVRtAtEsFAsDPILyRPVAVALDTK
P14625 S106 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625 S515 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 GVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQ
P14649 S87 Sugiyama MYL6B MLC1SA EEFKEAFELFDRVGDGKILysQCGDVMRALGQNPtNAEVLK
P15311 T533 Sugiyama EZR VIL2 NEEKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDII
P15531 S120 Sugiyama NME1 NDPKA NM23 KPGtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELV
P16220 S119 SIGNOR CREB1 EsVDsVTDsQKRREILsRRPsYRKILNDLssDAPGVPRIEE
P16402 S37 Sugiyama H1-3 H1F3 HIST1H1D KtPVKKKAKKAGATAGKRKAsGPPVsELItKAVAASKERsG
P16403 S36 Sugiyama H1-2 H1F2 HIST1H1C EKAPVKKKAAKKAGGtPRKAsGPPVsELItKAVAASKERsG
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17655 T464 Sugiyama CAPN2 CANPL2 TNIHLSKNFFLTNRARERsDtFINLREVLNRFKLPPGEYIL
P17812 S573 Sugiyama CTPS1 CTPS HYLQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD__
P17987 S35 Sugiyama TCP1 CCT1 CCTA EtIRsQNVMAAAsIANIVKssLGPVGLDKMLVDDIGDVTIT
P17987 S551 Sugiyama TCP1 CCT1 CCTA IKLHPESKDDKHGsyEDAVHsGALND_______________
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P19338 S458 Sugiyama NCL TEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKN
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19634 S703 SIGNOR SLC9A1 APNH1 NHE1 yLtVPAHKLDsPtMsRARIGsDPLAyEPKEDLPVItIDPAs
P20042 S158 Sugiyama EIF2S2 EIF2B EILEKDEALEDEDNKKDDGIsFsNQtGPAWAGSERDytyEE
P20042 T163 Sugiyama EIF2S2 EIF2B DEALEDEDNKKDDGIsFsNQtGPAWAGSERDytyEELLNRV
P20810 S366 Sugiyama CAST DKDGKPLLPEPEEKPKPRsEsELIDELsEDFDRsECKEKPS
P21333 S1301 Sugiyama FLNA FLN FLN1 DARALtQtGGPHVKARVANPsGNLTEtyVQDRGDGMYKVEy
P21333 S2152 SIGNOR FLNA FLN FLN1 VKVTGEGRVKEsITRRRRAPsVANVGsHCDLsLKIPEIsIQ
P22033 S481 Sugiyama MMUT MUT EGIPKLRIEECAARRQARIDsGSEVIVGVNKYQLEKEDAVE
P22087 S124 Sugiyama FBL FIB1 FLRN DALVTKNLVPGEsVyGEKRVsIsEGDDKIEyRAWNPFRSKL
P22314 S46 Sugiyama UBA1 A1S9T UBE1 AQsVLsEVPSVPTNGMAKNGsEADIDEGLysRQLyVLGHEA
P23142 S247 Sugiyama FBLN1 PP213 CRLGESCINTVGSFRCQRDssCGtGYELTEDNSCKDIDECE
P23381 S351 Sugiyama WARS1 IFI53 WARS WRS KPALLHSTFFPALQGAQTKMsAsDPNssIFLtDtAKQIKTK
P23381 S353 Sugiyama WARS1 IFI53 WARS WRS ALLHSTFFPALQGAQTKMsAsDPNssIFLtDtAKQIKTKVN
P23396 T221 Sugiyama RPS3 OK/SW-cl.26 KKPLPDHVsIVEPKDEILPttPIsEQKGGKPEPPAMPQPVP
P23443 S375 Sugiyama RPS6KB1 STK14A INWEELLARKVEPPFKPLLQsEEDVsQFDSKFtRQtPVDsP
P23443 S380 Sugiyama RPS6KB1 STK14A LLARKVEPPFKPLLQsEEDVsQFDSKFtRQtPVDsPDDstL
P23443 S75 Sugiyama RPS6KB1 STK14A DHGGVGPYELGMEHCEKFEIsEtsVNRGPEKIRPECFELLR
P23443 S78 Sugiyama RPS6KB1 STK14A GVGPYELGMEHCEKFEIsEtsVNRGPEKIRPECFELLRVLG
P23443 T412 ELM|PSP RPS6KB1 STK14A VDsPDDstLsEsANQVFLGFtYVAPSVLESVKEKFsFEPKI
P23443 T77 Sugiyama RPS6KB1 STK14A GGVGPYELGMEHCEKFEIsEtsVNRGPEKIRPECFELLRVL
P23443 Y11 Sugiyama RPS6KB1 STK14A __________MRRRRRRDGFyPAPDFRDREAEDMAGVFDID
P23527 S37 Sugiyama H2BC17 H2BFH H2BFN HIST1H2BO KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISS
P23588 S207 Sugiyama EIF4B DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P23588 S422 SIGNOR|ELM|iPTMNet|PSP EIF4B ERHPsWRsEEtQERERsRtGsEssQtGtstTssRNARRREs
P24941 T39 Sugiyama CDK2 CDKN2 yKARNKLTGEVVALKKIRLDtETEGVPstAIREIsLLKELN
P25205 S447 Sugiyama MCM3 EQGRVTIAKAGIHARLNARCsVLAAANPVyGRyDQyKTPME
P25786 S211 Sugiyama PSMA1 HC2 NU PROS30 PSC2 GLRALRETLPAEQDLttKNVsIGIVGKDLEFTIyDDDDVsP
P26038 S440 Sugiyama MSN EMAELtARIsQLEMARQKKEsEAVEWQQKAQMVQEDLEKTR
P26038 S527 Sugiyama MSN ERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHAE
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P26232 S654 Sugiyama CTNNA2 CAPR EELEDDsDFEQEDYDVRsRtsVQtEDDQLIAGQsARAIMAQ
P26373 S109 Sugiyama RPL13 BBC1 OK/SW-cl.46 KVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILFPR
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373 T24 Sugiyama RPL13 BBC1 OK/SW-cl.46 SRNGMVLKPHFHKDWQRRVAtWFNQPARKIRRRKARQAKAR
P26639 S522 Sugiyama TARS1 TARS PEKFLGDIEVWDQAEKQLENsLNEFGEKWELNsGDGAFyGP
P26639 S702 Sugiyama TARS1 TARS ISGTVNIRTRDNKVHGERtIsEtIERLQQLKEFRSKQAEEE
P26641 T287 Sugiyama EEF1G EF1G PRO1608 EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P27540 S271 Sugiyama ARNT BHLHE2 SSMRMCMGSRRSFICRMRCGsSSVDPVSVNRLSFVRNRCRN
P27708 S1859 SIGNOR|PSP|Sugiyama CAD RGIPGLPDGRFHLPPRIHRAsDPGLPAEEPKEKSSRKVAEP
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P27824 S362 Sugiyama CANX WDEDMDGEWEAPQIANPRCEsAPGCGVWQRPVIDNPNyKGK
P28066 S174 Sugiyama PSMA5 FHMDPsGtFVQCDARAIGsAsEGAQssLQEVyHKSMTLKEA
P30050 S138 Sugiyama RPL12 HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30086 T51 Sugiyama PEBP1 PBP PEBP GAAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDP
P30304 S293 SIGNOR CDC25A LKRPERsQEEsPPGSTKRRKsMsGASPKESTNPEKAHETLH
P30304 S295 SIGNOR CDC25A RPERsQEEsPPGSTKRRKsMsGASPKESTNPEKAHETLHQS
P30305 S353 SIGNOR CDC25B CDC25HU2 LKRLERPQDRDTPVQNKRRRsVtPPEEQQEAEEPKARVLRs
P30305 T355 SIGNOR CDC25B CDC25HU2 RLERPQDRDTPVQNKRRRsVtPPEEQQEAEEPKARVLRsKs
P30533 S137 Sugiyama LRPAP1 A2MRAP VILAKYGLDGKKDARQVtsNsLsGtQEDGLDDPRLEKLWHK
P30533 S242 Sugiyama LRPAP1 A2MRAP TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P30533 T248 Sugiyama LRPAP1 A2MRAP LRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWDLAQSAN
P31327 S896 Sugiyama CPS1 WFLYKMRDILNMEKTLKGLNsEsMtEEtLKRAKEIGFSDKQ
P32004 S1152 SIGNOR L1CAM CAML1 MIC5 LLLLVLLILCFIKRSKGGKysVKDKEDtQVDsEARPMKDEt
P32119 T142 Sugiyama PRDX2 NKEFB TDPX1 EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P32969 S135 Sugiyama RPL9 OK/SW-cl.103; RPL9P7; RPL9P8; RPL9P9 RNFLGEKYIRRVRMRPGVACsVsQAQKDELILEGNDIELVS
P33316 S120 Sugiyama DUT PsKRARPAEVGGMQLRFARLsEHAtAPTRGsARAAGYDLYS
P33778 S37 Sugiyama H2BC3 H2BFF HIST1H2BB KAITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISS
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34932 S647 Sugiyama HSPA4 APG2 HSPH2 EMRDKLSGEYEKFVSEDDRNsFtLKLEDTENWLyEDGEDQP
P34932 S76 Sugiyama HSPA4 APG2 HSPH2 VISNAKNTVQGFKRFHGRAFsDPFVEAEKSNLAYDIVQLPT
P35221 S655 Sugiyama CTNNA1 PEELDDsDFEtEDFDVRsRtsVQtEDDQLIAGQsARAIMAQ
P35269 T156 Sugiyama GTF2F1 RAP74 EAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHFSI
P35568 S1101 SIGNOR|PSP IRS1 RNQSAKVIRADPQGCRRRHssEtFsstPSATRVGNTVPFGA
P35568 S270 SIGNOR|PSP IRS1 HETILEAMRAMSDEFRPRsKsQsssNCSNPISVPLRRHHLN
P35568 S307 SIGNOR|PSP IRS1 HHLNNPPPSQVGLTRRsRtEsItAtsPAsMVGGKPGsFRVR
P35568 S527 SIGNOR|PSP IRS1 AGDEAASAADLDNRFRKRtHsAGtsPTITHQKTPSQSSVAs
P35568 S636 SIGNOR|PSP IRS1 sPGVAPVPSGRKGsGDyMPMsPKsVSAPQQIINPIRRHPQR
P35568 S639 SIGNOR IRS1 VAPVPSGRKGsGDyMPMsPKsVSAPQQIINPIRRHPQRVDP
P35659 S301 Sugiyama DEK NVKKADSSTTKKNQNSSKKEsEsEDssDDEPLIKKLKKPPT
P36578 S66 Sugiyama RPL4 RPL1 KNNRQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGGGtHR
P36578 S87 Sugiyama RPL4 RPL1 WGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAPTKT
P36578 T84 Sugiyama RPL4 RPL1 AEsWGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAP
P36578 Y52 Sugiyama RPL4 RPL1 IRPDIVNFVHTNLRKNNRQPyAVsELAGHQtsAEsWGtGRA
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37837 S13 Sugiyama TALDO1 TAL TALDO TALDOR ________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39023 S265 Sugiyama RPL3 OK/SW-cl.32 HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P41567 T46 Sugiyama EIF1 SUI1 GTEDyIHIRIQQRNGRKtLttVQGIADDyDKKKLVKAFKKK
P42224 S708 Sugiyama STAT1 PEPMELDGPKGtGyIKtELIsVsEVHPSRLQttDNLLPMsP
P42345 S2448 SIGNOR|ELM|iPTMNet|PSP MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1 NWRLMDTNTKGNKRsRtRtDsYsAGQsVEILDGVELGEPAH
P42345 T2446 SIGNOR|ELM|PSP MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1 LLNWRLMDTNTKGNKRsRtRtDsYsAGQsVEILDGVELGEP
P42677 T74 Sugiyama RPS27 MPS1 VLCVGCSTVLCQPTGGKARLtEGCsFRRKQH__________
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43243 S195 Sugiyama MATR3 KIAA0723 RDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRsQEsGyyD
P43243 S234 Sugiyama MATR3 KIAA0723 yDRMDyEDDRLRDGERCRDDsFFGEtsHNyHKFDsEyERMG
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46013 S651 Sugiyama MKI67 ISRsQHDILQMICSKRRsGAsEANLIVAKSWADVVKLGAKQ
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777 S185 Sugiyama RPL5 MSTP030 GAVDGGLsIPHstKRFPGyDsEsKEFNAEVHRKHIMGQNVA
P46777 S187 Sugiyama RPL5 MSTP030 VDGGLsIPHstKRFPGyDsEsKEFNAEVHRKHIMGQNVADy
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46779 T75 Sugiyama RPL28 ADGKGVVVVIKRRSGQRKPAtsyVRttINKNARAtLsSIRH
P46779 T81 Sugiyama RPL28 VVVIKRRSGQRKPAtsyVRttINKNARAtLsSIRHMIRKNK
P47712 S727 Sugiyama PLA2G4A CPLA2 PLA2G4 VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P47712 S729 Sugiyama PLA2G4A CPLA2 PLA2G4 KEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKPKA
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49321 S706 Sugiyama NASP GGGssVsMIASRKPtDGAsssNCVTDIsHLVRKKRKPEEEs
P49321 T700 Sugiyama NASP sGFtPGGGGssVsMIASRKPtDGAsssNCVTDIsHLVRKKR
P49419 S84 Sugiyama ALDH7A1 ATQ1 EVIttyCPANNEPIARVRQAsVADyEEtVKKAREAWKIWAD
P49589 S305 Sugiyama CARS1 CARS KLVPEAVGDQKALQEGEGDLsIsADRLsEKRSPNDFALWKA
P49591 S394 Sugiyama SARS1 SARS SERS SKKLDLEAWFPGSGAFRELVsCSNCTDyQARRLRIRYGQTK
P49753 T118 Sugiyama ACOT2 PTE2 PTE2A ASLRDEKGALFQAHARyRADtLGELDLERAPALGGSFAGLE
P49815 S1798 SIGNOR TSC2 TSC4 AQTPAEPTPGyEVGQRKRLIssVEDFTEFV___________
P49841 S9 SIGNOR|PSP GSK3B ____________MSGRPRttsFAEsCKPVQQPsAFGsMKVS
P49959 T597 SIGNOR|PSP MRE11 HNGS1 MRE11A RGGRGQNSASRGGsQRGRADtGLETSTRSRNSKTAVSASRN
P50454 S139 Sugiyama SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14 SNSTARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEHS
P50549 S191 SIGNOR ETV1 ER81 PSQSIPDSSYPMDHRFRRQLsEPCNSFPPLPTMPREGRPMY
P50549 S216 SIGNOR ETV1 ER81 SFPPLPTMPREGRPMYQRQMsEPNIPFPPQGFKQEYHDPVY
P50552 T278 SIGNOR VASP SGGGGLMEEMNAMLARRRKAtQVGEKtPKDEsANQEEPEAR
P50991 S51 Sugiyama CCT4 CCTD SRB AQIRFsNISAAKAVADAIRtsLGPKGMDKMIQDGKGDVtIt
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51116 T610 Sugiyama FXR2 FMR1L2 RRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQsRQRPPLER
P51858 S107 Sugiyama HDGF HMG1L2 WEIENNPtVKASGYQSsQKKsCVEEPEPEPEAAEGDGDKKG
P51858 S83 Sugiyama HDGF HMG1L2 LFPyEEsKEKFGKPNKRKGFsEGLWEIENNPtVKASGYQSs
P52701 S309 PSP MSH6 GTBP GLNsPVKVARKRKRMVTGNGsLKRKSSRKETPSATKQAtsI
P52907 T217 Sugiyama CAPZA1 HYYEDGNVQLVSHKDVQDsLtVsNEAQtAKEFIKIIENAEN
P52948 S683 Sugiyama NUP98 ADAR2 IAKPIPQtPEsAGNKHsNsNsVDDtIVALNMRAALRNGLEG
P53365 S260 Sugiyama ARFIP2 POR1 TDLEELsLGPRDAGTRGRLEsAQATFQAHRDKYEKLRGDVA
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53396 S457 Sugiyama ACLY FLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMPQD
P53999 S12 Sugiyama SUB1 PC4 RPO2TC1 _________MPKSKELVsssssGsDsDsEVDKKLKRKKQVA
P53999 S9 Sugiyama SUB1 PC4 RPO2TC1 ____________MPKSKELVsssssGsDsDsEVDKKLKRKK
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P55036 T264 Sugiyama PSMD4 MCB1 AEAGIATTGtEDsDDALLKMtIsQQEFGRTGLPDLSSMTEE
P55060 S342 Sugiyama CSE1L CAS XPO2 ASVCERPHYKNLFEDQNtLtsICEKVIVPNMEFRAADEEAF
P55957 S76 Sugiyama BID ELQtDGNRssHsRLGRIEADsEsQEDIIRNIARHLAQVGDs
P57053 S37 Sugiyama H2BC12L H2BFS H2BS1 KAVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIss
P57053 S39 Sugiyama H2BC12L H2BFS H2BS1 VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P57053 Y38 Sugiyama H2BC12L H2BFS H2BS1 AVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssK
P57721 S82 Sugiyama PCBP3 PCBP3-OT1 PCBP3OT GKKGETVKKMREESGARINIsEGNCPERIVTITGPTDAIFK
P58876 S37 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
P58876 S39 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P58876 Y38 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD AVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60174 T217 Sugiyama TPI1 TPI VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60468 S49 Sugiyama SEC61B STVRQRKNASCGTRSAGRtTsAGTGGMWRFYTEDSPGLKVG
P60660 S30 Sugiyama MYL6 AEFKEAFQLFDRtGDGKILysQCGDVMRALGQNPtNAEVLK
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 T249 Sugiyama ACTB tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P60983 T27 Sugiyama GMFB VCDVAEDLVEKLRKFRFRKEtNNAAIIMKIDKDKRLVVLDE
P61024 S39 Sugiyama CKS1B CKS1 PNAS-143 PNAS-16 yRHVMLPKDIAKLVPKTHLMsEsEWRNLGVQQsQGWVHyMI
P61158 S406 Sugiyama ACTR3 ARP3 STPEFYQVCHTKKDyEEIGPsICRHNPVFGVMs________
P61247 S236 Sugiyama RPS3A FTE1 MFTL KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61353 S86 Sugiyama RPL27 SKIKSFVKVyNyNHLMPtRysVDIPLDKtVVNKDVFRDPAL
P61769 T106 Sugiyama B2M CDABP0092 HDCMA22P YYTEFTPTEKDEYACRVNHVtLsQPKIVKWDRDM_______
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981 T31 Sugiyama YWHAG ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P62081 T121 Sugiyama RPS7 LPKPTRKSRTKNKQKRPRsRtLtAVHDAILEDLVFPsEIVG
P62081 T123 Sugiyama RPS7 KPTRKSRTKNKQKRPRsRtLtAVHDAILEDLVFPsEIVGKR
P62241 S4 Sugiyama RPS8 OK/SW-cl.83 _________________MGIsRDNWHKRRKTGGKRKPYHKK
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62263 S137 Sugiyama RPS14 PRO2640 RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62269 S96 Sugiyama RPS18 D6S218E QYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLKK
P62269 Y95 Sugiyama RPS18 D6S218E RQYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLK
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62633 S47 Sugiyama CNBP RNF163 ZNF9 RGMRSRGRGGFTSDRGFQFVsSSLPDICYRCGESGHLAKDC
P62701 T247 Sugiyama RPS4X CCG2 RPS4 SCAR VIGKGNKPWIsLPRGKGIRLtIAEERDKRLAAKQSSG____
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 T251 Sugiyama ACTA2 ACTSA ACTVS GIG46 tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P62753 S235 SIGNOR|ELM|PSP RPS6 OK/SW-cl.2 KRMKEAKEKRQEQIAKRRRLssLRAstsKsEssQK______
P62753 S236 SIGNOR|ELM|PSP RPS6 OK/SW-cl.2 RMKEAKEKRQEQIAKRRRLssLRAstsKsEssQK_______
P62753 S240 SIGNOR|PSP RPS6 OK/SW-cl.2 AKEKRQEQIAKRRRLssLRAstsKsEssQK___________
P62753 S244 SIGNOR|PSP RPS6 OK/SW-cl.2 RQEQIAKRRRLssLRAstsKsEssQK_______________
P62753 T34 Sugiyama RPS6 OK/SW-cl.2 KLIEVDDERKLRtFyEKRMAtEVAADALGEEWKGYVVRIsG
P62805 S48 Sugiyama H4C1 H4/A H4FA HIST1H4A; H4C2 H4/I H4FI HIST1H4B; H4C3 H4/G H4FG HIST1H4C; H4C4 H4/B H4FB HIST1H4D; H4C5 H4/J H4FJ HIST1H4E; H4C6 H4/C H4FC HIST1H4F; H4C8 H4/H H4FH HIST1H4H; H4C9 H4/M H4FM HIST1H4I; H4C11 H4/E H4FE HIST1H4J; H4C12 H4/D H4FD HIST1H4K; H4C13 H4/K H4FK HIST1H4L; H4C14 H4/N H4F2 H4FN HIST2H4 HIST2H4A; H4C15 H4/O H4FO HIST2H4B; H4C16 H4-16 HIST4H4 QGItKPAIRRLARRGGVKRIsGLIyEETRGVLKVFLENVIR
P62807 S37 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI KAVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIss
P62807 S39 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA
P62807 Y38 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI AVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssK
P62899 T26 Sugiyama RPL31 KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62906 S64 Sugiyama RPL10A NEDD6 QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62906 T9 Sugiyama RPL10A NEDD6 ____________MSSKVsRDtLyEAVREVLHGNQRKRRKFL
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 S138 Sugiyama RPL8 EKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVI
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 T249 Sugiyama ACTG1 ACTG tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 T250 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P67809 S102 SIGNOR|Sugiyama YBX1 NSEP1 YB1 EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P67809 S209 Sugiyama YBX1 NSEP1 YB1 RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P67809 T108 Sugiyama YBX1 NSEP1 YB1 QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P67809 Y99 Sugiyama YBX1 NSEP1 YB1 DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 T251 Sugiyama ACTC1 ACTC tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68104 T432 Sugiyama EEF1A1 EEF1A EF1A LENG7 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 T251 Sugiyama ACTA1 ACTA tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68431 T59 Sugiyama H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J PHRyRPGtVALREIRRYQKstELLIRKLPFQRLVREIAQDF
P78362 S494 SIGNOR|PSP|Sugiyama SRPK2 GSPLTEQEESSPSHDRSRtVsAsstGDLPKAKTRAADLLVN
P78371 S143 Sugiyama CCT2 99D8.1 CCTB PQTIIAGWREATKAAREALLssAVDHGsDEVKFRQDLMNIA
P78371 S260 SIGNOR|PSP CCT2 99D8.1 CCTB ANtGMDtDKIKIFGsRVRVDstAKVAEIEHAEKEKMKEKVE
P83731 S7 Sugiyama RPL24 ______________MKVELCsFsGyKIYPGHGRRYARTDGK
P83731 S86 Sugiyama RPL24 EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098 S12 Sugiyama RPL19 _________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
P84243 S11 SIGNOR H3-3A H3.3A H3F3 H3F3A PP781; H3-3B H3.3B H3F3B __________MARtKQTARKstGGKAPRKQLATKAARKsAP
P84243 T59 Sugiyama H3-3A H3.3A H3F3 H3F3A PP781; H3-3B H3.3B H3F3B PHRyRPGtVALREIRRYQKstELLIRKLPFQRLVREIAQDF
P98175 S797 Sugiyama RBM10 DXS8237E GPATC9 GPATCH9 KIAA0122 HQQLsGLHKQNLEIHRRAHLsENELEALEKNDMEQMKYRDR
P99999 S48 Sugiyama CYCS CYC KTGPNLHGLFGRKtGQAPGysytAANKNKGIIWGEDTLMEY
Q02543 S123 Sugiyama RPL18A AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK
Q02543 T107 Sugiyama RPL18A RSGtHNMYREyRDLttAGAVtQCyRDMGARHRARAHsIQIM
Q02818 S193 Sugiyama NUCB1 NUC HEEFKRyEMLKEHERRRyLEsLGEEQRKEAERKLEEQQRRH
Q04837 S67 Sugiyama SSBP1 SSBP QVEGKNPVTIFSLATNEMWRsGDsEVyQLGDVsQKTTWHRI
Q04917 S145 Sugiyama YWHAH YWHA1 KMKGDYYRYLAEVASGEKKNsVVEAsEAAyKEAFEISKEQM
Q05195 S145 SIGNOR|PSP MXD1 MAD EQRHLKRQLEKLGIERIRMDsIGSTVSSERSDSDREEIDVD
Q05639 T432 Sugiyama EEF1A2 EEF1AL STN VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q05655 S302 Sugiyama PRKCD PKCD INQKLLAEALNQVtQRAsRRsDsAssEPVGIyQGFEKKTGV
Q06787 S500 PSP FMR1 GHGRRGPGYTSGTNSEAsNAsEtEsDHRDELsDWSLAPTEE
Q06830 S30 Sugiyama PRDX1 PAGA PAGB TDPX2 HPAPNFKAtAVMPDGQFKDIsLsDyKGKYVVFFFYPLDFTF
Q06830 T143 Sugiyama PRDX1 PAGA PAGB TDPX2 EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q07157 S1063 Sugiyama TJP1 ZO1 LPYVEKQAsRDLEQPtyRyEsssytDQFsRNYEHRLRYEDR
Q07864 S1297 Sugiyama POLE POLE1 KKWQLQARQRLARRKRQRLEsAEGVLRPGAIRDGPATGLGs
Q07866 S524 Sugiyama KLC1 KLC KNS2 QRVAEVLNDPENMEKRRsREsLNVDVVKYESGPDGGEEVSM
Q08211 S452 Sugiyama DHX9 DDX9 LKP NDH2 NDRAAECNIVVTQPRRIsAVsVAERVAFERGEEPGKSCGYS
Q08378 S465 Sugiyama GOLGA3 LSTKLQAQVECSHSSQQRQDsLsSEVDTLKQsCWDLERAMT
Q08945 S657 Sugiyama SSRP1 FACT80 MEKKSTPSRGsSSKSsSRQLsEsFKSKEFVssDEsssGENK
Q09161 S22 PSP|Sugiyama NCBP1 CBP80 NCBP SRRRHsDENDGGQPHKRRKtsDANEtEDHLEsLICKVGEKS
Q09161 S7 PSP NCBP1 CBP80 NCBP ______________MSRRRHsDENDGGQPHKRRKtsDANEt
Q09161 T21 PSP NCBP1 CBP80 NCBP MSRRRHsDENDGGQPHKRRKtsDANEtEDHLEsLICKVGEK
Q12792 S143 Sugiyama TWF1 PTK9 GTVKEDVSLHGYKKyLLsQssPAPLtAAEEELRQIKINEVQ
Q12824 S111 Sugiyama SMARCB1 BAF47 INI1 SNF5L1 LKASEVEEILDGNDEKYKAVsISTEPPTYLREQKAKRNsQW
Q12965 T939 Sugiyama MYO1E MYO1C SIGPGLPKNSRPTRRNttQNtGySsGtQNANyPVRAAPPPP
Q12965 Y941 Sugiyama MYO1E MYO1C GPGLPKNSRPTRRNttQNtGySsGtQNANyPVRAAPPPPGy
Q13247 S297 Sugiyama SRSF6 SFRS6 SRP55 RSRSPKENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsP
Q13247 S301 Sugiyama SRSF6 SFRS6 SRP55 PKENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKR
Q13286 S12 Sugiyama CLN3 BTS _________MGGCAGSRRRFsDsEGEEtVPEPRLPLLDHQG
Q13310 T191 Sugiyama PABPC4 APP1 PABP4 GRFKSRKEREAELGAKAKEFtNVyIKNFGEEVDDEsLKELF
Q13428 S85 Sugiyama TCOF1 AEEDAALQAKKTRVsDPIstsEssEEEEEAEAETAKAtPRL
Q13442 S19 Sugiyama PDAP1 HASPP28 __MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEEE
Q13442 T18 Sugiyama PDAP1 HASPP28 ___MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEE
Q13501 S24 Sugiyama SQSTM1 ORCA OSIL LTVKAYLLGKEDAAREIRRFsFCCsPEPEAEAEAAAGPGPC
Q13561 S83 Sugiyama DCTN2 DCTN50 GTKGLDFsDRIGKTKRtGyEsGEyEMLGEGLGVKETPQQKY
Q13765 S117 Sugiyama NACA HSD48 RKSKNILFVITKPDVYKSPAsDtyIVFGEAKIEDLsQQAQL
Q14152 S492 Sugiyama EIF3A EIF3S10 KIAA0139 VDAARHCDLQVRIDHTSRTLsFGsDLNyAtREDAPIGPHLQ
Q14152 S584 Sugiyama EIF3A EIF3S10 KIAA0139 EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14152 S895 Sugiyama EIF3A EIF3S10 KIAA0139 ERRLGDssLSRKDSRWGDRDsEGtWRKGPEADsEWRRGPPE
Q14152 S988 Sugiyama EIF3A EIF3S10 KIAA0139 PRRGPEEDRFsRRGADDDRPsWRNTDDDRPPRRIADEDRGN
Q14153 S167 Sugiyama FAM53B KIAA0140 SMP YsGGsVQRYSNGFSTMQRsssFSLPSRANVLssPCDQAGLH
Q14498 S337 Sugiyama RBM39 HCC1 RNPC2 AGRPMKVGHVTERtDAssAssFLDsDELERtGIDLGtTGRL
Q14566 S271 Sugiyama MCM6 VPDVSKLSTPGARAEtNsRVsGVDGyEtEGIRGLRALGVRD
Q14568 S50 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 MSLIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKL
Q14671 S709 Sugiyama PUM1 KIAA0099 PUMH1 LGGFGTAVANSNTGSGSRRDsLtGSsDLYKRTSSSLTPIGH
Q14697 S187 Sugiyama GANAB G2AN KIAA0088 LLsVNARGLLEFEHQRAPRVsQGsKDPAEGDGAQPEEtPRD
Q14697 S190 Sugiyama GANAB G2AN KIAA0088 VNARGLLEFEHQRAPRVsQGsKDPAEGDGAQPEEtPRDGDK
Q14978 S85 Sugiyama NOLC1 KIAA0035 NS5ATP13 ERKLQANGPVAKKAKKKAsssDsEDssEEEEEVQGPPAKKA
Q15020 S650 Sugiyama SART3 KIAA0156 TIP110 EKEWGDDEEEQPSKRRRVENsIPAAGETQNVEVAAGPAGKC
Q15084 S375 Sugiyama PDIA6 ERP5 P5 TXNDC7 GYPAMAAINARKMKFALLKGsFsEQGINEFLRELsFGRGst
Q15149 S4386 Sugiyama PLEC PLEC1 ItEFADMLsGNAGGFRsRsssVGssssyPIsPAVsRtQLAs
Q15365 S50 Sugiyama PCBP1 GKKGESVKRIREEsGARINIsEGNCPERIItLTGPTNAIFK
Q15366 S50 Sugiyama PCBP2 GKKGESVKKMREESGARINIsEGNCPERIITLAGPTNAIFK
Q15428 S153 Sugiyama SF3A2 SAP62 LFQIDYPEIAEGIMPRHRFMsAyEQRIEPPDRRWQYLLMAA
Q15633 S283 SIGNOR|PSP TARBP2 TRBP CTWDSLRNSVGEKILSLRsCsLGsLGALGPACCRVLSELSE
Q15633 S286 SIGNOR TARBP2 TRBP DSLRNSVGEKILSLRsCsLGsLGALGPACCRVLSELSEEQA
Q15642 S296 Sugiyama TRIP10 CIP4 STOT STP FARPGDVEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRS
Q15831 S428 SIGNOR|iPTMNet STK11 LKB1 PJS GRAPNPARKACSASSKIRRLsACKQQ_______________
Q16181 T318 Sugiyama SEPTIN7 CDC10 SEPT7 KDVTNNVHyENyRSRKLAAVtyNGVDNNKNKGQLtKsPLAQ
Q16204 S323 Sugiyama CCDC6 D10S170 TST1 RLQRKLQREMERREALCRQLsEsEssLEMDDERYFNEMsAQ
Q16513 S583 Sugiyama PKN2 PRK2 PRKCL2 VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs
Q16637 S49 PSP SMN1 SMN SMNT; SMN2 SMNC DDsDIWDDtALIKAYDKAVAsFKHALKNGDICETsGKPKtt
Q16695 T59 Sugiyama H3-4 H3FT HIST3H3 PHRyRPGtVALREIRRYQKstELLIRKLPFQRLMREIAQDF
Q16763 T152 Sugiyama UBE2S E2EPF OK/SW-cl.73 EAGRLLLENyEEyAARARLLtEIHGGAGGPSGRAEAGRALA
Q16778 S37 Sugiyama H2BC21 H2BFQ HIST2H2BE KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIss
Q16821 S46 SIGNOR PPP1R3A PP1G CEDEEVTFQPGFSPQPSRRGsDsSEDIYLDTPSSGTRRVsF
Q16873 S36 SIGNOR|PSP LTC4S VLLQAYFSLQVISARRAFRVsPPLtTGPPEFERVYRAQVNC
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q3B726 S316 Sugiyama POLR1F TWISTNB GsDssGyQsDHKKKKKKRKHsEEAEFtPPLKCsPKRKGKSN
Q3KQU3 S112 Sugiyama MAP7D1 KIAA1187 PARCC1 RPRC1 PP2464 KsRGPtPPAMGPRDARPPRRssQPsPtAVPAsDsPPtKQEV
Q4G0J3 S258 Sugiyama LARP7 HDCMA18P EENMDtsNtsIsKMKRsRPtsEGsDIEstEPQKQCSKKKKK
Q4G0J3 S300 Sugiyama LARP7 HDCMA18P DRVEAssLPEVRTGKRKRsssEDAEsLAPRSKVKKIIQKDI
Q53EL6 S457 PSP PDCD4 H731 GIISKQLRDLCPSRGRKRFVsEGDGGRLKPESY________
Q53EL6 S67 SIGNOR|PSP PDCD4 H731 AssINEARINAKAKRRLRKNssRDsGRGDsVsDsGsDALRS
Q562R1 T250 Sugiyama ACTBL2 RAAAssSPERsyELPDGQVItIGNERFRCPEAIFQPSFLGI
Q58FF7 S408 Sugiyama HSP90AB3P HSP90BC EPIDEYCVQQLKEFDGKsLVsVtKEGLELPEDEEEKKKMEE
Q58FF8 S308 Sugiyama HSP90AB2P HSP90BB YMTEPIDGYQLKEFDGKsLVsVtKEGLELPEDGEEKKRMEE
Q5QNW6 S37 Sugiyama H2BC18 HIST2H2BF KAVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q5QNW6 S39 Sugiyama H2BC18 HIST2H2BF VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q5QNW6 Y38 Sugiyama H2BC18 HIST2H2BF AVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
Q5T0N5 S488 Sugiyama FNBP1L C1orf39 TOCA1 NEAWLSEVEGKTGGRGDRRHssDINHLVtQGREsPEGsytD
Q5T1M5 S1162 Sugiyama FKBP15 KIAA0674 EAGstVAGAALRPsHHsQRssLsGDEEDELFKGATLKALRP
Q5TKA1 S177 Sugiyama LIN9 BARA TGS KLTRVEWGKIRRLMGKPRRCssAFFEEERSALKQKRQKIRL
Q5TKA1 S178 Sugiyama LIN9 BARA TGS LTRVEWGKIRRLMGKPRRCssAFFEEERSALKQKRQKIRLL
Q5VT52 S1070 Sugiyama RPRD2 KIAA0460 HSPC099 TATDQQQQEEHYRIETRVsssCLDLPDSTEEKGAPIETLGy
Q5VTB9 T368 Sugiyama RNF220 C1orf164 ENNNRFEEYEWCGQKRIRATtLLEGGFRGSGFIMCSGKENP
Q5VTE0 T432 Sugiyama EEF1A1P5 EEF1AL3 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q6DN03 S37 Sugiyama H2BC20P HIST2H2BC KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWC
Q6DRA6 S37 Sugiyama H2BC19P HIST2H2BD KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWC
Q6NXT2 T58 Sugiyama H3-5 H3F3C PHRyRPGtVALREIRRYQKstELLIRKLPFQRLVREIAQDF
Q6R327 T1135 SIGNOR|PSP RICTOR KIAA1999 PKGGKLSSESKTSNRRIRtLtEPsVDFNHsDDFtPISTVQK
Q6S8J3 T949 Sugiyama POTEE A26C1A POTE2 tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q71DI3 T59 Sugiyama H3C15 HIST2H3A; H3C14 H3F2 H3FM HIST2H3C; H3C13 HIST2H3D PHRyRPGtVALREIRRYQKstELLIRKLPFQRLVREIAQDF
Q71UM5 T74 Sugiyama RPS27L VLCVGCSTVLCQPTGGKARLtEGCsFRRKQH__________
Q7KZF4 S150 Sugiyama SND1 TDRD11 EGLAtRREGMRANNPEQNRLsECEEQAKAAKKGMWSEGNGS
Q7Z417 S652 Sugiyama NUFIP2 KIAA1321 PIG1 NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z417 T685 Sugiyama NUFIP2 KIAA1321 PIG1 HTKEMEsIWNLQKQDPKRIItyNEAMDsPDQ__________
Q7Z417 Y686 Sugiyama NUFIP2 KIAA1321 PIG1 TKEMEsIWNLQKQDPKRIItyNEAMDsPDQ___________
Q7Z4V5 S369 Sugiyama HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 EKERRRERADRGEAERGsGGssGDELREDDEPVKKRGRKGR
Q7Z4V5 S395 Sugiyama HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 REDDEPVKKRGRKGRGRGPPsssDsEPEAELEREAKKSAKK
Q7Z4V5 S397 Sugiyama HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 DDEPVKKRGRKGRGRGPPsssDsEPEAELEREAKKSAKKPQ
Q7Z4V5 S454 Sugiyama HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 VRPEEKQQAKPVKVERTRKRsEGFsMDRKVEKKKEPSVEEK
Q86T24 T606 PSP ZBTB33 KAISO ZNF348 LHPCRSLQIRQYAYLSDRSStIPAMKDDGIGYKVDTGKEPP
Q86TX2 T56 Sugiyama ACOT1 CTE1 ASLRDEKGALFQAHARyRADtLGELDLERAPALGGSFAGLE
Q86UE4 S494 Sugiyama MTDH AEG1 LYRIC PVNtsKTRPKQEKAFSLKtIstsDPAEVLVKNSQPIKTLPP
Q86V81 S145 Sugiyama ALYREF ALY BEF THOC4 LFAEFGtLKKAAVHYDRsGRsLGtADVHFERKADALKAMKQ
Q86VM9 S603 Sugiyama ZC3H18 NHN1 SSRSSRHSSFSGSRSRsRsFsssPsPsPtPsPHRPsIRTKG
Q86VM9 T395 Sugiyama ZC3H18 NHN1 EIERFWRGGQyENFRVQYtEtEPyHNYRERERERERENRQR
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q86X55 T39 Sugiyama CARM1 PRMT4 VPGGAGPCATVSVFPGARLLtIGDANGEIQRHAEQQALRLE
Q8IWW6 S215 Sugiyama ARHGAP12 QEQSCDSAGEGSERIHQDSEsGDELSSSsTEQIRAttPPNQ
Q8IWX8 S817 Sugiyama CHERP DAN26 SCAF6 QSRSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDS
Q8IWX8 T819 Sugiyama CHERP DAN26 SCAF6 RSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDSRL
Q8IX03 S947 SIGNOR WWC1 KIAA0869 KIBRA sKtFsPGPQSQYVCRLNRsDsDsSTLSKKPPFVRNSLERRS
Q8IX03 T929 SIGNOR WWC1 KIAA0869 KIBRA RVGtPsQGPFLRGSTIIRsKtFsPGPQSQYVCRLNRsDsDs
Q8N122 S719 SIGNOR RPTOR KIAA1303 RAPTOR TTEGGSLtPVRDsPCtPRLRsVssYGNIRAVATARSLNKSL
Q8N122 S721 SIGNOR RPTOR KIAA1303 RAPTOR EGGSLtPVRDsPCtPRLRsVssYGNIRAVATARSLNKSLQN
Q8N122 S722 SIGNOR RPTOR KIAA1303 RAPTOR GGSLtPVRDsPCtPRLRsVssYGNIRAVATARSLNKSLQNL
Q8N257 S37 Sugiyama H2BC26 H2BU1 HIST3H2BB KAVTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIss
Q8N6T3 S348 Sugiyama ARFGAP1 ARF1GAP FWETFGSAEPTKtRKsPssDsWtCADtstERRssDsWEVWG
Q8NE71 S285 Sugiyama ABCF1 ABC50 MEYERQVASLKAANAAENDFsVsQAEMSsRQAMLENASDIK
Q8NEJ9 S202 Sugiyama NGDN C14orf120 DETEAEREKKRLERAKRRALsSsVIRELKEQYsDAPEEIRD
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8TB45 S286 SIGNOR|PSP DEPTOR DEPDC6 PsKEIKIVSAVRRssMssCGssGyFsssPtLsssPPVLCNP
Q8TB45 S287 SIGNOR|PSP DEPTOR DEPDC6 sKEIKIVSAVRRssMssCGssGyFsssPtLsssPPVLCNPK
Q8TB45 S291 SIGNOR|PSP DEPTOR DEPDC6 KIVSAVRRssMssCGssGyFsssPtLsssPPVLCNPKSVLK
Q8TD19 T333 Sugiyama NEK9 KIAA1995 NEK8 NERCC REMEEKVTLLNAPTKRPRsstVtEAPIAVVTSRTSEVYVWG
Q8TD47 T247 Sugiyama RPS4Y2 RPS4Y2P VIGNGNKPWISLPRGKGIRLtIAEERDKRLAAKQSSG____
Q8TEQ6 S852 Sugiyama GEMIN5 PKEKPETLIKKRKARsLLPLstsLDHRSKEELHQDCLVLAT
Q8TEW0 S837 Sugiyama PARD3 PAR3 PAR3A AFQREGFGRQsMsEKRtKQFsDAsQLDFVKTRKsKsMDLGI
Q8TEW0 S962 Sugiyama PARD3 PAR3 PAR3A DEGMEtLEEDTEESSRsGREsVstAsDQPsHsLERQMNGNQ
Q8TEW0 Y719 Sugiyama PARD3 PAR3 PAR3A PELPIETALDDRERRIsHsLysGIEGLDEsPsRNAALsRIM
Q8WUA7 S150 Sugiyama TBC1D22A C22orf4 PPsPPsGDLRLVKsVsEsHtsCPAESASDAAPLQRsQsLPH
Q8WWI1 S706 Sugiyama LMO7 FBX20 FBXO20 KIAA0858 RLMVERLFQKIYGENGsKsMsDVsAEDVQNLRQLRYEEMQK
Q92519 S83 SIGNOR|PSP TRIB2 TRB2 KYLLLEPLEGDHVFRAVHLHsGEELVCKVFDISCYQESLAP
Q92570 S376 SIGNOR NR4A3 CHN CSMF MINOR NOR1 TEC GMVKEVVRTDsLKGRRGRLPsKPKsPLQQEPsQPsPPsPPI
Q92597 S330 Sugiyama NDRG1 CAP43 DRG1 RTP QGMGYMPsAsMtRLMRsRtAsGssVtsLDGtRsRsHtSEGT
Q92614 S1465 Sugiyama MYO18A CD245 KIAA0216 MYSPDZ TIAF1 HLEGQQVRNHELEKKQRRFDsELSQAHEEAQREKLQREKLQ
Q92934 S118 SIGNOR BAD BBC6 BCL2L8 RsAPPNLWAAQRYGRELRRMsDEFVDsFKKGLPRPKsAGtA
Q92934 S153 SIGNOR BAD BBC6 BCL2L8 KsAGtATQMRQSSSWTRVFQsWWDRNLGRGSSAPSQ_____
Q92934 S75 SIGNOR BAD BBC6 BCL2L8 PTSSSHHGGAGAVEIRsRHssyPAGtEDDEGMGEEPsPFRG
Q92945 S395 PSP KHSRP FUBP2 PPDRCEHAARIINDLLQSLRsGPPGPPGGPGMPPGGRGRGR
Q93079 S37 Sugiyama H2BC9 H2BFJ HIST1H2BH KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q93079 S39 Sugiyama H2BC9 H2BFJ HIST1H2BH VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q93079 Y38 Sugiyama H2BC9 H2BFJ HIST1H2BH AVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
Q969S3 S38 Sugiyama ZNF622 ZPR9 MQRAHYKTDWHRYNLRRKVAsMAPVTAEGFQERVRAQRAVA
Q96CW6 T177 Sugiyama SLC7A6OS KTSDPDVILCNsVELIRERLtVSEDGPGVRRQEEQKHDDYV
Q96DV4 S129 Sugiyama MRPL38 HSPC262 AIQELRANVEEERAARLRTAsVPLDAVRAEWERTCGPYHKQ
Q96G46 T240 Sugiyama DUS3L KREVRFERAEQALRRFsQGPtPAAAVPEGTAAEGAPRQENC
Q96GM8 S420 Sugiyama TOE1 KNDLEMGIKAARPEIADRATsEVPGsQAsPNPVPGDGLHRA
Q96GM8 S425 Sugiyama TOE1 MGIKAARPEIADRATsEVPGsQAsPNPVPGDGLHRAGFDAF
Q96HE7 S143 Sugiyama ERO1A ERO1L UNQ434/PRO865 EANNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSD
Q96JP5 S177 Sugiyama ZFP91 ZNF757 FKSG11 TSVSRHRDTENTRSSRSKTGsLQLICKSEPNTDQLDYDVGE
Q96KQ7 S232 Sugiyama EHMT2 BAT8 C6orf30 G9A KMT1C NG36 DDVHsLGKVTSDLAKRRKLNsGGGLsEELGsARRsGEVTLt
Q96PZ0 S53 Sugiyama PUS7 KIAA1897 QKLsECsLTKGQDGLQNDFLsISEDVPRPPDtVStGKGGKN
Q96RU3 S497 Sugiyama FNBP1 FBP17 KIAA0554 AWLAEVEGRLPARSEQARRQsGLyDSQNPPTVNNCAQDREs
Q99426 T108 Sugiyama TBCB CG22 CKAP1 IDHsGARLGEyEDVSRVEKytIsQEAyDQRQDtVRSFLKRs
Q99543 S47 Sugiyama DNAJC2 MPHOSPH11 MPP11 ZRF1 QVEPVGRWFEAFVKRRNRNAsAsFQELEDKKELsEEsEDEE
Q99543 S49 Sugiyama DNAJC2 MPHOSPH11 MPP11 ZRF1 EPVGRWFEAFVKRRNRNAsAsFQELEDKKELsEEsEDEELQ
Q99584 S32 Sugiyama S100A13 SIETVVTTFFTFARQEGRKDsLsVNEFKELVTQQLPHLLKD
Q99733 S125 Sugiyama NAP1L4 NAP2 KRREFItGDVEPtDAEsEWHsENEEEEKLAGDMKSKVVVTE
Q99877 S37 Sugiyama H2BC15 H2BFD HIST1H2BN KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99877 S39 Sugiyama H2BC15 H2BFD HIST1H2BN VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99877 Y38 Sugiyama H2BC15 H2BFD HIST1H2BN AVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
Q99879 S37 Sugiyama H2BC14 H2BFE HIST1H2BM KAINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99879 S39 Sugiyama H2BC14 H2BFE HIST1H2BM INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99879 Y38 Sugiyama H2BC14 H2BFE HIST1H2BM AINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
Q99880 S37 Sugiyama H2BC13 H2BFC HIST1H2BL KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99880 S39 Sugiyama H2BC13 H2BFC HIST1H2BL VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99880 Y38 Sugiyama H2BC13 H2BFC HIST1H2BL AVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
Q9BQ52 S215 Sugiyama ELAC2 HPC2 QPWQsPERPLsRLsPERssDsEsNENEPHLPHGVsQRRGVR
Q9BQG0 S1186 Sugiyama MYBBP1A P160 sKKRKKKGFLPETKKRKKRKsEDGtPAEDGtPAATGGsQPP
Q9BRS2 S498 Sugiyama RIOK1 RIO1 GVQKVPALLENQVEERtCsDsEDIGssECsDtDSEEQGDHA
Q9BRS2 S503 Sugiyama RIOK1 RIO1 PALLENQVEERtCsDsEDIGssECsDtDSEEQGDHARPKKH
Q9BRS2 S504 Sugiyama RIOK1 RIO1 ALLENQVEERtCsDsEDIGssECsDtDSEEQGDHARPKKHT
Q9BVJ6 S29 Sugiyama UTP14A SDCCAG16 sLLALsQQEELADLPKDyLLsEsEDEGDNDGERKHQKLLEA
Q9BVS4 S335 Sugiyama RIOK2 RIO2 LLHPLGPDDKNIETKEGsEFsFsDGEVAEKAEVyGsENEsE
Q9BVS4 S412 Sugiyama RIOK2 RIO2 EMTEFNQALEEIKGQVVENNsVTEFsEEKNRTENYNRQDGQ
Q9BY44 S524 Sugiyama EIF2A CDA02 MSTP004 MSTP089 DKsPDLAPtPAPQstPRNtVsQsIsGDPEIDKKIKNLKKKL
Q9BY44 S526 Sugiyama EIF2A CDA02 MSTP004 MSTP089 sPDLAPtPAPQstPRNtVsQsIsGDPEIDKKIKNLKKKLKA
Q9BY44 T522 Sugiyama EIF2A CDA02 MSTP004 MSTP089 RsDKsPDLAPtPAPQstPRNtVsQsIsGDPEIDKKIKNLKK
Q9BY77 S383 SIGNOR|ELM|PSP POLDIP3 KIAA1649 PDIP46 LRLSDsPsMKKESELPRRVNsAsssNPPAEVDPDTILKALF
Q9BY77 S385 SIGNOR|PSP POLDIP3 KIAA1649 PDIP46 LSDsPsMKKESELPRRVNsAsssNPPAEVDPDTILKALFKs
Q9BYV9 S520 PSP BACH2 CPVPIKVCPRsPPLETRTRTssSCSSYSYAEDGSGGSPCSL
Q9BYV9 S521 PSP BACH2 PVPIKVCPRsPPLETRTRTssSCSSYSYAEDGSGGSPCSLP
Q9BYX2 S915 Sugiyama TBC1D2 PARIS1 PP8997 TBC1D2A ELEQLKAEyLERRASRRRAVsEGCAsEDEVEGEA_______
Q9BYX2 S920 Sugiyama TBC1D2 PARIS1 PP8997 TBC1D2A KAEyLERRASRRRAVsEGCAsEDEVEGEA____________
Q9BYX7 T249 Sugiyama POTEKP ACTBL3 FKSG30 MAASSSSVEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q9GZR1 T1092 Sugiyama SENP6 KIAA0797 SSP1 SUSP1 FKSG6 RNIILKLQEDQSKEKRKHKDtYSTEAPLGEGTEQYVNSIsD
Q9GZT9 S125 PSP EGLN1 C1orf12 PNAS-118 PNAS-137 GDAAKGKVKAKPPADPAAAAsPCRAAAGGQGsAVAAEAEPG
Q9H0H5 S206 Sugiyama RACGAP1 KIAA1478 MGCRACGAP tsRQFVDGPPGPVKKtRsIGsAVDQGNEsIVAKTTVTVPND
Q9H2G2 S1210 Sugiyama SLK KIAA0204 STK2 EEEFARKLQEQEVFFKMTGEsECLNPStQsRISKFyPIPsL
Q9H2U2 S313 Sugiyama PPA2 HSPC124 VQISDSPFRCtQEEARsLVEsVsssPNKEsNEEEQVWHFLG
Q9H3D4 S477 SIGNOR TP63 KET P63 P73H P73L TP73L ssYGNssPPLNKMNSMNKLPsVsQLINPQQRNALtPTTIPD
Q9H3D4 S560 SIGNOR|PSP TP63 KET P63 P73H P73L TP73L PPPYPTDCSIVSFLARLGCSsCLDYFTTQGLTTIYQIEHYS
Q9H3D4 T491 SIGNOR TP63 KET P63 P73H P73L TP73L SMNKLPsVsQLINPQQRNALtPTTIPDGMGANIPMMGTHMP
Q9H3N1 S226 Sugiyama TMX1 TMX TXNDC TXNDC1 PSEC0085 UNQ235/PRO268 LCPSKRRRPQPYPYPSKKLLsEsAQPLKKVEEEQEADEEDV
Q9H3Q1 S311 Sugiyama CDC42EP4 BORG4 CEP4 PsPGsARSMGSHTTRDSSsLssCtsGILEERsPAFRGPDRA
Q9H6H4 S152 Sugiyama REEP4 C8orf20 PP432 AAVQAATKSQGALAGRLRsFsMQDLRSISDAPAPAyHDPLy
Q9H6Z4 S126 SIGNOR|Sugiyama RANBP3 EDsDREDGNyCPPVKRERtssLtQFPPSQSEERSSGFRLKP
Q9H788 S315 Sugiyama SH2D4A PPP1R38 SH2A LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9H7D7 S123 Sugiyama WDR26 CDW2 MIP2 PRO0852 SSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLNQT
Q9H7E9 T40 Sugiyama C8orf33 PCAsRGARLPGPVsSARNPstVCLCPEQPTCSNADSRAHPL
Q9NP61 S367 Sugiyama ARFGAP3 ARFGAP1 DsyFTSSSSYFDEPVELRsssFssWDDssDSyWKKETSKDT
Q9NPG3 S173 Sugiyama UBN1 LTTKYGGFYINSGTLQFRQAsEsEDDFIKEKKKKSPKKRKL
Q9NPI1 S336 Sugiyama BRD7 BP75 CELTIX1 EQLDRIVKESGGKLTRRLVNsQCEFERRKPDGTTTLGLLHP
Q9NR28 S230 Sugiyama DIABLO SMAC EAQIEELRQKTQEEGEERAEsEQEAyLRED___________
Q9NR30 S706 Sugiyama DDX21 PTASVTEIQEKWHDSRRWQLsVATEQPELEGPREGYGGFRG
Q9NR45 S253 Sugiyama NANS SAS KVLERHITLDKTWKGsDHsAsLEPGELAELVRSVRLVERAL
Q9NRA8 S353 Sugiyama EIF4ENIF1 SASRFSRWFSNPsRsGsRsssLGstPHEELERLAGLEQAIL
Q9NTI5 S1257 Sugiyama PDS5B APRIN AS3 KIAA0979 LVQEQKPKGSQRSRKRGHtAsEsDEQQWPEEKRLKEDILEN
Q9NVN8 S87 Sugiyama GNL3L MREKQQAAREQERQKRRTIEsYCQDVLRRQEEFEHKEEVLQ
Q9NYF8 S196 Sugiyama BCLAF1 BTF KIAA0164 EsPLKsKsQEEPKDtFEHDPsEsIDEFNKssAtsGDIWPGL
Q9NZN5 S1288 Sugiyama ARHGEF12 KIAA0382 LARG GLTEKsVQEDWQHFPRyRtAsQGPQtDSVIQNSENIKAyHs
Q9NZN5 T1293 Sugiyama ARHGEF12 KIAA0382 LARG sVQEDWQHFPRyRtAsQGPQtDSVIQNSENIKAyHsGEGHM
Q9NZN5 Y1284 Sugiyama ARHGEF12 KIAA0382 LARG VQQLGLTEKsVQEDWQHFPRyRtAsQGPQtDSVIQNSENIK
Q9P258 S45 Sugiyama RCC2 KIAA1470 TD60 PRKRGGPAGRKRERPERCssssGGGssGDEDGLELDGAPGG
Q9UBP6 S27 SIGNOR|Sugiyama METTL1 C12orf1 NVAGAEAPPPQKRYYRQRAHsNPMADHTLRYPVKPEEMDWS
Q9UBT2 T156 Sugiyama UBA2 SAE2 UBLE1B HRIHFB2115 LIESGTAGYLGQVTTIKKGVtECyECHPKPTQRTFPGCtIR
Q9UGV2 S331 Sugiyama NDRG3 QGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQ
Q9UGV2 S333 Sugiyama NDRG3 MGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsD
Q9UGV2 S334 Sugiyama NDRG3 GYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsDG
Q9UGV2 S335 Sugiyama NDRG3 YIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsDGt
Q9UGV2 T332 Sugiyama NDRG3 GMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQs
Q9UHI6 T748 Sugiyama DDX20 DP103 GEMIN3 SQRAKQSRRNLPRRSsFRLQtEAQEDDWyDCHREIRLSFSD
Q9UHI8 S607 Sugiyama ADAMTS1 KIAA1346 METH1 DNPVPKNGGKYCEGKRVRYRsCNLEDCPDNNGKTFREEQCE
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UKV3 S240 Sugiyama ACIN1 ACINUS KIAA0670 KPRKGERRSSRVRQARAAKLsEGsQPAEEEEDQEtPsRNLR
Q9UKV3 S990 Sugiyama ACIN1 ACINUS KIAA0670 KVTLGDtLtRRsIsQQKsGVsITIDDPVRtAQVPsPPRGKI
Q9UN36 S332 PSP|Sugiyama NDRG2 KIAA1248 SYLD QGMGYMASSCMTRLsRsRtAsLtsAAsVDGNRsRsRtLsQs
Q9UN36 S350 PSP NDRG2 KIAA1248 SYLD tAsLtsAAsVDGNRsRsRtLsQssEsGtLsSGPPGHTMEVS
Q9UPQ0 S377 Sugiyama LIMCH1 KIAA1102 LREEDDKWQDDLARWKSRRRsVsQDLIKKEEERKKMEKLLA
Q9UQ35 S1541 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDs
Q9UQ35 S1542 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDss
Q9UQ35 S1653 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 PRRSRSGSSSKGRGPsPEGssstEssPEHPPKSRTARRGsR
Q9UQ35 S2692 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2I7 S307 Sugiyama PIKFYVE KIAA0981 PIP5K3 TRLVSVQEDAGKsPARNRsAsItNLsLDRsGsPMVPSYEts
Q9Y2T7 S137 Sugiyama YBX2 CSDA3 MSY2 EDVFVHQtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEA
Q9Y2T7 T143 Sugiyama YBX2 CSDA3 MSY2 QtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEATNVTGP
Q9Y2V2 S52 SIGNOR CARHSP1 sPLRGNVVPsPLPtRRtRtFsAtVRASQGPVYKGVCKCFCR
Q9Y3U8 S91 Sugiyama RPL36 KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Q9Y450 S67 Sugiyama HBS1L HBS1 KIAA1038 KPsVEPVEEyDyEDLKEssNsVsNHQLSGFDQARLYsCLDH
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 3.340231e-10 9.476 0 0
Cell Cycle, Mitotic R-HSA-69278 9.945614e-09 8.002 0 0
Chromatin modifying enzymes R-HSA-3247509 2.738343e-08 7.563 0 0
Cellular Senescence R-HSA-2559583 2.579224e-08 7.589 0 0
Signal Transduction R-HSA-162582 3.270170e-08 7.485 1 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.959380e-08 7.402 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.320673e-07 6.879 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.311426e-07 6.882 0 0
Chromatin organization R-HSA-4839726 2.281135e-07 6.642 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 4.416209e-07 6.355 0 0
Estrogen-dependent gene expression R-HSA-9018519 4.799441e-07 6.319 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 6.998792e-07 6.155 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 7.271205e-07 6.138 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 8.312114e-07 6.080 0 0
Cell Cycle Checkpoints R-HSA-69620 1.414288e-06 5.849 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 2.795749e-06 5.554 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.631862e-06 5.580 0 0
Diseases of programmed cell death R-HSA-9645723 2.968960e-06 5.527 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.476155e-06 5.349 0 0
Meiotic synapsis R-HSA-1221632 6.380114e-06 5.195 0 0
Apoptotic execution phase R-HSA-75153 8.976547e-06 5.047 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.071807e-05 4.970 0 0
NRAGE signals death through JNK R-HSA-193648 1.378513e-05 4.861 0 0
Mitotic Prophase R-HSA-68875 1.430746e-05 4.844 0 0
HATs acetylate histones R-HSA-3214847 1.516697e-05 4.819 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.641083e-05 4.785 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.045364e-05 4.689 0 0
Death Receptor Signaling R-HSA-73887 2.077156e-05 4.683 0 0
Meiosis R-HSA-1500620 2.170025e-05 4.664 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 2.429159e-05 4.615 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.826450e-05 4.549 0 0
M Phase R-HSA-68886 2.864663e-05 4.543 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 3.040383e-05 4.517 0 0
ESR-mediated signaling R-HSA-8939211 3.530935e-05 4.452 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 3.547644e-05 4.450 0 0
DNA methylation R-HSA-5334118 3.813632e-05 4.419 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 3.926286e-05 4.406 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 3.969856e-05 4.401 0 0
PRC2 methylates histones and DNA R-HSA-212300 3.998708e-05 4.398 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 4.911045e-05 4.309 0 0
Axon guidance R-HSA-422475 5.204736e-05 4.284 0 0
DNA Double Strand Break Response R-HSA-5693606 6.076354e-05 4.216 0 0
Packaging Of Telomere Ends R-HSA-171306 6.987279e-05 4.156 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 6.987279e-05 4.156 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 7.327778e-05 4.135 0 0
G2/M DNA damage checkpoint R-HSA-69473 9.669940e-05 4.015 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.779761e-05 4.010 0 0
Defective pyroptosis R-HSA-9710421 1.120965e-04 3.950 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.199412e-04 3.921 0 0
Nervous system development R-HSA-9675108 1.190764e-04 3.924 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.262484e-04 3.899 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.340242e-04 3.873 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.383114e-04 3.859 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.475479e-04 3.831 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.547574e-04 3.810 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.651605e-04 3.782 0 0
RNA Polymerase II Transcription R-HSA-73857 1.683035e-04 3.774 0 0
Nucleosome assembly R-HSA-774815 1.811336e-04 3.742 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.811336e-04 3.742 0 0
Regulation of TP53 Activity R-HSA-5633007 1.741788e-04 3.759 0 0
Reproduction R-HSA-1474165 1.754034e-04 3.756 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.909491e-04 3.719 0 0
Rab regulation of trafficking R-HSA-9007101 1.924012e-04 3.716 0 0
G alpha (12/13) signalling events R-HSA-416482 2.006810e-04 3.697 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.208849e-04 3.656 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 2.270984e-04 3.644 0 0
Meiotic recombination R-HSA-912446 2.544522e-04 3.594 0 0
Gene expression (Transcription) R-HSA-74160 2.555376e-04 3.593 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.691378e-04 3.570 0 0
Signaling by Hippo R-HSA-2028269 2.821169e-04 3.550 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.344770e-04 3.476 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.487439e-04 3.457 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.102661e-04 3.387 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 4.303607e-04 3.366 0 0
Cleavage of the damaged purine R-HSA-110331 4.843446e-04 3.315 0 0
DNA Double-Strand Break Repair R-HSA-5693532 5.116784e-04 3.291 0 0
Intracellular signaling by second messengers R-HSA-9006925 5.105117e-04 3.292 0 0
Signaling by ROBO receptors R-HSA-376176 5.416962e-04 3.266 0 0
HDACs deacetylate histones R-HSA-3214815 5.720474e-04 3.243 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 5.987593e-04 3.223 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 5.715688e-04 3.243 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 5.993314e-04 3.222 0 0
Depurination R-HSA-73927 6.130192e-04 3.213 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 8.530836e-04 3.069 0 0
Generic Transcription Pathway R-HSA-212436 8.856222e-04 3.053 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.020714e-03 2.991 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.191153e-03 2.924 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.187620e-03 2.925 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.165966e-03 2.933 0 0
Activation of RAC1 R-HSA-428540 1.232468e-03 2.909 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 1.341265e-03 2.872 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.484695e-03 2.828 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.466050e-03 2.834 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.409573e-03 2.851 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 1.551045e-03 2.809 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.561027e-03 2.807 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.652757e-03 2.782 0 0
Homology Directed Repair R-HSA-5693538 1.664266e-03 2.779 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.765703e-03 2.753 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.782604e-03 2.749 0 0
Depyrimidination R-HSA-73928 1.782604e-03 2.749 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.816699e-03 2.741 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.924557e-03 2.716 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.993577e-03 2.700 0 0
Programmed Cell Death R-HSA-5357801 2.022890e-03 2.694 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.310775e-03 2.636 0 0
Signaling by VEGF R-HSA-194138 2.197074e-03 2.658 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.177200e-03 2.662 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 2.316351e-03 2.635 0 0
Ub-specific processing proteases R-HSA-5689880 2.400181e-03 2.620 0 0
Signaling by WNT R-HSA-195721 2.577086e-03 2.589 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.684441e-03 2.571 0 0
G2/M Checkpoints R-HSA-69481 2.720956e-03 2.565 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.154594e-03 2.501 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.154594e-03 2.501 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.482551e-03 2.458 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 3.409296e-03 2.467 0 0
Deubiquitination R-HSA-5688426 3.832871e-03 2.416 0 0
Apoptosis R-HSA-109581 3.900432e-03 2.409 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 3.961263e-03 2.402 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 3.961263e-03 2.402 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 3.961263e-03 2.402 0 0
Chromosome Maintenance R-HSA-73886 4.231961e-03 2.373 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 4.382957e-03 2.358 0 0
RNA Polymerase I Transcription R-HSA-73864 4.456137e-03 2.351 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.838138e-03 2.315 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 4.753838e-03 2.323 0 0
Mitotic Prometaphase R-HSA-68877 4.846550e-03 2.315 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 4.921302e-03 2.308 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 5.106411e-03 2.292 0 0
Cell-extracellular matrix interactions R-HSA-446353 5.116844e-03 2.291 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 5.183338e-03 2.285 0 0
Mitotic G2-G2/M phases R-HSA-453274 5.227251e-03 2.282 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 5.636737e-03 2.249 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 5.834650e-03 2.234 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 5.757321e-03 2.240 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 6.037308e-03 2.219 0 0
Germ layer formation at gastrulation R-HSA-9754189 6.417195e-03 2.193 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 6.600501e-03 2.180 0 0
Diseases of mitotic cell cycle R-HSA-9675126 6.914920e-03 2.160 0 0
PIP3 activates AKT signaling R-HSA-1257604 7.090143e-03 2.149 0 0
DAG and IP3 signaling R-HSA-1489509 7.256943e-03 2.139 0 0
FLT3 Signaling R-HSA-9607240 7.265082e-03 2.139 0 0
CREB phosphorylation R-HSA-199920 8.366540e-03 2.077 0 0
mRNA Splicing - Major Pathway R-HSA-72163 8.301979e-03 2.081 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 8.239827e-03 2.084 0 0
Cell junction organization R-HSA-446728 7.857631e-03 2.105 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 8.170063e-03 2.088 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 8.557493e-03 2.068 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 9.570631e-03 2.019 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 9.570631e-03 2.019 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 9.254190e-03 2.034 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 9.323858e-03 2.030 0 0
mRNA 3'-end processing R-HSA-72187 9.647623e-03 2.016 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 9.690502e-03 2.014 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 9.690502e-03 2.014 0 0
DARPP-32 events R-HSA-180024 9.760086e-03 2.011 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.091634e-02 1.962 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.091634e-02 1.962 0 0
G2/M Transition R-HSA-69275 1.122654e-02 1.950 0 0
HDMs demethylate histones R-HSA-3214842 1.131933e-02 1.946 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.131933e-02 1.946 0 0
TBC/RABGAPs R-HSA-8854214 1.179890e-02 1.928 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.181225e-02 1.928 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.247289e-02 1.904 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.247289e-02 1.904 0 0
Regulation of PTEN localization R-HSA-8948747 1.270229e-02 1.896 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.330102e-02 1.876 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.386881e-02 1.858 0 0
TRP channels R-HSA-3295583 1.381900e-02 1.860 0 0
RAB geranylgeranylation R-HSA-8873719 1.390133e-02 1.857 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.422601e-02 1.847 0 0
Post NMDA receptor activation events R-HSA-438064 1.443631e-02 1.841 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.490018e-02 1.827 0 0
EPH-Ephrin signaling R-HSA-2682334 1.492530e-02 1.826 0 0
Telomere Maintenance R-HSA-157579 1.534212e-02 1.814 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.616030e-02 1.792 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 1.616030e-02 1.792 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 1.616030e-02 1.792 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.576603e-02 1.802 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.653128e-02 1.782 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.750474e-02 1.757 0 0
G0 and Early G1 R-HSA-1538133 1.688408e-02 1.773 0 0
Ion homeostasis R-HSA-5578775 1.663152e-02 1.779 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.750474e-02 1.757 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.616030e-02 1.792 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.649797e-02 1.783 0 0
Calmodulin induced events R-HSA-111933 1.674290e-02 1.776 0 0
CaM pathway R-HSA-111997 1.674290e-02 1.776 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.671028e-02 1.777 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.638566e-02 1.786 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.638566e-02 1.786 0 0
Cell-Cell communication R-HSA-1500931 1.648300e-02 1.783 0 0
mRNA Splicing R-HSA-72172 1.783009e-02 1.749 0 0
Type I hemidesmosome assembly R-HSA-446107 1.834806e-02 1.736 0 0
FOXO-mediated transcription R-HSA-9614085 1.858201e-02 1.731 0 0
Rap1 signalling R-HSA-392517 1.859311e-02 1.731 0 0
Cardiogenesis R-HSA-9733709 1.995835e-02 1.700 0 0
Semaphorin interactions R-HSA-373755 2.007276e-02 1.697 0 0
Recycling pathway of L1 R-HSA-437239 2.094924e-02 1.679 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.114451e-02 1.675 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 2.122574e-02 1.673 0 0
Neurodegenerative Diseases R-HSA-8863678 2.372352e-02 1.625 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.372352e-02 1.625 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.483025e-02 1.605 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 2.483025e-02 1.605 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 2.483025e-02 1.605 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.483025e-02 1.605 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 2.483025e-02 1.605 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.631095e-02 1.580 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 3.054769e-02 1.515 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 2.803956e-02 1.552 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 2.803956e-02 1.552 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 3.054769e-02 1.515 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.903754e-02 1.537 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.909615e-02 1.536 0 0
Kinesins R-HSA-983189 2.698794e-02 1.569 0 0
PLC beta mediated events R-HSA-112043 3.020005e-02 1.520 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 3.091180e-02 1.510 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 3.172931e-02 1.499 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 3.221060e-02 1.492 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.221060e-02 1.492 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.265729e-02 1.486 0 0
Specification of primordial germ cells R-HSA-9827857 3.300355e-02 1.481 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.344133e-02 1.476 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.584331e-02 1.446 0 0
G1/S-Specific Transcription R-HSA-69205 3.644967e-02 1.438 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.644967e-02 1.438 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 3.694808e-02 1.432 0 0
Cellular responses to stimuli R-HSA-8953897 3.730167e-02 1.428 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 3.745713e-02 1.426 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 3.745713e-02 1.426 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 3.854643e-02 1.414 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 3.907330e-02 1.408 0 0
Centrosome maturation R-HSA-380287 3.916944e-02 1.407 0 0
DNA Repair R-HSA-73894 3.919281e-02 1.407 0 0
Amyloid fiber formation R-HSA-977225 3.970368e-02 1.401 0 0
MITF-M-dependent gene expression R-HSA-9856651 3.976522e-02 1.400 0 0
PKA activation R-HSA-163615 4.026186e-02 1.395 0 0
PKA activation in glucagon signalling R-HSA-164378 4.026186e-02 1.395 0 0
Polo-like kinase mediated events R-HSA-156711 4.026186e-02 1.395 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 4.026186e-02 1.395 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 4.027716e-02 1.395 0 0
Regulation of necroptotic cell death R-HSA-5675482 4.403339e-02 1.356 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 4.403339e-02 1.356 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.597825e-02 1.337 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 4.753421e-02 1.323 0 0
Opioid Signalling R-HSA-111885 4.721152e-02 1.326 0 0
MTOR signalling R-HSA-165159 4.456239e-02 1.351 1 0
Transcriptional regulation by RUNX3 R-HSA-8878159 4.380229e-02 1.359 0 0
Ca-dependent events R-HSA-111996 4.456239e-02 1.351 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 4.713851e-02 1.327 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 4.417996e-02 1.355 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.771124e-02 1.321 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 4.776520e-02 1.321 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 4.776520e-02 1.321 0 0
MECP2 regulates transcription factors R-HSA-9022707 4.926218e-02 1.307 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.971776e-02 1.303 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.971776e-02 1.303 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.971776e-02 1.303 0 0
Dopamine receptors R-HSA-390651 4.971776e-02 1.303 0 0
Membrane Trafficking R-HSA-199991 5.099539e-02 1.292 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 5.119885e-02 1.291 0 0
Cardiac conduction R-HSA-5576891 5.146407e-02 1.288 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 5.385377e-02 1.269 0 0
G-protein mediated events R-HSA-112040 5.560607e-02 1.255 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 5.586755e-02 1.253 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 5.609741e-02 1.251 0 0
Base Excision Repair R-HSA-73884 5.609741e-02 1.251 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 5.624773e-02 1.250 0 0
Signaling by AMER1 mutants R-HSA-4839748 5.624773e-02 1.250 0 0
Signaling by GSK3beta mutants R-HSA-5339716 5.624773e-02 1.250 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 5.624773e-02 1.250 0 0
EPHB-mediated forward signaling R-HSA-3928662 5.636927e-02 1.249 0 0
Netrin-1 signaling R-HSA-373752 5.636927e-02 1.249 0 0
Formation of definitive endoderm R-HSA-9823730 5.770772e-02 1.239 0 0
Breakdown of the nuclear lamina R-HSA-352238 6.369437e-02 1.196 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 6.369437e-02 1.196 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 6.507649e-02 1.187 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 6.982923e-02 1.156 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 6.982923e-02 1.156 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 6.982923e-02 1.156 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 6.982923e-02 1.156 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 6.982923e-02 1.156 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 6.982923e-02 1.156 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 6.982923e-02 1.156 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 6.811764e-02 1.167 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 7.010874e-02 1.154 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 7.010874e-02 1.154 0 0
Signaling downstream of RAS mutants R-HSA-9649948 7.010874e-02 1.154 0 0
Regulation of TNFR1 signaling R-HSA-5357905 7.010874e-02 1.154 0 0
Separation of Sister Chromatids R-HSA-2467813 6.350726e-02 1.197 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 6.497269e-02 1.187 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 6.423824e-02 1.192 0 0
Signaling by RAS mutants R-HSA-6802949 7.010874e-02 1.154 0 0
Adrenoceptors R-HSA-390696 6.507649e-02 1.187 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 5.953465e-02 1.225 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 6.697663e-02 1.174 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 6.507649e-02 1.187 0 0
Metabolism of RNA R-HSA-8953854 6.496558e-02 1.187 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 6.507649e-02 1.187 0 0
Sodium/Proton exchangers R-HSA-425986 6.507649e-02 1.187 0 0
Mitotic Anaphase R-HSA-68882 7.159497e-02 1.145 0 0
G2 Phase R-HSA-68911 7.164707e-02 1.145 0 0
NrCAM interactions R-HSA-447038 7.164707e-02 1.145 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 7.268270e-02 1.139 0 0
RET signaling R-HSA-8853659 7.358853e-02 1.133 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 7.509665e-02 1.124 0 0
S Phase R-HSA-69242 7.607989e-02 1.119 0 0
Cell-cell junction organization R-HSA-421270 7.905418e-02 1.102 0 0
Mitochondrial calcium ion transport R-HSA-8949215 7.919354e-02 1.101 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 7.929327e-02 1.101 0 0
Cellular responses to stress R-HSA-2262752 8.117756e-02 1.091 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 8.139430e-02 1.089 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 8.254376e-02 1.083 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 8.297478e-02 1.081 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.038100e-01 0.984 0 0
mRNA Editing: A to I Conversion R-HSA-75064 1.038100e-01 0.984 0 0
Diseases of cellular response to stress R-HSA-9675132 1.038100e-01 0.984 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.038100e-01 0.984 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.038100e-01 0.984 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.038100e-01 0.984 0 0
Regulation of cortical dendrite branching R-HSA-8985801 1.038100e-01 0.984 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.038100e-01 0.984 0 0
C6 deamination of adenosine R-HSA-75102 1.038100e-01 0.984 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.038100e-01 0.984 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.038100e-01 0.984 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.038100e-01 0.984 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.038100e-01 0.984 0 0
Potassium transport channels R-HSA-1296067 1.038100e-01 0.984 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.038100e-01 0.984 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.038100e-01 0.984 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.038100e-01 0.984 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.038100e-01 0.984 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.038100e-01 0.984 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 9.713301e-02 1.013 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 9.713301e-02 1.013 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 9.713301e-02 1.013 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 9.713301e-02 1.013 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 9.713301e-02 1.013 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 8.321233e-02 1.080 0 0
Regulated proteolysis of p75NTR R-HSA-193692 8.321233e-02 1.080 0 0
WNT mediated activation of DVL R-HSA-201688 8.321233e-02 1.080 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 8.505361e-02 1.070 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.018704e-01 0.992 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.018704e-01 0.992 0 0
Ephrin signaling R-HSA-3928664 9.722142e-02 1.012 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 8.538925e-02 1.069 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.213666e-02 1.036 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 8.867930e-02 1.052 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 8.867930e-02 1.052 0 0
Co-stimulation by CD28 R-HSA-389356 8.584839e-02 1.066 0 0
Chaperone Mediated Autophagy R-HSA-9613829 9.722142e-02 1.012 0 0
Apoptotic factor-mediated response R-HSA-111471 9.722142e-02 1.012 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 8.538925e-02 1.069 0 0
TNF signaling R-HSA-75893 1.033285e-01 0.986 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 8.538925e-02 1.069 0 0
Regulated Necrosis R-HSA-5218859 1.016221e-01 0.993 0 0
Cyclin D associated events in G1 R-HSA-69231 1.033619e-01 0.986 0 0
G1 Phase R-HSA-69236 1.033619e-01 0.986 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 1.005763e-01 0.998 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 1.035430e-01 0.985 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.003824e-01 0.998 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 8.321233e-02 1.080 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 9.896717e-02 1.005 0 0
DNA Replication R-HSA-69306 9.983687e-02 1.001 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 8.475821e-02 1.072 0 0
Developmental Biology R-HSA-1266738 8.789155e-02 1.056 0 0
NGF-stimulated transcription R-HSA-9031628 8.584839e-02 1.066 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 1.026293e-01 0.989 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.035430e-01 0.985 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 9.722142e-02 1.012 0 0
L1CAM interactions R-HSA-373760 8.685217e-02 1.061 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.035430e-01 0.985 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.016221e-01 0.993 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 8.460947e-02 1.073 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 9.146193e-02 1.039 0 0
SARS-CoV-1-host interactions R-HSA-9692914 9.049735e-02 1.043 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 9.722142e-02 1.012 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 9.713301e-02 1.013 0 0
Adherens junctions interactions R-HSA-418990 1.058731e-01 0.975 0 0
G1/S Transition R-HSA-69206 1.075534e-01 0.968 0 0
Signaling by NTRKs R-HSA-166520 1.079466e-01 0.967 0 0
Protein ubiquitination R-HSA-8852135 1.082068e-01 0.966 0 0
Muscle contraction R-HSA-397014 1.088411e-01 0.963 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.091694e-01 0.962 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.093036e-01 0.961 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.093036e-01 0.961 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.112820e-01 0.954 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.126789e-01 0.948 0 0
The NLRP3 inflammasome R-HSA-844456 1.126789e-01 0.948 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.126789e-01 0.948 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.132266e-01 0.946 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 1.135828e-01 0.945 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.144442e-01 0.941 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.144442e-01 0.941 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.144442e-01 0.941 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.159465e-01 0.936 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.159465e-01 0.936 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.271606e-01 0.896 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 1.271606e-01 0.896 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.271606e-01 0.896 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.271606e-01 0.896 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.271606e-01 0.896 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.488655e-01 0.827 0 0
Axonal growth stimulation R-HSA-209563 1.488655e-01 0.827 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.257099e-01 0.901 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 1.257099e-01 0.901 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.568723e-01 0.804 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.568723e-01 0.804 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.568723e-01 0.804 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.568723e-01 0.804 0 0
TRIF-mediated programmed cell death R-HSA-2562578 1.568723e-01 0.804 0 0
SOS-mediated signalling R-HSA-112412 1.568723e-01 0.804 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.568723e-01 0.804 0 0
Signaling by APC mutants R-HSA-4839744 1.258996e-01 0.900 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.258996e-01 0.900 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.258996e-01 0.900 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.258996e-01 0.900 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 1.500819e-01 0.824 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.202050e-01 0.920 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.202050e-01 0.920 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.399617e-01 0.854 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.399617e-01 0.854 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.225002e-01 0.912 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.197282e-01 0.922 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.448449e-01 0.839 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.496016e-01 0.825 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.184515e-01 0.926 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 1.502666e-01 0.823 0 0
ERK/MAPK targets R-HSA-198753 1.470205e-01 0.833 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.368016e-01 0.864 0 0
MAP2K and MAPK activation R-HSA-5674135 1.368016e-01 0.864 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.512545e-01 0.820 0 0
Peptide chain elongation R-HSA-156902 1.197282e-01 0.922 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 1.568723e-01 0.804 0 0
Signaling by WNT in cancer R-HSA-4791275 1.512545e-01 0.820 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.436143e-01 0.843 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.396074e-01 0.855 0 0
Oncogene Induced Senescence R-HSA-2559585 1.242143e-01 0.906 0 0
Neurexins and neuroligins R-HSA-6794361 1.234113e-01 0.909 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.247093e-01 0.904 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.462081e-01 0.835 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.500819e-01 0.824 0 0
Signaling by AXIN mutants R-HSA-4839735 1.500819e-01 0.824 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.234113e-01 0.909 0 0
Stimuli-sensing channels R-HSA-2672351 1.496016e-01 0.825 0 0
Glycolysis R-HSA-70171 1.294259e-01 0.888 0 0
Sensory processing of sound R-HSA-9659379 1.430821e-01 0.844 0 0
Interleukin-7 signaling R-HSA-1266695 1.341717e-01 0.872 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.202050e-01 0.920 0 0
Gene Silencing by RNA R-HSA-211000 1.415252e-01 0.849 0 0
Neuronal System R-HSA-112316 1.595073e-01 0.797 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.631083e-01 0.788 0 0
Heme signaling R-HSA-9707616 1.648016e-01 0.783 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.657716e-01 0.780 0 0
TCR signaling R-HSA-202403 1.665124e-01 0.779 0 0
Integrin signaling R-HSA-354192 1.667470e-01 0.778 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.667470e-01 0.778 0 0
Nuclear RNA decay R-HSA-9930044 1.667470e-01 0.778 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.667470e-01 0.778 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.667470e-01 0.778 0 0
G-protein beta:gamma signalling R-HSA-397795 1.667470e-01 0.778 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.667470e-01 0.778 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.688368e-01 0.773 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.718185e-01 0.765 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.758677e-01 0.755 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.381579e-01 0.623 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.381579e-01 0.623 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.381579e-01 0.623 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.381579e-01 0.623 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.381579e-01 0.623 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.381579e-01 0.623 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.381579e-01 0.623 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 2.381579e-01 0.623 0 0
Defective SLC26A4 causes Pendred syndrome (PDS) R-HSA-5619046 2.381579e-01 0.623 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 2.381579e-01 0.623 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.381579e-01 0.623 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.381579e-01 0.623 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.381579e-01 0.623 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.381579e-01 0.623 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.381579e-01 0.623 0 0
NADE modulates death signalling R-HSA-205025 1.969570e-01 0.706 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.969570e-01 0.706 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.969570e-01 0.706 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.969570e-01 0.706 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 1.969570e-01 0.706 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 1.969570e-01 0.706 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 1.969570e-01 0.706 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.969570e-01 0.706 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 3.350454e-01 0.475 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.350454e-01 0.475 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 3.350454e-01 0.475 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.350454e-01 0.475 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 3.350454e-01 0.475 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.350454e-01 0.475 0 0
IKBKB deficiency causes SCID R-HSA-5602636 3.350454e-01 0.475 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 3.350454e-01 0.475 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.350454e-01 0.475 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.350454e-01 0.475 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.350454e-01 0.475 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 3.350454e-01 0.475 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.350454e-01 0.475 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.350454e-01 0.475 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 3.350454e-01 0.475 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.350454e-01 0.475 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.350454e-01 0.475 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 3.350454e-01 0.475 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 3.350454e-01 0.475 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.350454e-01 0.475 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.350454e-01 0.475 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.350454e-01 0.475 0 0
Intestinal infectious diseases R-HSA-8942233 3.350454e-01 0.475 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.350454e-01 0.475 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 3.350454e-01 0.475 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 3.350454e-01 0.475 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.465847e-01 0.608 0 0
IRS activation R-HSA-74713 2.465847e-01 0.608 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.465847e-01 0.608 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 1.901052e-01 0.721 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 1.901052e-01 0.721 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 1.901052e-01 0.721 0 0
Regulation by c-FLIP R-HSA-3371378 1.901052e-01 0.721 0 0
RSK activation R-HSA-444257 1.901052e-01 0.721 0 0
Dimerization of procaspase-8 R-HSA-69416 1.901052e-01 0.721 0 0
p75NTR regulates axonogenesis R-HSA-193697 2.249060e-01 0.648 0 0
Lipophagy R-HSA-9613354 2.249060e-01 0.648 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 2.249060e-01 0.648 0 0
CASP8 activity is inhibited R-HSA-5218900 2.249060e-01 0.648 0 0
Signaling by MAPK mutants R-HSA-9652817 2.965811e-01 0.528 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 4.196162e-01 0.377 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.196162e-01 0.377 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.196162e-01 0.377 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.196162e-01 0.377 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 4.196162e-01 0.377 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.196162e-01 0.377 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 4.196162e-01 0.377 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 4.196162e-01 0.377 0 0
Formation of axial mesoderm R-HSA-9796292 2.030212e-01 0.692 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.030212e-01 0.692 0 0
Formation of apoptosome R-HSA-111458 2.607992e-01 0.584 0 0
Regulation of the apoptosome activity R-HSA-9627069 2.607992e-01 0.584 0 0
PI3K/AKT activation R-HSA-198203 2.607992e-01 0.584 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.607992e-01 0.584 0 0
Folding of actin by CCT/TriC R-HSA-390450 2.607992e-01 0.584 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 2.607992e-01 0.584 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.460502e-01 0.461 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 3.460502e-01 0.461 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.460502e-01 0.461 0 0
ChREBP activates metabolic gene expression R-HSA-163765 2.973465e-01 0.527 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 2.973465e-01 0.527 0 0
DCC mediated attractive signaling R-HSA-418885 2.604662e-01 0.584 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.604662e-01 0.584 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.604662e-01 0.584 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.604662e-01 0.584 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.604662e-01 0.584 0 0
E2F mediated regulation of DNA replication R-HSA-113510 2.307726e-01 0.637 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 2.060306e-01 0.686 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.829310e-01 0.738 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.273556e-01 0.643 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 2.557294e-01 0.592 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.557294e-01 0.592 0 0
Differentiation of T cells R-HSA-9945266 2.902813e-01 0.537 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 2.902813e-01 0.537 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.902813e-01 0.537 0 0
Phosphorylation of the APC/C R-HSA-176412 2.902813e-01 0.537 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 3.341520e-01 0.476 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 3.341520e-01 0.476 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 3.341520e-01 0.476 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 3.341520e-01 0.476 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 3.943179e-01 0.404 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.943179e-01 0.404 0 0
PTK6 Expression R-HSA-8849473 3.943179e-01 0.404 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 3.943179e-01 0.404 0 0
Disinhibition of SNARE formation R-HSA-114516 3.943179e-01 0.404 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 3.943179e-01 0.404 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.943179e-01 0.404 0 0
The NLRP1 inflammasome R-HSA-844455 4.934352e-01 0.307 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 4.934352e-01 0.307 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.934352e-01 0.307 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.934352e-01 0.307 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.934352e-01 0.307 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 4.934352e-01 0.307 0 0
Defective ABCA1 causes TGD R-HSA-5682113 4.934352e-01 0.307 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 4.934352e-01 0.307 0 0
Defective HPRT1 disrupts guanine and hypoxanthine salvage R-HSA-9734281 4.934352e-01 0.307 0 0
Invadopodia formation R-HSA-8941237 4.934352e-01 0.307 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.800090e-01 0.745 0 0
RAF activation R-HSA-5673000 1.997613e-01 0.699 0 0
Activation of the pre-replicative complex R-HSA-68962 2.225936e-01 0.652 0 0
Tight junction interactions R-HSA-420029 2.493477e-01 0.603 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 3.205208e-01 0.494 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.205208e-01 0.494 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.205208e-01 0.494 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.205208e-01 0.494 0 0
Trafficking of AMPA receptors R-HSA-399719 2.423438e-01 0.616 0 0
p75NTR recruits signalling complexes R-HSA-209543 3.708654e-01 0.431 0 0
Leading Strand Synthesis R-HSA-69109 3.708654e-01 0.431 0 0
Polymerase switching R-HSA-69091 3.708654e-01 0.431 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 3.708654e-01 0.431 0 0
Scavenging by Class F Receptors R-HSA-3000484 3.708654e-01 0.431 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 2.626202e-01 0.581 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.999496e-01 0.699 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.509721e-01 0.455 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 4.408899e-01 0.356 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 4.408899e-01 0.356 0 0
Formation of annular gap junctions R-HSA-196025 4.408899e-01 0.356 0 0
Activation of RAS in B cells R-HSA-1169092 4.408899e-01 0.356 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 4.408899e-01 0.356 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 4.408899e-01 0.356 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.141937e-01 0.669 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.833481e-01 0.548 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 4.071823e-01 0.390 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.814378e-01 0.419 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.602112e-01 0.443 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.926701e-01 0.715 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.419612e-01 0.466 0 0
Attenuation phase R-HSA-3371568 3.113871e-01 0.507 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.030718e-01 0.692 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 2.861311e-01 0.543 0 0
HSF1-dependent transactivation R-HSA-3371571 2.861311e-01 0.543 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 2.000717e-01 0.699 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.100278e-01 0.678 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.657738e-01 0.437 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 3.867999e-01 0.413 0 0
Deadenylation of mRNA R-HSA-429947 3.867999e-01 0.413 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 4.117374e-01 0.385 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 4.117374e-01 0.385 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 4.117374e-01 0.385 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 4.428430e-01 0.354 0 0
Removal of the Flap Intermediate R-HSA-69166 4.428430e-01 0.354 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 4.428430e-01 0.354 0 0
Gap junction degradation R-HSA-190873 4.854170e-01 0.314 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 4.854170e-01 0.314 0 0
ALK mutants bind TKIs R-HSA-9700645 4.854170e-01 0.314 0 0
snRNP Assembly R-HSA-191859 3.071457e-01 0.513 0 0
Metabolism of non-coding RNA R-HSA-194441 3.071457e-01 0.513 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.205392e-01 0.494 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.512794e-01 0.454 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.235933e-01 0.490 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.133199e-01 0.384 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.133199e-01 0.384 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.714643e-01 0.430 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 4.417081e-01 0.355 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 4.417081e-01 0.355 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 4.417081e-01 0.355 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 4.417081e-01 0.355 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 4.417081e-01 0.355 0 0
Viral mRNA Translation R-HSA-192823 2.946913e-01 0.531 0 0
Erythropoietin activates RAS R-HSA-9027284 4.776308e-01 0.321 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 4.776308e-01 0.321 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 4.776308e-01 0.321 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 4.776308e-01 0.321 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 4.396578e-01 0.357 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 4.712054e-01 0.327 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 5.276660e-01 0.278 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 5.276660e-01 0.278 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 4.347983e-01 0.362 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 4.657092e-01 0.332 0 0
Interaction between L1 and Ankyrins R-HSA-445095 4.657092e-01 0.332 0 0
Striated Muscle Contraction R-HSA-390522 4.608610e-01 0.336 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 4.608610e-01 0.336 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 5.113686e-01 0.291 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 4.564893e-01 0.341 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 3.503287e-01 0.456 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 5.001027e-01 0.301 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 4.913797e-01 0.309 0 0
Formation of the Early Elongation Complex R-HSA-113418 4.913797e-01 0.309 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 4.841823e-01 0.315 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 4.841823e-01 0.315 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 4.841823e-01 0.315 0 0
Translation initiation complex formation R-HSA-72649 4.676372e-01 0.330 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 4.992785e-01 0.302 0 0
HIV Transcription Initiation R-HSA-167161 4.992785e-01 0.302 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 4.992785e-01 0.302 0 0
Signaling by Erythropoietin R-HSA-9006335 5.165844e-01 0.287 0 0
Late endosomal microautophagy R-HSA-9615710 5.165844e-01 0.287 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 5.049436e-01 0.297 0 0
Neutrophil degranulation R-HSA-6798695 4.180467e-01 0.379 0 0
Transcription of the HIV genome R-HSA-167172 4.590136e-01 0.338 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 4.557383e-01 0.341 0 0
Specification of the neural plate border R-HSA-9834899 2.307726e-01 0.637 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.065729e-01 0.685 0 0
p75NTR signals via NF-kB R-HSA-193639 2.604662e-01 0.584 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.100278e-01 0.678 0 0
Hedgehog 'off' state R-HSA-5610787 1.866442e-01 0.729 0 0
Telomere Extension By Telomerase R-HSA-171319 3.183136e-01 0.497 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.932265e-01 0.714 0 0
mRNA Editing R-HSA-75072 2.249060e-01 0.648 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 3.341520e-01 0.476 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 3.205208e-01 0.494 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.322942e-01 0.364 0 0
Termination of translesion DNA synthesis R-HSA-5656169 5.165844e-01 0.287 0 0
Synaptic adhesion-like molecules R-HSA-8849932 2.065729e-01 0.685 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 4.408899e-01 0.356 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.072385e-01 0.684 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.833090e-01 0.548 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.833090e-01 0.548 0 0
Signaling by ERBB2 R-HSA-1227986 3.235933e-01 0.490 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 3.739300e-01 0.427 0 0
Signaling by PTK6 R-HSA-8848021 3.739094e-01 0.427 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.739094e-01 0.427 0 0
Aggrephagy R-HSA-9646399 3.113871e-01 0.507 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.592470e-01 0.586 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 2.465847e-01 0.608 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.474833e-01 0.459 0 0
Processive synthesis on the lagging strand R-HSA-69183 4.776308e-01 0.321 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 3.208135e-01 0.494 0 0
Frs2-mediated activation R-HSA-170968 2.030212e-01 0.692 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 2.249060e-01 0.648 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 2.607992e-01 0.584 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 4.071823e-01 0.390 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 3.258552e-01 0.487 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 2.271079e-01 0.644 0 0
RMTs methylate histone arginines R-HSA-3214858 4.120264e-01 0.385 0 0
Formation of lateral plate mesoderm R-HSA-9758920 2.965811e-01 0.528 0 0
Processing of SMDT1 R-HSA-8949664 2.030212e-01 0.692 0 0
Regulation of CDH11 function R-HSA-9762292 2.607992e-01 0.584 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 2.607992e-01 0.584 0 0
LGI-ADAM interactions R-HSA-5682910 2.973465e-01 0.527 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 4.408899e-01 0.356 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.854170e-01 0.314 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 4.129876e-01 0.384 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.113686e-01 0.291 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.420192e-01 0.355 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 3.859648e-01 0.413 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 2.884678e-01 0.540 0 0
Resolution of D-Loop Structures R-HSA-5693537 4.608610e-01 0.336 0 0
Generation of second messenger molecules R-HSA-202433 1.954832e-01 0.709 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 2.949285e-01 0.530 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.434892e-01 0.614 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.969570e-01 0.706 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 2.465847e-01 0.608 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 2.249060e-01 0.648 0 0
NF-kB is activated and signals survival R-HSA-209560 3.341520e-01 0.476 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 3.708654e-01 0.431 0 0
Telomere C-strand synthesis initiation R-HSA-174430 4.776308e-01 0.321 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 4.372830e-01 0.359 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 5.113686e-01 0.291 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.434892e-01 0.614 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.396578e-01 0.357 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 3.058383e-01 0.515 0 0
Signal attenuation R-HSA-74749 2.607992e-01 0.584 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 1.829310e-01 0.738 0 0
Repression of WNT target genes R-HSA-4641265 3.708654e-01 0.431 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.512794e-01 0.454 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 4.435091e-01 0.353 0 0
Prolonged ERK activation events R-HSA-169893 2.902813e-01 0.537 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 2.756907e-01 0.560 0 0
Integration of energy metabolism R-HSA-163685 2.043394e-01 0.690 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 2.202111e-01 0.657 0 0
Autophagy R-HSA-9612973 4.185974e-01 0.378 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 1.999848e-01 0.699 0 0
TGFBR3 PTM regulation R-HSA-9839383 1.901052e-01 0.721 0 0
Calcineurin activates NFAT R-HSA-2025928 2.249060e-01 0.648 0 0
HDL assembly R-HSA-8963896 2.313010e-01 0.636 0 0
Abacavir transmembrane transport R-HSA-2161517 3.460502e-01 0.461 0 0
Ca2+ activated K+ channels R-HSA-1296052 3.943179e-01 0.404 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 3.044517e-01 0.516 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 4.133199e-01 0.384 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 2.756907e-01 0.560 0 0
Signaling by SCF-KIT R-HSA-1433557 3.917319e-01 0.407 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 3.093298e-01 0.510 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 4.322942e-01 0.364 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 4.614560e-01 0.336 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 5.202702e-01 0.284 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 4.355374e-01 0.361 0 0
Selective autophagy R-HSA-9663891 3.443464e-01 0.463 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 2.682724e-01 0.571 0 0
Signaling by Hedgehog R-HSA-5358351 4.492769e-01 0.347 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.714643e-01 0.430 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 5.259700e-01 0.279 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 3.093298e-01 0.510 0 0
Potassium Channels R-HSA-1296071 3.859648e-01 0.413 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.657738e-01 0.437 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 3.728149e-01 0.429 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 3.728149e-01 0.429 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.100278e-01 0.678 0 0
Regulation of KIT signaling R-HSA-1433559 2.313010e-01 0.636 0 0
mTORC1-mediated signalling R-HSA-166208 1.854712e-01 0.732 1 1
Platelet calcium homeostasis R-HSA-418360 2.034425e-01 0.692 0 0
Pyroptosis R-HSA-5620971 4.913797e-01 0.309 0 0
Macroautophagy R-HSA-1632852 4.847509e-01 0.314 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 5.155585e-01 0.288 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 2.630377e-01 0.580 0 0
Adaptive Immune System R-HSA-1280218 3.182338e-01 0.497 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.171891e-01 0.663 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 2.970760e-01 0.527 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 1.969570e-01 0.706 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 2.965811e-01 0.528 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.604662e-01 0.584 0 0
Eukaryotic Translation Termination R-HSA-72764 2.030718e-01 0.692 0 0
FGFR1 mutant receptor activation R-HSA-1839124 4.372830e-01 0.359 0 0
Transmission across Chemical Synapses R-HSA-112315 3.836581e-01 0.416 0 0
Activation of BH3-only proteins R-HSA-114452 2.225936e-01 0.652 0 0
Neurofascin interactions R-HSA-447043 3.460502e-01 0.461 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.780011e-01 0.321 0 0
Interleukin-1 family signaling R-HSA-446652 4.548402e-01 0.342 0 0
Signalling to ERKs R-HSA-187687 5.071791e-01 0.295 0 0
GPVI-mediated activation cascade R-HSA-114604 3.692622e-01 0.433 0 0
Interleukin-2 family signaling R-HSA-451927 3.113871e-01 0.507 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.813383e-01 0.742 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.042607e-01 0.690 0 0
Inhibition of PKR R-HSA-169131 2.381579e-01 0.623 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 1.901052e-01 0.721 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 2.249060e-01 0.648 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 2.965811e-01 0.528 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.965811e-01 0.528 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 4.196162e-01 0.377 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.065729e-01 0.685 0 0
Bicarbonate transporters R-HSA-425381 2.973465e-01 0.527 0 0
Phase 4 - resting membrane potential R-HSA-5576886 2.902813e-01 0.537 0 0
MET interacts with TNS proteins R-HSA-8875513 4.934352e-01 0.307 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 2.493477e-01 0.603 0 0
Signaling by LTK R-HSA-9842663 3.708654e-01 0.431 0 0
Co-stimulation by ICOS R-HSA-9927354 4.408899e-01 0.356 0 0
MAP kinase activation R-HSA-450294 2.353865e-01 0.628 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 4.428430e-01 0.354 0 0
cGMP effects R-HSA-418457 4.428430e-01 0.354 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 2.345045e-01 0.630 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 4.396578e-01 0.357 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 4.712054e-01 0.327 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.347983e-01 0.362 0 0
Cristae formation R-HSA-8949613 4.657092e-01 0.332 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 5.113686e-01 0.291 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 4.448656e-01 0.352 0 0
RAF/MAP kinase cascade R-HSA-5673001 5.225966e-01 0.282 0 0
Regulation of insulin secretion R-HSA-422356 3.186951e-01 0.497 0 0
Mitochondrial biogenesis R-HSA-1592230 5.143561e-01 0.289 0 0
Inflammasomes R-HSA-622312 1.849608e-01 0.733 0 0
MAPK family signaling cascades R-HSA-5683057 3.482094e-01 0.458 0 0
Interleukin-17 signaling R-HSA-448424 3.739300e-01 0.427 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.833481e-01 0.548 0 0
Effects of PIP2 hydrolysis R-HSA-114508 4.608610e-01 0.336 0 0
Aquaporin-mediated transport R-HSA-445717 3.402257e-01 0.468 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 1.886980e-01 0.724 0 0
PECAM1 interactions R-HSA-210990 2.973465e-01 0.527 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.073255e-01 0.512 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.336763e-01 0.477 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.258552e-01 0.487 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.854170e-01 0.314 0 0
Receptor Mediated Mitophagy R-HSA-8934903 5.276660e-01 0.278 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.075408e-01 0.390 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 5.165844e-01 0.287 0 0
Signaling by ERBB4 R-HSA-1236394 3.278008e-01 0.484 0 0
Negative regulation of FLT3 R-HSA-9706369 2.902813e-01 0.537 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 4.372830e-01 0.359 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 5.276660e-01 0.278 0 0
Negative regulation of MAPK pathway R-HSA-5675221 3.512794e-01 0.454 0 0
Co-inhibition by PD-1 R-HSA-389948 3.656414e-01 0.437 0 0
SARS-CoV-2-host interactions R-HSA-9705683 5.045573e-01 0.297 0 0
Interleukin-1 processing R-HSA-448706 2.249060e-01 0.648 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.965811e-01 0.528 0 0
Nef and signal transduction R-HSA-164944 3.460502e-01 0.461 0 0
CHL1 interactions R-HSA-447041 3.943179e-01 0.404 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 4.408899e-01 0.356 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 4.071823e-01 0.390 0 0
Protein hydroxylation R-HSA-9629569 4.417081e-01 0.355 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.839510e-01 0.735 0 0
Amine ligand-binding receptors R-HSA-375280 4.120264e-01 0.385 0 0
NOD1/2 Signaling Pathway R-HSA-168638 4.841823e-01 0.315 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 2.833090e-01 0.548 0 0
TGFBR3 expression R-HSA-9839394 4.133199e-01 0.384 0 0
ISG15 antiviral mechanism R-HSA-1169408 4.551550e-01 0.342 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.602112e-01 0.443 0 0
DSCAM interactions R-HSA-376172 4.196162e-01 0.377 0 0
Tandem pore domain potassium channels R-HSA-1296346 2.607992e-01 0.584 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.934352e-01 0.307 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 4.934352e-01 0.307 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 3.509721e-01 0.455 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 3.258552e-01 0.487 0 0
ARMS-mediated activation R-HSA-170984 4.854170e-01 0.314 0 0
Protein methylation R-HSA-8876725 4.776308e-01 0.321 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 5.276660e-01 0.278 0 0
Signaling by PDGFR in disease R-HSA-9671555 5.001027e-01 0.301 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.676372e-01 0.330 0 0
Regulation of gene expression in beta cells R-HSA-210745 5.165844e-01 0.287 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 4.874459e-01 0.312 0 0
Signaling by NOTCH R-HSA-157118 3.495690e-01 0.456 0 0
Cytokine Signaling in Immune system R-HSA-1280215 4.419019e-01 0.355 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.000717e-01 0.699 0 0
Signaling by TGFBR3 R-HSA-9839373 3.165796e-01 0.500 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 3.871123e-01 0.412 0 0
Signaling by ALK in cancer R-HSA-9700206 2.000717e-01 0.699 0 0
Histamine receptors R-HSA-390650 4.934352e-01 0.307 0 0
Interleukin-37 signaling R-HSA-9008059 2.225936e-01 0.652 0 0
Selenocysteine synthesis R-HSA-2408557 2.705494e-01 0.568 0 0
Signaling by Interleukins R-HSA-449147 2.010936e-01 0.697 0 0
Syndecan interactions R-HSA-3000170 3.602112e-01 0.443 0 0
Formation of the anterior neural plate R-HSA-9823739 4.776308e-01 0.321 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.937055e-01 0.713 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 2.965811e-01 0.528 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.196162e-01 0.377 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 4.196162e-01 0.377 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.943179e-01 0.404 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 3.943179e-01 0.404 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 4.934352e-01 0.307 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 4.934352e-01 0.307 0 0
Interleukin-18 signaling R-HSA-9012546 4.408899e-01 0.356 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 3.070130e-01 0.513 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 5.276660e-01 0.278 0 0
Glucose metabolism R-HSA-70326 3.324258e-01 0.478 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 4.047712e-01 0.393 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 5.001027e-01 0.301 0 0
PI Metabolism R-HSA-1483255 3.713730e-01 0.430 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 2.902813e-01 0.537 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.915350e-01 0.535 0 0
Influenza Infection R-HSA-168255 4.435037e-01 0.353 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 3.943179e-01 0.404 0 0
FasL/ CD95L signaling R-HSA-75157 4.934352e-01 0.307 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.854170e-01 0.314 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 4.854170e-01 0.314 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.012254e-01 0.696 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 3.739094e-01 0.427 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.814378e-01 0.419 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 4.712054e-01 0.327 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.066992e-01 0.685 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 4.071823e-01 0.390 0 0
Interleukin-12 signaling R-HSA-9020591 3.582935e-01 0.446 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 4.428430e-01 0.354 0 0
Signaling by Leptin R-HSA-2586552 5.276660e-01 0.278 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 5.282912e-01 0.277 0 0
Triglyceride catabolism R-HSA-163560 5.297902e-01 0.276 0 0
Organelle biogenesis and maintenance R-HSA-1852241 5.344253e-01 0.272 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 5.409292e-01 0.267 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.412487e-01 0.267 0 0
DAP12 signaling R-HSA-2424491 5.412487e-01 0.267 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 5.412487e-01 0.267 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 5.412487e-01 0.267 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 5.412487e-01 0.267 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 5.414416e-01 0.266 0 0
Interleukin-12 family signaling R-HSA-447115 5.433789e-01 0.265 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 5.439159e-01 0.264 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 5.439159e-01 0.264 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.439159e-01 0.264 0 0
Phase 2 - plateau phase R-HSA-5576893 5.439159e-01 0.264 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 5.439159e-01 0.264 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 5.439159e-01 0.264 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.439159e-01 0.264 0 0
Disorders of Developmental Biology R-HSA-9675151 5.439159e-01 0.264 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 5.439159e-01 0.264 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 5.439159e-01 0.264 0 0
Signaling by TGFB family members R-HSA-9006936 5.444852e-01 0.264 0 0
PTEN Regulation R-HSA-6807070 5.481541e-01 0.261 0 0
Voltage gated Potassium channels R-HSA-1296072 5.519603e-01 0.258 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.519603e-01 0.258 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 5.556792e-01 0.255 0 0
Cilium Assembly R-HSA-5617833 5.574148e-01 0.254 0 0
MTF1 activates gene expression R-HSA-5660489 5.578690e-01 0.253 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.578690e-01 0.253 0 0
HCN channels R-HSA-1296061 5.578690e-01 0.253 0 0
ATP sensitive Potassium channels R-HSA-1296025 5.578690e-01 0.253 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.578690e-01 0.253 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.578690e-01 0.253 0 0
Defective MAT1A causes MATD R-HSA-5579024 5.578690e-01 0.253 0 0
Regulation of gap junction activity R-HSA-191650 5.578690e-01 0.253 0 0
Alanine metabolism R-HSA-8964540 5.578690e-01 0.253 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 5.578690e-01 0.253 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 5.578690e-01 0.253 0 0
Sensory perception of sour taste R-HSA-9729555 5.578690e-01 0.253 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 5.578690e-01 0.253 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.578690e-01 0.253 0 0
Interleukin-1 signaling R-HSA-9020702 5.583432e-01 0.253 0 0
Extension of Telomeres R-HSA-180786 5.593068e-01 0.252 0 0
Cellular response to heat stress R-HSA-3371556 5.651932e-01 0.248 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 5.653073e-01 0.248 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 5.653073e-01 0.248 0 0
Downstream signal transduction R-HSA-186763 5.653073e-01 0.248 0 0
Toll-like Receptor Cascades R-HSA-168898 5.674822e-01 0.246 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 5.674962e-01 0.246 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 5.674962e-01 0.246 0 0
Formation of the posterior neural plate R-HSA-9832991 5.674962e-01 0.246 0 0
Interleukin-2 signaling R-HSA-9020558 5.674962e-01 0.246 0 0
Ionotropic activity of kainate receptors R-HSA-451306 5.674962e-01 0.246 0 0
Synthesis of PI R-HSA-1483226 5.674962e-01 0.246 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 5.694328e-01 0.245 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.694328e-01 0.245 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 5.736404e-01 0.241 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 5.736404e-01 0.241 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 5.751651e-01 0.240 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 5.751651e-01 0.240 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 5.751651e-01 0.240 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 5.751651e-01 0.240 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 5.751651e-01 0.240 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 5.751651e-01 0.240 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 5.751651e-01 0.240 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 5.768780e-01 0.239 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 5.768780e-01 0.239 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 5.768780e-01 0.239 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 5.768780e-01 0.239 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 5.768780e-01 0.239 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 5.807345e-01 0.236 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 5.810828e-01 0.236 0 0
Fanconi Anemia Pathway R-HSA-6783310 5.810828e-01 0.236 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 5.821908e-01 0.235 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 5.821908e-01 0.235 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 5.821908e-01 0.235 0 0
Plasma lipoprotein assembly R-HSA-8963898 5.821908e-01 0.235 0 0
Downstream TCR signaling R-HSA-202424 5.873541e-01 0.231 0 0
Regulation of PTEN stability and activity R-HSA-8948751 5.878641e-01 0.231 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 5.878641e-01 0.231 0 0
MHC class II antigen presentation R-HSA-2132295 5.899003e-01 0.229 0 0
Signaling by NOTCH1 R-HSA-1980143 5.900654e-01 0.229 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.941295e-01 0.226 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 5.947878e-01 0.226 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 6.005049e-01 0.221 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 6.005049e-01 0.221 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 6.005049e-01 0.221 0 0
Diseases of DNA repair R-HSA-9675135 6.005049e-01 0.221 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 6.048393e-01 0.218 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 6.048393e-01 0.218 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 6.048393e-01 0.218 0 0
ERKs are inactivated R-HSA-202670 6.048393e-01 0.218 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 6.048393e-01 0.218 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 6.048393e-01 0.218 0 0
Sodium/Calcium exchangers R-HSA-425561 6.048393e-01 0.218 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.050379e-01 0.218 0 0
Mismatch Repair R-HSA-5358508 6.050379e-01 0.218 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.050379e-01 0.218 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 6.077656e-01 0.216 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 6.077656e-01 0.216 0 0
Long-term potentiation R-HSA-9620244 6.077656e-01 0.216 0 0
Formation of the nephric duct R-HSA-9830364 6.077656e-01 0.216 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.106833e-01 0.214 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 6.113939e-01 0.214 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 6.113939e-01 0.214 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 6.141102e-01 0.212 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 6.141102e-01 0.212 0 0
PTK6 Down-Regulation R-HSA-8849472 6.141102e-01 0.212 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 6.141102e-01 0.212 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.141102e-01 0.212 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 6.141102e-01 0.212 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 6.141102e-01 0.212 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 6.141102e-01 0.212 0 0
Activation of AKT2 R-HSA-165158 6.141102e-01 0.212 0 0
PTK6 Activates STAT3 R-HSA-8849474 6.141102e-01 0.212 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 6.141102e-01 0.212 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 6.141102e-01 0.212 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 6.141102e-01 0.212 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 6.141102e-01 0.212 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 6.153655e-01 0.211 0 0
HIV Transcription Elongation R-HSA-167169 6.153655e-01 0.211 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 6.153655e-01 0.211 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 6.153655e-01 0.211 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 6.153655e-01 0.211 0 0
HCMV Early Events R-HSA-9609690 6.165881e-01 0.210 0 0
Vesicle-mediated transport R-HSA-5653656 6.181196e-01 0.209 0 0
Adipogenesis R-HSA-9843745 6.186687e-01 0.209 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 6.194493e-01 0.208 0 0
Signaling by NOTCH3 R-HSA-9012852 6.235392e-01 0.205 0 0
Myogenesis R-HSA-525793 6.323570e-01 0.199 0 0
Metalloprotease DUBs R-HSA-5689901 6.323570e-01 0.199 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 6.323570e-01 0.199 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 6.333372e-01 0.198 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.334820e-01 0.198 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.334820e-01 0.198 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 6.334820e-01 0.198 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 6.353425e-01 0.197 0 0
GPER1 signaling R-HSA-9634597 6.378905e-01 0.195 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 6.378905e-01 0.195 0 0
Metal ion SLC transporters R-HSA-425410 6.378905e-01 0.195 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 6.396835e-01 0.194 0 0
IRAK1 recruits IKK complex R-HSA-937039 6.396835e-01 0.194 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 6.396835e-01 0.194 0 0
GRB2 events in EGFR signaling R-HSA-179812 6.396835e-01 0.194 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 6.396835e-01 0.194 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 6.396835e-01 0.194 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 6.396835e-01 0.194 0 0
Pervasive developmental disorders R-HSA-9005895 6.396835e-01 0.194 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 6.396835e-01 0.194 0 0
Disorders of Nervous System Development R-HSA-9697154 6.396835e-01 0.194 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 6.396835e-01 0.194 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 6.396835e-01 0.194 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 6.396835e-01 0.194 0 0
Interleukin-15 signaling R-HSA-8983432 6.396835e-01 0.194 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 6.429572e-01 0.192 0 0
IGF1R signaling cascade R-HSA-2428924 6.437463e-01 0.191 0 0
Nuclear import of Rev protein R-HSA-180746 6.545043e-01 0.184 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 6.546932e-01 0.184 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 6.546932e-01 0.184 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 6.546932e-01 0.184 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 6.558066e-01 0.183 0 0
DNA Damage Bypass R-HSA-73893 6.558066e-01 0.183 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 6.559312e-01 0.183 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 6.559312e-01 0.183 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 6.559312e-01 0.183 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 6.559312e-01 0.183 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 6.559312e-01 0.183 0 0
IRS-mediated signalling R-HSA-112399 6.574818e-01 0.182 0 0
Cellular response to chemical stress R-HSA-9711123 6.586460e-01 0.181 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 6.595114e-01 0.181 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.604675e-01 0.180 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 6.604675e-01 0.180 0 0
Nephrin family interactions R-HSA-373753 6.604675e-01 0.180 0 0
Signal transduction by L1 R-HSA-445144 6.604675e-01 0.180 0 0
Switching of origins to a post-replicative state R-HSA-69052 6.617691e-01 0.179 0 0
Ca2+ pathway R-HSA-4086398 6.617691e-01 0.179 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.632001e-01 0.178 0 0
PDE3B signalling R-HSA-165160 6.632001e-01 0.178 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.632001e-01 0.178 0 0
PKB-mediated events R-HSA-109703 6.632001e-01 0.178 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.632001e-01 0.178 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 6.632001e-01 0.178 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 6.632001e-01 0.178 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 6.632001e-01 0.178 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.632001e-01 0.178 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.632001e-01 0.178 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.632001e-01 0.178 0 0
Pentose phosphate pathway disease R-HSA-6791465 6.632001e-01 0.178 0 0
NGF-independant TRKA activation R-HSA-187024 6.632001e-01 0.178 0 0
Sensory perception of salty taste R-HSA-9730628 6.632001e-01 0.178 0 0
Synthesis of PS R-HSA-1483101 6.632001e-01 0.178 0 0
Formation of the Editosome R-HSA-75094 6.632001e-01 0.178 0 0
Ceramide signalling R-HSA-193681 6.632001e-01 0.178 0 0
Phosphorylation of Emi1 R-HSA-176417 6.632001e-01 0.178 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 6.632001e-01 0.178 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.632001e-01 0.178 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.632001e-01 0.178 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.632001e-01 0.178 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 6.632001e-01 0.178 0 0
TRAIL signaling R-HSA-75158 6.632001e-01 0.178 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 6.632001e-01 0.178 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.632001e-01 0.178 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 6.641746e-01 0.178 0 0
CD28 dependent Vav1 pathway R-HSA-389359 6.720603e-01 0.173 0 0
Acetylcholine binding and downstream events R-HSA-181431 6.720603e-01 0.173 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 6.720603e-01 0.173 0 0
Adenylate cyclase activating pathway R-HSA-170660 6.720603e-01 0.173 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 6.720603e-01 0.173 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 6.720603e-01 0.173 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 6.720603e-01 0.173 0 0
rRNA modification in the mitochondrion R-HSA-6793080 6.720603e-01 0.173 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 6.720603e-01 0.173 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 6.720603e-01 0.173 0 0
Maturation of nucleoprotein R-HSA-9683610 6.720603e-01 0.173 0 0
PI3K Cascade R-HSA-109704 6.731797e-01 0.172 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 6.737588e-01 0.171 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 6.748728e-01 0.171 0 0
Signaling by FGFR in disease R-HSA-1226099 6.763301e-01 0.170 0 0
Late Phase of HIV Life Cycle R-HSA-162599 6.770817e-01 0.169 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 6.784658e-01 0.168 0 0
HIV elongation arrest and recovery R-HSA-167287 6.784658e-01 0.168 0 0
Pausing and recovery of HIV elongation R-HSA-167290 6.784658e-01 0.168 0 0
Cellular response to starvation R-HSA-9711097 6.826455e-01 0.166 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 6.859836e-01 0.164 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 6.859836e-01 0.164 0 0
Lagging Strand Synthesis R-HSA-69186 6.859836e-01 0.164 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 6.859836e-01 0.164 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.895548e-01 0.161 0 0
Ion channel transport R-HSA-983712 6.932571e-01 0.159 0 0
HSF1 activation R-HSA-3371511 6.944273e-01 0.158 0 0
FLT3 signaling in disease R-HSA-9682385 6.944273e-01 0.158 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 6.972910e-01 0.157 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.999491e-01 0.155 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 6.999491e-01 0.155 0 0
Signaling by FGFR4 in disease R-HSA-5655291 7.020335e-01 0.154 0 0
Physiological factors R-HSA-5578768 7.020335e-01 0.154 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 7.020335e-01 0.154 0 0
Ribosome-associated quality control R-HSA-9948299 7.053581e-01 0.152 0 0
STAT5 Activation R-HSA-9645135 7.060477e-01 0.151 0 0
Erythropoietin activates STAT5 R-HSA-9027283 7.060477e-01 0.151 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 7.060477e-01 0.151 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 7.060477e-01 0.151 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 7.060477e-01 0.151 0 0
NADPH regeneration R-HSA-389542 7.060477e-01 0.151 0 0
HDL clearance R-HSA-8964011 7.060477e-01 0.151 0 0
Lipid particle organization R-HSA-8964572 7.060477e-01 0.151 0 0
Orc1 removal from chromatin R-HSA-68949 7.062437e-01 0.151 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 7.088085e-01 0.149 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.100360e-01 0.149 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.100360e-01 0.149 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 7.100360e-01 0.149 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 7.131585e-01 0.147 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 7.131585e-01 0.147 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 7.131585e-01 0.147 0 0
Circadian clock R-HSA-9909396 7.136707e-01 0.147 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 7.187799e-01 0.143 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.203782e-01 0.142 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.203782e-01 0.142 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 7.254983e-01 0.139 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 7.254983e-01 0.139 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 7.254983e-01 0.139 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 7.254983e-01 0.139 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 7.296906e-01 0.137 0 0
Translesion synthesis by REV1 R-HSA-110312 7.296906e-01 0.137 0 0
SHC1 events in EGFR signaling R-HSA-180336 7.296906e-01 0.137 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 7.296906e-01 0.137 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 7.296906e-01 0.137 0 0
MET promotes cell motility R-HSA-8875878 7.310630e-01 0.136 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.326439e-01 0.135 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.326439e-01 0.135 0 0
FGFR2 alternative splicing R-HSA-6803529 7.326439e-01 0.135 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.326439e-01 0.135 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.326439e-01 0.135 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.326439e-01 0.135 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 7.339684e-01 0.134 0 0
rRNA processing R-HSA-72312 7.367104e-01 0.133 0 0
Developmental Cell Lineages R-HSA-9734767 7.367300e-01 0.133 0 0
Immune System R-HSA-168256 7.378474e-01 0.132 0 0
Selenoamino acid metabolism R-HSA-2408522 7.384354e-01 0.132 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 7.397586e-01 0.131 0 0
EGFR downregulation R-HSA-182971 7.397586e-01 0.131 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 7.415061e-01 0.130 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 7.415061e-01 0.130 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 7.418146e-01 0.130 0 0
Netrin mediated repulsion signals R-HSA-418886 7.434464e-01 0.129 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 7.434464e-01 0.129 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.434464e-01 0.129 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 7.434464e-01 0.129 0 0
mRNA Editing: C to U Conversion R-HSA-72200 7.434464e-01 0.129 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.434464e-01 0.129 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 7.434464e-01 0.129 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 7.434464e-01 0.129 0 0
Activation of TRKA receptors R-HSA-187015 7.434464e-01 0.129 0 0
Glycoprotein hormones R-HSA-209822 7.434464e-01 0.129 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 7.434464e-01 0.129 0 0
Gastrulation R-HSA-9758941 7.449795e-01 0.128 0 0
Hedgehog 'on' state R-HSA-5632684 7.451262e-01 0.128 0 0
HIV Life Cycle R-HSA-162587 7.460115e-01 0.127 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.481427e-01 0.126 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 7.515196e-01 0.124 0 0
Translesion synthesis by POLI R-HSA-5656121 7.551356e-01 0.122 0 0
Killing mechanisms R-HSA-9664420 7.551356e-01 0.122 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 7.551356e-01 0.122 0 0
Regulation of BACH1 activity R-HSA-9708530 7.551356e-01 0.122 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 7.551356e-01 0.122 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 7.551356e-01 0.122 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 7.568328e-01 0.121 0 0
HIV Infection R-HSA-162906 7.573005e-01 0.121 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 7.578391e-01 0.120 0 0
DNA strand elongation R-HSA-69190 7.581026e-01 0.120 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.581026e-01 0.120 0 0
Insulin receptor signalling cascade R-HSA-74751 7.610514e-01 0.119 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.644039e-01 0.117 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.644039e-01 0.117 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.644039e-01 0.117 0 0
Diseases of Immune System R-HSA-5260271 7.644039e-01 0.117 0 0
Glycogen metabolism R-HSA-8982491 7.644039e-01 0.117 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 7.644039e-01 0.117 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 7.644039e-01 0.117 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 7.654496e-01 0.116 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.654496e-01 0.116 0 0
Signaling by EGFR R-HSA-177929 7.654496e-01 0.116 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 7.736566e-01 0.111 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 7.736566e-01 0.111 0 0
TNFs bind their physiological receptors R-HSA-5669034 7.736566e-01 0.111 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 7.743445e-01 0.111 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 7.754283e-01 0.110 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.760888e-01 0.110 0 0
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597 7.760888e-01 0.110 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.760888e-01 0.110 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.760888e-01 0.110 0 0
Interleukin-9 signaling R-HSA-8985947 7.760888e-01 0.110 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 7.760888e-01 0.110 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 7.760888e-01 0.110 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.760888e-01 0.110 0 0
Nucleotide salvage defects R-HSA-9734207 7.760888e-01 0.110 0 0
Alpha-defensins R-HSA-1462054 7.760888e-01 0.110 0 0
Translesion synthesis by POLK R-HSA-5655862 7.784837e-01 0.109 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 7.784837e-01 0.109 0 0
Passive transport by Aquaporins R-HSA-432047 7.784837e-01 0.109 0 0
Synthesis of PG R-HSA-1483148 7.784837e-01 0.109 0 0
Regulation of CDH1 Function R-HSA-9764561 7.788020e-01 0.109 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 7.798571e-01 0.108 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 7.798571e-01 0.108 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 7.798571e-01 0.108 0 0
Signaling by NOTCH4 R-HSA-9013694 7.819136e-01 0.107 0 0
SARS-CoV-2 Infection R-HSA-9694516 7.893497e-01 0.103 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 7.896696e-01 0.103 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.896696e-01 0.103 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 7.917592e-01 0.101 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 7.917592e-01 0.101 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 7.917592e-01 0.101 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.917592e-01 0.101 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.921473e-01 0.101 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.921473e-01 0.101 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 7.932791e-01 0.101 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 7.945163e-01 0.100 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 7.945163e-01 0.100 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.945163e-01 0.100 0 0
Intra-Golgi traffic R-HSA-6811438 7.945163e-01 0.100 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.987124e-01 0.098 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 7.998564e-01 0.097 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 7.998564e-01 0.097 0 0
Uptake and function of anthrax toxins R-HSA-5210891 7.998564e-01 0.097 0 0
Triglyceride metabolism R-HSA-8979227 8.037976e-01 0.095 0 0
Regulation of beta-cell development R-HSA-186712 8.037976e-01 0.095 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.041183e-01 0.095 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 8.045797e-01 0.094 0 0
Interleukin-21 signaling R-HSA-9020958 8.045797e-01 0.094 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 8.045797e-01 0.094 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 8.045797e-01 0.094 0 0
Unwinding of DNA R-HSA-176974 8.045797e-01 0.094 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 8.045797e-01 0.094 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 8.045797e-01 0.094 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 8.045797e-01 0.094 0 0
Lysosomal oligosaccharide catabolism R-HSA-8853383 8.045797e-01 0.094 0 0
Cellular response to mitochondrial stress R-HSA-9840373 8.045797e-01 0.094 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 8.045797e-01 0.094 0 0
GP1b-IX-V activation signalling R-HSA-430116 8.045797e-01 0.094 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.071225e-01 0.093 0 0
Mitophagy R-HSA-5205647 8.071225e-01 0.093 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 8.071225e-01 0.093 0 0
Signaling by NOTCH2 R-HSA-1980145 8.071225e-01 0.093 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 8.091711e-01 0.092 0 0
Signaling by EGFR in Cancer R-HSA-1643713 8.093614e-01 0.092 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 8.093614e-01 0.092 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.093614e-01 0.092 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 8.093614e-01 0.092 0 0
HCMV Late Events R-HSA-9610379 8.105408e-01 0.091 0 0
Platelet homeostasis R-HSA-418346 8.110020e-01 0.091 0 0
GABA receptor activation R-HSA-977443 8.154571e-01 0.089 0 0
Potential therapeutics for SARS R-HSA-9679191 8.185571e-01 0.087 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 8.193784e-01 0.087 0 0
GAB1 signalosome R-HSA-180292 8.193784e-01 0.087 0 0
Tie2 Signaling R-HSA-210993 8.193784e-01 0.087 0 0
Platelet sensitization by LDL R-HSA-432142 8.193784e-01 0.087 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 8.194901e-01 0.086 0 0
Synthesis of DNA R-HSA-69239 8.197424e-01 0.086 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 8.215234e-01 0.085 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.234904e-01 0.084 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.253547e-01 0.083 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 8.253547e-01 0.083 0 0
Insulin processing R-HSA-264876 8.253547e-01 0.083 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.281375e-01 0.082 0 0
2-LTR circle formation R-HSA-164843 8.294467e-01 0.081 0 0
DNA replication initiation R-HSA-68952 8.294467e-01 0.081 0 0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 8.294467e-01 0.081 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.294467e-01 0.081 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 8.294467e-01 0.081 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.294467e-01 0.081 0 0
Pexophagy R-HSA-9664873 8.294467e-01 0.081 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 8.294467e-01 0.081 0 0
Maturation of spike protein R-HSA-9683686 8.294467e-01 0.081 0 0
Sperm Motility And Taxes R-HSA-1300642 8.294467e-01 0.081 0 0
Peptide hormone biosynthesis R-HSA-209952 8.294467e-01 0.081 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.294467e-01 0.081 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 8.296199e-01 0.081 0 0
DAP12 interactions R-HSA-2172127 8.339128e-01 0.079 0 0
Smooth Muscle Contraction R-HSA-445355 8.349083e-01 0.078 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.350723e-01 0.078 0 0
RNA Polymerase III Transcription R-HSA-74158 8.350723e-01 0.078 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.350723e-01 0.078 0 0
RUNX2 regulates bone development R-HSA-8941326 8.350723e-01 0.078 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.354010e-01 0.078 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 8.371745e-01 0.077 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 8.371745e-01 0.077 0 0
Regulation of signaling by CBL R-HSA-912631 8.371745e-01 0.077 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 8.371745e-01 0.077 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 8.371745e-01 0.077 0 0
Other interleukin signaling R-HSA-449836 8.371745e-01 0.077 0 0
Maturation of nucleoprotein R-HSA-9694631 8.371745e-01 0.077 0 0
Host Interactions of HIV factors R-HSA-162909 8.390844e-01 0.076 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 8.393757e-01 0.076 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.401422e-01 0.076 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.401854e-01 0.076 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 8.401854e-01 0.076 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.401854e-01 0.076 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 8.401854e-01 0.076 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 8.401854e-01 0.076 0 0
Pyrimidine salvage R-HSA-73614 8.401854e-01 0.076 0 0
PKR-mediated signaling R-HSA-9833482 8.435808e-01 0.074 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 8.435808e-01 0.074 0 0
Leishmania infection R-HSA-9658195 8.454877e-01 0.073 0 0
Parasitic Infection Pathways R-HSA-9824443 8.454877e-01 0.073 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 8.472126e-01 0.072 0 0
Degradation of DVL R-HSA-4641258 8.477277e-01 0.072 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 8.511507e-01 0.070 0 0
FGFR2b ligand binding and activation R-HSA-190377 8.511507e-01 0.070 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 8.511507e-01 0.070 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.511507e-01 0.070 0 0
vRNP Assembly R-HSA-192905 8.511507e-01 0.070 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.511507e-01 0.070 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 8.511507e-01 0.070 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.511507e-01 0.070 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.511507e-01 0.070 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 8.511507e-01 0.070 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 8.511507e-01 0.070 0 0
Suppression of apoptosis R-HSA-9635465 8.511507e-01 0.070 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 8.533677e-01 0.069 0 0
Signaling by NODAL R-HSA-1181150 8.533677e-01 0.069 0 0
mRNA Capping R-HSA-72086 8.539136e-01 0.069 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.539136e-01 0.069 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 8.539136e-01 0.069 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 8.559562e-01 0.068 0 0
COPI-mediated anterograde transport R-HSA-6807878 8.589332e-01 0.066 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.665996e-01 0.062 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.665996e-01 0.062 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 8.669088e-01 0.062 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 8.680777e-01 0.061 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.680777e-01 0.061 0 0
Signalling to RAS R-HSA-167044 8.680777e-01 0.061 0 0
Basigin interactions R-HSA-210991 8.680777e-01 0.061 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 8.680777e-01 0.061 0 0
Nucleotide Excision Repair R-HSA-5696398 8.694912e-01 0.061 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.700939e-01 0.060 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.700939e-01 0.060 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 8.700939e-01 0.060 0 0
Plasmalogen biosynthesis R-HSA-75896 8.700939e-01 0.060 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.700939e-01 0.060 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.700939e-01 0.060 0 0
Integration of provirus R-HSA-162592 8.700939e-01 0.060 0 0
Uptake of dietary cobalamins into enterocytes R-HSA-9758881 8.700939e-01 0.060 0 0
Stabilization of p53 R-HSA-69541 8.705829e-01 0.060 0 0
Signaling by ALK R-HSA-201556 8.705829e-01 0.060 0 0
SARS-CoV Infections R-HSA-9679506 8.723452e-01 0.059 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 8.764491e-01 0.057 0 0
Cargo concentration in the ER R-HSA-5694530 8.783038e-01 0.056 0 0
Budding and maturation of HIV virion R-HSA-162588 8.783038e-01 0.056 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 8.783038e-01 0.056 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.783038e-01 0.056 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.783038e-01 0.056 0 0
Clathrin-mediated endocytosis R-HSA-8856828 8.799431e-01 0.056 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.808587e-01 0.055 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 8.814197e-01 0.055 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.814197e-01 0.055 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 8.814197e-01 0.055 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 8.814197e-01 0.055 0 0
Dual incision in TC-NER R-HSA-6782135 8.833428e-01 0.054 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.833428e-01 0.054 0 0
Degradation of CDH1 R-HSA-9766229 8.856894e-01 0.053 0 0
MET activates RAS signaling R-HSA-8851805 8.866272e-01 0.052 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.866272e-01 0.052 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.866272e-01 0.052 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 8.866272e-01 0.052 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 8.866272e-01 0.052 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.866272e-01 0.052 0 0
Estrogen biosynthesis R-HSA-193144 8.866272e-01 0.052 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.866272e-01 0.052 0 0
OAS antiviral response R-HSA-8983711 8.866272e-01 0.052 0 0
HCMV Infection R-HSA-9609646 8.879957e-01 0.052 0 0
Maturation of spike protein R-HSA-9694548 8.904177e-01 0.050 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.933688e-01 0.049 0 0
Notch-HLH transcription pathway R-HSA-350054 8.935036e-01 0.049 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.935036e-01 0.049 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 8.935036e-01 0.049 0 0
Signaling by KIT in disease R-HSA-9669938 8.935036e-01 0.049 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 8.935036e-01 0.049 0 0
Regulation of RAS by GAPs R-HSA-5658442 8.941957e-01 0.049 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.941957e-01 0.049 0 0
PCP/CE pathway R-HSA-4086400 8.969684e-01 0.047 0 0
PPARA activates gene expression R-HSA-1989781 8.985114e-01 0.046 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 8.990047e-01 0.046 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.990047e-01 0.046 0 0
FGFR2c ligand binding and activation R-HSA-190375 9.010571e-01 0.045 0 0
FGFR1c ligand binding and activation R-HSA-190373 9.010571e-01 0.045 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 9.010571e-01 0.045 0 0
FGFR4 ligand binding and activation R-HSA-190322 9.010571e-01 0.045 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 9.010571e-01 0.045 0 0
Chylomicron remodeling R-HSA-8963901 9.010571e-01 0.045 0 0
Mtb iron assimilation by chelation R-HSA-1222449 9.010571e-01 0.045 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 9.010571e-01 0.045 0 0
FGFR3 mutant receptor activation R-HSA-2033514 9.010571e-01 0.045 0 0
Diseases of nucleotide metabolism R-HSA-9735804 9.010571e-01 0.045 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 9.010571e-01 0.045 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.034487e-01 0.044 0 0
COPII-mediated vesicle transport R-HSA-204005 9.043206e-01 0.044 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.044333e-01 0.044 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.044333e-01 0.044 0 0
Formation of the ureteric bud R-HSA-9830674 9.044333e-01 0.044 0 0
Carnitine shuttle R-HSA-200425 9.044333e-01 0.044 0 0
Growth hormone receptor signaling R-HSA-982772 9.044333e-01 0.044 0 0
Viral Messenger RNA Synthesis R-HSA-168325 9.061942e-01 0.043 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.061942e-01 0.043 0 0
Activation of GABAB receptors R-HSA-991365 9.075374e-01 0.042 0 0
GABA B receptor activation R-HSA-977444 9.075374e-01 0.042 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.075374e-01 0.042 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.077267e-01 0.042 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.081164e-01 0.042 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.095768e-01 0.041 0 0
Inositol phosphate metabolism R-HSA-1483249 9.112202e-01 0.040 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.129007e-01 0.040 0 0
Signaling by PDGF R-HSA-186797 9.129007e-01 0.040 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 9.136512e-01 0.039 0 0
CRMPs in Sema3A signaling R-HSA-399956 9.136512e-01 0.039 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 9.136512e-01 0.039 0 0
FGFR3c ligand binding and activation R-HSA-190372 9.136512e-01 0.039 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 9.136512e-01 0.039 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 9.136512e-01 0.039 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 9.136512e-01 0.039 0 0
Prolactin receptor signaling R-HSA-1170546 9.136512e-01 0.039 0 0
Glycerophospholipid catabolism R-HSA-6814848 9.136512e-01 0.039 0 0
Malate-aspartate shuttle R-HSA-9856872 9.136512e-01 0.039 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.136512e-01 0.039 0 0
Non-canonical inflammasome activation R-HSA-9686114 9.136512e-01 0.039 0 0
Ciprofloxacin ADME R-HSA-9793528 9.136512e-01 0.039 0 0
Signal regulatory protein family interactions R-HSA-391160 9.136512e-01 0.039 0 0
P2Y receptors R-HSA-417957 9.136512e-01 0.039 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.143070e-01 0.039 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.143070e-01 0.039 0 0
Signaling by FGFR4 R-HSA-5654743 9.151724e-01 0.038 0 0
RSV-host interactions R-HSA-9833110 9.154084e-01 0.038 0 0
Dual Incision in GG-NER R-HSA-5696400 9.164762e-01 0.038 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.164762e-01 0.038 0 0
eNOS activation R-HSA-203615 9.164762e-01 0.038 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 9.164762e-01 0.038 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.165057e-01 0.038 0 0
Neurotransmitter release cycle R-HSA-112310 9.202822e-01 0.036 0 0
Surfactant metabolism R-HSA-5683826 9.222392e-01 0.035 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.229621e-01 0.035 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.232162e-01 0.035 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.232162e-01 0.035 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.232162e-01 0.035 0 0
G protein gated Potassium channels R-HSA-1296059 9.232162e-01 0.035 0 0
Laminin interactions R-HSA-3000157 9.232162e-01 0.035 0 0
Hyaluronan degradation R-HSA-2160916 9.232162e-01 0.035 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.241366e-01 0.034 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.241366e-01 0.034 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.246428e-01 0.034 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 9.246428e-01 0.034 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.246428e-01 0.034 0 0
Protein lipoylation R-HSA-9857492 9.246428e-01 0.034 0 0
Signaling by Activin R-HSA-1502540 9.246428e-01 0.034 0 0
p38MAPK events R-HSA-171007 9.246428e-01 0.034 0 0
Biotin transport and metabolism R-HSA-196780 9.246428e-01 0.034 0 0
FGFR3 ligand binding and activation R-HSA-190239 9.246428e-01 0.034 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 9.246428e-01 0.034 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 9.246428e-01 0.034 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.246428e-01 0.034 0 0
Spry regulation of FGF signaling R-HSA-1295596 9.246428e-01 0.034 0 0
Other semaphorin interactions R-HSA-416700 9.246428e-01 0.034 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 9.246428e-01 0.034 0 0
DNA Damage Reversal R-HSA-73942 9.246428e-01 0.034 0 0
Ion transport by P-type ATPases R-HSA-936837 9.250720e-01 0.034 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.287725e-01 0.032 0 0
Signaling by FGFR3 R-HSA-5654741 9.287725e-01 0.032 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.296040e-01 0.032 0 0
Cellular response to hypoxia R-HSA-1234174 9.305773e-01 0.031 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.311479e-01 0.031 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.311479e-01 0.031 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.311479e-01 0.031 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 9.312466e-01 0.031 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 9.312466e-01 0.031 0 0
Abacavir ADME R-HSA-2161522 9.312466e-01 0.031 0 0
G alpha (s) signalling events R-HSA-418555 9.326549e-01 0.030 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.329607e-01 0.030 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.342359e-01 0.030 0 0
Activation of SMO R-HSA-5635838 9.342359e-01 0.030 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 9.342359e-01 0.030 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 9.342359e-01 0.030 0 0
Fructose catabolism R-HSA-70350 9.342359e-01 0.030 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 9.342359e-01 0.030 0 0
Atorvastatin ADME R-HSA-9754706 9.342359e-01 0.030 0 0
Protein folding R-HSA-391251 9.345371e-01 0.029 0 0
Signaling by Insulin receptor R-HSA-74752 9.345371e-01 0.029 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.348061e-01 0.029 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.348061e-01 0.029 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.348061e-01 0.029 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.375580e-01 0.028 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.384773e-01 0.028 0 0
Signaling by BMP R-HSA-201451 9.384773e-01 0.028 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.384773e-01 0.028 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.403721e-01 0.027 0 0
Kidney development R-HSA-9830369 9.405253e-01 0.027 0 0
Glycine degradation R-HSA-6783984 9.426082e-01 0.026 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.426082e-01 0.026 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.426082e-01 0.026 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.426082e-01 0.026 0 0
Coenzyme A biosynthesis R-HSA-196783 9.426082e-01 0.026 0 0
Response to metal ions R-HSA-5660526 9.426082e-01 0.026 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.434122e-01 0.025 0 0
XBP1(S) activates chaperone genes R-HSA-381038 9.441870e-01 0.025 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.449819e-01 0.025 0 0
Intraflagellar transport R-HSA-5620924 9.455017e-01 0.024 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 9.489878e-01 0.023 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.490353e-01 0.023 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.499151e-01 0.022 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.499151e-01 0.022 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 9.499151e-01 0.022 0 0
Glycogen storage diseases R-HSA-3229121 9.499151e-01 0.022 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.499151e-01 0.022 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.499151e-01 0.022 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.499151e-01 0.022 0 0
Choline catabolism R-HSA-6798163 9.499151e-01 0.022 0 0
Gap junction trafficking and regulation R-HSA-157858 9.502245e-01 0.022 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.508280e-01 0.022 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.508280e-01 0.022 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.536213e-01 0.021 0 0
Signaling by FGFR2 R-HSA-5654738 9.537767e-01 0.021 0 0
Neurotransmitter clearance R-HSA-112311 9.560777e-01 0.020 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.562920e-01 0.019 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.562920e-01 0.019 0 0
Activated point mutants of FGFR2 R-HSA-2033519 9.562920e-01 0.019 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.562920e-01 0.019 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.562920e-01 0.019 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.562920e-01 0.019 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.562920e-01 0.019 0 0
Transport of connexons to the plasma membrane R-HSA-190872 9.562920e-01 0.019 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.562920e-01 0.019 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.562920e-01 0.019 0 0
Collagen degradation R-HSA-1442490 9.570019e-01 0.019 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.579409e-01 0.019 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.580542e-01 0.019 0 0
The phototransduction cascade R-HSA-2514856 9.585604e-01 0.018 0 0
Mitochondrial protein import R-HSA-1268020 9.605427e-01 0.017 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.605427e-01 0.017 0 0
tRNA processing in the nucleus R-HSA-6784531 9.605427e-01 0.017 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.607882e-01 0.017 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.607882e-01 0.017 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.611240e-01 0.017 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.618574e-01 0.017 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.618574e-01 0.017 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.620872e-01 0.017 0 0
Translation of Structural Proteins R-HSA-9683701 9.620872e-01 0.017 0 0
IRE1alpha activates chaperones R-HSA-381070 9.638916e-01 0.016 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.655880e-01 0.015 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.667144e-01 0.015 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 9.667144e-01 0.015 0 0
Glycogen synthesis R-HSA-3322077 9.667144e-01 0.015 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.667144e-01 0.015 0 0
Pregnenolone biosynthesis R-HSA-196108 9.667144e-01 0.015 0 0
Interferon gamma signaling R-HSA-877300 9.673401e-01 0.014 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.686420e-01 0.014 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.709531e-01 0.013 0 0
G-protein activation R-HSA-202040 9.709531e-01 0.013 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 9.709531e-01 0.013 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.709531e-01 0.013 0 0
Phenylalanine metabolism R-HSA-8964208 9.709531e-01 0.013 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.709531e-01 0.013 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.709531e-01 0.013 0 0
Early Phase of HIV Life Cycle R-HSA-162594 9.709531e-01 0.013 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.709787e-01 0.013 0 0
Interferon Signaling R-HSA-913531 9.710072e-01 0.013 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.711496e-01 0.013 0 0
Mitochondrial protein degradation R-HSA-9837999 9.711683e-01 0.013 0 0
Collagen formation R-HSA-1474290 9.711683e-01 0.013 0 0
UCH proteinases R-HSA-5689603 9.712514e-01 0.013 0 0
G alpha (z) signalling events R-HSA-418597 9.714926e-01 0.013 0 0
Viral Infection Pathways R-HSA-9824446 9.720370e-01 0.012 0 0
Gap junction trafficking R-HSA-190828 9.721048e-01 0.012 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.721834e-01 0.012 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.721834e-01 0.012 0 0
Heme degradation R-HSA-189483 9.721834e-01 0.012 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.721877e-01 0.012 0 0
Translation of Structural Proteins R-HSA-9694635 9.735588e-01 0.012 0 0
Signaling by FGFR1 R-HSA-5654736 9.740757e-01 0.011 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.740757e-01 0.011 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.746523e-01 0.011 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.746523e-01 0.011 0 0
Assembly Of The HIV Virion R-HSA-175474 9.746523e-01 0.011 0 0
Glutathione synthesis and recycling R-HSA-174403 9.746523e-01 0.011 0 0
Hyaluronan metabolism R-HSA-2142845 9.752147e-01 0.011 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.776687e-01 0.010 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.778806e-01 0.010 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.778806e-01 0.010 0 0
Fructose metabolism R-HSA-5652084 9.778806e-01 0.010 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.778806e-01 0.010 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.778806e-01 0.010 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.779253e-01 0.010 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.779253e-01 0.010 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.779253e-01 0.010 0 0
Signaling by MET R-HSA-6806834 9.794936e-01 0.009 0 0
Leishmania phagocytosis R-HSA-9664417 9.797071e-01 0.009 0 0
Parasite infection R-HSA-9664407 9.797071e-01 0.009 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.797071e-01 0.009 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.806979e-01 0.008 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.806979e-01 0.008 0 0
Biosynthesis of maresins R-HSA-9018682 9.806979e-01 0.008 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.806979e-01 0.008 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.807146e-01 0.008 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.816448e-01 0.008 0 0
tRNA Aminoacylation R-HSA-379724 9.823665e-01 0.008 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.823665e-01 0.008 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.825114e-01 0.008 0 0
Degradation of AXIN R-HSA-4641257 9.825114e-01 0.008 0 0
Lysine catabolism R-HSA-71064 9.825114e-01 0.008 0 0
Collagen chain trimerization R-HSA-8948216 9.825114e-01 0.008 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.831565e-01 0.007 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.831565e-01 0.007 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.831565e-01 0.007 0 0
Innate Immune System R-HSA-168249 9.833458e-01 0.007 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.840068e-01 0.007 0 0
Nucleotide salvage R-HSA-8956321 9.840068e-01 0.007 0 0
Phospholipid metabolism R-HSA-1483257 9.843504e-01 0.007 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.848495e-01 0.007 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.853021e-01 0.006 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.853021e-01 0.006 0 0
Fertilization R-HSA-1187000 9.853021e-01 0.006 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.853021e-01 0.006 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.853021e-01 0.006 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.861662e-01 0.006 0 0
Pentose phosphate pathway R-HSA-71336 9.861662e-01 0.006 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.865390e-01 0.006 0 0
Hemostasis R-HSA-109582 9.866108e-01 0.006 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.866172e-01 0.006 0 0
MET activates PTK2 signaling R-HSA-8874081 9.871744e-01 0.006 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.871744e-01 0.006 0 0
Urea cycle R-HSA-70635 9.871744e-01 0.006 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.877030e-01 0.005 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.877338e-01 0.005 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.879731e-01 0.005 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.888084e-01 0.005 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.888084e-01 0.005 0 0
Triglyceride biosynthesis R-HSA-75109 9.888084e-01 0.005 0 0
Synthesis of PE R-HSA-1483213 9.888084e-01 0.005 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.888084e-01 0.005 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.888084e-01 0.005 0 0
SLC transporter disorders R-HSA-5619102 9.888665e-01 0.005 0 0
Neddylation R-HSA-8951664 9.889588e-01 0.005 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.890729e-01 0.005 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.901615e-01 0.004 0 0
Prednisone ADME R-HSA-9757110 9.902342e-01 0.004 0 0
Insulin receptor recycling R-HSA-77387 9.902342e-01 0.004 0 0
Integrin cell surface interactions R-HSA-216083 9.907442e-01 0.004 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.911855e-01 0.004 0 0
Nicotinate metabolism R-HSA-196807 9.911855e-01 0.004 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.913804e-01 0.004 0 0
Thyroxine biosynthesis R-HSA-209968 9.914785e-01 0.004 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.914785e-01 0.004 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.914785e-01 0.004 0 0
Glucagon-type ligand receptors R-HSA-420092 9.914785e-01 0.004 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.914785e-01 0.004 0 0
ER-Phagosome pathway R-HSA-1236974 9.914861e-01 0.004 0 0
Signaling by FGFR R-HSA-190236 9.916295e-01 0.004 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.919272e-01 0.004 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.920311e-01 0.003 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.921882e-01 0.003 0 0
Protein localization R-HSA-9609507 9.922550e-01 0.003 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.923481e-01 0.003 0 0
G alpha (q) signalling events R-HSA-416476 9.924195e-01 0.003 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.925643e-01 0.003 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.927208e-01 0.003 0 0
Platelet degranulation R-HSA-114608 9.927679e-01 0.003 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.935118e-01 0.003 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.935118e-01 0.003 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.935118e-01 0.003 0 0
GPCR downstream signalling R-HSA-388396 9.939618e-01 0.003 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.939751e-01 0.003 0 0
Somitogenesis R-HSA-9824272 9.939751e-01 0.003 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.940837e-01 0.003 0 0
Metabolism of cofactors R-HSA-8978934 9.941262e-01 0.003 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.943386e-01 0.002 0 0
Peroxisomal protein import R-HSA-9033241 9.943713e-01 0.002 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.943713e-01 0.002 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.949575e-01 0.002 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.950601e-01 0.002 0 0
Recycling of bile acids and salts R-HSA-159418 9.950601e-01 0.002 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.952616e-01 0.002 0 0
Synthesis of PC R-HSA-1483191 9.952616e-01 0.002 0 0
Iron uptake and transport R-HSA-917937 9.961102e-01 0.002 0 0
Interferon alpha/beta signaling R-HSA-909733 9.962366e-01 0.002 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.962391e-01 0.002 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.962391e-01 0.002 0 0
Gap junction assembly R-HSA-190861 9.962391e-01 0.002 0 0
Signal amplification R-HSA-392518 9.962391e-01 0.002 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.962391e-01 0.002 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.962391e-01 0.002 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.962391e-01 0.002 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.962773e-01 0.002 0 0
Azathioprine ADME R-HSA-9748787 9.967016e-01 0.001 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.967185e-01 0.001 0 0
PERK regulates gene expression R-HSA-381042 9.967185e-01 0.001 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.967185e-01 0.001 0 0
Regulation of Apoptosis R-HSA-169911 9.967185e-01 0.001 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.967185e-01 0.001 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.967185e-01 0.001 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.970782e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.970782e-01 0.001 0 0
Glycosphingolipid transport R-HSA-9845576 9.971368e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.971554e-01 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 9.971554e-01 0.001 0 0
Cholesterol biosynthesis R-HSA-191273 9.971554e-01 0.001 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.975018e-01 0.001 0 0
NCAM1 interactions R-HSA-419037 9.975018e-01 0.001 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.975018e-01 0.001 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.975018e-01 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 9.977090e-01 0.001 0 0
Elastic fibre formation R-HSA-1566948 9.978202e-01 0.001 0 0
Purine salvage R-HSA-74217 9.978202e-01 0.001 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.980982e-01 0.001 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.980982e-01 0.001 0 0
RAS processing R-HSA-9648002 9.980982e-01 0.001 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.980982e-01 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 9.982958e-01 0.001 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.983406e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.983511e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.983897e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.983897e-01 0.001 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.985522e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.985951e-01 0.001 0 0
Purine catabolism R-HSA-74259 9.986861e-01 0.001 0 0
Heme biosynthesis R-HSA-189451 9.987368e-01 0.001 0 0
Peptide hormone metabolism R-HSA-2980736 9.988544e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.989069e-01 0.000 0 0
Pyrimidine catabolism R-HSA-73621 9.990385e-01 0.000 0 0
Defensins R-HSA-1461973 9.990385e-01 0.000 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.990385e-01 0.000 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.990771e-01 0.000 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.991611e-01 0.000 0 0
Proteasome assembly R-HSA-9907900 9.991611e-01 0.000 0 0
Methylation R-HSA-156581 9.991611e-01 0.000 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.991611e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.991614e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.992111e-01 0.000 0 0
ABC-family proteins mediated transport R-HSA-382556 9.992259e-01 0.000 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.992681e-01 0.000 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.993615e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.994411e-01 0.000 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.995140e-01 0.000 0 0
Gluconeogenesis R-HSA-70263 9.995140e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.995631e-01 0.000 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.995760e-01 0.000 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.995760e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.995797e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.995917e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.995917e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.996156e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.996301e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.996390e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.997053e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.997521e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.997521e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.997639e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.997937e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.998070e-01 0.000 0 0
Paracetamol ADME R-HSA-9753281 9.998131e-01 0.000 0 0
Digestion R-HSA-8935690 9.998369e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.998577e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.998624e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.998650e-01 0.000 0 0
tRNA processing R-HSA-72306 9.998700e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.998922e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.999056e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.999056e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999092e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.999176e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999288e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999373e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999388e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999439e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.999453e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999523e-01 0.000 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.999559e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.999565e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999670e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.999683e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999744e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.999790e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999790e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.999817e-01 0.000 0 0
Translation R-HSA-72766 9.999876e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999878e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999919e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999946e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999946e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.999950e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999951e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999964e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999977e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999979e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999986e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999988e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999990e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999991e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999991e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999994e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999994e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999994e-01 0.000 0 0
Disease R-HSA-1643685 9.999995e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999996e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999996e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999997e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999997e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999998e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999998e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999998e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 4.115042e-12 11.386 0 0
HSF1-dependent transactivation R-HSA-3371571 5.506040e-12 11.259 0 0
Attenuation phase R-HSA-3371568 1.189793e-11 10.925 0 0
Cellular response to heat stress R-HSA-3371556 1.333911e-11 10.875 0 0
Apoptotic execution phase R-HSA-75153 1.728631e-10 9.762 0 0
Chromatin organization R-HSA-4839726 4.516231e-10 9.345 0 0
HSF1 activation R-HSA-3371511 6.011877e-10 9.221 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.425443e-09 8.846 0 0
Cell Cycle, Mitotic R-HSA-69278 1.853367e-09 8.732 0 0
Cellular responses to stress R-HSA-2262752 2.701223e-09 8.568 0 0
Chromatin modifying enzymes R-HSA-3247509 3.469714e-09 8.460 0 0
Cellular responses to stimuli R-HSA-8953897 4.082138e-09 8.389 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.060514e-08 7.974 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.235332e-08 7.908 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.464888e-08 7.834 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.983378e-08 7.703 0 0
Cell Cycle Checkpoints R-HSA-69620 2.353643e-08 7.628 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 3.264240e-08 7.486 0 0
Meiotic synapsis R-HSA-1221632 3.906129e-08 7.408 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.906129e-08 7.408 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 5.433970e-08 7.265 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 5.800168e-08 7.237 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 8.545784e-08 7.068 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 8.875726e-08 7.052 0 0
M Phase R-HSA-68886 1.021507e-07 6.991 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.387943e-07 6.858 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.620211e-07 6.790 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.190097e-07 6.660 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.115786e-07 6.675 0 0
Meiosis R-HSA-1500620 2.229033e-07 6.652 0 0
HDACs deacetylate histones R-HSA-3214815 2.878539e-07 6.541 0 0
Cell-Cell communication R-HSA-1500931 2.851808e-07 6.545 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.486975e-07 6.458 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.819956e-07 6.418 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 6.396491e-07 6.194 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.194412e-06 5.923 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.193013e-06 5.923 0 0
DNA methylation R-HSA-5334118 1.262270e-06 5.899 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 1.264010e-06 5.898 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.418585e-06 5.848 0 0
Nucleosome assembly R-HSA-774815 1.904015e-06 5.720 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.904015e-06 5.720 0 0
Mitotic Prophase R-HSA-68875 1.938084e-06 5.713 0 0
G2/M Checkpoints R-HSA-69481 2.085417e-06 5.681 0 0
Chromosome Maintenance R-HSA-73886 2.233159e-06 5.651 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.338666e-06 5.631 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 2.432969e-06 5.614 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.794037e-06 5.554 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 3.216919e-06 5.493 0 0
Packaging Of Telomere Ends R-HSA-171306 3.519820e-06 5.453 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 3.669930e-06 5.435 0 0
HATs acetylate histones R-HSA-3214847 4.236604e-06 5.373 0 0
Processing of DNA double-strand break ends R-HSA-5693607 4.334199e-06 5.363 0 0
Cell junction organization R-HSA-446728 4.843044e-06 5.315 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.990807e-06 5.223 0 0
Cellular Senescence R-HSA-2559583 6.667265e-06 5.176 0 0
Meiotic recombination R-HSA-912446 7.627379e-06 5.118 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 7.593991e-06 5.120 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 7.593991e-06 5.120 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 7.513210e-06 5.124 0 0
RNA Polymerase I Transcription R-HSA-73864 8.483536e-06 5.071 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 8.483536e-06 5.071 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.440181e-06 5.025 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.057924e-05 4.976 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.078212e-05 4.967 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.134855e-05 4.945 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.196729e-05 4.922 0 0
DNA Double Strand Break Response R-HSA-5693606 1.361723e-05 4.866 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.441731e-05 4.841 0 0
mRNA Splicing R-HSA-72172 1.530463e-05 4.815 0 0
Cleavage of the damaged purine R-HSA-110331 1.628118e-05 4.788 0 0
Defective pyroptosis R-HSA-9710421 2.029445e-05 4.693 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.053759e-05 4.687 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.140489e-05 4.669 0 0
Depurination R-HSA-73927 2.075784e-05 4.683 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.306395e-05 4.637 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.307159e-05 4.637 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.698401e-05 4.569 0 0
Telomere Maintenance R-HSA-157579 2.731448e-05 4.564 0 0
Homology Directed Repair R-HSA-5693538 3.108870e-05 4.507 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.226236e-05 4.491 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.296745e-05 4.482 0 0
Nervous system development R-HSA-9675108 3.712019e-05 4.430 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 4.132762e-05 4.384 0 0
Axon guidance R-HSA-422475 4.333487e-05 4.363 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.936257e-05 4.307 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.936257e-05 4.307 0 0
Reproduction R-HSA-1474165 6.296523e-05 4.201 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 6.342821e-05 4.198 0 0
Depyrimidination R-HSA-73928 6.342821e-05 4.198 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 6.741570e-05 4.171 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 7.819054e-05 4.107 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 8.599217e-05 4.066 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.083968e-04 3.965 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.103855e-04 3.957 0 0
Adherens junctions interactions R-HSA-418990 1.140260e-04 3.943 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.153373e-04 3.938 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.441807e-04 3.841 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.490972e-04 3.827 0 0
Apoptosis R-HSA-109581 1.552396e-04 3.809 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.659877e-04 3.780 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.724643e-04 3.763 0 0
Mitotic Anaphase R-HSA-68882 1.997327e-04 3.700 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.104553e-04 3.677 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.160066e-04 3.666 0 0
Activation of RAC1 R-HSA-428540 2.279906e-04 3.642 0 0
Mitotic Prometaphase R-HSA-68877 2.540524e-04 3.595 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.753332e-04 3.560 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.807707e-04 3.552 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.807707e-04 3.552 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.888491e-04 3.539 0 0
Signaling by ALK in cancer R-HSA-9700206 2.888491e-04 3.539 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.507284e-04 3.455 0 0
Cell-cell junction organization R-HSA-421270 3.457771e-04 3.461 0 0
Diseases of programmed cell death R-HSA-9645723 3.658878e-04 3.437 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.664186e-04 3.436 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 4.058391e-04 3.392 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 5.246546e-04 3.280 0 0
Signaling by ROBO receptors R-HSA-376176 5.566070e-04 3.254 0 0
PKMTs methylate histone lysines R-HSA-3214841 5.590128e-04 3.253 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 6.072949e-04 3.217 0 0
Amplification of signal from the kinetochores R-HSA-141424 6.654183e-04 3.177 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 6.654183e-04 3.177 0 0
Metabolism of RNA R-HSA-8953854 6.626129e-04 3.179 0 0
Gene Silencing by RNA R-HSA-211000 7.031773e-04 3.153 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 8.306104e-04 3.081 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 8.977610e-04 3.047 0 0
ESR-mediated signaling R-HSA-8939211 9.122515e-04 3.040 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 9.400566e-04 3.027 0 0
Signal Transduction R-HSA-162582 9.909514e-04 3.004 1 0
Signaling by VEGF R-HSA-194138 1.034419e-03 2.985 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.319101e-03 2.880 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.319101e-03 2.880 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.224431e-03 2.912 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.386433e-03 2.858 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 1.386433e-03 2.858 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.505699e-03 2.822 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.506874e-03 2.822 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.506874e-03 2.822 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.506874e-03 2.822 0 0
Signaling by RAS mutants R-HSA-6802949 1.506874e-03 2.822 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.620695e-03 2.790 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.726572e-03 2.763 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.912178e-03 2.718 0 0
RAF activation R-HSA-5673000 1.867922e-03 2.729 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.979141e-03 2.704 0 0
DNA Repair R-HSA-73894 2.133230e-03 2.671 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.152102e-03 2.667 0 0
Amyloid fiber formation R-HSA-977225 2.396749e-03 2.620 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.459841e-03 2.609 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.470128e-03 2.607 0 0
MTOR signalling R-HSA-165159 2.507028e-03 2.601 1 0
Programmed Cell Death R-HSA-5357801 2.534041e-03 2.596 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.576367e-03 2.589 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 2.576367e-03 2.589 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.619393e-03 2.582 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.656081e-03 2.576 0 0
ALK mutants bind TKIs R-HSA-9700645 2.887683e-03 2.539 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.783769e-03 2.555 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.783769e-03 2.555 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.887683e-03 2.539 0 0
DNA Replication R-HSA-69306 3.015046e-03 2.521 0 0
Base Excision Repair R-HSA-73884 2.837675e-03 2.547 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 3.142280e-03 2.503 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.243843e-03 2.489 0 0
Signaling by WNT R-HSA-195721 3.310869e-03 2.480 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.505412e-03 2.455 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 4.130395e-03 2.384 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 4.130395e-03 2.384 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 4.130395e-03 2.384 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 4.130395e-03 2.384 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 4.130395e-03 2.384 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 4.130395e-03 2.384 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 4.130395e-03 2.384 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 4.130395e-03 2.384 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 4.130395e-03 2.384 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 4.130395e-03 2.384 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 4.130395e-03 2.384 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.042345e-03 2.393 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 3.986150e-03 2.399 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 4.042345e-03 2.393 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 3.994786e-03 2.399 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.686744e-03 2.433 0 0
Smooth Muscle Contraction R-HSA-445355 3.986150e-03 2.399 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 4.042345e-03 2.393 0 0
Nephrin family interactions R-HSA-373753 4.167214e-03 2.380 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.181108e-03 2.379 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 4.181108e-03 2.379 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 4.402674e-03 2.356 0 0
DCC mediated attractive signaling R-HSA-418885 4.405504e-03 2.356 0 0
Protein methylation R-HSA-8876725 4.405504e-03 2.356 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 5.576938e-03 2.254 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 6.025033e-03 2.220 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 6.297695e-03 2.201 0 0
Separation of Sister Chromatids R-HSA-2467813 6.452064e-03 2.190 0 0
Nuclear Envelope Breakdown R-HSA-2980766 6.463509e-03 2.190 0 0
Ca-dependent events R-HSA-111996 7.312538e-03 2.136 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 7.365366e-03 2.133 0 0
Protein ubiquitination R-HSA-8852135 7.365366e-03 2.133 0 0
mTORC1-mediated signalling R-HSA-166208 7.548645e-03 2.122 1 1
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 7.612990e-03 2.118 0 0
CaM pathway R-HSA-111997 8.075067e-03 2.093 0 0
Calmodulin induced events R-HSA-111933 8.075067e-03 2.093 0 0
Kinesins R-HSA-983189 9.016624e-03 2.045 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 9.279723e-03 2.032 0 0
mRNA 3'-end processing R-HSA-72187 9.318561e-03 2.031 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.119912e-02 1.951 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.119912e-02 1.951 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.119912e-02 1.951 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.119912e-02 1.951 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.119912e-02 1.951 0 0
Ephrin signaling R-HSA-3928664 1.068493e-02 1.971 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.068493e-02 1.971 0 0
PLC beta mediated events R-HSA-112043 1.002268e-02 1.999 0 0
Membrane Trafficking R-HSA-199991 1.164475e-02 1.934 0 0
Formation of annular gap junctions R-HSA-196025 1.188220e-02 1.925 0 0
Semaphorin interactions R-HSA-373755 1.229373e-02 1.910 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.263430e-02 1.898 0 0
Deubiquitination R-HSA-5688426 1.340120e-02 1.873 0 0
Recycling pathway of L1 R-HSA-437239 1.347330e-02 1.871 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.351373e-02 1.869 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.507004e-02 1.822 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.512598e-02 1.820 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 1.548196e-02 1.810 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.583471e-02 1.800 0 0
Gap junction degradation R-HSA-190873 1.583471e-02 1.800 0 0
Regulation of CDH1 Function R-HSA-9764561 1.593369e-02 1.798 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.651601e-02 1.782 0 0
Regulation of TP53 Activity R-HSA-5633007 1.663913e-02 1.779 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.714247e-02 1.766 0 0
MAP2K and MAPK activation R-HSA-5674135 1.743381e-02 1.759 0 0
EPH-Ephrin signaling R-HSA-2682334 1.769266e-02 1.752 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.784587e-02 1.748 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.784587e-02 1.748 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.784587e-02 1.748 0 0
G-protein mediated events R-HSA-112040 1.799688e-02 1.745 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.843513e-02 1.734 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.861774e-02 1.730 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.001531e-02 1.699 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.136530e-02 1.670 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.159571e-02 1.666 0 0
Signaling by APC mutants R-HSA-4839744 2.598746e-02 1.585 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.598746e-02 1.585 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.598746e-02 1.585 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.598746e-02 1.585 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.336600e-02 1.631 0 0
Activation of the pre-replicative complex R-HSA-68962 2.589263e-02 1.587 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.556066e-02 1.592 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.542533e-02 1.595 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.393010e-02 1.621 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.334936e-02 1.632 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.242862e-02 1.649 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.432103e-02 1.614 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.624577e-02 1.581 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.624577e-02 1.581 0 0
DAG and IP3 signaling R-HSA-1489509 2.699496e-02 1.569 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.986957e-02 1.525 0 0
Signaling by Hippo R-HSA-2028269 3.179506e-02 1.498 0 0
Signaling by GSK3beta mutants R-HSA-5339716 3.224234e-02 1.492 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 3.224234e-02 1.492 0 0
Signaling by AXIN mutants R-HSA-4839735 3.224234e-02 1.492 0 0
Signaling by AMER1 mutants R-HSA-4839748 3.224234e-02 1.492 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 3.224234e-02 1.492 0 0
L1CAM interactions R-HSA-373760 3.237026e-02 1.490 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.243617e-02 1.489 0 0
IRE1alpha activates chaperones R-HSA-381070 3.271495e-02 1.485 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 3.319678e-02 1.479 0 0
Ub-specific processing proteases R-HSA-5689880 3.485467e-02 1.458 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.530074e-02 1.452 0 0
Developmental Biology R-HSA-1266738 3.588980e-02 1.445 0 0
Co-stimulation by CD28 R-HSA-389356 3.624612e-02 1.441 0 0
Chaperone Mediated Autophagy R-HSA-9613829 3.730885e-02 1.428 0 0
HDMs demethylate histones R-HSA-3214842 3.828506e-02 1.417 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.930401e-02 1.406 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 3.930401e-02 1.406 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 3.930401e-02 1.406 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 3.930401e-02 1.406 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 3.930401e-02 1.406 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 3.930401e-02 1.406 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 4.041597e-02 1.393 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.041597e-02 1.393 0 0
Striated Muscle Contraction R-HSA-390522 4.171278e-02 1.380 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 4.337358e-02 1.363 0 0
Rap1 signalling R-HSA-392517 4.337358e-02 1.363 0 0
S Phase R-HSA-69242 4.435631e-02 1.353 0 0
Unfolded Protein Response (UPR) R-HSA-381119 4.495053e-02 1.347 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 4.575461e-02 1.340 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 4.575461e-02 1.340 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 5.755784e-02 1.240 0 0
Type I hemidesmosome assembly R-HSA-446107 5.755784e-02 1.240 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 5.755784e-02 1.240 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 5.755784e-02 1.240 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 4.717749e-02 1.326 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.585979e-02 1.253 0 0
Co-inhibition by CTLA4 R-HSA-389513 4.999613e-02 1.301 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.904887e-02 1.309 0 0
Interaction between L1 and Ankyrins R-HSA-445095 4.904887e-02 1.309 0 0
HIV elongation arrest and recovery R-HSA-167287 5.506197e-02 1.259 0 0
Pausing and recovery of HIV elongation R-HSA-167290 5.506197e-02 1.259 0 0
EPHB-mediated forward signaling R-HSA-3928662 5.708214e-02 1.243 0 0
Frs2-mediated activation R-HSA-170968 4.717749e-02 1.326 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 5.043822e-02 1.297 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 4.717749e-02 1.326 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 5.628828e-02 1.250 0 0
Neurexins and neuroligins R-HSA-6794361 5.166133e-02 1.287 0 0
Regulation of PTEN gene transcription R-HSA-8943724 4.661350e-02 1.331 0 0
RMTs methylate histone arginines R-HSA-3214858 5.708214e-02 1.243 0 0
Netrin-1 signaling R-HSA-373752 5.708214e-02 1.243 0 0
PKR-mediated signaling R-HSA-9833482 5.021489e-02 1.299 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 5.869236e-02 1.231 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 6.001486e-02 1.222 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 6.031529e-02 1.220 0 0
Rab regulation of trafficking R-HSA-9007101 6.045389e-02 1.219 0 0
HCMV Early Events R-HSA-9609690 6.063968e-02 1.217 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 6.150073e-02 1.211 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 6.369682e-02 1.196 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 6.492408e-02 1.188 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 6.534054e-02 1.185 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 6.534054e-02 1.185 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 6.534054e-02 1.185 0 0
HIV Life Cycle R-HSA-162587 6.761507e-02 1.170 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 6.767616e-02 1.170 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 6.778409e-02 1.169 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 6.836634e-02 1.165 0 0
Gene expression (Transcription) R-HSA-74160 6.886005e-02 1.162 0 0
ISG15 antiviral mechanism R-HSA-1169408 6.892561e-02 1.162 0 0
Protein-protein interactions at synapses R-HSA-6794362 6.936431e-02 1.159 0 0
GP1b-IX-V activation signalling R-HSA-430116 7.064413e-02 1.151 0 0
Unwinding of DNA R-HSA-176974 7.064413e-02 1.151 0 0
Signaling by EGFR R-HSA-177929 7.084437e-02 1.150 0 0
NRAGE signals death through JNK R-HSA-193648 7.084437e-02 1.150 0 0
RNA Polymerase II Transcription R-HSA-73857 7.154517e-02 1.145 0 0
AURKA Activation by TPX2 R-HSA-8854518 7.264794e-02 1.139 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 7.550079e-02 1.122 0 0
Prolonged ERK activation events R-HSA-169893 7.560271e-02 1.121 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 7.583970e-02 1.120 0 0
PDGFR mutants bind TKIs R-HSA-9674428 7.583970e-02 1.120 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 7.583970e-02 1.120 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 7.583970e-02 1.120 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 7.583970e-02 1.120 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 7.583970e-02 1.120 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 7.583970e-02 1.120 0 0
Response of endothelial cells to shear stress R-HSA-9860931 7.668731e-02 1.115 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 8.210969e-02 1.086 0 0
Generation of second messenger molecules R-HSA-202433 8.210969e-02 1.086 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 8.216052e-02 1.085 0 0
Post NMDA receptor activation events R-HSA-438064 8.286114e-02 1.082 0 0
G0 and Early G1 R-HSA-1538133 8.337334e-02 1.079 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 8.493446e-02 1.071 0 0
IRS activation R-HSA-74713 1.063546e-01 0.973 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.063546e-01 0.973 0 0
PECAM1 interactions R-HSA-210990 1.003405e-01 0.999 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.108222e-01 0.955 0 0
PKA activation R-HSA-163615 1.108222e-01 0.955 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.183558e-01 0.927 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.138144e-01 0.944 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.138144e-01 0.944 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.126931e-01 0.948 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 9.885665e-02 1.005 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.182882e-01 0.927 0 0
Signaling by ERBB2 R-HSA-1227986 9.393400e-02 1.027 0 0
Cellular response to starvation R-HSA-9711097 1.096403e-01 0.960 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.063546e-01 0.973 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.003405e-01 0.999 0 0
Myogenesis R-HSA-525793 1.118190e-01 0.951 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 9.375894e-02 1.028 0 0
Pyrophosphate hydrolysis R-HSA-71737 1.063546e-01 0.973 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.170482e-01 0.932 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.048355e-01 0.979 0 0
G-protein beta:gamma signalling R-HSA-397795 9.150771e-02 1.039 0 0
Signaling by MET R-HSA-6806834 9.375894e-02 1.028 0 0
Platelet sensitization by LDL R-HSA-432142 1.108222e-01 0.955 0 0
Signaling by FGFR1 in disease R-HSA-5655302 9.672265e-02 1.014 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.013879e-01 0.994 0 0
FGFR1 mutant receptor activation R-HSA-1839124 9.150771e-02 1.039 0 0
Signaling by Nuclear Receptors R-HSA-9006931 9.285819e-02 1.032 0 0
MAPK family signaling cascades R-HSA-5683057 1.112364e-01 0.954 0 0
HCMV Late Events R-HSA-9610379 1.054794e-01 0.977 0 0
Negative regulation of MAPK pathway R-HSA-5675221 9.672265e-02 1.014 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 9.150771e-02 1.039 0 0
Signaling by FGFR in disease R-HSA-1226099 1.192641e-01 0.923 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 9.150771e-02 1.039 0 0
Co-inhibition by PD-1 R-HSA-389948 1.059955e-01 0.975 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.108222e-01 0.955 0 0
Interleukin-7 signaling R-HSA-1266695 1.013879e-01 0.994 0 0
Translation initiation complex formation R-HSA-72649 1.217091e-01 0.915 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.227443e-01 0.911 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.227443e-01 0.911 0 0
Regulation of signaling by CBL R-HSA-912631 1.239312e-01 0.907 0 0
Centrosome maturation R-HSA-380287 1.260427e-01 0.899 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.274401e-01 0.895 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.301446e-01 0.886 0 0
MHC class II antigen presentation R-HSA-2132295 1.311971e-01 0.882 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.321595e-01 0.879 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 1.321595e-01 0.879 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.321595e-01 0.879 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 1.321595e-01 0.879 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.321595e-01 0.879 0 0
Interleukin-12 signaling R-HSA-9020591 1.330262e-01 0.876 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.341174e-01 0.873 0 0
Disorders of Nervous System Development R-HSA-9697154 1.341174e-01 0.873 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.341174e-01 0.873 0 0
Pervasive developmental disorders R-HSA-9005895 1.341174e-01 0.873 0 0
Telomere Extension By Telomerase R-HSA-171319 1.341439e-01 0.872 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 1.341439e-01 0.872 0 0
Formation of the Early Elongation Complex R-HSA-113418 1.341439e-01 0.872 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.364742e-01 0.865 0 0
Signal transduction by L1 R-HSA-445144 1.376610e-01 0.861 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.376610e-01 0.861 0 0
Negative regulation of MET activity R-HSA-6807004 1.376610e-01 0.861 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.379664e-01 0.860 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.379664e-01 0.860 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.381947e-01 0.860 0 0
Death Receptor Signaling R-HSA-73887 1.420949e-01 0.847 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.459319e-01 0.836 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.459319e-01 0.836 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.459319e-01 0.836 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.459319e-01 0.836 0 0
Activation and oligomerization of BAK protein R-HSA-111452 1.459319e-01 0.836 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 1.459319e-01 0.836 0 0
Regulation of gene expression in beta cells R-HSA-210745 1.459961e-01 0.836 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.468468e-01 0.833 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.483905e-01 0.829 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 1.486598e-01 0.828 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.516452e-01 0.819 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.516452e-01 0.819 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.519694e-01 0.818 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.519694e-01 0.818 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.527199e-01 0.816 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.537796e-01 0.813 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.537796e-01 0.813 0 0
IKBKB deficiency causes SCID R-HSA-5602636 2.107119e-01 0.676 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.107119e-01 0.676 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.107119e-01 0.676 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 2.107119e-01 0.676 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 1.591922e-01 0.798 0 0
Autointegration results in viral DNA circles R-HSA-177539 1.591922e-01 0.798 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 1.591922e-01 0.798 0 0
SOS-mediated signalling R-HSA-112412 1.871185e-01 0.728 0 0
MET receptor recycling R-HSA-8875656 2.156477e-01 0.666 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.107365e-01 0.676 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.107365e-01 0.676 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.668120e-01 0.778 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.668120e-01 0.778 0 0
FGFR2 alternative splicing R-HSA-6803529 1.821430e-01 0.740 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.582774e-01 0.801 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.140827e-01 0.669 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.594695e-01 0.797 0 0
Long-term potentiation R-HSA-9620244 2.305970e-01 0.637 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.974415e-01 0.705 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.706081e-01 0.768 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.111798e-01 0.675 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 2.252132e-01 0.647 0 0
snRNP Assembly R-HSA-191859 1.642647e-01 0.784 0 0
Metabolism of non-coding RNA R-HSA-194441 1.642647e-01 0.784 0 0
Orc1 removal from chromatin R-HSA-68949 1.994510e-01 0.700 0 0
Amino acids regulate mTORC1 R-HSA-9639288 2.104052e-01 0.677 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.597568e-01 0.797 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.207891e-01 0.656 0 0
HIV Transcription Elongation R-HSA-167169 1.706081e-01 0.768 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.879276e-01 0.726 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 1.706081e-01 0.768 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 1.582774e-01 0.801 0 0
Integrin signaling R-HSA-354192 1.974415e-01 0.705 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.552528e-01 0.809 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.840266e-01 0.735 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.594695e-01 0.797 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.594695e-01 0.797 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.031269e-01 0.692 0 0
Nuclear import of Rev protein R-HSA-180746 2.252132e-01 0.647 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.027159e-01 0.693 0 0
HCMV Infection R-HSA-9609646 1.772505e-01 0.751 0 0
Nuclear RNA decay R-HSA-9930044 1.974415e-01 0.705 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.058283e-01 0.686 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.878383e-01 0.726 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.706081e-01 0.768 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 2.156477e-01 0.666 0 0
rRNA processing R-HSA-72312 2.025749e-01 0.693 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.297774e-01 0.639 0 0
Opioid Signalling R-HSA-111885 2.031269e-01 0.692 0 0
eNOS activation R-HSA-203615 2.252132e-01 0.647 0 0
HIV Infection R-HSA-162906 1.774762e-01 0.751 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.132603e-01 0.671 0 0
G1/S Transition R-HSA-69206 2.217589e-01 0.654 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.107119e-01 0.676 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 2.156477e-01 0.666 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.706081e-01 0.768 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.222118e-01 0.653 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 2.312064e-01 0.636 0 0
Vesicle-mediated transport R-HSA-5653656 2.163181e-01 0.665 0 0
Nef and signal transduction R-HSA-164944 1.591922e-01 0.798 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.906970e-01 0.720 0 0
DNA strand elongation R-HSA-69190 1.840266e-01 0.735 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.140827e-01 0.669 0 0
TBC/RABGAPs R-HSA-8854214 2.181099e-01 0.661 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 1.591922e-01 0.798 0 0
Disorders of Developmental Biology R-HSA-9675151 2.312064e-01 0.636 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.058283e-01 0.686 0 0
Muscle contraction R-HSA-397014 2.202883e-01 0.657 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.906970e-01 0.720 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.821430e-01 0.740 0 0
Syndecan interactions R-HSA-3000170 1.979157e-01 0.704 0 0
Activation of BH3-only proteins R-HSA-114452 1.582774e-01 0.801 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 1.871185e-01 0.728 0 0
Sodium/Proton exchangers R-HSA-425986 2.156477e-01 0.666 0 0
Generic Transcription Pathway R-HSA-212436 1.853622e-01 0.732 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.659655e-01 0.780 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.140827e-01 0.669 0 0
Neurodegenerative Diseases R-HSA-8863678 2.140827e-01 0.669 0 0
Influenza Infection R-HSA-168255 2.253972e-01 0.647 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.668120e-01 0.778 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.312064e-01 0.636 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 2.156477e-01 0.666 0 0
Interleukin-12 family signaling R-HSA-447115 2.313080e-01 0.636 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 2.705820e-01 0.568 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 2.705820e-01 0.568 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 2.705820e-01 0.568 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 2.705820e-01 0.568 0 0
MET activates PTPN11 R-HSA-8865999 3.259141e-01 0.487 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 2.445279e-01 0.612 0 0
WNT mediated activation of DVL R-HSA-201688 2.445279e-01 0.612 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 3.770518e-01 0.424 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 3.770518e-01 0.424 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 3.770518e-01 0.424 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 3.770518e-01 0.424 0 0
Signaling by MAP2K mutants R-HSA-9652169 3.770518e-01 0.424 0 0
MAPK3 (ERK1) activation R-HSA-110056 2.735420e-01 0.563 0 0
G2 Phase R-HSA-68911 4.243129e-01 0.372 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 4.243129e-01 0.372 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.520165e-01 0.599 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.520165e-01 0.599 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.520165e-01 0.599 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 3.312542e-01 0.480 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 3.312542e-01 0.480 0 0
GAB1 signalosome R-HSA-180292 2.730810e-01 0.564 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 3.596590e-01 0.444 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 3.596590e-01 0.444 0 0
Scavenging by Class F Receptors R-HSA-3000484 3.596590e-01 0.444 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 4.679911e-01 0.330 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 4.679911e-01 0.330 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 4.679911e-01 0.330 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 3.156533e-01 0.501 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 3.876053e-01 0.412 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 3.370140e-01 0.472 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 3.370140e-01 0.472 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.991977e-01 0.524 0 0
mRNA Capping R-HSA-72086 2.991977e-01 0.524 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.167601e-01 0.499 0 0
Retrograde neurotrophin signalling R-HSA-177504 4.149992e-01 0.382 0 0
EGFR downregulation R-HSA-182971 3.344025e-01 0.476 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 3.344025e-01 0.476 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 3.344025e-01 0.476 0 0
Erythropoietin activates RAS R-HSA-9027284 4.417638e-01 0.355 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 4.417638e-01 0.355 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 4.006198e-01 0.397 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 4.006198e-01 0.397 0 0
Peptide chain elongation R-HSA-156902 2.405420e-01 0.619 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.405420e-01 0.619 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.697711e-01 0.432 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.993513e-01 0.524 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 3.874235e-01 0.412 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.214781e-01 0.375 0 0
Deadenylation of mRNA R-HSA-429947 4.214781e-01 0.375 0 0
Phosphorylation of the APC/C R-HSA-176412 4.678369e-01 0.330 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 2.787133e-01 0.555 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 4.623983e-01 0.335 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.054136e-01 0.392 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 3.915961e-01 0.407 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.892944e-01 0.410 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.892944e-01 0.410 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 4.467497e-01 0.350 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 4.633953e-01 0.334 0 0
Transcription of the HIV genome R-HSA-167172 3.927171e-01 0.406 0 0
Signaling by EGFR in Cancer R-HSA-1643713 4.623983e-01 0.335 0 0
Downstream signal transduction R-HSA-186763 3.344025e-01 0.476 0 0
MET promotes cell motility R-HSA-8875878 2.837233e-01 0.547 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.697711e-01 0.432 0 0
Ribosome-associated quality control R-HSA-9948299 4.498079e-01 0.347 0 0
Extension of Telomeres R-HSA-180786 2.801976e-01 0.553 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.805705e-01 0.420 0 0
DNA Damage Bypass R-HSA-73893 2.961370e-01 0.529 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 3.697711e-01 0.432 0 0
Regulation of CDH11 function R-HSA-9762292 2.735420e-01 0.563 0 0
PI3K/AKT activation R-HSA-198203 2.735420e-01 0.563 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 4.678369e-01 0.330 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.107523e-01 0.508 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 4.338640e-01 0.363 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.709132e-01 0.431 0 0
Regulation of gap junction activity R-HSA-191650 3.770518e-01 0.424 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 4.243129e-01 0.372 0 0
VLDLR internalisation and degradation R-HSA-8866427 3.596590e-01 0.444 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 2.540505e-01 0.595 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 4.417638e-01 0.355 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 4.214781e-01 0.375 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.499909e-01 0.456 0 0
G2/M Transition R-HSA-69275 3.558973e-01 0.449 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.063338e-01 0.391 0 0
Integration of provirus R-HSA-162592 3.312542e-01 0.480 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.583348e-01 0.446 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.937432e-01 0.532 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 4.243129e-01 0.372 0 0
Killing mechanisms R-HSA-9664420 4.678369e-01 0.330 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 4.678369e-01 0.330 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.730810e-01 0.564 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 4.417638e-01 0.355 0 0
Acyl chain remodelling of PS R-HSA-1482801 4.420845e-01 0.354 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.623983e-01 0.335 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 4.679911e-01 0.330 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 4.679911e-01 0.330 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.149992e-01 0.382 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.598525e-01 0.585 0 0
Degradation of CDH1 R-HSA-9766229 4.671966e-01 0.331 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 2.694334e-01 0.570 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.547297e-01 0.594 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.293022e-01 0.482 0 0
tRNA processing in the nucleus R-HSA-6784531 3.170562e-01 0.499 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 3.973462e-01 0.401 0 0
Signaling by WNT in cancer R-HSA-4791275 3.520855e-01 0.453 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.644798e-01 0.578 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 3.596590e-01 0.444 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 4.433854e-01 0.353 0 0
Synthesis of DNA R-HSA-69239 4.633953e-01 0.334 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.627858e-01 0.580 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 2.705820e-01 0.568 0 0
MET interacts with TNS proteins R-HSA-8875513 3.259141e-01 0.487 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 3.770518e-01 0.424 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 3.770518e-01 0.424 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 2.735420e-01 0.563 0 0
Bicarbonate transporters R-HSA-425381 3.025037e-01 0.519 0 0
Reelin signalling pathway R-HSA-8866376 4.243129e-01 0.372 0 0
PKA activation in glucagon signalling R-HSA-164378 2.730810e-01 0.564 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 2.943186e-01 0.531 0 0
Cam-PDE 1 activation R-HSA-111957 4.679911e-01 0.330 0 0
Phosphorylation of Emi1 R-HSA-176417 4.679911e-01 0.330 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 3.876053e-01 0.412 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.991977e-01 0.524 0 0
DARPP-32 events R-HSA-180024 2.991977e-01 0.524 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.837233e-01 0.547 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 4.417638e-01 0.355 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 4.417638e-01 0.355 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 4.678369e-01 0.330 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 4.398530e-01 0.357 0 0
Viral Messenger RNA Synthesis R-HSA-168325 4.612511e-01 0.336 0 0
Autophagy R-HSA-9612973 3.028520e-01 0.519 0 0
TCR signaling R-HSA-202403 3.695800e-01 0.432 0 0
Aggrephagy R-HSA-9646399 3.140036e-01 0.503 0 0
p75NTR signals via NF-kB R-HSA-193639 4.417638e-01 0.355 0 0
Spry regulation of FGF signaling R-HSA-1295596 4.417638e-01 0.355 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.697711e-01 0.432 0 0
Platelet degranulation R-HSA-114608 2.367080e-01 0.626 0 0
p75NTR recruits signalling complexes R-HSA-209543 3.596590e-01 0.444 0 0
DNA Damage Reversal R-HSA-73942 4.417638e-01 0.355 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 2.445279e-01 0.612 0 0
Signal attenuation R-HSA-74749 2.735420e-01 0.563 0 0
NRIF signals cell death from the nucleus R-HSA-205043 4.149992e-01 0.382 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 3.916887e-01 0.407 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.943186e-01 0.531 0 0
FLT3 signaling in disease R-HSA-9682385 4.398530e-01 0.357 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 2.445279e-01 0.612 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 2.445279e-01 0.612 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 3.312542e-01 0.480 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 4.679911e-01 0.330 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.644798e-01 0.578 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 4.149992e-01 0.382 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.874235e-01 0.412 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 4.678369e-01 0.330 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 4.216783e-01 0.375 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 3.666946e-01 0.436 0 0
Macroautophagy R-HSA-1632852 3.676356e-01 0.435 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 4.149992e-01 0.382 0 0
Regulation of KIT signaling R-HSA-1433559 4.149992e-01 0.382 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 4.678369e-01 0.330 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 2.918954e-01 0.535 0 0
Signalling to ERKs R-HSA-187687 4.224953e-01 0.374 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.426429e-01 0.354 0 0
Signaling by PTK6 R-HSA-8848021 3.295348e-01 0.482 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.295348e-01 0.482 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 3.259141e-01 0.487 0 0
ARMS-mediated activation R-HSA-170984 2.445279e-01 0.612 0 0
Josephin domain DUBs R-HSA-5689877 2.735420e-01 0.563 0 0
2-LTR circle formation R-HSA-164843 2.735420e-01 0.563 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 3.312542e-01 0.480 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 4.679911e-01 0.330 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 3.370140e-01 0.472 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 2.563122e-01 0.591 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.988015e-01 0.525 0 0
Negative regulation of FLT3 R-HSA-9706369 4.678369e-01 0.330 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 4.678369e-01 0.330 0 0
Metalloprotease DUBs R-HSA-5689901 4.623983e-01 0.335 0 0
FLT3 Signaling R-HSA-9607240 3.293022e-01 0.482 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 3.152042e-01 0.501 0 0
Interleukin-1 signaling R-HSA-9020702 3.905407e-01 0.408 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.395130e-01 0.621 0 0
Glycolysis R-HSA-70171 3.801397e-01 0.420 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 3.874235e-01 0.412 0 0
Gap junction trafficking and regulation R-HSA-157858 4.671966e-01 0.331 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.687968e-01 0.571 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.697711e-01 0.432 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.185445e-01 0.497 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.653439e-01 0.576 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 4.540318e-01 0.343 0 0
Interferon Signaling R-HSA-913531 3.102294e-01 0.508 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.923910e-01 0.406 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 2.705820e-01 0.568 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.445279e-01 0.612 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 3.770518e-01 0.424 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 2.735420e-01 0.563 0 0
E2F mediated regulation of DNA replication R-HSA-113510 2.943186e-01 0.531 0 0
RET signaling R-HSA-8853659 4.398530e-01 0.357 0 0
NGF-stimulated transcription R-HSA-9031628 4.521294e-01 0.345 0 0
Viral Infection Pathways R-HSA-9824446 2.904984e-01 0.537 0 0
Sensory processing of sound R-HSA-9659379 2.526381e-01 0.598 0 0
Maturation of nucleoprotein R-HSA-9683610 3.876053e-01 0.412 0 0
Maturation of nucleoprotein R-HSA-9694631 2.943186e-01 0.531 0 0
G1/S-Specific Transcription R-HSA-69205 2.540505e-01 0.595 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.562540e-01 0.591 0 0
Interleukin-2 signaling R-HSA-9020558 3.025037e-01 0.519 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.644798e-01 0.578 0 0
Signaling by NTRKs R-HSA-166520 4.371171e-01 0.359 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 2.705820e-01 0.568 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 2.445279e-01 0.612 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 3.025037e-01 0.519 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 4.243129e-01 0.372 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 4.679911e-01 0.330 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 3.876053e-01 0.412 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 3.583348e-01 0.446 0 0
Signal regulatory protein family interactions R-HSA-391160 4.149992e-01 0.382 0 0
G alpha (12/13) signalling events R-HSA-416482 3.688411e-01 0.433 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.433714e-01 0.614 0 0
TNF signaling R-HSA-75893 3.923910e-01 0.406 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 4.679911e-01 0.330 0 0
CD28 dependent Vav1 pathway R-HSA-389359 3.876053e-01 0.412 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.697711e-01 0.432 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 4.678369e-01 0.330 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 4.307603e-01 0.366 0 0
OAS antiviral response R-HSA-8983711 3.596590e-01 0.444 0 0
Signaling by NOTCH R-HSA-157118 2.460835e-01 0.609 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.761612e-01 0.559 0 0
Signaling by Leptin R-HSA-2586552 2.735420e-01 0.563 0 0
Interleukin-37 signaling R-HSA-9008059 3.167601e-01 0.499 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 4.243129e-01 0.372 0 0
Interleukin-1 family signaling R-HSA-446652 4.718914e-01 0.326 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 4.744602e-01 0.324 0 0
Heme signaling R-HSA-9707616 4.748217e-01 0.323 0 0
Adaptive Immune System R-HSA-1280218 4.778212e-01 0.321 0 0
Regulation of RAS by GAPs R-HSA-5658442 4.821340e-01 0.317 0 0
Cilium Assembly R-HSA-5617833 4.821818e-01 0.317 0 0
Cristae formation R-HSA-8949613 4.823832e-01 0.317 0 0
Insulin processing R-HSA-264876 4.823832e-01 0.317 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 4.882922e-01 0.311 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 4.931695e-01 0.307 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 4.931695e-01 0.307 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 4.931695e-01 0.307 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 4.931695e-01 0.307 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 4.931695e-01 0.307 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 4.931695e-01 0.307 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.942602e-01 0.306 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.942602e-01 0.306 0 0
Selective autophagy R-HSA-9663891 4.975173e-01 0.303 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 4.977069e-01 0.303 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 5.020072e-01 0.299 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 5.020072e-01 0.299 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 5.020072e-01 0.299 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 5.020072e-01 0.299 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 5.074727e-01 0.295 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 5.074727e-01 0.295 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 5.074727e-01 0.295 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 5.074727e-01 0.295 0 0
Diseases of Immune System R-HSA-5260271 5.074727e-01 0.295 0 0
Signaling by LTK in cancer R-HSA-9842640 5.083578e-01 0.294 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 5.083578e-01 0.294 0 0
STAT5 Activation R-HSA-9645135 5.083578e-01 0.294 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.083578e-01 0.294 0 0
G2/M DNA replication checkpoint R-HSA-69478 5.083578e-01 0.294 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 5.115529e-01 0.291 0 0
Hedgehog 'off' state R-HSA-5610787 5.119104e-01 0.291 0 0
Signaling by Interleukins R-HSA-449147 5.168235e-01 0.287 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 5.177238e-01 0.286 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 5.177238e-01 0.286 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 5.177238e-01 0.286 0 0
Specification of primordial germ cells R-HSA-9827857 5.177238e-01 0.286 0 0
Uptake and function of anthrax toxins R-HSA-5210891 5.177238e-01 0.286 0 0
Nuclear Receptor transcription pathway R-HSA-383280 5.177391e-01 0.286 0 0
Signaling by Erythropoietin R-HSA-9006335 5.212423e-01 0.283 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.238114e-01 0.281 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 5.238114e-01 0.281 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 5.260041e-01 0.279 0 0
Host Interactions of HIV factors R-HSA-162909 5.266137e-01 0.279 0 0
Cytokine Signaling in Immune system R-HSA-1280215 5.318284e-01 0.274 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 5.400645e-01 0.268 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 5.400645e-01 0.268 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 5.400645e-01 0.268 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 5.402646e-01 0.267 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 5.414722e-01 0.266 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 5.414722e-01 0.266 0 0
Presynaptic function of Kainate receptors R-HSA-500657 5.414722e-01 0.266 0 0
Mismatch Repair R-HSA-5358508 5.414722e-01 0.266 0 0
Nephron development R-HSA-9831926 5.414722e-01 0.266 0 0
Signaling by FGFR2 R-HSA-5654738 5.417466e-01 0.266 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 5.456638e-01 0.263 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 5.456638e-01 0.263 0 0
IFNG signaling activates MAPKs R-HSA-9732724 5.456638e-01 0.263 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 5.456638e-01 0.263 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 5.456638e-01 0.263 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 5.456638e-01 0.263 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 5.456638e-01 0.263 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 5.456638e-01 0.263 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 5.456638e-01 0.263 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 5.456638e-01 0.263 0 0
VLDL clearance R-HSA-8964046 5.456638e-01 0.263 0 0
CHL1 interactions R-HSA-447041 5.456638e-01 0.263 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 5.544411e-01 0.256 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 5.556782e-01 0.255 0 0
Trafficking of AMPA receptors R-HSA-399719 5.584535e-01 0.253 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 5.643956e-01 0.248 0 0
Translesion Synthesis by POLH R-HSA-110320 5.643956e-01 0.248 0 0
The NLRP3 inflammasome R-HSA-844456 5.643956e-01 0.248 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 5.643956e-01 0.248 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.681651e-01 0.246 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 5.681651e-01 0.246 0 0
Signaling by SCF-KIT R-HSA-1433557 5.711762e-01 0.243 0 0
PTEN Regulation R-HSA-6807070 5.733218e-01 0.242 0 0
Nucleotide Excision Repair R-HSA-5696398 5.744918e-01 0.241 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 5.763920e-01 0.239 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.787982e-01 0.237 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 5.787982e-01 0.237 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 5.801411e-01 0.236 0 0
phospho-PLA2 pathway R-HSA-111995 5.801411e-01 0.236 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 5.801411e-01 0.236 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 5.801411e-01 0.236 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 5.801411e-01 0.236 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 5.801411e-01 0.236 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 5.801411e-01 0.236 0 0
TGFBR3 PTM regulation R-HSA-9839383 5.801411e-01 0.236 0 0
Glucose metabolism R-HSA-70326 5.834682e-01 0.234 0 0
G1 Phase R-HSA-69236 5.863666e-01 0.232 0 0
Cyclin D associated events in G1 R-HSA-69231 5.863666e-01 0.232 0 0
Gap junction trafficking R-HSA-190828 5.863666e-01 0.232 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 5.864823e-01 0.232 0 0
Protein hydroxylation R-HSA-9629569 5.864823e-01 0.232 0 0
Formation of definitive endoderm R-HSA-9823730 5.864823e-01 0.232 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 5.881810e-01 0.230 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 5.910671e-01 0.228 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 5.938661e-01 0.226 0 0
Dual incision in TC-NER R-HSA-6782135 5.951679e-01 0.225 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 5.966510e-01 0.224 0 0
Eukaryotic Translation Termination R-HSA-72764 5.966510e-01 0.224 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 6.012388e-01 0.221 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 6.031463e-01 0.220 0 0
SARS-CoV Infections R-HSA-9679506 6.062796e-01 0.217 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 6.070677e-01 0.217 0 0
SARS-CoV-2 Infection R-HSA-9694516 6.075491e-01 0.216 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 6.077275e-01 0.216 0 0
Lagging Strand Synthesis R-HSA-69186 6.077275e-01 0.216 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 6.077275e-01 0.216 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 6.079203e-01 0.216 0 0
Regulation of beta-cell development R-HSA-186712 6.083099e-01 0.216 0 0
Adipogenesis R-HSA-9843745 6.095792e-01 0.215 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 6.108649e-01 0.214 0 0
Miscellaneous transport and binding events R-HSA-5223345 6.108649e-01 0.214 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 6.108649e-01 0.214 0 0
Lipophagy R-HSA-9613354 6.120040e-01 0.213 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 6.120040e-01 0.213 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 6.120040e-01 0.213 0 0
Calcineurin activates NFAT R-HSA-2025928 6.120040e-01 0.213 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 6.120040e-01 0.213 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 6.120040e-01 0.213 0 0
Cellular response to mitochondrial stress R-HSA-9840373 6.120040e-01 0.213 0 0
Regulation of signaling by NODAL R-HSA-1433617 6.120040e-01 0.213 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 6.120040e-01 0.213 0 0
Regulated proteolysis of p75NTR R-HSA-193692 6.120040e-01 0.213 0 0
Interleukin-1 processing R-HSA-448706 6.120040e-01 0.213 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 6.120040e-01 0.213 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 6.120040e-01 0.213 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 6.157834e-01 0.211 0 0
Regulation of TNFR1 signaling R-HSA-5357905 6.157834e-01 0.211 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 6.173450e-01 0.209 0 0
Signaling by NOTCH4 R-HSA-9013694 6.267099e-01 0.203 0 0
Platelet activation, signaling and aggregation R-HSA-76002 6.268939e-01 0.203 0 0
Dual Incision in GG-NER R-HSA-5696400 6.273800e-01 0.202 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 6.273800e-01 0.202 0 0
NOD1/2 Signaling Pathway R-HSA-168638 6.273800e-01 0.202 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 6.274786e-01 0.202 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 6.274786e-01 0.202 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 6.274786e-01 0.202 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.281316e-01 0.202 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 6.281316e-01 0.202 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 6.281316e-01 0.202 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 6.338386e-01 0.198 0 0
MAP kinase activation R-HSA-450294 6.338386e-01 0.198 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 6.381832e-01 0.195 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 6.414506e-01 0.193 0 0
Folding of actin by CCT/TriC R-HSA-390450 6.414506e-01 0.193 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 6.414506e-01 0.193 0 0
Binding and entry of HIV virion R-HSA-173107 6.414506e-01 0.193 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 6.414506e-01 0.193 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 6.414506e-01 0.193 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 6.414506e-01 0.193 0 0
Pexophagy R-HSA-9664873 6.414506e-01 0.193 0 0
CASP4 inflammasome assembly R-HSA-9948001 6.414506e-01 0.193 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 6.414506e-01 0.193 0 0
Inositol phosphate metabolism R-HSA-1483249 6.426269e-01 0.192 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 6.434055e-01 0.192 0 0
Oncogene Induced Senescence R-HSA-2559585 6.434055e-01 0.192 0 0
Metal ion SLC transporters R-HSA-425410 6.438604e-01 0.191 0 0
Signaling by PDGF R-HSA-186797 6.462133e-01 0.190 0 0
Mitochondrial protein import R-HSA-1268020 6.462133e-01 0.190 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 6.462133e-01 0.190 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 6.462133e-01 0.190 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 6.476999e-01 0.189 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 6.476999e-01 0.189 0 0
LDL clearance R-HSA-8964038 6.476999e-01 0.189 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 6.476999e-01 0.189 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 6.476999e-01 0.189 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 6.476999e-01 0.189 0 0
Selenocysteine synthesis R-HSA-2408557 6.569789e-01 0.182 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 6.571871e-01 0.182 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 6.573814e-01 0.182 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 6.573814e-01 0.182 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 6.589377e-01 0.181 0 0
RNA Polymerase III Transcription R-HSA-74158 6.589377e-01 0.181 0 0
Glycosphingolipid transport R-HSA-9845576 6.589377e-01 0.181 0 0
RUNX2 regulates bone development R-HSA-8941326 6.589377e-01 0.181 0 0
FGFR2 mutant receptor activation R-HSA-1839126 6.589377e-01 0.181 0 0
Organelle biogenesis and maintenance R-HSA-1852241 6.651762e-01 0.177 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 6.664417e-01 0.176 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 6.664417e-01 0.176 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 6.664417e-01 0.176 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 6.664417e-01 0.176 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 6.664417e-01 0.176 0 0
Growth hormone receptor signaling R-HSA-982772 6.664417e-01 0.176 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 6.686640e-01 0.175 0 0
LGI-ADAM interactions R-HSA-5682910 6.686640e-01 0.175 0 0
Ionotropic activity of kainate receptors R-HSA-451306 6.686640e-01 0.175 0 0
vRNP Assembly R-HSA-192905 6.686640e-01 0.175 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 6.686640e-01 0.175 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 6.686640e-01 0.175 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 6.686640e-01 0.175 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 6.686640e-01 0.175 0 0
Suppression of apoptosis R-HSA-9635465 6.686640e-01 0.175 0 0
Transport of RCbl within the body R-HSA-9758890 6.686640e-01 0.175 0 0
IGF1R signaling cascade R-HSA-2428924 6.701599e-01 0.174 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 6.701599e-01 0.174 0 0
Ion transport by P-type ATPases R-HSA-936837 6.701599e-01 0.174 0 0
PI3K Cascade R-HSA-109704 6.705520e-01 0.174 0 0
Signaling by FGFR2 in disease R-HSA-5655253 6.705520e-01 0.174 0 0
Cellular response to chemical stress R-HSA-9711123 6.706411e-01 0.174 0 0
Potential therapeutics for SARS R-HSA-9679191 6.728295e-01 0.172 0 0
Degradation of DVL R-HSA-4641258 6.739752e-01 0.171 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 6.739752e-01 0.171 0 0
Viral mRNA Translation R-HSA-192823 6.758631e-01 0.170 0 0
Signaling by Hedgehog R-HSA-5358351 6.769367e-01 0.169 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 6.787002e-01 0.168 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 6.817249e-01 0.166 0 0
Cellular response to hypoxia R-HSA-1234174 6.817249e-01 0.166 0 0
The phototransduction cascade R-HSA-2514856 6.833694e-01 0.165 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 6.843697e-01 0.165 0 0
Complex III assembly R-HSA-9865881 6.843697e-01 0.165 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 6.850625e-01 0.164 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 6.885183e-01 0.162 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 6.938134e-01 0.159 0 0
NF-kB is activated and signals survival R-HSA-209560 6.938134e-01 0.159 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 6.938134e-01 0.159 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 6.938134e-01 0.159 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 6.938134e-01 0.159 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 6.938134e-01 0.159 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 6.938134e-01 0.159 0 0
Sodium/Calcium exchangers R-HSA-425561 6.938134e-01 0.159 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 6.938134e-01 0.159 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 6.938134e-01 0.159 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 6.958323e-01 0.157 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 7.003539e-01 0.155 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 7.014995e-01 0.154 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.014995e-01 0.154 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 7.014995e-01 0.154 0 0
TGFBR3 expression R-HSA-9839394 7.014995e-01 0.154 0 0
Tight junction interactions R-HSA-420029 7.014995e-01 0.154 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 7.014995e-01 0.154 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 7.014995e-01 0.154 0 0
Stabilization of p53 R-HSA-69541 7.025688e-01 0.153 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 7.025688e-01 0.153 0 0
Plasma lipoprotein clearance R-HSA-8964043 7.025688e-01 0.153 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.025688e-01 0.153 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 7.040266e-01 0.152 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 7.115201e-01 0.148 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 7.161304e-01 0.145 0 0
Glycogen metabolism R-HSA-8982491 7.161304e-01 0.145 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 7.161304e-01 0.145 0 0
Interleukin-2 family signaling R-HSA-451927 7.161304e-01 0.145 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 7.170554e-01 0.144 0 0
Polymerase switching R-HSA-69091 7.170554e-01 0.144 0 0
Leading Strand Synthesis R-HSA-69109 7.170554e-01 0.144 0 0
Repression of WNT target genes R-HSA-4641265 7.170554e-01 0.144 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 7.170554e-01 0.144 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 7.170554e-01 0.144 0 0
Signaling by LTK R-HSA-9842663 7.170554e-01 0.144 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 7.170554e-01 0.144 0 0
IRAK1 recruits IKK complex R-HSA-937039 7.170554e-01 0.144 0 0
MET activates RAS signaling R-HSA-8851805 7.170554e-01 0.144 0 0
Interleukin-15 signaling R-HSA-8983432 7.170554e-01 0.144 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 7.178489e-01 0.144 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.178489e-01 0.144 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.178489e-01 0.144 0 0
Developmental Cell Lineages R-HSA-9734767 7.190121e-01 0.143 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 7.205555e-01 0.142 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 7.205555e-01 0.142 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.205833e-01 0.142 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.285582e-01 0.138 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 7.292078e-01 0.137 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.334377e-01 0.135 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 7.334377e-01 0.135 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.334377e-01 0.135 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 7.334377e-01 0.135 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 7.334377e-01 0.135 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 7.334377e-01 0.135 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 7.353932e-01 0.133 0 0
Interleukin-17 signaling R-HSA-448424 7.353932e-01 0.133 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.367488e-01 0.133 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 7.379031e-01 0.132 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 7.381228e-01 0.132 0 0
COPI-mediated anterograde transport R-HSA-6807878 7.381228e-01 0.132 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 7.385343e-01 0.132 0 0
Formation of axial mesoderm R-HSA-9796292 7.385343e-01 0.132 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 7.385343e-01 0.132 0 0
Processing of SMDT1 R-HSA-8949664 7.385343e-01 0.132 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 7.385343e-01 0.132 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 7.385343e-01 0.132 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 7.385343e-01 0.132 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 7.385343e-01 0.132 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 7.385343e-01 0.132 0 0
Interleukin-6 signaling R-HSA-1059683 7.385343e-01 0.132 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 7.385343e-01 0.132 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.418071e-01 0.130 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 7.418071e-01 0.130 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 7.418071e-01 0.130 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 7.418071e-01 0.130 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 7.418071e-01 0.130 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.438737e-01 0.129 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.438737e-01 0.129 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 7.482870e-01 0.126 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 7.482870e-01 0.126 0 0
Insulin receptor recycling R-HSA-77387 7.482870e-01 0.126 0 0
Inflammasomes R-HSA-622312 7.482870e-01 0.126 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 7.518630e-01 0.124 0 0
IRS-mediated signalling R-HSA-112399 7.528406e-01 0.123 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 7.539354e-01 0.123 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 7.539354e-01 0.123 0 0
Signaling by FGFR R-HSA-190236 7.548779e-01 0.122 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 7.549160e-01 0.122 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 7.583839e-01 0.120 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 7.583839e-01 0.120 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 7.583839e-01 0.120 0 0
Hydrolysis of LPC R-HSA-1483115 7.583839e-01 0.120 0 0
Signaling by FGFR4 in disease R-HSA-5655291 7.583839e-01 0.120 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 7.583839e-01 0.120 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 7.583839e-01 0.120 0 0
Non-canonical inflammasome activation R-HSA-9686114 7.583839e-01 0.120 0 0
HDL assembly R-HSA-8963896 7.583839e-01 0.120 0 0
Acyl chain remodeling of CL R-HSA-1482798 7.583839e-01 0.120 0 0
Zinc transporters R-HSA-435354 7.583839e-01 0.120 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 7.583839e-01 0.120 0 0
Late endosomal microautophagy R-HSA-9615710 7.624194e-01 0.118 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 7.624194e-01 0.118 0 0
Termination of translesion DNA synthesis R-HSA-5656169 7.624194e-01 0.118 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 7.624194e-01 0.118 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 7.624194e-01 0.118 0 0
Signaling by FGFR4 R-HSA-5654743 7.656008e-01 0.116 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 7.656008e-01 0.116 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.677994e-01 0.115 0 0
DAP12 signaling R-HSA-2424491 7.758580e-01 0.110 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.758580e-01 0.110 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 7.758580e-01 0.110 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.758580e-01 0.110 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 7.761996e-01 0.110 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 7.767277e-01 0.110 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 7.767277e-01 0.110 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 7.767277e-01 0.110 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 7.767277e-01 0.110 0 0
Translesion synthesis by REV1 R-HSA-110312 7.767277e-01 0.110 0 0
Telomere C-strand synthesis initiation R-HSA-174430 7.767277e-01 0.110 0 0
Biotin transport and metabolism R-HSA-196780 7.767277e-01 0.110 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 7.767277e-01 0.110 0 0
Processive synthesis on the lagging strand R-HSA-69183 7.767277e-01 0.110 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 7.828864e-01 0.106 0 0
tRNA Aminoacylation R-HSA-379724 7.828864e-01 0.106 0 0
PI Metabolism R-HSA-1483255 7.860468e-01 0.105 0 0
Fanconi Anemia Pathway R-HSA-6783310 7.875785e-01 0.104 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 7.875785e-01 0.104 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 7.875785e-01 0.104 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 7.875785e-01 0.104 0 0
Signaling by FGFR3 R-HSA-5654741 7.875785e-01 0.104 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 7.875785e-01 0.104 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 7.886267e-01 0.103 0 0
Budding and maturation of HIV virion R-HSA-162588 7.886267e-01 0.103 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 7.886267e-01 0.103 0 0
Molecules associated with elastic fibres R-HSA-2129379 7.886267e-01 0.103 0 0
Translesion synthesis by POLI R-HSA-5656121 7.936798e-01 0.100 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 7.936798e-01 0.100 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 7.936798e-01 0.100 0 0
Activation of SMO R-HSA-5635838 7.936798e-01 0.100 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 7.936798e-01 0.100 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 7.936798e-01 0.100 0 0
Attachment and Entry R-HSA-9678110 7.936798e-01 0.100 0 0
Virus Assembly and Release R-HSA-168268 7.936798e-01 0.100 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 7.979105e-01 0.098 0 0
Diseases of DNA repair R-HSA-9675135 7.979105e-01 0.098 0 0
Signaling by TGFBR3 R-HSA-9839373 7.979105e-01 0.098 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 7.990247e-01 0.097 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 8.007497e-01 0.097 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.012528e-01 0.096 0 0
Neutrophil degranulation R-HSA-6798695 8.032236e-01 0.095 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.078184e-01 0.093 0 0
Mitochondrial biogenesis R-HSA-1592230 8.092830e-01 0.092 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.093458e-01 0.092 0 0
Translesion synthesis by POLK R-HSA-5655862 8.093458e-01 0.092 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 8.093458e-01 0.092 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 8.093458e-01 0.092 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 8.093458e-01 0.092 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 8.093458e-01 0.092 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 8.093458e-01 0.092 0 0
Coenzyme A biosynthesis R-HSA-196783 8.093458e-01 0.092 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 8.122514e-01 0.090 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.122514e-01 0.090 0 0
Signaling by Insulin receptor R-HSA-74752 8.136739e-01 0.090 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.158103e-01 0.088 0 0
GPER1 signaling R-HSA-9634597 8.173134e-01 0.088 0 0
Insulin receptor signalling cascade R-HSA-74751 8.183402e-01 0.087 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 8.217846e-01 0.085 0 0
Resolution of D-Loop Structures R-HSA-5693537 8.231563e-01 0.085 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.231563e-01 0.085 0 0
Circadian clock R-HSA-9909396 8.235456e-01 0.084 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 8.238231e-01 0.084 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 8.238231e-01 0.084 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.238231e-01 0.084 0 0
Glycogen storage diseases R-HSA-3229121 8.238231e-01 0.084 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.238231e-01 0.084 0 0
Choline catabolism R-HSA-6798163 8.238231e-01 0.084 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.238231e-01 0.084 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.238231e-01 0.084 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 8.295081e-01 0.081 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.334886e-01 0.079 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 8.334886e-01 0.079 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 8.334886e-01 0.079 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.334886e-01 0.079 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 8.334886e-01 0.079 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.334886e-01 0.079 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.334886e-01 0.079 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.334886e-01 0.079 0 0
Mitophagy R-HSA-5205647 8.334886e-01 0.079 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.334886e-01 0.079 0 0
Polo-like kinase mediated events R-HSA-156711 8.372019e-01 0.077 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 8.372019e-01 0.077 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 8.372019e-01 0.077 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 8.372019e-01 0.077 0 0
Synaptic adhesion-like molecules R-HSA-8849932 8.372019e-01 0.077 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 8.372019e-01 0.077 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 8.372019e-01 0.077 0 0
Toll-like Receptor Cascades R-HSA-168898 8.431822e-01 0.074 0 0
Regulation of Apoptosis R-HSA-169911 8.432724e-01 0.074 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.432724e-01 0.074 0 0
PERK regulates gene expression R-HSA-381042 8.432724e-01 0.074 0 0
Transferrin endocytosis and recycling R-HSA-917977 8.432724e-01 0.074 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.433049e-01 0.074 0 0
Hedgehog ligand biogenesis R-HSA-5358346 8.434336e-01 0.074 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 8.434336e-01 0.074 0 0
Hemostasis R-HSA-109582 8.485757e-01 0.071 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 8.495654e-01 0.071 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 8.495654e-01 0.071 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 8.495654e-01 0.071 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 8.495654e-01 0.071 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.495654e-01 0.071 0 0
Formation of the cornified envelope R-HSA-6809371 8.502611e-01 0.070 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 8.513910e-01 0.070 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 8.513910e-01 0.070 0 0
GPVI-mediated activation cascade R-HSA-114604 8.525314e-01 0.069 0 0
Regulation of insulin secretion R-HSA-422356 8.584038e-01 0.066 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.589934e-01 0.066 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 8.608016e-01 0.065 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 8.609907e-01 0.065 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 8.609907e-01 0.065 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 8.609907e-01 0.065 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 8.609907e-01 0.065 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 8.609907e-01 0.065 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 8.609907e-01 0.065 0 0
Glycogen synthesis R-HSA-3322077 8.609907e-01 0.065 0 0
Signaling by NODAL R-HSA-1181150 8.609907e-01 0.065 0 0
Acyl chain remodelling of PI R-HSA-1482922 8.609907e-01 0.065 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 8.609907e-01 0.065 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.612888e-01 0.065 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 8.624558e-01 0.064 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 8.662526e-01 0.062 0 0
Regulation of mitotic cell cycle R-HSA-453276 8.688410e-01 0.061 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 8.688410e-01 0.061 0 0
Hedgehog 'on' state R-HSA-5632684 8.688410e-01 0.061 0 0
Elastic fibre formation R-HSA-1566948 8.695674e-01 0.061 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.695674e-01 0.061 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.696844e-01 0.061 0 0
Parasite infection R-HSA-9664407 8.696844e-01 0.061 0 0
Leishmania phagocytosis R-HSA-9664417 8.696844e-01 0.061 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 8.715489e-01 0.060 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 8.715489e-01 0.060 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 8.715489e-01 0.060 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 8.715489e-01 0.060 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 8.715489e-01 0.060 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 8.715489e-01 0.060 0 0
Acyl chain remodelling of PG R-HSA-1482925 8.715489e-01 0.060 0 0
Basigin interactions R-HSA-210991 8.715489e-01 0.060 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 8.731805e-01 0.059 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 8.731805e-01 0.059 0 0
Paracetamol ADME R-HSA-9753281 8.731805e-01 0.059 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 8.773894e-01 0.057 0 0
Pentose phosphate pathway R-HSA-71336 8.773894e-01 0.057 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.797887e-01 0.056 0 0
Signaling by FGFR1 R-HSA-5654736 8.797887e-01 0.056 0 0
Ion homeostasis R-HSA-5578775 8.797887e-01 0.056 0 0
Ca2+ pathway R-HSA-4086398 8.808489e-01 0.055 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 8.813057e-01 0.055 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 8.813057e-01 0.055 0 0
Mitochondrial calcium ion transport R-HSA-8949215 8.813057e-01 0.055 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 8.813057e-01 0.055 0 0
Glutathione synthesis and recycling R-HSA-174403 8.813057e-01 0.055 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 8.813057e-01 0.055 0 0
Attachment and Entry R-HSA-9694614 8.813057e-01 0.055 0 0
Assembly Of The HIV Virion R-HSA-175474 8.813057e-01 0.055 0 0
ER-Phagosome pathway R-HSA-1236974 8.845082e-01 0.053 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.847763e-01 0.053 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.847763e-01 0.053 0 0
Translation R-HSA-72766 8.856416e-01 0.053 0 0
Interferon gamma signaling R-HSA-877300 8.899827e-01 0.051 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.903220e-01 0.050 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.903220e-01 0.050 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.903220e-01 0.050 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 8.903220e-01 0.050 0 0
Notch-HLH transcription pathway R-HSA-350054 8.903220e-01 0.050 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 8.903220e-01 0.050 0 0
Signaling by KIT in disease R-HSA-9669938 8.903220e-01 0.050 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 8.903220e-01 0.050 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 8.903220e-01 0.050 0 0
Cellular hexose transport R-HSA-189200 8.903220e-01 0.050 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.903220e-01 0.050 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.917491e-01 0.050 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 8.917491e-01 0.050 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 8.917491e-01 0.050 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 8.917491e-01 0.050 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.918899e-01 0.050 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.920923e-01 0.050 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.920923e-01 0.050 0 0
Signaling by TGFB family members R-HSA-9006936 8.937091e-01 0.049 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.978105e-01 0.047 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.983280e-01 0.047 0 0
HIV Transcription Initiation R-HSA-167161 8.983280e-01 0.047 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.983280e-01 0.047 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 8.983280e-01 0.047 0 0
Intra-Golgi traffic R-HSA-6811438 8.983280e-01 0.047 0 0
Translation of Structural Proteins R-HSA-9683701 8.983280e-01 0.047 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 8.986539e-01 0.046 0 0
Interleukin receptor SHC signaling R-HSA-912526 8.986539e-01 0.046 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 8.986539e-01 0.046 0 0
Translation of Structural Proteins R-HSA-9694635 9.020238e-01 0.045 0 0
Transmission across Chemical Synapses R-HSA-112315 9.026461e-01 0.044 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.063532e-01 0.043 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.063532e-01 0.043 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.063532e-01 0.043 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.063532e-01 0.043 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.063532e-01 0.043 0 0
Interleukin-6 family signaling R-HSA-6783589 9.063532e-01 0.043 0 0
Parasitic Infection Pathways R-HSA-9824443 9.066127e-01 0.043 0 0
Leishmania infection R-HSA-9658195 9.066127e-01 0.043 0 0
PCP/CE pathway R-HSA-4086400 9.067688e-01 0.043 0 0
Integrin cell surface interactions R-HSA-216083 9.067688e-01 0.043 0 0
Selenoamino acid metabolism R-HSA-2408522 9.075851e-01 0.042 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.079245e-01 0.042 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.084348e-01 0.042 0 0
Aquaporin-mediated transport R-HSA-445717 9.084348e-01 0.042 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.091914e-01 0.041 0 0
Neuronal System R-HSA-112316 9.100812e-01 0.041 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.103820e-01 0.041 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.103820e-01 0.041 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.113089e-01 0.040 0 0
Mitochondrial protein degradation R-HSA-9837999 9.120755e-01 0.040 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.134681e-01 0.039 0 0
Hyaluronan degradation R-HSA-2160916 9.134681e-01 0.039 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.134681e-01 0.039 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.134681e-01 0.039 0 0
Laminin interactions R-HSA-3000157 9.134681e-01 0.039 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.143928e-01 0.039 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.158940e-01 0.038 0 0
DAP12 interactions R-HSA-2172127 9.158940e-01 0.038 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.176765e-01 0.037 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.180476e-01 0.037 0 0
MET activates PTK2 signaling R-HSA-8874081 9.200428e-01 0.036 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 9.200428e-01 0.036 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.200428e-01 0.036 0 0
Urea cycle R-HSA-70635 9.200428e-01 0.036 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 9.200428e-01 0.036 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.210863e-01 0.036 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.210863e-01 0.036 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.210863e-01 0.036 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.210863e-01 0.036 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.259756e-01 0.033 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.259756e-01 0.033 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.259756e-01 0.033 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.261184e-01 0.033 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.261184e-01 0.033 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.305779e-01 0.031 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.317326e-01 0.031 0 0
Pyroptosis R-HSA-5620971 9.317326e-01 0.031 0 0
FOXO-mediated transcription R-HSA-9614085 9.336906e-01 0.030 0 0
Intraflagellar transport R-HSA-5620924 9.349085e-01 0.029 0 0
Gluconeogenesis R-HSA-70263 9.349085e-01 0.029 0 0
Ion channel transport R-HSA-983712 9.365947e-01 0.028 0 0
ABC-family proteins mediated transport R-HSA-382556 9.367911e-01 0.028 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.369205e-01 0.028 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.369205e-01 0.028 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 9.369205e-01 0.028 0 0
Platelet calcium homeostasis R-HSA-418360 9.369205e-01 0.028 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.379307e-01 0.028 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.389823e-01 0.027 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 9.389823e-01 0.027 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.389823e-01 0.027 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 9.397609e-01 0.027 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.417144e-01 0.026 0 0
Neurotransmitter clearance R-HSA-112311 9.417144e-01 0.026 0 0
Azathioprine ADME R-HSA-9748787 9.428132e-01 0.026 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.440749e-01 0.025 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.461443e-01 0.024 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.461443e-01 0.024 0 0
Cargo concentration in the ER R-HSA-5694530 9.461443e-01 0.024 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 9.461443e-01 0.024 0 0
Complex IV assembly R-HSA-9864848 9.464145e-01 0.024 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.472011e-01 0.024 0 0
Metabolism of cofactors R-HSA-8978934 9.479569e-01 0.023 0 0
Extracellular matrix organization R-HSA-1474244 9.481057e-01 0.023 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.497991e-01 0.022 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.502378e-01 0.022 0 0
DAG1 glycosylations R-HSA-8931838 9.502378e-01 0.022 0 0
Neurotransmitter release cycle R-HSA-112310 9.522541e-01 0.021 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 9.529790e-01 0.021 0 0
Nucleotide biosynthesis R-HSA-8956320 9.529790e-01 0.021 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.529790e-01 0.021 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 9.540203e-01 0.020 0 0
Cardiogenesis R-HSA-9733709 9.540203e-01 0.020 0 0
Regulation of necroptotic cell death R-HSA-5675482 9.540203e-01 0.020 0 0
Platelet homeostasis R-HSA-418346 9.550846e-01 0.020 0 0
Signaling by ERBB4 R-HSA-1236394 9.562771e-01 0.019 0 0
Integration of energy metabolism R-HSA-163685 9.565589e-01 0.019 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.575155e-01 0.019 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.575155e-01 0.019 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.575155e-01 0.019 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.575155e-01 0.019 0 0
Heme degradation R-HSA-189483 9.575155e-01 0.019 0 0
Signaling by NOTCH3 R-HSA-9012852 9.587705e-01 0.018 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.592085e-01 0.018 0 0
Protein folding R-HSA-391251 9.593197e-01 0.018 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.593197e-01 0.018 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.593197e-01 0.018 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.593428e-01 0.018 0 0
Stimuli-sensing channels R-HSA-2672351 9.593428e-01 0.018 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.607452e-01 0.017 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.607452e-01 0.017 0 0
Hyaluronan metabolism R-HSA-2142845 9.607452e-01 0.017 0 0
Signaling by NOTCH2 R-HSA-1980145 9.607452e-01 0.017 0 0
Signal amplification R-HSA-392518 9.607452e-01 0.017 0 0
UCH proteinases R-HSA-5689603 9.611134e-01 0.017 0 0
Signaling by NOTCH1 R-HSA-1980143 9.611134e-01 0.017 0 0
tRNA processing R-HSA-72306 9.615058e-01 0.017 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.633386e-01 0.016 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.637296e-01 0.016 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.637296e-01 0.016 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.637296e-01 0.016 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.637296e-01 0.016 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.637296e-01 0.016 0 0
Cholesterol biosynthesis R-HSA-191273 9.654435e-01 0.015 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.656512e-01 0.015 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.664873e-01 0.015 0 0
Triglyceride catabolism R-HSA-163560 9.664873e-01 0.015 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.664873e-01 0.015 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.669343e-01 0.015 0 0
Degradation of AXIN R-HSA-4641257 9.690354e-01 0.014 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.690354e-01 0.014 0 0
Lysine catabolism R-HSA-71064 9.690354e-01 0.014 0 0
Metabolism of folate and pterines R-HSA-196757 9.690354e-01 0.014 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 9.704085e-01 0.013 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 9.704085e-01 0.013 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 9.704085e-01 0.013 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 9.704085e-01 0.013 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 9.704085e-01 0.013 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 9.706372e-01 0.013 0 0
Infectious disease R-HSA-5663205 9.713118e-01 0.013 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.713899e-01 0.013 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.713899e-01 0.013 0 0
Immune System R-HSA-168256 9.733885e-01 0.012 0 0
RAS processing R-HSA-9648002 9.735655e-01 0.012 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.735655e-01 0.012 0 0
Signaling by ALK R-HSA-201556 9.735655e-01 0.012 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.741145e-01 0.011 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.743636e-01 0.011 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.755758e-01 0.011 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.755758e-01 0.011 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.755758e-01 0.011 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.774334e-01 0.010 0 0
Maturation of spike protein R-HSA-9694548 9.774334e-01 0.010 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.774334e-01 0.010 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.791497e-01 0.009 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.791497e-01 0.009 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.798776e-01 0.009 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.802276e-01 0.009 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.806057e-01 0.009 0 0
Protein localization R-HSA-9609507 9.810479e-01 0.008 0 0
RSV-host interactions R-HSA-9833110 9.811945e-01 0.008 0 0
Kidney development R-HSA-9830369 9.815219e-01 0.008 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.822010e-01 0.008 0 0
Regulated Necrosis R-HSA-5218859 9.827338e-01 0.008 0 0
PPARA activates gene expression R-HSA-1989781 9.827768e-01 0.008 0 0
Proteasome assembly R-HSA-9907900 9.835550e-01 0.007 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.835550e-01 0.007 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.835550e-01 0.007 0 0
Downstream TCR signaling R-HSA-202424 9.842486e-01 0.007 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.843581e-01 0.007 0 0
Somitogenesis R-HSA-9824272 9.848061e-01 0.007 0 0
ECM proteoglycans R-HSA-3000178 9.859242e-01 0.006 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.859620e-01 0.006 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.868541e-01 0.006 0 0
Synthesis of PC R-HSA-1483191 9.870301e-01 0.006 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.880901e-01 0.005 0 0
Collagen formation R-HSA-1474290 9.884437e-01 0.005 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.885379e-01 0.005 0 0
Iron uptake and transport R-HSA-917937 9.892990e-01 0.005 0 0
SLC transporter disorders R-HSA-5619102 9.904258e-01 0.004 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.905498e-01 0.004 0 0
Disease R-HSA-1643685 9.908255e-01 0.004 0 0
ABC transporter disorders R-HSA-5619084 9.912980e-01 0.004 0 0
Neddylation R-HSA-8951664 9.915476e-01 0.004 0 0
G alpha (z) signalling events R-HSA-418597 9.931148e-01 0.003 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.932692e-01 0.003 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.932692e-01 0.003 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.936390e-01 0.003 0 0
Dectin-2 family R-HSA-5621480 9.941232e-01 0.003 0 0
Synthesis of PA R-HSA-1483166 9.941232e-01 0.003 0 0
Triglyceride metabolism R-HSA-8979227 9.949840e-01 0.002 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.949840e-01 0.002 0 0
Glutathione conjugation R-HSA-156590 9.953660e-01 0.002 0 0
Metabolism of polyamines R-HSA-351202 9.953660e-01 0.002 0 0
Pyruvate metabolism R-HSA-70268 9.956615e-01 0.002 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.957189e-01 0.002 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.960305e-01 0.002 0 0
Complex I biogenesis R-HSA-6799198 9.963461e-01 0.002 0 0
Gastrulation R-HSA-9758941 9.968057e-01 0.001 0 0
Keratinization R-HSA-6805567 9.969172e-01 0.001 0 0
Cardiac conduction R-HSA-5576891 9.969609e-01 0.001 0 0
Nicotinate metabolism R-HSA-196807 9.973385e-01 0.001 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.973385e-01 0.001 0 0
FCGR activation R-HSA-2029481 9.973491e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.976632e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.979016e-01 0.001 0 0
Peptide hormone metabolism R-HSA-2980736 9.979500e-01 0.001 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.980031e-01 0.001 0 0
Metabolism of porphyrins R-HSA-189445 9.980615e-01 0.001 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.982676e-01 0.001 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.983457e-01 0.001 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.985882e-01 0.001 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.987956e-01 0.001 0 0
Visual phototransduction R-HSA-2187338 9.990020e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.990070e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.991751e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.993642e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.994100e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.994596e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.995236e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.995252e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.995878e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.995878e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.997897e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.998206e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.998343e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.998794e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.998968e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999183e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999244e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999308e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999361e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999628e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999721e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999756e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999764e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999773e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999793e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999796e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999806e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999835e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999837e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999913e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999917e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999947e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999950e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999954e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999976e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999976e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999977e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999977e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999978e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999979e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999986e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999990e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999997e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999998e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999999e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999999e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways