ATR

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
O00213 S228 PSP APBB1 FE65 RIR LLFGMRNSAASDEDSSWATLsQGSPSYGSPEDTDSFWNPNA
O14757 S296 PSP CHEK1 CHK1 PRVtsGGVsEsPsGFsKHIQsNLDFsPVNsAssEENVKYss
O14757 S317 GPS6|SIGNOR|ELM|iPTMNet|PSP CHEK1 CHK1 NLDFsPVNsAssEENVKYsssQPEPRTGLsLWDtsPsYIDK
O14757 S345 GPS6|SIGNOR|ELM|iPTMNet|PSP CHEK1 CHK1 LsLWDtsPsYIDKLVQGISFsQPTCPDHMLLNSQLLGTPGS
O15360 S1449 GPS6|SIGNOR|PSP FANCA FAA FACA FANCH DPEVSAALQSRQQAAPDADLsQEPHLF______________
O43542 S225 SIGNOR|PSP XRCC3 GMARLVVIDSVAAPFRCEFDsQASAPRARHLQSLGATLREL
O43543 S247 PSP XRCC2 LCKAWQQLVKHRMFFSKQDDsQSSNQFSLVSRCLKSNSLKK
O60934 S343 SIGNOR|PSP NBN NBS NBS1 P95 CDPQGHPSTGLKtttPGPsLsQGVsVDEKLMPSAPVNTTTY
O60934 S615 PSP NBN NBS NBS1 P95 MDIETNDtFsDEAVPEssKIsQENEIGKKRELKEDSLWSAK
O75717 T826 SIGNOR|PSP WDHD1 AND1 LILAQKLSELAVEKAAELTAtQVEEEEEEEDFRKKLNAGYs
O75943 S646 GPS6|SIGNOR|PSP RAD17 R24L EESLGEPtQATVPETWSLPLsQNSASELPAsQPQPFSAQGD
O75943 S656 GPS6|SIGNOR|PSP RAD17 R24L TVPETWSLPLsQNSASELPAsQPQPFSAQGDMEENIIIEDy
O94880 S294 PSP PHF14 KIAA0783 KVLsRNsADDEELtNDsLtLsQsKsNEDsLILEKsQNWSSQ
O96017 T68 SIGNOR|PSP CHEK2 CDS1 CHK2 RAD53 NSsQSSHSSSGTLSsLETVStQELYsIPEDQEPEDQEPEEP
P04637 S15 SIGNOR|PSP TP53 P53 ______MEEPQsDPsVEPPLsQEtFsDLWKLLPENNVLsPL
P04637 S20 iPTMNet TP53 P53 _MEEPQsDPsVEPPLsQEtFsDLWKLLPENNVLsPLPsQAM
P04637 S37 iPTMNet|PSP TP53 P53 EtFsDLWKLLPENNVLsPLPsQAMDDLMLsPDDIEQWFtED
P04637 T18 iPTMNet TP53 P53 ___MEEPQsDPsVEPPLsQEtFsDLWKLLPENNVLsPLPsQ
P06748 S125 PSP NPM1 NPM GsGPVHIsGQHLVAVEEDAEsEDEEEEDVKLLsIsGKRsAP
P08047 S101 PSP SP1 TSFP1 SQGPSQSGGTGELDLTATQLsQGANGWQIISSSSGATPTSK
P09874 S179 SIGNOR|PSP PARP1 ADPRT PPOL HPGCFVKNREELGFRPEYsAsQLKGFsLLAtEDKEALKKQL
P15927 S174 PSP RPA2 REPA2 RPA32 RPA34 EFTTHILEVINAHMVLSKANsQPSAGRAPISNPGMSEAGNF
P15927 S33 SIGNOR|PSP RPA2 REPA2 RPA32 RPA34 sYGGAGGYtQsPGGFGsPAPsQAEKKSRARAQHIVPCTIsQ
P15927 S52 PSP RPA2 REPA2 RPA32 RPA34 PsQAEKKSRARAQHIVPCTIsQLLSATLVDEVFRIGNVEIs
P15927 S72 PSP RPA2 REPA2 RPA32 RPA34 sQLLSATLVDEVFRIGNVEIsQVTIVGIIRHAEKAPTNIVY
P15927 T21 PSP RPA2 REPA2 RPA32 RPA34 MWNsGFEsYGsssYGGAGGYtQsPGGFGsPAPsQAEKKSRA
P16104 S140 GPS6 H2AX H2AFX KtsAtVGPKAPSGGKKAtQAsQEy_________________
P16220 S107 SIGNOR|PSP CREB1 QISTIAEsEDsQEsVDsVTDsQKRREILsRRPsYRKILNDL
P23025 S173 SIGNOR|iPTMNet|PSP XPA XPAC CDLEKREPPLKFIVKKNPHHsQWGDMKLYLKLQIVKRSLEV
P23025 S196 SIGNOR|iPTMNet|PSP XPA XPAC GDMKLYLKLQIVKRSLEVWGsQEALEEAKEVRQENREKMKQ
P23508 S118 SIGNOR|PSP MCC RLQGTTIREEDEySELRsELsQsQHEVNEDSRSMDQDQTSV
P23508 S120 SIGNOR|PSP MCC QGTTIREEDEySELRsELsQsQHEVNEDSRSMDQDQTSVSI
P25205 S535 PSP MCM3 GDAMPLGSAVDILATDDPNFsQEDQQDTQIYEKHDNLLHGT
P27707 S74 PSP DCK PVARWCNVQstQDEFEELtMsQKNGGNVLQMMYEKPERWSF
P35568 S270 PSP IRS1 HETILEAMRAMSDEFRPRsKsQsssNCSNPISVPLRRHHLN
P38398 S1143 GPS6|SIGNOR|PSP BRCA1 RNF53 DFSPYLISDNLEQPMGSSHAsQVCSETPDDLLDDGEIKEDt
P38398 S1280 GPS6|SIGNOR|PSP BRCA1 RNF53 LLSLKNsLNDCsNQVILAKAsQEHHLsEETKCSASLFSSQC
P38398 S1387 GPS6|SIGNOR BRCA1 RNF53 EAASGCESETSVSEDCSGLSsQSDILTtQQRDTMQHNLIKL
P38398 S1423 GPS6|SIGNOR|ELM|iPTMNet|PSP BRCA1 RNF53 NLIKLQQEMAELEAVLEQHGsQPSNSYPSIISDSSALEDLR
P38398 S1457 GPS6|SIGNOR|ELM|iPTMNet|PSP BRCA1 RNF53 SALEDLRNPEQSTSEKAVLtsQKssEYPIsQNPEGLsADKF
P38398 S1524 GPS6|ELM|iPTMNet|PSP BRCA1 RNF53 LDDRWYMHSCsGSLQNRNyPsQEELIKVVDVEEQQLEEsGP
P38398 T1394 GPS6|SIGNOR BRCA1 RNF53 SETSVSEDCSGLSsQSDILTtQQRDTMQHNLIKLQQEMAEL
P39880 S1357 PSP CUX1 CUTL1 sCDGVEATEGPGsADTEEPKsQGEAEREEVPRPAEQTEPPP
P42771 S140 PSP CDKN2A CDKN2 MTS1 ELGHRDVARYLRAAAGGTRGsNHARIDAAEGPsDIPD____
P42771 S152 PSP CDKN2A CDKN2 MTS1 AAAGGTRGsNHARIDAAEGPsDIPD________________
P42771 S7 PSP CDKN2A CDKN2 MTS1 ______________MEPAAGssMEPSADWLATAAARGRVEE
P42771 S8 PSP CDKN2A CDKN2 MTS1 _____________MEPAAGssMEPSADWLATAAARGRVEEV
P49006 S71 PSP MARCKSL1 MLP MRP VNGtDEAAGATGDAIEPAPPsQGAEAKGEVPPKEtPKKKKK
P49591 S101 PSP SARS1 SARS SERS PENVLSFDDLTADALANLKVsQIKKVRLLIDEAILKCDAER
P49591 S241 PSP SARS1 SARS SERS IPIYTPFFMRKEVMQEVAQLsQFDEELyKVIGKGSEKSDDN
P49736 S108 GPS6|SIGNOR|PSP MCM2 BM28 CCNL1 CDCL1 KIAA0030 DAYEAEGLALDDEDVEELtAsQREAAERAMRQRDREAGRGL
P54132 T122 PSP BLM RECQ2 RECQL3 GGSKSLLPDFLQtPKEVVCTtQNtPtVKKSRDTALKKLEFs
P54132 T99 PSP BLM RECQ2 RECQL3 NTTNQQRVKDFFKNAPAGQEtQRGGSKSLLPDFLQtPKEVV
P55072 S784 PSP VCP HEL-220 HEL-S-70 QsRGFGsFRFPsGNQGGAGPsQGsGGGtGGsVYTEDNDDDL
P78527 S2612 PSP PRKDC HYRC HYRC1 DSDWRFRSTVLtPMFVEtQAsQGtLQtRtQEGsLSARWPVA
P78527 T2609 SIGNOR|PSP PRKDC HYRC HYRC1 YTIDSDWRFRSTVLtPMFVEtQAsQGtLQtRtQEGsLSARW
P78527 T2647 PSP PRKDC HYRC HYRC1 ARWPVAGQIRAtQQQHDFtLtQtADGRssFDWLTGsstDPL
Q00987 S407 GPS6|SIGNOR|ELM|iPTMNet|PSP MDM2 QSQESEDysQPSTSsSIIySsQEDVKEFEREEtQDKEEsVE
Q01094 S31 GPS6|SIGNOR|ELM|iPTMNet|PSP E2F1 RBBP3 PCAPALEALLGAGALRLLDSsQIVIISAAQDASAPPAPTGP
Q01844 T79 PSP EWSR1 EWS ATYGQTAYATSYGQPPTGYttPtAPQAYSQPVQGYGTGAYD
Q02952 S732 PSP AKAP12 AKAP250 QKADEAGKDKEtGtDGILAGsQEHDPGQGsssPEQAGsPTE
Q03164 S516 SIGNOR|PSP KMT2A ALL1 CXXC7 HRX HTRX MLL MLL1 TRX1 IQVLPEERsDtPEVHPPLPIsQsPENEsNDRRSRRYsVSER
Q12888 S166 PSP TP53BP1 KEEDTSGNTTHSLGAEDTASsQLGFGVLELsQsQDVEENTV
Q12888 S176 PSP TP53BP1 HSLGAEDTASsQLGFGVLELsQsQDVEENTVPYEVDKEQLQ
Q12888 S178 PSP TP53BP1 LGAEDTASsQLGFGVLELsQsQDVEENTVPYEVDKEQLQsV
Q12888 S452 PSP TP53BP1 ASTPISQSTPVFPPGSLPIPsQPQFSHDIFIPSPSLEEQSN
Q12888 S831 PSP TP53BP1 EYEGDLKsGtAEtEPVEQDssQPsLPLVRADDPLRLDQELQ
Q12888 T302 PSP TP53BP1 QELMEsGLQIQKsPEPEVLstQEDLFDQsNKtVssDGCstP
Q13098 S474 PSP GPS1 COPS1 CSN1 MLRAAVLRNQIHVKsPPREGsQGELtPANsQsRMstNM___
Q13263 S824 GPS6 TRIM28 KAP1 RNF96 TIF1B KFSAVLVEPPPMsLPGAGLssQELsGGPGDGP_________
Q13315 S1981 SIGNOR|PSP ATM YADKKSMDDQEKRSLAFEEGsQSTtIssLSEKsKEETGISL
Q13535 T1989 PSP ATR FRP1 VHQALIVLQKGVELCFPENEtPPEGKNMLIHGRAMLLVGRF
Q14191 S1141 SIGNOR|PSP WRN RECQ3 RECQL2 GSNISKKsIMVQsPEKAySSsQPVISAQEQETQIVLYGKLV
Q14676 S513 PSP MDC1 KIAA0170 NFBD1 GDsDDsVEADKssPGIHLERsQAsttVDINtQVEKEVPPGS
Q14683 S957 PSP SMC1A DXS423E KIAA0178 SB1.8 SMC1 SMC1L1 DIKLPLSKGtMDDIsQEEGssQGEDsVsGsQRIssIYAREA
Q14683 S966 GPS6|PSP SMC1A DXS423E KIAA0178 SB1.8 SMC1 SMC1L1 tMDDIsQEEGssQGEDsVsGsQRIssIYAREALIEIDYGDL
Q6PCD5 S46 GPS6 RFWD3 RNF201 MASSQGGPALLQPVPADVVSsQGVPSILQPAPAEVISsQAT
Q6PCD5 S63 GPS6 RFWD3 RNF201 VVSsQGVPSILQPAPAEVISsQATPPLLQPAPQLSVDLTEV
Q6PGQ7 T501 PSP BORA C13orf34 AESSVIPCESSNIQMDsGYNtQNCGSNIMDTVGAESYCKES
Q7Z6Z7 S2391 PSP HUWE1 KIAA0312 KIAA1578 UREB1 HSPC272 RsGEDEsQEDVLMDEAPsNLsQAsTLQANREDSMNILDPED
Q8IUH4 S8 SIGNOR|PSP ZDHHC13 HIP14L HIP3RP _____________MEGPGLGsQCRNHSHGPHPPGFGRYGIC
Q8IUQ4 S19 GPS6|SIGNOR|PSP SIAH1 HUMSIAH __MSRQTATALPTGTSKCPPsQRVPALTGTTASNNDLASLF
Q8IX01 T7 PSP SUGP2 KIAA0365 SFRS14 ______________MAARRItQETFDAVLQEKAKRYHMDAS
Q8IYD8 S1045 PSP FANCM KIAA1596 CAEHLRSDKCTCLLSHSAVNsQQNLELNSLKCINYPSEKSC
Q8IZL8 S1033 PSP PELP1 HMX3 MNAR GtEEERGADTAPTLAPEALPsQGEVEREGEsPAAGPPPQEL
Q8N163 T454 SIGNOR|PSP CCAR2 DBC1 KIAA1967 PTLEEWEALCQQKAAEAAPPtQEAQGEtEPTEQAPDALEQA
Q8N4S0 S154 PSP CCDC82 HT025 DNDLNKQTGQIIEDDQEKHLsQEDNDLNKQTGQIIEDDLEE
Q8NEM0 S322 PSP MCPH1 LQRNIAGKVVTPDQKQAAGMsQETFEEKYRLsPtLsstKGH
Q8TAQ2 S969 PSP SMARCC2 BAF170 QHFQQMHQQQQQPPPALPPGsQPIPPTGAAGPPAVHGLAVA
Q8WVB6 S74 PSP CHTF18 C16orf41 CTF18 EALARGDAAssPAPAAsVGssQGGARKRQVDADLQPAGsLP
Q8WXE1 S68 GPS6|SIGNOR|ELM|iPTMNet|PSP ATRIP AGS1 PFGAHGDFtADDLEELDtLAsQALsQCPAAARDVSSDHKVH
Q8WXE1 S72 GPS6|SIGNOR|ELM|iPTMNet|PSP ATRIP AGS1 HGDFtADDLEELDtLAsQALsQCPAAARDVSSDHKVHRLLD
Q92831 S264 PSP KAT2B PCAF IVELAKMFLNRINYWHLEAPsQRRLRSPNDDISGYKENYTR
Q96RL1 S205 PSP UIMC1 RAP80 RXRIP110 HTEKTEEEPVsGssGsWDQssQPVFENVNVKSFDRCTGHSA
Q96RU2 S67 SIGNOR|PSP USP28 KIAA1515 SNGDITQAVSLLTDERVKEPsQDtVATEPSEVEGSAANKEV
Q96RU2 S714 SIGNOR|PSP USP28 KIAA1515 EWEEEQSCKIPQMEsstNsssQDYSTsQEPSVASSHGVRCL
Q96SB4 S408 GPS6|PSP SRPK1 VQNLNQESSFLSSQNGDSSTsQETDSCTPITSEVSDTMVCQ
Q96SB4 T326 GPS6|PSP SRPK1 QEEsEsPVERPLKENPPNKMtQEKLEEsstIGQDQtLMERD
Q96SD1 S516 GPS6|PSP DCLRE1C ARTEMIS ASCID SCIDA SNM1C NDEITDEsLENFPSSTVAGGsQsPKLFSDsDGESTHISsQN
Q96SD1 S645 GPS6|PSP DCLRE1C ARTEMIS ASCID SCIDA SNM1C SSETHIPEEKSLLNLSTNADsQsssDFEVPstPEAELPKRE
Q99708 T859 SIGNOR|PSP RBBP8 CTIP RFRYIPPNtPENFWEVGFPStQTCMERGYIKEDLDPCPRPK
Q99728 T714 GPS6 BARD1 LVTAGGGQILSRKPKPDSDVtQTINTVAYHARPDSDQRFCt
Q99728 T734 GPS6 BARD1 tQTINTVAYHARPDSDQRFCtQYIIYEDLCNYHPERVRQGK
Q9BUG6 T422 PSP ZSCAN5A ZNF495 ZSCAN5 HQRTHTGERPYTCDVCQKQFtQKSYLKCHKRSHTGEKPFEC
Q9BW19 S26 SIGNOR|PSP KIFC1 HSET KNSL2 sPLLEVKGNIELKRPLIKAPsQLPLsGsRLKRRPDQMEDGL
Q9BXW9 S717 SIGNOR|PSP FANCD2 FACD INLLPLLFsQDFAKDGGPVTsQESGQKLVSPLCLAPYFRLL
Q9BXW9 T596 PSP FANCD2 FACD IGAVTMAGIMAADRsEsPsLtQERANLSDEQCtQVTSLLQL
Q9BXW9 T608 PSP FANCD2 FACD DRsEsPsLtQERANLSDEQCtQVTSLLQLVHSCSEQSPQAS
Q9BXW9 T691 SIGNOR|PSP FANCD2 FACD VPEGDFPFPVKALYGLEEyDtQDGIAINLLPLLFsQDFAKD
Q9H6E5 S750 PSP TUT1 RBM21 PSHAALAERGPKGHEAAQEWsQGEAGKGASLPSSASWRCAL
Q9NRC8 S134 PSP SIRT7 SIR2L7 ASIPDYRGPNGVWTLLQKGRsVsAADLSEAEPTLTHMSItR
Q9NRC8 S136 PSP SIRT7 SIR2L7 IPDYRGPNGVWTLLQKGRsVsAADLSEAEPTLTHMSItRLH
Q9NVI1 S556 PSP FANCI KIAA1794 AVAGFLLLLKNFKVLGSLSSsQCsQSLSVsQVHVDVHSHYN
Q9NVI1 S559 PSP FANCI KIAA1794 GFLLLLKNFKVLGSLSSsQCsQSLSVsQVHVDVHSHYNSVA
Q9NVI1 S565 PSP FANCI KIAA1794 KNFKVLGSLSSsQCsQSLSVsQVHVDVHSHYNSVANETFCL
Q9NZC9 S652 SIGNOR|PSP SMARCAL1 HARP ELKLLLEEAVMLRRLKSDVLsQLPAKQRKIVVIAPGRINAR
Q9NZN8 S101 PSP CNOT2 CDC36 NOT2 HSPC131 MSTP046 ALGLPMRGMSNNtPQLNRsLsQGtQLPsHVtPTTGVPtMsL
Q9UBU7 S502 SIGNOR|PSP DBF4 ASK DBF4A ZDBF1 YKCNIQASVHVSDFSTDNSGsQPKQKsDtVLFPAKDLKEKD
Q9UBU7 S539 SIGNOR|PSP DBF4 ASK DBF4A ZDBF1 KEKDLHSIFTHDSGLITINSsQEHLTVQAKAPFHtPPEEPN
Q9UBU7 T449 SIGNOR|PSP DBF4 ASK DBF4A ZDBF1 KMSNKCSMLSTAEDDIRQNFtQLPLHKNKQECILDISEHTL
Q9UER7 S424 PSP DAXX BING2 DAP6 HsADtPEAsLDsGEGPsGMAsQGCPsAsRAETDDEDDEESD
Q9UH99 S12 PSP SUN2 FRIGG KIAA0668 RAB5IP UNC84B _________MSRRSQRLtRysQGDDDGssssGGSSVAGsQs
Q9UPV0 S186 GPS6|PSP CEP164 KIAA1052 NPHP15 SVSLGSSVESGRQLGELMLPsQGLKTSAYTKGLLGSIyEDK
Q9UQ84 S714 GPS6 EXO1 EXOI HEX1 QCssKDsDSEESDCNIKLLDsQSDQTSKLRLSHFSKKDTPL
Q9Y248 S182 PSP GINS2 PSF2 CGI-122 DC5 HSPC037 QALNHMYKLRTNLQPLEstQsQDF_________________
Q9Y253 S601 SIGNOR|PSP POLH RAD30 RAD30A XPV VSKLEEsSKATPAEMDLAHNsQSMHASSASKSVLEVtQKAT
Q9Y285 S301 PSP FARSA FARS FARSL FARSLA DPAEALQLPMDYVQRVKRtHsQGGYGSQGYKYNWKLDEARK
Q9Y4P3 T433 GPS6 TBL2 WBSCR13 UNQ563/PRO1125 QGHLKRASNESTRQRLQQQLtQAQETLKSLGALKK______
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 1 0
Cell Cycle, Mitotic R-HSA-69278 2.053691e-12 11.687 0 0
M Phase R-HSA-68886 8.183143e-09 8.087 0 0
Cell Cycle Checkpoints R-HSA-69620 1.534234e-08 7.814 1 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 4.728942e-08 7.325 0 0
DNA Double-Strand Break Repair R-HSA-5693532 9.101002e-08 7.041 1 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.353299e-07 6.869 1 1
Mitotic Prometaphase R-HSA-68877 1.714201e-07 6.766 0 0
Kinesins R-HSA-983189 1.666815e-07 6.778 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.989465e-07 6.701 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.094482e-07 6.679 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 4.034417e-07 6.394 1 1
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 4.329401e-07 6.364 0 0
Mitotic Anaphase R-HSA-68882 7.063683e-07 6.151 0 0
Aggrephagy R-HSA-9646399 8.022194e-07 6.096 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 8.128759e-07 6.090 0 0
Recycling pathway of L1 R-HSA-437239 1.014549e-06 5.994 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.345948e-06 5.871 0 0
Transport of connexons to the plasma membrane R-HSA-190872 2.295075e-06 5.639 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.420525e-06 5.616 1 1
Chromatin organization R-HSA-4839726 3.826636e-06 5.417 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 3.841713e-06 5.415 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 4.251027e-06 5.372 1 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 4.251027e-06 5.372 1 0
Apoptotic cleavage of cellular proteins R-HSA-111465 5.183945e-06 5.285 0 0
Signal Transduction R-HSA-162582 5.300366e-06 5.276 0 0
Separation of Sister Chromatids R-HSA-2467813 5.725989e-06 5.242 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 6.015827e-06 5.221 1 1
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 6.194087e-06 5.208 0 0
Regulation of TP53 Activity R-HSA-5633007 6.502083e-06 5.187 1 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 6.928415e-06 5.159 1 1
Homology Directed Repair R-HSA-5693538 8.305195e-06 5.081 1 0
Transcriptional Regulation by TP53 R-HSA-3700989 8.427549e-06 5.074 1 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.048038e-05 4.980 0 0
PKR-mediated signaling R-HSA-9833482 9.908663e-06 5.004 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.296591e-05 4.887 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.465807e-05 4.834 1 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.585901e-05 4.800 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.596639e-05 4.797 1 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.684398e-05 4.774 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.753363e-05 4.756 1 1
G2/M Checkpoints R-HSA-69481 1.995509e-05 4.700 1 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.013965e-05 4.696 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.166304e-05 4.664 0 0
Chromatin modifying enzymes R-HSA-3247509 2.511531e-05 4.600 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.487222e-05 4.604 1 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.606138e-05 4.584 0 0
Selective autophagy R-HSA-9663891 2.532258e-05 4.596 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.911763e-05 4.536 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 4.877570e-05 4.312 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.977075e-05 4.303 0 0
Post NMDA receptor activation events R-HSA-438064 4.936636e-05 4.307 0 0
Axon guidance R-HSA-422475 5.244639e-05 4.280 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 6.511849e-05 4.186 0 0
Diseases of DNA repair R-HSA-9675135 6.612297e-05 4.180 1 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 6.935550e-05 4.159 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 7.842090e-05 4.106 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 7.842090e-05 4.106 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.034236e-04 3.985 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.034236e-04 3.985 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.034236e-04 3.985 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.034236e-04 3.985 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.218397e-04 3.914 0 0
DNA Repair R-HSA-73894 1.384056e-04 3.859 1 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.398346e-04 3.854 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.688338e-04 3.773 1 1
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.819073e-04 3.740 0 0
Apoptotic execution phase R-HSA-75153 1.829755e-04 3.738 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.868657e-04 3.728 0 0
Nervous system development R-HSA-9675108 1.956893e-04 3.708 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 2.020935e-04 3.694 0 0
Membrane Trafficking R-HSA-199991 2.101433e-04 3.677 0 0
G alpha (12/13) signalling events R-HSA-416482 2.252664e-04 3.647 0 0
Mitotic Prophase R-HSA-68875 2.260797e-04 3.646 0 0
Signaling by EGFR R-HSA-177929 2.498554e-04 3.602 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.532246e-04 3.596 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.602025e-04 3.585 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 2.602025e-04 3.585 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.897953e-04 3.538 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.844542e-04 3.546 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 3.418293e-04 3.466 0 0
Macroautophagy R-HSA-1632852 3.731207e-04 3.428 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 4.432464e-04 3.353 0 0
Signaling by ALK in cancer R-HSA-9700206 4.432464e-04 3.353 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 4.499279e-04 3.347 0 0
snRNP Assembly R-HSA-191859 4.576837e-04 3.339 0 0
Metabolism of non-coding RNA R-HSA-194441 4.576837e-04 3.339 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.787236e-04 3.320 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 4.787236e-04 3.320 0 0
Cellular response to heat stress R-HSA-3371556 5.081213e-04 3.294 1 0
Metabolism of RNA R-HSA-8953854 5.748714e-04 3.240 0 0
Cellular Senescence R-HSA-2559583 6.109179e-04 3.214 0 0
NRAGE signals death through JNK R-HSA-193648 6.132530e-04 3.212 0 0
G2/M Transition R-HSA-69275 6.535158e-04 3.185 0 0
MHC class II antigen presentation R-HSA-2132295 6.569878e-04 3.182 0 0
Estrogen-dependent gene expression R-HSA-9018519 7.069065e-04 3.151 0 0
Autophagy R-HSA-9612973 7.166567e-04 3.145 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 7.739621e-04 3.111 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 7.739621e-04 3.111 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 7.739621e-04 3.111 0 0
Activation of ATR in response to replication stress R-HSA-176187 7.618798e-04 3.118 1 1
Gene expression (Transcription) R-HSA-74160 7.675345e-04 3.115 1 0
Organelle biogenesis and maintenance R-HSA-1852241 7.943287e-04 3.100 0 0
Mitotic G2-G2/M phases R-HSA-453274 7.992864e-04 3.097 0 0
DNA Double Strand Break Response R-HSA-5693606 8.540375e-04 3.069 0 0
mRNA Splicing R-HSA-72172 8.601771e-04 3.065 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 8.691624e-04 3.061 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 8.968179e-04 3.047 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 9.265120e-04 3.033 0 0
Activation of the pre-replicative complex R-HSA-68962 1.012655e-03 2.995 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.012655e-03 2.995 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.008605e-03 2.996 0 0
Gap junction assembly R-HSA-190861 1.240760e-03 2.906 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.293049e-03 2.888 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.299199e-03 2.886 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.304152e-03 2.885 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.304152e-03 2.885 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.351849e-03 2.869 0 0
Meiosis R-HSA-1500620 1.504318e-03 2.823 1 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.450133e-03 2.839 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.451415e-03 2.838 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.596822e-03 2.797 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.651427e-03 2.782 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.736707e-03 2.760 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.736707e-03 2.760 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.743341e-03 2.759 0 0
Death Receptor Signaling R-HSA-73887 1.791167e-03 2.747 0 0
tRNA processing in the nucleus R-HSA-6784531 1.808002e-03 2.743 0 0
L1CAM interactions R-HSA-373760 1.841928e-03 2.735 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.099642e-03 2.678 0 0
Netrin-1 signaling R-HSA-373752 1.995129e-03 2.700 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.099642e-03 2.678 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 2.102304e-03 2.677 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.131770e-03 2.671 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.131770e-03 2.671 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.131770e-03 2.671 0 0
Signaling by PTK6 R-HSA-8848021 2.131770e-03 2.671 0 0
DCC mediated attractive signaling R-HSA-418885 2.146637e-03 2.668 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.146637e-03 2.668 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.246137e-03 2.649 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.277365e-03 2.643 0 0
COPI-mediated anterograde transport R-HSA-6807878 2.577482e-03 2.589 0 0
ER to Golgi Anterograde Transport R-HSA-199977 2.619595e-03 2.582 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.627492e-03 2.580 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.627492e-03 2.580 0 0
Signaling by ERBB2 R-HSA-1227986 2.847374e-03 2.546 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.923370e-03 2.534 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 3.003187e-03 2.522 0 0
Clathrin-mediated endocytosis R-HSA-8856828 3.012220e-03 2.521 0 0
Signaling by MET R-HSA-6806834 3.025516e-03 2.519 0 0
Notch-HLH transcription pathway R-HSA-350054 3.102991e-03 2.508 0 0
Nuclear import of Rev protein R-HSA-180746 3.259866e-03 2.487 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 3.848832e-03 2.415 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.848832e-03 2.415 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.848832e-03 2.415 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.857295e-03 2.414 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 3.900353e-03 2.409 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 3.971796e-03 2.401 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 4.011477e-03 2.397 0 0
Negative regulation of MET activity R-HSA-6807004 4.137985e-03 2.383 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 4.137985e-03 2.383 0 0
Mitotic Spindle Checkpoint R-HSA-69618 4.206652e-03 2.376 0 0
Cilium Assembly R-HSA-5617833 4.335485e-03 2.363 0 0
DNA strand elongation R-HSA-69190 4.405500e-03 2.356 0 0
Gap junction trafficking and regulation R-HSA-157858 4.923823e-03 2.308 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.371058e-03 2.270 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.371058e-03 2.270 0 0
PKMTs methylate histone lysines R-HSA-3214841 5.289017e-03 2.277 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 5.354902e-03 2.271 0 0
Reproduction R-HSA-1474165 5.823796e-03 2.235 1 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 5.302534e-03 2.276 1 1
MITF-M-dependent gene expression R-HSA-9856651 5.871538e-03 2.231 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 5.885574e-03 2.230 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 6.062209e-03 2.217 0 0
Sema4D in semaphorin signaling R-HSA-400685 6.484206e-03 2.188 0 0
Striated Muscle Contraction R-HSA-390522 6.631111e-03 2.178 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 6.689956e-03 2.175 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 6.943864e-03 2.158 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 7.144197e-03 2.146 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 7.253079e-03 2.139 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 7.359648e-03 2.133 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 7.359648e-03 2.133 0 0
Myogenesis R-HSA-525793 8.096883e-03 2.092 0 0
Unwinding of DNA R-HSA-176974 8.801666e-03 2.055 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 9.004394e-03 2.046 0 0
Protein folding R-HSA-391251 9.138477e-03 2.039 0 0
Chaperonin-mediated protein folding R-HSA-390466 8.401946e-03 2.076 0 0
GP1b-IX-V activation signalling R-HSA-430116 8.801666e-03 2.055 0 0
EGFR downregulation R-HSA-182971 8.997456e-03 2.046 0 0
Semaphorin interactions R-HSA-373755 9.236518e-03 2.034 0 0
p75NTR recruits signalling complexes R-HSA-209543 9.659234e-03 2.015 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 9.659234e-03 2.015 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 9.882131e-03 2.005 0 0
IKBKB deficiency causes SCID R-HSA-5602636 9.882131e-03 2.005 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.014227e-02 1.994 0 0
Gap junction trafficking R-HSA-190828 1.045187e-02 1.981 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.090840e-02 1.962 0 0
Centrosome maturation R-HSA-380287 1.154023e-02 1.938 0 0
RET signaling R-HSA-8853659 1.154669e-02 1.938 0 0
RNA Polymerase II Transcription R-HSA-73857 1.179120e-02 1.928 1 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 1.194276e-02 1.923 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 1.194276e-02 1.923 0 0
Nephrin family interactions R-HSA-373753 1.197027e-02 1.922 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.197134e-02 1.922 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 1.262293e-02 1.899 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.262879e-02 1.899 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.331767e-02 1.876 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.336113e-02 1.874 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 1.365321e-02 1.865 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.367580e-02 1.864 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.618022e-02 1.791 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.618022e-02 1.791 0 0
Specification of primordial germ cells R-HSA-9827857 1.633535e-02 1.787 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 1.633535e-02 1.787 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.483696e-02 1.829 0 0
Signaling by Hippo R-HSA-2028269 1.633535e-02 1.787 0 0
Signaling by VEGF R-HSA-194138 1.544333e-02 1.811 0 0
Cellular responses to stress R-HSA-2262752 1.550677e-02 1.809 1 0
Interferon Signaling R-HSA-913531 1.467831e-02 1.833 0 0
Neurexins and neuroligins R-HSA-6794361 1.635309e-02 1.786 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 1.644640e-02 1.784 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.691131e-02 1.772 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.693937e-02 1.771 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.782759e-02 1.749 0 0
Interleukin-37 signaling R-HSA-9008059 1.782759e-02 1.749 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.837581e-02 1.736 0 0
RAF activation R-HSA-5673000 1.852899e-02 1.732 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.866655e-02 1.729 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 1.866655e-02 1.729 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.866655e-02 1.729 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.866655e-02 1.729 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.890131e-02 1.724 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.958737e-02 1.708 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.978664e-02 1.704 0 0
S Phase R-HSA-69242 2.032877e-02 1.692 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.062411e-02 1.686 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 2.107715e-02 1.676 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 2.321605e-02 1.634 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 2.237338e-02 1.650 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.237338e-02 1.650 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.354396e-02 1.628 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.280917e-02 1.642 0 0
p75NTR signals via NF-kB R-HSA-193639 2.237338e-02 1.650 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.171502e-02 1.663 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.351001e-02 1.629 0 0
Signaling by NOTCH3 R-HSA-9012852 2.421210e-02 1.616 0 0
Cellular responses to stimuli R-HSA-8953897 2.164060e-02 1.665 1 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 2.431072e-02 1.614 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 2.522042e-02 1.598 0 0
MAP kinase activation R-HSA-450294 2.650773e-02 1.577 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.650773e-02 1.577 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.745432e-02 1.561 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.745432e-02 1.561 0 0
Meiotic recombination R-HSA-912446 2.816538e-02 1.550 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.883114e-02 1.540 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.462444e-02 1.461 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.462444e-02 1.461 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.462444e-02 1.461 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.462444e-02 1.461 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.462444e-02 1.461 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 3.462444e-02 1.461 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 3.462444e-02 1.461 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 3.020674e-02 1.520 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 3.020674e-02 1.520 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.197437e-02 1.495 0 0
IRAK1 recruits IKK complex R-HSA-937039 3.077606e-02 1.512 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 3.077606e-02 1.512 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.148549e-02 1.502 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.326865e-02 1.478 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 3.326865e-02 1.478 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.948391e-02 1.530 0 0
Nuclear Receptor transcription pathway R-HSA-383280 2.916197e-02 1.535 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 3.077606e-02 1.512 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.957232e-02 1.529 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.270385e-02 1.485 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.957232e-02 1.529 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 3.077606e-02 1.512 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.948391e-02 1.530 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.413894e-02 1.467 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.948391e-02 1.530 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 3.020674e-02 1.520 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.188818e-02 1.496 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 3.069347e-02 1.513 0 0
HCMV Early Events R-HSA-9609690 3.514215e-02 1.454 0 0
ESR-mediated signaling R-HSA-8939211 3.515512e-02 1.454 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.545728e-02 1.450 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.545728e-02 1.450 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.593209e-02 1.445 0 0
Apoptosis R-HSA-109581 3.640815e-02 1.439 0 0
MET interacts with TNS proteins R-HSA-8875513 3.707304e-02 1.431 0 0
Interleukin-17 signaling R-HSA-448424 3.927594e-02 1.406 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 3.937050e-02 1.405 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 3.937050e-02 1.405 0 0
HDMs demethylate histones R-HSA-3214842 3.952238e-02 1.403 0 0
Interleukin-7 signaling R-HSA-1266695 3.952238e-02 1.403 0 0
NOD1/2 Signaling Pathway R-HSA-168638 3.978867e-02 1.400 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.996929e-02 1.398 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.064581e-02 1.391 0 0
Signaling by NOTCH1 R-HSA-1980143 4.123444e-02 1.385 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 4.255190e-02 1.371 0 0
Regulation of CDH11 function R-HSA-9762292 4.255190e-02 1.371 0 0
Generic Transcription Pathway R-HSA-212436 4.339975e-02 1.363 1 0
RMTs methylate histone arginines R-HSA-3214858 4.340367e-02 1.362 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 4.572229e-02 1.340 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 4.572229e-02 1.340 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 4.572229e-02 1.340 0 0
Downstream signal transduction R-HSA-186763 4.644846e-02 1.333 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.652815e-02 1.332 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 4.687676e-02 1.329 0 0
Mitochondrial biogenesis R-HSA-1592230 4.695930e-02 1.328 0 0
Fanconi Anemia Pathway R-HSA-6783310 4.899966e-02 1.310 1 1
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 5.031796e-02 1.298 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.078240e-02 1.294 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 5.774278e-02 1.239 0 0
SOS-mediated signalling R-HSA-112412 5.917645e-02 1.228 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 5.917645e-02 1.228 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 5.500344e-02 1.260 0 0
Erythropoietin activates RAS R-HSA-9027284 6.075394e-02 1.216 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.075394e-02 1.216 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 6.075394e-02 1.216 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 6.075394e-02 1.216 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 5.280343e-02 1.277 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 5.280343e-02 1.277 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 5.280343e-02 1.277 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 5.280343e-02 1.277 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 5.280343e-02 1.277 0 0
Diseases of mitotic cell cycle R-HSA-9675126 5.360011e-02 1.271 0 0
Signaling by RAF1 mutants R-HSA-9656223 5.738083e-02 1.241 0 0
Signaling by RAS mutants R-HSA-6802949 5.507370e-02 1.259 0 0
Signaling downstream of RAS mutants R-HSA-9649948 5.507370e-02 1.259 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 5.507370e-02 1.259 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 5.507370e-02 1.259 0 0
Integrin signaling R-HSA-354192 6.144365e-02 1.212 0 0
HATs acetylate histones R-HSA-3214847 5.526724e-02 1.258 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.864729e-02 1.232 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 6.452900e-02 1.190 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 6.059539e-02 1.218 0 0
Signaling by FGFR1 in disease R-HSA-5655302 5.738083e-02 1.241 0 0
Deubiquitination R-HSA-5688426 6.450222e-02 1.190 0 0
Vesicle-mediated transport R-HSA-5653656 6.321663e-02 1.199 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 5.420317e-02 1.266 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 5.311643e-02 1.275 0 0
Cell-Cell communication R-HSA-1500931 6.131703e-02 1.212 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 5.280343e-02 1.277 0 0
STING mediated induction of host immune responses R-HSA-1834941 6.316984e-02 1.199 0 0
Sensory processing of sound R-HSA-9659379 5.445128e-02 1.264 0 0
Meiotic synapsis R-HSA-1221632 6.524453e-02 1.185 1 1
Regulation of CDH1 Gene Transcription R-HSA-9764560 6.683637e-02 1.175 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 6.734878e-02 1.172 0 0
Signaling by NTRKs R-HSA-166520 6.757378e-02 1.170 0 0
Intraflagellar transport R-HSA-5620924 6.870667e-02 1.163 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 6.934252e-02 1.159 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 7.086416e-02 1.150 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 7.095406e-02 1.149 0 0
Breakdown of the nuclear lamina R-HSA-352238 7.095406e-02 1.149 0 0
Cytokine Signaling in Immune system R-HSA-1280215 7.116602e-02 1.148 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 7.162330e-02 1.145 0 0
Signaling by Erythropoietin R-HSA-9006335 7.230112e-02 1.141 0 0
Termination of translesion DNA synthesis R-HSA-5656169 7.230112e-02 1.141 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 7.359238e-02 1.133 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 7.359238e-02 1.133 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 7.359238e-02 1.133 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 7.400983e-02 1.131 0 0
Regulation of PTEN gene transcription R-HSA-8943724 7.512776e-02 1.124 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 7.512776e-02 1.124 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 7.512776e-02 1.124 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 7.512776e-02 1.124 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 7.512776e-02 1.124 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 7.512776e-02 1.124 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 7.628545e-02 1.118 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 7.628545e-02 1.118 0 0
SARS-CoV-2-host interactions R-HSA-9705683 7.765465e-02 1.110 0 0
Type I hemidesmosome assembly R-HSA-446107 7.769158e-02 1.110 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 7.769158e-02 1.110 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 7.769158e-02 1.110 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 7.940644e-02 1.100 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 7.940644e-02 1.100 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 7.940644e-02 1.100 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 8.272204e-02 1.082 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 8.272204e-02 1.082 0 0
Long-term potentiation R-HSA-9620244 8.535634e-02 1.069 0 0
MET activates RAS signaling R-HSA-8851805 8.554384e-02 1.068 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 8.554384e-02 1.068 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 8.554384e-02 1.068 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 8.554384e-02 1.068 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 8.554384e-02 1.068 0 0
Activation of HOX genes during differentiation R-HSA-5619507 8.576968e-02 1.067 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 8.576968e-02 1.067 0 0
MyD88-independent TLR4 cascade R-HSA-166166 8.612099e-02 1.065 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 8.612099e-02 1.065 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.150263e-01 0.939 0 0
Regulation of TP53 Expression R-HSA-6804754 1.150263e-01 0.939 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.150263e-01 0.939 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.150263e-01 0.939 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.150263e-01 0.939 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.150263e-01 0.939 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.150263e-01 0.939 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.150263e-01 0.939 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.150263e-01 0.939 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.150263e-01 0.939 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.150263e-01 0.939 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.150263e-01 0.939 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 1.115003e-01 0.953 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 1.115003e-01 0.953 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.115003e-01 0.953 0 0
ALK mutants bind TKIs R-HSA-9700645 9.873988e-02 1.006 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.785834e-02 1.056 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.035229e-01 0.985 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.035229e-01 0.985 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 1.035229e-01 0.985 0 0
Lagging Strand Synthesis R-HSA-69186 8.736183e-02 1.059 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 9.766336e-02 1.010 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.109182e-01 0.955 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.109182e-01 0.955 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 9.879600e-02 1.005 0 0
Signaling by ERBB4 R-HSA-1236394 9.383629e-02 1.028 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.015302e-01 0.993 0 0
Extension of Telomeres R-HSA-180786 1.141123e-01 0.943 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 8.736183e-02 1.059 0 0
Synthesis of DNA R-HSA-69239 1.045542e-01 0.981 0 0
Interleukin-6 signaling R-HSA-1059683 1.035467e-01 0.985 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 9.873988e-02 1.006 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 1.049285e-01 0.979 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 9.591682e-02 1.018 0 0
EPH-Ephrin signaling R-HSA-2682334 1.113934e-01 0.953 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 1.113539e-01 0.953 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 1.035229e-01 0.985 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 1.035229e-01 0.985 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.113868e-01 0.953 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 8.633979e-02 1.064 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 9.766336e-02 1.010 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 9.457341e-02 1.024 0 0
Interleukin-12 family signaling R-HSA-447115 1.110459e-01 0.954 0 0
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization R-HSA-180897 1.150263e-01 0.939 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.115419e-01 0.953 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 9.766336e-02 1.010 0 0
Programmed Cell Death R-HSA-5357801 1.129027e-01 0.947 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 1.109182e-01 0.955 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 9.692618e-02 1.014 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 9.873988e-02 1.006 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 8.936789e-02 1.049 0 0
Interleukin-12 signaling R-HSA-9020591 1.096051e-01 0.960 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 1.115003e-01 0.953 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 1.161048e-01 0.935 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 1.161048e-01 0.935 0 0
Signaling by KIT in disease R-HSA-9669938 1.161048e-01 0.935 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.184235e-01 0.927 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 1.184235e-01 0.927 0 0
Ephrin signaling R-HSA-3928664 1.205380e-01 0.919 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.205380e-01 0.919 0 0
Mismatch Repair R-HSA-5358508 1.205380e-01 0.919 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.205380e-01 0.919 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.221299e-01 0.913 0 0
Signaling by Leptin R-HSA-2586552 1.221299e-01 0.913 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.221299e-01 0.913 0 0
Removal of the Flap Intermediate R-HSA-69166 1.232592e-01 0.909 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.232592e-01 0.909 0 0
Signaling by FGFR4 in disease R-HSA-5655291 1.232592e-01 0.909 0 0
MAPK family signaling cascades R-HSA-5683057 1.238710e-01 0.907 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 1.248631e-01 0.904 0 0
Signaling by SCF-KIT R-HSA-1433557 1.275367e-01 0.894 0 0
DNA Damage Bypass R-HSA-73893 1.305103e-01 0.884 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.316123e-01 0.881 0 0
Syndecan interactions R-HSA-3000170 1.321120e-01 0.879 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.321120e-01 0.879 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.347702e-01 0.870 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.347702e-01 0.870 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.347702e-01 0.870 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.347702e-01 0.870 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.347702e-01 0.870 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.347702e-01 0.870 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.347702e-01 0.870 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.347702e-01 0.870 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.347702e-01 0.870 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.347702e-01 0.870 0 0
Glycolysis R-HSA-70171 1.348859e-01 0.870 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.363464e-01 0.865 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.388382e-01 0.857 0 0
Rap1 signalling R-HSA-392517 1.388382e-01 0.857 0 0
G1 Phase R-HSA-69236 1.397687e-01 0.855 0 0
Cyclin D associated events in G1 R-HSA-69231 1.397687e-01 0.855 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.397687e-01 0.855 0 0
Chylomicron clearance R-HSA-8964026 1.434880e-01 0.843 0 0
Erythropoietin activates STAT5 R-HSA-9027283 1.434880e-01 0.843 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 1.434880e-01 0.843 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 1.434880e-01 0.843 0 0
MET activates STAT3 R-HSA-8875791 1.640961e-01 0.785 0 0
MET activates PTPN11 R-HSA-8865999 1.640961e-01 0.785 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 1.640961e-01 0.785 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 1.640961e-01 0.785 0 0
Invadopodia formation R-HSA-8941237 1.640961e-01 0.785 0 0
Regulation of gap junction activity R-HSA-191650 2.160173e-01 0.666 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 2.160173e-01 0.666 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 2.160173e-01 0.666 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.160173e-01 0.666 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.160173e-01 0.666 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.160173e-01 0.666 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 2.160173e-01 0.666 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 2.160173e-01 0.666 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.780662e-01 0.749 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.780662e-01 0.749 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 1.780662e-01 0.749 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 1.780662e-01 0.749 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 1.780662e-01 0.749 0 0
Regulation of PTEN localization R-HSA-8948747 1.780662e-01 0.749 0 0
Netrin mediated repulsion signals R-HSA-418886 1.780662e-01 0.749 0 0
PTK6 Expression R-HSA-8849473 1.780662e-01 0.749 0 0
Activation of RAS in B cells R-HSA-1169092 2.146207e-01 0.668 0 0
MET receptor recycling R-HSA-8875656 2.146207e-01 0.668 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.749654e-01 0.757 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 1.749654e-01 0.757 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.749654e-01 0.757 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.445635e-01 0.840 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 1.445635e-01 0.840 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 1.445635e-01 0.840 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.445635e-01 0.840 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.445635e-01 0.840 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.445635e-01 0.840 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 1.673200e-01 0.776 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.673200e-01 0.776 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 2.038627e-01 0.691 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.038627e-01 0.691 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.038627e-01 0.691 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.038627e-01 0.691 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.038627e-01 0.691 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.038627e-01 0.691 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.038627e-01 0.691 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 1.913731e-01 0.718 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 1.913731e-01 0.718 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 1.491484e-01 0.826 0 0
Deadenylation of mRNA R-HSA-429947 1.491484e-01 0.826 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.789591e-01 0.747 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.789591e-01 0.747 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.561152e-01 0.807 0 0
Dual Incision in GG-NER R-HSA-5696400 1.458561e-01 0.836 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 1.860663e-01 0.730 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 1.498446e-01 0.824 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.058060e-01 0.687 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.058060e-01 0.687 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 1.903840e-01 0.720 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.765247e-01 0.753 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 1.765247e-01 0.753 0 0
mRNA 3'-end processing R-HSA-72187 1.671835e-01 0.777 0 0
HDACs deacetylate histones R-HSA-3214815 2.083802e-01 0.681 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.069118e-01 0.684 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.519207e-01 0.818 0 0
RNA Polymerase III Transcription R-HSA-74158 1.765247e-01 0.753 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.639913e-01 0.785 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 1.561152e-01 0.807 0 0
Telomere Maintenance R-HSA-157579 1.623055e-01 0.790 0 0
Adipogenesis R-HSA-9843745 1.772097e-01 0.752 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.667974e-01 0.778 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.988736e-01 0.701 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 1.530536e-01 0.815 0 0
MTOR signalling R-HSA-165159 1.941149e-01 0.712 0 0
RNA Polymerase I Transcription R-HSA-73864 1.893119e-01 0.723 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.525992e-01 0.816 0 0
Oncogene Induced Senescence R-HSA-2559585 1.608385e-01 0.794 0 0
Nucleotide Excision Repair R-HSA-5696398 1.893815e-01 0.723 0 0
Metalloprotease DUBs R-HSA-5689901 1.860663e-01 0.730 0 0
MAP2K and MAPK activation R-HSA-5674135 1.787587e-01 0.748 0 0
DAP12 signaling R-HSA-2424491 1.561152e-01 0.807 0 0
Nuclear RNA decay R-HSA-9930044 2.086084e-01 0.681 0 0
FOXO-mediated transcription R-HSA-9614085 1.816892e-01 0.741 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.660086e-01 0.780 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.871414e-01 0.728 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 2.160173e-01 0.666 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.498446e-01 0.824 0 0
Hedgehog 'off' state R-HSA-5610787 1.918072e-01 0.717 0 0
Signaling by PDGF R-HSA-186797 1.449430e-01 0.839 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.860663e-01 0.730 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 2.077535e-01 0.682 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.803473e-01 0.744 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.875589e-01 0.727 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.603851e-01 0.795 0 0
Circadian clock R-HSA-9909396 1.857850e-01 0.731 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.105904e-01 0.677 0 0
DNA Replication R-HSA-69306 1.677360e-01 0.775 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 1.913731e-01 0.718 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.086084e-01 0.681 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 1.493813e-01 0.826 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.105038e-01 0.677 0 0
Signaling by FGFR in disease R-HSA-1226099 2.158566e-01 0.666 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 2.146207e-01 0.668 0 0
Signaling by LTK R-HSA-9842663 2.038627e-01 0.691 0 0
HIV Life Cycle R-HSA-162587 1.995321e-01 0.700 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.058060e-01 0.687 0 0
RUNX2 regulates bone development R-HSA-8941326 1.765247e-01 0.753 0 0
Cell junction organization R-HSA-446728 2.025733e-01 0.693 0 0
Signaling by Interleukins R-HSA-449147 1.709059e-01 0.767 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 2.005825e-01 0.698 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.640961e-01 0.785 0 0
Dopamine receptors R-HSA-390651 2.160173e-01 0.666 0 0
NF-kB is activated and signals survival R-HSA-209560 1.749654e-01 0.757 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.445635e-01 0.840 0 0
Disorders of Developmental Biology R-HSA-9675151 1.913731e-01 0.718 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 1.677679e-01 0.775 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.934176e-01 0.714 0 0
Heme signaling R-HSA-9707616 1.449430e-01 0.839 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.909077e-01 0.719 0 0
PECAM1 interactions R-HSA-210990 1.476268e-01 0.831 0 0
NGF-stimulated transcription R-HSA-9031628 1.944694e-01 0.711 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 1.749654e-01 0.757 0 0
Mitochondrial calcium ion transport R-HSA-8949215 2.005825e-01 0.698 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 2.058060e-01 0.687 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 1.476268e-01 0.831 0 0
Host Interactions of HIV factors R-HSA-162909 2.100547e-01 0.678 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.165555e-01 0.664 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 2.165555e-01 0.664 0 0
Platelet activation, signaling and aggregation R-HSA-76002 2.191380e-01 0.659 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.208078e-01 0.656 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 2.230122e-01 0.652 0 0
TNF signaling R-HSA-75893 2.230122e-01 0.652 0 0
FGFR2 alternative splicing R-HSA-6803529 2.231015e-01 0.651 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 2.231015e-01 0.651 0 0
mTORC1-mediated signalling R-HSA-166208 2.231015e-01 0.651 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 2.234723e-01 0.651 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 2.234723e-01 0.651 0 0
HIV elongation arrest and recovery R-HSA-167287 2.262940e-01 0.645 0 0
Pausing and recovery of HIV elongation R-HSA-167290 2.262940e-01 0.645 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 2.262940e-01 0.645 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.264500e-01 0.645 0 0
Signaling by ALK R-HSA-201556 2.273884e-01 0.643 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 2.297994e-01 0.639 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 2.297994e-01 0.639 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 2.297994e-01 0.639 0 0
G1/S Transition R-HSA-69206 2.297994e-01 0.639 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 2.340275e-01 0.631 0 0
Processing of SMDT1 R-HSA-8949664 2.340275e-01 0.631 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 2.340275e-01 0.631 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 2.340275e-01 0.631 0 0
HCMV Infection R-HSA-9609646 2.341246e-01 0.631 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.513841e-01 0.600 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.513841e-01 0.600 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.513841e-01 0.600 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.513841e-01 0.600 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.513841e-01 0.600 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.513841e-01 0.600 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 3.522869e-01 0.453 0 0
Mitochondrial transcription initiation R-HSA-163282 3.522869e-01 0.453 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.522869e-01 0.453 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.522869e-01 0.453 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.522869e-01 0.453 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.522869e-01 0.453 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.522869e-01 0.453 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.522869e-01 0.453 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 3.522869e-01 0.453 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 3.522869e-01 0.453 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.522869e-01 0.453 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.522869e-01 0.453 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.691309e-01 0.570 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.691309e-01 0.570 0 0
IRS activation R-HSA-74713 2.691309e-01 0.570 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 2.691309e-01 0.570 0 0
Calcineurin activates NFAT R-HSA-2025928 2.525663e-01 0.598 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 3.221731e-01 0.492 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 3.221731e-01 0.492 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 3.221731e-01 0.492 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.221731e-01 0.492 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 4.395944e-01 0.357 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.395944e-01 0.357 0 0
Signaling by RAS GAP mutants R-HSA-9753510 4.395944e-01 0.357 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 4.395944e-01 0.357 0 0
Essential pentosuria R-HSA-5662853 4.395944e-01 0.357 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 2.913621e-01 0.536 0 0
2-LTR circle formation R-HSA-164843 2.913621e-01 0.536 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 3.741988e-01 0.427 0 0
Signaling by LTK in cancer R-HSA-9842640 3.741988e-01 0.427 0 0
Autointegration results in viral DNA circles R-HSA-177539 3.741988e-01 0.427 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.741988e-01 0.427 0 0
Signaling by APC mutants R-HSA-4839744 3.305204e-01 0.481 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 3.305204e-01 0.481 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 3.305204e-01 0.481 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 3.305204e-01 0.481 0 0
p38MAPK events R-HSA-171007 2.970064e-01 0.527 0 0
Translesion Synthesis by POLH R-HSA-110320 2.696068e-01 0.569 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 3.292690e-01 0.482 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 3.292690e-01 0.482 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 3.696116e-01 0.432 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 3.696116e-01 0.432 0 0
Activation of RAC1 R-HSA-428540 3.696116e-01 0.432 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 3.696116e-01 0.432 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 4.245186e-01 0.372 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 4.245186e-01 0.372 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 4.245186e-01 0.372 0 0
IFNG signaling activates MAPKs R-HSA-9732724 4.245186e-01 0.372 0 0
TRIF-mediated programmed cell death R-HSA-2562578 4.245186e-01 0.372 0 0
VLDL clearance R-HSA-8964046 4.245186e-01 0.372 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 4.245186e-01 0.372 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 2.691710e-01 0.570 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.454532e-01 0.610 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 3.617053e-01 0.442 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 4.082651e-01 0.389 0 0
Leading Strand Synthesis R-HSA-69109 4.082651e-01 0.389 0 0
Polymerase switching R-HSA-69091 4.082651e-01 0.389 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 3.532592e-01 0.452 0 0
Dual incision in TC-NER R-HSA-6782135 2.534608e-01 0.596 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 3.940838e-01 0.404 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 4.726475e-01 0.325 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 4.726475e-01 0.325 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 4.726475e-01 0.325 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 4.726475e-01 0.325 0 0
MET promotes cell motility R-HSA-8875878 3.291914e-01 0.483 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.461675e-01 0.351 0 0
Stabilization of p53 R-HSA-69541 3.505122e-01 0.455 0 0
GAB1 signalosome R-HSA-180292 4.261950e-01 0.370 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 3.957096e-01 0.403 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 3.832415e-01 0.417 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.719938e-01 0.429 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 3.274514e-01 0.485 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.612202e-01 0.442 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.711333e-01 0.430 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 3.818561e-01 0.418 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 4.210859e-01 0.376 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.210859e-01 0.376 0 0
Thromboxane signalling through TP receptor R-HSA-428930 4.378579e-01 0.359 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 4.578525e-01 0.339 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 3.901751e-01 0.409 0 0
Translation initiation complex formation R-HSA-72649 4.092715e-01 0.388 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.474474e-01 0.349 0 0
Regulation of RAS by GAPs R-HSA-5658442 4.626279e-01 0.335 0 0
PTEN Regulation R-HSA-6807070 4.100695e-01 0.387 0 0
Signaling by FGFR3 R-HSA-5654741 3.617045e-01 0.442 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.197366e-01 0.495 0 0
Signaling by FGFR4 R-HSA-5654743 3.218367e-01 0.492 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 2.783982e-01 0.555 0 0
Signaling by FGFR2 R-HSA-5654738 2.981185e-01 0.526 0 0
Pexophagy R-HSA-9664873 2.913621e-01 0.536 0 0
Chromosome Maintenance R-HSA-73886 3.175589e-01 0.498 0 0
Signaling by FGFR1 R-HSA-5654736 4.474474e-01 0.349 0 0
Signal amplification R-HSA-392518 3.832415e-01 0.417 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 3.449252e-01 0.462 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 4.082651e-01 0.389 0 0
HSF1-dependent transactivation R-HSA-3371571 3.521928e-01 0.453 0 0
Integration of provirus R-HSA-162592 3.696116e-01 0.432 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 3.449252e-01 0.462 0 0
Formation of definitive endoderm R-HSA-9823730 2.971208e-01 0.527 0 0
Josephin domain DUBs R-HSA-5689877 2.913621e-01 0.536 0 0
Interleukin-23 signaling R-HSA-9020933 4.726475e-01 0.325 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.981185e-01 0.526 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 3.548838e-01 0.450 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 4.091279e-01 0.388 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 2.525663e-01 0.598 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 2.525663e-01 0.598 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 3.221731e-01 0.492 0 0
Formation of lateral plate mesoderm R-HSA-9758920 3.221731e-01 0.492 0 0
PI3K/AKT activation R-HSA-198203 2.913621e-01 0.536 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 3.741988e-01 0.427 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 3.741988e-01 0.427 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 3.815561e-01 0.418 0 0
Attenuation phase R-HSA-3371568 3.719938e-01 0.429 0 0
Assembly of the pre-replicative complex R-HSA-68867 4.226446e-01 0.374 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.975616e-01 0.526 0 0
Platelet sensitization by LDL R-HSA-432142 2.426926e-01 0.615 0 0
Interleukin-35 Signalling R-HSA-8984722 4.082651e-01 0.389 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 4.466290e-01 0.350 0 0
Interleukin-6 family signaling R-HSA-6783589 4.378579e-01 0.359 0 0
Triglyceride catabolism R-HSA-163560 4.297543e-01 0.367 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 2.549605e-01 0.594 0 0
Growth hormone receptor signaling R-HSA-982772 2.463983e-01 0.608 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 2.948385e-01 0.530 0 0
Signaling by ROBO receptors R-HSA-376176 2.689044e-01 0.570 0 0
Signaling by NOTCH R-HSA-157118 2.575897e-01 0.589 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 2.549605e-01 0.594 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 4.223151e-01 0.374 0 0
Signal attenuation R-HSA-74749 2.913621e-01 0.536 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 3.596306e-01 0.444 0 0
Signalling to RAS R-HSA-167044 3.250609e-01 0.488 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.925612e-01 0.406 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.034989e-01 0.518 0 0
Toll-like Receptor Cascades R-HSA-168898 4.807704e-01 0.318 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 2.691309e-01 0.570 0 0
Transcription from mitochondrial promoters R-HSA-75944 4.395944e-01 0.357 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 2.913621e-01 0.536 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.741988e-01 0.427 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 4.578525e-01 0.339 0 0
Cargo concentration in the ER R-HSA-5694530 4.463155e-01 0.350 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 4.655971e-01 0.332 0 0
Interleukin-1 signaling R-HSA-9020702 4.551977e-01 0.342 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.860227e-01 0.413 0 0
LDL clearance R-HSA-8964038 3.815561e-01 0.418 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.874422e-01 0.541 0 0
Signaling by NOTCH4 R-HSA-9013694 4.091279e-01 0.388 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.617053e-01 0.442 0 0
Activation of BH3-only proteins R-HSA-114452 4.210859e-01 0.376 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.416918e-01 0.466 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 2.474452e-01 0.607 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 4.517294e-01 0.345 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.879767e-01 0.411 0 0
Signaling by FGFR3 in disease R-HSA-5655332 3.449252e-01 0.462 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 3.935672e-01 0.405 0 0
Rab regulation of trafficking R-HSA-9007101 2.709593e-01 0.567 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 4.555050e-01 0.342 0 0
Signaling by Hedgehog R-HSA-5358351 3.207748e-01 0.494 0 0
Developmental Biology R-HSA-1266738 3.585314e-01 0.445 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.422563e-01 0.616 0 0
Co-stimulation by CD28 R-HSA-389356 2.964557e-01 0.528 0 0
Signaling by WNT R-HSA-195721 3.490494e-01 0.457 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 2.691309e-01 0.570 0 0
TBC/RABGAPs R-HSA-8854214 3.218367e-01 0.492 0 0
HSF1 activation R-HSA-3371511 4.297543e-01 0.367 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.669014e-01 0.574 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.650170e-01 0.577 0 0
Neurodegenerative Diseases R-HSA-8863678 2.703516e-01 0.568 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.703516e-01 0.568 0 0
PERK regulates gene expression R-HSA-381042 2.669014e-01 0.574 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.378579e-01 0.359 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 4.528700e-01 0.344 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 3.619081e-01 0.441 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 3.619081e-01 0.441 0 0
Adherens junctions interactions R-HSA-418990 3.535406e-01 0.452 0 0
Cell-cell junction organization R-HSA-421270 4.722542e-01 0.326 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 4.602202e-01 0.337 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.513841e-01 0.600 0 0
SDK interactions R-HSA-373756 2.513841e-01 0.600 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.522869e-01 0.453 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.522869e-01 0.453 0 0
mRNA Editing: A to I Conversion R-HSA-75064 4.395944e-01 0.357 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 4.395944e-01 0.357 0 0
C6 deamination of adenosine R-HSA-75102 4.395944e-01 0.357 0 0
Signalling to ERK5 R-HSA-198765 4.395944e-01 0.357 0 0
Influenza Virus Induced Apoptosis R-HSA-168277 4.395944e-01 0.357 0 0
Interleukin-27 signaling R-HSA-9020956 2.913621e-01 0.536 0 0
Regulation of KIT signaling R-HSA-1433559 2.651695e-01 0.576 0 0
CREB phosphorylation R-HSA-199920 3.741988e-01 0.427 0 0
Bicarbonate transporters R-HSA-425381 3.305204e-01 0.481 0 0
Signaling by AMER1 mutants R-HSA-4839748 3.696116e-01 0.432 0 0
Signaling by AXIN mutants R-HSA-4839735 3.696116e-01 0.432 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 4.245186e-01 0.372 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 4.245186e-01 0.372 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 3.250609e-01 0.488 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 3.197366e-01 0.495 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 4.726475e-01 0.325 0 0
Insulin receptor recycling R-HSA-77387 3.702870e-01 0.431 0 0
Orc1 removal from chromatin R-HSA-68949 3.711333e-01 0.430 0 0
Degradation of CDH1 R-HSA-9766229 4.425154e-01 0.354 0 0
Signaling by FGFR2 in disease R-HSA-5655253 4.626279e-01 0.335 0 0
Cardiogenesis R-HSA-9733709 3.368873e-01 0.473 0 0
GPVI-mediated activation cascade R-HSA-114604 2.873146e-01 0.542 0 0
Calmodulin induced events R-HSA-111933 4.297543e-01 0.367 0 0
Neuronal System R-HSA-112316 4.109924e-01 0.386 0 0
HIV Infection R-HSA-162906 4.394308e-01 0.357 0 0
Transmission across Chemical Synapses R-HSA-112315 2.850153e-01 0.545 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.256007e-01 0.487 0 0
Signalling to ERKs R-HSA-187687 4.065192e-01 0.391 0 0
CaM pathway R-HSA-111997 4.297543e-01 0.367 0 0
Interleukin-1 family signaling R-HSA-446652 2.716819e-01 0.566 0 0
Hemostasis R-HSA-109582 2.512304e-01 0.600 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 3.305204e-01 0.481 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.939490e-01 0.532 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.823707e-01 0.549 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.504938e-01 0.346 0 0
DAP12 interactions R-HSA-2172127 4.794804e-01 0.319 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 3.218367e-01 0.492 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 3.139834e-01 0.503 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.221731e-01 0.492 0 0
Pervasive developmental disorders R-HSA-9005895 4.082651e-01 0.389 0 0
Disorders of Nervous System Development R-HSA-9697154 4.082651e-01 0.389 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 4.082651e-01 0.389 0 0
Uptake and function of anthrax toxins R-HSA-5210891 3.940838e-01 0.404 0 0
Other interleukin signaling R-HSA-449836 4.578525e-01 0.339 0 0
Base Excision Repair R-HSA-73884 3.634997e-01 0.439 0 0
Inhibition of membrane repair R-HSA-9635644 3.522869e-01 0.453 0 0
DSCAM interactions R-HSA-376172 4.395944e-01 0.357 0 0
Diseases of cellular response to stress R-HSA-9675132 4.395944e-01 0.357 0 0
Diseases of Cellular Senescence R-HSA-9630747 4.395944e-01 0.357 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 3.741988e-01 0.427 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 3.250609e-01 0.488 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 4.378579e-01 0.359 0 0
Potential therapeutics for SARS R-HSA-9679191 4.719987e-01 0.326 0 0
FLT3 signaling in disease R-HSA-9682385 4.297543e-01 0.367 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.525663e-01 0.598 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 3.741988e-01 0.427 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.741988e-01 0.427 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 4.726475e-01 0.325 0 0
Tie2 Signaling R-HSA-210993 4.261950e-01 0.370 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 2.525663e-01 0.598 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 2.970064e-01 0.527 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 4.245186e-01 0.372 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 4.378579e-01 0.359 0 0
Inositol phosphate metabolism R-HSA-1483249 3.442699e-01 0.463 0 0
Glucose metabolism R-HSA-70326 3.492577e-01 0.457 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 4.395944e-01 0.357 0 0
Nef and signal transduction R-HSA-164944 3.741988e-01 0.427 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 4.245186e-01 0.372 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 3.832415e-01 0.417 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.970064e-01 0.527 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.292690e-01 0.482 0 0
Gene Silencing by RNA R-HSA-211000 2.817459e-01 0.550 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 4.830606e-01 0.316 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 4.830606e-01 0.316 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 4.830606e-01 0.316 0 0
NRIF signals cell death from the nucleus R-HSA-205043 4.830606e-01 0.316 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.830606e-01 0.316 0 0
Signal regulatory protein family interactions R-HSA-391160 4.830606e-01 0.316 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 4.830606e-01 0.316 0 0
Co-inhibition by CTLA4 R-HSA-389513 4.888931e-01 0.311 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.888931e-01 0.311 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 4.888931e-01 0.311 0 0
Signal transduction by L1 R-HSA-445144 4.888931e-01 0.311 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 4.959687e-01 0.305 0 0
Response of endothelial cells to shear stress R-HSA-9860931 4.981751e-01 0.303 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 4.984579e-01 0.302 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 4.984579e-01 0.302 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 4.984579e-01 0.302 0 0
Influenza Infection R-HSA-168255 4.998771e-01 0.301 0 0
DAG and IP3 signaling R-HSA-1489509 5.005648e-01 0.301 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 5.023998e-01 0.299 0 0
Post-translational protein phosphorylation R-HSA-8957275 5.113883e-01 0.291 0 0
Signaling by FGFR R-HSA-190236 5.113883e-01 0.291 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 5.150343e-01 0.288 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 5.151378e-01 0.288 0 0
PLC-gamma1 signalling R-HSA-167021 5.151378e-01 0.288 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 5.151378e-01 0.288 0 0
Activation of BMF and translocation to mitochondria R-HSA-139910 5.151378e-01 0.288 0 0
Signalling to STAT3 R-HSA-198745 5.151378e-01 0.288 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 5.151378e-01 0.288 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 5.151378e-01 0.288 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 5.151378e-01 0.288 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 5.151378e-01 0.288 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 5.151378e-01 0.288 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 5.182620e-01 0.285 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 5.182620e-01 0.285 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 5.182620e-01 0.285 0 0
Lipophagy R-HSA-9613354 5.182620e-01 0.285 0 0
Interleukin-21 signaling R-HSA-9020958 5.182620e-01 0.285 0 0
WNT mediated activation of DVL R-HSA-201688 5.182620e-01 0.285 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 5.182620e-01 0.285 0 0
Regulated proteolysis of p75NTR R-HSA-193692 5.182620e-01 0.285 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 5.182620e-01 0.285 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 5.182620e-01 0.285 0 0
Cellular response to mitochondrial stress R-HSA-9840373 5.182620e-01 0.285 0 0
MAPK1 (ERK2) activation R-HSA-112411 5.182620e-01 0.285 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 5.182620e-01 0.285 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 5.182620e-01 0.285 0 0
Spry regulation of FGF signaling R-HSA-1295596 5.187367e-01 0.285 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.187367e-01 0.285 0 0
G beta:gamma signalling through BTK R-HSA-8964315 5.187367e-01 0.285 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 5.187367e-01 0.285 0 0
Translesion synthesis by REV1 R-HSA-110312 5.187367e-01 0.285 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.187367e-01 0.285 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 5.191767e-01 0.285 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 5.191767e-01 0.285 0 0
ERK/MAPK targets R-HSA-198753 5.191767e-01 0.285 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 5.191767e-01 0.285 0 0
Early Phase of HIV Life Cycle R-HSA-162594 5.191767e-01 0.285 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 5.196805e-01 0.284 0 0
Cristae formation R-HSA-8949613 5.196805e-01 0.284 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 5.196805e-01 0.284 0 0
HIV Transcription Elongation R-HSA-167169 5.208008e-01 0.283 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 5.208008e-01 0.283 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 5.208008e-01 0.283 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 5.221510e-01 0.282 0 0
Adaptive Immune System R-HSA-1280218 5.268979e-01 0.278 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 5.285093e-01 0.277 0 0
Formation of paraxial mesoderm R-HSA-9793380 5.408513e-01 0.267 0 0
SARS-CoV-2 Infection R-HSA-9694516 5.417555e-01 0.266 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 5.418915e-01 0.266 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 5.427654e-01 0.265 0 0
FLT3 Signaling R-HSA-9607240 5.427654e-01 0.265 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 5.440145e-01 0.264 0 0
Signaling by NOTCH2 R-HSA-1980145 5.440145e-01 0.264 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 5.440145e-01 0.264 0 0
Telomere Extension By Telomerase R-HSA-171319 5.458338e-01 0.263 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 5.458338e-01 0.263 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 5.485853e-01 0.261 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 5.485853e-01 0.261 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 5.485853e-01 0.261 0 0
Translesion synthesis by POLI R-HSA-5656121 5.530341e-01 0.257 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 5.530341e-01 0.257 0 0
Killing mechanisms R-HSA-9664420 5.530341e-01 0.257 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.530341e-01 0.257 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.530341e-01 0.257 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 5.534636e-01 0.257 0 0
tRNA processing R-HSA-72306 5.534636e-01 0.257 0 0
UCH proteinases R-HSA-5689603 5.568569e-01 0.254 0 0
Folding of actin by CCT/TriC R-HSA-390450 5.611654e-01 0.251 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 5.611654e-01 0.251 0 0
DNA replication initiation R-HSA-68952 5.611654e-01 0.251 0 0
Receptor Mediated Mitophagy R-HSA-8934903 5.611654e-01 0.251 0 0
Regulation of the apoptosome activity R-HSA-9627069 5.611654e-01 0.251 0 0
Formation of apoptosome R-HSA-111458 5.611654e-01 0.251 0 0
MAPK3 (ERK1) activation R-HSA-110056 5.611654e-01 0.251 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 5.611654e-01 0.251 0 0
Negative regulation of MAPK pathway R-HSA-5675221 5.643008e-01 0.248 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 5.672648e-01 0.246 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 5.672648e-01 0.246 0 0
Transferrin endocytosis and recycling R-HSA-917977 5.672648e-01 0.246 0 0
PI Metabolism R-HSA-1483255 5.687404e-01 0.245 0 0
Late endosomal microautophagy R-HSA-9615710 5.712884e-01 0.243 0 0
Neutrophil degranulation R-HSA-6798695 5.746463e-01 0.241 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 5.752392e-01 0.240 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 5.770222e-01 0.239 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 5.770222e-01 0.239 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 5.781628e-01 0.238 0 0
Platelet degranulation R-HSA-114608 5.788699e-01 0.237 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 5.789543e-01 0.237 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 5.805016e-01 0.236 0 0
HCN channels R-HSA-1296061 5.805016e-01 0.236 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 5.805016e-01 0.236 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 5.805016e-01 0.236 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 5.805016e-01 0.236 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 5.805016e-01 0.236 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 5.805016e-01 0.236 0 0
NADE modulates death signalling R-HSA-205025 5.805016e-01 0.236 0 0
Toxicity of tetanus toxin (tetX) R-HSA-5250982 5.805016e-01 0.236 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 5.853613e-01 0.233 0 0
Ca-dependent events R-HSA-111996 5.853613e-01 0.233 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 5.858325e-01 0.232 0 0
Translesion synthesis by POLK R-HSA-5655862 5.858325e-01 0.232 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 5.858325e-01 0.232 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 5.858325e-01 0.232 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 5.858325e-01 0.232 0 0
tRNA modification in the mitochondrion R-HSA-6787450 5.858325e-01 0.232 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 5.858325e-01 0.232 0 0
Signaling by TGFB family members R-HSA-9006936 5.871612e-01 0.231 0 0
PCP/CE pathway R-HSA-4086400 5.891023e-01 0.230 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 5.899251e-01 0.229 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 5.913801e-01 0.228 0 0
Regulation of CDH1 Function R-HSA-9764561 5.972600e-01 0.224 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 6.012597e-01 0.221 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 6.012597e-01 0.221 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 6.012597e-01 0.221 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 6.012597e-01 0.221 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 6.012597e-01 0.221 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 6.012597e-01 0.221 0 0
vRNP Assembly R-HSA-192905 6.012597e-01 0.221 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 6.012597e-01 0.221 0 0
Suppression of apoptosis R-HSA-9635465 6.012597e-01 0.221 0 0
Prostanoid ligand receptors R-HSA-391908 6.012597e-01 0.221 0 0
ChREBP activates metabolic gene expression R-HSA-163765 6.012597e-01 0.221 0 0
Interleukin receptor SHC signaling R-HSA-912526 6.044102e-01 0.219 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 6.044102e-01 0.219 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 6.044102e-01 0.219 0 0
Termination of O-glycan biosynthesis R-HSA-977068 6.044102e-01 0.219 0 0
Cellular response to hypoxia R-HSA-1234174 6.111505e-01 0.214 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 6.119494e-01 0.213 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 6.119494e-01 0.213 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 6.170480e-01 0.210 0 0
Trafficking of AMPA receptors R-HSA-399719 6.198541e-01 0.208 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 6.198541e-01 0.208 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 6.198541e-01 0.208 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 6.199995e-01 0.208 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 6.211612e-01 0.207 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 6.211612e-01 0.207 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 6.306905e-01 0.200 0 0
Regulation of beta-cell development R-HSA-186712 6.326682e-01 0.199 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 6.332987e-01 0.198 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 6.354677e-01 0.197 0 0
FGFR1c and Klotho ligand binding and activation R-HSA-190374 6.370571e-01 0.196 0 0
Defective F9 activation R-HSA-9673221 6.370571e-01 0.196 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 6.370571e-01 0.196 0 0
Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) R-HSA-5619067 6.370571e-01 0.196 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 6.370571e-01 0.196 0 0
PTK6 Activates STAT3 R-HSA-8849474 6.370571e-01 0.196 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 6.370571e-01 0.196 0 0
PTK6 Down-Regulation R-HSA-8849472 6.370571e-01 0.196 0 0
Reelin signalling pathway R-HSA-8866376 6.370571e-01 0.196 0 0
NTRK2 activates RAC1 R-HSA-9032759 6.370571e-01 0.196 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 6.370571e-01 0.196 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.370571e-01 0.196 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 6.370571e-01 0.196 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 6.370571e-01 0.196 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 6.372804e-01 0.196 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.383818e-01 0.195 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 6.383818e-01 0.195 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 6.385226e-01 0.195 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 6.385226e-01 0.195 0 0
ERKs are inactivated R-HSA-202670 6.385226e-01 0.195 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 6.385226e-01 0.195 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 6.385226e-01 0.195 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 6.385226e-01 0.195 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 6.385226e-01 0.195 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 6.426140e-01 0.192 0 0
G0 and Early G1 R-HSA-1538133 6.428695e-01 0.192 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 6.428695e-01 0.192 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 6.453191e-01 0.190 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 6.453191e-01 0.190 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.466282e-01 0.189 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 6.466282e-01 0.189 0 0
Synaptic adhesion-like molecules R-HSA-8849932 6.466282e-01 0.189 0 0
PKA activation R-HSA-163615 6.466282e-01 0.189 0 0
Presynaptic function of Kainate receptors R-HSA-500657 6.466282e-01 0.189 0 0
Plasma lipoprotein clearance R-HSA-8964043 6.539414e-01 0.184 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 6.539414e-01 0.184 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 6.548563e-01 0.184 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 6.548563e-01 0.184 0 0
Acyl chain remodelling of PS R-HSA-1482801 6.558207e-01 0.183 0 0
Amino acids regulate mTORC1 R-HSA-9639288 6.562544e-01 0.183 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 6.589352e-01 0.181 0 0
Ub-specific processing proteases R-HSA-5689880 6.598632e-01 0.181 0 0
Transcription of the HIV genome R-HSA-167172 6.601582e-01 0.180 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 6.641321e-01 0.178 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 6.649934e-01 0.177 0 0
G-protein beta:gamma signalling R-HSA-397795 6.649934e-01 0.177 0 0
Regulation of necroptotic cell death R-HSA-5675482 6.649934e-01 0.177 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 6.649934e-01 0.177 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 6.649934e-01 0.177 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 6.649934e-01 0.177 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 6.649934e-01 0.177 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 6.663251e-01 0.176 0 0
GRB2 events in EGFR signaling R-HSA-179812 6.729888e-01 0.172 0 0
Scavenging by Class F Receptors R-HSA-3000484 6.729888e-01 0.172 0 0
Regulation of IFNG signaling R-HSA-877312 6.729888e-01 0.172 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 6.729888e-01 0.172 0 0
Interleukin-15 signaling R-HSA-8983432 6.729888e-01 0.172 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 6.729888e-01 0.172 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 6.735980e-01 0.172 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 6.738524e-01 0.171 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 6.738524e-01 0.171 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 6.738524e-01 0.171 0 0
Generation of second messenger molecules R-HSA-202433 6.738524e-01 0.171 0 0
Diseases of Immune System R-HSA-5260271 6.738524e-01 0.171 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 6.738524e-01 0.171 0 0
Interleukin-2 family signaling R-HSA-451927 6.738524e-01 0.171 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.745479e-01 0.171 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 6.745479e-01 0.171 0 0
Germ layer formation at gastrulation R-HSA-9754189 6.745479e-01 0.171 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.745479e-01 0.171 0 0
Regulation of signaling by CBL R-HSA-912631 6.745479e-01 0.171 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.745479e-01 0.171 0 0
The NLRP3 inflammasome R-HSA-844456 6.745479e-01 0.171 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.745479e-01 0.171 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 6.756843e-01 0.170 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 6.788897e-01 0.168 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 6.797737e-01 0.168 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 6.797737e-01 0.168 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 6.797737e-01 0.168 0 0
TRP channels R-HSA-3295583 6.797737e-01 0.168 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 6.823220e-01 0.166 0 0
Mitochondrial protein import R-HSA-1268020 6.824528e-01 0.166 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 6.826671e-01 0.166 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.859908e-01 0.164 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 6.859908e-01 0.164 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 6.859908e-01 0.164 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.859908e-01 0.164 0 0
Pentose phosphate pathway disease R-HSA-6791465 6.859908e-01 0.164 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.859908e-01 0.164 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 6.859908e-01 0.164 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.859908e-01 0.164 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 6.862029e-01 0.164 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 6.862029e-01 0.164 0 0
Effects of PIP2 hydrolysis R-HSA-114508 6.862029e-01 0.164 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 6.862029e-01 0.164 0 0
TCR signaling R-HSA-202403 6.867400e-01 0.163 0 0
COPII-mediated vesicle transport R-HSA-204005 6.907826e-01 0.161 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 6.930132e-01 0.159 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 6.930132e-01 0.159 0 0
Gastrulation R-HSA-9758941 6.995080e-01 0.155 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 7.008047e-01 0.154 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 7.008047e-01 0.154 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.008047e-01 0.154 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 7.008047e-01 0.154 0 0
Packaging Of Telomere Ends R-HSA-171306 7.025352e-01 0.153 0 0
Signaling by BMP R-HSA-201451 7.025352e-01 0.153 0 0
Insulin processing R-HSA-264876 7.025352e-01 0.153 0 0
SARS-CoV Infections R-HSA-9679506 7.026153e-01 0.153 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 7.029439e-01 0.153 0 0
Adenylate cyclase activating pathway R-HSA-170660 7.047348e-01 0.152 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 7.047348e-01 0.152 0 0
Formation of axial mesoderm R-HSA-9796292 7.047348e-01 0.152 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 7.047348e-01 0.152 0 0
CD28 dependent Vav1 pathway R-HSA-389359 7.047348e-01 0.152 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 7.047348e-01 0.152 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 7.047348e-01 0.152 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 7.047348e-01 0.152 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 7.047348e-01 0.152 0 0
Regulation of mitotic cell cycle R-HSA-453276 7.054429e-01 0.152 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 7.054429e-01 0.152 0 0
Hedgehog 'on' state R-HSA-5632684 7.054429e-01 0.152 0 0
Mitophagy R-HSA-5205647 7.064836e-01 0.151 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 7.064836e-01 0.151 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 7.064836e-01 0.151 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 7.065549e-01 0.151 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 7.114110e-01 0.148 0 0
HIV Transcription Initiation R-HSA-167161 7.114110e-01 0.148 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 7.114110e-01 0.148 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.124660e-01 0.147 0 0
Signaling by Insulin receptor R-HSA-74752 7.132308e-01 0.147 0 0
Ion transport by P-type ATPases R-HSA-936837 7.132432e-01 0.147 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 7.196569e-01 0.143 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 7.241031e-01 0.140 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 7.241031e-01 0.140 0 0
Formation of the Early Elongation Complex R-HSA-113418 7.241031e-01 0.140 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 7.254151e-01 0.139 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.254151e-01 0.139 0 0
Basigin interactions R-HSA-210991 7.254151e-01 0.139 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 7.254151e-01 0.139 0 0
VLDL assembly R-HSA-8866423 7.283294e-01 0.138 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 7.283294e-01 0.138 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 7.283294e-01 0.138 0 0
MET Receptor Activation R-HSA-6806942 7.283294e-01 0.138 0 0
Metabolism of vitamin K R-HSA-6806664 7.283294e-01 0.138 0 0
HDL clearance R-HSA-8964011 7.283294e-01 0.138 0 0
Neurofascin interactions R-HSA-447043 7.283294e-01 0.138 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 7.283294e-01 0.138 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 7.338677e-01 0.134 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 7.338677e-01 0.134 0 0
Physiological factors R-HSA-5578768 7.338677e-01 0.134 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 7.338677e-01 0.134 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.354327e-01 0.133 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 7.377840e-01 0.132 0 0
rRNA processing R-HSA-72312 7.417660e-01 0.130 0 0
Diseases of programmed cell death R-HSA-9645723 7.441967e-01 0.128 0 0
PRC2 methylates histones and DNA R-HSA-212300 7.442380e-01 0.128 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 7.444851e-01 0.128 0 0
DNA methylation R-HSA-5334118 7.444851e-01 0.128 0 0
mRNA Capping R-HSA-72086 7.444851e-01 0.128 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 7.444851e-01 0.128 0 0
DARPP-32 events R-HSA-180024 7.444851e-01 0.128 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 7.458757e-01 0.127 0 0
Parasite infection R-HSA-9664407 7.458757e-01 0.127 0 0
Leishmania phagocytosis R-HSA-9664417 7.458757e-01 0.127 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.458935e-01 0.127 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.484111e-01 0.126 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 7.484111e-01 0.126 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 7.484111e-01 0.126 0 0
Triglyceride metabolism R-HSA-8979227 7.519510e-01 0.124 0 0
PPARA activates gene expression R-HSA-1989781 7.566736e-01 0.121 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 7.605149e-01 0.119 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 7.605149e-01 0.119 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 7.605149e-01 0.119 0 0
Telomere C-strand synthesis initiation R-HSA-174430 7.605149e-01 0.119 0 0
FASTK family proteins regulate processing and stability of mitochondrial RNAs R-HSA-9837092 7.605149e-01 0.119 0 0
SHC1 events in EGFR signaling R-HSA-180336 7.605149e-01 0.119 0 0
Protein methylation R-HSA-8876725 7.605149e-01 0.119 0 0
Cleavage of the damaged purine R-HSA-110331 7.617182e-01 0.118 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 7.619781e-01 0.118 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 7.649615e-01 0.116 0 0
Disinhibition of SNARE formation R-HSA-114516 7.649615e-01 0.116 0 0
Recycling of eIF2:GDP R-HSA-72731 7.649615e-01 0.116 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 7.649615e-01 0.116 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 7.649615e-01 0.116 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 7.649615e-01 0.116 0 0
LDL remodeling R-HSA-8964041 7.649615e-01 0.116 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 7.649615e-01 0.116 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.649615e-01 0.116 0 0
CHL1 interactions R-HSA-447041 7.649615e-01 0.116 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.698374e-01 0.114 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 7.698374e-01 0.114 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 7.698374e-01 0.114 0 0
Opioid Signalling R-HSA-111885 7.758379e-01 0.110 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.772983e-01 0.109 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 7.772983e-01 0.109 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 7.772983e-01 0.109 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 7.778186e-01 0.109 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 7.778186e-01 0.109 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.778186e-01 0.109 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 7.779731e-01 0.109 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 7.782810e-01 0.109 0 0
Depurination R-HSA-73927 7.782810e-01 0.109 0 0
PLC beta mediated events R-HSA-112043 7.792889e-01 0.108 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.817648e-01 0.107 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 7.838829e-01 0.106 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 7.848168e-01 0.105 0 0
Phosphorylation of the APC/C R-HSA-176412 7.848168e-01 0.105 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 7.848168e-01 0.105 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 7.848168e-01 0.105 0 0
Prolonged ERK activation events R-HSA-169893 7.848168e-01 0.105 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 7.848168e-01 0.105 0 0
Differentiation of T cells R-HSA-9945266 7.848168e-01 0.105 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 7.865177e-01 0.104 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 7.897481e-01 0.103 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 7.918640e-01 0.101 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 7.934811e-01 0.100 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 7.934811e-01 0.100 0 0
RSK activation R-HSA-444257 7.966560e-01 0.099 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.966560e-01 0.099 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 7.966560e-01 0.099 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 7.966560e-01 0.099 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 7.966560e-01 0.099 0 0
Regulation by c-FLIP R-HSA-3371378 7.966560e-01 0.099 0 0
Fructose biosynthesis R-HSA-5652227 7.966560e-01 0.099 0 0
Co-stimulation by ICOS R-HSA-9927354 7.966560e-01 0.099 0 0
Interleukin-9 signaling R-HSA-8985947 7.966560e-01 0.099 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.966560e-01 0.099 0 0
Dimerization of procaspase-8 R-HSA-69416 7.966560e-01 0.099 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.966560e-01 0.099 0 0
Adrenoceptors R-HSA-390696 7.966560e-01 0.099 0 0
Alpha-defensins R-HSA-1462054 7.966560e-01 0.099 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.966560e-01 0.099 0 0
Sodium/Proton exchangers R-HSA-425986 7.966560e-01 0.099 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 7.966560e-01 0.099 0 0
Signaling by WNT in cancer R-HSA-4791275 7.987163e-01 0.098 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.043542e-01 0.095 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 8.044326e-01 0.095 0 0
G alpha (z) signalling events R-HSA-418597 8.044326e-01 0.095 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 8.069214e-01 0.093 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 8.069214e-01 0.093 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 8.069214e-01 0.093 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 8.069214e-01 0.093 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 8.069214e-01 0.093 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 8.082047e-01 0.092 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 8.082047e-01 0.092 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 8.087235e-01 0.092 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.087235e-01 0.092 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.145870e-01 0.089 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.167907e-01 0.088 0 0
Ion homeostasis R-HSA-5578775 8.167907e-01 0.088 0 0
GPER1 signaling R-HSA-9634597 8.187857e-01 0.087 0 0
Mitochondrial protein degradation R-HSA-9837999 8.196979e-01 0.086 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.197333e-01 0.086 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.217309e-01 0.085 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.226470e-01 0.085 0 0
Co-inhibition by PD-1 R-HSA-389948 8.230724e-01 0.085 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 8.234609e-01 0.084 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 8.234609e-01 0.084 0 0
ARMS-mediated activation R-HSA-170984 8.240781e-01 0.084 0 0
CASP8 activity is inhibited R-HSA-5218900 8.240781e-01 0.084 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 8.240781e-01 0.084 0 0
Hypusine synthesis from eIF5A-lysine R-HSA-204626 8.240781e-01 0.084 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 8.240781e-01 0.084 0 0
mRNA Editing R-HSA-75072 8.240781e-01 0.084 0 0
Regulation of signaling by NODAL R-HSA-1433617 8.240781e-01 0.084 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 8.240781e-01 0.084 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 8.240781e-01 0.084 0 0
Interleukin-1 processing R-HSA-448706 8.240781e-01 0.084 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.240781e-01 0.084 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.252739e-01 0.083 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.252739e-01 0.083 0 0
TGFBR3 expression R-HSA-9839394 8.252739e-01 0.083 0 0
Formation of the nephric duct R-HSA-9830364 8.252739e-01 0.083 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 8.269793e-01 0.083 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.269793e-01 0.083 0 0
Sulfide oxidation to sulfate R-HSA-1614517 8.269793e-01 0.083 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.269793e-01 0.083 0 0
IRS-mediated signalling R-HSA-112399 8.285328e-01 0.082 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 8.294156e-01 0.081 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.310957e-01 0.080 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 8.357397e-01 0.078 0 0
Intra-Golgi traffic R-HSA-6811438 8.357397e-01 0.078 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.410259e-01 0.075 0 0
Eukaryotic Translation Initiation R-HSA-72613 8.417421e-01 0.075 0 0
Cap-dependent Translation Initiation R-HSA-72737 8.417421e-01 0.075 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.432438e-01 0.074 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 8.432438e-01 0.074 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 8.432438e-01 0.074 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.432438e-01 0.074 0 0
Polo-like kinase mediated events R-HSA-156711 8.451403e-01 0.073 0 0
PKA activation in glucagon signalling R-HSA-164378 8.451403e-01 0.073 0 0
Apoptotic factor-mediated response R-HSA-111471 8.451403e-01 0.073 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 8.451403e-01 0.073 0 0
Protein ubiquitination R-HSA-8852135 8.466101e-01 0.072 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.478036e-01 0.072 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 8.478036e-01 0.072 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 8.478036e-01 0.072 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 8.478036e-01 0.072 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 8.478036e-01 0.072 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 8.478036e-01 0.072 0 0
Arachidonate production from DAG R-HSA-426048 8.478036e-01 0.072 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 8.478036e-01 0.072 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 8.478036e-01 0.072 0 0
G-protein mediated events R-HSA-112040 8.479209e-01 0.072 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 8.480301e-01 0.072 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.480301e-01 0.072 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.480301e-01 0.072 0 0
Depyrimidination R-HSA-73928 8.480301e-01 0.072 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 8.539109e-01 0.069 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 8.555330e-01 0.068 0 0
Interaction between L1 and Ankyrins R-HSA-445095 8.555330e-01 0.068 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 8.555330e-01 0.068 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 8.555330e-01 0.068 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 8.555330e-01 0.068 0 0
Maturation of hRSV A proteins R-HSA-9828806 8.555330e-01 0.068 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 8.561154e-01 0.067 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 8.615513e-01 0.065 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 8.615513e-01 0.065 0 0
Specification of the neural plate border R-HSA-9834899 8.615513e-01 0.065 0 0
Maturation of nucleoprotein R-HSA-9694631 8.615513e-01 0.065 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.615513e-01 0.065 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 8.643009e-01 0.063 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 8.643009e-01 0.063 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.680756e-01 0.061 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.680756e-01 0.061 0 0
Chylomicron assembly R-HSA-8963888 8.683305e-01 0.061 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 8.683305e-01 0.061 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 8.683305e-01 0.061 0 0
Synthesis of PI R-HSA-1483226 8.683305e-01 0.061 0 0
Transport of RCbl within the body R-HSA-9758890 8.683305e-01 0.061 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.683305e-01 0.061 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.683305e-01 0.061 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.683305e-01 0.061 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.688680e-01 0.061 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 8.688680e-01 0.061 0 0
Pyrimidine salvage R-HSA-73614 8.688680e-01 0.061 0 0
Inflammasomes R-HSA-622312 8.688680e-01 0.061 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.688680e-01 0.061 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.696509e-01 0.061 0 0
Platelet homeostasis R-HSA-418346 8.699317e-01 0.061 0 0
SARS-CoV-1-host interactions R-HSA-9692914 8.699317e-01 0.061 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 8.740705e-01 0.058 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 8.752259e-01 0.058 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 8.763538e-01 0.057 0 0
Signaling by NODAL R-HSA-1181150 8.763538e-01 0.057 0 0
Pregnenolone biosynthesis R-HSA-196108 8.763538e-01 0.057 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 8.763538e-01 0.057 0 0
Degradation of DVL R-HSA-4641258 8.791704e-01 0.056 0 0
Degradation of AXIN R-HSA-4641257 8.791704e-01 0.056 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 8.803954e-01 0.055 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 8.803954e-01 0.055 0 0
HCMV Late Events R-HSA-9610379 8.810031e-01 0.055 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 8.811038e-01 0.055 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 8.811038e-01 0.055 0 0
Regulation of gene expression in beta cells R-HSA-210745 8.811038e-01 0.055 0 0
Glucagon-type ligand receptors R-HSA-420092 8.811038e-01 0.055 0 0
Platelet calcium homeostasis R-HSA-418360 8.811038e-01 0.055 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 8.832440e-01 0.054 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 8.832440e-01 0.054 0 0
Scavenging by Class H Receptors R-HSA-3000497 8.860900e-01 0.053 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.860900e-01 0.053 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 8.860900e-01 0.053 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.860900e-01 0.053 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.860900e-01 0.053 0 0
Anchoring fibril formation R-HSA-2214320 8.860900e-01 0.053 0 0
DS-GAG biosynthesis R-HSA-2022923 8.860900e-01 0.053 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.864348e-01 0.052 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 8.883231e-01 0.051 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.894459e-01 0.051 0 0
G-protein activation R-HSA-202040 8.896831e-01 0.051 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 8.896831e-01 0.051 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 8.896831e-01 0.051 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 8.896831e-01 0.051 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 8.897892e-01 0.051 0 0
Ion channel transport R-HSA-983712 8.905580e-01 0.050 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 8.910896e-01 0.050 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.923120e-01 0.049 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.923120e-01 0.049 0 0
Muscle contraction R-HSA-397014 8.941149e-01 0.049 0 0
Insulin receptor signalling cascade R-HSA-74751 8.948483e-01 0.048 0 0
IGF1R signaling cascade R-HSA-2428924 8.948483e-01 0.048 0 0
Ca2+ pathway R-HSA-4086398 8.983675e-01 0.047 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 8.985407e-01 0.046 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 8.989483e-01 0.046 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 8.989483e-01 0.046 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 9.014550e-01 0.045 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 9.014550e-01 0.045 0 0
VLDLR internalisation and degradation R-HSA-8866427 9.014550e-01 0.045 0 0
Proline catabolism R-HSA-70688 9.014550e-01 0.045 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 9.014550e-01 0.045 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 9.014550e-01 0.045 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 9.014550e-01 0.045 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 9.014550e-01 0.045 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 9.014550e-01 0.045 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 9.014550e-01 0.045 0 0
Estrogen biosynthesis R-HSA-193144 9.014550e-01 0.045 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 9.014550e-01 0.045 0 0
OAS antiviral response R-HSA-8983711 9.014550e-01 0.045 0 0
Attachment and Entry R-HSA-9694614 9.016672e-01 0.045 0 0
Glutathione synthesis and recycling R-HSA-174403 9.016672e-01 0.045 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.022764e-01 0.045 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.025625e-01 0.045 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.025625e-01 0.045 0 0
Immune System R-HSA-168256 9.042909e-01 0.044 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.052314e-01 0.043 0 0
Downstream TCR signaling R-HSA-202424 9.060493e-01 0.043 0 0
Neurotransmitter release cycle R-HSA-112310 9.060493e-01 0.043 0 0
RSV-host interactions R-HSA-9833110 9.084469e-01 0.042 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.085096e-01 0.042 0 0
Viral Infection Pathways R-HSA-9824446 9.119001e-01 0.040 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.119230e-01 0.040 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 9.124264e-01 0.040 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.124264e-01 0.040 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.124264e-01 0.040 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.124264e-01 0.040 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.124264e-01 0.040 0 0
Cellular hexose transport R-HSA-189200 9.124264e-01 0.040 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.124264e-01 0.040 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.144781e-01 0.039 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.144781e-01 0.039 0 0
Chylomicron remodeling R-HSA-8963901 9.147482e-01 0.039 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 9.147482e-01 0.039 0 0
FGFR2c ligand binding and activation R-HSA-190375 9.147482e-01 0.039 0 0
FGFR1c ligand binding and activation R-HSA-190373 9.147482e-01 0.039 0 0
FGFR4 ligand binding and activation R-HSA-190322 9.147482e-01 0.039 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 9.147482e-01 0.039 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 9.147482e-01 0.039 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 9.147482e-01 0.039 0 0
FGFR3 mutant receptor activation R-HSA-2033514 9.147482e-01 0.039 0 0
rRNA modification in the mitochondrion R-HSA-6793080 9.147482e-01 0.039 0 0
Frs2-mediated activation R-HSA-170968 9.147482e-01 0.039 0 0
Maturation of nucleoprotein R-HSA-9683610 9.147482e-01 0.039 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.158138e-01 0.038 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.169948e-01 0.038 0 0
PI3K Cascade R-HSA-109704 9.212671e-01 0.036 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.212900e-01 0.036 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.220732e-01 0.035 0 0
Interleukin-20 family signaling R-HSA-8854691 9.220732e-01 0.035 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.220732e-01 0.035 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 9.220732e-01 0.035 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 9.220732e-01 0.035 0 0
Cellular response to starvation R-HSA-9711097 9.231658e-01 0.035 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.232647e-01 0.035 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.232647e-01 0.035 0 0
Prolactin receptor signaling R-HSA-1170546 9.262489e-01 0.033 0 0
FGFR3c ligand binding and activation R-HSA-190372 9.262489e-01 0.033 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 9.262489e-01 0.033 0 0
Retrograde neurotrophin signalling R-HSA-177504 9.262489e-01 0.033 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 9.262489e-01 0.033 0 0
cGMP effects R-HSA-418457 9.262489e-01 0.033 0 0
Malate-aspartate shuttle R-HSA-9856872 9.262489e-01 0.033 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.262489e-01 0.033 0 0
Zinc transporters R-HSA-435354 9.262489e-01 0.033 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.269288e-01 0.033 0 0
GABA receptor activation R-HSA-977443 9.271701e-01 0.033 0 0
RAB geranylgeranylation R-HSA-8873719 9.271701e-01 0.033 0 0
tRNA Aminoacylation R-HSA-379724 9.271701e-01 0.033 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.277732e-01 0.033 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 9.282311e-01 0.032 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.282311e-01 0.032 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.282311e-01 0.032 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 9.284098e-01 0.032 0 0
Activation of GABAB receptors R-HSA-991365 9.301173e-01 0.031 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 9.301173e-01 0.031 0 0
GABA B receptor activation R-HSA-977444 9.301173e-01 0.031 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.301173e-01 0.031 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 9.302508e-01 0.031 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.307116e-01 0.031 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.307116e-01 0.031 0 0
Complex III assembly R-HSA-9865881 9.307116e-01 0.031 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.337961e-01 0.030 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 9.337961e-01 0.030 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.352999e-01 0.029 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 9.361987e-01 0.029 0 0
Protein lipoylation R-HSA-9857492 9.361987e-01 0.029 0 0
FGFR3 ligand binding and activation R-HSA-190239 9.361987e-01 0.029 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 9.361987e-01 0.029 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 9.361987e-01 0.029 0 0
Other semaphorin interactions R-HSA-416700 9.361987e-01 0.029 0 0
Formation of the anterior neural plate R-HSA-9823739 9.361987e-01 0.029 0 0
DNA Damage Reversal R-HSA-73942 9.361987e-01 0.029 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.364119e-01 0.029 0 0
Defective pyroptosis R-HSA-9710421 9.364119e-01 0.029 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.364119e-01 0.029 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.380526e-01 0.028 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.381726e-01 0.028 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.381726e-01 0.028 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.384382e-01 0.028 0 0
G protein gated Potassium channels R-HSA-1296059 9.384382e-01 0.028 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.384382e-01 0.028 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.384382e-01 0.028 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.384382e-01 0.028 0 0
Tight junction interactions R-HSA-420029 9.384382e-01 0.028 0 0
Laminin interactions R-HSA-3000157 9.384382e-01 0.028 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.384382e-01 0.028 0 0
Smooth Muscle Contraction R-HSA-445355 9.393654e-01 0.027 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.394800e-01 0.027 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.411448e-01 0.026 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.417208e-01 0.026 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.417208e-01 0.026 0 0
Regulation of Apoptosis R-HSA-169911 9.417208e-01 0.026 0 0
Amine ligand-binding receptors R-HSA-375280 9.421869e-01 0.026 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.427711e-01 0.026 0 0
ER-Phagosome pathway R-HSA-1236974 9.439150e-01 0.025 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 9.448066e-01 0.025 0 0
Atorvastatin ADME R-HSA-9754706 9.448066e-01 0.025 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.448066e-01 0.025 0 0
Activation of the phototransduction cascade R-HSA-2485179 9.448066e-01 0.025 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 9.448066e-01 0.025 0 0
Attachment and Entry R-HSA-9678110 9.448066e-01 0.025 0 0
MET activates PTK2 signaling R-HSA-8874081 9.453418e-01 0.024 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.453418e-01 0.024 0 0
Sphingolipid catabolism R-HSA-9845614 9.453418e-01 0.024 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.453418e-01 0.024 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.474794e-01 0.023 0 0
Somitogenesis R-HSA-9824272 9.474794e-01 0.023 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.475463e-01 0.023 0 0
G1/S-Specific Transcription R-HSA-69205 9.475463e-01 0.023 0 0
Cellular response to chemical stress R-HSA-9711123 9.492136e-01 0.023 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 9.522536e-01 0.021 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.522536e-01 0.021 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.522536e-01 0.021 0 0
Scavenging by Class B Receptors R-HSA-3000471 9.522536e-01 0.021 0 0
Phase 2 - plateau phase R-HSA-5576893 9.522536e-01 0.021 0 0
Glycine degradation R-HSA-6783984 9.522536e-01 0.021 0 0
Fibronectin matrix formation R-HSA-1566977 9.522536e-01 0.021 0 0
Formation of xylulose-5-phosphate R-HSA-5661270 9.522536e-01 0.021 0 0
Galactose catabolism R-HSA-70370 9.522536e-01 0.021 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.522536e-01 0.021 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.522536e-01 0.021 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.523242e-01 0.021 0 0
Signaling by TGFBR3 R-HSA-9839373 9.523242e-01 0.021 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.528256e-01 0.021 0 0
Collagen chain trimerization R-HSA-8948216 9.528256e-01 0.021 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.549643e-01 0.020 0 0
Integration of energy metabolism R-HSA-163685 9.558977e-01 0.020 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.565650e-01 0.019 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 9.569983e-01 0.019 0 0
Dectin-2 family R-HSA-5621480 9.576591e-01 0.019 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.586962e-01 0.018 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 9.586962e-01 0.018 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.586962e-01 0.018 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.586962e-01 0.018 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.586962e-01 0.018 0 0
Leishmania infection R-HSA-9658195 9.596289e-01 0.018 0 0
Parasitic Infection Pathways R-HSA-9824443 9.596289e-01 0.018 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.618935e-01 0.017 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.619273e-01 0.017 0 0
Regulated Necrosis R-HSA-5218859 9.628292e-01 0.016 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 9.642698e-01 0.016 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.642698e-01 0.016 0 0
Activated point mutants of FGFR2 R-HSA-2033519 9.642698e-01 0.016 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.642698e-01 0.016 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.642698e-01 0.016 0 0
Integrin cell surface interactions R-HSA-216083 9.647607e-01 0.016 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.647705e-01 0.016 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.658324e-01 0.015 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.662510e-01 0.015 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.675736e-01 0.014 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.690916e-01 0.014 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.690916e-01 0.014 0 0
Diseases of hemostasis R-HSA-9671793 9.690916e-01 0.014 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.690916e-01 0.014 0 0
Crosslinking of collagen fibrils R-HSA-2243919 9.690916e-01 0.014 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.693399e-01 0.014 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.693574e-01 0.014 0 0
Budding and maturation of HIV virion R-HSA-162588 9.701267e-01 0.013 0 0
SLC transporter disorders R-HSA-5619102 9.706914e-01 0.013 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.716973e-01 0.012 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.725363e-01 0.012 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.725363e-01 0.012 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.732629e-01 0.012 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.732629e-01 0.012 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.732629e-01 0.012 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.732629e-01 0.012 0 0
Creatine metabolism R-HSA-71288 9.732629e-01 0.012 0 0
Synthesis of Ketone Bodies R-HSA-77111 9.732629e-01 0.012 0 0
Protein hydroxylation R-HSA-9629569 9.732629e-01 0.012 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.735713e-01 0.012 0 0
Regulation of insulin secretion R-HSA-422356 9.755555e-01 0.011 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.766305e-01 0.010 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.768715e-01 0.010 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.768715e-01 0.010 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.768715e-01 0.010 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.768715e-01 0.010 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.768715e-01 0.010 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.768715e-01 0.010 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.768715e-01 0.010 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.788270e-01 0.009 0 0
Stimuli-sensing channels R-HSA-2672351 9.788270e-01 0.009 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.796914e-01 0.009 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.796914e-01 0.009 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.799932e-01 0.009 0 0
Ribavirin ADME R-HSA-9755088 9.799932e-01 0.009 0 0
Assembly Of The HIV Virion R-HSA-175474 9.799932e-01 0.009 0 0
Iron uptake and transport R-HSA-917937 9.800736e-01 0.009 0 0
Proteasome assembly R-HSA-9907900 9.802995e-01 0.009 0 0
Surfactant metabolism R-HSA-5683826 9.802995e-01 0.009 0 0
Selenocysteine synthesis R-HSA-2408557 9.807372e-01 0.008 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.813145e-01 0.008 0 0
eNOS activation R-HSA-203615 9.817536e-01 0.008 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 9.817536e-01 0.008 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.821846e-01 0.008 0 0
Nucleosome assembly R-HSA-774815 9.823850e-01 0.008 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 9.823850e-01 0.008 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 9.826937e-01 0.008 0 0
Fructose metabolism R-HSA-5652084 9.826937e-01 0.008 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.826937e-01 0.008 0 0
Collagen formation R-HSA-1474290 9.828170e-01 0.008 0 0
Interferon gamma signaling R-HSA-877300 9.835900e-01 0.007 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.842582e-01 0.007 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.842582e-01 0.007 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.850299e-01 0.007 0 0
Formation of the ureteric bud R-HSA-9830674 9.850299e-01 0.007 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.850299e-01 0.007 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.850299e-01 0.007 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.850299e-01 0.007 0 0
Ketone body metabolism R-HSA-74182 9.850299e-01 0.007 0 0
Biosynthesis of maresins R-HSA-9018682 9.850299e-01 0.007 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.850778e-01 0.007 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.854559e-01 0.006 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.854920e-01 0.006 0 0
Eukaryotic Translation Termination R-HSA-72764 9.854920e-01 0.006 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.857790e-01 0.006 0 0
Peptide chain elongation R-HSA-156902 9.863321e-01 0.006 0 0
Protein localization R-HSA-9609507 9.864268e-01 0.006 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.870508e-01 0.006 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.874480e-01 0.005 0 0
Gluconeogenesis R-HSA-70263 9.874480e-01 0.005 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.874531e-01 0.005 0 0
NCAM1 interactions R-HSA-419037 9.874531e-01 0.005 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.885333e-01 0.005 0 0
Glutathione conjugation R-HSA-156590 9.885333e-01 0.005 0 0
Amyloid fiber formation R-HSA-977225 9.885828e-01 0.005 0 0
Hyaluronan degradation R-HSA-2160916 9.887990e-01 0.005 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.887990e-01 0.005 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.889345e-01 0.005 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.891449e-01 0.005 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.895626e-01 0.005 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.895982e-01 0.005 0 0
Aquaporin-mediated transport R-HSA-445717 9.896878e-01 0.005 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 9.899635e-01 0.004 0 0
Azathioprine ADME R-HSA-9748787 9.900113e-01 0.004 0 0
Pentose phosphate pathway R-HSA-71336 9.902448e-01 0.004 0 0
Attachment of bacteria to epithelial cells R-HSA-9638630 9.903112e-01 0.004 0 0
Urea cycle R-HSA-70635 9.903112e-01 0.004 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.903112e-01 0.004 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.905569e-01 0.004 0 0
ABC-family proteins mediated transport R-HSA-382556 9.905789e-01 0.004 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.914030e-01 0.004 0 0
Glycogen metabolism R-HSA-8982491 9.914030e-01 0.004 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.914030e-01 0.004 0 0
Triglyceride biosynthesis R-HSA-75109 9.916194e-01 0.004 0 0
Synthesis of PE R-HSA-1483213 9.916194e-01 0.004 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.924264e-01 0.003 0 0
Maturation of spike protein R-HSA-9694548 9.924264e-01 0.003 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.925216e-01 0.003 0 0
Pyroptosis R-HSA-5620971 9.927510e-01 0.003 0 0
Prednisone ADME R-HSA-9757110 9.927510e-01 0.003 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.929951e-01 0.003 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.933302e-01 0.003 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.934053e-01 0.003 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.937299e-01 0.003 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.939778e-01 0.003 0 0
Pyruvate metabolism R-HSA-70268 9.941744e-01 0.003 0 0
Paracetamol ADME R-HSA-9753281 9.944018e-01 0.002 0 0
ABC transporter disorders R-HSA-5619084 9.945459e-01 0.002 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.950203e-01 0.002 0 0
O-linked glycosylation of mucins R-HSA-913709 9.951591e-01 0.002 0 0
Developmental Cell Lineages R-HSA-9734767 9.952214e-01 0.002 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.953091e-01 0.002 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.953091e-01 0.002 0 0
Synthesis of PA R-HSA-1483166 9.955722e-01 0.002 0 0
Neddylation R-HSA-8951664 9.957008e-01 0.002 0 0
HS-GAG degradation R-HSA-2024096 9.959426e-01 0.002 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.960009e-01 0.002 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.960009e-01 0.002 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.960040e-01 0.002 0 0
Innate Immune System R-HSA-168249 9.962706e-01 0.002 0 0
IRE1alpha activates chaperones R-HSA-381070 9.964464e-01 0.002 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.964835e-01 0.002 0 0
Retinoid metabolism and transport R-HSA-975634 9.965221e-01 0.002 0 0
ECM proteoglycans R-HSA-3000178 9.965221e-01 0.002 0 0
Metabolism of polyamines R-HSA-351202 9.968943e-01 0.001 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.969647e-01 0.001 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.969647e-01 0.001 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.970130e-01 0.001 0 0
Viral mRNA Translation R-HSA-192823 9.971936e-01 0.001 0 0
Nucleotide salvage R-HSA-8956321 9.972426e-01 0.001 0 0
Collagen degradation R-HSA-1442490 9.972426e-01 0.001 0 0
Metal ion SLC transporters R-HSA-425410 9.972834e-01 0.001 0 0
Ribosome-associated quality control R-HSA-9948299 9.973421e-01 0.001 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.973747e-01 0.001 0 0
Hyaluronan metabolism R-HSA-2142845 9.973747e-01 0.001 0 0
RA biosynthesis pathway R-HSA-5365859 9.973747e-01 0.001 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.973747e-01 0.001 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.975351e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.976132e-01 0.001 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.976132e-01 0.001 0 0
Cardiac conduction R-HSA-5576891 9.977409e-01 0.001 0 0
XBP1(S) activates chaperone genes R-HSA-381038 9.978788e-01 0.001 0 0
HS-GAG biosynthesis R-HSA-2022928 9.980361e-01 0.001 0 0
Post-translational protein modification R-HSA-597592 9.980898e-01 0.001 0 0
The phototransduction cascade R-HSA-2514856 9.981590e-01 0.001 0 0
Interferon alpha/beta signaling R-HSA-909733 9.981830e-01 0.001 0 0
Translation of Structural Proteins R-HSA-9694635 9.982238e-01 0.001 0 0
Voltage gated Potassium channels R-HSA-1296072 9.983014e-01 0.001 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.983014e-01 0.001 0 0
Metabolism of folate and pterines R-HSA-196757 9.983014e-01 0.001 0 0
Peptide hormone metabolism R-HSA-2980736 9.984985e-01 0.001 0 0
Elastic fibre formation R-HSA-1566948 9.985309e-01 0.001 0 0
Biofilm formation R-HSA-9931953 9.985309e-01 0.001 0 0
Purine salvage R-HSA-74217 9.985309e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.986257e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.986257e-01 0.001 0 0
Kidney development R-HSA-9830369 9.986588e-01 0.001 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.986588e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.986588e-01 0.001 0 0
RAS processing R-HSA-9648002 9.987294e-01 0.001 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.990496e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.991071e-01 0.000 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.991781e-01 0.000 0 0
Heme biosynthesis R-HSA-189451 9.991781e-01 0.000 0 0
Translation of Structural Proteins R-HSA-9683701 9.991781e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.992381e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.992833e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.993542e-01 0.000 0 0
Defensins R-HSA-1461973 9.993852e-01 0.000 0 0
Pyrimidine catabolism R-HSA-73621 9.993852e-01 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 9.993975e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.994221e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.994253e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.994293e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.994331e-01 0.000 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.994339e-01 0.000 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.994683e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.994954e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.996193e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.996518e-01 0.000 0 0
Synthesis of PC R-HSA-1483191 9.996561e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.996666e-01 0.000 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.997518e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.997762e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.998077e-01 0.000 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.998077e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.998077e-01 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 9.998562e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.998630e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.998688e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.998917e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.998924e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.998996e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999140e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999318e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.999399e-01 0.000 0 0
Peroxisomal protein import R-HSA-9033241 9.999399e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.999399e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999487e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.999487e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999530e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.999550e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999623e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999718e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.999848e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999848e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.999879e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999879e-01 0.000 0 0
Classical antibody-mediated complement activation R-HSA-173623 9.999884e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999886e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.999895e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.999909e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999914e-01 0.000 0 0
Disease R-HSA-1643685 9.999921e-01 0.000 1 0
Aspirin ADME R-HSA-9749641 9.999921e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999955e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999961e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999966e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999967e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999968e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999969e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999971e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999975e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999980e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999986e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999991e-01 0.000 0 0
Creation of C4 and C2 activators R-HSA-166786 9.999993e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999996e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999996e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999997e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.999998e-01 0.000 0 0
Translation R-HSA-72766 9.999999e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999999e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999999e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999999e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
G alpha (i) signalling events R-HSA-418594 1.000000e+00 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 1.062954e-09 8.973 1 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 3.101818e-09 8.508 1 1
DNA Double-Strand Break Repair R-HSA-5693532 1.145609e-08 7.941 1 0
Homology Directed Repair R-HSA-5693538 6.719268e-07 6.173 1 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 7.570571e-07 6.121 1 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.184177e-06 5.661 1 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.579093e-06 5.446 1 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 3.581049e-06 5.446 1 0
Cell Cycle, Mitotic R-HSA-69278 3.454773e-06 5.462 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 3.581049e-06 5.446 1 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 4.411316e-06 5.355 1 0
Regulation of TP53 Activity R-HSA-5633007 7.233211e-06 5.141 1 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 7.786462e-06 5.109 1 1
DNA Repair R-HSA-73894 7.557183e-06 5.122 1 0
Diseases of DNA repair R-HSA-9675135 9.912650e-06 5.004 1 0
Chromatin organization R-HSA-4839726 1.404966e-05 4.852 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.898552e-05 4.722 1 1
Chromatin modifying enzymes R-HSA-3247509 2.386711e-05 4.622 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.066482e-05 4.513 1 1
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.678560e-05 4.434 1 1
Cell Cycle Checkpoints R-HSA-69620 6.264481e-05 4.203 1 0
Oncogene Induced Senescence R-HSA-2559585 6.954653e-05 4.158 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 7.564992e-05 4.121 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.077267e-04 3.968 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.077267e-04 3.968 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.077267e-04 3.968 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.077267e-04 3.968 0 0
G2/M Checkpoints R-HSA-69481 1.023019e-04 3.990 1 0
G2/M DNA damage checkpoint R-HSA-69473 1.156378e-04 3.937 1 1
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 1.735127e-04 3.761 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.307426e-04 3.637 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.394479e-04 3.621 0 0
Cellular Senescence R-HSA-2559583 3.256349e-04 3.487 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.506376e-04 3.455 1 1
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.784632e-04 3.422 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 3.780777e-04 3.422 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 3.930494e-04 3.406 0 0
Gene expression (Transcription) R-HSA-74160 4.198348e-04 3.377 1 0
Resolution of D-Loop Structures R-HSA-5693537 4.961467e-04 3.304 0 0
RNA Polymerase II Transcription R-HSA-73857 5.189018e-04 3.285 1 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 5.812712e-04 3.236 0 0
NRAGE signals death through JNK R-HSA-193648 7.277766e-04 3.138 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 7.316148e-04 3.136 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 8.145104e-04 3.089 1 1
Regulation of TP53 Expression R-HSA-6804754 9.883061e-04 3.005 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.081876e-03 2.966 0 0
HATs acetylate histones R-HSA-3214847 1.081876e-03 2.966 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.346200e-03 2.871 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.435417e-03 2.843 0 0
Signaling by ALK in cancer R-HSA-9700206 1.435417e-03 2.843 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.517036e-03 2.819 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.834567e-03 2.736 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.923685e-03 2.716 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.214216e-03 2.655 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.465889e-03 2.608 0 0
Deubiquitination R-HSA-5688426 2.526728e-03 2.597 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.925081e-03 2.534 0 0
Regulation of beta-cell development R-HSA-186712 2.925081e-03 2.534 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 2.930692e-03 2.533 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 2.930692e-03 2.533 0 0
Nuclear Receptor transcription pathway R-HSA-383280 2.953648e-03 2.530 0 0
DNA strand elongation R-HSA-69190 3.138555e-03 2.503 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.175706e-03 2.498 0 0
M Phase R-HSA-68886 3.486668e-03 2.458 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 3.488983e-03 2.457 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 3.815931e-03 2.418 0 0
Mismatch Repair R-HSA-5358508 3.815931e-03 2.418 0 0
Cellular response to heat stress R-HSA-3371556 3.683400e-03 2.434 1 0
ChREBP activates metabolic gene expression R-HSA-163765 4.381863e-03 2.358 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 4.809399e-03 2.318 0 0
Generic Transcription Pathway R-HSA-212436 5.078666e-03 2.294 1 0
Nuclear Envelope Breakdown R-HSA-2980766 5.254620e-03 2.279 0 0
Cellular responses to stress R-HSA-2262752 5.831590e-03 2.234 1 0
Mitotic Telophase/Cytokinesis R-HSA-68884 6.067393e-03 2.217 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 6.236383e-03 2.205 0 0
Activation of the pre-replicative complex R-HSA-68962 6.236383e-03 2.205 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 6.320198e-03 2.199 1 1
Transcriptional Regulation by VENTX R-HSA-8853884 6.527188e-03 2.185 0 0
Meiosis R-HSA-1500620 6.610121e-03 2.180 1 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 7.213788e-03 2.142 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 7.213788e-03 2.142 0 0
Death Receptor Signaling R-HSA-73887 7.508786e-03 2.124 0 0
Regulation of TP53 Degradation R-HSA-6804757 7.640797e-03 2.117 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 7.673931e-03 2.115 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 7.736394e-03 2.111 0 0
Signaling by LTK R-HSA-9842663 8.181514e-03 2.087 0 0
DNA Double Strand Break Response R-HSA-5693606 8.224299e-03 2.085 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 8.523123e-03 2.069 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 9.781880e-03 2.010 0 0
Mitotic Prometaphase R-HSA-68877 9.189829e-03 2.037 0 0
Membrane Trafficking R-HSA-199991 9.719496e-03 2.012 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 9.981478e-03 2.001 0 0
Unwinding of DNA R-HSA-176974 1.007389e-02 1.997 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.025459e-02 1.989 0 0
Notch-HLH transcription pathway R-HSA-350054 1.166851e-02 1.933 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.155033e-02 1.937 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.211802e-02 1.917 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.211802e-02 1.917 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.233478e-02 1.909 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 1.283915e-02 1.891 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.379701e-02 1.860 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.398439e-02 1.854 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.341057e-02 1.873 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.331797e-02 1.876 0 0
G alpha (12/13) signalling events R-HSA-416482 1.312710e-02 1.882 0 0
Cellular responses to stimuli R-HSA-8953897 1.486254e-02 1.828 1 0
snRNP Assembly R-HSA-191859 1.505448e-02 1.822 0 0
Metabolism of non-coding RNA R-HSA-194441 1.505448e-02 1.822 0 0
Mitotic Anaphase R-HSA-68882 1.571438e-02 1.804 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.710945e-02 1.767 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 1.710945e-02 1.767 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 1.710945e-02 1.767 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.704236e-02 1.768 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.700358e-02 1.769 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.670658e-02 1.777 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.663840e-02 1.779 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.762789e-02 1.754 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.762789e-02 1.754 0 0
p75NTR signals via NF-kB R-HSA-193639 1.762789e-02 1.754 0 0
MAP kinase activation R-HSA-450294 1.880179e-02 1.726 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.762789e-02 1.754 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 1.982728e-02 1.703 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 1.982728e-02 1.703 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.982728e-02 1.703 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.982728e-02 1.703 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.990330e-02 1.701 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.990330e-02 1.701 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.015928e-02 1.696 0 0
Signaling by NOTCH3 R-HSA-9012852 2.039239e-02 1.691 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.296010e-02 1.639 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.309572e-02 1.636 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.321602e-02 1.634 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.321602e-02 1.634 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.324066e-02 1.634 0 0
PTK6 Expression R-HSA-8849473 2.345408e-02 1.630 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.345408e-02 1.630 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.345408e-02 1.630 0 0
S Phase R-HSA-69242 2.361518e-02 1.627 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 2.364999e-02 1.626 0 0
Metalloprotease DUBs R-HSA-5689901 2.364999e-02 1.626 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.379271e-02 1.624 0 0
Signaling by AXIN mutants R-HSA-4839735 2.379271e-02 1.624 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.663781e-02 1.575 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.663781e-02 1.575 0 0
MyD88-independent TLR4 cascade R-HSA-166166 2.522706e-02 1.598 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 2.522706e-02 1.598 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.524815e-02 1.598 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.735836e-02 1.563 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.745716e-02 1.561 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 2.764733e-02 1.558 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 2.795079e-02 1.554 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.869317e-02 1.542 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.876147e-02 1.541 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.876147e-02 1.541 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.876147e-02 1.541 0 0
Fanconi Anemia Pathway R-HSA-6783310 3.002986e-02 1.522 1 1
p75NTR recruits signalling complexes R-HSA-209543 3.018101e-02 1.520 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 3.018101e-02 1.520 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 3.018101e-02 1.520 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 3.271121e-02 1.485 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.271121e-02 1.485 0 0
Meiotic synapsis R-HSA-1221632 3.423783e-02 1.465 1 1
AURKA Activation by TPX2 R-HSA-8854518 3.122648e-02 1.505 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 3.122648e-02 1.505 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.054668e-02 1.515 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.245916e-02 1.489 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.426034e-02 1.465 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.442628e-02 1.463 0 0
Kinesins R-HSA-983189 3.442628e-02 1.463 0 0
Nuclear import of Rev protein R-HSA-180746 3.483824e-02 1.458 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 4.130607e-02 1.384 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.130607e-02 1.384 0 0
ALK mutants bind TKIs R-HSA-9700645 4.130607e-02 1.384 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.755365e-02 1.425 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 3.755365e-02 1.425 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.755365e-02 1.425 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 3.916515e-02 1.407 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 3.916515e-02 1.407 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.952701e-02 1.403 0 0
Signaling by NOTCH1 R-HSA-1980143 4.032162e-02 1.394 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 4.100412e-02 1.387 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 3.755365e-02 1.425 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 3.916515e-02 1.407 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.752705e-02 1.426 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 3.916515e-02 1.407 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 4.024497e-02 1.395 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 4.130607e-02 1.384 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 3.655888e-02 1.437 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.862368e-02 1.413 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.161352e-02 1.381 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 4.214669e-02 1.375 0 0
Interleukin-37 signaling R-HSA-9008059 4.238088e-02 1.373 0 0
Interleukin-17 signaling R-HSA-448424 4.480942e-02 1.349 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 4.483999e-02 1.348 0 0
Neurodegenerative Diseases R-HSA-8863678 4.483999e-02 1.348 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 4.483999e-02 1.348 0 0
Reproduction R-HSA-1474165 4.608429e-02 1.336 1 0
Signaling by EGFR R-HSA-177929 4.610788e-02 1.336 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.637471e-02 1.334 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.534943e-02 1.257 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 5.435575e-02 1.265 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 5.435575e-02 1.265 0 0
Sema4D in semaphorin signaling R-HSA-400685 5.166452e-02 1.287 0 0
TGFBR3 expression R-HSA-9839394 5.166452e-02 1.287 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 5.337469e-02 1.273 0 0
Josephin domain DUBs R-HSA-5689877 5.246108e-02 1.280 0 0
Signaling by WNT in cancer R-HSA-4791275 5.464713e-02 1.262 0 0
Diseases of mitotic cell cycle R-HSA-9675126 5.464713e-02 1.262 0 0
TCF dependent signaling in response to WNT R-HSA-201681 4.878240e-02 1.312 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 5.256061e-02 1.279 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 5.014651e-02 1.300 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 5.534943e-02 1.257 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.560850e-02 1.255 0 0
G2/M Transition R-HSA-69275 5.663333e-02 1.247 0 0
Mitotic Prophase R-HSA-68875 5.696459e-02 1.244 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 5.739808e-02 1.241 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 5.996557e-02 1.222 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 6.050410e-02 1.218 0 0
Extension of Telomeres R-HSA-180786 6.054465e-02 1.218 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 6.154837e-02 1.211 0 0
Cardiogenesis R-HSA-9733709 6.154837e-02 1.211 0 0
Signaling by ALK R-HSA-201556 6.248880e-02 1.204 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 6.248880e-02 1.204 0 0
Lagging Strand Synthesis R-HSA-69186 6.311747e-02 1.200 0 0
Diseases of Cellular Senescence R-HSA-9630747 6.905347e-02 1.161 0 0
Diseases of cellular response to stress R-HSA-9675132 6.905347e-02 1.161 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 6.905347e-02 1.161 0 0
Regulation of cortical dendrite branching R-HSA-8985801 6.905347e-02 1.161 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 7.337194e-02 1.134 0 0
Signaling by APC mutants R-HSA-4839744 6.509000e-02 1.186 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 6.509000e-02 1.186 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 6.509000e-02 1.186 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 6.509000e-02 1.186 0 0
Signaling by PDGFR in disease R-HSA-9671555 7.266249e-02 1.139 0 0
Interaction between L1 and Ankyrins R-HSA-445095 6.717937e-02 1.173 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 6.755126e-02 1.170 0 0
Centrosome maturation R-HSA-380287 6.701165e-02 1.174 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 7.444461e-02 1.128 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 7.544285e-02 1.122 0 0
Epigenetic regulation of gene expression R-HSA-212165 7.366638e-02 1.133 0 0
Aggrephagy R-HSA-9646399 6.932420e-02 1.159 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 6.509000e-02 1.186 0 0
ESR-mediated signaling R-HSA-8939211 6.569384e-02 1.182 0 0
Organelle biogenesis and maintenance R-HSA-1852241 6.619092e-02 1.179 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 7.266249e-02 1.139 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 6.932420e-02 1.159 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 7.660830e-02 1.116 0 0
Apoptotic execution phase R-HSA-75153 6.874413e-02 1.163 0 0
Dual Incision in GG-NER R-HSA-5696400 7.691888e-02 1.114 0 0
NOD1/2 Signaling Pathway R-HSA-168638 7.691888e-02 1.114 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 7.725281e-02 1.112 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 7.764746e-02 1.110 0 0
tRNA processing in the nucleus R-HSA-6784531 7.770229e-02 1.110 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 7.915376e-02 1.102 0 0
Signaling by GSK3beta mutants R-HSA-5339716 7.915376e-02 1.102 0 0
NF-kB is activated and signals survival R-HSA-209560 7.915376e-02 1.102 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 7.915376e-02 1.102 0 0
Signaling by AMER1 mutants R-HSA-4839748 7.915376e-02 1.102 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 7.915376e-02 1.102 0 0
Circadian clock R-HSA-9909396 8.070855e-02 1.093 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.013645e-01 0.994 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.013645e-01 0.994 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.013645e-01 0.994 0 0
Deletions in the AXIN1 gene destabilize the destruction complex R-HSA-5467345 1.013645e-01 0.994 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.013645e-01 0.994 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.013645e-01 0.994 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.013645e-01 0.994 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.013645e-01 0.994 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.013645e-01 0.994 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.013645e-01 0.994 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.013645e-01 0.994 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.013645e-01 0.994 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.007784e-01 0.997 0 0
MET interacts with TNS proteins R-HSA-8875513 1.007784e-01 0.997 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 9.331409e-02 1.030 0 0
Regulation of PTEN localization R-HSA-8948747 9.331409e-02 1.030 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 9.459312e-02 1.024 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 9.459312e-02 1.024 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 9.459312e-02 1.024 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 9.459312e-02 1.024 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 9.459312e-02 1.024 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 9.459312e-02 1.024 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 9.459312e-02 1.024 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 9.516372e-02 1.022 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.104587e-02 1.041 0 0
NGF-stimulated transcription R-HSA-9031628 8.253459e-02 1.083 0 0
DNA Damage Bypass R-HSA-73893 9.002045e-02 1.046 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.520985e-02 1.070 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 9.331409e-02 1.030 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 8.427728e-02 1.074 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 8.713555e-02 1.060 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 9.459312e-02 1.024 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 9.408102e-02 1.026 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 8.520985e-02 1.070 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 9.516372e-02 1.022 0 0
Cilium Assembly R-HSA-5617833 9.813367e-02 1.008 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 1.007784e-01 0.997 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 8.971678e-02 1.047 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.408102e-02 1.026 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.069802e-02 1.042 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.007784e-01 0.997 0 0
Regulation of gene expression in beta cells R-HSA-210745 8.520985e-02 1.070 0 0
MITF-M-dependent gene expression R-HSA-9856651 9.800399e-02 1.009 0 0
PKR-mediated signaling R-HSA-9833482 9.551546e-02 1.020 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.031531e-01 0.987 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.031531e-01 0.987 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.031531e-01 0.987 0 0
Selective autophagy R-HSA-9663891 1.033128e-01 0.986 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.033857e-01 0.986 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.039930e-01 0.983 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.050003e-01 0.979 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.059286e-01 0.975 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 1.059286e-01 0.975 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.059286e-01 0.975 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.087385e-01 0.964 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.113320e-01 0.953 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.144505e-01 0.941 0 0
Adipogenesis R-HSA-9843745 1.152148e-01 0.938 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 1.169492e-01 0.932 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.169492e-01 0.932 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.170382e-01 0.932 0 0
Translesion Synthesis by POLH R-HSA-110320 1.175235e-01 0.930 0 0
The NLRP3 inflammasome R-HSA-844456 1.175235e-01 0.930 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.181308e-01 0.928 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.181308e-01 0.928 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.181308e-01 0.928 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.181308e-01 0.928 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.181308e-01 0.928 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.185085e-01 0.926 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.185085e-01 0.926 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.197577e-01 0.922 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.198178e-01 0.921 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.204527e-01 0.919 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.204527e-01 0.919 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.356388e-01 0.868 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 1.356388e-01 0.868 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.388142e-01 0.858 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 1.638795e-01 0.785 0 0
Removal of the Flap Intermediate R-HSA-69166 1.292804e-01 0.888 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.483380e-01 0.829 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.327818e-01 0.877 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.327818e-01 0.877 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.488753e-01 0.827 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.457545e-01 0.836 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.469885e-01 0.833 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.551022e-01 0.809 0 0
Nucleotide Excision Repair R-HSA-5696398 1.301572e-01 0.886 0 0
Signal attenuation R-HSA-74749 1.638795e-01 0.785 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 1.449620e-01 0.839 0 0
Synthesis of DNA R-HSA-69239 1.440918e-01 0.841 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.551022e-01 0.809 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 1.356388e-01 0.868 0 0
Interleukin-1 processing R-HSA-448706 1.388142e-01 0.858 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 1.388142e-01 0.858 0 0
Signaling by NOTCH R-HSA-157118 1.381793e-01 0.860 0 0
Separation of Sister Chromatids R-HSA-2467813 1.266081e-01 0.898 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.449620e-01 0.839 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.430865e-01 0.844 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 1.286775e-01 0.890 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 1.286775e-01 0.890 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 1.483208e-01 0.829 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.472119e-01 0.832 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 1.483208e-01 0.829 0 0
Calcineurin activates NFAT R-HSA-2025928 1.388142e-01 0.858 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.603545e-01 0.795 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.449953e-01 0.839 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.589450e-01 0.799 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.317941e-01 0.880 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.401586e-01 0.853 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 1.356388e-01 0.868 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 1.356388e-01 0.868 0 0
Macroautophagy R-HSA-1632852 1.311408e-01 0.882 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.286642e-01 0.891 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 1.292804e-01 0.888 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.241263e-01 0.906 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.638795e-01 0.785 0 0
Heme signaling R-HSA-9707616 1.356864e-01 0.867 0 0
Sensory processing of sound R-HSA-9659379 1.463954e-01 0.834 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.235142e-01 0.908 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.638795e-01 0.785 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.297056e-01 0.887 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.644934e-01 0.784 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.644934e-01 0.784 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 1.657453e-01 0.781 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 1.657453e-01 0.781 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.657453e-01 0.781 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.683963e-01 0.774 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.683963e-01 0.774 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.687475e-01 0.773 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 1.726738e-01 0.763 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 1.726738e-01 0.763 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.726738e-01 0.763 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 1.726738e-01 0.763 0 0
G2 Phase R-HSA-68911 1.726738e-01 0.763 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.726738e-01 0.763 0 0
Reelin signalling pathway R-HSA-8866376 1.726738e-01 0.763 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.755556e-01 0.756 0 0
CASP5 inflammasome assembly R-HSA-9948011 1.924597e-01 0.716 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.924597e-01 0.716 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.924597e-01 0.716 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.924597e-01 0.716 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.924597e-01 0.716 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 1.924597e-01 0.716 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.924597e-01 0.716 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 1.924597e-01 0.716 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 1.924597e-01 0.716 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 1.924597e-01 0.716 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.924597e-01 0.716 0 0
Blockage of phagosome acidification R-HSA-9636467 1.924597e-01 0.716 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.743252e-01 0.562 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 2.743252e-01 0.562 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 2.743252e-01 0.562 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 2.743252e-01 0.562 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 2.743252e-01 0.562 0 0
XAV939 stabilizes AXIN R-HSA-5545619 2.743252e-01 0.562 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 2.743252e-01 0.562 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.743252e-01 0.562 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 2.743252e-01 0.562 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 2.743252e-01 0.562 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 2.743252e-01 0.562 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 2.743252e-01 0.562 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.743252e-01 0.562 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 2.743252e-01 0.562 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.743252e-01 0.562 0 0
IKBKB deficiency causes SCID R-HSA-5602636 2.743252e-01 0.562 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 2.743252e-01 0.562 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.743252e-01 0.562 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 2.110851e-01 0.676 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 2.110851e-01 0.676 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 2.110851e-01 0.676 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 2.110851e-01 0.676 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 2.110851e-01 0.676 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.110851e-01 0.676 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.478959e-01 0.459 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 3.478959e-01 0.459 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.478959e-01 0.459 0 0
TGFBR3 regulates activin signaling R-HSA-9839406 3.478959e-01 0.459 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.478959e-01 0.459 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.478959e-01 0.459 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.478959e-01 0.459 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 3.478959e-01 0.459 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.478959e-01 0.459 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.478959e-01 0.459 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.478959e-01 0.459 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.478959e-01 0.459 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.478959e-01 0.459 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.478959e-01 0.459 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.502136e-01 0.602 0 0
CREB phosphorylation R-HSA-199920 2.502136e-01 0.602 0 0
Signaling by LTK in cancer R-HSA-9842640 2.502136e-01 0.602 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.901557e-01 0.721 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 2.173996e-01 0.663 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 2.173996e-01 0.663 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 2.895196e-01 0.538 0 0
SOS-mediated signalling R-HSA-112412 2.895196e-01 0.538 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 2.895196e-01 0.538 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 4.140117e-01 0.383 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 4.140117e-01 0.383 0 0
Axonal growth stimulation R-HSA-209563 4.140117e-01 0.383 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 4.140117e-01 0.383 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.140117e-01 0.383 0 0
Defective ABCC2 causes DJS R-HSA-5679001 4.140117e-01 0.383 0 0
Invadopodia formation R-HSA-8941237 4.140117e-01 0.383 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 4.140117e-01 0.383 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.893418e-01 0.723 0 0
Repression of WNT target genes R-HSA-4641265 2.453786e-01 0.610 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 2.453786e-01 0.610 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 2.453786e-01 0.610 0 0
Polymerase switching R-HSA-69091 2.453786e-01 0.610 0 0
Leading Strand Synthesis R-HSA-69109 2.453786e-01 0.610 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 2.453786e-01 0.610 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.285652e-01 0.483 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.285652e-01 0.483 0 0
Type I hemidesmosome assembly R-HSA-446107 3.285652e-01 0.483 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 3.285652e-01 0.483 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 3.285652e-01 0.483 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 2.738736e-01 0.562 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.913159e-01 0.718 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.913159e-01 0.718 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 3.026811e-01 0.519 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 3.026811e-01 0.519 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.669997e-01 0.435 0 0
WNT mediated activation of DVL R-HSA-201688 3.669997e-01 0.435 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.734276e-01 0.325 0 0
NADE modulates death signalling R-HSA-205025 4.734276e-01 0.325 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.734276e-01 0.325 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.734276e-01 0.325 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.734276e-01 0.325 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 4.734276e-01 0.325 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.734276e-01 0.325 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 4.734276e-01 0.325 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 2.075912e-01 0.683 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 2.396811e-01 0.620 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 2.796583e-01 0.553 0 0
DCC mediated attractive signaling R-HSA-418885 3.316145e-01 0.479 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 3.316145e-01 0.479 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 3.316145e-01 0.479 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 3.316145e-01 0.479 0 0
SHC1 events in EGFR signaling R-HSA-180336 3.316145e-01 0.479 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 3.316145e-01 0.479 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 2.594306e-01 0.586 0 0
2-LTR circle formation R-HSA-164843 4.045458e-01 0.393 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 4.045458e-01 0.393 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.795437e-01 0.554 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.977887e-01 0.704 0 0
Striated Muscle Contraction R-HSA-390522 2.590377e-01 0.587 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 3.605044e-01 0.443 0 0
Translesion synthesis by POLI R-HSA-5656121 3.605044e-01 0.443 0 0
Phosphorylation of the APC/C R-HSA-176412 3.605044e-01 0.443 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.103947e-01 0.677 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.103947e-01 0.677 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.205781e-01 0.494 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 3.510831e-01 0.455 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 3.891993e-01 0.410 0 0
Translesion synthesis by POLK R-HSA-5655862 3.891993e-01 0.410 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.409887e-01 0.356 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 4.409887e-01 0.356 0 0
IRS activation R-HSA-74713 5.268222e-01 0.278 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.268222e-01 0.278 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 2.500011e-01 0.602 0 0
DAP12 signaling R-HSA-2424491 3.413621e-01 0.467 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.750370e-01 0.426 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.750370e-01 0.426 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.587838e-01 0.587 0 0
Dual incision in TC-NER R-HSA-6782135 2.776829e-01 0.556 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.989107e-01 0.399 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 4.761662e-01 0.322 0 0
Activation of RAC1 R-HSA-428540 4.761662e-01 0.322 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 4.761662e-01 0.322 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.206716e-01 0.494 0 0
Signaling by TGFBR3 R-HSA-9839373 3.569430e-01 0.447 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.081709e-01 0.511 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.081709e-01 0.511 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 4.247879e-01 0.372 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 4.247879e-01 0.372 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 4.728524e-01 0.325 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 4.728524e-01 0.325 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 5.099604e-01 0.292 0 0
IRAK1 recruits IKK complex R-HSA-937039 5.099604e-01 0.292 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 5.099604e-01 0.292 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.099604e-01 0.292 0 0
Post-translational protein phosphorylation R-HSA-8957275 3.838615e-01 0.416 0 0
mRNA 3'-end processing R-HSA-72187 4.597698e-01 0.337 0 0
G1/S-Specific Transcription R-HSA-69205 4.860907e-01 0.313 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 5.256133e-01 0.279 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 5.256133e-01 0.279 0 0
Amino acids regulate mTORC1 R-HSA-9639288 4.766754e-01 0.322 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 3.812559e-01 0.419 0 0
HCMV Early Events R-HSA-9609690 4.430144e-01 0.354 0 0
PTEN Regulation R-HSA-6807070 2.366771e-01 0.626 0 0
Signaling by EGFR in Cancer R-HSA-1643713 4.460976e-01 0.351 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 2.102707e-01 0.677 0 0
Protein folding R-HSA-391251 4.089023e-01 0.388 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.228377e-01 0.491 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 3.032958e-01 0.518 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 3.032958e-01 0.518 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 3.256618e-01 0.487 0 0
Signaling by NOTCH2 R-HSA-1980145 2.768978e-01 0.558 0 0
Chromosome Maintenance R-HSA-73886 2.038297e-01 0.691 0 0
Chaperonin-mediated protein folding R-HSA-390466 3.328825e-01 0.478 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 4.280444e-01 0.369 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 4.280444e-01 0.369 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.110577e-01 0.676 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.110577e-01 0.676 0 0
Telomere Maintenance R-HSA-157579 2.707251e-01 0.567 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 4.280444e-01 0.369 0 0
Pexophagy R-HSA-9664873 4.045458e-01 0.393 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 3.605044e-01 0.443 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 2.173996e-01 0.663 0 0
MET activates RAS signaling R-HSA-8851805 2.453786e-01 0.610 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 2.796583e-01 0.553 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.409922e-01 0.618 0 0
G0 and Early G1 R-HSA-1538133 3.831377e-01 0.417 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 3.296525e-01 0.482 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 3.026811e-01 0.519 0 0
p75NTR regulates axonogenesis R-HSA-193697 3.669997e-01 0.435 0 0
Stabilization of p53 R-HSA-69541 3.693222e-01 0.433 0 0
EGFR downregulation R-HSA-182971 3.622362e-01 0.441 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.510831e-01 0.455 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 3.394700e-01 0.469 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 5.060270e-01 0.296 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 3.285652e-01 0.483 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 3.352994e-01 0.475 0 0
Oncogenic MAPK signaling R-HSA-6802957 4.093477e-01 0.388 0 0
G1 Phase R-HSA-69236 3.229036e-01 0.491 0 0
Cyclin D associated events in G1 R-HSA-69231 3.229036e-01 0.491 0 0
Nephron development R-HSA-9831926 4.454829e-01 0.351 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.895196e-01 0.538 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 2.110577e-01 0.676 0 0
Translesion synthesis by REV1 R-HSA-110312 3.316145e-01 0.479 0 0
PI3K/AKT activation R-HSA-198203 4.045458e-01 0.393 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.417743e-01 0.617 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 3.831377e-01 0.417 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 3.740913e-01 0.427 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.673644e-01 0.435 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 4.995866e-01 0.301 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.653296e-01 0.437 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.954903e-01 0.709 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.334266e-01 0.632 0 0
Recycling pathway of L1 R-HSA-437239 3.740913e-01 0.427 0 0
Signaling by ERBB2 R-HSA-1227986 4.411566e-01 0.355 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 4.761662e-01 0.322 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 3.831377e-01 0.417 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 3.133887e-01 0.504 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 3.413621e-01 0.467 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 3.605044e-01 0.443 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.841004e-01 0.735 0 0
FOXO-mediated transcription R-HSA-9614085 5.105574e-01 0.292 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 4.734276e-01 0.325 0 0
Intraflagellar transport R-HSA-5620924 3.912790e-01 0.408 0 0
VLDLR internalisation and degradation R-HSA-8866427 5.099604e-01 0.292 0 0
Orc1 removal from chromatin R-HSA-68949 4.597698e-01 0.337 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 2.246235e-01 0.649 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 1.824545e-01 0.739 0 0
Germ layer formation at gastrulation R-HSA-9754189 4.728524e-01 0.325 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.084724e-01 0.389 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.084724e-01 0.389 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 4.992054e-01 0.302 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 4.992054e-01 0.302 0 0
G1/S Transition R-HSA-69206 3.318378e-01 0.479 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 2.415004e-01 0.617 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.150745e-01 0.667 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.660249e-01 0.575 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.732943e-01 0.428 0 0
Netrin-1 signaling R-HSA-373752 4.810594e-01 0.318 0 0
Signalling to RAS R-HSA-167044 3.032958e-01 0.518 0 0
Meiotic recombination R-HSA-912446 1.855138e-01 0.732 0 0
Signaling by TGFB family members R-HSA-9006936 2.754933e-01 0.560 0 0
Signaling by WNT R-HSA-195721 2.138371e-01 0.670 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 4.839421e-01 0.315 0 0
MTOR signalling R-HSA-165159 4.442156e-01 0.352 0 0
DNA Replication Pre-Initiation R-HSA-69002 3.175160e-01 0.498 0 0
RNA Polymerase III Transcription R-HSA-74158 3.133887e-01 0.504 0 0
Nef mediated downregulation of CD28 cell surface expression R-HSA-164939 2.743252e-01 0.562 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 3.891993e-01 0.410 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.268222e-01 0.278 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.268222e-01 0.278 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.637290e-01 0.579 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 4.175646e-01 0.379 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 2.769230e-01 0.558 0 0
Neddylation R-HSA-8951664 5.074811e-01 0.295 0 0
Intracellular signaling by second messengers R-HSA-9006925 5.018755e-01 0.299 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.750370e-01 0.426 0 0
IGF1R signaling cascade R-HSA-2428924 5.039383e-01 0.298 0 0
Myogenesis R-HSA-525793 2.594306e-01 0.586 0 0
Autophagy R-HSA-9612973 1.792711e-01 0.746 0 0
mTORC1-mediated signalling R-HSA-166208 1.833287e-01 0.737 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.597698e-01 0.337 0 0
Toll-like Receptor Cascades R-HSA-168898 2.515871e-01 0.599 0 0
DNA Replication R-HSA-69306 2.908333e-01 0.536 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.418550e-01 0.616 0 0
Semaphorin interactions R-HSA-373755 2.333969e-01 0.632 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 2.110851e-01 0.676 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 2.895196e-01 0.538 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 3.026811e-01 0.519 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 3.026811e-01 0.519 0 0
Interleukin-1 family signaling R-HSA-446652 3.637092e-01 0.439 0 0
Signaling by NODAL R-HSA-1181150 4.995866e-01 0.301 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 5.193136e-01 0.285 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.415004e-01 0.617 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 5.256133e-01 0.279 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 5.144562e-01 0.289 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 4.255859e-01 0.371 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 3.026811e-01 0.519 0 0
Axon guidance R-HSA-422475 4.395979e-01 0.357 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.893418e-01 0.723 0 0
PERK regulates gene expression R-HSA-381042 2.950313e-01 0.530 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 4.175646e-01 0.379 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.989107e-01 0.399 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.600195e-01 0.585 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 1.833287e-01 0.737 0 0
Nervous system development R-HSA-9675108 4.894086e-01 0.310 0 0
Vesicle-mediated transport R-HSA-5653656 2.924513e-01 0.534 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.950313e-01 0.530 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 2.299682e-01 0.638 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 1.924597e-01 0.716 0 0
SDK interactions R-HSA-373756 1.924597e-01 0.716 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 2.110851e-01 0.676 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.478959e-01 0.459 0 0
C6 deamination of adenosine R-HSA-75102 3.478959e-01 0.459 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 1.901557e-01 0.721 0 0
Bicarbonate transporters R-HSA-425381 1.901557e-01 0.721 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 2.895196e-01 0.538 0 0
The IPAF inflammasome R-HSA-844623 4.140117e-01 0.383 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 2.738736e-01 0.562 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 2.334266e-01 0.632 0 0
Formation of the ureteric bud R-HSA-9830674 2.015589e-01 0.696 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 3.669997e-01 0.435 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 4.734276e-01 0.325 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.045458e-01 0.393 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.891993e-01 0.410 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.268222e-01 0.278 0 0
Signaling by NOTCH4 R-HSA-9013694 3.814120e-01 0.419 0 0
Signaling by Nuclear Receptors R-HSA-9006931 3.930423e-01 0.406 0 0
Signal Transduction R-HSA-162582 2.551874e-01 0.593 0 0
Rab regulation of trafficking R-HSA-9007101 4.296222e-01 0.367 0 0
Host Interactions of HIV factors R-HSA-162909 3.114517e-01 0.507 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 4.627185e-01 0.335 0 0
Neurexins and neuroligins R-HSA-6794361 3.143285e-01 0.503 0 0
Mitochondrial biogenesis R-HSA-1592230 2.434221e-01 0.614 0 0
HDMs demethylate histones R-HSA-3214842 4.226226e-01 0.374 0 0
Signaling by NTRKs R-HSA-166520 1.824545e-01 0.739 0 0
RET signaling R-HSA-8853659 4.860907e-01 0.313 0 0
Ub-specific processing proteases R-HSA-5689880 1.859428e-01 0.731 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 3.669997e-01 0.435 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 4.728524e-01 0.325 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 4.727617e-01 0.325 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 2.999493e-01 0.523 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.319213e-01 0.479 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 3.256618e-01 0.487 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.382561e-01 0.471 0 0
Negative regulation of MET activity R-HSA-6807004 4.995866e-01 0.301 0 0
Formation of paraxial mesoderm R-HSA-9793380 3.206716e-01 0.494 0 0
L1CAM interactions R-HSA-373760 3.197229e-01 0.495 0 0
Signalling to ERKs R-HSA-187687 4.658770e-01 0.332 0 0
HIV Life Cycle R-HSA-162587 5.036179e-01 0.298 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 3.669997e-01 0.435 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 3.510831e-01 0.455 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.268222e-01 0.278 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.884143e-01 0.311 0 0
Signaling by PTK6 R-HSA-8848021 4.884143e-01 0.311 0 0
Signaling by MET R-HSA-6806834 4.659337e-01 0.332 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 2.396811e-01 0.620 0 0
Diseases of programmed cell death R-HSA-9645723 4.628906e-01 0.335 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 3.143285e-01 0.503 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 2.594306e-01 0.586 0 0
Inflammasomes R-HSA-622312 2.999493e-01 0.523 0 0
Interleukin-15 signaling R-HSA-8983432 5.099604e-01 0.292 0 0
Gap junction trafficking R-HSA-190828 4.810594e-01 0.318 0 0
DSCAM interactions R-HSA-376172 3.478959e-01 0.459 0 0
Disorders of Developmental Biology R-HSA-9675151 1.893418e-01 0.723 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.453786e-01 0.610 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.669997e-01 0.435 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 4.734276e-01 0.325 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 3.891993e-01 0.410 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.891993e-01 0.410 0 0
Synthesis of PI R-HSA-1483226 4.409887e-01 0.356 0 0
Viral Messenger RNA Synthesis R-HSA-168325 3.206716e-01 0.494 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 4.692678e-01 0.329 0 0
Protein-protein interactions at synapses R-HSA-6794362 4.093477e-01 0.388 0 0
Insulin receptor recycling R-HSA-77387 4.920721e-01 0.308 0 0
Base Excision Repair R-HSA-73884 3.706451e-01 0.431 0 0
Interleukin-2 family signaling R-HSA-451927 3.880986e-01 0.411 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 2.984201e-01 0.525 0 0
Specification of primordial germ cells R-HSA-9827857 2.110577e-01 0.676 0 0
PI Metabolism R-HSA-1483255 2.343489e-01 0.630 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.415004e-01 0.617 0 0
MHC class II antigen presentation R-HSA-2132295 3.951143e-01 0.403 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.992054e-01 0.302 0 0
Pyroptosis R-HSA-5620971 2.999493e-01 0.523 0 0
FLT3 signaling in disease R-HSA-9682385 3.133887e-01 0.504 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.502136e-01 0.602 0 0
Tie2 Signaling R-HSA-210993 4.454829e-01 0.351 0 0
Maturation of nucleoprotein R-HSA-9694631 4.728524e-01 0.325 0 0
Rap1 signalling R-HSA-392517 4.728524e-01 0.325 0 0
HSF1 activation R-HSA-3371511 4.860907e-01 0.313 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 5.144562e-01 0.289 0 0
Inositol phosphate metabolism R-HSA-1483249 3.505670e-01 0.455 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.918074e-01 0.535 0 0
Transferrin endocytosis and recycling R-HSA-917977 4.658770e-01 0.332 0 0
RMTs methylate histone arginines R-HSA-3214858 4.810594e-01 0.318 0 0
FLT3 Signaling R-HSA-9607240 4.068671e-01 0.391 0 0
The AIM2 inflammasome R-HSA-844615 3.478959e-01 0.459 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 3.669997e-01 0.435 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.734276e-01 0.325 0 0
Dopamine receptors R-HSA-390651 4.734276e-01 0.325 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.973721e-01 0.705 0 0
NrCAM interactions R-HSA-447038 5.268222e-01 0.278 0 0
Interferon alpha/beta signaling R-HSA-909733 4.068883e-01 0.391 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 3.143285e-01 0.503 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 5.256133e-01 0.279 0 0
Interferon Signaling R-HSA-913531 2.980309e-01 0.526 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 3.510831e-01 0.455 0 0
Interleukin-7 signaling R-HSA-1266695 4.226226e-01 0.374 0 0
RUNX2 regulates bone development R-HSA-8941326 4.860907e-01 0.313 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.669997e-01 0.435 0 0
Integration of provirus R-HSA-162592 4.761662e-01 0.322 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.692678e-01 0.329 0 0
TNF signaling R-HSA-75893 3.774080e-01 0.423 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 4.409887e-01 0.356 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 5.256481e-01 0.279 0 0
Gap junction assembly R-HSA-190861 4.454276e-01 0.351 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.730269e-01 0.564 0 0
Nephrin family interactions R-HSA-373753 4.995866e-01 0.301 0 0
Vasopressin-like receptors R-HSA-388479 4.734276e-01 0.325 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 5.268222e-01 0.278 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 4.454276e-01 0.351 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.204709e-01 0.494 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.500011e-01 0.602 0 0
IRE1alpha activates chaperones R-HSA-381070 3.961183e-01 0.402 0 0
Interleukin-2 signaling R-HSA-9020558 4.409887e-01 0.356 0 0
Early Phase of HIV Life Cycle R-HSA-162594 5.256133e-01 0.279 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 4.454276e-01 0.351 0 0
Interleukin-1 signaling R-HSA-9020702 5.353492e-01 0.271 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 5.363723e-01 0.271 0 0
Activation of BH3-only proteins R-HSA-114452 5.363723e-01 0.271 0 0
UCH proteinases R-HSA-5689603 5.417113e-01 0.266 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 5.422901e-01 0.266 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 5.422901e-01 0.266 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.422901e-01 0.266 0 0
Maturation of nucleoprotein R-HSA-9683610 5.422901e-01 0.266 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 5.422901e-01 0.266 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.422901e-01 0.266 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 5.473737e-01 0.262 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 5.482187e-01 0.261 0 0
Kidney development R-HSA-9830369 5.495432e-01 0.260 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 5.508730e-01 0.259 0 0
Mitochondrial calcium ion transport R-HSA-8949215 5.508730e-01 0.259 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 5.508730e-01 0.259 0 0
GPER1 signaling R-HSA-9634597 5.521798e-01 0.258 0 0
Apoptosis R-HSA-109581 5.526303e-01 0.258 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 5.557800e-01 0.255 0 0
Downstream signal transduction R-HSA-186763 5.577790e-01 0.254 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 5.577790e-01 0.254 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.577790e-01 0.254 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 5.585818e-01 0.253 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 5.638120e-01 0.249 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 5.638120e-01 0.249 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 5.667762e-01 0.247 0 0
Gap junction trafficking and regulation R-HSA-157858 5.692639e-01 0.245 0 0
Response of endothelial cells to shear stress R-HSA-9860931 5.717155e-01 0.243 0 0
Non-canonical inflammasome activation R-HSA-9686114 5.731049e-01 0.242 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.731049e-01 0.242 0 0
Regulation of KIT signaling R-HSA-1433559 5.731049e-01 0.242 0 0
Signaling by FGFR4 in disease R-HSA-5655291 5.731049e-01 0.242 0 0
Physiological factors R-HSA-5578768 5.731049e-01 0.242 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 5.748054e-01 0.240 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.748054e-01 0.240 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.748054e-01 0.240 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.748054e-01 0.240 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 5.748054e-01 0.240 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 5.748054e-01 0.240 0 0
Signaling by RNF43 mutants R-HSA-5340588 5.748054e-01 0.240 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.748054e-01 0.240 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 5.748054e-01 0.240 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 5.748054e-01 0.240 0 0
NGF-independant TRKA activation R-HSA-187024 5.748054e-01 0.240 0 0
Ceramide signalling R-HSA-193681 5.748054e-01 0.240 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 5.748054e-01 0.240 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.748054e-01 0.240 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 5.748054e-01 0.240 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 5.753183e-01 0.240 0 0
Signaling by KIT in disease R-HSA-9669938 5.753183e-01 0.240 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 5.753183e-01 0.240 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 5.760230e-01 0.240 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 5.760230e-01 0.240 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 5.791424e-01 0.237 0 0
Cellular response to chemical stress R-HSA-9711123 5.811473e-01 0.236 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 5.822974e-01 0.235 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 5.835812e-01 0.234 0 0
Activation of HOX genes during differentiation R-HSA-5619507 5.835812e-01 0.234 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 5.877205e-01 0.231 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 5.897180e-01 0.229 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 5.915091e-01 0.228 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 5.931054e-01 0.227 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.933373e-01 0.227 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 5.989129e-01 0.223 0 0
Integrin signaling R-HSA-354192 5.989287e-01 0.223 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 5.989287e-01 0.223 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 5.989287e-01 0.223 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 5.989463e-01 0.223 0 0
Degradation of CRY and PER proteins R-HSA-9932298 6.003528e-01 0.222 0 0
Intra-Golgi traffic R-HSA-6811438 6.003528e-01 0.222 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 6.023796e-01 0.220 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 6.023796e-01 0.220 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 6.023796e-01 0.220 0 0
G beta:gamma signalling through BTK R-HSA-8964315 6.023796e-01 0.220 0 0
Erythropoietin activates RAS R-HSA-9027284 6.023796e-01 0.220 0 0
Signaling by Activin R-HSA-1502540 6.023796e-01 0.220 0 0
FASTK family proteins regulate processing and stability of mitochondrial RNAs R-HSA-9837092 6.023796e-01 0.220 0 0
Cell-extracellular matrix interactions R-HSA-446353 6.023796e-01 0.220 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.023796e-01 0.220 0 0
Biotin transport and metabolism R-HSA-196780 6.023796e-01 0.220 0 0
Protein methylation R-HSA-8876725 6.023796e-01 0.220 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 6.023796e-01 0.220 0 0
Programmed Cell Death R-HSA-5357801 6.130488e-01 0.213 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.179254e-01 0.209 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.179254e-01 0.209 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 6.179254e-01 0.209 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.179254e-01 0.209 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.179254e-01 0.209 0 0
Neurofascin interactions R-HSA-447043 6.179254e-01 0.209 0 0
Lactose synthesis R-HSA-5653890 6.179254e-01 0.209 0 0
HDL clearance R-HSA-8964011 6.179254e-01 0.209 0 0
Nef and signal transduction R-HSA-164944 6.179254e-01 0.209 0 0
CREB3 factors activate genes R-HSA-8874211 6.179254e-01 0.209 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 6.179580e-01 0.209 0 0
Gene Silencing by RNA R-HSA-211000 6.182937e-01 0.209 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 6.186177e-01 0.209 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 6.197151e-01 0.208 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 6.197151e-01 0.208 0 0
Deadenylation of mRNA R-HSA-429947 6.216301e-01 0.206 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 6.216301e-01 0.206 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 6.216301e-01 0.206 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 6.216301e-01 0.206 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.301096e-01 0.201 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 6.301096e-01 0.201 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 6.301096e-01 0.201 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 6.301096e-01 0.201 0 0
Killing mechanisms R-HSA-9664420 6.301096e-01 0.201 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.301096e-01 0.201 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.301096e-01 0.201 0 0
Phase 4 - resting membrane potential R-HSA-5576886 6.301096e-01 0.201 0 0
Activation of the phototransduction cascade R-HSA-2485179 6.301096e-01 0.201 0 0
Regulation of BACH1 activity R-HSA-9708530 6.301096e-01 0.201 0 0
Differentiation of T cells R-HSA-9945266 6.301096e-01 0.201 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 6.301096e-01 0.201 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.301096e-01 0.201 0 0
Smooth Muscle Contraction R-HSA-445355 6.341824e-01 0.198 0 0
HIV Infection R-HSA-162906 6.347865e-01 0.197 0 0
Signaling by SCF-KIT R-HSA-1433557 6.350961e-01 0.197 0 0
TBC/RABGAPs R-HSA-8854214 6.350961e-01 0.197 0 0
Signaling by FGFR4 R-HSA-5654743 6.350961e-01 0.197 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 6.376890e-01 0.195 0 0
Late Phase of HIV Life Cycle R-HSA-162599 6.384871e-01 0.195 0 0
Acyl chain remodelling of PS R-HSA-1482801 6.434522e-01 0.191 0 0
Signaling by FGFR in disease R-HSA-1226099 6.482680e-01 0.188 0 0
Signaling by Insulin receptor R-HSA-74752 6.493388e-01 0.188 0 0
DAP12 interactions R-HSA-2172127 6.517534e-01 0.186 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 6.538451e-01 0.185 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 6.561281e-01 0.183 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 6.561281e-01 0.183 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 6.563071e-01 0.183 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 6.563071e-01 0.183 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 6.563071e-01 0.183 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 6.563071e-01 0.183 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.566747e-01 0.183 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 6.566747e-01 0.183 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 6.566747e-01 0.183 0 0
Netrin mediated repulsion signals R-HSA-418886 6.566747e-01 0.183 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.566747e-01 0.183 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.566747e-01 0.183 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.566747e-01 0.183 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 6.566747e-01 0.183 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.566747e-01 0.183 0 0
Opsins R-HSA-419771 6.566747e-01 0.183 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.566747e-01 0.183 0 0
Activation of TRKA receptors R-HSA-187015 6.566747e-01 0.183 0 0
CHL1 interactions R-HSA-447041 6.566747e-01 0.183 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.566747e-01 0.183 0 0
Assembly of the pre-replicative complex R-HSA-68867 6.610634e-01 0.180 0 0
Protein ubiquitination R-HSA-8852135 6.613123e-01 0.180 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 6.643693e-01 0.178 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 6.643693e-01 0.178 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 6.643693e-01 0.178 0 0
HDACs deacetylate histones R-HSA-3214815 6.643809e-01 0.178 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 6.679187e-01 0.175 0 0
Nucleosome assembly R-HSA-774815 6.679187e-01 0.175 0 0
Signaling by FGFR3 R-HSA-5654741 6.679187e-01 0.175 0 0
Signaling by FGFR1 R-HSA-5654736 6.788770e-01 0.168 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 6.788770e-01 0.168 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.809977e-01 0.167 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 6.809977e-01 0.167 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 6.809977e-01 0.167 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 6.809977e-01 0.167 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.809977e-01 0.167 0 0
Uptake and function of anthrax toxins R-HSA-5210891 6.809977e-01 0.167 0 0
Signaling by Hippo R-HSA-2028269 6.809977e-01 0.167 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 6.835837e-01 0.165 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 6.835837e-01 0.165 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 6.843782e-01 0.165 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 6.843782e-01 0.165 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 6.843782e-01 0.165 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 6.843782e-01 0.165 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 6.843782e-01 0.165 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 6.843782e-01 0.165 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 6.897607e-01 0.161 0 0
Degradation of AXIN R-HSA-4641257 6.910725e-01 0.160 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 6.914962e-01 0.160 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.914962e-01 0.160 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.914962e-01 0.160 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.914962e-01 0.160 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 6.914962e-01 0.160 0 0
Formation of annular gap junctions R-HSA-196025 6.914962e-01 0.160 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 6.914962e-01 0.160 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 6.914962e-01 0.160 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 6.914962e-01 0.160 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 6.914962e-01 0.160 0 0
Sodium/Proton exchangers R-HSA-425986 6.914962e-01 0.160 0 0
FGFR1b ligand binding and activation R-HSA-190370 6.914962e-01 0.160 0 0
Co-stimulation by ICOS R-HSA-9927354 6.914962e-01 0.160 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 6.914962e-01 0.160 0 0
Alpha-defensins R-HSA-1462054 6.914962e-01 0.160 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 6.914962e-01 0.160 0 0
Regulation of CDH1 Function R-HSA-9764561 6.929616e-01 0.159 0 0
RSV-host interactions R-HSA-9833110 6.938622e-01 0.159 0 0
PCP/CE pathway R-HSA-4086400 6.986737e-01 0.156 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 6.987426e-01 0.156 0 0
Gastrulation R-HSA-9758941 7.024532e-01 0.153 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 7.026581e-01 0.153 0 0
HIV elongation arrest and recovery R-HSA-167287 7.034822e-01 0.153 0 0
Pausing and recovery of HIV elongation R-HSA-167290 7.034822e-01 0.153 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 7.034822e-01 0.153 0 0
Telomere Extension By Telomerase R-HSA-171319 7.034822e-01 0.153 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 7.034822e-01 0.153 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.034822e-01 0.153 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 7.042176e-01 0.152 0 0
GAB1 signalosome R-HSA-180292 7.042176e-01 0.152 0 0
PKA activation R-HSA-163615 7.042176e-01 0.152 0 0
Presynaptic function of Kainate receptors R-HSA-500657 7.042176e-01 0.152 0 0
Platelet sensitization by LDL R-HSA-432142 7.042176e-01 0.152 0 0
Polo-like kinase mediated events R-HSA-156711 7.042176e-01 0.152 0 0
Apoptotic factor-mediated response R-HSA-111471 7.042176e-01 0.152 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 7.042176e-01 0.152 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.042176e-01 0.152 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 7.130037e-01 0.147 0 0
Co-stimulation by CD28 R-HSA-389356 7.133920e-01 0.147 0 0
SARS-CoV-1-host interactions R-HSA-9692914 7.143393e-01 0.146 0 0
tRNA processing R-HSA-72306 7.192717e-01 0.143 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 7.198787e-01 0.143 0 0
Late endosomal microautophagy R-HSA-9615710 7.216895e-01 0.142 0 0
DARPP-32 events R-HSA-180024 7.216895e-01 0.142 0 0
Signaling by Erythropoietin R-HSA-9006335 7.216895e-01 0.142 0 0
Glucagon-type ligand receptors R-HSA-420092 7.216895e-01 0.142 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.227878e-01 0.141 0 0
ARMS-mediated activation R-HSA-170984 7.227878e-01 0.141 0 0
Lipophagy R-HSA-9613354 7.227878e-01 0.141 0 0
Interleukin-21 signaling R-HSA-9020958 7.227878e-01 0.141 0 0
Gap junction degradation R-HSA-190873 7.227878e-01 0.141 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.227878e-01 0.141 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.227878e-01 0.141 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.227878e-01 0.141 0 0
mRNA Editing R-HSA-75072 7.227878e-01 0.141 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.227878e-01 0.141 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.227878e-01 0.141 0 0
Cellular response to mitochondrial stress R-HSA-9840373 7.227878e-01 0.141 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 7.260110e-01 0.139 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 7.260110e-01 0.139 0 0
E2F mediated regulation of DNA replication R-HSA-113510 7.260110e-01 0.139 0 0
COPII-mediated vesicle transport R-HSA-204005 7.265785e-01 0.139 0 0
Degradation of CDH1 R-HSA-9766229 7.275304e-01 0.138 0 0
SARS-CoV-2 Infection R-HSA-9694516 7.319652e-01 0.136 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 7.327061e-01 0.135 0 0
Attenuation phase R-HSA-3371568 7.386131e-01 0.132 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 7.386131e-01 0.132 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.386131e-01 0.132 0 0
Diseases of Immune System R-HSA-5260271 7.386131e-01 0.132 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 7.390129e-01 0.131 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 7.390129e-01 0.131 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 7.391697e-01 0.131 0 0
Signaling by ROBO receptors R-HSA-376176 7.415778e-01 0.130 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 7.451120e-01 0.128 0 0
Co-inhibition by CTLA4 R-HSA-389513 7.464283e-01 0.127 0 0
Formation of definitive endoderm R-HSA-9823730 7.464283e-01 0.127 0 0
CASP4 inflammasome assembly R-HSA-9948001 7.509072e-01 0.124 0 0
Folding of actin by CCT/TriC R-HSA-390450 7.509072e-01 0.124 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 7.509072e-01 0.124 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.509072e-01 0.124 0 0
Formation of intermediate mesoderm R-HSA-9761174 7.509072e-01 0.124 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 7.509072e-01 0.124 0 0
Maturation of spike protein R-HSA-9683686 7.509072e-01 0.124 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 7.509072e-01 0.124 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.509072e-01 0.124 0 0
Tandem pore domain potassium channels R-HSA-1296346 7.509072e-01 0.124 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 7.509072e-01 0.124 0 0
Signaling by Leptin R-HSA-2586552 7.509072e-01 0.124 0 0
Formation of apoptosome R-HSA-111458 7.509072e-01 0.124 0 0
Regulation of CDH11 function R-HSA-9762292 7.509072e-01 0.124 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.542789e-01 0.122 0 0
HSF1-dependent transactivation R-HSA-3371571 7.542789e-01 0.122 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.547904e-01 0.122 0 0
Trafficking of AMPA receptors R-HSA-399719 7.554690e-01 0.122 0 0
SARS-CoV-1 Infection R-HSA-9678108 7.570703e-01 0.121 0 0
NCAM signaling for neurite out-growth R-HSA-375165 7.570972e-01 0.121 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.586952e-01 0.120 0 0
Regulation of endogenous retroelements R-HSA-9842860 7.651828e-01 0.116 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.655245e-01 0.116 0 0
G-protein activation R-HSA-202040 7.655245e-01 0.116 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 7.655245e-01 0.116 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.655245e-01 0.116 0 0
ERK/MAPK targets R-HSA-198753 7.655245e-01 0.116 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 7.670951e-01 0.115 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.761757e-01 0.110 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 7.761757e-01 0.110 0 0
vRNA Synthesis R-HSA-192814 7.761757e-01 0.110 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 7.761757e-01 0.110 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.761757e-01 0.110 0 0
Chylomicron assembly R-HSA-8963888 7.761757e-01 0.110 0 0
Vitamin B1 (thiamin) metabolism R-HSA-196819 7.761757e-01 0.110 0 0
PECAM1 interactions R-HSA-210990 7.761757e-01 0.110 0 0
Prostanoid ligand receptors R-HSA-391908 7.761757e-01 0.110 0 0
Cell junction organization R-HSA-446728 7.783606e-01 0.109 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 7.790138e-01 0.108 0 0
Insulin receptor signalling cascade R-HSA-74751 7.798159e-01 0.108 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 7.803975e-01 0.108 0 0
Adherens junctions interactions R-HSA-418990 7.806089e-01 0.108 0 0
Interferon gamma signaling R-HSA-877300 7.811786e-01 0.107 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 7.833574e-01 0.106 0 0
Nuclear RNA decay R-HSA-9930044 7.858616e-01 0.105 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 7.858616e-01 0.105 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 7.858616e-01 0.105 0 0
Co-inhibition by PD-1 R-HSA-389948 7.886726e-01 0.103 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 7.906408e-01 0.102 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 7.988822e-01 0.098 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 7.988822e-01 0.098 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 7.988822e-01 0.098 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 7.988822e-01 0.098 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 7.988822e-01 0.098 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 7.988822e-01 0.098 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 7.998452e-01 0.097 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 7.998452e-01 0.097 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 7.998452e-01 0.097 0 0
Acyl chain remodelling of PC R-HSA-1482788 7.998452e-01 0.097 0 0
LDL clearance R-HSA-8964038 7.999868e-01 0.097 0 0
Cellular hexose transport R-HSA-189200 7.999868e-01 0.097 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.999868e-01 0.097 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 8.024223e-01 0.096 0 0
Post NMDA receptor activation events R-HSA-438064 8.030985e-01 0.095 0 0
Proteasome assembly R-HSA-9907900 8.051856e-01 0.094 0 0
Muscle contraction R-HSA-397014 8.055195e-01 0.094 0 0
Post-translational protein modification R-HSA-597592 8.075369e-01 0.093 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 8.130548e-01 0.090 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 8.130548e-01 0.090 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.130548e-01 0.090 0 0
Signal amplification R-HSA-392518 8.130548e-01 0.090 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.130548e-01 0.090 0 0
Mitophagy R-HSA-5205647 8.130548e-01 0.090 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 8.130548e-01 0.090 0 0
Termination of O-glycan biosynthesis R-HSA-977068 8.154732e-01 0.089 0 0
Mitochondrial mRNA modification R-HSA-9937008 8.154732e-01 0.089 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 8.154732e-01 0.089 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 8.154732e-01 0.089 0 0
Growth hormone receptor signaling R-HSA-982772 8.154732e-01 0.089 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 8.166999e-01 0.088 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 8.166999e-01 0.088 0 0
DAG and IP3 signaling R-HSA-1489509 8.166999e-01 0.088 0 0
Cell-Cell communication R-HSA-1500931 8.181930e-01 0.087 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.192864e-01 0.087 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 8.192864e-01 0.087 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.192864e-01 0.087 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.192864e-01 0.087 0 0
Proline catabolism R-HSA-70688 8.192864e-01 0.087 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.192864e-01 0.087 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 8.192864e-01 0.087 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.192864e-01 0.087 0 0
Regulation of IFNG signaling R-HSA-877312 8.192864e-01 0.087 0 0
Pervasive developmental disorders R-HSA-9005895 8.192864e-01 0.087 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 8.192864e-01 0.087 0 0
Disorders of Nervous System Development R-HSA-9697154 8.192864e-01 0.087 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.192864e-01 0.087 0 0
IRS-mediated signalling R-HSA-112399 8.226594e-01 0.085 0 0
PPARA activates gene expression R-HSA-1989781 8.236462e-01 0.084 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.255178e-01 0.083 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 8.276486e-01 0.082 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.276486e-01 0.082 0 0
Regulation of TNFR1 signaling R-HSA-5357905 8.276486e-01 0.082 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 8.283971e-01 0.082 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 8.283971e-01 0.082 0 0
Downstream TCR signaling R-HSA-202424 8.284266e-01 0.082 0 0
Thromboxane signalling through TP receptor R-HSA-428930 8.298773e-01 0.081 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 8.298773e-01 0.081 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.298773e-01 0.081 0 0
Mitochondrial RNA degradation R-HSA-9836573 8.298773e-01 0.081 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 8.298773e-01 0.081 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.303813e-01 0.081 0 0
Integration of energy metabolism R-HSA-163685 8.303813e-01 0.081 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.358216e-01 0.078 0 0
Hedgehog 'off' state R-HSA-5610787 8.367088e-01 0.077 0 0
Glycolysis R-HSA-70171 8.367088e-01 0.077 0 0
PRC2 methylates histones and DNA R-HSA-212300 8.372629e-01 0.077 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.372629e-01 0.077 0 0
Calmodulin induced events R-HSA-111933 8.372629e-01 0.077 0 0
CaM pathway R-HSA-111997 8.372629e-01 0.077 0 0
GPVI-mediated activation cascade R-HSA-114604 8.372629e-01 0.077 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.376216e-01 0.077 0 0
OGDH complex synthesizes succinyl-CoA from 2-OG R-HSA-9853506 8.376216e-01 0.077 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.376216e-01 0.077 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.376216e-01 0.077 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 8.376216e-01 0.077 0 0
Chylomicron remodeling R-HSA-8963901 8.376216e-01 0.077 0 0
Processing of SMDT1 R-HSA-8949664 8.376216e-01 0.077 0 0
Formation of axial mesoderm R-HSA-9796292 8.376216e-01 0.077 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.376216e-01 0.077 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 8.376216e-01 0.077 0 0
rRNA modification in the mitochondrion R-HSA-6793080 8.376216e-01 0.077 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.376216e-01 0.077 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 8.380485e-01 0.077 0 0
Signaling by Hedgehog R-HSA-5358351 8.429284e-01 0.074 0 0
HCMV Infection R-HSA-9609646 8.431087e-01 0.074 0 0
G protein gated Potassium channels R-HSA-1296059 8.432594e-01 0.074 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 8.432594e-01 0.074 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 8.432594e-01 0.074 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 8.432594e-01 0.074 0 0
Cytokine Signaling in Immune system R-HSA-1280215 8.434064e-01 0.074 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 8.446662e-01 0.073 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 8.467219e-01 0.072 0 0
Regulation of mitotic cell cycle R-HSA-453276 8.467219e-01 0.072 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 8.467219e-01 0.072 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 8.467219e-01 0.072 0 0
Cell-cell junction organization R-HSA-421270 8.477329e-01 0.072 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.483190e-01 0.071 0 0
Degradation of DVL R-HSA-4641258 8.483190e-01 0.071 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 8.483190e-01 0.071 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 8.508571e-01 0.070 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.540975e-01 0.068 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.540975e-01 0.068 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.540975e-01 0.068 0 0
NRIF signals cell death from the nucleus R-HSA-205043 8.540975e-01 0.068 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 8.540975e-01 0.068 0 0
Prolactin receptor signaling R-HSA-1170546 8.540975e-01 0.068 0 0
Glycerophospholipid catabolism R-HSA-6814848 8.540975e-01 0.068 0 0
Zinc transporters R-HSA-435354 8.540975e-01 0.068 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.540975e-01 0.068 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 8.547737e-01 0.068 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 8.547737e-01 0.068 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.556784e-01 0.068 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.556784e-01 0.068 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 8.572725e-01 0.067 0 0
MET promotes cell motility R-HSA-8875878 8.587154e-01 0.066 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.590627e-01 0.066 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 8.596738e-01 0.066 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.602021e-01 0.065 0 0
Ca2+ pathway R-HSA-4086398 8.624749e-01 0.064 0 0
Opioid Signalling R-HSA-111885 8.640157e-01 0.063 0 0
Regulation of RAS by GAPs R-HSA-5658442 8.661327e-01 0.062 0 0
PI3K Cascade R-HSA-109704 8.661327e-01 0.062 0 0
Signaling by PDGF R-HSA-186797 8.671196e-01 0.062 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.671196e-01 0.062 0 0
Cristae formation R-HSA-8949613 8.671919e-01 0.062 0 0
Packaging Of Telomere Ends R-HSA-171306 8.671919e-01 0.062 0 0
Signaling by BMP R-HSA-201451 8.671919e-01 0.062 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.671919e-01 0.062 0 0
Insulin processing R-HSA-264876 8.671919e-01 0.062 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 8.684816e-01 0.061 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.684816e-01 0.061 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 8.684816e-01 0.061 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.684816e-01 0.061 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.689025e-01 0.061 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.689025e-01 0.061 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.689025e-01 0.061 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.689025e-01 0.061 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 8.689025e-01 0.061 0 0
p38MAPK events R-HSA-171007 8.689025e-01 0.061 0 0
DNA Damage Reversal R-HSA-73942 8.689025e-01 0.061 0 0
Other semaphorin interactions R-HSA-416700 8.689025e-01 0.061 0 0
Spry regulation of FGF signaling R-HSA-1295596 8.689025e-01 0.061 0 0
Formation of the anterior neural plate R-HSA-9823739 8.689025e-01 0.061 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 8.693407e-01 0.061 0 0
Signaling by ERBB4 R-HSA-1236394 8.698349e-01 0.061 0 0
Hedgehog ligand biogenesis R-HSA-5358346 8.745165e-01 0.058 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.768636e-01 0.057 0 0
Iron uptake and transport R-HSA-917937 8.768636e-01 0.057 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 8.776469e-01 0.057 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 8.776469e-01 0.057 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 8.776469e-01 0.057 0 0
HIV Transcription Elongation R-HSA-167169 8.776469e-01 0.057 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.778559e-01 0.057 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 8.810976e-01 0.055 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.822061e-01 0.054 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 8.822061e-01 0.054 0 0
Prolonged ERK activation events R-HSA-169893 8.822061e-01 0.054 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.822061e-01 0.054 0 0
Activation of SMO R-HSA-5635838 8.822061e-01 0.054 0 0
Attachment and Entry R-HSA-9678110 8.822061e-01 0.054 0 0
Atorvastatin ADME R-HSA-9754706 8.822061e-01 0.054 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 8.824423e-01 0.054 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 8.824423e-01 0.054 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 8.835708e-01 0.054 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 8.862402e-01 0.052 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.862402e-01 0.052 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.862402e-01 0.052 0 0
DNA methylation R-HSA-5334118 8.877241e-01 0.052 0 0
Cellular response to hypoxia R-HSA-1234174 8.889910e-01 0.051 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.899289e-01 0.051 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.899289e-01 0.051 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 8.928433e-01 0.049 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 8.941602e-01 0.049 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 8.941602e-01 0.049 0 0
Phase 2 - plateau phase R-HSA-5576893 8.941602e-01 0.049 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 8.941602e-01 0.049 0 0
Glycine degradation R-HSA-6783984 8.941602e-01 0.049 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.941602e-01 0.049 0 0
Signaling by RAF1 mutants R-HSA-9656223 8.942901e-01 0.049 0 0
MAP2K and MAPK activation R-HSA-5674135 8.942901e-01 0.049 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 8.942901e-01 0.049 0 0
Negative regulation of MAPK pathway R-HSA-5675221 8.942901e-01 0.049 0 0
Translation of Structural Proteins R-HSA-9683701 8.942901e-01 0.049 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.952899e-01 0.048 0 0
Cellular response to starvation R-HSA-9711097 8.954685e-01 0.048 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 8.955591e-01 0.048 0 0
RNA Polymerase I Transcription R-HSA-73864 8.960614e-01 0.048 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.968481e-01 0.047 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 8.969947e-01 0.047 0 0
Activation of GABAB receptors R-HSA-991365 9.018243e-01 0.045 0 0
GABA B receptor activation R-HSA-977444 9.018243e-01 0.045 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.018243e-01 0.045 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.018243e-01 0.045 0 0
Ca-dependent events R-HSA-111996 9.018243e-01 0.045 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.018243e-01 0.045 0 0
Depyrimidination R-HSA-73928 9.018243e-01 0.045 0 0
TCR signaling R-HSA-202403 9.028595e-01 0.044 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.036581e-01 0.044 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.049019e-01 0.043 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.052774e-01 0.043 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.052774e-01 0.043 0 0
SARS-CoV Infections R-HSA-9679506 9.068781e-01 0.042 0 0
Signaling by FGFR2 R-HSA-5654738 9.073878e-01 0.042 0 0
Transcription of the HIV genome R-HSA-167172 9.076915e-01 0.042 0 0
Regulated Necrosis R-HSA-5218859 9.076915e-01 0.042 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 9.099370e-01 0.041 0 0
mRNA Splicing - Major Pathway R-HSA-72163 9.120230e-01 0.040 0 0
mRNA Splicing R-HSA-72172 9.125223e-01 0.040 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.130589e-01 0.040 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.130589e-01 0.040 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.145540e-01 0.039 0 0
PKA activation in glucagon signalling R-HSA-164378 9.145540e-01 0.039 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 9.145540e-01 0.039 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.145540e-01 0.039 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.145540e-01 0.039 0 0
Synaptic adhesion-like molecules R-HSA-8849932 9.145540e-01 0.039 0 0
Surfactant metabolism R-HSA-5683826 9.154542e-01 0.038 0 0
EPH-Ephrin signaling R-HSA-2682334 9.179009e-01 0.037 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.185727e-01 0.037 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 9.185727e-01 0.037 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.202372e-01 0.036 0 0
G-protein beta:gamma signalling R-HSA-397795 9.202372e-01 0.036 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 9.202372e-01 0.036 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.214123e-01 0.036 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.216019e-01 0.035 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.216019e-01 0.035 0 0
Somitogenesis R-HSA-9824272 9.216019e-01 0.035 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.216019e-01 0.035 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.232269e-01 0.035 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 9.232269e-01 0.035 0 0
Regulation of signaling by CBL R-HSA-912631 9.232269e-01 0.035 0 0
Specification of the neural plate border R-HSA-9834899 9.232269e-01 0.035 0 0
Other interleukin signaling R-HSA-449836 9.232269e-01 0.035 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.232269e-01 0.035 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.232269e-01 0.035 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 9.232269e-01 0.035 0 0
HDL remodeling R-HSA-8964058 9.232269e-01 0.035 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.232269e-01 0.035 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 9.235763e-01 0.035 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.268547e-01 0.033 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.268547e-01 0.033 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.268547e-01 0.033 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 9.273380e-01 0.033 0 0
Signaling downstream of RAS mutants R-HSA-9649948 9.273380e-01 0.033 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 9.273380e-01 0.033 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 9.273380e-01 0.033 0 0
Signaling by RAS mutants R-HSA-6802949 9.273380e-01 0.033 0 0
Signaling by VEGF R-HSA-194138 9.297730e-01 0.032 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.310200e-01 0.031 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.310200e-01 0.031 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.310200e-01 0.031 0 0
Creatine metabolism R-HSA-71288 9.310200e-01 0.031 0 0
Signal transduction by L1 R-HSA-445144 9.310200e-01 0.031 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.310200e-01 0.031 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 9.311400e-01 0.031 0 0
tRNA Aminoacylation R-HSA-379724 9.315576e-01 0.031 0 0
RAF activation R-HSA-5673000 9.329511e-01 0.030 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.329511e-01 0.030 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.329511e-01 0.030 0 0
PLC beta mediated events R-HSA-112043 9.361725e-01 0.029 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.369878e-01 0.028 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.376696e-01 0.028 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 9.376696e-01 0.028 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 9.380224e-01 0.028 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.380224e-01 0.028 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.380224e-01 0.028 0 0
Phenylalanine metabolism R-HSA-8964208 9.380224e-01 0.028 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.380224e-01 0.028 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.385640e-01 0.028 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.385640e-01 0.028 0 0
Glucose metabolism R-HSA-70326 9.387048e-01 0.027 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.387466e-01 0.027 0 0
Mitochondrial protein import R-HSA-1268020 9.405030e-01 0.027 0 0
Signaling by Interleukins R-HSA-449147 9.417303e-01 0.026 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.437288e-01 0.025 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 9.443144e-01 0.025 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 9.443144e-01 0.025 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.443144e-01 0.025 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 9.443144e-01 0.025 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.443144e-01 0.025 0 0
Ribavirin ADME R-HSA-9755088 9.443144e-01 0.025 0 0
Glutathione synthesis and recycling R-HSA-174403 9.443144e-01 0.025 0 0
Attachment and Entry R-HSA-9694614 9.443144e-01 0.025 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.445640e-01 0.025 0 0
Potential therapeutics for SARS R-HSA-9679191 9.449029e-01 0.025 0 0
Signaling by FGFR R-HSA-190236 9.449986e-01 0.025 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.454985e-01 0.024 0 0
Translation of Structural Proteins R-HSA-9694635 9.482476e-01 0.023 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.484785e-01 0.023 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.484785e-01 0.023 0 0
Cleavage of the damaged purine R-HSA-110331 9.484785e-01 0.023 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.484785e-01 0.023 0 0
NCAM1 interactions R-HSA-419037 9.484785e-01 0.023 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.499679e-01 0.022 0 0
FGFR2 alternative splicing R-HSA-6803529 9.499679e-01 0.022 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 9.499679e-01 0.022 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.499679e-01 0.022 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.499679e-01 0.022 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.506433e-01 0.022 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 9.519352e-01 0.021 0 0
Elastic fibre formation R-HSA-1566948 9.528442e-01 0.021 0 0
Depurination R-HSA-73927 9.528442e-01 0.021 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.532766e-01 0.021 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.532766e-01 0.021 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.547060e-01 0.020 0 0
Carnitine shuttle R-HSA-200425 9.550478e-01 0.020 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.550478e-01 0.020 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.550478e-01 0.020 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 9.568360e-01 0.019 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.568549e-01 0.019 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.568549e-01 0.019 0 0
G-protein mediated events R-HSA-112040 9.583949e-01 0.018 0 0
RAF/MAP kinase cascade R-HSA-5673001 9.585229e-01 0.018 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.596121e-01 0.018 0 0
Complex III assembly R-HSA-9865881 9.596121e-01 0.018 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.596121e-01 0.018 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.596121e-01 0.018 0 0
Metabolism of RNA R-HSA-8953854 9.601083e-01 0.018 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.605375e-01 0.017 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 9.605375e-01 0.017 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.605375e-01 0.017 0 0
Generation of second messenger molecules R-HSA-202433 9.605375e-01 0.017 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 9.605375e-01 0.017 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.605375e-01 0.017 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.606467e-01 0.017 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.610611e-01 0.017 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.615589e-01 0.017 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.628468e-01 0.016 0 0
MAPK family signaling cascades R-HSA-5683057 9.634595e-01 0.016 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.637132e-01 0.016 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.637132e-01 0.016 0 0
Long-term potentiation R-HSA-9620244 9.637132e-01 0.016 0 0
Tight junction interactions R-HSA-420029 9.637132e-01 0.016 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.637132e-01 0.016 0 0
Hyaluronan degradation R-HSA-2160916 9.637132e-01 0.016 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.637132e-01 0.016 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.639175e-01 0.016 0 0
Maturation of spike protein R-HSA-9694548 9.639175e-01 0.016 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 9.639175e-01 0.016 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 9.640432e-01 0.016 0 0
G alpha (z) signalling events R-HSA-418597 9.640477e-01 0.016 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.653926e-01 0.015 0 0
Platelet degranulation R-HSA-114608 9.664071e-01 0.015 0 0
G alpha (s) signalling events R-HSA-418555 9.668261e-01 0.015 0 0
HIV Transcription Initiation R-HSA-167161 9.670182e-01 0.015 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.670182e-01 0.015 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.670182e-01 0.015 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.670182e-01 0.015 0 0
Heme biosynthesis R-HSA-189451 9.670182e-01 0.015 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.673982e-01 0.014 0 0
TRP channels R-HSA-3295583 9.673982e-01 0.014 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.673982e-01 0.014 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 9.684073e-01 0.014 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.698615e-01 0.013 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.707091e-01 0.013 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.707091e-01 0.013 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.707091e-01 0.013 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 9.707091e-01 0.013 0 0
Triglyceride biosynthesis R-HSA-75109 9.707091e-01 0.013 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.707091e-01 0.013 0 0
Synthesis of PE R-HSA-1483213 9.707091e-01 0.013 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.707091e-01 0.013 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.707091e-01 0.013 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 9.717636e-01 0.012 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.724677e-01 0.012 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.724677e-01 0.012 0 0
Defective pyroptosis R-HSA-9710421 9.724677e-01 0.012 0 0
Formation of the Early Elongation Complex R-HSA-113418 9.736839e-01 0.012 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 9.736839e-01 0.012 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.736839e-01 0.012 0 0
Iron assimilation using enterobactin R-HSA-9638334 9.736839e-01 0.012 0 0
Pyrimidine salvage R-HSA-73614 9.736839e-01 0.012 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 9.736839e-01 0.012 0 0
Cardiac conduction R-HSA-5576891 9.747669e-01 0.011 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.748556e-01 0.011 0 0
EPHB-mediated forward signaling R-HSA-3928662 9.748556e-01 0.011 0 0
Amine ligand-binding receptors R-HSA-375280 9.748556e-01 0.011 0 0
Regulation of insulin secretion R-HSA-422356 9.750555e-01 0.011 0 0
GABA receptor activation R-HSA-977443 9.760055e-01 0.011 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.763568e-01 0.010 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.763568e-01 0.010 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 9.763568e-01 0.010 0 0
SLC transporter disorders R-HSA-5619102 9.766603e-01 0.010 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.770426e-01 0.010 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.770426e-01 0.010 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.775431e-01 0.010 0 0
Aquaporin-mediated transport R-HSA-445717 9.778920e-01 0.010 0 0
ABC-family proteins mediated transport R-HSA-382556 9.781687e-01 0.010 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.783138e-01 0.010 0 0
Interleukin-12 signaling R-HSA-9020591 9.786699e-01 0.009 0 0
ER-Phagosome pathway R-HSA-1236974 9.788154e-01 0.009 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 9.790450e-01 0.009 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.790450e-01 0.009 0 0
Adaptive Immune System R-HSA-1280218 9.791103e-01 0.009 0 0
Phospholipid metabolism R-HSA-1483257 9.791673e-01 0.009 0 0
HCMV Late Events R-HSA-9610379 9.791739e-01 0.009 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 9.808775e-01 0.008 0 0
Budding and maturation of HIV virion R-HSA-162588 9.809160e-01 0.008 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.809160e-01 0.008 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.809160e-01 0.008 0 0
Cargo concentration in the ER R-HSA-5694530 9.809160e-01 0.008 0 0
Metal ion SLC transporters R-HSA-425410 9.825542e-01 0.008 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.828547e-01 0.008 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.840877e-01 0.007 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.840877e-01 0.007 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.840930e-01 0.007 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.841062e-01 0.007 0 0
Developmental Biology R-HSA-1266738 9.844805e-01 0.007 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.845965e-01 0.007 0 0
Recycling of bile acids and salts R-HSA-159418 9.845965e-01 0.007 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 9.845965e-01 0.007 0 0
Amyloid fiber formation R-HSA-977225 9.854568e-01 0.006 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.854897e-01 0.006 0 0
Azathioprine ADME R-HSA-9748787 9.854897e-01 0.006 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.861615e-01 0.006 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.861615e-01 0.006 0 0
Heme degradation R-HSA-189483 9.861615e-01 0.006 0 0
Platelet homeostasis R-HSA-418346 9.864428e-01 0.006 0 0
The phototransduction cascade R-HSA-2514856 9.867713e-01 0.006 0 0
Complex IV assembly R-HSA-9864848 9.867713e-01 0.006 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.867713e-01 0.006 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.868256e-01 0.006 0 0
Protein localization R-HSA-9609507 9.871161e-01 0.006 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.875491e-01 0.005 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 9.875675e-01 0.005 0 0
Hyaluronan metabolism R-HSA-2142845 9.875675e-01 0.005 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 9.875675e-01 0.005 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.879423e-01 0.005 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.879423e-01 0.005 0 0
Influenza Infection R-HSA-168255 9.885096e-01 0.005 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.885537e-01 0.005 0 0
Regulation of Apoptosis R-HSA-169911 9.888308e-01 0.005 0 0
Neutrophil degranulation R-HSA-6798695 9.897219e-01 0.004 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.899657e-01 0.004 0 0
Glycosphingolipid transport R-HSA-9845576 9.899657e-01 0.004 0 0
Triglyceride catabolism R-HSA-163560 9.899657e-01 0.004 0 0
Translation initiation complex formation R-HSA-72649 9.899889e-01 0.004 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.901581e-01 0.004 0 0
Hedgehog 'on' state R-HSA-5632684 9.904102e-01 0.004 0 0
Metabolism of porphyrins R-HSA-189445 9.904102e-01 0.004 0 0
Paracetamol ADME R-HSA-9753281 9.908808e-01 0.004 0 0
Voltage gated Potassium channels R-HSA-1296072 9.909854e-01 0.004 0 0
Ubiquinol biosynthesis R-HSA-2142789 9.909854e-01 0.004 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.909854e-01 0.004 0 0
Collagen chain trimerization R-HSA-8948216 9.909854e-01 0.004 0 0
Metabolism of folate and pterines R-HSA-196757 9.909854e-01 0.004 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.910900e-01 0.004 0 0
Interleukin-12 family signaling R-HSA-447115 9.915976e-01 0.004 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 9.916949e-01 0.004 0 0
Ion homeostasis R-HSA-5578775 9.916949e-01 0.004 0 0
Parasitic Infection Pathways R-HSA-9824443 9.918006e-01 0.004 0 0
Leishmania infection R-HSA-9658195 9.918006e-01 0.004 0 0
Purine salvage R-HSA-74217 9.919016e-01 0.004 0 0
Synthesis of PA R-HSA-1483166 9.924378e-01 0.003 0 0
Dectin-2 family R-HSA-5621480 9.924378e-01 0.003 0 0
Pentose phosphate pathway R-HSA-71336 9.927246e-01 0.003 0 0
Neurotransmitter release cycle R-HSA-112310 9.933849e-01 0.003 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.933849e-01 0.003 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.934641e-01 0.003 0 0
Glycogen metabolism R-HSA-8982491 9.934641e-01 0.003 0 0
Triglyceride metabolism R-HSA-8979227 9.937336e-01 0.003 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.937336e-01 0.003 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.938159e-01 0.003 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.941285e-01 0.003 0 0
RAB geranylgeranylation R-HSA-8873719 9.942972e-01 0.002 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.942972e-01 0.002 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.943670e-01 0.002 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.947253e-01 0.002 0 0
ABC transporter disorders R-HSA-5619084 9.947380e-01 0.002 0 0
Collagen degradation R-HSA-1442490 9.948111e-01 0.002 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.952078e-01 0.002 0 0
Collagen formation R-HSA-1474290 9.955815e-01 0.002 0 0
Defensins R-HSA-1461973 9.957432e-01 0.002 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.957432e-01 0.002 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.958584e-01 0.002 0 0
Stimuli-sensing channels R-HSA-2672351 9.958584e-01 0.002 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.959270e-01 0.002 0 0
Ion transport by P-type ATPases R-HSA-936837 9.960950e-01 0.002 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.965413e-01 0.002 0 0
Potassium Channels R-HSA-1296071 9.965413e-01 0.002 0 0
The canonical retinoid cycle in rods (twilight vision) R-HSA-2453902 9.965648e-01 0.001 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 9.969141e-01 0.001 0 0
Ion channel transport R-HSA-983712 9.970348e-01 0.001 0 0
Synthesis of PC R-HSA-1483191 9.972279e-01 0.001 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.972980e-01 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 9.973328e-01 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.973328e-01 0.001 0 0
Selenocysteine synthesis R-HSA-2408557 9.977105e-01 0.001 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.980778e-01 0.001 0 0
Transmission across Chemical Synapses R-HSA-112315 9.981938e-01 0.001 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.983951e-01 0.001 0 0
Neuronal System R-HSA-112316 9.984419e-01 0.001 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.985008e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.985670e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.985670e-01 0.001 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.986387e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.990115e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.990921e-01 0.000 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.991038e-01 0.000 0 0
Ribosome-associated quality control R-HSA-9948299 9.991131e-01 0.000 0 0
Peroxisomal protein import R-HSA-9033241 9.992349e-01 0.000 0 0
Developmental Cell Lineages R-HSA-9734767 9.992600e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.993128e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.993128e-01 0.000 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.993542e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.993827e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.993827e-01 0.000 0 0
Viral Infection Pathways R-HSA-9824446 9.994072e-01 0.000 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.994992e-01 0.000 0 0
Cap-dependent Translation Initiation R-HSA-72737 9.995016e-01 0.000 0 0
Eukaryotic Translation Initiation R-HSA-72613 9.995016e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.995428e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.995497e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.995583e-01 0.000 0 0
Peptide chain elongation R-HSA-156902 9.996515e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.996759e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.996759e-01 0.000 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.997286e-01 0.000 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.997404e-01 0.000 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 9.997501e-01 0.000 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 9.997501e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.997651e-01 0.000 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.997868e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.997890e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.997890e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.997890e-01 0.000 0 0
Leishmania phagocytosis R-HSA-9664417 9.997911e-01 0.000 0 0
Parasite infection R-HSA-9664407 9.997911e-01 0.000 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.997911e-01 0.000 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.998079e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.998250e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.998298e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.998414e-01 0.000 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.998478e-01 0.000 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.998564e-01 0.000 0 0
Eukaryotic Translation Termination R-HSA-72764 9.998564e-01 0.000 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.998627e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.998699e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.998933e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999005e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.999005e-01 0.000 0 0
Integrin cell surface interactions R-HSA-216083 9.999005e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999107e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999280e-01 0.000 0 0
Viral mRNA Translation R-HSA-192823 9.999350e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999350e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999396e-01 0.000 0 0
rRNA processing R-HSA-72312 9.999450e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999468e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.999533e-01 0.000 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.999605e-01 0.000 0 0
Hemostasis R-HSA-109582 9.999638e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999648e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999661e-01 0.000 0 0
Immune System R-HSA-168256 9.999672e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999677e-01 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 9.999754e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999789e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999822e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999849e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999855e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999862e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999935e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999948e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999964e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999976e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999986e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999988e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999990e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999992e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999995e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999996e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999997e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999997e-01 0.000 0 0
Disease R-HSA-1643685 9.999997e-01 0.000 1 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999997e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Translation R-HSA-72766 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways