IRAK4

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A5A3E0	S1068	Sugiyama	POTEF A26C1B	SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
A5A3E0	T949	Sugiyama	POTEF A26C1B	TVAsSSSLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
O00151	S31	Sugiyama	PDLIM1 CLIM1 CLP36	PGPWGFRLVGGKDFEQPLAIsRVtPGSKAALANLCIGDVIT
O14950	T160	Sugiyama	MYL12B MRLC2 MYLC2B	DELyREAPIDKKGNFNyIEFtRILKHGAKDKDD________
O14979	T165	Sugiyama	HNRNPDL HNRPDL JKTBP	QDDGKMFIGGLSWDTsKKDLtEyLSRFGEVVDCtIKTDPVT
O15212	T84	Sugiyama	PFDN6 HKE2 PFD6	LVKQELGEARAtVGKRLDyItAEIKRYESQLRDLERQsEQQ
O43399	S145	Sugiyama	TPD52L2	LyKKTQETLsQAGQKtsAALstVGsAIsRKLGDMRNsAtFK
O43399	S152	Sugiyama	TPD52L2	TLsQAGQKtsAALstVGsAIsRKLGDMRNsAtFKsFEDRVG
O43423	S100	Sugiyama	ANP32CP PP32R1	AEKCPNLTHLYLSGNKIKDLstIEPLKQLENLKSLDLFNCE
O60739	T43	Sugiyama	EIF1B	LPAGTEDyIHIRIQQRNGRKtLttVQGIADDyDKKKLVKAF
O60739	T45	Sugiyama	EIF1B	AGTEDyIHIRIQQRNGRKtLttVQGIADDyDKKKLVKAFKK
O60739	T46	Sugiyama	EIF1B	GTEDyIHIRIQQRNGRKtLttVQGIADDyDKKKLVKAFKKK
O60814	S39	Sugiyama	H2BC12 H2BFT HIRIP1 HIST1H2BK	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
O60841	S182	Sugiyama	EIF5B IF2 KIAA0741	DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O60841	S196	Sugiyama	EIF5B IF2 KIAA0741	ERsRINssGEsGDEsDEFLQsRKGQKKNQKNKPGPNIEsGN
O60925	S78	Sugiyama	PFDN1 PFD1	TNMYEGVGRMFILQSKEAIHsQLLEKQKIAEEKIKELEQKK
O75347	S103	Sugiyama	TBCA	ENEKDLEEAEEyKEARLVLDsVKLEA_______________
O75821	T190	Sugiyama	EIF3G EIF3S4	PYKDtLGPMQKELAEQLGLstGEKEKLPGELEPVQAtQNKt
O95218	T50	Sugiyama	ZRANB2 ZIS ZNF265	SCNRCGREKTTEAKMMKAGGtEIGKtLAEKSRGLFsANDWQ
O95218	T55	Sugiyama	ZRANB2 ZIS ZNF265	GREKTTEAKMMKAGGtEIGKtLAEKSRGLFsANDWQCKTCs
O95626	S104	Sugiyama	ANP32D PP32R2	AEKCPNLIHLNLSGNKIKDLstIEPLKKLENLESLDLFTCE
O95678	S162	Sugiyama	KRT75 K6HF KB18	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
P00338	S105	Sugiyama	LDHA PIG19	VTANsKLVIItAGARQQEGEsRLNLVQRNVNIFKFIIPNVV
P00338	T322	Sugiyama	LDHA PIG19	DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P02538	S176	Sugiyama	KRT6A K6A KRT6D	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075	T37	Sugiyama	ALDOA ALDA	sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04083	T223	Sugiyama	ANXA1 ANX1 LPC1	ARALyEAGERRKGtDVNVFNtILttRSyPQLRRVFQKYTKY
P04259	S176	Sugiyama	KRT6B K6B KRTL1	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406	T211	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	PsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtGM
P04792	S83	Sugiyama	HSPB1 HSP27 HSP28	IEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNH
P04792	S86	Sugiyama	HSPB1 HSP27 HSP28	PAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNHFAP
P05386	S104	Sugiyama	RPLP1 RRP1	tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387	S105	Sugiyama	RPLP2 D11S2243E RPP2	GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05387	S29	Sugiyama	RPLP2 D11S2243E RPP2	LAALGGNssPsAKDIKKILDsVGIEADDDRLNKVIsELNGK
P05455	T379	Sugiyama	SSB	GKKtKFAsDDEHDEHDENGAtGPVKRAREEtDKEEPASKQQ
P05787	S104	Sugiyama	KRT8 CYK8	IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P06733	T19	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	__MSILKIHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGA
P06733	T205	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06733	T26	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	IHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEA
P07195	S106	Sugiyama	LDHB	VtANSKIVVVtAGVRQQEGEsRLNLVQRNVNVFKFIIPQIV
P07195	S303	Sugiyama	LDHB	GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195	T302	Sugiyama	LDHB	YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07195	T323	Sugiyama	LDHB	sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07237	S449	Sugiyama	P4HB ERBA2L PDI PDIA1 PO4DB	ANEVEAVKVHsFPtLKFFPAsADRtVIDyNGERtLDGFKKF
P07237	T453	Sugiyama	P4HB ERBA2L PDI PDIA1 PO4DB	EAVKVHsFPtLKFFPAsADRtVIDyNGERtLDGFKKFLESG
P07900	S399	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNLVKK
P07900	S52	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900	T195	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	DTGEPMGRGTKVILHLKEDQtEyLEERRIKEIVKKHSQFIG
P08238	S391	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNIVKK
P08238	S468	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238	S497	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	KEtQKsIyyItGEsKEQVANsAFVERVRKRGFEVVyMtEPI
P08238	T190	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
P08729	S104	Sugiyama	KRT7 SCL	LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P08758	T10	Sugiyama	ANXA5 ANX5 ENX2 PP4	___________MAQVLRGtVtDFPGFDERADAEtLRKAMKG
P09382	T58	Sugiyama	LGALS1	DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P09496	S236	Sugiyama	CLTA	RLCDFNPKSSKQAKDVSRMRsVLIsLKQAPLVH________
P09496	S240	Sugiyama	CLTA	FNPKSSKQAKDVSRMRsVLIsLKQAPLVH____________
P09661	S226	Sugiyama	SNRPA1	NAIANAstLAEVERLKGLLQsGQIPGRERRsGPtDDGEEEM
P0CG38	S1068	Sugiyama	POTEI	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39	S1031	Sugiyama	POTEJ	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P10412	S36	Sugiyama	H1-4 H1F4 HIST1H1E	EKtPVKKKARKsAGAAKRKAsGPPVsELItKAVAASKERsG
P10412	S41	Sugiyama	H1-4 H1F4 HIST1H1E	KKKARKsAGAAKRKAsGPPVsELItKAVAASKERsGVsLAA
P10412	S55	Sugiyama	H1-4 H1F4 HIST1H1E	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P10412	S58	Sugiyama	H1-4 H1F4 HIST1H1E	PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P10412	S89	Sugiyama	H1-4 H1F4 HIST1H1E	AGyDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P10412	T45	Sugiyama	H1-4 H1F4 HIST1H1E	RKsAGAAKRKAsGPPVsELItKAVAASKERsGVsLAALKKA
P10412	T92	Sugiyama	H1-4 H1F4 HIST1H1E	DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P10809	T231	Sugiyama	HSPD1 HSP60	LEIIEGMKFDRGyIsPyFINtsKGQKCEFQDAyVLLsEKKI
P11142	S40	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142	T163	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142	T226	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142	T64	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	FtDtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQ
P11142	T66	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P11940	T191	Sugiyama	PABPC1 PAB1 PABP PABP1 PABPC2	GRFKSRKEREAELGARAKEFtNVyIKNFGEDMDDERLKDLF
P12035	S211	Sugiyama	KRT3	IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P13639	S23	Sugiyama	EEF2 EF2	NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639	T5	Sugiyama	EEF2 EF2	________________MVNFtVDQIRAIMDKKANIRNMsVI
P13647	S181	Sugiyama	KRT5	IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13984	T16	Sugiyama	GTF2F2 RAP30	_____MAERGELDLTGAKQNtGVWLVKVPKYLsQQWAKASG
P14598	S288	SIGNOR\|EPSD\|PSP	NCF1 NOXO2 SH3PXD1A	KDDVTGYFPSMyLQKsGQDVsQAQRQIKRGAPPRRssIRNA
P14598	S320	SIGNOR\|EPSD\|PSP	NCF1 NOXO2 SH3PXD1A	PRRssIRNAHsIHQRsRKRLsQDAYRRNsVRFLQQRRRQAR
P14598	S345	SIGNOR\|EPSD\|PSP	NCF1 NOXO2 SH3PXD1A	RRNsVRFLQQRRRQARPGPQsPGsPLEEERQtQRsKPQPAV
P14598	S348	EPSD\|PSP	NCF1 NOXO2 SH3PXD1A	sVRFLQQRRRQARPGPQsPGsPLEEERQtQRsKPQPAVPPR
P14598	S359	EPSD\|PSP	NCF1 NOXO2 SH3PXD1A	ARPGPQsPGsPLEEERQtQRsKPQPAVPPRPsADLILNRCs
P14598	S370	EPSD\|PSP	NCF1 NOXO2 SH3PXD1A	LEEERQtQRsKPQPAVPPRPsADLILNRCsESTKRKLASAV
P14598	T133	SIGNOR\|EPSD\|PSP	NCF1 NOXO2 SH3PXD1A	HLLDFFKVRPDDLKLPTDNQtKKPEtYLMPKDGKSTATDIt
P14598	T138	EPSD\|PSP	NCF1 NOXO2 SH3PXD1A	FKVRPDDLKLPTDNQtKKPEtYLMPKDGKSTATDItGPIIL
P14598	T153	EPSD\|PSP	NCF1 NOXO2 SH3PXD1A	tKKPEtYLMPKDGKSTATDItGPIILQTYRAIANYEKTSGS
P14598	T356	SIGNOR\|EPSD\|PSP	NCF1 NOXO2 SH3PXD1A	RRQARPGPQsPGsPLEEERQtQRsKPQPAVPPRPsADLILN
P14618	S205	Sugiyama	PKM OIP3 PK2 PK3 PKM2	VKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVsEKD
P14618	T195	Sugiyama	PKM OIP3 PK2 PK3 PKM2	yVDDGLISLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAA
P14618	T454	Sugiyama	PKM OIP3 PK2 PK3 PKM2	SGRSAHQVARYRPRAPIIAVtRNPQtARQAHLYRGIFPVLC
P14618	T459	Sugiyama	PKM OIP3 PK2 PK3 PKM2	HQVARYRPRAPIIAVtRNPQtARQAHLYRGIFPVLCKDPVQ
P14625	S172	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	VGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSELI
P14625	T675	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	sGNMERIMKAQAYQtGKDIstNyyAsQKKTFEINPRHPLIR
P15311	S535	Sugiyama	EZR VIL2	EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15311	T533	Sugiyama	EZR VIL2	NEEKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDII
P15880	T285	Sugiyama	RPS2 RPS4	PyQEFtDHLVKtHtRVsVQRtQAPAVATt____________
P16401	S92	Sugiyama	H1-5 H1F5 HIST1H1B	GGYDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P16401	T95	Sugiyama	H1-5 H1F5 HIST1H1B	DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P16402	S37	Sugiyama	H1-3 H1F3 HIST1H1D	KtPVKKKAKKAGATAGKRKAsGPPVsELItKAVAASKERsG
P16402	S42	Sugiyama	H1-3 H1F3 HIST1H1D	KKAKKAGATAGKRKAsGPPVsELItKAVAASKERsGVsLAA
P16402	S56	Sugiyama	H1-3 H1F3 HIST1H1D	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16402	S59	Sugiyama	H1-3 H1F3 HIST1H1D	PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P16402	S90	Sugiyama	H1-3 H1F3 HIST1H1D	AGyDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P16402	T46	Sugiyama	H1-3 H1F3 HIST1H1D	KAGATAGKRKAsGPPVsELItKAVAASKERsGVsLAALKKA
P16402	T93	Sugiyama	H1-3 H1F3 HIST1H1D	DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P16403	S36	Sugiyama	H1-2 H1F2 HIST1H1C	EKAPVKKKAAKKAGGtPRKAsGPPVsELItKAVAASKERsG
P16403	S41	Sugiyama	H1-2 H1F2 HIST1H1C	KKKAAKKAGGtPRKAsGPPVsELItKAVAASKERsGVsLAA
P16403	S55	Sugiyama	H1-2 H1F2 HIST1H1C	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403	S58	Sugiyama	H1-2 H1F2 HIST1H1C	PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P16403	S89	Sugiyama	H1-2 H1F2 HIST1H1C	AGyDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P16403	T45	Sugiyama	H1-2 H1F2 HIST1H1C	AKKAGGtPRKAsGPPVsELItKAVAASKERsGVsLAALKKA
P16403	T92	Sugiyama	H1-2 H1F2 HIST1H1C	DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P17066	S42	Sugiyama	HSPA6 HSP70B'	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17987	S551	Sugiyama	TCP1 CCT1 CCTA	IKLHPESKDDKHGsyEDAVHsGALND_______________
P18621	T12	Sugiyama	RPL17	_________MVRysLDPENPtKsCKSRGSNLRVHFKNtRET
P19105	T159	Sugiyama	MYL12A MLCB MRLC3 RLC	DELyREAPIDKKGNFNyIEFtRILKHGAKDKDD________
P19338	S328	Sugiyama	NCL	NLFVGNLNFNKSAPELKtGIsDVFAKNDLAVVDVRIGMTRK
P19338	S460	Sugiyama	NCL	ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19338	T464	Sugiyama	NCL	KTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNSTWsGE
P20290	S126	Sugiyama	BTF3 NACB OK/SW-cl.8	VNMFTNQGTVIHFNNPKVQAsLAANtFtItGHAEtKQLTEM
P20290	T131	Sugiyama	BTF3 NACB OK/SW-cl.8	NQGTVIHFNNPKVQAsLAANtFtItGHAEtKQLTEMLPsIL
P20290	T133	Sugiyama	BTF3 NACB OK/SW-cl.8	GTVIHFNNPKVQAsLAANtFtItGHAEtKQLTEMLPsILNQ
P20290	T135	Sugiyama	BTF3 NACB OK/SW-cl.8	VIHFNNPKVQAsLAANtFtItGHAEtKQLTEMLPsILNQLG
P20290	T140	Sugiyama	BTF3 NACB OK/SW-cl.8	NPKVQAsLAANtFtItGHAEtKQLTEMLPsILNQLGADsLt
P22626	T140	Sugiyama	HNRNPA2B1 HNRPA2B1	KEDTEEHHLRDyFEEYGKIDtIEIItDRQsGKKRGFGFVtF
P23588	S122	Sugiyama	EIF4B	NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P26038	S527	Sugiyama	MSN	ERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHAE
P26038	T526	Sugiyama	MSN	EERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHA
P26373	S181	Sugiyama	RPL13 BBC1 OK/SW-cl.46	YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373	T148	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373	T151	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P26641	T287	Sugiyama	EEF1G EF1G PRO1608	EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P27348	S45	Sugiyama	YWHAQ	CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27348	Y48	Sugiyama	YWHAQ	AVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSIEQK
P27797	S52	Sugiyama	CALR CRTC	GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27797	T34	Sugiyama	CALR CRTC	LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P27816	S440	Sugiyama	MAP4	QANDIISSTEISSAEKVALssETEVALARDMtLPPETNVIL
P29692	S44	Sugiyama	EEF1D EF1D	RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P29692	T129	Sugiyama	EEF1D EF1D	EARLNVLEKssPGHRAtAPQtQHVsPMRQVEPPAKKPAtPA
P30086	S52	Sugiyama	PEBP1 PBP PEBP	AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P30086	S60	Sugiyama	PEBP1 PBP PEBP	VLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPDAPsRKDPK
P30086	S99	Sugiyama	PEBP1 PBP PEBP	PKYREWHHFLVVNMKGNDIssGtVLsDyVGsGPPKGtGLHR
P30086	T51	Sugiyama	PEBP1 PBP PEBP	GAAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDP
P30086	T65	Sugiyama	PEBP1 PBP PEBP	QVKNRPtsIsWDGLDsGKLytLVLtDPDAPsRKDPKYREWH
P30086	Y64	Sugiyama	PEBP1 PBP PEBP	tQVKNRPtsIsWDGLDsGKLytLVLtDPDAPsRKDPKYREW
P31327	T326	Sugiyama	CPS1	AKTYKMSMANRGQNQPVLNItNKQAFITAQNHGYALDNTLP
P31946	S47	Sugiyama	YWHAB	AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31946	Y50	Sugiyama	YWHAB	AVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSIEQK
P31947	S45	Sugiyama	SFN HME1	FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P31947	Y48	Sugiyama	SFN HME1	GAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsIEQK
P31948	T243	Sugiyama	STIP1	KQALKEKELGNDAYKKKDFDtALKHYDKAKELDPtNMtyIT
P32119	T142	Sugiyama	PRDX2 NKEFB TDPX1	EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P34931	S42	Sugiyama	HSPA1L	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P35269	S449	Sugiyama	GTF2F1 RAP74	PQsLsGKstPQPPsGKttPNsGDVQVTEDAVRRYLTRKPMT
P35579	S1915	Sugiyama	MYH9	KLQRELEDAtEtADAMNREVssLKNKLRRGDLPFVVPRRMA
P35579	T1745	Sugiyama	MYH9	RRLEARIAQLEEELEEEQGNtELINDRLKKANLQIDQINtD
P35579	T1904	Sugiyama	MYH9	EEAQRANAsRRKLQRELEDAtEtADAMNREVssLKNKLRRG
P35908	S191	Sugiyama	KRT2 KRT2A KRT2E	IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P37108	S25	Sugiyama	SRP14	EsEQFLtELTRLFQKCRTSGsVyItLKKYDGRTKPIPKKGt
P37802	S163	Sugiyama	TAGLN2 KIAA0120 CDABP0035	LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802	S94	Sugiyama	TAGLN2 KIAA0120 CDABP0035	QAPVKKIQAstMAFKQMEQIsQFLQAAERYGINTTDIFQtV
P37802	T180	Sugiyama	TAGLN2 KIAA0120 CDABP0035	RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P38646	S212	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	tVPAyFNDsQRQAtKDAGQIsGLNVLRVINEPTAAALAyGL
P38646	S89	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646	T116	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646	T120	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P38646	T86	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	CVAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAK
P38646	T94	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	QAKVLENAEGARttPsVVAFtADGERLVGMPAKRQAVtNPN
P38646	Y118	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	ERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIK
P39019	S59	Sugiyama	RPS19	LAKHKELAPyDENWFytRAAstARHLYLRGGAGVGsMTKIY
P39019	T55	Sugiyama	RPS19	DtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGsM
P39019	T60	Sugiyama	RPS19	AKHKELAPyDENWFytRAAstARHLYLRGGAGVGsMTKIYG
P39019	Y54	Sugiyama	RPS19	VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P39687	S104	Sugiyama	ANP32A C15orf1 LANP MAPM PHAP1	AEKCPNLTHLNLsGNKIKDLstIEPLKKLENLKsLDLFNCE
P41567	T43	Sugiyama	EIF1 SUI1	LPAGTEDyIHIRIQQRNGRKtLttVQGIADDyDKKKLVKAF
P41567	T45	Sugiyama	EIF1 SUI1	AGTEDyIHIRIQQRNGRKtLttVQGIADDyDKKKLVKAFKK
P41567	T46	Sugiyama	EIF1 SUI1	GTEDyIHIRIQQRNGRKtLttVQGIADDyDKKKLVKAFKKK
P42766	T59	Sugiyama	RPL35	GAASKLsKIRVVRKSIARVLtVINQtQKENLRKFYKGKKyK
P42766	T64	Sugiyama	RPL35	LsKIRVVRKSIARVLtVINQtQKENLRKFYKGKKyKPLDLR
P46776	S106	Sugiyama	RPL27A	tRVNAAKNKtGAAPIIDVVRsGyyKVLGKGKLPKQPVIVKA
P46776	S68	Sugiyama	RPL27A	yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46776	T72	Sugiyama	RPL27A	yFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRVNAAK
P46776	Y108	Sugiyama	RPL27A	VNAAKNKtGAAPIIDVVRsGyyKVLGKGKLPKQPVIVKAKF
P46777	S224	Sugiyama	RPL5 MSTP030	VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46778	T29	Sugiyama	RPL21	RGTRYMFSRPFRKHGVVPLAtyMRIYKKGDIVDIKGMGTVQ
P46779	S91	Sugiyama	RPL28	RKPAtsyVRttINKNARAtLsSIRHMIRKNKYRPDLRMAAI
P46779	T75	Sugiyama	RPL28	ADGKGVVVVIKRRSGQRKPAtsyVRttINKNARAtLsSIRH
P46779	T80	Sugiyama	RPL28	VVVVIKRRSGQRKPAtsyVRttINKNARAtLsSIRHMIRKN
P46779	T81	Sugiyama	RPL28	VVVIKRRSGQRKPAtsyVRttINKNARAtLsSIRHMIRKNK
P46783	T148	Sugiyama	RPS10	RRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ___
P47914	T151	Sugiyama	RPL29	DQTKAQAAAPAsVPAQAPKRtQAPtKAsE____________
P47914	T155	Sugiyama	RPL29	AQAAAPAsVPAQAPKRtQAPtKAsE________________
P47914	Y98	Sugiyama	RPL29	PKEVKPKIPKGVSRKLDRLAyIAHPKLGKRARARIAKGLRL
P48668	S176	Sugiyama	KRT6C KRT6E	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P48741	S42	Sugiyama	HSPA7 HSP70B	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P50991	T50	Sugiyama	CCT4 CCTD SRB	PAQIRFsNISAAKAVADAIRtsLGPKGMDKMIQDGKGDVtI
P51617	S376	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	IRAK1 IRAK	LGDFGLARFSRFAGssPsQssMVARTQTVRGtLAyLPEEyI
P51617	T387	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	IRAK1 IRAK	FAGssPsQssMVARTQTVRGtLAyLPEEyIKtGRLAVDTDT
P53999	S118	Sugiyama	SUB1 PC4 RPO2TC1	PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P53999	S9	Sugiyama	SUB1 PC4 RPO2TC1	____________MPKSKELVsssssGsDsDsEVDKKLKRKK
P54652	S41	Sugiyama	HSPA2	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P54652	T229	Sugiyama	HSPA2	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P55854	S27	Sugiyama	SUMO3 SMT3A SMT3H1	KEGVKTENDHINLKVAGQDGsVVQFKIKRHTPLSKLMKAYC
P57053	S39	Sugiyama	H2BC12L H2BFS H2BS1	VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P58876	S39	Sugiyama	H2BC5 H2BFB HIRIP2 HIST1H2BD	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P60174	T38	Sugiyama	TPI1 TPI	RKQsLGELIGtLNAAKVPADtEVVCAPPtAyIDFARQKLDP
P60174	T46	Sugiyama	TPI1 TPI	IGtLNAAKVPADtEVVCAPPtAyIDFARQKLDPKIAVAAQN
P60709	S368	Sugiyama	ACTB	sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709	T106	Sugiyama	ACTB	WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P60709	T249	Sugiyama	ACTB	tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P60709	T318	Sugiyama	ACTB	VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P60709	T324	Sugiyama	ACTB	tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P61254	T8	Sugiyama	RPL26	_____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P61254	T93	Sugiyama	RPL26	VYRKKyVIyIERVQREKANGttVHVGIHPSKVVITRLKLDK
P61254	T94	Sugiyama	RPL26	YRKKyVIyIERVQREKANGttVHVGIHPSKVVITRLKLDKD
P61513	S21	Sugiyama	RPL37A	MAKRTKKVGIVGKyGtRYGAsLRKMVKKIEISQHAKYTCSF
P61513	Y14	Sugiyama	RPL37A	_______MAKRTKKVGIVGKyGtRYGAsLRKMVKKIEISQH
P61604	S64	Sugiyama	HSPE1	AtVVAVGsGsKGKGGEIQPVsVKVGDKVLLPEyGGtKVVLD
P61604	T45	Sugiyama	HSPE1	TVTKGGIMLPEKSQGKVLQAtVVAVGsGsKGKGGEIQPVsV
P61956	S28	Sugiyama	SUMO2 SMT3B SMT3H2	EGVKtENNDHINLKVAGQDGsVVQFKIKRHTPLSKLMKAYC
P61981	S46	Sugiyama	YWHAG	AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P61981	T31	Sugiyama	YWHAG	ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P61981	Y49	Sugiyama	YWHAG	NVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSIEQK
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258	S148	Sugiyama	YWHAE	YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62258	S46	Sugiyama	YWHAE	SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62258	Y49	Sugiyama	YWHAE	KVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssIEQK
P62263	S137	Sugiyama	RPS14 PRO2640	RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62263	T140	Sugiyama	RPS14 PRO2640	ARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL_________
P62266	S45	Sugiyama	RPS23	KQYKKAHLGtALKANPFGGAsHAKGIVLEKVGVEAKQPNSA
P62269	S96	Sugiyama	RPS18 D6S218E	QYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLKK
P62277	S12	Sugiyama	RPS13	_________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280	T15	Sugiyama	RPS11	______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62316	T26	Sugiyama	SNRPD2 SNRPD1	KPKsEMtPEELQKREEEEFNtGPLsVLtQsVKNNtQVLINC
P62316	T33	Sugiyama	SNRPD2 SNRPD1	PEELQKREEEEFNtGPLsVLtQsVKNNtQVLINCRNNKKLL
P62424	T84	Sugiyama	RPL7A SURF-3 SURF3	QRQRAILyKRLKVPPAINQFtQALDRQTAtQLLKLAHKYRP
P62736	T251	Sugiyama	ACTA2 ACTSA ACTVS GIG46	tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P62736	T320	Sugiyama	ACTA2 ACTSA ACTVS GIG46	VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P62736	T326	Sugiyama	ACTA2 ACTSA ACTVS GIG46	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62750	T42	Sugiyama	RPL23A	LKAKKAVLKGVHSHKKKKIRtsPTFRRPKTLRLRRQPKYPR
P62807	S39	Sugiyama	H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI	VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA
P62851	S74	Sugiyama	RPS25	tyDKLCKEVPNYKLItPAVVsERLKIRGSLARAALQELLsK
P62857	S41	Sugiyama	RPS28	tGsQGQCtQVRVEFMDDtsRsIIRNVKGPVREGDVLtLLEs
P62857	S61	Sugiyama	RPS28	sIIRNVKGPVREGDVLtLLEsEREARRLR____________
P62857	T57	Sugiyama	RPS28	DtsRsIIRNVKGPVREGDVLtLLEsEREARRLR________
P62899	S15	Sugiyama	RPL31	______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62899	T107	Sugiyama	RPL31	RLSRKRNEDEDsPNKLytLVtyVPVttFKNLQtVNVDEN__
P62899	T22	Sugiyama	RPL31	APAKKGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRA
P62899	T26	Sugiyama	RPL31	KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62899	Y108	Sugiyama	RPL31	LSRKRNEDEDsPNKLytLVtyVPVttFKNLQtVNVDEN___
P62917	T135	Sugiyama	RPL8	CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917	T143	Sugiyama	RPL8	RGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVISSANR
P62917	Y133	Sugiyama	RPL8	VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62942	T22	Sugiyama	FKBP1A FKBP1 FKBP12	GVQVEtIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRD
P62942	T28	Sugiyama	FKBP1A FKBP1 FKBP12	IsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRDRNKPFK
P63104	S28	Sugiyama	YWHAZ	QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104	S45	Sugiyama	YWHAZ	CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63104	Y48	Sugiyama	YWHAZ	sVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssIEQK
P63173	T14	Sugiyama	RPL38	_______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63220	S68	Sugiyama	RPS21	GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____
P63261	S368	Sugiyama	ACTG1 ACTG	sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261	T106	Sugiyama	ACTG1 ACTG	WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P63261	T249	Sugiyama	ACTG1 ACTG	tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P63261	T318	Sugiyama	ACTG1 ACTG	VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P63261	T324	Sugiyama	ACTG1 ACTG	tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63267	T250	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P63267	T319	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P63267	T325	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P67809	S136	Sugiyama	YBX1 NSEP1 YB1	GEKGAEAANVtGPGGVPVQGsKYAADRNHYRRYPRRRGPPR
P67809	S167	Sugiyama	YBX1 NSEP1 YB1	RYPRRRGPPRNyQQNyQNsEsGEKNEGsEsAPEGQAQQRRP
P67809	S209	Sugiyama	YBX1 NSEP1 YB1	RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P67809	T108	Sugiyama	YBX1 NSEP1 YB1	QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P67809	T126	Sugiyama	YBX1 NSEP1 YB1	GEtVEFDVVEGEKGAEAANVtGPGGVPVQGsKYAADRNHYR
P67809	Y197	Sugiyama	YBX1 NSEP1 YB1	APEGQAQQRRPyRRRRFPPyyMRRPYGRRPQysNPPVQGEV
P67809	Y208	Sugiyama	YBX1 NSEP1 YB1	yRRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGE
P67809	Y72	Sugiyama	YBX1 NSEP1 YB1	KKVIATKVLGTVKWFNVRNGyGFINRNDtKEDVFVHQtAIK
P67809	Y99	Sugiyama	YBX1 NSEP1 YB1	DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
P68032	T251	Sugiyama	ACTC1 ACTC	tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68032	T320	Sugiyama	ACTC1 ACTC	VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68032	T326	Sugiyama	ACTC1 ACTC	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133	T251	Sugiyama	ACTA1 ACTA	tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68133	T320	Sugiyama	ACTA1 ACTA	VMSGGTTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68133	T326	Sugiyama	ACTA1 ACTA	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68363	T73	Sugiyama	TUBA1B	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363	Y83	Sugiyama	TUBA1B	PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
P83731	S38	Sugiyama	RPL24	GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P83731	T52	Sugiyama	RPL24	LNAKCEsAFLSKRNPRQINWtVLyRRKHKKGQsEEIQKKRT
P84098	S12	Sugiyama	RPL19	_________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
P84098	S13	Sugiyama	RPL19	________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEIA
P84098	S37	Sugiyama	RPL19	CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
P84098	T29	Sugiyama	RPL19	RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
Q01105	S166	Sugiyama	SET	yFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQT
Q01105	T169	Sugiyama	SET	NKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQNK
Q01546	S196	Sugiyama	KRT76 KRT2B KRT2P	IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q02539	S92	Sugiyama	H1-1 H1F1 HIST1H1A	AGyDVEKNNSRIKLGIKsLVsKGtLVQtKGtGAsGsFKLNK
Q02539	T95	Sugiyama	H1-1 H1F1 HIST1H1A	DVEKNNSRIKLGIKsLVsKGtLVQtKGtGAsGsFKLNKKAS
Q04760	T35	Sugiyama	GLO1	AALSCCSDADPSTKDFLLQQtMLRVKDPKKSLDFyTRVLGM
Q04917	S46	Sugiyama	YWHAH YWHA1	AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q04917	Y49	Sugiyama	YWHAH YWHA1	AVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSIEQK
Q05682	T169	Sugiyama	CALD1 CAD CDM	KEEKsESRQERyEIEETEtVtKSYQKNDWRDAEENKKEDKE
Q06323	S55	Sugiyama	PSME1 IFI5111	KKIsELDAFLKEPALNEANLsNLKAPLDIPVPDPVKEKEKE
Q06830	T143	Sugiyama	PRDX1 PAGA PAGB TDPX2	EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q13263	S784	Sugiyama	TRIM28 KAP1 RNF96 TIF1B	DVGRMFKQFNKLTEDKADVQsIIGLQRFFETRMNEAFGDTK
Q13310	T191	Sugiyama	PABPC4 APP1 PABP4	GRFKSRKEREAELGAKAKEFtNVyIKNFGEEVDDEsLKELF
Q13442	S19	Sugiyama	PDAP1 HASPP28	__MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEEE
Q13442	T18	Sugiyama	PDAP1 HASPP28	___MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEE
Q13442	T97	Sugiyama	PDAP1 HASPP28	VEGLIDIENPNRVAQttKKVtQLDLDGPKELSRREREEIEK
Q13765	S186	Sugiyama	NACA HSD48	sEEEEVDEtGVEVKDIELVMsQANVsRAKAVRALKNNSNDI
Q13765	S191	Sugiyama	NACA HSD48	VDEtGVEVKDIELVMsQANVsRAKAVRALKNNSNDIVNAIM
Q14152	S584	Sugiyama	EIF3A EIF3S10 KIAA0139	EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14152	T1378	Sugiyama	EIF3A EIF3S10 KIAA0139	AEKDREsLRRTKNEtDEDGWttVRR________________
Q14157	T23	Sugiyama	UBAP2L KIAA0144 NICE4	TSVGTNRARGNWEQPQNQNQtQHKQRPQATAEQIRLAQMIS
Q14157	T256	Sugiyama	UBAP2L KIAA0144 NICE4	AWRtAtEEWGtEDWNEDLsEtKIFtAsNVssVPLPAENVtI
Q14247	S332	Sugiyama	CTTN EMS1	VQKDRMDKNAstFEDVtQVssAyQKTVPVEAVtsKtsNIRA
Q14247	T145	Sugiyama	CTTN EMS1	FGVQMDRVDQsAVGFEyQGKtEKHAsQKDyssGFGGKyGVQ
Q14444	S97	Sugiyama	CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105	DYQERMNKGERLNQDQLDAVsKyQEVtNNLEFAKELQRsFM
Q14444	T303	Sugiyama	CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105	YTEQSEVESTEYVNRQFMAEtQFtsGEKEQVDEWTVETVEV
Q14568	S52	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14847	S99	Sugiyama	LASP1 MLN50	ELQsQVRYKEEFEKNKGKGFsVVADtPELQRIKKTQDQIsN
Q14978	S637	Sugiyama	NOLC1 KIAA0035 NS5ATP13	GEKRAssPFRRVREEEIEVDsRVADNsFDAKRGAAGDWGER
Q14CN4	S138	Sugiyama	KRT72 K6IRS2 KB35 KRT6 KRT6IRS2	IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15080	S67	Sugiyama	NCF4 SH3PXD4	TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15084	S230	Sugiyama	PDIA6 ERP5 P5 TXNDC7	QTKGKVKLAAVDAtVNQVLAsRYGIRGFPtIKIFQKGEsPV
Q15084	T223	Sugiyama	PDIA6 ERP5 P5 TXNDC7	AAsEVKEQTKGKVKLAAVDAtVNQVLAsRYGIRGFPtIKIF
Q15427	T14	Sugiyama	SF3B4 SAP49	_______MAAGPISERNQDAtVyVGGLDEKVSEPLLWELFL
Q3SY84	S143	Sugiyama	KRT71 K6IRS1 KB34 KRT6IRS1	IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q562R1	T250	Sugiyama	ACTBL2	RAAAssSPERsyELPDGQVItIGNERFRCPEAIFQPSFLGI
Q58FF6	T165	Sugiyama	HSP90AB4P	DHGEPIDRDTKVILHLKEDQtEyLEERWVKEVVKKHPQFIG
Q58FF7	S370	Sugiyama	HSP90AB3P HSP90BC	KETQKSTYYITGESKEQVANsAFVERVRKQGFEVVYMTEPI
Q58FF7	T169	Sugiyama	HSP90AB3P HSP90BC	DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
Q5QNW6	S39	Sugiyama	H2BC18 HIST2H2BF	VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q5XKE5	S155	Sugiyama	KRT79 K6L KB38 KRT6L	IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q6EEV6	S28	Sugiyama	SUMO4 SMT3H4	EEVKTENNNHINLKVAGQDGsVVQFKIKRQTPLSKLMKAYC
Q6FI81	S305	Sugiyama	CIAPIN1 CUA001 PRO0915	CAsCPyLGMPAFKPGEKVLLsDsNLHDA_____________
Q6P1R4	T365	Sugiyama	DUS1L DUS1	GSKEKAGARSKRALEEEEGGtEVLSKNKQKKQLRNPHKTFD
Q6P996	S721	Sugiyama	PDXDC1 KIAA0251	LPGQKPFKRsLRGsDALsEtssVsHIEDLEKVERLssGPEQ
Q6S8J3	S1068	Sugiyama	POTEE A26C1A POTE2	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6S8J3	T949	Sugiyama	POTEE A26C1A POTE2	tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q71U36	T73	Sugiyama	TUBA1A TUBA3	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36	Y83	Sugiyama	TUBA1A TUBA3	PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q7RTS7	S153	Sugiyama	KRT74 K6IRS4 KB37 KRT5C KRT6IRS4	IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z794	S177	Sugiyama	KRT77 KRT1B	IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86V81	T148	Sugiyama	ALYREF ALY BEF THOC4	EFGtLKKAAVHYDRsGRsLGtADVHFERKADALKAMKQYNG
Q86Y46	S145	Sugiyama	KRT73 K6IRS3 KB36 KRT6IRS3	IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8N6T3	S273	Sugiyama	ARFGAP1 ARF1GAP	KPAQEKVKEGKIFDDVSsGVsQLAsKVQGVGSKGWRDVttF
Q8N6T3	S277	Sugiyama	ARFGAP1 ARF1GAP	EKVKEGKIFDDVSsGVsQLAsKVQGVGSKGWRDVttFFsGK
Q8N6T3	T291	Sugiyama	ARFGAP1 ARF1GAP	GVsQLAsKVQGVGSKGWRDVttFFsGKAEGPLDsPSEGHSy
Q8NBS9	S426	Sugiyama	TXNDC5 TLP46 UNQ364/PRO700	KKVSEHSGGRDLDSLHRFVLsQAKDEL______________
Q8NFD5	S1744	Sugiyama	ARID1B BAF250B DAN15 KIAA1235 OSA2	ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q8WU90	T348	Sugiyama	ZC3H15 DFRP1 LEREPO4 HSPC303 HT010 MSTP012 PP730	sVNDIDLSLYIPRDVDEtGItVAsLERFSTYTsDKDENKLs
Q93079	S39	Sugiyama	H2BC9 H2BFJ HIST1H2BH	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q96B36	T233	Sugiyama	AKT1S1 PRAS40	PDLDRIAAsMRALVLREAEDtQVFGDLPRPRLNtsDFQKLK
Q96FA3	S293	SIGNOR\|EPSD\|PSP	PELI1 PRISM	QEINAARPQCPVGFNtLAFPsMKRKDVVDEKQPWVYLNCGH
Q96FA3	S70	EPSD\|PSP	PELI1 PRISM	NGVKPSTVHIACTPQAAKAIsNKDQHsIsYtLsRAQtVVVE
Q96FA3	S76	SIGNOR\|EPSD\|PSP	PELI1 PRISM	TVHIACTPQAAKAIsNKDQHsIsYtLsRAQtVVVEYTHDSN
Q96FA3	S78	SIGNOR\|EPSD\|PSP	PELI1 PRISM	HIACTPQAAKAIsNKDQHsIsYtLsRAQtVVVEYTHDSNTD
Q96FA3	S82	SIGNOR\|EPSD\|PSP	PELI1 PRISM	TPQAAKAIsNKDQHsIsYtLsRAQtVVVEYTHDSNTDMFQI
Q96FA3	T127	EPSD\|PSP	PELI1 PRISM	ESPIDFVVTDTVPGSQSNsDtQSVQSTISRFACRIICERNP
Q96FA3	T288	SIGNOR\|EPSD\|PSP	PELI1 PRISM	LEALRQEINAARPQCPVGFNtLAFPsMKRKDVVDEKQPWVY
Q96FA3	T80	SIGNOR\|EPSD\|PSP	PELI1 PRISM	ACTPQAAKAIsNKDQHsIsYtLsRAQtVVVEYTHDSNTDMF
Q96FA3	T86	SIGNOR\|EPSD\|PSP	PELI1 PRISM	AKAIsNKDQHsIsYtLsRAQtVVVEYTHDSNTDMFQIGRST
Q96IZ0	S259	Sugiyama	PAWR PAR4	SRYsRTDRSGFPRYNRDANVsGtLVSSstLEKKIEDLEKEV
Q96JH7	S1079	Sugiyama	VCPIP1 KIAA1850 VCIP135	DFSNSsTKTEPSVFTASSsNsELIRIAPGVVTMRDGRQLDP
Q99460	T830	Sugiyama	PSMD1	TFAYPAPLEVPKEKEKEKVStAVLsItAKAKKKEKEKEKKE
Q99460	T836	Sugiyama	PSMD1	PLEVPKEKEKEKVStAVLsItAKAKKKEKEKEKKEEEKMEV
Q99614	S155	Sugiyama	TTC1 TPR1	AESSYSRALEMCPSCFQKERsILFSNRAAARMKQDKKEMAI
Q99848	S269	Sugiyama	EBNA1BP2 EBP2	GFGGKKKGSKWNtREsyDDVssFRAKTAHGRGLKRPGKKGS
Q99877	S39	Sugiyama	H2BC15 H2BFD HIST1H2BN	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99879	S39	Sugiyama	H2BC14 H2BFE HIST1H2BM	INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99880	S39	Sugiyama	H2BC13 H2BFC HIST1H2BL	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q9BQE3	T73	Sugiyama	TUBA1C TUBA6	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3	Y83	Sugiyama	TUBA1C TUBA6	PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q9BYX7	S368	Sugiyama	POTEKP ACTBL3 FKSG30	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9BYX7	T249	Sugiyama	POTEKP ACTBL3 FKSG30	MAASSSSVEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q9H1E3	S14	Sugiyama	NUCKS1 NUCKS JC7	_______MSRPVRNRKVVDysQFQEsDDADEDyGRDsGPPt
Q9H1E3	T34	Sugiyama	NUCKS1 NUCKS JC7	sQFQEsDDADEDyGRDsGPPtKKIRSsPREAKNKRRsGKNs
Q9H444	T103	Sugiyama	CHMP4B C20orf178 SHAX1	DGtLstIEFQREALENANtNtEVLKNMGYAAKAMKAAHDNM
Q9NQ39	T159	Sugiyama	RPS10P5 RPS10L	RRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ___
Q9NSB2	S178	Sugiyama	KRT84 KRTHB4	AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9NVS9	T111	Sugiyama	PNPO	KPSARMLLLKGFGKDGFRFFtNFESRKGKELDSNPFASLVF
Q9NWZ3	S114	EPSD\|PSP\|Sugiyama	IRAK4	FAPASLLLPDAVPKTANTLPsKEAItVQQKQMPFCDKDRTL
Q9NWZ3	S150	EPSD\|PSP	IRAK4	KDRTLMTPVQNLEQSYMPPDsssPENKsLEVSDTRFHSFSF
Q9NWZ3	S151	EPSD\|PSP	IRAK4	DRTLMTPVQNLEQSYMPPDsssPENKsLEVSDTRFHSFSFY
Q9NWZ3	S152	EPSD\|PSP	IRAK4	RTLMTPVQNLEQSYMPPDsssPENKsLEVSDTRFHSFSFYE
Q9NWZ3	S186	Sugiyama	IRAK4	HSFSFYELKNVtNNFDERPIsVGGNKMGEGGFGVVYKGYVN
Q9NWZ3	S314	Sugiyama	IRAK4	GAANGINFLHENHHIHRDIKsANILLDEAFtAKISDFGLAR
Q9NWZ3	S346	GPS6\|SIGNOR\|EPSD\|PSP	IRAK4	KISDFGLARASEKFAQtVMtsRIVGTtAYMAPEALRGEITP
Q9NWZ3	S8	EPSD\|PSP	IRAK4	_____________MNKPItPsTYVRCLNVGLIRKLSDFIDP
Q9NWZ3	T119	Sugiyama	IRAK4	LLLPDAVPKTANTLPsKEAItVQQKQMPFCDKDRTLMTPVQ
Q9NWZ3	T177	Sugiyama	IRAK4	sLEVSDTRFHSFSFYELKNVtNNFDERPIsVGGNKMGEGGF
Q9NWZ3	T208	EPSD\|PSP\|Sugiyama	IRAK4	GGNKMGEGGFGVVYKGYVNNttVAVKKLAAMVDITtEELKQ
Q9NWZ3	T209	EPSD\|PSP\|Sugiyama	IRAK4	GNKMGEGGFGVVYKGYVNNttVAVKKLAAMVDITtEELKQQ
Q9NWZ3	T223	Sugiyama	IRAK4	GYVNNttVAVKKLAAMVDITtEELKQQFDQEIKVMAKCQHE
Q9NWZ3	T324	Sugiyama	IRAK4	ENHHIHRDIKsANILLDEAFtAKISDFGLARASEKFAQtVM
Q9NWZ3	T342	GPS6\|SIGNOR\|EPSD\|PSP	IRAK4	AFtAKISDFGLARASEKFAQtVMtsRIVGTtAYMAPEALRG
Q9NWZ3	T345	GPS6\|SIGNOR\|EPSD\|PSP	IRAK4	AKISDFGLARASEKFAQtVMtsRIVGTtAYMAPEALRGEIT
Q9NWZ3	T352	EPSD\|PSP	IRAK4	LARASEKFAQtVMtsRIVGTtAYMAPEALRGEITPKSDIYS
Q9NWZ3	T6	EPSD\|PSP	IRAK4	_______________MNKPItPsTYVRCLNVGLIRKLSDFI
Q9NWZ3	T62	Sugiyama	IRAK4	PSGDDRYNQFHIRRFEALLQtGKSPTSELLFDWGTTNCTVG
Q9UHV9	S22	Sugiyama	PFDN2 PFD2 HSPC231	AENSGRAGKssGSGAGKGAVsAEQVIAGFNRLRQEQRGLAS
Q9UII2	S63	Sugiyama	ATP5IF1 ATPI ATPIF1	AGGAFGKREQAEEERyFRAQsREQLAALKKHHEEEIVHHKK
Q9UMX5	T130	Sugiyama	NENF CIR2 SPUF	LTHDTTGLTAKELEALDEVFtKVYKAKYPIVGYTARRILNE
Q9UNX3	T8	Sugiyama	RPL26L1 RPL26P1	_____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Q9UNX3	T93	Sugiyama	RPL26L1 RPL26P1	VYRKKyVIyIERVQREKANGttVHVGIHPSKVVITRLKLDK
Q9UNX3	T94	Sugiyama	RPL26L1 RPL26P1	YRKKyVIyIERVQREKANGttVHVGIHPSKVVITRLKLDKD
Q9Y266	T145	Sugiyama	NUDC	AENHEAQLKNGsLDsPGKQDtEEDEEEDEKDKGKLKPNLGN
Q9Y2B0	S115	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	QIDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKF
Q9Y2B0	S116	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	IDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKFA
Q9Y2B0	S65	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2T7	T143	Sugiyama	YBX2 CSDA3 MSY2	QtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEATNVTGP
Q9Y2T7	Y107	Sugiyama	YBX2 CSDA3 MSY2	KPVLAIQVLGTVKWFNVRNGyGFINRNDtKEDVFVHQtAIK
Q9Y2V2	T45	Sugiyama	CARHSP1	RsRERsPsPLRGNVVPsPLPtRRtRtFsAtVRASQGPVYKG
Q9Y2V2	T48	Sugiyama	CARHSP1	ERsPsPLRGNVVPsPLPtRRtRtFsAtVRASQGPVYKGVCK
Q9Y3U8	S91	Sugiyama	RPL36	KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Q9Y608	S25	Sugiyama	LRRFIP2	ASGRKRTPVKDRFsAEDEALsNIAREAEARLAAKRAARAEA
Q9Y6W5	S442	Sugiyama	WASF2 WAVE2	DTTKPKSSLPAVSDARSDLLsAIRQGFQLRRVEEQREQEKR

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p	ref_path	ref_path_lowest
Signal Transduction	R-HSA-162582	4.888645e-12	11.311	1	0
Cell Cycle	R-HSA-1640170	9.383494e-12	11.028	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	5.346376e-09	8.272	0	0
Cell Cycle, Mitotic	R-HSA-69278	8.175280e-09	8.087	0	0
Axon guidance	R-HSA-422475	3.975835e-07	6.401	0	0
Nervous system development	R-HSA-9675108	1.708916e-06	5.767	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	2.611038e-06	5.583	0	0
Mitotic Prometaphase	R-HSA-68877	4.920186e-06	5.308	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	5.529771e-06	5.257	0	0
Signaling by ERBB2	R-HSA-1227986	7.375732e-06	5.132	0	0
Regulation of TP53 Activity	R-HSA-5633007	9.071186e-06	5.042	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	9.528265e-06	5.021	0	0
Signaling by VEGF	R-HSA-194138	9.966578e-06	5.001	0	0
Generic Transcription Pathway	R-HSA-212436	1.312207e-05	4.882	0	0
Cell Cycle Checkpoints	R-HSA-69620	1.477366e-05	4.831	0	0
Signalling to ERKs	R-HSA-187687	1.574221e-05	4.803	0	0
EPH-Ephrin signaling	R-HSA-2682334	2.733261e-05	4.563	0	0
p38MAPK events	R-HSA-171007	2.898245e-05	4.538	0	0
Gene expression (Transcription)	R-HSA-74160	3.573429e-05	4.447	0	0
Mitotic Anaphase	R-HSA-68882	3.866914e-05	4.413	0	0
Signalling to RAS	R-HSA-167044	4.228616e-05	4.374	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	4.181730e-05	4.379	0	0
RNA Polymerase II Transcription	R-HSA-73857	4.678096e-05	4.330	0	0
Semaphorin interactions	R-HSA-373755	4.730005e-05	4.325	0	0
M Phase	R-HSA-68886	6.132261e-05	4.212	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	6.950986e-05	4.158	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	7.178347e-05	4.144	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	8.155730e-05	4.089	0	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	9.617269e-05	4.017	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	1.157422e-04	3.937	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.157422e-04	3.937	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.137106e-04	3.944	0	0
G alpha (12/13) signalling events	R-HSA-416482	1.157422e-04	3.937	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	1.523617e-04	3.817	0	0
Signaling by Interleukins	R-HSA-449147	1.515599e-04	3.819	1	0
Sema4D in semaphorin signaling	R-HSA-400685	1.574549e-04	3.803	0	0
Signaling by PTK6	R-HSA-8848021	1.688846e-04	3.772	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	1.688846e-04	3.772	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.893336e-04	3.723	0	0
mRNA Splicing	R-HSA-72172	1.879865e-04	3.726	0	0
ESR-mediated signaling	R-HSA-8939211	1.787575e-04	3.748	0	0
Recycling pathway of L1	R-HSA-437239	1.962185e-04	3.707	0	0
L1CAM interactions	R-HSA-373760	2.182625e-04	3.661	0	0
Oncogenic MAPK signaling	R-HSA-6802957	2.742942e-04	3.562	0	0
Amplification of signal from the kinetochores	R-HSA-141424	3.079052e-04	3.512	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	3.079052e-04	3.512	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	3.152321e-04	3.501	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	3.431799e-04	3.464	0	0
Kinesins	R-HSA-983189	3.795051e-04	3.421	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	4.269634e-04	3.370	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	4.628900e-04	3.335	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	4.628900e-04	3.335	0	0
EPHB-mediated forward signaling	R-HSA-3928662	4.600925e-04	3.337	0	0
MAPK family signaling cascades	R-HSA-5683057	4.449535e-04	3.352	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	4.600925e-04	3.337	0	0
Separation of Sister Chromatids	R-HSA-2467813	5.028046e-04	3.299	0	0
G2/M Transition	R-HSA-69275	5.311939e-04	3.275	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	5.343479e-04	3.272	0	0
Signaling by ALK in cancer	R-HSA-9700206	5.343479e-04	3.272	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	5.960806e-04	3.225	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	6.249583e-04	3.204	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	6.156880e-04	3.211	0	0
Mitotic G2-G2/M phases	R-HSA-453274	6.106536e-04	3.214	0	0
Apoptotic execution phase	R-HSA-75153	6.252542e-04	3.204	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	6.316407e-04	3.200	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	6.316407e-04	3.200	0	0
Polo-like kinase mediated events	R-HSA-156711	6.316407e-04	3.200	0	0
Developmental Biology	R-HSA-1266738	6.627595e-04	3.179	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	8.106720e-04	3.091	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	9.193047e-04	3.037	0	0
RAF/MAP kinase cascade	R-HSA-5673001	9.856679e-04	3.006	0	0
Cardiac conduction	R-HSA-5576891	9.838141e-04	3.007	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	9.920685e-04	3.003	0	0
Post NMDA receptor activation events	R-HSA-438064	1.093937e-03	2.961	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	1.143740e-03	2.942	0	0
RAF activation	R-HSA-5673000	1.143075e-03	2.942	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.184108e-03	2.927	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	1.337502e-03	2.874	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	1.418088e-03	2.848	0	0
FOXO-mediated transcription	R-HSA-9614085	1.569663e-03	2.804	0	0
Estrogen-dependent gene expression	R-HSA-9018519	1.566146e-03	2.805	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	1.576422e-03	2.802	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	1.499336e-03	2.824	1	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	1.648476e-03	2.783	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	1.648476e-03	2.783	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	1.675429e-03	2.776	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	1.716747e-03	2.765	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	2.029194e-03	2.693	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	2.029194e-03	2.693	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	2.029194e-03	2.693	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	2.029194e-03	2.693	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	2.029194e-03	2.693	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	2.029194e-03	2.693	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	2.029194e-03	2.693	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	2.029194e-03	2.693	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	2.029194e-03	2.693	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	2.029194e-03	2.693	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	2.029194e-03	2.693	0	0
Signaling by RAS mutants	R-HSA-6802949	2.164183e-03	2.665	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	2.164183e-03	2.665	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	2.164183e-03	2.665	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	2.164183e-03	2.665	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	2.086990e-03	2.680	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	2.083603e-03	2.681	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	1.968640e-03	2.706	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	2.200381e-03	2.658	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	2.200381e-03	2.658	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	2.528007e-03	2.597	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	2.528007e-03	2.597	0	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	2.463134e-03	2.609	0	0
NRAGE signals death through JNK	R-HSA-193648	2.360902e-03	2.627	0	0
Interleukin-12 signaling	R-HSA-9020591	2.467837e-03	2.608	0	0
Death Receptor Signaling	R-HSA-73887	2.698739e-03	2.569	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	2.719216e-03	2.566	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	2.797674e-03	2.553	0	0
Muscle contraction	R-HSA-397014	2.890788e-03	2.539	0	0
Interleukin-12 family signaling	R-HSA-447115	2.917641e-03	2.535	0	0
Integrin signaling	R-HSA-354192	3.176476e-03	2.498	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	3.040191e-03	2.517	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	3.055968e-03	2.515	0	0
Selective autophagy	R-HSA-9663891	3.193725e-03	2.496	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	3.257534e-03	2.487	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	3.322116e-03	2.479	0	0
SHC-related events triggered by IGF1R	R-HSA-2428933	3.322116e-03	2.479	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	3.322116e-03	2.479	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	3.322116e-03	2.479	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	3.322116e-03	2.479	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	3.322116e-03	2.479	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	3.322116e-03	2.479	0	0
The NLRP3 inflammasome	R-HSA-844456	3.987007e-03	2.399	0	0
Signaling by NTRKs	R-HSA-166520	3.877521e-03	2.411	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	4.268453e-03	2.370	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	4.268453e-03	2.370	0	0
MITF-M-dependent gene expression	R-HSA-9856651	4.408346e-03	2.356	0	0
PIP3 activates AKT signaling	R-HSA-1257604	4.472477e-03	2.349	1	1
Activation of RAS in B cells	R-HSA-1169092	4.996224e-03	2.301	0	0
Adrenoceptors	R-HSA-390696	4.996224e-03	2.301	0	0
Post-chaperonin tubulin folding pathway	R-HSA-389977	4.842160e-03	2.315	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	4.585115e-03	2.339	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	4.959908e-03	2.305	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	4.912603e-03	2.309	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	4.996224e-03	2.301	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	4.710531e-03	2.327	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	4.971413e-03	2.304	0	0
Hemostasis	R-HSA-109582	5.318443e-03	2.274	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	5.446461e-03	2.264	0	0
G2/M DNA damage checkpoint	R-HSA-69473	5.457447e-03	2.263	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	5.514034e-03	2.259	0	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	6.747504e-03	2.171	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	6.747504e-03	2.171	0	0
ALK mutants bind TKIs	R-HSA-9700645	6.747504e-03	2.171	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	6.765219e-03	2.170	0	0
Adenylate cyclase inhibitory pathway	R-HSA-170670	6.765219e-03	2.170	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	6.765219e-03	2.170	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	6.765219e-03	2.170	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	6.102840e-03	2.214	0	0
Cellular Senescence	R-HSA-2559583	6.744240e-03	2.171	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	6.747504e-03	2.171	0	0
Intracellular signaling by second messengers	R-HSA-9006925	6.392031e-03	2.194	1	0
Regulation of gene expression in beta cells	R-HSA-210745	6.415988e-03	2.193	0	0
Diseases of DNA repair	R-HSA-9675135	6.850405e-03	2.164	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	6.894115e-03	2.162	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	6.894115e-03	2.162	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	6.894115e-03	2.162	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	6.894115e-03	2.162	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	6.894115e-03	2.162	0	0
Ion homeostasis	R-HSA-5578775	6.943991e-03	2.158	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	6.945628e-03	2.158	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	7.296279e-03	2.137	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	7.423365e-03	2.129	0	0
Signaling by KIT in disease	R-HSA-9669938	8.214631e-03	2.085	0	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	8.214631e-03	2.085	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	8.494554e-03	2.071	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	7.909888e-03	2.102	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	8.257902e-03	2.083	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	8.500069e-03	2.071	1	1
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	8.500069e-03	2.071	1	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	8.500069e-03	2.071	1	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	8.316355e-03	2.080	0	0
Co-stimulation by CD28	R-HSA-389356	8.554006e-03	2.068	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	8.668343e-03	2.062	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	8.863110e-03	2.052	0	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	8.863110e-03	2.052	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	8.863110e-03	2.052	0	0
PKR-mediated signaling	R-HSA-9833482	9.219024e-03	2.035	0	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	9.241878e-03	2.034	1	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	9.241878e-03	2.034	1	1
KEAP1-NFE2L2 pathway	R-HSA-9755511	9.556761e-03	2.020	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	9.818545e-03	2.008	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	1.011417e-02	1.995	0	0
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	1.123785e-02	1.949	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	1.114759e-02	1.953	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	1.070105e-02	1.971	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	1.123785e-02	1.949	0	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	1.120649e-02	1.951	1	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	1.048991e-02	1.979	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	1.120649e-02	1.951	1	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	1.011417e-02	1.995	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	1.114759e-02	1.953	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	1.133502e-02	1.946	0	0
Activated NTRK3 signals through RAS	R-HSA-9034864	1.137019e-02	1.944	0	0
Signaling by APC mutants	R-HSA-4839744	1.137019e-02	1.944	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.137019e-02	1.944	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.137019e-02	1.944	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.137019e-02	1.944	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.171464e-02	1.931	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	1.215247e-02	1.915	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	1.215247e-02	1.915	0	0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	1.215247e-02	1.915	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.237874e-02	1.907	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	1.299641e-02	1.886	0	0
Meiotic synapsis	R-HSA-1221632	1.420879e-02	1.847	0	0
Signal amplification	R-HSA-392518	1.428388e-02	1.845	0	0
Activated NTRK2 signals through RAS	R-HSA-9026519	1.429262e-02	1.845	0	0
Signaling by AMER1 mutants	R-HSA-4839748	1.429262e-02	1.845	0	0
Signaling by AXIN mutants	R-HSA-4839735	1.429262e-02	1.845	0	0
Transport of connexons to the plasma membrane	R-HSA-190872	1.445261e-02	1.840	0	0
Signaling by SCF-KIT	R-HSA-1433557	1.454587e-02	1.837	0	0
Signaling by FGFR4	R-HSA-5654743	1.454587e-02	1.837	0	0
Signaling by WNT	R-HSA-195721	1.485247e-02	1.828	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	1.489613e-02	1.827	0	0
Breakdown of the nuclear lamina	R-HSA-352238	1.490088e-02	1.827	0	0
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	1.490088e-02	1.827	0	0
Transport of glycerol from adipocytes to the liver by Aquaporins	R-HSA-432030	1.490088e-02	1.827	0	0
Myogenesis	R-HSA-525793	1.497263e-02	1.825	0	0
Cyclin D associated events in G1	R-HSA-69231	1.613427e-02	1.792	0	0
G1 Phase	R-HSA-69236	1.613427e-02	1.792	0	0
Oncogene Induced Senescence	R-HSA-2559585	1.606794e-02	1.794	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.747020e-02	1.758	0	0
STING mediated induction of host immune responses	R-HSA-1834941	1.702779e-02	1.769	0	0
Apoptosis	R-HSA-109581	1.726882e-02	1.763	0	0
Signaling by LTK	R-HSA-9842663	1.765091e-02	1.753	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	1.765761e-02	1.753	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	1.765761e-02	1.753	0	0
Signaling by FGFR3	R-HSA-5654741	1.784422e-02	1.749	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	1.799277e-02	1.745	1	1
Regulation of TP53 Degradation	R-HSA-6804757	1.800438e-02	1.745	0	0
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	1.847401e-02	1.733	0	0
Signaling by EGFR	R-HSA-177929	1.871207e-02	1.728	0	0
Signaling by FGFR1	R-HSA-5654736	1.871207e-02	1.728	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	1.871207e-02	1.728	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	1.911787e-02	1.719	1	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	1.914675e-02	1.718	1	1
Inflammasomes	R-HSA-622312	1.949143e-02	1.710	0	0
Formation of definitive endoderm	R-HSA-9823730	1.989010e-02	1.701	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	2.009922e-02	1.697	0	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	2.146213e-02	1.668	0	0
Regulation of TP53 Expression	R-HSA-6804754	2.545256e-02	1.594	0	0
Diseases of cellular response to stress	R-HSA-9675132	2.545256e-02	1.594	0	0
Diseases of Cellular Senescence	R-HSA-9630747	2.545256e-02	1.594	0	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	2.545256e-02	1.594	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	2.424181e-02	1.615	0	0
SOS-mediated signalling	R-HSA-112412	2.424181e-02	1.615	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	2.424181e-02	1.615	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	2.305038e-02	1.637	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	2.305038e-02	1.637	0	0
SHC-mediated cascade:FGFR3	R-HSA-5654704	2.305038e-02	1.637	0	0
SHC-mediated cascade:FGFR4	R-HSA-5654719	2.651827e-02	1.576	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	2.651827e-02	1.576	0	0
Protein folding	R-HSA-391251	2.562694e-02	1.591	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	2.396138e-02	1.620	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	2.431358e-02	1.614	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	2.413035e-02	1.617	1	1
Cellular responses to mechanical stimuli	R-HSA-9855142	2.577396e-02	1.589	0	0
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization	R-HSA-180897	2.545256e-02	1.594	0	0
Phase 3 - rapid repolarisation	R-HSA-5576890	2.424181e-02	1.615	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	2.432923e-02	1.614	1	0
GPER1 signaling	R-HSA-9634597	2.374897e-02	1.624	0	0
Signaling by ALK	R-HSA-201556	2.478695e-02	1.606	0	0
Regulation of beta-cell development	R-HSA-186712	2.417020e-02	1.617	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	2.706365e-02	1.568	0	0
Aggrephagy	R-HSA-9646399	2.739050e-02	1.562	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	2.778909e-02	1.556	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	2.778909e-02	1.556	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	2.787964e-02	1.555	0	0
Downstream signal transduction	R-HSA-186763	2.787964e-02	1.555	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	2.885255e-02	1.540	1	0
S Phase	R-HSA-69242	2.982467e-02	1.525	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	2.982467e-02	1.525	1	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	2.985786e-02	1.525	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	3.049456e-02	1.516	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	3.049456e-02	1.516	0	0
SHC1 events in EGFR signaling	R-HSA-180336	3.049456e-02	1.516	0	0
p75NTR signals via NF-kB	R-HSA-193639	3.049456e-02	1.516	0	0
Erythropoietin activates RAS	R-HSA-9027284	3.049456e-02	1.516	0	0
Meiosis	R-HSA-1500620	3.064780e-02	1.514	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	3.067546e-02	1.513	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	3.084833e-02	1.511	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	3.093390e-02	1.510	0	0
G0 and Early G1	R-HSA-1538133	3.113256e-02	1.507	0	0
G2/M Checkpoints	R-HSA-69481	3.152782e-02	1.501	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	3.163846e-02	1.500	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	3.180673e-02	1.497	0	0
Axonal growth stimulation	R-HSA-209563	3.821956e-02	1.418	0	0
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	3.835037e-02	1.416	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	3.440874e-02	1.463	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	3.440874e-02	1.463	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	3.884395e-02	1.411	0	0
SHC-mediated cascade:FGFR1	R-HSA-5654688	3.884395e-02	1.411	0	0
MAP2K and MAPK activation	R-HSA-5674135	3.314118e-02	1.480	0	0
Chaperonin-mediated protein folding	R-HSA-390466	3.709866e-02	1.431	0	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	3.884395e-02	1.411	0	0
Signaling by RAF1 mutants	R-HSA-9656223	3.314118e-02	1.480	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	3.488425e-02	1.457	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	3.462355e-02	1.461	0	0
Activation of ATR in response to replication stress	R-HSA-176187	3.462355e-02	1.461	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	3.309119e-02	1.480	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	3.314118e-02	1.480	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	3.936236e-02	1.405	0	0
Activation of the AP-1 family of transcription factors	R-HSA-450341	3.835037e-02	1.416	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	3.440874e-02	1.463	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	3.462355e-02	1.461	0	0
mRNA Editing	R-HSA-75072	3.835037e-02	1.416	0	0
G-protein beta:gamma signalling	R-HSA-397795	3.462355e-02	1.461	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	3.673333e-02	1.435	0	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	4.069729e-02	1.390	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	4.069729e-02	1.390	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	3.884395e-02	1.411	0	0
Neurodegenerative Diseases	R-HSA-8863678	3.884395e-02	1.411	0	0
Programmed Cell Death	R-HSA-5357801	4.034471e-02	1.394	0	0
AURKA Activation by TPX2	R-HSA-8854518	4.111924e-02	1.386	0	0
SHC1 events in ERBB4 signaling	R-HSA-1250347	4.145914e-02	1.382	0	0
Transcriptional regulation of testis differentiation	R-HSA-9690406	4.145914e-02	1.382	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	4.175747e-02	1.379	0	0
Mitophagy	R-HSA-5205647	4.233825e-02	1.373	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	4.233825e-02	1.373	0	0
Netrin-1 signaling	R-HSA-373752	4.318784e-02	1.365	0	0
Cellular responses to stimuli	R-HSA-8953897	4.356253e-02	1.361	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	4.361199e-02	1.360	0	0
Hedgehog 'off' state	R-HSA-5610787	4.383525e-02	1.358	0	0
G-protein mediated events	R-HSA-112040	4.406374e-02	1.356	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	4.656947e-02	1.332	0	0
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	4.666451e-02	1.331	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	4.666451e-02	1.331	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	4.666451e-02	1.331	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	4.714614e-02	1.327	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	4.714614e-02	1.327	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	4.871581e-02	1.312	0	0
TRP channels	R-HSA-3295583	4.871581e-02	1.312	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	4.937954e-02	1.306	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	5.036837e-02	1.298	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	5.043298e-02	1.297	0	0
Signaling by TGFB family members	R-HSA-9006936	5.093468e-02	1.293	0	0
Drug resistance of KIT mutants	R-HSA-9669937	5.933728e-02	1.227	0	0
KIT mutants bind TKIs	R-HSA-9669921	5.933728e-02	1.227	0	0
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	5.933728e-02	1.227	0	0
Nilotinib-resistant KIT mutants	R-HSA-9669926	5.933728e-02	1.227	0	0
Imatinib-resistant KIT mutants	R-HSA-9669917	5.933728e-02	1.227	0	0
Loss of Function of TP53 in Cancer	R-HSA-9723907	5.933728e-02	1.227	0	0
Regorafenib-resistant KIT mutants	R-HSA-9669929	5.933728e-02	1.227	0	0
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	5.933728e-02	1.227	0	0
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	5.933728e-02	1.227	0	0
Masitinib-resistant KIT mutants	R-HSA-9669924	5.933728e-02	1.227	0	0
Dasatinib-resistant KIT mutants	R-HSA-9669914	5.933728e-02	1.227	0	0
Sunitinib-resistant KIT mutants	R-HSA-9669934	5.933728e-02	1.227	0	0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects	R-HSA-9646304	5.933728e-02	1.227	0	0
Sorafenib-resistant KIT mutants	R-HSA-9669936	5.933728e-02	1.227	0	0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects	R-HSA-9646303	5.933728e-02	1.227	0	0
AKT-mediated inactivation of FOXO1A	R-HSA-211163	5.290236e-02	1.277	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	5.290236e-02	1.277	0	0
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	5.290236e-02	1.277	0	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	5.290236e-02	1.277	0	0
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	6.922912e-02	1.160	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	5.578782e-02	1.253	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	6.155778e-02	1.211	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	6.921542e-02	1.160	0	0
Co-inhibition by CTLA4	R-HSA-389513	6.921542e-02	1.160	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	6.921542e-02	1.160	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	6.921542e-02	1.160	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	6.921542e-02	1.160	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	6.921542e-02	1.160	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	5.415706e-02	1.266	0	0
SHC-mediated cascade:FGFR2	R-HSA-5654699	5.415706e-02	1.266	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	5.681683e-02	1.246	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	5.353772e-02	1.271	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	5.317748e-02	1.274	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	5.317748e-02	1.274	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	6.605205e-02	1.180	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	5.317748e-02	1.274	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	5.437485e-02	1.265	0	0
Ephrin signaling	R-HSA-3928664	5.437485e-02	1.265	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	5.415706e-02	1.266	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	6.078875e-02	1.216	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	5.579309e-02	1.253	0	0
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	6.922912e-02	1.160	0	0
NF-kB is activated and signals survival	R-HSA-209560	6.568951e-02	1.183	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	6.949884e-02	1.158	0	0
Rap1 signalling	R-HSA-392517	6.155778e-02	1.211	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	6.155778e-02	1.211	0	0
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	6.922912e-02	1.160	0	0
Platelet calcium homeostasis	R-HSA-418360	6.605205e-02	1.180	0	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	5.578782e-02	1.253	0	0
DNA Repair	R-HSA-73894	6.860794e-02	1.164	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	6.604129e-02	1.180	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	5.501645e-02	1.260	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	5.373216e-02	1.270	0	0
Regulation of MITF-M dependent genes involved in invasion	R-HSA-9854909	6.922912e-02	1.160	0	0
Immune System	R-HSA-168256	7.005458e-02	1.155	1	0
NrCAM interactions	R-HSA-447038	6.922912e-02	1.160	0	0
Tie2 Signaling	R-HSA-210993	5.437485e-02	1.265	0	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	6.922912e-02	1.160	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	5.415706e-02	1.266	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	7.155059e-02	1.145	0	0
Attenuation phase	R-HSA-3371568	7.155059e-02	1.145	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	7.183479e-02	1.144	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	7.250280e-02	1.140	0	0
Adipogenesis	R-HSA-9843745	7.251695e-02	1.140	0	0
HSF1-dependent transactivation	R-HSA-3371571	7.365066e-02	1.133	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	7.377815e-02	1.132	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	7.377815e-02	1.132	0	0
GPCR downstream signalling	R-HSA-388396	7.633247e-02	1.117	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	7.633403e-02	1.117	0	0
p75NTR recruits signalling complexes	R-HSA-209543	7.633403e-02	1.117	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	7.633403e-02	1.117	0	0
Role of second messengers in netrin-1 signaling	R-HSA-418890	7.633403e-02	1.117	0	0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	7.633403e-02	1.117	0	0
GRB2 events in EGFR signaling	R-HSA-179812	7.633403e-02	1.117	0	0
MET activates RAS signaling	R-HSA-8851805	7.633403e-02	1.117	0	0
PKMTs methylate histone lysines	R-HSA-3214841	7.731582e-02	1.112	0	0
IGF1R signaling cascade	R-HSA-2428924	7.844890e-02	1.105	0	0
Ion transport by P-type ATPases	R-HSA-936837	7.844890e-02	1.105	0	0
mRNA 3'-end processing	R-HSA-72187	7.882540e-02	1.103	0	0
MHC class II antigen presentation	R-HSA-2132295	8.296423e-02	1.081	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	8.329221e-02	1.079	0	0
Cellular response to chemical stress	R-HSA-9711123	8.330826e-02	1.079	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	8.420614e-02	1.075	0	0
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	1.151570e-01	0.939	0	0
Defective Mismatch Repair Associated With PMS2	R-HSA-5632987	1.151570e-01	0.939	0	0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4	R-HSA-9630791	1.151570e-01	0.939	0	0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4	R-HSA-9632697	1.151570e-01	0.939	0	0
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	1.151570e-01	0.939	0	0
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	1.151570e-01	0.939	0	0
Defective Mismatch Repair Associated With MLH1	R-HSA-5545483	1.151570e-01	0.939	0	0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function	R-HSA-9645722	1.151570e-01	0.939	0	0
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	8.695348e-02	1.061	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	8.695348e-02	1.061	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	8.695348e-02	1.061	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	8.695348e-02	1.061	0	0
PTK6 Regulates Cell Cycle	R-HSA-8849470	8.695348e-02	1.061	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	1.058525e-01	0.975	0	0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	1.257246e-01	0.901	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	1.257246e-01	0.901	0	0
Formation of axial mesoderm	R-HSA-9796292	8.768203e-02	1.057	0	0
Adenylate cyclase activating pathway	R-HSA-170660	8.768203e-02	1.057	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	8.768203e-02	1.057	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	8.768203e-02	1.057	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	9.969128e-02	1.001	0	0
Spry regulation of FGF signaling	R-HSA-1295596	1.123174e-01	0.950	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	1.255146e-01	0.901	0	0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	1.255146e-01	0.901	0	0
Phase 4 - resting membrane potential	R-HSA-5576886	1.255146e-01	0.901	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	9.493280e-02	1.023	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	8.639452e-02	1.064	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	1.244724e-01	0.905	0	0
Striated Muscle Contraction	R-HSA-390522	1.015723e-01	0.993	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	8.960749e-02	1.048	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	1.099066e-01	0.959	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	1.099066e-01	0.959	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	1.179813e-01	0.928	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	1.179813e-01	0.928	0	0
DNA Double Strand Break Response	R-HSA-5693606	9.349488e-02	1.029	0	0
Signaling by FGFR2	R-HSA-5654738	9.539022e-02	1.020	0	0
Free fatty acids regulate insulin secretion	R-HSA-400451	1.043760e-01	0.981	0	0
Activation of GABAB receptors	R-HSA-991365	8.960749e-02	1.048	0	0
Developmental Cell Lineages	R-HSA-9734767	1.073683e-01	0.969	0	0
RET signaling	R-HSA-8853659	1.266265e-01	0.897	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	8.695348e-02	1.061	0	0
Formation of lateral plate mesoderm	R-HSA-9758920	8.695348e-02	1.061	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	8.695348e-02	1.061	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	1.257246e-01	0.901	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	8.591529e-02	1.066	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	1.100754e-01	0.958	0	0
GABA B receptor activation	R-HSA-977444	8.960749e-02	1.048	0	0
Homology Directed Repair	R-HSA-5693538	1.164662e-01	0.934	0	0
Telomere C-strand synthesis initiation	R-HSA-174430	1.123174e-01	0.950	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	9.112793e-02	1.040	0	0
Long-term potentiation	R-HSA-9620244	1.244724e-01	0.905	0	0
Nuclear import of Rev protein	R-HSA-180746	1.096268e-01	0.960	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	9.558130e-02	1.020	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.159370e-01	0.936	0	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	1.255146e-01	0.901	0	0
G alpha (q) signalling events	R-HSA-416476	1.102674e-01	0.958	0	0
Epigenetic regulation of gene expression	R-HSA-212165	1.141653e-01	0.942	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	8.695348e-02	1.061	0	0
mRNA Editing: C to U Conversion	R-HSA-72200	1.257246e-01	0.901	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	1.077633e-01	0.968	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	1.275056e-01	0.894	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	1.275056e-01	0.894	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	1.275056e-01	0.894	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	1.275056e-01	0.894	0	0
Cell-extracellular matrix interactions	R-HSA-446353	1.123174e-01	0.950	0	0
Cardiogenesis	R-HSA-9733709	9.382572e-02	1.028	0	0
Autophagy	R-HSA-9612973	1.200957e-01	0.920	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	9.349488e-02	1.029	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	8.591529e-02	1.066	0	0
Signaling by WNT in cancer	R-HSA-4791275	8.639452e-02	1.064	0	0
Macroautophagy	R-HSA-1632852	1.112555e-01	0.954	0	0
Frs2-mediated activation	R-HSA-170968	8.768203e-02	1.057	0	0
HDMs demethylate histones	R-HSA-3214842	1.244724e-01	0.905	0	0
Mitochondrial biogenesis	R-HSA-1592230	1.119867e-01	0.951	0	0
Prolonged ERK activation events	R-HSA-169893	1.255146e-01	0.901	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	9.539022e-02	1.020	0	0
Formation of editosomes by ADAR proteins	R-HSA-77042	1.151570e-01	0.939	0	0
Inhibition of PKR	R-HSA-169131	1.151570e-01	0.939	0	0
Formation of the Editosome	R-HSA-75094	8.695348e-02	1.061	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	9.493280e-02	1.023	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	1.077633e-01	0.968	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	1.159370e-01	0.936	0	0
Formation of the nephric duct	R-HSA-9830364	1.244724e-01	0.905	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	1.275056e-01	0.894	0	0
Cellular responses to stress	R-HSA-2262752	1.004853e-01	0.998	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.123174e-01	0.950	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	9.493280e-02	1.023	0	0
Toll-like Receptor Cascades	R-HSA-168898	9.981287e-02	1.001	1	0
Transcriptional regulation by RUNX1	R-HSA-8878171	1.257272e-01	0.901	0	0
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	1.257246e-01	0.901	0	0
Signaling by NOTCH3	R-HSA-9012852	9.558130e-02	1.020	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	1.159370e-01	0.936	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	1.244724e-01	0.905	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	1.244724e-01	0.905	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	1.171541e-01	0.931	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	1.171541e-01	0.931	0	0
Synthesis of PIPs in the nucleus	R-HSA-8847453	1.257246e-01	0.901	0	0
Neuronal System	R-HSA-112316	1.128347e-01	0.948	0	0
Integration of energy metabolism	R-HSA-163685	9.236225e-02	1.035	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.058525e-01	0.975	0	0
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	1.123174e-01	0.950	0	0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	1.123174e-01	0.950	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	1.210472e-01	0.917	0	0
MECP2 regulates transcription factors	R-HSA-9022707	1.257246e-01	0.901	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	1.015725e-01	0.993	0	0
Sensory processing of sound	R-HSA-9659379	9.056088e-02	1.043	0	0
Signaling by PDGFR in disease	R-HSA-9671555	8.591529e-02	1.066	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	8.695348e-02	1.061	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	1.257246e-01	0.901	0	0
Gap junction assembly	R-HSA-190861	1.096268e-01	0.960	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.281507e-01	0.892	0	0
Cellular response to heat stress	R-HSA-3371556	1.305110e-01	0.884	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	1.322574e-01	0.879	0	0
MAP kinase activation	R-HSA-450294	1.344652e-01	0.871	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	1.344652e-01	0.871	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	1.350892e-01	0.869	0	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	1.350892e-01	0.869	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	1.350892e-01	0.869	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	1.350892e-01	0.869	0	0
Ovarian tumor domain proteases	R-HSA-5689896	1.355530e-01	0.868	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	1.355530e-01	0.868	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	1.363567e-01	0.865	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	1.363567e-01	0.865	0	0
Signaling by FGFR	R-HSA-190236	1.367140e-01	0.864	0	0
Regulation of insulin secretion	R-HSA-422356	1.367140e-01	0.864	0	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	1.392363e-01	0.856	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	1.392363e-01	0.856	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	1.392363e-01	0.856	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.402698e-01	0.853	0	0
Gap junction trafficking and regulation	R-HSA-157858	1.402698e-01	0.853	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	1.405272e-01	0.852	0	0
Centrosome maturation	R-HSA-380287	1.410019e-01	0.851	0	0
Signaling by PDGF	R-HSA-186797	1.416079e-01	0.849	0	0
Ion channel transport	R-HSA-983712	1.438135e-01	0.842	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	1.447502e-01	0.839	0	0
Diseases of programmed cell death	R-HSA-9645723	1.453281e-01	0.838	0	0
Packaging Of Telomere Ends	R-HSA-171306	1.460591e-01	0.835	0	0
RSK activation	R-HSA-444257	1.463881e-01	0.834	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	1.463881e-01	0.834	0	0
FGFR1b ligand binding and activation	R-HSA-190370	1.463881e-01	0.834	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	1.463881e-01	0.834	0	0
Axonal growth inhibition (RHOA activation)	R-HSA-193634	1.463881e-01	0.834	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.463881e-01	0.834	0	0
Signaling by NOTCH1	R-HSA-1980143	1.476595e-01	0.831	0	0
Cilium Assembly	R-HSA-5617833	1.479532e-01	0.830	0	0
Regulation of RAS by GAPs	R-HSA-5658442	1.484127e-01	0.829	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	1.534353e-01	0.814	0	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	1.534353e-01	0.814	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	1.534353e-01	0.814	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	1.534353e-01	0.814	0	0
RAS processing	R-HSA-9648002	1.542074e-01	0.812	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	1.542074e-01	0.812	0	0
G1/S Transition	R-HSA-69206	1.558897e-01	0.807	0	0
Cell junction organization	R-HSA-446728	1.559326e-01	0.807	0	0
Chromatin organization	R-HSA-4839726	1.568070e-01	0.805	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	1.573615e-01	0.803	0	0
Telomere Extension By Telomerase	R-HSA-171319	1.573615e-01	0.803	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	1.573615e-01	0.803	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	1.573615e-01	0.803	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	1.573615e-01	0.803	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.579361e-01	0.802	0	0
Transmission across Chemical Synapses	R-HSA-112315	1.588377e-01	0.799	0	0
Signaling by Hedgehog	R-HSA-5358351	1.609574e-01	0.793	0	0
Signaling by extracellular domain mutants of KIT	R-HSA-9680187	1.676675e-01	0.776	0	0
Signaling by juxtamembrane domain KIT mutants	R-HSA-9669935	1.676675e-01	0.776	0	0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects	R-HSA-9630750	1.676675e-01	0.776	0	0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects	R-HSA-9632693	1.676675e-01	0.776	0	0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9632700	1.676675e-01	0.776	0	0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	1.676675e-01	0.776	0	0
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	1.676675e-01	0.776	0	0
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	1.676675e-01	0.776	0	0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9630794	1.676675e-01	0.776	0	0
Signaling by kinase domain mutants of KIT	R-HSA-9669933	1.676675e-01	0.776	0	0
DSCAM interactions	R-HSA-376172	2.170648e-01	0.663	0	0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	2.170648e-01	0.663	0	0
Signaling by RAS GAP mutants	R-HSA-9753510	2.170648e-01	0.663	0	0
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	2.170648e-01	0.663	0	0
Potassium transport channels	R-HSA-1296067	2.170648e-01	0.663	0	0
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	2.170648e-01	0.663	0	0
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	2.170648e-01	0.663	0	0
Adrenaline signalling through Alpha-2 adrenergic receptor	R-HSA-392023	2.635332e-01	0.579	0	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	2.635332e-01	0.579	0	0
Classical Kir channels	R-HSA-1296053	2.635332e-01	0.579	0	0
Defective GCLC causes HAGGSD	R-HSA-5578999	2.635332e-01	0.579	0	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	2.635332e-01	0.579	0	0
CASP8 activity is inhibited	R-HSA-5218900	1.676794e-01	0.776	0	0
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	3.072463e-01	0.513	0	0
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate	R-HSA-2978092	3.072463e-01	0.513	0	0
Signaling by MAP2K mutants	R-HSA-9652169	3.072463e-01	0.513	0	0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	3.072463e-01	0.513	0	0
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	3.072463e-01	0.513	0	0
Defective MAT1A causes MATD	R-HSA-5579024	3.072463e-01	0.513	0	0
PI3K/AKT activation	R-HSA-198203	1.894514e-01	0.723	0	0
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	1.894514e-01	0.723	0	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	2.339242e-01	0.631	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	2.339242e-01	0.631	0	0
IRAK1 recruits IKK complex	R-HSA-937039	2.564018e-01	0.591	0	0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	2.564018e-01	0.591	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	1.984297e-01	0.702	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	2.789118e-01	0.555	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	2.140748e-01	0.669	0	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	2.140748e-01	0.669	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	1.689756e-01	0.772	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.689756e-01	0.772	0	0
FRS-mediated FGFR3 signaling	R-HSA-5654706	2.299700e-01	0.638	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	2.299700e-01	0.638	0	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	2.299700e-01	0.638	1	1
Regulation of KIT signaling	R-HSA-1433559	3.013711e-01	0.521	0	0
FRS-mediated FGFR4 signaling	R-HSA-5654712	2.460732e-01	0.609	0	0
Notch-HLH transcription pathway	R-HSA-350054	2.460732e-01	0.609	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	2.439832e-01	0.613	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	2.439832e-01	0.613	0	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	2.952350e-01	0.530	0	0
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	2.490009e-01	0.604	0	0
Voltage gated Potassium channels	R-HSA-1296072	2.839248e-01	0.547	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	2.181133e-01	0.661	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	2.789118e-01	0.555	0	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	2.439832e-01	0.613	0	0
Signal attenuation	R-HSA-74749	1.894514e-01	0.723	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	2.460732e-01	0.609	0	0
CD28 dependent Vav1 pathway	R-HSA-389359	2.789118e-01	0.555	0	0
Germ layer formation at gastrulation	R-HSA-9754189	1.830781e-01	0.737	0	0
Regulation of CDH11 function	R-HSA-9762292	1.894514e-01	0.723	0	0
Insulin receptor signalling cascade	R-HSA-74751	2.805627e-01	0.552	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	1.680647e-01	0.775	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	2.439832e-01	0.613	0	0
Regulation of gap junction activity	R-HSA-191650	3.072463e-01	0.513	0	0
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	3.072463e-01	0.513	0	0
cGMP effects	R-HSA-418457	3.013711e-01	0.521	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	1.767556e-01	0.753	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	2.460732e-01	0.609	0	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	2.564018e-01	0.591	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	3.110662e-01	0.507	0	0
G alpha (z) signalling events	R-HSA-418597	1.920938e-01	0.716	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	1.639129e-01	0.785	0	0
Neurexins and neuroligins	R-HSA-6794361	3.069008e-01	0.513	0	0
TNFR1-mediated ceramide production	R-HSA-5626978	3.072463e-01	0.513	0	0
Formation of the posterior neural plate	R-HSA-9832991	2.115723e-01	0.675	0	0
Sensing of DNA Double Strand Breaks	R-HSA-5693548	2.339242e-01	0.631	0	0
FGFR1c ligand binding and activation	R-HSA-190373	2.789118e-01	0.555	0	0
DCC mediated attractive signaling	R-HSA-418885	3.237066e-01	0.490	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	2.952350e-01	0.530	0	0
Tight junction interactions	R-HSA-420029	2.952350e-01	0.530	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	2.047636e-01	0.689	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	2.060217e-01	0.686	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	3.225365e-01	0.491	0	0
DAP12 signaling	R-HSA-2424491	1.808797e-01	0.743	0	0
Mitotic Prophase	R-HSA-68875	2.033123e-01	0.692	0	0
Interleukin-2 signaling	R-HSA-9020558	2.115723e-01	0.675	0	0
p75NTR regulates axonogenesis	R-HSA-193697	1.676794e-01	0.776	0	0
Resolution of D-Loop Structures	R-HSA-5693537	2.309581e-01	0.636	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	3.117830e-01	0.506	0	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	3.072463e-01	0.513	0	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	3.072463e-01	0.513	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	2.115723e-01	0.675	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	2.789118e-01	0.555	0	0
CRMPs in Sema3A signaling	R-HSA-399956	3.013711e-01	0.521	0	0
Lysosphingolipid and LPA receptors	R-HSA-419408	3.237066e-01	0.490	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	1.752903e-01	0.756	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	2.181133e-01	0.661	0	0
GABA receptor activation	R-HSA-977443	2.399758e-01	0.620	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	2.852302e-01	0.545	0	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	2.339242e-01	0.631	0	0
Repression of WNT target genes	R-HSA-4641265	2.564018e-01	0.591	0	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	2.309581e-01	0.636	0	0
Chromatin modifying enzymes	R-HSA-3247509	2.970758e-01	0.527	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	1.680647e-01	0.775	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	1.840210e-01	0.735	0	0
GPVI-mediated activation cascade	R-HSA-114604	2.704877e-01	0.568	0	0
Interleukin-1 signaling	R-HSA-9020702	2.511741e-01	0.600	1	1
ARL13B-mediated ciliary trafficking of INPP5E	R-HSA-5624958	1.676675e-01	0.776	0	0
Manipulation of host energy metabolism	R-HSA-9636667	1.676675e-01	0.776	0	0
mRNA Editing: A to I Conversion	R-HSA-75064	2.170648e-01	0.663	0	0
C6 deamination of adenosine	R-HSA-75102	2.170648e-01	0.663	0	0
Influenza Virus Induced Apoptosis	R-HSA-168277	2.170648e-01	0.663	0	0
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	2.170648e-01	0.663	0	0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	2.635332e-01	0.579	0	0
ARMS-mediated activation	R-HSA-170984	1.676794e-01	0.776	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	1.676794e-01	0.776	0	0
Ionotropic activity of kainate receptors	R-HSA-451306	2.115723e-01	0.675	0	0
vRNP Assembly	R-HSA-192905	2.115723e-01	0.675	0	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	2.339242e-01	0.631	0	0
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	2.564018e-01	0.591	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	2.789118e-01	0.555	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	2.299700e-01	0.638	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	1.639129e-01	0.785	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	3.237066e-01	0.490	0	0
Metalloprotease DUBs	R-HSA-5689901	3.117830e-01	0.506	0	0
Intraflagellar transport	R-HSA-5620924	2.603706e-01	0.584	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	1.916357e-01	0.718	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	3.049498e-01	0.516	0	0
Opioid Signalling	R-HSA-111885	1.722873e-01	0.764	0	0
MDK and PTN in ALK signaling	R-HSA-9851151	3.072463e-01	0.513	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	1.741424e-01	0.759	0	0
Membrane Trafficking	R-HSA-199991	2.783525e-01	0.555	0	0
Activation of NOXA and translocation to mitochondria	R-HSA-111448	3.072463e-01	0.513	0	0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	3.237066e-01	0.490	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	2.399758e-01	0.620	0	0
Pexophagy	R-HSA-9664873	1.894514e-01	0.723	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	2.299700e-01	0.638	0	0
Metabolism of RNA	R-HSA-8953854	2.736754e-01	0.563	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	2.564018e-01	0.591	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	1.689756e-01	0.772	0	0
Interleukin-17 signaling	R-HSA-448424	2.047636e-01	0.689	0	0
Cell-cell junction organization	R-HSA-421270	2.285593e-01	0.641	0	0
Adherens junctions interactions	R-HSA-418990	2.931620e-01	0.533	0	0
Amine ligand-binding receptors	R-HSA-375280	2.157366e-01	0.666	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	1.639129e-01	0.785	1	0
Diseases of Immune System	R-HSA-5260271	1.639129e-01	0.785	1	0
Platelet homeostasis	R-HSA-418346	1.915647e-01	0.718	0	0
PLC beta mediated events	R-HSA-112043	2.499600e-01	0.602	0	0
Adaptive Immune System	R-HSA-1280218	2.893586e-01	0.539	0	0
Leishmania infection	R-HSA-9658195	2.281920e-01	0.642	0	0
Parasitic Infection Pathways	R-HSA-9824443	2.281920e-01	0.642	0	0
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	2.635332e-01	0.579	0	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	2.339242e-01	0.631	0	0
Reduction of cytosolic Ca++ levels	R-HSA-418359	2.339242e-01	0.631	0	0
Platelet sensitization by LDL	R-HSA-432142	1.680647e-01	0.775	0	0
Maturation of nucleoprotein	R-HSA-9683610	2.789118e-01	0.555	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	1.930520e-01	0.714	0	0
Cell-Cell communication	R-HSA-1500931	2.490651e-01	0.604	0	0
Signaling by GPCR	R-HSA-372790	1.695803e-01	0.771	0	0
RUNX2 regulates bone development	R-HSA-8941326	2.704877e-01	0.568	0	0
ISG15 antiviral mechanism	R-HSA-1169408	2.488061e-01	0.604	0	0
MTOR signalling	R-HSA-165159	1.943987e-01	0.711	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	2.399758e-01	0.620	0	0
Signaling by TGFBR3	R-HSA-9839373	2.377630e-01	0.624	0	0
Interleukin-6 signaling	R-HSA-1059683	2.789118e-01	0.555	0	0
Deubiquitination	R-HSA-5688426	2.478030e-01	0.606	0	0
Ca2+ pathway	R-HSA-4086398	2.308357e-01	0.637	0	0
Reproduction	R-HSA-1474165	2.852437e-01	0.545	0	0
Co-inhibition by PD-1	R-HSA-389948	2.714001e-01	0.566	0	0
Histamine receptors	R-HSA-390650	2.635332e-01	0.579	0	0
Maturation of nucleoprotein	R-HSA-9694631	1.830781e-01	0.737	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	3.237066e-01	0.490	0	0
Regulation of necroptotic cell death	R-HSA-5675482	2.181133e-01	0.661	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	2.181133e-01	0.661	0	0
Signal transduction by L1	R-HSA-445144	1.984297e-01	0.702	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	1.911151e-01	0.719	0	0
Formation of the anterior neural plate	R-HSA-9823739	3.237066e-01	0.490	0	0
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	2.635332e-01	0.579	0	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	1.676794e-01	0.776	0	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	1.894514e-01	0.723	0	0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	2.789118e-01	0.555	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	2.974576e-01	0.527	0	0
Signaling by Erythropoietin	R-HSA-9006335	1.689756e-01	0.772	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	2.140748e-01	0.669	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	2.309581e-01	0.636	0	0
Cleavage of the damaged purine	R-HSA-110331	2.839248e-01	0.547	0	0
Depurination	R-HSA-73927	2.974576e-01	0.527	0	0
Interleukin-1 processing	R-HSA-448706	1.676794e-01	0.776	0	0
Respiratory syncytial virus genome replication	R-HSA-9834752	1.676794e-01	0.776	0	0
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	2.339242e-01	0.631	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	2.054706e-01	0.687	0	0
Kidney development	R-HSA-9830369	3.119453e-01	0.506	0	0
Regulated Necrosis	R-HSA-5218859	3.225365e-01	0.491	0	0
Stimuli-sensing channels	R-HSA-2672351	3.158880e-01	0.500	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	2.600587e-01	0.585	0	0
Acyl chain remodeling of CL	R-HSA-1482798	3.013711e-01	0.521	0	0
ChREBP activates metabolic gene expression	R-HSA-163765	2.115723e-01	0.675	0	0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	2.789118e-01	0.555	0	0
Gap junction trafficking	R-HSA-190828	2.157366e-01	0.666	0	0
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	2.564018e-01	0.591	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	1.644327e-01	0.784	0	0
SARS-CoV-2 Infection	R-HSA-9694516	2.596478e-01	0.586	0	0
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	1.676794e-01	0.776	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	3.069008e-01	0.513	0	0
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	2.789118e-01	0.555	0	0
Replication of the SARS-CoV-1 genome	R-HSA-9682706	2.789118e-01	0.555	0	0
FLT3 Signaling	R-HSA-9607240	1.738549e-01	0.760	0	0
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	3.013711e-01	0.521	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	3.110662e-01	0.507	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	3.013711e-01	0.521	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	2.439832e-01	0.613	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	3.247310e-01	0.488	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	3.247310e-01	0.488	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	3.283543e-01	0.484	0	0
Cristae formation	R-HSA-8949613	3.283543e-01	0.484	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	3.283543e-01	0.484	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	3.283543e-01	0.484	0	0
Potassium Channels	R-HSA-1296071	3.336182e-01	0.477	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	3.339359e-01	0.476	0	0
SARS-CoV Infections	R-HSA-9679506	3.404137e-01	0.468	0	0
FRS-mediated FGFR2 signaling	R-HSA-5654700	3.449174e-01	0.462	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	3.458540e-01	0.461	0	0
Activation of SMO	R-HSA-5635838	3.458540e-01	0.461	0	0
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	3.458540e-01	0.461	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	3.458540e-01	0.461	0	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	3.458540e-01	0.461	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	3.458540e-01	0.461	0	0
IRS activation	R-HSA-74713	3.483673e-01	0.458	0	0
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	3.483673e-01	0.458	0	0
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	3.483673e-01	0.458	0	0
Defective SLC1A3 causes episodic ataxia 6 (EA6)	R-HSA-5619062	3.483673e-01	0.458	0	0
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	3.483673e-01	0.458	0	0
Activation of AKT2	R-HSA-165158	3.483673e-01	0.458	0	0
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	3.483673e-01	0.458	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	3.483673e-01	0.458	0	0
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	3.483673e-01	0.458	0	0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	3.483673e-01	0.458	0	0
SMAC (DIABLO) binds to IAPs	R-HSA-111463	3.483673e-01	0.458	0	0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	3.483673e-01	0.458	0	0
Intra-Golgi traffic	R-HSA-6811438	3.521548e-01	0.453	0	0
HATs acetylate histones	R-HSA-3214847	3.607744e-01	0.443	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	3.614429e-01	0.442	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	3.614429e-01	0.442	0	0
Ca-dependent events	R-HSA-111996	3.658780e-01	0.437	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	3.658780e-01	0.437	0	0
Depyrimidination	R-HSA-73928	3.658780e-01	0.437	0	0
IRS-mediated signalling	R-HSA-112399	3.664582e-01	0.436	0	0
Passive transport by Aquaporins	R-HSA-432047	3.677570e-01	0.434	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	3.677570e-01	0.434	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	3.677570e-01	0.434	0	0
Phase 2 - plateau phase	R-HSA-5576893	3.677570e-01	0.434	0	0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	3.677570e-01	0.434	0	0
Synthesis of PG	R-HSA-1483148	3.677570e-01	0.434	0	0
Glycolysis	R-HSA-70171	3.698798e-01	0.432	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	3.779029e-01	0.423	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	3.779029e-01	0.423	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	3.779029e-01	0.423	0	0
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	3.779029e-01	0.423	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	3.779029e-01	0.423	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	3.779029e-01	0.423	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	3.795860e-01	0.421	0	0
Signaling by ROBO receptors	R-HSA-376176	3.847752e-01	0.415	0	0
Signaling by ERBB4	R-HSA-1236394	3.868247e-01	0.412	0	0
Noncanonical activation of NOTCH3	R-HSA-9017802	3.870497e-01	0.412	0	0
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	3.870497e-01	0.412	0	0
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	3.870497e-01	0.412	0	0
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	3.870497e-01	0.412	0	0
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	3.870497e-01	0.412	0	0
Phosphorylation of Emi1	R-HSA-176417	3.870497e-01	0.412	0	0
Signalling to p38 via RIT and RIN	R-HSA-187706	3.870497e-01	0.412	0	0
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	3.870497e-01	0.412	0	0
CLEC7A/inflammasome pathway	R-HSA-5660668	3.870497e-01	0.412	0	0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	3.870497e-01	0.412	0	0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	3.870497e-01	0.412	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	3.870497e-01	0.412	0	0
TRAIL signaling	R-HSA-75158	3.870497e-01	0.412	0	0
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	3.870497e-01	0.412	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	3.893666e-01	0.410	0	0
Signaling by Hippo	R-HSA-2028269	3.893666e-01	0.410	0	0
Replication of the SARS-CoV-2 genome	R-HSA-9694686	3.893666e-01	0.410	0	0
Interferon alpha/beta signaling	R-HSA-909733	3.921467e-01	0.407	0	0
DAP12 interactions	R-HSA-2172127	3.932627e-01	0.405	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	3.942718e-01	0.404	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	3.942718e-01	0.404	0	0
EGFR downregulation	R-HSA-182971	3.942718e-01	0.404	0	0
Trafficking of AMPA receptors	R-HSA-399719	3.942718e-01	0.404	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	3.975830e-01	0.401	0	0
Innate Immune System	R-HSA-168249	4.066685e-01	0.391	1	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	4.068927e-01	0.391	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	4.068927e-01	0.391	0	0
SARS-CoV-1 Infection	R-HSA-9678108	4.087031e-01	0.389	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	4.105255e-01	0.387	0	0
GAB1 signalosome	R-HSA-180292	4.106406e-01	0.387	0	0
FGFR1 ligand binding and activation	R-HSA-190242	4.106406e-01	0.387	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	4.106406e-01	0.387	0	0
PKA activation in glucagon signalling	R-HSA-164378	4.106406e-01	0.387	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	4.106406e-01	0.387	0	0
PKA activation	R-HSA-163615	4.106406e-01	0.387	0	0
Apoptotic factor-mediated response	R-HSA-111471	4.106406e-01	0.387	0	0
Vitamin D (calciferol) metabolism	R-HSA-196791	4.106406e-01	0.387	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	4.106406e-01	0.387	0	0
Nephron development	R-HSA-9831926	4.106406e-01	0.387	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	4.106406e-01	0.387	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	4.142761e-01	0.383	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	4.142761e-01	0.383	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	4.190639e-01	0.378	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	4.204613e-01	0.376	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	4.204613e-01	0.376	0	0
IRE1alpha activates chaperones	R-HSA-381070	4.223593e-01	0.374	0	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	4.234380e-01	0.373	0	0
NADPH regeneration	R-HSA-389542	4.234380e-01	0.373	0	0
Intracellular metabolism of fatty acids regulates insulin secretion	R-HSA-434313	4.234380e-01	0.373	0	0
Abacavir transmembrane transport	R-HSA-2161517	4.234380e-01	0.373	0	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	4.234380e-01	0.373	0	0
CREB phosphorylation	R-HSA-199920	4.234380e-01	0.373	0	0
VLDL assembly	R-HSA-8866423	4.234380e-01	0.373	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	4.261627e-01	0.370	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	4.266418e-01	0.370	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	4.266418e-01	0.370	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	4.266418e-01	0.370	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	4.266418e-01	0.370	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	4.266418e-01	0.370	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	4.266418e-01	0.370	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	4.276958e-01	0.369	0	0
Specification of the neural plate border	R-HSA-9834899	4.315426e-01	0.365	0	0
Other interleukin signaling	R-HSA-449836	4.315426e-01	0.365	0	0
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	4.315426e-01	0.365	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	4.338378e-01	0.363	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	4.339546e-01	0.363	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	4.404466e-01	0.356	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	4.426002e-01	0.354	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	4.426002e-01	0.354	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	4.426002e-01	0.354	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	4.426002e-01	0.354	0	0
Miscellaneous transport and binding events	R-HSA-5223345	4.426002e-01	0.354	0	0
Chromosome Maintenance	R-HSA-73886	4.435364e-01	0.353	0	0
HCMV Early Events	R-HSA-9609690	4.436923e-01	0.353	0	0
Potential therapeutics for SARS	R-HSA-9679191	4.516705e-01	0.345	0	0
Mitochondrial protein degradation	R-HSA-9837999	4.517520e-01	0.345	0	0
Formation of ATP by chemiosmotic coupling	R-HSA-163210	4.520419e-01	0.345	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	4.520419e-01	0.345	0	0
Protein hydroxylation	R-HSA-9629569	4.520419e-01	0.345	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	4.576682e-01	0.339	0	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	4.576682e-01	0.339	0	0
Disinhibition of SNARE formation	R-HSA-114516	4.576682e-01	0.339	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	4.576682e-01	0.339	0	0
LDL remodeling	R-HSA-8964041	4.576682e-01	0.339	0	0
Ca2+ activated K+ channels	R-HSA-1296052	4.576682e-01	0.339	0	0
Netrin mediated repulsion signals	R-HSA-418886	4.576682e-01	0.339	0	0
Nef Mediated CD4 Down-regulation	R-HSA-167590	4.576682e-01	0.339	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	4.606633e-01	0.337	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	4.606633e-01	0.337	0	0
Degradation of CDH1	R-HSA-9766229	4.606633e-01	0.337	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	4.669725e-01	0.331	0	0
Interleukin-1 family signaling	R-HSA-446652	4.669725e-01	0.331	1	0
Neutrophil degranulation	R-HSA-6798695	4.687141e-01	0.329	0	0
G-protein activation	R-HSA-202040	4.721127e-01	0.326	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	4.721127e-01	0.326	0	0
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	4.721127e-01	0.326	0	0
ERK/MAPK targets	R-HSA-198753	4.721127e-01	0.326	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	4.721127e-01	0.326	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	4.721127e-01	0.326	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	4.739702e-01	0.324	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	4.808440e-01	0.318	0	0
COPI-mediated anterograde transport	R-HSA-6807878	4.808440e-01	0.318	0	0
PTEN Regulation	R-HSA-6807070	4.840118e-01	0.315	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	4.840118e-01	0.315	0	0
Meiotic recombination	R-HSA-912446	4.869222e-01	0.313	0	0
PRC2 methylates histones and DNA	R-HSA-212300	4.893491e-01	0.310	0	0
HSF1 activation	R-HSA-3371511	4.893491e-01	0.310	0	0
FLT3 signaling in disease	R-HSA-9682385	4.893491e-01	0.310	0	0
Calmodulin induced events	R-HSA-111933	4.893491e-01	0.310	0	0
CaM pathway	R-HSA-111997	4.893491e-01	0.310	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	4.898681e-01	0.310	0	0
Regulation by c-FLIP	R-HSA-3371378	4.898681e-01	0.310	0	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	4.898681e-01	0.310	0	0
Dimerization of procaspase-8	R-HSA-69416	4.898681e-01	0.310	0	0
phospho-PLA2 pathway	R-HSA-111995	4.898681e-01	0.310	0	0
Co-stimulation by ICOS	R-HSA-9927354	4.898681e-01	0.310	0	0
Interleukin-9 signaling	R-HSA-8985947	4.898681e-01	0.310	0	0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	4.898681e-01	0.310	0	0
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	4.898681e-01	0.310	0	0
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	4.898681e-01	0.310	0	0
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	4.898681e-01	0.310	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	4.898681e-01	0.310	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	4.898681e-01	0.310	0	0
Downregulation of ERBB4 signaling	R-HSA-1253288	4.898681e-01	0.310	0	0
Activated NTRK2 signals through FYN	R-HSA-9032500	4.898681e-01	0.310	0	0
Interleukin-23 signaling	R-HSA-9020933	4.898681e-01	0.310	0	0
Telomere Maintenance	R-HSA-157579	4.904504e-01	0.309	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	4.919710e-01	0.308	0	0
Leishmania phagocytosis	R-HSA-9664417	4.919710e-01	0.308	0	0
Parasite infection	R-HSA-9664407	4.919710e-01	0.308	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	4.950052e-01	0.305	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	4.998560e-01	0.301	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	4.998560e-01	0.301	0	0
Platelet degranulation	R-HSA-114608	5.027229e-01	0.299	0	0
Protein-protein interactions at synapses	R-HSA-6794362	5.034517e-01	0.298	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	5.034517e-01	0.298	0	0
Interferon Signaling	R-HSA-913531	5.043191e-01	0.297	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	5.045046e-01	0.297	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	5.045046e-01	0.297	0	0
Ub-specific processing proteases	R-HSA-5689880	5.094015e-01	0.293	0	0
Free fatty acid receptors	R-HSA-444209	5.108874e-01	0.292	0	0
mTORC1-mediated signalling	R-HSA-166208	5.108874e-01	0.292	0	0
Regulation of IFNA/IFNB signaling	R-HSA-912694	5.108874e-01	0.292	0	0
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	5.108874e-01	0.292	0	0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	5.108874e-01	0.292	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	5.126465e-01	0.290	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	5.137201e-01	0.289	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	5.201580e-01	0.284	0	0
MAPK1 (ERK2) activation	R-HSA-112411	5.201580e-01	0.284	0	0
MASTL Facilitates Mitotic Progression	R-HSA-2465910	5.201580e-01	0.284	0	0
Unwinding of DNA	R-HSA-176974	5.201580e-01	0.284	0	0
5-Phosphoribose 1-diphosphate biosynthesis	R-HSA-73843	5.201580e-01	0.284	0	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	5.201580e-01	0.284	0	0
Interleukin-21 signaling	R-HSA-9020958	5.201580e-01	0.284	0	0
Cellular response to mitochondrial stress	R-HSA-9840373	5.201580e-01	0.284	0	0
Regulation of signaling by NODAL	R-HSA-1433617	5.201580e-01	0.284	0	0
Regulation of CDH11 gene transcription	R-HSA-9762293	5.201580e-01	0.284	0	0
WNT mediated activation of DVL	R-HSA-201688	5.201580e-01	0.284	0	0
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	5.201580e-01	0.284	0	0
GP1b-IX-V activation signalling	R-HSA-430116	5.201580e-01	0.284	0	0
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	5.201580e-01	0.284	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	5.201580e-01	0.284	0	0
Lipophagy	R-HSA-9613354	5.201580e-01	0.284	0	0
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	5.201580e-01	0.284	0	0
Butyrophilin (BTN) family interactions	R-HSA-8851680	5.201580e-01	0.284	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	5.239071e-01	0.281	0	0
Signaling by NOTCH	R-HSA-157118	5.244242e-01	0.280	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	5.252848e-01	0.280	0	0
Interleukin receptor SHC signaling	R-HSA-912526	5.295603e-01	0.276	0	0
Syndecan interactions	R-HSA-3000170	5.295603e-01	0.276	0	0
Growth hormone receptor signaling	R-HSA-982772	5.295603e-01	0.276	0	0
Hedgehog 'on' state	R-HSA-5632684	5.299807e-01	0.276	0	0
Regulation of mitotic cell cycle	R-HSA-453276	5.299807e-01	0.276	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	5.299807e-01	0.276	0	0
Metabolism of cofactors	R-HSA-8978934	5.299807e-01	0.276	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	5.340966e-01	0.272	0	0
Stabilization of p53	R-HSA-69541	5.340966e-01	0.272	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	5.340966e-01	0.272	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	5.375905e-01	0.270	0	0
PI Metabolism	R-HSA-1483255	5.375905e-01	0.270	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	5.410230e-01	0.267	0	0
Deadenylation of mRNA	R-HSA-429947	5.477419e-01	0.261	0	0
Thromboxane signalling through TP receptor	R-HSA-428930	5.477419e-01	0.261	0	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	5.477419e-01	0.261	0	0
Plasma lipoprotein assembly	R-HSA-8963898	5.477419e-01	0.261	0	0
Interleukin-6 family signaling	R-HSA-6783589	5.477419e-01	0.261	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	5.477419e-01	0.261	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	5.485120e-01	0.261	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	5.485120e-01	0.261	0	0
Interleukin-2 family signaling	R-HSA-451927	5.485120e-01	0.261	0	0
Folding of actin by CCT/TriC	R-HSA-390450	5.486511e-01	0.261	0	0
2-LTR circle formation	R-HSA-164843	5.486511e-01	0.261	0	0
TET1,2,3 and TDG demethylate DNA	R-HSA-5221030	5.486511e-01	0.261	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	5.486511e-01	0.261	0	0
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	5.486511e-01	0.261	0	0
Formation of intermediate mesoderm	R-HSA-9761174	5.486511e-01	0.261	0	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	5.486511e-01	0.261	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	5.486511e-01	0.261	0	0
Interleukin-27 signaling	R-HSA-9020956	5.486511e-01	0.261	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	5.486511e-01	0.261	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	5.486511e-01	0.261	0	0
Tandem pore domain potassium channels	R-HSA-1296346	5.486511e-01	0.261	0	0
Signaling by Leptin	R-HSA-2586552	5.486511e-01	0.261	0	0
Rab regulation of trafficking	R-HSA-9007101	5.494436e-01	0.260	0	0
Glucose metabolism	R-HSA-70326	5.494436e-01	0.260	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	5.500730e-01	0.260	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	5.500730e-01	0.260	0	0
Influenza Infection	R-HSA-168255	5.518626e-01	0.258	0	0
Circadian clock	R-HSA-9909396	5.519429e-01	0.258	0	0
Regulation of CDH1 Function	R-HSA-9764561	5.622086e-01	0.250	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	5.626617e-01	0.250	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	5.626617e-01	0.250	0	0
Signaling by FGFR in disease	R-HSA-1226099	5.627346e-01	0.250	0	0
Signaling by NOTCH4	R-HSA-9013694	5.627346e-01	0.250	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	5.650121e-01	0.248	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	5.650121e-01	0.248	0	0
Acyl chain remodelling of PS	R-HSA-1482801	5.654247e-01	0.248	0	0
TGFBR3 expression	R-HSA-9839394	5.654247e-01	0.248	0	0
Gastrulation	R-HSA-9758941	5.694600e-01	0.245	0	0
RHOBTB3 ATPase cycle	R-HSA-9706019	5.754539e-01	0.240	0	0
Presynaptic depolarization and calcium channel opening	R-HSA-112308	5.754539e-01	0.240	0	0
FGFR2b ligand binding and activation	R-HSA-190377	5.754539e-01	0.240	0	0
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	5.754539e-01	0.240	0	0
Chylomicron assembly	R-HSA-8963888	5.754539e-01	0.240	0	0
Synthesis of PI	R-HSA-1483226	5.754539e-01	0.240	0	0
Bicarbonate transporters	R-HSA-425381	5.754539e-01	0.240	0	0
Cholesterol biosynthesis via desmosterol	R-HSA-6807047	5.754539e-01	0.240	0	0
Transport of RCbl within the body	R-HSA-9758890	5.754539e-01	0.240	0	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	5.754539e-01	0.240	0	0
SARS-CoV-2 modulates autophagy	R-HSA-9754560	5.754539e-01	0.240	0	0
PECAM1 interactions	R-HSA-210990	5.754539e-01	0.240	0	0
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	5.754539e-01	0.240	0	0
Prostanoid ligand receptors	R-HSA-391908	5.754539e-01	0.240	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	5.765383e-01	0.239	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	5.765383e-01	0.239	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	5.826038e-01	0.235	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	5.826038e-01	0.235	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	5.826038e-01	0.235	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	5.839151e-01	0.234	0	0
Extension of Telomeres	R-HSA-180786	5.859318e-01	0.232	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	5.859318e-01	0.232	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	5.901353e-01	0.229	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	5.901353e-01	0.229	0	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	5.901353e-01	0.229	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	5.901353e-01	0.229	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	5.914149e-01	0.228	0	0
Signaling by Insulin receptor	R-HSA-74752	5.925444e-01	0.227	0	0
Translation of Structural Proteins	R-HSA-9694635	5.942950e-01	0.226	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	5.991115e-01	0.222	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	5.992768e-01	0.222	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	5.992768e-01	0.222	0	0
RNA Polymerase I Promoter Opening	R-HSA-73728	5.992768e-01	0.222	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	5.992768e-01	0.222	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	5.992768e-01	0.222	0	0
Maturation of hRSV A proteins	R-HSA-9828806	5.992768e-01	0.222	0	0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	R-HSA-83936	5.992768e-01	0.222	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	6.001041e-01	0.222	0	0
PI3K events in ERBB4 signaling	R-HSA-1250342	6.006666e-01	0.221	0	0
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	6.006666e-01	0.221	0	0
Signaling by activated point mutants of FGFR1	R-HSA-1839122	6.006666e-01	0.221	0	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	6.006666e-01	0.221	0	0
Activation of RAC1	R-HSA-428540	6.006666e-01	0.221	0	0
Integration of provirus	R-HSA-162592	6.006666e-01	0.221	0	0
Cytochrome c-mediated apoptotic response	R-HSA-111461	6.006666e-01	0.221	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	6.019196e-01	0.220	0	0
TBC/RABGAPs	R-HSA-8854214	6.034475e-01	0.219	0	0
RNA Polymerase I Transcription	R-HSA-73864	6.045293e-01	0.219	0	0
Host Interactions of HIV factors	R-HSA-162909	6.075764e-01	0.216	0	0
Aquaporin-mediated transport	R-HSA-445717	6.088900e-01	0.215	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	6.146146e-01	0.211	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	6.154431e-01	0.211	0	0
Pyroptosis	R-HSA-5620971	6.154431e-01	0.211	0	0
RMTs methylate histone arginines	R-HSA-3214858	6.164707e-01	0.210	0	0
Mitochondrial protein import	R-HSA-1268020	6.200716e-01	0.208	0	0
tRNA processing in the nucleus	R-HSA-6784531	6.200716e-01	0.208	0	0
Heme signaling	R-HSA-9707616	6.200716e-01	0.208	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	6.243833e-01	0.205	0	0
Scavenging by Class F Receptors	R-HSA-3000484	6.243833e-01	0.205	0	0
Beta oxidation of myristoyl-CoA to lauroyl-CoA	R-HSA-77285	6.243833e-01	0.205	0	0
Beta oxidation of palmitoyl-CoA to myristoyl-CoA	R-HSA-77305	6.243833e-01	0.205	0	0
Serotonin clearance from the synaptic cleft	R-HSA-380615	6.243833e-01	0.205	0	0
Regulation of IFNG signaling	R-HSA-877312	6.243833e-01	0.205	0	0
Interleukin-35 Signalling	R-HSA-8984722	6.243833e-01	0.205	0	0
Interleukin-15 signaling	R-HSA-8983432	6.243833e-01	0.205	0	0
Trafficking and processing of endosomal TLR	R-HSA-1679131	6.243833e-01	0.205	0	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	6.243833e-01	0.205	0	0
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	6.243833e-01	0.205	0	0
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	6.243833e-01	0.205	0	0
Estrogen biosynthesis	R-HSA-193144	6.243833e-01	0.205	0	0
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	6.243833e-01	0.205	0	0
Signaling by MET	R-HSA-6806834	6.245476e-01	0.204	0	0
HIV Life Cycle	R-HSA-162587	6.276466e-01	0.202	0	0
Nucleosome assembly	R-HSA-774815	6.292013e-01	0.201	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	6.292013e-01	0.201	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	6.292013e-01	0.201	0	0
Fanconi Anemia Pathway	R-HSA-6783310	6.292013e-01	0.201	0	0
DAG and IP3 signaling	R-HSA-1489509	6.292013e-01	0.201	0	0
Disease	R-HSA-1643685	6.300812e-01	0.201	1	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	6.310500e-01	0.200	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	6.311041e-01	0.200	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	6.416370e-01	0.193	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	6.416370e-01	0.193	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	6.437405e-01	0.191	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	6.439459e-01	0.191	0	0
Activation of the pre-replicative complex	R-HSA-68962	6.462627e-01	0.190	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	6.462627e-01	0.190	0	0
Activation of BH3-only proteins	R-HSA-114452	6.462627e-01	0.190	0	0
Interleukin-37 signaling	R-HSA-9008059	6.462627e-01	0.190	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	6.466929e-01	0.189	0	0
FGFR2c ligand binding and activation	R-HSA-190375	6.466929e-01	0.189	0	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	6.466929e-01	0.189	0	0
FGFR4 ligand binding and activation	R-HSA-190322	6.466929e-01	0.189	0	0
Signaling by activated point mutants of FGFR3	R-HSA-1839130	6.466929e-01	0.189	0	0
FGFR3 mutant receptor activation	R-HSA-2033514	6.466929e-01	0.189	0	0
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	6.466929e-01	0.189	0	0
Budding and maturation of HIV virion	R-HSA-162588	6.609235e-01	0.180	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	6.609235e-01	0.180	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	6.609235e-01	0.180	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	6.656173e-01	0.177	0	0
Gluconeogenesis	R-HSA-70263	6.656173e-01	0.177	0	0
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	6.676787e-01	0.175	0	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	6.676787e-01	0.175	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	6.676787e-01	0.175	0	0
FGFR3c ligand binding and activation	R-HSA-190372	6.676787e-01	0.175	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	6.676787e-01	0.175	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	6.676787e-01	0.175	0	0
Hydrolysis of LPC	R-HSA-1483115	6.676787e-01	0.175	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	6.676787e-01	0.175	0	0
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	R-HSA-77350	6.676787e-01	0.175	0	0
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	R-HSA-77310	6.676787e-01	0.175	0	0
Beta oxidation of octanoyl-CoA to hexanoyl-CoA	R-HSA-77348	6.676787e-01	0.175	0	0
Physiological factors	R-HSA-5578768	6.676787e-01	0.175	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	6.676787e-01	0.175	0	0
Malate-aspartate shuttle	R-HSA-9856872	6.676787e-01	0.175	0	0
Ciprofloxacin ADME	R-HSA-9793528	6.676787e-01	0.175	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	6.676787e-01	0.175	0	0
HDL assembly	R-HSA-8963896	6.676787e-01	0.175	0	0
Synthesis of IPs in the nucleus	R-HSA-1855191	6.676787e-01	0.175	0	0
Signal regulatory protein family interactions	R-HSA-391160	6.676787e-01	0.175	0	0
P2Y receptors	R-HSA-417957	6.676787e-01	0.175	0	0
Vesicle-mediated transport	R-HSA-5653656	6.720405e-01	0.173	0	0
Viral Infection Pathways	R-HSA-9824446	6.724849e-01	0.172	0	0
Inwardly rectifying K+ channels	R-HSA-1296065	6.750920e-01	0.171	0	0
HCMV Infection	R-HSA-9609646	6.806509e-01	0.167	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	6.808110e-01	0.167	0	0
RNA Polymerase III Chain Elongation	R-HSA-73780	6.874191e-01	0.163	0	0
G beta:gamma signalling through BTK	R-HSA-8964315	6.874191e-01	0.163	0	0
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	6.874191e-01	0.163	0	0
Translesion synthesis by REV1	R-HSA-110312	6.874191e-01	0.163	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	6.874191e-01	0.163	0	0
FGFR3 ligand binding and activation	R-HSA-190239	6.874191e-01	0.163	0	0
Signaling by Activin	R-HSA-1502540	6.874191e-01	0.163	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	6.874191e-01	0.163	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	6.874191e-01	0.163	0	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	6.874191e-01	0.163	0	0
DNA Damage Reversal	R-HSA-73942	6.874191e-01	0.163	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	6.884067e-01	0.162	0	0
PI3K Cascade	R-HSA-109704	6.884067e-01	0.162	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	6.887750e-01	0.162	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	6.993562e-01	0.155	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	7.019802e-01	0.154	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	7.019802e-01	0.154	0	0
Translesion synthesis by POLI	R-HSA-5656121	7.059881e-01	0.151	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	7.059881e-01	0.151	0	0
Phosphorylation of the APC/C	R-HSA-176412	7.059881e-01	0.151	0	0
Fructose catabolism	R-HSA-70350	7.059881e-01	0.151	0	0
Differentiation of T cells	R-HSA-9945266	7.059881e-01	0.151	0	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	7.059881e-01	0.151	0	0
Regulation of NF-kappa B signaling	R-HSA-9758274	7.059881e-01	0.151	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	7.113196e-01	0.148	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	7.147160e-01	0.146	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	7.147160e-01	0.146	0	0
eNOS activation	R-HSA-203615	7.147160e-01	0.146	0	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	7.147160e-01	0.146	0	0
Signaling by NOTCH2	R-HSA-1980145	7.147160e-01	0.146	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	7.203725e-01	0.142	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	7.203947e-01	0.142	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	7.203947e-01	0.142	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	7.234550e-01	0.141	0	0
Translesion synthesis by POLK	R-HSA-5655862	7.234550e-01	0.141	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	7.234550e-01	0.141	0	0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	7.234550e-01	0.141	1	1
Scavenging by Class B Receptors	R-HSA-3000471	7.234550e-01	0.141	0	0
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	R-HSA-77288	7.234550e-01	0.141	0	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	7.234550e-01	0.141	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	7.234550e-01	0.141	0	0
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	R-HSA-77346	7.234550e-01	0.141	0	0
Disorders of Developmental Biology	R-HSA-9675151	7.234550e-01	0.141	0	0
G alpha (s) signalling events	R-HSA-418555	7.245205e-01	0.140	0	0
PPARA activates gene expression	R-HSA-1989781	7.301787e-01	0.137	0	0
Translation initiation complex formation	R-HSA-72649	7.304438e-01	0.136	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	7.311307e-01	0.136	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	7.319415e-01	0.136	0	0
Gene Silencing by RNA	R-HSA-211000	7.345000e-01	0.134	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	7.388166e-01	0.131	0	0
Triglyceride catabolism	R-HSA-163560	7.388166e-01	0.131	0	0
G1/S-Specific Transcription	R-HSA-69205	7.388166e-01	0.131	0	0
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	7.398852e-01	0.131	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	7.398852e-01	0.131	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	7.398852e-01	0.131	0	0
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	7.398852e-01	0.131	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	7.398852e-01	0.131	0	0
Antigen processing-Cross presentation	R-HSA-1236975	7.416324e-01	0.130	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	7.421380e-01	0.130	0	0
HIV Infection	R-HSA-162906	7.432439e-01	0.129	0	0
Protein ubiquitination	R-HSA-8852135	7.463475e-01	0.127	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	7.463475e-01	0.127	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	7.465642e-01	0.127	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	7.497273e-01	0.125	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	7.497273e-01	0.125	0	0
TNF signaling	R-HSA-75893	7.497273e-01	0.125	0	0
Degradation of DVL	R-HSA-4641258	7.502013e-01	0.125	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	7.553401e-01	0.122	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	7.553401e-01	0.122	0	0
Activated point mutants of FGFR2	R-HSA-2033519	7.553401e-01	0.122	0	0
Mismatch Repair	R-HSA-5358508	7.553401e-01	0.122	0	0
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	7.553401e-01	0.122	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	7.553401e-01	0.122	0	0
Nucleotide-like (purinergic) receptors	R-HSA-418038	7.553401e-01	0.122	0	0
TCR signaling	R-HSA-202403	7.554825e-01	0.122	0	0
Synthesis of PA	R-HSA-1483166	7.589465e-01	0.120	0	0
MET promotes cell motility	R-HSA-8875878	7.611562e-01	0.119	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	7.611562e-01	0.119	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	7.678891e-01	0.115	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	7.678891e-01	0.115	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	7.687823e-01	0.114	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	7.687823e-01	0.114	0	0
FCERI mediated MAPK activation	R-HSA-2871796	7.687823e-01	0.114	0	0
Inositol phosphate metabolism	R-HSA-1483249	7.687823e-01	0.114	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	7.698777e-01	0.114	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	7.698777e-01	0.114	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	7.698777e-01	0.114	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	7.698777e-01	0.114	0	0
Regulation of signaling by CBL	R-HSA-912631	7.698777e-01	0.114	0	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	7.716922e-01	0.113	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	7.716922e-01	0.113	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	7.716922e-01	0.113	0	0
Metabolism of non-coding RNA	R-HSA-194441	7.765594e-01	0.110	0	0
snRNP Assembly	R-HSA-191859	7.765594e-01	0.110	0	0
Triglyceride metabolism	R-HSA-8979227	7.765594e-01	0.110	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	7.818204e-01	0.107	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	7.818204e-01	0.107	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	7.818204e-01	0.107	0	0
HIV Transcription Elongation	R-HSA-167169	7.818204e-01	0.107	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	7.818204e-01	0.107	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	7.818204e-01	0.107	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	7.818204e-01	0.107	0	0
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	7.835523e-01	0.106	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	7.835523e-01	0.106	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	7.835523e-01	0.106	0	0
Signaling by NODAL	R-HSA-1181150	7.835523e-01	0.106	0	0
Acyl chain remodelling of PI	R-HSA-1482922	7.835523e-01	0.106	0	0
Eicosanoid ligand-binding receptors	R-HSA-391903	7.835523e-01	0.106	0	0
tRNA Aminoacylation	R-HSA-379724	7.849617e-01	0.105	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	7.849617e-01	0.105	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	7.854475e-01	0.105	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	7.894202e-01	0.103	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	7.915520e-01	0.102	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	7.915520e-01	0.102	0	0
Maturation of spike protein	R-HSA-9694548	7.915520e-01	0.102	0	0
Formation of paraxial mesoderm	R-HSA-9793380	7.931009e-01	0.101	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	7.931009e-01	0.101	0	0
Post-translational protein phosphorylation	R-HSA-8957275	7.953966e-01	0.099	0	0
FGFR2 ligand binding and activation	R-HSA-190241	7.964151e-01	0.099	0	0
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	7.964151e-01	0.099	0	0
Basigin interactions	R-HSA-210991	7.964151e-01	0.099	0	0
Acyl chain remodelling of PG	R-HSA-1482925	7.964151e-01	0.099	0	0
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	7.964151e-01	0.099	0	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	7.964151e-01	0.099	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	7.964151e-01	0.099	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	8.008984e-01	0.096	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	8.008984e-01	0.096	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	8.008984e-01	0.096	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	8.008984e-01	0.096	0	0
Translation of Structural Proteins	R-HSA-9683701	8.008984e-01	0.096	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	8.009817e-01	0.096	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	8.085142e-01	0.092	0	0
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	8.085142e-01	0.092	0	0
Eicosanoids	R-HSA-211979	8.085142e-01	0.092	0	0
Miscellaneous substrates	R-HSA-211958	8.085142e-01	0.092	0	0
Glutathione synthesis and recycling	R-HSA-174403	8.085142e-01	0.092	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	8.085142e-01	0.092	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	8.086092e-01	0.092	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	8.098709e-01	0.092	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	8.131413e-01	0.090	0	0
Defective pyroptosis	R-HSA-9710421	8.184810e-01	0.087	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	8.184810e-01	0.087	0	0
Protein localization	R-HSA-9609507	8.198196e-01	0.086	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	8.198950e-01	0.086	0	0
FGFR2 alternative splicing	R-HSA-6803529	8.198950e-01	0.086	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	8.198950e-01	0.086	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	8.198950e-01	0.086	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	8.198950e-01	0.086	0	0
WNT ligand biogenesis and trafficking	R-HSA-3238698	8.198950e-01	0.086	0	0
RAF-independent MAPK1/3 activation	R-HSA-112409	8.198950e-01	0.086	0	0
Fructose metabolism	R-HSA-5652084	8.198950e-01	0.086	0	0
Ethanol oxidation	R-HSA-71384	8.198950e-01	0.086	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	8.198950e-01	0.086	0	0
G alpha (i) signalling events	R-HSA-418594	8.221785e-01	0.085	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	8.267401e-01	0.083	0	0
Surfactant metabolism	R-HSA-5683826	8.267401e-01	0.083	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	8.291668e-01	0.081	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	8.306000e-01	0.081	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	8.306000e-01	0.081	0	0
Fatty acids	R-HSA-211935	8.306000e-01	0.081	0	0
Interleukin-20 family signaling	R-HSA-8854691	8.306000e-01	0.081	0	0
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	8.306000e-01	0.081	0	0
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	8.306000e-01	0.081	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	8.306000e-01	0.081	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	8.311002e-01	0.080	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	8.346594e-01	0.078	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	8.346594e-01	0.078	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	8.406693e-01	0.075	0	0
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	8.406693e-01	0.075	0	0
Complex III assembly	R-HSA-9865881	8.406693e-01	0.075	0	0
Nucleotide Excision Repair	R-HSA-5696398	8.418127e-01	0.075	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	8.422501e-01	0.075	0	0
ER-Phagosome pathway	R-HSA-1236974	8.491247e-01	0.071	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	8.501406e-01	0.071	0	0
G protein gated Potassium channels	R-HSA-1296059	8.501406e-01	0.071	0	0
Activation of G protein gated Potassium channels	R-HSA-1296041	8.501406e-01	0.071	0	0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	8.501406e-01	0.071	0	0
MicroRNA (miRNA) biogenesis	R-HSA-203927	8.501406e-01	0.071	0	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	8.501406e-01	0.071	0	0
Interleukin-7 signaling	R-HSA-1266695	8.501406e-01	0.071	0	0
Downstream TCR signaling	R-HSA-202424	8.545146e-01	0.068	0	0
Base Excision Repair	R-HSA-73884	8.545146e-01	0.068	0	0
NGF-stimulated transcription	R-HSA-9031628	8.564898e-01	0.067	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	8.568272e-01	0.067	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	8.568272e-01	0.067	0	0
MET activates PTK2 signaling	R-HSA-8874081	8.590495e-01	0.066	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	8.590495e-01	0.066	0	0
Abacavir ADME	R-HSA-2161522	8.590495e-01	0.066	0	0
Suppression of phagosomal maturation	R-HSA-9637687	8.590495e-01	0.066	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	8.648045e-01	0.063	0	0
Phospholipid metabolism	R-HSA-1483257	8.660184e-01	0.062	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	8.667324e-01	0.062	0	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	8.667324e-01	0.062	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	8.674293e-01	0.062	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	8.674293e-01	0.062	0	0
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	8.674293e-01	0.062	0	0
Triglyceride biosynthesis	R-HSA-75109	8.674293e-01	0.062	0	0
Insulin processing	R-HSA-264876	8.674293e-01	0.062	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	8.674293e-01	0.062	0	0
HIV elongation arrest and recovery	R-HSA-167287	8.753113e-01	0.058	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	8.753113e-01	0.058	0	0
Formation of the Early Elongation Complex	R-HSA-113418	8.753113e-01	0.058	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	8.753113e-01	0.058	0	0
Pyrimidine salvage	R-HSA-73614	8.753113e-01	0.058	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	8.791980e-01	0.056	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	8.815018e-01	0.055	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	8.815018e-01	0.055	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	8.823239e-01	0.054	0	0
DNA methylation	R-HSA-5334118	8.827252e-01	0.054	0	0
Late endosomal microautophagy	R-HSA-9615710	8.827252e-01	0.054	0	0
mRNA Capping	R-HSA-72086	8.827252e-01	0.054	0	0
Thyroxine biosynthesis	R-HSA-209968	8.827252e-01	0.054	0	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	8.827252e-01	0.054	0	0
DARPP-32 events	R-HSA-180024	8.827252e-01	0.054	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	8.870923e-01	0.052	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	8.870923e-01	0.052	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	8.870923e-01	0.052	0	0
Smooth Muscle Contraction	R-HSA-445355	8.870923e-01	0.052	0	0
UCH proteinases	R-HSA-5689603	8.871481e-01	0.052	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	8.872751e-01	0.052	0	0
Eukaryotic Translation Termination	R-HSA-72764	8.878337e-01	0.052	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	8.896987e-01	0.051	0	0
Neurotransmitter clearance	R-HSA-112311	8.896987e-01	0.051	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.962579e-01	0.048	0	0
Molecules associated with elastic fibres	R-HSA-2129379	8.962579e-01	0.048	0	0
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	8.962579e-01	0.048	0	0
Cholesterol biosynthesis	R-HSA-191273	8.962694e-01	0.048	0	0
HDACs deacetylate histones	R-HSA-3214815	8.975466e-01	0.047	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	8.975466e-01	0.047	0	0
Eukaryotic Translation Initiation	R-HSA-72613	8.985194e-01	0.046	0	0
Cap-dependent Translation Initiation	R-HSA-72737	8.985194e-01	0.046	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.000960e-01	0.046	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.000960e-01	0.046	0	0
Peptide hormone metabolism	R-HSA-2980736	9.020452e-01	0.045	0	0
HS-GAG degradation	R-HSA-2024096	9.024274e-01	0.045	0	0
DNA strand elongation	R-HSA-69190	9.024274e-01	0.045	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	9.024290e-01	0.045	0	0
Nuclear RNA decay	R-HSA-9930044	9.082304e-01	0.042	0	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	9.082304e-01	0.042	0	0
Amyloid fiber formation	R-HSA-977225	9.087109e-01	0.042	0	0
Selenocysteine synthesis	R-HSA-2408557	9.108836e-01	0.041	0	0
Dual incision in TC-NER	R-HSA-6782135	9.115485e-01	0.040	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.115485e-01	0.040	0	0
Acyl chain remodelling of PC	R-HSA-1482788	9.136885e-01	0.039	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.136885e-01	0.039	0	0
Heme degradation	R-HSA-189483	9.136885e-01	0.039	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	9.136885e-01	0.039	0	0
Peroxisomal protein import	R-HSA-9033241	9.158028e-01	0.038	0	0
Infectious disease	R-HSA-5663205	9.161278e-01	0.038	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	9.188224e-01	0.037	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	9.188224e-01	0.037	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	9.188224e-01	0.037	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	9.188224e-01	0.037	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	9.198642e-01	0.036	0	0
RAB geranylgeranylation	R-HSA-8873719	9.198642e-01	0.036	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	9.207474e-01	0.036	0	0
Regulation of Apoptosis	R-HSA-169911	9.236512e-01	0.034	0	0
PERK regulates gene expression	R-HSA-381042	9.236512e-01	0.034	0	0
Acyl chain remodelling of PE	R-HSA-1482839	9.236512e-01	0.034	0	0
Metabolism of ingested SeMet, Sec, MeSec into H2Se	R-HSA-2408508	9.236512e-01	0.034	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	9.236512e-01	0.034	0	0
Nucleotide salvage	R-HSA-8956321	9.237408e-01	0.034	0	0
RSV-host interactions	R-HSA-9833110	9.238111e-01	0.034	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	9.274401e-01	0.033	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	9.279367e-01	0.032	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	9.281930e-01	0.032	0	0
RNA Polymerase III Transcription	R-HSA-74158	9.281930e-01	0.032	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	9.281930e-01	0.032	0	0
Glycosphingolipid transport	R-HSA-9845576	9.281930e-01	0.032	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	9.303833e-01	0.031	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	9.324649e-01	0.030	0	0
Ubiquinol biosynthesis	R-HSA-2142789	9.324649e-01	0.030	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	9.324649e-01	0.030	0	0
SLC-mediated transport of organic cations	R-HSA-549127	9.324649e-01	0.030	0	0
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.324649e-01	0.030	0	0
Pyruvate metabolism	R-HSA-70268	9.326406e-01	0.030	0	0
SLC transporter disorders	R-HSA-5619102	9.345652e-01	0.029	0	0
Peptide chain elongation	R-HSA-156902	9.355439e-01	0.029	0	0
Purine salvage	R-HSA-74217	9.364829e-01	0.029	0	0
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.364829e-01	0.029	0	0
Elastic fibre formation	R-HSA-1566948	9.364829e-01	0.029	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	9.364829e-01	0.029	0	0
Cellular response to hypoxia	R-HSA-1234174	9.375465e-01	0.028	0	0
Pentose phosphate pathway	R-HSA-71336	9.402621e-01	0.027	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.406078e-01	0.027	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.427150e-01	0.026	0	0
Nicotinate metabolism	R-HSA-196807	9.435261e-01	0.025	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	9.435745e-01	0.025	0	0
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.438166e-01	0.025	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	9.438166e-01	0.025	0	0
Generation of second messenger molecules	R-HSA-202433	9.438166e-01	0.025	0	0
Transcription of the HIV genome	R-HSA-167172	9.463077e-01	0.024	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.463077e-01	0.024	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.471598e-01	0.024	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	9.471598e-01	0.024	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	9.471598e-01	0.024	0	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.471598e-01	0.024	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	9.474522e-01	0.023	0	0
Eukaryotic Translation Elongation	R-HSA-156842	9.484015e-01	0.023	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	9.503043e-01	0.022	0	0
HIV Transcription Initiation	R-HSA-167161	9.503043e-01	0.022	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	9.503043e-01	0.022	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	9.503043e-01	0.022	0	0
Scavenging by Class A Receptors	R-HSA-3000480	9.503043e-01	0.022	0	0
Heme biosynthesis	R-HSA-189451	9.503043e-01	0.022	0	0
Assembly of the pre-replicative complex	R-HSA-68867	9.506682e-01	0.022	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	9.514841e-01	0.022	0	0
ECM proteoglycans	R-HSA-3000178	9.538902e-01	0.021	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	9.549256e-01	0.020	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	9.560435e-01	0.020	0	0
HCMV Late Events	R-HSA-9610379	9.561123e-01	0.019	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	9.569230e-01	0.019	0	0
Switching of origins to a post-replicative state	R-HSA-69052	9.583643e-01	0.018	0	0
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.586598e-01	0.018	0	0
Methylation	R-HSA-156581	9.586598e-01	0.018	0	0
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.586598e-01	0.018	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	9.599059e-01	0.018	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	9.604424e-01	0.018	0	0
Transport of vitamins, nucleosides, and related molecules	R-HSA-425397	9.604424e-01	0.018	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.604424e-01	0.018	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.611205e-01	0.017	0	0
mitochondrial fatty acid beta-oxidation of saturated fatty acids	R-HSA-77286	9.611205e-01	0.017	0	0
Somitogenesis	R-HSA-9824272	9.611205e-01	0.017	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.612186e-01	0.017	0	0
Citric acid cycle (TCA cycle)	R-HSA-71403	9.624207e-01	0.017	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	9.634349e-01	0.016	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.634349e-01	0.016	0	0
Regulation of pyruvate metabolism	R-HSA-9861718	9.634349e-01	0.016	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	9.656117e-01	0.015	0	0
Synthesis of PC	R-HSA-1483191	9.656117e-01	0.015	0	0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.656117e-01	0.015	0	0
Selenoamino acid metabolism	R-HSA-2408522	9.660705e-01	0.015	0	0
Plasma lipoprotein remodeling	R-HSA-8963899	9.676590e-01	0.014	0	0
PCP/CE pathway	R-HSA-4086400	9.678018e-01	0.014	0	0
Integrin cell surface interactions	R-HSA-216083	9.678018e-01	0.014	0	0
Regulation of endogenous retroelements	R-HSA-9842860	9.687458e-01	0.014	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.692733e-01	0.014	0	0
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.694246e-01	0.013	0	0
DNA Damage Bypass	R-HSA-73893	9.695845e-01	0.013	0	0
Viral mRNA Translation	R-HSA-192823	9.701604e-01	0.013	0	0
Azathioprine ADME	R-HSA-9748787	9.713955e-01	0.013	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	9.730987e-01	0.012	0	0
The phototransduction cascade	R-HSA-2514856	9.730987e-01	0.012	0	0
tRNA processing	R-HSA-72306	9.739201e-01	0.011	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	9.747007e-01	0.011	0	0
Orc1 removal from chromatin	R-HSA-68949	9.747007e-01	0.011	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.747007e-01	0.011	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	9.747007e-01	0.011	0	0
Cytoprotection by HMOX1	R-HSA-9707564	9.751619e-01	0.011	0	0
Nucleotide biosynthesis	R-HSA-8956320	9.762073e-01	0.010	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.763696e-01	0.010	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	9.776243e-01	0.010	0	0
DNA Replication Pre-Initiation	R-HSA-69002	9.784916e-01	0.009	0	0
Paracetamol ADME	R-HSA-9753281	9.789570e-01	0.009	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.798519e-01	0.009	0	0
Metabolism of amine-derived hormones	R-HSA-209776	9.802104e-01	0.009	0	0
Interferon gamma signaling	R-HSA-877300	9.834556e-01	0.007	0	0
Heparan sulfate/heparin (HS-GAG) metabolism	R-HSA-1638091	9.835405e-01	0.007	0	0
Neurotransmitter release cycle	R-HSA-112310	9.836784e-01	0.007	0	0
Glutathione conjugation	R-HSA-156590	9.845211e-01	0.007	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	9.845766e-01	0.007	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.852981e-01	0.006	0	0
Endogenous sterols	R-HSA-211976	9.854434e-01	0.006	0	0
Collagen degradation	R-HSA-1442490	9.854434e-01	0.006	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.860749e-01	0.006	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.866712e-01	0.006	0	0
Collagen formation	R-HSA-1474290	9.874785e-01	0.005	0	0
Xenobiotics	R-HSA-211981	9.878936e-01	0.005	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	9.886694e-01	0.005	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.887439e-01	0.005	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.893289e-01	0.005	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	9.899318e-01	0.004	0	0
Metabolism of steroid hormones	R-HSA-196071	9.899318e-01	0.004	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	9.904215e-01	0.004	0	0
Formation of the cornified envelope	R-HSA-6809371	9.904865e-01	0.004	0	0
COPII-mediated vesicle transport	R-HSA-204005	9.916271e-01	0.004	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.916271e-01	0.004	0	0
Glycosphingolipid catabolism	R-HSA-9840310	9.916271e-01	0.004	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.917843e-01	0.004	0	0
Metabolism of porphyrins	R-HSA-189445	9.921263e-01	0.003	0	0
Retinoid metabolism and transport	R-HSA-975634	9.921263e-01	0.003	0	0
Iron uptake and transport	R-HSA-917937	9.938428e-01	0.003	0	0
Metabolism of steroids	R-HSA-8957322	9.942896e-01	0.002	0	0
Cellular response to starvation	R-HSA-9711097	9.943228e-01	0.002	0	0
Synthesis of DNA	R-HSA-69239	9.944048e-01	0.002	0	0
rRNA processing	R-HSA-72312	9.944170e-01	0.002	0	0
SLC-mediated transport of organic anions	R-HSA-9955298	9.948800e-01	0.002	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	9.949826e-01	0.002	0	0
Antimicrobial peptides	R-HSA-6803157	9.954970e-01	0.002	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.957427e-01	0.002	0	0
Ribosome-associated quality control	R-HSA-9948299	9.958947e-01	0.002	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.962355e-01	0.002	0	0
Peroxisomal lipid metabolism	R-HSA-390918	9.964601e-01	0.002	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.967542e-01	0.001	0	0
Disorders of transmembrane transporters	R-HSA-5619115	9.969594e-01	0.001	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	9.970567e-01	0.001	0	0
Sulfur amino acid metabolism	R-HSA-1614635	9.970567e-01	0.001	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.976647e-01	0.001	0	0
Class B/2 (Secretin family receptors)	R-HSA-373080	9.976990e-01	0.001	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.978710e-01	0.001	0	0
DNA Replication	R-HSA-69306	9.981731e-01	0.001	0	0
FCGR activation	R-HSA-2029481	9.982012e-01	0.001	0	0
Metabolism of nucleotides	R-HSA-15869	9.983420e-01	0.001	0	0
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.984096e-01	0.001	0	0
Mitochondrial translation elongation	R-HSA-5389840	9.985938e-01	0.001	0	0
Mitochondrial translation initiation	R-HSA-5368286	9.987568e-01	0.001	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.988310e-01	0.001	0	0
Neddylation	R-HSA-8951664	9.990213e-01	0.000	0	0
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.990863e-01	0.000	0	0
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.991922e-01	0.000	0	0
Extracellular matrix organization	R-HSA-1474244	9.992596e-01	0.000	0	0
Post-translational protein modification	R-HSA-597592	9.992694e-01	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	9.993093e-01	0.000	0	0
Mitochondrial translation termination	R-HSA-5419276	9.994064e-01	0.000	0	0
Bile acid and bile salt metabolism	R-HSA-194068	9.994419e-01	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.995083e-01	0.000	0	0
Visual phototransduction	R-HSA-2187338	9.995602e-01	0.000	0	0
Transport of small molecules	R-HSA-382551	9.995913e-01	0.000	0	0
Arachidonate metabolism	R-HSA-2142753	9.996681e-01	0.000	0	0
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.997787e-01	0.000	0	0
Glycosphingolipid metabolism	R-HSA-1660662	9.997787e-01	0.000	0	0
Regulation of Complement cascade	R-HSA-977606	9.998044e-01	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	9.998122e-01	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	9.998243e-01	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.998461e-01	0.000	0	0
Cytochrome P450 - arranged by substrate type	R-HSA-211897	9.998581e-01	0.000	0	0
Sensory perception of taste	R-HSA-9717189	9.998806e-01	0.000	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.998878e-01	0.000	0	0
Keratinization	R-HSA-6805567	9.998982e-01	0.000	0	0
Mitochondrial translation	R-HSA-5368287	9.999271e-01	0.000	0	0
Respiratory electron transport	R-HSA-611105	9.999284e-01	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	9.999547e-01	0.000	0	0
Complement cascade	R-HSA-166658	9.999556e-01	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	9.999569e-01	0.000	0	0
Translation	R-HSA-72766	9.999664e-01	0.000	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999665e-01	0.000	0	0
GPCR ligand binding	R-HSA-500792	9.999775e-01	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	9.999872e-01	0.000	0	0
Drug ADME	R-HSA-9748784	9.999933e-01	0.000	0	0
Asparagine N-linked glycosylation	R-HSA-446203	9.999961e-01	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999964e-01	0.000	0	0
Metabolism of proteins	R-HSA-392499	9.999966e-01	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	9.999979e-01	0.000	0	0
Phase II - Conjugation of compounds	R-HSA-156580	9.999980e-01	0.000	0	0
Fatty acid metabolism	R-HSA-8978868	9.999999e-01	0.000	0	0
Biological oxidations	R-HSA-211859	1.000000e+00	0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000	0	0
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000	0	0
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0
IRAK4 deficiency (TLR5)	R-HSA-5603037	1.000000e+00	0.000	1	1

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p	ref_path	ref_path_lowest
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	1.110223e-16	15.955	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	1.110223e-16	15.955	0	0
Eukaryotic Translation Initiation	R-HSA-72613	1.110223e-16	15.955	0	0
Cap-dependent Translation Initiation	R-HSA-72737	1.110223e-16	15.955	0	0
M Phase	R-HSA-68886	1.110223e-16	15.955	0	0
Cell Cycle, Mitotic	R-HSA-69278	1.110223e-16	15.955	0	0
Cell Cycle	R-HSA-1640170	1.110223e-16	15.955	0	0
Axon guidance	R-HSA-422475	1.110223e-16	15.955	0	0
Nervous system development	R-HSA-9675108	1.110223e-16	15.955	0	0
Cellular responses to stress	R-HSA-2262752	1.110223e-16	15.955	0	0
Metabolism of RNA	R-HSA-8953854	1.110223e-16	15.955	0	0
Cell Cycle Checkpoints	R-HSA-69620	1.110223e-16	15.955	0	0
Cellular responses to stimuli	R-HSA-8953897	1.110223e-16	15.955	0	0
Eukaryotic Translation Elongation	R-HSA-156842	4.440892e-16	15.353	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	1.221245e-15	14.913	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	1.998401e-15	14.699	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	1.998401e-15	14.699	0	0
Peptide chain elongation	R-HSA-156902	4.773959e-15	14.321	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	5.884182e-15	14.230	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	4.296563e-14	13.367	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	5.584422e-14	13.253	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	5.673240e-14	13.246	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	5.673240e-14	13.246	0	0
Signaling by ROBO receptors	R-HSA-376176	6.217249e-14	13.206	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	8.137935e-14	13.089	0	0
Separation of Sister Chromatids	R-HSA-2467813	9.114931e-14	13.040	0	0
Influenza Infection	R-HSA-168255	1.548761e-13	12.810	0	0
Mitotic Anaphase	R-HSA-68882	1.599831e-13	12.796	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.966205e-13	12.706	0	0
Ribosome-associated quality control	R-HSA-9948299	2.661205e-13	12.575	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	2.774447e-13	12.557	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	4.017897e-13	12.396	0	0
Eukaryotic Translation Termination	R-HSA-72764	4.215517e-13	12.375	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	5.340173e-13	12.272	0	0
Translation initiation complex formation	R-HSA-72649	6.252776e-13	12.204	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	7.782663e-13	12.109	0	0
Mitotic Prometaphase	R-HSA-68877	1.187717e-12	11.925	0	0
Cellular response to heat stress	R-HSA-3371556	1.373790e-12	11.862	0	0
Estrogen-dependent gene expression	R-HSA-9018519	1.546763e-12	11.811	0	0
Signal Transduction	R-HSA-162582	2.927769e-12	11.533	1	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	4.419798e-12	11.355	0	0
Cell-Cell communication	R-HSA-1500931	4.707013e-12	11.327	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	4.655720e-12	11.332	0	0
Viral mRNA Translation	R-HSA-192823	4.946377e-12	11.306	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	6.673329e-12	11.176	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	7.117862e-12	11.148	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	7.275514e-12	11.138	0	0
G2/M Checkpoints	R-HSA-69481	8.659407e-12	11.063	0	0
rRNA processing	R-HSA-72312	9.249490e-12	11.034	0	0
Selenocysteine synthesis	R-HSA-2408557	9.391155e-12	11.027	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.497047e-11	10.825	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	3.523837e-11	10.453	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	6.873491e-11	10.163	0	0
Cellular response to starvation	R-HSA-9711097	1.066038e-10	9.972	0	0
Viral Infection Pathways	R-HSA-9824446	1.062550e-10	9.974	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	1.597856e-10	9.796	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	1.776361e-10	9.750	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	2.003103e-10	9.698	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	2.866588e-10	9.543	0	0
Mitotic Prophase	R-HSA-68875	3.072201e-10	9.513	0	0
ESR-mediated signaling	R-HSA-8939211	3.136004e-10	9.504	0	0
HDACs deacetylate histones	R-HSA-3214815	3.425027e-10	9.465	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	3.684765e-10	9.434	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	5.256251e-10	9.279	0	0
RNA Polymerase I Promoter Opening	R-HSA-73728	5.823588e-10	9.235	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	7.459967e-10	9.127	0	0
Assembly of the pre-replicative complex	R-HSA-68867	9.876625e-10	9.005	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.059224e-09	8.975	0	0
DNA Replication Pre-Initiation	R-HSA-69002	1.061658e-09	8.974	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	1.238186e-09	8.907	0	0
HSF1-dependent transactivation	R-HSA-3371571	1.280118e-09	8.893	0	0
Meiotic recombination	R-HSA-912446	1.280118e-09	8.893	0	0
Cell junction organization	R-HSA-446728	1.273713e-09	8.895	0	0
DNA Double Strand Break Response	R-HSA-5693606	1.464622e-09	8.834	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	1.664801e-09	8.779	0	0
DNA methylation	R-HSA-5334118	1.679472e-09	8.775	0	0
Interleukin-12 signaling	R-HSA-9020591	1.878617e-09	8.726	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	1.959019e-09	8.708	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	2.232220e-09	8.651	0	0
Nucleosome assembly	R-HSA-774815	2.232220e-09	8.651	0	0
Meiosis	R-HSA-1500620	2.204685e-09	8.657	0	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	2.363629e-09	8.626	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	2.393020e-09	8.621	0	0
Apoptotic execution phase	R-HSA-75153	3.284983e-09	8.483	0	0
Cellular Senescence	R-HSA-2559583	3.459615e-09	8.461	0	0
G2/M DNA damage checkpoint	R-HSA-69473	3.575581e-09	8.447	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	3.740696e-09	8.427	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	4.108243e-09	8.386	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	5.899786e-09	8.229	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	6.052811e-09	8.218	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	6.052811e-09	8.218	0	0
Diseases of programmed cell death	R-HSA-9645723	6.503419e-09	8.187	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	6.922019e-09	8.160	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	7.509823e-09	8.124	0	0
SARS-CoV-1 Infection	R-HSA-9678108	8.600599e-09	8.065	0	0
Amplification of signal from the kinetochores	R-HSA-141424	9.356560e-09	8.029	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	9.356560e-09	8.029	0	0
Meiotic synapsis	R-HSA-1221632	1.029865e-08	7.987	0	0
Apoptosis	R-HSA-109581	1.070152e-08	7.971	0	0
Developmental Biology	R-HSA-1266738	1.539586e-08	7.813	0	0
Interleukin-12 family signaling	R-HSA-447115	1.573728e-08	7.803	0	0
Recycling pathway of L1	R-HSA-437239	1.917550e-08	7.717	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	2.023982e-08	7.694	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	2.103229e-08	7.677	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	2.236039e-08	7.651	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	2.455719e-08	7.610	0	0
Homology Directed Repair	R-HSA-5693538	3.586398e-08	7.445	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	4.884358e-08	7.311	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	4.948283e-08	7.306	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	5.259824e-08	7.279	0	0
Muscle contraction	R-HSA-397014	5.638444e-08	7.249	0	0
PRC2 methylates histones and DNA	R-HSA-212300	6.077077e-08	7.216	0	0
Aggrephagy	R-HSA-9646399	6.737707e-08	7.171	0	0
Attenuation phase	R-HSA-3371568	6.737707e-08	7.171	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	6.796045e-08	7.168	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	7.659460e-08	7.116	0	0
DNA Replication	R-HSA-69306	7.922205e-08	7.101	0	0
Packaging Of Telomere Ends	R-HSA-171306	8.058642e-08	7.094	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	9.722231e-08	7.012	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	9.785626e-08	7.009	0	0
Regulation of endogenous retroelements	R-HSA-9842860	9.993521e-08	7.000	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	9.993521e-08	7.000	0	0
RNA Polymerase I Transcription	R-HSA-73864	1.138332e-07	6.944	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.286933e-07	6.890	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	1.408253e-07	6.851	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	1.529374e-07	6.815	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	1.529374e-07	6.815	0	0
Selective autophagy	R-HSA-9663891	1.819545e-07	6.740	0	0
EPH-Ephrin signaling	R-HSA-2682334	1.975611e-07	6.704	0	0
Selenoamino acid metabolism	R-HSA-2408522	2.089917e-07	6.680	0	0
Deubiquitination	R-HSA-5688426	2.198047e-07	6.658	0	0
Programmed Cell Death	R-HSA-5357801	2.158198e-07	6.666	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	2.312265e-07	6.636	1	0
SARS-CoV-2-host interactions	R-HSA-9705683	2.484589e-07	6.605	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	2.689958e-07	6.570	0	0
Adherens junctions interactions	R-HSA-418990	2.868333e-07	6.542	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	3.035108e-07	6.518	0	0
Striated Muscle Contraction	R-HSA-390522	3.377107e-07	6.471	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	3.801799e-07	6.420	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	4.443439e-07	6.352	0	0
DNA Repair	R-HSA-73894	4.579997e-07	6.339	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	5.259782e-07	6.279	0	0
Cell-cell junction organization	R-HSA-421270	5.504938e-07	6.259	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	5.578362e-07	6.253	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	5.696196e-07	6.244	0	0
G2/M Transition	R-HSA-69275	6.045054e-07	6.219	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	7.034609e-07	6.153	0	0
Mitotic G2-G2/M phases	R-HSA-453274	8.041221e-07	6.095	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	8.276608e-07	6.082	0	0
Gene Silencing by RNA	R-HSA-211000	9.153039e-07	6.038	0	0
HSF1 activation	R-HSA-3371511	1.010662e-06	5.995	0	0
Defective pyroptosis	R-HSA-9710421	1.015287e-06	5.993	0	0
HATs acetylate histones	R-HSA-3214847	1.074209e-06	5.969	0	0
Chromatin modifying enzymes	R-HSA-3247509	1.115023e-06	5.953	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	1.231097e-06	5.910	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	1.194547e-06	5.923	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	1.419707e-06	5.848	0	0
Cleavage of the damaged purine	R-HSA-110331	1.424377e-06	5.846	0	0
Smooth Muscle Contraction	R-HSA-445355	1.627760e-06	5.788	0	0
Autophagy	R-HSA-9612973	1.632874e-06	5.787	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.729500e-06	5.762	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	1.961040e-06	5.708	0	0
Depurination	R-HSA-73927	1.986897e-06	5.702	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	1.990802e-06	5.701	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	2.064743e-06	5.685	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	2.138463e-06	5.670	0	0
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	2.175826e-06	5.662	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	2.516526e-06	5.599	0	0
Signaling by RAS mutants	R-HSA-6802949	2.513146e-06	5.600	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	2.513146e-06	5.600	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	2.513146e-06	5.600	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	2.513146e-06	5.600	0	0
Chromosome Maintenance	R-HSA-73886	2.660448e-06	5.575	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	3.722827e-06	5.429	0	0
HIV Infection	R-HSA-162906	3.820374e-06	5.418	0	0
PKR-mediated signaling	R-HSA-9833482	4.497979e-06	5.347	0	0
Ub-specific processing proteases	R-HSA-5689880	4.528359e-06	5.344	0	0
Oncogenic MAPK signaling	R-HSA-6802957	4.680490e-06	5.330	0	0
Base Excision Repair	R-HSA-73884	5.853698e-06	5.233	0	0
Chromatin organization	R-HSA-4839726	6.506030e-06	5.187	0	0
L1CAM interactions	R-HSA-373760	6.535963e-06	5.185	0	0
Signaling by RAF1 mutants	R-HSA-9656223	6.846341e-06	5.165	0	0
Cell-extracellular matrix interactions	R-HSA-446353	7.619583e-06	5.118	0	0
Macroautophagy	R-HSA-1632852	8.254166e-06	5.083	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	8.333594e-06	5.079	0	0
Signaling by NOTCH	R-HSA-157118	8.773135e-06	5.057	0	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	9.475896e-06	5.023	0	0
HCMV Early Events	R-HSA-9609690	1.004429e-05	4.998	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.018830e-05	4.992	0	0
Host Interactions of HIV factors	R-HSA-162909	1.019369e-05	4.992	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	1.032779e-05	4.986	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	1.038605e-05	4.984	0	0
Signaling by WNT	R-HSA-195721	1.397430e-05	4.855	0	0
Regulation of CDH1 Function	R-HSA-9764561	1.415024e-05	4.849	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.440302e-05	4.842	0	0
Amyloid fiber formation	R-HSA-977225	1.483600e-05	4.829	0	0
Reproduction	R-HSA-1474165	1.529795e-05	4.815	0	0
Membrane Trafficking	R-HSA-199991	1.558797e-05	4.807	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	1.719231e-05	4.765	0	0
Metalloprotease DUBs	R-HSA-5689901	1.983321e-05	4.703	0	0
Nephrin family interactions	R-HSA-373753	2.445643e-05	4.612	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	2.805895e-05	4.552	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	2.637774e-05	4.579	0	0
Translation	R-HSA-72766	2.745105e-05	4.561	0	0
Signaling by ERBB2	R-HSA-1227986	2.813350e-05	4.551	0	0
SARS-CoV-2 Infection	R-HSA-9694516	2.926303e-05	4.534	0	0
Signaling by Interleukins	R-HSA-449147	2.984758e-05	4.525	1	0
Cleavage of the damaged pyrimidine	R-HSA-110329	2.993069e-05	4.524	0	0
Depyrimidination	R-HSA-73928	2.993069e-05	4.524	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	3.106644e-05	4.508	0	0
ISG15 antiviral mechanism	R-HSA-1169408	3.149123e-05	4.502	0	0
Signaling by Hippo	R-HSA-2028269	3.151303e-05	4.502	0	0
Co-inhibition by PD-1	R-HSA-389948	3.179339e-05	4.498	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	4.110323e-05	4.386	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	4.590716e-05	4.338	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	4.723797e-05	4.326	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	4.723797e-05	4.326	0	0
Ephrin signaling	R-HSA-3928664	4.798256e-05	4.319	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	5.001894e-05	4.301	0	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	5.120839e-05	4.291	0	0
Post NMDA receptor activation events	R-HSA-438064	5.428403e-05	4.265	0	0
mRNA Splicing	R-HSA-72172	5.543522e-05	4.256	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	6.279457e-05	4.202	0	0
Signaling by ERBB4	R-HSA-1236394	6.735314e-05	4.172	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	7.340997e-05	4.134	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	6.866453e-05	4.163	0	0
Epigenetic regulation of gene expression	R-HSA-212165	7.744904e-05	4.111	0	0
Telomere Maintenance	R-HSA-157579	7.094716e-05	4.149	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	7.509036e-05	4.124	0	0
Signaling by ALK in cancer	R-HSA-9700206	7.509036e-05	4.124	0	0
Kinesins	R-HSA-983189	7.820905e-05	4.107	0	0
RAF activation	R-HSA-5673000	9.088409e-05	4.042	0	0
Downregulation of ERBB4 signaling	R-HSA-1253288	9.470048e-05	4.024	0	0
UCH proteinases	R-HSA-5689603	9.737384e-05	4.012	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	1.064642e-04	3.973	0	0
S Phase	R-HSA-69242	1.077040e-04	3.968	0	0
MAPK family signaling cascades	R-HSA-5683057	1.179178e-04	3.928	0	0
Nucleotide Excision Repair	R-HSA-5696398	1.244799e-04	3.905	0	0
SARS-CoV Infections	R-HSA-9679506	1.263713e-04	3.898	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	1.364620e-04	3.865	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	1.394163e-04	3.856	0	0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	1.407517e-04	3.852	0	0
Semaphorin interactions	R-HSA-373755	1.426289e-04	3.846	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	1.450340e-04	3.839	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.488896e-04	3.827	0	0
HCMV Infection	R-HSA-9609646	1.496214e-04	3.825	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	1.548405e-04	3.810	0	0
HIV Life Cycle	R-HSA-162587	1.587230e-04	3.799	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	1.623720e-04	3.789	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	1.674827e-04	3.776	0	0
Interferon Signaling	R-HSA-913531	1.737628e-04	3.760	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	1.861780e-04	3.730	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	1.917683e-04	3.717	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	1.952696e-04	3.709	0	0
Transport of connexons to the plasma membrane	R-HSA-190872	2.052200e-04	3.688	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	2.058002e-04	3.687	0	0
MAP2K and MAPK activation	R-HSA-5674135	2.202478e-04	3.657	0	0
AURKA Activation by TPX2	R-HSA-8854518	2.501936e-04	3.602	0	0
Josephin domain DUBs	R-HSA-5689877	2.898402e-04	3.538	0	0
Folding of actin by CCT/TriC	R-HSA-390450	2.898402e-04	3.538	0	0
mTORC1-mediated signalling	R-HSA-166208	2.894651e-04	3.538	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	3.009433e-04	3.522	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	2.712021e-04	3.567	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	3.019591e-04	3.520	0	0
Chaperonin-mediated protein folding	R-HSA-390466	3.023981e-04	3.519	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	3.217810e-04	3.492	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	3.217810e-04	3.492	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	3.231659e-04	3.491	0	0
Protein folding	R-HSA-391251	3.320259e-04	3.479	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	3.566898e-04	3.448	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	3.579356e-04	3.446	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	3.644439e-04	3.438	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	3.644439e-04	3.438	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	3.649426e-04	3.438	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	3.778704e-04	3.423	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	3.895030e-04	3.409	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	4.208259e-04	3.376	0	0
EPHB-mediated forward signaling	R-HSA-3928662	4.287586e-04	3.368	0	0
RMTs methylate histone arginines	R-HSA-3214858	4.287586e-04	3.368	0	0
Protein ubiquitination	R-HSA-8852135	4.805041e-04	3.318	0	0
Neutrophil degranulation	R-HSA-6798695	4.842468e-04	3.315	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	5.292163e-04	3.276	0	0
Neurodegenerative Diseases	R-HSA-8863678	5.292163e-04	3.276	0	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	5.633840e-04	3.249	0	0
Signaling by VEGF	R-HSA-194138	5.919666e-04	3.228	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	7.120713e-04	3.147	0	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	7.329432e-04	3.135	0	0
Reduction of cytosolic Ca++ levels	R-HSA-418359	7.329432e-04	3.135	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	7.663040e-04	3.116	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	7.892047e-04	3.103	0	0
RAF/MAP kinase cascade	R-HSA-5673001	8.031640e-04	3.095	0	0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	8.054624e-04	3.094	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	8.118933e-04	3.091	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	8.118933e-04	3.091	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	9.284174e-04	3.032	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	9.649445e-04	3.015	0	0
Nef and signal transduction	R-HSA-164944	1.090565e-03	2.962	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.144377e-03	2.941	0	0
Gap junction trafficking and regulation	R-HSA-157858	1.152505e-03	2.938	0	0
Gap junction trafficking	R-HSA-190828	1.159080e-03	2.936	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	1.272126e-03	2.895	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	1.292902e-03	2.888	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	1.339681e-03	2.873	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	1.606941e-03	2.794	0	0
Post-chaperonin tubulin folding pathway	R-HSA-389977	1.491305e-03	2.826	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.491305e-03	2.826	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	1.518789e-03	2.819	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	1.608770e-03	2.794	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	1.597421e-03	2.797	0	0
Ion homeostasis	R-HSA-5578775	1.591035e-03	2.798	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	1.606941e-03	2.794	0	0
Infectious disease	R-HSA-5663205	1.505007e-03	2.822	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	1.629407e-03	2.788	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.704571e-03	2.768	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.827864e-03	2.738	0	0
Regulation of PTEN localization	R-HSA-8948747	1.848287e-03	2.733	0	0
Late endosomal microautophagy	R-HSA-9615710	1.923505e-03	2.716	0	0
HCMV Late Events	R-HSA-9610379	1.923594e-03	2.716	0	0
Orc1 removal from chromatin	R-HSA-68949	1.957593e-03	2.708	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	2.014174e-03	2.696	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	2.024164e-03	2.694	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	2.060974e-03	2.686	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	2.159111e-03	2.666	0	0
G1/S Transition	R-HSA-69206	2.189152e-03	2.660	0	0
PECAM1 interactions	R-HSA-210990	2.213293e-03	2.655	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	2.213293e-03	2.655	0	0
Sema4D in semaphorin signaling	R-HSA-400685	2.246406e-03	2.649	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	2.279052e-03	2.642	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	2.412616e-03	2.618	0	0
Centrosome maturation	R-HSA-380287	2.423431e-03	2.616	0	0
Nuclear import of Rev protein	R-HSA-180746	2.494494e-03	2.603	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	2.510586e-03	2.600	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	2.613097e-03	2.583	0	0
COPI-mediated anterograde transport	R-HSA-6807878	2.842477e-03	2.546	0	0
Degradation of CDH1	R-HSA-9766229	2.853524e-03	2.545	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	2.950003e-03	2.530	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	2.950003e-03	2.530	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	2.998586e-03	2.523	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	3.031656e-03	2.518	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	3.031656e-03	2.518	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	3.153977e-03	2.501	0	0
Intracellular signaling by second messengers	R-HSA-9006925	3.161501e-03	2.500	1	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	3.226145e-03	2.491	0	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	3.226145e-03	2.491	0	0
Signaling by AMER1 mutants	R-HSA-4839748	3.226145e-03	2.491	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	3.226145e-03	2.491	0	0
PTEN Regulation	R-HSA-6807070	3.227496e-03	2.491	0	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	3.330643e-03	2.477	0	0
Signaling by KIT in disease	R-HSA-9669938	3.330643e-03	2.477	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	3.357876e-03	2.474	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	3.447228e-03	2.463	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	3.581663e-03	2.446	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	3.628725e-03	2.440	0	0
Gap junction degradation	R-HSA-190873	4.481024e-03	2.349	0	0
p75NTR recruits signalling complexes	R-HSA-209543	4.559259e-03	2.341	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	4.559259e-03	2.341	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	4.559259e-03	2.341	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	4.559259e-03	2.341	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	4.559259e-03	2.341	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	4.559259e-03	2.341	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	4.559259e-03	2.341	0	0
Ovarian tumor domain proteases	R-HSA-5689896	4.466491e-03	2.350	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	4.466491e-03	2.350	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	4.466491e-03	2.350	0	0
Signaling by EGFR	R-HSA-177929	3.720161e-03	2.429	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	4.466491e-03	2.350	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	4.353244e-03	2.361	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	4.454055e-03	2.351	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	3.679877e-03	2.434	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	4.481024e-03	2.349	0	0
Switching of origins to a post-replicative state	R-HSA-69052	3.941131e-03	2.404	0	0
Cellular response to chemical stress	R-HSA-9711123	4.516324e-03	2.345	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	4.339976e-03	2.363	0	0
Regulation of signaling by CBL	R-HSA-912631	3.822646e-03	2.418	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	3.720161e-03	2.429	0	0
Signaling by PTK6	R-HSA-8848021	4.636658e-03	2.334	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	4.636658e-03	2.334	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	4.664145e-03	2.331	0	0
PIP3 activates AKT signaling	R-HSA-1257604	4.666988e-03	2.331	1	1
Co-inhibition by CTLA4	R-HSA-389513	4.952223e-03	2.305	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	5.287020e-03	2.277	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	5.333772e-03	2.273	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	5.370846e-03	2.270	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	5.487280e-03	2.261	0	0
Synthesis of DNA	R-HSA-69239	5.555639e-03	2.255	0	0
Immune System	R-HSA-168256	5.642101e-03	2.249	1	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	5.667239e-03	2.247	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	5.667239e-03	2.247	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	5.667239e-03	2.247	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	5.992490e-03	2.222	0	0
Vesicle-mediated transport	R-HSA-5653656	6.056509e-03	2.218	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	6.072298e-03	2.217	0	0
Membrane binding and targetting of GAG proteins	R-HSA-174490	6.270685e-03	2.203	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	6.324991e-03	2.199	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	6.324991e-03	2.199	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	6.324991e-03	2.199	0	0
Basigin interactions	R-HSA-210991	6.324991e-03	2.199	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	6.529840e-03	2.185	0	0
Pexophagy	R-HSA-9664873	6.529840e-03	2.185	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	6.529840e-03	2.185	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	6.592212e-03	2.181	0	0
Dual Incision in GG-NER	R-HSA-5696400	6.592212e-03	2.181	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	6.592212e-03	2.181	0	0
Mitophagy	R-HSA-5205647	6.592212e-03	2.181	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	6.592212e-03	2.181	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	6.700751e-03	2.174	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	7.025667e-03	2.153	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	7.180576e-03	2.144	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	7.194614e-03	2.143	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	7.194614e-03	2.143	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	7.194614e-03	2.143	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	7.535736e-03	2.123	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	7.535736e-03	2.123	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	7.880400e-03	2.103	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	7.880400e-03	2.103	0	0
Regulation of Apoptosis	R-HSA-169911	7.880400e-03	2.103	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	7.892855e-03	2.103	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	8.114645e-03	2.091	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	8.114645e-03	2.091	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	8.253316e-03	2.083	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	8.253316e-03	2.083	0	0
Hedgehog 'off' state	R-HSA-5610787	8.419808e-03	2.075	0	0
Glycolysis	R-HSA-70171	8.419808e-03	2.075	0	0
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	8.419945e-03	2.075	0	0
tRNA processing in the nucleus	R-HSA-6784531	8.646907e-03	2.063	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	8.646907e-03	2.063	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	8.865261e-03	2.052	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	8.865261e-03	2.052	0	0
Signaling by NOTCH4	R-HSA-9013694	9.155876e-03	2.038	0	0
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	9.174151e-03	2.037	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	9.174151e-03	2.037	0	0
Signaling by APC mutants	R-HSA-4839744	9.185335e-03	2.037	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	9.185335e-03	2.037	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	9.185335e-03	2.037	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	9.185335e-03	2.037	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	9.185335e-03	2.037	0	0
RET signaling	R-HSA-8853659	9.357763e-03	2.029	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	9.357763e-03	2.029	0	0
Adaptive Immune System	R-HSA-1280218	9.458795e-03	2.024	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	9.475619e-03	2.023	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	9.475619e-03	2.023	0	0
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	1.232163e-02	1.909	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	1.232163e-02	1.909	0	0
FLT3 signaling by CBL mutants	R-HSA-9706377	1.232163e-02	1.909	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	1.106673e-02	1.956	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	1.106673e-02	1.956	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	1.106673e-02	1.956	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	1.197308e-02	1.922	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	1.162725e-02	1.935	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	1.162725e-02	1.935	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	1.037202e-02	1.984	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	9.665125e-03	2.015	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	1.117684e-02	1.952	0	0
mRNA 3'-end processing	R-HSA-72187	1.029721e-02	1.987	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	1.029721e-02	1.987	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	1.179644e-02	1.928	0	0
Metabolism of non-coding RNA	R-HSA-194441	1.225554e-02	1.912	0	0
snRNP Assembly	R-HSA-191859	1.225554e-02	1.912	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	1.028880e-02	1.988	0	0
p75NTR signals via NF-kB	R-HSA-193639	1.106673e-02	1.956	0	0
MTOR signalling	R-HSA-165159	1.207096e-02	1.918	0	0
Integration of provirus	R-HSA-162592	1.253410e-02	1.902	0	0
Rap1 signalling	R-HSA-392517	1.197308e-02	1.922	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	9.973035e-03	2.001	0	0
Degradation of DVL	R-HSA-4641258	1.104179e-02	1.957	0	0
Regulation of mitotic cell cycle	R-HSA-453276	1.278258e-02	1.893	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	1.278258e-02	1.893	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	1.037202e-02	1.984	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	1.037202e-02	1.984	0	0
NF-kB is activated and signals survival	R-HSA-209560	1.253410e-02	1.902	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	1.222561e-02	1.913	0	0
Gene expression (Transcription)	R-HSA-74160	1.124869e-02	1.949	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	9.941626e-03	2.003	0	0
Signaling by AXIN mutants	R-HSA-4839735	1.253410e-02	1.902	0	0
Cilium Assembly	R-HSA-5617833	1.084764e-02	1.965	0	0
Hemostasis	R-HSA-109582	1.204642e-02	1.919	0	0
MHC class II antigen presentation	R-HSA-2132295	9.607712e-03	2.017	0	0
Co-stimulation by CD28	R-HSA-389356	1.286690e-02	1.891	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	1.295025e-02	1.888	0	0
Formation of annular gap junctions	R-HSA-196025	1.336175e-02	1.874	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	1.336175e-02	1.874	0	0
TCR signaling	R-HSA-202403	1.338181e-02	1.873	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	1.346113e-02	1.871	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	1.376859e-02	1.861	0	0
Vpu mediated degradation of CD4	R-HSA-180534	1.376859e-02	1.861	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	1.376859e-02	1.861	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	1.388845e-02	1.857	0	0
Signaling by SCF-KIT	R-HSA-1433557	1.397720e-02	1.855	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	1.426960e-02	1.846	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	1.431700e-02	1.844	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.437183e-02	1.842	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	1.445132e-02	1.840	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	1.445132e-02	1.840	0	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	1.445132e-02	1.840	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	1.445132e-02	1.840	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	1.445132e-02	1.840	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	1.445132e-02	1.840	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	1.445132e-02	1.840	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	1.445132e-02	1.840	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	1.445132e-02	1.840	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	1.445132e-02	1.840	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	1.445132e-02	1.840	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	1.445132e-02	1.840	0	0
Platelet calcium homeostasis	R-HSA-418360	1.445433e-02	1.840	0	0
Platelet degranulation	R-HSA-114608	1.471079e-02	1.832	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	1.489652e-02	1.827	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	1.489652e-02	1.827	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	1.492339e-02	1.826	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	1.492339e-02	1.826	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	1.492339e-02	1.826	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	1.492339e-02	1.826	0	0
Stabilization of p53	R-HSA-69541	1.510106e-02	1.821	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	1.530270e-02	1.815	0	0
Signaling by NOTCH3	R-HSA-9012852	1.530270e-02	1.815	0	0
Sensory processing of sound	R-HSA-9659379	1.598474e-02	1.796	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	1.610600e-02	1.793	0	0
Gap junction assembly	R-HSA-190861	1.619524e-02	1.791	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	1.665794e-02	1.778	0	0
VLDLR internalisation and degradation	R-HSA-8866427	1.665794e-02	1.778	0	0
Regulation of RAS by GAPs	R-HSA-5658442	1.683446e-02	1.774	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	1.719004e-02	1.765	0	0
Activation of BH3-only proteins	R-HSA-114452	1.719004e-02	1.765	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	1.733265e-02	1.761	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	1.751215e-02	1.757	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	1.779223e-02	1.750	0	0
Long-term potentiation	R-HSA-9620244	1.797396e-02	1.745	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	1.836826e-02	1.736	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	1.847258e-02	1.733	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	1.847258e-02	1.733	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	1.847258e-02	1.733	0	0
GP1b-IX-V activation signalling	R-HSA-430116	1.867697e-02	1.729	0	0
Signalling to ERKs	R-HSA-187687	1.892848e-02	1.723	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	1.892848e-02	1.723	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	1.892848e-02	1.723	0	0
Maturation of protein E	R-HSA-9683683	1.908351e-02	1.719	0	0
Maturation of protein E	R-HSA-9694493	1.908351e-02	1.719	0	0
Death Receptor Signaling	R-HSA-73887	2.014650e-02	1.696	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	2.020128e-02	1.695	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	2.020128e-02	1.695	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	2.020128e-02	1.695	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	2.029015e-02	1.693	0	0
Signaling by NTRKs	R-HSA-166520	2.094678e-02	1.679	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	2.109208e-02	1.676	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	2.148944e-02	1.668	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	2.148944e-02	1.668	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	2.158475e-02	1.666	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	2.234753e-02	1.651	0	0
Signaling by PDGFR in disease	R-HSA-9671555	2.234753e-02	1.651	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	2.234753e-02	1.651	0	0
Assembly Of The HIV Virion	R-HSA-175474	2.234753e-02	1.651	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	2.256478e-02	1.647	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	2.256478e-02	1.647	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	2.445116e-02	1.612	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	2.453427e-02	1.610	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	2.522244e-02	1.598	0	0
2-LTR circle formation	R-HSA-164843	2.522244e-02	1.598	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	2.522244e-02	1.598	0	0
Degradation of AXIN	R-HSA-4641257	2.539772e-02	1.595	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	2.539772e-02	1.595	0	0
ER-Phagosome pathway	R-HSA-1236974	2.570128e-02	1.590	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.625037e-02	1.581	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	2.648305e-02	1.577	0	0
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	2.658977e-02	1.575	0	0
G alpha (12/13) signalling events	R-HSA-416482	2.676170e-02	1.572	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	2.689850e-02	1.570	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	2.689850e-02	1.570	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	2.752138e-02	1.560	0	0
Regulation of KIT signaling	R-HSA-1433559	2.752138e-02	1.560	0	0
Regulation of necroptotic cell death	R-HSA-5675482	2.768197e-02	1.558	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	2.768197e-02	1.558	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	2.775776e-02	1.557	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	2.775776e-02	1.557	0	0
CREB phosphorylation	R-HSA-199920	2.776529e-02	1.556	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	3.010906e-02	1.521	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	3.061490e-02	1.514	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	3.061490e-02	1.514	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	3.061490e-02	1.514	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	3.070671e-02	1.513	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	3.845759e-02	1.415	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	3.438273e-02	1.464	0	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	3.438273e-02	1.464	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	3.438273e-02	1.464	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	3.370621e-02	1.472	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	4.044640e-02	1.393	0	0
Deadenylation of mRNA	R-HSA-429947	3.784854e-02	1.422	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	4.430447e-02	1.354	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	4.292200e-02	1.367	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	3.447165e-02	1.463	0	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	3.681431e-02	1.434	0	0
EGFR downregulation	R-HSA-182971	4.661884e-02	1.331	0	0
PKMTs methylate histone lysines	R-HSA-3214841	4.288321e-02	1.368	0	0
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	4.230475e-02	1.374	0	0
Prolonged ERK activation events	R-HSA-169893	4.226008e-02	1.374	0	0
Activation of the pre-replicative complex	R-HSA-68962	4.050392e-02	1.393	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	4.311189e-02	1.365	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	3.679175e-02	1.434	0	0
Regulation of TP53 Activity	R-HSA-5633007	4.572397e-02	1.340	0	0
DCC mediated attractive signaling	R-HSA-418885	3.438273e-02	1.464	0	0
Trafficking of AMPA receptors	R-HSA-399719	4.661884e-02	1.331	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	4.290224e-02	1.368	0	0
RNA Polymerase II Transcription	R-HSA-73857	3.899794e-02	1.409	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	4.661884e-02	1.331	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	3.776557e-02	1.423	0	0
PCP/CE pathway	R-HSA-4086400	4.752957e-02	1.323	0	0
Cellular response to hypoxia	R-HSA-1234174	4.592208e-02	1.338	0	0
Signaling by NOTCH2	R-HSA-1980145	3.681431e-02	1.434	0	0
Negative regulation of MET activity	R-HSA-6807004	4.044640e-02	1.393	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	3.840930e-02	1.416	0	0
NRAGE signals death through JNK	R-HSA-193648	3.437233e-02	1.464	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	4.081581e-02	1.389	0	0
Antigen processing-Cross presentation	R-HSA-1236975	3.283825e-02	1.484	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	3.776557e-02	1.423	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	4.725887e-02	1.326	0	0
Cation-coupled Chloride cotransporters	R-HSA-426117	3.845759e-02	1.415	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	3.840930e-02	1.416	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	4.478524e-02	1.349	0	0
Spry regulation of FGF signaling	R-HSA-1295596	3.438273e-02	1.464	0	0
Hedgehog 'on' state	R-HSA-5632684	4.478524e-02	1.349	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	3.333507e-02	1.477	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	3.848906e-02	1.415	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	4.292200e-02	1.367	0	0
Glucose metabolism	R-HSA-70326	4.561672e-02	1.341	0	0
Disease	R-HSA-1643685	3.632032e-02	1.440	1	0
FLT3 Signaling	R-HSA-9607240	4.288321e-02	1.368	0	0
Negative regulation of FLT3	R-HSA-9706369	4.226008e-02	1.374	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	4.288321e-02	1.368	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	3.840930e-02	1.416	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	4.770054e-02	1.321	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	4.778951e-02	1.321	1	0
Degradation of CRY and PER proteins	R-HSA-9932298	4.830007e-02	1.316	0	0
Developmental Cell Lineages	R-HSA-9734767	4.859416e-02	1.313	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.118571e-02	1.291	0	0
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	5.118571e-02	1.291	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	5.119444e-02	1.291	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	5.119444e-02	1.291	0	0
Myoclonic epilepsy of Lafora	R-HSA-3785653	5.119444e-02	1.291	0	0
Modulation by Mtb of host immune system	R-HSA-9637628	5.119444e-02	1.291	0	0
Myogenesis	R-HSA-525793	5.144498e-02	1.289	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	5.172467e-02	1.286	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	5.172467e-02	1.286	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	5.172467e-02	1.286	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	5.172467e-02	1.286	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	5.172467e-02	1.286	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	5.293369e-02	1.276	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	5.293369e-02	1.276	0	0
IRAK1 recruits IKK complex	R-HSA-937039	5.293369e-02	1.276	0	0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	5.293369e-02	1.276	0	0
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	5.293369e-02	1.276	0	0
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	5.293369e-02	1.276	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	5.416288e-02	1.266	0	0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway	R-HSA-73930	5.516042e-02	1.258	0	0
Manipulation of host energy metabolism	R-HSA-9636667	5.516042e-02	1.258	0	0
Breakdown of the nuclear lamina	R-HSA-352238	5.516042e-02	1.258	0	0
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	5.641220e-02	1.249	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	5.641220e-02	1.249	0	0
MAP kinase activation	R-HSA-450294	5.686484e-02	1.245	0	0
Signaling by Hedgehog	R-HSA-5358351	5.863810e-02	1.232	0	0
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	5.905114e-02	1.229	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	5.928709e-02	1.227	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	5.928709e-02	1.227	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	5.928709e-02	1.227	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	5.928709e-02	1.227	0	0
Integrin signaling	R-HSA-354192	6.061475e-02	1.217	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	6.061475e-02	1.217	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	6.061475e-02	1.217	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	6.061475e-02	1.217	0	0
Activation of ATR in response to replication stress	R-HSA-176187	6.061475e-02	1.217	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	6.090296e-02	1.215	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	6.126250e-02	1.213	0	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	6.126250e-02	1.213	0	0
Frs2-mediated activation	R-HSA-170968	6.497702e-02	1.187	0	0
ARMS-mediated activation	R-HSA-170984	6.595861e-02	1.181	0	0
ALK mutants bind TKIs	R-HSA-9700645	6.595861e-02	1.181	0	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	6.595861e-02	1.181	0	0
Cellular response to mitochondrial stress	R-HSA-9840373	6.595861e-02	1.181	0	0
G1 Phase	R-HSA-69236	6.726777e-02	1.172	0	0
Cyclin D associated events in G1	R-HSA-69231	6.726777e-02	1.172	0	0
Signaling by TGFB family members	R-HSA-9006936	6.744308e-02	1.171	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	6.771882e-02	1.169	1	1
HIV elongation arrest and recovery	R-HSA-167287	6.784280e-02	1.168	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	6.784280e-02	1.168	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	6.821969e-02	1.166	0	0
Resolution of D-Loop Structures	R-HSA-5693537	6.852041e-02	1.164	0	0
Signaling by NOTCH1	R-HSA-1980143	6.876422e-02	1.163	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	7.045497e-02	1.152	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	7.154254e-02	1.145	0	0
GAB1 signalosome	R-HSA-180292	7.224866e-02	1.141	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	7.260745e-02	1.139	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	7.260745e-02	1.139	0	0
Generic Transcription Pathway	R-HSA-212436	7.357516e-02	1.133	0	0
Syndecan interactions	R-HSA-3000170	7.580115e-02	1.120	0	0
Interleukin-1 signaling	R-HSA-9020702	7.696759e-02	1.114	1	1
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	7.704164e-02	1.113	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	7.704164e-02	1.113	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	7.704164e-02	1.113	0	0
Dual incision in TC-NER	R-HSA-6782135	7.708935e-02	1.113	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	7.711896e-02	1.113	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	7.711896e-02	1.113	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	7.780537e-02	1.109	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	7.842374e-02	1.106	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	7.842374e-02	1.106	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	7.945134e-02	1.100	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	8.063302e-02	1.093	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	8.063302e-02	1.093	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	8.063302e-02	1.093	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	8.063302e-02	1.093	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	8.226065e-02	1.085	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	8.268811e-02	1.083	0	0
Regulation of CDH11 function	R-HSA-9762292	8.268811e-02	1.083	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	8.268811e-02	1.083	0	0
MITF-M-dependent gene expression	R-HSA-9856651	8.294952e-02	1.081	0	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	8.438849e-02	1.074	0	0
Translesion Synthesis by POLH	R-HSA-110320	8.438849e-02	1.074	0	0
STING mediated induction of host immune responses	R-HSA-1834941	8.438849e-02	1.074	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	8.446417e-02	1.073	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	8.589332e-02	1.066	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	8.618162e-02	1.065	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	8.676106e-02	1.062	0	0
Regulation of TP53 Expression	R-HSA-6804754	9.049609e-02	1.043	0	0
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	9.049609e-02	1.043	0	0
Signaling by FGFR2	R-HSA-5654738	9.322540e-02	1.030	0	0
Signaling by MET	R-HSA-6806834	9.322540e-02	1.030	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	9.324239e-02	1.030	0	0
p38MAPK events	R-HSA-171007	9.324239e-02	1.030	0	0
Translesion synthesis by REV1	R-HSA-110312	9.324239e-02	1.030	0	0
Protein methylation	R-HSA-8876725	9.324239e-02	1.030	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	9.324239e-02	1.030	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	9.346200e-02	1.029	0	0
Regulation of TP53 Degradation	R-HSA-6804757	9.593979e-02	1.018	0	0
FLT3 signaling in disease	R-HSA-9682385	9.593979e-02	1.018	0	0
Signal transduction by L1	R-HSA-445144	9.758239e-02	1.011	0	0
Protein hydroxylation	R-HSA-9629569	9.758239e-02	1.011	0	0
Budding and maturation of HIV virion	R-HSA-162588	9.783392e-02	1.010	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	9.833402e-02	1.007	1	1
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	9.833402e-02	1.007	1	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	9.833402e-02	1.007	1	0
HDMs demethylate histones	R-HSA-3214842	9.863719e-02	1.006	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	9.932970e-02	1.003	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	9.932970e-02	1.003	0	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	1.012833e-01	0.994	0	0
ChREBP activates metabolic gene expression	R-HSA-163765	1.012833e-01	0.994	0	0
Signaling by LTK in cancer	R-HSA-9842640	1.050932e-01	0.978	0	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	1.050932e-01	0.978	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	1.051745e-01	0.978	0	0
DNA Damage Bypass	R-HSA-73893	1.083442e-01	0.965	0	0
G0 and Early G1	R-HSA-1538133	1.092605e-01	0.962	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	1.092605e-01	0.962	0	0
DNA strand elongation	R-HSA-69190	1.092605e-01	0.962	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	1.092605e-01	0.962	0	0
Signaling by WNT in cancer	R-HSA-4791275	1.092605e-01	0.962	0	0
Translesion synthesis by POLI	R-HSA-5656121	1.093830e-01	0.961	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	1.093830e-01	0.961	0	0
Regulation of NF-kappa B signaling	R-HSA-9758274	1.093830e-01	0.961	0	0
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	1.177326e-01	0.929	0	0
Deletions in the AMER1 gene destabilize the destruction complex	R-HSA-5467343	1.177326e-01	0.929	0	0
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	1.177326e-01	0.929	0	0
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.177326e-01	0.929	0	0
Loss of Function of TP53 in Cancer	R-HSA-9723907	1.177326e-01	0.929	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	2.216102e-01	0.654	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.216102e-01	0.654	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.216102e-01	0.654	0	0
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	2.216102e-01	0.654	0	0
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	2.216102e-01	0.654	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.216102e-01	0.654	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.216102e-01	0.654	0	0
Hereditary fructose intolerance	R-HSA-5657560	2.216102e-01	0.654	0	0
TICAM1 deficiency - HSE	R-HSA-5602566	2.216102e-01	0.654	0	0
RPIA deficiency: failed conversion of RU5P to R5P	R-HSA-6791461	2.216102e-01	0.654	0	0
RPIA deficiency: failed conversion of R5P to RU5P	R-HSA-5659996	2.216102e-01	0.654	0	0
SARS-CoV-1 targets PDZ proteins in cell-cell junction	R-HSA-9692912	2.216102e-01	0.654	0	0
Impaired BRCA2 binding to SEM1 (DSS1)	R-HSA-9763198	2.216102e-01	0.654	0	0
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	2.216102e-01	0.654	0	0
Impaired BRCA2 translocation to the nucleus	R-HSA-9709275	2.216102e-01	0.654	0	0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	1.306094e-01	0.884	0	0
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	1.306094e-01	0.884	0	0
Regulation of gap junction activity	R-HSA-191650	1.738868e-01	0.760	0	0
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	1.738868e-01	0.760	0	0
NADE modulates death signalling	R-HSA-205025	1.738868e-01	0.760	0	0
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	1.738868e-01	0.760	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	1.738868e-01	0.760	0	0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	1.738868e-01	0.760	0	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	1.738868e-01	0.760	0	0
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	1.738868e-01	0.760	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	1.320541e-01	0.879	0	0
Disinhibition of SNARE formation	R-HSA-114516	1.320541e-01	0.879	0	0
Recycling of eIF2:GDP	R-HSA-72731	1.320541e-01	0.879	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.190281e-01	0.660	0	0
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	2.190281e-01	0.660	0	0
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	2.190281e-01	0.660	0	0
Type I hemidesmosome assembly	R-HSA-446107	1.611166e-01	0.793	0	0
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	1.611166e-01	0.793	0	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	1.435273e-01	0.843	0	0
Repression of WNT target genes	R-HSA-4641265	1.435273e-01	0.843	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	1.435273e-01	0.843	0	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	1.918786e-01	0.717	0	0
Lipophagy	R-HSA-9613354	1.918786e-01	0.717	0	0
Calcineurin activates NFAT	R-HSA-2025928	1.918786e-01	0.717	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	1.267793e-01	0.897	0	0
G beta:gamma signalling through CDC42	R-HSA-8964616	1.267793e-01	0.897	0	0
Translesion synthesis by POLK	R-HSA-5655862	1.267793e-01	0.897	0	0
CD28 dependent Vav1 pathway	R-HSA-389359	1.668520e-01	0.778	0	0
Formation of axial mesoderm	R-HSA-9796292	1.668520e-01	0.778	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	1.668520e-01	0.778	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	1.668520e-01	0.778	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	1.453511e-01	0.838	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	1.453511e-01	0.838	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	1.270122e-01	0.896	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.914066e-01	0.718	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	1.113225e-01	0.953	0	0
FGFR2 alternative splicing	R-HSA-6803529	1.431636e-01	0.844	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	1.431636e-01	0.844	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	1.248250e-01	0.904	0	0
Processive synthesis on the lagging strand	R-HSA-69183	2.170036e-01	0.664	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	2.170036e-01	0.664	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	1.541602e-01	0.812	0	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	1.541602e-01	0.812	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	1.541602e-01	0.812	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	2.071608e-01	0.684	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.699182e-01	0.770	0	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	2.159975e-01	0.666	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	1.460308e-01	0.836	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	1.386843e-01	0.858	0	0
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	1.580831e-01	0.801	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	1.497098e-01	0.825	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	2.210072e-01	0.656	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	1.657304e-01	0.781	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	1.316287e-01	0.881	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	1.699182e-01	0.770	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	1.431636e-01	0.844	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	1.537269e-01	0.813	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	1.118028e-01	0.952	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	1.555377e-01	0.808	0	0
Polo-like kinase mediated events	R-HSA-156711	1.650069e-01	0.782	0	0
TNF signaling	R-HSA-75893	1.126795e-01	0.948	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	1.749221e-01	0.757	0	0
Activation of NOXA and translocation to mitochondria	R-HSA-111448	1.738868e-01	0.760	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	1.270122e-01	0.896	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	2.210072e-01	0.656	0	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	1.341844e-01	0.872	0	0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	1.918786e-01	0.717	0	0
Generation of second messenger molecules	R-HSA-202433	1.410139e-01	0.851	0	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	1.738868e-01	0.760	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	1.270122e-01	0.896	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	2.170036e-01	0.664	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	1.181794e-01	0.927	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	1.498401e-01	0.824	1	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	1.172898e-01	0.931	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	1.418373e-01	0.848	0	0
Proteasome assembly	R-HSA-9907900	2.097252e-01	0.678	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	1.918786e-01	0.717	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	2.170036e-01	0.664	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	1.856460e-01	0.731	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	1.328157e-01	0.877	1	1
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	2.159975e-01	0.666	0	0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	1.267793e-01	0.897	1	1
Interleukin-17 signaling	R-HSA-448424	1.188174e-01	0.925	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	1.256672e-01	0.901	1	1
Detoxification of Reactive Oxygen Species	R-HSA-3299685	1.126795e-01	0.948	0	0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	2.170036e-01	0.664	0	0
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	2.170036e-01	0.664	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	1.391158e-01	0.857	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	1.541602e-01	0.812	0	0
Regulated Necrosis	R-HSA-5218859	1.647200e-01	0.783	0	0
Signaling by FGFR4	R-HSA-5654743	1.128785e-01	0.947	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	2.073616e-01	0.683	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	1.267793e-01	0.897	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	1.637146e-01	0.786	1	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	1.892165e-01	0.723	1	0
Signaling by FGFR3	R-HSA-5654741	1.344698e-01	0.871	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	2.210072e-01	0.656	0	0
Calmodulin induced events	R-HSA-111933	1.764087e-01	0.753	0	0
Formation of editosomes by ADAR proteins	R-HSA-77042	2.216102e-01	0.654	0	0
Inhibition of PKR	R-HSA-169131	2.216102e-01	0.654	0	0
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	1.306094e-01	0.884	0	0
FLT3 signaling through SRC family kinases	R-HSA-9706374	1.738868e-01	0.760	0	0
Reelin signalling pathway	R-HSA-8866376	2.190281e-01	0.660	0	0
Unwinding of DNA	R-HSA-176974	1.918786e-01	0.717	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	1.541602e-01	0.812	0	0
CaM pathway	R-HSA-111997	1.764087e-01	0.753	0	0
Formation of paraxial mesoderm	R-HSA-9793380	1.633108e-01	0.787	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	1.248250e-01	0.904	0	0
Ion transport by P-type ATPases	R-HSA-936837	1.250834e-01	0.903	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	1.914066e-01	0.718	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	2.210072e-01	0.656	0	0
Regulation of CDH11 gene transcription	R-HSA-9762293	1.918786e-01	0.717	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	1.918786e-01	0.717	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	1.113225e-01	0.953	0	0
Somitogenesis	R-HSA-9824272	1.344698e-01	0.871	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	1.320541e-01	0.879	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	1.611166e-01	0.793	0	0
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	1.216143e-01	0.915	0	0
ABC transporter disorders	R-HSA-5619084	1.975217e-01	0.704	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	1.537269e-01	0.813	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	1.863450e-01	0.730	0	0
Ion channel transport	R-HSA-983712	1.880470e-01	0.726	0	0
Plasma lipoprotein clearance	R-HSA-8964043	1.288622e-01	0.890	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	2.033921e-01	0.692	0	0
Downstream TCR signaling	R-HSA-202424	1.237921e-01	0.907	0	0
ABC-family proteins mediated transport	R-HSA-382556	1.113133e-01	0.953	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	1.129065e-01	0.947	0	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	1.118028e-01	0.952	0	0
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	1.668520e-01	0.778	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	1.193191e-01	0.923	0	0
Oncogene Induced Senescence	R-HSA-2559585	1.617258e-01	0.791	0	0
Butyrophilin (BTN) family interactions	R-HSA-8851680	1.918786e-01	0.717	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	2.074302e-01	0.683	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	1.853508e-01	0.732	0	0
Glycogen synthesis	R-HSA-3322077	2.071608e-01	0.684	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	2.236922e-01	0.650	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	2.236922e-01	0.650	0	0
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	2.239489e-01	0.650	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	2.239489e-01	0.650	0	0
PI3K/AKT activation	R-HSA-198203	2.239489e-01	0.650	0	0
FOXO-mediated transcription	R-HSA-9614085	2.245571e-01	0.649	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	2.248729e-01	0.648	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	2.260793e-01	0.646	0	0
Cardiac conduction	R-HSA-5576891	2.291763e-01	0.640	0	0
Lagging Strand Synthesis	R-HSA-69186	2.294395e-01	0.639	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	2.294395e-01	0.639	0	0
Signalling to RAS	R-HSA-167044	2.294395e-01	0.639	0	0
Platelet homeostasis	R-HSA-418346	2.321283e-01	0.634	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	2.357651e-01	0.628	1	1
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	2.357651e-01	0.628	1	0
Transcriptional regulation by RUNX2	R-HSA-8878166	2.357651e-01	0.628	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	2.359165e-01	0.627	0	0
HIV Transcription Elongation	R-HSA-167169	2.404003e-01	0.619	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	2.404003e-01	0.619	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	2.404003e-01	0.619	0	0
Glycogen metabolism	R-HSA-8982491	2.404003e-01	0.619	0	0
Diseases of DNA repair	R-HSA-9675135	2.404170e-01	0.619	0	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	2.434537e-01	0.614	0	0
Phosphorylation of the APC/C	R-HSA-176412	2.434537e-01	0.614	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	2.434537e-01	0.614	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	2.434537e-01	0.614	0	0
Regulation of BACH1 activity	R-HSA-9708530	2.434537e-01	0.614	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	2.439973e-01	0.613	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	2.523672e-01	0.598	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	2.523672e-01	0.598	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	2.523672e-01	0.598	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	2.563681e-01	0.591	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	2.564013e-01	0.591	0	0
SARS-CoV-2 modulates autophagy	R-HSA-9754560	2.569563e-01	0.590	0	0
Bicarbonate transporters	R-HSA-425381	2.569563e-01	0.590	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	2.577210e-01	0.589	0	0
Metabolism of proteins	R-HSA-392499	2.629341e-01	0.580	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	2.632634e-01	0.580	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	2.649952e-01	0.577	0	0
Pentose phosphate pathway disease	R-HSA-6791465	2.649952e-01	0.577	0	0
PTK6 Regulates Cell Cycle	R-HSA-8849470	2.649952e-01	0.577	0	0
Noncanonical activation of NOTCH3	R-HSA-9017802	2.649952e-01	0.577	0	0
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	2.649952e-01	0.577	0	0
CDC6 association with the ORC:origin complex	R-HSA-68689	2.649952e-01	0.577	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	2.649952e-01	0.577	0	0
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	2.649952e-01	0.577	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	2.658361e-01	0.575	1	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	2.658361e-01	0.575	1	0
Disorders of Developmental Biology	R-HSA-9675151	2.705703e-01	0.568	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	2.705703e-01	0.568	0	0
SHC1 events in ERBB4 signaling	R-HSA-1250347	2.705703e-01	0.568	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	2.705703e-01	0.568	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	2.705703e-01	0.568	0	0
Intraflagellar transport	R-HSA-5620924	2.725563e-01	0.565	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	2.758289e-01	0.559	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	2.767046e-01	0.558	0	0
PERK regulates gene expression	R-HSA-381042	2.767046e-01	0.558	0	0
Signaling by FGFR1	R-HSA-5654736	2.851681e-01	0.545	0	0
Potential therapeutics for SARS	R-HSA-9679191	2.864489e-01	0.543	0	0
Transmission across Chemical Synapses	R-HSA-112315	2.868092e-01	0.542	0	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	2.905559e-01	0.537	0	0
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	2.905559e-01	0.537	0	0
PI3K events in ERBB4 signaling	R-HSA-1250342	2.905559e-01	0.537	0	0
Sensing of DNA Double Strand Breaks	R-HSA-5693548	2.905559e-01	0.537	0	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	2.905559e-01	0.537	0	0
Sodium/Calcium exchangers	R-HSA-425561	2.905559e-01	0.537	0	0
Ca-dependent events	R-HSA-111996	2.927612e-01	0.533	0	0
G1/S-Specific Transcription	R-HSA-69205	2.960275e-01	0.529	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	2.960275e-01	0.529	0	0
Signaling by FGFR	R-HSA-190236	2.963400e-01	0.528	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	2.981720e-01	0.526	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	2.981720e-01	0.526	0	0
Glycogen storage diseases	R-HSA-3229121	2.981720e-01	0.526	0	0
DAP12 signaling	R-HSA-2424491	2.985517e-01	0.525	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	2.997098e-01	0.523	0	0
Interleukin-1 family signaling	R-HSA-446652	3.057469e-01	0.515	1	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	3.109684e-01	0.507	0	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	3.109684e-01	0.507	0	0
Erythropoietin activates STAT5	R-HSA-9027283	3.109684e-01	0.507	0	0
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	3.109684e-01	0.507	0	0
Autointegration results in viral DNA circles	R-HSA-177539	3.109684e-01	0.507	0	0
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	3.109684e-01	0.507	0	0
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	3.109684e-01	0.507	0	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	3.109684e-01	0.507	0	0
Integration of viral DNA into host genomic DNA	R-HSA-175567	3.109684e-01	0.507	0	0
Circadian clock	R-HSA-9909396	3.128162e-01	0.505	0	0
NFG and proNGF binds to p75NTR	R-HSA-205017	3.132627e-01	0.504	0	0
Interactions of Tat with host cellular proteins	R-HSA-176034	3.132627e-01	0.504	0	0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	3.132627e-01	0.504	0	0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5660724	3.132627e-01	0.504	0	0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	3.132627e-01	0.504	0	0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	3.132627e-01	0.504	0	0
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	3.132627e-01	0.504	0	0
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	3.132627e-01	0.504	0	0
TRAF3 deficiency - HSE	R-HSA-5602571	3.132627e-01	0.504	0	0
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	3.132627e-01	0.504	0	0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	3.132627e-01	0.504	0	0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	3.132627e-01	0.504	0	0
PTEN Loss of Function in Cancer	R-HSA-5674404	3.132627e-01	0.504	0	0
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	3.132627e-01	0.504	0	0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5619081	3.132627e-01	0.504	0	0
Transport of connexins along the secretory pathway	R-HSA-190827	3.132627e-01	0.504	0	0
Oligomerization of connexins into connexons	R-HSA-190704	3.132627e-01	0.504	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	3.134783e-01	0.504	0	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	3.238980e-01	0.490	0	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	3.244335e-01	0.489	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	3.244335e-01	0.489	0	0
Disorders of Nervous System Development	R-HSA-9697154	3.244335e-01	0.489	0	0
Pervasive developmental disorders	R-HSA-9005895	3.244335e-01	0.489	0	0
Leading Strand Synthesis	R-HSA-69109	3.244335e-01	0.489	0	0
Polymerase switching	R-HSA-69091	3.244335e-01	0.489	0	0
Scavenging by Class F Receptors	R-HSA-3000484	3.244335e-01	0.489	0	0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	3.244335e-01	0.489	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	3.244335e-01	0.489	0	0
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	3.244335e-01	0.489	0	0
Signaling by LTK	R-HSA-9842663	3.244335e-01	0.489	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	3.260853e-01	0.487	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	3.260853e-01	0.487	0	0
Platelet sensitization by LDL	R-HSA-432142	3.260853e-01	0.487	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	3.260853e-01	0.487	0	0
MET promotes cell motility	R-HSA-8875878	3.354544e-01	0.474	0	0
Stimuli-sensing channels	R-HSA-2672351	3.384819e-01	0.470	0	0
Neurexins and neuroligins	R-HSA-6794361	3.400200e-01	0.468	0	0
Fanconi Anemia Pathway	R-HSA-6783310	3.475164e-01	0.459	0	0
DAG and IP3 signaling	R-HSA-1489509	3.475164e-01	0.459	0	0
Tight junction interactions	R-HSA-420029	3.482848e-01	0.458	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	3.482848e-01	0.458	0	0
TGFBR3 expression	R-HSA-9839394	3.482848e-01	0.458	0	0
Interleukin-7 signaling	R-HSA-1266695	3.482848e-01	0.458	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	3.541465e-01	0.451	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	3.541465e-01	0.451	0	0
The NLRP3 inflammasome	R-HSA-844456	3.541465e-01	0.451	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	3.554410e-01	0.449	0	0
MECP2 regulates transcription factors	R-HSA-9022707	3.563094e-01	0.448	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	3.563094e-01	0.448	0	0
MET activates PI3K/AKT signaling	R-HSA-8851907	3.563094e-01	0.448	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	3.563094e-01	0.448	0	0
NOSTRIN mediated eNOS trafficking	R-HSA-203641	3.563094e-01	0.448	0	0
TRIF-mediated programmed cell death	R-HSA-2562578	3.563094e-01	0.448	0	0
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	3.563094e-01	0.448	0	0
SOS-mediated signalling	R-HSA-112412	3.563094e-01	0.448	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	3.563094e-01	0.448	0	0
Nef Mediated CD4 Down-regulation	R-HSA-167590	3.563094e-01	0.448	0	0
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	3.563094e-01	0.448	0	0
Ca2+ activated K+ channels	R-HSA-1296052	3.563094e-01	0.448	0	0
CHL1 interactions	R-HSA-447041	3.563094e-01	0.448	0	0
Transcription of the HIV genome	R-HSA-167172	3.569363e-01	0.447	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	3.583073e-01	0.446	0	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	3.583073e-01	0.446	0	0
Platelet Adhesion to exposed collagen	R-HSA-75892	3.583073e-01	0.446	0	0
Replication of the SARS-CoV-1 genome	R-HSA-9682706	3.583073e-01	0.446	0	0
G-protein beta:gamma signalling	R-HSA-397795	3.638434e-01	0.439	0	0
Nuclear RNA decay	R-HSA-9930044	3.638434e-01	0.439	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	3.638434e-01	0.439	0	0
Regulation of pyruvate metabolism	R-HSA-9861718	3.660850e-01	0.436	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	3.662901e-01	0.436	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	3.727661e-01	0.429	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	3.727661e-01	0.429	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	3.755330e-01	0.425	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	3.755330e-01	0.425	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	3.822033e-01	0.418	0	0
Formation of definitive endoderm	R-HSA-9823730	3.822033e-01	0.418	0	0
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	3.822033e-01	0.418	0	0
Protein-protein interactions at synapses	R-HSA-6794362	3.838249e-01	0.416	0	0
IRE1alpha activates chaperones	R-HSA-381070	3.885124e-01	0.411	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	3.919285e-01	0.407	0	0
CRMPs in Sema3A signaling	R-HSA-399956	3.919285e-01	0.407	0	0
Removal of the Flap Intermediate	R-HSA-69166	3.919285e-01	0.407	0	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	3.919285e-01	0.407	0	0
Malate-aspartate shuttle	R-HSA-9856872	3.919285e-01	0.407	0	0
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	3.919285e-01	0.407	0	0
Post-translational protein phosphorylation	R-HSA-8957275	3.927051e-01	0.406	0	0
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	3.941282e-01	0.404	0	0
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	3.941282e-01	0.404	0	0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)	R-HSA-5655799	3.941282e-01	0.404	0	0
Signaling by RAS GAP mutants	R-HSA-9753510	3.941282e-01	0.404	0	0
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	3.941282e-01	0.404	0	0
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	3.941282e-01	0.404	0	0
Potassium transport channels	R-HSA-1296067	3.941282e-01	0.404	0	0
Defective SLC12A1 causes Bartter syndrome 1 (BS1)	R-HSA-5619104	3.941282e-01	0.404	0	0
Defective AHCY causes HMAHCHD	R-HSA-5578997	3.941282e-01	0.404	0	0
mRNA Editing: A to I Conversion	R-HSA-75064	3.941282e-01	0.404	0	0
Signalling to ERK5	R-HSA-198765	3.941282e-01	0.404	0	0
C6 deamination of adenosine	R-HSA-75102	3.941282e-01	0.404	0	0
Interleukin-33 signaling	R-HSA-9014843	3.941282e-01	0.404	0	0
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	3.941282e-01	0.404	0	0
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	3.941282e-01	0.404	0	0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis	R-HSA-9708296	3.941282e-01	0.404	0	0
ATF6B (ATF6-beta) activates chaperones	R-HSA-8874177	3.941282e-01	0.404	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	3.972430e-01	0.401	0	0
Cristae formation	R-HSA-8949613	3.972430e-01	0.401	0	0
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	3.972430e-01	0.401	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	3.981392e-01	0.400	0	0
Activated NTRK2 signals through FYN	R-HSA-9032500	4.005300e-01	0.397	0	0
Activated NTRK2 signals through PI3K	R-HSA-9028335	4.005300e-01	0.397	0	0
Regulation by c-FLIP	R-HSA-3371378	4.005300e-01	0.397	0	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	4.005300e-01	0.397	0	0
Dimerization of procaspase-8	R-HSA-69416	4.005300e-01	0.397	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	4.005300e-01	0.397	0	0
Co-stimulation by ICOS	R-HSA-9927354	4.005300e-01	0.397	0	0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	4.005300e-01	0.397	0	0
Gluconeogenesis	R-HSA-70263	4.034272e-01	0.394	0	0
G-protein activation	R-HSA-202040	4.101154e-01	0.387	0	0
ERK/MAPK targets	R-HSA-198753	4.101154e-01	0.387	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	4.101154e-01	0.387	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	4.101154e-01	0.387	0	0
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	4.101154e-01	0.387	0	0
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	4.101154e-01	0.387	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	4.124892e-01	0.385	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	4.158133e-01	0.381	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	4.195303e-01	0.377	0	0
Erythropoietin activates RAS	R-HSA-9027284	4.250812e-01	0.372	0	0
G beta:gamma signalling through BTK	R-HSA-8964315	4.250812e-01	0.372	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	4.258814e-01	0.371	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	4.295671e-01	0.367	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	4.432656e-01	0.353	0	0
WNT mediated activation of DVL	R-HSA-201688	4.432656e-01	0.353	0	0
CASP8 activity is inhibited	R-HSA-5218900	4.432656e-01	0.353	0	0
Activation of the AP-1 family of transcription factors	R-HSA-450341	4.432656e-01	0.353	0	0
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	4.432656e-01	0.353	0	0
Respiratory syncytial virus genome replication	R-HSA-9834752	4.432656e-01	0.353	0	0
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	4.432656e-01	0.353	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	4.447310e-01	0.352	0	0
Signaling by Erythropoietin	R-HSA-9006335	4.458198e-01	0.351	0	0
Regulation of gene expression in beta cells	R-HSA-210745	4.458198e-01	0.351	0	0
Triglyceride catabolism	R-HSA-163560	4.515390e-01	0.345	0	0
GPVI-mediated activation cascade	R-HSA-114604	4.515390e-01	0.345	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	4.575808e-01	0.340	0	0
Activation of SMO	R-HSA-5635838	4.575808e-01	0.340	0	0
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	4.575808e-01	0.340	0	0
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	4.575808e-01	0.340	0	0
Killing mechanisms	R-HSA-9664420	4.575808e-01	0.340	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	4.602364e-01	0.337	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	4.650094e-01	0.333	0	0
FasL/ CD95L signaling	R-HSA-75157	4.654757e-01	0.332	0	0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	4.654757e-01	0.332	0	0
Axonal growth stimulation	R-HSA-209563	4.654757e-01	0.332	0	0
IRAK4 deficiency (TLR5)	R-HSA-5603037	4.654757e-01	0.332	1	1
MET activates PTPN11	R-HSA-8865999	4.654757e-01	0.332	0	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	4.654757e-01	0.332	0	0
Defective SLC7A7 causes lysinuric protein intolerance (LPI)	R-HSA-5660862	4.654757e-01	0.332	0	0
Defective ABCC2 causes DJS	R-HSA-5679001	4.654757e-01	0.332	0	0
Classical Kir channels	R-HSA-1296053	4.654757e-01	0.332	0	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	4.654757e-01	0.332	0	0
MET interacts with TNS proteins	R-HSA-8875513	4.654757e-01	0.332	0	0
Intracellular oxygen transport	R-HSA-8981607	4.654757e-01	0.332	0	0
Histamine receptors	R-HSA-390650	4.654757e-01	0.332	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	4.697539e-01	0.328	0	0
Toll-like Receptor Cascades	R-HSA-168898	4.719293e-01	0.326	1	0
Opioid Signalling	R-HSA-111885	4.725019e-01	0.326	0	0
Rab regulation of trafficking	R-HSA-9007101	4.746687e-01	0.324	0	0
Netrin-1 signaling	R-HSA-373752	4.757036e-01	0.323	0	0
Neuronal System	R-HSA-112316	4.789763e-01	0.320	0	0
Binding and entry of HIV virion	R-HSA-173107	4.842528e-01	0.315	0	0
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	4.842528e-01	0.315	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	4.842528e-01	0.315	0	0
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	4.842528e-01	0.315	0	0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	4.842528e-01	0.315	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	4.842528e-01	0.315	0	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	4.842528e-01	0.315	0	0
Disorders of transmembrane transporters	R-HSA-5619115	4.848209e-01	0.314	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	4.892725e-01	0.310	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	4.917756e-01	0.308	0	0
Downstream signal transduction	R-HSA-186763	4.933530e-01	0.307	0	0
Signaling by TGFBR3	R-HSA-9839373	5.147378e-01	0.288	0	0
RAS processing	R-HSA-9648002	5.155217e-01	0.288	0	0
Signaling by ALK	R-HSA-201556	5.155217e-01	0.288	0	0
Inwardly rectifying K+ channels	R-HSA-1296065	5.165519e-01	0.287	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	5.179657e-01	0.286	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	5.179657e-01	0.286	0	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	5.200292e-01	0.284	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	5.200292e-01	0.284	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	5.200292e-01	0.284	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	5.200292e-01	0.284	0	0
Replication of the SARS-CoV-2 genome	R-HSA-9694686	5.200292e-01	0.284	0	0
Gastrulation	R-HSA-9758941	5.222992e-01	0.282	0	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	5.233109e-01	0.281	0	0
RHOBTB3 ATPase cycle	R-HSA-9706019	5.233109e-01	0.281	0	0
Formation of the posterior neural plate	R-HSA-9832991	5.233109e-01	0.281	0	0
Chylomicron assembly	R-HSA-8963888	5.233109e-01	0.281	0	0
vRNP Assembly	R-HSA-192905	5.233109e-01	0.281	0	0
Alternative complement activation	R-HSA-173736	5.284250e-01	0.277	0	0
TNFR1-mediated ceramide production	R-HSA-5626978	5.284250e-01	0.277	0	0
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	5.284250e-01	0.277	0	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	5.284250e-01	0.277	0	0
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	5.284250e-01	0.277	0	0
Signaling by MAP2K mutants	R-HSA-9652169	5.284250e-01	0.277	0	0
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	5.284250e-01	0.277	0	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	5.284250e-01	0.277	0	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	5.284250e-01	0.277	0	0
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	5.284250e-01	0.277	0	0
Dopamine receptors	R-HSA-390651	5.284250e-01	0.277	0	0
AKT-mediated inactivation of FOXO1A	R-HSA-211163	5.284250e-01	0.277	0	0
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	5.284250e-01	0.277	0	0
Toxicity of tetanus toxin (tetX)	R-HSA-5250982	5.284250e-01	0.277	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	5.338656e-01	0.273	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	5.338656e-01	0.273	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	5.392922e-01	0.268	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	5.435036e-01	0.265	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	5.435036e-01	0.265	0	0
G protein gated Potassium channels	R-HSA-1296059	5.435036e-01	0.265	0	0
Activation of G protein gated Potassium channels	R-HSA-1296041	5.435036e-01	0.265	0	0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	5.435036e-01	0.265	0	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	5.435036e-01	0.265	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	5.470751e-01	0.262	0	0
G beta:gamma signalling through PLC beta	R-HSA-418217	5.497491e-01	0.260	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	5.497491e-01	0.260	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	5.497491e-01	0.260	0	0
Presynaptic function of Kainate receptors	R-HSA-500657	5.497491e-01	0.260	0	0
Tie2 Signaling	R-HSA-210993	5.497491e-01	0.260	0	0
Mismatch Repair	R-HSA-5358508	5.497491e-01	0.260	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	5.497491e-01	0.260	0	0
Metal ion SLC transporters	R-HSA-425410	5.526870e-01	0.258	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	5.572288e-01	0.254	0	0
Proton-coupled monocarboxylate transport	R-HSA-433692	5.603259e-01	0.252	0	0
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	5.603259e-01	0.252	0	0
Activation of RAC1	R-HSA-428540	5.603259e-01	0.252	0	0
Ca2+ pathway	R-HSA-4086398	5.605230e-01	0.251	0	0
Miscellaneous transport and binding events	R-HSA-5223345	5.615228e-01	0.251	0	0
TRP channels	R-HSA-3295583	5.683252e-01	0.245	0	0
Urea cycle	R-HSA-70635	5.683252e-01	0.245	0	0
Suppression of phagosomal maturation	R-HSA-9637687	5.683252e-01	0.245	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	5.764255e-01	0.239	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	5.783537e-01	0.238	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	5.783537e-01	0.238	0	0
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	5.783537e-01	0.238	0	0
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	5.783537e-01	0.238	0	0
O2/CO2 exchange in erythrocytes	R-HSA-1480926	5.783537e-01	0.238	0	0
Maturation of nucleoprotein	R-HSA-9694631	5.783537e-01	0.238	0	0
Pre-NOTCH Processing in Golgi	R-HSA-1912420	5.783537e-01	0.238	0	0
Other interleukin signaling	R-HSA-449836	5.783537e-01	0.238	0	0
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	5.783537e-01	0.238	0	0
Signal amplification	R-HSA-392518	5.831993e-01	0.234	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	5.831993e-01	0.234	0	0
Co-inhibition by BTLA	R-HSA-9927353	5.839641e-01	0.234	0	0
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	5.839641e-01	0.234	0	0
IRS activation	R-HSA-74713	5.839641e-01	0.234	0	0
G2 Phase	R-HSA-68911	5.839641e-01	0.234	0	0
NTRK2 activates RAC1	R-HSA-9032759	5.839641e-01	0.234	0	0
Defective SLC1A3 causes episodic ataxia 6 (EA6)	R-HSA-5619062	5.839641e-01	0.234	0	0
Activation of C3 and C5	R-HSA-174577	5.839641e-01	0.234	0	0
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	5.839641e-01	0.234	0	0
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	5.839641e-01	0.234	0	0
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	5.839641e-01	0.234	0	0
Muscarinic acetylcholine receptors	R-HSA-390648	5.839641e-01	0.234	0	0
Nectin/Necl trans heterodimerization	R-HSA-420597	5.839641e-01	0.234	0	0
Interleukin-36 pathway	R-HSA-9014826	5.839641e-01	0.234	0	0
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	5.839641e-01	0.234	0	0
Toxicity of botulinum toxin type G (botG)	R-HSA-5250989	5.839641e-01	0.234	0	0
Toxicity of botulinum toxin type C (botC)	R-HSA-5250971	5.839641e-01	0.234	0	0
Zinc efflux and compartmentalization by the SLC30 family	R-HSA-435368	5.839641e-01	0.234	0	0
Inositol phosphate metabolism	R-HSA-1483249	5.882921e-01	0.230	0	0
Iron uptake and transport	R-HSA-917937	5.909973e-01	0.228	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	5.923775e-01	0.227	0	0
Insulin processing	R-HSA-264876	5.923775e-01	0.227	0	0
ER Quality Control Compartment (ERQC)	R-HSA-901032	5.923775e-01	0.227	0	0
Serotonin clearance from the synaptic cleft	R-HSA-380615	5.952372e-01	0.225	0	0
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	5.952372e-01	0.225	0	0
GRB2 events in EGFR signaling	R-HSA-179812	5.952372e-01	0.225	0	0
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	5.952372e-01	0.225	0	0
Regulation of IFNG signaling	R-HSA-877312	5.952372e-01	0.225	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	5.958590e-01	0.225	0	0
Extension of Telomeres	R-HSA-180786	6.006985e-01	0.221	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	6.057848e-01	0.218	0	0
Formation of ATP by chemiosmotic coupling	R-HSA-163210	6.057848e-01	0.218	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	6.057848e-01	0.218	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	6.148077e-01	0.211	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	6.156181e-01	0.211	0	0
Inflammasomes	R-HSA-622312	6.156181e-01	0.211	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	6.176366e-01	0.209	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	6.245335e-01	0.204	0	0
RUNX2 regulates bone development	R-HSA-8941326	6.247449e-01	0.204	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	6.280269e-01	0.202	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	6.280269e-01	0.202	0	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	6.280269e-01	0.202	0	0
Processing of SMDT1	R-HSA-8949664	6.280269e-01	0.202	0	0
Interleukin-6 signaling	R-HSA-1059683	6.280269e-01	0.202	0	0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	6.280269e-01	0.202	0	0
Reversible hydration of carbon dioxide	R-HSA-1475029	6.280269e-01	0.202	0	0
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	6.320028e-01	0.199	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	6.320028e-01	0.199	0	0
Plus-strand DNA synthesis	R-HSA-164525	6.329651e-01	0.199	0	0
Nef Mediated CD8 Down-regulation	R-HSA-182218	6.329651e-01	0.199	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	6.329651e-01	0.199	0	0
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	6.329651e-01	0.199	0	0
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	6.329651e-01	0.199	0	0
Loss-of-function mutations in DBT cause MSUD2	R-HSA-9865113	6.329651e-01	0.199	0	0
Loss-of-function mutations in DLD cause MSUD3/DLDD	R-HSA-9907570	6.329651e-01	0.199	0	0
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	6.329651e-01	0.199	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	6.329651e-01	0.199	0	0
Phosphorylation of Emi1	R-HSA-176417	6.329651e-01	0.199	0	0
Ceramide signalling	R-HSA-193681	6.329651e-01	0.199	0	0
Signalling to p38 via RIT and RIN	R-HSA-187706	6.329651e-01	0.199	0	0
Acetylcholine inhibits contraction of outer hair cells	R-HSA-9667769	6.329651e-01	0.199	0	0
Orexin and neuropeptides FF and QRFP bind to their respective receptors	R-HSA-389397	6.329651e-01	0.199	0	0
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	6.329651e-01	0.199	0	0
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	6.329651e-01	0.199	0	0
PLC beta mediated events	R-HSA-112043	6.330762e-01	0.199	0	0
DAP12 interactions	R-HSA-2172127	6.332475e-01	0.198	0	0
Integrin cell surface interactions	R-HSA-216083	6.347814e-01	0.197	0	0
Integration of energy metabolism	R-HSA-163685	6.365654e-01	0.196	0	0
DARPP-32 events	R-HSA-180024	6.380140e-01	0.195	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	6.380140e-01	0.195	0	0
Innate Immune System	R-HSA-168249	6.404129e-01	0.194	1	0
Amino acids regulate mTORC1	R-HSA-9639288	6.412105e-01	0.193	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	6.445568e-01	0.191	0	0
Interferon alpha/beta signaling	R-HSA-909733	6.478175e-01	0.189	0	0
Mitochondrial protein import	R-HSA-1268020	6.487071e-01	0.188	0	0
Protein localization	R-HSA-9609507	6.506226e-01	0.187	0	0
Pyruvate metabolism	R-HSA-70268	6.559757e-01	0.183	0	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	6.569842e-01	0.182	1	1
Attachment and Entry	R-HSA-9694614	6.569842e-01	0.182	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	6.569842e-01	0.182	0	0
Ribavirin ADME	R-HSA-9755088	6.569842e-01	0.182	0	0
Retrograde neurotrophin signalling	R-HSA-177504	6.587105e-01	0.181	0	0
Zinc transporters	R-HSA-435354	6.587105e-01	0.181	0	0
Signal regulatory protein family interactions	R-HSA-391160	6.587105e-01	0.181	0	0
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	6.595416e-01	0.181	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	6.595416e-01	0.181	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	6.595416e-01	0.181	0	0
Interleukin-37 signaling	R-HSA-9008059	6.595416e-01	0.181	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	6.636993e-01	0.178	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	6.685226e-01	0.175	0	0
G alpha (z) signalling events	R-HSA-418597	6.736145e-01	0.172	0	0
Chylomicron clearance	R-HSA-8964026	6.761972e-01	0.170	0	0
Uncoating of the HIV Virion	R-HSA-162585	6.761972e-01	0.170	0	0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)	R-HSA-5619070	6.761972e-01	0.170	0	0
H139Hfs13* PPM1K causes a mild variant of MSUD	R-HSA-9912529	6.761972e-01	0.170	0	0
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	6.761972e-01	0.170	0	0
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	6.761972e-01	0.170	0	0
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	6.761972e-01	0.170	0	0
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	6.761972e-01	0.170	0	0
HDL clearance	R-HSA-8964011	6.761972e-01	0.170	0	0
VLDL assembly	R-HSA-8866423	6.761972e-01	0.170	0	0
Neurofascin interactions	R-HSA-447043	6.761972e-01	0.170	0	0
Molecules associated with elastic fibres	R-HSA-2129379	6.801851e-01	0.167	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	6.807192e-01	0.167	0	0
Notch-HLH transcription pathway	R-HSA-350054	6.807192e-01	0.167	0	0
LDL clearance	R-HSA-8964038	6.807192e-01	0.167	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	6.807192e-01	0.167	0	0
Neddylation	R-HSA-8951664	6.807997e-01	0.167	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	6.821577e-01	0.166	0	0
SHC1 events in EGFR signaling	R-HSA-180336	6.873292e-01	0.163	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	6.873292e-01	0.163	0	0
Formation of the anterior neural plate	R-HSA-9823739	6.873292e-01	0.163	0	0
Post-translational protein modification	R-HSA-597592	6.906209e-01	0.161	0	0
RSV-host interactions	R-HSA-9833110	6.924413e-01	0.160	0	0
Signaling by FGFR in disease	R-HSA-1226099	6.974714e-01	0.156	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	6.999220e-01	0.155	0	0
Interleukin-2 family signaling	R-HSA-451927	6.999220e-01	0.155	0	0
GPER1 signaling	R-HSA-9634597	7.015664e-01	0.154	0	0
NGF-stimulated transcription	R-HSA-9031628	7.015664e-01	0.154	0	0
Interleukin receptor SHC signaling	R-HSA-912526	7.032103e-01	0.153	0	0
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	7.032103e-01	0.153	0	0
Growth hormone receptor signaling	R-HSA-982772	7.032103e-01	0.153	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	7.139436e-01	0.146	0	0
Induction of Cell-Cell Fusion	R-HSA-9733458	7.139436e-01	0.146	0	0
Attachment and Entry	R-HSA-9678110	7.139436e-01	0.146	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	7.139436e-01	0.146	0	0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	7.139436e-01	0.146	0	0
Atorvastatin ADME	R-HSA-9754706	7.139436e-01	0.146	0	0
Differentiation of T cells	R-HSA-9945266	7.139436e-01	0.146	0	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	7.139436e-01	0.146	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	7.139436e-01	0.146	0	0
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	7.143394e-01	0.146	0	0
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	7.143394e-01	0.146	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	7.143394e-01	0.146	0	0
Activated NTRK2 signals through CDK5	R-HSA-9032845	7.143394e-01	0.146	0	0
LDL remodeling	R-HSA-8964041	7.143394e-01	0.146	0	0
Synthesis of PIPs in the nucleus	R-HSA-8847453	7.143394e-01	0.146	0	0
Netrin mediated repulsion signals	R-HSA-418886	7.143394e-01	0.146	0	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	7.143394e-01	0.146	0	0
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	7.143394e-01	0.146	0	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	7.169864e-01	0.144	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	7.172297e-01	0.144	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	7.186577e-01	0.143	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	7.187927e-01	0.143	0	0
G-protein mediated events	R-HSA-112040	7.208084e-01	0.142	0	0
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	7.244700e-01	0.140	0	0
Thromboxane signalling through TP receptor	R-HSA-428930	7.244700e-01	0.140	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	7.244700e-01	0.140	0	0
Plasma lipoprotein assembly	R-HSA-8963898	7.244700e-01	0.140	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	7.293954e-01	0.137	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	7.293954e-01	0.137	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	7.323150e-01	0.135	0	0
Peroxisomal protein import	R-HSA-9033241	7.326949e-01	0.135	0	0
Regulation of beta-cell development	R-HSA-186712	7.326949e-01	0.135	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	7.327645e-01	0.135	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	7.333493e-01	0.135	0	0
HIV Transcription Initiation	R-HSA-167161	7.333493e-01	0.135	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	7.333493e-01	0.135	0	0
Translation of Structural Proteins	R-HSA-9683701	7.333493e-01	0.135	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	7.358193e-01	0.133	0	0
Translation of Structural Proteins	R-HSA-9694635	7.358193e-01	0.133	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	7.367589e-01	0.133	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	7.367589e-01	0.133	0	0
tRNA processing	R-HSA-72306	7.378647e-01	0.132	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	7.386287e-01	0.132	0	0
Glycine degradation	R-HSA-6783984	7.386287e-01	0.132	0	0
Biosynthesis of maresin-like SPMs	R-HSA-9027307	7.386287e-01	0.132	0	0
Galactose catabolism	R-HSA-70370	7.386287e-01	0.132	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	7.386287e-01	0.132	0	0
Synthesis of PG	R-HSA-1483148	7.386287e-01	0.132	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	7.445195e-01	0.128	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	7.445195e-01	0.128	0	0
MicroRNA (miRNA) biogenesis	R-HSA-203927	7.445195e-01	0.128	0	0
Formation of the nephric duct	R-HSA-9830364	7.445195e-01	0.128	0	0
Hyaluronan degradation	R-HSA-2160916	7.445195e-01	0.128	0	0
Metabolism of polyamines	R-HSA-351202	7.462387e-01	0.127	0	0
The phototransduction cascade	R-HSA-2514856	7.468216e-01	0.127	0	0
Reverse Transcription of HIV RNA	R-HSA-162589	7.479905e-01	0.126	0	0
Minus-strand DNA synthesis	R-HSA-164516	7.479905e-01	0.126	0	0
RSK activation	R-HSA-444257	7.479905e-01	0.126	0	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	7.479905e-01	0.126	0	0
MET receptor recycling	R-HSA-8875656	7.479905e-01	0.126	0	0
Axonal growth inhibition (RHOA activation)	R-HSA-193634	7.479905e-01	0.126	0	0
Adrenoceptors	R-HSA-390696	7.479905e-01	0.126	0	0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	7.479905e-01	0.126	0	0
Activation of RAS in B cells	R-HSA-1169092	7.479905e-01	0.126	0	0
Fructose biosynthesis	R-HSA-5652227	7.479905e-01	0.126	0	0
Interleukin-9 signaling	R-HSA-8985947	7.479905e-01	0.126	0	0
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	7.479905e-01	0.126	0	0
SLC-mediated bile acid transport	R-HSA-9958517	7.479905e-01	0.126	0	0
TGFBR3 PTM regulation	R-HSA-9839383	7.479905e-01	0.126	0	0
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	7.479905e-01	0.126	0	0
Alpha-defensins	R-HSA-1462054	7.479905e-01	0.126	0	0
Sodium/Proton exchangers	R-HSA-425986	7.479905e-01	0.126	0	0
Toxicity of botulinum toxin type B (botB)	R-HSA-5250958	7.479905e-01	0.126	0	0
Interleukin-23 signaling	R-HSA-9020933	7.479905e-01	0.126	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	7.494710e-01	0.125	0	0
Mitochondrial protein degradation	R-HSA-9837999	7.514355e-01	0.124	0	0
eNOS activation	R-HSA-203615	7.538437e-01	0.123	0	0
Calnexin/calreticulin cycle	R-HSA-901042	7.538437e-01	0.123	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	7.538437e-01	0.123	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	7.607511e-01	0.119	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	7.614697e-01	0.118	0	0
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	7.614697e-01	0.118	0	0
Specification of primordial germ cells	R-HSA-9827857	7.614697e-01	0.118	0	0
MET activates PTK2 signaling	R-HSA-8874081	7.633867e-01	0.117	0	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	7.633867e-01	0.117	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	7.633867e-01	0.117	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	7.639824e-01	0.117	0	0
TBC/RABGAPs	R-HSA-8854214	7.639824e-01	0.117	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	7.700605e-01	0.113	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	7.700605e-01	0.113	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	7.718480e-01	0.112	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	7.718480e-01	0.112	0	0
Signaling by PDGF	R-HSA-186797	7.718480e-01	0.112	0	0
SLC transporter disorders	R-HSA-5619102	7.744465e-01	0.111	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	7.776793e-01	0.109	0	0
p75NTR regulates axonogenesis	R-HSA-193697	7.776793e-01	0.109	0	0
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	7.776793e-01	0.109	0	0
Interleukin-21 signaling	R-HSA-9020958	7.776793e-01	0.109	0	0
mRNA Editing	R-HSA-75072	7.776793e-01	0.109	0	0
Regulation of signaling by NODAL	R-HSA-1433617	7.776793e-01	0.109	0	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	7.776793e-01	0.109	0	0
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	7.776793e-01	0.109	0	0
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	7.776793e-01	0.109	0	0
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	7.776793e-01	0.109	0	0
Interferon gamma signaling	R-HSA-877300	7.795693e-01	0.108	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	7.811056e-01	0.107	0	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	7.822929e-01	0.107	0	0
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	7.825584e-01	0.106	0	0
Nephron development	R-HSA-9831926	7.825584e-01	0.106	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	7.854265e-01	0.105	0	0
RNA Polymerase III Transcription	R-HSA-74158	7.854265e-01	0.105	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	7.918745e-01	0.101	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	7.918745e-01	0.101	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	7.918745e-01	0.101	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	7.977143e-01	0.098	0	0
Formation of the Early Elongation Complex	R-HSA-113418	7.977143e-01	0.098	0	0
Pyroptosis	R-HSA-5620971	7.977143e-01	0.098	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	7.977143e-01	0.098	0	0
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	7.977143e-01	0.098	0	0
Regulation of insulin secretion	R-HSA-422356	8.010650e-01	0.096	0	0
Germ layer formation at gastrulation	R-HSA-9754189	8.019906e-01	0.096	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	8.019906e-01	0.096	0	0
Specification of the neural plate border	R-HSA-9834899	8.019906e-01	0.096	0	0
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	8.019906e-01	0.096	0	0
MAPK3 (ERK1) activation	R-HSA-110056	8.038720e-01	0.095	0	0
OADH complex synthesizes glutaryl-CoA from 2-OA	R-HSA-9858328	8.038720e-01	0.095	0	0
DNA replication initiation	R-HSA-68952	8.038720e-01	0.095	0	0
Metabolism of serotonin	R-HSA-380612	8.038720e-01	0.095	0	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	8.038720e-01	0.095	0	0
Signal attenuation	R-HSA-74749	8.038720e-01	0.095	0	0
Interleukin-27 signaling	R-HSA-9020956	8.038720e-01	0.095	0	0
Signaling by Leptin	R-HSA-2586552	8.038720e-01	0.095	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	8.048210e-01	0.094	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	8.048210e-01	0.094	0	0
Glucagon-type ligand receptors	R-HSA-420092	8.132546e-01	0.090	0	0
Elastic fibre formation	R-HSA-1566948	8.136901e-01	0.090	0	0
Signaling by NODAL	R-HSA-1181150	8.198638e-01	0.086	0	0
IRS-mediated signalling	R-HSA-112399	8.219490e-01	0.085	0	0
Pentose phosphate pathway	R-HSA-71336	8.266357e-01	0.083	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	8.266357e-01	0.083	0	0
Leishmania phagocytosis	R-HSA-9664417	8.267443e-01	0.083	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	8.267443e-01	0.083	0	0
Parasite infection	R-HSA-9664407	8.267443e-01	0.083	0	0
vRNA Synthesis	R-HSA-192814	8.269802e-01	0.083	0	0
Activated NTRK3 signals through RAS	R-HSA-9034864	8.269802e-01	0.083	0	0
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	8.269802e-01	0.083	0	0
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	8.269802e-01	0.083	0	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	8.269802e-01	0.083	0	0
Interleukin-2 signaling	R-HSA-9020558	8.269802e-01	0.083	0	0
Dissolution of Fibrin Clot	R-HSA-75205	8.269802e-01	0.083	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	8.274367e-01	0.082	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	8.277706e-01	0.082	0	0
Neurotransmitter clearance	R-HSA-112311	8.277706e-01	0.082	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	8.287888e-01	0.082	0	0
Mitochondrial biogenesis	R-HSA-1592230	8.335998e-01	0.079	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	8.336630e-01	0.079	0	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	8.362756e-01	0.078	0	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	8.362756e-01	0.078	0	0
Diseases of Immune System	R-HSA-5260271	8.388259e-01	0.076	1	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	8.388259e-01	0.076	1	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.413083e-01	0.075	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	8.426637e-01	0.074	0	0
Triglyceride metabolism	R-HSA-8979227	8.426637e-01	0.074	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	8.444903e-01	0.073	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	8.451341e-01	0.073	0	0
Synthesis of diphthamide-EEF2	R-HSA-5358493	8.473669e-01	0.072	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	8.473669e-01	0.072	0	0
Plasmalogen biosynthesis	R-HSA-75896	8.473669e-01	0.072	0	0
ERKs are inactivated	R-HSA-202670	8.473669e-01	0.072	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	8.473669e-01	0.072	0	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	8.473669e-01	0.072	0	0
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	8.473669e-01	0.072	0	0
Activated NTRK2 signals through RAS	R-HSA-9026519	8.473669e-01	0.072	0	0
Azathioprine ADME	R-HSA-9748787	8.503067e-01	0.070	0	0
PI3K Cascade	R-HSA-109704	8.503067e-01	0.070	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	8.513221e-01	0.070	0	0
FRS-mediated FGFR3 signaling	R-HSA-5654706	8.513221e-01	0.070	0	0
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	8.513221e-01	0.070	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	8.539145e-01	0.069	0	0
Intra-Golgi traffic	R-HSA-6811438	8.610527e-01	0.065	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	8.610527e-01	0.065	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	8.613790e-01	0.065	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	8.650972e-01	0.063	0	0
FRS-mediated FGFR4 signaling	R-HSA-5654712	8.650972e-01	0.063	0	0
RAF-independent MAPK1/3 activation	R-HSA-112409	8.650972e-01	0.063	0	0
Fructose metabolism	R-HSA-5652084	8.650972e-01	0.063	0	0
Neurotoxicity of clostridium toxins	R-HSA-168799	8.650972e-01	0.063	0	0
Regulation of IFNA/IFNB signaling	R-HSA-912694	8.650972e-01	0.063	0	0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	8.650972e-01	0.063	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	8.653525e-01	0.063	0	0
Defective EXT2 causes exostoses 2	R-HSA-3656237	8.653525e-01	0.063	0	0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	R-HSA-3656253	8.653525e-01	0.063	0	0
Maple Syrup Urine Disease	R-HSA-9865114	8.653525e-01	0.063	0	0
Interleukin-35 Signalling	R-HSA-8984722	8.653525e-01	0.063	0	0
MET activates RAS signaling	R-HSA-8851805	8.653525e-01	0.063	0	0
Trafficking and processing of endosomal TLR	R-HSA-1679131	8.653525e-01	0.063	0	0
SHC-related events triggered by IGF1R	R-HSA-2428933	8.653525e-01	0.063	0	0
OAS antiviral response	R-HSA-8983711	8.653525e-01	0.063	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	8.656364e-01	0.063	0	0
Heme signaling	R-HSA-9707616	8.700239e-01	0.060	0	0
Activation of GABAB receptors	R-HSA-991365	8.711480e-01	0.060	0	0
GABA B receptor activation	R-HSA-977444	8.711480e-01	0.060	0	0
Glutamate and glutamine metabolism	R-HSA-8964539	8.765215e-01	0.057	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	8.765215e-01	0.057	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	8.775126e-01	0.057	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	8.776915e-01	0.057	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	8.776915e-01	0.057	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	8.776915e-01	0.057	0	0
Formation of the ureteric bud	R-HSA-9830674	8.776915e-01	0.057	0	0
Biosynthesis of maresins	R-HSA-9018682	8.776915e-01	0.057	0	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	8.776915e-01	0.057	0	0
Nucleotide biosynthesis	R-HSA-8956320	8.783316e-01	0.056	0	0
Diseases of carbohydrate metabolism	R-HSA-5663084	8.794049e-01	0.056	0	0
OGDH complex synthesizes succinyl-CoA from 2-OG	R-HSA-9853506	8.812197e-01	0.055	0	0
Chylomicron remodeling	R-HSA-8963901	8.812197e-01	0.055	0	0
PDH complex synthesizes acetyl-CoA from PYR	R-HSA-9861559	8.812197e-01	0.055	0	0
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	8.812197e-01	0.055	0	0
Maturation of nucleoprotein	R-HSA-9683610	8.812197e-01	0.055	0	0
Insulin receptor signalling cascade	R-HSA-74751	8.859666e-01	0.053	0	0
IGF1R signaling cascade	R-HSA-2428924	8.859666e-01	0.053	0	0
Hyaluronan metabolism	R-HSA-2142845	8.866163e-01	0.052	0	0
Interleukin-6 family signaling	R-HSA-6783589	8.891919e-01	0.051	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	8.891919e-01	0.051	0	0
TNFs bind their physiological receptors	R-HSA-5669034	8.891919e-01	0.051	0	0
Amine ligand-binding receptors	R-HSA-375280	8.894516e-01	0.051	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	8.932966e-01	0.049	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	8.935389e-01	0.049	0	0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV	R-HSA-9859138	8.952179e-01	0.048	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	8.952179e-01	0.048	0	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	8.952179e-01	0.048	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	8.952179e-01	0.048	0	0
cGMP effects	R-HSA-418457	8.952179e-01	0.048	0	0
Formation of the active cofactor, UDP-glucuronate	R-HSA-173599	8.952179e-01	0.048	0	0
Physiological factors	R-HSA-5578768	8.952179e-01	0.048	0	0
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.952179e-01	0.048	0	0
HDL assembly	R-HSA-8963896	8.952179e-01	0.048	0	0
P2Y receptors	R-HSA-417957	8.952179e-01	0.048	0	0
Transferrin endocytosis and recycling	R-HSA-917977	8.959667e-01	0.048	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	8.977196e-01	0.047	0	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	8.996813e-01	0.046	0	0
Laminin interactions	R-HSA-3000157	8.996813e-01	0.046	0	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	8.996813e-01	0.046	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.012506e-01	0.045	0	0
Kidney development	R-HSA-9830369	9.067556e-01	0.043	0	0
Protein lipoylation	R-HSA-9857492	9.075671e-01	0.042	0	0
Signaling by Activin	R-HSA-1502540	9.075671e-01	0.042	0	0
Protein repair	R-HSA-5676934	9.075671e-01	0.042	0	0
Dopamine clearance from the synaptic cleft	R-HSA-379401	9.075671e-01	0.042	0	0
Lysosphingolipid and LPA receptors	R-HSA-419408	9.075671e-01	0.042	0	0
Other semaphorin interactions	R-HSA-416700	9.075671e-01	0.042	0	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	9.075671e-01	0.042	0	0
Synthesis of PA	R-HSA-1483166	9.086412e-01	0.042	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	9.092382e-01	0.041	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.092382e-01	0.041	0	0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.179367e-01	0.037	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	9.182869e-01	0.037	0	0
Defective GALNT3 causes HFTC	R-HSA-5083625	9.184615e-01	0.037	0	0
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	9.184615e-01	0.037	0	0
Defective GALNT12 causes CRCS1	R-HSA-5083636	9.184615e-01	0.037	0	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	9.184615e-01	0.037	0	0
Class I peroxisomal membrane protein import	R-HSA-9603798	9.184615e-01	0.037	0	0
Phase 4 - resting membrane potential	R-HSA-5576886	9.184615e-01	0.037	0	0
Fructose catabolism	R-HSA-70350	9.184615e-01	0.037	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	9.199927e-01	0.036	0	0
Adipogenesis	R-HSA-9843745	9.234337e-01	0.035	0	0
Telomere Extension By Telomerase	R-HSA-171319	9.258462e-01	0.033	0	0
FRS-mediated FGFR2 signaling	R-HSA-5654700	9.258462e-01	0.033	0	0
Insulin receptor recycling	R-HSA-77387	9.258462e-01	0.033	0	0
Prednisone ADME	R-HSA-9757110	9.258462e-01	0.033	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	9.278054e-01	0.033	0	0
Defective B4GALT7 causes EDS, progeroid type	R-HSA-3560783	9.280725e-01	0.032	0	0
Defective B3GALT6 causes EDSP2 and SEMDJL1	R-HSA-4420332	9.280725e-01	0.032	0	0
Fibronectin matrix formation	R-HSA-1566977	9.280725e-01	0.032	0	0
Heme assimilation	R-HSA-9927020	9.280725e-01	0.032	0	0
Transcriptional regulation of testis differentiation	R-HSA-9690406	9.280725e-01	0.032	0	0
Passive transport by Aquaporins	R-HSA-432047	9.280725e-01	0.032	0	0
tRNA modification in the mitochondrion	R-HSA-6787450	9.280725e-01	0.032	0	0
Coenzyme A biosynthesis	R-HSA-196783	9.280725e-01	0.032	0	0
Aquaporin-mediated transport	R-HSA-445717	9.321245e-01	0.031	0	0
mRNA Capping	R-HSA-72086	9.330319e-01	0.030	0	0
Defective B3GAT3 causes JDSSDHD	R-HSA-3560801	9.365511e-01	0.028	0	0
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	9.365511e-01	0.028	0	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	9.365511e-01	0.028	0	0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	9.365511e-01	0.028	0	0
Choline catabolism	R-HSA-6798163	9.365511e-01	0.028	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	9.365511e-01	0.028	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	9.395546e-01	0.027	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.395546e-01	0.027	0	0
Signaling by Insulin receptor	R-HSA-74752	9.399075e-01	0.027	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	9.417102e-01	0.026	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	9.417736e-01	0.026	0	0
PI Metabolism	R-HSA-1483255	9.430933e-01	0.025	0	0
PKA activation	R-HSA-163615	9.440307e-01	0.025	0	0
PKA activation in glucagon signalling	R-HSA-164378	9.440307e-01	0.025	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	9.440307e-01	0.025	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	9.440307e-01	0.025	0	0
Nucleotide-like (purinergic) receptors	R-HSA-418038	9.440307e-01	0.025	0	0
Vitamin D (calciferol) metabolism	R-HSA-196791	9.440307e-01	0.025	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.441506e-01	0.025	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	9.490282e-01	0.023	0	0
HDL remodeling	R-HSA-8964058	9.506289e-01	0.022	0	0
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	9.506289e-01	0.022	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.520133e-01	0.021	0	0
Cardiogenesis	R-HSA-9733709	9.556879e-01	0.020	0	0
Wax and plasmalogen biosynthesis	R-HSA-8848584	9.564496e-01	0.019	0	0
Creatine metabolism	R-HSA-71288	9.564496e-01	0.019	0	0
Common Pathway of Fibrin Clot Formation	R-HSA-140875	9.564496e-01	0.019	0	0
Pregnenolone biosynthesis	R-HSA-196108	9.564496e-01	0.019	0	0
Potassium Channels	R-HSA-1296071	9.567911e-01	0.019	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	9.574316e-01	0.019	0	0
Leishmania infection	R-HSA-9658195	9.584964e-01	0.018	0	0
Parasitic Infection Pathways	R-HSA-9824443	9.584964e-01	0.018	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.600825e-01	0.018	0	0
Heme degradation	R-HSA-189483	9.600825e-01	0.018	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	9.604897e-01	0.018	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	9.615844e-01	0.017	0	0
SHC-mediated cascade:FGFR3	R-HSA-5654704	9.615844e-01	0.017	0	0
Phenylalanine metabolism	R-HSA-8964208	9.615844e-01	0.017	0	0
Vitamin C (ascorbate) metabolism	R-HSA-196836	9.615844e-01	0.017	0	0
Neurotransmitter release cycle	R-HSA-112310	9.638222e-01	0.016	0	0
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.640572e-01	0.016	0	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.640572e-01	0.016	0	0
RA biosynthesis pathway	R-HSA-5365859	9.640572e-01	0.016	0	0
SHC-mediated cascade:FGFR4	R-HSA-5654719	9.661141e-01	0.015	0	0
Molybdenum cofactor biosynthesis	R-HSA-947581	9.661141e-01	0.015	0	0
Serine metabolism	R-HSA-977347	9.661141e-01	0.015	0	0
COPII-mediated vesicle transport	R-HSA-204005	9.663862e-01	0.015	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	9.664879e-01	0.015	0	0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	R-HSA-193775	9.676498e-01	0.014	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	9.701098e-01	0.013	0	0
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.701098e-01	0.013	0	0
Ethanol oxidation	R-HSA-71384	9.701098e-01	0.013	0	0
RAB geranylgeranylation	R-HSA-8873719	9.704913e-01	0.013	0	0
tRNA Aminoacylation	R-HSA-379724	9.704913e-01	0.013	0	0
GABA receptor activation	R-HSA-977443	9.704913e-01	0.013	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.704913e-01	0.013	0	0
Cytoprotection by HMOX1	R-HSA-9707564	9.708217e-01	0.013	0	0
Glycosphingolipid transport	R-HSA-9845576	9.708952e-01	0.013	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	9.708952e-01	0.013	0	0
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.735156e-01	0.012	0	0
Chemokine receptors bind chemokines	R-HSA-380108	9.735156e-01	0.012	0	0
Termination of O-glycan biosynthesis	R-HSA-977068	9.736346e-01	0.012	0	0
Interleukin-20 family signaling	R-HSA-8854691	9.736346e-01	0.012	0	0
Aspirin ADME	R-HSA-9749641	9.736544e-01	0.012	0	0
Metabolism of folate and pterines	R-HSA-196757	9.738253e-01	0.012	0	0
tRNA processing in the mitochondrion	R-HSA-6785470	9.764694e-01	0.010	0	0
CYP2E1 reactions	R-HSA-211999	9.767439e-01	0.010	0	0
SHC-mediated cascade:FGFR1	R-HSA-5654688	9.767439e-01	0.010	0	0
Mitochondrial RNA degradation	R-HSA-9836573	9.767439e-01	0.010	0	0
Complex III assembly	R-HSA-9865881	9.767439e-01	0.010	0	0
Acyl chain remodelling of PS	R-HSA-1482801	9.794867e-01	0.009	0	0
Beta-oxidation of pristanoyl-CoA	R-HSA-389887	9.794867e-01	0.009	0	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	9.794867e-01	0.009	0	0
rRNA processing in the mitochondrion	R-HSA-8868766	9.810036e-01	0.008	0	0
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.810036e-01	0.008	0	0
Tryptophan catabolism	R-HSA-71240	9.810036e-01	0.008	0	0
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	9.819062e-01	0.008	0	0
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.819062e-01	0.008	0	0
Sphingolipid catabolism	R-HSA-9845614	9.819062e-01	0.008	0	0
Maturation of spike protein	R-HSA-9694548	9.829405e-01	0.007	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	9.840404e-01	0.007	0	0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	R-HSA-83936	9.840404e-01	0.007	0	0
SHC-mediated cascade:FGFR2	R-HSA-5654699	9.840404e-01	0.007	0	0
Maturation of hRSV A proteins	R-HSA-9828806	9.840404e-01	0.007	0	0
Extracellular matrix organization	R-HSA-1474244	9.840515e-01	0.007	0	0
Scavenging by Class A Receptors	R-HSA-3000480	9.846849e-01	0.007	0	0
Paracetamol ADME	R-HSA-9753281	9.851625e-01	0.006	0	0
Thyroxine biosynthesis	R-HSA-209968	9.875836e-01	0.005	0	0
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.875836e-01	0.005	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.875836e-01	0.005	0	0
Dectin-2 family	R-HSA-5621480	9.878079e-01	0.005	0	0
Transport of small molecules	R-HSA-382551	9.884171e-01	0.005	0	0
Surfactant metabolism	R-HSA-5683826	9.889395e-01	0.005	0	0
Retinoid metabolism and transport	R-HSA-975634	9.889788e-01	0.005	0	0
ECM proteoglycans	R-HSA-3000178	9.889788e-01	0.005	0	0
Formation of the cornified envelope	R-HSA-6809371	9.895443e-01	0.005	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.899965e-01	0.004	0	0
Aspartate and asparagine metabolism	R-HSA-8963693	9.903405e-01	0.004	0	0
Cargo concentration in the ER	R-HSA-5694530	9.903405e-01	0.004	0	0
Signaling by Retinoic Acid	R-HSA-5362517	9.909435e-01	0.004	0	0
HS-GAG degradation	R-HSA-2024096	9.914802e-01	0.004	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.916465e-01	0.004	0	0
Collagen degradation	R-HSA-1442490	9.918037e-01	0.004	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	9.919086e-01	0.004	0	0
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.924855e-01	0.003	0	0
Recycling of bile acids and salts	R-HSA-159418	9.924855e-01	0.003	0	0
Plasma lipoprotein remodeling	R-HSA-8963899	9.928617e-01	0.003	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	9.933722e-01	0.003	0	0
Acyl chain remodelling of PC	R-HSA-1482788	9.933722e-01	0.003	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.937113e-01	0.003	0	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.941543e-01	0.003	0	0
Interleukin-10 signaling	R-HSA-6783783	9.942560e-01	0.003	0	0
Class B/2 (Secretin family receptors)	R-HSA-373080	9.943680e-01	0.002	0	0
Acyl chain remodelling of PE	R-HSA-1482839	9.948442e-01	0.002	0	0
Metabolism of ingested SeMet, Sec, MeSec into H2Se	R-HSA-2408508	9.948442e-01	0.002	0	0
Branched-chain amino acid catabolism	R-HSA-70895	9.948738e-01	0.002	0	0
Complex IV assembly	R-HSA-9864848	9.948738e-01	0.002	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.950479e-01	0.002	0	0
HS-GAG biosynthesis	R-HSA-2022928	9.954527e-01	0.002	0	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.954527e-01	0.002	0	0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.955267e-01	0.002	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.956778e-01	0.002	0	0
Voltage gated Potassium channels	R-HSA-1296072	9.959894e-01	0.002	0	0
Lysine catabolism	R-HSA-71064	9.959894e-01	0.002	0	0
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.959894e-01	0.002	0	0
Phenylalanine and tyrosine metabolism	R-HSA-8963691	9.959894e-01	0.002	0	0
Collagen chain trimerization	R-HSA-8948216	9.959894e-01	0.002	0	0
FCGR activation	R-HSA-2029481	9.960668e-01	0.002	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.960668e-01	0.002	0	0
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.964628e-01	0.002	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.967085e-01	0.001	0	0
Visual phototransduction	R-HSA-2187338	9.967451e-01	0.001	0	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.968803e-01	0.001	0	0
G alpha (q) signalling events	R-HSA-416476	9.969117e-01	0.001	0	0
Peptide hormone metabolism	R-HSA-2980736	9.970240e-01	0.001	0	0
Aflatoxin activation and detoxification	R-HSA-5423646	9.975734e-01	0.001	0	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.981126e-01	0.001	0	0
FCERI mediated MAPK activation	R-HSA-2871796	9.981279e-01	0.001	0	0
Defensins	R-HSA-1461973	9.983355e-01	0.001	0	0
Pyrimidine catabolism	R-HSA-73621	9.983355e-01	0.001	0	0
Synthesis of very long-chain fatty acyl-CoAs	R-HSA-75876	9.983355e-01	0.001	0	0
Methylation	R-HSA-156581	9.985320e-01	0.001	0	0
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.985320e-01	0.001	0	0
SLC-mediated transport of organic anions	R-HSA-9955298	9.985643e-01	0.001	0	0
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.987054e-01	0.001	0	0
Degradation of cysteine and homocysteine	R-HSA-1614558	9.987054e-01	0.001	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.988025e-01	0.001	0	0
Xenobiotics	R-HSA-211981	9.988057e-01	0.001	0	0
G alpha (s) signalling events	R-HSA-418555	9.988335e-01	0.001	0	0
Asparagine N-linked glycosylation	R-HSA-446203	9.988345e-01	0.001	0	0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.989931e-01	0.000	0	0
Synthesis of PC	R-HSA-1483191	9.989931e-01	0.000	0	0
Collagen formation	R-HSA-1474290	9.989976e-01	0.000	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.992417e-01	0.000	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.992568e-01	0.000	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.993055e-01	0.000	0	0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.993094e-01	0.000	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.993100e-01	0.000	0	0
Bile acid and bile salt metabolism	R-HSA-194068	9.993295e-01	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	9.994104e-01	0.000	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.994216e-01	0.000	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.994501e-01	0.000	0	0
Metabolism of cofactors	R-HSA-8978934	9.994615e-01	0.000	0	0
Metabolism of porphyrins	R-HSA-189445	9.994615e-01	0.000	0	0
Glucuronidation	R-HSA-156588	9.995824e-01	0.000	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.996007e-01	0.000	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.996114e-01	0.000	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.996114e-01	0.000	0	0
Citric acid cycle (TCA cycle)	R-HSA-71403	9.996595e-01	0.000	0	0
Metabolism of amine-derived hormones	R-HSA-209776	9.996752e-01	0.000	0	0
PPARA activates gene expression	R-HSA-1989781	9.997649e-01	0.000	0	0
Heparan sulfate/heparin (HS-GAG) metabolism	R-HSA-1638091	9.997773e-01	0.000	0	0
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.998295e-01	0.000	0	0
Complex I biogenesis	R-HSA-6799198	9.998654e-01	0.000	0	0
CD22 mediated BCR regulation	R-HSA-5690714	9.998813e-01	0.000	0	0
Sulfur amino acid metabolism	R-HSA-1614635	9.999149e-01	0.000	0	0
Metabolism of steroid hormones	R-HSA-196071	9.999186e-01	0.000	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.999218e-01	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	9.999271e-01	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999275e-01	0.000	0	0
O-linked glycosylation of mucins	R-HSA-913709	9.999282e-01	0.000	0	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.999508e-01	0.000	0	0
Metal ion assimilation from the host	R-HSA-9638482	9.999508e-01	0.000	0	0
Purine catabolism	R-HSA-74259	9.999566e-01	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	9.999566e-01	0.000	0	0
Transport of vitamins, nucleosides, and related molecules	R-HSA-425397	9.999663e-01	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999698e-01	0.000	0	0
Drug ADME	R-HSA-9748784	9.999770e-01	0.000	0	0
Cholesterol biosynthesis	R-HSA-191273	9.999796e-01	0.000	0	0
G alpha (i) signalling events	R-HSA-418594	9.999818e-01	0.000	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.999820e-01	0.000	0	0
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.999820e-01	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999821e-01	0.000	0	0
GPCR downstream signalling	R-HSA-388396	9.999856e-01	0.000	0	0
Peroxisomal lipid metabolism	R-HSA-390918	9.999904e-01	0.000	0	0
Respiratory electron transport	R-HSA-611105	9.999928e-01	0.000	0	0
Phospholipid metabolism	R-HSA-1483257	9.999934e-01	0.000	0	0
Keratinization	R-HSA-6805567	9.999936e-01	0.000	0	0
Nucleotide catabolism	R-HSA-8956319	9.999975e-01	0.000	0	0
Scavenging of heme from plasma	R-HSA-2168880	9.999984e-01	0.000	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999994e-01	0.000	0	0
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999995e-01	0.000	0	0
Signaling by GPCR	R-HSA-372790	9.999996e-01	0.000	0	0
Antimicrobial peptides	R-HSA-6803157	9.999998e-01	0.000	0	0
Initial triggering of complement	R-HSA-166663	9.999999e-01	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	9.999999e-01	0.000	0	0
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000e+00	0.000	0	0
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	1.000000e+00	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	1.000000e+00	0.000	0	0
Regulation of Complement cascade	R-HSA-977606	1.000000e+00	0.000	0	0
Metabolism of steroids	R-HSA-8957322	1.000000e+00	0.000	0	0
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000	0	0
Sensory perception of taste	R-HSA-9717189	1.000000e+00	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	1.000000e+00	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000	0	0
O-linked glycosylation	R-HSA-5173105	1.000000e+00	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000	0	0
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000	0	0
Complement cascade	R-HSA-166658	1.000000e+00	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000	0	0
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000	0	0
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000	0	0
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000	0	0
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	-0.000	0	0