PIM3

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
A5A3E0 Y940 Sugiyama POTEF A26C1B ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
O00488 S93 Sugiyama ZNF593 ZT86 STNLKTHFRSKDHKKRLKQLsVEPysQEEAERAAGMGSYVP
O14617 S658 Sugiyama AP3D1 PRO0039 DERPRAVFHEEEQRRPKHRPsEADEEELARRREARKQEQAN
O14618 S267 Sugiyama CCS DGLTIWEERGRPIAGKGRKEsAQPPAHL_____________
O14732 S160 Sugiyama IMPA2 IMP.18P RLYTGRRGRGAFCNGQRLRVsGETDLSKALVLTEIGPKRDP
O15067 S215 Sugiyama PFAS KIAA0361 LDSWDLDFYTKRFQELQRNPstVEAFDLAQsNsEHSRHWFF
O60271 S183 Sugiyama SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6 HTEMIHNYMEHLERTKLHQLsGsDQLEstAHsRIRKERPIs
O60271 S190 Sugiyama SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6 YMEHLERTKLHQLsGsDQLEstAHsRIRKERPIsLGIFPLP
O60271 S194 Sugiyama SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6 LERTKLHQLsGsDQLEstAHsRIRKERPIsLGIFPLPAGDG
O60293 S42 Sugiyama ZFC3H1 CCDC131 KIAA0546 PSRC2 LEDGEIsDDDNNSQIRSRsssSsSGGGLLPYPRRRPPHSAR
O60343 S751 Sugiyama TBC1D4 AS160 KIAA0603 EIRQDTASESSDGEGRKRtSstCsNEsLsVGGTSVTPRRIS
O60343 S754 Sugiyama TBC1D4 AS160 KIAA0603 QDTASESSDGEGRKRtSstCsNEsLsVGGTSVTPRRISWRQ
O60343 T749 Sugiyama TBC1D4 AS160 KIAA0603 ENEIRQDTASESSDGEGRKRtSstCsNEsLsVGGTSVTPRR
O60664 S175 Sugiyama PLIN3 M6PRBP1 TIP47 RGAVQSGVDKTKsVVtGGVQsVMGsRLGQMVLsGVDtVLGK
O60664 S93 Sugiyama PLIN3 M6PRBP1 TIP47 AAVsGAQPILSKLEPQIAsAsEyAHRGLDKLEENLPILQQP
O60814 S37 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
O60814 Y38 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK AVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
O60841 S182 Sugiyama EIF5B IF2 KIAA0741 DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O60841 S183 Sugiyama EIF5B IF2 KIAA0741 GsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKN
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O75534 T761 Sugiyama CSDE1 D1S155E KIAA0885 NRU UNR GPKAVAAPRPDRLVNRLKNItLDDAsAPRLMVLRQPRGPDN
O94761 S27 Sugiyama RECQL4 RECQ4 VRERLQAWERAFRRQRGRRPsQDDVEAAPEETRALYREYRT
O95155 S23 Sugiyama UBE4B HDNB1 KIAA0684 UFD2 ELSADEIRRRRLARLAGGQtsQPttPLtsPQRENPPGPPIA
O95639 S267 Sugiyama CPSF4 CPSF30 NAR NEB1 KCGEKGHYANRCTKGHLAFLsGQ__________________
O95678 S162 Sugiyama KRT75 K6HF KB18 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
O95831 S116 Sugiyama AIFM1 AIF PDCD8 NERIsGLGLtPEQKQKKAALsAsEGEEVPQDKAPSHVPFLL
P00338 S105 Sugiyama LDHA PIG19 VTANsKLVIItAGARQQEGEsRLNLVQRNVNIFKFIIPNVV
P00338 S161 PSP|Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00338 S167 Sugiyama LDHA PIG19 AWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVHPLSCHG
P00338 S319 PSP LDHA PIG19 GISDLVKVTLtsEEEARLKKsADtLWGIQKELQF_______
P00491 S163 Sugiyama PNP NP GQNPLRGPNDERFGDRFPAMsDAyDRtMRQRALstWKQMGE
P00491 S176 Sugiyama PNP NP GDRFPAMsDAyDRtMRQRALstWKQMGEQRELQEGTYVMVA
P00558 S174 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 LSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKEL
P00558 S175 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 SKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKELN
P00558 S393 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 GGDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDA
P00558 T394 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 GDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDAL
P00558 Y161 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 KAEPAKIEAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNL
P01106 S308 PSP MYC BHLHE39 PGKRSESGSPSAGGHSKPPHsPLVLKRCHVSTHQHNYAAPP
P02538 S176 Sugiyama KRT6A K6A KRT6D IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P02545 S12 Sugiyama LMNA LMN1 _________METPsQRRAtRsGAQAsstPLsPtRItRLQEK
P02545 S458 Sugiyama LMNA LMN1 GRVAVEEVDEEGKFVRLRNKsNEDQsMGNWQIKRQNGDDPL
P02545 T10 Sugiyama LMNA LMN1 ___________METPsQRRAtRsGAQAsstPLsPtRItRLQ
P04040 T28 Sugiyama CAT ASDQMQHWKEQRAAQKADVLttGAGNPVGDKLNVItVGPRG
P04040 T29 Sugiyama CAT SDQMQHWKEQRAAQKADVLttGAGNPVGDKLNVItVGPRGP
P04075 S336 Sugiyama ALDOA ALDA GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075 S346 Sugiyama ALDOA ALDA EEYVKRALANsLACQGKytPsGQAGAAAsEsLFVsNHAy__
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S360 Sugiyama ALDOA ALDA QGKytPsGQAGAAAsEsLFVsNHAy________________
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04075 T65 Sugiyama ALDOA ALDA QsIGtENtEENRRFyRQLLLtADDRVNPCIGGVILFHETLY
P04083 S173 Sugiyama ANXA1 ANX1 LPC1 NRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRsEDFG
P04259 S176 Sugiyama KRT6B K6B KRTL1 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406 S210 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 GPsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtG
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 S25 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 KVGVNGFGRIGRLVtRAAFNsGKVDIVAINDPFIDLNyMVY
P04406 T19 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 __MGKVKVGVNGFGRIGRLVtRAAFNsGKVDIVAINDPFID
P04406 T211 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 PsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtGM
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04792 S83 Sugiyama HSPB1 HSP27 HSP28 IEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNH
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05455 S325 Sugiyama SSB VLEGEVEKEALKKIIEDQQEsLNKWKSKGRRFKGKGKGNKA
P05787 S104 Sugiyama KRT8 CYK8 IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P05787 S291 Sugiyama KRT8 CYK8 ANRsRAEAEsMyQIKyEELQsLAGKHGDDLRRTKTEISEMN
P05787 S475 Sugiyama KRT8 CYK8 TSSSRAVVVKKIETRDGKLVsEssDVLPK____________
P06733 S27 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P06733 S37 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 NPtVEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRY
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06744 T109 Sugiyama GPI KINyTEGRAVLHVALRNRsNtPILVDGKDVMPEVNKVLDKM
P06899 S37 Sugiyama H2BC11 H2BFR HIST1H2BJ KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISS
P07195 S106 Sugiyama LDHB VtANSKIVVVtAGVRQQEGEsRLNLVQRNVNVFKFIIPQIV
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 S168 Sugiyama LDHB TWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIHPSSCHG
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195 T302 Sugiyama LDHB YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07205 S393 Sugiyama PGK2 PGKB GGDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEA
P07205 T394 Sugiyama PGK2 PGKB GDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEAL
P07205 Y161 Sugiyama PGK2 PGKB KAEPDKIEAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNL
P07437 T55 Sugiyama TUBB TUBB5 OK/SW-cl.56 tyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEPGtMDs
P07737 S133 Sugiyama PFN1 LMGKEGVHGGLINKKCyEMAsHLRRsQY_____________
P07814 S335 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 PIEKNLQMWEEMKKGsQFGQsCCLRAKIDMSSNNGCMRDPt
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07864 S167 Sugiyama LDHC LDH3 LDHX VWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVHPTSCHG
P07900 S165 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGTK
P07900 S391 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MDNCEELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P07900 S470 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA HEDsQNRKKLsELLRyytsAsGDEMVsLKDYCTRMKENQKH
P07900 S50 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MSLIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKL
P07900 S52 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900 S63 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPN
P07900 T467 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LGIHEDsQNRKKLsELLRyytsAsGDEMVsLKDYCTRMKEN
P07900 Y284 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DEEEEKKDGDKKKKKKIKEKyIDQEELNKtKPIWtRNPDDI
P07900 Y466 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA KLGIHEDsQNRKKLsELLRyytsAsGDEMVsLKDYCTRMKE
P08195 S296 Sugiyama SLC3A2 MDU1 DLLQIDPNFGsKEDFDsLLQsAKKKSIRVILDLTPNYRGEN
P08238 S160 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB AEKVVVITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGTK
P08238 S383 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MDSCDELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P08238 S45 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 S48 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08238 S497 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB KEtQKsIyyItGEsKEQVANsAFVERVRKRGFEVVyMtEPI
P08238 S58 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPN
P08238 T487 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB tsLsEyVsRMKEtQKsIyyItGEsKEQVANsAFVERVRKRG
P08238 Y276 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DEEDDsGKDKKKKTKKIKEKyIDQEELNKtKPIWtRNPDDI
P08729 S104 Sugiyama KRT7 SCL LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P08758 T10 Sugiyama ANXA5 ANX5 ENX2 PP4 ___________MAQVLRGtVtDFPGFDERADAEtLRKAMKG
P08865 T94 Sugiyama RPSA LAMBR LAMR1 VsVIssRNtGQRAVLKFAAAtGAtPIAGRFtPGTFTNQIQA
P09661 S226 Sugiyama SNRPA1 NAIANAstLAEVERLKGLLQsGQIPGRERRsGPtDDGEEEM
P09874 S274 Sugiyama PARP1 ADPRT PPOL KVCstNDLKELLIFNKQQVPsGEsAILDRVADGMVFGALLP
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG47 S57 Sugiyama UBB PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0CG48 S57 Sugiyama UBC PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P10412 S36 Sugiyama H1-4 H1F4 HIST1H1E EKtPVKKKARKsAGAAKRKAsGPPVsELItKAVAASKERsG
P10809 T422 Sugiyama HSPD1 HSP60 AVLKVGGtsDVEVNEKKDRVtDALNAtRAAVEEGIVLGGGC
P11142 S340 Sugiyama HSPA8 HSC70 HSP73 HSPA10 ALRDAKLDKsQIHDIVLVGGstRIPKIQKLLQDFFNGKELN
P11142 T47 Sugiyama HSPA8 HSC70 HSP73 HSPA10 EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtNtV
P11142 Y41 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P11586 T128 Sugiyama MTHFD1 MTHFC MTHFD SINTEEVINAIAPEKDVDGLtsINAGKLARGDLNDCFIPCt
P11940 T379 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 AtKPLyVALAQRKEERQAHLtNQyMQRMASVRAVPNPVINP
P12004 S172 Sugiyama PCNA sHIGDAVVIsCAKDGVKFSAsGELGNGNIKLSQTSNVDKEE
P12035 S211 Sugiyama KRT3 IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P12268 S432 Sugiyama IMPDH2 IMPD2 RGMGsLDAMDKHLssQNRyFsEADKIKVAQGVsGAVQDKGS
P12277 S129 Sugiyama CKB CKBB DLNPDNLQGGDDLDPNyVLssRVRTGRSIRGFCLPPHCsRG
P13489 S178 Sugiyama RNH1 PRI RNH SCEPLASVLRAKPDFKELtVsNNDINEAGVRVLCQGLKDSP
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 S584 Sugiyama EEF2 EF2 DHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyM
P13639 S593 Sugiyama EEF2 EF2 SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13647 S181 Sugiyama KRT5 IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13674 S387 Sugiyama P4HA1 P4HA NPITGDLETVHYRISKsAWLsGyENPVVsRINMRIQDLTGL
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14314 T469 Sugiyama PRKCSH G19P1 WGsWIGPDHDKFSAMKyEQGtGCWQGPNRstTVRLLCGKEt
P14618 S202 Sugiyama PKM OIP3 PK2 PK3 PKM2 SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs
P14618 S67 Sugiyama PKM OIP3 PK2 PK3 PKM2 IICtIGPAsRsVEtLKEMIKsGMNVARLNFsHGtHEyHAEt
P14625 S106 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625 S109 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P14625 S514 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK
P14625 S515 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 GVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQ
P14625 S551 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MKEKQDKIyFMAGsSRKEAEssPFVERLLKKGyEVIyLTEP
P14625 S680 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 RIMKAQAYQtGKDIstNyyAsQKKTFEINPRHPLIRDMLRR
P14625 T519 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 DHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQDKIy
P14866 S291 Sugiyama HNRNPL HNRPL P/OKcl.14 TRLNVFKNDQDtWDyTNPNLsGQGDPGsNPNKRQRQPPLLG
P14866 S544 Sugiyama HNRNPL HNRPL P/OKcl.14 LGVKRPSSVKVFSGKsERsssGLLEWEsKSDALETLGFLNH
P15311 S535 Sugiyama EZR VIL2 EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15880 S206 Sugiyama RPS2 RPS4 GRCGsVLVRLIPAPRGtGIVsAPVPKKLLMMAGIDDCytsA
P16402 S37 Sugiyama H1-3 H1F3 HIST1H1D KtPVKKKAKKAGATAGKRKAsGPPVsELItKAVAASKERsG
P16403 S36 Sugiyama H1-2 H1F2 HIST1H1C EKAPVKKKAAKKAGGtPRKAsGPPVsELItKAVAASKERsG
P17066 T49 Sugiyama HSPA6 HSP70B' EILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHNtV
P17066 Y43 Sugiyama HSPA6 HSP70B' FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P17655 S462 Sugiyama CAPN2 CANPL2 GQTNIHLSKNFFLTNRARERsDtFINLREVLNRFKLPPGEY
P17987 S551 Sugiyama TCP1 CCT1 CCTA IKLHPESKDDKHGsyEDAVHsGALND_______________
P18206 S820 Sugiyama VCL DAKAVAGNIsDPGLQKsFLDsGyRILGAVAKVREAFQPQEP
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19338 S619 Sugiyama NCL RIVTDRETGssKGFGFVDFNsEEDAKAAKEAMEDGEIDGNK
P20618 S157 Sugiyama PSMB1 PSC5 IIGGLDEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLL
P21108 S10 Sugiyama PRPS1L1 PRPS3 PRPSL ___________MPNIKIFsGssHQDLSQKIADRLGLELGKV
P21108 S8 Sugiyama PRPS1L1 PRPS3 PRPSL _____________MPNIKIFsGssHQDLSQKIADRLGLELG
P21333 S1301 Sugiyama FLNA FLN FLN1 DARALtQtGGPHVKARVANPsGNLTEtyVQDRGDGMYKVEy
P22033 S481 Sugiyama MMUT MUT EGIPKLRIEECAARRQARIDsGSEVIVGVNKYQLEKEDAVE
P22059 S379 Sugiyama OSBP OSBP1 FFDAPEIITMPENLGHKRtGsNIsGAssDIsLDEQyKHQLE
P22314 S1020 Sugiyama UBA1 A1S9T UBE1 FFMPAAKLKERLDQPMtEIVsRVSKRKLGRHVRALVLELCC
P22626 S225 Sugiyama HNRNPA2B1 HNRPA2B1 GNFGFGDsRGGGGNFGPGPGsNFRGGsDGyGsGRGFGDGyN
P22626 Y347 Sugiyama HNRNPA2B1 HNRPA2B1 MGGPyGGGNyGPGGsGGsGGyGGRsRy______________
P23381 S378 Sugiyama WARS1 IFI53 WARS WRS sIFLtDtAKQIKTKVNKHAFsGGRDtIEEHRQFGGNCDVDV
P23396 T70 Sugiyama RPS3 OK/SW-cl.26 ILATRTQNVLGEKGRRIRELtAVVQKRFGFPEGsVELyAEK
P23527 S37 Sugiyama H2BC17 H2BFH H2BFN HIST1H2BO KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISS
P24752 S218 Sugiyama ACAT1 ACAT MAT ENTAKKLNIARNEQDAyAINsytRSKAAWEAGKFGNEVIPV
P25789 S7 Sugiyama PSMA4 HC9 PSC9 ______________MSRRyDsRttIFsPEGRLYQVEYAMEA
P26038 S144 Sugiyama MSN LLASyAVQSKYGDFNKEVHKsGYLAGDKLLPQRVLEQHKLN
P26038 S527 Sugiyama MSN ERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHAE
P26373 S106 Sugiyama RPL13 BBC1 OK/SW-cl.46 IHKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLIL
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373 S97 Sugiyama RPL13 BBC1 OK/SW-cl.46 sLEELRVAGIHKKVARTIGIsVDPRRRNKstEsLQANVQRL
P26373 T107 Sugiyama RPL13 BBC1 OK/SW-cl.46 HKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILF
P26639 S39 Sugiyama TARS1 TARS PIGAGEEKQKEGGKKKNKEGsGDGGRAELNPWPEyIytRLE
P26641 S25 Sugiyama EEF1G EF1G PRO1608 TLyTyPENWRAFKALIAAQYsGAQVRVLsAPPHFHFGQtNR
P27348 S45 Sugiyama YWHAQ CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27708 S1859 Sugiyama CAD RGIPGLPDGRFHLPPRIHRAsDPGLPAEEPKEKSSRKVAEP
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P29401 S105 Sugiyama TKT VWAEAGFLAEAELLNLRKIssDLDGHPVPKQAFtDVATGsL
P29401 S332 Sugiyama TKT GDKIATRKAYGQALAKLGHAsDRIIALDGDtKNstFsEIFK
P29401 S473 Sugiyama TKT AtEKAVELAANTKGICFIRTsRPENAIIyNNNEDFQVGQAK
P30041 T49 Sugiyama PRDX6 AOP2 KIAA0106 LGDSWGILFSHPRDFtPVCttELGRAAKLAPEFAKRNVKLI
P30043 S198 Sugiyama BLVRB FLR SCAN KHDLGHFMLRCLttDEyDGHstyPsHQyQ____________
P30050 S157 Sugiyama RPL12 QsVGCNVDGRHPHDIIDDINsGAVECPAs____________
P30086 S142 Sugiyama PEBP1 PBP PEBP WLVyEQDRPLKCDEPILsNRsGDHRGKFKVAsFRKKyELRA
P30101 S98 Sugiyama PDIA3 ERP57 ERP60 GRP58 VPLAKVDCTANTNTCNKyGVsGyPtLKIFRDGEEAGAyDGP
P30533 S242 Sugiyama LRPAP1 A2MRAP TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P30533 T248 Sugiyama LRPAP1 A2MRAP LRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWDLAQSAN
P30533 Y246 Sugiyama LRPAP1 A2MRAP EKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWDLAQS
P30876 S882 Sugiyama POLR2B GDDVIIGKTVtLPENEDELEstNRRYTKRDCSTFLRTSETG
P31327 S819 Sugiyama CPS1 MAIGRTFEEsFQKALRMCHPsIEGFTPRLPMNKEWPsNLDL
P31943 S269 Sugiyama HNRNPH1 HNRPH HNRPH1 YNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGstFQsttGH
P31946 S132 Sugiyama YWHAB TQPESKVFyLKMKGDYFRyLsEVAsGDNKQTtVsNsQQAyQ
P31946 S47 Sugiyama YWHAB AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947 S45 Sugiyama SFN HME1 FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P32119 T142 Sugiyama PRDX2 NKEFB TDPX1 EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P32929 S56 Sugiyama CTH AVVPPISLSTTFKQGAPGQHsGFEysRsGNPTRNCLEKAVA
P33316 S120 Sugiyama DUT PsKRARPAEVGGMQLRFARLsEHAtAPTRGsARAAGYDLYS
P33778 S37 Sugiyama H2BC3 H2BFF HIST1H2BB KAITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISS
P34931 T49 Sugiyama HSPA1L EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQNTV
P34931 Y43 Sugiyama HSPA1L FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P34932 S76 Sugiyama HSPA4 APG2 HSPH2 VISNAKNTVQGFKRFHGRAFsDPFVEAEKSNLAYDIVQLPT
P35269 T156 Sugiyama GTF2F1 RAP74 EAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHFSI
P35568 S1101 EPSD|PSP IRS1 RNQSAKVIRADPQGCRRRHssEtFsstPSATRVGNTVPFGA
P35613 S279 Sugiyama BSG UNQ6505/PRO21383 TDSEDKALMNGSESRFFVsssQGRSELHIENLNMEADPGQy
P35908 S191 Sugiyama KRT2 KRT2A KRT2E IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P36578 S87 Sugiyama RPL4 RPL1 WGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAPTKT
P36578 T84 Sugiyama RPL4 RPL1 AEsWGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAP
P36871 S483 Sugiyama PGM1 DKVYtVEKADNFEysDPVDGsIsRNQGLRLIFTDGSRIVFR
P37802 S145 Sugiyama TAGLN2 KIAA0120 CDABP0035 VQRTLMNLGGLAVARDDGLFsGDPNWFPKKSKENPRNFsDN
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37837 S13 Sugiyama TALDO1 TAL TALDO TALDOR ________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P38606 S125 Sugiyama ATP6V1A ATP6A1 ATP6V1A1 VPP2 PLSDISSQTQSIYIPRGVNVsALSRDIKWDFTPCKNLRVGS
P38646 S212 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 tVPAyFNDsQRQAtKDAGQIsGLNVLRVINEPTAAALAyGL
P38646 T120 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P38646 T398 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39023 S265 Sugiyama RPL3 OK/SW-cl.32 HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P40227 S49 Sugiyama CCT6A CCT6 CCTZ GLQDVLRTNLGPKGTMKMLVsGAGDIKLTKDGNVLLHEMQI
P40429 S44 Sugiyama RPL13A AKQVLLGRKVVVVRCEGINIsGNFyRNKLKYLAFLRKRMNt
P40818 S719 Sugiyama USP8 KIAA0055 UBPY KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P40925 S153 Sugiyama MDH1 MDHA ANtNCLtAsKSAPSIPKENFsCLtRLDHNRAKAQIALKLGV
P40939 T418 Sugiyama HADHA HADH DRGQQQVFKGLNDKVKKKALtSFERDSIFSNLTGQLDyQGF
P41091 S282 Sugiyama EIF2S3 EIF2G FDVNKPGCEVDDLKGGVAGGsILKGVLKVGQEIEVRPGIVS
P42677 S78 Sugiyama RPS27 MPS1 GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P43034 S152 Sugiyama PAFAH1B1 LIS1 MDCR MDS PAFAHA IKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADM
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46013 S299 Sugiyama MKI67 GLQGETQLLVSRKSRPKsGGsGHAVAEPAsPEQELDQNKGK
P46013 S648 Sugiyama MKI67 RVSISRsQHDILQMICSKRRsGAsEANLIVAKSWADVVKLG
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777 S176 Sugiyama RPL5 MSTP030 GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P47756 S192 Sugiyama CAPZB TVMLWLQTNKSGsGtMNLGGsLtRQMEKDEtVsDCsPHIAN
P48668 S176 Sugiyama KRT6C KRT6E IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P48741 T49 Sugiyama HSPA7 HSP70B EILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHNtV
P48741 Y43 Sugiyama HSPA7 HSP70B FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P49321 S662 Sugiyama NASP LKELLPEIREKIEDAKEsQRsGNVAELALKATLVEsstsGF
P49327 S1997 Sugiyama FASN FAS DGLLENQTPEFFQDVCKPKYsGtLNLDRVTREACPELDYFV
P49327 S265 Sugiyama FASN FAS TILNAGTNTDGFKEQGVtFPsGDIQEQLIRSLyQsAGVAPE
P49368 T430 Sugiyama CCT3 CCTG TRIC5 GGGASEMAVAHALTEKSKAMtGVEQWPyRAVAQALEVIPRT
P49368 T459 Sugiyama CCT3 CCTG TRIC5 AVAQALEVIPRTLIQNCGAstIRLLtSLRAKHtQENCEtWG
P49419 S84 Sugiyama ALDH7A1 ATQ1 EVIttyCPANNEPIARVRQAsVADyEEtVKKAREAWKIWAD
P50502 S181 Sugiyama ST13 AAG2 FAM10A1 HIP SNC6 LQKPNAAIRDCDRAIEINPDsAQPyKWRGKAHRLLGHWEEA
P50990 S23 Sugiyama CCT8 C21orf112 CCTQ KIAA0002 LHVPKAPGFAQMLKEGAKHFsGLEEAVyRNIQACKELAQTT
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51116 S603 Sugiyama FXR2 FMR1L2 QRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQsR
P51116 Y614 Sugiyama FXR2 FMR1L2 RGNRtDGsIsGDRQPVtVADyIsRAEsQsRQRPPLERTKPs
P51692 S731 PSP STAT5B FVNASADAGGGSATyMDQAPsPAVCPQAHyNMyPQNPDSVL
P52209 S126 Sugiyama PGD PGDH YRDTTRRCRDLKAKGILFVGsGVsGGEEGARyGPSLMPGGN
P52209 S129 Sugiyama PGD PGDH TTRRCRDLKAKGILFVGsGVsGGEEGARyGPSLMPGGNKEA
P53365 S260 Sugiyama ARFIP2 POR1 TDLEELsLGPRDAGTRGRLEsAQATFQAHRDKYEKLRGDVA
P53999 S118 Sugiyama SUB1 PC4 RPO2TC1 PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P53999 S56 Sugiyama SUB1 PC4 RPO2TC1 PVKKQKTGETsRALsssKQssssRDDNMFQIGKMRYVSVRD
P54652 T48 Sugiyama HSPA2 EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTNTI
P54652 Y42 Sugiyama HSPA2 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P55072 S718 Sugiyama VCP HEL-220 HEL-S-70 AIREsIEsEIRRERERQtNPsAMEVEEDDPVPEIRRDHFEE
P55735 S184 Sugiyama SEC13 D3S1231E SEC13A SEC13L1 SEC13R PGsLIDHPSGQKPNYIKRFAsGGCDNLIKLWKEEEDGQWKE
P55795 S269 Sugiyama HNRNPH2 FTP3 HNRPH2 YNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGssFQstTGH
P57053 S37 Sugiyama H2BC12L H2BFS H2BS1 KAVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIss
P57053 Y38 Sugiyama H2BC12L H2BFS H2BS1 AVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssK
P57721 S59 Sugiyama PCBP3 PCBP3-OT1 PCBP3OT EGGLNVTLTIRLLMHGKEVGsIIGKKGETVKKMREESGARI
P57721 S82 Sugiyama PCBP3 PCBP3-OT1 PCBP3OT GKKGETVKKMREESGARINIsEGNCPERIVTITGPTDAIFK
P57721 T159 Sugiyama PCBP3 PCBP3-OT1 PCBP3OT sQCGsLIGKGGSKIKEIREstGAQVQVAGDMLPNstERAVT
P57723 S31 Sugiyama PCBP4 EPELSITLTLRMLMHGKEVGsIIGKKGETVKRIREQSSARI
P58876 S37 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
P58876 Y38 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD AVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60174 T214 Sugiyama TPI1 TPI KsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGG
P60174 T217 Sugiyama TPI1 TPI VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60228 S442 Sugiyama EIF3E EIF3S6 INT6 IEKKLNQNSRSEAPNWAtQDsGFy_________________
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 T202 Sugiyama ACTB GRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVALD
P60709 Y240 Sugiyama ACTB ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P60842 T80 Sugiyama EIF4A1 DDX2A EIF4A QRAILPCIKGyDVIAQAQsGtGKTATFAISILQQIELDLKA
P60891 S10 Sugiyama PRPS1 ___________MPNIKIFsGssHQDLSQKIADRLGLELGKV
P60891 S8 Sugiyama PRPS1 _____________MPNIKIFsGssHQDLSQKIADRLGLELG
P61221 Y594 Sugiyama ABCE1 RLI RNASEL1 RNASELI RNS4I OK/SW-cl.40 RPRINKLNsIKDVEQKKsGNyFFLDD_______________
P61254 S23 Sugiyama RPL26 FNPFVtsDRsKNRKRHFNAPsHIRRKIMssPLSKELRQKYN
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61769 T106 Sugiyama B2M CDABP0092 HDCMA22P YYTEFTPTEKDEYACRVNHVtLsQPKIVKWDRDM_______
P61978 S401 Sugiyama HNRNPK HNRPK GDLGGPIIttQVtIPKDLAGsIIGKGGQRIKQIRHEsGAsI
P61978 S417 Sugiyama HNRNPK HNRPK DLAGsIIGKGGQRIKQIRHEsGAsIKIDEPLEGsEDRIITI
P61978 S420 Sugiyama HNRNPK HNRPK GsIIGKGGQRIKQIRHEsGAsIKIDEPLEGsEDRIITItGt
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981 S46 Sugiyama YWHAG AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P61981 T31 Sugiyama YWHAG ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62258 S46 Sugiyama YWHAE SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62263 S114 Sugiyama RPS14 PRO2640 HIKLRATGGNRtKtPGPGAQsALRALARSGMKIGRIEDVtP
P62263 S137 Sugiyama RPS14 PRO2640 RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62263 S139 Sugiyama RPS14 PRO2640 LARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL________
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280 S74 Sugiyama RPS11 tyIDKKCPFTGNVsIRGRILsGVVTKMKMQRTIVIRRDYLH
P62280 T15 Sugiyama RPS11 ______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62280 T28 Sugiyama RPS11 RAyQKQPtIFQNKKRVLLGEtGKEKLPRYYKNIGLGFKtPK
P62736 Y242 Sugiyama ACTA2 ACTSA ACTVS GIG46 ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62750 Y144 Sugiyama RPL23A VNtLIRPDGEKKAYVRLAPDyDALDVANKIGII________
P62753 S148 Sugiyama RPS6 OK/SW-cl.2 tVPRRLGPKRASRIRKLFNLsKEDDVRQyVVRKPLNKEGKK
P62753 S53 Sugiyama RPS6 OK/SW-cl.2 AtEVAADALGEEWKGYVVRIsGGNDKQGFPMKQGVLTHGRV
P62805 S48 Sugiyama H4C1 H4/A H4FA HIST1H4A; H4C2 H4/I H4FI HIST1H4B; H4C3 H4/G H4FG HIST1H4C; H4C4 H4/B H4FB HIST1H4D; H4C5 H4/J H4FJ HIST1H4E; H4C6 H4/C H4FC HIST1H4F; H4C8 H4/H H4FH HIST1H4H; H4C9 H4/M H4FM HIST1H4I; H4C11 H4/E H4FE HIST1H4J; H4C12 H4/D H4FD HIST1H4K; H4C13 H4/K H4FK HIST1H4L; H4C14 H4/N H4F2 H4FN HIST2H4 HIST2H4A; H4C15 H4/O H4FO HIST2H4B; H4C16 H4-16 HIST4H4 QGItKPAIRRLARRGGVKRIsGLIyEETRGVLKVFLENVIR
P62807 S37 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI KAVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIss
P62807 Y38 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI AVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssK
P62826 T32 Sugiyama RAN ARA24 OK/SW-cl.81 KLVLVGDGGtGKttFVKRHLtGEFEKKyVATLGVEVHPLVF
P62826 T66 Sugiyama RAN ARA24 OK/SW-cl.81 EVHPLVFHTNRGPIKFNVWDtAGQEKFGGLRDGYYIQAQCA
P62826 Y146 Sugiyama RAN ARA24 OK/SW-cl.81 IKDRKVKAKsIVFHRKKNLQyyDIsAKSNyNFEKPFLWLAR
P62851 S74 Sugiyama RPS25 tyDKLCKEVPNYKLItPAVVsERLKIRGSLARAALQELLsK
P62888 S75 Sugiyama RPL30 LRKsEIEyyAMLAKtGVHHysGNNIELGtACGKyyRVCtLA
P62899 S15 Sugiyama RPL31 ______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62910 S105 Sugiyama RPL32 PP9932 LEVLLMCNKsyCAEIAHNVSsKNRKAIVERAAQLAIRVTNP
P62913 S51 Sugiyama RPL11 DRLtRAAKVLEQLtGQtPVFsKARyTVRsFGIRRNEKIAVH
P62913 T44 Sugiyama RPL11 ICVGEsGDRLtRAAKVLEQLtGQtPVFsKARyTVRsFGIRR
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 S138 Sugiyama RPL8 EKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVI
P62917 S14 Sugiyama RPL8 _______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62979 S123 Sugiyama RPS27A UBA80 UBCEP1 LKYYKVDENGKIsRLRRECPsDECGAGVFMAsHFDRHyCGK
P62979 S57 Sugiyama RPS27A UBA80 UBCEP1 PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGA
P62987 S57 Sugiyama UBA52 UBCEP2 PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGI
P63104 S45 Sugiyama YWHAZ CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 T202 Sugiyama ACTG1 ACTG GRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVALD
P63261 Y240 Sugiyama ACTG1 ACTG ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63267 Y241 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P67809 S136 Sugiyama YBX1 NSEP1 YB1 GEKGAEAANVtGPGGVPVQGsKYAADRNHYRRYPRRRGPPR
P67809 S209 Sugiyama YBX1 NSEP1 YB1 RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P67809 T126 Sugiyama YBX1 NSEP1 YB1 GEtVEFDVVEGEKGAEAANVtGPGGVPVQGsKYAADRNHYR
P67809 Y99 Sugiyama YBX1 NSEP1 YB1 DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
P68032 Y242 Sugiyama ACTC1 ACTC ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68104 T432 Sugiyama EEF1A1 EEF1A EF1A LENG7 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133 Y242 Sugiyama ACTA1 ACTA ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P68431 T59 Sugiyama H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J PHRyRPGtVALREIRRYQKstELLIRKLPFQRLVREIAQDF
P78371 S143 Sugiyama CCT2 99D8.1 CCTB PQTIIAGWREATKAAREALLssAVDHGsDEVKFRQDLMNIA
P78371 S144 Sugiyama CCT2 99D8.1 CCTB QTIIAGWREATKAAREALLssAVDHGsDEVKFRQDLMNIAG
P84098 S37 Sugiyama RPL19 CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
P84243 T59 Sugiyama H3-3A H3.3A H3F3 H3F3A PP781; H3-3B H3.3B H3F3B PHRyRPGtVALREIRRYQKstELLIRKLPFQRLVREIAQDF
Q00610 S146 Sugiyama CLTC CLH17 CLTCL2 KIAA0034 AVYHWSMEGESQPVKMFDRHssLAGCQIINYRTDAKQKWLL
Q01105 S161 Sugiyama SET FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q01105 S165 Sugiyama SET PyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQ
Q01546 S196 Sugiyama KRT76 KRT2B KRT2P IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q02543 S123 Sugiyama RPL18A AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK
Q04446 T570 Sugiyama GBE1 DFPRKGNNESYHYARRQFHLtDDDLLRYKFLNNFDRDMNRL
Q04695 S32 Sugiyama KRT17 SsIKGSSGLGGGsSRTsCRLsGGLGAGsCRLGSAGGLGSTL
Q04726 S197 Sugiyama TLE3 KIAA1547 HLTVKDEKNHHELDHREREssANNsVsPsEsLRAsEKHRGs
Q04917 S46 Sugiyama YWHAH YWHA1 AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q05639 T432 Sugiyama EEF1A2 EEF1AL STN VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q06830 T143 Sugiyama PRDX1 PAGA PAGB TDPX2 EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q06830 Y116 Sugiyama PRDX1 PAGA PAGB TDPX2 GLGPMNIPLVSDPKRtIAQDyGVLKADEGIsFRGLFIIDDK
Q07021 S106 Sugiyama C1QBP GC1QBP HABP1 SF2P32 LsDEIKEERKIQKHKTLPKMsGGWELELNGTEAKLVRKVAG
Q08J23 S593 Sugiyama NSUN2 SAKI TRM4 NNSEKMKVINTGIKVWCRNNsGEEFDCAFRLAQEGIYTLYP
Q09028 S147 Sugiyama RBBP4 RBAP48 VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC
Q09028 S159 Sugiyama RBBP4 RBAP48 IIATKtPssDVLVFDyTKHPsKPDPsGECNPDLRLRGHQKE
Q09028 S164 Sugiyama RBBP4 RBAP48 tPssDVLVFDyTKHPsKPDPsGECNPDLRLRGHQKEGYGLS
Q09161 S22 Sugiyama NCBP1 CBP80 NCBP SRRRHsDENDGGQPHKRRKtsDANEtEDHLEsLICKVGEKS
Q13200 S361 SIGNOR|PSP PSMD2 TRAP2 EPKVPDDIyKtHLENNRFGGsGsQVDSARMNLASSFVNGFV
Q13263 S473 Sugiyama TRIM28 KAP1 RNF96 TIF1B sGDDPyssAEPHVsGVKRsRsGEGEVsGLMRKVPRVsLERL
Q13263 S479 Sugiyama TRIM28 KAP1 RNF96 TIF1B ssAEPHVsGVKRsRsGEGEVsGLMRKVPRVsLERLDLDLtA
Q13442 S19 Sugiyama PDAP1 HASPP28 __MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEEE
Q13442 T18 Sugiyama PDAP1 HASPP28 ___MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEE
Q13561 Y86 Sugiyama DCTN2 DCTN50 GLDFsDRIGKTKRtGyEsGEyEMLGEGLGVKETPQQKYQRL
Q14152 S1256 Sugiyama EIF3A EIF3S10 KIAA0139 EDRFRRPRDEGGWRRGPAEEsssWRDssRRDDRDRDDRRRE
Q14152 S215 Sugiyama EIF3A EIF3S10 KIAA0139 RKLCDNLRMHLsQIQRHHNQstAINLNNPESQsMHLETRLV
Q14152 S584 Sugiyama EIF3A EIF3S10 KIAA0139 EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14240 T81 Sugiyama EIF4A2 DDX2B EIF4F QRAIIPCIKGyDVIAQAQsGtGKTATFAISILQQLEIEFKE
Q14566 S271 Sugiyama MCM6 VPDVSKLSTPGARAEtNsRVsGVDGyEtEGIRGLRALGVRD
Q14566 T195 Sugiyama MCM6 TQPNICRNPVCANRRRFLLDtNKSRFVDFQKVRIQETQAEL
Q14568 S165 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGTK
Q14568 S50 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 MSLIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKL
Q14568 S52 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14568 Y283 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 sDEEEEKKDGDKKKKKTKEKyIDQEELNKTKPIWTRNPDDI
Q14671 T112 Sugiyama PUM1 KIAA0099 PUMH1 QLGGGGsGGGGyNNsKHRWPtGDNIHAEHQVRsMDELNHDF
Q14697 S45 Sugiyama GANAB G2AN KIAA0088 VCLGITLAVDRSNFKtCEEssFCKRQRsIRPGLsPyRALLD
Q14697 T40 Sugiyama GANAB G2AN KIAA0088 LAFLGVCLGITLAVDRSNFKtCEEssFCKRQRsIRPGLsPy
Q14CN4 S138 Sugiyama KRT72 K6IRS2 KB35 KRT6 KRT6IRS2 IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15056 S13 Sugiyama EIF4H KIAA0038 WBSCR1 WSCR1 ________MADFDtyDDRAyssFGGGRGsRGsAGGHGsRSQ
Q15185 S72 Sugiyama PTGES3 P23 TEBP EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE
Q15293 Y278 Sugiyama RCN1 RCN LNKDGKLDKDEIRHWILPQDyDHAQAEARHLVyESDKNKDE
Q15365 S27 Sugiyama PCBP1 ESGLNVTLTIRLLMHGKEVGsIIGKKGESVKRIREEsGARI
Q15365 S50 Sugiyama PCBP1 GKKGESVKRIREEsGARINIsEGNCPERIItLTGPTNAIFK
Q15365 T127 Sugiyama PCBP1 TQCGsLIGKGGCKIKEIREstGAQVQVAGDMLPNstERAIT
Q15366 S27 Sugiyama PCBP2 EGGLNVTLTIRLLMHGKEVGsIIGKKGESVKKMREESGARI
Q15366 S50 Sugiyama PCBP2 GKKGESVKKMREESGARINIsEGNCPERIITLAGPTNAIFK
Q15366 T127 Sugiyama PCBP2 sQCGsLIGKGGCKIKEIREstGAQVQVAGDMLPNstERAIT
Q15428 S153 Sugiyama SF3A2 SAP62 LFQIDYPEIAEGIMPRHRFMsAyEQRIEPPDRRWQYLLMAA
Q15599 T102 Sugiyama NHERF2 SLC9A3R2 QTRLLVVDQETDEELRRRQLtCTEEMAQRGLPPAHDPWEPK
Q15785 S186 Sugiyama TOMM34 URCC3 HKEMAKSKSKETTATKNRVPsAGDVEKARVLKEEGNELVKK
Q16576 S146 Sugiyama RBBP7 RBAP46 VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC
Q16576 S163 Sugiyama RBBP7 RBAP46 tPssDVLVFDyTKHPAKPDPsGECNPDLRLRGHQKEGYGLS
Q16658 S156 Sugiyama FSCN1 FAN1 HSN SNL IAMHPQVNIYSVTRKRYAHLsARPADEIAVDRDVPWGVDSL
Q16658 S234 Sugiyama FSCN1 FAN1 HSN SNL LEFRsGKVAFRDCEGRyLAPsGPsGtLKAGKATKVGKDELF
Q16695 T59 Sugiyama H3-4 H3FT HIST3H3 PHRyRPGtVALREIRRYQKstELLIRKLPFQRLMREIAQDF
Q16778 S37 Sugiyama H2BC21 H2BFQ HIST2H2BE KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIss
Q2VIR3 S282 Sugiyama EIF2S3B FDVNKPGCEVDDLKGGVAGGsILKGVLKVGQETEVRPGIVS
Q3KQU3 T118 Sugiyama MAP7D1 KIAA1187 PARCC1 RPRC1 PP2464 PPAMGPRDARPPRRssQPsPtAVPAsDsPPtKQEVKKAGER
Q3SY84 S143 Sugiyama KRT71 K6IRS1 KB34 KRT6IRS1 IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q562R1 Y241 Sugiyama ACTBL2 ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q58FF6 S34 Sugiyama HSP90AB4P IFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDIIPN
Q58FF7 S370 Sugiyama HSP90AB3P HSP90BC KETQKSTYYITGESKEQVANsAFVERVRKQGFEVVYMTEPI
Q58FF7 S58 Sugiyama HSP90AB3P HSP90BC IFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FF8 S58 Sugiyama HSP90AB2P HSP90BB IFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FF8 T263 Sugiyama HSP90AB2P HSP90BB FSVEEYVSRMKEIQKsIyyItGEsKEQVANSAFVEQVWKRD
Q58FF8 Y198 Sugiyama HSP90AB2P HSP90BB DEEDDsGKDKKKKTKKIKEKyIDQEELNKTKPIWTRNTEDI
Q5JSH3 T746 Sugiyama WDR44 RPH11 YHTQIHVRSTRGRNKVGRKItGIEPLPGENKILVTSNDSRI
Q5QNW6 S37 Sugiyama H2BC18 HIST2H2BF KAVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q5QNW6 Y38 Sugiyama H2BC18 HIST2H2BF AVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
Q5T5C0 S692 Sugiyama STXBP5 LLGL3 YGSNDPYRREPRSPRKsRQPsGAGLCDIsEGtVVPEDRCKS
Q5VTE0 T432 Sugiyama EEF1A1P5 EEF1AL3 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q5XKE5 S155 Sugiyama KRT79 K6L KB38 KRT6L IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q6DN03 S37 Sugiyama H2BC20P HIST2H2BC KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWC
Q6DRA6 S37 Sugiyama H2BC19P HIST2H2BD KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWC
Q6IBS0 S139 Sugiyama TWF2 PTK9L MSTP011 DELFGTVKDDLSFAGyQKHLssCAAPAPLtsAERELQQIRI
Q6L8Q7 S103 Sugiyama PDE12 LKGHAKAAAAKKSRKsRPNAsGGAACSGPGPEPAVFCEPVV
Q6L8Q7 S98 Sugiyama PDE12 IATNALKGHAKAAAAKKSRKsRPNAsGGAACSGPGPEPAVF
Q6NXT2 T58 Sugiyama H3-5 H3F3C PHRyRPGtVALREIRRYQKstELLIRKLPFQRLVREIAQDF
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6S8J3 Y940 Sugiyama POTEE A26C1A POTE2 ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q6UWE0 S158 Sugiyama LRSAM1 TAL UNQ6496/PRO21356 KLKELPDTVGELRSLRTLNIsGNEIQRLPQMLAHVRTLEML
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q6ZMR3 S167 Sugiyama LDHAL6A LDHL2 AWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIHSESCHG
Q71DI3 T59 Sugiyama H3C15 HIST2H3A; H3C14 H3F2 H3FM HIST2H3C; H3C13 HIST2H3D PHRyRPGtVALREIRRYQKstELLIRKLPFQRLVREIAQDF
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q71UM5 S78 Sugiyama RPS27L GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q7L5Y9 S226 Sugiyama MAEA EMP HLC10 PIG5 IELIRQNKRLDAVRHARKHFsQAEGSQLDEVRQAMGMLAFP
Q7RTS7 S153 Sugiyama KRT74 K6IRS4 KB37 KRT5C KRT6IRS4 IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z4V5 S454 Sugiyama HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 VRPEEKQQAKPVKVERTRKRsEGFsMDRKVEKKKEPSVEEK
Q7Z794 S177 Sugiyama KRT77 KRT1B IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86V86 S182 Sugiyama PIM3 HSCGVVHRDIKDENLLVDLRsGELKLIDFGSGALLKDTVyt
Q86V86 S263 Sugiyama PIM3 IPFEQDEEILRGRLLFRRRVsPECQQLIRWCLSLRPSERPS
Q86V86 T202 Sugiyama PIM3 sGELKLIDFGSGALLKDTVytDFDGtRVySPPEWIRYHRYH
Q86V86 T207 Sugiyama PIM3 LIDFGSGALLKDTVytDFDGtRVySPPEWIRYHRYHGRSAT
Q86V86 Y201 Sugiyama PIM3 RsGELKLIDFGSGALLKDTVytDFDGtRVySPPEWIRYHRY
Q86V86 Y210 Sugiyama PIM3 FGSGALLKDTVytDFDGtRVySPPEWIRYHRYHGRSATVWS
Q86Y46 S145 Sugiyama KRT73 K6IRS3 KB36 KRT6IRS3 IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8IYE1 S680 Sugiyama CCDC13 LTTRLAIQVEENEMLKAALGsALRGKEEDFRMYHEILGQVK
Q8N1G4 T27 Sugiyama LRRC47 KIAA1185 SESWPELELAERERRRELLLtGPGLEERVRAAGGQLPPRLF
Q8N201 S495 Sugiyama INTS1 KIAA1440 UNQ1821/PRO3434 KFLAMVFQDLLTNKDDYLRAsRALLREIIKQTKHEINFQAF
Q8N257 S37 Sugiyama H2BC26 H2BU1 HIST3H2BB KAVTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIss
Q8N684 S166 Sugiyama CPSF7 PGKVLNGEKVDVRPAtRQNLsQFEAQARKRECVRVPRGGIP
Q8N806 S411 Sugiyama UBR7 C14orf130 ADEGTVVKREDIQQFFEEFQsKKRRRVDGMQYYCS______
Q8NBP7 S487 Sugiyama PCSK9 NARC1 PSEC0052 PTRMATAVARCAPDEELLsCssFSRSGKRRGERMEAQGGKL
Q8NFI4 S181 Sugiyama ST13P5 FAM10A5 LQKPNAAIQDCDRAIEINPDsAQPyKWRGKAHRLLGHWEEA
Q8TD16 S658 Sugiyama BICD2 KIAA0699 IKHLQAAVDRTTELSRQRIAsQELGPAVDKDKEALMEEILK
Q8TEW0 S837 Sugiyama PARD3 PAR3 PAR3A AFQREGFGRQsMsEKRtKQFsDAsQLDFVKTRKsKsMDLGI
Q8WUX9 T408 Sugiyama CHMP7 LQDTTKEPLDLPDNPRNRHFtNsVPNPRIsDAELEAELEKL
Q92597 S326 Sugiyama NDRG1 CAP43 DRG1 RTP KYFVQGMGYMPsAsMtRLMRsRtAsGssVtsLDGtRsRsHt
Q92597 S330 Sugiyama NDRG1 CAP43 DRG1 RTP QGMGYMPsAsMtRLMRsRtAsGssVtsLDGtRsRsHtSEGT
Q92734 S50 Sugiyama TFG DITyDELVLMMQRVFRGKLLsNDEVTIKYKDEDGDLITIFD
Q92766 S1167 Sugiyama RREB1 FINB AGTSKKRGRKRGMRSRPRANsGGVDLDssGEFASIEKMLAT
Q92785 S151 Sugiyama DPF2 BAF45D REQ UBID4 RGAPDPRVDDDsLGEFPVTNsRARKRILEPDDFLDDLDDED
Q92934 S118 SIGNOR|iPTMNet|EPSD BAD BBC6 BCL2L8 RsAPPNLWAAQRYGRELRRMsDEFVDsFKKGLPRPKsAGtA
Q92934 S75 SIGNOR|iPTMNet|EPSD|PSP BAD BBC6 BCL2L8 PTSSSHHGGAGAVEIRsRHssyPAGtEDDEGMGEEPsPFRG
Q92934 S99 SIGNOR|iPTMNet|EPSD BAD BBC6 BCL2L8 GtEDDEGMGEEPsPFRGRsRsAPPNLWAAQRYGRELRRMsD
Q93079 S37 Sugiyama H2BC9 H2BFJ HIST1H2BH KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q93079 Y38 Sugiyama H2BC9 H2BFJ HIST1H2BH AVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
Q969S3 S38 Sugiyama ZNF622 ZPR9 MQRAHYKTDWHRYNLRRKVAsMAPVTAEGFQERVRAQRAVA
Q96C19 S74 Sugiyama EFHD2 SWS1 ELSAKLLRRADLNQGIGEPQsPsRRVFNPytEFKEFSRKQI
Q96E14 S78 Sugiyama RMI2 C16orf75 VWMQGRVVMADRGEARLRDPsGDFSVRGLERVPRGRPCLVP
Q96I99 S98 Sugiyama SUCLG2 KEIVLKAQILAGGRGKGVFNsGLKGGVHLTKDPNVVGQLAK
Q96N67 S1432 Sugiyama DOCK7 KIAA1771 RRSRGQLGTYTIAsPPERsPsGsAFGsQENLRWRKDMTHWR
Q96RE7 S330 Sugiyama NACC1 BTBD14B NAC1 MNVGQTAEKVEALPEQVAPEsRNRIRVRQDLASLPAELINQ
Q99613 S638 Sugiyama EIF3C EIF3S8 ICAFRQGLTKDAHNALLDIQssGRAKELLGQGLLLRSLQER
Q99729 S242 Sugiyama HNRNPAB ABBP1 HNRPAB SKCEIKVAQPKEVyQQQQyGsGGRGNRNRGNRGSGGGGGGG
Q99832 S59 Sugiyama CCT7 CCTH NIP7-1 TLGPRGMDKLIVDGRGKAtIsNDGAtILKLLDVVHPAAKTL
Q99877 S37 Sugiyama H2BC15 H2BFD HIST1H2BN KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99877 Y38 Sugiyama H2BC15 H2BFD HIST1H2BN AVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
Q99879 S37 Sugiyama H2BC14 H2BFE HIST1H2BM KAINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99879 Y38 Sugiyama H2BC14 H2BFE HIST1H2BM AINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
Q99880 S37 Sugiyama H2BC13 H2BFC HIST1H2BL KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99880 Y38 Sugiyama H2BC13 H2BFC HIST1H2BL AVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
Q9BQE3 S439 Sugiyama TUBA1C TUBA6 SEAREDMAALEKDyEEVGADsADGEDEGEEy__________
Q9BUJ2 S512 Sugiyama HNRNPUL1 E1BAP5 HNRPUL1 IQIAARKKRNyILDQtNVyGsAQRRKMRPFEGFQRKAIVIC
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9BYX7 Y240 Sugiyama POTEKP ACTBL3 FKSG30 ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9H0A0 S593 Sugiyama NAT10 ALP KIAA1709 VLAVIQVCLEGEISRQSILNsLSRGKKASGDLIPWTVSEQF
Q9H3N1 S226 Sugiyama TMX1 TMX TXNDC TXNDC1 PSEC0085 UNQ235/PRO268 LCPSKRRRPQPYPYPSKKLLsEsAQPLKKVEEEQEADEEDV
Q9H6H4 S152 Sugiyama REEP4 C8orf20 PP432 AAVQAATKSQGALAGRLRsFsMQDLRSISDAPAPAyHDPLy
Q9H7D7 S121 Sugiyama WDR26 CDW2 MIP2 PRO0852 ASSSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLN
Q9NSB2 S178 Sugiyama KRT84 KRTHB4 AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9NSE4 S98 Sugiyama IARS2 RQQPDtELEIQQKCGFSELysWQRERKVKTEFCLHDGPPYA
Q9NYV4 S1053 Sugiyama CDK12 CRK7 CRKRS KIAA0904 LPHWQDCHELWSKKRRRQRQsGVVVEEPPPSKTSRKETtsG
Q9NZN8 S242 Sugiyama CNOT2 CDC36 NOT2 HSPC131 MSTP046 VTGLDLSDFPALADRNRREGsGNPtPLINPLAGRAPYVGMV
Q9UBP6 S27 Sugiyama METTL1 C12orf1 NVAGAEAPPPQKRYYRQRAHsNPMADHTLRYPVKPEEMDWS
Q9UBR2 S78 Sugiyama CTSZ SPADLPKSWDWRNVDGVNyAsItRNQHIPQYCGSCWAHAST
Q9UGV2 S331 Sugiyama NDRG3 QGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQ
Q9UGV2 S333 Sugiyama NDRG3 MGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsD
Q9UGV2 S334 Sugiyama NDRG3 GYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsDG
Q9UGV2 T332 Sugiyama NDRG3 GMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQs
Q9UJ70 S76 Sugiyama NAGK AKRKAGVDPLVPLRsLGLsLsGGDQEDAGRILIEELRDRFP
Q9UNN5 S582 Sugiyama FAF1 UBXD12 UBXN3A CGI-03 PPEPKEENAEPVSKLRIRtPsGEFLERRFLASNKLQIVFDF
Q9UQ35 S2453 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 QAPsQsLLPPAQDQPRsPVPsAFsDQsRCLIAQTTPVAGSQ
Q9UQ80 S267 Sugiyama PA2G4 EBP1 YKRDPSKQYGLKMKtSRAFFsEVERRFDAMPFtLRAFEDEK
Q9UQ80 S335 Sugiyama PA2G4 EBP1 FVAQFKFTVLLMPNGPMRITsGPFEPDLyKsEMEVQDAELK
Q9UQ80 T377 Sugiyama PA2G4 EBP1 LLQssAsRKtQKKKKKKAsKtAENAtsGEtLEENEAGD___
Q9Y262 S249 Sugiyama EIF3L EIF3EIP EIF3S6IP HSPC021 HSPC025 MSTP005 NVLHSLVDKSNINRQLEVytsGGDPEsVAGEyGRHSLYKML
Q9Y2B0 S116 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 IDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKFA
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2I7 S307 Sugiyama PIKFYVE KIAA0981 PIP5K3 TRLVSVQEDAGKsPARNRsAsItNLsLDRsGsPMVPSYEts
Q9Y2V2 S52 Sugiyama CARHSP1 sPLRGNVVPsPLPtRRtRtFsAtVRASQGPVYKGVCKCFCR
Q9Y2X7 S592 Sugiyama GIT1 PLLsCsQEGsRHtsKLsRHGsGADsDyENtQSGDPLLGLEG
Q9Y3F4 S153 Sugiyama STRAP MAWD UNRIP EAEPKEISGHTSGIKKALWCsEDKQILsADDKtVRLWDHAT
Q9Y3F4 S254 Sugiyama STRAP MAWD UNRIP EKEFLVAGGEDFKLyKyDyNsGEELEsyKGHFGPIHCVRFS
Q9Y3U8 S91 Sugiyama RPL36 KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Q9Y5S9 S56 Sugiyama RBM8A RBM8 HSPC114 MDS014 KGRGFGsEEGsRARMREDyDsVEQDGDEPGPQRSVEGWILF
Q9Y697 S283 Sugiyama NFS1 NIFS HUSSY-08 KGVGAIYIRRRPRVRVEALQsGGGQERGMRsGTVPTPLVVG
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 7.268144e-07 6.139 0 0
mRNA Splicing - Major Pathway R-HSA-72163 8.633971e-07 6.064 0 0
mRNA Splicing R-HSA-72172 1.714405e-06 5.766 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 4.699016e-06 5.328 0 0
Gene expression (Transcription) R-HSA-74160 8.656503e-06 5.063 0 0
RNA Polymerase II Transcription R-HSA-73857 1.020112e-05 4.991 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 3.131791e-05 4.504 0 0
Chromatin organization R-HSA-4839726 3.505132e-05 4.455 0 0
Apoptotic execution phase R-HSA-75153 4.123383e-05 4.385 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.628088e-05 4.335 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 7.463736e-05 4.127 0 0
Generic Transcription Pathway R-HSA-212436 8.493880e-05 4.071 0 0
Activation of RAC1 R-HSA-428540 1.010141e-04 3.996 0 0
Signal Transduction R-HSA-162582 1.523628e-04 3.817 0 0
Chromatin modifying enzymes R-HSA-3247509 1.712452e-04 3.766 0 0
Regulation of TP53 Activity R-HSA-5633007 2.976223e-04 3.526 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 3.491815e-04 3.457 0 0
Signaling by NTRKs R-HSA-166520 5.937420e-04 3.226 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 7.031255e-04 3.153 0 0
Signaling by ALK in cancer R-HSA-9700206 7.031255e-04 3.153 0 0
Germ layer formation at gastrulation R-HSA-9754189 7.499176e-04 3.125 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 7.913956e-04 3.102 0 0
mRNA 3'-end processing R-HSA-72187 1.137582e-03 2.944 0 0
Specification of primordial germ cells R-HSA-9827857 1.530670e-03 2.815 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.023604e-03 2.694 0 0
G alpha (12/13) signalling events R-HSA-416482 1.991136e-03 2.701 0 0
Death Receptor Signaling R-HSA-73887 1.995861e-03 2.700 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.068732e-03 2.684 0 0
NRAGE signals death through JNK R-HSA-193648 2.210681e-03 2.655 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.283315e-03 2.641 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.283315e-03 2.641 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.950899e-03 2.530 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.001954e-03 2.523 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 3.343632e-03 2.476 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 3.496060e-03 2.456 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 4.184283e-03 2.378 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 4.227135e-03 2.374 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 4.263976e-03 2.370 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 4.602219e-03 2.337 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 4.803086e-03 2.318 0 0
Signaling by ROBO receptors R-HSA-376176 4.727392e-03 2.325 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.803086e-03 2.318 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 5.106396e-03 2.292 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 5.106396e-03 2.292 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 5.324577e-03 2.274 0 0
Cell Cycle R-HSA-1640170 5.618540e-03 2.250 0 0
Axon guidance R-HSA-422475 5.631479e-03 2.249 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 5.669487e-03 2.246 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 6.039962e-03 2.219 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 6.122524e-03 2.213 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 7.541118e-03 2.123 0 0
HATs acetylate histones R-HSA-3214847 7.910483e-03 2.102 0 0
NGF-stimulated transcription R-HSA-9031628 8.492415e-03 2.071 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 9.901807e-03 2.004 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.034251e-02 1.985 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.030995e-02 1.987 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.123534e-02 1.949 0 0
Signaling by LTK R-HSA-9842663 1.322587e-02 1.879 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.409254e-02 1.851 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.527796e-02 1.816 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.530358e-02 1.815 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 1.609486e-02 1.793 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 1.609486e-02 1.793 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.609486e-02 1.793 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.699808e-02 1.770 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.726071e-02 1.763 0 0
Nervous system development R-HSA-9675108 1.846418e-02 1.734 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.031077e-02 1.692 0 0
Nuclear RNA decay R-HSA-9930044 2.031077e-02 1.692 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.073287e-02 1.683 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.084618e-02 1.681 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 2.253460e-02 1.647 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 2.253460e-02 1.647 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.172838e-02 1.663 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.172838e-02 1.663 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.241133e-02 1.650 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.414363e-02 1.617 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.414363e-02 1.617 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.414363e-02 1.617 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.414363e-02 1.617 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.414363e-02 1.617 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.414363e-02 1.617 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.352771e-02 1.628 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.415811e-02 1.617 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.770699e-02 1.557 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.651657e-02 1.576 0 0
Cell Cycle Checkpoints R-HSA-69620 2.636266e-02 1.579 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.747435e-02 1.561 0 0
Formation of the anterior neural plate R-HSA-9823739 2.770699e-02 1.557 0 0
MTF1 activates gene expression R-HSA-5660489 3.573220e-02 1.447 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.274043e-02 1.485 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 3.274043e-02 1.485 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.274043e-02 1.485 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 3.510991e-02 1.455 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 3.197690e-02 1.495 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.197690e-02 1.495 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.197690e-02 1.495 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.197690e-02 1.495 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.197690e-02 1.495 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.037071e-02 1.518 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 3.392582e-02 1.469 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.438439e-02 1.464 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 3.438439e-02 1.464 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 3.438439e-02 1.464 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 3.573220e-02 1.447 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 3.573220e-02 1.447 0 0
Dopamine receptors R-HSA-390651 3.573220e-02 1.447 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.307058e-02 1.481 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 3.179608e-02 1.498 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.257281e-02 1.487 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 3.422110e-02 1.466 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.508760e-02 1.455 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.604598e-02 1.443 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.604598e-02 1.443 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.636291e-02 1.439 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.820347e-02 1.418 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 4.008013e-02 1.397 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 4.413941e-02 1.355 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 4.164945e-02 1.380 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 4.164945e-02 1.380 0 0
Adrenoceptors R-HSA-390696 4.378508e-02 1.359 0 0
Interleukin-15 signaling R-HSA-8983432 4.413941e-02 1.355 0 0
Signaling by PDGFR in disease R-HSA-9671555 4.503812e-02 1.346 0 0
Metabolism of RNA R-HSA-8953854 4.642799e-02 1.333 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 4.666215e-02 1.331 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 4.666215e-02 1.331 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 4.666215e-02 1.331 0 0
Signaling by Hippo R-HSA-2028269 5.002012e-02 1.301 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 5.049067e-02 1.297 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 5.209804e-02 1.283 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 5.666974e-02 1.247 0 0
ALK mutants bind TKIs R-HSA-9700645 5.666974e-02 1.247 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.623466e-02 1.250 0 0
Resolution of D-Loop Structures R-HSA-5693537 5.300850e-02 1.276 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 5.666974e-02 1.247 0 0
Intracellular signaling by second messengers R-HSA-9006925 5.702639e-02 1.244 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.120710e-01 0.951 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.120710e-01 0.951 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.120710e-01 0.951 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.120710e-01 0.951 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.120710e-01 0.951 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.120710e-01 0.951 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.120710e-01 0.951 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 8.283010e-02 1.082 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 8.283010e-02 1.082 0 0
Regulation of cortical dendrite branching R-HSA-8985801 8.283010e-02 1.082 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 8.283010e-02 1.082 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 8.283010e-02 1.082 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 8.283010e-02 1.082 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 8.283010e-02 1.082 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 8.283010e-02 1.082 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 8.283010e-02 1.082 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 8.283010e-02 1.082 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 8.283010e-02 1.082 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 8.283010e-02 1.082 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.115880e-01 0.675 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.115880e-01 0.675 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.115880e-01 0.675 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.115880e-01 0.675 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.115880e-01 0.675 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.115880e-01 0.675 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.115880e-01 0.675 0 0
Tandem pore domain halothane-inhibited K+ channel (THIK) R-HSA-1299287 2.115880e-01 0.675 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 7.144600e-02 1.146 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 7.144600e-02 1.146 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 7.144600e-02 1.146 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 7.144600e-02 1.146 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 9.351475e-02 1.029 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.603732e-01 0.795 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.603732e-01 0.795 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.603732e-01 0.795 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.603732e-01 0.795 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.999565e-01 0.523 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 2.999565e-01 0.523 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.999565e-01 0.523 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.999565e-01 0.523 0 0
IKBKB deficiency causes SCID R-HSA-5602636 2.999565e-01 0.523 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.999565e-01 0.523 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 7.136313e-02 1.147 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.179955e-01 0.928 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.179955e-01 0.928 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.179955e-01 0.928 0 0
SOS-mediated signalling R-HSA-112412 1.179955e-01 0.928 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 8.779991e-02 1.057 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 2.027474e-01 0.693 0 0
IRS activation R-HSA-74713 2.027474e-01 0.693 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.027474e-01 0.693 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.027474e-01 0.693 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 6.600640e-02 1.180 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.058862e-01 0.975 0 0
DCC mediated attractive signaling R-HSA-418885 7.883901e-02 1.103 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 7.883901e-02 1.103 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.255050e-01 0.901 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.255050e-01 0.901 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 1.255050e-01 0.901 0 0
Pervasive developmental disorders R-HSA-9005895 1.255050e-01 0.901 0 0
Disorders of Nervous System Development R-HSA-9697154 1.255050e-01 0.901 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.255050e-01 0.901 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.255050e-01 0.901 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.255050e-01 0.901 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.255050e-01 0.901 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.255050e-01 0.901 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 2.461734e-01 0.609 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.784248e-01 0.422 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.784248e-01 0.422 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 3.784248e-01 0.422 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 3.784248e-01 0.422 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.784248e-01 0.422 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) R-HSA-5619049 3.784248e-01 0.422 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.784248e-01 0.422 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.784248e-01 0.422 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 8.091567e-02 1.092 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 8.091567e-02 1.092 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 1.081649e-01 0.966 0 0
Disorders of Developmental Biology R-HSA-9675151 1.081649e-01 0.966 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.465216e-01 0.834 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 2.025294e-01 0.694 0 0
PI3K/AKT activation R-HSA-198203 2.025294e-01 0.694 0 0
Folding of actin by CCT/TriC R-HSA-390450 2.025294e-01 0.694 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 6.103622e-02 1.214 0 0
TGFBR3 expression R-HSA-9839394 8.026904e-02 1.095 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 8.026904e-02 1.095 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 2.898836e-01 0.538 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 9.101672e-02 1.041 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 9.101672e-02 1.041 0 0
Ephrin signaling R-HSA-3928664 1.420223e-01 0.848 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 1.420223e-01 0.848 0 0
Downstream signal transduction R-HSA-186763 7.817700e-02 1.107 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.203470e-01 0.920 0 0
ChREBP activates metabolic gene expression R-HSA-163765 2.332767e-01 0.632 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.332767e-01 0.632 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 2.332767e-01 0.632 0 0
Signaling by APC mutants R-HSA-4839744 2.332767e-01 0.632 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.332767e-01 0.632 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.332767e-01 0.632 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.332767e-01 0.632 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.025303e-01 0.989 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.025303e-01 0.989 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.025303e-01 0.989 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.025303e-01 0.989 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.921495e-01 0.716 0 0
Erythropoietin activates RAS R-HSA-9027284 1.921495e-01 0.716 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.921495e-01 0.716 0 0
HIV elongation arrest and recovery R-HSA-167287 1.147944e-01 0.940 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.147944e-01 0.940 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 8.385299e-02 1.076 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 6.206805e-02 1.207 0 0
Signaling downstream of RAS mutants R-HSA-9649948 6.206805e-02 1.207 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 6.206805e-02 1.207 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 2.647766e-01 0.577 0 0
NF-kB is activated and signals survival R-HSA-209560 2.647766e-01 0.577 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.332692e-01 0.477 0 0
TRIF-mediated programmed cell death R-HSA-2562578 3.332692e-01 0.477 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 3.332692e-01 0.477 0 0
MET activates STAT3 R-HSA-8875791 4.481017e-01 0.349 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 4.481017e-01 0.349 0 0
Axonal growth stimulation R-HSA-209563 4.481017e-01 0.349 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.481017e-01 0.349 0 0
Invadopodia formation R-HSA-8941237 4.481017e-01 0.349 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.481017e-01 0.349 0 0
Signalling to STAT3 R-HSA-198745 4.481017e-01 0.349 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.481017e-01 0.349 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 7.556398e-02 1.122 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.202046e-01 0.920 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.202046e-01 0.920 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 2.000139e-01 0.699 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.235522e-01 0.908 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.967409e-01 0.528 0 0
IRAK1 recruits IKK complex R-HSA-937039 2.967409e-01 0.528 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 2.967409e-01 0.528 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 2.967409e-01 0.528 0 0
RET signaling R-HSA-8853659 1.449411e-01 0.839 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.209121e-01 0.656 0 0
MAP2K and MAPK activation R-HSA-5674135 1.348231e-01 0.870 0 0
Type I hemidesmosome assembly R-HSA-446107 3.758541e-01 0.425 0 0
Regulation by c-FLIP R-HSA-3371378 3.758541e-01 0.425 0 0
RSK activation R-HSA-444257 3.758541e-01 0.425 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 3.758541e-01 0.425 0 0
Dimerization of procaspase-8 R-HSA-69416 3.758541e-01 0.425 0 0
Formation of annular gap junctions R-HSA-196025 3.758541e-01 0.425 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.864749e-01 0.729 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.014968e-01 0.994 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.289068e-01 0.483 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.289068e-01 0.483 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 3.289068e-01 0.483 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.026423e-01 0.693 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.862585e-01 0.730 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.933257e-01 0.533 0 0
RAF activation R-HSA-5673000 2.193235e-01 0.659 0 0
HIV Transcription Elongation R-HSA-167169 2.010447e-01 0.697 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.010447e-01 0.697 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 2.010447e-01 0.697 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.010447e-01 0.697 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 2.597114e-01 0.586 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.869564e-01 0.542 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 3.197687e-01 0.495 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 4.172731e-01 0.380 0 0
ARMS-mediated activation R-HSA-170984 4.172731e-01 0.380 0 0
Interleukin-21 signaling R-HSA-9020958 4.172731e-01 0.380 0 0
WNT mediated activation of DVL R-HSA-201688 4.172731e-01 0.380 0 0
Gap junction degradation R-HSA-190873 4.172731e-01 0.380 0 0
CASP8 activity is inhibited R-HSA-5218900 4.172731e-01 0.380 0 0
Regulation of gap junction activity R-HSA-191650 5.099716e-01 0.292 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.099716e-01 0.292 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 5.099716e-01 0.292 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.099716e-01 0.292 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 5.099716e-01 0.292 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 5.099716e-01 0.292 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.099716e-01 0.292 0 0
Signaling by MAP2K mutants R-HSA-9652169 5.099716e-01 0.292 0 0
Defective CP causes aceruloplasminemia (ACERULOP) R-HSA-5619060 5.099716e-01 0.292 0 0
Meiotic synapsis R-HSA-1221632 1.954211e-01 0.709 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 2.540391e-01 0.595 0 0
Trafficking of AMPA receptors R-HSA-399719 2.796027e-01 0.553 0 0
Spry regulation of FGF signaling R-HSA-1295596 3.929246e-01 0.406 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 3.929246e-01 0.406 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 3.929246e-01 0.406 0 0
Integrin signaling R-HSA-354192 3.203036e-01 0.494 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.203036e-01 0.494 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 4.572525e-01 0.340 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 3.087542e-01 0.510 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.359589e-01 0.627 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.067260e-01 0.685 0 0
Nuclear Receptor transcription pathway R-HSA-383280 2.294613e-01 0.639 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.014244e-01 0.696 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.913085e-01 0.718 0 0
Striated Muscle Contraction R-HSA-390522 3.409787e-01 0.467 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 4.243838e-01 0.372 0 0
AURKA Activation by TPX2 R-HSA-8854518 2.697498e-01 0.569 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 2.278445e-01 0.642 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.613821e-01 0.583 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.995703e-01 0.398 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.039052e-01 0.517 0 0
Telomere Extension By Telomerase R-HSA-171319 3.792268e-01 0.421 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 3.617831e-01 0.442 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.286784e-01 0.641 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.286784e-01 0.641 0 0
Transcription of the HIV genome R-HSA-167172 2.977006e-01 0.526 0 0
Centrosome maturation R-HSA-380287 2.876895e-01 0.541 0 0
HDACs deacetylate histones R-HSA-3214815 3.362709e-01 0.473 0 0
Late endosomal microautophagy R-HSA-9615710 4.024413e-01 0.395 0 0
FGFR2 alternative splicing R-HSA-6803529 4.259188e-01 0.371 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 4.552580e-01 0.342 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 4.955947e-01 0.305 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.649089e-01 0.248 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 5.649089e-01 0.248 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.649089e-01 0.248 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.649089e-01 0.248 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.649089e-01 0.248 0 0
Defective F9 activation R-HSA-9673221 5.649089e-01 0.248 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.649089e-01 0.248 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.666909e-01 0.574 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 3.389647e-01 0.470 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 3.389647e-01 0.470 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 3.061235e-01 0.514 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.255515e-01 0.371 0 0
Regulation of RAS by GAPs R-HSA-5658442 3.854482e-01 0.414 0 0
Interleukin receptor SHC signaling R-HSA-912526 4.519621e-01 0.345 0 0
Metabolism of non-coding RNA R-HSA-194441 4.023623e-01 0.395 0 0
snRNP Assembly R-HSA-191859 4.023623e-01 0.395 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 3.698335e-01 0.432 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.776087e-01 0.321 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 4.776087e-01 0.321 0 0
Deadenylation of mRNA R-HSA-429947 4.776087e-01 0.321 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 5.321646e-01 0.274 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.321646e-01 0.274 0 0
ERKs are inactivated R-HSA-202670 5.321646e-01 0.274 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 5.147403e-01 0.288 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.607036e-01 0.337 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 4.935577e-01 0.307 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 4.449123e-01 0.352 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 5.155805e-01 0.288 0 0
Regulation of signaling by CBL R-HSA-912631 5.431474e-01 0.265 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 5.431474e-01 0.265 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 6.136900e-01 0.212 0 0
PDE3B signalling R-HSA-165160 6.136900e-01 0.212 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.136900e-01 0.212 0 0
PKB-mediated events R-HSA-109703 6.136900e-01 0.212 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 6.136900e-01 0.212 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 6.136900e-01 0.212 0 0
Regulation of endogenous retroelements R-HSA-9842860 4.744120e-01 0.324 0 0
Viral mRNA Translation R-HSA-192823 4.874081e-01 0.312 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 5.258821e-01 0.279 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 5.514077e-01 0.259 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 5.514077e-01 0.259 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 5.453584e-01 0.263 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 5.747567e-01 0.241 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 5.747567e-01 0.241 0 0
Formation of the Early Elongation Complex R-HSA-113418 5.747567e-01 0.241 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 5.645830e-01 0.248 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 5.679600e-01 0.246 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 5.969370e-01 0.224 0 0
Signaling by Erythropoietin R-HSA-9006335 5.974019e-01 0.224 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 5.974019e-01 0.224 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.974019e-01 0.224 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 5.974019e-01 0.224 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 6.021049e-01 0.220 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 6.014886e-01 0.221 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 6.014886e-01 0.221 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 6.014886e-01 0.221 0 0
Nucleosome assembly R-HSA-774815 6.014886e-01 0.221 0 0
Translation initiation complex formation R-HSA-72649 6.041180e-01 0.219 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 6.193439e-01 0.208 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 6.193090e-01 0.208 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 6.193090e-01 0.208 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 6.222273e-01 0.206 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 6.222273e-01 0.206 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 6.305926e-01 0.200 0 0
Retrograde neurotrophin signalling R-HSA-177504 6.305926e-01 0.200 0 0
FOXO-mediated transcription R-HSA-9614085 1.129253e-01 0.947 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.128137e-01 0.672 0 0
Hedgehog 'off' state R-HSA-5610787 1.779900e-01 0.750 0 0
Circadian clock R-HSA-9909396 3.993806e-01 0.399 0 0
RNA Polymerase III Transcription R-HSA-74158 2.540391e-01 0.595 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.801006e-01 0.744 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.164786e-01 0.934 0 0
IGF1R signaling cascade R-HSA-2428924 2.427019e-01 0.615 0 0
DNA Double Strand Break Response R-HSA-5693606 2.836232e-01 0.547 0 0
Specification of the neural plate border R-HSA-9834899 1.604764e-01 0.795 0 0
Recycling pathway of L1 R-HSA-437239 4.794848e-01 0.319 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.417772e-01 0.355 0 0
p75NTR signals via NF-kB R-HSA-193639 1.921495e-01 0.716 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 9.030318e-02 1.044 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 6.193090e-01 0.208 0 0
Chromosome Maintenance R-HSA-73886 5.382561e-01 0.269 0 0
Insulin receptor signalling cascade R-HSA-74751 6.223061e-01 0.206 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.751217e-01 0.240 0 0
DNA Double-Strand Break Repair R-HSA-5693532 3.040634e-01 0.517 0 0
Oncogenic MAPK signaling R-HSA-6802957 9.488971e-02 1.023 0 0
EPH-Ephrin signaling R-HSA-2682334 2.387314e-01 0.622 0 0
ESR-mediated signaling R-HSA-8939211 2.879229e-01 0.541 0 0
Ribosome-associated quality control R-HSA-9948299 5.710744e-01 0.243 0 0
Prolonged ERK activation events R-HSA-169893 9.290611e-02 1.032 0 0
Extension of Telomeres R-HSA-180786 5.422298e-01 0.266 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 2.415110e-01 0.617 0 0
G0 and Early G1 R-HSA-1538133 1.708657e-01 0.767 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 5.321646e-01 0.274 0 0
p75NTR recruits signalling complexes R-HSA-209543 5.668775e-01 0.247 0 0
EPHB-mediated forward signaling R-HSA-3928662 5.831900e-01 0.234 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.152115e-01 0.501 0 0
Synaptic adhesion-like molecules R-HSA-8849932 1.420223e-01 0.848 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.790128e-01 0.237 0 0
Homology Directed Repair R-HSA-5693538 2.316416e-01 0.635 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 3.263791e-01 0.486 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.804872e-01 0.318 0 0
Polo-like kinase mediated events R-HSA-156711 5.935112e-02 1.227 0 0
G-protein beta:gamma signalling R-HSA-397795 4.935577e-01 0.307 0 0
TNF signaling R-HSA-75893 2.356448e-01 0.628 0 0
Signal attenuation R-HSA-74749 7.136313e-02 1.147 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 6.732488e-02 1.172 0 0
Signaling by RAF1 mutants R-HSA-9656223 7.204553e-02 1.142 0 0
Myogenesis R-HSA-525793 1.847871e-01 0.733 0 0
Repression of WNT target genes R-HSA-4641265 2.967409e-01 0.528 0 0
Epigenetic regulation of gene expression R-HSA-212165 6.548972e-02 1.184 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 3.409351e-01 0.467 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.255515e-01 0.371 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.780257e-01 0.750 0 0
Adipogenesis R-HSA-9843745 5.776588e-01 0.238 0 0
Signaling by ERBB2 R-HSA-1227986 5.588066e-01 0.253 0 0
Frs2-mediated activation R-HSA-170968 1.465216e-01 0.834 0 0
MHC class II antigen presentation R-HSA-2132295 2.809774e-01 0.551 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 3.828321e-01 0.417 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 2.561023e-01 0.592 0 0
Mitotic Prometaphase R-HSA-68877 3.130988e-01 0.504 0 0
Formation of the posterior neural plate R-HSA-9832991 8.779991e-02 1.057 0 0
Regulation of TP53 Degradation R-HSA-6804757 7.531046e-02 1.123 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.359394e-01 0.867 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 4.172731e-01 0.380 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.883112e-01 0.725 0 0
DARPP-32 events R-HSA-180024 5.974019e-01 0.224 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 3.325868e-01 0.478 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 5.273974e-01 0.278 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 4.552580e-01 0.342 0 0
Meiosis R-HSA-1500620 1.492806e-01 0.826 0 0
Signaling by PDGF R-HSA-186797 3.236230e-01 0.490 0 0
Regulation of CDH11 function R-HSA-9762292 2.025294e-01 0.694 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 2.025294e-01 0.694 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 9.295272e-02 1.032 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.708657e-01 0.767 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.758541e-01 0.425 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.172731e-01 0.380 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 4.243838e-01 0.372 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 3.617831e-01 0.442 0 0
Peptide chain elongation R-HSA-156902 2.694611e-01 0.570 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 4.854138e-01 0.314 0 0
MET activates RAS signaling R-HSA-8851805 5.668775e-01 0.247 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 6.136900e-01 0.212 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 4.952055e-01 0.305 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 5.705643e-01 0.244 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 5.712723e-01 0.243 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.485510e-01 0.605 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.845269e-01 0.415 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 3.958810e-01 0.402 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 5.839526e-01 0.234 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.457113e-01 0.837 0 0
Signaling by RAS mutants R-HSA-6802949 6.206805e-02 1.207 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 5.158008e-01 0.288 0 0
Clathrin-mediated endocytosis R-HSA-8856828 4.518847e-01 0.345 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.995703e-01 0.398 0 0
Netrin-1 signaling R-HSA-373752 9.658321e-02 1.015 0 0
Signaling by FGFR2 R-HSA-5654738 4.744276e-01 0.324 0 0
Signaling by FGFR4 R-HSA-5654743 4.036466e-01 0.394 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 2.967409e-01 0.528 0 0
G2/M DNA damage checkpoint R-HSA-69473 7.041481e-02 1.152 0 0
Sodium/Proton exchangers R-HSA-425986 3.758541e-01 0.425 0 0
Pyroptosis R-HSA-5620971 2.211870e-01 0.655 0 0
p75NTR regulates axonogenesis R-HSA-193697 4.172731e-01 0.380 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 4.172731e-01 0.380 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.649089e-01 0.248 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 3.263791e-01 0.486 0 0
Separation of Sister Chromatids R-HSA-2467813 2.604909e-01 0.584 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 4.744276e-01 0.324 0 0
Signaling by MST1 R-HSA-8852405 6.136900e-01 0.212 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 5.996903e-01 0.222 0 0
Activation of HOX genes during differentiation R-HSA-5619507 5.132014e-01 0.290 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 5.132014e-01 0.290 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 5.974019e-01 0.224 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 6.193090e-01 0.208 0 0
Regulated Necrosis R-HSA-5218859 4.169956e-01 0.380 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.798813e-01 0.237 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 6.242317e-01 0.205 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.766140e-01 0.753 0 0
Signaling by Hedgehog R-HSA-5358351 3.031658e-01 0.518 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.847871e-01 0.733 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 5.164672e-01 0.287 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 5.173777e-01 0.286 0 0
Signaling by FGFR3 R-HSA-5654741 4.417772e-01 0.355 0 0
Signalling to ERKs R-HSA-187687 2.364719e-01 0.626 0 0
ERK/MAPK targets R-HSA-198753 9.313549e-02 1.031 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.026068e-01 0.989 0 0
Mitotic Spindle Checkpoint R-HSA-69618 7.709172e-02 1.113 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.617831e-01 0.442 0 0
Long-term potentiation R-HSA-9620244 5.027774e-01 0.299 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.668775e-01 0.247 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 5.668775e-01 0.247 0 0
Generation of second messenger molecules R-HSA-202433 4.859771e-01 0.313 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 4.572525e-01 0.340 0 0
Meiotic recombination R-HSA-912446 5.524606e-01 0.258 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 4.209219e-01 0.376 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.539209e-01 0.451 0 0
TCR signaling R-HSA-202403 5.881428e-01 0.231 0 0
Signaling by FGFR1 R-HSA-5654736 4.911558e-01 0.309 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.348231e-01 0.870 0 0
Neurexins and neuroligins R-HSA-6794361 1.077227e-01 0.968 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.418082e-01 0.617 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.418082e-01 0.617 0 0
M Phase R-HSA-68886 2.934257e-01 0.533 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.461734e-01 0.609 0 0
Synthesis of PI R-HSA-1483226 2.332767e-01 0.632 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 3.332692e-01 0.477 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 3.758541e-01 0.425 0 0
TGFBR3 PTM regulation R-HSA-9839383 3.758541e-01 0.425 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.864749e-01 0.729 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 3.610379e-01 0.442 0 0
GP1b-IX-V activation signalling R-HSA-430116 4.172731e-01 0.380 0 0
Calcineurin activates NFAT R-HSA-2025928 4.172731e-01 0.380 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 3.929246e-01 0.406 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 3.730188e-01 0.428 0 0
Eukaryotic Translation Elongation R-HSA-156842 2.387314e-01 0.622 0 0
PTK6 Activates STAT3 R-HSA-8849474 5.649089e-01 0.248 0 0
Activation of AKT2 R-HSA-165158 5.649089e-01 0.248 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.649089e-01 0.248 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.255515e-01 0.371 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.899363e-01 0.538 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 4.854138e-01 0.314 0 0
Post NMDA receptor activation events R-HSA-438064 3.567528e-01 0.448 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.129642e-01 0.384 0 0
Aggrephagy R-HSA-9646399 4.859771e-01 0.313 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 5.371925e-01 0.270 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 5.453584e-01 0.263 0 0
Negative regulation of MET activity R-HSA-6807004 5.705643e-01 0.244 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.784303e-01 0.555 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.784303e-01 0.555 0 0
Signaling by Nuclear Receptors R-HSA-9006931 6.109051e-01 0.214 0 0
Hedgehog 'on' state R-HSA-5632684 2.359589e-01 0.627 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.391770e-01 0.470 0 0
DAP12 signaling R-HSA-2424491 6.193090e-01 0.208 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.719755e-01 0.565 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.934158e-01 0.533 0 0
Signaling by EGFR R-HSA-177929 3.526713e-01 0.453 0 0
Cilium Assembly R-HSA-5617833 5.948963e-01 0.226 0 0
Signaling by WNT R-HSA-195721 4.437882e-01 0.353 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 7.556398e-02 1.122 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 4.172731e-01 0.380 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 4.686330e-01 0.329 0 0
PTEN Regulation R-HSA-6807070 5.818902e-01 0.235 0 0
MTOR signalling R-HSA-165159 2.479852e-01 0.606 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 3.224178e-01 0.492 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.899363e-01 0.538 0 0
Signaling by TGFBR3 R-HSA-9839373 6.206805e-02 1.207 0 0
Membrane Trafficking R-HSA-199991 4.483447e-01 0.348 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 4.259188e-01 0.371 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 6.153499e-02 1.211 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 3.224178e-01 0.492 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 3.557984e-01 0.449 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 3.758541e-01 0.425 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 3.610379e-01 0.442 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 5.099716e-01 0.292 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 4.854138e-01 0.314 0 0
Eukaryotic Translation Termination R-HSA-72764 3.828321e-01 0.417 0 0
S Phase R-HSA-69242 4.168767e-01 0.380 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 6.305926e-01 0.200 0 0
Cell junction organization R-HSA-446728 4.170693e-01 0.380 0 0
Adherens junctions interactions R-HSA-418990 4.718134e-01 0.326 0 0
Mitotic Anaphase R-HSA-68882 5.871239e-02 1.231 0 0
Cardiogenesis R-HSA-9733709 9.791430e-02 1.009 0 0
Cell Cycle, Mitotic R-HSA-69278 1.722818e-01 0.764 0 0
Cell-cell junction organization R-HSA-421270 6.093975e-01 0.215 0 0
Ion homeostasis R-HSA-5578775 3.526713e-01 0.453 0 0
Mismatch Repair R-HSA-5358508 5.147403e-01 0.288 0 0
Negative regulation of MAPK pathway R-HSA-5675221 5.258821e-01 0.279 0 0
Mitotic Prophase R-HSA-68875 5.264041e-01 0.279 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 3.557984e-01 0.449 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.519621e-01 0.345 0 0
G2/M Checkpoints R-HSA-69481 3.335477e-01 0.477 0 0
Ub-specific processing proteases R-HSA-5689880 2.150635e-01 0.667 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 4.089655e-01 0.388 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 2.027474e-01 0.693 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.058862e-01 0.975 0 0
Rap1 signalling R-HSA-392517 3.197687e-01 0.495 0 0
Gastrulation R-HSA-9758941 4.274779e-01 0.369 0 0
Programmed Cell Death R-HSA-5357801 9.738171e-02 1.012 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.864749e-01 0.729 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.103192e-01 0.677 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 4.854138e-01 0.314 0 0
Cell-Cell communication R-HSA-1500931 3.921054e-01 0.407 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.531289e-01 0.597 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 2.295693e-01 0.639 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 6.182188e-01 0.209 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.793536e-01 0.554 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 3.563457e-01 0.448 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 4.776087e-01 0.321 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 3.423615e-01 0.466 0 0
Semaphorin interactions R-HSA-373755 1.457113e-01 0.837 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.277881e-01 0.894 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.566199e-01 0.448 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 3.686459e-01 0.433 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 6.182188e-01 0.209 0 0
Deubiquitination R-HSA-5688426 2.455758e-01 0.610 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.318779e-01 0.635 0 0
Interleukin-2 family signaling R-HSA-451927 2.010447e-01 0.697 0 0
Signaling by ALK R-HSA-201556 1.026068e-01 0.989 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.060149e-01 0.296 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.057345e-01 0.976 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.318779e-01 0.635 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.318779e-01 0.635 0 0
Signaling by NOTCH1 R-HSA-1980143 5.404179e-01 0.267 0 0
Organelle biogenesis and maintenance R-HSA-1852241 4.217128e-01 0.375 0 0
Cellular Senescence R-HSA-2559583 5.735693e-02 1.241 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.215163e-01 0.655 0 0
Apoptosis R-HSA-109581 9.587530e-02 1.018 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.603732e-01 0.795 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 2.999565e-01 0.523 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.999565e-01 0.523 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 2.027474e-01 0.693 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 1.728454e-01 0.762 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 2.461734e-01 0.609 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.784248e-01 0.422 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.784248e-01 0.422 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.420223e-01 0.848 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.921495e-01 0.716 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.647766e-01 0.577 0 0
Signaling by AXIN mutants R-HSA-4839735 2.647766e-01 0.577 0 0
MET interacts with TNS proteins R-HSA-8875513 4.481017e-01 0.349 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.481017e-01 0.349 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 3.758541e-01 0.425 0 0
mTORC1-mediated signalling R-HSA-166208 2.424342e-01 0.615 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 3.289068e-01 0.483 0 0
Reproduction R-HSA-1474165 7.439021e-02 1.128 0 0
Kinesins R-HSA-983189 1.919724e-01 0.717 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.572525e-01 0.340 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 4.572525e-01 0.340 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 4.572525e-01 0.340 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 4.243838e-01 0.372 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.995703e-01 0.398 0 0
Ionotropic activity of kainate receptors R-HSA-451306 4.955947e-01 0.305 0 0
Bicarbonate transporters R-HSA-425381 4.955947e-01 0.305 0 0
Reelin signalling pathway R-HSA-8866376 5.649089e-01 0.248 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 2.946555e-01 0.531 0 0
Budding and maturation of HIV virion R-HSA-162588 4.484847e-01 0.348 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 5.321646e-01 0.274 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 5.147403e-01 0.288 0 0
Signaling by VEGF R-HSA-194138 4.012438e-01 0.397 0 0
G2/M Transition R-HSA-69275 3.964963e-01 0.402 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 5.155805e-01 0.288 0 0
VLDLR internalisation and degradation R-HSA-8866427 5.668775e-01 0.247 0 0
NGF-independant TRKA activation R-HSA-187024 6.136900e-01 0.212 0 0
Phosphorylation of Emi1 R-HSA-176417 6.136900e-01 0.212 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 6.136900e-01 0.212 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.136900e-01 0.212 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.136900e-01 0.212 0 0
Cristae formation R-HSA-8949613 5.514077e-01 0.259 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 5.974019e-01 0.224 0 0
Mitochondrial calcium ion transport R-HSA-8949215 6.222273e-01 0.206 0 0
HIV Life Cycle R-HSA-162587 3.425735e-01 0.465 0 0
HIV Infection R-HSA-162906 5.517558e-01 0.258 0 0
Signaling by MET R-HSA-6806834 5.985794e-01 0.223 0 0
Interleukin-1 family signaling R-HSA-446652 3.734679e-01 0.428 0 0
Mitotic G2-G2/M phases R-HSA-453274 4.154147e-01 0.382 0 0
MAPK family signaling cascades R-HSA-5683057 2.709962e-01 0.567 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 5.751217e-01 0.240 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 4.172571e-01 0.380 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 4.521499e-01 0.345 0 0
FLT3 signaling in disease R-HSA-9682385 2.540391e-01 0.595 0 0
GPVI-mediated activation cascade R-HSA-114604 5.790128e-01 0.237 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 4.539137e-01 0.343 0 0
MyD88-independent TLR4 cascade R-HSA-166166 2.883490e-01 0.540 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 2.883490e-01 0.540 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 5.003421e-01 0.301 0 0
Signaling by FGFR4 in disease R-HSA-5655291 6.305926e-01 0.200 0 0
Signaling by FGFR in disease R-HSA-1226099 3.851990e-01 0.414 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.496926e-01 0.603 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 4.572525e-01 0.340 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.409351e-01 0.467 0 0
Signaling by TGFB family members R-HSA-9006936 2.951386e-01 0.530 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.719755e-01 0.565 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.504745e-01 0.346 0 0
Neurodegenerative Diseases R-HSA-8863678 1.510219e-01 0.821 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.510219e-01 0.821 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.776087e-01 0.321 0 0
Response of endothelial cells to shear stress R-HSA-9860931 6.088240e-01 0.216 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.762286e-01 0.425 0 0
Amine ligand-binding receptors R-HSA-375280 1.716508e-01 0.765 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.203036e-01 0.494 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 5.514077e-01 0.259 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 5.887141e-01 0.230 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.353995e-01 0.628 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 9.233708e-02 1.035 0 0
FLT3 Signaling R-HSA-9607240 3.464037e-01 0.460 0 0
Macroautophagy R-HSA-1632852 6.031951e-01 0.220 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.062890e-01 0.974 0 0
TRP channels R-HSA-3295583 9.101672e-02 1.041 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.921495e-01 0.716 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 4.552580e-01 0.342 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.026886e-01 0.693 0 0
HDMs demethylate histones R-HSA-3214842 1.675451e-01 0.776 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 8.524630e-02 1.069 0 0
Heme signaling R-HSA-9707616 8.000605e-02 1.097 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.758541e-01 0.425 0 0
Interleukin-1 processing R-HSA-448706 4.172731e-01 0.380 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 4.172731e-01 0.380 0 0
Regulated proteolysis of p75NTR R-HSA-193692 4.172731e-01 0.380 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.003576e-01 0.698 0 0
Synthesis of PG R-HSA-1483148 4.552580e-01 0.342 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.649089e-01 0.248 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.752065e-01 0.560 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.136900e-01 0.212 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 6.136900e-01 0.212 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.996903e-01 0.222 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 6.305926e-01 0.200 0 0
CRMPs in Sema3A signaling R-HSA-399956 6.305926e-01 0.200 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.686330e-01 0.329 0 0
Signaling by PTK6 R-HSA-8848021 4.686330e-01 0.329 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 5.969370e-01 0.224 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 5.969370e-01 0.224 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 4.854138e-01 0.314 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 4.854138e-01 0.314 0 0
The NLRP3 inflammasome R-HSA-844456 5.431474e-01 0.265 0 0
Signaling by Interleukins R-HSA-449147 4.596982e-01 0.338 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.332692e-01 0.477 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 2.402169e-01 0.619 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.996903e-01 0.222 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.998227e-01 0.523 0 0
Signaling by Leptin R-HSA-2586552 2.025294e-01 0.694 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 4.298890e-01 0.367 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.933257e-01 0.533 0 0
TBC/RABGAPs R-HSA-8854214 5.644710e-01 0.248 0 0
Interleukin-6 signaling R-HSA-1059683 5.996903e-01 0.222 0 0
MAP kinase activation R-HSA-450294 2.041859e-01 0.690 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 1.200071e-01 0.921 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.999565e-01 0.523 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.999565e-01 0.523 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 2.027474e-01 0.693 0 0
DSCAM interactions R-HSA-376172 3.784248e-01 0.422 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.420223e-01 0.848 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.481017e-01 0.349 0 0
Sensory perception of sour taste R-HSA-9729555 5.099716e-01 0.292 0 0
NADE modulates death signalling R-HSA-205025 5.099716e-01 0.292 0 0
Protein methylation R-HSA-8876725 3.929246e-01 0.406 0 0
NOD1/2 Signaling Pathway R-HSA-168638 3.617831e-01 0.442 0 0
PTK6 Down-Regulation R-HSA-8849472 5.649089e-01 0.248 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 5.649089e-01 0.248 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 5.649089e-01 0.248 0 0
Mitochondrial biogenesis R-HSA-1592230 3.006475e-01 0.522 0 0
Signaling by SCF-KIT R-HSA-1433557 4.036466e-01 0.394 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.136900e-01 0.212 0 0
Maturation of nucleoprotein R-HSA-9683610 5.996903e-01 0.222 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 5.969370e-01 0.224 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 6.193439e-01 0.208 0 0
Diseases of DNA repair R-HSA-9675135 1.985182e-01 0.702 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.604764e-01 0.795 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.559859e-01 0.449 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 3.995703e-01 0.398 0 0
Interleukin-17 signaling R-HSA-448424 3.263791e-01 0.486 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 3.704174e-01 0.431 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.496926e-01 0.603 0 0
Nephrin family interactions R-HSA-373753 3.463773e-01 0.460 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 6.136900e-01 0.212 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 5.996903e-01 0.222 0 0
Histamine receptors R-HSA-390650 4.481017e-01 0.349 0 0
Tie2 Signaling R-HSA-210993 5.147403e-01 0.288 0 0
Selenocysteine synthesis R-HSA-2408557 4.613666e-01 0.336 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 6.151521e-01 0.211 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.850150e-01 0.314 0 0
Formation of the nephric duct R-HSA-9830364 5.027774e-01 0.299 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 4.935577e-01 0.307 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 1.200071e-01 0.921 0 0
NrCAM interactions R-HSA-447038 2.027474e-01 0.693 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.784248e-01 0.422 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.784248e-01 0.422 0 0
Interleukin-18 signaling R-HSA-9012546 3.758541e-01 0.425 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 5.649089e-01 0.248 0 0
SARS-CoV-1-host interactions R-HSA-9692914 4.322713e-01 0.364 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.136900e-01 0.212 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 6.136900e-01 0.212 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 5.003421e-01 0.301 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 5.996903e-01 0.222 0 0
Potential therapeutics for SARS R-HSA-9679191 6.167864e-01 0.210 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.728454e-01 0.762 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 4.259188e-01 0.371 0 0
Interleukin-2 signaling R-HSA-9020558 4.955947e-01 0.305 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.921495e-01 0.716 0 0
FasL/ CD95L signaling R-HSA-75157 4.481017e-01 0.349 0 0
Lipophagy R-HSA-9613354 4.172731e-01 0.380 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 4.955947e-01 0.305 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 5.649089e-01 0.248 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 6.136900e-01 0.212 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 6.222273e-01 0.206 0 0
Stimuli-sensing channels R-HSA-2672351 5.636560e-01 0.249 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.933257e-01 0.533 0 0
Nephron development R-HSA-9831926 5.147403e-01 0.288 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 2.164442e-01 0.665 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 6.136900e-01 0.212 0 0
TRAIL signaling R-HSA-75158 6.136900e-01 0.212 0 0
Interleukin-12 family signaling R-HSA-447115 5.885916e-01 0.230 0 0
Interleukin-37 signaling R-HSA-9008059 1.414857e-01 0.849 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 5.649089e-01 0.248 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.699914e-01 0.432 0 0
OAS antiviral response R-HSA-8983711 5.668775e-01 0.247 0 0
Response to metal ions R-HSA-5660526 4.552580e-01 0.342 0 0
XBP1(S) activates chaperone genes R-HSA-381038 4.556122e-01 0.341 0 0
Regulation of KIT signaling R-HSA-1433559 6.305926e-01 0.200 0 0
Non-canonical inflammasome activation R-HSA-9686114 6.305926e-01 0.200 0 0
IRE1alpha activates chaperones R-HSA-381070 5.393181e-01 0.268 0 0
SARS-CoV-1 Infection R-HSA-9678108 5.331334e-01 0.273 0 0
Interleukin-12 signaling R-HSA-9020591 5.404179e-01 0.267 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 2.933257e-01 0.533 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 4.259188e-01 0.371 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 6.352616e-01 0.197 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 6.367359e-01 0.196 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 6.367359e-01 0.196 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 6.367479e-01 0.196 0 0
Cellular response to heat stress R-HSA-3371556 6.375435e-01 0.195 0 0
Stabilization of p53 R-HSA-69541 6.377338e-01 0.195 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 6.404515e-01 0.194 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 6.404515e-01 0.194 0 0
EGFR downregulation R-HSA-182971 6.404515e-01 0.194 0 0
Signaling by FGFR R-HSA-190236 6.430054e-01 0.192 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 6.464102e-01 0.189 0 0
Notch-HLH transcription pathway R-HSA-350054 6.464102e-01 0.189 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 6.464102e-01 0.189 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 6.464102e-01 0.189 0 0
LDL clearance R-HSA-8964038 6.464102e-01 0.189 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 6.504027e-01 0.187 0 0
IRS-mediated signalling R-HSA-112399 6.524696e-01 0.185 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 6.530142e-01 0.185 0 0
Intraflagellar transport R-HSA-5620924 6.536482e-01 0.185 0 0
Co-stimulation by CD28 R-HSA-389356 6.536482e-01 0.185 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 6.561398e-01 0.183 0 0
Diseases of Immune System R-HSA-5260271 6.561398e-01 0.183 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 6.561398e-01 0.183 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.570044e-01 0.182 0 0
STAT5 Activation R-HSA-9645135 6.570044e-01 0.182 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 6.570044e-01 0.182 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.570044e-01 0.182 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 6.570044e-01 0.182 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.570044e-01 0.182 0 0
CREB phosphorylation R-HSA-199920 6.570044e-01 0.182 0 0
NADPH regeneration R-HSA-389542 6.570044e-01 0.182 0 0
Lipid particle organization R-HSA-8964572 6.570044e-01 0.182 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 6.592638e-01 0.181 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 6.596004e-01 0.181 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.596004e-01 0.181 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 6.596004e-01 0.181 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 6.596004e-01 0.181 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 6.596004e-01 0.181 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.596004e-01 0.181 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 6.596004e-01 0.181 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 6.596004e-01 0.181 0 0
Signaling by WNT in cancer R-HSA-4791275 6.608100e-01 0.180 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 6.657503e-01 0.177 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 6.677789e-01 0.175 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 6.677789e-01 0.175 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 6.677789e-01 0.175 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 6.694730e-01 0.174 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 6.694730e-01 0.174 0 0
Syndecan interactions R-HSA-3000170 6.694730e-01 0.174 0 0
Growth hormone receptor signaling R-HSA-982772 6.694730e-01 0.174 0 0
Degradation of CDH1 R-HSA-9766229 6.700671e-01 0.174 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 6.739345e-01 0.171 0 0
Autophagy R-HSA-9612973 6.751362e-01 0.171 0 0
Interleukin-1 signaling R-HSA-9020702 6.785256e-01 0.168 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 6.803717e-01 0.167 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 6.803717e-01 0.167 0 0
Regulation of necroptotic cell death R-HSA-5675482 6.803717e-01 0.167 0 0
PI3K Cascade R-HSA-109704 6.859819e-01 0.164 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.867499e-01 0.163 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.867499e-01 0.163 0 0
Phosphorylation of the APC/C R-HSA-176412 6.867499e-01 0.163 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 6.867499e-01 0.163 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 6.867499e-01 0.163 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.867499e-01 0.163 0 0
Killing mechanisms R-HSA-9664420 6.867499e-01 0.163 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.867499e-01 0.163 0 0
Phase 4 - resting membrane potential R-HSA-5576886 6.867499e-01 0.163 0 0
Regulation of BACH1 activity R-HSA-9708530 6.867499e-01 0.163 0 0
Negative regulation of FLT3 R-HSA-9706369 6.867499e-01 0.163 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.867499e-01 0.163 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 6.867499e-01 0.163 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 6.867499e-01 0.163 0 0
Rab regulation of trafficking R-HSA-9007101 6.900794e-01 0.161 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 6.902408e-01 0.161 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 6.911076e-01 0.160 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 6.911076e-01 0.160 0 0
Intra-Golgi traffic R-HSA-6811438 6.911076e-01 0.160 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 6.914133e-01 0.160 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 6.914133e-01 0.160 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.914133e-01 0.160 0 0
PCP/CE pathway R-HSA-4086400 6.922487e-01 0.160 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 6.954645e-01 0.158 0 0
Netrin mediated repulsion signals R-HSA-418886 6.954645e-01 0.158 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.954645e-01 0.158 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.954645e-01 0.158 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.954645e-01 0.158 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 6.954645e-01 0.158 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.954645e-01 0.158 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.954645e-01 0.158 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.954645e-01 0.158 0 0
Ca2+ activated K+ channels R-HSA-1296052 6.954645e-01 0.158 0 0
VLDL clearance R-HSA-8964046 6.954645e-01 0.158 0 0
Activation of TRKA receptors R-HSA-187015 6.954645e-01 0.158 0 0
Regulation of PTEN localization R-HSA-8948747 6.954645e-01 0.158 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.954645e-01 0.158 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 6.971213e-01 0.157 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 6.971213e-01 0.157 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 6.971213e-01 0.157 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 6.971213e-01 0.157 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 6.971213e-01 0.157 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 6.971213e-01 0.157 0 0
Effects of PIP2 hydrolysis R-HSA-114508 6.991294e-01 0.155 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 6.991294e-01 0.155 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.013848e-01 0.154 0 0
HSF1-dependent transactivation R-HSA-3371571 7.013848e-01 0.154 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.018150e-01 0.154 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 7.074868e-01 0.150 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 7.120931e-01 0.147 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 7.120931e-01 0.147 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 7.120931e-01 0.147 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 7.120931e-01 0.147 0 0
Interleukin-7 signaling R-HSA-1266695 7.122375e-01 0.147 0 0
Diseases of programmed cell death R-HSA-9645723 7.148297e-01 0.146 0 0
Selective autophagy R-HSA-9663891 7.148297e-01 0.146 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 7.170817e-01 0.144 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 7.170817e-01 0.144 0 0
Nuclear import of Rev protein R-HSA-180746 7.170817e-01 0.144 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 7.171843e-01 0.144 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 7.235659e-01 0.141 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 7.247181e-01 0.140 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 7.288584e-01 0.137 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 7.296141e-01 0.137 0 0
Activation of RAS in B cells R-HSA-1169092 7.296141e-01 0.137 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 7.296141e-01 0.137 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.296141e-01 0.137 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 7.296141e-01 0.137 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.296141e-01 0.137 0 0
Interleukin-23 signaling R-HSA-9020933 7.296141e-01 0.137 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.296141e-01 0.137 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.296141e-01 0.137 0 0
Interleukin-9 signaling R-HSA-8985947 7.296141e-01 0.137 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 7.296141e-01 0.137 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.296141e-01 0.137 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 7.296141e-01 0.137 0 0
Alpha-defensins R-HSA-1462054 7.296141e-01 0.137 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.296141e-01 0.137 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 7.306352e-01 0.136 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 7.306352e-01 0.136 0 0
Metalloprotease DUBs R-HSA-5689901 7.319598e-01 0.136 0 0
Signaling by EGFR in Cancer R-HSA-1643713 7.319598e-01 0.136 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.319598e-01 0.136 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.319598e-01 0.136 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 7.328936e-01 0.135 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 7.328936e-01 0.135 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 7.342315e-01 0.134 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 7.342315e-01 0.134 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.342315e-01 0.134 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 7.342315e-01 0.134 0 0
Telomere Maintenance R-HSA-157579 7.348967e-01 0.134 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 7.356937e-01 0.133 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 7.356937e-01 0.133 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.356937e-01 0.133 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 7.356937e-01 0.133 0 0
Uptake and function of anthrax toxins R-HSA-5210891 7.356937e-01 0.133 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 7.388480e-01 0.131 0 0
G1 Phase R-HSA-69236 7.388480e-01 0.131 0 0
Cyclin D associated events in G1 R-HSA-69231 7.388480e-01 0.131 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 7.505861e-01 0.125 0 0
PRC2 methylates histones and DNA R-HSA-212300 7.505861e-01 0.125 0 0
Calmodulin induced events R-HSA-111933 7.505861e-01 0.125 0 0
CaM pathway R-HSA-111997 7.505861e-01 0.125 0 0
RUNX2 regulates bone development R-HSA-8941326 7.505861e-01 0.125 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.506007e-01 0.125 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 7.506007e-01 0.125 0 0
Interaction between L1 and Ankyrins R-HSA-445095 7.506007e-01 0.125 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 7.506007e-01 0.125 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 7.535015e-01 0.123 0 0
DAG and IP3 signaling R-HSA-1489509 7.535015e-01 0.123 0 0
Signaling by ERBB4 R-HSA-1236394 7.567524e-01 0.121 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 7.576237e-01 0.121 0 0
PKA activation in glucagon signalling R-HSA-164378 7.576237e-01 0.121 0 0
PKA activation R-HSA-163615 7.576237e-01 0.121 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 7.576237e-01 0.121 0 0
Apoptotic factor-mediated response R-HSA-111471 7.576237e-01 0.121 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.599360e-01 0.119 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.599360e-01 0.119 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.599360e-01 0.119 0 0
Unwinding of DNA R-HSA-176974 7.599360e-01 0.119 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.599360e-01 0.119 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 7.599360e-01 0.119 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.599360e-01 0.119 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.599360e-01 0.119 0 0
Cellular response to mitochondrial stress R-HSA-9840373 7.599360e-01 0.119 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 7.599360e-01 0.119 0 0
Cellular response to hypoxia R-HSA-1234174 7.627875e-01 0.118 0 0
Degradation of DVL R-HSA-4641258 7.661563e-01 0.116 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 7.661563e-01 0.116 0 0
ISG15 antiviral mechanism R-HSA-1169408 7.681000e-01 0.115 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 7.681861e-01 0.115 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 7.681861e-01 0.115 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 7.681861e-01 0.115 0 0
Inflammasomes R-HSA-622312 7.681861e-01 0.115 0 0
L1CAM interactions R-HSA-373760 7.691726e-01 0.114 0 0
Cellular response to starvation R-HSA-9711097 7.692319e-01 0.114 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 7.706091e-01 0.113 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 7.706091e-01 0.113 0 0
Translesion Synthesis by POLH R-HSA-110320 7.779609e-01 0.109 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.779609e-01 0.109 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 7.779609e-01 0.109 0 0
Maturation of nucleoprotein R-HSA-9694631 7.779609e-01 0.109 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 7.809562e-01 0.107 0 0
MET promotes cell motility R-HSA-8875878 7.809562e-01 0.107 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 7.809562e-01 0.107 0 0
Regulation of CDH1 Function R-HSA-9764561 7.829033e-01 0.106 0 0
PI Metabolism R-HSA-1483255 7.844316e-01 0.105 0 0
DNA methylation R-HSA-5334118 7.847460e-01 0.105 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 7.847460e-01 0.105 0 0
Platelet calcium homeostasis R-HSA-418360 7.847460e-01 0.105 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 7.858812e-01 0.105 0 0
Kidney development R-HSA-9830369 7.859558e-01 0.105 0 0
2-LTR circle formation R-HSA-164843 7.868591e-01 0.104 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.868591e-01 0.104 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 7.868591e-01 0.104 0 0
Arachidonate production from DAG R-HSA-426048 7.868591e-01 0.104 0 0
Interleukin-27 signaling R-HSA-9020956 7.868591e-01 0.104 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.868591e-01 0.104 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 7.868591e-01 0.104 0 0
Josephin domain DUBs R-HSA-5689877 7.868591e-01 0.104 0 0
Tandem pore domain potassium channels R-HSA-1296346 7.868591e-01 0.104 0 0
GPER1 signaling R-HSA-9634597 7.937555e-01 0.100 0 0
Metal ion SLC transporters R-HSA-425410 7.937555e-01 0.100 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 7.950024e-01 0.100 0 0
Influenza Infection R-HSA-168255 7.959472e-01 0.099 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 7.967868e-01 0.099 0 0
Formation of definitive endoderm R-HSA-9823730 7.967868e-01 0.099 0 0
Signaling by NODAL R-HSA-1181150 7.967868e-01 0.099 0 0
Protein hydroxylation R-HSA-9629569 7.967868e-01 0.099 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 7.968861e-01 0.099 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 8.003138e-01 0.097 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.083139e-01 0.092 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 8.083139e-01 0.092 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 8.083139e-01 0.092 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 8.083139e-01 0.092 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 8.083139e-01 0.092 0 0
Sensory processing of sound R-HSA-9659379 8.096565e-01 0.092 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 8.107642e-01 0.091 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 8.107642e-01 0.091 0 0
LGI-ADAM interactions R-HSA-5682910 8.107642e-01 0.091 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 8.107642e-01 0.091 0 0
Transport of RCbl within the body R-HSA-9758890 8.107642e-01 0.091 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.107642e-01 0.091 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.107642e-01 0.091 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 8.107642e-01 0.091 0 0
Suppression of apoptosis R-HSA-9635465 8.107642e-01 0.091 0 0
Toll-like Receptor Cascades R-HSA-168898 8.141551e-01 0.089 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.141844e-01 0.089 0 0
Signalling to RAS R-HSA-167044 8.141844e-01 0.089 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 8.141844e-01 0.089 0 0
Lagging Strand Synthesis R-HSA-69186 8.141844e-01 0.089 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 8.141844e-01 0.089 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 8.141844e-01 0.089 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 8.141844e-01 0.089 0 0
Early Phase of HIV Life Cycle R-HSA-162594 8.141844e-01 0.089 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.149258e-01 0.089 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 8.149258e-01 0.089 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.149258e-01 0.089 0 0
COPI-mediated anterograde transport R-HSA-6807878 8.156337e-01 0.089 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 8.209115e-01 0.086 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 8.209115e-01 0.086 0 0
Maturation of spike protein R-HSA-9694548 8.209115e-01 0.086 0 0
PLC beta mediated events R-HSA-112043 8.271010e-01 0.082 0 0
DNA strand elongation R-HSA-69190 8.286199e-01 0.082 0 0
Hedgehog ligand biogenesis R-HSA-5358346 8.286680e-01 0.082 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 8.302372e-01 0.081 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.302372e-01 0.081 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 8.302372e-01 0.081 0 0
Attachment and Entry R-HSA-9694614 8.302372e-01 0.081 0 0
Assembly Of The HIV Virion R-HSA-175474 8.302372e-01 0.081 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 8.319894e-01 0.080 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.319894e-01 0.080 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.319894e-01 0.080 0 0
Sodium/Calcium exchangers R-HSA-425561 8.319894e-01 0.080 0 0
Integration of provirus R-HSA-162592 8.319894e-01 0.080 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 8.319894e-01 0.080 0 0
Post-translational protein phosphorylation R-HSA-8957275 8.321423e-01 0.080 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 8.328177e-01 0.079 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.328177e-01 0.079 0 0
HIV Transcription Initiation R-HSA-167161 8.328177e-01 0.079 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.328177e-01 0.079 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.328177e-01 0.079 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.328177e-01 0.079 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.328177e-01 0.079 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.342853e-01 0.079 0 0
SARS-CoV Infections R-HSA-9679506 8.364203e-01 0.078 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 8.391813e-01 0.076 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.391813e-01 0.076 0 0
Defective B3GALTL causes PpS R-HSA-5083635 8.414354e-01 0.075 0 0
Activation of ATR in response to replication stress R-HSA-176187 8.414354e-01 0.075 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 8.414354e-01 0.075 0 0
rRNA processing R-HSA-72312 8.427487e-01 0.074 0 0
Ca-dependent events R-HSA-111996 8.440559e-01 0.074 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 8.440559e-01 0.074 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.450280e-01 0.073 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 8.450280e-01 0.073 0 0
Signaling by KIT in disease R-HSA-9669938 8.450280e-01 0.073 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 8.450280e-01 0.073 0 0
Ca2+ pathway R-HSA-4086398 8.452442e-01 0.073 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.452860e-01 0.073 0 0
Glycolysis R-HSA-70171 8.474898e-01 0.072 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 8.508351e-01 0.070 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 8.508351e-01 0.070 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 8.508351e-01 0.070 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.508351e-01 0.070 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 8.508351e-01 0.070 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.508351e-01 0.070 0 0
Polymerase switching R-HSA-69091 8.508351e-01 0.070 0 0
Leading Strand Synthesis R-HSA-69109 8.508351e-01 0.070 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.508351e-01 0.070 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.508351e-01 0.070 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 8.508351e-01 0.070 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 8.508351e-01 0.070 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 8.508351e-01 0.070 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 8.508351e-01 0.070 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.508351e-01 0.070 0 0
Estrogen biosynthesis R-HSA-193144 8.508351e-01 0.070 0 0
Interleukin-35 Signalling R-HSA-8984722 8.508351e-01 0.070 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 8.534124e-01 0.069 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.534124e-01 0.069 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.546505e-01 0.068 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 8.546505e-01 0.068 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 8.586171e-01 0.066 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 8.586379e-01 0.066 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 8.586379e-01 0.066 0 0
Carnitine shuttle R-HSA-200425 8.586379e-01 0.066 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 8.610019e-01 0.065 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.618017e-01 0.065 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 8.645913e-01 0.063 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.645913e-01 0.063 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 8.645913e-01 0.063 0 0
RMTs methylate histone arginines R-HSA-3214858 8.646266e-01 0.063 0 0
DAP12 interactions R-HSA-2172127 8.646266e-01 0.063 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.675678e-01 0.062 0 0
Processing of SMDT1 R-HSA-8949664 8.675678e-01 0.062 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.675678e-01 0.062 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 8.675678e-01 0.062 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.675678e-01 0.062 0 0
Chylomicron remodeling R-HSA-8963901 8.675678e-01 0.062 0 0
Mtb iron assimilation by chelation R-HSA-1222449 8.675678e-01 0.062 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.675678e-01 0.062 0 0
Formation of axial mesoderm R-HSA-9796292 8.675678e-01 0.062 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.675678e-01 0.062 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 8.675678e-01 0.062 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.675678e-01 0.062 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.675678e-01 0.062 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.675678e-01 0.062 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 8.675740e-01 0.062 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 8.683618e-01 0.061 0 0
Inositol phosphate metabolism R-HSA-1483249 8.692352e-01 0.061 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 8.695212e-01 0.061 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 8.711455e-01 0.060 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 8.711455e-01 0.060 0 0
Interleukin-6 family signaling R-HSA-6783589 8.711455e-01 0.060 0 0
TNFs bind their physiological receptors R-HSA-5669034 8.711455e-01 0.060 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.740096e-01 0.058 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 8.740096e-01 0.058 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 8.740096e-01 0.058 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 8.740096e-01 0.058 0 0
Developmental Biology R-HSA-1266738 8.746407e-01 0.058 0 0
Opioid Signalling R-HSA-111885 8.748621e-01 0.058 0 0
Regulation of Apoptosis R-HSA-169911 8.750126e-01 0.058 0 0
Oncogene Induced Senescence R-HSA-2559585 8.750126e-01 0.058 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 8.752178e-01 0.058 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 8.754007e-01 0.058 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 8.760472e-01 0.057 0 0
Cellular responses to stimuli R-HSA-8953897 8.768117e-01 0.057 0 0
G-protein mediated events R-HSA-112040 8.795927e-01 0.056 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.821383e-01 0.054 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.824244e-01 0.054 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 8.824244e-01 0.054 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 8.824244e-01 0.054 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 8.824244e-01 0.054 0 0
NRIF signals cell death from the nucleus R-HSA-205043 8.824244e-01 0.054 0 0
HDL assembly R-HSA-8963896 8.824244e-01 0.054 0 0
Signal regulatory protein family interactions R-HSA-391160 8.824244e-01 0.054 0 0
Zinc transporters R-HSA-435354 8.824244e-01 0.054 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.824244e-01 0.054 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.826270e-01 0.054 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 8.826270e-01 0.054 0 0
Tight junction interactions R-HSA-420029 8.826270e-01 0.054 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 8.826270e-01 0.054 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.826270e-01 0.054 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.826270e-01 0.054 0 0
Hyaluronan degradation R-HSA-2160916 8.826270e-01 0.054 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.828251e-01 0.054 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.828251e-01 0.054 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 8.828251e-01 0.054 0 0
RNA Polymerase I Transcription R-HSA-73864 8.838943e-01 0.054 0 0
G1/S-Specific Transcription R-HSA-69205 8.847161e-01 0.053 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 8.868897e-01 0.052 0 0
Cellular responses to stress R-HSA-2262752 8.879942e-01 0.052 0 0
Cardiac conduction R-HSA-5576891 8.882445e-01 0.051 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 8.931550e-01 0.049 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 8.931550e-01 0.049 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.931550e-01 0.049 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 8.937414e-01 0.049 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.937414e-01 0.049 0 0
Degradation of AXIN R-HSA-4641257 8.937414e-01 0.049 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.937414e-01 0.049 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.956151e-01 0.048 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.956151e-01 0.048 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 8.956151e-01 0.048 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.956151e-01 0.048 0 0
Translesion synthesis by REV1 R-HSA-110312 8.956151e-01 0.048 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.956151e-01 0.048 0 0
Protein lipoylation R-HSA-9857492 8.956151e-01 0.048 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 8.956151e-01 0.048 0 0
Biotin transport and metabolism R-HSA-196780 8.956151e-01 0.048 0 0
Processive synthesis on the lagging strand R-HSA-69183 8.956151e-01 0.048 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.961610e-01 0.048 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 8.987462e-01 0.046 0 0
G1/S Transition R-HSA-69206 9.027021e-01 0.044 0 0
Packaging Of Telomere Ends R-HSA-171306 9.027989e-01 0.044 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 9.027989e-01 0.044 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.027989e-01 0.044 0 0
Signaling by BMP R-HSA-201451 9.027989e-01 0.044 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 9.033321e-01 0.044 0 0
Regulation of mitotic cell cycle R-HSA-453276 9.065663e-01 0.043 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 9.065663e-01 0.043 0 0
Translesion synthesis by POLI R-HSA-5656121 9.073266e-01 0.042 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.073266e-01 0.042 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.073266e-01 0.042 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.073266e-01 0.042 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.073266e-01 0.042 0 0
Activation of SMO R-HSA-5635838 9.073266e-01 0.042 0 0
Attachment and Entry R-HSA-9678110 9.073266e-01 0.042 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 9.086827e-01 0.042 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 9.098634e-01 0.041 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.099097e-01 0.041 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.099097e-01 0.041 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.116246e-01 0.040 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.116246e-01 0.040 0 0
Pyrimidine salvage R-HSA-73614 9.116246e-01 0.040 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 9.116246e-01 0.040 0 0
Viral Messenger RNA Synthesis R-HSA-168325 9.117942e-01 0.040 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.117942e-01 0.040 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.129201e-01 0.040 0 0
PPARA activates gene expression R-HSA-1989781 9.163085e-01 0.038 0 0
Signaling by Insulin receptor R-HSA-74752 9.164353e-01 0.038 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.164353e-01 0.038 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 9.171265e-01 0.038 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 9.171265e-01 0.038 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 9.171265e-01 0.038 0 0
Glycogen metabolism R-HSA-8982491 9.171265e-01 0.038 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.175511e-01 0.037 0 0
Muscle contraction R-HSA-397014 9.175511e-01 0.037 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.177248e-01 0.037 0 0
Translesion synthesis by POLK R-HSA-5655862 9.177248e-01 0.037 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 9.177248e-01 0.037 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.177248e-01 0.037 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.177248e-01 0.037 0 0
Glycine degradation R-HSA-6783984 9.177248e-01 0.037 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.177248e-01 0.037 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 9.177248e-01 0.037 0 0
Vitamin B6 activation to pyridoxal phosphate R-HSA-964975 9.177248e-01 0.037 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 9.177248e-01 0.037 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 9.177248e-01 0.037 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 9.177248e-01 0.037 0 0
Fibronectin matrix formation R-HSA-1566977 9.177248e-01 0.037 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 9.177248e-01 0.037 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.177248e-01 0.037 0 0
tRNA processing in the nucleus R-HSA-6784531 9.177469e-01 0.037 0 0
mRNA Capping R-HSA-72086 9.196941e-01 0.036 0 0
Termination of translesion DNA synthesis R-HSA-5656169 9.196941e-01 0.036 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.212304e-01 0.036 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.238121e-01 0.034 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.238121e-01 0.034 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.238121e-01 0.034 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.238121e-01 0.034 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.238121e-01 0.034 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 9.238121e-01 0.034 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.250119e-01 0.034 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.252137e-01 0.034 0 0
Orc1 removal from chromatin R-HSA-68949 9.252137e-01 0.034 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 9.269568e-01 0.033 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 9.269568e-01 0.033 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 9.269568e-01 0.033 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.269568e-01 0.033 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.269568e-01 0.033 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 9.269568e-01 0.033 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.269568e-01 0.033 0 0
Glycogen storage diseases R-HSA-3229121 9.269568e-01 0.033 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.269568e-01 0.033 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.269568e-01 0.033 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.269568e-01 0.033 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 9.270661e-01 0.033 0 0
Activation of BH3-only proteins R-HSA-114452 9.270661e-01 0.033 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.270661e-01 0.033 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.275113e-01 0.033 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.287878e-01 0.032 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.300001e-01 0.032 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.307549e-01 0.031 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 9.325979e-01 0.030 0 0
UCH proteinases R-HSA-5689603 9.328108e-01 0.030 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.337954e-01 0.030 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.337954e-01 0.030 0 0
Cargo concentration in the ER R-HSA-5694530 9.337954e-01 0.030 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.337954e-01 0.030 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.339235e-01 0.030 0 0
Ion channel transport R-HSA-983712 9.341797e-01 0.030 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.351534e-01 0.029 0 0
Transport of connexons to the plasma membrane R-HSA-190872 9.351534e-01 0.029 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.351534e-01 0.029 0 0
Chaperone Mediated Autophagy R-HSA-9613829 9.351534e-01 0.029 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.351534e-01 0.029 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.351534e-01 0.029 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.351534e-01 0.029 0 0
Platelet sensitization by LDL R-HSA-432142 9.351534e-01 0.029 0 0
GAB1 signalosome R-HSA-180292 9.351534e-01 0.029 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.357225e-01 0.029 0 0
Depyrimidination R-HSA-73928 9.357225e-01 0.029 0 0
Host Interactions of HIV factors R-HSA-162909 9.361370e-01 0.029 0 0
Translation of Structural Proteins R-HSA-9694635 9.371989e-01 0.028 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.397091e-01 0.027 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.399334e-01 0.027 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.399334e-01 0.027 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.399334e-01 0.027 0 0
Signaling by NOTCH3 R-HSA-9012852 9.407367e-01 0.027 0 0
Integrin cell surface interactions R-HSA-216083 9.413303e-01 0.026 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 9.424306e-01 0.026 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.424306e-01 0.026 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 9.424306e-01 0.026 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.424306e-01 0.026 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.424306e-01 0.026 0 0
Diseases of hemostasis R-HSA-9671793 9.424306e-01 0.026 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.424306e-01 0.026 0 0
Other interleukin signaling R-HSA-449836 9.424306e-01 0.026 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.424306e-01 0.026 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.427361e-01 0.026 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.427361e-01 0.026 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.427361e-01 0.026 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 9.452193e-01 0.024 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.455281e-01 0.024 0 0
Surfactant metabolism R-HSA-5683826 9.458919e-01 0.024 0 0
Glucose metabolism R-HSA-70326 9.473323e-01 0.023 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.478903e-01 0.023 0 0
Downstream TCR signaling R-HSA-202424 9.483938e-01 0.023 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.488915e-01 0.023 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.488915e-01 0.023 0 0
Co-inhibition by CTLA4 R-HSA-389513 9.488915e-01 0.023 0 0
Glycogen synthesis R-HSA-3322077 9.488915e-01 0.023 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.488915e-01 0.023 0 0
Signal transduction by L1 R-HSA-445144 9.488915e-01 0.023 0 0
Somitogenesis R-HSA-9824272 9.503958e-01 0.022 0 0
DNA Repair R-HSA-73894 9.505146e-01 0.022 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.506239e-01 0.022 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 9.506239e-01 0.022 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.506239e-01 0.022 0 0
Amyloid fiber formation R-HSA-977225 9.523057e-01 0.021 0 0
Dual incision in TC-NER R-HSA-6782135 9.532667e-01 0.021 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.545479e-01 0.020 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.545479e-01 0.020 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 9.546277e-01 0.020 0 0
G-protein activation R-HSA-202040 9.546277e-01 0.020 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.546277e-01 0.020 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.546277e-01 0.020 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.546277e-01 0.020 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.546277e-01 0.020 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.546277e-01 0.020 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.546277e-01 0.020 0 0
Basigin interactions R-HSA-210991 9.546277e-01 0.020 0 0
eNOS activation R-HSA-203615 9.552625e-01 0.020 0 0
Mitophagy R-HSA-5205647 9.552625e-01 0.020 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 9.552625e-01 0.020 0 0
Hyaluronan metabolism R-HSA-2142845 9.552625e-01 0.020 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.552625e-01 0.020 0 0
Signaling by NOTCH2 R-HSA-1980145 9.552625e-01 0.020 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.552625e-01 0.020 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.572081e-01 0.019 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 9.574792e-01 0.019 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.583730e-01 0.018 0 0
Cellular response to chemical stress R-HSA-9711123 9.589041e-01 0.018 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.594822e-01 0.018 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.594822e-01 0.018 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.597204e-01 0.018 0 0
Serine metabolism R-HSA-977347 9.597204e-01 0.018 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.602123e-01 0.018 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 9.603056e-01 0.018 0 0
Switching of origins to a post-replicative state R-HSA-69052 9.631962e-01 0.016 0 0
Collagen degradation R-HSA-1442490 9.633145e-01 0.016 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.633186e-01 0.016 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.633186e-01 0.016 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.633186e-01 0.016 0 0
Vesicle-mediated transport R-HSA-5653656 9.639059e-01 0.016 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.642417e-01 0.016 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.642417e-01 0.016 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.642417e-01 0.016 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.642417e-01 0.016 0 0
Ethanol oxidation R-HSA-71384 9.642417e-01 0.016 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.642417e-01 0.016 0 0
RSV-host interactions R-HSA-9833110 9.649588e-01 0.015 0 0
DNA Damage Bypass R-HSA-73893 9.651342e-01 0.015 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.657074e-01 0.015 0 0
Signaling by NOTCH4 R-HSA-9013694 9.658921e-01 0.015 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.661907e-01 0.015 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.661907e-01 0.015 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.661907e-01 0.015 0 0
Cleavage of the damaged purine R-HSA-110331 9.668046e-01 0.015 0 0
Collagen chain trimerization R-HSA-8948216 9.668046e-01 0.015 0 0
Metabolism of folate and pterines R-HSA-196757 9.668046e-01 0.015 0 0
Nucleotide Excision Repair R-HSA-5696398 9.671742e-01 0.014 0 0
Selenoamino acid metabolism R-HSA-2408522 9.679099e-01 0.014 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.682557e-01 0.014 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.682557e-01 0.014 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.682557e-01 0.014 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.682557e-01 0.014 0 0
Interleukin-20 family signaling R-HSA-8854691 9.682557e-01 0.014 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.682557e-01 0.014 0 0
Formation of the ureteric bud R-HSA-9830674 9.682557e-01 0.014 0 0
Biosynthesis of maresins R-HSA-9018682 9.682557e-01 0.014 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.684047e-01 0.014 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 9.688122e-01 0.014 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.699704e-01 0.013 0 0
Elastic fibre formation R-HSA-1566948 9.699704e-01 0.013 0 0
Depurination R-HSA-73927 9.699704e-01 0.013 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.699704e-01 0.013 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 9.708122e-01 0.013 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.708501e-01 0.013 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.708501e-01 0.013 0 0
Ion transport by P-type ATPases R-HSA-936837 9.713236e-01 0.013 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.718194e-01 0.012 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 9.718194e-01 0.012 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.718194e-01 0.012 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.718194e-01 0.012 0 0
Cytokine Signaling in Immune system R-HSA-1280215 9.719935e-01 0.012 0 0
Integration of energy metabolism R-HSA-163685 9.728375e-01 0.012 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.728441e-01 0.012 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 9.728441e-01 0.012 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.733636e-01 0.012 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.733636e-01 0.012 0 0
SARS-CoV-2-host interactions R-HSA-9705683 9.738481e-01 0.012 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.746848e-01 0.011 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.749832e-01 0.011 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.749832e-01 0.011 0 0
G protein gated Potassium channels R-HSA-1296059 9.749832e-01 0.011 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.749832e-01 0.011 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.749832e-01 0.011 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.749832e-01 0.011 0 0
ER-Phagosome pathway R-HSA-1236974 9.750038e-01 0.011 0 0
Attenuation phase R-HSA-3371568 9.754512e-01 0.011 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.754512e-01 0.011 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.756706e-01 0.011 0 0
Smooth Muscle Contraction R-HSA-445355 9.756706e-01 0.011 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.756706e-01 0.011 0 0
Co-inhibition by PD-1 R-HSA-389948 9.762178e-01 0.010 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.777867e-01 0.010 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.777867e-01 0.010 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 9.777919e-01 0.010 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.777919e-01 0.010 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.777919e-01 0.010 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.777919e-01 0.010 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.778154e-01 0.010 0 0
G alpha (s) signalling events R-HSA-418555 9.793403e-01 0.009 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.794765e-01 0.009 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.797267e-01 0.009 0 0
Translation of Structural Proteins R-HSA-9683701 9.799584e-01 0.009 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.802855e-01 0.009 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.802855e-01 0.009 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.802855e-01 0.009 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.802855e-01 0.009 0 0
Triglyceride biosynthesis R-HSA-75109 9.802855e-01 0.009 0 0
Synthesis of PE R-HSA-1483213 9.802855e-01 0.009 0 0
Insulin processing R-HSA-264876 9.802855e-01 0.009 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.814461e-01 0.008 0 0
Activation of GABAB receptors R-HSA-991365 9.819000e-01 0.008 0 0
GABA B receptor activation R-HSA-977444 9.819000e-01 0.008 0 0
Adaptive Immune System R-HSA-1280218 9.820544e-01 0.008 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 9.822629e-01 0.008 0 0
Iron assimilation using enterobactin R-HSA-9638334 9.824992e-01 0.008 0 0
Assembly of the pre-replicative complex R-HSA-68867 9.827951e-01 0.008 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.831297e-01 0.007 0 0
Synthesis of PA R-HSA-1483166 9.831325e-01 0.007 0 0
Defective pyroptosis R-HSA-9710421 9.836584e-01 0.007 0 0
Collagen formation R-HSA-1474290 9.840519e-01 0.007 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.840980e-01 0.007 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.844302e-01 0.007 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.844644e-01 0.007 0 0
Regulation of gene expression in beta cells R-HSA-210745 9.844644e-01 0.007 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.844644e-01 0.007 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.844644e-01 0.007 0 0
Glucagon-type ligand receptors R-HSA-420092 9.844644e-01 0.007 0 0
Neuronal System R-HSA-112316 9.846635e-01 0.007 0 0
Gap junction trafficking R-HSA-190828 9.852503e-01 0.006 0 0
Proteasome assembly R-HSA-9907900 9.852503e-01 0.006 0 0
Regulation of beta-cell development R-HSA-186712 9.859866e-01 0.006 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.859866e-01 0.006 0 0
Activation of the pre-replicative complex R-HSA-68962 9.862091e-01 0.006 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.862091e-01 0.006 0 0
Neurotransmitter clearance R-HSA-112311 9.862091e-01 0.006 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.866908e-01 0.006 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.866908e-01 0.006 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.866908e-01 0.006 0 0
Synthesis of DNA R-HSA-69239 9.872166e-01 0.006 0 0
GABA receptor activation R-HSA-977443 9.872338e-01 0.006 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.877579e-01 0.005 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.877579e-01 0.005 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.877579e-01 0.005 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.879939e-01 0.005 0 0
Protein ubiquitination R-HSA-8852135 9.887425e-01 0.005 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.887425e-01 0.005 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.887457e-01 0.005 0 0
Neutrophil degranulation R-HSA-6798695 9.890347e-01 0.005 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.891329e-01 0.005 0 0
DAG1 glycosylations R-HSA-8931838 9.891329e-01 0.005 0 0
HS-GAG degradation R-HSA-2024096 9.891329e-01 0.005 0 0
Regulation of insulin secretion R-HSA-422356 9.891450e-01 0.005 0 0
Mitochondrial protein import R-HSA-1268020 9.894157e-01 0.005 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.902376e-01 0.004 0 0
Gap junction trafficking and regulation R-HSA-157858 9.912002e-01 0.004 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.912002e-01 0.004 0 0
Protein localization R-HSA-9609507 9.912013e-01 0.004 0 0
Base Excision Repair R-HSA-73884 9.912100e-01 0.004 0 0
ABC transporter disorders R-HSA-5619084 9.913435e-01 0.004 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 9.914370e-01 0.004 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.914370e-01 0.004 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.914370e-01 0.004 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.914370e-01 0.004 0 0
Transmission across Chemical Synapses R-HSA-112315 9.914428e-01 0.004 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.919105e-01 0.004 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.923989e-01 0.003 0 0
Dual Incision in GG-NER R-HSA-5696400 9.923989e-01 0.003 0 0
Gap junction assembly R-HSA-190861 9.923989e-01 0.003 0 0
PKR-mediated signaling R-HSA-9833482 9.927462e-01 0.003 0 0
Neddylation R-HSA-8951664 9.928464e-01 0.003 0 0
The phototransduction cascade R-HSA-2514856 9.928552e-01 0.003 0 0
Protein folding R-HSA-391251 9.931551e-01 0.003 0 0
PERK regulates gene expression R-HSA-381042 9.932528e-01 0.003 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.932528e-01 0.003 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.932528e-01 0.003 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.932528e-01 0.003 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.934950e-01 0.003 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.935642e-01 0.003 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.939749e-01 0.003 0 0
HS-GAG biosynthesis R-HSA-2022928 9.940109e-01 0.003 0 0
Triglyceride catabolism R-HSA-163560 9.940109e-01 0.003 0 0
Glycosphingolipid transport R-HSA-9845576 9.940109e-01 0.003 0 0
HSF1 activation R-HSA-3371511 9.940109e-01 0.003 0 0
Interferon gamma signaling R-HSA-877300 9.940864e-01 0.003 0 0
Platelet degranulation R-HSA-114608 9.942977e-01 0.002 0 0
Voltage gated Potassium channels R-HSA-1296072 9.946838e-01 0.002 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.946838e-01 0.002 0 0
NCAM1 interactions R-HSA-419037 9.946838e-01 0.002 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.946838e-01 0.002 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.946838e-01 0.002 0 0
Gene Silencing by RNA R-HSA-211000 9.950956e-01 0.002 0 0
HCMV Infection R-HSA-9609646 9.952773e-01 0.002 0 0
G alpha (z) signalling events R-HSA-418597 9.953025e-01 0.002 0 0
HCMV Early Events R-HSA-9609690 9.953602e-01 0.002 0 0
Leishmania phagocytosis R-HSA-9664417 9.953909e-01 0.002 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.953909e-01 0.002 0 0
Parasite infection R-HSA-9664407 9.953909e-01 0.002 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.954779e-01 0.002 0 0
ECM proteoglycans R-HSA-3000178 9.955145e-01 0.002 0 0
Metabolism of cofactors R-HSA-8978934 9.955145e-01 0.002 0 0
Retinoid metabolism and transport R-HSA-975634 9.955145e-01 0.002 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.956025e-01 0.002 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.957132e-01 0.002 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.957723e-01 0.002 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.958114e-01 0.002 0 0
RAS processing R-HSA-9648002 9.958114e-01 0.002 0 0
DNA Replication Pre-Initiation R-HSA-69002 9.958316e-01 0.002 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.958642e-01 0.002 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 9.959283e-01 0.002 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.962820e-01 0.002 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.962820e-01 0.002 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.963625e-01 0.002 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.966284e-01 0.001 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.968007e-01 0.001 0 0
Peroxisomal protein import R-HSA-9033241 9.969216e-01 0.001 0 0
Triglyceride metabolism R-HSA-8979227 9.969216e-01 0.001 0 0
Viral Infection Pathways R-HSA-9824446 9.969908e-01 0.001 0 0
HCMV Late Events R-HSA-9610379 9.970017e-01 0.001 0 0
RAB geranylgeranylation R-HSA-8873719 9.972316e-01 0.001 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.972316e-01 0.001 0 0
Metabolism of polyamines R-HSA-351202 9.972316e-01 0.001 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.974000e-01 0.001 0 0
Aquaporin-mediated transport R-HSA-445717 9.975108e-01 0.001 0 0
Nucleotide salvage R-HSA-8956321 9.975108e-01 0.001 0 0
Phospholipid metabolism R-HSA-1483257 9.976600e-01 0.001 0 0
Defensins R-HSA-1461973 9.976922e-01 0.001 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.976922e-01 0.001 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.977024e-01 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 9.977336e-01 0.001 0 0
Cholesterol biosynthesis R-HSA-191273 9.977336e-01 0.001 0 0
Developmental Cell Lineages R-HSA-9734767 9.977844e-01 0.001 0 0
Interferon alpha/beta signaling R-HSA-909733 9.978489e-01 0.001 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.979516e-01 0.001 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.979516e-01 0.001 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.981819e-01 0.001 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.981819e-01 0.001 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.982401e-01 0.001 0 0
Platelet homeostasis R-HSA-418346 9.982760e-01 0.001 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.983144e-01 0.001 0 0
DNA Replication R-HSA-69306 9.983686e-01 0.001 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.985407e-01 0.001 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.985677e-01 0.001 0 0
Synthesis of PC R-HSA-1483191 9.985677e-01 0.001 0 0
Nicotinate metabolism R-HSA-196807 9.986892e-01 0.001 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.987220e-01 0.001 0 0
Potassium Channels R-HSA-1296071 9.987220e-01 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 9.988227e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.988717e-01 0.000 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.988717e-01 0.000 0 0
Signaling by NOTCH R-HSA-157118 9.988791e-01 0.000 0 0
Interferon Signaling R-HSA-913531 9.988851e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.989979e-01 0.000 0 0
COPII-mediated vesicle transport R-HSA-204005 9.990508e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.990508e-01 0.000 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.990763e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.991112e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.991112e-01 0.000 0 0
ABC-family proteins mediated transport R-HSA-382556 9.991233e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.993755e-01 0.000 0 0
Neurotransmitter release cycle R-HSA-112310 9.993800e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.994473e-01 0.000 0 0
SLC transporter disorders R-HSA-5619102 9.994491e-01 0.000 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.995105e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.995656e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.996266e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.996422e-01 0.000 0 0
Parasitic Infection Pathways R-HSA-9824443 9.996511e-01 0.000 0 0
Leishmania infection R-HSA-9658195 9.996511e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.996578e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.996578e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.996578e-01 0.000 0 0
tRNA Aminoacylation R-HSA-379724 9.996963e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.997481e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.997536e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.997730e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.997780e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.997877e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.998328e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.998509e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.998683e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.998683e-01 0.000 0 0
Hemostasis R-HSA-109582 9.998874e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999040e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999080e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.999183e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999357e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999409e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.999429e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999475e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999494e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.999494e-01 0.000 0 0
tRNA processing R-HSA-72306 9.999611e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999646e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999720e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999751e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999753e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999773e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999783e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999827e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999854e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999863e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999879e-01 0.000 0 0
Translation R-HSA-72766 9.999911e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999921e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999931e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999959e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999971e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999977e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999979e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999980e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999983e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999988e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999989e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999990e-01 0.000 0 0
Immune System R-HSA-168256 9.999993e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999994e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999995e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999995e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999995e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999995e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999995e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999996e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999997e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999998e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999998e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999999e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999999e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999999e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999999e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 1.000000e+00 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Eukaryotic Translation Initiation R-HSA-72613 1.110223e-16 15.955 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.110223e-16 15.955 0 0
M Phase R-HSA-68886 1.110223e-16 15.955 0 0
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 0 0
Cell Cycle, Mitotic R-HSA-69278 1.110223e-16 15.955 0 0
Metabolism of RNA R-HSA-8953854 1.110223e-16 15.955 0 0
Cellular responses to stress R-HSA-2262752 1.110223e-16 15.955 0 0
Cellular responses to stimuli R-HSA-8953897 1.110223e-16 15.955 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 3.330669e-16 15.477 0 0
Mitotic Prometaphase R-HSA-68877 6.661338e-16 15.176 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.221245e-15 14.913 0 0
Axon guidance R-HSA-422475 2.442491e-15 14.612 0 0
Formation of a pool of free 40S subunits R-HSA-72689 4.662937e-15 14.331 0 0
Eukaryotic Translation Elongation R-HSA-156842 5.440093e-15 14.264 0 0
Nervous system development R-HSA-9675108 8.326673e-15 14.080 0 0
Cell Cycle Checkpoints R-HSA-69620 4.396483e-14 13.357 0 0
Peptide chain elongation R-HSA-156902 3.714806e-13 12.430 0 0
Signaling by ROBO receptors R-HSA-376176 4.829470e-13 12.316 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 5.563328e-13 12.255 0 0
Cell-Cell communication R-HSA-1500931 5.787593e-13 12.238 0 0
Mitotic Prophase R-HSA-68875 9.692247e-13 12.014 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.035505e-12 11.985 0 0
Influenza Infection R-HSA-168255 1.060818e-12 11.974 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.270428e-12 11.896 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.247780e-12 11.904 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.780354e-12 11.749 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.730949e-12 11.762 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.164269e-12 11.665 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 3.331446e-12 11.477 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 5.555112e-12 11.255 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 5.873413e-12 11.231 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 6.110890e-12 11.214 0 0
Mitotic Anaphase R-HSA-68882 6.235346e-12 11.205 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 7.418732e-12 11.130 0 0
Separation of Sister Chromatids R-HSA-2467813 1.119815e-11 10.951 0 0
Ribosome-associated quality control R-HSA-9948299 1.186407e-11 10.926 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.270473e-11 10.896 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.259637e-11 10.900 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.259637e-11 10.900 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.492340e-11 10.826 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.478850e-11 10.830 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.967537e-11 10.528 0 0
Viral Infection Pathways R-HSA-9824446 3.020983e-11 10.520 0 0
DNA methylation R-HSA-5334118 3.669931e-11 10.435 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 4.581735e-11 10.339 0 0
HDACs deacetylate histones R-HSA-3214815 5.051426e-11 10.297 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 5.907164e-11 10.229 0 0
Eukaryotic Translation Termination R-HSA-72764 7.653100e-11 10.116 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 8.127310e-11 10.090 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 8.619427e-11 10.065 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.147994e-10 9.940 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.248185e-10 9.904 0 0
Cell junction organization R-HSA-446728 1.293164e-10 9.888 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.459021e-10 9.836 0 0
HCMV Early Events R-HSA-9609690 2.011699e-10 9.696 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.291354e-10 9.640 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.861330e-10 9.543 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.472405e-10 9.459 0 0
Selenocysteine synthesis R-HSA-2408557 3.474772e-10 9.459 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 3.776457e-10 9.423 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 4.385459e-10 9.358 0 0
Viral mRNA Translation R-HSA-192823 5.612895e-10 9.251 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 5.472589e-10 9.262 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 6.094588e-10 9.215 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 6.094588e-10 9.215 0 0
Signal Transduction R-HSA-162582 7.299454e-10 9.137 0 0
G2/M Checkpoints R-HSA-69481 7.511400e-10 9.124 0 0
RNA Polymerase I Transcription R-HSA-73864 9.626862e-10 9.017 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.082590e-09 8.966 0 0
Meiotic recombination R-HSA-912446 1.200071e-09 8.921 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.227624e-09 8.911 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.414721e-09 8.849 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.584742e-09 8.800 0 0
Meiosis R-HSA-1500620 1.678468e-09 8.775 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.003256e-09 8.698 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 2.109436e-09 8.676 0 0
Meiotic synapsis R-HSA-1221632 2.357367e-09 8.628 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 2.388961e-09 8.622 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.751689e-09 8.560 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.718467e-09 8.566 0 0
Nucleosome assembly R-HSA-774815 3.063654e-09 8.514 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.063654e-09 8.514 0 0
Packaging Of Telomere Ends R-HSA-171306 3.145259e-09 8.502 0 0
Translation initiation complex formation R-HSA-72649 3.269211e-09 8.486 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.583737e-09 8.339 0 0
Diseases of programmed cell death R-HSA-9645723 4.583737e-09 8.339 0 0
G2/M DNA damage checkpoint R-HSA-69473 4.613252e-09 8.336 0 0
Assembly of the pre-replicative complex R-HSA-68867 5.599016e-09 8.252 0 0
Gene Silencing by RNA R-HSA-211000 5.708640e-09 8.243 0 0
Recycling pathway of L1 R-HSA-437239 6.156520e-09 8.211 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 6.162713e-09 8.210 0 0
Chromatin organization R-HSA-4839726 6.377704e-09 8.195 0 0
Adherens junctions interactions R-HSA-418990 7.116792e-09 8.148 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 7.660312e-09 8.116 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 7.355150e-09 8.133 0 0
Aggrephagy R-HSA-9646399 7.660312e-09 8.116 0 0
Cell-cell junction organization R-HSA-421270 8.317681e-09 8.080 0 0
rRNA processing R-HSA-72312 8.588237e-09 8.066 0 0
DNA Replication Pre-Initiation R-HSA-69002 8.721932e-09 8.059 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.185025e-09 8.037 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 9.452007e-09 8.024 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.106706e-08 7.956 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.106706e-08 7.956 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.113296e-08 7.953 0 0
G2/M Transition R-HSA-69275 1.343673e-08 7.872 0 0
mRNA Splicing R-HSA-72172 1.421827e-08 7.847 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.816815e-08 7.741 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.825022e-08 7.739 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.948075e-08 7.710 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.606083e-08 7.584 0 0
Chromatin modifying enzymes R-HSA-3247509 2.661052e-08 7.575 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 2.857661e-08 7.544 0 0
Defective pyroptosis R-HSA-9710421 3.156577e-08 7.501 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 3.493450e-08 7.457 0 0
HCMV Infection R-HSA-9609646 3.902103e-08 7.409 0 0
Cellular response to starvation R-HSA-9711097 4.381936e-08 7.358 0 0
Regulation of endogenous retroelements R-HSA-9842860 4.992641e-08 7.302 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 4.992641e-08 7.302 0 0
Ub-specific processing proteases R-HSA-5689880 7.785497e-08 7.109 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 7.971836e-08 7.098 0 0
Cellular Senescence R-HSA-2559583 8.714216e-08 7.060 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 8.343797e-08 7.079 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.113630e-08 7.040 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.753717e-08 7.011 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.334484e-07 6.875 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.673023e-07 6.776 0 0
Selective autophagy R-HSA-9663891 1.688453e-07 6.773 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.834275e-07 6.737 0 0
Apoptosis R-HSA-109581 2.073142e-07 6.683 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.465042e-07 6.608 0 0
HATs acetylate histones R-HSA-3214847 2.524401e-07 6.598 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.578418e-07 6.589 0 0
Cleavage of the damaged purine R-HSA-110331 2.625319e-07 6.581 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.631251e-07 6.580 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.767742e-07 6.558 0 0
Interleukin-12 signaling R-HSA-9020591 3.304250e-07 6.481 0 0
Chromosome Maintenance R-HSA-73886 3.604678e-07 6.443 0 0
Cellular response to heat stress R-HSA-3371556 3.604678e-07 6.443 0 0
Depurination R-HSA-73927 3.660759e-07 6.436 0 0
L1CAM interactions R-HSA-373760 4.197297e-07 6.377 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 5.232143e-07 6.281 0 0
SARS-CoV-1 Infection R-HSA-9678108 6.164441e-07 6.210 0 0
Selenoamino acid metabolism R-HSA-2408522 6.809088e-07 6.167 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 6.951081e-07 6.158 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 8.066662e-07 6.093 0 0
Reproduction R-HSA-1474165 8.184110e-07 6.087 0 0
DNA Replication R-HSA-69306 8.543147e-07 6.068 0 0
Amyloid fiber formation R-HSA-977225 9.762468e-07 6.010 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.129203e-06 5.947 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.199771e-06 5.921 0 0
Co-inhibition by PD-1 R-HSA-389948 1.251850e-06 5.902 0 0
Post NMDA receptor activation events R-HSA-438064 1.310962e-06 5.882 0 0
Apoptotic execution phase R-HSA-75153 1.339643e-06 5.873 0 0
Telomere Maintenance R-HSA-157579 1.476766e-06 5.831 0 0
Developmental Biology R-HSA-1266738 1.550955e-06 5.809 0 0
DNA Double Strand Break Response R-HSA-5693606 1.562941e-06 5.806 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.690109e-06 5.772 0 0
Depyrimidination R-HSA-73928 1.690109e-06 5.772 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.733694e-06 5.761 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.874066e-06 5.727 0 0
Translation R-HSA-72766 2.029048e-06 5.693 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.093242e-06 5.679 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.093242e-06 5.679 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.294872e-06 5.639 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.569966e-06 5.590 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.649487e-06 5.577 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.649487e-06 5.577 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.992068e-06 5.524 0 0
Autophagy R-HSA-9612973 3.118081e-06 5.506 0 0
Kinesins R-HSA-983189 3.519815e-06 5.453 0 0
Interleukin-12 family signaling R-HSA-447115 3.865081e-06 5.413 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.967825e-06 5.401 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 3.981012e-06 5.400 0 0
AURKA Activation by TPX2 R-HSA-8854518 4.078388e-06 5.390 0 0
Macroautophagy R-HSA-1632852 4.799326e-06 5.319 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 4.943876e-06 5.306 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 5.601987e-06 5.252 0 0
Cytokine Signaling in Immune system R-HSA-1280215 5.944181e-06 5.226 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 6.229363e-06 5.206 0 0
SARS-CoV-2 Infection R-HSA-9694516 7.001805e-06 5.155 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 8.291903e-06 5.081 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 8.291903e-06 5.081 0 0
SARS-CoV Infections R-HSA-9679506 8.400305e-06 5.076 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.088294e-05 4.963 0 0
Homology Directed Repair R-HSA-5693538 1.047219e-05 4.980 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.138774e-05 4.944 0 0
Programmed Cell Death R-HSA-5357801 1.179529e-05 4.928 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.386984e-05 4.858 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.449904e-05 4.839 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.456935e-05 4.837 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.584211e-05 4.800 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.648390e-05 4.783 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.678811e-05 4.775 0 0
tRNA processing in the nucleus R-HSA-6784531 1.750480e-05 4.757 0 0
Base Excision Repair R-HSA-73884 1.840000e-05 4.735 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.132895e-05 4.671 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.166805e-05 4.664 0 0
Centrosome maturation R-HSA-380287 2.434251e-05 4.614 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.454352e-05 4.610 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.486337e-05 4.604 0 0
Deubiquitination R-HSA-5688426 2.594466e-05 4.586 0 0
Chaperone Mediated Autophagy R-HSA-9613829 3.361820e-05 4.473 0 0
Chaperonin-mediated protein folding R-HSA-390466 3.016969e-05 4.520 0 0
Nuclear import of Rev protein R-HSA-180746 3.081453e-05 4.511 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 3.252350e-05 4.488 0 0
Interferon Signaling R-HSA-913531 3.440369e-05 4.463 0 0
ESR-mediated signaling R-HSA-8939211 3.580167e-05 4.446 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.975791e-05 4.401 0 0
HCMV Late Events R-HSA-9610379 4.117350e-05 4.385 0 0
Mitotic Spindle Checkpoint R-HSA-69618 4.667162e-05 4.331 0 0
Signaling by NOTCH R-HSA-157118 4.734989e-05 4.325 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 5.191032e-05 4.285 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 5.589133e-05 4.253 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 5.727380e-05 4.242 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 6.249817e-05 4.204 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 6.808329e-05 4.167 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 6.808329e-05 4.167 0 0
Protein folding R-HSA-391251 7.773314e-05 4.109 0 0
Membrane Trafficking R-HSA-199991 7.876628e-05 4.104 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 8.027212e-05 4.095 0 0
Cilium Assembly R-HSA-5617833 8.264857e-05 4.083 0 0
Signaling by WNT R-HSA-195721 8.453080e-05 4.073 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 8.588900e-05 4.066 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 8.848157e-05 4.053 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.151456e-04 3.939 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.026568e-04 3.989 0 0
Glycolysis R-HSA-70171 1.152640e-04 3.938 0 0
Gap junction trafficking and regulation R-HSA-157858 1.135107e-04 3.945 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.182122e-04 3.927 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.255555e-04 3.901 0 0
RMTs methylate histone arginines R-HSA-3214858 1.258384e-04 3.900 0 0
Gap junction trafficking R-HSA-190828 1.258384e-04 3.900 0 0
Signaling by Interleukins R-HSA-449147 1.309630e-04 3.883 0 0
Metalloprotease DUBs R-HSA-5689901 1.477014e-04 3.831 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.499832e-04 3.824 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.499832e-04 3.824 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.522360e-04 3.817 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.601409e-04 3.795 0 0
Infectious disease R-HSA-5663205 1.620682e-04 3.790 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.622315e-04 3.790 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.628943e-04 3.788 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.635132e-04 3.786 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.911457e-04 3.719 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.911457e-04 3.719 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.911457e-04 3.719 0 0
Signaling by RAS mutants R-HSA-6802949 1.911457e-04 3.719 0 0
mRNA 3'-end processing R-HSA-72187 2.052682e-04 3.688 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.127158e-04 3.672 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.157909e-04 3.666 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.323304e-04 3.634 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.323304e-04 3.634 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.474885e-04 3.606 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 2.564902e-04 3.591 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.582103e-04 3.588 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.625690e-04 3.581 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.975536e-04 3.526 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 3.003426e-04 3.522 0 0
Nephrin family interactions R-HSA-373753 3.117894e-04 3.506 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 3.558804e-04 3.449 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.138232e-04 3.503 0 0
HIV Life Cycle R-HSA-162587 3.771809e-04 3.423 0 0
PKR-mediated signaling R-HSA-9833482 3.928441e-04 3.406 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.930837e-04 3.406 0 0
Gap junction assembly R-HSA-190861 3.947427e-04 3.404 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 4.287417e-04 3.368 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.423913e-04 3.354 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 4.423913e-04 3.354 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 4.438384e-04 3.353 0 0
Signaling by PTK6 R-HSA-8848021 4.998997e-04 3.301 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.998997e-04 3.301 0 0
Regulation of CDH1 Function R-HSA-9764561 5.027130e-04 3.299 0 0
Activation of HOX genes during differentiation R-HSA-5619507 5.150354e-04 3.288 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 5.150354e-04 3.288 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 5.914530e-04 3.228 0 0
Glucose metabolism R-HSA-70326 6.132457e-04 3.212 0 0
Regulation of PTEN localization R-HSA-8948747 6.447110e-04 3.191 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 6.447110e-04 3.191 0 0
MAP2K and MAPK activation R-HSA-5674135 6.618979e-04 3.179 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 6.720115e-04 3.173 0 0
snRNP Assembly R-HSA-191859 6.989195e-04 3.156 0 0
Metabolism of non-coding RNA R-HSA-194441 6.989195e-04 3.156 0 0
Organelle biogenesis and maintenance R-HSA-1852241 7.215278e-04 3.142 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 8.382973e-04 3.077 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 8.433220e-04 3.074 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 8.561417e-04 3.067 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 8.754155e-04 3.058 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 8.754155e-04 3.058 0 0
p75NTR signals via NF-kB R-HSA-193639 8.754155e-04 3.058 0 0
Cell-extracellular matrix interactions R-HSA-446353 8.754155e-04 3.058 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 8.754155e-04 3.058 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 9.572792e-04 3.019 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.012739e-03 2.995 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.048950e-03 2.979 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.048950e-03 2.979 0 0
Death Receptor Signaling R-HSA-73887 1.100828e-03 2.958 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.267064e-03 2.897 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.575438e-03 2.803 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.575438e-03 2.803 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.459236e-03 2.836 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.575438e-03 2.803 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.429768e-03 2.845 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.374956e-03 2.862 0 0
UCH proteinases R-HSA-5689603 1.331451e-03 2.876 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.376015e-03 2.861 0 0
Hedgehog 'off' state R-HSA-5610787 1.391111e-03 2.857 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.576962e-03 2.802 0 0
Signaling by ALK in cancer R-HSA-9700206 1.576962e-03 2.802 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.613094e-03 2.792 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.616718e-03 2.791 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.616718e-03 2.791 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 1.624051e-03 2.789 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.631262e-03 2.787 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.882420e-03 2.725 0 0
DNA Repair R-HSA-73894 1.938917e-03 2.712 0 0
Signaling by ERBB2 R-HSA-1227986 2.093422e-03 2.679 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.094548e-03 2.679 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 2.119825e-03 2.674 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.153803e-03 2.667 0 0
MyD88-independent TLR4 cascade R-HSA-166166 2.162599e-03 2.665 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 2.162599e-03 2.665 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.265863e-03 2.645 0 0
MHC class II antigen presentation R-HSA-2132295 2.349591e-03 2.629 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.411940e-03 2.618 0 0
Folding of actin by CCT/TriC R-HSA-390450 2.411940e-03 2.618 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.411940e-03 2.618 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.510738e-03 2.600 0 0
Host Interactions of HIV factors R-HSA-162909 2.583722e-03 2.588 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.643550e-03 2.578 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.655737e-03 2.576 0 0
mTORC1-mediated signalling R-HSA-166208 2.691949e-03 2.570 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 2.800589e-03 2.553 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 3.169304e-03 2.499 0 0
Striated Muscle Contraction R-HSA-390522 3.180158e-03 2.498 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.181236e-03 2.497 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.224169e-03 2.492 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.379844e-03 2.471 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 3.457412e-03 2.461 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 3.457412e-03 2.461 0 0
HIV Infection R-HSA-162906 3.482324e-03 2.458 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 3.557062e-03 2.449 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 3.557062e-03 2.449 0 0
Regulation of signaling by CBL R-HSA-912631 3.662888e-03 2.436 0 0
Translesion Synthesis by POLH R-HSA-110320 3.662888e-03 2.436 0 0
Rap1 signalling R-HSA-392517 3.662888e-03 2.436 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 3.673043e-03 2.435 0 0
Late endosomal microautophagy R-HSA-9615710 3.686455e-03 2.433 0 0
DCC mediated attractive signaling R-HSA-418885 3.751880e-03 2.426 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 3.751880e-03 2.426 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 3.751880e-03 2.426 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 3.751880e-03 2.426 0 0
Cellular response to chemical stress R-HSA-9711123 3.876807e-03 2.412 0 0
NF-kB is activated and signals survival R-HSA-209560 4.807183e-03 2.318 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 4.807183e-03 2.318 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 4.930444e-03 2.307 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 4.198833e-03 2.377 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.992019e-03 2.399 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 4.807183e-03 2.318 0 0
COPI-mediated anterograde transport R-HSA-6807878 4.034236e-03 2.394 0 0
Smooth Muscle Contraction R-HSA-445355 4.744868e-03 2.324 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 5.025304e-03 2.299 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 5.025304e-03 2.299 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 5.164978e-03 2.287 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 5.164978e-03 2.287 0 0
Negative regulation of MAPK pathway R-HSA-5675221 5.250991e-03 2.280 0 0
HSF1 activation R-HSA-3371511 5.385941e-03 2.269 0 0
Regulation of TP53 Degradation R-HSA-6804757 5.385941e-03 2.269 0 0
FLT3 signaling in disease R-HSA-9682385 5.385941e-03 2.269 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 5.808217e-03 2.236 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 5.838709e-03 2.234 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 5.838709e-03 2.234 0 0
Signaling by VEGF R-HSA-194138 5.935771e-03 2.227 0 0
Protein ubiquitination R-HSA-8852135 6.076718e-03 2.216 0 0
Regulation of TP53 Activity R-HSA-5633007 6.144915e-03 2.211 0 0
Ovarian tumor domain proteases R-HSA-5689896 6.342785e-03 2.198 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.367738e-03 2.196 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 6.367738e-03 2.196 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 6.508910e-03 2.186 0 0
IRAK1 recruits IKK complex R-HSA-937039 6.508910e-03 2.186 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 6.508910e-03 2.186 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 6.672051e-03 2.176 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 6.672051e-03 2.176 0 0
TNF signaling R-HSA-75893 7.074770e-03 2.150 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.239881e-03 2.140 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.521297e-03 2.124 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 7.605954e-03 2.119 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 7.605954e-03 2.119 0 0
S Phase R-HSA-69242 7.825221e-03 2.107 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 8.027397e-03 2.095 0 0
Signaling by Hippo R-HSA-2028269 8.095726e-03 2.092 0 0
Signaling by Nuclear Receptors R-HSA-9006931 8.123484e-03 2.090 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 8.267746e-03 2.083 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 8.267746e-03 2.083 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 9.595926e-03 2.018 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 8.610206e-03 2.065 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.115770e-02 1.952 0 0
Orc1 removal from chromatin R-HSA-68949 9.914789e-03 2.004 0 0
EPH-Ephrin signaling R-HSA-2682334 1.005061e-02 1.998 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.115472e-03 2.040 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.115770e-02 1.952 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.136856e-02 1.944 0 0
Mitophagy R-HSA-5205647 1.054022e-02 1.977 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 9.809346e-03 2.008 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 9.809346e-03 2.008 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 9.809346e-03 2.008 0 0
Josephin domain DUBs R-HSA-5689877 1.136856e-02 1.944 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.115770e-02 1.952 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 8.948242e-03 2.048 0 0
NOD1/2 Signaling Pathway R-HSA-168638 1.054022e-02 1.977 0 0
Intracellular signaling by second messengers R-HSA-9006925 9.786467e-03 2.009 0 0
G1/S Transition R-HSA-69206 1.092311e-02 1.962 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.044103e-02 1.981 0 0
Pexophagy R-HSA-9664873 1.136856e-02 1.944 0 0
Muscle contraction R-HSA-397014 9.943654e-03 2.002 0 0
Maturation of protein E R-HSA-9683683 9.595926e-03 2.018 0 0
Maturation of protein E R-HSA-9694493 9.595926e-03 2.018 0 0
Signaling by NOTCH4 R-HSA-9013694 1.159788e-02 1.936 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.183206e-02 1.927 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.187717e-02 1.925 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.255141e-02 1.901 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.269733e-02 1.896 0 0
Activation of BH3-only proteins R-HSA-114452 1.280098e-02 1.893 0 0
MAP kinase activation R-HSA-450294 1.289431e-02 1.890 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.289431e-02 1.890 0 0
Neurodegenerative Diseases R-HSA-8863678 1.297326e-02 1.887 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.297326e-02 1.887 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.334576e-02 1.875 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 1.341749e-02 1.872 0 0
Intraflagellar transport R-HSA-5620924 1.391599e-02 1.856 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.419613e-02 1.848 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.419613e-02 1.848 0 0
Translesion synthesis by REV1 R-HSA-110312 1.419613e-02 1.848 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.419613e-02 1.848 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 1.420753e-02 1.847 0 0
Signaling by NOTCH1 R-HSA-1980143 1.421228e-02 1.847 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 1.456173e-02 1.837 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 1.501236e-02 1.824 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.517267e-02 1.819 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.517907e-02 1.819 0 0
Signal transduction by L1 R-HSA-445144 1.534145e-02 1.814 0 0
Long-term potentiation R-HSA-9620244 1.547116e-02 1.810 0 0
Gene expression (Transcription) R-HSA-74160 1.578114e-02 1.802 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.593400e-02 1.798 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.601136e-02 1.796 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.714374e-02 1.766 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.726366e-02 1.763 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.726533e-02 1.763 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.749274e-02 1.757 0 0
Translesion synthesis by POLI R-HSA-5656121 1.776756e-02 1.750 0 0
Negative regulation of FLT3 R-HSA-9706369 1.776756e-02 1.750 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 1.784764e-02 1.748 0 0
Signaling by TGFB family members R-HSA-9006936 1.794414e-02 1.746 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.808209e-02 1.743 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.808209e-02 1.743 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.808209e-02 1.743 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.808209e-02 1.743 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.808209e-02 1.743 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.808209e-02 1.743 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.829983e-02 1.738 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.854598e-02 1.732 0 0
Signaling by Hedgehog R-HSA-5358351 1.864861e-02 1.729 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.976003e-02 1.704 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.991913e-02 1.701 0 0
HSF1-dependent transactivation R-HSA-3371571 1.991913e-02 1.701 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 1.992886e-02 1.701 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.025904e-02 1.693 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 2.110612e-02 1.676 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 2.145620e-02 1.668 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.191066e-02 1.659 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.191066e-02 1.659 0 0
Translesion synthesis by POLK R-HSA-5655862 2.191066e-02 1.659 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.191066e-02 1.659 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 2.191066e-02 1.659 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 2.208537e-02 1.656 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 2.208537e-02 1.656 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.219276e-02 1.654 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 2.229524e-02 1.652 0 0
Platelet degranulation R-HSA-114608 2.230962e-02 1.652 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.291969e-02 1.640 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.332759e-02 1.632 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.332759e-02 1.632 0 0
Vesicle-mediated transport R-HSA-5653656 2.358217e-02 1.627 0 0
Interleukin-1 signaling R-HSA-9020702 2.370787e-02 1.625 0 0
Dopamine receptors R-HSA-390651 2.412094e-02 1.618 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 2.412094e-02 1.618 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.460999e-02 1.609 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.460999e-02 1.609 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.460999e-02 1.609 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.460999e-02 1.609 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.460999e-02 1.609 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.460999e-02 1.609 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.483471e-02 1.605 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.516340e-02 1.599 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.571694e-02 1.590 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 2.630752e-02 1.580 0 0
Developmental Cell Lineages R-HSA-9734767 2.641203e-02 1.578 0 0
RAF activation R-HSA-5673000 2.671402e-02 1.573 0 0
Dual Incision in GG-NER R-HSA-5696400 2.671402e-02 1.573 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 2.671402e-02 1.573 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 2.671402e-02 1.573 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 2.711291e-02 1.567 0 0
Modulation by Mtb of host immune system R-HSA-9637628 2.711291e-02 1.567 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.740506e-02 1.562 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 2.756448e-02 1.560 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.760631e-02 1.559 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.807553e-02 1.419 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 3.558809e-02 1.449 0 0
Regulation of KIT signaling R-HSA-1433559 3.859679e-02 1.413 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 3.859679e-02 1.413 0 0
Ephrin signaling R-HSA-3928664 3.204591e-02 1.494 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.332972e-02 1.477 0 0
Activation of the pre-replicative complex R-HSA-68962 3.332972e-02 1.477 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.332972e-02 1.477 0 0
EGFR downregulation R-HSA-182971 3.810617e-02 1.419 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 3.810617e-02 1.419 0 0
Neutrophil degranulation R-HSA-6798695 3.405202e-02 1.468 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.755671e-02 1.425 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 3.053610e-02 1.515 0 0
DNA Damage Bypass R-HSA-73893 3.456432e-02 1.461 0 0
G alpha (12/13) signalling events R-HSA-416482 3.347000e-02 1.475 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 3.192235e-02 1.496 0 0
Cellular response to hypoxia R-HSA-1234174 3.964136e-02 1.402 0 0
Switching of origins to a post-replicative state R-HSA-69052 4.140159e-02 1.383 0 0
Circadian clock R-HSA-9909396 3.320327e-02 1.479 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 3.104300e-02 1.508 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 3.104300e-02 1.508 0 0
MTOR signalling R-HSA-165159 3.481973e-02 1.458 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 3.204591e-02 1.494 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 3.043303e-02 1.517 0 0
Degradation of DVL R-HSA-4641258 3.892258e-02 1.410 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.807553e-02 1.419 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.481973e-02 1.458 0 0
Platelet activation, signaling and aggregation R-HSA-76002 4.302219e-02 1.366 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.977266e-02 1.526 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.391708e-02 1.470 0 0
NRIF signals cell death from the nucleus R-HSA-205043 3.859679e-02 1.413 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.192235e-02 1.496 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.552281e-02 1.449 0 0
Immune System R-HSA-168256 3.811978e-02 1.419 0 0
MAPK family signaling cascades R-HSA-5683057 3.640805e-02 1.439 0 0
Interleukin-17 signaling R-HSA-448424 3.192235e-02 1.496 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.391708e-02 1.470 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 3.769715e-02 1.424 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 3.558809e-02 1.449 0 0
Semaphorin interactions R-HSA-373755 3.300634e-02 1.481 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.755671e-02 1.425 0 0
IRE1alpha activates chaperones R-HSA-381070 3.302714e-02 1.481 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 4.330902e-02 1.363 0 0
G0 and Early G1 R-HSA-1538133 4.332052e-02 1.363 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 4.449713e-02 1.352 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 4.482273e-02 1.349 0 0
Disease R-HSA-1643685 4.626054e-02 1.335 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 4.668113e-02 1.331 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 4.668113e-02 1.331 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 4.787220e-02 1.320 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 4.787220e-02 1.320 0 0
Myogenesis R-HSA-525793 4.787220e-02 1.320 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 4.803991e-02 1.318 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 4.803991e-02 1.318 0 0
Adaptive Immune System R-HSA-1280218 4.837139e-02 1.315 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 4.889176e-02 1.311 0 0
Stabilization of p53 R-HSA-69541 4.889176e-02 1.311 0 0
G-protein beta:gamma signalling R-HSA-397795 4.898464e-02 1.310 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 4.898464e-02 1.310 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 4.937840e-02 1.306 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 4.937840e-02 1.306 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 4.937840e-02 1.306 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 4.937840e-02 1.306 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 5.119119e-02 1.291 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 5.133396e-02 1.290 0 0
Opioid Signalling R-HSA-111885 5.146659e-02 1.288 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 5.224846e-02 1.282 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 5.224846e-02 1.282 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 5.224846e-02 1.282 0 0
PTEN Regulation R-HSA-6807070 5.338440e-02 1.273 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 5.373556e-02 1.270 0 0
PLC beta mediated events R-HSA-112043 5.380856e-02 1.269 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 5.445532e-02 1.264 0 0
Attenuation phase R-HSA-3371568 5.445532e-02 1.264 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 5.445532e-02 1.264 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 5.462088e-02 1.263 0 0
Inositol phosphate metabolism R-HSA-1483249 5.489931e-02 1.260 0 0
Vpu mediated degradation of CD4 R-HSA-180534 5.510828e-02 1.259 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 5.569642e-02 1.254 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 5.639909e-02 1.249 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 5.807586e-02 1.236 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 5.807586e-02 1.236 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 6.022206e-02 1.220 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 6.037990e-02 1.219 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 6.037990e-02 1.219 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 6.037990e-02 1.219 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 6.037990e-02 1.219 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 6.037990e-02 1.219 0 0
Assembly Of The HIV Virion R-HSA-175474 6.037990e-02 1.219 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 6.041481e-02 1.219 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 6.041481e-02 1.219 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 6.041481e-02 1.219 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 6.148049e-02 1.211 0 0
Signaling by NOTCH3 R-HSA-9012852 6.148049e-02 1.211 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 6.169908e-02 1.210 0 0
Signaling by NOTCH2 R-HSA-1980145 6.169908e-02 1.210 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 6.169908e-02 1.210 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 6.206136e-02 1.207 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 6.338635e-02 1.198 0 0
Regulation of TP53 Expression R-HSA-6804754 6.338635e-02 1.198 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 6.338635e-02 1.198 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 6.338635e-02 1.198 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 6.338635e-02 1.198 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 6.338635e-02 1.198 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 6.338635e-02 1.198 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 6.338635e-02 1.198 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 6.338635e-02 1.198 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 6.338635e-02 1.198 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 6.338635e-02 1.198 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 6.338635e-02 1.198 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 6.338635e-02 1.198 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 6.338635e-02 1.198 0 0
Toll-like Receptor Cascades R-HSA-168898 6.512492e-02 1.186 0 0
Potential therapeutics for SARS R-HSA-9679191 6.516607e-02 1.186 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.537929e-02 1.185 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.537929e-02 1.185 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.537929e-02 1.185 0 0
Disorders of Developmental Biology R-HSA-9675151 6.564458e-02 1.183 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 6.564458e-02 1.183 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 6.564458e-02 1.183 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 6.564458e-02 1.183 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 6.600057e-02 1.180 0 0
Synthesis of DNA R-HSA-69239 6.634139e-02 1.178 0 0
Degradation of CRY and PER proteins R-HSA-9932298 6.677578e-02 1.175 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 6.677578e-02 1.175 0 0
Signaling by EGFR R-HSA-177929 6.701364e-02 1.174 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 6.701364e-02 1.174 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 6.701364e-02 1.174 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 6.876241e-02 1.163 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 6.876241e-02 1.163 0 0
Regulation of Apoptosis R-HSA-169911 6.876241e-02 1.163 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 6.883417e-02 1.162 0 0
Activation of RAC1 R-HSA-428540 6.883417e-02 1.162 0 0
Signaling by AMER1 mutants R-HSA-4839748 6.883417e-02 1.162 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 6.883417e-02 1.162 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 6.883417e-02 1.162 0 0
Ion transport by P-type ATPases R-HSA-936837 6.891284e-02 1.162 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 6.908015e-02 1.161 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 6.908015e-02 1.161 0 0
FGFR2 alternative splicing R-HSA-6803529 6.922090e-02 1.160 0 0
Notch-HLH transcription pathway R-HSA-350054 6.922090e-02 1.160 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 6.922090e-02 1.160 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 6.922090e-02 1.160 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.981629e-02 1.156 0 0
Termination of translesion DNA synthesis R-HSA-5656169 6.981629e-02 1.156 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 6.984344e-02 1.156 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 7.015447e-02 1.154 0 0
Degradation of CDH1 R-HSA-9766229 7.037182e-02 1.153 0 0
Ca-dependent events R-HSA-111996 7.354219e-02 1.133 0 0
Calmodulin induced events R-HSA-111933 7.630142e-02 1.117 0 0
CaM pathway R-HSA-111997 7.630142e-02 1.117 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 7.630142e-02 1.117 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 7.651806e-02 1.116 0 0
Dual incision in TC-NER R-HSA-6782135 7.901775e-02 1.102 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 8.071637e-02 1.093 0 0
ER-Phagosome pathway R-HSA-1236974 8.119986e-02 1.090 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 8.255608e-02 1.083 0 0
Disorders of Nervous System Development R-HSA-9697154 8.255608e-02 1.083 0 0
Pervasive developmental disorders R-HSA-9005895 8.255608e-02 1.083 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.255608e-02 1.083 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.255608e-02 1.083 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.255608e-02 1.083 0 0
Unfolded Protein Response (UPR) R-HSA-381119 8.271303e-02 1.082 0 0
TRIF-mediated programmed cell death R-HSA-2562578 8.343542e-02 1.079 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 8.343542e-02 1.079 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 8.343542e-02 1.079 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 8.364754e-02 1.078 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 8.431695e-02 1.074 0 0
Degradation of AXIN R-HSA-4641257 8.431695e-02 1.074 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.431695e-02 1.074 0 0
G-protein mediated events R-HSA-112040 8.653069e-02 1.063 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 8.695800e-02 1.061 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 8.695800e-02 1.061 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.729172e-02 1.059 0 0
Budding and maturation of HIV virion R-HSA-162588 8.729172e-02 1.059 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 8.729172e-02 1.059 0 0
G1 Phase R-HSA-69236 8.829903e-02 1.054 0 0
Cyclin D associated events in G1 R-HSA-69231 8.829903e-02 1.054 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 8.830042e-02 1.054 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 8.830042e-02 1.054 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 8.830042e-02 1.054 0 0
Presynaptic function of Kainate receptors R-HSA-500657 8.830042e-02 1.054 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 8.902048e-02 1.051 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.902048e-02 1.051 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 8.902048e-02 1.051 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.082071e-02 1.042 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.082071e-02 1.042 0 0
MET interacts with TNS proteins R-HSA-8875513 9.280014e-02 1.032 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 9.280014e-02 1.032 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 9.280014e-02 1.032 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 9.280014e-02 1.032 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 9.297132e-02 1.032 0 0
Nucleotide Excision Repair R-HSA-5696398 9.523376e-02 1.021 0 0
DAG and IP3 signaling R-HSA-1489509 9.628926e-02 1.016 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.628926e-02 1.016 0 0
Drug resistance of KIT mutants R-HSA-9669937 9.672058e-02 1.014 0 0
KIT mutants bind TKIs R-HSA-9669921 9.672058e-02 1.014 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 9.672058e-02 1.014 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 9.672058e-02 1.014 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 9.672058e-02 1.014 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 9.672058e-02 1.014 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 9.672058e-02 1.014 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 9.672058e-02 1.014 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 9.672058e-02 1.014 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 9.672058e-02 1.014 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 9.672058e-02 1.014 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 9.672058e-02 1.014 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 9.750979e-02 1.011 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 9.750979e-02 1.011 0 0
Frs2-mediated activation R-HSA-170968 9.750979e-02 1.011 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 9.750979e-02 1.011 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.832975e-02 1.007 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 9.878925e-02 1.005 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 9.969682e-02 1.001 0 0
HDMs demethylate histones R-HSA-3214842 9.996083e-02 1.000 0 0
Sema4D in semaphorin signaling R-HSA-400685 9.996083e-02 1.000 0 0
RNA Polymerase II Transcription R-HSA-73857 1.004197e-01 0.998 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.009670e-01 0.996 0 0
Other interleukin signaling R-HSA-449836 1.009670e-01 0.996 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.840914e-01 0.735 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 1.840914e-01 0.735 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 1.840914e-01 0.735 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.840914e-01 0.735 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 1.840914e-01 0.735 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 1.840914e-01 0.735 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.252874e-01 0.902 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.252874e-01 0.902 0 0
Signaling by MAP2K mutants R-HSA-9652169 1.252874e-01 0.902 0 0
IRS activation R-HSA-74713 1.599794e-01 0.796 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 1.599794e-01 0.796 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.599794e-01 0.796 0 0
Type I hemidesmosome assembly R-HSA-446107 1.033621e-01 0.986 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 1.033621e-01 0.986 0 0
Formation of annular gap junctions R-HSA-196025 1.033621e-01 0.986 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.033621e-01 0.986 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.033621e-01 0.986 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 1.249560e-01 0.903 0 0
Gap junction degradation R-HSA-190873 1.249560e-01 0.903 0 0
Calcineurin activates NFAT R-HSA-2025928 1.249560e-01 0.903 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 1.961462e-01 0.707 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.961462e-01 0.707 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.961462e-01 0.707 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 1.961462e-01 0.707 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 1.961462e-01 0.707 0 0
PI3K/AKT activation R-HSA-198203 1.480041e-01 0.830 0 0
MAPK3 (ERK1) activation R-HSA-110056 1.480041e-01 0.830 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 1.136270e-01 0.945 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.722905e-01 0.764 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.722905e-01 0.764 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.722905e-01 0.764 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.308286e-01 0.883 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.308286e-01 0.883 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.308286e-01 0.883 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.144859e-01 0.941 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.490272e-01 0.827 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 1.490272e-01 0.827 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.976015e-01 0.704 0 0
Basigin interactions R-HSA-210991 1.288184e-01 0.890 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.439203e-01 0.842 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.439203e-01 0.842 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 1.238418e-01 0.907 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.238418e-01 0.907 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.880356e-01 0.726 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.880356e-01 0.726 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 1.502330e-01 0.823 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 1.893256e-01 0.723 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.893256e-01 0.723 0 0
Signaling by ERBB4 R-HSA-1236394 1.375485e-01 0.862 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 1.682089e-01 0.774 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.742534e-01 0.759 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 1.880356e-01 0.726 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.787313e-01 0.748 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.134806e-01 0.945 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.144859e-01 0.941 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.070202e-01 0.971 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.597422e-01 0.797 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.742534e-01 0.759 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.599794e-01 0.796 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.033621e-01 0.986 0 0
Regulation of CDH11 function R-HSA-9762292 1.480041e-01 0.830 0 0
DNA strand elongation R-HSA-69190 1.939950e-01 0.712 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.422095e-01 0.847 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.215724e-01 0.915 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.252874e-01 0.902 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.252874e-01 0.902 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.145585e-01 0.941 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.856155e-01 0.731 0 0
Downstream TCR signaling R-HSA-202424 1.400417e-01 0.854 0 0
Interleukin-2 signaling R-HSA-9020558 1.722905e-01 0.764 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 1.597422e-01 0.797 0 0
Netrin-1 signaling R-HSA-373752 1.649769e-01 0.783 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.115748e-01 0.952 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 1.502330e-01 0.823 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 1.933302e-01 0.714 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.139991e-01 0.943 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.139991e-01 0.943 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 1.599794e-01 0.796 0 0
Pyrophosphate hydrolysis R-HSA-71737 1.599794e-01 0.796 0 0
Adrenoceptors R-HSA-390696 1.033621e-01 0.986 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.249560e-01 0.903 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.070202e-01 0.971 0 0
Fanconi Anemia Pathway R-HSA-6783310 1.769655e-01 0.752 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 2.020375e-01 0.695 0 0
TCR signaling R-HSA-202403 1.242178e-01 0.906 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.933302e-01 0.714 0 0
Integration of energy metabolism R-HSA-163685 1.076948e-01 0.968 0 0
Negative regulation of MET activity R-HSA-6807004 1.144859e-01 0.941 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 1.068198e-01 0.971 0 0
Protein methylation R-HSA-8876725 1.308286e-01 0.883 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.917603e-01 0.717 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 1.145585e-01 0.941 0 0
Interleukin-1 family signaling R-HSA-446652 1.072946e-01 0.969 0 0
Inhibition of PKR R-HSA-169131 1.840914e-01 0.735 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 1.599794e-01 0.796 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 1.961462e-01 0.707 0 0
Signaling by APC mutants R-HSA-4839744 1.722905e-01 0.764 0 0
Signaling by AXIN mutants R-HSA-4839735 1.976015e-01 0.704 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 1.880356e-01 0.726 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.367372e-01 0.864 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.502330e-01 0.823 0 0
Antigen processing-Cross presentation R-HSA-1236975 1.120602e-01 0.951 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.336317e-01 0.874 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.076948e-01 0.968 0 0
PECAM1 interactions R-HSA-210990 1.722905e-01 0.764 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 1.115748e-01 0.952 0 0
NRAGE signals death through JNK R-HSA-193648 1.230563e-01 0.910 0 0
Prolonged ERK activation events R-HSA-169893 1.490272e-01 0.827 0 0
PCP/CE pathway R-HSA-4086400 1.726914e-01 0.763 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.006402e-01 0.698 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.017698e-01 0.992 0 0
Signaling by FGFR2 R-HSA-5654738 1.201189e-01 0.920 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 1.230563e-01 0.910 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.139991e-01 0.943 0 0
Hemostasis R-HSA-109582 1.640470e-01 0.785 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.480041e-01 0.830 0 0
Hedgehog 'on' state R-HSA-5632684 1.872087e-01 0.728 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 1.938159e-01 0.713 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.961462e-01 0.707 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 1.490272e-01 0.827 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 1.111977e-01 0.954 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 1.288184e-01 0.890 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.489787e-01 0.827 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 1.961462e-01 0.707 0 0
Ion homeostasis R-HSA-5578775 1.230563e-01 0.910 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.975284e-01 0.704 0 0
Syndecan interactions R-HSA-3000170 1.762310e-01 0.754 0 0
Hedgehog ligand biogenesis R-HSA-5358346 1.525372e-01 0.817 0 0
Pyruvate metabolism R-HSA-70268 1.183661e-01 0.927 0 0
Signaling by NTRKs R-HSA-166520 1.855895e-01 0.731 0 0
Sensory processing of sound R-HSA-9659379 1.129725e-01 0.947 0 0
Specification of primordial germ cells R-HSA-9827857 1.880356e-01 0.726 0 0
FLT3 Signaling R-HSA-9607240 1.210834e-01 0.917 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.599794e-01 0.796 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.961462e-01 0.707 0 0
Signaling by ALK R-HSA-201556 1.923051e-01 0.716 0 0
Regulation of BACH1 activity R-HSA-9708530 1.490272e-01 0.827 0 0
Glycogen storage diseases R-HSA-3229121 1.880356e-01 0.726 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 1.597422e-01 0.797 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 2.062763e-01 0.686 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.086469e-01 0.681 0 0
GAB1 signalosome R-HSA-180292 2.086469e-01 0.681 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.086469e-01 0.681 0 0
Mismatch Repair R-HSA-5358508 2.086469e-01 0.681 0 0
Platelet sensitization by LDL R-HSA-432142 2.086469e-01 0.681 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 2.086469e-01 0.681 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.095526e-01 0.679 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.095526e-01 0.679 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 2.095526e-01 0.679 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 2.095526e-01 0.679 0 0
Tight junction interactions R-HSA-420029 2.109809e-01 0.676 0 0
Interleukin-7 signaling R-HSA-1266695 2.109809e-01 0.676 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.120173e-01 0.674 0 0
Gluconeogenesis R-HSA-70263 2.150805e-01 0.667 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.206168e-01 0.656 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 2.206168e-01 0.656 0 0
tRNA processing R-HSA-72306 2.212045e-01 0.655 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 2.237298e-01 0.650 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.237298e-01 0.650 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.237298e-01 0.650 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.237298e-01 0.650 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.237298e-01 0.650 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.237298e-01 0.650 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.237298e-01 0.650 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.237298e-01 0.650 0 0
Ion channel transport R-HSA-983712 2.271431e-01 0.644 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.291227e-01 0.640 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 2.291227e-01 0.640 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 2.291227e-01 0.640 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 2.295549e-01 0.639 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.298615e-01 0.639 0 0
The NLRP3 inflammasome R-HSA-844456 2.298615e-01 0.639 0 0
G2/M DNA replication checkpoint R-HSA-69478 2.331785e-01 0.632 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 2.331785e-01 0.632 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 2.331785e-01 0.632 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.331785e-01 0.632 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.418855e-01 0.616 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 2.418855e-01 0.616 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 2.476940e-01 0.606 0 0
Cristae formation R-HSA-8949613 2.476940e-01 0.606 0 0
Regulated Necrosis R-HSA-5218859 2.502193e-01 0.602 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 2.515783e-01 0.599 0 0
Protein hydroxylation R-HSA-9629569 2.515783e-01 0.599 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 2.515783e-01 0.599 0 0
Glycogen synthesis R-HSA-3322077 2.515783e-01 0.599 0 0
Oncogene Induced Senescence R-HSA-2559585 2.585775e-01 0.587 0 0
Transmission across Chemical Synapses R-HSA-112315 2.628128e-01 0.580 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 2.630159e-01 0.580 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 2.630159e-01 0.580 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.630159e-01 0.580 0 0
IKBKB deficiency causes SCID R-HSA-5602636 2.630159e-01 0.580 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.630159e-01 0.580 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 2.630159e-01 0.580 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 2.630159e-01 0.580 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.630159e-01 0.580 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.630159e-01 0.580 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 2.630159e-01 0.580 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.630159e-01 0.580 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.630159e-01 0.580 0 0
Generic Transcription Pathway R-HSA-212436 2.641817e-01 0.578 0 0
TBC/RABGAPs R-HSA-8854214 2.655545e-01 0.576 0 0
Signaling by FGFR4 R-HSA-5654743 2.655545e-01 0.576 0 0
Response of Mtb to phagocytosis R-HSA-9637690 2.655545e-01 0.576 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 2.666331e-01 0.574 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.701134e-01 0.568 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 2.701134e-01 0.568 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.705709e-01 0.568 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 2.705709e-01 0.568 0 0
PTK6 Expression R-HSA-8849473 2.705709e-01 0.568 0 0
IFNG signaling activates MAPKs R-HSA-9732724 2.705709e-01 0.568 0 0
SOS-mediated signalling R-HSA-112412 2.705709e-01 0.568 0 0
CHL1 interactions R-HSA-447041 2.705709e-01 0.568 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 2.705709e-01 0.568 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.705709e-01 0.568 0 0
Lagging Strand Synthesis R-HSA-69186 2.736984e-01 0.563 0 0
G-protein activation R-HSA-202040 2.736984e-01 0.563 0 0
ERK/MAPK targets R-HSA-198753 2.736984e-01 0.563 0 0
Early Phase of HIV Life Cycle R-HSA-162594 2.736984e-01 0.563 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 2.736984e-01 0.563 0 0
G1/S-Specific Transcription R-HSA-69205 2.755631e-01 0.560 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.776584e-01 0.556 0 0
Removal of the Flap Intermediate R-HSA-69166 2.776584e-01 0.556 0 0
Signal regulatory protein family interactions R-HSA-391160 2.776584e-01 0.556 0 0
Amine ligand-binding receptors R-HSA-375280 2.810695e-01 0.551 0 0
Metabolism of proteins R-HSA-392499 2.810725e-01 0.551 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.844687e-01 0.546 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.844687e-01 0.546 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 2.858783e-01 0.544 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.858783e-01 0.544 0 0
Mitochondrial protein import R-HSA-1268020 2.864830e-01 0.543 0 0
Heme signaling R-HSA-9707616 2.864830e-01 0.543 0 0
Signaling by MET R-HSA-6806834 2.879220e-01 0.541 0 0
Mitochondrial calcium ion transport R-HSA-8949215 2.961251e-01 0.529 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.961251e-01 0.529 0 0
Signaling by FGFR3 R-HSA-5654741 2.967996e-01 0.528 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.967996e-01 0.528 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 2.997144e-01 0.523 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.050992e-01 0.516 0 0
G beta:gamma signalling through BTK R-HSA-8964315 3.050992e-01 0.516 0 0
Processive synthesis on the lagging strand R-HSA-69183 3.050992e-01 0.516 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 3.050992e-01 0.516 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 3.050992e-01 0.516 0 0
Formation of the anterior neural plate R-HSA-9823739 3.050992e-01 0.516 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 3.053688e-01 0.515 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 3.053688e-01 0.515 0 0
Regulation by c-FLIP R-HSA-3371378 3.079077e-01 0.512 0 0
Dimerization of procaspase-8 R-HSA-69416 3.079077e-01 0.512 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.079077e-01 0.512 0 0
Signaling by TGFBR3 R-HSA-9839373 3.127132e-01 0.505 0 0
Regulation of pyruvate metabolism R-HSA-9861718 3.127132e-01 0.505 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 3.187658e-01 0.497 0 0
Signaling by FGFR R-HSA-190236 3.205727e-01 0.494 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.262747e-01 0.486 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 3.278560e-01 0.484 0 0
FOXO-mediated transcription R-HSA-9614085 3.318666e-01 0.479 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 3.326404e-01 0.478 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 3.326404e-01 0.478 0 0
Defective PAPSS2 causes SEMD-PA R-HSA-3560796 3.343100e-01 0.476 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.343100e-01 0.476 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.343100e-01 0.476 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 3.343100e-01 0.476 0 0
Potassium transport channels R-HSA-1296067 3.343100e-01 0.476 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 3.343100e-01 0.476 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 3.343100e-01 0.476 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 3.343100e-01 0.476 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.343100e-01 0.476 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.343100e-01 0.476 0 0
DSCAM interactions R-HSA-376172 3.343100e-01 0.476 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.343100e-01 0.476 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 3.343100e-01 0.476 0 0
Interferon alpha/beta signaling R-HSA-909733 3.370041e-01 0.472 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 3.399508e-01 0.469 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 3.415317e-01 0.467 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.448499e-01 0.462 0 0
Lipophagy R-HSA-9613354 3.448499e-01 0.462 0 0
MAPK1 (ERK2) activation R-HSA-112411 3.448499e-01 0.462 0 0
CASP8 activity is inhibited R-HSA-5218900 3.448499e-01 0.462 0 0
ALK mutants bind TKIs R-HSA-9700645 3.448499e-01 0.462 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.448499e-01 0.462 0 0
Unwinding of DNA R-HSA-176974 3.448499e-01 0.462 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 3.448499e-01 0.462 0 0
Regulated proteolysis of p75NTR R-HSA-193692 3.448499e-01 0.462 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.448499e-01 0.462 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 3.448499e-01 0.462 0 0
ARMS-mediated activation R-HSA-170984 3.448499e-01 0.462 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.448499e-01 0.462 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.448499e-01 0.462 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.449641e-01 0.462 0 0
NGF-stimulated transcription R-HSA-9031628 3.449641e-01 0.462 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.495405e-01 0.457 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.556993e-01 0.449 0 0
Rab regulation of trafficking R-HSA-9007101 3.581637e-01 0.446 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 3.601372e-01 0.444 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 3.601372e-01 0.444 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 3.601372e-01 0.444 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 3.601372e-01 0.444 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 3.634127e-01 0.440 0 0
Deadenylation of mRNA R-HSA-429947 3.643389e-01 0.438 0 0
Integrin signaling R-HSA-354192 3.647253e-01 0.438 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.647253e-01 0.438 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.737233e-01 0.427 0 0
Extension of Telomeres R-HSA-180786 3.737233e-01 0.427 0 0
ABC transporter disorders R-HSA-5619084 3.793313e-01 0.421 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 3.795469e-01 0.421 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 3.811247e-01 0.419 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 3.811247e-01 0.419 0 0
2-LTR circle formation R-HSA-164843 3.811247e-01 0.419 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 3.811247e-01 0.419 0 0
Receptor Mediated Mitophagy R-HSA-8934903 3.811247e-01 0.419 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 3.811247e-01 0.419 0 0
Signal attenuation R-HSA-74749 3.811247e-01 0.419 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.811247e-01 0.419 0 0
Signaling by Leptin R-HSA-2586552 3.811247e-01 0.419 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 3.846197e-01 0.415 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 3.846197e-01 0.415 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 3.846197e-01 0.415 0 0
TGFBR3 expression R-HSA-9839394 3.871086e-01 0.412 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.874588e-01 0.412 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.874588e-01 0.412 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 3.874588e-01 0.412 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 3.874588e-01 0.412 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 3.874588e-01 0.412 0 0
Axonal growth stimulation R-HSA-209563 3.987112e-01 0.399 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 3.987112e-01 0.399 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 3.987112e-01 0.399 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 3.987112e-01 0.399 0 0
MET activates PTPN11 R-HSA-8865999 3.987112e-01 0.399 0 0
FasL/ CD95L signaling R-HSA-75157 3.987112e-01 0.399 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 3.987112e-01 0.399 0 0
Intracellular oxygen transport R-HSA-8981607 3.987112e-01 0.399 0 0
Histamine receptors R-HSA-390650 3.987112e-01 0.399 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 3.991507e-01 0.399 0 0
RSV-host interactions R-HSA-9833110 4.010381e-01 0.397 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 4.040771e-01 0.394 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 4.044812e-01 0.393 0 0
Signal amplification R-HSA-392518 4.044812e-01 0.393 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 4.097677e-01 0.387 0 0
Suppression of phagosomal maturation R-HSA-9637687 4.097677e-01 0.387 0 0
Neurexins and neuroligins R-HSA-6794361 4.103011e-01 0.387 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 4.144889e-01 0.382 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 4.144889e-01 0.382 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.165157e-01 0.380 0 0
Formation of the posterior neural plate R-HSA-9832991 4.165157e-01 0.380 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 4.165157e-01 0.380 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.165157e-01 0.380 0 0
LGI-ADAM interactions R-HSA-5682910 4.165157e-01 0.380 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 4.242615e-01 0.372 0 0
Signalling to ERKs R-HSA-187687 4.242615e-01 0.372 0 0
Adipogenesis R-HSA-9843745 4.270594e-01 0.370 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.322483e-01 0.364 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 4.322483e-01 0.364 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.322483e-01 0.364 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 4.322483e-01 0.364 0 0
Insulin processing R-HSA-264876 4.322483e-01 0.364 0 0
Proteasome assembly R-HSA-9907900 4.347721e-01 0.362 0 0
Ca2+ pathway R-HSA-4086398 4.409050e-01 0.356 0 0
Germ layer formation at gastrulation R-HSA-9754189 4.411248e-01 0.355 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 4.411248e-01 0.355 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 4.411248e-01 0.355 0 0
E2F mediated regulation of DNA replication R-HSA-113510 4.411248e-01 0.355 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 4.411942e-01 0.355 0 0
RET signaling R-HSA-8853659 4.439151e-01 0.353 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 4.464465e-01 0.350 0 0
Neuronal System R-HSA-112316 4.476769e-01 0.349 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.508545e-01 0.346 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 4.508545e-01 0.346 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 4.508545e-01 0.346 0 0
Integration of provirus R-HSA-162592 4.508545e-01 0.346 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 4.508545e-01 0.346 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 4.508545e-01 0.346 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 4.524527e-01 0.344 0 0
Inflammasomes R-HSA-622312 4.544884e-01 0.342 0 0
ABC-family proteins mediated transport R-HSA-382556 4.555405e-01 0.341 0 0
HCN channels R-HSA-1296061 4.568853e-01 0.340 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.568853e-01 0.340 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.568853e-01 0.340 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.568853e-01 0.340 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.568853e-01 0.340 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.568853e-01 0.340 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.568853e-01 0.340 0 0
Regulation of gap junction activity R-HSA-191650 4.568853e-01 0.340 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 4.568853e-01 0.340 0 0
Alanine metabolism R-HSA-8964540 4.568853e-01 0.340 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.568853e-01 0.340 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.568853e-01 0.340 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 4.568853e-01 0.340 0 0
NADE modulates death signalling R-HSA-205025 4.568853e-01 0.340 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.568853e-01 0.340 0 0
Disorders of transmembrane transporters R-HSA-5619115 4.613475e-01 0.336 0 0
Mitochondrial biogenesis R-HSA-1592230 4.628209e-01 0.335 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.672771e-01 0.330 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 4.672771e-01 0.330 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.700041e-01 0.328 0 0
Signaling by FGFR1 R-HSA-5654736 4.752247e-01 0.323 0 0
DARPP-32 events R-HSA-180024 4.764317e-01 0.322 0 0
Glucagon-type ligand receptors R-HSA-420092 4.764317e-01 0.322 0 0
Regulation of gene expression in beta cells R-HSA-210745 4.764317e-01 0.322 0 0
MET promotes cell motility R-HSA-8875878 4.826751e-01 0.316 0 0
Repression of WNT target genes R-HSA-4641265 4.840134e-01 0.315 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.840134e-01 0.315 0 0
Leading Strand Synthesis R-HSA-69109 4.840134e-01 0.315 0 0
Polymerase switching R-HSA-69091 4.840134e-01 0.315 0 0
Maple Syrup Urine Disease R-HSA-9865114 4.840134e-01 0.315 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 4.840134e-01 0.315 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 4.840134e-01 0.315 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 4.840134e-01 0.315 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 4.840134e-01 0.315 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 4.840134e-01 0.315 0 0
Regulation of IFNG signaling R-HSA-877312 4.840134e-01 0.315 0 0
Signaling by LTK R-HSA-9842663 4.840134e-01 0.315 0 0
OAS antiviral response R-HSA-8983711 4.840134e-01 0.315 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 4.863941e-01 0.313 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 4.928689e-01 0.307 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 4.928689e-01 0.307 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 4.928689e-01 0.307 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 4.928689e-01 0.307 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 4.971276e-01 0.304 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.980275e-01 0.303 0 0
Interleukin-37 signaling R-HSA-9008059 4.980275e-01 0.303 0 0
Pentose phosphate pathway R-HSA-71336 5.017057e-01 0.300 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 5.017057e-01 0.300 0 0
RAS processing R-HSA-9648002 5.017057e-01 0.300 0 0
Plasma lipoprotein clearance R-HSA-8964043 5.017057e-01 0.300 0 0
GPER1 signaling R-HSA-9634597 5.046028e-01 0.297 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 5.070203e-01 0.295 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 5.094343e-01 0.293 0 0
G2 Phase R-HSA-68911 5.094343e-01 0.293 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.094343e-01 0.293 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.094343e-01 0.293 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 5.094343e-01 0.293 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 5.094343e-01 0.293 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 5.094343e-01 0.293 0 0
Co-inhibition by BTLA R-HSA-9927353 5.094343e-01 0.293 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 5.158995e-01 0.287 0 0
Formation of axial mesoderm R-HSA-9796292 5.158995e-01 0.287 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.158995e-01 0.287 0 0
Interleukin-6 signaling R-HSA-1059683 5.158995e-01 0.287 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 5.158995e-01 0.287 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.158995e-01 0.287 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 5.158995e-01 0.287 0 0
Serine metabolism R-HSA-977347 5.178350e-01 0.286 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 5.204580e-01 0.284 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 5.204580e-01 0.284 0 0
Glycogen metabolism R-HSA-8982491 5.204580e-01 0.284 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.265553e-01 0.279 0 0
Diseases of mitotic cell cycle R-HSA-9675126 5.400011e-01 0.268 0 0
Inwardly rectifying K+ channels R-HSA-1296065 5.400011e-01 0.268 0 0
Signaling by WNT in cancer R-HSA-4791275 5.400011e-01 0.268 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 5.400011e-01 0.268 0 0
MITF-M-dependent gene expression R-HSA-9856651 5.413544e-01 0.267 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 5.421214e-01 0.266 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 5.421214e-01 0.266 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 5.464486e-01 0.262 0 0
Malate-aspartate shuttle R-HSA-9856872 5.464486e-01 0.262 0 0
Physiological factors R-HSA-5578768 5.464486e-01 0.262 0 0
Regulation of insulin secretion R-HSA-422356 5.509517e-01 0.259 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 5.517045e-01 0.258 0 0
PDE3B signalling R-HSA-165160 5.569017e-01 0.254 0 0
PKB-mediated events R-HSA-109703 5.569017e-01 0.254 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.569017e-01 0.254 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.569017e-01 0.254 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.569017e-01 0.254 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 5.569017e-01 0.254 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 5.569017e-01 0.254 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 5.569017e-01 0.254 0 0
TRAIL signaling R-HSA-75158 5.569017e-01 0.254 0 0
Pentose phosphate pathway disease R-HSA-6791465 5.569017e-01 0.254 0 0
Synthesis of PS R-HSA-1483101 5.569017e-01 0.254 0 0
Phosphorylation of Emi1 R-HSA-176417 5.569017e-01 0.254 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.569017e-01 0.254 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 5.569017e-01 0.254 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.569017e-01 0.254 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.569017e-01 0.254 0 0
Signaling by MST1 R-HSA-8852405 5.569017e-01 0.254 0 0
VEGF ligand-receptor interactions R-HSA-194313 5.569017e-01 0.254 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 5.569017e-01 0.254 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 5.569017e-01 0.254 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 5.569017e-01 0.254 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 5.569017e-01 0.254 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 5.569017e-01 0.254 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 5.570096e-01 0.254 0 0
Translation of Structural Proteins R-HSA-9683701 5.570096e-01 0.254 0 0
Nuclear RNA decay R-HSA-9930044 5.603044e-01 0.252 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 5.656838e-01 0.247 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 5.656838e-01 0.247 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 5.656838e-01 0.247 0 0
Growth hormone receptor signaling R-HSA-982772 5.656838e-01 0.247 0 0
Protein localization R-HSA-9609507 5.704209e-01 0.244 0 0
DNA Damage Reversal R-HSA-73942 5.756210e-01 0.240 0 0
Transport and metabolism of PAPS R-HSA-174362 5.756210e-01 0.240 0 0
Biotin transport and metabolism R-HSA-196780 5.756210e-01 0.240 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 5.801107e-01 0.236 0 0
Thromboxane signalling through TP receptor R-HSA-428930 5.884875e-01 0.230 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 5.884875e-01 0.230 0 0
Signaling by SCF-KIT R-HSA-1433557 5.921243e-01 0.228 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 5.993950e-01 0.222 0 0
Calnexin/calreticulin cycle R-HSA-901042 5.993950e-01 0.222 0 0
Signaling by LTK in cancer R-HSA-9842640 5.997787e-01 0.222 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.997787e-01 0.222 0 0
Autointegration results in viral DNA circles R-HSA-177539 5.997787e-01 0.222 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 5.997787e-01 0.222 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 5.997787e-01 0.222 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 5.997787e-01 0.222 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 5.997787e-01 0.222 0 0
CREB phosphorylation R-HSA-199920 5.997787e-01 0.222 0 0
Nef and signal transduction R-HSA-164944 5.997787e-01 0.222 0 0
HDL clearance R-HSA-8964011 5.997787e-01 0.222 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 5.997787e-01 0.222 0 0
MET Receptor Activation R-HSA-6806942 5.997787e-01 0.222 0 0
Activation of SMO R-HSA-5635838 6.033971e-01 0.219 0 0
Attachment and Entry R-HSA-9678110 6.033971e-01 0.219 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.033971e-01 0.219 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 6.033971e-01 0.219 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.033971e-01 0.219 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.033971e-01 0.219 0 0
SLC transporter disorders R-HSA-5619102 6.067254e-01 0.217 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 6.105061e-01 0.214 0 0
G protein gated Potassium channels R-HSA-1296059 6.105061e-01 0.214 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 6.105061e-01 0.214 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 6.256424e-01 0.204 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 6.256424e-01 0.204 0 0
Interferon gamma signaling R-HSA-877300 6.263247e-01 0.203 0 0
Gastrulation R-HSA-9758941 6.283330e-01 0.202 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.297738e-01 0.201 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 6.297738e-01 0.201 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 6.317207e-01 0.199 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 6.317207e-01 0.199 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 6.363187e-01 0.196 0 0
RNA Polymerase III Transcription R-HSA-74158 6.363187e-01 0.196 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 6.363187e-01 0.196 0 0
RUNX2 regulates bone development R-HSA-8941326 6.363187e-01 0.196 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 6.385089e-01 0.195 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.385089e-01 0.195 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 6.385089e-01 0.195 0 0
Netrin mediated repulsion signals R-HSA-418886 6.385089e-01 0.195 0 0
Recycling of eIF2:GDP R-HSA-72731 6.385089e-01 0.195 0 0
DAG1 core M1 glycosylations R-HSA-8932506 6.385089e-01 0.195 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.385089e-01 0.195 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 6.385089e-01 0.195 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.385089e-01 0.195 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.385089e-01 0.195 0 0
Disinhibition of SNARE formation R-HSA-114516 6.385089e-01 0.195 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 6.385089e-01 0.195 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.385089e-01 0.195 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 6.385089e-01 0.195 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.385089e-01 0.195 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.385089e-01 0.195 0 0
Maturation of replicase proteins R-HSA-9694301 6.385089e-01 0.195 0 0
Diseases of DNA repair R-HSA-9675135 6.417645e-01 0.193 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 6.521194e-01 0.186 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 6.521194e-01 0.186 0 0
Signaling by BMP R-HSA-201451 6.521194e-01 0.186 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 6.547620e-01 0.184 0 0
Uptake and function of anthrax toxins R-HSA-5210891 6.547620e-01 0.184 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 6.556409e-01 0.183 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 6.709580e-01 0.173 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 6.709580e-01 0.173 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 6.716962e-01 0.173 0 0
HIV elongation arrest and recovery R-HSA-167287 6.716962e-01 0.173 0 0
Formation of the Early Elongation Complex R-HSA-113418 6.716962e-01 0.173 0 0
Pausing and recovery of HIV elongation R-HSA-167290 6.716962e-01 0.173 0 0
Telomere Extension By Telomerase R-HSA-171319 6.716962e-01 0.173 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 6.716962e-01 0.173 0 0
Pyroptosis R-HSA-5620971 6.716962e-01 0.173 0 0
Co-stimulation by CD28 R-HSA-389356 6.726801e-01 0.172 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 6.734931e-01 0.172 0 0
RSK activation R-HSA-444257 6.734931e-01 0.172 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.734931e-01 0.172 0 0
DAG1 core M2 glycosylations R-HSA-8932504 6.734931e-01 0.172 0 0
phospho-PLA2 pathway R-HSA-111995 6.734931e-01 0.172 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.734931e-01 0.172 0 0
MET receptor recycling R-HSA-8875656 6.734931e-01 0.172 0 0
Interleukin-9 signaling R-HSA-8985947 6.734931e-01 0.172 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.734931e-01 0.172 0 0
Fructose biosynthesis R-HSA-5652227 6.734931e-01 0.172 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 6.734931e-01 0.172 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 6.734931e-01 0.172 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 6.734931e-01 0.172 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.734931e-01 0.172 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 6.734931e-01 0.172 0 0
Sodium/Proton exchangers R-HSA-425986 6.734931e-01 0.172 0 0
Stimuli-sensing channels R-HSA-2672351 6.748680e-01 0.171 0 0
Regulation of beta-cell development R-HSA-186712 6.755856e-01 0.170 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 6.783832e-01 0.169 0 0
Polo-like kinase mediated events R-HSA-156711 6.783832e-01 0.169 0 0
PKA activation R-HSA-163615 6.783832e-01 0.169 0 0
Apoptotic factor-mediated response R-HSA-111471 6.783832e-01 0.169 0 0
PKA activation in glucagon signalling R-HSA-164378 6.783832e-01 0.169 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.783832e-01 0.169 0 0
Nephron development R-HSA-9831926 6.783832e-01 0.169 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 6.783832e-01 0.169 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 6.874000e-01 0.163 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 6.874000e-01 0.163 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 6.874586e-01 0.163 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 6.904508e-01 0.161 0 0
mRNA Capping R-HSA-72086 6.904508e-01 0.161 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 7.006681e-01 0.154 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 7.006681e-01 0.154 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 7.006681e-01 0.154 0 0
Specification of the neural plate border R-HSA-9834899 7.006681e-01 0.154 0 0
Maturation of nucleoprotein R-HSA-9694631 7.006681e-01 0.154 0 0
PI3K Cascade R-HSA-109704 7.017775e-01 0.154 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.022233e-01 0.154 0 0
Aquaporin-mediated transport R-HSA-445717 7.022233e-01 0.154 0 0
Formation of paraxial mesoderm R-HSA-9793380 7.022233e-01 0.154 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 7.032521e-01 0.153 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 7.032521e-01 0.153 0 0
HIV Transcription Elongation R-HSA-167169 7.032521e-01 0.153 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 7.032521e-01 0.153 0 0
Interleukin-2 family signaling R-HSA-451927 7.032521e-01 0.153 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.032521e-01 0.153 0 0
Diseases of Immune System R-HSA-5260271 7.032521e-01 0.153 0 0
Interleukin-21 signaling R-HSA-9020958 7.050936e-01 0.152 0 0
WNT mediated activation of DVL R-HSA-201688 7.050936e-01 0.152 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 7.050936e-01 0.152 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.050936e-01 0.152 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 7.050936e-01 0.152 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.050936e-01 0.152 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 7.050936e-01 0.152 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.050936e-01 0.152 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.050936e-01 0.152 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 7.050936e-01 0.152 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 7.050936e-01 0.152 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.050936e-01 0.152 0 0
Interleukin-1 processing R-HSA-448706 7.050936e-01 0.152 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.050936e-01 0.152 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.050936e-01 0.152 0 0
Cellular response to mitochondrial stress R-HSA-9840373 7.050936e-01 0.152 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.059858e-01 0.151 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 7.083874e-01 0.150 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.083874e-01 0.150 0 0
Metabolism of amino acids and derivatives R-HSA-71291 7.109799e-01 0.148 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 7.121916e-01 0.147 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 7.185143e-01 0.144 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 7.216539e-01 0.142 0 0
Co-inhibition by CTLA4 R-HSA-389513 7.216539e-01 0.142 0 0
Creatine metabolism R-HSA-71288 7.216539e-01 0.142 0 0
Signaling by NODAL R-HSA-1181150 7.216539e-01 0.142 0 0
Formation of definitive endoderm R-HSA-9823730 7.216539e-01 0.142 0 0
Leishmania phagocytosis R-HSA-9664417 7.242375e-01 0.140 0 0
Parasite infection R-HSA-9664407 7.242375e-01 0.140 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 7.242375e-01 0.140 0 0
Molecules associated with elastic fibres R-HSA-2129379 7.255142e-01 0.139 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 7.331888e-01 0.135 0 0
HIV Transcription Initiation R-HSA-167161 7.331888e-01 0.135 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 7.331888e-01 0.135 0 0
Signaling by FGFR1 in disease R-HSA-5655302 7.331888e-01 0.135 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.336373e-01 0.135 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.336373e-01 0.135 0 0
Formation of apoptosome R-HSA-111458 7.336373e-01 0.135 0 0
Binding and entry of HIV virion R-HSA-173107 7.336373e-01 0.135 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 7.336373e-01 0.135 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.336373e-01 0.135 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.336373e-01 0.135 0 0
Interleukin-27 signaling R-HSA-9020956 7.336373e-01 0.135 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 7.355683e-01 0.133 0 0
Iron uptake and transport R-HSA-917937 7.383557e-01 0.132 0 0
IGF1R signaling cascade R-HSA-2428924 7.393331e-01 0.131 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 7.413833e-01 0.130 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 7.418433e-01 0.130 0 0
Amino acids regulate mTORC1 R-HSA-9639288 7.419600e-01 0.130 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 7.509396e-01 0.124 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 7.573895e-01 0.121 0 0
FGFR1 mutant receptor activation R-HSA-1839124 7.573895e-01 0.121 0 0
DAG1 core M3 glycosylations R-HSA-8932505 7.594198e-01 0.120 0 0
vRNP Assembly R-HSA-192905 7.594198e-01 0.120 0 0
vRNA Synthesis R-HSA-192814 7.594198e-01 0.120 0 0
Bicarbonate transporters R-HSA-425381 7.594198e-01 0.120 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 7.594198e-01 0.120 0 0
Chylomicron assembly R-HSA-8963888 7.594198e-01 0.120 0 0
Suppression of apoptosis R-HSA-9635465 7.594198e-01 0.120 0 0
Transport of RCbl within the body R-HSA-9758890 7.594198e-01 0.120 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.594198e-01 0.120 0 0
Translation of Structural Proteins R-HSA-9694635 7.597853e-01 0.119 0 0
Attachment and Entry R-HSA-9694614 7.599029e-01 0.119 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.607948e-01 0.119 0 0
FCERI mediated NF-kB activation R-HSA-2871837 7.639822e-01 0.117 0 0
G alpha (z) signalling events R-HSA-418597 7.664472e-01 0.116 0 0
Effects of PIP2 hydrolysis R-HSA-114508 7.721703e-01 0.112 0 0
Signaling by KIT in disease R-HSA-9669938 7.772620e-01 0.109 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 7.772620e-01 0.109 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 7.772620e-01 0.109 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 7.772620e-01 0.109 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.827081e-01 0.106 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 7.827081e-01 0.106 0 0
ERKs are inactivated R-HSA-202670 7.827081e-01 0.106 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 7.827081e-01 0.106 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 7.827081e-01 0.106 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 7.827081e-01 0.106 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 7.827081e-01 0.106 0 0
Transcription of the HIV genome R-HSA-167172 7.834878e-01 0.106 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.861291e-01 0.105 0 0
Somitogenesis R-HSA-9824272 7.861291e-01 0.105 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 7.862052e-01 0.104 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 7.862052e-01 0.104 0 0
eNOS activation R-HSA-203615 7.862052e-01 0.104 0 0
IRS-mediated signalling R-HSA-112399 7.891291e-01 0.103 0 0
Interleukin receptor SHC signaling R-HSA-912526 7.935117e-01 0.100 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 7.935117e-01 0.100 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 7.979696e-01 0.098 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 7.979696e-01 0.098 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 7.995157e-01 0.097 0 0
PERK regulates gene expression R-HSA-381042 7.995157e-01 0.097 0 0
COPII-mediated vesicle transport R-HSA-204005 8.033278e-01 0.095 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.037433e-01 0.095 0 0
Interleukin-15 signaling R-HSA-8983432 8.037433e-01 0.095 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 8.037433e-01 0.095 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.037433e-01 0.095 0 0
Interleukin-35 Signalling R-HSA-8984722 8.037433e-01 0.095 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.037433e-01 0.095 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.037433e-01 0.095 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.037433e-01 0.095 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.042992e-01 0.095 0 0
Interleukin-6 family signaling R-HSA-6783589 8.087040e-01 0.092 0 0
Mitochondrial RNA degradation R-HSA-9836573 8.087040e-01 0.092 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.087040e-01 0.092 0 0
Complex III assembly R-HSA-9865881 8.087040e-01 0.092 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 8.087040e-01 0.092 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.092748e-01 0.092 0 0
Peroxisomal protein import R-HSA-9033241 8.100562e-01 0.091 0 0
GPVI-mediated activation cascade R-HSA-114604 8.121243e-01 0.090 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.125735e-01 0.090 0 0
Cardiac conduction R-HSA-5576891 8.133200e-01 0.090 0 0
tRNA Aminoacylation R-HSA-379724 8.198814e-01 0.086 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.198814e-01 0.086 0 0
Post-translational protein modification R-HSA-597592 8.209826e-01 0.086 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 8.227433e-01 0.085 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 8.227433e-01 0.085 0 0
Processing of SMDT1 R-HSA-8949664 8.227433e-01 0.085 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.227433e-01 0.085 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.227433e-01 0.085 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 8.227433e-01 0.085 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.227433e-01 0.085 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.227433e-01 0.085 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.227433e-01 0.085 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.227433e-01 0.085 0 0
Maturation of nucleoprotein R-HSA-9683610 8.227433e-01 0.085 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 8.228914e-01 0.085 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 8.228914e-01 0.085 0 0
Laminin interactions R-HSA-3000157 8.228914e-01 0.085 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.228914e-01 0.085 0 0
Hyaluronan degradation R-HSA-2160916 8.228914e-01 0.085 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.240547e-01 0.084 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.283429e-01 0.082 0 0
Mitochondrial protein degradation R-HSA-9837999 8.283429e-01 0.082 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 8.353315e-01 0.078 0 0
Elastic fibre formation R-HSA-1566948 8.353315e-01 0.078 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.353315e-01 0.078 0 0
MET activates PTK2 signaling R-HSA-8874081 8.361259e-01 0.078 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 8.361259e-01 0.078 0 0
TRP channels R-HSA-3295583 8.361259e-01 0.078 0 0
Urea cycle R-HSA-70635 8.361259e-01 0.078 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 8.383006e-01 0.077 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 8.399049e-01 0.076 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.399049e-01 0.076 0 0
cGMP effects R-HSA-418457 8.399049e-01 0.076 0 0
Hydrolysis of LPC R-HSA-1483115 8.399049e-01 0.076 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.399049e-01 0.076 0 0
Signaling by FGFR4 in disease R-HSA-5655291 8.399049e-01 0.076 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.399049e-01 0.076 0 0
HDL assembly R-HSA-8963896 8.399049e-01 0.076 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.399049e-01 0.076 0 0
Zinc transporters R-HSA-435354 8.399049e-01 0.076 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 8.438974e-01 0.074 0 0
Platelet homeostasis R-HSA-418346 8.461300e-01 0.073 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.467310e-01 0.072 0 0
Neddylation R-HSA-8951664 8.469983e-01 0.072 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.484590e-01 0.071 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.484590e-01 0.071 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 8.484590e-01 0.071 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 8.484590e-01 0.071 0 0
Insulin receptor signalling cascade R-HSA-74751 8.551449e-01 0.068 0 0
Erythropoietin activates RAS R-HSA-9027284 8.554059e-01 0.068 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.554059e-01 0.068 0 0
p38MAPK events R-HSA-171007 8.554059e-01 0.068 0 0
Other semaphorin interactions R-HSA-416700 8.554059e-01 0.068 0 0
Generation of second messenger molecules R-HSA-202433 8.560243e-01 0.068 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 8.560243e-01 0.068 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 8.599412e-01 0.066 0 0
Insulin receptor recycling R-HSA-77387 8.599412e-01 0.066 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.599412e-01 0.066 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.617581e-01 0.065 0 0
Integrin cell surface interactions R-HSA-216083 8.688025e-01 0.061 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.694068e-01 0.061 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.694068e-01 0.061 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.694068e-01 0.061 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 8.694068e-01 0.061 0 0
Killing mechanisms R-HSA-9664420 8.694068e-01 0.061 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.694068e-01 0.061 0 0
Phosphorylation of the APC/C R-HSA-176412 8.694068e-01 0.061 0 0
Atorvastatin ADME R-HSA-9754706 8.694068e-01 0.061 0 0
Leishmania infection R-HSA-9658195 8.698039e-01 0.061 0 0
Parasitic Infection Pathways R-HSA-9824443 8.698039e-01 0.061 0 0
Signaling by Erythropoietin R-HSA-9006335 8.706216e-01 0.060 0 0
Innate Immune System R-HSA-168249 8.743878e-01 0.058 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.744048e-01 0.058 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.805478e-01 0.055 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 8.805478e-01 0.055 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 8.812581e-01 0.055 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 8.820527e-01 0.055 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 8.820527e-01 0.055 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 8.820527e-01 0.055 0 0
Fibronectin matrix formation R-HSA-1566977 8.820527e-01 0.055 0 0
Passive transport by Aquaporins R-HSA-432047 8.820527e-01 0.055 0 0
Galactose catabolism R-HSA-70370 8.820527e-01 0.055 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 8.820527e-01 0.055 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 8.820527e-01 0.055 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.827910e-01 0.054 0 0
Activation of GABAB receptors R-HSA-991365 8.827910e-01 0.054 0 0
GABA B receptor activation R-HSA-977444 8.827910e-01 0.054 0 0
PI Metabolism R-HSA-1483255 8.868112e-01 0.052 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.874431e-01 0.052 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.897655e-01 0.051 0 0
Trafficking of AMPA receptors R-HSA-399719 8.897655e-01 0.051 0 0
Cargo concentration in the ER R-HSA-5694530 8.897655e-01 0.051 0 0
Downstream signal transduction R-HSA-186763 8.897655e-01 0.051 0 0
Signaling by Insulin receptor R-HSA-74752 8.925619e-01 0.049 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 8.925619e-01 0.049 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.934748e-01 0.049 0 0
Sulfide oxidation to sulfate R-HSA-1614517 8.934748e-01 0.049 0 0
Choline catabolism R-HSA-6798163 8.934748e-01 0.049 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.024902e-01 0.045 0 0
ECM proteoglycans R-HSA-3000178 9.029614e-01 0.044 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 9.062504e-01 0.043 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 9.062504e-01 0.043 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.085293e-01 0.042 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.115469e-01 0.040 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.131094e-01 0.039 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 9.131094e-01 0.039 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.131094e-01 0.039 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.131094e-01 0.039 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.131094e-01 0.039 0 0
Resolution of D-Loop Structures R-HSA-5693537 9.135999e-01 0.039 0 0
Heme degradation R-HSA-189483 9.135999e-01 0.039 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.138156e-01 0.039 0 0
Metabolism of polyamines R-HSA-351202 9.142546e-01 0.039 0 0
Signaling by FGFR in disease R-HSA-1226099 9.188313e-01 0.037 0 0
Hyaluronan metabolism R-HSA-2142845 9.204058e-01 0.036 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.215254e-01 0.035 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 9.215254e-01 0.035 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 9.215254e-01 0.035 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 9.215254e-01 0.035 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 9.215254e-01 0.035 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.215254e-01 0.035 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.215254e-01 0.035 0 0
Pregnenolone biosynthesis R-HSA-196108 9.215254e-01 0.035 0 0
Metal ion SLC transporters R-HSA-425410 9.233774e-01 0.035 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.247354e-01 0.034 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.255910e-01 0.034 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.267044e-01 0.033 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.291267e-01 0.032 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.291267e-01 0.032 0 0
Signalling to RAS R-HSA-167044 9.291267e-01 0.032 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.291267e-01 0.032 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.291267e-01 0.032 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.291267e-01 0.032 0 0
Triglyceride catabolism R-HSA-163560 9.325302e-01 0.030 0 0
Glycosphingolipid transport R-HSA-9845576 9.325302e-01 0.030 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.359922e-01 0.029 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.359922e-01 0.029 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.359922e-01 0.029 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.359922e-01 0.029 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.359922e-01 0.029 0 0
The phototransduction cascade R-HSA-2514856 9.384244e-01 0.028 0 0
Formation of the cornified envelope R-HSA-6809371 9.398487e-01 0.027 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.421929e-01 0.026 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.421929e-01 0.026 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.421929e-01 0.026 0 0
Fructose metabolism R-HSA-5652084 9.421929e-01 0.026 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.421929e-01 0.026 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.477933e-01 0.023 0 0
Interleukin-20 family signaling R-HSA-8854691 9.477933e-01 0.023 0 0
Formation of the ureteric bud R-HSA-9830674 9.477933e-01 0.023 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.477933e-01 0.023 0 0
Carnitine shuttle R-HSA-200425 9.477933e-01 0.023 0 0
Biosynthesis of maresins R-HSA-9018682 9.477933e-01 0.023 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 9.477933e-01 0.023 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.477933e-01 0.023 0 0
G alpha (s) signalling events R-HSA-418555 9.483963e-01 0.023 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.517264e-01 0.021 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.528514e-01 0.021 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.556387e-01 0.020 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.560526e-01 0.020 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.574197e-01 0.019 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 9.574197e-01 0.019 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.574197e-01 0.019 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.574197e-01 0.019 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.574197e-01 0.019 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.574197e-01 0.019 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.592464e-01 0.018 0 0
Potassium Channels R-HSA-1296071 9.602640e-01 0.018 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 9.615457e-01 0.017 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.640830e-01 0.016 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.640830e-01 0.016 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.652720e-01 0.015 0 0
Triglyceride biosynthesis R-HSA-75109 9.652720e-01 0.015 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.652720e-01 0.015 0 0
Triglyceride metabolism R-HSA-8979227 9.662077e-01 0.015 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.662077e-01 0.015 0 0
Surfactant metabolism R-HSA-5683826 9.684573e-01 0.014 0 0
Prednisone ADME R-HSA-9757110 9.686375e-01 0.014 0 0
GABA receptor activation R-HSA-977443 9.686988e-01 0.014 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.710551e-01 0.013 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.716770e-01 0.012 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.716770e-01 0.012 0 0
Platelet calcium homeostasis R-HSA-418360 9.716770e-01 0.012 0 0
Neurotransmitter release cycle R-HSA-112310 9.723873e-01 0.012 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.723873e-01 0.012 0 0
Signaling by PDGF R-HSA-186797 9.731691e-01 0.012 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.732812e-01 0.012 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.743295e-01 0.011 0 0
DAP12 signaling R-HSA-2424491 9.744221e-01 0.011 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.744221e-01 0.011 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.744221e-01 0.011 0 0
Neurotransmitter clearance R-HSA-112311 9.744221e-01 0.011 0 0
Complex I biogenesis R-HSA-6799198 9.751704e-01 0.011 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.769013e-01 0.010 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.788783e-01 0.009 0 0
DAG1 glycosylations R-HSA-8931838 9.791403e-01 0.009 0 0
Collagen formation R-HSA-1474290 9.802618e-01 0.009 0 0
Cardiogenesis R-HSA-9733709 9.811624e-01 0.008 0 0
Recycling of bile acids and salts R-HSA-159418 9.811624e-01 0.008 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.812366e-01 0.008 0 0
Azathioprine ADME R-HSA-9748787 9.812366e-01 0.008 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.812366e-01 0.008 0 0
PPARA activates gene expression R-HSA-1989781 9.813783e-01 0.008 0 0
Kidney development R-HSA-9830369 9.818431e-01 0.008 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.828068e-01 0.008 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.829886e-01 0.007 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.829886e-01 0.007 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.829886e-01 0.007 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.832214e-01 0.007 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.833153e-01 0.007 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.835839e-01 0.007 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.837584e-01 0.007 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.838539e-01 0.007 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.846378e-01 0.007 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.846378e-01 0.007 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.846378e-01 0.007 0 0
Nucleotide biosynthesis R-HSA-8956320 9.855733e-01 0.006 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.861272e-01 0.006 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.861272e-01 0.006 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.861272e-01 0.006 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.861272e-01 0.006 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.874724e-01 0.005 0 0
Paracetamol ADME R-HSA-9753281 9.879047e-01 0.005 0 0
G alpha (q) signalling events R-HSA-416476 9.884647e-01 0.005 0 0
Voltage gated Potassium channels R-HSA-1296072 9.886871e-01 0.005 0 0
NCAM1 interactions R-HSA-419037 9.886871e-01 0.005 0 0
Lysine catabolism R-HSA-71064 9.886871e-01 0.005 0 0
Collagen chain trimerization R-HSA-8948216 9.886871e-01 0.005 0 0
Aspirin ADME R-HSA-9749641 9.887375e-01 0.005 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.896082e-01 0.005 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.897842e-01 0.004 0 0
Dectin-2 family R-HSA-5621480 9.898672e-01 0.004 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.907749e-01 0.004 0 0
Peptide hormone metabolism R-HSA-2980736 9.915197e-01 0.004 0 0
Tryptophan catabolism R-HSA-71240 9.916696e-01 0.004 0 0
RAB geranylgeranylation R-HSA-8873719 9.922411e-01 0.003 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.924775e-01 0.003 0 0
Maturation of spike protein R-HSA-9694548 9.924775e-01 0.003 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.924855e-01 0.003 0 0
Interleukin-10 signaling R-HSA-6783783 9.924855e-01 0.003 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.932072e-01 0.003 0 0
Intra-Golgi traffic R-HSA-6811438 9.932072e-01 0.003 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.936810e-01 0.003 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.936810e-01 0.003 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.938661e-01 0.003 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.945775e-01 0.002 0 0
Extracellular matrix organization R-HSA-1474244 9.948189e-01 0.002 0 0
DAP12 interactions R-HSA-2172127 9.949985e-01 0.002 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.949985e-01 0.002 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.949985e-01 0.002 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.954712e-01 0.002 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.954837e-01 0.002 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.958621e-01 0.002 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.969976e-01 0.001 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.969976e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.971204e-01 0.001 0 0
Metabolism of porphyrins R-HSA-189445 9.971204e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.975521e-01 0.001 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.977897e-01 0.001 0 0
Metabolism of steroids R-HSA-8957322 9.978548e-01 0.001 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.980003e-01 0.001 0 0
FCGR activation R-HSA-2029481 9.981721e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.983782e-01 0.001 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.984807e-01 0.001 0 0
Cholesterol biosynthesis R-HSA-191273 9.984807e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.986457e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.986735e-01 0.001 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.989186e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.989932e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.990762e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.991184e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.991994e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.993377e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.993511e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.995224e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.995688e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.996486e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.996827e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.997007e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.997135e-01 0.000 0 0
Keratinization R-HSA-6805567 9.997217e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.997669e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.998068e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.998071e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.998148e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.998600e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.998716e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.998859e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999695e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999701e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999819e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999819e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999853e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999854e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999897e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999905e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999912e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999924e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999928e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999953e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999957e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999963e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999965e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999973e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999975e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999976e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999991e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999992e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999992e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999993e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999994e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999996e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999997e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999998e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999998e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999999e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999999e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.999999e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways