PKG2

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
O00571 S83 Sugiyama DDX3X DBX DDX3 sKDKDAyssFGsRsDsRGKssFFsDRGsGsRGRFDDRGRsD
O14579 S99 Sugiyama COPE PELQAVRMFADyLAHEsRRDsIVAELDREMsRSVDVTNTTF
O14617 S658 Sugiyama AP3D1 PRO0039 DERPRAVFHEEEQRRPKHRPsEADEEELARRREARKQEQAN
O14618 S267 Sugiyama CCS DGLTIWEERGRPIAGKGRKEsAQPPAHL_____________
O14974 S692 Sugiyama PPP1R12A MBS MYPT1 PVRDEEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIG
O14974 S695 Sugiyama PPP1R12A MBS MYPT1 DEEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSR
O14974 S910 Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O14974 T696 Sugiyama PPP1R12A MBS MYPT1 EEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSRS
O14980 S1055 Sugiyama XPO1 CRM1 LEEREIALRQADEEKHKRQMsVPGIFNPHEIPEEMCD____
O15067 S1053 Sugiyama PFAS KIAA0361 RGLRERMGPSYCLPPTFPKAsVPREPGGPsPRVAILREEGS
O15067 S215 Sugiyama PFAS KIAA0361 LDSWDLDFYTKRFQELQRNPstVEAFDLAQsNsEHSRHWFF
O15085 T1292 Sugiyama ARHGEF11 KIAA0380 GERPEQEDMGLCSLEHLPPRtRNsGIWEsPELDRNLAEDAS
O15143 S328 Sugiyama ARPC1B ARC41 KAssEGGtAAGAGLDsLHKNsVsQIsVLsGGKAKCSQFCTT
O15212 T107 Sugiyama PFDN6 HKE2 PFD6 IKRYESQLRDLERQsEQQREtLAQLQQEFQRAQAAKAGAPG
O15372 S290 Sugiyama EIF3H EIF3S3 QQQQKHQYQQRRQQENMQRQsRGEPPLPEEDLsKLFKPPQP
O43847 S94 Sugiyama NRDC NRD1 ENSRVARLGADEsEEEGRRGsLsNAGDPEIVKsPsDPKQYR
O60293 S42 Sugiyama ZFC3H1 CCDC131 KIAA0546 PSRC2 LEDGEIsDDDNNSQIRSRsssSsSGGGLLPYPRRRPPHSAR
O60343 T749 Sugiyama TBC1D4 AS160 KIAA0603 ENEIRQDTASESSDGEGRKRtSstCsNEsLsVGGTSVTPRR
O60841 S107 Sugiyama EIF5B IF2 KIAA0741 NEEEFtsKDKKKKGQKGKKQsFDDNDsEELEDKDsKSKKTA
O60841 S182 Sugiyama EIF5B IF2 KIAA0741 DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O60841 S183 Sugiyama EIF5B IF2 KIAA0741 GsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKN
O75369 S2532 Sugiyama FLNB FLN1L FLN3 TABP TAP ASKVTSKGAGLSKAFVGQKssFLVDCSKAGSNMLLIGVHGP
O75494 S133 Sugiyama SRSF10 FUSIP1 FUSIP2 SFRS13A TASR yDRYRRSRSRSYERRRsRsRsFDyNYRRsYsPRNSRPTGRP
O76021 S314 Sugiyama RSL1D1 CATX11 CSIG PBK1 L12 RNFEKQKERKKKRQQARKtAsVLsKDDVAPEsGDtTVKKPE
O76074 S102 ELM PDE5A PDE5 PLQQsPRADNSAPGTPTRKIsAsEFDRPLRPIVVKDSEGTV
O95155 S105 Sugiyama UBE4B HDNB1 KIAA0684 UFD2 LsssPsNsLEtQsQsLsRsQsMDIDGVSCEKsMsQVDVDsG
O95613 S44 Sugiyama PCNT KIAA0402 PCNT2 QRKTKGDSSHSEKKTAKRKGsAVDAsVQEEsPVTKEDsALC
O95714 S2928 Sugiyama HERC2 ILLGRIRAEEEDLAAVPFLAsDNEEEEDEKGNSGsLIRKKA
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00491 S176 Sugiyama PNP NP GDRFPAMsDAyDRtMRQRALstWKQMGEQRELQEGTYVMVA
P00533 T430 SIGNOR|PSP EGFR ERBB ERBB1 HER1 WPENRTDLHAFENLEIIRGRtKQHGQFSLAVVSLNITSLGL
P00533 T693 PSP EGFR ERBB ERBB1 HER1 IVRKRtLRRLLQERELVEPLtPsGEAPNQALLRILKETEFK
P00568 S58 Sugiyama AK1 stGDLLRSEVSSGSARGKKLsEIMEKGQLVPLETVLDMLRD
P01023 S273 Sugiyama A2M CPAMD5 FWP007 LYTYGKPVPGHVTVSICRKYsDAsDCHGEDSQAFCEKFSGQ
P04075 S346 Sugiyama ALDOA ALDA EEYVKRALANsLACQGKytPsGQAGAAAsEsLFVsNHAy__
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04075 Y364 Sugiyama ALDOA ALDA tPsGQAGAAAsEsLFVsNHAy____________________
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04626 T686 EPSD|PSP ERBB2 HER2 MLN19 NEU NGL VLGVVFGILIKRRQQKIRKYtMRRLLQETELVEPLtPsGAM
P04792 S78 SIGNOR HSPB1 HSP27 HSP28 LPPAAIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVs
P04792 S82 SIGNOR|Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04792 T143 SIGNOR HSPB1 HSP27 HSP28 KHEERQDEHGyIsRCFTRKYtLPPGVDPTQVSSsLsPEGtL
P05204 S29 ELM HMGN2 HMG17 DAKGDKAKVKDEPQRRsARLsAKPAPPKPEPKPKKAPAKKG
P05362 S43 Sugiyama ICAM1 GPGNAQTSVSPSKVILPRGGsVLVTCstsCDQPKLLGIETP
P05455 S94 Sugiyama SSB KSKAELMEIsEDKTKIRRsPsKPLPEVTDEyKNDVKNRsVY
P05783 S305 Sugiyama KRT18 CYK18 PIG46 QSAEVGAAETTLTELRRtVQsLEIDLDsMRNLKAsLENsLR
P05787 S330 Sugiyama KRT8 CYK8 MNRNISRLQAEIEGLKGQRAsLEAAIADAEQRGELAIKDAN
P06733 Y44 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P06737 S430 Sugiyama PYGL KHLDRIVALFPKDVDRLRRMsLIEEEGSKRINMAHLCIVGS
P06748 S242 Sugiyama NPM1 NPM sKGQEsFKKQEKtPKtPKGPssVEDIKAKMQAsIEKGGsLP
P06899 S37 Sugiyama H2BC11 H2BFR HIST1H2BJ KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISS
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195 S320 Sugiyama LDHB GLtsVINQKLKDDEVAQLKKsADtLWDIQKDLKDL______
P07195 T302 Sugiyama LDHB YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07814 S739 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 TKVEATKNETSAPFKERPtPsLNNNCttsEDsLVLyNRVAV
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900 S399 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNLVKK
P07900 S460 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA QFSKNIKLGIHEDsQNRKKLsELLRyytsAsGDEMVsLKDY
P07900 S623 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA tyGWTANMERIMKAQALRDNstMGyMAAKKHLEINPDHsII
P07900 S63 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPN
P08238 S206 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB KEDQtEyLEERRVKEVVKKHsQFIGyPItLyLEKEREKEIs
P08238 S391 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNIVKK
P08238 S45 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238 S452 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB AFSKNLKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEy
P08238 S460 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 S58 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPN
P08238 S615 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB tyGWTANMERIMKAQALRDNstMGyMMAKKHLEINPDHPIV
P08581 S985 EPSD|PSP MET GsELVRYDARVHtPHLDRLVsARsVsPttEMVsNEsVDyRA
P08670 S325 Sugiyama VIM NNDALRQAKQESTEYRRQVQsLtCEVDALKGtNEsLERQMR
P09132 S69 Sugiyama SRP19 IQDVCSAVGLNVFLEKNKMYsREWNRDVQYRGRVRVQLKQE
P09525 S125 Sugiyama ANXA4 ANX4 DEGCLIEILASRTPEEIRRIsQtYQQQYGRSLEDDIRSDTS
P09619 S254 SIGNOR|PSP PDGFRB PDGFR PDGFR1 MCIVIGNEVVNFEWTYPRKEsGRLVEPVTDFLLDMPYHIRS
P09619 S712 SIGNOR|PSP PDGFRB PDGFR PDGFR1 yLHRNKHTFLQHHSDKRRPPsAELysNALPVGLPLPSHVSL
P09972 S45 Sugiyama ALDOC ALDC APGKGILAADEsVGsMAKRLsQIGVENtEENRRLYRQVLFs
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG47 S57 Sugiyama UBB PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0CG48 S57 Sugiyama UBC PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P10412 S36 Sugiyama H1-4 H1F4 HIST1H1E EKtPVKKKARKsAGAAKRKAsGPPVsELItKAVAASKERsG
P10412 S55 Sugiyama H1-4 H1F4 HIST1H1E AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P10412 S58 Sugiyama H1-4 H1F4 HIST1H1E PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P10809 S398 Sugiyama HSPD1 HSP60 LDVttsEyEKEKLNERLAKLsDGVAVLKVGGtsDVEVNEKK
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P13569 S660 ELM CFTR ABCC7 FsSKLMGCDSFDQFSAERRNsILTETLHRFsLEGDAPVSWT
P13569 S700 ELM CFTR ABCC7 TEtKKQsFKQTGEFGEKRKNsILNPINsIRKFsIVQKTPLQ
P13569 S737 ELM CFTR ABCC7 TPLQMNGIEEDSDEPLERRLsLVPDSEQGEAILPRIsVIST
P13569 S768 ELM CFTR ABCC7 ILPRIsVISTGPTLQARRRQsVLNLMTHSVNQGQNIHRKTT
P13569 S795 ELM CFTR ABCC7 HSVNQGQNIHRKTTAsTRKVsLAPQANLTELDIYsRRLsQE
P13569 S813 ELM CFTR ABCC7 KVsLAPQANLTELDIYsRRLsQEtGLEISEEINEEDLKECF
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 S732 Sugiyama EEF2 EF2 DAIHRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQCP
P13861 S58 Sugiyama PRKAR2A PKR2 PRKAR2 TRLREARAPAsVLPAAtPRQsLGHPPPEPGPDRVADAKGDs
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14625 S106 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14866 S544 Sugiyama HNRNPL HNRPL P/OKcl.14 LGVKRPSSVKVFSGKsERsssGLLEWEsKSDALETLGFLNH
P15880 S190 Sugiyama RPS2 RPS4 WGNKIGKPHTVPCKVTGRCGsVLVRLIPAPRGtGIVsAPVP
P16333 S85 Sugiyama NCK1 NCK ASIVKNLKDTLGIGKVKRKPsVPDsAsPADDsFVDPGERLy
P16402 S37 Sugiyama H1-3 H1F3 HIST1H1D KtPVKKKAKKAGATAGKRKAsGPPVsELItKAVAASKERsG
P16402 S56 Sugiyama H1-3 H1F3 HIST1H1D AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16402 S59 Sugiyama H1-3 H1F3 HIST1H1D PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P16403 S55 Sugiyama H1-2 H1F2 HIST1H1C AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403 S58 Sugiyama H1-2 H1F2 HIST1H1C PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P16930 S164 Sugiyama FAH KENALMPNWLHLPVGYHGRAssVVVSGTPIRRPMGQMKPDD
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17544 S44 Sugiyama ATF7 ATFA LAVHKHKHEMTLKFGPARtDsVIIADQtPtPtRFLKNCEEV
P17844 S519 Sugiyama DDX5 G17P1 HELR HLR1 AGKRGGFNTFRDRENYDRGYssLLKRDFGAKTQNGVYSAAN
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P18858 S901 Sugiyama LIG1 DKQPEQATTSAQVACLYRKQsQIQNQQGEDsGsDPEDTY__
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P20290 S173 Sugiyama BTF3 NACB OK/SW-cl.8 QLGADsLtsLRRLAEALPKQsVDGKAPLAtGEDDDDEVPDL
P22087 S124 Sugiyama FBL FIB1 FLRN DALVTKNLVPGEsVyGEKRVsIsEGDDKIEyRAWNPFRSKL
P22626 S189 Sugiyama HNRNPA2B1 HNRPA2B1 IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P23527 S37 Sugiyama H2BC17 H2BFH H2BFN HIST1H2BO KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISS
P24534 S141 Sugiyama EEF1B2 EEF1B EF1B ERLAQYESKKAKKPALVAKssILLDVKPWDDEtDMAKLEEC
P25054 S1389 Sugiyama APC DP2.5 PKsPPEHYVQETPLMFsRCTsVSsLDSFESRSIASSVQSEP
P25205 S447 Sugiyama MCM3 EQGRVTIAKAGIHARLNARCsVLAAANPVyGRyDQyKTPME
P25789 T10 Sugiyama PSMA4 HC9 PSC9 ___________MSRRyDsRttIFsPEGRLYQVEYAMEAIGH
P26232 T657 Sugiyama CTNNA2 CAPR EDDsDFEQEDYDVRsRtsVQtEDDQLIAGQsARAIMAQLPQ
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26641 T287 Sugiyama EEF1G EF1G PRO1608 EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P27708 S1859 Sugiyama CAD RGIPGLPDGRFHLPPRIHRAsDPGLPAEEPKEKSSRKVAEP
P29350 S553 SIGNOR|PSP PTPN6 HCP PTP1C EsEyGNITyPPAMKNAHAKAsRtssKHKEDVyENLHTKNKR
P29350 S556 SIGNOR|PSP PTPN6 HCP PTP1C yGNITyPPAMKNAHAKAsRtssKHKEDVyENLHTKNKREEK
P29350 S557 SIGNOR|PSP PTPN6 HCP PTP1C GNITyPPAMKNAHAKAsRtssKHKEDVyENLHTKNKREEKV
P29401 S104 Sugiyama TKT AVWAEAGFLAEAELLNLRKIssDLDGHPVPKQAFtDVATGs
P29401 S473 Sugiyama TKT AtEKAVELAANTKGICFIRTsRPENAIIyNNNEDFQVGQAK
P29474 S1177 EPSD|PSP NOS3 EDIFGLTLRTQEVTSRIRtQsFsLQERQLRGAVPWAFDPPG
P29474 S633 EPSD|PSP NOS3 FNsISCSDPLVssWRRKRKEssNtDSAGALGTLRFCVFGLG
P29474 T495 EPSD|PSP NOS3 YQPDPWKGSAAKGTGITRKKtFKEVANAVKISASLMGTVMA
P30086 S52 Sugiyama PEBP1 PBP PEBP AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P30086 T51 Sugiyama PEBP1 PBP PEBP GAAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDP
P30533 S242 Sugiyama LRPAP1 A2MRAP TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P31939 S554 Sugiyama ATIC PURH OK/SW-cl.86 VSISSDAFFPFRDNVDRAKRsGVAyIAAPSGsAADKVVIEA
P32119 S112 Sugiyama PRDX2 NKEFB TDPX1 KEGGLGPLNIPLLADVTRRLsEDyGVLKTDEGIAYRGLFII
P32929 S377 SIGNOR|EPSD|PSP CTH ASVLKNDRDVLGISDtLIRLsVGLEDEEDLLEDLDQALKAA
P33316 S120 Sugiyama DUT PsKRARPAEVGGMQLRFARLsEHAtAPTRGsARAAGYDLYS
P33778 S37 Sugiyama H2BC3 H2BFF HIST1H2BB KAITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISS
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P35221 T658 Sugiyama CTNNA1 LDDsDFEtEDFDVRsRtsVQtEDDQLIAGQsARAIMAQLPQ
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37837 S13 Sugiyama TALDO1 TAL TALDO TALDOR ________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P39019 Y48 Sugiyama RPS19 LKVPEWVDtVKLAKHKELAPyDENWFytRAAstARHLYLRG
P39019 Y54 Sugiyama RPS19 VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39023 S265 Sugiyama RPL3 OK/SW-cl.32 HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P41236 S24 Sugiyama PPP1R2 IPP2 STAsHRPIKGILKNKtsttssMVAsAEQPRGNVDEELSKKs
P42677 T74 Sugiyama RPS27 MPS1 VLCVGCSTVLCQPTGGKARLtEGCsFRRKQH__________
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43243 S195 Sugiyama MATR3 KIAA0723 RDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRsQEsGyyD
P43243 S234 Sugiyama MATR3 KIAA0723 yDRMDyEDDRLRDGERCRDDsFFGEtsHNyHKFDsEyERMG
P43243 T150 Sugiyama MATR3 KIAA0723 EDKItPENLPQILLQLKRRRtEEGPtLsyGRDGRsAtREPP
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46459 S207 Sugiyama NSF KAENSSLNLIGKAKTKENRQsIINPDWNFEKMGIGGLDKEF
P46777 S176 Sugiyama RPL5 MSTP030 GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46777 S230 Sugiyama RPL5 MSTP030 yLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAHAAIREN
P46779 S115 Sugiyama RPL28 HMIRKNKYRPDLRMAAIRRAsAILRSQKPVMVKRKRTRPTK
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49327 S1997 Sugiyama FASN FAS DGLLENQTPEFFQDVCKPKYsGtLNLDRVTREACPELDYFV
P49419 S84 Sugiyama ALDH7A1 ATQ1 EVIttyCPANNEPIARVRQAsVADyEEtVKKAREAWKIWAD
P49588 S237 Sugiyama AARS1 AARS LVFIQYNREADGILKPLPKKsIDtGMGLERLVsVLQNKMSN
P49736 S229 Sugiyama MCM2 BM28 CCNL1 CDCL1 KIAA0030 sHGHNVFKERIsDMCKENREsLVVNyEDLAAREHVLAYFLP
P49840 Y279 Sugiyama GSK3A LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P49841 Y216 Sugiyama GSK3B LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P50552 S157 ELM VASP EVEQQKRQQPGPSEHIERRVsNAGGPPAPPAGGPPPPPGPP
P50552 S239 ELM VASP GGAGAPGLAAAIAGAKLRKVsKQEEAsGGPTAPKAESGRSG
P50552 T278 ELM VASP SGGGGLMEEMNAMLARRRKAtQVGEKtPKDEsANQEEPEAR
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51858 S107 Sugiyama HDGF HMG1L2 WEIENNPtVKASGYQSsQKKsCVEEPEPEPEAAEGDGDKKG
P52298 S13 Sugiyama NCBP2 CBP20 PIG55 ________MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQE
P52298 Y14 Sugiyama NCBP2 CBP20 PIG55 _______MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQEK
P52943 S115 Sugiyama CRIP2 CRP2 AARAEERKAsGPPKGPsRAssVttFtGEPNtCPRCSKKVYF
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P60174 S21 Sugiyama TPI1 TPI MAPSRKFFVGGNWKMNGRKQsLGELIGtLNAAKVPADtEVV
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61353 S86 Sugiyama RPL27 SKIKSFVKVyNyNHLMPtRysVDIPLDKtVVNKDVFRDPAL
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P62241 S160 Sugiyama RPS8 OK/SW-cl.83 KRSKKIQKKYDERKKNAKIssLLEEQFQQGKLLACIASRPG
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62269 S96 Sugiyama RPS18 D6S218E QYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLKK
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62424 T84 Sugiyama RPL7A SURF-3 SURF3 QRQRAILyKRLKVPPAINQFtQALDRQTAtQLLKLAHKYRP
P62701 T247 Sugiyama RPS4X CCG2 RPS4 SCAR VIGKGNKPWIsLPRGKGIRLtIAEERDKRLAAKQSSG____
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62805 S48 Sugiyama H4C1 H4/A H4FA HIST1H4A; H4C2 H4/I H4FI HIST1H4B; H4C3 H4/G H4FG HIST1H4C; H4C4 H4/B H4FB HIST1H4D; H4C5 H4/J H4FJ HIST1H4E; H4C6 H4/C H4FC HIST1H4F; H4C8 H4/H H4FH HIST1H4H; H4C9 H4/M H4FM HIST1H4I; H4C11 H4/E H4FE HIST1H4J; H4C12 H4/D H4FD HIST1H4K; H4C13 H4/K H4FK HIST1H4L; H4C14 H4/N H4F2 H4FN HIST2H4 HIST2H4A; H4C15 H4/O H4FO HIST2H4B; H4C16 H4-16 HIST4H4 QGItKPAIRRLARRGGVKRIsGLIyEETRGVLKVFLENVIR
P62899 S15 Sugiyama RPL31 ______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62906 S64 Sugiyama RPL10A NEDD6 QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62906 T9 Sugiyama RPL10A NEDD6 ____________MSSKVsRDtLyEAVREVLHGNQRKRRKFL
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 S14 Sugiyama RPL8 _______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P62917 T146 Sugiyama RPL8 LARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVISSANRAVV
P62937 T157 Sugiyama PPIA CYPA NIVEAMERFGsRNGKTSKKItIADCGQLE____________
P62942 T22 Sugiyama FKBP1A FKBP1 FKBP12 GVQVEtIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRD
P62979 S123 Sugiyama RPS27A UBA80 UBCEP1 LKYYKVDENGKIsRLRRECPsDECGAGVFMAsHFDRHyCGK
P62979 S57 Sugiyama RPS27A UBA80 UBCEP1 PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGA
P62987 S57 Sugiyama UBA52 UBCEP2 PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGI
P63146 S142 Sugiyama UBE2B RAD6B UBCH1 ANSQAAQLYQENKREYEKRVsAIVEQsWNDS__________
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P67809 S102 Sugiyama YBX1 NSEP1 YB1 EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P67809 S209 Sugiyama YBX1 NSEP1 YB1 RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P67809 T108 Sugiyama YBX1 NSEP1 YB1 QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68104 T432 Sugiyama EEF1A1 EEF1A EF1A LENG7 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68363 S439 Sugiyama TUBA1B SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P78345 S253 Sugiyama RPP38 DtsFEDLsKPKRKLADGRQAsVtLQPLKIKKLIPNPNKIRK
P78362 S494 Sugiyama SRPK2 GSPLTEQEESSPSHDRSRtVsAsstGDLPKAKTRAADLLVN
P83731 S86 Sugiyama RPL24 EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098 S12 Sugiyama RPL19 _________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
Q01970 S1105 SIGNOR|ELM|iPTMNet|EPSD PLCB3 EMNEREKKELQKILDRKRHNsIsEAKMRDKHKKEAELTEIN
Q01970 S26 SIGNOR|ELM|iPTMNet|EPSD PLCB3 PGVHALQLEPPTVVETLRRGsKFIKWDEETSSRNLVTLRVD
Q02543 S123 Sugiyama RPL18A AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK
Q03393 S19 SIGNOR|iPTMNet|EPSD|PSP PTS __MSTEGGGRRCQAQVSRRIsFsASHRLYSKFLSDEENLKL
Q04695 S32 Sugiyama KRT17 SsIKGSSGLGGGsSRTsCRLsGGLGAGsCRLGSAGGLGSTL
Q04917 S145 Sugiyama YWHAH YWHA1 KMKGDYYRYLAEVASGEKKNsVVEAsEAAyKEAFEISKEQM
Q05048 S377 Sugiyama CSTF1 TQAVFNHtEDyVLLPDERTIsLCCWDSRTAERRNLLSLGHN
Q05639 T432 Sugiyama EEF1A2 EEF1AL STN VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q06210 S261 Sugiyama GFPT1 GFAT GFPT GsQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDA
Q06481 S111 Sugiyama APLP2 APPL2 CQEMYPELQITNVMEANQRVsIDNWCRRDKKQCKSRFVTPF
Q07157 S1153 Sugiyama TJP1 ZO1 EEPAPLsyDsRPRYEQAPRAsALRHEEQPAPGyDtHGRLRP
Q07866 S524 Sugiyama KLC1 KLC KNS2 QRVAEVLNDPENMEKRRsREsLNVDVVKYESGPDGGEEVSM
Q08211 S1026 Sugiyama DHX9 DDX9 LKP NDH2 HKEKRKILTTEGRNALIHKssVNCPFssQDMKYPSPFFVFG
Q08211 S449 Sugiyama DHX9 DDX9 LKP NDH2 FIQNDRAAECNIVVTQPRRIsAVsVAERVAFERGEEPGKSC
Q08AD1 S1313 Sugiyama CAMSAP2 CAMSAP1L1 KIAA1078 sLNtGDNEsVHsGKRtPRsEsVEGFLsPsRCGsRNGEKDWE
Q09028 S147 Sugiyama RBBP4 RBAP48 VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC
Q09161 S22 Sugiyama NCBP1 CBP80 NCBP SRRRHsDENDGGQPHKRRKtsDANEtEDHLEsLICKVGEKS
Q09161 T21 Sugiyama NCBP1 CBP80 NCBP MSRRRHsDENDGGQPHKRRKtsDANEtEDHLEsLICKVGEK
Q12965 T935 Sugiyama MYO1E MYO1C VLQVSIGPGLPKNSRPTRRNttQNtGySsGtQNANyPVRAA
Q12982 S114 Sugiyama BNIP2 NIP2 EFEWEDDLPKPKTTEVIRKGsItEyTAAEEKEDGRRWRMFR
Q13206 S829 Sugiyama DDX10 sEDMENKISDTKKKQGMKKRsNsEVEDVGPTsHNRKKARWD
Q13237 S11 Sugiyama PRKG2 PRKGR2 __________MGNGSVKPKHsKHPDGHsGNLTTDALRNKVT
Q13237 S110 Sugiyama PRKG2 PRKGR2 GGSPLQAsPDKVPLEVHRKtsGLVSLHSRRGAKAGVSAEPT
Q13237 S18 Sugiyama PRKG2 PRKGR2 ___MGNGSVKPKHsKHPDGHsGNLTTDALRNKVTELERELR
Q13237 S285 Sugiyama PRKG2 PRKGR2 IMRRTAQARDEQYRNFLRSVsLLKNLPEDKLTKIIDCLEVE
Q13237 S431 Sugiyama PRKG2 PRKGR2 DDEKRHAKRSMSNWKLSKALsLEMIQLKEKVARFSSSSPFQ
Q13237 T109 Sugiyama PRKG2 PRKGR2 QGGSPLQAsPDKVPLEVHRKtsGLVSLHSRRGAKAGVSAEP
Q13247 S297 Sugiyama SRSF6 SFRS6 SRP55 RSRSPKENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsP
Q13625 T739 Sugiyama TP53BP2 ASPP2 BBP EALRKKLSNAPRPLKKRssItEPEGPNGPNIQKLLYQRTTI
Q14135 S59 Sugiyama VGLL4 KIAA0121 SALsSHRTGPPPIsPSKRKFsMEPGDEDLDCDNDHVSKMSR
Q14151 S818 Sugiyama SAFB2 KIAA0138 QHYGDDRHGHGGPPERHGRDsRDGWGGyGsDKRLsEGRGLP
Q14152 S584 Sugiyama EIF3A EIF3S10 KIAA0139 EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14157 S852 Sugiyama UBAP2L KIAA0144 NICE4 LDyysIPFPtPttPLtGRDGsLAsNPysGDLtKFGRGDASS
Q14247 S282 Sugiyama CTTN EMS1 QKDyKTGFGGKFGVQsERQDsAAVGFDyKEKLAKHEsQQDy
Q14432 S312 Sugiyama PDE3A sssVVsAEMSGCSSKSHRRtsLPCIPREQLMGHSEWDHKRG
Q14432 T311 Sugiyama PDE3A RsssVVsAEMSGCSSKSHRRtsLPCIPREQLMGHSEWDHKR
Q14566 S271 Sugiyama MCM6 VPDVSKLSTPGARAEtNsRVsGVDGyEtEGIRGLRALGVRD
Q14671 S709 Sugiyama PUM1 KIAA0099 PUMH1 LGGFGTAVANSNTGSGSRRDsLtGSsDLYKRTSSSLTPIGH
Q14697 S190 Sugiyama GANAB G2AN KIAA0088 VNARGLLEFEHQRAPRVsQGsKDPAEGDGAQPEEtPRDGDK
Q14847 S146 SIGNOR|ELM|iPTMNet|EPSD|PSP|Sugiyama LASP1 MLN50 FEKSRMGPsGGEGMEPERRDsQDGssyRRPLEQQQPHHIPt
Q14847 S61 iPTMNet|EPSD|Sugiyama LASP1 MLN50 MKNYKGYEKKPYCNAHyPKQsFtMVADtPENLRLKQQSELQ
Q14847 S99 Sugiyama LASP1 MLN50 ELQsQVRYKEEFEKNKGKGFsVVADtPELQRIKKTQDQIsN
Q14980 S1991 Sugiyama NUMA1 NMP22 NUMA QPIQIAEGTGITTRQQRKRVsLEPHQGPGtPEsKKATSCFP
Q15036 S437 Sugiyama SNX17 KIAA0064 PLLEsPDAtREsMVKLSsKLsAVsLRGIGsPSTDASAsDVH
Q15036 S440 Sugiyama SNX17 KIAA0064 EsPDAtREsMVKLSsKLsAVsLRGIGsPSTDASAsDVHGNF
Q15042 S340 Sugiyama RAB3GAP1 KIAA0066 RAB3GAP PQCLLGDFVTEFFKICRRKEsTDEILGRSAFEEEGKETADI
Q15185 S72 Sugiyama PTGES3 P23 TEBP EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE
Q15424 S794 Sugiyama SAFB HAP HET SAFB1 EREGQHYPERHGGPERHGRDsRDGWGGyGsDKRMsEGRGLP
Q15428 S153 Sugiyama SF3A2 SAP62 LFQIDYPEIAEGIMPRHRFMsAyEQRIEPPDRRWQYLLMAA
Q15654 S400 Sugiyama TRIP6 OIP1 DATSQIHCIEDFHRKFAPRCsVCGGAIMPEPGQEETVRIVA
Q15785 S93 Sugiyama TOMM34 URCC3 DCTSALALVPFSIKPLLRRAsAyEALEKYPMAYVDYKTVLQ
Q15942 S505 Sugiyama ZYX DQANRPHCVPDYHKQYAPRCsVCSEPIMPEPGRDETVRVVA
Q16576 S146 Sugiyama RBBP7 RBAP46 VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC
Q16778 S37 Sugiyama H2BC21 H2BFQ HIST2H2BE KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIss
Q3B726 S316 Sugiyama POLR1F TWISTNB GsDssGyQsDHKKKKKKRKHsEEAEFtPPLKCsPKRKGKSN
Q53EL6 S76 Sugiyama PDCD4 H731 NAKAKRRLRKNssRDsGRGDsVsDsGsDALRSGLtVPtsPK
Q58FF6 S34 Sugiyama HSP90AB4P IFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDIIPN
Q58FF7 S185 Sugiyama HSP90AB3P HSP90BC KEDQtEyLEERRVKEVVKKHsQFIGyPItLyLEKEQDKEIs
Q58FF7 S488 Sugiyama HSP90AB3P HSP90BC TYGWTANMEQIMKAQALRDNstMGyMMAKKHLEINPDHPIM
Q58FF7 S58 Sugiyama HSP90AB3P HSP90BC IFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FF8 S58 Sugiyama HSP90AB2P HSP90BB IFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q5T0N5 S488 Sugiyama FNBP1L C1orf39 TOCA1 NEAWLSEVEGKTGGRGDRRHssDINHLVtQGREsPEGsytD
Q5T1M5 S1162 Sugiyama FKBP15 KIAA0674 EAGstVAGAALRPsHHsQRssLsGDEEDELFKGATLKALRP
Q5T5C0 S692 Sugiyama STXBP5 LLGL3 YGSNDPYRREPRSPRKsRQPsGAGLCDIsEGtVVPEDRCKS
Q5TAX3 S1384 Sugiyama TUT4 KIAA0191 ZCCHC11 DAGHVRRECPEVKLARQRNssVAAAQLVRNLVNAQQVAGSA
Q5VT52 S1070 Sugiyama RPRD2 KIAA0460 HSPC099 TATDQQQQEEHYRIETRVsssCLDLPDSTEEKGAPIETLGy
Q5VTE0 T432 Sugiyama EEF1A1P5 EEF1AL3 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q6DN03 S37 Sugiyama H2BC20P HIST2H2BC KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWC
Q6DRA6 S37 Sugiyama H2BC19P HIST2H2BD KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWC
Q6GYQ0 S860 Sugiyama RALGAPA1 GARNL1 KIAA0884 TULIP1 DEFIAERLRSGNASTMTRRGssPGsLEIPKDLPDILNKQNQ
Q6P158 S605 Sugiyama DHX57 SLNGPPEKVANIICTQPRRIsAISVAERVAKERAERVGLTV
Q6P1J9 S174 Sugiyama CDC73 C1orf28 HRPT2 AARLEGHKEGIVQTEQIRSLsEAMsVEKIAAIKAKIMAKKR
Q6P2Q9 T1404 Sugiyama PRPF8 PRPC8 RVWAEYALKRQEAIAQNRRLtLEDLEDSWDRGIPRINTLFQ
Q6PD62 S932 Sugiyama CTR9 KIAA0155 SH2BP1 KKGGEFDEFVNDDtDDDLPIsKKKKRRKGsGsEQEGEDEEG
Q6PJG9 S585 Sugiyama LRFN4 SALM3 sPTPKAHPPRsPPPRPQRsCsLDLGDAGCYGYARRLGGAWA
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6UXD5 S719 Sugiyama SEZ6L2 PSK UNQ1903/PRO4349 CQKIMTCADPGEIANGHRTAsDAGFPVGSHVQYRCLPGYSL
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q6ZN18 S206 Sugiyama AEBP2 DEGYGTGGGGSSATSGGRRGsLEMssDGEPLSRMDSEDSIS
Q6ZRI6 S455 Sugiyama C15orf39 FP6578 EAEEKTWLPSCRKEKLQPRLsEHsGPPIVIRDsPVPCtPPA
Q71U36 S439 Sugiyama TUBA1A TUBA3 SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q71UM5 T74 Sugiyama RPS27L VLCVGCSTVLCQPTGGKARLtEGCsFRRKQH__________
Q7KZI7 S40 Sugiyama MARK2 EMK1 TLGHLDSKPssKSNMIRGRNsAtsADEQPHIGNyRLLKTIG
Q7Z4S6 T862 Sugiyama KIF21A KIAA1708 KIF2 DKVAGKVTRKLsssDAPAQDtGssAAAVETDASRTGAQQKM
Q7Z4V5 S454 Sugiyama HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 VRPEEKQQAKPVKVERTRKRsEGFsMDRKVEKKKEPSVEEK
Q7Z5L9 S360 Sugiyama IRF2BP2 EANGANGSKAVARTARKRKPsPEPEGEVGPPKINGEAQPWL
Q7Z5L9 S455 Sugiyama IRF2BP2 AGGSHASKDANQVHSTTRRNsNsPPsPssMNQRRLGPREVG
Q7Z5L9 Y17 Sugiyama IRF2BP2 ____MAAAVAVAAASRRQsCyLCDLPRMPWAMIWDFTEPVC
Q86UK7 S851 Sugiyama ZNF598 HTDFCNREKPLSTKSKKNKKsAWQATtQQAGLDCRVCPTCQ
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q8IWX8 S904 Sugiyama CHERP DAN26 SCAF6 KGVGVALDDPyENyRRNKsysFIARMKARDECK________
Q8N201 S495 Sugiyama INTS1 KIAA1440 UNQ1821/PRO3434 KFLAMVFQDLLTNKDDYLRAsRALLREIIKQTKHEINFQAF
Q8N257 S37 Sugiyama H2BC26 H2BU1 HIST3H2BB KAVTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIss
Q8N684 S166 Sugiyama CPSF7 PGKVLNGEKVDVRPAtRQNLsQFEAQARKRECVRVPRGGIP
Q8NBA8 S132 Sugiyama DTWD2 PLLAACLPQDKCKVKIGRRFsEERDPELSTVCRKSGTLILY
Q8NBJ5 S607 Sugiyama COLGALT1 GLT25D1 PSEC0241 DRAKSQKMREQQALSREAKNsDVLQsPLDsAARDEL_____
Q8ND56 T384 Sugiyama LSM14A C19orf13 FAM61A RAP55 RAP55A DKTKsFFDNIsCDDNRERRPtWAEERRLNAETFGIPLRPNR
Q8NE71 S105 Sugiyama ABCF1 ABC50 KKDVDDDGEEKELMERLKKLsVPtsDEEDEVPAPKPRGGKK
Q8TCY9 S447 Sugiyama URGCP KIAA1507 URG4 FVKRIRAIVGNVLRAPCRRVsVEDMAHAARKLGLKVDEDCE
Q8TD19 T333 Sugiyama NEK9 KIAA1995 NEK8 NERCC REMEEKVTLLNAPTKRPRsstVtEAPIAVVTSRTSEVYVWG
Q8TD47 T247 Sugiyama RPS4Y2 RPS4Y2P VIGNGNKPWISLPRGKGIRLtIAEERDKRLAAKQSSG____
Q8TEW0 S958 Sugiyama PARD3 PAR3 PAR3A VDDDDEGMEtLEEDTEESSRsGREsVstAsDQPsHsLERQM
Q8TF44 S237 Sugiyama C2CD4C FAM148C KIAA1957 NLF3 DTGSSAESSPFGSPLLSRSVsLLKGFAQDSQAKVSQLRHSV
Q8WUX9 S417 Sugiyama CHMP7 DLPDNPRNRHFtNsVPNPRIsDAELEAELEKLsLsEGGLVP
Q8WZ42 S20761 Sugiyama TTN GGSPIINYVVQKRDAERKSWsTVTTECsKTSFRVANLEEGK
Q8WZ42 S20768 Sugiyama TTN YVVQKRDAERKSWsTVTTECsKTSFRVANLEEGKSYFFRVF
Q92538 S174 Sugiyama GBF1 KIAA0248 NESVCEIMQSCFRICFEMRLsELLRKSAEHTLVDMVQLLFT
Q92945 S193 Sugiyama KHSRP FUBP2 DSGCKVQIsPDsGGLPERsVsLtGAPEsVQKAKMMLDDIVS
Q92945 S333 Sugiyama KHSRP FUBP2 DRNEyGsRIGGGIDVPVPRHsVGVVIGRSGEMIKKIQNDAG
Q969S3 S38 Sugiyama ZNF622 ZPR9 MQRAHYKTDWHRYNLRRKVAsMAPVTAEGFQERVRAQRAVA
Q96G46 S236 Sugiyama DUS3L QQLRKREVRFERAEQALRRFsQGPtPAAAVPEGTAAEGAPR
Q96JP5 S85 Sugiyama ZFP91 ZNF757 FKSG11 AAAVSRRRKAEYPRRRRssPsARPPDVPGQQPQAAKsPsPV
Q96P16 S285 Sugiyama RPRD1A P15RS YKRKLARVSLVRKELRSRIQsLPDLSRLPNVTGSHMHLPFA
Q96RS6 S373 Sugiyama NUDCD1 CML66 EGLTWPELVIGDKQGELIRDsAQCAAIAERLMHLtsEELNP
Q96RU3 S497 Sugiyama FNBP1 FBP17 KIAA0554 AWLAEVEGRLPARSEQARRQsGLyDSQNPPTVNNCAQDREs
Q99584 S32 Sugiyama S100A13 SIETVVTTFFTFARQEGRKDsLsVNEFKELVTQQLPHLLKD
Q9BQG0 S1166 Sugiyama MYBBP1A P160 RPKLEKKDAKEIPsAtQsPIsKKRKKKGFLPETKKRKKRKs
Q9BQG0 S1186 Sugiyama MYBBP1A P160 sKKRKKKGFLPETKKRKKRKsEDGtPAEDGtPAATGGsQPP
Q9BX95 T114 Sugiyama SGPP1 SPP1 AAELGPAsPRRAGALRRNsLtGEEGQLARVSNWPLYCLFCF
Q9BXS5 S305 Sugiyama AP1M1 CLTNM KHSHSRIEYMIKAKSQFKRRstANNVEIHIPVPNDADsPKF
Q9BXS5 T306 Sugiyama AP1M1 CLTNM HSHSRIEYMIKAKSQFKRRstANNVEIHIPVPNDADsPKFK
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9C0C2 S429 Sugiyama TNKS1BP1 KIAA1741 TAB182 EEEAKGDAHLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAA
Q9H0B6 S428 Sugiyama KLC2 NKPIWMHAEEREESKDKRRDsAPyGEyGsWYKACKVDsPtV
Q9H2U1 S268 Sugiyama DHX36 DDX36 KIAA1488 MLEL1 RHAU YIERGKGSACRIVCTQPRRIsAISVAERVAAERAEsCGSGN
Q9H6H4 S152 Sugiyama REEP4 C8orf20 PP432 AAVQAATKSQGALAGRLRsFsMQDLRSISDAPAPAyHDPLy
Q9H788 S315 Sugiyama SH2D4A PPP1R38 SH2A LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9H7D7 S121 Sugiyama WDR26 CDW2 MIP2 PRO0852 ASSSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLN
Q9H9A7 S456 Sugiyama RMI1 C9orf76 HSLNNKILNREVVNYVQKRNsQISNENDCNLQSCSLRSSEN
Q9HAU0 S471 Sugiyama PLEKHA5 KIAA1686 PEPP2 MARYPEGYRtLPRNSKTRPEsICSVtPsTHDKTLGPGAEEK
Q9NP61 S367 Sugiyama ARFGAP3 ARFGAP1 DsyFTSSSSYFDEPVELRsssFssWDDssDSyWKKETSKDT
Q9NQX3 S280 Sugiyama GPHN GPH KIAA1385 TAsLsttPsEsPRAQAtsRLstAsCPtPKVQSRCSsKENIL
Q9NQZ2 S462 Sugiyama UTP3 CRLZ1 SAS10 RAKIRRRGQVREVRKEEQRYsGELsGIRAGVKKSIKLK___
Q9NVN8 S513 Sugiyama GNL3L PNRHQMGWAKRNVDHRPKsNsMVDVCsVDRRSVLQRIMETD
Q9NXH9 S514 Sugiyama TRMT1 ALWDIMRCWEKECPVKRERLsETsPAFRILsVEPRLQANFT
Q9NYF8 S320 Sugiyama BCLAF1 BTF KIAA0164 sPAKtIAPQNAPRDEsRGRssFyPDGGDQETAKtGKFLKRF
Q9NYV4 S1053 Sugiyama CDK12 CRK7 CRKRS KIAA0904 LPHWQDCHELWSKKRRRQRQsGVVVEEPPPSKTSRKETtsG
Q9UBK8 S226 Sugiyama MTRR VLKQNAVNSNQSNVVIEDFEsSLTRSVPPLSQASLNIPGLP
Q9UBP6 S27 Sugiyama METTL1 C12orf1 NVAGAEAPPPQKRYYRQRAHsNPMADHTLRYPVKPEEMDWS
Q9UGV2 S327 Sugiyama NDRG3 KYFLQGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsV
Q9UGV2 S331 Sugiyama NDRG3 QGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQ
Q9UHD1 S200 Sugiyama CHORDC1 CHP1 SGVPIFHEGMKYWSCCRRKtsDFNtFLAQEGCtKGKHMWTK
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UKJ3 S890 Sugiyama GPATCH8 GPATC8 KIAA0553 YSSSSDASSDQSCYSRQRSYsDDSYSDYSDRSRRHSKRSHD
Q9UKV8 S387 Sugiyama AGO2 EIF2C2 ATARSAPDRQEEISKLMRsAsFNTDPyVREFGIMVKDEMTD
Q9UL51 S668 SIGNOR HCN2 BCNG2 MRRAFETVAIDRLDRIGKKNsILLHKVQHDLNSGVFNNQEN
Q9ULL1 S611 Sugiyama PLEKHG1 KIAA1209 GQMESTETSSSGHRIVRRAssAGEsNtCPPEIGTSDRTREL
Q9UN37 S430 Sugiyama VPS4A VPS4 SLATTRPTVNADDLLKVKKFsEDFGQES_____________
Q9UNH7 S316 Sugiyama SNX6 LKYYLRESQAAKDLLYRRsRsLVDYENANKALDKARAKNKD
Q9UPQ0 S377 Sugiyama LIMCH1 KIAA1102 LREEDDKWQDDLARWKSRRRsVsQDLIKKEEERKKMEKLLA
Q9UQ35 S1455 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 PsRRsRsGssPGLRDGsGtPsRHsLsGssPGMKDIPRtPSR
Q9UQ35 S1539 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sEssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEs
Q9UQ35 S1541 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDs
Q9UQ35 S1542 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDss
Q9UQ35 S2692 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9UQ80 S267 Sugiyama PA2G4 EBP1 YKRDPSKQYGLKMKtSRAFFsEVERRFDAMPFtLRAFEDEK
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2I7 S307 Sugiyama PIKFYVE KIAA0981 PIP5K3 TRLVSVQEDAGKsPARNRsAsItNLsLDRsGsPMVPSYEts
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 1.914979e-10 9.718 0 0
Cell Cycle, Mitotic R-HSA-69278 5.780704e-08 7.238 0 0
Signal Transduction R-HSA-162582 2.816236e-07 6.550 1 0
Axon guidance R-HSA-422475 1.053449e-06 5.977 0 0
Nervous system development R-HSA-9675108 1.065273e-06 5.973 0 0
HSF1-dependent transactivation R-HSA-3371571 1.679816e-06 5.775 0 0
NRAGE signals death through JNK R-HSA-193648 2.087015e-06 5.680 0 0
Chromatin modifying enzymes R-HSA-3247509 3.342469e-06 5.476 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 5.185433e-06 5.285 0 0
G alpha (12/13) signalling events R-HSA-416482 5.644164e-06 5.248 0 0
Mitotic Prometaphase R-HSA-68877 8.800065e-06 5.056 0 0
Chromatin organization R-HSA-4839726 9.824177e-06 5.008 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.108232e-05 4.955 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.108232e-05 4.955 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.356264e-05 4.868 0 0
Cell Cycle Checkpoints R-HSA-69620 1.399998e-05 4.854 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.426629e-05 4.846 0 0
Apoptotic execution phase R-HSA-75153 1.400708e-05 4.854 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.683334e-05 4.774 0 0
Attenuation phase R-HSA-3371568 2.099570e-05 4.678 0 0
Rap1 signalling R-HSA-392517 2.308624e-05 4.637 0 0
M Phase R-HSA-68886 2.564279e-05 4.591 0 0
Activation of RAC1 R-HSA-428540 3.658359e-05 4.437 0 0
Mitotic Spindle Checkpoint R-HSA-69618 4.015137e-05 4.396 0 0
Signaling by ROBO receptors R-HSA-376176 5.588514e-05 4.253 0 0
Oncogenic MAPK signaling R-HSA-6802957 5.750945e-05 4.240 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 7.500550e-05 4.125 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 7.826588e-05 4.106 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 7.866736e-05 4.104 0 0
Post NMDA receptor activation events R-HSA-438064 9.714000e-05 4.013 0 0
Separation of Sister Chromatids R-HSA-2467813 1.016893e-04 3.993 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.276970e-04 3.894 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.329646e-04 3.876 0 0
Cellular response to heat stress R-HSA-3371556 1.399925e-04 3.854 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.906842e-04 3.720 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.010975e-04 3.697 0 0
Meiotic synapsis R-HSA-1221632 2.131767e-04 3.671 0 0
Death Receptor Signaling R-HSA-73887 2.276197e-04 3.643 0 0
HSF1 activation R-HSA-3371511 2.278607e-04 3.642 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.597076e-04 3.586 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.867383e-04 3.413 0 0
Mitotic Anaphase R-HSA-68882 4.202327e-04 3.377 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 4.610164e-04 3.336 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 4.757133e-04 3.323 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 5.471149e-04 3.262 0 0
Semaphorin interactions R-HSA-373755 5.684422e-04 3.245 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 5.798574e-04 3.237 0 0
RMTs methylate histone arginines R-HSA-3214858 6.298418e-04 3.201 0 0
Cellular Senescence R-HSA-2559583 6.418044e-04 3.193 0 0
Meiosis R-HSA-1500620 7.096150e-04 3.149 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 9.440084e-04 3.025 0 0
Signaling downstream of RAS mutants R-HSA-9649948 9.440084e-04 3.025 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 9.440084e-04 3.025 0 0
Signaling by RAS mutants R-HSA-6802949 9.440084e-04 3.025 0 0
HDMs demethylate histones R-HSA-3214842 9.441216e-04 3.025 0 0
Sema4D in semaphorin signaling R-HSA-400685 9.441216e-04 3.025 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.206702e-03 2.918 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 1.248237e-03 2.904 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.305065e-03 2.884 0 0
Diseases of programmed cell death R-HSA-9645723 1.256185e-03 2.901 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.773567e-03 2.751 0 0
Kinesins R-HSA-983189 1.907451e-03 2.720 0 0
G2/M Transition R-HSA-69275 1.952017e-03 2.710 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.200158e-03 2.658 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.312013e-03 2.636 0 0
Ion homeostasis R-HSA-5578775 2.305711e-03 2.637 0 0
Neurodegenerative Diseases R-HSA-8863678 2.286459e-03 2.641 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.286459e-03 2.641 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.320999e-03 2.634 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.368225e-03 2.626 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.609760e-03 2.583 0 0
Regulation of TP53 Activity R-HSA-5633007 2.578365e-03 2.589 0 0
MAPK family signaling cascades R-HSA-5683057 2.820249e-03 2.550 1 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 3.167204e-03 2.499 0 0
Apoptosis R-HSA-109581 3.090690e-03 2.510 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.280591e-03 2.484 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.301999e-03 2.481 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.495645e-03 2.456 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 3.342465e-03 2.476 0 0
Cardiac conduction R-HSA-5576891 4.043364e-03 2.393 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 4.260531e-03 2.371 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 4.280729e-03 2.368 0 0
HDACs deacetylate histones R-HSA-3214815 4.486829e-03 2.348 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 4.527811e-03 2.344 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.627285e-03 2.335 0 0
AURKA Activation by TPX2 R-HSA-8854518 4.671669e-03 2.331 0 0
EPH-Ephrin signaling R-HSA-2682334 4.764960e-03 2.322 0 0
RET signaling R-HSA-8853659 4.925544e-03 2.308 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 5.578047e-03 2.254 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 5.377577e-03 2.269 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 5.713940e-03 2.243 0 0
MAP2K and MAPK activation R-HSA-5674135 5.831498e-03 2.234 0 0
FOXO-mediated transcription R-HSA-9614085 6.128907e-03 2.213 0 0
HATs acetylate histones R-HSA-3214847 6.128907e-03 2.213 0 0
Protein-protein interactions at synapses R-HSA-6794362 6.282488e-03 2.202 0 0
Muscle contraction R-HSA-397014 6.252754e-03 2.204 0 0
Programmed Cell Death R-HSA-5357801 5.938306e-03 2.226 0 0
Neurexins and neuroligins R-HSA-6794361 6.355469e-03 2.197 0 0
RAF/MAP kinase cascade R-HSA-5673001 6.364240e-03 2.196 1 0
Regulation of NFE2L2 gene expression R-HSA-9818749 6.913760e-03 2.160 0 0
DARPP-32 events R-HSA-180024 7.036100e-03 2.153 0 0
Breakdown of the nuclear lamina R-HSA-352238 7.351029e-03 2.134 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 7.520148e-03 2.124 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 7.057425e-03 2.151 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 8.259841e-03 2.083 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 8.274393e-03 2.082 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 8.968864e-03 2.047 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.006134e-02 1.997 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 9.854495e-03 2.006 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.007007e-02 1.997 0 0
Intracellular signaling by second messengers R-HSA-9006925 9.625251e-03 2.017 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 9.678390e-03 2.014 1 0
TRP channels R-HSA-3295583 1.025426e-02 1.989 0 0
Metalloprotease DUBs R-HSA-5689901 1.025426e-02 1.989 0 0
Reproduction R-HSA-1474165 1.105938e-02 1.956 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.139764e-02 1.943 0 0
Ephrin signaling R-HSA-3928664 1.149620e-02 1.939 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.156787e-02 1.937 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.203764e-02 1.919 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.274339e-02 1.895 0 0
Neuronal System R-HSA-112316 1.296275e-02 1.887 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.317683e-02 1.880 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.317683e-02 1.880 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.341223e-02 1.872 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.341223e-02 1.872 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.351865e-02 1.869 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.383933e-02 1.859 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.464254e-02 1.834 0 0
Germ layer formation at gastrulation R-HSA-9754189 1.447385e-02 1.839 0 0
Centrosome maturation R-HSA-380287 1.432268e-02 1.844 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.468915e-02 1.833 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.468915e-02 1.833 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.482208e-02 1.829 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.489255e-02 1.827 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.501019e-02 1.824 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.624841e-02 1.789 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.693006e-02 1.771 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.703331e-02 1.769 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.717160e-02 1.765 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.939222e-02 1.712 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.939222e-02 1.712 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.939222e-02 1.712 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.939222e-02 1.712 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.939222e-02 1.712 0 0
DNA methylation R-HSA-5334118 1.793222e-02 1.746 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.813497e-02 1.741 0 0
Signaling by VEGF R-HSA-194138 1.870378e-02 1.728 0 0
Gene expression (Transcription) R-HSA-74160 1.982273e-02 1.703 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 2.136302e-02 1.670 0 0
RAF activation R-HSA-5673000 2.031054e-02 1.692 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.070591e-02 1.684 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.171185e-02 1.663 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.993628e-02 1.700 0 0
Netrin-1 signaling R-HSA-373752 2.070591e-02 1.684 0 0
Long-term potentiation R-HSA-9620244 2.189542e-02 1.660 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.132660e-02 1.671 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 2.031054e-02 1.692 0 0
Autophagy R-HSA-9612973 2.255339e-02 1.647 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.365201e-02 1.626 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 2.366118e-02 1.626 0 0
Nucleosome assembly R-HSA-774815 2.366118e-02 1.626 0 0
DAG and IP3 signaling R-HSA-1489509 2.366118e-02 1.626 0 0
Trafficking of AMPA receptors R-HSA-399719 2.499050e-02 1.602 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 2.509526e-02 1.600 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.835657e-02 1.547 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.835657e-02 1.547 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.835657e-02 1.547 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.835657e-02 1.547 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.835657e-02 1.547 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.835657e-02 1.547 0 0
mRNA 3'-end processing R-HSA-72187 2.794642e-02 1.554 0 0
Calmodulin induced events R-HSA-111933 2.737711e-02 1.563 0 0
CaM pathway R-HSA-111997 2.737711e-02 1.563 0 0
Macroautophagy R-HSA-1632852 2.811926e-02 1.551 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.672746e-02 1.573 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.608430e-02 1.584 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.672746e-02 1.573 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.589572e-02 1.587 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.870333e-02 1.542 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.917514e-02 1.535 0 0
Chaperone Mediated Autophagy R-HSA-9613829 3.258817e-02 1.487 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 3.258817e-02 1.487 0 0
Interaction between L1 and Ankyrins R-HSA-445095 3.080979e-02 1.511 0 0
Packaging Of Telomere Ends R-HSA-171306 3.080979e-02 1.511 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.385113e-02 1.470 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.150694e-02 1.502 0 0
Synaptic adhesion-like molecules R-HSA-8849932 3.258817e-02 1.487 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 3.249208e-02 1.488 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 3.385113e-02 1.470 0 0
Mitotic Prophase R-HSA-68875 3.112207e-02 1.507 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 3.155971e-02 1.501 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 3.155971e-02 1.501 0 0
Cell junction organization R-HSA-446728 3.133507e-02 1.504 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.564705e-02 1.448 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 3.584905e-02 1.446 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 3.606132e-02 1.443 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 3.610037e-02 1.442 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 3.751831e-02 1.426 0 0
Signaling by APC mutants R-HSA-4839744 3.751831e-02 1.426 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 3.751831e-02 1.426 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 3.751831e-02 1.426 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 3.751831e-02 1.426 0 0
Defective pyroptosis R-HSA-9710421 3.761399e-02 1.425 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.807909e-02 1.419 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.956591e-02 1.403 0 0
PLC beta mediated events R-HSA-112043 3.956591e-02 1.403 0 0
RNA Polymerase II Transcription R-HSA-73857 3.958308e-02 1.402 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 3.961579e-02 1.402 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.961579e-02 1.402 0 0
Cell-extracellular matrix interactions R-HSA-446353 3.961579e-02 1.402 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 4.277130e-02 1.369 0 0
Regulation of PTEN localization R-HSA-8948747 4.277130e-02 1.369 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 4.277130e-02 1.369 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 4.715889e-02 1.326 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 4.715889e-02 1.326 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 4.651526e-02 1.332 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 4.651526e-02 1.332 0 0
Formation of definitive endoderm R-HSA-9823730 4.715889e-02 1.326 0 0
Aggrephagy R-HSA-9646399 4.651526e-02 1.332 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.433072e-02 1.353 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.433072e-02 1.353 0 0
Dopamine receptors R-HSA-390651 4.433072e-02 1.353 0 0
Ub-specific processing proteases R-HSA-5689880 4.679141e-02 1.330 0 0
MECP2 regulates transcription factors R-HSA-9022707 4.277130e-02 1.369 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.479360e-02 1.349 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.764119e-02 1.322 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 4.782315e-02 1.320 0 0
Signaling by AMER1 mutants R-HSA-4839748 4.782315e-02 1.320 0 0
Signaling by AXIN mutants R-HSA-4839735 4.782315e-02 1.320 0 0
Meiotic recombination R-HSA-912446 4.823963e-02 1.317 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.843195e-02 1.315 0 0
Interleukin-37 signaling R-HSA-9008059 4.847535e-02 1.314 0 0
Phase 4 - resting membrane potential R-HSA-5576886 4.852784e-02 1.314 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 4.852784e-02 1.314 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 4.934375e-02 1.307 0 0
Cellular responses to stress R-HSA-2262752 4.996519e-02 1.301 0 0
PIP3 activates AKT signaling R-HSA-1257604 5.049966e-02 1.297 0 0
Cell-Cell communication R-HSA-1500931 5.135273e-02 1.289 0 0
Interleukin-12 signaling R-HSA-9020591 5.177166e-02 1.286 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 5.225344e-02 1.282 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 5.225344e-02 1.282 0 0
Tight junction interactions R-HSA-420029 5.225344e-02 1.282 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 5.244615e-02 1.280 0 0
FLT3 Signaling R-HSA-9607240 5.244615e-02 1.280 0 0
Chromosome Maintenance R-HSA-73886 5.278667e-02 1.277 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 5.281783e-02 1.277 0 0
Selective autophagy R-HSA-9663891 5.405399e-02 1.267 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 5.866012e-02 1.232 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 5.866012e-02 1.232 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 6.415641e-02 1.193 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 6.415641e-02 1.193 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 6.415641e-02 1.193 0 0
Hedgehog 'off' state R-HSA-5610787 5.969124e-02 1.224 0 0
Adrenoceptors R-HSA-390696 5.675478e-02 1.246 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 5.675478e-02 1.246 0 0
Negative regulation of MAPK pathway R-HSA-5675221 5.886387e-02 1.230 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 5.825243e-02 1.235 0 0
Cellular responses to stimuli R-HSA-8953897 6.371656e-02 1.196 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 5.964249e-02 1.224 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 5.675478e-02 1.246 0 0
NrCAM interactions R-HSA-447038 6.415641e-02 1.193 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 6.337073e-02 1.198 0 0
Regulation of PTEN gene transcription R-HSA-8943724 6.480155e-02 1.188 0 0
MTOR signalling R-HSA-165159 6.577888e-02 1.182 0 0
Ca-dependent events R-HSA-111996 6.577888e-02 1.182 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 6.577888e-02 1.182 0 0
Depyrimidination R-HSA-73928 6.577888e-02 1.182 0 0
NGF-stimulated transcription R-HSA-9031628 6.588629e-02 1.181 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 6.654261e-02 1.177 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 6.799421e-02 1.168 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 6.944822e-02 1.158 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 6.944822e-02 1.158 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 6.944822e-02 1.158 0 0
G-protein mediated events R-HSA-112040 6.966871e-02 1.157 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.978654e-02 1.156 0 0
Signaling by Hippo R-HSA-2028269 6.978654e-02 1.156 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 7.053840e-02 1.152 0 0
S Phase R-HSA-69242 7.060529e-02 1.151 0 0
Deubiquitination R-HSA-5688426 7.192189e-02 1.143 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.210585e-02 1.142 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 8.734208e-02 1.059 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 8.734208e-02 1.059 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 8.734208e-02 1.059 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 8.734208e-02 1.059 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 7.289179e-02 1.137 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 7.289179e-02 1.137 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 7.580213e-02 1.120 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 8.720065e-02 1.059 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 8.088560e-02 1.092 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 8.214278e-02 1.085 0 0
GP1b-IX-V activation signalling R-HSA-430116 7.289179e-02 1.137 0 0
Polo-like kinase mediated events R-HSA-156711 8.214278e-02 1.085 0 0
Frs2-mediated activation R-HSA-170968 7.297489e-02 1.137 0 0
Assembly of the pre-replicative complex R-HSA-68867 8.453960e-02 1.073 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 8.403577e-02 1.076 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 7.297489e-02 1.137 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 7.297489e-02 1.137 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 8.449993e-02 1.073 0 0
Signaling by WNT R-HSA-195721 7.641026e-02 1.117 1 0
Calcineurin activates NFAT R-HSA-2025928 7.289179e-02 1.137 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.088560e-02 1.092 0 0
Cell-cell junction organization R-HSA-421270 8.145519e-02 1.089 0 0
Generic Transcription Pathway R-HSA-212436 7.740242e-02 1.111 0 0
Opioid Signalling R-HSA-111885 7.887546e-02 1.103 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.289179e-02 1.137 0 0
MITF-M-dependent gene expression R-HSA-9856651 7.891369e-02 1.103 0 0
Regulation of KIT signaling R-HSA-1433559 8.779450e-02 1.057 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 8.779450e-02 1.057 0 0
cGMP effects R-HSA-418457 8.779450e-02 1.057 1 1
HDL assembly R-HSA-8963896 8.779450e-02 1.057 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.779450e-02 1.057 0 0
L1CAM interactions R-HSA-373760 8.866503e-02 1.052 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 9.047047e-02 1.043 0 0
Folding of actin by CCT/TriC R-HSA-390450 9.109540e-02 1.041 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 9.109540e-02 1.041 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 9.109540e-02 1.041 0 0
Regulation of cortical dendrite branching R-HSA-8985801 9.597335e-02 1.018 0 0
Potassium transport channels R-HSA-1296067 9.597335e-02 1.018 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 9.651437e-02 1.015 0 0
mRNA Splicing - Major Pathway R-HSA-72163 9.741420e-02 1.011 0 0
Activation of the pre-replicative complex R-HSA-68962 1.010279e-01 0.996 0 0
Signaling by NTRKs R-HSA-166520 1.015001e-01 0.994 0 0
DCC mediated attractive signaling R-HSA-418885 1.040532e-01 0.983 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.040532e-01 0.983 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.044941e-01 0.981 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.058752e-01 0.975 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.065861e-01 0.972 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.216687e-01 0.915 0 0
KIT mutants bind TKIs R-HSA-9669921 1.216687e-01 0.915 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.216687e-01 0.915 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.216687e-01 0.915 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.216687e-01 0.915 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.216687e-01 0.915 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.216687e-01 0.915 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.216687e-01 0.915 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.216687e-01 0.915 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.216687e-01 0.915 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.381436e-01 0.860 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.381436e-01 0.860 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.331644e-01 0.876 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.216834e-01 0.915 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.393939e-01 0.856 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.393939e-01 0.856 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.179958e-01 0.928 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.390973e-01 0.857 0 0
Integrin signaling R-HSA-354192 1.393939e-01 0.856 0 0
Signaling by EGFR R-HSA-177929 1.345602e-01 0.871 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.146958e-01 0.940 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.258926e-01 0.900 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.258788e-01 0.900 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.284814e-01 0.891 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.266885e-01 0.897 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.266885e-01 0.897 0 0
Prolonged ERK activation events R-HSA-169893 1.216834e-01 0.915 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.268185e-01 0.897 0 0
Signaling by WNT in cancer R-HSA-4791275 1.258788e-01 0.900 0 0
Cardiogenesis R-HSA-9733709 1.393939e-01 0.856 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.290333e-01 0.889 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.315495e-01 0.881 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.203558e-01 0.920 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.265665e-01 0.898 0 0
Formation of the nephric duct R-HSA-9830364 1.127305e-01 0.948 0 0
UCH proteinases R-HSA-5689603 1.380013e-01 0.860 0 0
G1/S-Specific Transcription R-HSA-69205 1.121200e-01 0.950 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 1.216834e-01 0.915 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.393939e-01 0.856 0 0
Interleukin-7 signaling R-HSA-1266695 1.127305e-01 0.948 0 0
Cleavage of the damaged purine R-HSA-110331 1.238320e-01 0.907 0 0
Depurination R-HSA-73927 1.361728e-01 0.866 0 0
Interleukin-12 family signaling R-HSA-447115 1.271267e-01 0.896 0 0
Glycolysis R-HSA-70171 1.400078e-01 0.854 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 1.406003e-01 0.852 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.418228e-01 0.848 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.422099e-01 0.847 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.422099e-01 0.847 0 0
Ca2+ activated K+ channels R-HSA-1296052 1.422099e-01 0.847 0 0
SOS-mediated signalling R-HSA-112412 1.422099e-01 0.847 0 0
Mitochondrial calcium ion transport R-HSA-8949215 1.425692e-01 0.846 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.438173e-01 0.842 0 0
Transmission across Chemical Synapses R-HSA-112315 1.447300e-01 0.839 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 1.473379e-01 0.832 0 0
Integration of energy metabolism R-HSA-163685 1.473742e-01 0.832 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.285403e-01 0.641 0 0
Defective ACTH causes obesity and POMCD R-HSA-5579031 2.285403e-01 0.641 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.285403e-01 0.641 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.285403e-01 0.641 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.285403e-01 0.641 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.285403e-01 0.641 0 0
Defective SLC26A4 causes Pendred syndrome (PDS) R-HSA-5619046 2.285403e-01 0.641 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.834378e-01 0.737 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.834378e-01 0.737 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.834378e-01 0.737 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.834378e-01 0.737 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 1.834378e-01 0.737 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 1.834378e-01 0.737 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 3.224137e-01 0.492 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.224137e-01 0.492 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 3.224137e-01 0.492 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 3.224137e-01 0.492 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 3.224137e-01 0.492 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.224137e-01 0.492 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 3.224137e-01 0.492 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 3.224137e-01 0.492 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 3.224137e-01 0.492 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.224137e-01 0.492 0 0
Intestinal infectious diseases R-HSA-8942233 3.224137e-01 0.492 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 3.224137e-01 0.492 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.224137e-01 0.492 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.224137e-01 0.492 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 3.224137e-01 0.492 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.224137e-01 0.492 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.224137e-01 0.492 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.224137e-01 0.492 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.224137e-01 0.492 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.224137e-01 0.492 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.304725e-01 0.637 0 0
IRS activation R-HSA-74713 2.304725e-01 0.637 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.304725e-01 0.637 0 0
Type I hemidesmosome assembly R-HSA-446107 1.730167e-01 0.762 0 0
Polymerase switching R-HSA-69091 1.566908e-01 0.805 0 0
Leading Strand Synthesis R-HSA-69109 1.566908e-01 0.805 0 0
Lipophagy R-HSA-9613354 2.054798e-01 0.687 0 0
Gap junction degradation R-HSA-190873 2.054798e-01 0.687 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.781542e-01 0.556 0 0
Signaling by MAPK mutants R-HSA-9652817 2.781542e-01 0.556 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 4.048691e-01 0.393 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.048691e-01 0.393 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 4.048691e-01 0.393 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 4.048691e-01 0.393 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 4.048691e-01 0.393 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 4.048691e-01 0.393 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 4.048691e-01 0.393 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 4.048691e-01 0.393 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 4.048691e-01 0.393 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 4.048691e-01 0.393 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 4.048691e-01 0.393 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 4.048691e-01 0.393 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 4.048691e-01 0.393 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.048691e-01 0.393 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 4.048691e-01 0.393 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.048691e-01 0.393 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.048691e-01 0.393 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 4.048691e-01 0.393 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 4.048691e-01 0.393 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 4.048691e-01 0.393 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 4.048691e-01 0.393 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.048691e-01 0.393 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 4.048691e-01 0.393 0 0
Formation of axial mesoderm R-HSA-9796292 1.816209e-01 0.741 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.816209e-01 0.741 0 0
Formation of apoptosome R-HSA-111458 2.391724e-01 0.621 0 0
Regulation of the apoptosome activity R-HSA-9627069 2.391724e-01 0.621 0 0
PI3K/AKT activation R-HSA-198203 2.391724e-01 0.621 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.391724e-01 0.621 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 2.391724e-01 0.621 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.256296e-01 0.487 0 0
CREB phosphorylation R-HSA-199920 3.256296e-01 0.487 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 3.256296e-01 0.487 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 3.256296e-01 0.487 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.256296e-01 0.487 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.256296e-01 0.487 0 0
ChREBP activates metabolic gene expression R-HSA-163765 2.736949e-01 0.563 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.736949e-01 0.563 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.348638e-01 0.629 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.040327e-01 0.690 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.739613e-01 0.760 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.980418e-01 0.703 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.270132e-01 0.644 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.270132e-01 0.644 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.270132e-01 0.644 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.270132e-01 0.644 0 0
Differentiation of T cells R-HSA-9945266 2.627577e-01 0.580 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 2.627577e-01 0.580 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 3.086800e-01 0.510 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 3.086800e-01 0.510 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 3.086800e-01 0.510 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 3.722434e-01 0.429 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.722434e-01 0.429 0 0
Netrin mediated repulsion signals R-HSA-418886 3.722434e-01 0.429 0 0
TRIF-mediated programmed cell death R-HSA-2562578 3.722434e-01 0.429 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 3.722434e-01 0.429 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 3.722434e-01 0.429 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.722434e-01 0.429 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.722434e-01 0.429 0 0
Axonal growth stimulation R-HSA-209563 4.772948e-01 0.321 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 4.772948e-01 0.321 0 0
Defective ABCA1 causes TGD R-HSA-5682113 4.772948e-01 0.321 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 4.772948e-01 0.321 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.772948e-01 0.321 0 0
Classical Kir channels R-HSA-1296053 4.772948e-01 0.321 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.772948e-01 0.321 0 0
Invadopodia formation R-HSA-8941237 4.772948e-01 0.321 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.491236e-01 0.826 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.491236e-01 0.826 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.911510e-01 0.719 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 1.911510e-01 0.719 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 2.507032e-01 0.601 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 2.912269e-01 0.536 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 2.089901e-01 0.680 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 3.437972e-01 0.464 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.437972e-01 0.464 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 2.274201e-01 0.643 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.913958e-01 0.718 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 1.913958e-01 0.718 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.628463e-01 0.788 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.600624e-01 0.585 0 0
Cristae formation R-HSA-8949613 2.600624e-01 0.585 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.200759e-01 0.495 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 4.175026e-01 0.379 0 0
Formation of annular gap junctions R-HSA-196025 4.175026e-01 0.379 0 0
FGFR1b ligand binding and activation R-HSA-190370 4.175026e-01 0.379 0 0
Activation of RAS in B cells R-HSA-1169092 4.175026e-01 0.379 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 4.175026e-01 0.379 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 4.175026e-01 0.379 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.752246e-01 0.756 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.065309e-01 0.685 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 2.817950e-01 0.550 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.787537e-01 0.422 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 3.787537e-01 0.422 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 3.491203e-01 0.457 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.247552e-01 0.488 0 0
Late endosomal microautophagy R-HSA-9615710 3.039101e-01 0.517 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.039101e-01 0.517 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.948307e-01 0.710 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.856281e-01 0.544 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.856281e-01 0.544 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 2.566461e-01 0.591 0 0
NRIF signals cell death from the nucleus R-HSA-205043 4.132947e-01 0.384 0 0
Removal of the Flap Intermediate R-HSA-69166 4.132947e-01 0.384 0 0
HCN channels R-HSA-1296061 5.409101e-01 0.267 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.409101e-01 0.267 0 0
MPS VI - Maroteaux-Lamy syndrome R-HSA-2206285 5.409101e-01 0.267 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 5.409101e-01 0.267 0 0
ATP sensitive Potassium channels R-HSA-1296025 5.409101e-01 0.267 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.409101e-01 0.267 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.724335e-01 0.565 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 3.062637e-01 0.514 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 3.753769e-01 0.426 0 0
Co-inhibition by CTLA4 R-HSA-389513 4.071219e-01 0.390 0 0
Spry regulation of FGF signaling R-HSA-1295596 4.472024e-01 0.349 0 0
Erythropoietin activates RAS R-HSA-9027284 4.472024e-01 0.349 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 4.472024e-01 0.349 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.711446e-01 0.567 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 2.112221e-01 0.675 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 2.112221e-01 0.675 0 0
mRNA Splicing R-HSA-72172 1.546085e-01 0.811 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 5.026231e-01 0.299 0 0
DNA replication initiation R-HSA-68952 5.026231e-01 0.299 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.884630e-01 0.411 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 4.259435e-01 0.371 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 4.259435e-01 0.371 0 0
Nuclear Receptor transcription pathway R-HSA-383280 3.282997e-01 0.484 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 3.827191e-01 0.417 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 3.827191e-01 0.417 0 0
Orc1 removal from chromatin R-HSA-68949 3.772255e-01 0.423 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 4.172217e-01 0.380 0 0
Phosphorylation of the APC/C R-HSA-176412 4.802936e-01 0.318 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 4.802936e-01 0.318 0 0
Metabolism of non-coding RNA R-HSA-194441 3.719641e-01 0.429 0 0
snRNP Assembly R-HSA-191859 3.719641e-01 0.429 0 0
HIV Transcription Elongation R-HSA-167169 4.093263e-01 0.388 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.093263e-01 0.388 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.093263e-01 0.388 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 3.350775e-01 0.475 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 4.640277e-01 0.333 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 4.509558e-01 0.346 0 0
HIV elongation arrest and recovery R-HSA-167287 4.509558e-01 0.346 0 0
Pausing and recovery of HIV elongation R-HSA-167290 4.509558e-01 0.346 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.483938e-01 0.458 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.483938e-01 0.458 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.155815e-01 0.381 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 4.756691e-01 0.323 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 5.124182e-01 0.290 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 5.124182e-01 0.290 0 0
Phase 2 - plateau phase R-HSA-5576893 5.124182e-01 0.290 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 5.124182e-01 0.290 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 5.124182e-01 0.290 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 4.845797e-01 0.315 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 4.845797e-01 0.315 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 5.000050e-01 0.301 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 5.000050e-01 0.301 0 0
Regulation of RAS by GAPs R-HSA-5658442 4.790400e-01 0.320 0 0
Voltage gated Potassium channels R-HSA-1296072 5.065198e-01 0.295 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 5.434558e-01 0.265 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 5.238929e-01 0.281 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 5.238929e-01 0.281 0 0
HCMV Early Events R-HSA-9609690 4.417467e-01 0.355 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 4.900325e-01 0.310 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 5.452817e-01 0.263 0 0
Deadenylation of mRNA R-HSA-429947 5.452817e-01 0.263 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.792784e-01 0.237 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 5.792784e-01 0.237 0 0
ERKs are inactivated R-HSA-202670 5.792784e-01 0.237 0 0
Formation of a pool of free 40S subunits R-HSA-72689 5.092216e-01 0.293 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 5.733132e-01 0.242 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 5.513266e-01 0.259 0 0
Translation initiation complex formation R-HSA-72649 5.533180e-01 0.257 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 5.571701e-01 0.254 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 5.700839e-01 0.244 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 5.700550e-01 0.244 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 5.721026e-01 0.243 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 5.742130e-01 0.241 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.887627e-01 0.230 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 5.887627e-01 0.230 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.444154e-01 0.612 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.060581e-01 0.514 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 2.112221e-01 0.675 0 0
PKR-mediated signaling R-HSA-9833482 1.773260e-01 0.751 0 0
RNA Polymerase III Transcription R-HSA-74158 4.845797e-01 0.315 0 0
EGFR downregulation R-HSA-182971 3.489381e-01 0.457 0 0
Regulation of necroptotic cell death R-HSA-5675482 5.700839e-01 0.244 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 4.168921e-01 0.380 0 0
Adipogenesis R-HSA-9843745 5.373212e-01 0.270 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 5.700839e-01 0.244 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 5.922862e-01 0.227 0 0
Signaling by SCF-KIT R-HSA-1433557 2.221337e-01 0.653 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.658035e-01 0.575 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.818380e-01 0.550 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 5.000050e-01 0.301 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.463791e-01 0.608 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 3.247552e-01 0.488 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 3.468458e-01 0.460 0 0
Lagging Strand Synthesis R-HSA-69186 4.357778e-01 0.361 0 0
Telomere Extension By Telomerase R-HSA-171319 4.509558e-01 0.346 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 5.032900e-01 0.298 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.118997e-01 0.674 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 3.437972e-01 0.464 0 0
G0 and Early G1 R-HSA-1538133 2.274201e-01 0.643 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.545962e-01 0.594 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 2.897073e-01 0.538 0 0
Telomere Maintenance R-HSA-157579 1.728333e-01 0.762 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 4.508725e-01 0.346 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.451627e-01 0.611 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.725899e-01 0.564 0 0
Regulation of CDH1 Function R-HSA-9764561 4.676857e-01 0.330 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 2.193853e-01 0.659 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.057872e-01 0.515 0 0
Processive synthesis on the lagging strand R-HSA-69183 4.472024e-01 0.349 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 4.163945e-01 0.380 0 0
Extension of Telomeres R-HSA-180786 5.032900e-01 0.298 0 0
ESR-mediated signaling R-HSA-8939211 2.839079e-01 0.547 0 0
Signaling by ERBB2 R-HSA-1227986 3.890324e-01 0.410 0 0
p75NTR signals via NF-kB R-HSA-193639 4.472024e-01 0.349 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 4.496895e-01 0.347 0 0
Nucleotide Excision Repair R-HSA-5696398 5.529114e-01 0.257 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 2.054798e-01 0.687 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 2.391724e-01 0.621 0 0
DNA Double-Strand Break Repair R-HSA-5693532 3.012808e-01 0.521 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 3.165588e-01 0.500 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.720156e-01 0.565 0 0
GAB1 signalosome R-HSA-180292 3.491203e-01 0.457 0 0
Homology Directed Repair R-HSA-5693538 2.023514e-01 0.694 0 0
Synthesis of DNA R-HSA-69239 4.768033e-01 0.322 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 2.180983e-01 0.661 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 2.054798e-01 0.687 0 0
Formation of lateral plate mesoderm R-HSA-9758920 2.781542e-01 0.556 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.722434e-01 0.429 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 2.337804e-01 0.631 0 0
Processing of SMDT1 R-HSA-8949664 3.787537e-01 0.422 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.876424e-01 0.541 0 0
DNA strand elongation R-HSA-69190 3.716809e-01 0.430 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 4.472024e-01 0.349 0 0
Regulation of CDH11 function R-HSA-9762292 5.026231e-01 0.299 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.620623e-01 0.441 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 3.360434e-01 0.474 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 4.917583e-01 0.308 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 4.480900e-01 0.349 0 0
Regulation of mitotic cell cycle R-HSA-453276 4.480900e-01 0.349 0 0
Peptide chain elongation R-HSA-156902 4.906667e-01 0.309 0 0
G-protein beta:gamma signalling R-HSA-397795 5.700839e-01 0.244 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.451627e-01 0.611 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.684688e-01 0.773 0 0
RNA Polymerase I Transcription R-HSA-73864 3.282997e-01 0.484 0 0
Apoptotic factor-mediated response R-HSA-111471 5.733132e-01 0.242 0 0
Eukaryotic Translation Elongation R-HSA-156842 3.485138e-01 0.458 0 0
TNF signaling R-HSA-75893 5.887627e-01 0.230 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 5.141449e-01 0.289 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 1.566908e-01 0.805 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 2.054798e-01 0.687 0 0
PKA activation R-HSA-163615 1.818889e-01 0.740 0 0
Telomere C-strand synthesis initiation R-HSA-174430 2.348638e-01 0.629 0 0
Sodium/Calcium exchangers R-HSA-425561 3.086800e-01 0.510 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 4.175026e-01 0.379 0 0
p75NTR regulates axonogenesis R-HSA-193697 4.610467e-01 0.336 0 0
Regulation of gap junction activity R-HSA-191650 5.409101e-01 0.267 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.262148e-01 0.486 0 0
Potassium Channels R-HSA-1296071 2.332546e-01 0.632 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 3.165588e-01 0.500 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 2.253894e-01 0.647 0 0
NF-kB is activated and signals survival R-HSA-209560 5.792784e-01 0.237 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 5.263301e-01 0.279 0 0
Cellular response to chemical stress R-HSA-9711123 5.461878e-01 0.263 0 0
Signal attenuation R-HSA-74749 2.391724e-01 0.621 0 0
Receptor Mediated Mitophagy R-HSA-8934903 2.391724e-01 0.621 0 0
Repression of WNT target genes R-HSA-4641265 3.437972e-01 0.464 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.913958e-01 0.718 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 3.039101e-01 0.517 1 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 4.259435e-01 0.371 0 0
Generation of second messenger molecules R-HSA-202433 2.693208e-01 0.570 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 2.997843e-01 0.523 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 4.232747e-01 0.373 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 3.185368e-01 0.497 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.842297e-01 0.735 0 0
TCR signaling R-HSA-202403 2.427570e-01 0.615 0 0
DNA Replication R-HSA-69306 3.771390e-01 0.423 0 0
Sensory perception of sour taste R-HSA-9729555 1.834378e-01 0.737 0 0
Abacavir transmembrane transport R-HSA-2161517 3.256296e-01 0.487 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 2.180983e-01 0.661 0 0
Disorders of Developmental Biology R-HSA-9675151 2.912269e-01 0.536 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 4.175026e-01 0.379 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.463791e-01 0.608 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.795919e-01 0.746 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.795919e-01 0.746 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.795919e-01 0.746 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.795919e-01 0.746 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.263199e-01 0.486 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 3.781883e-01 0.422 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 4.610467e-01 0.336 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 4.093263e-01 0.388 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 5.124182e-01 0.290 0 0
Formation of the posterior neural plate R-HSA-9832991 5.420658e-01 0.266 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 4.900325e-01 0.310 0 0
MET promotes cell motility R-HSA-8875878 5.281103e-01 0.277 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 5.700839e-01 0.244 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 5.917601e-01 0.228 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.865076e-01 0.543 0 0
Triglyceride catabolism R-HSA-163560 4.845797e-01 0.315 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.463791e-01 0.608 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 4.172217e-01 0.380 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 2.348638e-01 0.629 0 0
Signaling by FGFR in disease R-HSA-1226099 4.964148e-01 0.304 0 0
Signaling by Hedgehog R-HSA-5358351 2.870062e-01 0.542 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.251331e-01 0.488 0 0
Glycogen metabolism R-HSA-8982491 4.093263e-01 0.388 0 0
Ca2+ pathway R-HSA-4086398 3.620623e-01 0.441 1 1
Platelet calcium homeostasis R-HSA-418360 1.739613e-01 0.760 0 0
Signalling to ERKs R-HSA-187687 1.839615e-01 0.735 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 5.370312e-01 0.270 0 0
DNA Repair R-HSA-73894 2.235583e-01 0.651 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 1.834378e-01 0.737 0 0
Leukotriene receptors R-HSA-391906 3.256296e-01 0.487 0 0
Specification of the neural plate border R-HSA-9834899 2.040327e-01 0.690 0 0
Pervasive developmental disorders R-HSA-9005895 3.437972e-01 0.464 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 3.437972e-01 0.464 0 0
Disorders of Nervous System Development R-HSA-9697154 3.437972e-01 0.464 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 2.166612e-01 0.664 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 4.175026e-01 0.379 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.463791e-01 0.608 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 5.026231e-01 0.299 0 0
Nuclear RNA decay R-HSA-9930044 5.700839e-01 0.244 0 0
Hedgehog 'on' state R-HSA-5632684 3.315897e-01 0.479 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 3.234474e-01 0.490 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 3.234474e-01 0.490 0 0
G1/S Transition R-HSA-69206 1.531569e-01 0.815 0 0
Signaling by NOTCH1 R-HSA-1980143 2.087711e-01 0.680 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 5.796744e-01 0.237 0 0
Developmental Biology R-HSA-1266738 1.550562e-01 0.810 0 0
Intraflagellar transport R-HSA-5620924 4.407359e-01 0.356 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.704030e-01 0.328 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 5.709197e-01 0.243 0 0
Membrane Trafficking R-HSA-199991 1.692667e-01 0.771 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 3.467660e-01 0.460 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 3.086800e-01 0.510 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 2.912269e-01 0.536 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.453472e-01 0.610 0 0
PTEN Regulation R-HSA-6807070 3.761847e-01 0.425 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 5.000050e-01 0.301 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 5.712053e-01 0.243 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.000398e-01 0.699 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.641138e-01 0.785 0 0
Cilium Assembly R-HSA-5617833 1.490846e-01 0.827 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 3.722434e-01 0.429 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 4.610467e-01 0.336 0 0
G2/M Checkpoints R-HSA-69481 1.686072e-01 0.773 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 5.452817e-01 0.263 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.288616e-01 0.640 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 4.704030e-01 0.328 0 0
Adherens junctions interactions R-HSA-418990 1.982647e-01 0.703 0 0
Response of endothelial cells to shear stress R-HSA-9860931 4.235474e-01 0.373 0 0
Inhibition of PKR R-HSA-169131 2.285403e-01 0.641 0 0
MTF1 activates gene expression R-HSA-5660489 1.834378e-01 0.737 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.224137e-01 0.492 0 0
ARMS-mediated activation R-HSA-170984 2.054798e-01 0.687 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.054798e-01 0.687 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 2.781542e-01 0.556 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 4.048691e-01 0.393 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 4.048691e-01 0.393 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.818889e-01 0.740 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 1.818889e-01 0.740 0 0
PKA activation in glucagon signalling R-HSA-164378 1.818889e-01 0.740 0 0
mTORC1-mediated signalling R-HSA-166208 1.601996e-01 0.795 0 0
Notch-HLH transcription pathway R-HSA-350054 1.601996e-01 0.795 0 0
Ionotropic activity of kainate receptors R-HSA-451306 2.736949e-01 0.563 0 0
The NLRP3 inflammasome R-HSA-844456 2.040327e-01 0.690 0 0
Protein hydroxylation R-HSA-9629569 2.270132e-01 0.644 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.722434e-01 0.429 0 0
MET interacts with TNS proteins R-HSA-8875513 4.772948e-01 0.321 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 4.772948e-01 0.321 0 0
Signaling by LTK R-HSA-9842663 3.437972e-01 0.464 0 0
Recycling pathway of L1 R-HSA-437239 1.831180e-01 0.737 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 3.200759e-01 0.495 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 3.787537e-01 0.422 0 0
E2F mediated regulation of DNA replication R-HSA-113510 3.781883e-01 0.422 0 0
Unwinding of DNA R-HSA-176974 4.610467e-01 0.336 0 0
Transmission across Electrical Synapses R-HSA-112307 5.409101e-01 0.267 0 0
Alanine metabolism R-HSA-8964540 5.409101e-01 0.267 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 5.409101e-01 0.267 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 5.026231e-01 0.299 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 5.026231e-01 0.299 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 5.026231e-01 0.299 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 4.509558e-01 0.346 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 4.398697e-01 0.357 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 5.902980e-01 0.229 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.513500e-01 0.600 0 0
Rab regulation of trafficking R-HSA-9007101 1.932750e-01 0.714 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 4.496895e-01 0.347 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 4.007190e-01 0.397 0 0
FLT3 signaling in disease R-HSA-9682385 3.262148e-01 0.486 0 0
Gap junction trafficking and regulation R-HSA-157858 3.234474e-01 0.490 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 3.034088e-01 0.518 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 5.124182e-01 0.290 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 5.731184e-01 0.242 0 0
Signaling by ERBB4 R-HSA-1236394 2.720156e-01 0.565 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 5.700550e-01 0.244 0 0
Interleukin-2 family signaling R-HSA-451927 5.700550e-01 0.244 0 0
Heme signaling R-HSA-9707616 4.232747e-01 0.373 0 0
Smooth Muscle Contraction R-HSA-445355 2.724335e-01 0.565 0 0
Downstream signal transduction R-HSA-186763 3.489381e-01 0.457 0 0
ISG15 antiviral mechanism R-HSA-1169408 5.123074e-01 0.290 0 0
Signaling by TGFBR3 R-HSA-9839373 2.713789e-01 0.566 0 0
Interleukin-1 family signaling R-HSA-446652 3.665196e-01 0.436 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.403838e-01 0.356 0 0
Signaling by PTK6 R-HSA-8848021 4.403838e-01 0.356 0 0
Adaptive Immune System R-HSA-1280218 4.920849e-01 0.308 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.500749e-01 0.456 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.391724e-01 0.621 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 4.175026e-01 0.379 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.997001e-01 0.523 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 5.124182e-01 0.290 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 5.676548e-01 0.246 0 0
Regulation of insulin secretion R-HSA-422356 2.557858e-01 0.592 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 3.491203e-01 0.457 0 0
Amine ligand-binding receptors R-HSA-375280 2.381680e-01 0.623 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 2.304725e-01 0.637 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.816209e-01 0.741 0 0
Nef and signal transduction R-HSA-164944 3.256296e-01 0.487 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 2.997001e-01 0.523 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 3.787537e-01 0.422 0 0
Interleukin-1 processing R-HSA-448706 4.610467e-01 0.336 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 4.610467e-01 0.336 0 0
Regulated proteolysis of p75NTR R-HSA-193692 4.610467e-01 0.336 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.610467e-01 0.336 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.451627e-01 0.611 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 4.472024e-01 0.349 0 0
Gap junction trafficking R-HSA-190828 3.634113e-01 0.440 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 3.250189e-01 0.488 0 0
LGI-ADAM interactions R-HSA-5682910 5.420658e-01 0.266 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 5.420658e-01 0.266 0 0
Syndecan interactions R-HSA-3000170 5.188710e-01 0.285 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 5.318046e-01 0.274 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 5.922862e-01 0.227 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.903283e-01 0.229 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.795919e-01 0.746 0 0
MHC class II antigen presentation R-HSA-2132295 3.286016e-01 0.483 0 0
TGFBR3 expression R-HSA-9839394 3.753769e-01 0.426 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 4.007190e-01 0.397 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 2.658035e-01 0.575 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.782144e-01 0.422 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.818889e-01 0.740 0 0
Signaling by ALK R-HSA-201556 2.513500e-01 0.600 0 0
TBC/RABGAPs R-HSA-8854214 4.918248e-01 0.308 0 0
Platelet homeostasis R-HSA-418346 5.660093e-01 0.247 1 0
Glucose metabolism R-HSA-70326 2.625459e-01 0.581 0 0
Uptake and function of anthrax toxins R-HSA-5210891 5.434558e-01 0.265 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.574431e-01 0.340 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 5.092410e-01 0.293 0 0
Signaling by ALK in cancer R-HSA-9700206 3.782144e-01 0.422 0 0
PI Metabolism R-HSA-1483255 3.969221e-01 0.401 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.781542e-01 0.556 0 0
DSCAM interactions R-HSA-376172 4.048691e-01 0.393 0 0
Tandem pore domain potassium channels R-HSA-1296346 2.391724e-01 0.621 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.772948e-01 0.321 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 2.065309e-01 0.685 0 0
Transport of connexons to the plasma membrane R-HSA-190872 3.491203e-01 0.457 0 0
Cellular response to mitochondrial stress R-HSA-9840373 4.610467e-01 0.336 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 5.409101e-01 0.267 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.944678e-01 0.404 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 4.357778e-01 0.361 0 0
LTC4-CYSLTR mediated IL4 production R-HSA-9664535 5.026231e-01 0.299 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 5.026231e-01 0.299 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 5.026231e-01 0.299 0 0
Negative regulation of FLT3 R-HSA-9706369 4.802936e-01 0.318 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 4.802936e-01 0.318 0 0
Synthesis of PI R-HSA-1483226 5.420658e-01 0.266 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 5.452817e-01 0.263 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 5.792784e-01 0.237 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 5.493030e-01 0.260 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 5.768639e-01 0.239 0 0
Diseases of DNA repair R-HSA-9675135 4.020739e-01 0.396 0 0
Inflammasomes R-HSA-622312 4.509558e-01 0.346 0 0
Co-stimulation by CD28 R-HSA-389356 1.970020e-01 0.706 0 0
Activation of BH3-only proteins R-HSA-114452 3.263199e-01 0.486 0 0
Plasma lipoprotein assembly R-HSA-8963898 3.500193e-01 0.456 0 0
Stimuli-sensing channels R-HSA-2672351 3.003883e-01 0.522 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 4.407359e-01 0.356 0 0
Sensory processing of sound R-HSA-9659379 2.454275e-01 0.610 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.491236e-01 0.826 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.730167e-01 0.762 0 0
Base Excision Repair R-HSA-73884 3.085834e-01 0.511 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 3.256296e-01 0.487 0 0
Histamine receptors R-HSA-390650 4.772948e-01 0.321 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.948307e-01 0.710 0 0
PECAM1 interactions R-HSA-210990 5.420658e-01 0.266 0 0
Cytokine Signaling in Immune system R-HSA-1280215 3.778756e-01 0.423 0 0
Formation of the anterior neural plate R-HSA-9823739 4.472024e-01 0.349 0 0
Specification of primordial germ cells R-HSA-9827857 1.607053e-01 0.794 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.722434e-01 0.429 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 3.722434e-01 0.429 0 0
Interleukin-18 signaling R-HSA-9012546 4.175026e-01 0.379 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 5.409101e-01 0.267 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 5.409101e-01 0.267 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 3.213750e-01 0.493 0 0
Passive transport by Aquaporins R-HSA-432047 5.124182e-01 0.290 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.188710e-01 0.285 0 0
Signaling by Interleukins R-HSA-449147 2.253515e-01 0.647 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.880360e-01 0.726 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.781542e-01 0.556 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 4.472024e-01 0.349 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 4.172217e-01 0.380 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 5.420658e-01 0.266 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 4.777293e-01 0.321 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.491203e-01 0.457 0 0
CD28 dependent Vav1 pathway R-HSA-389359 3.787537e-01 0.422 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 5.922862e-01 0.227 0 0
SARS-CoV-1 Infection R-HSA-9678108 4.604451e-01 0.337 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 4.640277e-01 0.333 0 0
Platelet sensitization by LDL R-HSA-432142 5.733132e-01 0.242 0 0
Signaling by Leptin R-HSA-2586552 5.026231e-01 0.299 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 5.733132e-01 0.242 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 5.957272e-01 0.225 0 0
Activation of AMPA receptors R-HSA-399710 5.967865e-01 0.224 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 5.967865e-01 0.224 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 5.967865e-01 0.224 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.967865e-01 0.224 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 5.967865e-01 0.224 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.967865e-01 0.224 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.967865e-01 0.224 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 5.967865e-01 0.224 0 0
Defective F9 activation R-HSA-9673221 5.967865e-01 0.224 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.967865e-01 0.224 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.967865e-01 0.224 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.967865e-01 0.224 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.967865e-01 0.224 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 5.967865e-01 0.224 0 0
PTK6 Down-Regulation R-HSA-8849472 5.967865e-01 0.224 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.019217e-01 0.220 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.019217e-01 0.220 0 0
STING mediated induction of host immune responses R-HSA-1834941 6.019217e-01 0.220 0 0
Amyloid fiber formation R-HSA-977225 6.039013e-01 0.219 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 6.064357e-01 0.217 1 0
Degradation of CDH1 R-HSA-9766229 6.076108e-01 0.216 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.100900e-01 0.215 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 6.138382e-01 0.212 0 0
Mitophagy R-HSA-5205647 6.138382e-01 0.212 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.138382e-01 0.212 0 0
NOD1/2 Signaling Pathway R-HSA-168638 6.138382e-01 0.212 0 0
Nuclear import of Rev protein R-HSA-180746 6.138382e-01 0.212 0 0
Gap junction assembly R-HSA-190861 6.138382e-01 0.212 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 6.142194e-01 0.212 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 6.142194e-01 0.212 0 0
GRB2 events in EGFR signaling R-HSA-179812 6.142194e-01 0.212 0 0
p75NTR recruits signalling complexes R-HSA-209543 6.142194e-01 0.212 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 6.142194e-01 0.212 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 6.142194e-01 0.212 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 6.142194e-01 0.212 0 0
Estrogen biosynthesis R-HSA-193144 6.142194e-01 0.212 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 6.142194e-01 0.212 0 0
Interleukin-15 signaling R-HSA-8983432 6.142194e-01 0.212 0 0
OAS antiviral response R-HSA-8983711 6.142194e-01 0.212 0 0
Cap-dependent Translation Initiation R-HSA-72737 6.168724e-01 0.210 0 0
Eukaryotic Translation Initiation R-HSA-72613 6.168724e-01 0.210 0 0
Host Interactions of HIV factors R-HSA-162909 6.170060e-01 0.210 0 0
Eukaryotic Translation Termination R-HSA-72764 6.172097e-01 0.210 0 0
Signaling by NOTCH4 R-HSA-9013694 6.193909e-01 0.208 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 6.196583e-01 0.208 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 6.196583e-01 0.208 0 0
Neutrophil degranulation R-HSA-6798695 6.199298e-01 0.208 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 6.227942e-01 0.206 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 6.227942e-01 0.206 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.292341e-01 0.201 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.292341e-01 0.201 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 6.292341e-01 0.201 0 0
Signaling by NODAL R-HSA-1181150 6.292341e-01 0.201 0 0
Nephrin family interactions R-HSA-373753 6.292341e-01 0.201 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 6.347080e-01 0.197 0 0
Regulation of Apoptosis R-HSA-169911 6.347080e-01 0.197 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 6.347080e-01 0.197 0 0
DNA Double Strand Break Response R-HSA-5693606 6.363996e-01 0.196 0 0
Signaling by NOTCH R-HSA-157118 6.416369e-01 0.193 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 6.426785e-01 0.192 0 0
Formation of the Early Elongation Complex R-HSA-113418 6.426785e-01 0.192 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 6.426785e-01 0.192 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 6.429612e-01 0.192 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 6.446892e-01 0.191 0 0
Plus-strand DNA synthesis R-HSA-164525 6.458649e-01 0.190 0 0
PKB-mediated events R-HSA-109703 6.458649e-01 0.190 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.458649e-01 0.190 0 0
PDE3B signalling R-HSA-165160 6.458649e-01 0.190 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.458649e-01 0.190 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.458649e-01 0.190 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 6.458649e-01 0.190 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.458649e-01 0.190 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.458649e-01 0.190 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 6.458649e-01 0.190 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.458649e-01 0.190 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 6.458649e-01 0.190 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.458649e-01 0.190 0 0
Pentose phosphate pathway disease R-HSA-6791465 6.458649e-01 0.190 0 0
NGF-independant TRKA activation R-HSA-187024 6.458649e-01 0.190 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.458649e-01 0.190 0 0
Phosphorylation of Emi1 R-HSA-176417 6.458649e-01 0.190 0 0
Formation of the Editosome R-HSA-75094 6.458649e-01 0.190 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 6.458649e-01 0.190 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.458649e-01 0.190 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.458649e-01 0.190 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.458649e-01 0.190 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 6.458649e-01 0.190 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.458649e-01 0.190 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 6.458649e-01 0.190 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.458649e-01 0.190 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 6.464985e-01 0.189 0 0
Acetylcholine binding and downstream events R-HSA-181431 6.468906e-01 0.189 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 6.468906e-01 0.189 0 0
FGFR1c ligand binding and activation R-HSA-190373 6.468906e-01 0.189 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 6.468906e-01 0.189 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 6.468906e-01 0.189 0 0
Maturation of nucleoprotein R-HSA-9683610 6.468906e-01 0.189 0 0
rRNA modification in the mitochondrion R-HSA-6793080 6.468906e-01 0.189 0 0
Signaling by FGFR4 R-HSA-5654743 6.479702e-01 0.188 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 6.511470e-01 0.186 0 0
Transcription of the HIV genome R-HSA-167172 6.516238e-01 0.186 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 6.552221e-01 0.184 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 6.552221e-01 0.184 0 0
Signalling to RAS R-HSA-167044 6.552221e-01 0.184 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 6.552221e-01 0.184 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.552221e-01 0.184 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 6.559092e-01 0.183 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 6.559092e-01 0.183 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 6.559092e-01 0.183 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 6.599213e-01 0.181 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.599213e-01 0.181 0 0
Signaling by Erythropoietin R-HSA-9006335 6.647629e-01 0.177 0 0
Termination of translesion DNA synthesis R-HSA-5656169 6.647629e-01 0.177 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 6.647629e-01 0.177 0 0
Regulation of gene expression in beta cells R-HSA-210745 6.647629e-01 0.177 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 6.660462e-01 0.176 0 0
G1 Phase R-HSA-69236 6.660462e-01 0.176 0 0
Cyclin D associated events in G1 R-HSA-69231 6.660462e-01 0.176 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 6.690484e-01 0.175 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 6.708517e-01 0.173 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 6.708517e-01 0.173 0 0
MAP kinase activation R-HSA-450294 6.708517e-01 0.173 0 0
Aquaporin-mediated transport R-HSA-445717 6.708517e-01 0.173 0 0
Degradation of DVL R-HSA-4641258 6.743049e-01 0.171 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 6.743049e-01 0.171 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 6.743049e-01 0.171 0 0
Ovarian tumor domain proteases R-HSA-5689896 6.743049e-01 0.171 0 0
Ion channel transport R-HSA-983712 6.760287e-01 0.170 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 6.773268e-01 0.169 0 0
CRMPs in Sema3A signaling R-HSA-399956 6.773268e-01 0.169 0 0
Signaling by FGFR4 in disease R-HSA-5655291 6.773268e-01 0.169 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 6.773268e-01 0.169 0 0
Physiological factors R-HSA-5578768 6.773268e-01 0.169 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 6.773268e-01 0.169 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 6.781575e-01 0.169 0 0
Gene Silencing by RNA R-HSA-211000 6.781575e-01 0.169 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 6.798736e-01 0.168 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.798736e-01 0.168 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 6.798736e-01 0.168 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 6.798736e-01 0.168 0 0
Signaling by PDGFR in disease R-HSA-9671555 6.798736e-01 0.168 0 0
Signaling by FGFR3 R-HSA-5654741 6.835248e-01 0.165 0 0
Fanconi Anemia Pathway R-HSA-6783310 6.835248e-01 0.165 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 6.835248e-01 0.165 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 6.835248e-01 0.165 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 6.858962e-01 0.164 0 0
DAP12 signaling R-HSA-2424491 6.858962e-01 0.164 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 6.858962e-01 0.164 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 6.864887e-01 0.163 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.889721e-01 0.162 0 0
STAT5 Activation R-HSA-9645135 6.889721e-01 0.162 0 0
Uncoating of the HIV Virion R-HSA-162585 6.889721e-01 0.162 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.889721e-01 0.162 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.889721e-01 0.162 0 0
NADPH regeneration R-HSA-389542 6.889721e-01 0.162 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.889721e-01 0.162 0 0
Lipid particle organization R-HSA-8964572 6.889721e-01 0.162 0 0
Interleukin-1 signaling R-HSA-9020702 6.923902e-01 0.160 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 6.929993e-01 0.159 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 6.929993e-01 0.159 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 7.003949e-01 0.155 0 0
Regulation of TNFR1 signaling R-HSA-5357905 7.003949e-01 0.155 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 7.003949e-01 0.155 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 7.003949e-01 0.155 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 7.003949e-01 0.155 0 0
Signaling by KIT in disease R-HSA-9669938 7.031906e-01 0.153 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 7.031906e-01 0.153 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.031906e-01 0.153 0 0
FGFR2 alternative splicing R-HSA-6803529 7.031906e-01 0.153 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.031906e-01 0.153 0 0
Ethanol oxidation R-HSA-71384 7.031906e-01 0.153 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.031906e-01 0.153 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.031906e-01 0.153 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 7.055879e-01 0.151 0 0
SHC1 events in EGFR signaling R-HSA-180336 7.055879e-01 0.151 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 7.055879e-01 0.151 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 7.055879e-01 0.151 0 0
p38MAPK events R-HSA-171007 7.055879e-01 0.151 0 0
Biotin transport and metabolism R-HSA-196780 7.055879e-01 0.151 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 7.055879e-01 0.151 0 0
Protein methylation R-HSA-8876725 7.055879e-01 0.151 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 7.055879e-01 0.151 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 7.060709e-01 0.151 0 0
Budding and maturation of HIV virion R-HSA-162588 7.060709e-01 0.151 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 7.075159e-01 0.150 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 7.077728e-01 0.150 0 0
Stabilization of p53 R-HSA-69541 7.109450e-01 0.148 0 0
IGF1R signaling cascade R-HSA-2428924 7.150008e-01 0.146 0 0
Ion transport by P-type ATPases R-HSA-936837 7.150008e-01 0.146 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 7.166492e-01 0.145 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 7.166492e-01 0.145 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 7.166492e-01 0.145 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.226840e-01 0.141 0 0
Signaling by FGFR1 R-HSA-5654736 7.226840e-01 0.141 0 0
Circadian clock R-HSA-9909396 7.242475e-01 0.140 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.252871e-01 0.139 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 7.252871e-01 0.139 0 0
PPARA activates gene expression R-HSA-1989781 7.268142e-01 0.139 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 7.268343e-01 0.139 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 7.268343e-01 0.139 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.268343e-01 0.139 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 7.268343e-01 0.139 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 7.268343e-01 0.139 0 0
DAG1 core M1 glycosylations R-HSA-8932506 7.268343e-01 0.139 0 0
Disinhibition of SNARE formation R-HSA-114516 7.268343e-01 0.139 0 0
Recycling of eIF2:GDP R-HSA-72731 7.268343e-01 0.139 0 0
mRNA Editing: C to U Conversion R-HSA-72200 7.268343e-01 0.139 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 7.268343e-01 0.139 0 0
Activation of TRKA receptors R-HSA-187015 7.268343e-01 0.139 0 0
Glycoprotein hormones R-HSA-209822 7.268343e-01 0.139 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 7.268343e-01 0.139 0 0
CHL1 interactions R-HSA-447041 7.268343e-01 0.139 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.281385e-01 0.138 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.281385e-01 0.138 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 7.281385e-01 0.138 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 7.281385e-01 0.138 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 7.288101e-01 0.137 0 0
COPI-mediated anterograde transport R-HSA-6807878 7.306099e-01 0.136 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 7.317524e-01 0.136 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 7.317524e-01 0.136 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 7.317524e-01 0.136 0 0
Killing mechanisms R-HSA-9664420 7.317524e-01 0.136 0 0
Fructose catabolism R-HSA-70350 7.317524e-01 0.136 0 0
Regulation of BACH1 activity R-HSA-9708530 7.317524e-01 0.136 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 7.317524e-01 0.136 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 7.317524e-01 0.136 0 0
Activation of SMO R-HSA-5635838 7.317524e-01 0.136 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 7.317524e-01 0.136 0 0
GPER1 signaling R-HSA-9634597 7.322837e-01 0.135 0 0
Metal ion SLC transporters R-HSA-425410 7.322837e-01 0.135 0 0
IRS-mediated signalling R-HSA-112399 7.370673e-01 0.132 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.400289e-01 0.131 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 7.445808e-01 0.128 0 0
Maturation of spike protein R-HSA-9694548 7.445808e-01 0.128 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 7.445808e-01 0.128 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 7.445808e-01 0.128 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 7.458860e-01 0.127 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 7.458860e-01 0.127 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 7.458860e-01 0.127 0 0
TNFs bind their physiological receptors R-HSA-5669034 7.458860e-01 0.127 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 7.467698e-01 0.127 0 0
Gastrulation R-HSA-9758941 7.468345e-01 0.127 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 7.473781e-01 0.126 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 7.478087e-01 0.126 0 0
Kidney development R-HSA-9830369 7.550454e-01 0.122 0 0
Potential therapeutics for SARS R-HSA-9679191 7.555001e-01 0.122 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 7.559119e-01 0.122 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 7.559119e-01 0.122 0 0
Synthesis of PG R-HSA-1483148 7.559119e-01 0.122 0 0
Response to metal ions R-HSA-5660526 7.559119e-01 0.122 0 0
Late Phase of HIV Life Cycle R-HSA-162599 7.583306e-01 0.120 0 0
Reverse Transcription of HIV RNA R-HSA-162589 7.600894e-01 0.119 0 0
Minus-strand DNA synthesis R-HSA-164516 7.600894e-01 0.119 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.600894e-01 0.119 0 0
DAG1 core M2 glycosylations R-HSA-8932504 7.600894e-01 0.119 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.600894e-01 0.119 0 0
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597 7.600894e-01 0.119 0 0
Regulation by c-FLIP R-HSA-3371378 7.600894e-01 0.119 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.600894e-01 0.119 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.600894e-01 0.119 0 0
Dimerization of procaspase-8 R-HSA-69416 7.600894e-01 0.119 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 7.600894e-01 0.119 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.600894e-01 0.119 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 7.600894e-01 0.119 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.600894e-01 0.119 0 0
Alpha-defensins R-HSA-1462054 7.600894e-01 0.119 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.600894e-01 0.119 0 0
Sodium/Proton exchangers R-HSA-425986 7.600894e-01 0.119 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.600894e-01 0.119 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 7.602767e-01 0.119 0 0
Striated Muscle Contraction R-HSA-390522 7.608750e-01 0.119 0 0
PI3K Cascade R-HSA-109704 7.616925e-01 0.118 0 0
Triglyceride metabolism R-HSA-8979227 7.642463e-01 0.117 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.653194e-01 0.116 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.653194e-01 0.116 0 0
Co-inhibition by PD-1 R-HSA-389948 7.657317e-01 0.116 0 0
Regulated Necrosis R-HSA-5218859 7.674702e-01 0.115 0 0
Signaling by TGFB family members R-HSA-9006936 7.694071e-01 0.114 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 7.752344e-01 0.111 0 0
HCMV Infection R-HSA-9609646 7.764854e-01 0.110 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 7.772752e-01 0.109 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 7.772752e-01 0.109 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.776830e-01 0.109 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 7.781667e-01 0.109 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 7.781667e-01 0.109 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 7.781667e-01 0.109 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 7.781667e-01 0.109 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 7.781667e-01 0.109 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.781667e-01 0.109 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 7.829996e-01 0.106 0 0
Selenocysteine synthesis R-HSA-2408557 7.829996e-01 0.106 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.835253e-01 0.106 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.870715e-01 0.104 0 0
HIV Infection R-HSA-162906 7.878870e-01 0.104 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 7.886467e-01 0.103 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 7.886467e-01 0.103 0 0
Interleukin-21 signaling R-HSA-9020958 7.892977e-01 0.103 0 0
WNT mediated activation of DVL R-HSA-201688 7.892977e-01 0.103 0 0
CASP8 activity is inhibited R-HSA-5218900 7.892977e-01 0.103 0 0
ALK mutants bind TKIs R-HSA-9700645 7.892977e-01 0.103 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.892977e-01 0.103 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.892977e-01 0.103 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 7.892977e-01 0.103 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.892977e-01 0.103 0 0
mRNA Editing R-HSA-75072 7.892977e-01 0.103 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 7.892977e-01 0.103 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.892977e-01 0.103 0 0
Lysosomal oligosaccharide catabolism R-HSA-8853383 7.892977e-01 0.103 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 7.892977e-01 0.103 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.892977e-01 0.103 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 7.892977e-01 0.103 0 0
Interleukin-17 signaling R-HSA-448424 7.909427e-01 0.102 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 7.927726e-01 0.101 0 0
Chaperonin-mediated protein folding R-HSA-390466 7.958133e-01 0.099 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.961759e-01 0.099 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.961759e-01 0.099 0 0
G alpha (s) signalling events R-HSA-418555 7.971314e-01 0.098 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 7.986224e-01 0.098 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 7.986224e-01 0.098 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 7.986224e-01 0.098 0 0
FGFR1 ligand binding and activation R-HSA-190242 7.986224e-01 0.098 0 0
Presynaptic function of Kainate receptors R-HSA-500657 7.986224e-01 0.098 0 0
Mismatch Repair R-HSA-5358508 7.986224e-01 0.098 0 0
Tie2 Signaling R-HSA-210993 7.986224e-01 0.098 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 7.986224e-01 0.098 0 0
Mitochondrial biogenesis R-HSA-1592230 7.998256e-01 0.097 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.005466e-01 0.097 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.005466e-01 0.097 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.005466e-01 0.097 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.005466e-01 0.097 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.010855e-01 0.096 0 0
Signaling by PDGF R-HSA-186797 8.010855e-01 0.096 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.012217e-01 0.096 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.012217e-01 0.096 0 0
Viral mRNA Translation R-HSA-192823 8.018029e-01 0.096 0 0
Proteasome assembly R-HSA-9907900 8.029837e-01 0.095 0 0
Signaling by FGFR2 R-HSA-5654738 8.036095e-01 0.095 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 8.068914e-01 0.093 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.073913e-01 0.093 0 0
RUNX2 regulates bone development R-HSA-8941326 8.073913e-01 0.093 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 8.081097e-01 0.093 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 8.107477e-01 0.091 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 8.132088e-01 0.090 0 0
Inositol phosphate metabolism R-HSA-1483249 8.135386e-01 0.090 0 0
Binding and entry of HIV virion R-HSA-173107 8.149514e-01 0.089 0 0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 8.149514e-01 0.089 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.149514e-01 0.089 0 0
Metabolism of serotonin R-HSA-380612 8.149514e-01 0.089 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.149514e-01 0.089 0 0
Arachidonate production from DAG R-HSA-426048 8.149514e-01 0.089 0 0
Pexophagy R-HSA-9664873 8.149514e-01 0.089 0 0
Maturation of spike protein R-HSA-9683686 8.149514e-01 0.089 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 8.149514e-01 0.089 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 8.149514e-01 0.089 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.149514e-01 0.089 0 0
Peptide hormone biosynthesis R-HSA-209952 8.149514e-01 0.089 0 0
Serotonin receptors R-HSA-390666 8.149514e-01 0.089 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 8.158053e-01 0.088 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 8.158053e-01 0.088 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.164302e-01 0.088 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 8.164302e-01 0.088 0 0
Pyroptosis R-HSA-5620971 8.164302e-01 0.088 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 8.164308e-01 0.088 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 8.164308e-01 0.088 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 8.173871e-01 0.088 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 8.173871e-01 0.088 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 8.173871e-01 0.088 0 0
Maturation of nucleoprotein R-HSA-9694631 8.173871e-01 0.088 0 0
Other interleukin signaling R-HSA-449836 8.173871e-01 0.088 0 0
Cellular response to starvation R-HSA-9711097 8.177671e-01 0.087 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 8.218012e-01 0.085 0 0
Insulin receptor signalling cascade R-HSA-74751 8.230954e-01 0.085 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.279486e-01 0.082 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 8.279486e-01 0.082 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 8.312256e-01 0.080 0 0
mRNA Capping R-HSA-72086 8.312256e-01 0.080 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.312256e-01 0.080 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 8.312256e-01 0.080 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 8.312256e-01 0.080 0 0
Clathrin-mediated endocytosis R-HSA-8856828 8.324020e-01 0.080 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 8.345693e-01 0.079 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 8.345693e-01 0.079 0 0
Signal transduction by L1 R-HSA-445144 8.345693e-01 0.079 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.354703e-01 0.078 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 8.374831e-01 0.077 0 0
DAG1 core M3 glycosylations R-HSA-8932505 8.374831e-01 0.077 0 0
FGFR2b ligand binding and activation R-HSA-190377 8.374831e-01 0.077 0 0
Interleukin-2 signaling R-HSA-9020558 8.374831e-01 0.077 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 8.374831e-01 0.077 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.374831e-01 0.077 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 8.374831e-01 0.077 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 8.374831e-01 0.077 0 0
Bicarbonate transporters R-HSA-425381 8.374831e-01 0.077 0 0
Transport of RCbl within the body R-HSA-9758890 8.374831e-01 0.077 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.374831e-01 0.077 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.374831e-01 0.077 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 8.374831e-01 0.077 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 8.394047e-01 0.076 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 8.394047e-01 0.076 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.402335e-01 0.076 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 8.418233e-01 0.075 0 0
Protein ubiquitination R-HSA-8852135 8.418233e-01 0.075 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 8.449485e-01 0.073 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.449840e-01 0.073 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.449840e-01 0.073 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.462534e-01 0.072 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 8.462534e-01 0.072 0 0
Protein folding R-HSA-391251 8.498085e-01 0.071 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 8.502761e-01 0.070 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.502761e-01 0.070 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 8.502761e-01 0.070 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 8.502761e-01 0.070 0 0
ERK/MAPK targets R-HSA-198753 8.502761e-01 0.070 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 8.502761e-01 0.070 0 0
Basigin interactions R-HSA-210991 8.502761e-01 0.070 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 8.542425e-01 0.068 0 0
Dual incision in TC-NER R-HSA-6782135 8.555444e-01 0.068 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 8.572724e-01 0.067 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.572724e-01 0.067 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 8.572724e-01 0.067 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.572724e-01 0.067 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 8.572724e-01 0.067 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.572724e-01 0.067 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.572724e-01 0.067 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.572724e-01 0.067 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.572724e-01 0.067 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 8.572724e-01 0.067 0 0
Integration of provirus R-HSA-162592 8.572724e-01 0.067 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.576095e-01 0.067 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.576445e-01 0.067 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 8.577577e-01 0.067 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.577577e-01 0.067 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.577577e-01 0.067 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.577577e-01 0.067 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.577577e-01 0.067 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 8.580527e-01 0.066 0 0
Platelet activation, signaling and aggregation R-HSA-76002 8.624273e-01 0.064 0 0
Vesicle-mediated transport R-HSA-5653656 8.636519e-01 0.064 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 8.646119e-01 0.063 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.646119e-01 0.063 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 8.646119e-01 0.063 0 0
HIV Life Cycle R-HSA-162587 8.660036e-01 0.062 0 0
HCMV Late Events R-HSA-9610379 8.660036e-01 0.062 0 0
PCP/CE pathway R-HSA-4086400 8.673114e-01 0.062 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.683080e-01 0.061 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.683080e-01 0.061 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.683080e-01 0.061 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.694664e-01 0.061 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 8.695993e-01 0.061 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.701499e-01 0.060 0 0
Metabolism of RNA R-HSA-8953854 8.708683e-01 0.060 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.722440e-01 0.059 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 8.746531e-01 0.058 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 8.746531e-01 0.058 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 8.746531e-01 0.058 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.746531e-01 0.058 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.746531e-01 0.058 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.746531e-01 0.058 0 0
MET activates RAS signaling R-HSA-8851805 8.746531e-01 0.058 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.746531e-01 0.058 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 8.746531e-01 0.058 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 8.746531e-01 0.058 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 8.746531e-01 0.058 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.746531e-01 0.058 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.776777e-01 0.057 0 0
Fructose metabolism R-HSA-5652084 8.776777e-01 0.057 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 8.776777e-01 0.057 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 8.776777e-01 0.057 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 8.776777e-01 0.057 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.782768e-01 0.056 0 0
HIV Transcription Initiation R-HSA-167161 8.782768e-01 0.056 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.782768e-01 0.056 0 0
Degradation of CRY and PER proteins R-HSA-9932298 8.782768e-01 0.056 0 0
Intra-Golgi traffic R-HSA-6811438 8.782768e-01 0.056 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 8.805612e-01 0.055 0 0
Viral Messenger RNA Synthesis R-HSA-168325 8.818389e-01 0.055 0 0
Hemostasis R-HSA-109582 8.859174e-01 0.053 1 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.877419e-01 0.052 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.895701e-01 0.051 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.895701e-01 0.051 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 8.895701e-01 0.051 0 0
Biosynthesis of maresins R-HSA-9018682 8.895701e-01 0.051 0 0
Carnitine shuttle R-HSA-200425 8.895701e-01 0.051 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 8.895701e-01 0.051 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 8.895701e-01 0.051 0 0
Growth hormone receptor signaling R-HSA-982772 8.895701e-01 0.051 0 0
Mitochondrial protein import R-HSA-1268020 8.896557e-01 0.051 0 0
FGFR2c ligand binding and activation R-HSA-190375 8.899181e-01 0.051 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.899181e-01 0.051 0 0
FGFR4 ligand binding and activation R-HSA-190322 8.899181e-01 0.051 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 8.899181e-01 0.051 0 0
Chylomicron remodeling R-HSA-8963901 8.899181e-01 0.051 0 0
Mtb iron assimilation by chelation R-HSA-1222449 8.899181e-01 0.051 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 8.899181e-01 0.051 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.899181e-01 0.051 0 0
FGFR3 mutant receptor activation R-HSA-2033514 8.899181e-01 0.051 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.899181e-01 0.051 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.899181e-01 0.051 0 0
Vpu mediated degradation of CD4 R-HSA-180534 8.906948e-01 0.050 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.906948e-01 0.050 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 8.930876e-01 0.049 0 0
Downstream TCR signaling R-HSA-202424 8.935671e-01 0.049 0 0
Influenza Infection R-HSA-168255 8.940800e-01 0.049 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 8.957426e-01 0.048 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.962638e-01 0.048 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 8.962638e-01 0.048 0 0
Signaling by FGFR R-HSA-190236 8.978620e-01 0.047 0 0
Dual Incision in GG-NER R-HSA-5696400 9.000508e-01 0.046 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.000508e-01 0.046 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.000508e-01 0.046 0 0
Signaling by NOTCH2 R-HSA-1980145 9.000508e-01 0.046 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.000508e-01 0.046 0 0
RA biosynthesis pathway R-HSA-5365859 9.000508e-01 0.046 0 0
Ribosome-associated quality control R-HSA-9948299 9.003471e-01 0.046 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.003810e-01 0.046 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 9.003810e-01 0.046 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.011940e-01 0.045 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.022771e-01 0.045 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.032450e-01 0.044 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 9.033249e-01 0.044 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 9.033249e-01 0.044 0 0
FGFR3c ligand binding and activation R-HSA-190372 9.033249e-01 0.044 0 0
The activation of arylsulfatases R-HSA-1663150 9.033249e-01 0.044 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 9.033249e-01 0.044 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 9.033249e-01 0.044 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 9.033249e-01 0.044 0 0
Malate-aspartate shuttle R-HSA-9856872 9.033249e-01 0.044 0 0
Glycerophospholipid catabolism R-HSA-6814848 9.033249e-01 0.044 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.033249e-01 0.044 0 0
Ciprofloxacin ADME R-HSA-9793528 9.033249e-01 0.044 0 0
Signal regulatory protein family interactions R-HSA-391160 9.033249e-01 0.044 0 0
Zinc transporters R-HSA-435354 9.033249e-01 0.044 0 0
P2Y receptors R-HSA-417957 9.033249e-01 0.044 0 0
DAP12 interactions R-HSA-2172127 9.043479e-01 0.044 0 0
IRE1alpha activates chaperones R-HSA-381070 9.055405e-01 0.043 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.086781e-01 0.042 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.086781e-01 0.042 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.086781e-01 0.042 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.101975e-01 0.041 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.101975e-01 0.041 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.101975e-01 0.041 0 0
G protein gated Potassium channels R-HSA-1296059 9.101975e-01 0.041 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.101975e-01 0.041 0 0
Cellular response to hypoxia R-HSA-1234174 9.105145e-01 0.041 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.118678e-01 0.040 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.118690e-01 0.040 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.118690e-01 0.040 0 0
Somitogenesis R-HSA-9824272 9.118690e-01 0.040 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.150995e-01 0.039 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 9.150995e-01 0.039 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.150995e-01 0.039 0 0
Translesion synthesis by REV1 R-HSA-110312 9.150995e-01 0.039 0 0
Signaling by Activin R-HSA-1502540 9.150995e-01 0.039 0 0
FGFR3 ligand binding and activation R-HSA-190239 9.150995e-01 0.039 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 9.150995e-01 0.039 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 9.150995e-01 0.039 0 0
DNA Damage Reversal R-HSA-73942 9.150995e-01 0.039 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.166242e-01 0.038 0 0
GPVI-mediated activation cascade R-HSA-114604 9.166242e-01 0.038 0 0
Glycosphingolipid transport R-HSA-9845576 9.166242e-01 0.038 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.188585e-01 0.037 0 0
Signaling by EGFR in Cancer R-HSA-1643713 9.191014e-01 0.037 0 0
Myogenesis R-HSA-525793 9.191014e-01 0.037 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.191014e-01 0.037 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 9.191014e-01 0.037 0 0
Abacavir ADME R-HSA-2161522 9.191014e-01 0.037 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 9.191014e-01 0.037 0 0
Leishmania infection R-HSA-9658195 9.204884e-01 0.036 0 0
Parasitic Infection Pathways R-HSA-9824443 9.204884e-01 0.036 0 0
Translation of Structural Proteins R-HSA-9694635 9.230203e-01 0.035 0 0
Degradation of AXIN R-HSA-4641257 9.239348e-01 0.034 0 0
XBP1(S) activates chaperone genes R-HSA-381038 9.243262e-01 0.034 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.253472e-01 0.034 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.253472e-01 0.034 0 0
Translesion synthesis by POLI R-HSA-5656121 9.254407e-01 0.034 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.254407e-01 0.034 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.254407e-01 0.034 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 9.254407e-01 0.034 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 9.254407e-01 0.034 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 9.254407e-01 0.034 0 0
Atorvastatin ADME R-HSA-9754706 9.254407e-01 0.034 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.271692e-01 0.033 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.271692e-01 0.033 0 0
Insulin processing R-HSA-264876 9.271692e-01 0.033 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 9.271692e-01 0.033 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.289313e-01 0.032 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.304327e-01 0.031 0 0
Elastic fibre formation R-HSA-1566948 9.306534e-01 0.031 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.306534e-01 0.031 0 0
Gluconeogenesis R-HSA-70263 9.313648e-01 0.031 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 9.340921e-01 0.030 0 0
Regulation of beta-cell development R-HSA-186712 9.340921e-01 0.030 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.345228e-01 0.029 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 9.345228e-01 0.029 0 0
Translesion synthesis by POLK R-HSA-5655862 9.345228e-01 0.029 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.345228e-01 0.029 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.345228e-01 0.029 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.345228e-01 0.029 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.345228e-01 0.029 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.345228e-01 0.029 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 9.345228e-01 0.029 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.345228e-01 0.029 0 0
Coenzyme A biosynthesis R-HSA-196783 9.345228e-01 0.029 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.345228e-01 0.029 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.345228e-01 0.029 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.345228e-01 0.029 0 0
DNA Damage Bypass R-HSA-73893 9.369401e-01 0.028 0 0
Signaling by MET R-HSA-6806834 9.374428e-01 0.028 0 0
GABA receptor activation R-HSA-977443 9.390849e-01 0.027 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.390849e-01 0.027 0 0
Glucagon-type ligand receptors R-HSA-420092 9.410779e-01 0.026 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.410779e-01 0.026 0 0
Diseases of Immune System R-HSA-5260271 9.424796e-01 0.026 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.424796e-01 0.026 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.424990e-01 0.026 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.424990e-01 0.026 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.424990e-01 0.026 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.424990e-01 0.026 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.424990e-01 0.026 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.424990e-01 0.026 0 0
Glycogen storage diseases R-HSA-3229121 9.424990e-01 0.026 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.424990e-01 0.026 0 0
Catecholamine biosynthesis R-HSA-209905 9.424990e-01 0.026 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.424990e-01 0.026 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.424990e-01 0.026 0 0
Choline catabolism R-HSA-6798163 9.424990e-01 0.026 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 9.424990e-01 0.026 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.437348e-01 0.025 0 0
SARS-CoV-2-host interactions R-HSA-9705683 9.438244e-01 0.025 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 9.463532e-01 0.024 0 0
The phototransduction cascade R-HSA-2514856 9.468730e-01 0.024 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.468730e-01 0.024 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.470469e-01 0.024 1 1
Neurotransmitter clearance R-HSA-112311 9.470469e-01 0.024 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.470595e-01 0.024 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.476640e-01 0.023 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.480618e-01 0.023 0 0
tRNA processing in the nucleus R-HSA-6784531 9.480618e-01 0.023 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.494257e-01 0.023 0 0
Activated point mutants of FGFR2 R-HSA-2033519 9.495041e-01 0.023 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.495041e-01 0.023 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.495041e-01 0.023 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.495041e-01 0.023 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.495041e-01 0.023 0 0
Nephron development R-HSA-9831926 9.495041e-01 0.023 0 0
ABC-family proteins mediated transport R-HSA-382556 9.496783e-01 0.022 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.512823e-01 0.022 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.520848e-01 0.021 0 0
Translation of Structural Proteins R-HSA-9683701 9.524105e-01 0.021 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.524365e-01 0.021 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.553529e-01 0.020 0 0
Translesion Synthesis by POLH R-HSA-110320 9.556561e-01 0.020 0 0
Pyrimidine biosynthesis R-HSA-500753 9.556561e-01 0.020 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.556561e-01 0.020 0 0
Regulation of signaling by CBL R-HSA-912631 9.556561e-01 0.020 0 0
Diseases of hemostasis R-HSA-9671793 9.556561e-01 0.020 0 0
GPCR downstream signalling R-HSA-388396 9.563849e-01 0.019 0 0
SARS-CoV Infections R-HSA-9679506 9.565915e-01 0.019 0 0
Mitochondrial protein degradation R-HSA-9837999 9.587984e-01 0.018 0 0
Developmental Cell Lineages R-HSA-9734767 9.608217e-01 0.017 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.610589e-01 0.017 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.610589e-01 0.017 0 0
Glycogen synthesis R-HSA-3322077 9.610589e-01 0.017 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.610589e-01 0.017 0 0
Pregnenolone biosynthesis R-HSA-196108 9.610589e-01 0.017 0 0
G alpha (q) signalling events R-HSA-416476 9.625317e-01 0.017 0 0
Signaling by NOTCH3 R-HSA-9012852 9.625680e-01 0.017 0 0
Surfactant metabolism R-HSA-5683826 9.643449e-01 0.016 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.643871e-01 0.016 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.656336e-01 0.015 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.656336e-01 0.015 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.657549e-01 0.015 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.658037e-01 0.015 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.658037e-01 0.015 0 0
Early Phase of HIV Life Cycle R-HSA-162594 9.658037e-01 0.015 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.658037e-01 0.015 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.658037e-01 0.015 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.658037e-01 0.015 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.658037e-01 0.015 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.658037e-01 0.015 0 0
ABC transporter disorders R-HSA-5619084 9.661811e-01 0.015 0 0
Neddylation R-HSA-8951664 9.665912e-01 0.015 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.687429e-01 0.014 0 0
Interferon Signaling R-HSA-913531 9.688161e-01 0.014 0 0
Signal amplification R-HSA-392518 9.691903e-01 0.014 0 0
ER-Phagosome pathway R-HSA-1236974 9.697778e-01 0.013 0 0
Attachment and Entry R-HSA-9694614 9.699706e-01 0.013 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.699706e-01 0.013 0 0
Glutathione synthesis and recycling R-HSA-174403 9.699706e-01 0.013 0 0
Assembly Of The HIV Virion R-HSA-175474 9.699706e-01 0.013 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.713845e-01 0.013 0 0
Neurotransmitter release cycle R-HSA-112310 9.719774e-01 0.012 0 0
Immune System R-HSA-168256 9.722010e-01 0.012 0 0
PERK regulates gene expression R-HSA-381042 9.723908e-01 0.012 0 0
Oncogene Induced Senescence R-HSA-2559585 9.723908e-01 0.012 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.723908e-01 0.012 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.723908e-01 0.012 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.726454e-01 0.012 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 9.730223e-01 0.012 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.733396e-01 0.012 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.736300e-01 0.012 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 9.736300e-01 0.012 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 9.736300e-01 0.012 0 0
Toll-like Receptor Cascades R-HSA-168898 9.759436e-01 0.011 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.761384e-01 0.010 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.768436e-01 0.010 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.768436e-01 0.010 0 0
Formation of the ureteric bud R-HSA-9830674 9.768436e-01 0.010 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.768436e-01 0.010 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.768436e-01 0.010 0 0
Signaling by Insulin receptor R-HSA-74752 9.777249e-01 0.010 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.777249e-01 0.010 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.778560e-01 0.010 0 0
Metabolism of folate and pterines R-HSA-196757 9.778560e-01 0.010 0 0
Collagen chain trimerization R-HSA-8948216 9.778560e-01 0.010 0 0
CYP2E1 reactions R-HSA-211999 9.796658e-01 0.009 0 0
Complex III assembly R-HSA-9865881 9.796658e-01 0.009 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.796658e-01 0.009 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.796658e-01 0.009 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.796658e-01 0.009 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.796658e-01 0.009 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.796658e-01 0.009 0 0
rRNA processing R-HSA-72312 9.808999e-01 0.008 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.821442e-01 0.008 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.821442e-01 0.008 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.821442e-01 0.008 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.821507e-01 0.008 0 0
Pentose phosphate pathway R-HSA-71336 9.822665e-01 0.008 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 9.822665e-01 0.008 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.822665e-01 0.008 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.836461e-01 0.007 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.841390e-01 0.007 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.841390e-01 0.007 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 9.843206e-01 0.007 0 0
MET activates PTK2 signaling R-HSA-8874081 9.843206e-01 0.007 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.843206e-01 0.007 0 0
Urea cycle R-HSA-70635 9.843206e-01 0.007 0 0
Sphingolipid catabolism R-HSA-9845614 9.843206e-01 0.007 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.849114e-01 0.007 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.856532e-01 0.006 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.859022e-01 0.006 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.862318e-01 0.006 0 0
Triglyceride biosynthesis R-HSA-75109 9.862318e-01 0.006 0 0
Synthesis of PE R-HSA-1483213 9.862318e-01 0.006 0 0
Signaling by BMP R-HSA-201451 9.862318e-01 0.006 0 0
Cholesterol biosynthesis R-HSA-191273 9.865892e-01 0.006 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.871678e-01 0.006 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.875547e-01 0.005 0 0
Prednisone ADME R-HSA-9757110 9.879102e-01 0.005 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.879102e-01 0.005 0 0
Platelet degranulation R-HSA-114608 9.880572e-01 0.005 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.886743e-01 0.005 0 0
Activation of GABAB receptors R-HSA-991365 9.886743e-01 0.005 0 0
GABA B receptor activation R-HSA-977444 9.886743e-01 0.005 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.886743e-01 0.005 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.886799e-01 0.005 0 0
Thyroxine biosynthesis R-HSA-209968 9.893841e-01 0.005 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.893841e-01 0.005 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.898834e-01 0.004 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.906457e-01 0.004 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 9.906783e-01 0.004 0 0
Mucopolysaccharidoses R-HSA-2206281 9.906783e-01 0.004 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.907448e-01 0.004 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.909363e-01 0.004 0 0
Leishmania phagocytosis R-HSA-9664417 9.913811e-01 0.004 0 0
Parasite infection R-HSA-9664407 9.913811e-01 0.004 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.913811e-01 0.004 0 0
Cargo concentration in the ER R-HSA-5694530 9.918149e-01 0.004 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.918149e-01 0.004 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.921155e-01 0.003 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.921155e-01 0.003 0 0
Collagen formation R-HSA-1474290 9.923705e-01 0.003 0 0
DAG1 glycosylations R-HSA-8931838 9.928129e-01 0.003 0 0
HS-GAG degradation R-HSA-2024096 9.928129e-01 0.003 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.928165e-01 0.003 0 0
Metabolism of polyamines R-HSA-351202 9.928931e-01 0.003 0 0
Selenoamino acid metabolism R-HSA-2408522 9.935874e-01 0.003 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.936893e-01 0.003 0 0
Signaling by GPCR R-HSA-372790 9.942591e-01 0.003 0 0
CS/DS degradation R-HSA-2024101 9.944588e-01 0.002 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.944588e-01 0.002 0 0
Heme degradation R-HSA-189483 9.944588e-01 0.002 0 0
Phospholipid metabolism R-HSA-1483257 9.950441e-01 0.002 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.950936e-01 0.002 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.951346e-01 0.002 0 0
eNOS activation R-HSA-203615 9.951346e-01 0.002 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.951346e-01 0.002 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.951346e-01 0.002 0 0
Hyaluronan metabolism R-HSA-2142845 9.951346e-01 0.002 0 0
Interleukin-10 signaling R-HSA-6783783 9.957040e-01 0.002 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.957280e-01 0.002 0 0
Complex IV assembly R-HSA-9864848 9.959406e-01 0.002 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.962149e-01 0.002 0 0
HS-GAG biosynthesis R-HSA-2022928 9.962490e-01 0.002 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.962490e-01 0.002 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.963098e-01 0.002 0 0
Metabolism of steroid hormones R-HSA-196071 9.965959e-01 0.001 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.967065e-01 0.001 0 0
NCAM1 interactions R-HSA-419037 9.967065e-01 0.001 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.967065e-01 0.001 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.967065e-01 0.001 0 0
Lysine catabolism R-HSA-71064 9.967065e-01 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 9.967771e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.968303e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.968303e-01 0.001 0 0
Viral Infection Pathways R-HSA-9824446 9.970669e-01 0.001 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.971083e-01 0.001 0 0
Purine salvage R-HSA-74217 9.971083e-01 0.001 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.973590e-01 0.001 0 0
RSV-host interactions R-HSA-9833110 9.973671e-01 0.001 0 0
Paracetamol ADME R-HSA-9753281 9.974435e-01 0.001 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.974610e-01 0.001 0 0
RAS processing R-HSA-9648002 9.974610e-01 0.001 1 1
SLC transporter disorders R-HSA-5619102 9.975814e-01 0.001 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.977708e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.977794e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.977794e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.977794e-01 0.001 1 0
Retinoid metabolism and transport R-HSA-975634 9.977794e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.979738e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.979738e-01 0.001 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.980058e-01 0.001 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.980427e-01 0.001 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.982095e-01 0.001 0 0
Heme biosynthesis R-HSA-189451 9.982816e-01 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.983928e-01 0.001 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.984134e-01 0.001 0 0
Pyruvate metabolism R-HSA-70268 9.984236e-01 0.001 0 0
Iron uptake and transport R-HSA-917937 9.985577e-01 0.001 0 0
RAB geranylgeranylation R-HSA-8873719 9.985724e-01 0.001 0 0
tRNA Aminoacylation R-HSA-379724 9.985724e-01 0.001 0 0
Defensins R-HSA-1461973 9.986753e-01 0.001 0 0
Protein localization R-HSA-9609507 9.987138e-01 0.001 0 0
Collagen degradation R-HSA-1442490 9.987302e-01 0.001 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.988370e-01 0.001 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.988370e-01 0.001 0 0
Integrin cell surface interactions R-HSA-216083 9.989592e-01 0.000 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.989789e-01 0.000 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.989789e-01 0.000 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.991035e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.991725e-01 0.000 0 0
Synthesis of PC R-HSA-1483191 9.992129e-01 0.000 0 0
Interferon gamma signaling R-HSA-877300 9.992136e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.992505e-01 0.000 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.993090e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.993281e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.993427e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.993464e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.993733e-01 0.000 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.993934e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.994432e-01 0.000 0 0
COPII-mediated vesicle transport R-HSA-204005 9.995607e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.996658e-01 0.000 0 0
G alpha (z) signalling events R-HSA-418597 9.997223e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.997223e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.997328e-01 0.000 0 0
Digestion R-HSA-8935690 9.997562e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.997613e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.997818e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.998039e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.998350e-01 0.000 0 0
Peroxisomal protein import R-HSA-9033241 9.998350e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.998552e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.998729e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.998743e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.998818e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.998993e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.999020e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999020e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999133e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.999140e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.999140e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999197e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999245e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999261e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999309e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999418e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999433e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.999516e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999539e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999546e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999549e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999607e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999646e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.999655e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999661e-01 0.000 0 0
tRNA processing R-HSA-72306 9.999698e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999734e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999795e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999796e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999838e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999861e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999866e-01 0.000 0 0
Translation R-HSA-72766 9.999870e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999878e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999907e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999937e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999957e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999968e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999970e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999979e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999979e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999985e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999996e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999997e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999999e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999999e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999999e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999999e-01 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 1.000000e+00 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 1 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 1 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 7.881584e-12 11.103 0 0
Cell Cycle Checkpoints R-HSA-69620 3.588940e-11 10.445 0 0
HSF1-dependent transactivation R-HSA-3371571 4.967893e-11 10.304 0 0
Attenuation phase R-HSA-3371568 5.215939e-11 10.283 0 0
Cellular Senescence R-HSA-2559583 6.376529e-10 9.195 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 8.132044e-10 9.090 0 0
HSF1 activation R-HSA-3371511 1.467161e-09 8.834 0 0
Chromatin modifying enzymes R-HSA-3247509 1.646277e-09 8.783 0 0
DNA Double Strand Break Response R-HSA-5693606 2.278927e-09 8.642 0 0
Chromatin organization R-HSA-4839726 2.283059e-09 8.641 0 0
Cell Cycle R-HSA-1640170 4.922001e-09 8.308 0 0
Cellular response to heat stress R-HSA-3371556 1.398396e-08 7.854 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.438414e-08 7.842 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 3.443782e-08 7.463 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 3.282195e-08 7.484 0 0
Cellular responses to stimuli R-HSA-8953897 1.270915e-07 6.896 0 0
Cellular responses to stress R-HSA-2262752 1.526788e-07 6.816 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.748367e-07 6.757 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.921749e-07 6.716 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.687763e-07 6.571 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.841248e-07 6.233 0 0
Cell-Cell communication R-HSA-1500931 5.635393e-07 6.249 0 0
Signal Transduction R-HSA-162582 6.685176e-07 6.175 1 0
Estrogen-dependent gene expression R-HSA-9018519 8.489185e-07 6.071 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 8.628818e-07 6.064 0 0
Processing of DNA double-strand break ends R-HSA-5693607 9.014424e-07 6.045 0 0
G2/M Checkpoints R-HSA-69481 1.030362e-06 5.987 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.175100e-06 5.930 0 0
Apoptotic execution phase R-HSA-75153 1.256471e-06 5.901 0 0
Signaling by ROBO receptors R-HSA-376176 1.605139e-06 5.794 0 0
Cell Cycle, Mitotic R-HSA-69278 1.802528e-06 5.744 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.329866e-06 5.633 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.329866e-06 5.633 0 0
M Phase R-HSA-68886 2.584876e-06 5.588 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.658421e-06 5.575 0 0
Chaperone Mediated Autophagy R-HSA-9613829 6.140065e-06 5.212 0 0
Cell junction organization R-HSA-446728 6.979118e-06 5.156 0 0
Defective pyroptosis R-HSA-9710421 7.952326e-06 5.100 0 0
Nervous system development R-HSA-9675108 8.957631e-06 5.048 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.068041e-05 4.971 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.080420e-05 4.966 0 0
HDACs deacetylate histones R-HSA-3214815 1.176323e-05 4.929 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.309022e-05 4.883 0 0
Nucleosome assembly R-HSA-774815 1.318170e-05 4.880 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.318170e-05 4.880 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.343244e-05 4.872 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.680754e-05 4.774 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 1.789476e-05 4.747 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.209787e-05 4.656 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.240662e-05 4.650 0 0
Signaling by ALK in cancer R-HSA-9700206 2.240662e-05 4.650 0 0
Meiotic synapsis R-HSA-1221632 2.477706e-05 4.606 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.936732e-05 4.532 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.331558e-05 4.477 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 3.629218e-05 4.440 0 0
Intracellular signaling by second messengers R-HSA-9006925 3.895977e-05 4.409 0 0
Axon guidance R-HSA-422475 4.625986e-05 4.335 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 4.962282e-05 4.304 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 5.689996e-05 4.245 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 5.689996e-05 4.245 0 0
Signaling downstream of RAS mutants R-HSA-9649948 5.689996e-05 4.245 0 0
Signaling by RAS mutants R-HSA-6802949 5.689996e-05 4.245 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 6.396462e-05 4.194 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 6.396566e-05 4.194 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 6.932185e-05 4.159 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 7.129699e-05 4.147 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 7.846557e-05 4.105 0 0
DNA methylation R-HSA-5334118 8.392052e-05 4.076 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 8.770727e-05 4.057 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.114862e-04 3.953 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.217327e-04 3.915 0 0
Homology Directed Repair R-HSA-5693538 1.320118e-04 3.879 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.420301e-04 3.848 0 0
Adherens junctions interactions R-HSA-418990 1.543110e-04 3.812 0 0
Protein ubiquitination R-HSA-8852135 1.737984e-04 3.760 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.819602e-04 3.740 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.768556e-04 3.752 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.770187e-04 3.752 0 0
Packaging Of Telomere Ends R-HSA-171306 1.876389e-04 3.727 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.876389e-04 3.727 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.033574e-04 3.692 0 0
Diseases of programmed cell death R-HSA-9645723 2.201945e-04 3.657 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.376677e-04 3.624 0 0
HATs acetylate histones R-HSA-3214847 2.260205e-04 3.646 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.334937e-04 3.632 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.334937e-04 3.632 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.376677e-04 3.624 0 0
Regulation of TP53 Activity R-HSA-5633007 2.332001e-04 3.632 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.661361e-04 3.575 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.891121e-04 3.539 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.226643e-04 3.491 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.452861e-04 3.462 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.452861e-04 3.462 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.502216e-04 3.456 0 0
Mitotic Prophase R-HSA-68875 3.738202e-04 3.427 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.762250e-04 3.425 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 3.793687e-04 3.421 0 0
Cell-cell junction organization R-HSA-421270 3.797984e-04 3.420 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 4.257562e-04 3.371 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 4.045985e-04 3.393 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 4.589677e-04 3.338 0 0
Epigenetic regulation of gene expression R-HSA-212165 4.761763e-04 3.322 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 4.945602e-04 3.306 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 4.996983e-04 3.301 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 5.417788e-04 3.266 0 0
TCF dependent signaling in response to WNT R-HSA-201681 5.820107e-04 3.235 0 0
Regulation of PTEN localization R-HSA-8948747 6.306309e-04 3.200 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 6.479657e-04 3.188 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 6.510092e-04 3.186 0 0
Formation of a pool of free 40S subunits R-HSA-72689 7.287382e-04 3.137 0 0
Mitotic Prometaphase R-HSA-68877 7.315289e-04 3.136 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 7.229125e-04 3.141 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 7.229125e-04 3.141 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 6.910647e-04 3.160 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 7.229125e-04 3.141 0 0
ESR-mediated signaling R-HSA-8939211 7.374311e-04 3.132 0 0
Meiosis R-HSA-1500620 7.441609e-04 3.128 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 7.994875e-04 3.097 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 8.274926e-04 3.082 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 8.274926e-04 3.082 0 0
Amplification of signal from the kinetochores R-HSA-141424 8.486103e-04 3.071 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 8.486103e-04 3.071 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 8.936052e-04 3.049 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 8.519509e-04 3.070 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 8.551481e-04 3.068 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 9.304753e-04 3.031 0 0
PIP3 activates AKT signaling R-HSA-1257604 9.890319e-04 3.005 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.026408e-03 2.989 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.096768e-03 2.960 0 0
Apoptosis R-HSA-109581 1.099063e-03 2.959 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.141288e-03 2.943 0 0
Metabolism of RNA R-HSA-8953854 1.152392e-03 2.938 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.176092e-03 2.930 0 0
Negative regulation of FLT3 R-HSA-9706369 1.176681e-03 2.929 0 0
Peptide chain elongation R-HSA-156902 1.241151e-03 2.906 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.268932e-03 2.897 0 0
Meiotic recombination R-HSA-912446 1.315884e-03 2.881 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.317771e-03 2.880 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.424488e-03 2.846 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.485484e-03 2.828 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.445791e-03 2.840 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.456017e-03 2.837 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.550982e-03 2.809 0 0
Signaling by VEGF R-HSA-194138 1.484609e-03 2.828 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 1.589713e-03 2.799 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.557878e-03 2.807 0 0
Mitotic Anaphase R-HSA-68882 1.490684e-03 2.827 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.557878e-03 2.807 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.605279e-03 2.794 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.640500e-03 2.785 0 0
RNA Polymerase I Transcription R-HSA-73864 1.648635e-03 2.783 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.709041e-03 2.767 0 0
FLT3 signaling in disease R-HSA-9682385 1.817988e-03 2.740 0 0
MAP2K and MAPK activation R-HSA-5674135 1.860261e-03 2.730 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.860261e-03 2.730 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.120442e-03 2.674 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.060500e-03 2.686 0 0
Cleavage of the damaged purine R-HSA-110331 2.189123e-03 2.660 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 2.209503e-03 2.656 0 0
Depyrimidination R-HSA-73928 2.209503e-03 2.656 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 2.361778e-03 2.627 0 0
Josephin domain DUBs R-HSA-5689877 2.361778e-03 2.627 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.465321e-03 2.608 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.480681e-03 2.605 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.510962e-03 2.600 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.510962e-03 2.600 0 0
G2/M Transition R-HSA-69275 2.523015e-03 2.598 0 0
Depurination R-HSA-73927 2.619947e-03 2.582 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.735862e-03 2.563 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.771288e-03 2.557 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.933181e-03 2.533 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 3.042823e-03 2.517 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 3.080519e-03 2.511 0 0
Striated Muscle Contraction R-HSA-390522 3.080519e-03 2.511 0 0
mRNA Splicing R-HSA-72172 3.307196e-03 2.481 0 0
p75NTR signals via NF-kB R-HSA-193639 3.666472e-03 2.436 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.466234e-03 2.460 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 3.386698e-03 2.470 0 0
Glycogen metabolism R-HSA-8982491 3.688375e-03 2.433 0 0
RAF activation R-HSA-5673000 3.696671e-03 2.432 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 3.848227e-03 2.415 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.952247e-03 2.403 0 0
mRNA 3'-end processing R-HSA-72187 3.974931e-03 2.401 0 0
Co-inhibition by PD-1 R-HSA-389948 4.005213e-03 2.397 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 4.220145e-03 2.375 0 0
AURKA Activation by TPX2 R-HSA-8854518 4.484287e-03 2.348 0 0
Nephrin family interactions R-HSA-373753 4.539059e-03 2.343 0 0
Negative regulation of MET activity R-HSA-6807004 4.539059e-03 2.343 0 0
Smooth Muscle Contraction R-HSA-445355 4.575676e-03 2.340 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 4.630712e-03 2.334 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.630712e-03 2.334 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 4.650789e-03 2.332 0 0
Activation of HOX genes during differentiation R-HSA-5619507 4.650789e-03 2.332 0 0
NF-kB is activated and signals survival R-HSA-209560 4.710508e-03 2.327 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 4.756244e-03 2.323 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 5.027735e-03 2.299 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 5.027735e-03 2.299 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 5.707060e-03 2.244 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 5.707060e-03 2.244 0 0
Centrosome maturation R-HSA-380287 5.836728e-03 2.234 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 5.836728e-03 2.234 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 5.207373e-03 2.283 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 5.339361e-03 2.273 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 5.707060e-03 2.244 0 0
Amyloid fiber formation R-HSA-977225 5.274787e-03 2.278 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 6.174974e-03 2.209 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 6.380231e-03 2.195 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 6.380231e-03 2.195 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 6.380231e-03 2.195 0 0
p75NTR recruits signalling complexes R-HSA-209543 6.380231e-03 2.195 0 0
Death Receptor Signaling R-HSA-73887 6.560854e-03 2.183 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 6.830081e-03 2.166 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 6.926219e-03 2.160 0 0
Developmental Biology R-HSA-1266738 6.927661e-03 2.159 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 7.066200e-03 2.151 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 7.066200e-03 2.151 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 7.082007e-03 2.150 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 7.082007e-03 2.150 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 7.329237e-03 2.135 0 0
DNA Replication Pre-Initiation R-HSA-69002 7.403025e-03 2.131 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 7.403025e-03 2.131 0 0
FGFR1 mutant receptor activation R-HSA-1839124 7.416898e-03 2.130 0 0
Signaling by Nuclear Receptors R-HSA-9006931 7.505135e-03 2.125 0 0
Regulation of CDH1 Function R-HSA-9764561 7.752614e-03 2.111 0 0
Separation of Sister Chromatids R-HSA-2467813 7.768825e-03 2.110 0 0
Signaling by WNT R-HSA-195721 7.901388e-03 2.102 1 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 9.929420e-03 2.003 0 0
Aggrephagy R-HSA-9646399 9.738728e-03 2.011 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.596526e-03 2.018 0 0
Ub-specific processing proteases R-HSA-5689880 9.066417e-03 2.043 0 0
DAG and IP3 signaling R-HSA-1489509 9.112555e-03 2.040 0 0
Polo-like kinase mediated events R-HSA-156711 9.929420e-03 2.003 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 8.571010e-03 2.067 0 0
Muscle contraction R-HSA-397014 9.359301e-03 2.029 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 8.670588e-03 2.062 0 0
Reproduction R-HSA-1474165 9.208744e-03 2.036 0 0
Maturation of protein E R-HSA-9683683 9.458316e-03 2.024 0 0
Maturation of protein E R-HSA-9694493 9.458316e-03 2.024 0 0
Programmed Cell Death R-HSA-5357801 9.934689e-03 2.003 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.006177e-02 1.997 0 0
Ribosome-associated quality control R-HSA-9948299 1.023330e-02 1.990 0 0
Late endosomal microautophagy R-HSA-9615710 1.056828e-02 1.976 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.060198e-02 1.975 0 0
Deubiquitination R-HSA-5688426 1.090938e-02 1.962 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.094466e-02 1.961 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.094466e-02 1.961 0 0
PTEN Regulation R-HSA-6807070 1.102059e-02 1.958 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.112380e-02 1.954 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.112380e-02 1.954 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.112380e-02 1.954 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.112380e-02 1.954 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.112380e-02 1.954 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.117812e-02 1.952 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.117812e-02 1.952 0 0
Pexophagy R-HSA-9664873 1.117812e-02 1.952 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.117812e-02 1.952 0 0
FLT3 Signaling R-HSA-9607240 1.123586e-02 1.949 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 1.400835e-02 1.854 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.392984e-02 1.856 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.392984e-02 1.856 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.228725e-02 1.911 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.290275e-02 1.889 0 0
Translation initiation complex formation R-HSA-72649 1.228468e-02 1.911 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.247117e-02 1.904 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.388000e-02 1.858 0 0
EGFR downregulation R-HSA-182971 1.464476e-02 1.834 0 0
PLC beta mediated events R-HSA-112043 1.247117e-02 1.904 0 0
CaM pathway R-HSA-111997 1.385269e-02 1.858 0 0
Calmodulin induced events R-HSA-111933 1.385269e-02 1.858 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.392984e-02 1.856 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.350395e-02 1.870 0 0
Eukaryotic Translation Termination R-HSA-72764 1.388000e-02 1.858 0 0
Signaling by NOTCH1 R-HSA-1980143 1.371112e-02 1.863 0 0
RNA Polymerase II Transcription R-HSA-73857 1.418086e-02 1.848 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.228468e-02 1.911 0 0
Interleukin-12 signaling R-HSA-9020591 1.371112e-02 1.863 0 0
Ca-dependent events R-HSA-111996 1.475076e-02 1.831 0 0
MTOR signalling R-HSA-165159 1.475076e-02 1.831 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.492979e-02 1.826 0 0
HDMs demethylate histones R-HSA-3214842 1.512130e-02 1.820 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.527841e-02 1.816 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.527841e-02 1.816 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.527841e-02 1.816 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.581477e-02 1.801 0 0
Membrane Trafficking R-HSA-199991 1.632066e-02 1.787 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.744020e-02 1.758 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 1.789222e-02 1.747 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.793805e-02 1.746 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.793805e-02 1.746 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.793805e-02 1.746 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.793805e-02 1.746 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.793805e-02 1.746 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.816819e-02 1.741 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.816819e-02 1.741 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.816819e-02 1.741 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 1.816819e-02 1.741 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.934089e-02 1.714 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.936662e-02 1.713 0 0
Activation of RAC1 R-HSA-428540 1.944198e-02 1.711 0 0
Signaling by AXIN mutants R-HSA-4839735 1.944198e-02 1.711 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 1.974767e-02 1.704 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.974767e-02 1.704 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 2.100934e-02 1.678 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.100934e-02 1.678 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 2.174813e-02 1.663 0 0
Chromosome Maintenance R-HSA-73886 2.261850e-02 1.646 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 2.278030e-02 1.642 0 0
Selenocysteine synthesis R-HSA-2408557 2.283282e-02 1.641 0 0
G-protein mediated events R-HSA-112040 2.338737e-02 1.631 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.376460e-02 1.624 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 2.385798e-02 1.622 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 2.385798e-02 1.622 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 2.385798e-02 1.622 0 0
Dopamine receptors R-HSA-390651 2.385798e-02 1.622 0 0
Ephrin signaling R-HSA-3928664 3.148713e-02 1.502 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.836123e-02 1.547 0 0
Viral mRNA Translation R-HSA-192823 2.663392e-02 1.575 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.723320e-02 1.565 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.688593e-02 1.570 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 3.094595e-02 1.509 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.973961e-02 1.527 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 2.674999e-02 1.573 0 0
DNA Repair R-HSA-73894 2.899578e-02 1.538 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 3.094595e-02 1.509 0 0
rRNA processing R-HSA-72312 2.804442e-02 1.552 0 0
Gene expression (Transcription) R-HSA-74160 2.699178e-02 1.569 0 0
Signaling by NOTCH2 R-HSA-1980145 2.609632e-02 1.583 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 2.674999e-02 1.573 0 0
Modulation by Mtb of host immune system R-HSA-9637628 2.674999e-02 1.573 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 3.148713e-02 1.502 0 0
Signaling by EGFR R-HSA-177929 3.300641e-02 1.481 0 0
TNF signaling R-HSA-75893 3.300641e-02 1.481 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.372390e-02 1.472 0 0
Calcineurin activates NFAT R-HSA-2025928 3.506351e-02 1.455 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 3.521077e-02 1.453 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.564406e-02 1.448 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.694128e-02 1.432 0 0
Regulation of signaling by CBL R-HSA-912631 3.744160e-02 1.427 0 0
Rap1 signalling R-HSA-392517 3.744160e-02 1.427 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 3.778269e-02 1.423 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 3.778269e-02 1.423 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.778269e-02 1.423 0 0
Hedgehog 'off' state R-HSA-5610787 3.780461e-02 1.422 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 3.801281e-02 1.420 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 3.801281e-02 1.420 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 3.801281e-02 1.420 0 0
Interleukin-12 family signaling R-HSA-447115 3.931567e-02 1.405 0 0
Generic Transcription Pathway R-HSA-212436 4.056388e-02 1.392 0 0
Signaling by NOTCH R-HSA-157118 4.086985e-02 1.389 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 4.089974e-02 1.388 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.242249e-02 1.372 0 0
Clathrin-mediated endocytosis R-HSA-8856828 4.293444e-02 1.367 0 0
Signaling by FGFR in disease R-HSA-1226099 4.368957e-02 1.360 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 4.407021e-02 1.356 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 4.486316e-02 1.348 0 0
Protein methylation R-HSA-8876725 4.598964e-02 1.337 0 0
Spry regulation of FGF signaling R-HSA-1295596 4.598964e-02 1.337 0 0
Metalloprotease DUBs R-HSA-5689901 4.699202e-02 1.328 0 0
Signaling by EGFR in Cancer R-HSA-1643713 4.699202e-02 1.328 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.699202e-02 1.328 0 0
Nuclear RNA decay R-HSA-9930044 4.800804e-02 1.319 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 4.800804e-02 1.319 0 0
Kinesins R-HSA-983189 4.805871e-02 1.318 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 4.886947e-02 1.311 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 4.886947e-02 1.311 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 4.886947e-02 1.311 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 6.291595e-02 1.201 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 6.291595e-02 1.201 0 0
Regulation of cortical dendrite branching R-HSA-8985801 6.291595e-02 1.201 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 6.291595e-02 1.201 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 6.291595e-02 1.201 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 6.291595e-02 1.201 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 6.291595e-02 1.201 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 6.291595e-02 1.201 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 6.291595e-02 1.201 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 6.291595e-02 1.201 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 6.291595e-02 1.201 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 6.291595e-02 1.201 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 6.291595e-02 1.201 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.472455e-02 1.189 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.472455e-02 1.189 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 5.569651e-02 1.254 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 5.569651e-02 1.254 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 5.569651e-02 1.254 0 0
Phase 4 - resting membrane potential R-HSA-5576886 5.488890e-02 1.261 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.363431e-02 1.271 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.050923e-02 1.218 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 5.190521e-02 1.285 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 6.540906e-02 1.184 0 0
EPH-Ephrin signaling R-HSA-2682334 6.060542e-02 1.217 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.866163e-02 1.232 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 5.915858e-02 1.228 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 6.204459e-02 1.207 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 4.959944e-02 1.305 0 0
Regulation of TNFR1 signaling R-HSA-5357905 5.190521e-02 1.285 0 0
Autophagy R-HSA-9612973 5.566621e-02 1.254 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 5.278775e-02 1.277 0 0
Signaling by APC mutants R-HSA-4839744 5.569651e-02 1.254 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 5.363431e-02 1.271 0 0
NGF-stimulated transcription R-HSA-9031628 6.285632e-02 1.202 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 6.471330e-02 1.189 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 6.546781e-02 1.184 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 5.138803e-02 1.289 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 5.190521e-02 1.285 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 6.471330e-02 1.189 0 0
Assembly Of The HIV Virion R-HSA-175474 5.940480e-02 1.226 0 0
Base Excision Repair R-HSA-73884 4.915465e-02 1.308 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 5.582781e-02 1.253 0 0
Translation of Structural Proteins R-HSA-9683701 6.540906e-02 1.184 0 0
Signaling by PDGFR in disease R-HSA-9671555 5.940480e-02 1.226 0 0
NRAGE signals death through JNK R-HSA-193648 6.546781e-02 1.184 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 6.799757e-02 1.168 0 0
Signaling by GSK3beta mutants R-HSA-5339716 6.799757e-02 1.168 0 0
Integration of provirus R-HSA-162592 6.799757e-02 1.168 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 6.799757e-02 1.168 0 0
Signaling by AMER1 mutants R-HSA-4839748 6.799757e-02 1.168 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 6.799757e-02 1.168 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 6.799757e-02 1.168 0 0
mTORC1-mediated signalling R-HSA-166208 6.812491e-02 1.167 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 6.838329e-02 1.165 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 6.860009e-02 1.164 0 0
Signaling by MET R-HSA-6806834 6.901646e-02 1.161 0 0
Nuclear Envelope Breakdown R-HSA-2980766 7.120176e-02 1.148 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 7.120176e-02 1.148 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 7.206085e-02 1.142 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 7.361827e-02 1.133 0 0
Selective autophagy R-HSA-9663891 7.403722e-02 1.131 0 0
Glycogen storage diseases R-HSA-3229121 7.545617e-02 1.122 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 7.693090e-02 1.114 0 0
Signaling by ERBB4 R-HSA-1236394 7.910603e-02 1.102 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 8.157749e-02 1.088 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 8.157749e-02 1.088 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 8.157749e-02 1.088 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 8.157749e-02 1.088 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 8.157749e-02 1.088 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 8.157749e-02 1.088 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 8.157749e-02 1.088 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.157749e-02 1.088 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.157749e-02 1.088 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.157749e-02 1.088 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 8.160094e-02 1.088 0 0
Opioid Signalling R-HSA-111885 8.254354e-02 1.083 0 0
Response of endothelial cells to shear stress R-HSA-9860931 8.254354e-02 1.083 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 8.254354e-02 1.083 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 8.262390e-02 1.083 0 0
Ovarian tumor domain proteases R-HSA-5689896 8.277221e-02 1.082 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 8.277221e-02 1.082 0 0
Budding and maturation of HIV virion R-HSA-162588 8.582641e-02 1.066 0 0
RMTs methylate histone arginines R-HSA-3214858 8.657728e-02 1.063 0 0
MAPK family signaling cascades R-HSA-5683057 8.673192e-02 1.062 1 0
PKA activation R-HSA-163615 8.710207e-02 1.060 0 0
Platelet sensitization by LDL R-HSA-432142 8.710207e-02 1.060 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 8.766667e-02 1.057 0 0
Telomere Maintenance R-HSA-157579 8.866407e-02 1.052 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 8.894573e-02 1.051 0 0
Signaling by FGFR1 amplification mutants R-HSA-1839120 9.213604e-02 1.036 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.444243e-02 1.025 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.444243e-02 1.025 0 0
MITF-M-dependent gene expression R-HSA-9856651 9.482872e-02 1.023 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.528217e-02 1.021 0 0
Diseases of mitotic cell cycle R-HSA-9675126 9.528217e-02 1.021 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 9.528217e-02 1.021 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.591773e-02 1.018 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 9.608179e-02 1.017 0 0
Deletions in the AXIN1 gene destabilize the destruction complex R-HSA-5467345 9.632782e-02 1.016 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 9.635160e-02 1.016 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 9.638289e-02 1.016 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 9.638289e-02 1.016 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 9.638289e-02 1.016 0 0
Maturation of nucleoprotein R-HSA-9683610 9.638289e-02 1.016 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 9.703015e-02 1.013 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.244234e-01 0.905 0 0
Type I hemidesmosome assembly R-HSA-446107 1.023861e-01 0.990 0 0
Formation of annular gap junctions R-HSA-196025 1.023861e-01 0.990 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.238111e-01 0.907 0 0
Lipophagy R-HSA-9613354 1.238111e-01 0.907 0 0
Gap junction degradation R-HSA-190873 1.238111e-01 0.907 0 0
PI3K/AKT activation R-HSA-198203 1.466889e-01 0.834 0 0
2-LTR circle formation R-HSA-164843 1.466889e-01 0.834 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.466889e-01 0.834 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.293930e-01 0.888 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.421393e-01 0.847 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.421393e-01 0.847 0 0
Cristae formation R-HSA-8949613 1.220722e-01 0.913 0 0
Dual Incision in GG-NER R-HSA-5696400 1.269204e-01 0.896 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.292152e-01 0.889 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 1.292152e-01 0.889 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.398479e-01 0.854 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.206723e-01 0.918 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.397047e-01 0.855 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.189495e-01 0.925 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.271864e-01 0.896 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 1.038623e-01 0.984 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.266181e-01 0.898 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.266181e-01 0.898 0 0
Translesion Synthesis by POLH R-HSA-110320 9.962745e-02 1.002 0 0
Post NMDA receptor activation events R-HSA-438064 1.155612e-01 0.937 0 0
G alpha (12/13) signalling events R-HSA-416482 1.036117e-01 0.985 0 0
Developmental Cell Lineages R-HSA-9734767 1.017467e-01 0.992 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.130014e-01 0.947 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.271864e-01 0.896 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.266181e-01 0.898 0 0
Translesion synthesis by REV1 R-HSA-110312 1.293930e-01 0.888 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 1.238111e-01 0.907 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.189495e-01 0.925 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.043362e-01 0.982 0 0
Sema4D in semaphorin signaling R-HSA-400685 9.847152e-02 1.007 0 0
RAF/MAP kinase cascade R-HSA-5673001 9.969515e-02 1.001 1 0
Stabilization of p53 R-HSA-69541 9.996973e-02 1.000 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.247562e-01 0.904 1 0
Hedgehog 'on' state R-HSA-5632684 1.115033e-01 0.953 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 1.023861e-01 0.990 0 0
Glycogen synthesis R-HSA-3322077 1.130014e-01 0.947 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.052906e-01 0.978 0 0
Macroautophagy R-HSA-1632852 1.309021e-01 0.883 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 1.092657e-01 0.962 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.238111e-01 0.907 0 0
Regulation of KIT signaling R-HSA-1433559 1.123472e-01 0.949 0 0
DCC mediated attractive signaling R-HSA-418885 1.293930e-01 0.888 0 0
NOD1/2 Signaling Pathway R-HSA-168638 1.269204e-01 0.896 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.269204e-01 0.896 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 1.398479e-01 0.854 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.429327e-01 0.845 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.184058e-01 0.927 0 0
Cellular response to starvation R-HSA-9711097 1.341393e-01 0.872 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.052906e-01 0.978 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.052906e-01 0.978 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 1.052906e-01 0.978 0 0
Basigin interactions R-HSA-210991 1.271864e-01 0.896 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.408056e-01 0.851 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.189495e-01 0.925 0 0
Semaphorin interactions R-HSA-373755 1.121754e-01 0.950 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.043362e-01 0.982 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 1.238111e-01 0.907 0 0
Oncogene Induced Senescence R-HSA-2559585 1.385123e-01 0.859 0 0
Maturation of nucleoprotein R-HSA-9694631 9.962745e-02 1.002 0 0
Tandem pore domain potassium channels R-HSA-1296346 1.466889e-01 0.834 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 1.293930e-01 0.888 0 0
Signaling by NTRKs R-HSA-166520 1.271551e-01 0.896 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 1.271864e-01 0.896 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.052906e-01 0.978 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 1.271864e-01 0.896 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.421393e-01 0.847 0 0
Signaling by NOTCH3 R-HSA-9012852 1.122181e-01 0.950 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 1.238111e-01 0.907 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.123472e-01 0.949 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.134254e-01 0.945 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.089244e-01 0.963 0 0
Translesion synthesis by POLI R-HSA-5656121 1.474346e-01 0.831 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.474346e-01 0.831 0 0
Phosphorylation of the APC/C R-HSA-176412 1.474346e-01 0.831 0 0
Prolonged ERK activation events R-HSA-169893 1.474346e-01 0.831 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 1.474346e-01 0.831 0 0
Regulation of BACH1 activity R-HSA-9708530 1.474346e-01 0.831 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.479790e-01 0.830 0 0
DARPP-32 events R-HSA-180024 1.481765e-01 0.829 0 0
IRE1alpha activates chaperones R-HSA-381070 1.521844e-01 0.818 0 0
DNA Replication R-HSA-69306 1.559235e-01 0.807 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.562312e-01 0.806 0 0
FGFR2 alternative splicing R-HSA-6803529 1.578121e-01 0.802 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 1.578121e-01 0.802 0 0
Signaling by ERBB2 R-HSA-1227986 1.578344e-01 0.802 0 0
Influenza Infection R-HSA-168255 1.584509e-01 0.800 0 0
Gene Silencing by RNA R-HSA-211000 1.586417e-01 0.800 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 1.589168e-01 0.799 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 1.589168e-01 0.799 0 0
IRS activation R-HSA-74713 1.589168e-01 0.799 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.589168e-01 0.799 0 0
Translation of Structural Proteins R-HSA-9694635 1.602495e-01 0.795 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.604478e-01 0.795 0 0
Neurexins and neuroligins R-HSA-6794361 1.604478e-01 0.795 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 1.604478e-01 0.795 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 1.620973e-01 0.790 0 0
Interleukin-37 signaling R-HSA-9008059 1.620973e-01 0.790 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 1.647175e-01 0.783 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.661638e-01 0.779 0 0
Signaling by Hedgehog R-HSA-5358351 1.662810e-01 0.779 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.663798e-01 0.779 0 0
Translesion synthesis by POLK R-HSA-5655862 1.663798e-01 0.779 0 0
Disorders of Developmental Biology R-HSA-9675151 1.663798e-01 0.779 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.663798e-01 0.779 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 1.663798e-01 0.779 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.708063e-01 0.767 0 0
PECAM1 interactions R-HSA-210990 1.708063e-01 0.767 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.738458e-01 0.760 0 0
Syndecan interactions R-HSA-3000170 1.741525e-01 0.759 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.742155e-01 0.759 0 0
L1CAM interactions R-HSA-373760 1.758911e-01 0.755 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.761677e-01 0.754 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.765537e-01 0.753 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.783118e-01 0.749 0 0
Pyruvate metabolism R-HSA-70268 1.823703e-01 0.739 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.833817e-01 0.737 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.833817e-01 0.737 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.833817e-01 0.737 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.833817e-01 0.737 0 0
Neutrophil degranulation R-HSA-6798695 1.858808e-01 0.731 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.861320e-01 0.730 0 0
Signaling by Hippo R-HSA-2028269 1.861320e-01 0.730 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 1.861320e-01 0.730 0 0
Specification of primordial germ cells R-HSA-9827857 1.861320e-01 0.730 0 0
Regulation of pyruvate metabolism R-HSA-9861718 1.864399e-01 0.729 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.881004e-01 0.726 0 0
Signaling by PTK6 R-HSA-8848021 1.889899e-01 0.724 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.889899e-01 0.724 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 1.896034e-01 0.722 0 0
Deadenylation of mRNA R-HSA-429947 1.911052e-01 0.719 0 0
Neurodegenerative Diseases R-HSA-8863678 1.911052e-01 0.719 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.911052e-01 0.719 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.941181e-01 0.712 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 1.948922e-01 0.710 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.948922e-01 0.710 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.948922e-01 0.710 0 0
Phosphorylation of Emi1 R-HSA-176417 1.948922e-01 0.710 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 1.948922e-01 0.710 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.948922e-01 0.710 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 1.948922e-01 0.710 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 1.948922e-01 0.710 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.948922e-01 0.710 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.948922e-01 0.710 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 1.959521e-01 0.708 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 1.959521e-01 0.708 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 2.620541e-01 0.582 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.620541e-01 0.582 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.620541e-01 0.582 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 2.620541e-01 0.582 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.620541e-01 0.582 0 0
Defective SLC26A2 causes chondrodysplasias R-HSA-3560792 2.620541e-01 0.582 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 2.620541e-01 0.582 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.331514e-01 0.477 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.331514e-01 0.477 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 3.331514e-01 0.477 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.331514e-01 0.477 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.331514e-01 0.477 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 3.331514e-01 0.477 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 3.331514e-01 0.477 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 3.331514e-01 0.477 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.317445e-01 0.635 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 2.317445e-01 0.635 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 2.317445e-01 0.635 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 2.689714e-01 0.570 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.689714e-01 0.570 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 2.689714e-01 0.570 0 0
SOS-mediated signalling R-HSA-112412 2.689714e-01 0.570 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 2.689714e-01 0.570 0 0
DAG1 core M1 glycosylations R-HSA-8932506 2.689714e-01 0.570 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.689714e-01 0.570 0 0
Axonal growth stimulation R-HSA-209563 3.974026e-01 0.401 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 3.974026e-01 0.401 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 3.974026e-01 0.401 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 3.974026e-01 0.401 0 0
MET activates PTPN11 R-HSA-8865999 3.974026e-01 0.401 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 3.974026e-01 0.401 0 0
Classical Kir channels R-HSA-1296053 3.974026e-01 0.401 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 3.061591e-01 0.514 0 0
DAG1 core M2 glycosylations R-HSA-8932504 3.061591e-01 0.514 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.061591e-01 0.514 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.061591e-01 0.514 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 2.485174e-01 0.605 0 0
PKA activation in glucagon signalling R-HSA-164378 2.065922e-01 0.685 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.276604e-01 0.643 0 0
ARMS-mediated activation R-HSA-170984 3.429697e-01 0.465 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 3.429697e-01 0.465 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 3.429697e-01 0.465 0 0
ALK mutants bind TKIs R-HSA-9700645 3.429697e-01 0.465 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.492368e-01 0.603 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 2.492368e-01 0.603 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 3.028652e-01 0.519 0 0
Binding and entry of HIV virion R-HSA-173107 3.791311e-01 0.421 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 3.791311e-01 0.421 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.935246e-01 0.532 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.935246e-01 0.532 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.160482e-01 0.500 0 0
Degradation of AXIN R-HSA-4641257 2.895409e-01 0.538 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.849010e-01 0.415 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.849010e-01 0.415 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 3.849010e-01 0.415 0 0
Trafficking of AMPA receptors R-HSA-399719 3.219237e-01 0.492 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 3.614154e-01 0.442 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 2.932189e-01 0.533 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 2.462799e-01 0.609 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 2.807062e-01 0.552 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.807062e-01 0.552 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 3.090256e-01 0.510 0 0
Long-term potentiation R-HSA-9620244 3.840971e-01 0.416 0 0
Integrin signaling R-HSA-354192 3.614099e-01 0.442 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 3.249900e-01 0.488 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 3.249900e-01 0.488 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.812199e-01 0.419 0 0
Nucleotide Excision Repair R-HSA-5696398 3.023366e-01 0.520 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 2.524430e-01 0.598 0 0
Repression of WNT target genes R-HSA-4641265 2.219211e-01 0.654 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 2.776012e-01 0.557 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.832631e-01 0.548 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.832631e-01 0.548 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.776012e-01 0.557 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 2.086124e-01 0.681 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 3.028652e-01 0.519 0 0
Regulation of the apoptosome activity R-HSA-9627069 3.791311e-01 0.421 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 3.597521e-01 0.444 0 0
Formation of apoptosome R-HSA-111458 3.791311e-01 0.421 0 0
Regulation of CDH11 function R-HSA-9762292 3.791311e-01 0.421 0 0
Regulation of Apoptosis R-HSA-169911 2.555579e-01 0.593 0 0
DNA Damage Bypass R-HSA-73893 2.251517e-01 0.648 0 0
Signaling by FGFR1 R-HSA-5654736 3.245004e-01 0.489 0 0
Formation of definitive endoderm R-HSA-9823730 2.492368e-01 0.603 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.216914e-01 0.493 0 0
p75NTR regulates axonogenesis R-HSA-193697 3.429697e-01 0.465 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 2.895409e-01 0.538 0 0
Orc1 removal from chromatin R-HSA-68949 2.664651e-01 0.574 0 0
Cyclin D associated events in G1 R-HSA-69231 2.776012e-01 0.557 0 0
G1 Phase R-HSA-69236 2.776012e-01 0.557 0 0
Degradation of CDH1 R-HSA-9766229 2.251517e-01 0.648 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.693872e-01 0.433 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 3.061591e-01 0.514 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 3.061591e-01 0.514 0 0
Termination of translesion DNA synthesis R-HSA-5656169 2.829823e-01 0.548 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.470582e-01 0.607 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.023564e-01 0.519 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.834105e-01 0.548 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 3.597521e-01 0.444 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 3.597521e-01 0.444 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 2.824515e-01 0.549 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.614154e-01 0.442 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.609549e-01 0.583 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.511820e-01 0.454 0 0
Integration of energy metabolism R-HSA-163685 2.938716e-01 0.532 0 0
Frs2-mediated activation R-HSA-170968 2.485174e-01 0.605 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.429697e-01 0.465 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 2.389935e-01 0.622 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.087485e-01 0.510 0 0
Neurofascin interactions R-HSA-447043 2.317445e-01 0.635 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.317445e-01 0.635 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 2.581815e-01 0.588 0 0
Signaling by WNT in cancer R-HSA-4791275 3.416267e-01 0.466 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.429697e-01 0.465 0 0
Vesicle-mediated transport R-HSA-5653656 3.013674e-01 0.521 0 0
Ion homeostasis R-HSA-5578775 3.245004e-01 0.489 0 0
S Phase R-HSA-69242 2.477629e-01 0.606 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.497720e-01 0.602 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 3.009309e-01 0.522 0 0
G0 and Early G1 R-HSA-1538133 3.416267e-01 0.466 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.620541e-01 0.582 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 3.331514e-01 0.477 0 0
Interleukin-33 signaling R-HSA-9014843 3.331514e-01 0.477 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.689714e-01 0.570 0 0
MET interacts with TNS proteins R-HSA-8875513 3.974026e-01 0.401 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 2.485174e-01 0.605 0 0
Unwinding of DNA R-HSA-176974 3.429697e-01 0.465 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 3.791311e-01 0.421 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 2.638603e-01 0.579 0 0
MET promotes cell motility R-HSA-8875878 3.068752e-01 0.513 0 0
Recycling pathway of L1 R-HSA-437239 3.249900e-01 0.488 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 2.610286e-01 0.583 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.094772e-01 0.509 0 0
Adaptive Immune System R-HSA-1280218 3.254961e-01 0.487 0 0
Signaling by FGFR R-HSA-190236 3.153422e-01 0.501 0 0
Rab regulation of trafficking R-HSA-9007101 2.599592e-01 0.585 0 0
Platelet degranulation R-HSA-114608 2.773948e-01 0.557 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 2.064290e-01 0.685 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 2.032453e-01 0.692 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.614099e-01 0.442 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 3.420214e-01 0.466 0 0
TCR signaling R-HSA-202403 3.563624e-01 0.448 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 3.208315e-01 0.494 0 0
Signal attenuation R-HSA-74749 3.791311e-01 0.421 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 3.576750e-01 0.447 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 1.990178e-01 0.701 0 0
Nef and signal transduction R-HSA-164944 2.317445e-01 0.635 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.689714e-01 0.570 0 0
CHL1 interactions R-HSA-447041 2.689714e-01 0.570 0 0
Disorders of Nervous System Development R-HSA-9697154 2.219211e-01 0.654 0 0
Pervasive developmental disorders R-HSA-9005895 2.219211e-01 0.654 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.219211e-01 0.654 0 0
Regulated proteolysis of p75NTR R-HSA-193692 3.429697e-01 0.465 0 0
Protein hydroxylation R-HSA-9629569 2.492368e-01 0.603 0 0
Vpu mediated degradation of CD4 R-HSA-180534 3.812199e-01 0.419 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.638603e-01 0.579 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.829823e-01 0.548 0 0
Signaling by NOTCH4 R-HSA-9013694 2.150797e-01 0.667 0 0
Signaling by FGFR2 R-HSA-5654738 2.834105e-01 0.548 0 0
MAP kinase activation R-HSA-450294 2.691532e-01 0.570 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 2.622039e-01 0.581 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.317445e-01 0.635 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 3.974026e-01 0.401 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 2.276604e-01 0.643 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.429697e-01 0.465 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.302863e-01 0.481 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 2.483987e-01 0.605 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.208315e-01 0.494 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.016356e-01 0.695 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.788685e-01 0.555 0 0
Interleukin-17 signaling R-HSA-448424 3.935001e-01 0.405 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 3.095554e-01 0.509 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.390021e-01 0.622 0 0
Cellular response to hypoxia R-HSA-1234174 3.233213e-01 0.490 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 3.055490e-01 0.515 0 0
Histamine receptors R-HSA-390650 3.974026e-01 0.401 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.160482e-01 0.500 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.462799e-01 0.609 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 3.179689e-01 0.498 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.429697e-01 0.465 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.791311e-01 0.421 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 2.638603e-01 0.579 0 0
RET signaling R-HSA-8853659 2.724211e-01 0.565 0 0
Interleukin-7 signaling R-HSA-1266695 2.086124e-01 0.681 0 0
Sensory processing of sound R-HSA-9659379 3.877491e-01 0.411 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.712234e-01 0.567 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 2.157062e-01 0.666 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.450508e-01 0.611 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.061591e-01 0.514 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.429697e-01 0.465 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 3.028652e-01 0.519 0 0
Nephron development R-HSA-9831926 2.065922e-01 0.685 0 0
Suppression of phagosomal maturation R-HSA-9637687 2.266145e-01 0.645 0 0
PI3K Cascade R-HSA-109704 3.735206e-01 0.428 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 3.411891e-01 0.467 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 2.829823e-01 0.548 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 3.245004e-01 0.489 0 0
Stimuli-sensing channels R-HSA-2672351 3.345096e-01 0.476 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 2.935246e-01 0.532 0 0
Signaling by Leptin R-HSA-2586552 3.791311e-01 0.421 0 0
Selenoamino acid metabolism R-HSA-2408522 3.876673e-01 0.412 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 3.995983e-01 0.398 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 4.010059e-01 0.397 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 4.010059e-01 0.397 0 0
Calnexin/calreticulin cycle R-HSA-901042 4.010059e-01 0.397 0 0
Mitophagy R-HSA-5205647 4.010059e-01 0.397 0 0
PKR-mediated signaling R-HSA-9833482 4.011149e-01 0.397 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.061068e-01 0.391 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 4.066783e-01 0.391 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 4.066783e-01 0.391 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 4.076696e-01 0.390 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 4.118483e-01 0.385 0 0
Apoptotic factor-mediated response R-HSA-111471 4.118483e-01 0.385 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 4.118483e-01 0.385 0 0
HIV Life Cycle R-HSA-162587 4.118883e-01 0.385 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 4.131093e-01 0.384 0 0
Signaling by FGFR4 R-HSA-5654743 4.131093e-01 0.384 0 0
Signaling by SCF-KIT R-HSA-1433557 4.131093e-01 0.384 0 0
Response of Mtb to phagocytosis R-HSA-9637690 4.131093e-01 0.384 0 0
Unfolded Protein Response (UPR) R-HSA-381119 4.141581e-01 0.383 0 0
LGI-ADAM interactions R-HSA-5682910 4.144267e-01 0.383 0 0
Synthesis of PI R-HSA-1483226 4.144267e-01 0.383 0 0
Cardiac conduction R-HSA-5576891 4.204850e-01 0.376 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 4.207195e-01 0.376 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 4.207195e-01 0.376 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 4.207195e-01 0.376 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 4.207195e-01 0.376 0 0
Signalling to ERKs R-HSA-187687 4.207195e-01 0.376 0 0
Regulation of PTEN stability and activity R-HSA-8948751 4.223838e-01 0.374 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 4.223838e-01 0.374 0 0
HCMV Early Events R-HSA-9609690 4.245548e-01 0.372 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 4.255380e-01 0.371 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 4.255380e-01 0.371 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 4.255380e-01 0.371 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.290915e-01 0.367 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 4.290915e-01 0.367 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 4.330882e-01 0.363 0 0
Ca2+ pathway R-HSA-4086398 4.359926e-01 0.361 1 1
Impaired BRCA2 binding to PALB2 R-HSA-9709603 4.384141e-01 0.358 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 4.384141e-01 0.358 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.384141e-01 0.358 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 4.386142e-01 0.358 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.386142e-01 0.358 0 0
Signaling by Interleukins R-HSA-449147 4.388305e-01 0.358 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 4.403154e-01 0.356 0 0
Signaling by TGFB family members R-HSA-9006936 4.404660e-01 0.356 0 0
Ion channel transport R-HSA-983712 4.481932e-01 0.349 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 4.484588e-01 0.348 0 0
Signaling by FGFR3 R-HSA-5654741 4.484588e-01 0.348 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.486878e-01 0.348 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 4.486878e-01 0.348 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 4.486878e-01 0.348 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 4.486878e-01 0.348 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 4.486878e-01 0.348 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.486878e-01 0.348 0 0
G1/S Transition R-HSA-69206 4.487132e-01 0.348 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 4.512745e-01 0.346 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 4.512745e-01 0.346 0 0
Formation of the Early Elongation Complex R-HSA-113418 4.512745e-01 0.346 0 0
Insulin receptor recycling R-HSA-77387 4.512745e-01 0.346 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.554667e-01 0.342 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.554667e-01 0.342 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.554667e-01 0.342 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.554667e-01 0.342 0 0
Regulation of gap junction activity R-HSA-191650 4.554667e-01 0.342 0 0
Alanine metabolism R-HSA-8964540 4.554667e-01 0.342 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.554667e-01 0.342 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 4.554667e-01 0.342 0 0
Sensory perception of sour taste R-HSA-9729555 4.554667e-01 0.342 0 0
Mitochondrial biogenesis R-HSA-1592230 4.565559e-01 0.341 0 0
Interleukin-1 family signaling R-HSA-446652 4.571194e-01 0.340 0 0
Signaling by Insulin receptor R-HSA-74752 4.584429e-01 0.339 0 0
Degradation of DVL R-HSA-4641258 4.597510e-01 0.337 0 0
Interleukin-1 signaling R-HSA-9020702 4.618660e-01 0.335 0 0
Cellular response to chemical stress R-HSA-9711123 4.635127e-01 0.334 0 0
Iron uptake and transport R-HSA-917937 4.641766e-01 0.333 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 4.645089e-01 0.333 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 4.645089e-01 0.333 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 4.645089e-01 0.333 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 4.645089e-01 0.333 0 0
Signal transduction by L1 R-HSA-445144 4.645089e-01 0.333 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 4.659674e-01 0.332 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.708338e-01 0.327 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 4.731710e-01 0.325 0 0
mRNA Capping R-HSA-72086 4.731710e-01 0.325 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 4.731710e-01 0.325 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 4.789868e-01 0.320 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 4.817862e-01 0.317 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.817862e-01 0.317 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.817862e-01 0.317 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 4.817862e-01 0.317 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 4.817862e-01 0.317 0 0
Regulation of IFNG signaling R-HSA-877312 4.817862e-01 0.317 0 0
Signaling by LTK R-HSA-9842663 4.817862e-01 0.317 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 4.817862e-01 0.317 0 0
IRS-mediated signalling R-HSA-112399 4.867752e-01 0.313 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 4.900557e-01 0.310 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 4.900557e-01 0.310 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.947302e-01 0.306 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 4.947302e-01 0.306 0 0
Translation R-HSA-72766 4.952453e-01 0.305 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 4.979864e-01 0.303 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 4.979864e-01 0.303 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 4.979864e-01 0.303 0 0
RAS processing R-HSA-9648002 4.979864e-01 0.303 1 1
Plasma lipoprotein clearance R-HSA-8964043 4.979864e-01 0.303 0 0
Co-stimulation by CD28 R-HSA-389356 5.005044e-01 0.301 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 5.025746e-01 0.299 0 0
Regulated Necrosis R-HSA-5218859 5.043458e-01 0.297 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.079389e-01 0.294 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.079389e-01 0.294 0 0
FGFR1c and Klotho ligand binding and activation R-HSA-190374 5.079389e-01 0.294 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 5.079389e-01 0.294 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.079389e-01 0.294 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.079389e-01 0.294 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 5.079389e-01 0.294 0 0
Reelin signalling pathway R-HSA-8866376 5.079389e-01 0.294 0 0
Pyrophosphate hydrolysis R-HSA-71737 5.079389e-01 0.294 0 0
Interleukin-36 pathway R-HSA-9014826 5.079389e-01 0.294 0 0
Co-inhibition by BTLA R-HSA-9927353 5.079389e-01 0.294 0 0
NrCAM interactions R-HSA-447038 5.079389e-01 0.294 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.079389e-01 0.294 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 5.079389e-01 0.294 0 0
Platelet activation, signaling and aggregation R-HSA-76002 5.086219e-01 0.294 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 5.136279e-01 0.289 0 0
Processing of SMDT1 R-HSA-8949664 5.136279e-01 0.289 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 5.136279e-01 0.289 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 5.136279e-01 0.289 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 5.136279e-01 0.289 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 5.136279e-01 0.289 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 5.154437e-01 0.288 0 0
Downstream signal transduction R-HSA-186763 5.159065e-01 0.287 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 5.159065e-01 0.287 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.159065e-01 0.287 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 5.167162e-01 0.287 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 5.167162e-01 0.287 0 0
HIV Transcription Elongation R-HSA-167169 5.167162e-01 0.287 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 5.167162e-01 0.287 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 5.167162e-01 0.287 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 5.174791e-01 0.286 0 0
Peroxisomal protein import R-HSA-9033241 5.182114e-01 0.285 0 0
COPI-mediated anterograde transport R-HSA-6807878 5.209191e-01 0.283 0 0
MHC class II antigen presentation R-HSA-2132295 5.227656e-01 0.282 0 0
ER-Phagosome pathway R-HSA-1236974 5.331319e-01 0.273 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 5.351458e-01 0.272 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 5.392534e-01 0.268 0 0
Notch-HLH transcription pathway R-HSA-350054 5.392534e-01 0.268 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 5.392534e-01 0.268 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 5.392534e-01 0.268 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 5.441478e-01 0.264 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 5.441478e-01 0.264 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 5.441478e-01 0.264 0 0
Hydrolysis of LPC R-HSA-1483115 5.441478e-01 0.264 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.441478e-01 0.264 0 0
cGMP effects R-HSA-418457 5.441478e-01 0.264 1 1
Signal regulatory protein family interactions R-HSA-391160 5.441478e-01 0.264 0 0
Regulation of insulin secretion R-HSA-422356 5.453118e-01 0.263 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.489204e-01 0.260 0 0
Hedgehog ligand biogenesis R-HSA-5358346 5.507213e-01 0.259 0 0
Degradation of CRY and PER proteins R-HSA-9932298 5.532479e-01 0.257 0 0
Plus-strand DNA synthesis R-HSA-164525 5.553577e-01 0.255 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.553577e-01 0.255 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.553577e-01 0.255 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.553577e-01 0.255 0 0
Signaling by MST1 R-HSA-8852405 5.553577e-01 0.255 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 5.553577e-01 0.255 0 0
Cam-PDE 1 activation R-HSA-111957 5.553577e-01 0.255 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 5.553577e-01 0.255 0 0
Synthesis of PS R-HSA-1483101 5.553577e-01 0.255 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 5.553577e-01 0.255 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 5.553577e-01 0.255 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 5.553577e-01 0.255 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.553577e-01 0.255 0 0
VEGF ligand-receptor interactions R-HSA-194313 5.553577e-01 0.255 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 5.553577e-01 0.255 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 5.553577e-01 0.255 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 5.553577e-01 0.255 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 5.564138e-01 0.255 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 5.569553e-01 0.254 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 5.569553e-01 0.254 0 0
Activation of ATR in response to replication stress R-HSA-176187 5.569553e-01 0.254 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 5.569553e-01 0.254 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 5.616778e-01 0.251 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 5.628051e-01 0.250 0 0
Interleukin receptor SHC signaling R-HSA-912526 5.628051e-01 0.250 0 0
Growth hormone receptor signaling R-HSA-982772 5.628051e-01 0.250 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.639579e-01 0.249 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 5.669468e-01 0.246 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 5.678251e-01 0.246 0 0
Erythropoietin activates RAS R-HSA-9027284 5.733049e-01 0.242 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 5.733049e-01 0.242 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 5.733049e-01 0.242 0 0
DNA Damage Reversal R-HSA-73942 5.733049e-01 0.242 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 5.733049e-01 0.242 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 5.733049e-01 0.242 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 5.733049e-01 0.242 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.733049e-01 0.242 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 5.767625e-01 0.239 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 5.767625e-01 0.239 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 5.849696e-01 0.233 1 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 5.856083e-01 0.232 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 5.856083e-01 0.232 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 5.856083e-01 0.232 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 5.856083e-01 0.232 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 5.882594e-01 0.230 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 5.882594e-01 0.230 0 0
TBC/RABGAPs R-HSA-8854214 5.883741e-01 0.230 0 0
IGF1R signaling cascade R-HSA-2428924 5.933217e-01 0.227 0 0
Insulin receptor signalling cascade R-HSA-74751 5.933217e-01 0.227 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 5.949272e-01 0.226 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 5.960560e-01 0.225 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 5.960560e-01 0.225 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 5.960560e-01 0.225 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 5.960560e-01 0.225 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 5.982094e-01 0.223 0 0
Signaling by LTK in cancer R-HSA-9842640 5.982094e-01 0.223 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.982094e-01 0.223 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 5.982094e-01 0.223 0 0
STAT5 Activation R-HSA-9645135 5.982094e-01 0.223 0 0
Uncoating of the HIV Virion R-HSA-162585 5.982094e-01 0.223 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 5.982094e-01 0.223 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 5.982094e-01 0.223 0 0
Hydrolysis of LPE R-HSA-1483152 5.982094e-01 0.223 0 0
CREB phosphorylation R-HSA-199920 5.982094e-01 0.223 0 0
Lipid particle organization R-HSA-8964572 5.982094e-01 0.223 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 6.010785e-01 0.221 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.010785e-01 0.221 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.010785e-01 0.221 0 0
Netrin-1 signaling R-HSA-373752 6.053577e-01 0.218 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 6.076211e-01 0.216 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 6.076360e-01 0.216 0 0
TGFBR3 expression R-HSA-9839394 6.076360e-01 0.216 0 0
Tight junction interactions R-HSA-420029 6.076360e-01 0.216 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 6.122207e-01 0.213 0 0
Transferrin endocytosis and recycling R-HSA-917977 6.148147e-01 0.211 0 0
UCH proteinases R-HSA-5689603 6.159448e-01 0.210 0 0
SARS-CoV-2-host interactions R-HSA-9705683 6.163955e-01 0.210 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 6.197961e-01 0.208 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 6.197961e-01 0.208 0 0
Organelle biogenesis and maintenance R-HSA-1852241 6.212979e-01 0.207 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 6.219323e-01 0.206 0 0
Fanconi Anemia Pathway R-HSA-6783310 6.219323e-01 0.206 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 6.219323e-01 0.206 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 6.219323e-01 0.206 0 0
RSV-host interactions R-HSA-9833110 6.266209e-01 0.203 0 0
Adipogenesis R-HSA-9843745 6.269297e-01 0.203 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 6.274644e-01 0.202 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 6.274644e-01 0.202 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.274644e-01 0.202 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.274644e-01 0.202 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 6.274644e-01 0.202 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 6.274644e-01 0.202 0 0
Coenzyme A biosynthesis R-HSA-196783 6.274644e-01 0.202 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 6.274644e-01 0.202 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 6.288076e-01 0.201 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 6.288686e-01 0.201 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 6.288686e-01 0.201 0 0
TRP channels R-HSA-3295583 6.288686e-01 0.201 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.369335e-01 0.196 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.369335e-01 0.196 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.369335e-01 0.196 0 0
Disinhibition of SNARE formation R-HSA-114516 6.369335e-01 0.196 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.369335e-01 0.196 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.369335e-01 0.196 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 6.369335e-01 0.196 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.369335e-01 0.196 0 0
VLDL clearance R-HSA-8964046 6.369335e-01 0.196 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 6.369335e-01 0.196 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.369335e-01 0.196 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 6.376191e-01 0.195 0 0
Diseases of DNA repair R-HSA-9675135 6.380844e-01 0.195 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.389969e-01 0.195 0 0
Host Interactions of HIV factors R-HSA-162909 6.401542e-01 0.194 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.422863e-01 0.192 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 6.492935e-01 0.188 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 6.492935e-01 0.188 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 6.492935e-01 0.188 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 6.492935e-01 0.188 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 6.492935e-01 0.188 0 0
Late Phase of HIV Life Cycle R-HSA-162599 6.523511e-01 0.186 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 6.523511e-01 0.186 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 6.524722e-01 0.185 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 6.524722e-01 0.185 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 6.524722e-01 0.185 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.524722e-01 0.185 0 0
Uptake and function of anthrax toxins R-HSA-5210891 6.524722e-01 0.185 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 6.542091e-01 0.184 0 0
Dual incision in TC-NER R-HSA-6782135 6.577283e-01 0.182 0 0
Protein localization R-HSA-9609507 6.580443e-01 0.182 0 0
HIV elongation arrest and recovery R-HSA-167287 6.689041e-01 0.175 0 0
Pausing and recovery of HIV elongation R-HSA-167290 6.689041e-01 0.175 0 0
Gluconeogenesis R-HSA-70263 6.690776e-01 0.175 0 0
Antigen processing-Cross presentation R-HSA-1236975 6.695550e-01 0.174 0 0
Downstream TCR signaling R-HSA-202424 6.709419e-01 0.173 0 0
snRNP Assembly R-HSA-191859 6.716517e-01 0.173 0 0
Metabolism of non-coding RNA R-HSA-194441 6.716517e-01 0.173 0 0
Reverse Transcription of HIV RNA R-HSA-162589 6.719276e-01 0.173 0 0
Minus-strand DNA synthesis R-HSA-164516 6.719276e-01 0.173 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 6.719276e-01 0.173 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 6.719276e-01 0.173 0 0
phospho-PLA2 pathway R-HSA-111995 6.719276e-01 0.173 0 0
MET receptor recycling R-HSA-8875656 6.719276e-01 0.173 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.719276e-01 0.173 0 0
FGFR1b ligand binding and activation R-HSA-190370 6.719276e-01 0.173 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 6.719276e-01 0.173 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 6.719276e-01 0.173 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 6.719276e-01 0.173 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.719276e-01 0.173 0 0
GAB1 signalosome R-HSA-180292 6.761222e-01 0.170 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.761222e-01 0.170 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.761222e-01 0.170 0 0
FGFR1 ligand binding and activation R-HSA-190242 6.761222e-01 0.170 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 6.761222e-01 0.170 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 6.761222e-01 0.170 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 6.761222e-01 0.170 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 6.842160e-01 0.165 0 0
Signaling by ALK R-HSA-201556 6.842160e-01 0.165 0 0
HIV Infection R-HSA-162906 6.853323e-01 0.164 0 0
Glycolysis R-HSA-70171 6.860402e-01 0.164 0 0
ABC-family proteins mediated transport R-HSA-382556 6.860402e-01 0.164 0 0
Signaling by Erythropoietin R-HSA-9006335 6.876991e-01 0.163 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 6.876991e-01 0.163 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 6.876991e-01 0.163 1 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 6.876991e-01 0.163 0 0
Platelet calcium homeostasis R-HSA-418360 6.876991e-01 0.163 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 6.899188e-01 0.161 0 0
MyD88-independent TLR4 cascade R-HSA-166166 6.899188e-01 0.161 0 0
ER to Golgi Anterograde Transport R-HSA-199977 6.967419e-01 0.157 0 0
The NLRP3 inflammasome R-HSA-844456 6.984439e-01 0.156 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.984439e-01 0.156 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.984439e-01 0.156 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 6.996722e-01 0.155 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.001172e-01 0.155 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.001172e-01 0.155 0 0
Generation of second messenger molecules R-HSA-202433 7.001172e-01 0.155 0 0
Interleukin-2 family signaling R-HSA-451927 7.001172e-01 0.155 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.035506e-01 0.153 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.035506e-01 0.153 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.035506e-01 0.153 0 0
WNT mediated activation of DVL R-HSA-201688 7.035506e-01 0.153 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.035506e-01 0.153 0 0
Interleukin-1 processing R-HSA-448706 7.035506e-01 0.153 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.035506e-01 0.153 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 7.035506e-01 0.153 0 0
Activation of the pre-replicative complex R-HSA-68962 7.056822e-01 0.151 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 7.056822e-01 0.151 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 7.056822e-01 0.151 0 0
Activation of BH3-only proteins R-HSA-114452 7.056822e-01 0.151 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 7.056822e-01 0.151 1 1
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 7.121863e-01 0.147 0 0
Cilium Assembly R-HSA-5617833 7.122791e-01 0.147 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 7.154334e-01 0.145 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 7.194736e-01 0.143 0 0
Co-inhibition by CTLA4 R-HSA-389513 7.194736e-01 0.143 0 0
Acyl chain remodelling of PI R-HSA-1482922 7.194736e-01 0.143 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 7.228610e-01 0.141 0 0
Molecules associated with elastic fibres R-HSA-2129379 7.228610e-01 0.141 0 0
Cargo concentration in the ER R-HSA-5694530 7.228610e-01 0.141 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 7.268823e-01 0.139 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 7.278940e-01 0.138 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.321272e-01 0.135 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 7.321272e-01 0.135 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 7.321272e-01 0.135 0 0
CASP4 inflammasome assembly R-HSA-9948001 7.321272e-01 0.135 0 0
Maturation of spike protein R-HSA-9683686 7.321272e-01 0.135 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 7.321272e-01 0.135 0 0
SARS-CoV-2 Infection R-HSA-9694516 7.341887e-01 0.134 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 7.344221e-01 0.134 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.348285e-01 0.134 0 0
Ion transport by P-type ATPases R-HSA-936837 7.356877e-01 0.133 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.392529e-01 0.131 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 7.392529e-01 0.131 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 7.392529e-01 0.131 0 0
Viral Infection Pathways R-HSA-9824446 7.402460e-01 0.131 0 0
Platelet homeostasis R-HSA-418346 7.543212e-01 0.122 1 0
G-protein beta:gamma signalling R-HSA-397795 7.548536e-01 0.122 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 7.548536e-01 0.122 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 7.548536e-01 0.122 0 0
Cardiogenesis R-HSA-9733709 7.548536e-01 0.122 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.578274e-01 0.120 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.578274e-01 0.120 0 0
Attachment and Entry R-HSA-9694614 7.578274e-01 0.120 0 0
Mitochondrial calcium ion transport R-HSA-8949215 7.578274e-01 0.120 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.579506e-01 0.120 0 0
DAG1 core M3 glycosylations R-HSA-8932505 7.579506e-01 0.120 0 0
Ionotropic activity of kainate receptors R-HSA-451306 7.579506e-01 0.120 0 0
vRNA Synthesis R-HSA-192814 7.579506e-01 0.120 0 0
vRNP Assembly R-HSA-192905 7.579506e-01 0.120 0 0
Bicarbonate transporters R-HSA-425381 7.579506e-01 0.120 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 7.579506e-01 0.120 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 7.579506e-01 0.120 0 0
Suppression of apoptosis R-HSA-9635465 7.579506e-01 0.120 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.579506e-01 0.120 0 0
Transport of RCbl within the body R-HSA-9758890 7.579506e-01 0.120 0 0
Interleukin-2 signaling R-HSA-9020558 7.579506e-01 0.120 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.579506e-01 0.120 0 0
Synthesis of DNA R-HSA-69239 7.631811e-01 0.117 0 0
Nuclear Receptor transcription pathway R-HSA-383280 7.662947e-01 0.116 0 0
Integrin cell surface interactions R-HSA-216083 7.662947e-01 0.116 0 0
ABC transporter disorders R-HSA-5619084 7.662947e-01 0.116 0 0
PCP/CE pathway R-HSA-4086400 7.662947e-01 0.116 0 0
HCMV Infection R-HSA-9609646 7.667121e-01 0.115 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 7.696986e-01 0.114 0 0
Resolution of D-Loop Structures R-HSA-5693537 7.696986e-01 0.114 0 0
Effects of PIP2 hydrolysis R-HSA-114508 7.696986e-01 0.114 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 7.696986e-01 0.114 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.696986e-01 0.114 0 0
Amine ligand-binding receptors R-HSA-375280 7.709149e-01 0.113 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 7.748952e-01 0.111 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.752455e-01 0.111 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 7.752455e-01 0.111 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 7.752455e-01 0.111 0 0
SARS-CoV Infections R-HSA-9679506 7.795572e-01 0.108 0 0
Transcription of the HIV genome R-HSA-167172 7.801298e-01 0.108 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.812860e-01 0.107 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 7.812860e-01 0.107 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 7.812860e-01 0.107 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 7.812860e-01 0.107 0 0
Plasmalogen biosynthesis R-HSA-75896 7.812860e-01 0.107 0 0
ERKs are inactivated R-HSA-202670 7.812860e-01 0.107 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 7.812860e-01 0.107 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 7.812860e-01 0.107 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 7.812860e-01 0.107 0 0
Sodium/Calcium exchangers R-HSA-425561 7.812860e-01 0.107 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 7.833737e-01 0.106 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 7.838007e-01 0.106 0 0
Nuclear import of Rev protein R-HSA-180746 7.838007e-01 0.106 0 0
eNOS activation R-HSA-203615 7.838007e-01 0.106 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 7.879262e-01 0.104 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.915575e-01 0.102 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.915575e-01 0.102 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 7.915575e-01 0.102 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.915575e-01 0.102 0 0
Toll-like Receptor Cascades R-HSA-168898 7.915832e-01 0.102 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 7.941593e-01 0.100 0 0
Signaling by TGFBR3 R-HSA-9839373 7.952871e-01 0.099 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.971806e-01 0.098 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 7.971806e-01 0.098 0 0
Potential therapeutics for SARS R-HSA-9679191 8.015566e-01 0.096 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 8.023729e-01 0.096 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 8.023729e-01 0.096 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.023729e-01 0.096 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.023729e-01 0.096 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.023729e-01 0.096 0 0
Estrogen biosynthesis R-HSA-193144 8.023729e-01 0.096 0 0
Interleukin-15 signaling R-HSA-8983432 8.023729e-01 0.096 0 0
OAS antiviral response R-HSA-8983711 8.023729e-01 0.096 0 0
PI Metabolism R-HSA-1483255 8.061150e-01 0.094 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.066671e-01 0.093 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 8.068147e-01 0.093 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 8.068147e-01 0.093 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.068147e-01 0.093 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.098605e-01 0.092 0 0
RNA Polymerase III Transcription R-HSA-74158 8.098605e-01 0.092 0 0
RUNX2 regulates bone development R-HSA-8941326 8.098605e-01 0.092 0 0
GPVI-mediated activation cascade R-HSA-114604 8.098605e-01 0.092 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.098605e-01 0.092 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 8.130459e-01 0.090 0 0
Circadian clock R-HSA-9909396 8.158246e-01 0.088 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.170717e-01 0.088 0 0
GPER1 signaling R-HSA-9634597 8.175264e-01 0.087 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.210689e-01 0.086 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.210689e-01 0.086 0 0
Laminin interactions R-HSA-3000157 8.210689e-01 0.086 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.210689e-01 0.086 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.214279e-01 0.085 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 8.214279e-01 0.085 0 0
Formation of axial mesoderm R-HSA-9796292 8.214279e-01 0.085 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.214279e-01 0.085 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.214279e-01 0.085 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 8.214279e-01 0.085 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.214279e-01 0.085 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.214279e-01 0.085 0 0
Interleukin-6 signaling R-HSA-1059683 8.214279e-01 0.085 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 8.218637e-01 0.085 0 0
Cytokine Signaling in Immune system R-HSA-1280215 8.221212e-01 0.085 0 0
Aquaporin-mediated transport R-HSA-445717 8.265627e-01 0.083 0 0
Gap junction trafficking and regulation R-HSA-157858 8.278788e-01 0.082 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.332142e-01 0.079 0 0
Elastic fibre formation R-HSA-1566948 8.332142e-01 0.079 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.332142e-01 0.079 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 8.332142e-01 0.079 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 8.343716e-01 0.079 0 0
Myogenesis R-HSA-525793 8.343716e-01 0.079 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.343716e-01 0.079 0 0
Sphingolipid catabolism R-HSA-9845614 8.343716e-01 0.079 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 8.343716e-01 0.079 0 0
Mitochondrial protein import R-HSA-1268020 8.356503e-01 0.078 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.377384e-01 0.077 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.386466e-01 0.076 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.386466e-01 0.076 0 0
Signaling by FGFR4 in disease R-HSA-5655291 8.386466e-01 0.076 0 0
Physiological factors R-HSA-5578768 8.386466e-01 0.076 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.386466e-01 0.076 0 0
Non-canonical inflammasome activation R-HSA-9686114 8.386466e-01 0.076 0 0
HDL assembly R-HSA-8963896 8.386466e-01 0.076 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.386466e-01 0.076 0 0
P2Y receptors R-HSA-417957 8.386466e-01 0.076 0 0
Zinc transporters R-HSA-435354 8.386466e-01 0.076 0 0
Pentose phosphate pathway R-HSA-71336 8.439365e-01 0.074 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.439365e-01 0.074 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.443443e-01 0.073 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.467736e-01 0.072 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 8.467736e-01 0.072 0 0
Insulin processing R-HSA-264876 8.467736e-01 0.072 0 0
Hemostasis R-HSA-109582 8.480188e-01 0.072 1 0
Chaperonin-mediated protein folding R-HSA-390466 8.522125e-01 0.069 0 0
Glucose metabolism R-HSA-70326 8.522509e-01 0.069 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 8.540556e-01 0.069 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 8.540556e-01 0.069 0 0
Diseases of Immune System R-HSA-5260271 8.540556e-01 0.069 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.540556e-01 0.069 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.542059e-01 0.068 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.542059e-01 0.068 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.542059e-01 0.068 0 0
Protein lipoylation R-HSA-9857492 8.542059e-01 0.068 0 0
Transport and metabolism of PAPS R-HSA-174362 8.542059e-01 0.068 0 0
p38MAPK events R-HSA-171007 8.542059e-01 0.068 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 8.542059e-01 0.068 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.566107e-01 0.067 0 0
Telomere Extension By Telomerase R-HSA-171319 8.583250e-01 0.066 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.583250e-01 0.066 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 8.583250e-01 0.066 0 0
Inflammasomes R-HSA-622312 8.583250e-01 0.066 0 0
Maturation of spike protein R-HSA-9694548 8.635966e-01 0.064 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 8.635966e-01 0.064 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 8.635966e-01 0.064 0 0
FOXO-mediated transcription R-HSA-9614085 8.665763e-01 0.062 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 8.682657e-01 0.061 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.682657e-01 0.061 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.682657e-01 0.061 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 8.682657e-01 0.061 0 0
Activation of SMO R-HSA-5635838 8.682657e-01 0.061 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 8.682657e-01 0.061 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 8.682657e-01 0.061 0 0
Attachment and Entry R-HSA-9678110 8.682657e-01 0.061 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.682657e-01 0.061 0 0
Differentiation of T cells R-HSA-9945266 8.682657e-01 0.061 0 0
Regulation of gene expression in beta cells R-HSA-210745 8.690744e-01 0.061 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.725843e-01 0.059 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 8.725843e-01 0.059 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 8.785252e-01 0.056 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.790691e-01 0.056 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 8.790691e-01 0.056 0 0
Inositol phosphate metabolism R-HSA-1483249 8.792699e-01 0.056 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 8.801793e-01 0.055 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 8.809704e-01 0.055 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.809704e-01 0.055 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 8.809704e-01 0.055 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 8.809704e-01 0.055 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 8.809704e-01 0.055 0 0
Glycine degradation R-HSA-6783984 8.809704e-01 0.055 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 8.809704e-01 0.055 0 0
Passive transport by Aquaporins R-HSA-432047 8.809704e-01 0.055 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.809704e-01 0.055 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 8.809704e-01 0.055 0 0
Interferon Signaling R-HSA-913531 8.822205e-01 0.054 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 8.858519e-01 0.053 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.883545e-01 0.051 0 0
Protein folding R-HSA-391251 8.901498e-01 0.051 0 0
Formation of the cornified envelope R-HSA-6809371 8.905463e-01 0.050 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 8.924505e-01 0.049 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 8.924505e-01 0.049 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 8.924505e-01 0.049 0 0
Sulfide oxidation to sulfate R-HSA-1614517 8.924505e-01 0.049 0 0
Catecholamine biosynthesis R-HSA-209905 8.924505e-01 0.049 0 0
Choline catabolism R-HSA-6798163 8.924505e-01 0.049 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.956014e-01 0.048 0 0
Surfactant metabolism R-HSA-5683826 8.964752e-01 0.047 0 0
Gap junction trafficking R-HSA-190828 8.964752e-01 0.047 0 0
DAG1 glycosylations R-HSA-8931838 8.969746e-01 0.047 0 0
DNA strand elongation R-HSA-69190 8.969746e-01 0.047 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.975215e-01 0.047 0 0
HCMV Late Events R-HSA-9610379 8.989967e-01 0.046 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.028240e-01 0.044 0 0
Synaptic adhesion-like molecules R-HSA-8849932 9.028240e-01 0.044 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.028240e-01 0.044 0 0
Mismatch Repair R-HSA-5358508 9.028240e-01 0.044 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.028240e-01 0.044 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.028240e-01 0.044 0 0
Neuronal System R-HSA-112316 9.067474e-01 0.043 0 0
Regulation of beta-cell development R-HSA-186712 9.068450e-01 0.042 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.068450e-01 0.042 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.100814e-01 0.041 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.120192e-01 0.040 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.121974e-01 0.040 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.121974e-01 0.040 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 9.121974e-01 0.040 0 0
Other interleukin signaling R-HSA-449836 9.121974e-01 0.040 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.123843e-01 0.040 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.123843e-01 0.040 0 0
RAB geranylgeranylation R-HSA-8873719 9.126297e-01 0.040 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.192521e-01 0.037 0 0
Signal amplification R-HSA-392518 9.192521e-01 0.037 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.192521e-01 0.037 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.192521e-01 0.037 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.206673e-01 0.036 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.206673e-01 0.036 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 9.206673e-01 0.036 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.206673e-01 0.036 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.206673e-01 0.036 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.219317e-01 0.035 0 0
Signaling by PDGF R-HSA-186797 9.232467e-01 0.035 0 0
tRNA processing in the nucleus R-HSA-6784531 9.232467e-01 0.035 0 0
Heme signaling R-HSA-9707616 9.232467e-01 0.035 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.237142e-01 0.034 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.256108e-01 0.034 0 0
G-protein activation R-HSA-202040 9.283205e-01 0.032 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.283205e-01 0.032 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.283205e-01 0.032 0 0
ERK/MAPK targets R-HSA-198753 9.283205e-01 0.032 0 0
Signalling to RAS R-HSA-167044 9.283205e-01 0.032 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.283205e-01 0.032 0 0
Triglyceride catabolism R-HSA-163560 9.314947e-01 0.031 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.314947e-01 0.031 0 0
Azathioprine ADME R-HSA-9748787 9.325328e-01 0.030 0 0
Neurotransmitter release cycle R-HSA-112310 9.345154e-01 0.029 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.352358e-01 0.029 0 0
Serine metabolism R-HSA-977347 9.352358e-01 0.029 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.352358e-01 0.029 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.352358e-01 0.029 0 0
The phototransduction cascade R-HSA-2514856 9.372749e-01 0.028 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.414844e-01 0.026 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.414844e-01 0.026 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.414844e-01 0.026 0 0
LDL clearance R-HSA-8964038 9.414844e-01 0.026 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.414844e-01 0.026 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.414844e-01 0.026 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.417072e-01 0.026 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 9.419657e-01 0.026 0 0
Extracellular matrix organization R-HSA-1474244 9.427102e-01 0.026 0 0
Interferon gamma signaling R-HSA-877300 9.442708e-01 0.025 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.448899e-01 0.025 0 0
Kidney development R-HSA-9830369 9.448899e-01 0.025 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.449892e-01 0.025 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.458475e-01 0.024 0 0
Nucleotide biosynthesis R-HSA-8956320 9.458475e-01 0.024 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.466122e-01 0.024 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 9.466122e-01 0.024 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.471304e-01 0.024 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.471304e-01 0.024 0 0
Biosynthesis of maresins R-HSA-9018682 9.471304e-01 0.024 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 9.471304e-01 0.024 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.471304e-01 0.024 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.471304e-01 0.024 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.471304e-01 0.024 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.471304e-01 0.024 0 0
Carnitine shuttle R-HSA-200425 9.471304e-01 0.024 0 0
Transmission across Chemical Synapses R-HSA-112315 9.488268e-01 0.023 0 0
CYP2E1 reactions R-HSA-211999 9.522319e-01 0.021 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.522319e-01 0.021 0 0
Complex III assembly R-HSA-9865881 9.522319e-01 0.021 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.522319e-01 0.021 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.522319e-01 0.021 0 0
Interleukin-6 family signaling R-HSA-6783589 9.522319e-01 0.021 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.532192e-01 0.021 0 0
Neddylation R-HSA-8951664 9.533027e-01 0.021 0 0
Paracetamol ADME R-HSA-9753281 9.533199e-01 0.021 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.568415e-01 0.019 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.568415e-01 0.019 0 0
G protein gated Potassium channels R-HSA-1296059 9.568415e-01 0.019 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.568415e-01 0.019 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.568415e-01 0.019 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.568415e-01 0.019 0 0
Hyaluronan degradation R-HSA-2160916 9.568415e-01 0.019 0 0
ECM proteoglycans R-HSA-3000178 9.580150e-01 0.019 0 0
Intra-Golgi traffic R-HSA-6811438 9.585159e-01 0.018 0 0
Immune System R-HSA-168256 9.591319e-01 0.018 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.604315e-01 0.018 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 9.610065e-01 0.017 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.610065e-01 0.017 0 0
Urea cycle R-HSA-70635 9.610065e-01 0.017 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.610065e-01 0.017 0 0
Activation of GABAB receptors R-HSA-991365 9.618847e-01 0.017 0 0
GABA B receptor activation R-HSA-977444 9.618847e-01 0.017 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.618847e-01 0.017 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.627411e-01 0.016 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.631242e-01 0.016 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.631242e-01 0.016 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.638175e-01 0.016 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.647697e-01 0.016 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.647697e-01 0.016 0 0
Triglyceride biosynthesis R-HSA-75109 9.647697e-01 0.016 0 0
Synthesis of PE R-HSA-1483213 9.647697e-01 0.016 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.653232e-01 0.015 0 0
Triglyceride metabolism R-HSA-8979227 9.654618e-01 0.015 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.654618e-01 0.015 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.658919e-01 0.015 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.678510e-01 0.014 0 0
tRNA Aminoacylation R-HSA-379724 9.679944e-01 0.014 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.681700e-01 0.014 0 0
Pyrimidine salvage R-HSA-73614 9.681700e-01 0.014 0 0
Pyroptosis R-HSA-5620971 9.681700e-01 0.014 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.704862e-01 0.013 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.712423e-01 0.013 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.712423e-01 0.013 0 0
Glucagon-type ligand receptors R-HSA-420092 9.712423e-01 0.013 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 9.729124e-01 0.012 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.729124e-01 0.012 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.729124e-01 0.012 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 9.740182e-01 0.011 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.740182e-01 0.011 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.740182e-01 0.011 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.760345e-01 0.011 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 9.765263e-01 0.010 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 9.765263e-01 0.010 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.765263e-01 0.010 0 0
Metal ion SLC transporters R-HSA-425410 9.771999e-01 0.010 0 0
Parasite infection R-HSA-9664407 9.772901e-01 0.010 0 0
Leishmania phagocytosis R-HSA-9664417 9.772901e-01 0.010 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.772901e-01 0.010 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.787924e-01 0.009 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.787924e-01 0.009 0 0
HS-GAG degradation R-HSA-2024096 9.787924e-01 0.009 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.798641e-01 0.009 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.808399e-01 0.008 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 9.808399e-01 0.008 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.808399e-01 0.008 0 0
Complex IV assembly R-HSA-9864848 9.824240e-01 0.008 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 9.826898e-01 0.008 0 0
Heme degradation R-HSA-189483 9.826898e-01 0.008 0 0
Potassium Channels R-HSA-1296071 9.834078e-01 0.007 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.843612e-01 0.007 0 0
Hyaluronan metabolism R-HSA-2142845 9.843612e-01 0.007 0 0
COPII-mediated vesicle transport R-HSA-204005 9.852994e-01 0.006 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.858713e-01 0.006 0 0
PERK regulates gene expression R-HSA-381042 9.858713e-01 0.006 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.864202e-01 0.006 0 0
Metabolism of cofactors R-HSA-8978934 9.864202e-01 0.006 1 0
HS-GAG biosynthesis R-HSA-2022928 9.872357e-01 0.006 0 0
Glycosphingolipid transport R-HSA-9845576 9.872357e-01 0.006 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.872357e-01 0.006 0 0
G1/S-Specific Transcription R-HSA-69205 9.872357e-01 0.006 0 0
G alpha (z) signalling events R-HSA-418597 9.876142e-01 0.005 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.882975e-01 0.005 0 0
Voltage gated Potassium channels R-HSA-1296072 9.884684e-01 0.005 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.884684e-01 0.005 0 0
Lysine catabolism R-HSA-71064 9.884684e-01 0.005 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.885033e-01 0.005 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.886575e-01 0.005 0 0
Purine salvage R-HSA-74217 9.895821e-01 0.005 0 0
Extension of Telomeres R-HSA-180786 9.912989e-01 0.004 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.914974e-01 0.004 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.914974e-01 0.004 0 0
GABA receptor activation R-HSA-977443 9.920377e-01 0.003 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.920377e-01 0.003 0 0
Cholesterol biosynthesis R-HSA-191273 9.922576e-01 0.003 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 9.923187e-01 0.003 0 0
Viral Messenger RNA Synthesis R-HSA-168325 9.927149e-01 0.003 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.927149e-01 0.003 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.930607e-01 0.003 0 0
HIV Transcription Initiation R-HSA-167161 9.930607e-01 0.003 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.930607e-01 0.003 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.930607e-01 0.003 0 0
Mitochondrial protein degradation R-HSA-9837999 9.931551e-01 0.003 0 0
Collagen formation R-HSA-1474290 9.931551e-01 0.003 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.932808e-01 0.003 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.933357e-01 0.003 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.943367e-01 0.002 0 0
Gastrulation R-HSA-9758941 9.944528e-01 0.002 0 0
Leishmania infection R-HSA-9658195 9.945611e-01 0.002 0 0
Parasitic Infection Pathways R-HSA-9824443 9.945611e-01 0.002 0 0
Proteasome assembly R-HSA-9907900 9.948839e-01 0.002 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.948839e-01 0.002 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.953783e-01 0.002 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 9.953783e-01 0.002 0 0
Somitogenesis R-HSA-9824272 9.953783e-01 0.002 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.953783e-01 0.002 0 0
Disease R-HSA-1643685 9.954407e-01 0.002 0 0
Nicotinate metabolism R-HSA-196807 9.957408e-01 0.002 0 0
Synthesis of PC R-HSA-1483191 9.962283e-01 0.002 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.965256e-01 0.002 0 0
Interferon alpha/beta signaling R-HSA-909733 9.965256e-01 0.002 0 0
Intraflagellar transport R-HSA-5620924 9.965928e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.967499e-01 0.001 0 0
G alpha (s) signalling events R-HSA-418555 9.967983e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.969221e-01 0.001 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.969221e-01 0.001 0 0
Retinoid metabolism and transport R-HSA-975634 9.970308e-01 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.972196e-01 0.001 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.974884e-01 0.001 0 0
Aspirin ADME R-HSA-9749641 9.975229e-01 0.001 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.979506e-01 0.001 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.984287e-01 0.001 0 0
Innate Immune System R-HSA-168249 9.985673e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.986354e-01 0.001 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.988059e-01 0.001 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.988865e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.989279e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.989279e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.989942e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.990915e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.990915e-01 0.000 0 0
Keratinization R-HSA-6805567 9.991883e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.992587e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.993305e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.993305e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.993661e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.993958e-01 0.000 0 0
SLC transporter disorders R-HSA-5619102 9.994067e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.994497e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.995066e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.995259e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.995419e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.995543e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.995543e-01 0.000 0 0
tRNA processing R-HSA-72306 9.995553e-01 0.000 0 0
PPARA activates gene expression R-HSA-1989781 9.995617e-01 0.000 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.996229e-01 0.000 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.996716e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.996716e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.997034e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.997573e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.997804e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.997963e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.998301e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.998814e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.998979e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999356e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.999543e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999559e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999567e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999572e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999621e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999670e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999682e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999715e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999768e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999780e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999790e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999811e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999860e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999924e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999938e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999949e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999956e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999958e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999958e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999959e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999963e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999965e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999970e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999974e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999979e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999980e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999985e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999991e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999993e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999997e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999997e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999999e-01 0.000 1 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999999e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999999e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999999e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999999e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.999999e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999999e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999999e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 1 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways