ASK1

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
A5A3E0 T949 Sugiyama POTEF A26C1B TVAsSSSLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
A5A3E0 Y940 Sugiyama POTEF A26C1B ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
O00151 T80 Sugiyama PDLIM1 CLIM1 CLP36 NMTHLEAQNRIKGCTDNLtLtVARsEHKVWsPLVtEEGKRH
O15530 S394 EPSD|PSP PDPK1 PDK1 GNyDNLLSQFGCMQVSSSSssHsLsASDTGLPQRSGsNIEQ
O15530 S398 EPSD|PSP PDPK1 PDK1 NLLSQFGCMQVSSSSssHsLsASDTGLPQRSGsNIEQYIHD
O43423 T101 Sugiyama ANP32CP PP32R1 EKCPNLTHLYLSGNKIKDLstIEPLKQLENLKSLDLFNCEV
O60361 Y136 Sugiyama NME2P1 SLRFKPEELVDYKSCAHDWVyE___________________
O95626 T105 Sugiyama ANP32D PP32R2 EKCPNLIHLNLSGNKIKDLstIEPLKKLENLESLDLFTCEV
P02786 T143 Sugiyama TFRC yWDDLKRKLsEKLDstDFTGtIKLLNENsyVPREAGsQKDE
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P06733 Y44 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07858 T95 Sugiyama CTSB CPSB TEDLKLPAsFDAREQWPQCPtIKEIRDQGSCGSCWAFGAVE
P07900 S53 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P08238 Y301 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB ELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHF
P08238 Y305 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB tKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEG
P10809 T115 Sugiyama HSPD1 HSP60 AKLVQDVANNtNEEAGDGtttAtVLARSIAKEGFEKISKGA
P10809 T117 Sugiyama HSPD1 HSP60 LVQDVANNtNEEAGDGtttAtVLARSIAKEGFEKISKGANP
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142 T163 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142 T64 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FtDtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQ
P11142 T66 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P11142 Y41 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P13489 S178 Sugiyama RNH1 PRI RNH SCEPLASVLRAKPDFKELtVsNNDINEAGVRVLCQGLKDSP
P13639 T5 Sugiyama EEF2 EF2 ________________MVNFtVDQIRAIMDKKANIRNMsVI
P13667 T449 Sugiyama PDIA4 ERP70 ERP72 AATQFWRSKVLEVAKDFPEytFAIADEEDyAGEVKDLGLsE
P13667 Y458 Sugiyama PDIA4 ERP70 ERP72 VLEVAKDFPEytFAIADEEDyAGEVKDLGLsEsGEDVNAAI
P14618 T50 Sugiyama PKM OIP3 PK2 PK3 PKM2 MCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMIKsGMN
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17066 Y43 Sugiyama HSPA6 HSP70B' FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P22392 Y151 Sugiyama NME2 NM23B SLWFKPEELVDyKSCAHDWVyE___________________
P23588 S207 Sugiyama EIF4B DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P30086 Y169 Sugiyama PEBP1 PBP PEBP FKVAsFRKKyELRAPVAGtCyQAEWDDyVPKLyEQLsGK__
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34931 Y43 Sugiyama HSPA1L FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P38646 T116 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38936 S98 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1 LPtGPRRGRDELGGGRRPGtsPALLQGTAEEDHVDLsLSCT
P39687 T105 Sugiyama ANP32A C15orf1 LANP MAPM PHAP1 EKCPNLTHLNLsGNKIKDLstIEPLKKLENLKsLDLFNCEV
P45983 T183 EPSD|PSP MAPK8 JNK1 PRKM8 SAPK1 SAPK1C CTLKILDFGLARTAGtsFMMtPyVVtRyYRAPEVILGMGYK
P45983 Y185 EPSD|PSP MAPK8 JNK1 PRKM8 SAPK1 SAPK1C LKILDFGLARTAGtsFMMtPyVVtRyYRAPEVILGMGYKEN
P45985 T261 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP MAP2K4 JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1 GNIKLCDFGIsGQLVDsIAKtRDAGCRPyMAPERIDPSASR
P46734 S218 SIGNOR|EPSD|PSP MAP2K3 MEK3 MKK3 PRKMK3 SKK2 INKEGHVKMCDFGISGyLVDsVAKtMDAGCKPYMAPERINP
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P48741 Y43 Sugiyama HSPA7 HSP70B FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P52564 S207 EPSD|PSP MAP2K6 MEK6 MKK6 PRKMK6 SKK3 INALGQVKMCDFGISGyLVDsVAKtIDAGCKPyMAPERINP
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P54652 Y42 Sugiyama HSPA2 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P60174 T217 Sugiyama TPI1 TPI VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60660 T103 Sugiyama MYL6 QGtyEDyVEGLRVFDKEGNGtVMGAEIRHVLVtLGEKMTEE
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 T249 Sugiyama ACTB tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P60709 Y240 Sugiyama ACTB ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 T251 Sugiyama ACTA2 ACTSA ACTVS GIG46 tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62736 Y242 Sugiyama ACTA2 ACTSA ACTVS GIG46 ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62942 T7 Sugiyama FKBP1A FKBP1 FKBP12 ______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 T249 Sugiyama ACTG1 ACTG tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63261 Y240 Sugiyama ACTG1 ACTG ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 T250 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P63267 Y241 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 T251 Sugiyama ACTC1 ACTC tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032 Y242 Sugiyama ACTC1 ACTC ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 T251 Sugiyama ACTA1 ACTA tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133 Y242 Sugiyama ACTA1 ACTA ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68363 S439 Sugiyama TUBA1B SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q05682 T86 Sugiyama CALD1 CAD CDM VEVNAQNsVPDEEAKTTtTNtQVEGDDEAAFLERLARREER
Q13283 T241 Sugiyama G3BP1 G3BP ETAPEDAQKsssPAPADIAQtVQEDLRtFsWAsVtsKNLPP
Q14568 S53 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q15056 T100 Sugiyama EIF4H KIAA0038 WBSCR1 WSCR1 KFKGFCyVEFDEVDsLKEALtyDGALLGDRsLRVDIAEGRK
Q15691 S40 EPSD|PSP MAPRE1 MLAWINESLQLNLTKIEQLCsGAAYCQFMDMLFPGSIALKK
Q15691 T154 EPSD|PSP MAPRE1 EtAVAPsLVAPALNKPKKPLtsssAAPQRPIstQRTAAAPK
Q15691 T206 EPSD|PSP MAPRE1 VGNGDDEAAELMQQVNVLKLtVEDLEKERDFyFGKLRNIEL
Q16539 T180 EPSD|PSP MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A EDCELKILDFGLARHtDDEMtGyVAtRWYRAPEIMLNWMHY
Q16539 Y182 EPSD|PSP MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A CELKILDFGLARHtDDEMtGyVAtRWYRAPEIMLNWMHYNQ
Q562R1 T250 Sugiyama ACTBL2 RAAAssSPERsyELPDGQVItIGNERFRCPEAIFQPSFLGI
Q562R1 Y241 Sugiyama ACTBL2 ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q6S8J3 T949 Sugiyama POTEE A26C1A POTE2 tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q6S8J3 Y940 Sugiyama POTEE A26C1A POTE2 ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q6ZN16 T662 Sugiyama MAP3K15 ASK3 TLEYEYDHDANGERVVLGKGtYGIVYAGRDLSNQVRIAIKE
Q6ZN16 Y690 Sugiyama MAP3K15 ASK3 RDLSNQVRIAIKEIPERDSRySQPLHEEIALHKYLKHRNIV
Q71U36 S439 Sugiyama TUBA1A TUBA3 SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q8IUQ4 T235 PSP SIAH1 HUMSIAH RKQAENFAYRLELNGHRRRLtWEAtPRSIHEGIATAIMNSD
Q8IUQ4 T239 PSP SIAH1 HUMSIAH ENFAYRLELNGHRRRLtWEAtPRSIHEGIATAIMNSDCLVF
Q8IUQ4 T70 PSP SIAH1 HUMSIAH PPILQCQSGHLVCSNCRPKLtCCPtCRGPLGSIRNLAMEKV
Q8IUQ4 T74 PSP SIAH1 HUMSIAH QCQSGHLVCSNCRPKLtCCPtCRGPLGSIRNLAMEKVANSV
Q969S3 S314 SIGNOR|EPSD|PSP ZNF622 ZPR9 YLGEKVGVGKICLWCNEKGKsFYStEAVQAHMNDKSHCKLF
Q969S3 T318 SIGNOR|EPSD|PSP ZNF622 ZPR9 KVGVGKICLWCNEKGKsFYStEAVQAHMNDKSHCKLFTDGD
Q99683 S966 GPS6|ELM|iPTMNet|EPSD|PSP MAP3K5 ASK1 MAPKKK5 MEKK5 KTQPKLSALSAGsNEYLRsIsLPVPVLVEDtssssEYGsVs
Q99683 T690 Sugiyama MAP3K5 ASK1 MAPKKK5 MEKK5 LLEYDYEYDENGDRVVLGKGtYGIVYAGRDLSNQVRIAIKE
Q99683 T779 Sugiyama MAP3K5 ASK1 MAPKKK5 MEKK5 GGSLSALLRSKWGPLKDNEQtIGFYTKQILEGLKYLHDNQI
Q99683 T813 GPS6|SIGNOR|EPSD|PSP MAP3K5 ASK1 MAPKKK5 MEKK5 YLHDNQIVHRDIKGDNVLINtYSGVLKISDFGtSKRLAGIN
Q99683 T838 GPS6|SIGNOR|EPSD|PSP|Sugiyama MAP3K5 ASK1 MAPKKK5 MEKK5 LKISDFGtSKRLAGINPCTEtFTGtLQyMAPEIIDKGPRGY
Q99683 T842 GPS6|SIGNOR|EPSD|PSP|Sugiyama MAP3K5 ASK1 MAPKKK5 MEKK5 DFGtSKRLAGINPCTEtFTGtLQyMAPEIIDKGPRGYGKAA
Q99683 Y718 Sugiyama MAP3K5 ASK1 MAPKKK5 MEKK5 RDLSNQVRIAIKEIPERDSRySQPLHEEIALHKHLKHKNIV
Q99683 Y845 Sugiyama MAP3K5 ASK1 MAPKKK5 MEKK5 tSKRLAGINPCTEtFTGtLQyMAPEIIDKGPRGYGKAADIW
Q9BQE3 Y432 Sugiyama TUBA1C TUBA6 GMEEGEFSEAREDMAALEKDyEEVGADsADGEDEGEEy___
Q9BYX7 T249 Sugiyama POTEKP ACTBL3 FKSG30 MAASSSSVEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q9BYX7 Y240 Sugiyama POTEKP ACTBL3 FKSG30 ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9UER7 S176 SIGNOR|EPSD|PSP DAXX BING2 DAP6 SGNNPPTHLsLDPtNAENtAsQsPRtRGsRRQIQRLEQLLA
Q9UER7 S184 SIGNOR|EPSD|PSP DAXX BING2 DAP6 LsLDPtNAENtAsQsPRtRGsRRQIQRLEQLLALYVAEIRR
Q9Y3F4 S179 EPSD|PSP STRAP MAWD UNRIP LsADDKtVRLWDHATMtEVKsLNFNMSVSSMEYIPEGEILV
Q9Y3F4 T175 EPSD|PSP STRAP MAWD UNRIP DKQILsADDKtVRLWDHATMtEVKsLNFNMSVSSMEYIPEG
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.146571e-07 6.668 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.397403e-06 5.855 0 0
Mitotic Prometaphase R-HSA-68877 1.409657e-06 5.851 0 0
M Phase R-HSA-68886 1.010535e-06 5.995 0 0
Cell Cycle, Mitotic R-HSA-69278 1.169452e-06 5.932 0 0
Post NMDA receptor activation events R-HSA-438064 7.069556e-07 6.151 0 0
L1CAM interactions R-HSA-373760 1.975876e-06 5.704 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 5.522875e-06 5.258 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 5.502596e-06 5.259 0 0
Cell Cycle R-HSA-1640170 7.300677e-06 5.137 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.265559e-05 4.898 0 0
Axon guidance R-HSA-422475 1.255201e-05 4.901 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.363074e-05 4.865 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.519235e-05 4.818 0 0
Selective autophagy R-HSA-9663891 1.700302e-05 4.769 0 0
Protein folding R-HSA-391251 2.921654e-05 4.534 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 4.618873e-05 4.335 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 5.237966e-05 4.281 0 0
Nervous system development R-HSA-9675108 5.240686e-05 4.281 0 0
Cell-extracellular matrix interactions R-HSA-446353 7.878855e-05 4.104 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 9.225326e-05 4.035 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 1.266738e-04 3.897 0 0
Mitotic Prophase R-HSA-68875 1.460995e-04 3.835 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.734246e-04 3.761 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.905234e-04 3.720 0 0
Transport of connexons to the plasma membrane R-HSA-190872 2.197036e-04 3.658 0 0
Recycling pathway of L1 R-HSA-437239 2.160399e-04 3.665 0 0
Autophagy R-HSA-9612973 2.657059e-04 3.576 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 3.411366e-04 3.467 0 0
Separation of Sister Chromatids R-HSA-2467813 4.396255e-04 3.357 0 0
Cellular response to chemical stress R-HSA-9711123 4.329127e-04 3.364 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 6.263260e-04 3.203 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 6.681318e-04 3.175 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 7.252534e-04 3.140 0 0
Nuclear Envelope Breakdown R-HSA-2980766 7.101119e-04 3.149 0 0
RSK activation R-HSA-444257 7.479680e-04 3.126 0 0
Macroautophagy R-HSA-1632852 7.948231e-04 3.100 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 7.965690e-04 3.099 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 8.809532e-04 3.055 0 0
Apoptotic execution phase R-HSA-75153 9.049150e-04 3.043 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 9.600219e-04 3.018 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 9.745242e-04 3.011 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.928646e-04 3.003 0 0
Mitotic Anaphase R-HSA-68882 1.205757e-03 2.919 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.264687e-03 2.898 0 0
Cellular responses to stress R-HSA-2262752 1.250112e-03 2.903 1 0
Folding of actin by CCT/TriC R-HSA-390450 1.378931e-03 2.860 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.419101e-03 2.848 0 0
Signaling by Hippo R-HSA-2028269 1.347753e-03 2.870 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.419101e-03 2.848 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.529477e-03 2.815 0 0
Aggrephagy R-HSA-9646399 1.811437e-03 2.742 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.036157e-03 2.691 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.310218e-03 2.636 0 0
Signaling by WNT in cancer R-HSA-4791275 2.849157e-03 2.545 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.219688e-03 2.492 0 0
Signal Transduction R-HSA-162582 3.091174e-03 2.510 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 3.231833e-03 2.491 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.314923e-03 2.480 0 0
Signaling by WNT R-HSA-195721 3.337791e-03 2.477 0 0
Nuclear import of Rev protein R-HSA-180746 4.110429e-03 2.386 0 0
Transmission across Chemical Synapses R-HSA-112315 3.963604e-03 2.402 0 0
Neuronal System R-HSA-112316 3.968593e-03 2.401 0 0
Cellular responses to stimuli R-HSA-8953897 3.912028e-03 2.408 1 0
Gap junction assembly R-HSA-190861 4.110429e-03 2.386 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 5.301605e-03 2.276 0 0
PKR-mediated signaling R-HSA-9833482 5.301605e-03 2.276 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 5.663677e-03 2.247 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 5.663677e-03 2.247 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 5.663677e-03 2.247 0 0
Interleukin-7 signaling R-HSA-1266695 5.760907e-03 2.240 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 5.964018e-03 2.224 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 6.380078e-03 2.195 0 0
Meiosis R-HSA-1500620 7.468190e-03 2.127 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 7.731202e-03 2.112 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 7.805186e-03 2.108 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 8.674878e-03 2.062 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 8.169192e-03 2.088 0 0
G2/M Transition R-HSA-69275 8.710920e-03 2.060 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.803622e-03 2.055 0 0
Regulation of gene expression in beta cells R-HSA-210745 9.413768e-03 2.026 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 9.451190e-03 2.025 0 0
Mitotic G2-G2/M phases R-HSA-453274 9.451974e-03 2.024 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.052939e-02 1.978 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.173221e-02 1.931 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.173221e-02 1.931 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.181424e-02 1.928 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.156294e-02 1.937 0 0
Regulation of beta-cell development R-HSA-186712 1.183403e-02 1.927 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.210667e-02 1.917 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.210667e-02 1.917 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.472905e-02 1.832 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.472905e-02 1.832 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.472905e-02 1.832 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.441101e-02 1.841 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.441101e-02 1.841 0 0
HCMV Early Events R-HSA-9609690 1.292792e-02 1.888 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.347721e-02 1.870 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.299360e-02 1.886 0 0
Signaling by APC mutants R-HSA-4839744 1.472905e-02 1.832 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.344125e-02 1.872 0 0
RAB geranylgeranylation R-HSA-8873719 1.273873e-02 1.895 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.469559e-02 1.833 0 0
Regulation of TP53 Activity R-HSA-5633007 1.417121e-02 1.849 0 0
Signaling by VEGF R-HSA-194138 1.423907e-02 1.847 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.302515e-02 1.885 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.459988e-02 1.836 0 0
Gap junction trafficking R-HSA-190828 1.234847e-02 1.908 0 0
Kinesins R-HSA-983189 1.273873e-02 1.895 0 0
Gene Silencing by RNA R-HSA-211000 1.246134e-02 1.904 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.589248e-02 1.799 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.747207e-02 1.758 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 1.582618e-02 1.801 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 1.747207e-02 1.758 0 0
Mitophagy R-HSA-5205647 1.747207e-02 1.758 0 0
RAF activation R-HSA-5673000 1.747207e-02 1.758 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.747207e-02 1.758 0 0
Co-stimulation by CD28 R-HSA-389356 1.712191e-02 1.766 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.589248e-02 1.799 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.734614e-02 1.761 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.747207e-02 1.758 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.764748e-02 1.753 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.764748e-02 1.753 0 0
Signaling by AXIN mutants R-HSA-4839735 1.764748e-02 1.753 0 0
Activation of RAC1 R-HSA-428540 1.764748e-02 1.753 0 0
Gap junction trafficking and regulation R-HSA-157858 1.848879e-02 1.733 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 2.086457e-02 1.681 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.086457e-02 1.681 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.086457e-02 1.681 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.086457e-02 1.681 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.086457e-02 1.681 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.086457e-02 1.681 0 0
Notch-HLH transcription pathway R-HSA-350054 1.951457e-02 1.710 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.888677e-02 1.724 0 0
Developmental Biology R-HSA-1266738 2.061876e-02 1.686 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.093508e-02 1.679 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 2.183879e-02 1.661 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.241812e-02 1.649 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.241812e-02 1.649 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.282284e-02 1.642 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.445855e-02 1.612 0 0
Meiotic synapsis R-HSA-1221632 2.469966e-02 1.607 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.692060e-02 1.570 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.913400e-02 1.536 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 2.913400e-02 1.536 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 2.696779e-02 1.569 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.692060e-02 1.570 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 2.699068e-02 1.569 0 0
Cell junction organization R-HSA-446728 2.549960e-02 1.593 0 0
NrCAM interactions R-HSA-447038 2.696779e-02 1.569 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.913400e-02 1.536 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.692060e-02 1.570 0 0
Cellular Senescence R-HSA-2559583 3.116383e-02 1.506 1 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 3.543818e-02 1.451 0 0
Signaling by RNF43 mutants R-HSA-5340588 3.440754e-02 1.463 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.231227e-02 1.491 0 0
Packaging Of Telomere Ends R-HSA-171306 3.280470e-02 1.484 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 3.596490e-02 1.444 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 3.145910e-02 1.502 0 0
PKMTs methylate histone lysines R-HSA-3214841 3.145910e-02 1.502 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 3.145910e-02 1.502 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.440754e-02 1.463 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 3.231227e-02 1.491 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 3.280470e-02 1.484 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 3.596490e-02 1.444 0 0
Protein methylation R-HSA-8876725 3.231227e-02 1.491 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 3.440754e-02 1.463 0 0
MTOR signalling R-HSA-165159 3.644945e-02 1.438 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 3.502322e-02 1.456 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.145910e-02 1.502 0 0
Apoptosis R-HSA-109581 3.286916e-02 1.483 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 3.424111e-02 1.465 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 3.644945e-02 1.438 0 0
Depyrimidination R-HSA-73928 3.644945e-02 1.438 0 0
Programmed Cell Death R-HSA-5357801 3.671977e-02 1.435 0 0
Cell-Cell communication R-HSA-1500931 3.898728e-02 1.409 0 0
DNA methylation R-HSA-5334118 3.929488e-02 1.406 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 4.009023e-02 1.397 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 4.029180e-02 1.395 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 4.254170e-02 1.371 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 4.254170e-02 1.371 0 0
CREB phosphorylation R-HSA-199920 4.254170e-02 1.371 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 4.270513e-02 1.370 0 0
Disinhibition of SNARE formation R-HSA-114516 5.131190e-02 1.290 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 5.131190e-02 1.290 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 5.131190e-02 1.290 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.279490e-02 1.369 0 0
Mitotic Spindle Checkpoint R-HSA-69618 5.080788e-02 1.294 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 4.781700e-02 1.320 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 4.641282e-02 1.333 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 5.131190e-02 1.290 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 4.582854e-02 1.339 0 0
tRNA processing in the nucleus R-HSA-6784531 4.338513e-02 1.363 0 0
MECP2 regulates transcription factors R-HSA-9022707 5.131190e-02 1.290 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 4.706112e-02 1.327 0 0
Glycolysis R-HSA-70171 5.080788e-02 1.294 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 5.030448e-02 1.298 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 4.338513e-02 1.363 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 5.168378e-02 1.287 0 0
Platelet sensitization by LDL R-HSA-432142 5.168378e-02 1.287 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 5.245689e-02 1.280 0 0
Signaling by NOTCH R-HSA-157118 5.366265e-02 1.270 0 0
AURKA Activation by TPX2 R-HSA-8854518 5.392664e-02 1.268 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 5.392664e-02 1.268 0 0
Intraflagellar transport R-HSA-5620924 5.420344e-02 1.266 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 5.431289e-02 1.265 0 0
Integrin signaling R-HSA-354192 5.431289e-02 1.265 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 6.962258e-02 1.157 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 6.066300e-02 1.217 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 6.066300e-02 1.217 0 0
Signaling by NOTCH2 R-HSA-1980145 6.283171e-02 1.202 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 6.912483e-02 1.160 0 0
Peptide chain elongation R-HSA-156902 6.468919e-02 1.189 0 0
HCMV Infection R-HSA-9609646 6.901718e-02 1.161 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 5.973078e-02 1.224 0 0
Diseases of programmed cell death R-HSA-9645723 6.468919e-02 1.189 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 5.723065e-02 1.242 0 0
Meiotic recombination R-HSA-912446 6.466468e-02 1.189 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 5.929573e-02 1.227 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 6.066300e-02 1.217 0 0
ERK/MAPK targets R-HSA-198753 6.912483e-02 1.160 0 0
Adrenoceptors R-HSA-390696 6.066300e-02 1.217 0 0
Cellular response to heat stress R-HSA-3371556 5.919459e-02 1.228 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 6.471626e-02 1.189 0 0
Signaling by Hedgehog R-HSA-5358351 5.780934e-02 1.238 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 6.283171e-02 1.202 0 0
Influenza Infection R-HSA-168255 5.895367e-02 1.229 0 0
SARS-CoV-2-host interactions R-HSA-9705683 6.971167e-02 1.157 0 0
ARMS-mediated activation R-HSA-170984 7.054298e-02 1.152 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 7.054298e-02 1.152 0 0
GP1b-IX-V activation signalling R-HSA-430116 7.054298e-02 1.152 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 7.054298e-02 1.152 0 0
Lipophagy R-HSA-9613354 7.054298e-02 1.152 0 0
PRC2 methylates histones and DNA R-HSA-212300 7.200951e-02 1.143 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 7.545717e-02 1.122 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 7.545717e-02 1.122 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 7.545717e-02 1.122 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 7.617642e-02 1.118 0 0
Voltage gated Potassium channels R-HSA-1296072 7.684062e-02 1.114 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 7.684062e-02 1.114 0 0
Cleavage of the damaged purine R-HSA-110331 7.684062e-02 1.114 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 1.025975e-01 0.989 0 0
Defective SLC12A3 causes Gitelman syndrome (GS) R-HSA-5619087 1.025975e-01 0.989 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 1.025975e-01 0.989 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 1.025975e-01 0.989 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 1.025975e-01 0.989 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 1.025975e-01 0.989 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 8.090275e-02 1.092 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 8.090275e-02 1.092 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 8.885165e-02 1.051 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.031610e-01 0.986 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.031610e-01 0.986 0 0
HDACs deacetylate histones R-HSA-3214815 8.024418e-02 1.096 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.022658e-01 0.990 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 8.495374e-02 1.071 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 9.169603e-02 1.038 0 0
HDMs demethylate histones R-HSA-3214842 1.031610e-01 0.986 0 0
Interleukin-2 signaling R-HSA-9020558 9.169603e-02 1.038 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 1.028792e-01 0.988 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.596829e-02 1.018 0 0
Signaling by NOTCH3 R-HSA-9012852 8.024418e-02 1.096 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 1.025975e-01 0.989 0 0
Manipulation of host energy metabolism R-HSA-9636667 1.025975e-01 0.989 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 8.090275e-02 1.092 0 0
Ionotropic activity of kainate receptors R-HSA-451306 9.169603e-02 1.038 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.028792e-01 0.988 0 0
NF-kB is activated and signals survival R-HSA-209560 1.028792e-01 0.988 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 9.227340e-02 1.035 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 9.158453e-02 1.038 0 0
Long-term potentiation R-HSA-9620244 1.031610e-01 0.986 0 0
Carnitine shuttle R-HSA-200425 8.885165e-02 1.051 0 0
Cilium Assembly R-HSA-5617833 8.030306e-02 1.095 0 0
Signaling by Leptin R-HSA-2586552 8.090275e-02 1.092 0 0
Metabolism of non-coding RNA R-HSA-194441 9.764132e-02 1.010 0 0
snRNP Assembly R-HSA-191859 9.764132e-02 1.010 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 8.212271e-02 1.086 0 0
Receptor Mediated Mitophagy R-HSA-8934903 8.090275e-02 1.092 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.030774e-01 0.987 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.030774e-01 0.987 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.030774e-01 0.987 0 0
Cytokine Signaling in Immune system R-HSA-1280215 9.645117e-02 1.016 0 0
NTRK3 as a dependence receptor R-HSA-9603505 1.025975e-01 0.989 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 8.885165e-02 1.051 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.794924e-02 1.108 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.794924e-02 1.108 0 0
Reproduction R-HSA-1474165 8.603461e-02 1.065 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 8.442571e-02 1.074 0 0
Depurination R-HSA-73927 8.183008e-02 1.087 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.442571e-02 1.074 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.183008e-02 1.087 0 0
ISG15 antiviral mechanism R-HSA-1169408 8.285965e-02 1.082 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.022658e-01 0.990 0 0
Growth hormone receptor signaling R-HSA-982772 8.885165e-02 1.051 0 0
tRNA processing R-HSA-72306 8.495374e-02 1.071 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.719880e-02 1.012 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.033160e-01 0.986 0 0
Rab regulation of trafficking R-HSA-9007101 1.055474e-01 0.977 0 0
Glucose metabolism R-HSA-70326 1.055474e-01 0.977 0 0
FOXO-mediated transcription R-HSA-9614085 1.067364e-01 0.972 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.069974e-01 0.971 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 1.344056e-01 0.872 0 0
Potassium transport channels R-HSA-1296067 1.344056e-01 0.872 0 0
Defective SLC12A1 causes Bartter syndrome 1 (BS1) R-HSA-5619104 1.344056e-01 0.872 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 1.344056e-01 0.872 0 0
MET activates STAT3 R-HSA-8875791 1.650882e-01 0.782 0 0
Axonal growth stimulation R-HSA-209563 1.650882e-01 0.782 0 0
Signalling to STAT3 R-HSA-198745 1.650882e-01 0.782 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 1.650882e-01 0.782 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 1.650882e-01 0.782 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 1.650882e-01 0.782 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 1.650882e-01 0.782 0 0
NADE modulates death signalling R-HSA-205025 1.946850e-01 0.711 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.946850e-01 0.711 0 0
Defective MAT1A causes MATD R-HSA-5579024 1.946850e-01 0.711 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 1.946850e-01 0.711 0 0
Signaling by LRP5 mutants R-HSA-5339717 1.946850e-01 0.711 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 1.946850e-01 0.711 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 2.232343e-01 0.651 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.232343e-01 0.651 0 0
IRS activation R-HSA-74713 2.232343e-01 0.651 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.232343e-01 0.651 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 2.232343e-01 0.651 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 2.232343e-01 0.651 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.144112e-01 0.942 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.507732e-01 0.601 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.507732e-01 0.601 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 2.507732e-01 0.601 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.262534e-01 0.899 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.383693e-01 0.859 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.507249e-01 0.822 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 3.029613e-01 0.519 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.029613e-01 0.519 0 0
IFNG signaling activates MAPKs R-HSA-9732724 3.029613e-01 0.519 0 0
SOS-mediated signalling R-HSA-112412 3.029613e-01 0.519 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 3.029613e-01 0.519 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 1.889177e-01 0.724 0 0
phospho-PLA2 pathway R-HSA-111995 3.276782e-01 0.485 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.282237e-01 0.642 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.333651e-01 0.875 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.333651e-01 0.875 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.333651e-01 0.875 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 2.547304e-01 0.594 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 2.547304e-01 0.594 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.167752e-01 0.933 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.167752e-01 0.933 0 0
RET signaling R-HSA-8853659 2.040213e-01 0.690 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.269605e-01 0.896 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.132784e-01 0.671 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.540994e-01 0.812 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.714415e-01 0.766 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.607130e-01 0.584 0 0
Centrosome maturation R-HSA-380287 1.834035e-01 0.737 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.563879e-01 0.806 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.614068e-01 0.792 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.821524e-01 0.740 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.874981e-01 0.727 0 0
Viral mRNA Translation R-HSA-192823 2.322872e-01 0.634 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 2.618289e-01 0.582 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.678537e-01 0.572 0 0
Neutrophil degranulation R-HSA-6798695 1.493634e-01 0.826 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 1.277975e-01 0.893 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 2.414608e-01 0.617 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.274648e-01 0.643 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.106360e-01 0.956 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.232992e-01 0.909 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.879524e-01 0.541 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.265087e-01 0.645 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.383693e-01 0.859 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 1.424508e-01 0.846 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.265876e-01 0.898 0 0
p75NTR signals via NF-kB R-HSA-193639 1.507249e-01 0.822 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.462818e-01 0.835 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.019297e-01 0.695 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 3.276782e-01 0.485 0 0
MAP2K and MAPK activation R-HSA-5674135 2.607130e-01 0.584 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.648755e-01 0.783 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.648755e-01 0.783 0 0
Signaling by RAS mutants R-HSA-6802949 1.333651e-01 0.875 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.246611e-01 0.648 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.714415e-01 0.766 0 0
Chromatin organization R-HSA-4839726 1.796669e-01 0.746 0 0
Telomere C-strand synthesis initiation R-HSA-174430 1.507249e-01 0.822 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.183120e-01 0.927 0 0
Trafficking of AMPA receptors R-HSA-399719 1.508352e-01 0.821 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.714415e-01 0.766 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.439797e-01 0.613 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.439797e-01 0.613 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.144112e-01 0.942 0 0
Chromatin modifying enzymes R-HSA-3247509 3.128653e-01 0.505 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.871173e-01 0.542 0 0
GPVI-mediated activation cascade R-HSA-114604 2.040213e-01 0.690 0 0
TNFR1-mediated ceramide production R-HSA-5626978 1.946850e-01 0.711 0 0
PTK6 Activates STAT3 R-HSA-8849474 2.232343e-01 0.651 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 2.232343e-01 0.651 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 2.232343e-01 0.651 0 0
Activation of AKT2 R-HSA-165158 2.232343e-01 0.651 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.507249e-01 0.822 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.183120e-01 0.927 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 2.019297e-01 0.695 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.397634e-01 0.855 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 3.077756e-01 0.512 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.678537e-01 0.572 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.612767e-01 0.583 0 0
Adipogenesis R-HSA-9843745 2.829563e-01 0.548 0 0
Prolonged ERK activation events R-HSA-169893 1.632879e-01 0.787 0 0
DNA Double Strand Break Response R-HSA-5693606 2.870829e-01 0.542 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.322769e-01 0.634 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.322769e-01 0.634 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.322769e-01 0.634 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.322769e-01 0.634 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.540994e-01 0.812 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 1.946850e-01 0.711 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 2.507732e-01 0.601 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 1.507249e-01 0.822 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 2.282237e-01 0.642 0 0
Eukaryotic Translation Termination R-HSA-72764 1.874981e-01 0.727 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.739130e-01 0.562 0 0
Neurodegenerative Diseases R-HSA-8863678 2.945521e-01 0.531 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.945521e-01 0.531 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.145589e-01 0.668 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 2.773374e-01 0.557 0 0
Regulation of signaling by CBL R-HSA-912631 2.150395e-01 0.667 0 0
HSF1 activation R-HSA-3371511 2.040213e-01 0.690 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.597966e-01 0.796 0 0
NRAGE signals death through JNK R-HSA-193648 2.022317e-01 0.694 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.019297e-01 0.695 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.336883e-01 0.874 0 0
Regulated Necrosis R-HSA-5218859 2.950739e-01 0.530 0 0
Interleukin-2 family signaling R-HSA-451927 2.415433e-01 0.617 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 1.344056e-01 0.872 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.946850e-01 0.711 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.946850e-01 0.711 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.144112e-01 0.942 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 2.507732e-01 0.601 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.507732e-01 0.601 0 0
Ceramide signalling R-HSA-193681 2.507732e-01 0.601 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 2.507732e-01 0.601 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.262534e-01 0.899 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 2.773374e-01 0.557 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.632879e-01 0.787 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 3.029613e-01 0.519 0 0
Interleukin-23 signaling R-HSA-9020933 3.276782e-01 0.485 0 0
FGFR1b ligand binding and activation R-HSA-190370 3.276782e-01 0.485 0 0
RMTs methylate histone arginines R-HSA-3214858 1.209452e-01 0.917 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.734706e-01 0.761 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 3.209495e-01 0.494 0 0
Signaling by NOTCH4 R-HSA-9013694 1.773842e-01 0.751 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.462310e-01 0.835 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 3.029613e-01 0.519 0 0
Formation of the cornified envelope R-HSA-6809371 2.341209e-01 0.631 0 0
Signaling by NOTCH1 R-HSA-1980143 1.894970e-01 0.722 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.716489e-01 0.765 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 2.232343e-01 0.651 0 0
TRP channels R-HSA-3295583 1.106360e-01 0.956 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.276782e-01 0.485 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 2.415433e-01 0.617 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 2.415433e-01 0.617 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 3.191977e-01 0.496 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 2.941416e-01 0.531 0 0
Somitogenesis R-HSA-9824272 2.995491e-01 0.524 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.322769e-01 0.634 0 0
Muscarinic acetylcholine receptors R-HSA-390648 2.232343e-01 0.651 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.029613e-01 0.519 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.029613e-01 0.519 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.276782e-01 0.485 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.188805e-01 0.925 0 0
Opioid Signalling R-HSA-111885 2.381115e-01 0.623 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.112154e-01 0.954 0 0
Interleukin-9 signaling R-HSA-8985947 3.276782e-01 0.485 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.618289e-01 0.582 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.144112e-01 0.942 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.734706e-01 0.761 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.309549e-01 0.636 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 1.123309e-01 0.950 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.288743e-01 0.640 0 0
HCMV Late Events R-HSA-9610379 2.997266e-01 0.523 0 0
rRNA processing R-HSA-72312 3.041381e-01 0.517 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 1.229383e-01 0.910 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 1.123309e-01 0.950 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 1.229383e-01 0.910 0 0
Formation of paraxial mesoderm R-HSA-9793380 2.399550e-01 0.620 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.555759e-01 0.592 0 0
EPH-Ephrin signaling R-HSA-2682334 1.664943e-01 0.779 0 0
Signaling by ALK in cancer R-HSA-9700206 2.618289e-01 0.582 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.946850e-01 0.711 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 1.946850e-01 0.711 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.232343e-01 0.651 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 2.507732e-01 0.601 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 2.507732e-01 0.601 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.507249e-01 0.822 0 0
TRIF-mediated programmed cell death R-HSA-2562578 3.029613e-01 0.519 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 3.029613e-01 0.519 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 3.276782e-01 0.485 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 3.276782e-01 0.485 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.019297e-01 0.695 0 0
Defective pyroptosis R-HSA-9710421 1.149315e-01 0.940 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.680532e-01 0.775 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.812931e-01 0.551 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 2.945521e-01 0.531 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.805246e-01 0.743 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 3.093181e-01 0.510 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.405913e-01 0.619 0 0
Membrane Trafficking R-HSA-199991 1.804745e-01 0.744 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.104127e-01 0.957 0 0
Toll-like Receptor Cascades R-HSA-168898 2.313637e-01 0.636 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 1.508352e-01 0.821 0 0
ESR-mediated signaling R-HSA-8939211 3.260662e-01 0.487 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 1.513838e-01 0.820 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.507732e-01 0.601 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.262534e-01 0.899 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.703715e-01 0.568 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.507249e-01 0.822 0 0
Rap1 signalling R-HSA-392517 2.150395e-01 0.667 0 0
Signaling by FGFR1 in disease R-HSA-5655302 2.607130e-01 0.584 0 0
Selenocysteine synthesis R-HSA-2408557 2.207779e-01 0.656 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.680532e-01 0.775 0 0
Signaling by Interleukins R-HSA-449147 1.856194e-01 0.731 0 0
Metabolism of RNA R-HSA-8953854 3.069090e-01 0.513 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.760283e-01 0.754 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 1.694885e-01 0.771 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.818441e-01 0.740 0 0
Semaphorin interactions R-HSA-373755 2.554800e-01 0.593 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 1.836590e-01 0.736 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 1.836590e-01 0.736 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.554800e-01 0.593 0 0
Signaling by PTK6 R-HSA-8848021 2.554800e-01 0.593 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.733116e-01 0.761 0 0
Cell Cycle Checkpoints R-HSA-69620 2.096814e-01 0.678 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 1.946850e-01 0.711 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 1.946850e-01 0.711 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.232343e-01 0.651 0 0
Regulation of KIT signaling R-HSA-1433559 1.383693e-01 0.859 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 1.632879e-01 0.787 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 3.029613e-01 0.519 0 0
Regulation of PTEN localization R-HSA-8948747 3.029613e-01 0.519 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 3.276782e-01 0.485 0 0
Protein ubiquitination R-HSA-8852135 1.834035e-01 0.737 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.574186e-01 0.803 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.381115e-01 0.623 0 0
Ub-specific processing proteases R-HSA-5689880 2.606605e-01 0.584 0 0
Adaptive Immune System R-HSA-1280218 2.479415e-01 0.606 0 0
Estrogen-dependent gene expression R-HSA-9018519 3.167900e-01 0.499 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 3.209495e-01 0.494 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 3.190972e-01 0.496 0 0
Deubiquitination R-HSA-5688426 1.994382e-01 0.700 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.593655e-01 0.798 0 0
Signaling by SCF-KIT R-HSA-1433557 1.149315e-01 0.940 0 0
Co-inhibition by PD-1 R-HSA-389948 2.703145e-01 0.568 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.730709e-01 0.762 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 3.065177e-01 0.514 0 0
Adherens junctions interactions R-HSA-418990 1.572860e-01 0.803 0 0
Ca-dependent events R-HSA-111996 2.703715e-01 0.568 0 0
Cell-cell junction organization R-HSA-421270 2.770888e-01 0.557 0 0
Stimuli-sensing channels R-HSA-2672351 2.678537e-01 0.572 0 0
S Phase R-HSA-69242 2.538283e-01 0.595 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.496376e-01 0.825 0 0
Apoptotic factor-mediated response R-HSA-111471 2.019297e-01 0.695 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.232343e-01 0.651 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 2.507732e-01 0.601 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.507732e-01 0.601 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 2.507732e-01 0.601 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 2.507732e-01 0.601 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 1.632879e-01 0.787 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 3.029613e-01 0.519 0 0
Synthesis of PG R-HSA-1483148 1.760283e-01 0.754 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 3.276782e-01 0.485 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.680532e-01 0.775 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 1.470058e-01 0.833 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.342291e-01 0.872 0 0
Hedgehog 'off' state R-HSA-5610787 1.104642e-01 0.957 0 0
Base Excision Repair R-HSA-73884 1.514391e-01 0.820 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.118344e-01 0.951 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.609822e-01 0.793 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.609822e-01 0.793 0 0
Signaling by NTRKs R-HSA-166520 1.505873e-01 0.822 0 0
Inositol phosphate metabolism R-HSA-1483249 1.648755e-01 0.783 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 1.183120e-01 0.927 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 2.547304e-01 0.594 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.156514e-01 0.666 0 0
MAP kinase activation R-HSA-450294 2.399550e-01 0.620 0 0
Selenoamino acid metabolism R-HSA-2408522 2.154142e-01 0.667 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 1.262534e-01 0.899 0 0
Pentose phosphate pathway R-HSA-71336 2.320480e-01 0.634 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.245706e-01 0.649 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.270910e-01 0.896 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 2.232343e-01 0.651 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 2.507732e-01 0.601 0 0
Interleukin-17 signaling R-HSA-448424 3.111353e-01 0.507 0 0
Amine ligand-binding receptors R-HSA-375280 2.897969e-01 0.538 0 0
Hemostasis R-HSA-109582 1.497039e-01 0.825 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.019297e-01 0.695 0 0
Signaling by ROBO receptors R-HSA-376176 1.837100e-01 0.736 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 2.791238e-01 0.554 0 0
Interferon Signaling R-HSA-913531 2.138581e-01 0.670 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.029613e-01 0.519 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 1.760283e-01 0.754 0 0
Synaptic adhesion-like molecules R-HSA-8849932 2.019297e-01 0.695 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 3.077756e-01 0.512 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.540994e-01 0.812 0 0
Amyloid fiber formation R-HSA-977225 2.209829e-01 0.656 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 3.272759e-01 0.485 0 0
Kidney development R-HSA-9830369 2.870829e-01 0.542 0 0
Nephron development R-HSA-9831926 2.019297e-01 0.695 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 1.734706e-01 0.761 0 0
Formation of the nephric duct R-HSA-9830364 3.077756e-01 0.512 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.547304e-01 0.594 0 0
Mitochondrial calcium ion transport R-HSA-8949215 2.547304e-01 0.594 0 0
SLC transporter disorders R-HSA-5619102 1.368871e-01 0.864 0 0
FLT3 Signaling R-HSA-9607240 2.511010e-01 0.600 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 3.272759e-01 0.485 0 0
SARS-CoV Infections R-HSA-9679506 1.463522e-01 0.835 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 3.209495e-01 0.494 0 0
G-protein beta:gamma signalling R-HSA-397795 1.680532e-01 0.775 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.948618e-01 0.530 0 0
SARS-CoV-2 Infection R-HSA-9694516 2.629580e-01 0.580 0 0
Ribosome-associated quality control R-HSA-9948299 3.282303e-01 0.484 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.296791e-01 0.482 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.296791e-01 0.482 0 0
Muscle contraction R-HSA-397014 3.297003e-01 0.482 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 3.340606e-01 0.476 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 3.340606e-01 0.476 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.340606e-01 0.476 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 3.386592e-01 0.470 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 3.386592e-01 0.470 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 3.438570e-01 0.464 0 0
Potassium Channels R-HSA-1296071 3.438570e-01 0.464 0 0
Telomere Extension By Telomerase R-HSA-171319 3.470970e-01 0.460 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 3.470970e-01 0.460 0 0
Pyroptosis R-HSA-5620971 3.470970e-01 0.460 0 0
MAPK family signaling cascades R-HSA-5683057 3.488101e-01 0.457 0 0
Telomere Maintenance R-HSA-157579 3.509153e-01 0.455 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.515201e-01 0.454 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 3.515201e-01 0.454 0 0
Regulated proteolysis of p75NTR R-HSA-193692 3.515201e-01 0.454 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 3.515201e-01 0.454 0 0
p75NTR regulates axonogenesis R-HSA-193697 3.515201e-01 0.454 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 3.515201e-01 0.454 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.515201e-01 0.454 0 0
Unwinding of DNA R-HSA-176974 3.515201e-01 0.454 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 3.515201e-01 0.454 0 0
Interleukin-21 signaling R-HSA-9020958 3.515201e-01 0.454 0 0
Regulation of signaling by NODAL R-HSA-1433617 3.515201e-01 0.454 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.515201e-01 0.454 0 0
WNT mediated activation of DVL R-HSA-201688 3.515201e-01 0.454 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.515201e-01 0.454 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.515201e-01 0.454 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.515201e-01 0.454 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 3.581849e-01 0.446 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 3.596722e-01 0.444 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.600473e-01 0.444 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 3.600473e-01 0.444 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.600473e-01 0.444 0 0
DARPP-32 events R-HSA-180024 3.600473e-01 0.444 0 0
Chromosome Maintenance R-HSA-73886 3.612907e-01 0.442 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 3.650512e-01 0.438 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 3.679196e-01 0.434 0 0
Neurexins and neuroligins R-HSA-6794361 3.679196e-01 0.434 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 3.679196e-01 0.434 0 0
Disorders of transmembrane transporters R-HSA-5619115 3.708168e-01 0.431 0 0
Neddylation R-HSA-8951664 3.722159e-01 0.429 0 0
Activation of the pre-replicative complex R-HSA-68962 3.729015e-01 0.428 0 0
Neurotransmitter clearance R-HSA-112311 3.729015e-01 0.428 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.729015e-01 0.428 0 0
Activation of BH3-only proteins R-HSA-114452 3.729015e-01 0.428 0 0
MHC class II antigen presentation R-HSA-2132295 3.739935e-01 0.427 0 0
Regulation of CDH11 function R-HSA-9762292 3.745178e-01 0.427 0 0
PI3K/AKT activation R-HSA-198203 3.745178e-01 0.427 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 3.745178e-01 0.427 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 3.745178e-01 0.427 0 0
Signal attenuation R-HSA-74749 3.745178e-01 0.427 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 3.745178e-01 0.427 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 3.745178e-01 0.427 0 0
Pexophagy R-HSA-9664873 3.745178e-01 0.427 0 0
Interleukin-27 signaling R-HSA-9020956 3.745178e-01 0.427 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.745178e-01 0.427 0 0
Josephin domain DUBs R-HSA-5689877 3.745178e-01 0.427 0 0
Nuclear Receptor transcription pathway R-HSA-383280 3.758699e-01 0.425 0 0
G alpha (12/13) signalling events R-HSA-416482 3.758699e-01 0.425 0 0
RNA Polymerase I Transcription R-HSA-73864 3.758699e-01 0.425 0 0
Interleukin-1 signaling R-HSA-9020702 3.791970e-01 0.421 0 0
Host Interactions of HIV factors R-HSA-162909 3.803503e-01 0.420 0 0
Downstream signal transduction R-HSA-186763 3.856499e-01 0.414 0 0
ER to Golgi Anterograde Transport R-HSA-199977 3.861465e-01 0.413 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.862679e-01 0.413 1 1
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.862679e-01 0.413 0 0
Translation initiation complex formation R-HSA-72649 3.873051e-01 0.412 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 3.873051e-01 0.412 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 3.920307e-01 0.407 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 3.967014e-01 0.402 0 0
Bicarbonate transporters R-HSA-425381 3.967014e-01 0.402 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 3.967014e-01 0.402 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 3.967014e-01 0.402 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 3.967014e-01 0.402 0 0
G alpha (z) signalling events R-HSA-418597 3.969457e-01 0.401 0 0
Potential therapeutics for SARS R-HSA-9679191 4.036216e-01 0.394 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.065450e-01 0.391 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.065450e-01 0.391 0 0
Regulation of necroptotic cell death R-HSA-5675482 4.107960e-01 0.386 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 4.107960e-01 0.386 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 4.107960e-01 0.386 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 4.107960e-01 0.386 0 0
Regulation of CDH1 Function R-HSA-9764561 4.160986e-01 0.381 0 0
Synthesis of PA R-HSA-1483166 4.160986e-01 0.381 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.160986e-01 0.381 0 0
Plasmalogen biosynthesis R-HSA-75896 4.180995e-01 0.379 0 0
ERKs are inactivated R-HSA-202670 4.180995e-01 0.379 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 4.180995e-01 0.379 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.180995e-01 0.379 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 4.180995e-01 0.379 0 0
DNA Replication R-HSA-69306 4.210807e-01 0.376 0 0
Striated Muscle Contraction R-HSA-390522 4.231785e-01 0.373 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 4.231785e-01 0.373 0 0
Heme degradation R-HSA-189483 4.231785e-01 0.373 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.256019e-01 0.371 0 0
Death Receptor Signaling R-HSA-73887 4.268911e-01 0.370 0 0
Protein-protein interactions at synapses R-HSA-6794362 4.321073e-01 0.364 0 0
eNOS activation R-HSA-203615 4.354250e-01 0.361 0 0
NOD1/2 Signaling Pathway R-HSA-168638 4.354250e-01 0.361 0 0
Cardiac conduction R-HSA-5576891 4.374282e-01 0.359 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 4.387398e-01 0.358 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 4.387398e-01 0.358 0 0
Signaling by LTK R-HSA-9842663 4.387398e-01 0.358 0 0
Interleukin-15 signaling R-HSA-8983432 4.387398e-01 0.358 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 4.387398e-01 0.358 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 4.387398e-01 0.358 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 4.387398e-01 0.358 0 0
Interleukin-35 Signalling R-HSA-8984722 4.387398e-01 0.358 0 0
OAS antiviral response R-HSA-8983711 4.387398e-01 0.358 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 4.400436e-01 0.357 0 0
Regulation of PTEN gene transcription R-HSA-8943724 4.444415e-01 0.352 0 0
Glutathione conjugation R-HSA-156590 4.444415e-01 0.352 0 0
Signaling by ERBB2 R-HSA-1227986 4.444415e-01 0.352 0 0
Signalling to ERKs R-HSA-187687 4.475296e-01 0.349 0 0
Cellular response to starvation R-HSA-9711097 4.500545e-01 0.347 0 0
Generic Transcription Pathway R-HSA-212436 4.511544e-01 0.346 0 0
PLC beta mediated events R-HSA-112043 4.537700e-01 0.343 0 0
Adenylate cyclase activating pathway R-HSA-170660 4.586493e-01 0.339 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.586493e-01 0.339 0 0
CD28 dependent Vav1 pathway R-HSA-389359 4.586493e-01 0.339 0 0
Frs2-mediated activation R-HSA-170968 4.586493e-01 0.339 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 4.586493e-01 0.339 0 0
FGFR1c ligand binding and activation R-HSA-190373 4.586493e-01 0.339 0 0
Interleukin-6 signaling R-HSA-1059683 4.586493e-01 0.339 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 4.586493e-01 0.339 0 0
Calmodulin induced events R-HSA-111933 4.594870e-01 0.338 0 0
CaM pathway R-HSA-111997 4.594870e-01 0.338 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.712924e-01 0.327 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 4.712924e-01 0.327 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 4.722268e-01 0.326 0 0
Prolactin receptor signaling R-HSA-1170546 4.778537e-01 0.321 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 4.778537e-01 0.321 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.778537e-01 0.321 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 4.778537e-01 0.321 0 0
Hydrolysis of LPC R-HSA-1483115 4.778537e-01 0.321 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 4.778537e-01 0.321 0 0
Acyl chain remodeling of CL R-HSA-1482798 4.778537e-01 0.321 0 0
Zinc transporters R-HSA-435354 4.778537e-01 0.321 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.813486e-01 0.318 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 4.829415e-01 0.316 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 4.829415e-01 0.316 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 4.829415e-01 0.316 0 0
Viral Infection Pathways R-HSA-9824446 4.856495e-01 0.314 0 0
PTEN Regulation R-HSA-6807070 4.934886e-01 0.307 0 0
Signaling by ALK R-HSA-201556 4.944306e-01 0.306 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 4.944306e-01 0.306 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 4.963779e-01 0.304 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 4.963779e-01 0.304 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 4.963779e-01 0.304 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 4.963779e-01 0.304 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 4.963779e-01 0.304 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 4.963779e-01 0.304 0 0
Erythropoietin activates RAS R-HSA-9027284 4.963779e-01 0.304 0 0
Synthesis of 12-eicosatetraenoic acid derivatives R-HSA-2142712 4.963779e-01 0.304 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 4.963779e-01 0.304 0 0
Signaling by Activin R-HSA-1502540 4.963779e-01 0.304 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 4.963779e-01 0.304 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 4.963779e-01 0.304 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 4.963779e-01 0.304 0 0
Spry regulation of FGF signaling R-HSA-1295596 4.963779e-01 0.304 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 4.963779e-01 0.304 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 4.963779e-01 0.304 0 0
DCC mediated attractive signaling R-HSA-418885 4.963779e-01 0.304 0 0
mRNA Splicing - Major Pathway R-HSA-72163 5.029473e-01 0.298 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 5.057563e-01 0.296 0 0
Diseases of Immune System R-HSA-5260271 5.057563e-01 0.296 0 0
Glycogen metabolism R-HSA-8982491 5.057563e-01 0.296 0 0
G-protein mediated events R-HSA-112040 5.082515e-01 0.294 0 0
Gene expression (Transcription) R-HSA-74160 5.087510e-01 0.293 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 5.142461e-01 0.289 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.142461e-01 0.289 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.142461e-01 0.289 0 0
Killing mechanisms R-HSA-9664420 5.142461e-01 0.289 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 5.142461e-01 0.289 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 5.142461e-01 0.289 0 0
Negative regulation of FLT3 R-HSA-9706369 5.142461e-01 0.289 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 5.142461e-01 0.289 0 0
Activation of SMO R-HSA-5635838 5.142461e-01 0.289 0 0
Attachment and Entry R-HSA-9678110 5.142461e-01 0.289 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 5.169159e-01 0.287 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.169159e-01 0.287 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 5.170563e-01 0.286 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 5.174856e-01 0.286 0 0
Late Phase of HIV Life Cycle R-HSA-162599 5.178204e-01 0.286 0 0
Vesicle-mediated transport R-HSA-5653656 5.195325e-01 0.284 0 0
Clathrin-mediated endocytosis R-HSA-8856828 5.238335e-01 0.281 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 5.246730e-01 0.280 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 5.279068e-01 0.277 0 0
Intra-Golgi traffic R-HSA-6811438 5.279068e-01 0.277 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 5.279068e-01 0.277 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 5.314814e-01 0.275 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 5.314814e-01 0.275 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 5.314814e-01 0.275 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 5.314814e-01 0.275 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 5.314814e-01 0.275 0 0
Scavenging by Class B Receptors R-HSA-3000471 5.314814e-01 0.275 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.314814e-01 0.275 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.314814e-01 0.275 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 5.314814e-01 0.275 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 5.314814e-01 0.275 0 0
Disorders of Developmental Biology R-HSA-9675151 5.314814e-01 0.275 0 0
Galactose catabolism R-HSA-70370 5.314814e-01 0.275 0 0
tRNA modification in the mitochondrion R-HSA-6787450 5.314814e-01 0.275 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 5.320698e-01 0.274 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.344075e-01 0.272 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 5.394092e-01 0.268 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.429498e-01 0.265 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.429498e-01 0.265 0 0
Hedgehog 'on' state R-HSA-5632684 5.429498e-01 0.265 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 5.457046e-01 0.263 0 0
Synthesis of 15-eicosatetraenoic acid derivatives R-HSA-2142770 5.481061e-01 0.261 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 5.481061e-01 0.261 0 0
TBC/RABGAPs R-HSA-8854214 5.493747e-01 0.260 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 5.514008e-01 0.259 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 5.514008e-01 0.259 0 0
Post-translational protein phosphorylation R-HSA-8957275 5.539106e-01 0.257 0 0
mRNA Splicing R-HSA-72172 5.594693e-01 0.252 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 5.641419e-01 0.249 0 0
PKA activation in glucagon signalling R-HSA-164378 5.641419e-01 0.249 0 0
FGFR1 ligand binding and activation R-HSA-190242 5.641419e-01 0.249 0 0
PKA activation R-HSA-163615 5.641419e-01 0.249 0 0
Ephrin signaling R-HSA-3928664 5.641419e-01 0.249 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 5.641419e-01 0.249 0 0
G2/M DNA damage checkpoint R-HSA-69473 5.680220e-01 0.246 0 0
Signaling by FGFR in disease R-HSA-1226099 5.680220e-01 0.246 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.701476e-01 0.244 0 0
Nucleosome assembly R-HSA-774815 5.701476e-01 0.244 0 0
DAG and IP3 signaling R-HSA-1489509 5.701476e-01 0.244 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 5.751985e-01 0.240 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 5.761892e-01 0.239 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 5.761892e-01 0.239 0 0
Interleukin-1 family signaling R-HSA-446652 5.764845e-01 0.239 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 5.764845e-01 0.239 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 5.796096e-01 0.237 0 0
Pyrimidine biosynthesis R-HSA-500753 5.796096e-01 0.237 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 5.796096e-01 0.237 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 5.796096e-01 0.237 0 0
STING mediated induction of host immune responses R-HSA-1834941 5.796096e-01 0.237 0 0
Translesion Synthesis by POLH R-HSA-110320 5.796096e-01 0.237 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 5.796096e-01 0.237 0 0
The NLRP3 inflammasome R-HSA-844456 5.796096e-01 0.237 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 5.796096e-01 0.237 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 5.796096e-01 0.237 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 5.796096e-01 0.237 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 5.802710e-01 0.236 0 0
Signaling by TGFBR3 R-HSA-9839373 5.802710e-01 0.236 0 0
Platelet degranulation R-HSA-114608 5.817358e-01 0.235 0 0
DNA Double-Strand Break Repair R-HSA-5693532 5.821555e-01 0.235 0 0
UCH proteinases R-HSA-5689603 5.842592e-01 0.233 0 0
Immune System R-HSA-168256 5.939377e-01 0.226 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 5.945293e-01 0.226 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 5.945293e-01 0.226 0 0
Signaling by NODAL R-HSA-1181150 5.945293e-01 0.226 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 5.945293e-01 0.226 0 0
Acyl chain remodelling of PI R-HSA-1482922 5.945293e-01 0.226 0 0
Nephrin family interactions R-HSA-373753 5.945293e-01 0.226 0 0
Signal transduction by L1 R-HSA-445144 5.945293e-01 0.226 0 0
Negative regulation of MET activity R-HSA-6807004 5.945293e-01 0.226 0 0
Glycogen synthesis R-HSA-3322077 5.945293e-01 0.226 0 0
Response of endothelial cells to shear stress R-HSA-9860931 5.959012e-01 0.225 0 0
Metal ion SLC transporters R-HSA-425410 5.999888e-01 0.222 0 0
PCP/CE pathway R-HSA-4086400 6.001029e-01 0.222 0 0
HIV Life Cycle R-HSA-162587 6.044454e-01 0.219 0 0
Post-translational protein modification R-HSA-597592 6.065879e-01 0.217 0 0
Sensory processing of sound R-HSA-9659379 6.078747e-01 0.216 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 6.089204e-01 0.215 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 6.089204e-01 0.215 0 0
G-protein activation R-HSA-202040 6.089204e-01 0.215 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.089204e-01 0.215 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 6.089204e-01 0.215 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 6.089204e-01 0.215 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 6.089204e-01 0.215 0 0
Basigin interactions R-HSA-210991 6.089204e-01 0.215 0 0
Acyl chain remodelling of PG R-HSA-1482925 6.089204e-01 0.215 0 0
Degradation of CDH1 R-HSA-9766229 6.095831e-01 0.215 0 0
DNA Damage Bypass R-HSA-73893 6.095831e-01 0.215 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 6.099161e-01 0.215 0 0
DNA Repair R-HSA-73894 6.145709e-01 0.211 0 0
PI3K Cascade R-HSA-109704 6.190011e-01 0.208 0 0
Azathioprine ADME R-HSA-9748787 6.190011e-01 0.208 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 6.228016e-01 0.206 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.228016e-01 0.206 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 6.228016e-01 0.206 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 6.228016e-01 0.206 0 0
Glutathione synthesis and recycling R-HSA-174403 6.228016e-01 0.206 0 0
Attachment and Entry R-HSA-9694614 6.228016e-01 0.206 0 0
Signaling by PDGFR in disease R-HSA-9671555 6.228016e-01 0.206 0 0
Processing of DNA double-strand break ends R-HSA-5693607 6.231141e-01 0.205 0 0
Ion channel transport R-HSA-983712 6.238232e-01 0.205 0 0
HSF1-dependent transactivation R-HSA-3371571 6.282433e-01 0.202 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 6.361909e-01 0.196 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 6.361909e-01 0.196 0 0
FGFR2 alternative splicing R-HSA-6803529 6.361909e-01 0.196 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 6.361909e-01 0.196 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 6.361909e-01 0.196 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 6.361909e-01 0.196 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 6.361909e-01 0.196 0 0
Signaling by KIT in disease R-HSA-9669938 6.361909e-01 0.196 0 0
mTORC1-mediated signalling R-HSA-166208 6.361909e-01 0.196 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 6.361909e-01 0.196 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 6.361909e-01 0.196 0 0
Cytoprotection by HMOX1 R-HSA-9707564 6.379441e-01 0.195 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 6.462030e-01 0.190 0 0
Smooth Muscle Contraction R-HSA-445355 6.462030e-01 0.190 0 0
Regulation of PTEN stability and activity R-HSA-8948751 6.462030e-01 0.190 0 0
Integration of energy metabolism R-HSA-163685 6.467575e-01 0.189 0 0
Interleukin receptor SHC signaling R-HSA-912526 6.491056e-01 0.188 0 0
Interleukin-20 family signaling R-HSA-8854691 6.491056e-01 0.188 0 0
Biosynthesis of maresins R-HSA-9018682 6.491056e-01 0.188 0 0
Formation of the ureteric bud R-HSA-9830674 6.491056e-01 0.188 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 6.491056e-01 0.188 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 6.491056e-01 0.188 0 0
Syndecan interactions R-HSA-3000170 6.491056e-01 0.188 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.501097e-01 0.187 0 0
CYP2E1 reactions R-HSA-211999 6.615627e-01 0.179 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.615627e-01 0.179 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 6.615627e-01 0.179 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 6.615627e-01 0.179 0 0
Deadenylation of mRNA R-HSA-429947 6.615627e-01 0.179 0 0
Interleukin-6 family signaling R-HSA-6783589 6.615627e-01 0.179 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 6.615627e-01 0.179 0 0
TNFs bind their physiological receptors R-HSA-5669034 6.615627e-01 0.179 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 6.634690e-01 0.178 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 6.664326e-01 0.176 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 6.718448e-01 0.173 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 6.718448e-01 0.173 0 0
TNF signaling R-HSA-75893 6.718448e-01 0.173 0 0
Signaling by FGFR1 R-HSA-5654736 6.718448e-01 0.173 0 0
Signaling by EGFR R-HSA-177929 6.718448e-01 0.173 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 6.724083e-01 0.172 0 0
Interleukin-12 family signaling R-HSA-447115 6.732090e-01 0.172 0 0
Acyl chain remodelling of PS R-HSA-1482801 6.735783e-01 0.172 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 6.735783e-01 0.172 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 6.741188e-01 0.171 0 0
IRS-mediated signalling R-HSA-112399 6.800507e-01 0.167 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 6.850844e-01 0.164 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 6.851680e-01 0.164 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 6.851680e-01 0.164 0 0
Dual incision in TC-NER R-HSA-6782135 6.880885e-01 0.162 0 0
Downstream TCR signaling R-HSA-202424 6.931233e-01 0.159 0 0
Mitochondrial biogenesis R-HSA-1592230 6.955679e-01 0.158 0 0
Extension of Telomeres R-HSA-180786 6.959596e-01 0.157 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.959596e-01 0.157 0 0
Cristae formation R-HSA-8949613 6.963469e-01 0.157 0 0
Signaling by BMP R-HSA-201451 6.963469e-01 0.157 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 6.963469e-01 0.157 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 6.963469e-01 0.157 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 6.963469e-01 0.157 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 6.963469e-01 0.157 0 0
Maturation of hRSV A proteins R-HSA-9828806 6.963469e-01 0.157 0 0
Homology Directed Repair R-HSA-5693538 7.011714e-01 0.154 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.067004e-01 0.151 0 0
Keratinization R-HSA-6805567 7.068742e-01 0.151 0 0
Inflammasomes R-HSA-622312 7.071295e-01 0.151 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 7.071295e-01 0.151 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.112087e-01 0.148 0 0
Thyroxine biosynthesis R-HSA-209968 7.175299e-01 0.144 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 7.175299e-01 0.144 0 0
Signaling by Erythropoietin R-HSA-9006335 7.175299e-01 0.144 0 0
RNA Polymerase II Transcription R-HSA-73857 7.180613e-01 0.144 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 7.182337e-01 0.144 0 0
Mitochondrial protein import R-HSA-1268020 7.185903e-01 0.144 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 7.185903e-01 0.144 0 0
Heme signaling R-HSA-9707616 7.185903e-01 0.144 0 0
Signaling by PDGF R-HSA-186797 7.185903e-01 0.144 0 0
Gastrulation R-HSA-9758941 7.197299e-01 0.143 0 0
Mitochondrial protein degradation R-HSA-9837999 7.242564e-01 0.140 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.275615e-01 0.138 0 0
DAP12 signaling R-HSA-2424491 7.275615e-01 0.138 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.275615e-01 0.138 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 7.275615e-01 0.138 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 7.275615e-01 0.138 0 0
Interleukin-37 signaling R-HSA-9008059 7.275615e-01 0.138 0 0
Insulin receptor signalling cascade R-HSA-74751 7.328775e-01 0.135 0 0
IGF1R signaling cascade R-HSA-2428924 7.328775e-01 0.135 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.372375e-01 0.132 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 7.397871e-01 0.131 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 7.397871e-01 0.131 0 0
G1/S Transition R-HSA-69206 7.433233e-01 0.129 0 0
G0 and Early G1 R-HSA-1538133 7.465704e-01 0.127 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 7.465704e-01 0.127 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 7.465704e-01 0.127 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.465704e-01 0.127 0 0
DNA strand elongation R-HSA-69190 7.465704e-01 0.127 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 7.473447e-01 0.126 0 0
Signaling by FGFR R-HSA-190236 7.528695e-01 0.123 0 0
G2/M Checkpoints R-HSA-69481 7.531245e-01 0.123 0 0
Nuclear RNA decay R-HSA-9930044 7.555723e-01 0.122 0 0
Activation of ATR in response to replication stress R-HSA-176187 7.555723e-01 0.122 0 0
Cardiogenesis R-HSA-9733709 7.555723e-01 0.122 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 7.555723e-01 0.122 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 7.555723e-01 0.122 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 7.555723e-01 0.122 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 7.555723e-01 0.122 0 0
HATs acetylate histones R-HSA-3214847 7.582968e-01 0.120 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 7.642551e-01 0.117 0 0
Acyl chain remodelling of PC R-HSA-1482788 7.642551e-01 0.117 0 0
Effects of PIP2 hydrolysis R-HSA-114508 7.642551e-01 0.117 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 7.642551e-01 0.117 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 7.720810e-01 0.112 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 7.720810e-01 0.112 0 0
Calnexin/calreticulin cycle R-HSA-901042 7.726299e-01 0.112 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 7.726299e-01 0.112 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 7.726299e-01 0.112 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 7.726299e-01 0.112 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 7.726299e-01 0.112 0 0
Signal amplification R-HSA-392518 7.726299e-01 0.112 0 0
PI Metabolism R-HSA-1483255 7.740027e-01 0.111 0 0
Metabolism of porphyrins R-HSA-189445 7.781046e-01 0.109 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 7.781046e-01 0.109 0 0
Innate Immune System R-HSA-168249 7.798265e-01 0.108 0 0
Acyl chain remodelling of PE R-HSA-1482839 7.807076e-01 0.108 0 0
Oncogene Induced Senescence R-HSA-2559585 7.807076e-01 0.108 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 7.807076e-01 0.108 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 7.807076e-01 0.108 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 7.807076e-01 0.108 0 0
Circadian clock R-HSA-9909396 7.808004e-01 0.107 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 7.839884e-01 0.106 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 7.840021e-01 0.106 0 0
RNA Polymerase III Transcription R-HSA-74158 7.884989e-01 0.103 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 7.884989e-01 0.103 0 0
G1/S-Specific Transcription R-HSA-69205 7.884989e-01 0.103 0 0
Triglyceride catabolism R-HSA-163560 7.884989e-01 0.103 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.889225e-01 0.103 0 0
Switching of origins to a post-replicative state R-HSA-69052 7.897347e-01 0.103 0 0
Ca2+ pathway R-HSA-4086398 7.897347e-01 0.103 0 0
Nucleotide Excision Repair R-HSA-5696398 7.936332e-01 0.100 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 7.960138e-01 0.099 0 0
Degradation of DVL R-HSA-4641258 7.960138e-01 0.099 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 7.960138e-01 0.099 0 0
NCAM1 interactions R-HSA-419037 7.960138e-01 0.099 0 0
Metabolism of folate and pterines R-HSA-196757 7.960138e-01 0.099 0 0
Platelet homeostasis R-HSA-418346 7.983132e-01 0.098 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 8.008245e-01 0.096 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.019373e-01 0.096 0 0
G alpha (q) signalling events R-HSA-416476 8.036003e-01 0.095 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.059607e-01 0.094 0 0
Interleukin-12 signaling R-HSA-9020591 8.061726e-01 0.094 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 8.074071e-01 0.093 0 0
Stabilization of p53 R-HSA-69541 8.102534e-01 0.091 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.102534e-01 0.091 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 8.102534e-01 0.091 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 8.102534e-01 0.091 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.115651e-01 0.091 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.150297e-01 0.089 0 0
Signaling by Nuclear Receptors R-HSA-9006931 8.151910e-01 0.089 0 0
TCR signaling R-HSA-202403 8.161532e-01 0.088 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 8.169966e-01 0.088 0 0
Attenuation phase R-HSA-3371568 8.169966e-01 0.088 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.169966e-01 0.088 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.176339e-01 0.087 0 0
Leishmania phagocytosis R-HSA-9664417 8.176339e-01 0.087 0 0
Parasite infection R-HSA-9664407 8.176339e-01 0.087 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 8.214577e-01 0.085 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 8.235005e-01 0.084 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.235005e-01 0.084 0 0
Maturation of spike protein R-HSA-9694548 8.235005e-01 0.084 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.235005e-01 0.084 0 0
Signaling by FGFR2 R-HSA-5654738 8.263075e-01 0.083 0 0
Signaling by MET R-HSA-6806834 8.263075e-01 0.083 0 0
Metabolism of proteins R-HSA-392499 8.280002e-01 0.082 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 8.297737e-01 0.081 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 8.326369e-01 0.080 0 0
FCERI mediated NF-kB activation R-HSA-2871837 8.358025e-01 0.078 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 8.358243e-01 0.078 0 0
Activation of GABAB receptors R-HSA-991365 8.358243e-01 0.078 0 0
GABA B receptor activation R-HSA-977444 8.358243e-01 0.078 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.358243e-01 0.078 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 8.416602e-01 0.075 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 8.416602e-01 0.075 0 0
Signaling by FGFR4 R-HSA-5654743 8.416602e-01 0.075 0 0
Response of Mtb to phagocytosis R-HSA-9637690 8.416602e-01 0.075 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 8.426350e-01 0.074 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 8.441522e-01 0.074 0 0
Proteasome assembly R-HSA-9907900 8.472890e-01 0.072 0 0
DAP12 interactions R-HSA-2172127 8.472890e-01 0.072 0 0
Cyclin D associated events in G1 R-HSA-69231 8.472890e-01 0.072 0 0
G1 Phase R-HSA-69236 8.472890e-01 0.072 0 0
EPHB-mediated forward signaling R-HSA-3928662 8.472890e-01 0.072 0 0
Methylation R-HSA-156581 8.472890e-01 0.072 0 0
Netrin-1 signaling R-HSA-373752 8.472890e-01 0.072 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 8.527180e-01 0.069 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 8.527180e-01 0.069 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 8.527180e-01 0.069 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 8.527180e-01 0.069 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 8.527180e-01 0.069 0 0
Signaling by FGFR3 R-HSA-5654741 8.527180e-01 0.069 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.579543e-01 0.067 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.579543e-01 0.067 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.579543e-01 0.067 0 0
Regulation of TNFR1 signaling R-HSA-5357905 8.579543e-01 0.067 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 8.630048e-01 0.064 0 0
Synthesis of PC R-HSA-1483191 8.630048e-01 0.064 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 8.678760e-01 0.062 0 0
GPER1 signaling R-HSA-9634597 8.678760e-01 0.062 0 0
Gluconeogenesis R-HSA-70263 8.678760e-01 0.062 0 0
NGF-stimulated transcription R-HSA-9031628 8.678760e-01 0.062 0 0
PPARA activates gene expression R-HSA-1989781 8.704880e-01 0.060 0 0
Neurotransmitter release cycle R-HSA-112310 8.723175e-01 0.059 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 8.725743e-01 0.059 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 8.725743e-01 0.059 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.760686e-01 0.057 0 0
Regulation of RAS by GAPs R-HSA-5658442 8.771058e-01 0.057 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 8.772148e-01 0.057 0 0
HIV Infection R-HSA-162906 8.807504e-01 0.055 0 0
Hedgehog ligand biogenesis R-HSA-5358346 8.814764e-01 0.055 0 0
The phototransduction cascade R-HSA-2514856 8.814764e-01 0.055 0 0
Signaling by Insulin receptor R-HSA-74752 8.827623e-01 0.054 0 0
Signaling by TGFB family members R-HSA-9006936 8.840495e-01 0.054 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 8.856918e-01 0.053 0 0
Orc1 removal from chromatin R-HSA-68949 8.856918e-01 0.053 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.856918e-01 0.053 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.892806e-01 0.051 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.897576e-01 0.051 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.897576e-01 0.051 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 8.897576e-01 0.051 0 0
Nucleotide biosynthesis R-HSA-8956320 8.897576e-01 0.051 0 0
Paracetamol ADME R-HSA-9753281 8.974611e-01 0.047 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 8.984304e-01 0.047 0 0
Metabolism of nucleotides R-HSA-15869 8.997808e-01 0.046 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.011089e-01 0.045 0 0
Regulation of insulin secretion R-HSA-422356 9.041338e-01 0.044 0 0
Dectin-2 family R-HSA-5621480 9.046271e-01 0.044 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.080204e-01 0.042 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.080204e-01 0.042 0 0
Peroxisomal protein import R-HSA-9033241 9.112932e-01 0.040 0 0
Triglyceride metabolism R-HSA-8979227 9.112932e-01 0.040 0 0
GABA receptor activation R-HSA-977443 9.144497e-01 0.039 0 0
tRNA Aminoacylation R-HSA-379724 9.144497e-01 0.039 0 0
Metabolism of polyamines R-HSA-351202 9.144497e-01 0.039 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.144497e-01 0.039 0 0
Parasitic Infection Pathways R-HSA-9824443 9.174467e-01 0.037 0 0
Leishmania infection R-HSA-9658195 9.174467e-01 0.037 0 0
Aquaporin-mediated transport R-HSA-445717 9.174941e-01 0.037 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.174941e-01 0.037 0 0
Collagen degradation R-HSA-1442490 9.174941e-01 0.037 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.204303e-01 0.036 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.204303e-01 0.036 0 0
RSV-host interactions R-HSA-9833110 9.218235e-01 0.035 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 9.228878e-01 0.035 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 9.232622e-01 0.035 0 0
Xenobiotics R-HSA-211981 9.259935e-01 0.033 0 0
Ion transport by P-type ATPases R-HSA-936837 9.259935e-01 0.033 0 0
Synthesis of DNA R-HSA-69239 9.284230e-01 0.032 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.305035e-01 0.031 0 0
Translation R-HSA-72766 9.330298e-01 0.030 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.336186e-01 0.030 0 0
Antimicrobial peptides R-HSA-6803157 9.364072e-01 0.029 0 0
Phospholipid metabolism R-HSA-1483257 9.370248e-01 0.028 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.382673e-01 0.028 0 0
MITF-M-dependent gene expression R-HSA-9856651 9.416259e-01 0.026 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.425795e-01 0.026 0 0
Metabolism of cofactors R-HSA-8978934 9.425795e-01 0.026 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 9.446242e-01 0.025 0 0
Purine catabolism R-HSA-74259 9.446242e-01 0.025 0 0
Protein localization R-HSA-9609507 9.460704e-01 0.024 0 0
Aspirin ADME R-HSA-9749641 9.465962e-01 0.024 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.468184e-01 0.024 0 0
Interferon alpha/beta signaling R-HSA-909733 9.468184e-01 0.024 0 0
Signaling by ERBB4 R-HSA-1236394 9.484982e-01 0.023 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.484982e-01 0.023 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.503325e-01 0.022 0 0
Iron uptake and transport R-HSA-917937 9.503325e-01 0.022 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.538077e-01 0.021 0 0
Translation of Structural Proteins R-HSA-9694635 9.538077e-01 0.021 0 0
Interferon gamma signaling R-HSA-877300 9.540314e-01 0.020 0 0
Interleukin-10 signaling R-HSA-6783783 9.554532e-01 0.020 0 0
ABC transporter disorders R-HSA-5619084 9.554532e-01 0.020 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.570402e-01 0.019 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.584078e-01 0.018 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.588811e-01 0.018 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.600468e-01 0.018 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.600468e-01 0.018 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.628434e-01 0.016 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.629747e-01 0.016 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.641675e-01 0.016 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 9.654445e-01 0.015 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.658231e-01 0.015 0 0
GPCR downstream signalling R-HSA-388396 9.664847e-01 0.015 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.678638e-01 0.014 0 0
Pyruvate metabolism R-HSA-70268 9.690093e-01 0.014 0 0
ER-Phagosome pathway R-HSA-1236974 9.711794e-01 0.013 0 0
Disease R-HSA-1643685 9.733089e-01 0.012 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.750751e-01 0.011 0 0
Infectious disease R-HSA-5663205 9.758397e-01 0.011 0 0
FCGR activation R-HSA-2029481 9.759639e-01 0.011 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 9.799553e-01 0.009 0 0
ABC-family proteins mediated transport R-HSA-382556 9.820250e-01 0.008 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.839918e-01 0.007 0 0
Signaling by GPCR R-HSA-372790 9.841235e-01 0.007 0 0
Arachidonate metabolism R-HSA-2142753 9.848884e-01 0.007 0 0
G alpha (i) signalling events R-HSA-418594 9.869851e-01 0.006 0 0
Developmental Cell Lineages R-HSA-9734767 9.915551e-01 0.004 0 0
Drug ADME R-HSA-9748784 9.916679e-01 0.004 0 0
G alpha (s) signalling events R-HSA-418555 9.919691e-01 0.004 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.924652e-01 0.003 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.924652e-01 0.003 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.924888e-01 0.003 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.930160e-01 0.003 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.941326e-01 0.003 0 0
Nucleotide catabolism R-HSA-8956319 9.945868e-01 0.002 0 0
Diseases of glycosylation R-HSA-3781865 9.947024e-01 0.002 0 0
Sensory perception of taste R-HSA-9717189 9.951470e-01 0.002 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.953205e-01 0.002 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.970858e-01 0.001 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.974023e-01 0.001 0 0
Visual phototransduction R-HSA-2187338 9.974811e-01 0.001 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.977421e-01 0.001 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.979009e-01 0.001 0 0
Transport of small molecules R-HSA-382551 9.980489e-01 0.001 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.983670e-01 0.001 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.986094e-01 0.001 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.987856e-01 0.001 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.988163e-01 0.001 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.990589e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.990912e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.994150e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 9.994551e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.995205e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.996620e-01 0.000 0 0
Biological oxidations R-HSA-211859 9.997186e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 9.999303e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999605e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999617e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.999883e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999964e-01 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cellular responses to stress R-HSA-2262752 7.771561e-16 15.109 1 0
Attenuation phase R-HSA-3371568 8.770762e-15 14.057 0 0
Cellular responses to stimuli R-HSA-8953897 1.731948e-14 13.761 1 0
HSF1-dependent transactivation R-HSA-3371571 1.453282e-13 12.838 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 5.496714e-13 12.260 0 0
Cellular response to heat stress R-HSA-3371556 6.546985e-13 12.184 0 0
HSF1 activation R-HSA-3371511 7.605361e-12 11.119 0 0
Cell Cycle R-HSA-1640170 1.049105e-11 10.979 0 0
Cytokine Signaling in Immune system R-HSA-1280215 5.621392e-11 10.250 0 0
G2/M Transition R-HSA-69275 3.884720e-10 9.411 0 0
Mitotic G2-G2/M phases R-HSA-453274 5.105635e-10 9.292 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 4.774507e-10 9.321 0 0
Cell Cycle, Mitotic R-HSA-69278 8.044310e-10 9.095 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.054939e-09 8.977 0 0
Regulation of CDH1 Function R-HSA-9764561 1.558765e-09 8.807 0 0
Axon guidance R-HSA-422475 2.000937e-09 8.699 0 0
Nervous system development R-HSA-9675108 2.549821e-09 8.593 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.397609e-08 7.855 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.884200e-08 7.725 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.927982e-08 7.533 0 0
Programmed Cell Death R-HSA-5357801 4.508717e-08 7.346 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 5.196686e-08 7.284 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 7.437040e-08 7.129 0 0
Signaling by VEGF R-HSA-194138 9.923500e-08 7.003 0 0
Cell-Cell communication R-HSA-1500931 1.220059e-07 6.914 0 0
G2/M Checkpoints R-HSA-69481 1.316558e-07 6.881 0 0
Cell Cycle Checkpoints R-HSA-69620 1.778870e-07 6.750 0 0
Signaling by Interleukins R-HSA-449147 1.800803e-07 6.745 0 0
Apoptosis R-HSA-109581 1.706160e-07 6.768 0 0
M Phase R-HSA-68886 3.427116e-07 6.465 0 0
Aggrephagy R-HSA-9646399 3.799183e-07 6.420 0 0
Cell junction organization R-HSA-446728 4.250667e-07 6.372 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 4.550980e-07 6.342 0 0
Recycling pathway of L1 R-HSA-437239 5.261604e-07 6.279 0 0
Signal Transduction R-HSA-162582 9.910232e-07 6.004 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.052917e-06 5.978 0 0
Interferon Signaling R-HSA-913531 1.809830e-06 5.742 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.907074e-06 5.720 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.907074e-06 5.720 0 0
Apoptotic execution phase R-HSA-75153 2.059972e-06 5.686 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 3.336959e-06 5.477 0 0
Macroautophagy R-HSA-1632852 3.137219e-06 5.503 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 3.668362e-06 5.436 0 0
PKR-mediated signaling R-HSA-9833482 3.742531e-06 5.427 0 0
Immune System R-HSA-168256 3.637879e-06 5.439 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.978258e-06 5.400 0 0
Cellular Senescence R-HSA-2559583 3.876595e-06 5.412 1 0
Selective autophagy R-HSA-9663891 4.123566e-06 5.385 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 4.622297e-06 5.335 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.737967e-06 5.324 0 0
Autophagy R-HSA-9612973 6.256075e-06 5.204 0 0
ISG15 antiviral mechanism R-HSA-1169408 6.289783e-06 5.201 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 6.682464e-06 5.175 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 6.682464e-06 5.175 0 0
SARS-CoV-1-host interactions R-HSA-9692914 6.706037e-06 5.174 0 0
Adherens junctions interactions R-HSA-418990 8.232811e-06 5.084 0 0
Signaling by RAS mutants R-HSA-6802949 9.596934e-06 5.018 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 9.596934e-06 5.018 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 9.596934e-06 5.018 0 0
Signaling downstream of RAS mutants R-HSA-9649948 9.596934e-06 5.018 0 0
Cell-cell junction organization R-HSA-421270 8.970281e-06 5.047 0 0
L1CAM interactions R-HSA-373760 9.571361e-06 5.019 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.167006e-05 4.933 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 1.259902e-05 4.900 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.275315e-05 4.894 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.275315e-05 4.894 0 0
Post NMDA receptor activation events R-HSA-438064 1.244679e-05 4.905 0 0
Mitotic Prometaphase R-HSA-68877 1.310527e-05 4.883 0 0
Separation of Sister Chromatids R-HSA-2467813 1.395191e-05 4.855 0 0
Membrane Trafficking R-HSA-199991 1.513262e-05 4.820 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.519662e-05 4.818 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.691318e-05 4.772 0 0
Mitotic Anaphase R-HSA-68882 1.692984e-05 4.771 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.697235e-05 4.770 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.706623e-05 4.768 0 0
Degradation of CDH1 R-HSA-9766229 1.731397e-05 4.762 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.838216e-05 4.736 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.897918e-05 4.722 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.897918e-05 4.722 0 0
AURKA Activation by TPX2 R-HSA-8854518 2.090580e-05 4.680 0 0
Centrosome maturation R-HSA-380287 2.296625e-05 4.639 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 3.184313e-05 4.497 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.538336e-05 4.451 1 1
PCP/CE pathway R-HSA-4086400 3.549591e-05 4.450 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.845032e-05 4.415 0 0
Neutrophil degranulation R-HSA-6798695 3.880097e-05 4.411 0 0
Regulation of PTEN localization R-HSA-8948747 4.314730e-05 4.365 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.553185e-05 4.342 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 5.715377e-05 4.243 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 5.715377e-05 4.243 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 5.643805e-05 4.248 0 0
Dual Incision in GG-NER R-HSA-5696400 6.237550e-05 4.205 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 7.259256e-05 4.139 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 6.945369e-05 4.158 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 7.259256e-05 4.139 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 7.099587e-05 4.149 0 0
Signaling by ALK in cancer R-HSA-9700206 7.099587e-05 4.149 0 0
Uptake and function of anthrax toxins R-HSA-5210891 8.095470e-05 4.092 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 8.095470e-05 4.092 0 0
G1/S Transition R-HSA-69206 8.294556e-05 4.081 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 8.418558e-05 4.075 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 8.852381e-05 4.053 0 0
Hedgehog 'off' state R-HSA-5610787 8.436939e-05 4.074 0 0
Orc1 removal from chromatin R-HSA-68949 1.180540e-04 3.928 0 0
Degradation of DVL R-HSA-4641258 1.151387e-04 3.939 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 1.162070e-04 3.935 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.095416e-04 3.960 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.058548e-04 3.975 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.054312e-04 3.977 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.095416e-04 3.960 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.201801e-04 3.920 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.255450e-04 3.901 0 0
Neurodegenerative Diseases R-HSA-8863678 1.255450e-04 3.901 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.255450e-04 3.901 0 0
MAP kinase activation R-HSA-450294 1.290793e-04 3.889 0 0
MAPK family signaling cascades R-HSA-5683057 1.246236e-04 3.904 0 0
Translesion Synthesis by POLH R-HSA-110320 1.460026e-04 3.836 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 1.429795e-04 3.845 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.342938e-04 3.872 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.429795e-04 3.845 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.429795e-04 3.845 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 1.493815e-04 3.826 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.537842e-04 3.813 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.537842e-04 3.813 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.548453e-04 3.810 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.598232e-04 3.796 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.679031e-04 3.775 0 0
Formation of definitive endoderm R-HSA-9823730 1.919213e-04 3.717 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.923038e-04 3.716 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.002354e-04 3.698 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.877358e-04 3.726 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.901949e-04 3.721 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.821581e-04 3.740 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.002686e-04 3.698 0 0
Synthesis of DNA R-HSA-69239 2.019556e-04 3.695 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.068092e-04 3.684 0 0
p38MAPK events R-HSA-171007 2.068092e-04 3.684 0 0
Translesion synthesis by REV1 R-HSA-110312 2.068092e-04 3.684 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.068092e-04 3.684 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.068092e-04 3.684 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.320903e-04 3.634 0 0
Signaling by EGFR R-HSA-177929 2.191380e-04 3.659 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.191380e-04 3.659 0 0
Platelet activation, signaling and aggregation R-HSA-76002 2.178454e-04 3.662 0 0
Cellular response to hypoxia R-HSA-1234174 2.276988e-04 3.643 0 0
SARS-CoV Infections R-HSA-9679506 2.153419e-04 3.667 0 0
FLT3 Signaling R-HSA-9607240 2.410988e-04 3.618 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.432447e-04 3.614 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 2.490812e-04 3.604 0 0
Translesion synthesis by POLI R-HSA-5656121 2.810423e-04 3.551 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 2.814583e-04 3.551 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.520060e-04 3.599 0 0
Gap junction trafficking and regulation R-HSA-157858 2.749488e-04 3.561 0 0
Metabolism of RNA R-HSA-8953854 2.577064e-04 3.589 0 0
NOD1/2 Signaling Pathway R-HSA-168638 2.814583e-04 3.551 0 0
Negative regulation of FLT3 R-HSA-9706369 2.810423e-04 3.551 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.583620e-04 3.588 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.864531e-04 3.543 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 3.194729e-04 3.496 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 3.194729e-04 3.496 0 0
Regulation of RAS by GAPs R-HSA-5658442 3.207112e-04 3.494 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 3.393131e-04 3.469 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.526368e-04 3.453 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 3.597480e-04 3.444 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 3.727675e-04 3.429 0 0
Translesion synthesis by POLK R-HSA-5655862 3.753066e-04 3.426 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 3.989478e-04 3.399 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 4.317931e-04 3.365 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 4.678143e-04 3.330 0 0
Interleukin-17 signaling R-HSA-448424 4.367187e-04 3.360 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 4.317931e-04 3.365 0 0
SARS-CoV-2-host interactions R-HSA-9705683 4.613985e-04 3.336 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 4.849999e-04 3.314 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.985134e-04 3.302 0 0
RAF/MAP kinase cascade R-HSA-5673001 5.277913e-04 3.278 0 0
Signaling by FGFR3 R-HSA-5654741 5.463570e-04 3.263 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 5.574618e-04 3.254 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 5.696340e-04 3.244 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 5.696340e-04 3.244 0 0
Semaphorin interactions R-HSA-373755 5.748756e-04 3.240 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.748756e-04 3.240 0 0
Co-inhibition by PD-1 R-HSA-389948 6.570211e-04 3.182 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 6.581965e-04 3.182 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 6.600818e-04 3.180 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 6.600818e-04 3.180 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 6.791379e-04 3.168 0 0
RAS processing R-HSA-9648002 6.791379e-04 3.168 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 6.859251e-04 3.164 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 7.391675e-04 3.131 0 0
Ribosome-associated quality control R-HSA-9948299 8.052504e-04 3.094 0 0
EPH-Ephrin signaling R-HSA-2682334 7.455098e-04 3.128 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 7.350906e-04 3.134 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 7.528718e-04 3.123 0 0
Interleukin-6 signaling R-HSA-1059683 7.265833e-04 3.139 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.003710e-04 3.097 0 0
TCR signaling R-HSA-202403 7.240406e-04 3.140 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 7.979259e-04 3.098 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 7.265833e-04 3.139 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 7.979259e-04 3.098 0 0
Cilium Assembly R-HSA-5617833 7.208921e-04 3.142 0 0
G2/M DNA damage checkpoint R-HSA-69473 7.054467e-04 3.152 0 0
Organelle biogenesis and maintenance R-HSA-1852241 7.621763e-04 3.118 0 0
Developmental Biology R-HSA-1266738 7.231778e-04 3.141 0 0
Signaling by Hedgehog R-HSA-5358351 8.052504e-04 3.094 0 0
Signaling by ROBO receptors R-HSA-376176 8.003710e-04 3.097 0 0
S Phase R-HSA-69242 8.118857e-04 3.091 0 0
Regulation of signaling by CBL R-HSA-912631 8.172111e-04 3.088 0 0
Oncogenic MAPK signaling R-HSA-6802957 8.179947e-04 3.087 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 8.179947e-04 3.087 0 0
Activation of ATR in response to replication stress R-HSA-176187 8.221644e-04 3.085 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 8.677805e-04 3.062 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 8.677805e-04 3.062 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.055792e-04 3.043 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.086896e-04 3.042 0 0
MITF-M-dependent gene expression R-HSA-9856651 9.442018e-04 3.025 0 0
Striated Muscle Contraction R-HSA-390522 9.789058e-04 3.009 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.789058e-04 3.009 0 0
Viral Infection Pathways R-HSA-9824446 1.003253e-03 2.999 0 0
MAP2K and MAPK activation R-HSA-5674135 1.086921e-03 2.964 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 1.086921e-03 2.964 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 1.086921e-03 2.964 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.094715e-03 2.961 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.105103e-03 2.957 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.159035e-03 2.936 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 1.159035e-03 2.936 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.377214e-03 2.861 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 1.377214e-03 2.861 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.454003e-03 2.837 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.454003e-03 2.837 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.276631e-03 2.894 0 0
Signaling by ERBB2 R-HSA-1227986 1.253011e-03 2.902 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.283861e-03 2.891 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 1.365035e-03 2.865 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 1.215022e-03 2.915 0 0
Signalling to RAS R-HSA-167044 1.289598e-03 2.890 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.395349e-03 2.855 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.362704e-03 2.866 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.278457e-03 2.893 0 0
Regulation of Apoptosis R-HSA-169911 1.365035e-03 2.865 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.278457e-03 2.893 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.232438e-03 2.909 0 0
Kinesins R-HSA-983189 1.253011e-03 2.902 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.278457e-03 2.893 0 0
Signaling by SCF-KIT R-HSA-1433557 1.456305e-03 2.837 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 1.463211e-03 2.835 0 0
Hedgehog 'on' state R-HSA-5632684 1.485739e-03 2.828 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.493100e-03 2.826 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.533995e-03 2.814 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.533995e-03 2.814 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.584746e-03 2.800 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 1.599528e-03 2.796 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.601697e-03 2.795 0 0
Maturation of protein E R-HSA-9683683 1.625027e-03 2.789 0 0
Maturation of protein E R-HSA-9694493 1.625027e-03 2.789 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.656554e-03 2.781 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 1.662578e-03 2.779 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.662578e-03 2.779 0 0
Termination of translesion DNA synthesis R-HSA-5656169 1.669252e-03 2.777 0 0
Late endosomal microautophagy R-HSA-9615710 1.669252e-03 2.777 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.671029e-03 2.777 0 0
Gap junction trafficking R-HSA-190828 1.675960e-03 2.776 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.711258e-03 2.767 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.813459e-03 2.741 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.843306e-03 2.734 0 0
Degradation of AXIN R-HSA-4641257 1.865275e-03 2.729 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 1.865275e-03 2.729 0 0
Translation initiation complex formation R-HSA-72649 1.883593e-03 2.725 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.883593e-03 2.725 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.898030e-03 2.722 0 0
Regulation of TP53 Activity R-HSA-5633007 1.921024e-03 2.716 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.989543e-03 2.701 0 0
Signaling by FGFR in disease R-HSA-1226099 2.047104e-03 2.689 0 0
Signaling by NOTCH4 R-HSA-9013694 2.047104e-03 2.689 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 2.127957e-03 2.672 0 0
Assembly of the pre-replicative complex R-HSA-68867 2.179626e-03 2.662 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 2.195704e-03 2.658 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.236673e-03 2.650 0 0
Vesicle-mediated transport R-HSA-5653656 2.284657e-03 2.641 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.329658e-03 2.633 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.481054e-03 2.605 0 0
Stabilization of p53 R-HSA-69541 2.502242e-03 2.602 0 0
UCH proteinases R-HSA-5689603 2.510497e-03 2.600 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 2.549959e-03 2.593 0 0
NF-kB is activated and signals survival R-HSA-209560 2.549959e-03 2.593 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 2.549959e-03 2.593 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.644079e-03 2.578 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.644079e-03 2.578 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 3.281117e-03 2.484 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 3.281117e-03 2.484 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.693906e-03 2.570 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.019253e-03 2.520 0 0
DNA Damage Bypass R-HSA-73893 3.210793e-03 2.493 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.879629e-03 2.541 0 0
Diseases of programmed cell death R-HSA-9645723 3.250749e-03 2.488 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 2.702860e-03 2.568 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.918958e-03 2.535 0 0
Glycogen metabolism R-HSA-8982491 2.879629e-03 2.541 0 0
Interleukin-12 family signaling R-HSA-447115 2.970054e-03 2.527 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 3.210793e-03 2.493 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 3.210793e-03 2.493 0 0
Infectious disease R-HSA-5663205 2.884084e-03 2.540 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.293418e-03 2.482 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 3.300595e-03 2.481 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 3.300595e-03 2.481 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 3.300595e-03 2.481 0 0
VLDLR internalisation and degradation R-HSA-8866427 3.350634e-03 2.475 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.663186e-03 2.436 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.663186e-03 2.436 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.663186e-03 2.436 0 0
Degradation of CRY and PER proteins R-HSA-9932298 3.768510e-03 2.424 0 0
Negative regulation of MAPK pathway R-HSA-5675221 3.768510e-03 2.424 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.768510e-03 2.424 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.768510e-03 2.424 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 3.776225e-03 2.423 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 3.939106e-03 2.405 0 0
Myogenesis R-HSA-525793 4.042256e-03 2.393 0 0
Processing of DNA double-strand break ends R-HSA-5693607 4.053446e-03 2.392 0 0
Signaling by TGFB family members R-HSA-9006936 4.058111e-03 2.392 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 4.188754e-03 2.378 0 0
Ca-dependent events R-HSA-111996 4.286841e-03 2.368 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 4.286841e-03 2.368 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.289578e-03 2.368 0 0
Gap junction assembly R-HSA-190861 4.319571e-03 2.365 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.327591e-03 2.364 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.327591e-03 2.364 0 0
PTEN Regulation R-HSA-6807070 4.380360e-03 2.358 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 4.568249e-03 2.340 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 4.761536e-03 2.322 0 0
Signaling by FGFR4 R-HSA-5654743 4.859148e-03 2.313 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 4.859148e-03 2.313 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 4.970925e-03 2.304 0 0
Protein folding R-HSA-391251 4.998093e-03 2.301 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 5.031615e-03 2.298 0 0
Modulation by Mtb of host immune system R-HSA-9637628 5.031615e-03 2.298 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 5.411288e-03 2.267 0 0
DNA Replication R-HSA-69306 5.431182e-03 2.265 0 0
DNA Double-Strand Break Repair R-HSA-5693532 5.431182e-03 2.265 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.468904e-03 2.262 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 5.468904e-03 2.262 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.468904e-03 2.262 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 5.523038e-03 2.258 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 6.921019e-03 2.160 0 0
Diseases of Telomere Maintenance R-HSA-9673013 6.921019e-03 2.160 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 6.921019e-03 2.160 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 6.921019e-03 2.160 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 6.921019e-03 2.160 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 7.011375e-03 2.154 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 7.037776e-03 2.153 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 6.912545e-03 2.160 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 6.366762e-03 2.196 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 5.887396e-03 2.230 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 6.496452e-03 2.187 0 0
Nucleotide Excision Repair R-HSA-5696398 6.833721e-03 2.165 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 6.496452e-03 2.187 0 0
Chaperonin-mediated protein folding R-HSA-390466 7.414150e-03 2.130 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 6.794659e-03 2.168 0 0
GP1b-IX-V activation signalling R-HSA-430116 6.794659e-03 2.168 0 0
CaM pathway R-HSA-111997 5.694892e-03 2.245 0 0
Calmodulin induced events R-HSA-111933 5.694892e-03 2.245 0 0
DAG and IP3 signaling R-HSA-1489509 6.180317e-03 2.209 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.821297e-03 2.166 0 0
COPI-mediated anterograde transport R-HSA-6807878 7.434914e-03 2.129 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 6.484151e-03 2.188 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 7.434914e-03 2.129 0 0
Chromatin organization R-HSA-4839726 5.639200e-03 2.249 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 6.705590e-03 2.174 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 7.308590e-03 2.136 0 0
Muscle contraction R-HSA-397014 5.695135e-03 2.244 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 6.180317e-03 2.209 0 0
p75NTR signals via NF-kB R-HSA-193639 6.821297e-03 2.166 0 0
FLT3 signaling in disease R-HSA-9682385 5.694892e-03 2.245 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 6.180317e-03 2.209 0 0
Influenza Infection R-HSA-168255 6.526707e-03 2.185 0 0
Interleukin-12 signaling R-HSA-9020591 6.642661e-03 2.178 0 0
Activation of BH3-only proteins R-HSA-114452 7.501476e-03 2.125 0 0
Cellular response to chemical stress R-HSA-9711123 7.559479e-03 2.122 0 0
G-protein mediated events R-HSA-112040 7.594120e-03 2.120 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 7.761915e-03 2.110 0 0
Peptide chain elongation R-HSA-156902 8.035541e-03 2.095 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.180006e-03 2.087 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 8.291572e-03 2.081 0 0
Regulated Necrosis R-HSA-5218859 8.326896e-03 2.080 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 8.391659e-03 2.076 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 8.477895e-03 2.072 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 8.477895e-03 2.072 0 0
Dual incision in TC-NER R-HSA-6782135 8.607505e-03 2.065 0 0
EGFR downregulation R-HSA-182971 8.632167e-03 2.064 0 0
Budding and maturation of HIV virion R-HSA-162588 8.632167e-03 2.064 0 0
Homology Directed Repair R-HSA-5693538 8.807373e-03 2.055 0 0
Folding of actin by CCT/TriC R-HSA-390450 8.924213e-03 2.049 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 8.924213e-03 2.049 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 8.924213e-03 2.049 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 8.924213e-03 2.049 0 0
Josephin domain DUBs R-HSA-5689877 8.924213e-03 2.049 0 0
Pexophagy R-HSA-9664873 8.924213e-03 2.049 0 0
Chromatin modifying enzymes R-HSA-3247509 9.077857e-03 2.042 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 9.090855e-03 2.041 0 0
Downstream TCR signaling R-HSA-202424 9.400979e-03 2.027 0 0
G0 and Early G1 R-HSA-1538133 9.883208e-03 2.005 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 9.955922e-03 2.002 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.014208e-02 1.994 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 1.019604e-02 1.992 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.019604e-02 1.992 0 0
Innate Immune System R-HSA-168249 1.025255e-02 1.989 0 0
ESR-mediated signaling R-HSA-8939211 1.041043e-02 1.983 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.057980e-02 1.976 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.073363e-02 1.969 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.126151e-02 1.948 0 0
Interleukin-6 family signaling R-HSA-6783589 1.134087e-02 1.945 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.144750e-02 1.941 0 0
Hemostasis R-HSA-109582 1.150434e-02 1.939 0 0
Death Receptor Signaling R-HSA-73887 1.153381e-02 1.938 0 0
Hedgehog ligand biogenesis R-HSA-5358346 1.182943e-02 1.927 0 0
MHC class II antigen presentation R-HSA-2132295 1.213813e-02 1.916 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.218432e-02 1.914 0 0
Glycogen storage diseases R-HSA-3229121 1.224966e-02 1.912 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.270054e-02 1.896 0 0
mRNA 3'-end processing R-HSA-72187 1.305736e-02 1.884 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.312961e-02 1.882 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.312961e-02 1.882 0 0
Long-term potentiation R-HSA-9620244 1.312961e-02 1.882 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.363853e-02 1.865 0 0
Phosphorylation of Emi1 R-HSA-176417 1.363853e-02 1.865 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.363853e-02 1.865 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.370368e-02 1.863 0 0
Signaling by PTK6 R-HSA-8848021 1.370368e-02 1.863 0 0
Smooth Muscle Contraction R-HSA-445355 1.437745e-02 1.842 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.438847e-02 1.842 0 0
RAF activation R-HSA-5673000 1.442699e-02 1.841 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.456680e-02 1.837 0 0
Manipulation of host energy metabolism R-HSA-9636667 1.495782e-02 1.825 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.509905e-02 1.821 0 0
HCMV Early Events R-HSA-9609690 1.550316e-02 1.810 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.565212e-02 1.805 0 0
Signalling to ERKs R-HSA-187687 1.622733e-02 1.790 0 0
Cyclin D associated events in G1 R-HSA-69231 1.630933e-02 1.788 0 0
G1 Phase R-HSA-69236 1.630933e-02 1.788 0 0
Platelet degranulation R-HSA-114608 1.638540e-02 1.786 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.716070e-02 1.765 0 0
Signaling by FGFR3 in disease R-HSA-5655332 1.728176e-02 1.762 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 1.728176e-02 1.762 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.728176e-02 1.762 0 0
Signaling by NOTCH3 R-HSA-9012852 1.730927e-02 1.762 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.776765e-02 1.750 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.776765e-02 1.750 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 1.776765e-02 1.750 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 1.776765e-02 1.750 0 0
IRAK1 recruits IKK complex R-HSA-937039 1.776765e-02 1.750 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 1.776765e-02 1.750 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.776765e-02 1.750 0 0
Potential therapeutics for SARS R-HSA-9679191 1.793974e-02 1.746 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.818119e-02 1.740 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 1.857176e-02 1.731 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.436794e-02 1.613 0 0
SOS-mediated signalling R-HSA-112412 2.436794e-02 1.613 0 0
Disinhibition of SNARE formation R-HSA-114516 2.436794e-02 1.613 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 2.322591e-02 1.634 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.322591e-02 1.634 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.671769e-02 1.573 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.671769e-02 1.573 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 2.225699e-02 1.653 0 0
Activation of the pre-replicative complex R-HSA-68962 2.507265e-02 1.601 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.988995e-02 1.701 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 2.187553e-02 1.660 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.892847e-02 1.723 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 2.278654e-02 1.642 0 0
Cellular response to starvation R-HSA-9711097 2.671966e-02 1.573 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.425041e-02 1.615 0 0
Mitotic Prophase R-HSA-68875 2.068884e-02 1.684 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.318914e-02 1.635 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.199677e-02 1.658 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 2.590541e-02 1.587 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.507265e-02 1.601 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 2.160209e-02 1.666 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 2.811620e-02 1.551 0 0
Regulation of KIT signaling R-HSA-1433559 2.590541e-02 1.587 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 2.671966e-02 1.573 0 0
Signaling by WNT R-HSA-195721 2.477319e-02 1.606 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 2.590541e-02 1.587 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.782291e-02 1.556 0 0
Negative regulation of MET activity R-HSA-6807004 2.004344e-02 1.698 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 2.671769e-02 1.573 0 0
Intraflagellar transport R-HSA-5620924 2.399714e-02 1.620 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 2.257339e-02 1.646 0 0
Transmission across Chemical Synapses R-HSA-112315 2.318914e-02 1.635 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.225699e-02 1.653 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 1.952247e-02 1.709 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 2.811620e-02 1.551 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 1.952247e-02 1.709 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 2.317886e-02 1.635 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 2.436794e-02 1.613 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 2.317886e-02 1.635 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 2.613335e-02 1.583 0 0
Signaling by MET R-HSA-6806834 2.202250e-02 1.657 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 2.225699e-02 1.653 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 2.322591e-02 1.634 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.502302e-02 1.602 0 0
Signaling by FGFR1 R-HSA-5654736 1.892847e-02 1.723 0 0
Glycogen synthesis R-HSA-3322077 2.004344e-02 1.698 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.226608e-02 1.652 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.918886e-02 1.717 0 0
PLC beta mediated events R-HSA-112043 2.869936e-02 1.542 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.869936e-02 1.542 0 0
HCMV Infection R-HSA-9609646 3.018618e-02 1.520 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 3.045523e-02 1.516 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.052708e-02 1.515 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 3.052708e-02 1.515 0 0
mTORC1-mediated signalling R-HSA-166208 3.052708e-02 1.515 0 0
Signaling by KIT in disease R-HSA-9669938 3.052708e-02 1.515 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 3.052708e-02 1.515 0 0
Erythropoietin activates RAS R-HSA-9027284 3.068783e-02 1.513 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 3.068783e-02 1.513 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 3.068783e-02 1.513 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 3.068783e-02 1.513 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 3.068783e-02 1.513 0 0
Interferon alpha/beta signaling R-HSA-909733 3.093008e-02 1.510 0 0
Ub-specific processing proteases R-HSA-5689880 3.098891e-02 1.509 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 3.101173e-02 1.508 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.102818e-02 1.508 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.139373e-02 1.503 0 0
Gene expression (Transcription) R-HSA-74160 3.145041e-02 1.502 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 3.237782e-02 1.490 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 3.239057e-02 1.490 0 0
Signaling by ERBB4 R-HSA-1236394 3.240673e-02 1.489 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.310546e-02 1.480 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.310546e-02 1.480 0 0
Eukaryotic Translation Termination R-HSA-72764 3.329468e-02 1.478 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 3.392420e-02 1.469 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 3.466104e-02 1.460 0 0
Syndecan interactions R-HSA-3000170 3.466104e-02 1.460 0 0
Protein ubiquitination R-HSA-8852135 3.471432e-02 1.459 0 0
Iron uptake and transport R-HSA-917937 3.471432e-02 1.459 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.491070e-02 1.457 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 3.491070e-02 1.457 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.491070e-02 1.457 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 3.502445e-02 1.456 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 3.595624e-02 1.444 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 3.595624e-02 1.444 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 3.595624e-02 1.444 0 0
Regulation of BACH1 activity R-HSA-9708530 3.595624e-02 1.444 0 0
Deubiquitination R-HSA-5688426 3.616892e-02 1.442 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.662848e-02 1.436 0 0
MTOR signalling R-HSA-165159 3.662848e-02 1.436 0 0
MET interacts with TNS proteins R-HSA-8875513 3.835953e-02 1.416 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 3.854325e-02 1.414 0 0
Lipophagy R-HSA-9613354 3.854325e-02 1.414 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.912514e-02 1.408 0 0
Deadenylation of mRNA R-HSA-429947 3.912514e-02 1.408 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.912514e-02 1.408 0 0
mRNA Splicing R-HSA-72172 3.950827e-02 1.403 0 0
Signaling by FGFR R-HSA-190236 3.967883e-02 1.401 0 0
Response of Mtb to phagocytosis R-HSA-9637690 4.000301e-02 1.398 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 4.001316e-02 1.398 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 4.154249e-02 1.382 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 4.171439e-02 1.380 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 4.171439e-02 1.380 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 4.171439e-02 1.380 0 0
G alpha (12/13) signalling events R-HSA-416482 4.231838e-02 1.373 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 4.268133e-02 1.370 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 4.268133e-02 1.370 0 0
Mitophagy R-HSA-5205647 4.268133e-02 1.370 0 0
mRNA Splicing - Major Pathway R-HSA-72163 4.309512e-02 1.366 0 0
Netrin-1 signaling R-HSA-373752 4.357402e-02 1.361 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 4.357402e-02 1.361 0 0
ABC-family proteins mediated transport R-HSA-382556 4.438398e-02 1.353 0 0
DNA Double Strand Break Response R-HSA-5693606 4.452499e-02 1.351 0 0
NRAGE signals death through JNK R-HSA-193648 4.632304e-02 1.334 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 4.632304e-02 1.334 0 0
Interleukin-1 signaling R-HSA-9020702 4.687568e-02 1.329 0 0
Selenocysteine synthesis R-HSA-2408557 4.687568e-02 1.329 0 0
Regulation of CDH11 function R-HSA-9762292 4.689520e-02 1.329 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 4.694244e-02 1.328 0 0
Oncogene Induced Senescence R-HSA-2559585 4.694244e-02 1.328 0 0
TCF dependent signaling in response to WNT R-HSA-201681 4.702943e-02 1.328 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 4.796298e-02 1.319 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 4.796298e-02 1.319 0 0
Signaling by Hippo R-HSA-2028269 4.796298e-02 1.319 0 0
Signaling by FGFR2 R-HSA-5654738 4.797561e-02 1.319 0 0
Host Interactions of HIV factors R-HSA-162909 4.903315e-02 1.310 0 0
Metalloprotease DUBs R-HSA-5689901 4.905945e-02 1.309 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.905945e-02 1.309 0 0
Suppression of phagosomal maturation R-HSA-9637687 4.905945e-02 1.309 0 0
Adaptive Immune System R-HSA-1280218 4.985132e-02 1.302 0 0
Regulation of TNFR1 signaling R-HSA-5357905 5.131660e-02 1.290 0 0
G1/S-Specific Transcription R-HSA-69205 5.145784e-02 1.289 0 0
Viral mRNA Translation R-HSA-192823 5.214397e-02 1.283 0 0
Regulation of gap junction activity R-HSA-191650 5.309196e-02 1.275 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 5.309196e-02 1.275 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 5.309196e-02 1.275 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 5.309196e-02 1.275 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.309196e-02 1.275 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 5.411947e-02 1.267 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.412800e-02 1.267 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 5.427889e-02 1.265 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.453411e-02 1.263 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 5.453411e-02 1.263 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 5.469988e-02 1.262 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 5.469988e-02 1.262 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 5.469988e-02 1.262 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 5.469988e-02 1.262 0 0
Opioid Signalling R-HSA-111885 5.492295e-02 1.260 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 5.605886e-02 1.251 0 0
PECAM1 interactions R-HSA-210990 5.605886e-02 1.251 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.622947e-02 1.250 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 5.734949e-02 1.241 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 5.945410e-02 1.226 0 0
Inflammasomes R-HSA-622312 6.034792e-02 1.219 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 6.034792e-02 1.219 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 6.076149e-02 1.216 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 6.125855e-02 1.213 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.192029e-02 1.208 0 0
The NLRP3 inflammasome R-HSA-844456 6.192029e-02 1.208 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 6.192029e-02 1.208 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 6.600311e-02 1.180 0 0
Signaling by Erythropoietin R-HSA-9006335 6.649989e-02 1.177 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 6.649989e-02 1.177 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.649989e-02 1.177 0 0
Plasma lipoprotein clearance R-HSA-8964043 6.654556e-02 1.177 0 0
Translation R-HSA-72766 6.750090e-02 1.171 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 6.947188e-02 1.158 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 6.947188e-02 1.158 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 6.947188e-02 1.158 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 6.961693e-02 1.157 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 6.961693e-02 1.157 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 6.961693e-02 1.157 0 0
Signal transduction by L1 R-HSA-445144 6.961693e-02 1.157 0 0
Generation of second messenger molecules R-HSA-202433 7.209033e-02 1.142 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 7.298782e-02 1.137 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 7.298782e-02 1.137 0 0
DAP12 signaling R-HSA-2424491 7.298782e-02 1.137 0 0
Leading Strand Synthesis R-HSA-69109 7.669205e-02 1.115 0 0
Polymerase switching R-HSA-69091 7.669205e-02 1.115 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.669205e-02 1.115 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 7.669205e-02 1.115 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 7.669205e-02 1.115 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 7.778027e-02 1.109 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.778027e-02 1.109 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 7.789196e-02 1.109 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 7.906541e-02 1.102 0 0
Trafficking of AMPA receptors R-HSA-399719 7.980834e-02 1.098 0 0
Downstream signal transduction R-HSA-186763 7.980834e-02 1.098 0 0
t(4;14) translocations of FGFR3 R-HSA-2033515 1.679776e-01 0.775 0 0
Signaling by FGFR3 fusions in cancer R-HSA-8853334 1.679776e-01 0.775 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 1.679776e-01 0.775 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 1.679776e-01 0.775 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 1.679776e-01 0.775 0 0
Defective HK1 causes hexokinase deficiency (HK deficiency) R-HSA-5619056 1.679776e-01 0.775 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 1.679776e-01 0.775 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 1.679776e-01 0.775 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 8.725174e-02 1.059 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 1.062075e-01 0.974 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 1.062075e-01 0.974 0 0
IFNG signaling activates MAPKs R-HSA-9732724 1.261370e-01 0.899 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.468575e-01 0.833 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 1.468575e-01 0.833 0 0
Formation of annular gap junctions R-HSA-196025 1.468575e-01 0.833 0 0
FGFR3 mutant receptor activation R-HSA-2033514 8.808599e-02 1.055 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 8.808599e-02 1.055 0 0
Formation of axial mesoderm R-HSA-9796292 8.808599e-02 1.055 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 8.808599e-02 1.055 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 8.808599e-02 1.055 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 8.808599e-02 1.055 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.001424e-01 0.999 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 1.001424e-01 0.999 0 0
SHC1 events in EGFR signaling R-HSA-180336 1.128165e-01 0.948 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 8.639870e-02 1.063 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 1.049453e-01 0.979 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.468066e-01 0.833 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.187078e-01 0.926 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.254845e-01 0.901 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.551041e-01 0.809 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.648522e-01 0.783 0 0
Mitotic Spindle Checkpoint R-HSA-69618 8.444374e-02 1.073 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.291848e-01 0.889 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.284563e-01 0.891 0 0
PERK regulates gene expression R-HSA-381042 1.187078e-01 0.926 0 0
Developmental Cell Lineages R-HSA-9734767 1.567160e-01 0.805 0 0
Killing mechanisms R-HSA-9664420 1.260622e-01 0.899 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 1.260622e-01 0.899 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 9.442824e-02 1.025 0 0
Integrin signaling R-HSA-354192 9.442824e-02 1.025 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 8.725174e-02 1.059 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.808599e-02 1.055 0 0
DCC mediated attractive signaling R-HSA-418885 1.128165e-01 0.948 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 1.540801e-01 0.812 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 1.251303e-01 0.903 0 0
CRMPs in Sema3A signaling R-HSA-399956 1.001424e-01 0.999 0 0
DNA strand elongation R-HSA-69190 8.695699e-02 1.061 0 0
FCERI mediated MAPK activation R-HSA-2871796 8.444500e-02 1.073 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 8.725174e-02 1.059 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 1.398325e-01 0.854 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 1.125431e-01 0.949 0 0
Neddylation R-HSA-8951664 1.107683e-01 0.956 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.412021e-01 0.850 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.216441e-01 0.915 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 1.251303e-01 0.903 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 1.164692e-01 0.934 0 0
Adrenoceptors R-HSA-390696 1.468575e-01 0.833 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.064418e-01 0.973 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 1.354559e-01 0.868 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 1.179637e-01 0.928 0 0
GPVI-mediated activation cascade R-HSA-114604 1.273954e-01 0.895 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.180418e-02 1.037 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 1.153768e-01 0.938 0 0
Inhibition of PKR R-HSA-169131 1.153768e-01 0.938 0 0
Proton/oligopeptide cotransporters R-HSA-427975 8.725174e-02 1.059 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 1.261370e-01 0.899 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 1.468575e-01 0.833 0 0
Activation of RAS in B cells R-HSA-1169092 1.468575e-01 0.833 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.148418e-01 0.940 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.551041e-01 0.809 0 0
Leishmania infection R-HSA-9658195 1.198961e-01 0.921 0 0
Parasitic Infection Pathways R-HSA-9824443 1.198961e-01 0.921 0 0
DNA Repair R-HSA-73894 1.382819e-01 0.859 0 0
IGF1R signaling cascade R-HSA-2428924 1.575358e-01 0.803 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 1.062075e-01 0.974 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 8.639870e-02 1.063 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 1.652407e-01 0.782 0 0
Pyroptosis R-HSA-5620971 1.581539e-01 0.801 0 0
Formation of paraxial mesoderm R-HSA-9793380 1.354559e-01 0.868 0 0
Gastrulation R-HSA-9758941 9.520740e-02 1.021 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 1.254845e-01 0.901 0 0
CHL1 interactions R-HSA-447041 1.261370e-01 0.899 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 9.442824e-02 1.025 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.284563e-01 0.891 0 0
TNF signaling R-HSA-75893 1.023666e-01 0.990 0 0
Estrogen-dependent gene expression R-HSA-9018519 9.347568e-02 1.029 0 0
RNA Polymerase II Transcription R-HSA-73857 1.423767e-01 0.847 0 0
Glycolysis R-HSA-70171 8.444374e-02 1.073 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.679776e-01 0.775 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 8.725174e-02 1.059 0 0
SLC-mediated transport of oligopeptides R-HSA-9959399 1.261370e-01 0.899 0 0
Protein methylation R-HSA-8876725 1.128165e-01 0.948 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 8.695699e-02 1.061 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 9.442824e-02 1.025 0 0
HATs acetylate histones R-HSA-3214847 1.436294e-01 0.843 0 0
Signal amplification R-HSA-392518 1.103115e-01 0.957 0 0
Somitogenesis R-HSA-9824272 1.106759e-01 0.956 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.251303e-01 0.903 0 0
G alpha (z) signalling events R-HSA-418597 9.633730e-02 1.016 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.106759e-01 0.956 0 0
Toll-like Receptor Cascades R-HSA-168898 1.011811e-01 0.995 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 8.808599e-02 1.055 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.168936e-01 0.932 0 0
Disease R-HSA-1643685 1.475397e-01 0.831 0 0
RET signaling R-HSA-8853659 1.273954e-01 0.895 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 1.468575e-01 0.833 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 1.128165e-01 0.948 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 1.128165e-01 0.948 0 0
Interleukin-1 family signaling R-HSA-446652 1.060067e-01 0.975 0 0
Signaling by NOTCH R-HSA-157118 1.264688e-01 0.898 0 0
Signaling by FGFR4 in disease R-HSA-5655291 1.001424e-01 0.999 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 8.725174e-02 1.059 0 0
Assembly Of The HIV Virion R-HSA-175474 8.639870e-02 1.063 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 1.357918e-01 0.867 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 1.468066e-01 0.833 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.468575e-01 0.833 0 0
Signal regulatory protein family interactions R-HSA-391160 1.001424e-01 0.999 0 0
Stimuli-sensing channels R-HSA-2672351 1.248243e-01 0.904 0 0
Regulation of pyruvate metabolism R-HSA-9861718 1.179637e-01 0.928 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.428162e-01 0.845 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 1.117466e-01 0.952 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.357918e-01 0.867 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 1.551041e-01 0.809 0 0
ABC transporter disorders R-HSA-5619084 8.668704e-02 1.062 0 0
ER-Phagosome pathway R-HSA-1236974 1.528253e-01 0.816 0 0
Gap junction degradation R-HSA-190873 1.682048e-01 0.774 0 0
Calcineurin activates NFAT R-HSA-2025928 1.682048e-01 0.774 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 1.682048e-01 0.774 0 0
p75NTR regulates axonogenesis R-HSA-193697 1.682048e-01 0.774 0 0
Unwinding of DNA R-HSA-176974 1.682048e-01 0.774 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.682048e-01 0.774 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.682048e-01 0.774 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 1.682048e-01 0.774 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 1.682048e-01 0.774 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 1.682586e-01 0.774 0 0
Ephrin signaling R-HSA-3928664 1.687579e-01 0.773 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.698126e-01 0.770 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.738783e-01 0.760 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.748365e-01 0.757 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.748365e-01 0.757 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.817610e-01 0.740 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 1.817610e-01 0.740 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.817610e-01 0.740 0 0
E2F mediated regulation of DNA replication R-HSA-113510 1.838189e-01 0.736 0 0
Germ layer formation at gastrulation R-HSA-9754189 1.838189e-01 0.736 0 0
Rap1 signalling R-HSA-392517 1.838189e-01 0.736 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.841252e-01 0.735 0 0
Glucose metabolism R-HSA-70326 1.862341e-01 0.730 0 0
Mitochondrial biogenesis R-HSA-1592230 1.862341e-01 0.730 0 0
HIV Infection R-HSA-162906 1.888952e-01 0.724 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.900314e-01 0.721 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.900314e-01 0.721 0 0
Interleukin-27 signaling R-HSA-9020956 1.900314e-01 0.721 0 0
MAPK3 (ERK1) activation R-HSA-110056 1.900314e-01 0.721 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 1.900314e-01 0.721 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.900314e-01 0.721 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.973229e-01 0.705 0 0
Neuronal System R-HSA-112316 1.979392e-01 0.703 0 0
Circadian clock R-HSA-9909396 2.030891e-01 0.692 0 0
Defective pyroptosis R-HSA-9710421 2.060814e-01 0.686 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 2.064387e-01 0.685 0 0
IRS-mediated signalling R-HSA-112399 2.120598e-01 0.674 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.120598e-01 0.674 0 0
vRNP Assembly R-HSA-192905 2.122051e-01 0.673 0 0
Synthesis of PI R-HSA-1483226 2.122051e-01 0.673 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 2.122051e-01 0.673 0 0
Bicarbonate transporters R-HSA-425381 2.122051e-01 0.673 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 2.122051e-01 0.673 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 2.122051e-01 0.673 0 0
Lagging Strand Synthesis R-HSA-69186 2.149082e-01 0.668 0 0
Basigin interactions R-HSA-210991 2.149082e-01 0.668 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.149082e-01 0.668 0 0
DAP12 interactions R-HSA-2172127 2.168836e-01 0.664 0 0
RMTs methylate histone arginines R-HSA-3214858 2.168836e-01 0.664 0 0
Proteasome assembly R-HSA-9907900 2.168836e-01 0.664 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 2.174537e-01 0.663 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 2.174537e-01 0.663 0 0
Defective ALG9 causes CDG-1l R-HSA-4720454 2.174537e-01 0.663 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 2.174537e-01 0.663 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 2.174537e-01 0.663 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 2.174537e-01 0.663 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 2.174537e-01 0.663 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 2.174537e-01 0.663 0 0
Potassium transport channels R-HSA-1296067 2.174537e-01 0.663 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 2.174537e-01 0.663 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 2.174537e-01 0.663 0 0
Glycogen storage disease type IV (GBE1) R-HSA-3878781 2.174537e-01 0.663 0 0
Signaling by RAS GAP mutants R-HSA-9753510 2.174537e-01 0.663 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 2.174537e-01 0.663 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 2.174537e-01 0.663 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 2.174537e-01 0.663 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 2.174537e-01 0.663 0 0
mRNA Editing: A to I Conversion R-HSA-75064 2.174537e-01 0.663 0 0
The AIM2 inflammasome R-HSA-844615 2.174537e-01 0.663 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 2.174537e-01 0.663 0 0
C6 deamination of adenosine R-HSA-75102 2.174537e-01 0.663 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 2.174537e-01 0.663 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.191237e-01 0.659 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.191237e-01 0.659 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.191237e-01 0.659 0 0
Cardiogenesis R-HSA-9733709 2.191237e-01 0.659 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 2.191237e-01 0.659 0 0
Telomere Maintenance R-HSA-157579 2.222653e-01 0.653 0 0
Signaling by NTRKs R-HSA-166520 2.243474e-01 0.649 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.278572e-01 0.642 0 0
Post-translational protein phosphorylation R-HSA-8957275 2.298020e-01 0.639 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.308479e-01 0.637 0 0
Extension of Telomeres R-HSA-180786 2.314498e-01 0.636 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.320099e-01 0.634 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.320099e-01 0.634 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.346074e-01 0.630 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.346074e-01 0.630 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 2.346074e-01 0.630 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 2.346074e-01 0.630 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 2.354702e-01 0.628 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.389888e-01 0.622 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 2.389888e-01 0.622 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 2.389888e-01 0.622 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 2.407529e-01 0.618 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.413477e-01 0.617 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.413477e-01 0.617 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.413477e-01 0.617 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.413477e-01 0.617 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.413477e-01 0.617 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 2.449479e-01 0.611 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 2.449479e-01 0.611 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 2.449479e-01 0.611 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.450753e-01 0.611 0 0
Calnexin/calreticulin cycle R-HSA-901042 2.450753e-01 0.611 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.450753e-01 0.611 0 0
Signaling by NOTCH2 R-HSA-1980145 2.450753e-01 0.611 0 0
Protein localization R-HSA-9609507 2.552488e-01 0.593 0 0
Regulation of IFNG signaling R-HSA-877312 2.571331e-01 0.590 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.571331e-01 0.590 0 0
Scavenging by Class F Receptors R-HSA-3000484 2.571331e-01 0.590 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.571331e-01 0.590 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.571331e-01 0.590 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.571331e-01 0.590 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.571331e-01 0.590 0 0
Interleukin-35 Signalling R-HSA-8984722 2.571331e-01 0.590 0 0
MET activates RAS signaling R-HSA-8851805 2.571331e-01 0.590 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 2.571331e-01 0.590 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 2.571331e-01 0.590 0 0
OAS antiviral response R-HSA-8983711 2.571331e-01 0.590 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.582980e-01 0.588 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.616716e-01 0.582 0 0
Gluconeogenesis R-HSA-70263 2.616716e-01 0.582 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.616716e-01 0.582 0 0
The NLRP1 inflammasome R-HSA-844455 2.639905e-01 0.578 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 2.639905e-01 0.578 0 0
PLC-gamma1 signalling R-HSA-167021 2.639905e-01 0.578 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 2.639905e-01 0.578 0 0
Axonal growth stimulation R-HSA-209563 2.639905e-01 0.578 0 0
Invadopodia formation R-HSA-8941237 2.639905e-01 0.578 0 0
Classical Kir channels R-HSA-1296053 2.639905e-01 0.578 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 2.639905e-01 0.578 0 0
Activation of BMF and translocation to mitochondria R-HSA-139910 2.639905e-01 0.578 0 0
Base Excision Repair R-HSA-73884 2.650330e-01 0.577 0 0
Translation of Structural Proteins R-HSA-9694635 2.687893e-01 0.571 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.716568e-01 0.566 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 2.716568e-01 0.566 0 0
RNA Polymerase III Transcription R-HSA-74158 2.716568e-01 0.566 0 0
RUNX2 regulates bone development R-HSA-8941326 2.716568e-01 0.566 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 2.731958e-01 0.564 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.768292e-01 0.558 0 0
CD28 dependent Vav1 pathway R-HSA-389359 2.796883e-01 0.553 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 2.796883e-01 0.553 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 2.796883e-01 0.553 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.797460e-01 0.553 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 2.797460e-01 0.553 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 2.797460e-01 0.553 0 0
Insulin receptor signalling cascade R-HSA-74751 2.820764e-01 0.550 0 0
rRNA processing R-HSA-72312 2.888660e-01 0.539 0 0
Generic Transcription Pathway R-HSA-212436 2.893195e-01 0.539 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 2.910241e-01 0.536 0 0
FCERI mediated NF-kB activation R-HSA-2871837 2.946156e-01 0.531 0 0
Tight junction interactions R-HSA-420029 2.962754e-01 0.528 0 0
MET promotes cell motility R-HSA-8875878 2.986984e-01 0.525 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 2.986984e-01 0.525 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 3.021900e-01 0.520 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 3.021900e-01 0.520 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 3.021900e-01 0.520 0 0
Amyloid fiber formation R-HSA-977225 3.066827e-01 0.513 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 3.077624e-01 0.512 0 0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine R-HSA-9735763 3.077624e-01 0.512 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 3.077624e-01 0.512 0 0
Nucleotide catabolism defects R-HSA-9735786 3.077624e-01 0.512 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 3.077624e-01 0.512 0 0
NADE modulates death signalling R-HSA-205025 3.077624e-01 0.512 0 0
Dopamine receptors R-HSA-390651 3.077624e-01 0.512 0 0
Interleukin-38 signaling R-HSA-9007892 3.077624e-01 0.512 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.123405e-01 0.505 0 0
Signaling by ALK R-HSA-201556 3.123405e-01 0.505 0 0
MET activates PTK2 signaling R-HSA-8874081 3.128594e-01 0.505 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 3.128594e-01 0.505 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 3.128594e-01 0.505 0 0
Chromosome Maintenance R-HSA-73886 3.175794e-01 0.498 0 0
Antigen processing-Cross presentation R-HSA-1236975 3.179178e-01 0.498 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 3.201998e-01 0.495 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.241758e-01 0.489 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 3.245649e-01 0.489 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 3.245649e-01 0.489 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.245649e-01 0.489 0 0
FGFR3 ligand binding and activation R-HSA-190239 3.245649e-01 0.489 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 3.245649e-01 0.489 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.260374e-01 0.487 0 0
Selenoamino acid metabolism R-HSA-2408522 3.278780e-01 0.484 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 3.294647e-01 0.482 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.348454e-01 0.475 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 3.397701e-01 0.469 0 0
Telomere Extension By Telomerase R-HSA-171319 3.460598e-01 0.461 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 3.460598e-01 0.461 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 3.467485e-01 0.460 0 0
Phosphorylation of the APC/C R-HSA-176412 3.467485e-01 0.460 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.467485e-01 0.460 0 0
Activation of SMO R-HSA-5635838 3.467485e-01 0.460 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 3.467485e-01 0.460 0 0
IRS activation R-HSA-74713 3.489337e-01 0.457 0 0
G2 Phase R-HSA-68911 3.489337e-01 0.457 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 3.489337e-01 0.457 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 3.489337e-01 0.457 0 0
Reelin signalling pathway R-HSA-8866376 3.489337e-01 0.457 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 3.489337e-01 0.457 0 0
Suppression of autophagy R-HSA-9636569 3.489337e-01 0.457 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 3.489337e-01 0.457 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 3.489337e-01 0.457 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 3.489337e-01 0.457 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 3.535204e-01 0.452 0 0
Translation of Structural Proteins R-HSA-9683701 3.535204e-01 0.452 0 0
Ion homeostasis R-HSA-5578775 3.560439e-01 0.448 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 3.560439e-01 0.448 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.626150e-01 0.441 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 3.670579e-01 0.435 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 3.670579e-01 0.435 0 0
Activation of GABAB receptors R-HSA-991365 3.672706e-01 0.435 0 0
GABA B receptor activation R-HSA-977444 3.672706e-01 0.435 0 0
Synthesis of PA R-HSA-1483166 3.680385e-01 0.434 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 3.686846e-01 0.433 0 0
Fibronectin matrix formation R-HSA-1566977 3.686846e-01 0.433 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 3.686846e-01 0.433 0 0
Synthesis of PG R-HSA-1483148 3.686846e-01 0.433 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 3.686846e-01 0.433 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 3.686851e-01 0.433 0 0
Pyruvate metabolism R-HSA-70268 3.750352e-01 0.426 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 3.772398e-01 0.423 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.791027e-01 0.421 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 3.791027e-01 0.421 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 3.791027e-01 0.421 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 3.800368e-01 0.420 0 0
TBC/RABGAPs R-HSA-8854214 3.810039e-01 0.419 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 3.876586e-01 0.412 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 3.876586e-01 0.412 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 3.876586e-01 0.412 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 3.876586e-01 0.412 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 3.876586e-01 0.412 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 3.876586e-01 0.412 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 3.876586e-01 0.412 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 3.876586e-01 0.412 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 3.876586e-01 0.412 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 3.876586e-01 0.412 0 0
Cam-PDE 1 activation R-HSA-111957 3.876586e-01 0.412 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 3.876586e-01 0.412 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.876586e-01 0.412 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 3.876586e-01 0.412 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.876586e-01 0.412 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 3.876586e-01 0.412 0 0
HIV Life Cycle R-HSA-162587 3.879129e-01 0.411 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.903242e-01 0.409 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 3.903242e-01 0.409 0 0
Peroxisomal protein import R-HSA-9033241 3.920277e-01 0.407 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.926909e-01 0.406 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 3.954970e-01 0.403 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 3.954970e-01 0.403 0 0
Ion channel transport R-HSA-983712 3.991941e-01 0.399 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 4.040001e-01 0.394 0 0
Metabolism of polyamines R-HSA-351202 4.040001e-01 0.394 0 0
Fanconi Anemia Pathway R-HSA-6783310 4.083559e-01 0.389 0 0
Signaling by NOTCH1 R-HSA-1980143 4.101637e-01 0.387 0 0
GAB1 signalosome R-HSA-180292 4.116251e-01 0.385 0 0
Synaptic adhesion-like molecules R-HSA-8849932 4.116251e-01 0.385 0 0
Polo-like kinase mediated events R-HSA-156711 4.116251e-01 0.385 0 0
Platelet sensitization by LDL R-HSA-432142 4.116251e-01 0.385 0 0
Tie2 Signaling R-HSA-210993 4.116251e-01 0.385 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 4.116251e-01 0.385 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 4.145193e-01 0.382 0 0
Activation of HOX genes during differentiation R-HSA-5619507 4.177274e-01 0.379 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 4.177274e-01 0.379 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 4.219445e-01 0.375 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 4.219445e-01 0.375 0 0
Diseases of DNA repair R-HSA-9675135 4.219445e-01 0.375 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 4.240823e-01 0.373 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 4.240823e-01 0.373 0 0
Erythropoietin activates STAT5 R-HSA-9027283 4.240823e-01 0.373 0 0
STAT5 Activation R-HSA-9645135 4.240823e-01 0.373 0 0
G2/M DNA replication checkpoint R-HSA-69478 4.240823e-01 0.373 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 4.240823e-01 0.373 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 4.240823e-01 0.373 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 4.240823e-01 0.373 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 4.240823e-01 0.373 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 4.240823e-01 0.373 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 4.240823e-01 0.373 0 0
HDL clearance R-HSA-8964011 4.240823e-01 0.373 0 0
Nef and signal transduction R-HSA-164944 4.240823e-01 0.373 0 0
Mitochondrial protein import R-HSA-1268020 4.278483e-01 0.369 0 0
tRNA processing in the nucleus R-HSA-6784531 4.278483e-01 0.369 0 0
Signaling by PDGF R-HSA-186797 4.278483e-01 0.369 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 4.279112e-01 0.369 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 4.279112e-01 0.369 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 4.279112e-01 0.369 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 4.316376e-01 0.365 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 4.325509e-01 0.364 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 4.325509e-01 0.364 0 0
Maturation of nucleoprotein R-HSA-9694631 4.325509e-01 0.364 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 4.325509e-01 0.364 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 4.438885e-01 0.353 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 4.438885e-01 0.353 0 0
GPER1 signaling R-HSA-9634597 4.488771e-01 0.348 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 4.530710e-01 0.344 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.530710e-01 0.344 0 0
Signaling by NODAL R-HSA-1181150 4.530710e-01 0.344 0 0
Nephrin family interactions R-HSA-373753 4.530710e-01 0.344 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 4.538109e-01 0.343 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 4.583416e-01 0.339 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 4.583416e-01 0.339 0 0
FGFR3b ligand binding and activation R-HSA-190371 4.583416e-01 0.339 0 0
Recycling of eIF2:GDP R-HSA-72731 4.583416e-01 0.339 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 4.583416e-01 0.339 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 4.583416e-01 0.339 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 4.583416e-01 0.339 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 4.583416e-01 0.339 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 4.583416e-01 0.339 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 4.583416e-01 0.339 0 0
Netrin mediated repulsion signals R-HSA-418886 4.583416e-01 0.339 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 4.583416e-01 0.339 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 4.596871e-01 0.338 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 4.596871e-01 0.338 0 0
Nuclear import of Rev protein R-HSA-180746 4.596871e-01 0.338 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 4.629438e-01 0.334 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 4.731597e-01 0.325 0 0
ERK/MAPK targets R-HSA-198753 4.731597e-01 0.325 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 4.752897e-01 0.323 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 4.752897e-01 0.323 0 0
Signaling by FGFR2 in disease R-HSA-5655253 4.753997e-01 0.323 0 0
PI3K Cascade R-HSA-109704 4.753997e-01 0.323 0 0
Unfolded Protein Response (UPR) R-HSA-381119 4.865352e-01 0.313 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 4.871397e-01 0.312 0 0
Inositol phosphate metabolism R-HSA-1483249 4.903424e-01 0.310 0 0
Type I hemidesmosome assembly R-HSA-446107 4.905648e-01 0.309 0 0
phospho-PLA2 pathway R-HSA-111995 4.905648e-01 0.309 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 4.905648e-01 0.309 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 4.905648e-01 0.309 0 0
Fructose biosynthesis R-HSA-5652227 4.905648e-01 0.309 0 0
Interleukin-9 signaling R-HSA-8985947 4.905648e-01 0.309 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 4.905648e-01 0.309 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 4.905648e-01 0.309 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 4.905648e-01 0.309 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 4.905648e-01 0.309 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 4.905648e-01 0.309 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 4.927956e-01 0.307 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 4.927956e-01 0.307 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 4.927956e-01 0.307 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 4.927956e-01 0.307 0 0
Ribavirin ADME R-HSA-9755088 4.927956e-01 0.307 0 0
Leishmania phagocytosis R-HSA-9664417 4.945012e-01 0.306 0 0
Parasite infection R-HSA-9664407 4.945012e-01 0.306 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 4.945012e-01 0.306 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 4.979389e-01 0.303 0 0
Meiosis R-HSA-1500620 5.053960e-01 0.296 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 5.058468e-01 0.296 0 0
Notch-HLH transcription pathway R-HSA-350054 5.119616e-01 0.291 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 5.119616e-01 0.291 0 0
Fructose metabolism R-HSA-5652084 5.119616e-01 0.291 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 5.119616e-01 0.291 0 0
Ethanol oxidation R-HSA-71384 5.119616e-01 0.291 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 5.119616e-01 0.291 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 5.119616e-01 0.291 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 5.119616e-01 0.291 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 5.142197e-01 0.289 0 0
Meiotic synapsis R-HSA-1221632 5.142197e-01 0.289 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 5.207747e-01 0.283 0 0
WNT mediated activation of DVL R-HSA-201688 5.208729e-01 0.283 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 5.208729e-01 0.283 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 5.208729e-01 0.283 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 5.208729e-01 0.283 0 0
Enzymatic degradation of Dopamine by monoamine oxidase R-HSA-379398 5.208729e-01 0.283 0 0
Interleukin-21 signaling R-HSA-9020958 5.208729e-01 0.283 0 0
mRNA Editing R-HSA-75072 5.208729e-01 0.283 0 0
MAPK1 (ERK2) activation R-HSA-112411 5.208729e-01 0.283 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 5.208729e-01 0.283 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 5.208729e-01 0.283 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 5.208729e-01 0.283 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 5.208729e-01 0.283 0 0
Regulated proteolysis of p75NTR R-HSA-193692 5.208729e-01 0.283 0 0
Interleukin-1 processing R-HSA-448706 5.208729e-01 0.283 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 5.208729e-01 0.283 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 5.208729e-01 0.283 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 5.299670e-01 0.276 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.306441e-01 0.275 0 0
Growth hormone receptor signaling R-HSA-982772 5.306441e-01 0.275 0 0
Carnitine shuttle R-HSA-200425 5.306441e-01 0.275 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 5.317592e-01 0.274 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 5.354535e-01 0.271 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 5.354535e-01 0.271 0 0
Regulation of endogenous retroelements R-HSA-9842860 5.397117e-01 0.268 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 5.488328e-01 0.261 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 5.488328e-01 0.261 0 0
Complex III assembly R-HSA-9865881 5.488328e-01 0.261 0 0
2-LTR circle formation R-HSA-164843 5.493795e-01 0.260 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 5.493795e-01 0.260 0 0
PI3K/AKT activation R-HSA-198203 5.493795e-01 0.260 0 0
Enzymatic degradation of dopamine by COMT R-HSA-379397 5.493795e-01 0.260 0 0
DNA replication initiation R-HSA-68952 5.493795e-01 0.260 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 5.493795e-01 0.260 0 0
Signal attenuation R-HSA-74749 5.493795e-01 0.260 0 0
CASP4 inflammasome assembly R-HSA-9948001 5.493795e-01 0.260 0 0
Receptor Mediated Mitophagy R-HSA-8934903 5.493795e-01 0.260 0 0
Signaling by Leptin R-HSA-2586552 5.493795e-01 0.260 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 5.498733e-01 0.260 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 5.498733e-01 0.260 0 0
Rab regulation of trafficking R-HSA-9007101 5.517167e-01 0.258 0 0
Ca2+ pathway R-HSA-4086398 5.537257e-01 0.257 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 5.537257e-01 0.257 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 5.602412e-01 0.252 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 5.640256e-01 0.249 0 0
G protein gated Potassium channels R-HSA-1296059 5.665204e-01 0.247 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 5.665204e-01 0.247 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 5.665204e-01 0.247 0 0
Acyl chain remodelling of PS R-HSA-1482801 5.665204e-01 0.247 0 0
Laminin interactions R-HSA-3000157 5.665204e-01 0.247 0 0
HDMs demethylate histones R-HSA-3214842 5.665204e-01 0.247 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 5.665204e-01 0.247 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 5.665204e-01 0.247 0 0
TGFBR3 expression R-HSA-9839394 5.665204e-01 0.247 0 0
RSV-host interactions R-HSA-9833110 5.671326e-01 0.246 0 0
Disorders of transmembrane transporters R-HSA-5619115 5.701387e-01 0.244 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 5.757506e-01 0.240 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 5.761918e-01 0.239 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 5.761918e-01 0.239 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 5.761918e-01 0.239 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 5.761918e-01 0.239 0 0
Ionotropic activity of kainate receptors R-HSA-451306 5.761918e-01 0.239 0 0
Signaling by APC mutants R-HSA-4839744 5.761918e-01 0.239 0 0
vRNA Synthesis R-HSA-192814 5.761918e-01 0.239 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 5.837020e-01 0.234 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 5.837020e-01 0.234 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 5.914991e-01 0.228 0 0
Signaling by Insulin receptor R-HSA-74752 5.944943e-01 0.226 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 5.944943e-01 0.226 0 0
GABA receptor activation R-HSA-977443 5.990910e-01 0.223 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 6.003753e-01 0.222 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 6.003753e-01 0.222 0 0
Packaging Of Telomere Ends R-HSA-171306 6.003753e-01 0.222 0 0
Cristae formation R-HSA-8949613 6.003753e-01 0.222 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 6.003753e-01 0.222 0 0
Triglyceride biosynthesis R-HSA-75109 6.003753e-01 0.222 0 0
Synthesis of PE R-HSA-1483213 6.003753e-01 0.222 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 6.014102e-01 0.221 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 6.014102e-01 0.221 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 6.014102e-01 0.221 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 6.014102e-01 0.221 0 0
Signaling by AXIN mutants R-HSA-4839735 6.014102e-01 0.221 0 0
Signaling by AMER1 mutants R-HSA-4839748 6.014102e-01 0.221 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 6.014102e-01 0.221 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 6.014102e-01 0.221 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 6.014102e-01 0.221 0 0
Sodium/Calcium exchangers R-HSA-425561 6.014102e-01 0.221 0 0
Activation of RAC1 R-HSA-428540 6.014102e-01 0.221 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 6.014102e-01 0.221 0 0
Integration of provirus R-HSA-162592 6.014102e-01 0.221 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 6.017571e-01 0.221 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 6.029815e-01 0.220 0 0
Viral Messenger RNA Synthesis R-HSA-168325 6.104677e-01 0.214 0 0
Sensory processing of sound R-HSA-9659379 6.163792e-01 0.210 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 6.165398e-01 0.210 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 6.165398e-01 0.210 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 6.165398e-01 0.210 0 0
Prednisone ADME R-HSA-9757110 6.165398e-01 0.210 0 0
Amine ligand-binding receptors R-HSA-375280 6.178279e-01 0.209 0 0
NCAM signaling for neurite out-growth R-HSA-375165 6.216434e-01 0.206 0 0
Bacterial Infection Pathways R-HSA-9824439 6.227566e-01 0.206 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 6.251294e-01 0.204 0 0
Maple Syrup Urine Disease R-HSA-9865114 6.251294e-01 0.204 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 6.251294e-01 0.204 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 6.251294e-01 0.204 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 6.251294e-01 0.204 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 6.251294e-01 0.204 0 0
Synthesis of GDP-mannose R-HSA-446205 6.251294e-01 0.204 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 6.251294e-01 0.204 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 6.251294e-01 0.204 0 0
Pervasive developmental disorders R-HSA-9005895 6.251294e-01 0.204 0 0
Disorders of Nervous System Development R-HSA-9697154 6.251294e-01 0.204 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 6.251294e-01 0.204 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 6.251294e-01 0.204 0 0
Interleukin-15 signaling R-HSA-8983432 6.251294e-01 0.204 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 6.305529e-01 0.200 0 0
DARPP-32 events R-HSA-180024 6.321972e-01 0.199 0 0
Platelet calcium homeostasis R-HSA-418360 6.321972e-01 0.199 0 0
Regulation of gene expression in beta cells R-HSA-210745 6.321972e-01 0.199 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 6.326147e-01 0.199 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 6.429816e-01 0.192 0 0
Ion transport by P-type ATPases R-HSA-936837 6.433789e-01 0.192 0 0
Neurotransmitter clearance R-HSA-112311 6.473505e-01 0.189 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 6.473505e-01 0.189 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 6.473505e-01 0.189 0 0
Interleukin-37 signaling R-HSA-9008059 6.473505e-01 0.189 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 6.474385e-01 0.189 0 0
Processing of SMDT1 R-HSA-8949664 6.474385e-01 0.189 0 0
Diseases of nucleotide metabolism R-HSA-9735804 6.474385e-01 0.189 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 6.474385e-01 0.189 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 6.474385e-01 0.189 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 6.474385e-01 0.189 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 6.474385e-01 0.189 0 0
Phospholipid metabolism R-HSA-1483257 6.496261e-01 0.187 0 0
Extracellular matrix organization R-HSA-1474244 6.592429e-01 0.181 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 6.620043e-01 0.179 0 0
Molecules associated with elastic fibres R-HSA-2129379 6.620043e-01 0.179 0 0
FOXO-mediated transcription R-HSA-9614085 6.659848e-01 0.177 0 0
Co-stimulation by CD28 R-HSA-389356 6.669439e-01 0.176 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 6.680807e-01 0.175 0 0
Removal of the Flap Intermediate R-HSA-69166 6.684212e-01 0.175 0 0
Retrograde neurotrophin signalling R-HSA-177504 6.684212e-01 0.175 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 6.684212e-01 0.175 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 6.684212e-01 0.175 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 6.684212e-01 0.175 0 0
FGFR3c ligand binding and activation R-HSA-190372 6.684212e-01 0.175 0 0
Hydrolysis of LPC R-HSA-1483115 6.684212e-01 0.175 0 0
Physiological factors R-HSA-5578768 6.684212e-01 0.175 0 0
Malate-aspartate shuttle R-HSA-9856872 6.684212e-01 0.175 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 6.684212e-01 0.175 0 0
Non-canonical inflammasome activation R-HSA-9686114 6.684212e-01 0.175 0 0
Acyl chain remodeling of CL R-HSA-1482798 6.684212e-01 0.175 0 0
Inwardly rectifying K+ channels R-HSA-1296065 6.761642e-01 0.170 0 0
Signaling by WNT in cancer R-HSA-4791275 6.761642e-01 0.170 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 6.761642e-01 0.170 0 0
Cardiac conduction R-HSA-5576891 6.783575e-01 0.169 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.825028e-01 0.166 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 6.881563e-01 0.162 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 6.881563e-01 0.162 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.881563e-01 0.162 0 0
Telomere C-strand synthesis initiation R-HSA-174430 6.881563e-01 0.162 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 6.881563e-01 0.162 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 6.881563e-01 0.162 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 6.881563e-01 0.162 0 0
Synthesis of 12-eicosatetraenoic acid derivatives R-HSA-2142712 6.881563e-01 0.162 0 0
Signaling by Activin R-HSA-1502540 6.881563e-01 0.162 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.881563e-01 0.162 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 6.881563e-01 0.162 0 0
Other semaphorin interactions R-HSA-416700 6.881563e-01 0.162 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 6.898373e-01 0.161 0 0
Recycling of bile acids and salts R-HSA-159418 6.898373e-01 0.161 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 6.912934e-01 0.160 0 0
Meiotic recombination R-HSA-912446 7.006471e-01 0.155 0 0
The phototransduction cascade R-HSA-2514856 7.006471e-01 0.155 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 7.030312e-01 0.153 0 0
Acyl chain remodelling of PC R-HSA-1482788 7.030312e-01 0.153 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.030312e-01 0.153 0 0
Effects of PIP2 hydrolysis R-HSA-114508 7.030312e-01 0.153 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 7.067179e-01 0.151 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 7.067179e-01 0.151 0 0
Phase 4 - resting membrane potential R-HSA-5576886 7.067179e-01 0.151 0 0
Atorvastatin ADME R-HSA-9754706 7.067179e-01 0.151 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 7.067179e-01 0.151 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 7.067179e-01 0.151 0 0
Fructose catabolism R-HSA-70350 7.067179e-01 0.151 0 0
Differentiation of T cells R-HSA-9945266 7.067179e-01 0.151 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 7.067179e-01 0.151 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 7.067179e-01 0.151 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 7.067179e-01 0.151 0 0
Neurexins and neuroligins R-HSA-6794361 7.112877e-01 0.148 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 7.127883e-01 0.147 0 0
ECM proteoglycans R-HSA-3000178 7.127883e-01 0.147 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 7.157545e-01 0.145 0 0
eNOS activation R-HSA-203615 7.157545e-01 0.145 0 0
RA biosynthesis pathway R-HSA-5365859 7.157545e-01 0.145 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 7.157545e-01 0.145 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 7.157545e-01 0.145 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 7.157545e-01 0.145 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 7.200847e-01 0.143 0 0
Amino acids regulate mTORC1 R-HSA-9639288 7.216345e-01 0.142 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 7.218473e-01 0.142 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 7.218473e-01 0.142 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 7.241758e-01 0.140 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 7.241758e-01 0.140 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 7.241758e-01 0.140 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 7.241758e-01 0.140 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 7.241758e-01 0.140 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 7.241758e-01 0.140 0 0
Coenzyme A biosynthesis R-HSA-196783 7.241758e-01 0.140 0 0
Disorders of Developmental Biology R-HSA-9675151 7.241758e-01 0.140 0 0
Galactose catabolism R-HSA-70370 7.241758e-01 0.140 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 7.241758e-01 0.140 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 7.241758e-01 0.140 0 0
Acyl chain remodelling of PE R-HSA-1482839 7.280166e-01 0.138 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 7.398271e-01 0.131 0 0
IRE1alpha activates chaperones R-HSA-381070 7.405082e-01 0.130 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 7.405954e-01 0.130 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 7.405954e-01 0.130 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 7.405954e-01 0.130 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 7.405954e-01 0.130 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 7.405954e-01 0.130 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 7.405954e-01 0.130 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.405954e-01 0.130 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 7.405954e-01 0.130 0 0
Synthesis of 15-eicosatetraenoic acid derivatives R-HSA-2142770 7.405954e-01 0.130 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 7.405954e-01 0.130 0 0
HDACs deacetylate histones R-HSA-3214815 7.414574e-01 0.130 0 0
Cleavage of the damaged purine R-HSA-110331 7.511964e-01 0.124 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 7.560385e-01 0.121 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 7.560385e-01 0.121 0 0
Mismatch Repair R-HSA-5358508 7.560385e-01 0.121 0 0
PKA activation R-HSA-163615 7.560385e-01 0.121 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 7.560385e-01 0.121 0 0
Apoptotic factor-mediated response R-HSA-111471 7.560385e-01 0.121 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 7.621352e-01 0.118 0 0
Depurination R-HSA-73927 7.621352e-01 0.118 0 0
Elastic fibre formation R-HSA-1566948 7.621352e-01 0.118 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 7.621352e-01 0.118 0 0
Mitochondrial protein degradation R-HSA-9837999 7.628515e-01 0.118 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 7.705632e-01 0.113 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.705632e-01 0.113 0 0
Specification of the neural plate border R-HSA-9834899 7.705632e-01 0.113 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 7.705632e-01 0.113 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 7.705632e-01 0.113 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 7.705632e-01 0.113 0 0
Other interleukin signaling R-HSA-449836 7.705632e-01 0.113 0 0
STING mediated induction of host immune responses R-HSA-1834941 7.705632e-01 0.113 0 0
Integrin cell surface interactions R-HSA-216083 7.717623e-01 0.113 0 0
Pentose phosphate pathway R-HSA-71336 7.726544e-01 0.112 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 7.726544e-01 0.112 0 0
snRNP Assembly R-HSA-191859 7.777168e-01 0.109 0 0
Metabolism of non-coding RNA R-HSA-194441 7.777168e-01 0.109 0 0
Regulation of beta-cell development R-HSA-186712 7.777168e-01 0.109 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 7.827652e-01 0.106 0 0
Interleukin-2 family signaling R-HSA-451927 7.827652e-01 0.106 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 7.827652e-01 0.106 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 7.837111e-01 0.106 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 7.842239e-01 0.106 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 7.842239e-01 0.106 0 0
Co-inhibition by CTLA4 R-HSA-389513 7.842239e-01 0.106 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 7.842239e-01 0.106 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 7.842239e-01 0.106 0 0
Acyl chain remodelling of PI R-HSA-1482922 7.842239e-01 0.106 0 0
Pregnenolone biosynthesis R-HSA-196108 7.842239e-01 0.106 0 0
tRNA Aminoacylation R-HSA-379724 7.860998e-01 0.105 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.867496e-01 0.104 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 7.867496e-01 0.104 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.939434e-01 0.100 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 7.970720e-01 0.099 0 0
Phenylalanine metabolism R-HSA-8964208 7.970720e-01 0.099 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 7.970720e-01 0.099 0 0
Acyl chain remodelling of PG R-HSA-1482925 7.970720e-01 0.099 0 0
Early Phase of HIV Life Cycle R-HSA-162594 7.970720e-01 0.099 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 8.011831e-01 0.096 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.018067e-01 0.096 0 0
Intra-Golgi traffic R-HSA-6811438 8.018067e-01 0.096 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 8.020799e-01 0.096 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 8.020799e-01 0.096 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.077449e-01 0.093 0 0
Mitochondrial calcium ion transport R-HSA-8949215 8.091558e-01 0.092 0 0
Post-translational protein modification R-HSA-597592 8.103717e-01 0.091 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 8.107605e-01 0.091 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.107605e-01 0.091 0 0
Depyrimidination R-HSA-73928 8.107605e-01 0.091 0 0
FGFR2 alternative splicing R-HSA-6803529 8.205208e-01 0.086 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.205208e-01 0.086 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 8.205208e-01 0.086 0 0
LDL clearance R-HSA-8964038 8.205208e-01 0.086 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 8.205208e-01 0.086 0 0
Protein-protein interactions at synapses R-HSA-6794362 8.207838e-01 0.086 0 0
PI Metabolism R-HSA-1483255 8.211285e-01 0.086 0 0
Surfactant metabolism R-HSA-5683826 8.275911e-01 0.082 0 0
Leishmania parasite growth and survival R-HSA-9664433 8.307880e-01 0.081 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 8.307880e-01 0.081 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.312096e-01 0.080 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.312096e-01 0.080 0 0
Termination of O-glycan biosynthesis R-HSA-977068 8.312096e-01 0.080 0 0
Interleukin receptor SHC signaling R-HSA-912526 8.312096e-01 0.080 0 0
Interleukin-20 family signaling R-HSA-8854691 8.312096e-01 0.080 0 0
Formation of the ureteric bud R-HSA-9830674 8.312096e-01 0.080 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 8.312096e-01 0.080 0 0
Biosynthesis of maresins R-HSA-9018682 8.312096e-01 0.080 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 8.312096e-01 0.080 0 0
XBP1(S) activates chaperone genes R-HSA-381038 8.330846e-01 0.079 0 0
Nucleosome assembly R-HSA-774815 8.354909e-01 0.078 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 8.354909e-01 0.078 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 8.354909e-01 0.078 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 8.412624e-01 0.075 0 0
Mitochondrial RNA degradation R-HSA-9836573 8.412624e-01 0.075 0 0
Signaling by TGFBR3 R-HSA-9839373 8.430619e-01 0.074 0 0
Synthesis of PC R-HSA-1483191 8.503153e-01 0.070 0 0
Formation of the nephric duct R-HSA-9830364 8.507171e-01 0.070 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.507171e-01 0.070 0 0
Interleukin-7 signaling R-HSA-1266695 8.507171e-01 0.070 0 0
Gene Silencing by RNA R-HSA-211000 8.531463e-01 0.069 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 8.562814e-01 0.067 0 0
NGF-stimulated transcription R-HSA-9031628 8.572621e-01 0.067 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 8.582452e-01 0.066 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.596092e-01 0.066 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 8.596092e-01 0.066 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.596092e-01 0.066 0 0
TRP channels R-HSA-3295583 8.596092e-01 0.066 0 0
Urea cycle R-HSA-70635 8.596092e-01 0.066 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.596092e-01 0.066 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 8.607797e-01 0.065 0 0
Cell surface interactions at the vascular wall R-HSA-202733 8.622797e-01 0.064 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 8.679721e-01 0.061 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 8.679721e-01 0.061 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.679721e-01 0.061 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 8.679721e-01 0.061 0 0
Signaling by BMP R-HSA-201451 8.679721e-01 0.061 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 8.679721e-01 0.061 0 0
Azathioprine ADME R-HSA-9748787 8.702787e-01 0.060 0 0
Aspirin ADME R-HSA-9749641 8.729877e-01 0.059 0 0
G alpha (i) signalling events R-HSA-418594 8.741478e-01 0.058 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.754375e-01 0.058 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.758373e-01 0.058 0 0
HIV elongation arrest and recovery R-HSA-167287 8.758373e-01 0.058 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.758373e-01 0.058 0 0
Pausing and recovery of HIV elongation R-HSA-167290 8.758373e-01 0.058 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.758373e-01 0.058 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 8.821954e-01 0.054 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 8.821954e-01 0.054 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.821954e-01 0.054 0 0
Reproduction R-HSA-1474165 8.822773e-01 0.054 0 0
DNA methylation R-HSA-5334118 8.832344e-01 0.054 0 0
mRNA Capping R-HSA-72086 8.832344e-01 0.054 0 0
Adipogenesis R-HSA-9843745 8.860280e-01 0.053 0 0
G alpha (q) signalling events R-HSA-416476 8.864119e-01 0.052 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 8.877665e-01 0.052 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 8.879518e-01 0.052 0 0
GPCR downstream signalling R-HSA-388396 8.889224e-01 0.051 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.901913e-01 0.051 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.901913e-01 0.051 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 8.930925e-01 0.049 0 0
G alpha (s) signalling events R-HSA-418555 8.952210e-01 0.048 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 8.954260e-01 0.048 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 8.958451e-01 0.048 0 0
Aspartate and asparagine metabolism R-HSA-8963693 8.967341e-01 0.047 0 0
RNA Polymerase I Transcription R-HSA-73864 8.970322e-01 0.047 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.013195e-01 0.045 0 0
Metabolism of proteins R-HSA-392499 9.017253e-01 0.045 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.065527e-01 0.043 0 0
G-protein beta:gamma signalling R-HSA-397795 9.086743e-01 0.042 0 0
Nuclear RNA decay R-HSA-9930044 9.086743e-01 0.042 0 0
HCMV Late Events R-HSA-9610379 9.106096e-01 0.041 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.141168e-01 0.039 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.141168e-01 0.039 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.141168e-01 0.039 0 0
Heme degradation R-HSA-189483 9.141168e-01 0.039 0 0
Interferon gamma signaling R-HSA-877300 9.161313e-01 0.038 0 0
Triglyceride metabolism R-HSA-8979227 9.163656e-01 0.038 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.192352e-01 0.037 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.192352e-01 0.037 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.204094e-01 0.036 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.240489e-01 0.034 0 0
Heme signaling R-HSA-9707616 9.279510e-01 0.032 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.285760e-01 0.032 0 0
Platelet homeostasis R-HSA-418346 9.302880e-01 0.031 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.314638e-01 0.031 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.325353e-01 0.030 0 0
Voltage gated Potassium channels R-HSA-1296072 9.328335e-01 0.030 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.328335e-01 0.030 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.328335e-01 0.030 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.328335e-01 0.030 0 0
Metabolism of folate and pterines R-HSA-196757 9.328335e-01 0.030 0 0
SLC transporter disorders R-HSA-5619102 9.353696e-01 0.029 0 0
Purine salvage R-HSA-74217 9.368374e-01 0.028 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 9.406029e-01 0.027 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.406029e-01 0.027 0 0
Diseases associated with N-glycosylation of proteins R-HSA-3781860 9.406029e-01 0.027 0 0
Kidney development R-HSA-9830369 9.439576e-01 0.025 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.439576e-01 0.025 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 9.441441e-01 0.025 0 0
HIV Transcription Elongation R-HSA-167169 9.441441e-01 0.025 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 9.441441e-01 0.025 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.441441e-01 0.025 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.441441e-01 0.025 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 9.441441e-01 0.025 0 0
Diseases of Immune System R-HSA-5260271 9.441441e-01 0.025 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 9.441441e-01 0.025 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.441441e-01 0.025 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.441441e-01 0.025 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.474744e-01 0.023 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.474744e-01 0.023 0 0
Maturation of spike protein R-HSA-9694548 9.474744e-01 0.023 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.474744e-01 0.023 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.474811e-01 0.023 0 0
Signaling by GPCR R-HSA-372790 9.476178e-01 0.023 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.506063e-01 0.022 0 0
HIV Transcription Initiation R-HSA-167161 9.506063e-01 0.022 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.506063e-01 0.022 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.506063e-01 0.022 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.506063e-01 0.022 0 0
FCGR activation R-HSA-2029481 9.511293e-01 0.022 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.535516e-01 0.021 0 0
Metabolism of cofactors R-HSA-8978934 9.542646e-01 0.020 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.563215e-01 0.019 0 0
Integration of energy metabolism R-HSA-163685 9.572173e-01 0.019 0 0
Methylation R-HSA-156581 9.589264e-01 0.018 0 0
Potassium Channels R-HSA-1296071 9.592416e-01 0.018 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 9.607779e-01 0.017 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.613761e-01 0.017 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.613761e-01 0.017 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.627440e-01 0.016 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.658462e-01 0.015 0 0
Peptide ligand-binding receptors R-HSA-375276 9.674914e-01 0.014 0 0
Metal ion SLC transporters R-HSA-425410 9.678835e-01 0.014 0 0
Interleukin-10 signaling R-HSA-6783783 9.680904e-01 0.014 0 0
Formation of the cornified envelope R-HSA-6809371 9.695128e-01 0.013 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.697024e-01 0.013 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.697994e-01 0.013 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.697994e-01 0.013 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.732955e-01 0.012 0 0
Complex IV assembly R-HSA-9864848 9.732955e-01 0.012 0 0
tRNA processing R-HSA-72306 9.742965e-01 0.011 0 0
Nucleotide biosynthesis R-HSA-8956320 9.763872e-01 0.010 0 0
Glucuronidation R-HSA-156588 9.777963e-01 0.010 0 0
Paracetamol ADME R-HSA-9753281 9.791213e-01 0.009 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.803674e-01 0.009 0 0
Dectin-2 family R-HSA-5621480 9.815391e-01 0.008 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.826410e-01 0.008 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.836772e-01 0.007 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.836772e-01 0.007 0 0
Neurotransmitter release cycle R-HSA-112310 9.838503e-01 0.007 0 0
RAB geranylgeranylation R-HSA-8873719 9.846516e-01 0.007 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.846516e-01 0.007 0 0
Endogenous sterols R-HSA-211976 9.855679e-01 0.006 0 0
Nucleotide salvage R-HSA-8956321 9.855679e-01 0.006 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.865996e-01 0.006 0 0
Complex I biogenesis R-HSA-6799198 9.872397e-01 0.006 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.880017e-01 0.005 0 0
Xenobiotics R-HSA-211981 9.880017e-01 0.005 0 0
Metabolism of nucleotides R-HSA-15869 9.884663e-01 0.005 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.893918e-01 0.005 0 0
Mitochondrial translation elongation R-HSA-5389840 9.894517e-01 0.005 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.894517e-01 0.005 0 0
Transport of small molecules R-HSA-382551 9.897554e-01 0.004 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.900253e-01 0.004 0 0
Metabolism of steroid hormones R-HSA-196071 9.900253e-01 0.004 0 0
Regulation of insulin secretion R-HSA-422356 9.905240e-01 0.004 0 0
O-linked glycosylation of mucins R-HSA-913709 9.906211e-01 0.004 0 0
Transcription of the HIV genome R-HSA-167172 9.906211e-01 0.004 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.917080e-01 0.004 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.922033e-01 0.003 0 0
Metabolism of porphyrins R-HSA-189445 9.922033e-01 0.003 0 0
Purine catabolism R-HSA-74259 9.926691e-01 0.003 0 0
Respiratory electron transport R-HSA-611105 9.930339e-01 0.003 0 0
PPARA activates gene expression R-HSA-1989781 9.935835e-01 0.003 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.938334e-01 0.003 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.941505e-01 0.003 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.946126e-01 0.002 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.949346e-01 0.002 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.953087e-01 0.002 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.957896e-01 0.002 0 0
Drug ADME R-HSA-9748784 9.964675e-01 0.002 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.970914e-01 0.001 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.970914e-01 0.001 0 0
Visual phototransduction R-HSA-2187338 9.975619e-01 0.001 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.977272e-01 0.001 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.979075e-01 0.001 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.979854e-01 0.001 0 0
Collagen formation R-HSA-1474290 9.983303e-01 0.001 0 0
Mitochondrial translation initiation R-HSA-5368286 9.987736e-01 0.001 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.988470e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.988810e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.990767e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.990992e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.992431e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.994153e-01 0.000 0 0
Keratinization R-HSA-6805567 9.994980e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.996071e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.996745e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.996848e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.997547e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.998077e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.998589e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.998611e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.998828e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999240e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.999387e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999504e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.999507e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999565e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 9.999892e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999967e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.999981e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999987e-01 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 9.999989e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999989e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.999997e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999999e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 9.999999e-01 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways