DYRK3

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0MZ66 S532 Sugiyama SHTN1 KIAA1598 sVssVTKTALNKKTLEAEFNsPsPPtPEPGEGPRKLEGCTS
A0MZ66 T537 Sugiyama SHTN1 KIAA1598 TKTALNKKTLEAEFNsPsPPtPEPGEGPRKLEGCTSSKVTF
A6NDS4 T152 Sugiyama TBC1D3B TBC1D3I KEKGKRSSEHIQRIDRDISGtLRKHMFFRDRYGTKQRELLH
B9A6J9 T152 Sugiyama TBC1D3L PRC17 KEKGKRSSEHIQRIDRDVSGtLRKHIFFRDRYGTKQRELLH
O00178 S12 Sugiyama GTPBP1 _________MATERsRsAMDsPVPAsMFAPEPssPGAARAA
O00178 S25 Sugiyama GTPBP1 RsRsAMDsPVPAsMFAPEPssPGAARAAAAAARLHGGFDsD
O00178 S6 Sugiyama GTPBP1 _______________MATERsRsAMDsPVPAsMFAPEPssP
O00178 S8 Sugiyama GTPBP1 _____________MATERsRsAMDsPVPAsMFAPEPssPGA
O00299 S146 Sugiyama CLIC1 G6 NCC27 NDNLEKGLLKALKVLDNyLTsPLPEEVDEtsAEDEGVsQRK
O00299 S221 Sugiyama CLIC1 G6 NCC27 EAFRGVHRYLsNAyAREEFAstCPDDEEIELAyEQVAKALK
O00429 S126 Sugiyama DNM1L DLP1 DRP1 EIRQEIENETERISGNNKGVsPEPIHLKIFSPNVVNLTLVD
O00468 S738 Sugiyama AGRN AGRIN CGSDGVTYSTECELKKARCEsQRGLYVAAQGACRGPTFAPL
O00571 S70 Sugiyama DDX3X DBX DDX3 KGFyDKDSSGWsssKDKDAyssFGsRsDsRGKssFFsDRGs
O14556 T301 Sugiyama GAPDHS GAPD2 GAPDH2 GAPDS HSD-35 HSD35 ASTGAAKAVTKVIPELKGKLtGMAFRVPTPDVSVVDLTCRL
O14639 S431 Sugiyama ABLIM1 ABLIM KIAA0059 LIMAB1 TSGYDDKQERQsLGEsPRtLsPtPsAEGyQDVRDRMIHRst
O14777 S66 Sugiyama NDC80 HEC HEC1 KNTC2 NKPtsERKVsLFGKRtsGHGsRNsQLGIFsssEKIKDPRPL
O14777 S69 Sugiyama NDC80 HEC HEC1 KNTC2 tsERKVsLFGKRtsGHGsRNsQLGIFsssEKIKDPRPLNDK
O15067 S1062 Sugiyama PFAS KIAA0361 SYCLPPTFPKAsVPREPGGPsPRVAILREEGSNGDREMADA
O15160 S258 Sugiyama POLR1C POLR1E DITLLEPVEGEAAEELSRCFsPGVIEVQEVQGKKVARVANP
O15355 T199 Sugiyama PPM1G PPM1C EEPGsQGLNGEAGPEDstREtPsQENGPtAKAyTGFssNsE
O15460 S531 Sugiyama P4HA2 UNQ290/PRO330 KWVSNKWFHERGQEFLRPCGstEVD________________
O15523 S70 Sugiyama DDX3Y DBY KGFHDKDSSGWSCSKDKDAyssFGsRDSRGKPGYFSERGSG
O43175 T78 Sugiyama PHGDH PGDH3 KVTADVINAAEKLQVVGRAGtGVDNVDLEAAtRKGILVMNT
O43390 S426 Sugiyama HNRNPR HNRPR IVLAKPPDKKRKERQAARQAsRstAyEDyyyHPPPRMPPPI
O43390 T429 Sugiyama HNRNPR HNRPR AKPPDKKRKERQAARQAsRstAyEDyyyHPPPRMPPPIRGR
O43488 S40 Sugiyama AKR7A2 AFAR AFAR1 AKR7 SPPPEARALAMSRPPPPRVAsVLGTMEMGRRMDAPAsAAAV
O43491 S386 Sugiyama EPB41L2 TQTKELEEKVAELHKTHRGLsPAQADsQFLENAKRLsMYGV
O43765 T81 Sugiyama SGTA SGT SGT1 IFEAAATGKEMPQDLRsPARtPPsEEDsAEAERLKTEGNEQ
O43781 S47 Sugiyama DYRK3 LGDGVyDtFMMIDETKCPPCsNVLCNPsEPPPPRRLNMTtE
O43781 S54 Sugiyama DYRK3 tFMMIDETKCPPCsNVLCNPsEPPPPRRLNMTtEQFTGDHt
O43781 T34 Sugiyama DYRK3 GPPGAGLPPQQRRLGDGVyDtFMMIDETKCPPCsNVLCNPs
O43781 T368 Sugiyama DYRK3 RSsTKVIDFGSSCFEYQKLYtyIQSRFYRAPEIILGSRYST
O43781 T66 Sugiyama DYRK3 CsNVLCNPsEPPPPRRLNMTtEQFTGDHtQHFLDGGEMKVE
O43781 T74 Sugiyama DYRK3 sEPPPPRRLNMTtEQFTGDHtQHFLDGGEMKVEQLFQEFGN
O43781 Y32 Sugiyama DYRK3 DAGPPGAGLPPQQRRLGDGVyDtFMMIDETKCPPCsNVLCN
O43781 Y369 Sugiyama DYRK3 SsTKVIDFGSSCFEYQKLYtyIQSRFYRAPEIILGSRYSTP
O43815 S229 Sugiyama STRN TEAEVKETAMIAKSELtDsAsVLDNFKFLEsAAADFsDEDE
O43823 S124 Sugiyama AKAP8 AKAP95 SKEGGRGGsGGGGEGIQDREssFRFQPFESYDSRPCLPEHN
O43852 T65 Sugiyama CALU FDyDHDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKD
O60216 S454 Sugiyama RAD21 HR21 KIAA0078 NXP1 SCC1 HQQRDVIDEPIIEEPsRLQEsVMEAsRTNIDESAMPPPPPQ
O60245 T251 Sugiyama PCDH7 BHPCDH GGGGTNPGGRsSVFELQVADtPDGEKQPQLIVKGALDREQR
O60271 S194 Sugiyama SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6 LERTKLHQLsGsDQLEstAHsRIRKERPIsLGIFPLPAGDG
O60573 S74 Sugiyama EIF4E2 EIF4EL3 HPLQYNYTFWYSRRtPGRPtsSQSyEQNIKQIGTFASVEQF
O60664 S175 Sugiyama PLIN3 M6PRBP1 TIP47 RGAVQSGVDKTKsVVtGGVQsVMGsRLGQMVLsGVDtVLGK
O60664 S179 Sugiyama PLIN3 M6PRBP1 TIP47 QSGVDKTKsVVtGGVQsVMGsRLGQMVLsGVDtVLGKsEEW
O60664 S225 Sugiyama PLIN3 M6PRBP1 TIP47 PLTDAELARIAtsLDGFDVAsVQQQRQEQSyFVRLGsLSER
O60664 T216 Sugiyama PLIN3 M6PRBP1 TIP47 sEEWADNHLPLTDAELARIAtsLDGFDVAsVQQQRQEQSyF
O60701 T185 Sugiyama UGDH EGTAIKDLKNPDRVLIGGDEtPEGQRAVQALCAVYEHWVPR
O60716 S252 Sugiyama CTNND1 KIAA0384 sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
O60716 S861 Sugiyama CTNND1 KIAA0384 KEGWKKsDFQVNLNNAsRsQssHsyDDstLPLIDRNQKsDK
O60763 S32 Sugiyama USO1 VDP SAGPQHTEAEtIQKLCDRVAssTLLDDRRNAVRALKSLSKK
O60763 S33 Sugiyama USO1 VDP AGPQHTEAEtIQKLCDRVAssTLLDDRRNAVRALKSLSKKY
O60763 S851 Sugiyama USO1 VDP VQGETETIIATKTTDVEGRLsALLQETKELKNEIKALSEER
O60841 S178 Sugiyama EIF5B IF2 KIAA0741 NKKWDGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRK
O60841 S182 Sugiyama EIF5B IF2 KIAA0741 DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O75122 S1029 Sugiyama CLASP2 KIAA0627 PtHssPRsRDyNPyNysDsIsPFNKsALKEAMFDDDADQFP
O75131 S242 Sugiyama CPNE3 CPN3 KIAA0636 SHDLIGTFQTTMTKLKEAsRssPVEFECINEKKRQKKKSYK
O75376 S157 Sugiyama NCOR1 KIAA1047 LRASADAKKDPAFGGKHEAPssPIsGQPCGDDQNAsPsKLS
O75822 T109 Sugiyama EIF3J EIF3S1 PRO0391 KKRQEEIKKRLEEPEEPKVLtPEEQLADKLRLKKLQEEsDL
O75822 T33 Sugiyama EIF3J EIF3S1 PRO0391 sWDADAFsVEDPVRKVGGGGtAGGDRWEGEDEDEDVKDNWD
O76021 S314 Sugiyama RSL1D1 CATX11 CSIG PBK1 L12 RNFEKQKERKKKRQQARKtAsVLsKDDVAPEsGDtTVKKPE
O94776 S435 Sugiyama MTA2 MTA1L1 PID RGtTEPHSRGHLsRPEAQsLsPyttsANRAKLLAKNRQtFL
O94826 S91 Sugiyama TOMM70 KIAA0719 TOM70 TOMM70A RGDASGLKRNSERKtPEGRAsPAPGsGHPEGPGAHLDMNsL
O94979 S799 Sugiyama SEC31A KIAA0905 SEC31L1 HSPC275 HSPC334 IMQLRDRLCRAQGEPVAGHEsPKIPyEKQQLPKGRPGPVAG
O95071 S110 Sugiyama UBR5 EDD EDD1 HYD KIAA0896 sKLNSNSGAGRTSRPGRTSDsPWFLsGSEtLGRLAGNTLGS
O95757 T35 Sugiyama HSPA4L APG1 HSPH3 OSP94 IAVARsGGIETIANEySDRCtPACIsLGSRTRAIGNAAKSQ
O95816 S208 Sugiyama BAG2 IKLLEHSKGAGSKTLQQNAEsRFN_________________
O95817 S173 Sugiyama BAG3 BIS QVAAAAAAQPPAsHGPERsQsPAAsDCsssSsSAsLPssGR
O95881 T159 Sugiyama TXNDC12 TLP19 UNQ713/PRO1376 yFyVsAEQVVQGMKEAQERLtGDAFRKKHLEDEL_______
P00338 S105 Sugiyama LDHA PIG19 VTANsKLVIItAGARQQEGEsRLNLVQRNVNIFKFIIPNVV
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00491 S176 Sugiyama PNP NP GDRFPAMsDAyDRtMRQRALstWKQMGEQRELQEGTYVMVA
P00558 S174 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 LSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKEL
P00558 S415 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 GGGAsLELLEGKVLPGVDALsNI__________________
P00966 T219 Sugiyama ASS1 ASS KNQAPPGLytKtQDPAKAPNtPDILEIEFKKGVPVKVTNVK
P02786 S654 Sugiyama TFRC EMGLSLQWLYSARGDFFRATsRLTTDFGNAEKTDRFVMKKL
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04406 T229 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 AstGAAKAVGKVIPELNGKLtGMAFRVPtANVsVVDLtCRL
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05023 S228 Sugiyama ATP1A1 ANGCKVDNssLtGESEPQtRsPDFtNENPLETRNIAFFSTN
P05023 S519 Sugiyama ATP1A1 sEPQHLLVMKGAPERILDRCssILLHGKEQPLDEELKDAFQ
P05187 S177 Sugiyama ALPP PLAP RAKKAGKSVGVVTTTRVQHAsPAGtyAHtVNRNWysDADVP
P05187 S438 Sugiyama ALPP PLAP GPGYVLKDGARPDVtEsEsGsPEyRQQSAVPLDEETHAGED
P05783 S177 Sugiyama KRT18 CYK18 PIG46 ARLAADDFRVKyETELAMRQsVENDIHGLRKVIDDTNItRL
P05783 S305 Sugiyama KRT18 CYK18 PIG46 QSAEVGAAETTLTELRRtVQsLEIDLDsMRNLKAsLENsLR
P05787 S258 Sugiyama KRT8 CYK8 QISDTSVVLsMDNSRsLDMDsIIAEVKAQyEDIANRsRAEA
P05787 S330 Sugiyama KRT8 CYK8 MNRNISRLQAEIEGLKGQRAsLEAAIADAEQRGELAIKDAN
P06733 S268 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 ASEFFRsGKyDLDFKsPDDPsRyIsPDQLADLyKsFIKDyP
P06733 S272 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 FRsGKyDLDFKsPDDPsRyIsPDQLADLyKsFIKDyPVVsI
P06733 Y270 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 EFFRsGKyDLDFKsPDDPsRyIsPDQLADLyKsFIKDyPVV
P07195 S106 Sugiyama LDHB VtANSKIVVVtAGVRQQEGEsRLNLVQRNVNVFKFIIPQIV
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195 T302 Sugiyama LDHB YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07355 S184 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK
P07437 Y50 Sugiyama TUBB TUBB5 OK/SW-cl.56 IDPTGtyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEP
P07737 S30 Sugiyama PFN1 NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07741 S30 Sugiyama APRT EQRIRsFPDFPTPGVVFRDIsPVLKDPASFRAAIGLLARHL
P07814 S1122 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 AWVtRSGKTELAEPIAIRPTsEtVMyPAyAKWVQSHRDLPI
P07814 T1124 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 VtRSGKTELAEPIAIRPTsEtVMyPAyAKWVQSHRDLPIKL
P07814 T737 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 EKTKVEATKNETSAPFKERPtPsLNNNCttsEDsLVLyNRV
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900 S623 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA tyGWTANMERIMKAQALRDNstMGyMAAKKHLEINPDHsII
P07942 S1115 Sugiyama LAMB1 SCNEFTGQCQCMPGFGGRTCsECQELFWGDPDVECRACDCD
P08195 S598 Sugiyama SLC3A2 MDU1 LQASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEP
P08195 S607 Sugiyama SLC3A2 MDU1 ASLPAKADLLLstQPGREEGsPLELERLKLEPHEGLLLRFP
P08238 S460 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ
P08670 S325 Sugiyama VIM NNDALRQAKQESTEYRRQVQsLtCEVDALKGtNEsLERQMR
P08865 S78 Sugiyama RPSA LAMBR LAMR1 LLLAARAIVAIENPADVsVIssRNtGQRAVLKFAAAtGAtP
P08865 S79 Sugiyama RPSA LAMBR LAMR1 LLAARAIVAIENPADVsVIssRNtGQRAVLKFAAAtGAtPI
P08865 T82 Sugiyama RPSA LAMBR LAMR1 ARAIVAIENPADVsVIssRNtGQRAVLKFAAAtGAtPIAGR
P09923 S174 Sugiyama ALPI RAKQAGKSVGVVTTTRVQHAsPAGtyAHtVNRNWysDADMP
P10696 S435 Sugiyama ALPG ALPPL ALPPL2 GPGYVLKDGARPDVtEsEsGsPEyRQQSAVPLDGETHAGED
P10809 S225 Sugiyama HSPD1 HSP60 KtLNDELEIIEGMKFDRGyIsPyFINtsKGQKCEFQDAyVL
P10809 T422 Sugiyama HSPD1 HSP60 AVLKVGGtsDVEVNEKKDRVtDALNAtRAAVEEGIVLGGGC
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142 T37 Sugiyama HSPA8 HSC70 HSP73 HSPA10 CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P11142 T38 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P11142 Y41 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P11532 S3623 Sugiyama DMD EAKVNGttVssPstsLQRsDssQPMLLRVVGSQTSDSMGEE
P11586 T378 Sugiyama MTHFD1 MTHFC MTHFD SALERLKHRPDGKyVVVTGItPtPLGEGKSTTTIGLVQALG
P11586 T380 Sugiyama MTHFD1 MTHFC MTHFD LERLKHRPDGKyVVVTGItPtPLGEGKSTTTIGLVQALGAH
P12270 S652 Sugiyama TPR sLDDVsLAstPKRPstsQtVstPAPVPVIESTEAIEAKAAL
P12277 S163 Sugiyama CKB CKBB PPHCsRGERRAIEKLAVEALssLDGDLAGRyyALKsMtEAE
P12277 T35 Sugiyama CKB CKBB PAEDEFPDLSAHNNHMAKVLtPELyAELRAKSTPSGFTLDD
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 S593 Sugiyama EEF2 EF2 SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13639 S595 Sugiyama EEF2 EF2 PVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGLAE
P13797 S339 Sugiyama PLS3 PRIDINMsGFNETDDLKRAEsMLQQADKLGCRQFVTPADVV
P13798 S97 Sugiyama APEH D3F15S2 D3S48E DNF15S2 VFAGPAGNSVETRGELLsREsPSGTMKAVLRKAGGTGPGEE
P13804 S192 Sugiyama ETFA sFDAAATsGGsASsEKAsStsPVEIsEWLDQKLTKSDRPEL
P13804 T191 Sugiyama ETFA tsFDAAATsGGsASsEKAsStsPVEIsEWLDQKLTKSDRPE
P13861 S307 Sugiyama PRKAR2A PKR2 PRKAR2 RIITQGEKADSFYIIESGEVsILIRSRTKSNKDGGNQEVEI
P13861 S92 Sugiyama PRKAR2A PKR2 PRKAR2 ADAKGDsEsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEE
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14314 S442 Sugiyama PRKCSH G19P1 EYVYRLCPFKLVSQKPKLGGsPtsLGtWGsWIGPDHDKFSA
P14314 T444 Sugiyama PRKCSH G19P1 VYRLCPFKLVSQKPKLGGsPtsLGtWGsWIGPDHDKFSAMK
P14625 S42 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 DDEVDVDGTVEEDLGKSREGsRtDDEVVQREEEAIQLDGLN
P14625 S552 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 KEKQDKIyFMAGsSRKEAEssPFVERLLKKGyEVIyLTEPV
P14866 S101 Sugiyama HNRNPL HNRPL P/OKcl.14 GAAGGGGGGENyDDPHKtPAsPVVHIRGLIDGVVEADLVEA
P15531 S122 Sugiyama NME1 NDPKA NM23 GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P15559 S82 Sugiyama NQO1 DIA4 NMOR1 DPANFQYPAESVLAYKEGHLsPDIVAEQKKLEAADLVIFQF
P15880 S190 Sugiyama RPS2 RPS4 WGNKIGKPHTVPCKVTGRCGsVLVRLIPAPRGtGIVsAPVP
P17066 T40 Sugiyama HSPA6 HSP70B' VGVFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQ
P17174 S82 Sugiyama GOT1 ANDNsLNHEyLPILGLAEFRsCAsRLALGDDsPALKEKRVG
P17174 S85 Sugiyama GOT1 NsLNHEyLPILGLAEFRsCAsRLALGDDsPALKEKRVGGVQ
P17174 S93 Sugiyama GOT1 PILGLAEFRsCAsRLALGDDsPALKEKRVGGVQsLGGtGAL
P17812 S568 Sugiyama CTPS1 CTPS VGRLSHYLQKGCRLsPRDtysDRsGsssPDsEItELKFPsI
P17812 S571 Sugiyama CTPS1 CTPS LSHYLQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD
P17812 S573 Sugiyama CTPS1 CTPS HYLQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD__
P17812 S575 Sugiyama CTPS1 CTPS LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P17980 S376 Sugiyama PSMC3 TBP1 MPNEEARARIMQIHSRKMNVsPDVNyEELARCTDDFNGAQC
P18615 S115 Sugiyama NELFE RD RDBP KLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLyEs
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P18827 S233 Sugiyama SDC1 SDC FETSGENTAVVAVEPDRRNQsPVDQGAtGAsQGLLDRKEVL
P18827 T240 Sugiyama SDC1 SDC TAVVAVEPDRRNQsPVDQGAtGAsQGLLDRKEVLGGVIAGG
P19338 S563 Sugiyama NCL CNKREIEGRAIRLELQGPRGsPNARSQPSKTLFVKGLsEDt
P21333 S1084 Sugiyama FLNA FLN FLN1 PTKPSKVKAFGPGLQGGsAGsPARFtIDTKGAGTGGLGLTV
P21333 S2319 Sugiyama FLNA FLN FLN1 VQEPGDyEVsVKFNEEHIPDsPFVVPVAsPsGDARRLtVss
P21333 S2327 Sugiyama FLNA FLN FLN1 VsVKFNEEHIPDsPFVVPVAsPsGDARRLtVssLQEsGLKV
P22626 S189 Sugiyama HNRNPA2B1 HNRPA2B1 IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P22626 S351 Sugiyama HNRNPA2B1 HNRPA2B1 yGGGNyGPGGsGGsGGyGGRsRy__________________
P23381 S378 Sugiyama WARS1 IFI53 WARS WRS sIFLtDtAKQIKTKVNKHAFsGGRDtIEEHRQFGGNCDVDV
P23381 T383 Sugiyama WARS1 IFI53 WARS WRS DtAKQIKTKVNKHAFsGGRDtIEEHRQFGGNCDVDVSFMYL
P23588 S311 Sugiyama EIF4B YRGGGDRYEDRYDRRDDRsWssRDDysRDDYRRDDRGPPQR
P23921 S559 Sugiyama RRM1 RR1 ALEASCDLAKEQGPyEtyEGsPVsKGILQYDMWNVTPTDLW
P23921 S780 Sugiyama RRM1 RR1 KEKVSKEEEEKERNtAAMVCsLENRDECLMCGS________
P23921 T774 Sugiyama RRM1 RR1 KEKLKDKEKVSKEEEEKERNtAAMVCsLENRDECLMCGS__
P25205 S447 Sugiyama MCM3 EQGRVTIAKAGIHARLNARCsVLAAANPVyGRyDQyKTPME
P25398 Y127 Sugiyama RPS12 sCVVVKDYGKESQAKDVIEEyFKCKK_______________
P25705 T64 Sugiyama ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM QKtGtAEMssILEERILGADtsVDLEETGRVLsIGDGIARV
P25786 S14 Sugiyama PSMA1 HC2 NU PROS30 PSC2 _______MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQGSA
P26232 T657 Sugiyama CTNNA2 CAPR EDDsDFEQEDYDVRsRtsVQtEDDQLIAGQsARAIMAQLPQ
P26373 S97 Sugiyama RPL13 BBC1 OK/SW-cl.46 sLEELRVAGIHKKVARTIGIsVDPRRRNKstEsLQANVQRL
P26885 S108 Sugiyama FKBP2 FKBP13 GWDQGLLGMCEGEKRKLVIPsELGyGERGAPPKIPGGATLV
P27708 S1038 Sugiyama CAD QLPNNMAMALHRQQCRVLGtsPEAIDSAENRFKFSRLLDTI
P27824 S362 Sugiyama CANX WDEDMDGEWEAPQIANPRCEsAPGCGVWQRPVIDNPNyKGK
P28066 S16 Sugiyama PSMA5 _____MFLTRsEyDRGVNtFsPEGRLFQVEyAIEAIKLGST
P28066 S179 Sugiyama PSMA5 sGtFVQCDARAIGsAsEGAQssLQEVyHKSMTLKEAIKSSL
P29401 S295 Sugiyama TKT ysQIQsKKKILAtPPQEDAPsVDIANIRMPsLPsyKVGDKI
P29401 S548 Sugiyama TKT NIRVLDPFTIKPLDRKLILDsARAtKGRILTVEDHYYEGGI
P29401 T287 Sugiyama TKT AEQIIQEIysQIQsKKKILAtPPQEDAPsVDIANIRMPsLP
P29401 T552 Sugiyama TKT LDPFTIKPLDRKLILDsARAtKGRILTVEDHYYEGGIGEAV
P29692 S133 Sugiyama EEF1D EF1D NVLEKssPGHRAtAPQtQHVsPMRQVEPPAKKPAtPAEDDE
P30041 T221 Sugiyama PRDX6 AOP2 KIAA0106 LFPKGVFtKELPSGKKYLRYtPQP_________________
P30041 T44 Sugiyama PRDX6 AOP2 KIAA0106 RFHDFLGDSWGILFSHPRDFtPVCttELGRAAKLAPEFAKR
P30041 T48 Sugiyama PRDX6 AOP2 KIAA0106 FLGDSWGILFSHPRDFtPVCttELGRAAKLAPEFAKRNVKL
P30043 T190 Sugiyama BLVRB FLR SCAN RGPSRVISKHDLGHFMLRCLttDEyDGHstyPsHQyQ____
P30086 S52 Sugiyama PEBP1 PBP PEBP AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P30101 S126 Sugiyama PDIA3 ERP57 ERP60 GRP58 FRDGEEAGAyDGPRtADGIVsHLKKQAGPASVPLRTEEEFK
P30101 T485 Sugiyama PDIA3 ERP57 ERP60 GRP58 KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P30533 S350 Sugiyama LRPAP1 A2MRAP RTKELGYTVKKHLQDLSGRIsRARHNEL_____________
P30566 S407 Sugiyama ADSL AMPS MAMVKAGGSRQDCHEKIRVLsQQAAsVVKQEGGDNDLIERI
P31327 S759 Sugiyama CPS1 AKIALGIPLPEIKNVVSGKTsACFEPSLDyMVtKIPRWDLD
P31943 S104 Sugiyama HNRNPH1 HNRPH HNRPH1 EVFKSNNVEMDWVLKHtGPNsPDtANDGFVRLRGLPFGCSK
P31943 T152 Sugiyama HNRNPH1 HNRPH HNRPH1 SGLEIVPNGITLPVDFQGRStGEAFVQFAsQEIAEKALKKH
P33176 S175 Sugiyama KIF5B KNS KNS1 VHEDKNRVPYVKGCTERFVCsPDEVMDtIDEGKSNRHVAVT
P33316 S88 Sugiyama DUT RGASTVGAAGWKGELPKAGGsPAPGPEtPAIsPsKRARPAE
P33992 S483 Sugiyama MCM5 CDC46 EQQTISIAKAGITTTLNSRCsVLAAANsVFGRWDETKGEDN
P33992 S490 Sugiyama MCM5 CDC46 AKAGITTTLNSRCsVLAAANsVFGRWDETKGEDNIDFMPTI
P34896 T405 Sugiyama SHMT1 NKNTCPGDRSALRPSGLRLGtPALTSRGLLEKDFQKVAHFI
P34897 S90 Sugiyama SHMT2 GLELIAsENFCsRAALEALGsCLNNKYSEGYPGKRyyGGAE
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34931 T39 Sugiyama HSPA1L CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P34931 T40 Sugiyama HSPA1L VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P34931 Y43 Sugiyama HSPA1L FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P34932 S40 Sugiyama HSPA4 APG2 HSPH2 AGGIETIANEysDRCtPACIsFGPKNRSIGAAAKSQVISNA
P35221 T658 Sugiyama CTNNA1 LDDsDFEtEDFDVRsRtsVQtEDDQLIAGQsARAIMAQLPQ
P35579 S1892 Sugiyama MYH9 LKQLKRQLEEAEEEAQRANAsRRKLQRELEDAtEtADAMNR
P35580 S1013 Sugiyama MYH10 QNSKFIKEKKLMEDRIAECssQLAEEEEKAKNLAKIRNKQE
P35611 S12 Sugiyama ADD1 ADDA _________MNGDsRAAVVtsPPPttAPHKERyFDRVDENN
P35613 S246 Sugiyama BSG UNQ6505/PRO21383 VKssEHINEGEtAMLVCKSEsVPPVTDWAWyKITDSEDKAL
P35658 S678 Sugiyama NUP214 CAIN CAN KIAA0023 PVPsMVQKSPRItPPAAKPGsPQAKSLQPAVAEKQGHQWKD
P35658 T670 Sugiyama NUP214 CAIN CAN KIAA0023 RSAQGSSSPVPsMVQKSPRItPPAAKPGsPQAKSLQPAVAE
P35998 T193 Sugiyama PSMC2 MSS1 TYSDVGGCKEQIEKLREVVEtPLLHPERFVNLGIEPPKGVL
P36578 S55 Sugiyama RPL4 RPL1 DIVNFVHTNLRKNNRQPyAVsELAGHQtsAEsWGtGRAVAR
P36578 T62 Sugiyama RPL4 RPL1 TNLRKNNRQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGG
P36871 S485 Sugiyama PGM1 VYtVEKADNFEysDPVDGsIsRNQGLRLIFTDGSRIVFRLs
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37837 S13 Sugiyama TALDO1 TAL TALDO TALDOR ________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646 T87 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKR
P38646 T94 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 QAKVLENAEGARttPsVVAFtADGERLVGMPAKRQAVtNPN
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40925 T156 Sugiyama MDH1 MDHA NCLtAsKSAPSIPKENFsCLtRLDHNRAKAQIALKLGVTAN
P41091 S107 Sugiyama EIF2S3 EIF2G KIYKLDDPSCPRPECyRSCGsstPDEFPtDIPGtKGNFKLV
P41091 T109 Sugiyama EIF2S3 EIF2G YKLDDPSCPRPECyRSCGsstPDEFPtDIPGtKGNFKLVRH
P42166 T160 Sugiyama TMPO LAP2 KLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsNDs
P42167 T160 Sugiyama TMPO LAP2 KLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSNDS
P42677 T74 Sugiyama RPS27 MPS1 VLCVGCSTVLCQPTGGKARLtEGCsFRRKQH__________
P46777 S230 Sugiyama RPL5 MSTP030 yLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAHAAIREN
P46777 T232 Sugiyama RPL5 MSTP030 MEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAHAAIRENPV
P46783 S146 Sugiyama RPS10 TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P46940 S727 Sugiyama IQGAP1 KIAA0051 WDEPPNFVQNSMQLSREEIQsSIsGVTAAYNREQLWLANEG
P47712 S412 Sugiyama PLA2G4A CPLA2 PLA2G4 VWGSAFSILFNRVLGVSGSQsRGstMEEELENIttKHIVsN
P47712 S415 Sugiyama PLA2G4A CPLA2 PLA2G4 SAFSILFNRVLGVSGSQsRGstMEEELENIttKHIVsNDss
P47712 S724 Sugiyama PLA2G4A CPLA2 PLA2G4 NIDVIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFL
P47712 S727 Sugiyama PLA2G4A CPLA2 PLA2G4 VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P48444 S252 Sugiyama ARCN1 COPD GKEVDNFVDKLKsEGEtIMSssMGKRTSEATKMHAPPINME
P48506 S215 Sugiyama GCLC GLCL GLCLC HRRGEKVVINVPIFKDKNtPsPFIETFTEDDEASRASKPDH
P48506 T213 Sugiyama GCLC GLCL GLCLC IRHRRGEKVVINVPIFKDKNtPsPFIETFTEDDEASRASKP
P48741 T40 Sugiyama HSPA7 HSP70B VGVFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQ
P49023 S303 Sugiyama PXN QRADGERCWAAGWPRDGGRssPGGQDEGGFMAQGKtGsssP
P49023 S85 Sugiyama PXN PLDQWQPSSSRFIHQQPQsssPVyGssAKtssVsNPQDsVG
P49327 S831 Sugiyama FASN FAS NPNALFPPVEFPAPRGtPLIsPLIKWDHSLAWDVPAAEDFP
P49327 S974 Sugiyama FASN FAS VSGKVyQWDDPDPRLFDHPEsPtPNPTEPLFLAQAEVYKEL
P49327 T827 Sugiyama FASN FAS GIDANPNALFPPVEFPAPRGtPLIsPLIKWDHSLAWDVPAA
P49327 T976 Sugiyama FASN FAS GKVyQWDDPDPRLFDHPEsPtPNPTEPLFLAQAEVYKELRL
P49407 T410 Sugiyama ARRB1 ARR1 DFARQRLKGMKDDKEEEEDGtGsPQLNNR____________
P49419 S84 Sugiyama ALDH7A1 ATQ1 EVIttyCPANNEPIARVRQAsVADyEEtVKKAREAWKIWAD
P49585 S68 Sugiyama PCYT1A CTPCT PCYT1 SDEIEVDFSKPYVRVTMEEAsRGtPCERPVRVYADGIFDLF
P49585 T71 Sugiyama PCYT1A CTPCT PCYT1 IEVDFSKPYVRVTMEEAsRGtPCERPVRVYADGIFDLFHSG
P49792 S14 Sugiyama RANBP2 NUP358 _______MRRSKADVERyIAsVQGstPsPRQKSMKGFYFAK
P49792 S21 Sugiyama RANBP2 NUP358 MRRSKADVERyIAsVQGstPsPRQKSMKGFYFAKLYYEAKE
P49959 T524 Sugiyama MRE11 HNGS1 MRE11A FRETRQKNTNEEDDEVREAMtRARALRsQSEESASAFSADD
P50395 S396 Sugiyama GDI2 RABGDIB IEQKFVsISDLLVPKDLGtEsQIFIsRTyDAttHFEttCDD
P51812 S715 Sugiyama RPS6KA3 ISPK1 MAPKAPK1B RSK2 APHLVKGAMAAtysALNRNQsPVLEPVGRsTLAQRRGIKKI
P52907 S123 Sugiyama CAPZA1 KEAsDPQPEEADGGLKsWREsCDsALRAYVKDHYSNGFCTV
P52907 S126 Sugiyama CAPZA1 sDPQPEEADGGLKsWREsCDsALRAYVKDHYSNGFCTVYAK
P53365 S260 Sugiyama ARFIP2 POR1 TDLEELsLGPRDAGTRGRLEsAQATFQAHRDKYEKLRGDVA
P53396 S457 Sugiyama ACLY FLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMPQD
P53396 S656 Sugiyama ACLY IGNTGGMLDNILASKLyRPGsVAyVSRsGGMsNELNNIISR
P54578 S431 Sugiyama USP14 TGT GSNNCGYYDLQAVLTHQGRSssSGHyVSWVKRKQDEWIKFD
P54578 S432 Sugiyama USP14 TGT SNNCGYYDLQAVLTHQGRSssSGHyVSWVKRKQDEWIKFDD
P54646 S176 Sugiyama PRKAA2 AMPK AMPK2 ADFGLSNMMsDGEFLRtsCGsPNyAAPEVISGRLYAGPEVD
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P54652 T38 Sugiyama HSPA2 CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P54652 T39 Sugiyama HSPA2 VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P54652 Y42 Sugiyama HSPA2 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P55072 S718 Sugiyama VCP HEL-220 HEL-S-70 AIREsIEsEIRRERERQtNPsAMEVEEDDPVPEIRRDHFEE
P55072 T715 Sugiyama VCP HEL-220 HEL-S-70 CKLAIREsIEsEIRRERERQtNPsAMEVEEDDPVPEIRRDH
P55209 T62 Sugiyama NAP1L1 NRP MMQNPQILAALQERLDGLVEtPtGyIEsLPRVVKRRVNALK
P55795 S104 Sugiyama HNRNPH2 FTP3 HNRPH2 EVFKSNsVEMDWVLKHtGPNsPDtANDGFVRLRGLPFGCSK
P55795 T152 Sugiyama HNRNPH2 FTP3 HNRPH2 SGLEIVPNGMTLPVDFQGRStGEAFVQFAsQEIAEKALKKH
P55809 S509 Sugiyama OXCT1 OXCT SCOT LWEGLTVDDVQKSTGCDFAVsPKLMPMQQIAN_________
P55884 S185 Sugiyama EIF3B EIF3S9 EEELLGDVLKDRPQEADGIDsVIVVDNVPQVGPDRLEKLKN
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60174 Y209 Sugiyama TPI1 TPI LRGWLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDG
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60866 T6 Sugiyama RPS20 _______________MAFKDtGKtPVEPEVAIHRIRITLTS
P61254 S32 Sugiyama RPL26 sKNRKRHFNAPsHIRRKIMssPLSKELRQKYNVRSMPIRKD
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61353 S39 Sugiyama RPL27 SGRKAVIVKNIDDGtsDRPysHALVAGIDRyPRKVTAAMGK
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61978 T39 Sugiyama HNRNPK HNRPK FGKRPAEDMEEEQAFKRsRNtDEMVELRILLQSKNAGAVIG
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62263 S114 Sugiyama RPS14 PRO2640 HIKLRATGGNRtKtPGPGAQsALRALARSGMKIGRIEDVtP
P62263 T107 Sugiyama RPS14 PRO2640 ELGITALHIKLRATGGNRtKtPGPGAQsALRALARSGMKIG
P62263 T133 Sugiyama RPS14 PRO2640 QsALRALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL__
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62714 T78 Sugiyama PPP2CB VHGQFHDLMELFRIGGKsPDtNyLFMGDyVDRGYYSVETVT
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62750 T42 Sugiyama RPL23A LKAKKAVLKGVHSHKKKKIRtsPTFRRPKTLRLRRQPKYPR
P62917 S14 Sugiyama RPL8 _______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P62979 S123 Sugiyama RPS27A UBA80 UBCEP1 LKYYKVDENGKIsRLRRECPsDECGAGVFMAsHFDRHyCGK
P63104 S28 Sugiyama YWHAZ QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P67775 T78 Sugiyama PPP2CA VHGQFHDLMELFRIGGKsPDtNyLFMGDyVDRGYYSVETVT
P67809 S102 Sugiyama YBX1 NSEP1 YB1 EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P67809 S209 Sugiyama YBX1 NSEP1 YB1 RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68400 T13 Sugiyama CSNK2A1 CK2A1 ________MSGPVPSRARVytDVNTHRPREYWDYESHVVEW
P68431 T46 Sugiyama H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J ARKsAPATGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
P78417 S13 Sugiyama GSTO1 GSTTLP28 ________MSGESARsLGKGsAPPGPVPEGsIRIySMRFCP
P84098 S12 Sugiyama RPL19 _________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
P84243 T46 EPSD|Sugiyama H3-3A H3.3A H3F3 H3F3A PP781; H3-3B H3.3B H3F3B ARKsAPsTGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
P85037 T436 Sugiyama FOXK1 MNF sAPAsPtHPGLMsPRsGGLQtPECLsREGsPIPHDPEFGsK
Q00613 S363 Sugiyama HSF1 HSTF1 AsVTALtDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNE
Q01082 S2197 Sugiyama SPTBN1 SPTB2 KTALPAQsAAtLPARtQEtPsAQMEGFLNRKHEWEAHNKKA
Q01082 T2195 Sugiyama SPTBN1 SPTB2 KAKTALPAQsAAtLPARtQEtPsAQMEGFLNRKHEWEAHNK
Q01105 T169 Sugiyama SET NKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQNK
Q02790 S15 Sugiyama FKBP4 FKBP52 ______MTAEEMKAtEsGAQsAPLPMEGVDIsPKQDEGVLK
Q04637 T207 Sugiyama EIF4G1 EIF4F EIF4G EIF4GI QGGKDITEEIMsGARtAstPtPPQtGGGLEPQANGEtPQVA
Q07021 T163 Sugiyama C1QBP GC1QBP HABP1 SF2P32 FDGEEEPSQGQKVEEQEPELtstPNFVVEVIKNDDGKKALV
Q07021 T165 Sugiyama C1QBP GC1QBP HABP1 SF2P32 GEEEPSQGQKVEEQEPELtstPNFVVEVIKNDDGKKALVLD
Q07157 S1065 Sugiyama TJP1 ZO1 YVEKQAsRDLEQPtyRyEsssytDQFsRNYEHRLRYEDRVP
Q07960 S51 Sugiyama ARHGAP1 CDC42GAP RHOGAP1 KNWPsDEMPDFPKsDDsKsssPELVtHLKWDDPyyDIARHQ
Q08J23 S383 Sugiyama NSUN2 SAKI TRM4 QWKVMTKDGQWFTDWDAVPHsRHTQIRPTMFPPKDPEKLQA
Q09666 S230 Sugiyama AHNAK PM227 sGsGAAsPtGsAVDIRAGAIsAsGPELQGAGHsKLQVTMPG
Q12765 T320 Sugiyama SCRN1 KIAA0193 PSRSIFKPFIFVDDVKLVPKtQsPCFGDDDPAKKEPRFQEK
Q12789 S848 Sugiyama GTF3C1 ERRTIKQESGRAGVRPsssGsAWEACSEAPSKGSQDGVTWE
Q12792 S143 Sugiyama TWF1 PTK9 GTVKEDVSLHGYKKyLLsQssPAPLtAAEEELRQIKINEVQ
Q13098 S483 Sugiyama GPS1 COPS1 CSN1 QIHVKsPPREGsQGELtPANsQsRMstNM____________
Q13131 S187 Sugiyama PRKAA1 AMPK1 ADFGLsNMMsDGEFLRtsCGsPNyAAPEVISGRLYAGPEVD
Q13242 S211 Sugiyama SRSF9 SFRS9 SRP30C GYsRsRSGsRGRDsPyQsRGsPHyFsPFRPy__________
Q13242 S216 Sugiyama SRSF9 SFRS9 SRP30C RSGsRGRDsPyQsRGsPHyFsPFRPy_______________
Q13247 S303 Sugiyama SRSF6 SFRS6 SRP55 ENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKRAT
Q13263 S473 Sugiyama TRIM28 KAP1 RNF96 TIF1B sGDDPyssAEPHVsGVKRsRsGEGEVsGLMRKVPRVsLERL
Q13263 T415 Sugiyama TRIM28 KAP1 RNF96 TIF1B LNAWTKSAEAFGKIVAERPGtNstGPAPMAPPRAPGPLSKQ
Q13283 S231 Sugiyama G3BP1 G3BP QEEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsW
Q13283 S232 Sugiyama G3BP1 G3BP EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13283 T241 Sugiyama G3BP1 G3BP ETAPEDAQKsssPAPADIAQtVQEDLRtFsWAsVtsKNLPP
Q13438 S653 Sugiyama OS9 AQKERQRQKELESNYRRVWGsPGGEGTGDLDEFDF______
Q13442 S19 Sugiyama PDAP1 HASPP28 __MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEEE
Q13442 T18 Sugiyama PDAP1 HASPP28 ___MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEE
Q13464 T233 Sugiyama ROCK1 KLADFGtCMKMNKEGMVRCDtAVGtPDyIsPEVLKSQGGDG
Q13464 T237 Sugiyama ROCK1 FGtCMKMNKEGMVRCDtAVGtPDyIsPEVLKSQGGDGYYGR
Q13610 S65 Sugiyama PWP1 EEGGGsDEEEtGsPsEDGMQsARTQARPREPLEDGDPEDDR
Q14103 S190 Sugiyama HNRNPD AUF1 HNRPD KRAKAMKTKEPVKKIFVGGLsPDtPEEKIREYFGGFGEVES
Q14103 T193 Sugiyama HNRNPD AUF1 HNRPD KAMKTKEPVKKIFVGGLsPDtPEEKIREYFGGFGEVESIEL
Q14151 S818 Sugiyama SAFB2 KIAA0138 QHYGDDRHGHGGPPERHGRDsRDGWGGyGsDKRLsEGRGLP
Q14152 S1028 Sugiyama EIF3A EIF3S10 KIAA0139 NWRHADDDRPPRRGLDEDRGsWRtADEDRGPRRGMDDDRGP
Q14152 S584 Sugiyama EIF3A EIF3S10 KIAA0139 EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14152 T1379 Sugiyama EIF3A EIF3S10 KIAA0139 EKDREsLRRTKNEtDEDGWttVRR_________________
Q14160 S1475 Sugiyama SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL GAPVRTAKAERRHQERLRVQsPEPPAPERALsPAELRALEA
Q14160 S504 Sugiyama SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL MKRSIEGRRsEACPCQPDsGsPLPAEEEKRLsAESGLSEDS
Q14203 S31 Sugiyama DCTN1 RTPSGSRMsAEASARPLRVGsRVEVIGKGHRGTVAYVGATL
Q14204 S3082 Sugiyama DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325 LHVVFTMNPSSEGLKDRAAtsPALFNRCVLNWFGDWSTEAL
Q14247 S405 Sugiyama CTTN EMS1 EEARRKLEEQARAKtQtPPVsPAPQPtEERLPssPVyEDAA
Q14247 S418 Sugiyama CTTN EMS1 KtQtPPVsPAPQPtEERLPssPVyEDAAsFKAELsyRGPVs
Q14247 T401 Sugiyama CTTN EMS1 RQEQEEARRKLEEQARAKtQtPPVsPAPQPtEERLPssPVy
Q14258 S100 Sugiyama TRIM25 EFP RNF147 ZNF147 DLAREPPADVWtPPARAsAPsPNAQVACDHCLKEAAVKTCL
Q14498 S334 Sugiyama RBM39 HCC1 RNPC2 FELAGRPMKVGHVTERtDAssAssFLDsDELERtGIDLGtT
Q14566 S268 Sugiyama MCM6 LIVVPDVSKLSTPGARAEtNsRVsGVDGyEtEGIRGLRALG
Q14566 T266 Sugiyama MCM6 GTLIVVPDVSKLSTPGARAEtNsRVsGVDGyEtEGIRGLRA
Q14974 S12 Sugiyama KPNB1 NTF97 _________MELITILEKtVsPDRLELEAAQKFLERAAVEN
Q15003 S81 Sugiyama NCAPH BRRN BRRN1 CAPH KIAA0074 EKERLQRRRsRVFDLQFstDsPRLLAsPsSRsIDIsATIPK
Q15084 S394 Sugiyama PDIA6 ERP5 P5 TXNDC7 GsFsEQGINEFLRELsFGRGstAPVGGGAFPtIVEREPWDG
Q15084 T395 Sugiyama PDIA6 ERP5 P5 TXNDC7 sFsEQGINEFLRELsFGRGstAPVGGGAFPtIVEREPWDGR
Q15293 T76 Sugiyama RCN1 RCN FQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGD
Q15424 S794 Sugiyama SAFB HAP HET SAFB1 EREGQHYPERHGGPERHGRDsRDGWGGyGsDKRMsEGRGLP
Q15637 S80 Sugiyama SF1 ZFM1 ZNF162 DLTRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFR
Q15637 S82 Sugiyama SF1 ZFM1 ZNF162 TRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFRTR
Q15642 S296 Sugiyama TRIP10 CIP4 STOT STP FARPGDVEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRS
Q15642 T302 Sugiyama TRIP10 CIP4 STOT STP VEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRSRTKRWP
Q15738 S106 Sugiyama NSDHL H105E3 CSRQDLyPALKGVNTVFHCAsPPPSSNNKELFYRVNYIGTK
Q15758 S493 Sugiyama SLC1A5 ASCT2 M7V1 RDR RDRC EGDALGAGLLQNYVDRtEsRstEPELIQVKsELPLDPLPVP
Q15773 S240 Sugiyama MLF2 GGRRAEGPPRLAIQGPEDsPsRQsRRYDW____________
Q15814 S330 Sugiyama TBCC RSKNNWNDVDDFNWLARDMAsPNWsILPEEERNIQWD____
Q15814 S334 Sugiyama TBCC NWNDVDDFNWLARDMAsPNWsILPEEERNIQWD________
Q16630 T157 Sugiyama CPSF6 CFIM68 SKKLMDLLPKRELHGQNPVVtPCNKQFLsQFEMQSRKTTQS
Q16637 S31 Sugiyama SMN1 SMN SMNT; SMN2 SMNC GVPEQEDsVLFRRGtGQsDDsDIWDDtALIKAYDKAVAsFK
Q16637 T25 Sugiyama SMN1 SMN SMNT; SMN2 SMNC sGGsGGGVPEQEDsVLFRRGtGQsDDsDIWDDtALIKAYDK
Q16695 T46 Sugiyama H3-4 H3FT HIST3H3 ARKsAPATGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
Q27J81 S826 Sugiyama INF2 C14orf151 C14orf173 EEAEKSHPDLLQLPRDLEQPsQAAGINLEIIRSEASSNLKK
Q4G0J3 S258 Sugiyama LARP7 HDCMA18P EENMDtsNtsIsKMKRsRPtsEGsDIEstEPQKQCSKKKKK
Q4V328 S690 Sugiyama GRIPAP1 KIAA1167 FsYREILREKEssAVPARsLsssPQAQPPRPAELsDEEVAE
Q4V328 S692 Sugiyama GRIPAP1 KIAA1167 YREILREKEssAVPARsLsssPQAQPPRPAELsDEEVAELF
Q53EL6 S94 Sugiyama PDCD4 H731 GDsVsDsGsDALRSGLtVPtsPKGRLLDRRSRSGKGRGLPK
Q5JSH3 S561 Sugiyama WDR44 RPH11 KNAFDYFNNMRMKYNtEGRVsPsPsQEsLsssKsDTDtGVC
Q5T4S7 S3846 Sugiyama UBR4 KIAA0462 KIAA1307 RBAF600 KELLEYDLQQREAATKSSRTsVQPTFTASQyRALsVLGCGH
Q5T4S7 T905 Sugiyama UBR4 KIAA0462 KIAA1307 RBAF600 LSPPFGWASGSQDSNSRRAttPLYHGFKEVEENWSKHFSSD
Q6DHY5 T152 Sugiyama TBC1D3G KEKGKRSSEHIQRIDRDISGtLRKHMFFRDRYGTKQRELLH
Q6IPX1 T152 Sugiyama TBC1D3C TBC1D3D KEKGKRSSEHIQRIDRDVSGtLRKHIFFRDRYGTKQRELLH
Q6NW29 S28 Sugiyama RWDD4 FAM28A RWDD4A EMELEALRSIyEGDEsFRELsPVSFQyRIGENGDPKAFLIE
Q6NXT2 T45 Sugiyama H3-5 H3F3C AARKSTPSTCGVKPHRyRPGtVALREIRRYQKstELLIRKL
Q6UN15 S492 Sugiyama FIP1L1 FIP1 RHE DRDRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAE
Q6UN15 T494 Sugiyama FIP1L1 FIP1 RHE DRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAERG
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q71DI3 T46 Sugiyama H3C15 HIST2H3A; H3C14 H3F2 H3FM HIST2H3C; H3C13 HIST2H3D ARKsAPATGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
Q71RC2 S594 Sugiyama LARP4 PP13296 GLNQttIPVsPPsttKPsRAstAsPCNNNINAAtAVALQEP
Q71RC2 S597 Sugiyama LARP4 PP13296 QttIPVsPPsttKPsRAstAsPCNNNINAAtAVALQEPRKL
Q71UM5 T74 Sugiyama RPS27L VLCVGCSTVLCQPTGGKARLtEGCsFRRKQH__________
Q7KZF4 T240 Sugiyama SND1 TDRD11 TVMLSGIKCPTFRREADGsEtPEPFAAEAKFFTESRLLQRD
Q7Z2W4 T273 Sugiyama ZC3HAV1 ZC3HDC2 PRO1677 FFQGsQEFLASASAsAERsCtPsPDQIsHRAsLEDAPVDDL
Q7Z417 S692 Sugiyama NUFIP2 KIAA1321 PIG1 IWNLQKQDPKRIItyNEAMDsPDQ_________________
Q7Z4V5 S301 Sugiyama HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 EKPLPKPRGRKPKPERPPSssSSDSDSDEVDRISEWKRRDE
Q7Z6Z7 S2887 Sugiyama HUWE1 KIAA0312 KIAA1578 UREB1 HSPC272 LEEAVGDTSAAGSSEQPRAGsstPGDAPPAVAEVQGRSDGs
Q86VP6 S376 Sugiyama CAND1 KIAA0829 TIP120 TIP120A CLDAVVSTRHEMLPEFyKTVsPALISRFKEREENVKADVFH
Q86WR0 S187 Sugiyama CCDC25 KKREKEEMKKKREMDELRSYssLMKVENMSSNQDGNDsDEF
Q8IWW6 S240 Sugiyama ARHGAP12 SSSsTEQIRAttPPNQGRPDsPVyANLQELKISQSALPPLP
Q8IWW6 T231 Sugiyama ARHGAP12 QDSEsGDELSSSsTEQIRAttPPNQGRPDsPVyANLQELKI
Q8IZ21 S118 Sugiyama PHACTR4 PRO2963 PSDAMLKNGHTTPIGNARsssPVQVEEEPVRLAsLRKAIPE
Q8N122 S696 Sugiyama RPTOR KIAA1303 RAPTOR SNFCTVALQFIEEEKNYALPsPATTEGGSLtPVRDsPCtPR
Q8N122 S711 Sugiyama RPTOR KIAA1303 RAPTOR NYALPsPATTEGGSLtPVRDsPCtPRLRsVssYGNIRAVAT
Q8N122 T706 Sugiyama RPTOR KIAA1303 RAPTOR IEEEKNYALPsPATTEGGSLtPVRDsPCtPRLRsVssYGNI
Q8N122 T714 Sugiyama RPTOR KIAA1303 RAPTOR LPsPATTEGGSLtPVRDsPCtPRLRsVssYGNIRAVATARS
Q8N201 S495 Sugiyama INTS1 KIAA1440 UNQ1821/PRO3434 KFLAMVFQDLLTNKDDYLRAsRALLREIIKQTKHEINFQAF
Q8N8S7 S125 Sugiyama ENAH MENA MHALEVLNSQETGPTLPRQNsQLPAQVQNGPSQEELEIQRR
Q8NBJ5 S612 Sugiyama COLGALT1 GLT25D1 PSEC0241 QKMREQQALSREAKNsDVLQsPLDsAARDEL__________
Q8NBJ5 S616 Sugiyama COLGALT1 GLT25D1 PSEC0241 EQQALSREAKNsDVLQsPLDsAARDEL______________
Q8NBJ7 S44 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 NGQATSMVQLQGGRFLMGtNsPDSRDGDGPVREATVKPFAI
Q8NBJ7 T272 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 LRGAsWIDtADGsANHRARVttRMGNtPDsAsDNLGFRCAA
Q8NBJ7 T273 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 RGAsWIDtADGsANHRARVttRMGNtPDsAsDNLGFRCAAD
Q8NBJ7 T278 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 IDtADGsANHRARVttRMGNtPDsAsDNLGFRCAADAGRPP
Q8NBS9 S285 Sugiyama TXNDC5 TLP46 UNQ364/PRO700 LLWFRDGKKVDQYKGKRDLEsLREyVEsQLQRTETGATETV
Q8NBS9 S292 Sugiyama TXNDC5 TLP46 UNQ364/PRO700 KKVDQYKGKRDLEsLREyVEsQLQRTETGATETVTPSEAPV
Q8NBS9 S426 Sugiyama TXNDC5 TLP46 UNQ364/PRO700 KKVSEHSGGRDLDSLHRFVLsQAKDEL______________
Q8TC07 S675 Sugiyama TBC1D15 TSAFQSNALPTLSASGARNDsPtQIPVssDVCRLtPA____
Q8TDD1 S624 Sugiyama DDX54 FQQGQQGRQEQQEGPVGPAPsRPALQEKQPEKEEEEEAGEs
Q8TEW0 S962 Sugiyama PARD3 PAR3 PAR3A DEGMEtLEEDTEESSRsGREsVstAsDQPsHsLERQMNGNQ
Q8WUX9 S410 Sugiyama CHMP7 DTTKEPLDLPDNPRNRHFtNsVPNPRIsDAELEAELEKLsL
Q8WUX9 T408 Sugiyama CHMP7 LQDTTKEPLDLPDNPRNRHFtNsVPNPRIsDAELEAELEKL
Q8WVV9 S75 Sugiyama HNRNPLL HNRPLL SRRF BLOCK24 GGGRsFsQPEAGGsHHKVsVsPVVHVRGLCEsVVEADLVEA
Q8WWM7 S111 Sugiyama ATXN2L A2D A2LG A2LP A2RP PGAAAIGsARGQstGKGPPQsPVFEGVyNNSRMLHFLTAVV
Q8WZA9 S44 Sugiyama IRGQ IRGQ1 FKSG27 IAALCDKDVEtLEAPEGRPDsGVPSLRAAGPGLFLGELSCP
Q92499 S481 Sugiyama DDX1 KSHIRTDDVHAKDNTRPGANsPEMWSEAIKILKGEYAVRAI
Q92785 S151 Sugiyama DPF2 BAF45D REQ UBID4 RGAPDPRVDDDsLGEFPVTNsRARKRILEPDDFLDDLDDED
Q92879 S179 Sugiyama CELF1 BRUNOL2 CUGBP CUGBP1 NAB50 AMAQTAIKAMHQAQtMEGCssPMVVKFADTQKDKEQKRMAQ
Q93100 S700 Sugiyama PHKB PEFKSFEELEPPKHSKVKRQsstPsAPELGQQPDVNISEWK
Q93100 S701 Sugiyama PHKB EFKSFEELEPPKHSKVKRQsstPsAPELGQQPDVNISEWKD
Q96B36 T246 EPSD|PSP AKT1S1 PRAS40 VLREAEDtQVFGDLPRPRLNtsDFQKLKRKY__________
Q96C19 S74 Sugiyama EFHD2 SWS1 ELSAKLLRRADLNQGIGEPQsPsRRVFNPytEFKEFSRKQI
Q96D46 S462 Sugiyama NMD3 CGI-07 FLEDLEEDEAIRKNVNIyRDsAIPVEsDtDDEGAPRISLAE
Q96EB6 T530 GPS6|EPSD SIRT1 SIR2L1 ITEKPPRTQKELAYLSELPPtPLHVsEDsssPERtsPPDss
Q96GM8 S428 Sugiyama TOE1 KAARPEIADRATsEVPGsQAsPNPVPGDGLHRAGFDAFMTG
Q96QK1 S783 Sugiyama VPS35 MEM3 TCCCTA00141 tEQINKHFHNtLEHLRLRREsPEsEGPIyEGLIL_______
Q96QK1 S786 Sugiyama VPS35 MEM3 TCCCTA00141 INKHFHNtLEHLRLRREsPEsEGPIyEGLIL__________
Q96S44 T8 Sugiyama TP53RK C20orf64 PRPK _____________MAAARAttPADGEEPAPEAEALAAARER
Q96T37 S670 Sugiyama RBM15 OTT OTT1 GRHLDRsPEsDRPRKRHCAPsPDRsPELsssRDRYNsDNDR
Q99426 S163 Sugiyama TBCB CG22 CKAP1 AEAAQRLAEEKAQASSIPVGsRCEVRAAGQSPRRGTVMYVG
Q99598 S33 Sugiyama TSNAX TRAX RKHDNFPHNQRREGKDVNsssPVMLAFKSFQQELDARHDKY
Q9BQ39 S140 Sugiyama DDX50 KSSDNKLEETLTREQKEGAFsNFPIsEEtIKLLKGRGVTYL
Q9BWH6 S80 Sugiyama RPAP1 KIAA1403 DNLPDLPPALVPsPPKRARPsPGHCLPEDEDPEERLRRHDQ
Q9BY44 S506 Sugiyama EIF2A CDA02 MSTP004 MSTP089 KNQRKHEAKKAAKQEARsDKsPDLAPtPAPQstPRNtVsQs
Q9BY44 T512 Sugiyama EIF2A CDA02 MSTP004 MSTP089 EAKKAAKQEARsDKsPDLAPtPAPQstPRNtVsQsIsGDPE
Q9BYG3 T234 Sugiyama NIFK MKI67IP NOPP34 KKKVsGtLDtPEKtVDsQGPtPVCtPtFLERRKsQVAELND
Q9BYG3 T238 Sugiyama NIFK MKI67IP NOPP34 sGtLDtPEKtVDsQGPtPVCtPtFLERRKsQVAELNDDDKD
Q9BZE9 S500 Sugiyama ASPSCR1 ASPL RCC17 TUG UBXD9 UBXN9 AISPSAADVLVARYMSRAAGsPsPLPAPDPAPKSEPAAEEG
Q9BZE9 S502 Sugiyama ASPSCR1 ASPL RCC17 TUG UBXD9 UBXN9 SPSAADVLVARYMSRAAGsPsPLPAPDPAPKSEPAAEEGAL
Q9C0C2 S1616 Sugiyama TNKS1BP1 KIAA1741 TAB182 LSEAADsDAHLFQDSTEPRAsRVPssDEEVVEEPQsRRTRM
Q9C0C2 S435 Sugiyama TNKS1BP1 KIAA1741 TAB182 DAHLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAALPQGQG
Q9C0C2 S494 Sugiyama TNKS1BP1 KIAA1741 TAB182 QSFEWTFPTRPSGLGVWRLDsPPPsPItEAsEAAEAAEAGN
Q9C0C2 S498 Sugiyama TNKS1BP1 KIAA1741 TAB182 WTFPTRPSGLGVWRLDsPPPsPItEAsEAAEAAEAGNLAVS
Q9C0C2 S672 Sugiyama TNKS1BP1 KIAA1741 TAB182 TLARAETtQARtEAQDLCRAsPEPPGPEsSSRWLDDLLAsP
Q9C0C2 S712 Sugiyama TNKS1BP1 KIAA1741 TAB182 PPPsGGGARRGAGAELKDtQsPstCsEGLLGWsQKDLQSEF
Q9C0C2 S983 Sugiyama TNKS1BP1 KIAA1741 TAB182 sGGsSRtLDAQDRsFGtRPLssGFsPEEAQQQDEEFEKKIP
Q9C0C2 S984 Sugiyama TNKS1BP1 KIAA1741 TAB182 GGsSRtLDAQDRsFGtRPLssGFsPEEAQQQDEEFEKKIPs
Q9H2U1 S283 Sugiyama DHX36 DDX36 KIAA1488 MLEL1 RHAU QPRRIsAISVAERVAAERAEsCGSGNSTGYQIRLQSRLPRK
Q9H2U2 S317 Sugiyama PPA2 HSPC124 DSPFRCtQEEARsLVEsVsssPNKEsNEEEQVWHFLGK___
Q9H773 S24 Sugiyama DCTPP1 XTP3TPA CDA03 AGGEIRGDTGGEDTAAPGRFsFsPEPTLEDIRRLHAEFAAE
Q9H773 S26 Sugiyama DCTPP1 XTP3TPA CDA03 GEIRGDTGGEDTAAPGRFsFsPEPTLEDIRRLHAEFAAERD
Q9HA77 T546 Sugiyama CARS2 OK/SW-cl.10 CDTLRRGLTAHGINIKDRssttstWELLDQRTKDQKSAG__
Q9HA77 T547 Sugiyama CARS2 OK/SW-cl.10 DTLRRGLTAHGINIKDRssttstWELLDQRTKDQKSAG___
Q9HCN8 T70 Sugiyama SDF2L1 UNQ1941/PRO4424 RVRLHSHDIKYGSGSGQQSVtGVEAsDDANSyWRIRGGSEG
Q9HDC5 S413 Sugiyama JPH1 JP1 QAALAARQECDIARAVARELsPDFyQPGPDyVKQRFQEGVD
Q9NP61 S455 Sugiyama ARFGAP3 ARFGAP1 RQsQADYETRARLERLsAsssIssADLFEEPRKQPAGNysL
Q9NP81 S53 Sugiyama SARS2 SARSM SFTTEKRNRNLLYEYAREGysALPQLDIERFCACPEEAAHA
Q9NPD8 T44 Sugiyama UBE2T HSPC150 PIG50 CWQDKDQMDDLRAQILGGANtPYEKGVFKLEVIIPERYPFE
Q9NQ39 S157 Sugiyama RPS10P5 RPS10L TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9NR19 S28 Sugiyama ACSS2 ACAS2 VRsGsGSRGQEEAGAGGRARsWsPPPEVsRSAHVPSLQRYR
Q9NR19 S30 Sugiyama ACSS2 ACAS2 sGsGSRGQEEAGAGGRARsWsPPPEVsRSAHVPSLQRYREL
Q9NR28 S230 Sugiyama DIABLO SMAC EAQIEELRQKTQEEGEERAEsEQEAyLRED___________
Q9NR30 S189 Sugiyama DDX21 EEsNsEIEQEIPVEQKEGAFsNFPIsEEtIKLLKGRGVTFL
Q9NR30 S706 Sugiyama DDX21 PTASVTEIQEKWHDSRRWQLsVATEQPELEGPREGYGGFRG
Q9NRX4 S80 Sugiyama PHPT1 PHP14 CGI-202 HSPC141 VSGDMQKQGCDCECLGGGRIsHQSQDKKIHVyGysMAyGPA
Q9NTJ3 S41 Sugiyama SMC4 CAPC SMC4L1 PsPDGAssDAEPEPPsGRtEsPAtAAEtAsEELDNRSLEEI
Q9NTJ3 T44 Sugiyama SMC4 CAPC SMC4L1 DGAssDAEPEPPsGRtEsPAtAAEtAsEELDNRSLEEILNS
Q9NUQ3 S97 Sugiyama TXLNG CXorf15 ELRG LSR5 KHSLEEDEGsDFItENRNLVsPAyCtQEsREEIPGGEARTD
Q9NXH9 S524 Sugiyama TRMT1 KECPVKRERLsETsPAFRILsVEPRLQANFTIREDANPSSR
Q9NY33 S218 Sugiyama DPP3 tRLFKEVDGEGKPYYEVRLAsVLGSEPsLDsEVTSKLKSYE
Q9NY33 S228 Sugiyama DPP3 GKPYYEVRLAsVLGSEPsLDsEVTSKLKSYEFRGsPFQVTR
Q9UGV2 S333 Sugiyama NDRG3 MGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsD
Q9UGV2 S361 Sugiyama NDRG3 sPFsRsVtsNQsDGtQESCEsPDVLDRHQTMEVsC______
Q9UGV2 T332 Sugiyama NDRG3 GMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQs
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UII2 S63 Sugiyama ATP5IF1 ATPI ATPIF1 AGGAFGKREQAEEERyFRAQsREQLAALKKHHEEEIVHHKK
Q9UKN8 S812 Sugiyama GTF3C4 DSIARHPAPEDPDWIKRLLQsPCPFCDsPVF__________
Q9UKN8 S819 Sugiyama GTF3C4 APEDPDWIKRLLQsPCPFCDsPVF_________________
Q9UKT5 S12 Sugiyama FBXO4 FBX4 _________MAGSEPRsGtNsPPPPFSDWGRLEAAILSGWK
Q9UNN5 T580 Sugiyama FAF1 UBXD12 UBXN3A CGI-03 ALPPEPKEENAEPVSKLRIRtPsGEFLERRFLASNKLQIVF
Q9UNX3 S32 Sugiyama RPL26L1 RPL26P1 sKNRKRHFNAPSHVRRKIMssPLSKELRQKYNVRSMPIRKD
Q9UNZ2 S176 Sugiyama NSFL1C UBXN2C RLGAAPEEEsAyVAGEKRQHssQDVHVVLKLWKsGFsLDNG
Q9UNZ2 T73 Sugiyama NSFL1C UBXN2C ISQATPssVsRGTAPSDNRVtsFRDLIHDQDEDEEEEEGQR
Q9UPQ0 S185 Sugiyama LIMCH1 KIAA1102 DDIEsPKRSIRDsGyIDCWDsERsDsLsPPRHGRDDsFDsL
Q9UPQ0 S192 Sugiyama LIMCH1 KIAA1102 RSIRDsGyIDCWDsERsDsLsPPRHGRDDsFDsLDsFGsRs
Q9UPQ0 S217 Sugiyama LIMCH1 KIAA1102 GRDDsFDsLDsFGsRsRQtPsPDVVLRGssDGRGsDsEsDL
Q9UPQ0 T215 Sugiyama LIMCH1 KIAA1102 RHGRDDsFDsLDsFGsRsRQtPsPDVVLRGssDGRGsDsEs
Q9UQ35 S1103 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35 S1320 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sMASSWGGPHFsPEHKELsNsPLRENsFGsPLEFRNsGPLG
Q9UQ35 S1329 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 HFsPEHKELsNsPLRENsFGsPLEFRNsGPLGTEMNtGFss
Q9UQ35 S1541 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDs
Q9UQ35 S1552 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 PLGQRsRsGssQELDVKPsAsPQERsEsDssPDSKAKTRTP
Q9UQ35 S1648 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 APRALPRRSRSGSSSKGRGPsPEGssstEssPEHPPKSRTA
Q9UQ35 S2132 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9Y230 T360 Sugiyama RUVBL2 INO80J TIP48 TIP49B CGI-46 YQsPHGIPIDLLDRLLIVsTtPySEKDTKQILRIRCEEEDV
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2V2 S30 Sugiyama CARHSP1 QPPtHQAsVGLLDtPRsRERsPsPLRGNVVPsPLPtRRtRt
Q9Y2V2 S32 Sugiyama CARHSP1 PtHQAsVGLLDtPRsRERsPsPLRGNVVPsPLPtRRtRtFs
Q9Y2V2 S41 Sugiyama CARHSP1 LDtPRsRERsPsPLRGNVVPsPLPtRRtRtFsAtVRASQGP
Q9Y2W2 S237 Sugiyama WBP11 NPWBP SIPP1 SNP70 RKVGFALDLPPRRRDEDMLysPELAQRGHDDDVSSTSEDDG
Q9Y4F1 S510 Sugiyama FARP1 CDEP PLEKHC2 GVAPANVTLSPNLsPDTKQAsPLIsPLLNDQACPRtDDEDE
Q9Y4F1 S514 Sugiyama FARP1 CDEP PLEKHC2 ANVTLSPNLsPDTKQAsPLIsPLLNDQACPRtDDEDEGRRK
Q9Y5B9 S455 Sugiyama SUPT16H FACT140 FACTP140 EDEEEEEEEKDEAEDLLGRGsRAALLTERTRNEMTAEEKRR
Q9Y6Q9 S1330 SIGNOR|PSP NCOA3 AIB1 BHLHE42 RAC3 TRAM1 PYQPNYGMGQQPDPAFGRVssPPNAMMSSRMGPSQNPMMQH
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Chromatin organization R-HSA-4839726 5.356421e-10 9.271 0 0
Chromatin modifying enzymes R-HSA-3247509 1.212106e-09 8.916 0 0
Cell Cycle R-HSA-1640170 5.133250e-08 7.290 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.065113e-06 5.973 0 0
Cell Cycle, Mitotic R-HSA-69278 1.157675e-06 5.936 0 0
NRAGE signals death through JNK R-HSA-193648 1.019040e-05 4.992 0 0
Gene expression (Transcription) R-HSA-74160 1.059936e-05 4.975 0 0
Regulation of TP53 Activity R-HSA-5633007 1.461941e-05 4.835 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.330164e-05 4.633 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 4.044405e-05 4.393 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 5.781878e-05 4.238 0 0
G alpha (12/13) signalling events R-HSA-416482 6.204481e-05 4.207 0 0
RNA Polymerase II Transcription R-HSA-73857 8.069273e-05 4.093 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.390552e-04 3.857 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.466955e-04 3.834 0 0
RUNX2 regulates bone development R-HSA-8941326 3.098686e-04 3.509 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.981889e-04 3.526 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 3.228154e-04 3.491 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.353792e-04 3.474 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 3.676544e-04 3.435 0 0
Signal Transduction R-HSA-162582 4.250270e-04 3.372 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 5.671398e-04 3.246 0 0
HATs acetylate histones R-HSA-3214847 5.933105e-04 3.227 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 6.632138e-04 3.178 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 6.916860e-04 3.160 0 0
Epigenetic regulation of gene expression R-HSA-212165 7.168854e-04 3.145 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 8.052235e-04 3.094 0 0
Cell Cycle Checkpoints R-HSA-69620 8.078882e-04 3.093 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 7.939605e-04 3.100 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 8.274455e-04 3.082 0 0
G1/S-Specific Transcription R-HSA-69205 8.934377e-04 3.049 0 0
Cardiogenesis R-HSA-9733709 9.996097e-04 3.000 0 0
Polo-like kinase mediated events R-HSA-156711 1.290380e-03 2.889 0 0
M Phase R-HSA-68886 1.471161e-03 2.832 0 0
mRNA 3'-end processing R-HSA-72187 1.573972e-03 2.803 0 0
Generic Transcription Pathway R-HSA-212436 1.597461e-03 2.797 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.092673e-03 2.679 0 0
mRNA Splicing R-HSA-72172 2.137948e-03 2.670 0 0
Circadian clock R-HSA-9909396 2.116275e-03 2.674 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.173327e-03 2.663 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.309845e-03 2.636 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.367741e-03 2.626 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.427819e-03 2.615 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.698881e-03 2.569 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.792834e-03 2.554 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.967370e-03 2.528 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 3.445090e-03 2.463 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 4.004818e-03 2.397 0 0
S Phase R-HSA-69242 3.986284e-03 2.399 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 4.004818e-03 2.397 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.031177e-03 2.395 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 4.366954e-03 2.360 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 4.351705e-03 2.361 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 4.351705e-03 2.361 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 4.533047e-03 2.344 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 4.611910e-03 2.336 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 4.791994e-03 2.319 0 0
Notch-HLH transcription pathway R-HSA-350054 5.139276e-03 2.289 0 0
Mitotic Prophase R-HSA-68875 5.265534e-03 2.279 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 6.043351e-03 2.219 0 0
Estrogen-dependent gene expression R-HSA-9018519 6.089027e-03 2.215 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.164581e-03 2.210 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 6.164581e-03 2.210 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 6.497143e-03 2.187 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.004893e-03 2.155 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 7.286105e-03 2.138 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 7.937659e-03 2.100 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 7.937659e-03 2.100 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 7.937659e-03 2.100 0 0
Nuclear Envelope Breakdown R-HSA-2980766 7.849315e-03 2.105 0 0
G2/M Transition R-HSA-69275 8.424473e-03 2.074 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 9.091766e-03 2.041 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 9.091766e-03 2.041 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 9.091766e-03 2.041 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 9.091766e-03 2.041 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.003362e-02 1.999 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.003362e-02 1.999 0 0
HDMs demethylate histones R-HSA-3214842 1.003362e-02 1.999 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 9.837966e-03 2.007 0 0
Mitotic G2-G2/M phases R-HSA-453274 9.770010e-03 2.010 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.039480e-02 1.983 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.042511e-02 1.982 0 0
Death Receptor Signaling R-HSA-73887 1.109402e-02 1.955 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.179485e-02 1.928 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.179485e-02 1.928 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.159764e-02 1.936 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.166281e-02 1.933 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.138540e-02 1.944 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.166281e-02 1.933 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.324122e-02 1.878 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.324122e-02 1.878 0 0
Cellular Senescence R-HSA-2559583 1.337226e-02 1.874 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 1.519073e-02 1.818 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.514377e-02 1.820 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.442690e-02 1.841 0 0
G0 and Early G1 R-HSA-1538133 1.492046e-02 1.826 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.492046e-02 1.826 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.516358e-02 1.819 0 0
Deubiquitination R-HSA-5688426 1.390040e-02 1.857 0 0
NrCAM interactions R-HSA-447038 1.519073e-02 1.818 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.492046e-02 1.826 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.538467e-02 1.813 0 0
G1/S Transition R-HSA-69206 1.568599e-02 1.804 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.706655e-02 1.768 0 0
Type I hemidesmosome assembly R-HSA-446107 1.707059e-02 1.768 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 1.657816e-02 1.780 0 0
Adipogenesis R-HSA-9843745 1.698196e-02 1.770 0 0
Specification of the neural plate border R-HSA-9834899 1.683117e-02 1.774 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.767395e-02 1.753 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.939991e-02 1.712 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.084122e-02 1.681 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.084122e-02 1.681 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.135965e-02 1.670 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.068340e-02 1.684 0 0
NGF-stimulated transcription R-HSA-9031628 2.080988e-02 1.682 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.005732e-02 1.698 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.078244e-02 1.682 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 2.189214e-02 1.660 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 2.338448e-02 1.631 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 2.338448e-02 1.631 0 0
RAF activation R-HSA-5673000 2.428955e-02 1.615 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.327103e-02 1.633 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.385525e-02 1.622 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.327103e-02 1.633 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.323006e-02 1.634 0 0
Nuclear import of Rev protein R-HSA-180746 2.428955e-02 1.615 0 0
Disorders of Developmental Biology R-HSA-9675151 2.442828e-02 1.612 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.442828e-02 1.612 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.512960e-02 1.600 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.512960e-02 1.600 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.560309e-02 1.592 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.573731e-02 1.589 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.986386e-02 1.525 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.986386e-02 1.525 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.986386e-02 1.525 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 3.025700e-02 1.519 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 3.025700e-02 1.519 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 3.182485e-02 1.497 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.824903e-02 1.549 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 3.028477e-02 1.519 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.946627e-02 1.531 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.946627e-02 1.531 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.994079e-02 1.524 0 0
G2/M DNA damage checkpoint R-HSA-69473 3.050796e-02 1.516 0 0
Mitotic Anaphase R-HSA-68882 2.847597e-02 1.546 0 0
Mitotic Prometaphase R-HSA-68877 3.138077e-02 1.503 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.015977e-02 1.521 0 0
RET signaling R-HSA-8853659 3.254415e-02 1.488 0 0
Semaphorin interactions R-HSA-373755 3.250138e-02 1.488 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.864474e-02 1.543 0 0
Specification of primordial germ cells R-HSA-9827857 3.028477e-02 1.519 0 0
Gastrulation R-HSA-9758941 3.007263e-02 1.522 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 3.156328e-02 1.501 0 0
Heme signaling R-HSA-9707616 2.916838e-02 1.535 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.381909e-02 1.471 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.412358e-02 1.467 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 3.571512e-02 1.447 0 0
Regulation of KIT signaling R-HSA-1433559 3.571512e-02 1.447 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 3.669278e-02 1.435 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 3.701782e-02 1.432 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 3.734182e-02 1.428 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.967767e-02 1.401 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.967767e-02 1.401 0 0
Nuclear RNA decay R-HSA-9930044 3.967767e-02 1.401 0 0
Formation of the posterior neural plate R-HSA-9832991 4.148296e-02 1.382 0 0
AURKA Activation by TPX2 R-HSA-8854518 4.416908e-02 1.355 0 0
Formation of the anterior neural plate R-HSA-9823739 4.434195e-02 1.353 0 0
Cell-extracellular matrix interactions R-HSA-446353 4.434195e-02 1.353 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 4.141688e-02 1.383 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 4.261298e-02 1.370 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.453770e-02 1.351 0 0
Germ layer formation at gastrulation R-HSA-9754189 4.466739e-02 1.350 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 4.559829e-02 1.341 0 0
MECP2 regulates transcription factors R-HSA-9022707 4.656547e-02 1.332 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 4.656547e-02 1.332 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 4.656547e-02 1.332 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 4.656547e-02 1.332 0 0
G2/M Checkpoints R-HSA-69481 4.659829e-02 1.332 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 4.749406e-02 1.323 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.749406e-02 1.323 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.749406e-02 1.323 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 4.817786e-02 1.317 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.837512e-02 1.315 0 0
Oncogenic MAPK signaling R-HSA-6802957 4.853534e-02 1.314 0 0
Signaling by AXIN mutants R-HSA-4839735 5.273149e-02 1.278 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 5.326431e-02 1.274 0 0
DNA Double Strand Break Response R-HSA-5693606 4.864797e-02 1.313 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 5.396334e-02 1.268 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 5.464361e-02 1.262 0 0
Signaling by ALK in cancer R-HSA-9700206 5.396334e-02 1.268 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 5.208826e-02 1.283 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 4.929174e-02 1.307 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 5.464361e-02 1.262 0 0
Homology Directed Repair R-HSA-5693538 5.568297e-02 1.254 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.577721e-02 1.254 0 0
Nervous system development R-HSA-9675108 5.828282e-02 1.234 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 5.854594e-02 1.233 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 5.854594e-02 1.233 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 5.916336e-02 1.228 0 0
TGFBR3 expression R-HSA-9839394 5.953497e-02 1.225 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 6.143141e-02 1.212 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 6.143141e-02 1.212 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 6.162547e-02 1.210 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 6.162547e-02 1.210 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 6.162547e-02 1.210 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 6.162547e-02 1.210 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 6.856071e-02 1.164 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 6.856071e-02 1.164 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 6.558525e-02 1.183 0 0
Repression of WNT target genes R-HSA-4641265 6.558525e-02 1.183 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 6.520512e-02 1.186 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 6.869858e-02 1.163 0 0
Axon guidance R-HSA-422475 6.715961e-02 1.173 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 6.520512e-02 1.186 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 7.072148e-02 1.150 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 6.558525e-02 1.183 0 0
Signaling by NTRKs R-HSA-166520 6.343864e-02 1.198 0 0
Apoptotic execution phase R-HSA-75153 6.291109e-02 1.201 0 0
Ovarian tumor domain proteases R-HSA-5689896 7.511555e-02 1.124 0 0
TCF dependent signaling in response to WNT R-HSA-201681 7.612162e-02 1.118 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 7.725105e-02 1.112 0 0
Signaling by Hippo R-HSA-2028269 7.746504e-02 1.111 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 7.894023e-02 1.103 0 0
Protein-protein interactions at synapses R-HSA-6794362 7.949766e-02 1.100 0 0
Formation of axial mesoderm R-HSA-9796292 8.003058e-02 1.097 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 8.202944e-02 1.086 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 8.490147e-02 1.071 0 0
Signaling by SCF-KIT R-HSA-1433557 8.500215e-02 1.071 0 0
HDACs deacetylate histones R-HSA-3214815 8.502904e-02 1.070 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 8.563973e-02 1.067 0 0
Amplification of signal from the kinetochores R-HSA-141424 8.563973e-02 1.067 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.006080e-01 0.997 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.006080e-01 0.997 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.006080e-01 0.997 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.006080e-01 0.997 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.006080e-01 0.997 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.006080e-01 0.997 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.006080e-01 0.997 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.006080e-01 0.997 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.006080e-01 0.997 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.006080e-01 0.997 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.006080e-01 0.997 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 9.310630e-02 1.031 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 9.310630e-02 1.031 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 9.602756e-02 1.018 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 9.215398e-02 1.035 0 0
Processing of DNA double-strand break ends R-HSA-5693607 9.417329e-02 1.026 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.238452e-02 1.034 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.238452e-02 1.034 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.238452e-02 1.034 0 0
Chaperone Mediated Autophagy R-HSA-9613829 9.093339e-02 1.041 0 0
G1 Phase R-HSA-69236 9.394507e-02 1.027 0 0
Cyclin D associated events in G1 R-HSA-69231 9.394507e-02 1.027 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 9.299313e-02 1.032 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 8.665831e-02 1.062 0 0
Regulation of TP53 Expression R-HSA-6804754 1.006080e-01 0.997 0 0
Intracellular signaling by second messengers R-HSA-9006925 9.319069e-02 1.031 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 8.906269e-02 1.050 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 9.390745e-02 1.027 0 0
Ub-specific processing proteases R-HSA-5689880 8.957719e-02 1.048 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 9.551255e-02 1.020 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 9.093339e-02 1.041 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 9.839985e-02 1.007 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 1.036312e-01 0.985 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 1.036312e-01 0.985 0 0
Signaling by NOTCH1 R-HSA-1980143 1.036717e-01 0.984 0 0
Drug resistance of FLT3 mutants R-HSA-9702506 1.249354e-01 0.903 0 0
FLT3 mutants bind TKIs R-HSA-9702509 1.249354e-01 0.903 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.249354e-01 0.903 0 0
KW2449-resistant FLT3 mutants R-HSA-9702569 1.249354e-01 0.903 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.249354e-01 0.903 0 0
ponatinib-resistant FLT3 mutants R-HSA-9702614 1.249354e-01 0.903 0 0
linifanib-resistant FLT3 mutants R-HSA-9702998 1.249354e-01 0.903 0 0
Deletions in the AXIN1 gene destabilize the destruction complex R-HSA-5467345 1.249354e-01 0.903 0 0
lestaurtinib-resistant FLT3 mutants R-HSA-9702596 1.249354e-01 0.903 0 0
tandutinib-resistant FLT3 mutants R-HSA-9702636 1.249354e-01 0.903 0 0
sunitinib-resistant FLT3 mutants R-HSA-9702632 1.249354e-01 0.903 0 0
midostaurin-resistant FLT3 mutants R-HSA-9702600 1.249354e-01 0.903 0 0
semaxanib-resistant FLT3 mutants R-HSA-9702577 1.249354e-01 0.903 0 0
tamatinib-resistant FLT3 mutants R-HSA-9703009 1.249354e-01 0.903 0 0
gilteritinib-resistant FLT3 mutants R-HSA-9702590 1.249354e-01 0.903 0 0
quizartinib-resistant FLT3 mutants R-HSA-9702620 1.249354e-01 0.903 0 0
sorafenib-resistant FLT3 mutants R-HSA-9702624 1.249354e-01 0.903 0 0
pexidartinib-resistant FLT3 mutants R-HSA-9702605 1.249354e-01 0.903 0 0
crenolanib-resistant FLT3 mutants R-HSA-9702581 1.249354e-01 0.903 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.444926e-01 0.840 0 0
MET interacts with TNS proteins R-HSA-8875513 1.444926e-01 0.840 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 1.444926e-01 0.840 0 0
MET activates PTPN11 R-HSA-8865999 1.444926e-01 0.840 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.206988e-01 0.918 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 1.206988e-01 0.918 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 1.508644e-01 0.821 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.508644e-01 0.821 0 0
Regulation of PTEN localization R-HSA-8948747 1.508644e-01 0.821 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 1.508644e-01 0.821 0 0
SOS-mediated signalling R-HSA-112412 1.508644e-01 0.821 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 1.198532e-01 0.921 0 0
Signaling by APC mutants R-HSA-4839744 1.198532e-01 0.921 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.198532e-01 0.921 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.198532e-01 0.921 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.198532e-01 0.921 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.431176e-01 0.844 0 0
Activation of RAC1 R-HSA-428540 1.431176e-01 0.844 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.431176e-01 0.844 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.055837e-01 0.976 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 1.324022e-01 0.878 0 0
Differentiation of T cells R-HSA-9945266 1.324022e-01 0.878 0 0
Negative regulation of FLT3 R-HSA-9706369 1.324022e-01 0.878 0 0
Phosphorylation of the APC/C R-HSA-176412 1.324022e-01 0.878 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.213761e-01 0.916 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.213761e-01 0.916 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.213761e-01 0.916 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.213761e-01 0.916 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.134609e-01 0.945 0 0
Metabolism of non-coding RNA R-HSA-194441 1.195476e-01 0.922 0 0
snRNP Assembly R-HSA-191859 1.195476e-01 0.922 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.319206e-01 0.880 0 0
Centrosome maturation R-HSA-380287 1.510278e-01 0.821 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.285156e-01 0.891 0 0
Cellular response to heat stress R-HSA-3371556 1.448760e-01 0.839 0 0
Separation of Sister Chromatids R-HSA-2467813 1.054308e-01 0.977 0 0
Formation of definitive endoderm R-HSA-9823730 1.213761e-01 0.916 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.135125e-01 0.945 0 0
Neurexins and neuroligins R-HSA-6794361 1.120403e-01 0.951 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.406716e-01 0.852 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.370422e-01 0.863 0 0
FOXO-mediated transcription R-HSA-9614085 1.069454e-01 0.971 0 0
FLT3 signaling in disease R-HSA-9682385 1.266849e-01 0.897 0 0
DCC mediated attractive signaling R-HSA-418885 1.135127e-01 0.945 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.553603e-01 0.809 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.395387e-01 0.855 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 1.525949e-01 0.816 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.557591e-01 0.808 0 0
Signaling by WNT in cancer R-HSA-4791275 1.406716e-01 0.852 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.229106e-01 0.910 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.240011e-01 0.907 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.448760e-01 0.839 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.405147e-01 0.852 0 0
Long-term potentiation R-HSA-9620244 1.252382e-01 0.902 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.405147e-01 0.852 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 1.500198e-01 0.824 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.553603e-01 0.809 0 0
DNA Repair R-HSA-73894 1.078680e-01 0.967 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.292776e-01 0.888 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.292776e-01 0.888 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.292776e-01 0.888 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.292776e-01 0.888 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.261274e-01 0.899 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.530320e-01 0.815 0 0
Signaling by TGFB family members R-HSA-9006936 1.200314e-01 0.921 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 1.206988e-01 0.918 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.431176e-01 0.844 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.431176e-01 0.844 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.525949e-01 0.816 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.234136e-01 0.909 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.292776e-01 0.888 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.525949e-01 0.816 0 0
tRNA processing in the nucleus R-HSA-6784531 1.500198e-01 0.824 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.510278e-01 0.821 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.561664e-01 0.806 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.561664e-01 0.806 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.561664e-01 0.806 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.610139e-01 0.793 0 0
RMTs methylate histone arginines R-HSA-3214858 1.630979e-01 0.788 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.342682e-01 0.630 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.342682e-01 0.630 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.342682e-01 0.630 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.342682e-01 0.630 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.342682e-01 0.630 0 0
Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) R-HSA-9036092 2.342682e-01 0.630 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.342682e-01 0.630 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.342682e-01 0.630 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.342682e-01 0.630 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.914535e-01 0.718 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.914535e-01 0.718 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.914535e-01 0.718 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 1.914535e-01 0.718 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 1.914535e-01 0.718 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 1.914535e-01 0.718 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 1.914535e-01 0.718 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 1.914535e-01 0.718 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 3.299463e-01 0.482 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 3.299463e-01 0.482 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.299463e-01 0.482 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 3.299463e-01 0.482 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 3.299463e-01 0.482 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 3.299463e-01 0.482 0 0
XAV939 stabilizes AXIN R-HSA-5545619 3.299463e-01 0.482 0 0
Defective VWF binding to collagen type I R-HSA-9845622 3.299463e-01 0.482 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.299463e-01 0.482 0 0
Intestinal infectious diseases R-HSA-8942233 3.299463e-01 0.482 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 3.299463e-01 0.482 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.299463e-01 0.482 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.299463e-01 0.482 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.299463e-01 0.482 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.299463e-01 0.482 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.400378e-01 0.620 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.400378e-01 0.620 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.400378e-01 0.620 0 0
IRS activation R-HSA-74713 2.400378e-01 0.620 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.400378e-01 0.620 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 2.400378e-01 0.620 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.400378e-01 0.620 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 2.400378e-01 0.620 0 0
MET receptor recycling R-HSA-8875656 1.831161e-01 0.737 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 1.831161e-01 0.737 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 1.679878e-01 0.775 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.679878e-01 0.775 0 0
Disorders of Nervous System Development R-HSA-9697154 1.679878e-01 0.775 0 0
Pervasive developmental disorders R-HSA-9005895 1.679878e-01 0.775 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.679878e-01 0.775 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.679878e-01 0.775 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.679878e-01 0.775 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.679878e-01 0.775 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.679878e-01 0.775 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.679878e-01 0.775 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.169755e-01 0.664 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.169755e-01 0.664 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.891076e-01 0.539 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.891076e-01 0.539 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 2.891076e-01 0.539 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.891076e-01 0.539 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.136743e-01 0.383 0 0
Potassium transport channels R-HSA-1296067 4.136743e-01 0.383 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.136743e-01 0.383 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 4.136743e-01 0.383 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 4.136743e-01 0.383 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 4.136743e-01 0.383 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 1.942440e-01 0.712 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.942440e-01 0.712 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.942440e-01 0.712 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.942440e-01 0.712 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 2.519867e-01 0.599 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 2.519867e-01 0.599 0 0
STAT5 Activation R-HSA-9645135 3.377835e-01 0.471 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 3.377835e-01 0.471 0 0
G2/M DNA replication checkpoint R-HSA-69478 3.377835e-01 0.471 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.377835e-01 0.471 0 0
ChREBP activates metabolic gene expression R-HSA-163765 2.877268e-01 0.541 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 2.877268e-01 0.541 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.500043e-01 0.602 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.197948e-01 0.658 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.197948e-01 0.658 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.912489e-01 0.718 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 3.238112e-01 0.490 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 3.238112e-01 0.490 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 3.853984e-01 0.414 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 3.853984e-01 0.414 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.853984e-01 0.414 0 0
TRIF-mediated programmed cell death R-HSA-2562578 3.853984e-01 0.414 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 3.853984e-01 0.414 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 3.853984e-01 0.414 0 0
Disinhibition of SNARE formation R-HSA-114516 3.853984e-01 0.414 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.869442e-01 0.313 0 0
Defective GSS causes GSS deficiency R-HSA-5579006 4.869442e-01 0.313 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 4.869442e-01 0.313 0 0
Invadopodia formation R-HSA-8941237 4.869442e-01 0.313 0 0
Activation of the pre-replicative complex R-HSA-68962 2.096126e-01 0.679 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.365063e-01 0.626 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.687827e-01 0.571 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 2.687827e-01 0.571 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 3.085948e-01 0.511 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 2.583271e-01 0.588 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.598971e-01 0.444 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.907212e-01 0.720 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.907212e-01 0.720 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.844597e-01 0.734 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 3.384172e-01 0.471 0 0
Regulation by c-FLIP R-HSA-3371378 4.314576e-01 0.365 0 0
Dimerization of procaspase-8 R-HSA-69416 4.314576e-01 0.365 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.979545e-01 0.703 0 0
Meiotic synapsis R-HSA-1221632 1.979545e-01 0.703 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.681699e-01 0.572 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 3.198309e-01 0.495 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.841905e-01 0.735 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 3.033901e-01 0.518 0 0
Formation of the Early Elongation Complex R-HSA-113418 3.033901e-01 0.518 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.683299e-01 0.434 0 0
PKA activation in glucagon signalling R-HSA-164378 3.683299e-01 0.434 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.457896e-01 0.461 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.264403e-01 0.486 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 3.094004e-01 0.509 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 2.941314e-01 0.531 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.497106e-01 0.456 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.497106e-01 0.456 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.718673e-01 0.430 0 0
E2F mediated regulation of DNA replication R-HSA-113510 3.981553e-01 0.400 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 4.309145e-01 0.366 0 0
Lipophagy R-HSA-9613354 4.756067e-01 0.323 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.756067e-01 0.323 0 0
CASP8 activity is inhibited R-HSA-5218900 4.756067e-01 0.323 0 0
ALK mutants bind TKIs R-HSA-9700645 4.756067e-01 0.323 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.510616e-01 0.259 0 0
HCN channels R-HSA-1296061 5.510616e-01 0.259 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.510616e-01 0.259 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 5.510616e-01 0.259 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 5.510616e-01 0.259 0 0
Signaling by MAP2K mutants R-HSA-9652169 5.510616e-01 0.259 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.310004e-01 0.636 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.007682e-01 0.522 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 3.328822e-01 0.478 0 0
Signaling by RAF1 mutants R-HSA-9656223 3.328822e-01 0.478 0 0
HIV Transcription Initiation R-HSA-167161 3.328822e-01 0.478 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 3.328822e-01 0.478 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 3.517191e-01 0.454 0 0
Negative regulation of MET activity R-HSA-6807004 4.277324e-01 0.369 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 2.920655e-01 0.535 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 4.653700e-01 0.332 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 4.653700e-01 0.332 0 0
Erythropoietin activates RAS R-HSA-9027284 4.653700e-01 0.332 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 4.653700e-01 0.332 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 4.653700e-01 0.332 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 4.653700e-01 0.332 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.694435e-01 0.570 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 3.723783e-01 0.429 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 5.176039e-01 0.286 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.496551e-01 0.347 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 4.496551e-01 0.347 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 4.496551e-01 0.347 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 4.496551e-01 0.347 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 4.121843e-01 0.385 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 4.988708e-01 0.302 0 0
Translesion synthesis by POLI R-HSA-5656121 4.988708e-01 0.302 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.374120e-01 0.359 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 4.320734e-01 0.364 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.271155e-01 0.369 0 0
HIV elongation arrest and recovery R-HSA-167287 4.750904e-01 0.323 0 0
Pausing and recovery of HIV elongation R-HSA-167290 4.750904e-01 0.323 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 4.586809e-01 0.338 0 0
MAP2K and MAPK activation R-HSA-5674135 4.797717e-01 0.319 0 0
FGFR2 alternative splicing R-HSA-6803529 5.136117e-01 0.289 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 5.312718e-01 0.275 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 5.312718e-01 0.275 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 5.572976e-01 0.254 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 6.071694e-01 0.217 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 6.071694e-01 0.217 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 6.071694e-01 0.217 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 6.071694e-01 0.217 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 4.401572e-01 0.356 0 0
PRC2 methylates histones and DNA R-HSA-212300 5.116230e-01 0.291 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 5.409169e-01 0.267 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 4.884720e-01 0.311 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 4.884720e-01 0.311 0 0
HSF1-dependent transactivation R-HSA-3371571 5.295091e-01 0.276 0 0
MET promotes cell motility R-HSA-8875878 5.554136e-01 0.255 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 5.674159e-01 0.246 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.946076e-01 0.226 0 0
ERKs are inactivated R-HSA-202670 5.946076e-01 0.226 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 5.717893e-01 0.243 0 0
PKA activation R-HSA-163615 5.923506e-01 0.227 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 5.923506e-01 0.227 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 5.808729e-01 0.236 0 0
Translation initiation complex formation R-HSA-72649 5.849333e-01 0.233 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 5.930438e-01 0.227 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 5.925378e-01 0.227 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 5.999412e-01 0.222 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 6.200863e-01 0.208 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 6.174242e-01 0.209 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 6.208843e-01 0.207 0 0
MET activates RAS signaling R-HSA-8851805 6.295098e-01 0.201 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 6.295098e-01 0.201 0 0
Polymerase switching R-HSA-69091 6.295098e-01 0.201 0 0
Leading Strand Synthesis R-HSA-69109 6.295098e-01 0.201 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.562678e-01 0.183 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.562678e-01 0.183 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 6.562678e-01 0.183 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.562678e-01 0.183 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.562678e-01 0.183 0 0
PKB-mediated events R-HSA-109703 6.562678e-01 0.183 0 0
Phosphorylation of Emi1 R-HSA-176417 6.562678e-01 0.183 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 6.562678e-01 0.183 0 0
PDE3B signalling R-HSA-165160 6.562678e-01 0.183 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.562678e-01 0.183 0 0
Interaction between L1 and Ankyrins R-HSA-445095 6.414931e-01 0.193 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 6.414931e-01 0.193 0 0
Regulation of RAS by GAPs R-HSA-5658442 6.542973e-01 0.184 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 6.480239e-01 0.188 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.480239e-01 0.188 0 0
PTEN Regulation R-HSA-6807070 2.050168e-01 0.688 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.028283e-01 0.693 0 0
Transcription of the HIV genome R-HSA-167172 3.193022e-01 0.496 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 4.586809e-01 0.338 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.483467e-01 0.605 0 0
EGFR downregulation R-HSA-182971 5.487129e-01 0.261 0 0
Signaling by NOTCH3 R-HSA-9012852 4.642620e-01 0.333 0 0
Nucleotide Excision Repair R-HSA-5696398 4.947801e-01 0.306 0 0
HIV Transcription Elongation R-HSA-167169 4.374120e-01 0.359 0 0
FLT3 Signaling R-HSA-9607240 1.970775e-01 0.705 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 4.847135e-01 0.315 0 0
Regulation of mitotic cell cycle R-HSA-453276 4.847135e-01 0.315 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.855799e-01 0.314 0 0
Signaling by MET R-HSA-6806834 6.258835e-01 0.204 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.956843e-01 0.403 0 0
Signaling by ERBB2 R-HSA-1227986 4.224708e-01 0.374 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.903502e-01 0.537 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.277324e-01 0.369 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 5.701771e-01 0.244 0 0
Termination of translesion DNA synthesis R-HSA-5656169 5.001281e-01 0.301 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 5.312718e-01 0.275 0 0
p75NTR recruits signalling complexes R-HSA-209543 6.295098e-01 0.201 0 0
EPHB-mediated forward signaling R-HSA-3928662 5.414757e-01 0.266 0 0
DNA Damage Bypass R-HSA-73893 6.366760e-01 0.196 0 0
RNA Polymerase III Transcription R-HSA-74158 3.517191e-01 0.454 0 0
Synaptic adhesion-like molecules R-HSA-8849932 1.964204e-01 0.707 0 0
Hedgehog 'off' state R-HSA-5610787 3.176785e-01 0.498 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.820532e-01 0.418 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.374120e-01 0.359 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.478668e-01 0.459 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.907212e-01 0.720 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.907212e-01 0.720 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.777300e-01 0.750 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 3.683299e-01 0.434 0 0
Synthesis of DNA R-HSA-69239 6.219769e-01 0.206 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.694435e-01 0.570 0 0
Hedgehog 'on' state R-HSA-5632684 2.620972e-01 0.582 0 0
Regulation of the apoptosome activity R-HSA-9627069 5.176039e-01 0.286 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 5.246915e-01 0.280 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 5.946076e-01 0.226 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 6.535865e-01 0.185 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 2.565724e-01 0.591 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 6.434283e-01 0.191 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.853984e-01 0.414 0 0
Formation of apoptosome R-HSA-111458 5.176039e-01 0.286 0 0
PI3K/AKT activation R-HSA-198203 5.176039e-01 0.286 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 4.160207e-01 0.381 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 6.562678e-01 0.183 0 0
Prolonged ERK activation events R-HSA-169893 2.790552e-01 0.554 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.497106e-01 0.456 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.053407e-01 0.515 0 0
Signaling by EGFR R-HSA-177929 6.200863e-01 0.208 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.867823e-01 0.729 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 3.598971e-01 0.444 0 0
Signaling by RAS mutants R-HSA-6802949 1.907212e-01 0.720 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 4.773221e-01 0.321 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 5.246915e-01 0.280 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 5.011549e-01 0.300 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 4.239081e-01 0.373 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.914535e-01 0.718 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 2.169755e-01 0.664 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.818321e-01 0.740 0 0
Adrenoceptors R-HSA-390696 4.314576e-01 0.365 0 0
mTORC1-mediated signalling R-HSA-166208 3.198309e-01 0.495 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 3.956843e-01 0.403 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 3.457896e-01 0.461 0 0
Regulation of gap junction activity R-HSA-191650 5.510616e-01 0.259 0 0
Trafficking of AMPA receptors R-HSA-399719 3.731098e-01 0.428 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 4.457293e-01 0.351 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.717893e-01 0.243 0 0
Ligand-receptor interactions R-HSA-5632681 6.562678e-01 0.183 0 0
Cilium Assembly R-HSA-5617833 4.417765e-01 0.355 0 0
Signaling by Hedgehog R-HSA-5358351 5.018418e-01 0.299 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 5.949037e-01 0.226 0 0
MTOR signalling R-HSA-165159 2.290826e-01 0.640 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 4.052381e-01 0.392 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 5.888155e-01 0.230 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.153358e-01 0.667 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.153358e-01 0.667 0 0
Signaling by ROBO receptors R-HSA-376176 4.973354e-01 0.303 0 0
Signal attenuation R-HSA-74749 2.519867e-01 0.599 0 0
Rap1 signalling R-HSA-392517 3.981553e-01 0.400 0 0
Clathrin-mediated endocytosis R-HSA-8856828 3.208849e-01 0.494 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 4.663088e-01 0.331 0 0
RNA Polymerase I Transcription R-HSA-73864 4.776349e-01 0.321 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 6.083365e-01 0.216 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 6.295098e-01 0.201 0 0
Negative regulation of MAPK pathway R-HSA-5675221 3.328822e-01 0.478 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.653081e-01 0.248 0 0
Frs2-mediated activation R-HSA-170968 3.956843e-01 0.403 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.886134e-01 0.540 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 5.487129e-01 0.261 0 0
Signaling by NOTCH R-HSA-157118 2.524667e-01 0.598 0 0
TNF signaling R-HSA-75893 4.826759e-01 0.316 0 0
Meiosis R-HSA-1500620 2.659374e-01 0.575 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 2.400378e-01 0.620 0 0
Calcineurin activates NFAT R-HSA-2025928 2.169755e-01 0.664 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.891076e-01 0.539 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.964204e-01 0.707 0 0
Activation of SMO R-HSA-5635838 2.790552e-01 0.554 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 3.238112e-01 0.490 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.681699e-01 0.572 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 3.718673e-01 0.430 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 4.309145e-01 0.366 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.039846e-01 0.517 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.525647e-01 0.453 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.731106e-01 0.428 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 5.176039e-01 0.286 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 4.354719e-01 0.361 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.208843e-01 0.207 0 0
IRS-mediated signalling R-HSA-112399 6.370524e-01 0.196 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 6.438133e-01 0.191 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.103939e-01 0.508 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.896582e-01 0.722 0 0
IGF1R signaling cascade R-HSA-2428924 6.218771e-01 0.206 0 0
Regulation of TNFR1 signaling R-HSA-5357905 4.320734e-01 0.364 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 6.504054e-01 0.187 0 0
Signaling by FGFR1 in disease R-HSA-5655302 4.797717e-01 0.319 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.679878e-01 0.775 0 0
Signalling to ERKs R-HSA-187687 4.891286e-01 0.311 0 0
ESR-mediated signaling R-HSA-8939211 2.841511e-01 0.546 0 0
Regulation of necroptotic cell death R-HSA-5675482 5.949037e-01 0.226 0 0
Post NMDA receptor activation events R-HSA-438064 6.280012e-01 0.202 0 0
Signaling by WNT R-HSA-195721 1.727292e-01 0.763 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.400378e-01 0.620 0 0
FasL/ CD95L signaling R-HSA-75157 4.869442e-01 0.313 0 0
Inhibition of nitric oxide production R-HSA-9636249 4.869442e-01 0.313 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.309145e-01 0.366 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 5.510616e-01 0.259 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 5.624600e-01 0.250 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 6.174242e-01 0.209 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.562678e-01 0.183 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 4.432260e-01 0.353 0 0
Mismatch Repair R-HSA-5358508 5.923506e-01 0.227 0 0
Developmental Biology R-HSA-1266738 5.002702e-01 0.301 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 6.378740e-01 0.195 0 0
RAF/MAP kinase cascade R-HSA-5673001 4.734734e-01 0.325 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 5.317330e-01 0.274 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 2.400378e-01 0.620 0 0
Neurofascin interactions R-HSA-447043 3.377835e-01 0.471 0 0
ERK/MAPK targets R-HSA-198753 2.687827e-01 0.571 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.034328e-01 0.692 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.264403e-01 0.486 0 0
Vasopressin-like receptors R-HSA-388479 5.510616e-01 0.259 0 0
Myogenesis R-HSA-525793 4.239081e-01 0.373 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 6.174242e-01 0.209 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.569686e-01 0.447 0 0
Metabolism of RNA R-HSA-8953854 1.856930e-01 0.731 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 5.624600e-01 0.250 0 0
Reproduction R-HSA-1474165 3.127544e-01 0.505 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 5.674159e-01 0.246 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.808267e-01 0.552 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 3.443057e-01 0.463 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 3.443057e-01 0.463 0 0
Cell junction organization R-HSA-446728 1.782564e-01 0.749 0 0
Rab regulation of trafficking R-HSA-9007101 4.825083e-01 0.316 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 6.451048e-01 0.190 0 0
Signaling by BMP R-HSA-201451 4.496551e-01 0.347 0 0
Calmodulin induced events R-HSA-111933 2.206483e-01 0.656 0 0
Cell-cell junction organization R-HSA-421270 6.003274e-01 0.222 0 0
Ca2+ pathway R-HSA-4086398 6.390001e-01 0.194 0 0
Adherens junctions interactions R-HSA-418990 5.071084e-01 0.295 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.400378e-01 0.620 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 2.169755e-01 0.664 0 0
Ionotropic activity of kainate receptors R-HSA-451306 2.877268e-01 0.541 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 2.790552e-01 0.554 0 0
MET activates STAT3 R-HSA-8875791 4.869442e-01 0.313 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.869442e-01 0.313 0 0
Activation of BMF and translocation to mitochondria R-HSA-139910 4.869442e-01 0.313 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.867823e-01 0.729 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.766572e-01 0.753 0 0
Signaling by LTK R-HSA-9842663 3.598971e-01 0.444 0 0
CaM pathway R-HSA-111997 2.206483e-01 0.656 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.956843e-01 0.403 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.356586e-01 0.628 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.356586e-01 0.628 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.886134e-01 0.540 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.172638e-01 0.663 0 0
Unwinding of DNA R-HSA-176974 4.756067e-01 0.323 0 0
TBC/RABGAPs R-HSA-8854214 3.723783e-01 0.429 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 5.176039e-01 0.286 0 0
Signaling by VEGF R-HSA-194138 4.104490e-01 0.387 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 6.071694e-01 0.217 0 0
Reelin signalling pathway R-HSA-8866376 6.071694e-01 0.217 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.487129e-01 0.261 0 0
Metalloprotease DUBs R-HSA-5689901 6.177492e-01 0.209 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.208843e-01 0.207 0 0
TRAIL signaling R-HSA-75158 6.562678e-01 0.183 0 0
Pentose phosphate pathway disease R-HSA-6791465 6.562678e-01 0.183 0 0
Formation of the Editosome R-HSA-75094 6.562678e-01 0.183 0 0
Synthesis of PS R-HSA-1483101 6.562678e-01 0.183 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.562678e-01 0.183 0 0
PI3K Cascade R-HSA-109704 6.542973e-01 0.184 0 0
Cell-Cell communication R-HSA-1500931 3.366861e-01 0.473 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 3.492206e-01 0.457 0 0
Organelle biogenesis and maintenance R-HSA-1852241 6.596636e-01 0.181 0 0
MAPK family signaling cascades R-HSA-5683057 5.759097e-01 0.240 0 0
Oncogene Induced Senescence R-HSA-2559585 4.891286e-01 0.311 0 0
Signaling by FGFR4 in disease R-HSA-5655291 4.309145e-01 0.366 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 5.176039e-01 0.286 0 0
Pexophagy R-HSA-9664873 5.176039e-01 0.286 0 0
Signaling by ERBB4 R-HSA-1236394 4.139327e-01 0.383 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 6.200863e-01 0.208 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 4.847135e-01 0.315 0 0
Ca-dependent events R-HSA-111996 3.525647e-01 0.453 0 0
HIV Life Cycle R-HSA-162587 3.934708e-01 0.405 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 5.624600e-01 0.250 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 5.624600e-01 0.250 0 0
Signaling by FGFR in disease R-HSA-1226099 6.538351e-01 0.185 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.264403e-01 0.486 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 1.750286e-01 0.757 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 3.085948e-01 0.511 0 0
Kinesins R-HSA-983189 2.039093e-01 0.691 0 0
MDK and PTN in ALK signaling R-HSA-9851151 5.510616e-01 0.259 0 0
DAG and IP3 signaling R-HSA-1489509 4.121843e-01 0.385 0 0
Recycling pathway of L1 R-HSA-437239 4.518878e-01 0.345 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 6.184123e-01 0.209 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.855005e-01 0.732 0 0
Signaling by NODAL R-HSA-1181150 6.480239e-01 0.188 0 0
Netrin-1 signaling R-HSA-373752 2.628437e-01 0.580 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 3.723783e-01 0.429 0 0
Apoptosis R-HSA-109581 3.693469e-01 0.433 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.891076e-01 0.539 0 0
CHL1 interactions R-HSA-447041 3.853984e-01 0.414 0 0
Uptake and function of anthrax toxins R-HSA-5210891 3.384172e-01 0.471 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 4.314576e-01 0.365 0 0
Protein hydroxylation R-HSA-9629569 4.277324e-01 0.369 0 0
Signaling by Activin R-HSA-1502540 4.653700e-01 0.332 0 0
Formation of intermediate mesoderm R-HSA-9761174 5.176039e-01 0.286 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 4.675498e-01 0.330 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 6.562678e-01 0.183 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 6.562678e-01 0.183 0 0
Signaling by PTK6 R-HSA-8848021 2.450110e-01 0.611 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.450110e-01 0.611 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.802771e-01 0.552 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 6.535865e-01 0.185 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 6.620232e-01 0.179 0 0
Activation of BH3-only proteins R-HSA-114452 3.497106e-01 0.456 0 0
Formation of the nephric duct R-HSA-9830364 5.930438e-01 0.227 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 3.384172e-01 0.471 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 5.923506e-01 0.227 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 4.730056e-01 0.325 0 0
PI Metabolism R-HSA-1483255 4.401572e-01 0.356 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 4.569165e-01 0.340 0 0
L1CAM interactions R-HSA-373760 4.696705e-01 0.328 0 0
Signaling by TGFBR3 R-HSA-9839373 2.980204e-01 0.526 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 5.006326e-01 0.300 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.299463e-01 0.482 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 2.519867e-01 0.599 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 2.790552e-01 0.554 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.869442e-01 0.313 0 0
Maturation of nucleoprotein R-HSA-9683610 3.956843e-01 0.403 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 4.309145e-01 0.366 0 0
Sensory perception of sour taste R-HSA-9729555 5.510616e-01 0.259 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 4.199486e-01 0.377 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 4.569165e-01 0.340 0 0
Tandem pore domain potassium channels R-HSA-1296346 5.176039e-01 0.286 0 0
Signaling by PDGFR in disease R-HSA-9671555 4.855799e-01 0.314 0 0
Synthesis of PI R-HSA-1483226 5.572976e-01 0.254 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 5.572976e-01 0.254 0 0
PTK6 Down-Regulation R-HSA-8849472 6.071694e-01 0.217 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 5.674159e-01 0.246 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 4.374120e-01 0.359 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.198309e-01 0.495 0 0
Sensory processing of sound R-HSA-9659379 3.794571e-01 0.421 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 3.328822e-01 0.478 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.831161e-01 0.737 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.169755e-01 0.664 0 0
Interleukin-37 signaling R-HSA-9008059 2.096126e-01 0.679 0 0
Maturation of nucleoprotein R-HSA-9694631 3.981553e-01 0.400 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 4.309145e-01 0.366 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 4.756067e-01 0.323 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.193022e-01 0.496 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 4.653700e-01 0.332 0 0
Tie2 Signaling R-HSA-210993 5.923506e-01 0.227 0 0
Potential therapeutics for SARS R-HSA-9679191 6.473804e-01 0.189 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 4.653700e-01 0.332 0 0
Syndecan interactions R-HSA-3000170 5.409169e-01 0.267 0 0
Diseases of DNA repair R-HSA-9675135 2.980204e-01 0.526 0 0
Glycolysis R-HSA-70171 1.668463e-01 0.778 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.671395e-01 0.777 0 0
Dopamine receptors R-HSA-390651 1.914535e-01 0.718 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.853984e-01 0.414 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 5.510616e-01 0.259 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 2.777095e-01 0.556 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 3.522402e-01 0.453 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 4.199486e-01 0.377 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 4.988708e-01 0.302 0 0
Bicarbonate transporters R-HSA-425381 5.572976e-01 0.254 0 0
Anchoring fibril formation R-HSA-2214320 5.946076e-01 0.226 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 6.055182e-01 0.218 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 6.177492e-01 0.209 0 0
Relaxin receptors R-HSA-444821 6.562678e-01 0.183 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.562678e-01 0.183 0 0
Signaling by NOTCH4 R-HSA-9013694 6.538351e-01 0.185 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 2.806538e-01 0.552 0 0
Inositol phosphate metabolism R-HSA-1483249 3.040912e-01 0.517 0 0
Signaling by ALK R-HSA-201556 5.766135e-01 0.239 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 5.674159e-01 0.246 0 0
Neurodegenerative Diseases R-HSA-8863678 5.674159e-01 0.246 0 0
Gene Silencing by RNA R-HSA-211000 4.221835e-01 0.374 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.687827e-01 0.571 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 6.414931e-01 0.193 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.400378e-01 0.620 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 2.687827e-01 0.571 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.907212e-01 0.720 0 0
Interleukin-38 signaling R-HSA-9007892 5.510616e-01 0.259 0 0
Interleukin-7 signaling R-HSA-1266695 2.365063e-01 0.626 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 3.514662e-01 0.454 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.683299e-01 0.434 0 0
Interleukin-15 signaling R-HSA-8983432 6.295098e-01 0.201 0 0
Glucose metabolism R-HSA-70326 3.892329e-01 0.410 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.885289e-01 0.411 0 0
Physiological factors R-HSA-5578768 4.309145e-01 0.366 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.517191e-01 0.454 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 4.410148e-01 0.356 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 6.414931e-01 0.193 0 0
Signaling by Leptin R-HSA-2586552 5.176039e-01 0.286 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 6.403391e-01 0.194 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 6.696731e-01 0.174 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 6.699437e-01 0.174 0 0
Response of endothelial cells to shear stress R-HSA-9860931 6.699437e-01 0.174 0 0
Programmed Cell Death R-HSA-5357801 6.702929e-01 0.174 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 6.737512e-01 0.172 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 6.737512e-01 0.172 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 6.737512e-01 0.172 0 0
Basigin interactions R-HSA-210991 6.737512e-01 0.172 0 0
DNA Replication R-HSA-69306 6.778739e-01 0.169 0 0
Triglyceride catabolism R-HSA-163560 6.787561e-01 0.168 0 0
UCH proteinases R-HSA-5689603 6.824499e-01 0.166 0 0
Signaling by Erythropoietin R-HSA-9006335 6.859966e-01 0.164 0 0
mRNA Capping R-HSA-72086 6.859966e-01 0.164 0 0
DNA methylation R-HSA-5334118 6.859966e-01 0.164 0 0
Late endosomal microautophagy R-HSA-9615710 6.859966e-01 0.164 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 6.859966e-01 0.164 0 0
DARPP-32 events R-HSA-180024 6.859966e-01 0.164 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 6.879616e-01 0.162 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 6.879616e-01 0.162 0 0
Removal of the Flap Intermediate R-HSA-69166 6.921997e-01 0.160 0 0
NRIF signals cell death from the nucleus R-HSA-205043 6.921997e-01 0.160 0 0
Retrograde neurotrophin signalling R-HSA-177504 6.921997e-01 0.160 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 6.939034e-01 0.159 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 6.939034e-01 0.159 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 6.939034e-01 0.159 0 0
Degradation of AXIN R-HSA-4641257 6.977954e-01 0.156 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 6.979558e-01 0.156 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.992321e-01 0.155 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.992321e-01 0.155 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 6.992321e-01 0.155 0 0
MET Receptor Activation R-HSA-6806942 6.992321e-01 0.155 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 6.992321e-01 0.155 0 0
CREB phosphorylation R-HSA-199920 6.992321e-01 0.155 0 0
NADPH regeneration R-HSA-389542 6.992321e-01 0.155 0 0
Lipid particle organization R-HSA-8964572 6.992321e-01 0.155 0 0
CREB3 factors activate genes R-HSA-8874211 6.992321e-01 0.155 0 0
MAP kinase activation R-HSA-450294 7.004553e-01 0.155 0 0
PLC beta mediated events R-HSA-112043 7.004553e-01 0.155 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 7.039803e-01 0.152 0 0
Amino acids regulate mTORC1 R-HSA-9639288 7.039803e-01 0.152 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 7.050584e-01 0.152 0 0
SARS-CoV-1-host interactions R-HSA-9692914 7.053168e-01 0.152 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 7.063005e-01 0.151 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 7.078800e-01 0.150 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 7.089487e-01 0.149 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 7.089487e-01 0.149 0 0
Nucleosome assembly R-HSA-774815 7.089487e-01 0.149 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 7.089487e-01 0.149 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 7.089487e-01 0.149 0 0
Nuclear Receptor transcription pathway R-HSA-383280 7.095950e-01 0.149 0 0
Interleukin-17 signaling R-HSA-448424 7.119462e-01 0.148 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 7.151328e-01 0.146 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 7.160409e-01 0.145 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 7.201153e-01 0.143 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 7.201153e-01 0.143 0 0
Translesion synthesis by REV1 R-HSA-110312 7.201153e-01 0.143 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 7.201153e-01 0.143 0 0
Processive synthesis on the lagging strand R-HSA-69183 7.201153e-01 0.143 0 0
Spry regulation of FGF signaling R-HSA-1295596 7.201153e-01 0.143 0 0
p75NTR signals via NF-kB R-HSA-193639 7.201153e-01 0.143 0 0
Telomere C-strand synthesis initiation R-HSA-174430 7.201153e-01 0.143 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 7.201153e-01 0.143 0 0
Protein methylation R-HSA-8876725 7.201153e-01 0.143 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 7.209760e-01 0.142 0 0
Cellular response to starvation R-HSA-9711097 7.253568e-01 0.139 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 7.255099e-01 0.139 0 0
Downstream signal transduction R-HSA-186763 7.264511e-01 0.139 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 7.266485e-01 0.139 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 7.304412e-01 0.136 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 7.334904e-01 0.135 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.334904e-01 0.135 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 7.343529e-01 0.134 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.352170e-01 0.134 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 7.352170e-01 0.134 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 7.354025e-01 0.133 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 7.368283e-01 0.133 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 7.368283e-01 0.133 0 0
IFNG signaling activates MAPKs R-HSA-9732724 7.368283e-01 0.133 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 7.368283e-01 0.133 0 0
Recycling of eIF2:GDP R-HSA-72731 7.368283e-01 0.133 0 0
mRNA Editing: C to U Conversion R-HSA-72200 7.368283e-01 0.133 0 0
PTK6 Expression R-HSA-8849473 7.368283e-01 0.133 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 7.368283e-01 0.133 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 7.368283e-01 0.133 0 0
Ca2+ activated K+ channels R-HSA-1296052 7.368283e-01 0.133 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.368283e-01 0.133 0 0
VLDL clearance R-HSA-8964046 7.368283e-01 0.133 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 7.368283e-01 0.133 0 0
Maturation of replicase proteins R-HSA-9694301 7.368283e-01 0.133 0 0
Signaling by Nuclear Receptors R-HSA-9006931 7.389340e-01 0.131 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.425093e-01 0.129 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.425093e-01 0.129 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 7.425093e-01 0.129 0 0
Insulin receptor signalling cascade R-HSA-74751 7.430324e-01 0.129 0 0
Ion transport by P-type ATPases R-HSA-936837 7.430324e-01 0.129 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 7.433544e-01 0.129 0 0
Selective autophagy R-HSA-9663891 7.443371e-01 0.128 0 0
Diseases of programmed cell death R-HSA-9645723 7.443371e-01 0.128 0 0
DNA strand elongation R-HSA-69190 7.451644e-01 0.128 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 7.451644e-01 0.128 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 7.458638e-01 0.127 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 7.458638e-01 0.127 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 7.458638e-01 0.127 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 7.458638e-01 0.127 0 0
Phase 4 - resting membrane potential R-HSA-5576886 7.458638e-01 0.127 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 7.458638e-01 0.127 0 0
Host Interactions of HIV factors R-HSA-162909 7.460016e-01 0.127 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 7.487001e-01 0.126 0 0
Ion homeostasis R-HSA-5578775 7.487001e-01 0.126 0 0
Attenuation phase R-HSA-3371568 7.501461e-01 0.125 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 7.501461e-01 0.125 0 0
Aggrephagy R-HSA-9646399 7.501461e-01 0.125 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 7.501461e-01 0.125 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 7.501461e-01 0.125 0 0
Interleukin-2 family signaling R-HSA-451927 7.501461e-01 0.125 0 0
Deadenylation of mRNA R-HSA-429947 7.626972e-01 0.118 0 0
FGFR1 mutant receptor activation R-HSA-1839124 7.628841e-01 0.118 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 7.636976e-01 0.117 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 7.695506e-01 0.114 0 0
Translesion synthesis by POLK R-HSA-5655862 7.695506e-01 0.114 0 0
Glycine degradation R-HSA-6783984 7.695506e-01 0.114 0 0
Passive transport by Aquaporins R-HSA-432047 7.695506e-01 0.114 0 0
Fibronectin matrix formation R-HSA-1566977 7.695506e-01 0.114 0 0
Synthesis of PG R-HSA-1483148 7.695506e-01 0.114 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 7.697268e-01 0.114 0 0
RSK activation R-HSA-444257 7.697268e-01 0.114 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.697268e-01 0.114 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.697268e-01 0.114 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 7.697268e-01 0.114 0 0
Formation of annular gap junctions R-HSA-196025 7.697268e-01 0.114 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 7.697268e-01 0.114 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.697268e-01 0.114 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.697268e-01 0.114 0 0
Alpha-defensins R-HSA-1462054 7.697268e-01 0.114 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.697268e-01 0.114 0 0
Sodium/Proton exchangers R-HSA-425986 7.697268e-01 0.114 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.707340e-01 0.113 0 0
Influenza Infection R-HSA-168255 7.749465e-01 0.111 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 7.761238e-01 0.110 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 7.761238e-01 0.110 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 7.796289e-01 0.108 0 0
Effects of PIP2 hydrolysis R-HSA-114508 7.796289e-01 0.108 0 0
HIV Infection R-HSA-162906 7.801378e-01 0.108 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 7.810724e-01 0.107 0 0
Degradation of CRY and PER proteins R-HSA-9932298 7.811065e-01 0.107 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 7.811065e-01 0.107 0 0
G-protein mediated events R-HSA-112040 7.812202e-01 0.107 0 0
Tight junction interactions R-HSA-420029 7.815801e-01 0.107 0 0
Signaling by FGFR2 in disease R-HSA-5655253 7.842978e-01 0.106 0 0
SARS-CoV-2-host interactions R-HSA-9705683 7.868550e-01 0.104 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 7.879939e-01 0.103 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 7.883963e-01 0.103 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 7.912887e-01 0.102 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 7.912887e-01 0.102 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 7.912887e-01 0.102 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 7.912887e-01 0.102 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 7.912887e-01 0.102 0 0
Chromosome Maintenance R-HSA-73886 7.940848e-01 0.100 0 0
Dual Incision in GG-NER R-HSA-5696400 7.954219e-01 0.099 0 0
Signaling by NOTCH2 R-HSA-1980145 7.954219e-01 0.099 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 7.954219e-01 0.099 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 7.954219e-01 0.099 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 7.954349e-01 0.099 0 0
Meiotic recombination R-HSA-912446 7.974295e-01 0.098 0 0
EPH-Ephrin signaling R-HSA-2682334 7.980225e-01 0.098 0 0
ARMS-mediated activation R-HSA-170984 7.985145e-01 0.098 0 0
Gap junction degradation R-HSA-190873 7.985145e-01 0.098 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.985145e-01 0.098 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 7.985145e-01 0.098 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.985145e-01 0.098 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 7.985145e-01 0.098 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.985145e-01 0.098 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 7.985145e-01 0.098 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.985145e-01 0.098 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.985145e-01 0.098 0 0
mRNA Editing R-HSA-75072 7.985145e-01 0.098 0 0
Interleukin-1 processing R-HSA-448706 7.985145e-01 0.098 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 7.985145e-01 0.098 0 0
Cellular response to mitochondrial stress R-HSA-9840373 7.985145e-01 0.098 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 7.985145e-01 0.098 0 0
MET activates PTK2 signaling R-HSA-8874081 7.992043e-01 0.097 0 0
Signaling by EGFR in Cancer R-HSA-1643713 7.992043e-01 0.097 0 0
TRP channels R-HSA-3295583 7.992043e-01 0.097 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 8.026734e-01 0.095 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 8.026734e-01 0.095 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 8.055281e-01 0.094 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 8.088183e-01 0.092 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 8.088183e-01 0.092 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 8.088183e-01 0.092 0 0
Signaling by FGFR4 R-HSA-5654743 8.090163e-01 0.092 0 0
Defective pyroptosis R-HSA-9710421 8.090163e-01 0.092 0 0
Orc1 removal from chromatin R-HSA-68949 8.099355e-01 0.092 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.099355e-01 0.092 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.099355e-01 0.092 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 8.102899e-01 0.091 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.107021e-01 0.091 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 8.110023e-01 0.091 0 0
Apoptotic factor-mediated response R-HSA-111471 8.111952e-01 0.091 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 8.111952e-01 0.091 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 8.111952e-01 0.091 0 0
Aquaporin-mediated transport R-HSA-445717 8.121229e-01 0.090 0 0
Formation of paraxial mesoderm R-HSA-9793380 8.121229e-01 0.090 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 8.150713e-01 0.089 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.156204e-01 0.089 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 8.156204e-01 0.089 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.156204e-01 0.089 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 8.156204e-01 0.089 0 0
Maturation of hRSV A proteins R-HSA-9828806 8.156204e-01 0.089 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 8.174721e-01 0.088 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 8.218693e-01 0.085 0 0
MAPK3 (ERK1) activation R-HSA-110056 8.237047e-01 0.084 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 8.237047e-01 0.084 0 0
DNA replication initiation R-HSA-68952 8.237047e-01 0.084 0 0
Regulation of CDH11 function R-HSA-9762292 8.237047e-01 0.084 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 8.237047e-01 0.084 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 8.237047e-01 0.084 0 0
Arachidonate production from DAG R-HSA-426048 8.237047e-01 0.084 0 0
Receptor Mediated Mitophagy R-HSA-8934903 8.237047e-01 0.084 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 8.237047e-01 0.084 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 8.237047e-01 0.084 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.237047e-01 0.084 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 8.242626e-01 0.084 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.242626e-01 0.084 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 8.258325e-01 0.083 0 0
MyD88-independent TLR4 cascade R-HSA-166166 8.258325e-01 0.083 0 0
Signaling by FGFR2 R-HSA-5654738 8.281958e-01 0.082 0 0
Translesion Synthesis by POLH R-HSA-110320 8.293880e-01 0.081 0 0
Regulation of signaling by CBL R-HSA-912631 8.293880e-01 0.081 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 8.293880e-01 0.081 0 0
Crosslinking of collagen fibrils R-HSA-2243919 8.293880e-01 0.081 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 8.293880e-01 0.081 0 0
The NLRP3 inflammasome R-HSA-844456 8.293880e-01 0.081 0 0
Other interleukin signaling R-HSA-449836 8.293880e-01 0.081 0 0
Mitochondrial biogenesis R-HSA-1592230 8.301753e-01 0.081 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 8.308821e-01 0.080 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.308821e-01 0.080 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 8.314317e-01 0.080 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 8.340145e-01 0.079 0 0
Fanconi Anemia Pathway R-HSA-6783310 8.340145e-01 0.079 0 0
Signaling by FGFR3 R-HSA-5654741 8.340145e-01 0.079 0 0
Formation of a pool of free 40S subunits R-HSA-72689 8.346683e-01 0.078 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.373719e-01 0.077 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.373719e-01 0.077 0 0
Collagen chain trimerization R-HSA-8948216 8.373719e-01 0.077 0 0
Autophagy R-HSA-9612973 8.378457e-01 0.077 0 0
Opioid Signalling R-HSA-111885 8.381433e-01 0.077 0 0
Macroautophagy R-HSA-1632852 8.427476e-01 0.074 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 8.450452e-01 0.073 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.450452e-01 0.073 0 0
Platelet calcium homeostasis R-HSA-418360 8.450452e-01 0.073 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 8.457468e-01 0.073 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 8.457468e-01 0.073 0 0
Interleukin-2 signaling R-HSA-9020558 8.457468e-01 0.073 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 8.457468e-01 0.073 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 8.457468e-01 0.073 0 0
vRNA Synthesis R-HSA-192814 8.457468e-01 0.073 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.457468e-01 0.073 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 8.457468e-01 0.073 0 0
LGI-ADAM interactions R-HSA-5682910 8.457468e-01 0.073 0 0
Suppression of apoptosis R-HSA-9635465 8.457468e-01 0.073 0 0
PECAM1 interactions R-HSA-210990 8.457468e-01 0.073 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 8.459845e-01 0.073 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 8.459845e-01 0.073 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 8.459845e-01 0.073 0 0
Pregnenolone biosynthesis R-HSA-196108 8.459845e-01 0.073 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 8.491898e-01 0.071 0 0
Cellular response to hypoxia R-HSA-1234174 8.533325e-01 0.069 0 0
Membrane Trafficking R-HSA-199991 8.553732e-01 0.068 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.581667e-01 0.066 0 0
DAP12 signaling R-HSA-2424491 8.581667e-01 0.066 0 0
Co-inhibition by PD-1 R-HSA-389948 8.582603e-01 0.066 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 8.610994e-01 0.065 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.610994e-01 0.065 0 0
Lagging Strand Synthesis R-HSA-69186 8.610994e-01 0.065 0 0
Stabilization of p53 R-HSA-69541 8.611367e-01 0.065 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.623493e-01 0.064 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 8.650342e-01 0.063 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 8.650342e-01 0.063 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 8.650342e-01 0.063 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 8.650342e-01 0.063 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.650342e-01 0.063 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.650342e-01 0.063 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.650342e-01 0.063 0 0
NF-kB is activated and signals survival R-HSA-209560 8.650342e-01 0.063 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.650342e-01 0.063 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.650342e-01 0.063 0 0
Sodium/Calcium exchangers R-HSA-425561 8.650342e-01 0.063 0 0
DS-GAG biosynthesis R-HSA-2022923 8.650342e-01 0.063 0 0
Integration of provirus R-HSA-162592 8.650342e-01 0.063 0 0
Interleukin-1 family signaling R-HSA-446652 8.652965e-01 0.063 0 0
Co-stimulation by CD28 R-HSA-389356 8.664321e-01 0.062 0 0
Cargo concentration in the ER R-HSA-5694530 8.703036e-01 0.060 0 0
Kidney development R-HSA-9830369 8.710127e-01 0.060 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.718630e-01 0.060 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.718630e-01 0.060 0 0
Diseases of Immune System R-HSA-5260271 8.718630e-01 0.060 0 0
MHC class II antigen presentation R-HSA-2132295 8.723205e-01 0.059 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.748436e-01 0.058 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 8.748436e-01 0.058 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 8.748436e-01 0.058 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 8.748436e-01 0.058 0 0
Mitochondrial calcium ion transport R-HSA-8949215 8.748436e-01 0.058 0 0
Triglyceride metabolism R-HSA-8979227 8.812144e-01 0.055 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.818666e-01 0.055 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 8.818666e-01 0.055 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 8.819109e-01 0.055 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.819109e-01 0.055 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.819109e-01 0.055 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.819109e-01 0.055 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.819109e-01 0.055 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.819109e-01 0.055 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.819109e-01 0.055 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.819109e-01 0.055 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.819109e-01 0.055 0 0
Estrogen biosynthesis R-HSA-193144 8.819109e-01 0.055 0 0
OAS antiviral response R-HSA-8983711 8.819109e-01 0.055 0 0
Eukaryotic Translation Initiation R-HSA-72613 8.826426e-01 0.054 0 0
Cap-dependent Translation Initiation R-HSA-72737 8.826426e-01 0.054 0 0
Collagen formation R-HSA-1474290 8.855346e-01 0.053 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 8.873235e-01 0.052 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.873235e-01 0.052 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.873235e-01 0.052 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.873235e-01 0.052 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 8.911837e-01 0.050 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 8.911837e-01 0.050 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.911837e-01 0.050 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.911837e-01 0.050 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.918508e-01 0.050 0 0
Integrin signaling R-HSA-354192 8.918508e-01 0.050 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 8.919676e-01 0.050 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 8.942007e-01 0.049 0 0
Cellular responses to stress R-HSA-2262752 8.944794e-01 0.048 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.966781e-01 0.047 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.966781e-01 0.047 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.966781e-01 0.047 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 8.966781e-01 0.047 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 8.966781e-01 0.047 0 0
Chylomicron remodeling R-HSA-8963901 8.966781e-01 0.047 0 0
Mtb iron assimilation by chelation R-HSA-1222449 8.966781e-01 0.047 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.966781e-01 0.047 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.966781e-01 0.047 0 0
Processing of SMDT1 R-HSA-8949664 8.966781e-01 0.047 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.966781e-01 0.047 0 0
Interleukin-6 signaling R-HSA-1059683 8.966781e-01 0.047 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.966781e-01 0.047 0 0
Collagen degradation R-HSA-1442490 8.968838e-01 0.047 0 0
Peptide chain elongation R-HSA-156902 8.983958e-01 0.047 0 0
Termination of O-glycan biosynthesis R-HSA-977068 8.986404e-01 0.046 0 0
Carnitine shuttle R-HSA-200425 8.986404e-01 0.046 0 0
Organic anion transport by SLCO transporters R-HSA-879518 8.986404e-01 0.046 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 8.986404e-01 0.046 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 8.986404e-01 0.046 0 0
Formation of the ureteric bud R-HSA-9830674 8.986404e-01 0.046 0 0
Growth hormone receptor signaling R-HSA-982772 8.986404e-01 0.046 0 0
PKR-mediated signaling R-HSA-9833482 8.993260e-01 0.046 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.998503e-01 0.046 0 0
Depyrimidination R-HSA-73928 8.998503e-01 0.046 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.012055e-01 0.045 0 0
Striated Muscle Contraction R-HSA-390522 9.013720e-01 0.045 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.013720e-01 0.045 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.013720e-01 0.045 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.085608e-01 0.042 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 9.085608e-01 0.042 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 9.088898e-01 0.041 0 0
Complex III assembly R-HSA-9865881 9.088898e-01 0.041 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 9.095994e-01 0.041 0 0
cGMP effects R-HSA-418457 9.095994e-01 0.041 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.095994e-01 0.041 0 0
Glycerophospholipid catabolism R-HSA-6814848 9.095994e-01 0.041 0 0
Malate-aspartate shuttle R-HSA-9856872 9.095994e-01 0.041 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 9.095994e-01 0.041 0 0
HDL assembly R-HSA-8963896 9.095994e-01 0.041 0 0
Signal regulatory protein family interactions R-HSA-391160 9.095994e-01 0.041 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 9.095994e-01 0.041 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 9.101297e-01 0.041 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.101297e-01 0.041 0 0
NOD1/2 Signaling Pathway R-HSA-168638 9.101297e-01 0.041 0 0
Mitophagy R-HSA-5205647 9.101297e-01 0.041 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.101297e-01 0.041 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.113919e-01 0.040 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 9.137627e-01 0.039 0 0
Amine ligand-binding receptors R-HSA-375280 9.153732e-01 0.038 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 9.154322e-01 0.038 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.156806e-01 0.038 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.158277e-01 0.038 0 0
tRNA processing R-HSA-72306 9.160313e-01 0.038 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.181617e-01 0.037 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.181617e-01 0.037 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.181617e-01 0.037 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.181617e-01 0.037 0 0
Laminin interactions R-HSA-3000157 9.181617e-01 0.037 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.181617e-01 0.037 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.181753e-01 0.037 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.181753e-01 0.037 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.181753e-01 0.037 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 9.209055e-01 0.036 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.209055e-01 0.036 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.209055e-01 0.036 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 9.209055e-01 0.036 0 0
Protein lipoylation R-HSA-9857492 9.209055e-01 0.036 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 9.209055e-01 0.036 0 0
SHC1 events in EGFR signaling R-HSA-180336 9.209055e-01 0.036 0 0
Biotin transport and metabolism R-HSA-196780 9.209055e-01 0.036 0 0
DNA Damage Reversal R-HSA-73942 9.209055e-01 0.036 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 9.209055e-01 0.036 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 9.209055e-01 0.036 0 0
FASTK family proteins regulate processing and stability of mitochondrial RNAs R-HSA-9837092 9.209055e-01 0.036 0 0
Other semaphorin interactions R-HSA-416700 9.209055e-01 0.036 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 9.212935e-01 0.036 0 0
Signaling by Interleukins R-HSA-449147 9.214734e-01 0.036 0 0
PPARA activates gene expression R-HSA-1989781 9.216355e-01 0.035 0 0
G alpha (z) signalling events R-HSA-418597 9.218446e-01 0.035 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.222982e-01 0.035 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.222982e-01 0.035 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.222982e-01 0.035 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 9.222982e-01 0.035 0 0
Somitogenesis R-HSA-9824272 9.222982e-01 0.035 0 0
Cellular responses to stimuli R-HSA-8953897 9.246394e-01 0.034 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.249999e-01 0.034 0 0
HSF1 activation R-HSA-3371511 9.255580e-01 0.034 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.255580e-01 0.034 0 0
Signaling by Insulin receptor R-HSA-74752 9.257572e-01 0.034 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.257572e-01 0.034 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 9.265403e-01 0.033 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.265403e-01 0.033 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.265403e-01 0.033 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 9.275537e-01 0.033 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 9.278225e-01 0.033 0 0
Signaling by FGFR1 R-HSA-5654736 9.278225e-01 0.033 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.287098e-01 0.032 0 0
Interleukin-1 signaling R-HSA-9020702 9.290883e-01 0.032 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.290993e-01 0.032 0 0
Toll-like Receptor Cascades R-HSA-168898 9.291830e-01 0.032 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 9.307981e-01 0.031 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 9.307981e-01 0.031 0 0
Killing mechanisms R-HSA-9664420 9.307981e-01 0.031 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 9.307981e-01 0.031 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 9.307981e-01 0.031 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.323248e-01 0.030 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.323248e-01 0.030 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 9.341039e-01 0.030 0 0
Packaging Of Telomere Ends R-HSA-171306 9.341039e-01 0.030 0 0
Cristae formation R-HSA-8949613 9.341039e-01 0.030 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.341039e-01 0.030 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 9.346398e-01 0.029 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.346398e-01 0.029 0 0
Translation of Structural Proteins R-HSA-9694635 9.349386e-01 0.029 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 9.385428e-01 0.028 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.385428e-01 0.028 0 0
Regulated Necrosis R-HSA-5218859 9.385428e-01 0.028 0 0
Dual incision in TC-NER R-HSA-6782135 9.385696e-01 0.028 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.394539e-01 0.027 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 9.394539e-01 0.027 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 9.394539e-01 0.027 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.394539e-01 0.027 0 0
Coenzyme A biosynthesis R-HSA-196783 9.394539e-01 0.027 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 9.394539e-01 0.027 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.394539e-01 0.027 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.394539e-01 0.027 0 0
PCP/CE pathway R-HSA-4086400 9.394587e-01 0.027 0 0
GPER1 signaling R-HSA-9634597 9.401188e-01 0.027 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 9.409253e-01 0.026 0 0
Telomere Extension By Telomerase R-HSA-171319 9.409253e-01 0.026 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.409253e-01 0.026 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 9.409253e-01 0.026 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.409253e-01 0.026 0 0
Inflammasomes R-HSA-622312 9.409253e-01 0.026 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.428315e-01 0.026 0 0
Eukaryotic Translation Termination R-HSA-72764 9.428315e-01 0.026 0 0
Extension of Telomeres R-HSA-180786 9.433844e-01 0.025 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.441878e-01 0.025 0 0
RSV-host interactions R-HSA-9833110 9.449165e-01 0.025 0 0
Degradation of CDH1 R-HSA-9766229 9.451761e-01 0.024 0 0
Integration of energy metabolism R-HSA-163685 9.452391e-01 0.024 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.465205e-01 0.024 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 9.470275e-01 0.024 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 9.470275e-01 0.024 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.470275e-01 0.024 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.470717e-01 0.024 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.470717e-01 0.024 0 0
Glucagon-type ligand receptors R-HSA-420092 9.470717e-01 0.024 0 0
Telomere Maintenance R-HSA-157579 9.499981e-01 0.022 0 0
Ribosome-associated quality control R-HSA-9948299 9.511380e-01 0.022 0 0
Amyloid fiber formation R-HSA-977225 9.513948e-01 0.022 0 0
Neurotransmitter release cycle R-HSA-112310 9.521373e-01 0.021 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.526053e-01 0.021 0 0
Signaling by FGFR R-HSA-190236 9.532741e-01 0.021 0 0
Ephrin signaling R-HSA-3928664 9.536541e-01 0.021 0 0
GAB1 signalosome R-HSA-180292 9.536541e-01 0.021 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 9.536541e-01 0.021 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.536541e-01 0.021 0 0
Platelet sensitization by LDL R-HSA-432142 9.536541e-01 0.021 0 0
Nephron development R-HSA-9831926 9.536541e-01 0.021 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 9.539878e-01 0.020 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.540940e-01 0.020 0 0
Maturation of spike protein R-HSA-9694548 9.540940e-01 0.020 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.541363e-01 0.020 0 0
Cardiac conduction R-HSA-5576891 9.544242e-01 0.020 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.546681e-01 0.020 0 0
Signaling by PDGF R-HSA-186797 9.558508e-01 0.020 0 0
Mitochondrial protein import R-HSA-1268020 9.558508e-01 0.020 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.558508e-01 0.020 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.575831e-01 0.019 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.575831e-01 0.019 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.579740e-01 0.019 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.580914e-01 0.019 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.584062e-01 0.018 0 0
Translation of Structural Proteins R-HSA-9683701 9.584062e-01 0.018 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.592753e-01 0.018 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 9.594521e-01 0.018 0 0
Diseases of hemostasis R-HSA-9671793 9.594521e-01 0.018 0 0
STING mediated induction of host immune responses R-HSA-1834941 9.594521e-01 0.018 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 9.594521e-01 0.018 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.594521e-01 0.018 0 0
Selenocysteine synthesis R-HSA-2408557 9.619869e-01 0.017 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.620576e-01 0.017 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.620576e-01 0.017 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.620576e-01 0.017 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.623360e-01 0.017 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.627108e-01 0.017 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.644988e-01 0.016 0 0
Co-inhibition by CTLA4 R-HSA-389513 9.645250e-01 0.016 0 0
Creatine metabolism R-HSA-71288 9.645250e-01 0.016 0 0
Signal transduction by L1 R-HSA-445144 9.645250e-01 0.016 0 0
Nephrin family interactions R-HSA-373753 9.645250e-01 0.016 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.650716e-01 0.015 0 0
G-protein beta:gamma signalling R-HSA-397795 9.660768e-01 0.015 0 0
Recycling of bile acids and salts R-HSA-159418 9.660768e-01 0.015 0 0
SARS-CoV Infections R-HSA-9679506 9.663133e-01 0.015 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.663292e-01 0.015 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.666716e-01 0.015 0 0
Viral mRNA Translation R-HSA-192823 9.669555e-01 0.015 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.681409e-01 0.014 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.685782e-01 0.014 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.689635e-01 0.014 0 0
G-protein activation R-HSA-202040 9.689635e-01 0.014 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.689635e-01 0.014 0 0
Signalling to RAS R-HSA-167044 9.689635e-01 0.014 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.689635e-01 0.014 0 0
Early Phase of HIV Life Cycle R-HSA-162594 9.689635e-01 0.014 0 0
Proteasome assembly R-HSA-9907900 9.691703e-01 0.014 0 0
DAP12 interactions R-HSA-2172127 9.691703e-01 0.014 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.696845e-01 0.013 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.696845e-01 0.013 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.696845e-01 0.013 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.709570e-01 0.013 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.714477e-01 0.013 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 9.728469e-01 0.012 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.728469e-01 0.012 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.728469e-01 0.012 0 0
Glutathione synthesis and recycling R-HSA-174403 9.728469e-01 0.012 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 9.729208e-01 0.012 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.729208e-01 0.012 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.729208e-01 0.012 0 0
Regulation of CDH1 Function R-HSA-9764561 9.735388e-01 0.012 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.748197e-01 0.011 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.758221e-01 0.011 0 0
PERK regulates gene expression R-HSA-381042 9.758221e-01 0.011 0 0
Regulation of Apoptosis R-HSA-169911 9.758221e-01 0.011 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.762446e-01 0.010 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.762446e-01 0.010 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.762446e-01 0.010 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.762446e-01 0.010 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.762446e-01 0.010 0 0
Signaling by KIT in disease R-HSA-9669938 9.762446e-01 0.010 0 0
LDL clearance R-HSA-8964038 9.762446e-01 0.010 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.762446e-01 0.010 0 0
Neddylation R-HSA-8951664 9.763823e-01 0.010 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.764689e-01 0.010 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.769290e-01 0.010 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.772611e-01 0.010 0 0
Synthesis of PC R-HSA-1483191 9.772611e-01 0.010 0 0
Peroxisomal protein import R-HSA-9033241 9.780696e-01 0.010 0 0
Regulation of beta-cell development R-HSA-186712 9.780696e-01 0.010 0 0
HCMV Early Events R-HSA-9609690 9.780719e-01 0.010 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.784215e-01 0.009 0 0
GPVI-mediated activation cascade R-HSA-114604 9.784215e-01 0.009 0 0
Stimuli-sensing channels R-HSA-2672351 9.785394e-01 0.009 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 9.789860e-01 0.009 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.792174e-01 0.009 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.797133e-01 0.009 0 0
GABA receptor activation R-HSA-977443 9.800507e-01 0.009 0 0
Interferon Signaling R-HSA-913531 9.804415e-01 0.009 0 0
Degradation of DVL R-HSA-4641258 9.807491e-01 0.008 0 0
Cleavage of the damaged purine R-HSA-110331 9.807491e-01 0.008 0 0
NCAM1 interactions R-HSA-419037 9.807491e-01 0.008 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 9.814418e-01 0.008 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.814843e-01 0.008 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.816574e-01 0.008 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 9.818182e-01 0.008 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.818182e-01 0.008 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.818182e-01 0.008 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.818182e-01 0.008 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.818182e-01 0.008 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.818182e-01 0.008 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.818182e-01 0.008 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.818182e-01 0.008 0 0
Interleukin-6 family signaling R-HSA-6783589 9.818182e-01 0.008 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.822610e-01 0.008 0 0
Protein folding R-HSA-391251 9.822610e-01 0.008 0 0
Developmental Cell Lineages R-HSA-9734767 9.825959e-01 0.008 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.828323e-01 0.008 0 0
Depurination R-HSA-73927 9.828323e-01 0.008 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.828323e-01 0.008 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.835167e-01 0.007 0 0
G protein gated Potassium channels R-HSA-1296059 9.840937e-01 0.007 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.840937e-01 0.007 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.840937e-01 0.007 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 9.840937e-01 0.007 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.840937e-01 0.007 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.840937e-01 0.007 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.840937e-01 0.007 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.846958e-01 0.007 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.849514e-01 0.007 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.849514e-01 0.007 0 0
The phototransduction cascade R-HSA-2514856 9.849514e-01 0.007 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.850643e-01 0.007 0 0
HCMV Late Events R-HSA-9610379 9.856963e-01 0.006 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.860846e-01 0.006 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.860846e-01 0.006 0 0
Attachment of bacteria to epithelial cells R-HSA-9638630 9.860846e-01 0.006 0 0
Urea cycle R-HSA-70635 9.860846e-01 0.006 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.860846e-01 0.006 0 0
Generation of second messenger molecules R-HSA-202433 9.863619e-01 0.006 0 0
Glycogen metabolism R-HSA-8982491 9.863619e-01 0.006 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.863619e-01 0.006 0 0
Cellular response to chemical stress R-HSA-9711123 9.865629e-01 0.006 0 0
XBP1(S) activates chaperone genes R-HSA-381038 9.869698e-01 0.006 0 0
Cytokine Signaling in Immune system R-HSA-1280215 9.877104e-01 0.005 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.878263e-01 0.005 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 9.878263e-01 0.005 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.878263e-01 0.005 0 0
Triglyceride biosynthesis R-HSA-75109 9.878263e-01 0.005 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.878263e-01 0.005 0 0
Synthesis of PE R-HSA-1483213 9.878263e-01 0.005 0 0
Insulin processing R-HSA-264876 9.878263e-01 0.005 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.878508e-01 0.005 0 0
Potassium Channels R-HSA-1296071 9.882206e-01 0.005 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.883490e-01 0.005 0 0
Platelet homeostasis R-HSA-418346 9.885949e-01 0.005 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.887775e-01 0.005 0 0
Ion channel transport R-HSA-983712 9.890506e-01 0.005 0 0
Heme biosynthesis R-HSA-189451 9.891807e-01 0.005 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.891807e-01 0.005 0 0
Insulin receptor recycling R-HSA-77387 9.893502e-01 0.005 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.893502e-01 0.005 0 0
Iron assimilation using enterobactin R-HSA-9638334 9.893502e-01 0.005 0 0
Pyroptosis R-HSA-5620971 9.893502e-01 0.005 0 0
Nicotinate metabolism R-HSA-196807 9.898543e-01 0.004 0 0
GABA B receptor activation R-HSA-977444 9.903682e-01 0.004 0 0
Activation of GABAB receptors R-HSA-991365 9.903682e-01 0.004 0 0
Thyroxine biosynthesis R-HSA-209968 9.906834e-01 0.004 0 0
Regulation of gene expression in beta cells R-HSA-210745 9.906834e-01 0.004 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.906834e-01 0.004 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.906834e-01 0.004 0 0
Downstream TCR signaling R-HSA-202424 9.908094e-01 0.004 0 0
Base Excision Repair R-HSA-73884 9.908094e-01 0.004 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.914280e-01 0.004 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.914280e-01 0.004 0 0
Phospholipid metabolism R-HSA-1483257 9.915448e-01 0.004 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.917049e-01 0.004 0 0
TCR signaling R-HSA-202403 9.917380e-01 0.004 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.918497e-01 0.004 0 0
Neurotransmitter clearance R-HSA-112311 9.918497e-01 0.004 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.918497e-01 0.004 0 0
Synthesis of PA R-HSA-1483166 9.920035e-01 0.003 0 0
IRE1alpha activates chaperones R-HSA-381070 9.923009e-01 0.003 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.924565e-01 0.003 0 0
SLC transporter disorders R-HSA-5619102 9.926745e-01 0.003 0 0
Budding and maturation of HIV virion R-HSA-162588 9.928701e-01 0.003 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.928701e-01 0.003 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.928701e-01 0.003 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.935434e-01 0.003 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.937697e-01 0.003 0 0
Leishmania phagocytosis R-HSA-9664417 9.937697e-01 0.003 0 0
Parasite infection R-HSA-9664407 9.937697e-01 0.003 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.939683e-01 0.003 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.939683e-01 0.003 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.942014e-01 0.003 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.942014e-01 0.003 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.945438e-01 0.002 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.945438e-01 0.002 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.945438e-01 0.002 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.946381e-01 0.002 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.948220e-01 0.002 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.949470e-01 0.002 0 0
Transmission across Chemical Synapses R-HSA-112315 9.949601e-01 0.002 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.952270e-01 0.002 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.952270e-01 0.002 0 0
Metal ion SLC transporters R-HSA-425410 9.952348e-01 0.002 0 0
Protein localization R-HSA-9609507 9.952795e-01 0.002 0 0
Neuronal System R-HSA-112316 9.953797e-01 0.002 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.954329e-01 0.002 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.955165e-01 0.002 0 0
Muscle contraction R-HSA-397014 9.956144e-01 0.002 0 0
Gap junction trafficking and regulation R-HSA-157858 9.957662e-01 0.002 0 0
Complex I biogenesis R-HSA-6799198 9.958083e-01 0.002 0 0
eNOS activation R-HSA-203615 9.958247e-01 0.002 0 0
Signal amplification R-HSA-392518 9.958247e-01 0.002 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.958247e-01 0.002 0 0
Hyaluronan metabolism R-HSA-2142845 9.958247e-01 0.002 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.958247e-01 0.002 0 0
Platelet degranulation R-HSA-114608 9.961242e-01 0.002 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.961279e-01 0.002 0 0
Regulation of insulin secretion R-HSA-422356 9.962671e-01 0.002 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.963476e-01 0.002 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.963476e-01 0.002 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.963476e-01 0.002 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 9.966293e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.966350e-01 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 9.966350e-01 0.001 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.967550e-01 0.001 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.968552e-01 0.001 0 0
Interferon gamma signaling R-HSA-877300 9.969922e-01 0.001 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.970348e-01 0.001 0 0
Adaptive Immune System R-HSA-1280218 9.971597e-01 0.001 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.972052e-01 0.001 0 0
Voltage gated Potassium channels R-HSA-1296072 9.972052e-01 0.001 0 0
Metabolism of folate and pterines R-HSA-196757 9.972052e-01 0.001 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.972928e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.972928e-01 0.001 0 0
Smooth Muscle Contraction R-HSA-445355 9.973680e-01 0.001 0 0
Biofilm formation R-HSA-9931953 9.975552e-01 0.001 0 0
Elastic fibre formation R-HSA-1566948 9.975552e-01 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 9.978559e-01 0.001 0 0
Pentose phosphate pathway R-HSA-71336 9.978615e-01 0.001 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.978615e-01 0.001 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.978731e-01 0.001 0 0
COPII-mediated vesicle transport R-HSA-204005 9.980557e-01 0.001 0 0
Mitochondrial protein degradation R-HSA-9837999 9.980727e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.982598e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.983696e-01 0.001 0 0
Vesicle-mediated transport R-HSA-5653656 9.984717e-01 0.001 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.985543e-01 0.001 0 0
Intra-Golgi traffic R-HSA-6811438 9.985687e-01 0.001 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.986775e-01 0.001 0 0
HCMV Infection R-HSA-9609646 9.986981e-01 0.001 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.987480e-01 0.001 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.988065e-01 0.001 0 0
RAB geranylgeranylation R-HSA-8873719 9.988639e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.988639e-01 0.000 0 0
Protein ubiquitination R-HSA-8852135 9.988862e-01 0.000 0 0
Defensins R-HSA-1461973 9.989049e-01 0.000 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.989049e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.989083e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.989932e-01 0.000 0 0
Interleukin-12 signaling R-HSA-9020591 9.990044e-01 0.000 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.990142e-01 0.000 0 0
ER-Phagosome pathway R-HSA-1236974 9.990364e-01 0.000 0 0
ABC-family proteins mediated transport R-HSA-382556 9.990416e-01 0.000 0 0
Gap junction trafficking R-HSA-190828 9.990421e-01 0.000 0 0
Surfactant metabolism R-HSA-5683826 9.990421e-01 0.000 0 0
Methylation R-HSA-156581 9.990421e-01 0.000 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.990623e-01 0.000 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 9.991336e-01 0.000 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.991622e-01 0.000 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.991622e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.992051e-01 0.000 0 0
Integrin cell surface interactions R-HSA-216083 9.992051e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.992051e-01 0.000 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.992672e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.992900e-01 0.000 0 0
Intraflagellar transport R-HSA-5620924 9.994394e-01 0.000 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.994394e-01 0.000 0 0
Gluconeogenesis R-HSA-70263 9.994394e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.994437e-01 0.000 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.994571e-01 0.000 0 0
rRNA processing R-HSA-72312 9.994624e-01 0.000 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.995096e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.995096e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.995141e-01 0.000 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.995263e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.995699e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.996178e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.996249e-01 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 9.996666e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.997019e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.997019e-01 0.000 0 0
Interleukin-12 family signaling R-HSA-447115 9.997455e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.997805e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.998080e-01 0.000 0 0
Digestion R-HSA-8935690 9.998080e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.998176e-01 0.000 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.998727e-01 0.000 0 0
tRNA Aminoacylation R-HSA-379724 9.998877e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.998877e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999175e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999249e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999252e-01 0.000 0 0
Parasitic Infection Pathways R-HSA-9824443 9.999353e-01 0.000 0 0
Leishmania infection R-HSA-9658195 9.999353e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999400e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999425e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.999433e-01 0.000 0 0
Hemostasis R-HSA-109582 9.999464e-01 0.000 0 0
Neutrophil degranulation R-HSA-6798695 9.999511e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.999677e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999678e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.999743e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999743e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999775e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999803e-01 0.000 0 0
Viral Infection Pathways R-HSA-9824446 9.999872e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999892e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999908e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999908e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999912e-01 0.000 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.999928e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999928e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999932e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999933e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.999933e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999937e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999950e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999958e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999962e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999970e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.999973e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999974e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999974e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999980e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999984e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999986e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999989e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999994e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999994e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999995e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999995e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999996e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999997e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999997e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999998e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999998e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999999e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999999e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999999e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999999e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
G alpha (i) signalling events R-HSA-418594 1.000000e+00 0.000 0 0
Immune System R-HSA-168256 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Translation R-HSA-72766 1.000000e+00 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Innate Immune System R-HSA-168249 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle, Mitotic R-HSA-69278 4.368363e-10 9.360 0 0
Cell Cycle R-HSA-1640170 5.044032e-10 9.297 0 0
Cellular response to heat stress R-HSA-3371556 1.186900e-09 8.926 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.724867e-09 8.763 0 0
M Phase R-HSA-68886 7.471011e-08 7.127 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.721317e-07 6.764 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.153531e-07 6.667 0 0
mRNA Splicing R-HSA-72172 2.752617e-07 6.560 0 0
HSF1-dependent transactivation R-HSA-3371571 6.125546e-07 6.213 0 0
Metabolism of RNA R-HSA-8953854 7.652215e-07 6.116 0 0
Mitotic Prometaphase R-HSA-68877 9.109215e-07 6.041 0 0
Mitotic Anaphase R-HSA-68882 1.111761e-06 5.954 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.242044e-06 5.906 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.686053e-06 5.571 0 0
Apoptotic execution phase R-HSA-75153 2.752667e-06 5.560 0 0
Attenuation phase R-HSA-3371568 7.460516e-06 5.127 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.171184e-05 4.931 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.152250e-05 4.938 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.373656e-05 4.862 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.903243e-05 4.721 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.903243e-05 4.721 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.877673e-05 4.726 0 0
Chromatin organization R-HSA-4839726 2.898879e-05 4.538 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.241096e-05 4.489 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 3.900601e-05 4.409 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 3.900601e-05 4.409 0 0
Signaling downstream of RAS mutants R-HSA-9649948 3.900601e-05 4.409 0 0
Signaling by RAS mutants R-HSA-6802949 3.900601e-05 4.409 0 0
Oncogenic MAPK signaling R-HSA-6802957 4.661181e-05 4.332 0 0
Chromatin modifying enzymes R-HSA-3247509 6.477565e-05 4.189 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 8.268648e-05 4.083 0 0
Cellular responses to stress R-HSA-2262752 8.687300e-05 4.061 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 9.283910e-05 4.032 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.019856e-04 3.991 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.129491e-04 3.947 0 0
Separation of Sister Chromatids R-HSA-2467813 1.311980e-04 3.882 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.331860e-04 3.876 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.358438e-04 3.867 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.673461e-04 3.776 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.922121e-04 3.716 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.053152e-04 3.688 0 0
MTOR signalling R-HSA-165159 2.049637e-04 3.688 0 0
Signal Transduction R-HSA-162582 2.317687e-04 3.635 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 3.120396e-04 3.506 0 0
Cellular responses to stimuli R-HSA-8953897 3.735710e-04 3.428 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 3.811299e-04 3.419 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.509013e-04 3.346 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 4.526817e-04 3.344 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 4.752539e-04 3.323 0 0
Smooth Muscle Contraction R-HSA-445355 4.778163e-04 3.321 0 0
MAP2K and MAPK activation R-HSA-5674135 5.588579e-04 3.253 0 0
Mitotic Prophase R-HSA-68875 5.423094e-04 3.266 0 0
Programmed Cell Death R-HSA-5357801 6.706667e-04 3.173 0 0
Interleukin-12 signaling R-HSA-9020591 6.834835e-04 3.165 0 0
Clathrin-mediated endocytosis R-HSA-8856828 7.614397e-04 3.118 0 0
Signaling by Hippo R-HSA-2028269 9.113786e-04 3.040 0 0
Apoptosis R-HSA-109581 9.760768e-04 3.011 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.032423e-03 2.986 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.088226e-03 2.963 0 0
Nervous system development R-HSA-9675108 1.094709e-03 2.961 0 0
Axon guidance R-HSA-422475 1.129838e-03 2.947 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.337887e-03 2.874 0 0
Nuclear import of Rev protein R-HSA-180746 1.320298e-03 2.879 0 0
Recycling pathway of L1 R-HSA-437239 1.559070e-03 2.807 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.672824e-03 2.777 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.741914e-03 2.759 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.817257e-03 2.741 0 0
tRNA processing in the nucleus R-HSA-6784531 1.833333e-03 2.737 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.090608e-03 2.680 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.090608e-03 2.680 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.035873e-03 2.691 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.035873e-03 2.691 0 0
HSF1 activation R-HSA-3371511 1.906650e-03 2.720 0 0
Signaling by EGFR R-HSA-177929 2.127613e-03 2.672 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.963847e-03 2.707 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.270785e-03 2.644 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.951868e-03 2.530 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.951868e-03 2.530 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.793084e-03 2.554 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.951868e-03 2.530 0 0
Interleukin-12 family signaling R-HSA-447115 2.874168e-03 2.541 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.206590e-03 2.494 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.025599e-03 2.519 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.307712e-03 2.480 0 0
Membrane Trafficking R-HSA-199991 3.355605e-03 2.474 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.519339e-03 2.454 0 0
Signaling by ERBB2 R-HSA-1227986 3.620605e-03 2.441 0 0
ISG15 antiviral mechanism R-HSA-1169408 3.678157e-03 2.434 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.712718e-03 2.430 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.712718e-03 2.430 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.926845e-03 2.406 0 0
RAF activation R-HSA-5673000 4.170084e-03 2.380 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 4.329831e-03 2.364 0 0
Autophagy R-HSA-9612973 4.378869e-03 2.359 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 4.476836e-03 2.349 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 4.912241e-03 2.309 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 4.666393e-03 2.331 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.881519e-03 2.311 0 0
Macroautophagy R-HSA-1632852 4.694955e-03 2.328 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 4.919337e-03 2.308 0 0
MITF-M-dependent gene expression R-HSA-9856651 5.266130e-03 2.279 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 5.474789e-03 2.262 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.863077e-03 2.232 0 0
Regulation of KIT signaling R-HSA-1433559 5.863077e-03 2.232 0 0
Estrogen-dependent gene expression R-HSA-9018519 6.103255e-03 2.214 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 6.134601e-03 2.212 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 6.483323e-03 2.188 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 6.687476e-03 2.175 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 6.828087e-03 2.166 0 0
Influenza Infection R-HSA-168255 6.957919e-03 2.158 0 0
Selective autophagy R-HSA-9663891 7.021935e-03 2.154 0 0
AURKA Activation by TPX2 R-HSA-8854518 7.362637e-03 2.133 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 7.514199e-03 2.124 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 7.538585e-03 2.123 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 7.598754e-03 2.119 0 0
Signaling by VEGF R-HSA-194138 8.219632e-03 2.085 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 8.328160e-03 2.079 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 8.328160e-03 2.079 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 7.772668e-03 2.109 0 0
mRNA 3'-end processing R-HSA-72187 8.353234e-03 2.078 0 0
Centrosome maturation R-HSA-380287 8.403084e-03 2.076 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 8.544886e-03 2.068 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 8.834260e-03 2.054 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 8.951340e-03 2.048 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 9.875953e-03 2.005 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.129240e-02 1.947 0 0
Aggrephagy R-HSA-9646399 1.029708e-02 1.987 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.076646e-02 1.968 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.122967e-02 1.950 0 0
Cell Cycle Checkpoints R-HSA-69620 1.091052e-02 1.962 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.146415e-02 1.941 0 0
Signaling by ALK in cancer R-HSA-9700206 1.146415e-02 1.941 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.188056e-02 1.925 0 0
Gene expression (Transcription) R-HSA-74160 1.201394e-02 1.920 0 0
Cell-Cell communication R-HSA-1500931 1.202015e-02 1.920 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.224496e-02 1.912 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.224496e-02 1.912 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.240683e-02 1.906 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.390508e-02 1.857 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.266640e-02 1.897 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.266640e-02 1.897 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.391346e-02 1.857 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.391346e-02 1.857 0 0
mTORC1-mediated signalling R-HSA-166208 1.344968e-02 1.871 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.367998e-02 1.864 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.269623e-02 1.896 0 0
Late endosomal microautophagy R-HSA-9615710 1.398813e-02 1.854 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.464419e-02 1.834 0 0
Adherens junctions interactions R-HSA-418990 1.491701e-02 1.826 0 0
S Phase R-HSA-69242 1.508322e-02 1.822 0 0
RUNX2 regulates bone development R-HSA-8941326 1.590992e-02 1.798 0 0
Regulation of gap junction activity R-HSA-191650 1.679051e-02 1.775 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.679051e-02 1.775 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 1.732183e-02 1.761 0 0
Formation of annular gap junctions R-HSA-196025 1.732183e-02 1.761 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.732183e-02 1.761 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.732183e-02 1.761 0 0
Ephrin signaling R-HSA-3928664 1.773826e-02 1.751 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.814146e-02 1.741 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.773826e-02 1.751 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.679051e-02 1.775 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.622433e-02 1.790 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.732183e-02 1.761 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.818478e-02 1.740 0 0
Cell junction organization R-HSA-446728 1.822520e-02 1.739 0 0
Formation of axial mesoderm R-HSA-9796292 1.867037e-02 1.729 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.867037e-02 1.729 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.867037e-02 1.729 0 0
EGFR downregulation R-HSA-182971 1.878617e-02 1.726 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 2.008312e-02 1.697 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.008312e-02 1.697 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.015334e-02 1.696 0 0
Cellular Senescence R-HSA-2559583 2.150999e-02 1.667 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.292042e-02 1.640 0 0
Lipophagy R-HSA-9613354 2.292042e-02 1.640 0 0
Gap junction degradation R-HSA-190873 2.292042e-02 1.640 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.292042e-02 1.640 0 0
Nuclear RNA decay R-HSA-9930044 2.465791e-02 1.608 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.346142e-02 1.630 0 0
Signaling by TGFBR3 R-HSA-9839373 2.417783e-02 1.617 0 0
ESR-mediated signaling R-HSA-8939211 2.417368e-02 1.617 0 0
Unwinding of DNA R-HSA-176974 2.292042e-02 1.640 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 2.164198e-02 1.665 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.222545e-02 1.653 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.354005e-02 1.628 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.465791e-02 1.608 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.417783e-02 1.617 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.500440e-02 1.602 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.500440e-02 1.602 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.532122e-02 1.597 0 0
Formation of definitive endoderm R-HSA-9823730 2.532122e-02 1.597 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.551090e-02 1.593 0 0
HIV Life Cycle R-HSA-162587 2.592991e-02 1.586 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.631264e-02 1.580 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.642780e-02 1.578 0 0
Post NMDA receptor activation events R-HSA-438064 2.677959e-02 1.572 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.694799e-02 1.569 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.802888e-02 1.552 0 0
DCC mediated attractive signaling R-HSA-418885 2.828714e-02 1.548 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.828714e-02 1.548 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.950199e-02 1.530 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.952997e-02 1.530 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.981546e-02 1.526 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.501411e-02 1.456 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 3.408446e-02 1.467 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 3.368418e-02 1.473 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.480272e-02 1.458 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 3.408446e-02 1.467 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 3.499971e-02 1.456 0 0
Signaling by TGFB family members R-HSA-9006936 3.063682e-02 1.514 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 3.501411e-02 1.456 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 3.118748e-02 1.506 0 0
Regulation of CDH1 Function R-HSA-9764561 3.277024e-02 1.485 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 3.368418e-02 1.473 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.480272e-02 1.458 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.591305e-02 1.445 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 3.668451e-02 1.436 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 3.792257e-02 1.421 0 0
Metabolism of non-coding RNA R-HSA-194441 3.926157e-02 1.406 0 0
snRNP Assembly R-HSA-191859 3.926157e-02 1.406 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 4.957252e-02 1.305 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 4.957252e-02 1.305 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 4.957252e-02 1.305 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 4.957252e-02 1.305 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 4.957252e-02 1.305 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 4.957252e-02 1.305 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 4.957252e-02 1.305 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 4.957252e-02 1.305 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 4.957252e-02 1.305 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 4.957252e-02 1.305 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 4.957252e-02 1.305 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 4.957252e-02 1.305 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 4.678344e-02 1.330 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 4.774795e-02 1.321 0 0
Activation of the pre-replicative complex R-HSA-68962 4.343493e-02 1.362 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 4.400813e-02 1.356 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 4.814627e-02 1.317 0 0
Meiotic synapsis R-HSA-1221632 4.814627e-02 1.317 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.478919e-02 1.349 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 4.709006e-02 1.327 0 0
HCMV Early Events R-HSA-9609690 4.771350e-02 1.321 0 0
Developmental Cell Lineages R-HSA-9734767 4.880812e-02 1.312 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 4.678344e-02 1.330 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 4.678344e-02 1.330 0 0
EPH-Ephrin signaling R-HSA-2682334 4.159849e-02 1.381 0 0
Intracellular signaling by second messengers R-HSA-9006925 4.944597e-02 1.306 0 0
RMTs methylate histone arginines R-HSA-3214858 4.471753e-02 1.350 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 4.787782e-02 1.320 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 4.570119e-02 1.340 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 4.467203e-02 1.350 0 0
RNA Polymerase II Transcription R-HSA-73857 4.604750e-02 1.337 0 0
Developmental Biology R-HSA-1266738 4.292499e-02 1.367 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.570119e-02 1.340 0 0
Activation of BH3-only proteins R-HSA-114452 4.343493e-02 1.362 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 4.892758e-02 1.310 0 0
L1CAM interactions R-HSA-373760 4.494715e-02 1.347 0 0
Translation initiation complex formation R-HSA-72649 5.253763e-02 1.280 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 5.285544e-02 1.277 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 5.422683e-02 1.266 0 0
Formation of a pool of free 40S subunits R-HSA-72689 5.425817e-02 1.266 0 0
Semaphorin interactions R-HSA-373755 5.481437e-02 1.261 0 0
DNA strand elongation R-HSA-69190 5.484184e-02 1.261 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.532859e-02 1.257 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 5.532859e-02 1.257 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 5.532859e-02 1.257 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 5.588815e-02 1.253 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 5.632479e-02 1.249 0 0
HDACs deacetylate histones R-HSA-3214815 5.718660e-02 1.243 0 0
TGFBR3 expression R-HSA-9839394 5.993230e-02 1.222 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 7.317406e-02 1.136 0 0
MET interacts with TNS proteins R-HSA-8875513 7.317406e-02 1.136 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 7.317406e-02 1.136 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 7.317406e-02 1.136 0 0
Disinhibition of SNARE formation R-HSA-114516 6.024187e-02 1.220 0 0
Type I hemidesmosome assembly R-HSA-446107 7.529301e-02 1.123 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 6.596058e-02 1.181 0 0
Negative regulation of MET activity R-HSA-6807004 7.351435e-02 1.134 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 6.754554e-02 1.170 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 6.795418e-02 1.168 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 6.209694e-02 1.207 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 6.157151e-02 1.211 0 0
Integrin signaling R-HSA-354192 6.118294e-02 1.213 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 6.676291e-02 1.175 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 6.024187e-02 1.220 0 0
Myogenesis R-HSA-525793 6.754554e-02 1.170 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 6.209694e-02 1.207 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.529301e-02 1.123 0 0
Gap junction trafficking and regulation R-HSA-157858 7.042218e-02 1.152 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 6.118294e-02 1.213 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.024187e-02 1.220 0 0
Meiosis R-HSA-1500620 7.460379e-02 1.127 0 0
Interferon Signaling R-HSA-913531 7.233265e-02 1.141 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 6.754554e-02 1.170 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 6.676291e-02 1.175 0 0
Signaling by NOTCH1 R-HSA-1980143 7.458063e-02 1.127 0 0
Protein-protein interactions at synapses R-HSA-6794362 7.460379e-02 1.127 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 6.209694e-02 1.207 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 7.317406e-02 1.136 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 6.024187e-02 1.220 0 0
G2/M Transition R-HSA-69275 7.127920e-02 1.147 0 0
Cell-cell junction organization R-HSA-421270 6.512543e-02 1.186 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 7.529301e-02 1.123 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 6.596058e-02 1.181 0 0
Signaling by ROBO receptors R-HSA-376176 6.459489e-02 1.190 0 0
Gene Silencing by RNA R-HSA-211000 6.862480e-02 1.164 0 0
Mitotic G2-G2/M phases R-HSA-453274 7.746700e-02 1.111 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 7.994922e-02 1.097 0 0
Ca-dependent events R-HSA-111996 7.994922e-02 1.097 0 0
Late Phase of HIV Life Cycle R-HSA-162599 8.170948e-02 1.088 0 0
ERK/MAPK targets R-HSA-198753 8.349651e-02 1.078 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 8.349651e-02 1.078 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 8.440396e-02 1.074 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 8.463599e-02 1.072 0 0
RNA Polymerase I Transcription R-HSA-73864 8.498134e-02 1.071 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 8.708252e-02 1.060 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 9.958943e-02 1.002 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 9.958943e-02 1.002 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 9.958943e-02 1.002 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 9.958943e-02 1.002 0 0
WNT mediated activation of DVL R-HSA-201688 9.182155e-02 1.037 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.096991e-01 0.960 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 9.013293e-02 1.045 0 0
FGFR2 alternative splicing R-HSA-6803529 1.054720e-01 0.977 0 0
Notch-HLH transcription pathway R-HSA-350054 1.054720e-01 0.977 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.054720e-01 0.977 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.033073e-01 0.986 0 0
MET promotes cell motility R-HSA-8875878 1.082452e-01 0.966 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.106213e-01 0.956 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.106213e-01 0.956 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 9.648726e-02 1.016 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.124299e-01 0.949 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 8.994877e-02 1.046 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 8.994877e-02 1.046 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.124299e-01 0.949 0 0
PKR-mediated signaling R-HSA-9833482 9.624250e-02 1.017 0 0
Signaling by MET R-HSA-6806834 9.624250e-02 1.017 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 9.091312e-02 1.041 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 1.033073e-01 0.986 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.096991e-01 0.960 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 9.013293e-02 1.045 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.024220e-01 0.990 0 0
Regulation of CDH11 function R-HSA-9762292 1.096991e-01 0.960 0 0
HATs acetylate histones R-HSA-3214847 1.157308e-01 0.937 0 0
Trafficking of AMPA receptors R-HSA-399719 1.135363e-01 0.945 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.134037e-01 0.945 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 9.358322e-02 1.029 0 0
Neurexins and neuroligins R-HSA-6794361 8.950845e-02 1.048 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 1.054720e-01 0.977 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 9.358322e-02 1.029 0 0
HCMV Infection R-HSA-9609646 8.961288e-02 1.048 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.113608e-01 0.953 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.033565e-01 0.986 0 0
Signaling by PTK6 R-HSA-8848021 1.039624e-01 0.983 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.039624e-01 0.983 0 0
Vesicle-mediated transport R-HSA-5653656 9.190042e-02 1.037 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 9.958943e-02 1.002 0 0
Calmodulin induced events R-HSA-111933 9.085312e-02 1.042 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.096991e-01 0.960 0 0
CaM pathway R-HSA-111997 9.085312e-02 1.042 0 0
DAG and IP3 signaling R-HSA-1489509 1.024220e-01 0.990 0 0
Netrin-1 signaling R-HSA-373752 9.457435e-02 1.024 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 9.717393e-02 1.012 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 9.700892e-02 1.013 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.099422e-01 0.959 0 0
Signaling by NTRKs R-HSA-166520 1.065403e-01 0.972 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 8.796756e-02 1.056 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.109792e-01 0.955 0 0
Regulation of TP53 Activity R-HSA-5633007 1.165648e-01 0.933 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.052669e-01 0.978 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.167642e-01 0.933 0 0
Syndecan interactions R-HSA-3000170 1.174236e-01 0.930 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.175611e-01 0.930 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.175611e-01 0.930 0 0
Disorders of Developmental Biology R-HSA-9675151 1.179214e-01 0.928 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.179214e-01 0.928 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.179214e-01 0.928 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.186128e-01 0.926 0 0
IRE1alpha activates chaperones R-HSA-381070 1.186128e-01 0.926 0 0
NRAGE signals death through JNK R-HSA-193648 1.192493e-01 0.924 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.213402e-01 0.916 0 0
Glycolysis R-HSA-70171 1.217220e-01 0.915 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.234113e-01 0.909 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.249879e-01 0.903 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.272785e-01 0.895 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.280534e-01 0.893 0 0
Co-stimulation by CD28 R-HSA-389356 1.280534e-01 0.893 0 0
NGF-stimulated transcription R-HSA-9031628 1.280534e-01 0.893 0 0
IRS activation R-HSA-74713 1.281740e-01 0.892 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.281740e-01 0.892 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.281740e-01 0.892 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 1.281740e-01 0.892 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 1.281740e-01 0.892 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 1.287891e-01 0.890 0 0
PECAM1 interactions R-HSA-210990 1.287891e-01 0.890 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.287891e-01 0.890 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 1.287891e-01 0.890 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.299837e-01 0.886 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.311082e-01 0.882 0 0
UCH proteinases R-HSA-5689603 1.311082e-01 0.882 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.319775e-01 0.880 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.330479e-01 0.876 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.354509e-01 0.868 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.354509e-01 0.868 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.354509e-01 0.868 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.359420e-01 0.867 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.372723e-01 0.862 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.407868e-01 0.851 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.423732e-01 0.847 0 0
HDMs demethylate histones R-HSA-3214842 1.431226e-01 0.844 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.460732e-01 0.835 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.621133e-01 0.790 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 1.621133e-01 0.790 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.621133e-01 0.790 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.621133e-01 0.790 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.621133e-01 0.790 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.621133e-01 0.790 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.621133e-01 0.790 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.621133e-01 0.790 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.583719e-01 0.800 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.583719e-01 0.800 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 1.583719e-01 0.800 0 0
PDE3B signalling R-HSA-165160 1.583719e-01 0.800 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.583719e-01 0.800 0 0
PKB-mediated events R-HSA-109703 1.583719e-01 0.800 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 1.583719e-01 0.800 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 1.897059e-01 0.722 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 1.489506e-01 0.827 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.217676e-01 0.654 0 0
IFNG signaling activates MAPKs R-HSA-9732724 2.217676e-01 0.654 0 0
SOS-mediated signalling R-HSA-112412 2.217676e-01 0.654 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.700417e-01 0.769 0 0
Pervasive developmental disorders R-HSA-9005895 1.700417e-01 0.769 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.700417e-01 0.769 0 0
Disorders of Nervous System Development R-HSA-9697154 1.700417e-01 0.769 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.700417e-01 0.769 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 2.144536e-01 0.669 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.144536e-01 0.669 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.826480e-01 0.738 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.710052e-01 0.767 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.710052e-01 0.767 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 2.185884e-01 0.660 0 0
HIV elongation arrest and recovery R-HSA-167287 1.856776e-01 0.731 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.856776e-01 0.731 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 2.007869e-01 0.697 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.845794e-01 0.734 0 0
Nucleotide Excision Repair R-HSA-5696398 1.613021e-01 0.792 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 2.162939e-01 0.665 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 1.826480e-01 0.738 0 0
Chromosome Maintenance R-HSA-73886 2.216287e-01 0.654 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.178925e-01 0.662 0 0
Repression of WNT target genes R-HSA-4641265 1.700417e-01 0.769 0 0
GAB1 signalosome R-HSA-180292 1.489194e-01 0.827 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 2.217676e-01 0.654 0 0
Peptide chain elongation R-HSA-156902 1.574090e-01 0.803 0 0
CREB phosphorylation R-HSA-199920 1.897059e-01 0.722 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.489506e-01 0.827 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.716885e-01 0.765 0 0
Signaling by NOTCH3 R-HSA-9012852 1.990276e-01 0.701 0 0
Activation and oligomerization of BAK protein R-HSA-111452 1.621133e-01 0.790 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.583719e-01 0.800 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 1.489194e-01 0.827 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.489194e-01 0.827 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 1.587237e-01 0.799 0 0
MAP kinase activation R-HSA-450294 1.630066e-01 0.788 0 0
Gap junction trafficking R-HSA-190828 1.814591e-01 0.741 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 1.654743e-01 0.781 0 0
PTEN Regulation R-HSA-6807070 1.574608e-01 0.803 0 0
Signaling by SCF-KIT R-HSA-1433557 1.699244e-01 0.770 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.478727e-01 0.830 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.772895e-01 0.751 0 0
HIV Infection R-HSA-162906 1.572567e-01 0.803 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.814591e-01 0.741 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.766370e-01 0.753 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 1.621133e-01 0.790 0 0
Inhibition of PKR R-HSA-169131 1.621133e-01 0.790 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 2.217676e-01 0.654 0 0
Early Phase of HIV Life Cycle R-HSA-162594 2.003749e-01 0.698 0 0
Circadian clock R-HSA-9909396 1.698907e-01 0.770 0 0
MAPK family signaling cascades R-HSA-5683057 1.834471e-01 0.736 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.587709e-01 0.799 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.826367e-01 0.738 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.583719e-01 0.800 0 0
Reproduction R-HSA-1474165 1.571753e-01 0.804 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.933107e-01 0.714 0 0
Activation of RAC1 R-HSA-428540 1.489506e-01 0.827 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 2.217676e-01 0.654 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.217676e-01 0.654 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.168518e-01 0.664 0 0
Death Receptor Signaling R-HSA-73887 1.945664e-01 0.711 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 2.217676e-01 0.654 0 0
Signal regulatory protein family interactions R-HSA-391160 2.144536e-01 0.669 0 0
Inositol phosphate metabolism R-HSA-1483249 2.147911e-01 0.668 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.185884e-01 0.660 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.478727e-01 0.830 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.249298e-01 0.648 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 2.253441e-01 0.647 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.330371e-01 0.633 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.330371e-01 0.633 0 0
Defective VWF binding to collagen type I R-HSA-9845622 2.330371e-01 0.633 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 2.330371e-01 0.633 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.330371e-01 0.633 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 2.330371e-01 0.633 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 2.330371e-01 0.633 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.330371e-01 0.633 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 2.979614e-01 0.526 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 2.979614e-01 0.526 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 2.979614e-01 0.526 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 2.979614e-01 0.526 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 2.979614e-01 0.526 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 2.979614e-01 0.526 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 2.979614e-01 0.526 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 2.979614e-01 0.526 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 2.979614e-01 0.526 0 0
Invadopodia formation R-HSA-8941237 3.573932e-01 0.447 0 0
Defective GSS causes GSS deficiency R-HSA-5579006 3.573932e-01 0.447 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 3.573932e-01 0.447 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 3.573932e-01 0.447 0 0
MET activates PTPN11 R-HSA-8865999 3.573932e-01 0.447 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 2.542098e-01 0.595 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 2.542098e-01 0.595 0 0
MET receptor recycling R-HSA-8875656 2.542098e-01 0.595 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 2.867386e-01 0.543 0 0
ALK mutants bind TKIs R-HSA-9700645 2.867386e-01 0.543 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.117970e-01 0.385 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.117970e-01 0.385 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.117970e-01 0.385 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.117970e-01 0.385 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.117970e-01 0.385 0 0
Processive synthesis on the lagging strand R-HSA-69183 2.375054e-01 0.624 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 3.191071e-01 0.496 0 0
Regulation of the apoptosome activity R-HSA-9627069 3.191071e-01 0.496 0 0
2-LTR circle formation R-HSA-164843 3.191071e-01 0.496 0 0
DNA replication initiation R-HSA-68952 3.191071e-01 0.496 0 0
Folding of actin by CCT/TriC R-HSA-390450 3.191071e-01 0.496 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.609515e-01 0.583 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.846730e-01 0.546 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 2.562094e-01 0.591 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.085591e-01 0.511 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.085591e-01 0.511 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 2.321586e-01 0.634 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.754862e-01 0.560 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 3.825761e-01 0.417 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 3.825761e-01 0.417 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 3.825761e-01 0.417 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.483405e-01 0.605 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.325068e-01 0.478 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 3.325068e-01 0.478 0 0
Striated Muscle Contraction R-HSA-390522 2.814932e-01 0.551 0 0
MET activates PTK2 signaling R-HSA-8874081 3.146577e-01 0.502 0 0
Regulation of signaling by CBL R-HSA-912631 3.564213e-01 0.448 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 3.564213e-01 0.448 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 4.133683e-01 0.384 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.133683e-01 0.384 0 0
Polymerase switching R-HSA-69091 4.133683e-01 0.384 0 0
Leading Strand Synthesis R-HSA-69109 4.133683e-01 0.384 0 0
Scavenging by Class F Receptors R-HSA-3000484 4.133683e-01 0.384 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.344327e-01 0.476 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.802161e-01 0.420 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 4.433748e-01 0.353 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 4.433748e-01 0.353 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.325950e-01 0.478 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.573144e-01 0.590 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 4.038128e-01 0.394 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 4.038128e-01 0.394 0 0
Lagging Strand Synthesis R-HSA-69186 4.038128e-01 0.394 0 0
Basigin interactions R-HSA-210991 4.038128e-01 0.394 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 4.038128e-01 0.394 0 0
DNA methylation R-HSA-5334118 3.740815e-01 0.427 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.291830e-01 0.483 0 0
Nucleosome assembly R-HSA-774815 3.291830e-01 0.483 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 3.446064e-01 0.463 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.938523e-01 0.405 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.938523e-01 0.405 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 4.271411e-01 0.369 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 4.271411e-01 0.369 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 2.598723e-01 0.585 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.844279e-01 0.415 0 0
HIV Transcription Elongation R-HSA-167169 4.017019e-01 0.396 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.017019e-01 0.396 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.017019e-01 0.396 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.397072e-01 0.620 0 0
Viral mRNA Translation R-HSA-192823 3.121093e-01 0.506 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 4.330524e-01 0.363 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 4.189197e-01 0.378 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 4.523977e-01 0.344 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 4.376421e-01 0.359 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 4.511117e-01 0.346 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.607307e-01 0.443 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 2.395415e-01 0.621 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 2.395415e-01 0.621 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 3.825761e-01 0.417 0 0
Formation of apoptosome R-HSA-111458 3.191071e-01 0.496 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.983834e-01 0.525 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 3.825761e-01 0.417 0 0
Integration of provirus R-HSA-162592 3.825761e-01 0.417 0 0
G0 and Early G1 R-HSA-1538133 4.330524e-01 0.363 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 3.146577e-01 0.502 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.349649e-01 0.629 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 2.867386e-01 0.543 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 3.191071e-01 0.496 0 0
Germ layer formation at gastrulation R-HSA-9754189 3.564213e-01 0.448 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.434342e-01 0.614 0 0
Adipogenesis R-HSA-9843745 3.243285e-01 0.489 0 0
PI3K/AKT activation R-HSA-198203 3.191071e-01 0.496 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 3.511095e-01 0.455 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 3.825761e-01 0.417 0 0
Protein folding R-HSA-391251 2.960070e-01 0.529 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 3.564213e-01 0.448 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 4.016806e-01 0.396 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.949894e-01 0.530 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 2.867386e-01 0.543 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 4.117970e-01 0.385 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.375054e-01 0.624 0 0
NF-kB is activated and signals survival R-HSA-209560 3.825761e-01 0.417 0 0
VLDLR internalisation and degradation R-HSA-8866427 4.133683e-01 0.384 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 3.769563e-01 0.424 0 0
Rab regulation of trafficking R-HSA-9007101 2.748692e-01 0.561 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.114808e-01 0.507 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 3.146577e-01 0.502 0 0
G alpha (12/13) signalling events R-HSA-416482 3.523584e-01 0.453 0 0
Long-term potentiation R-HSA-9620244 2.949894e-01 0.530 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 3.991988e-01 0.399 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.816043e-01 0.418 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.784579e-01 0.555 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.846730e-01 0.546 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 2.846730e-01 0.546 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 4.133683e-01 0.384 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 2.983834e-01 0.525 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 3.802161e-01 0.420 0 0
Defective pyroptosis R-HSA-9710421 2.986400e-01 0.525 0 0
Termination of translesion DNA synthesis R-HSA-5656169 3.740815e-01 0.427 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 2.931204e-01 0.533 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.455660e-01 0.610 0 0
Signaling by Nuclear Receptors R-HSA-9006931 4.455052e-01 0.351 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 4.433748e-01 0.353 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.575633e-01 0.589 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.575633e-01 0.589 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.575633e-01 0.589 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.575633e-01 0.589 0 0
Frs2-mediated activation R-HSA-170968 4.433748e-01 0.353 0 0
Cellular response to starvation R-HSA-9711097 3.906084e-01 0.408 0 0
Inhibition of nitric oxide production R-HSA-9636249 3.573932e-01 0.447 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 2.542098e-01 0.595 0 0
Interleukin-17 signaling R-HSA-448424 2.573144e-01 0.590 0 0
Eukaryotic Translation Termination R-HSA-72764 2.341102e-01 0.631 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.302577e-01 0.481 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.606660e-01 0.584 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 2.542098e-01 0.595 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.539978e-01 0.595 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 2.514147e-01 0.600 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.065921e-01 0.513 0 0
Protein ubiquitination R-HSA-8852135 4.519040e-01 0.345 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 2.867386e-01 0.543 0 0
Signaling by NOTCH4 R-HSA-9013694 4.387732e-01 0.358 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.375054e-01 0.624 0 0
Signaling by NOTCH R-HSA-157118 3.641272e-01 0.439 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 4.377783e-01 0.359 0 0
Cilium Assembly R-HSA-5617833 3.078689e-01 0.512 0 0
Signaling by WNT R-HSA-195721 3.855432e-01 0.414 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 2.330371e-01 0.633 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.330371e-01 0.633 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.330371e-01 0.633 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 2.979614e-01 0.526 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 2.979614e-01 0.526 0 0
MET activates STAT3 R-HSA-8875791 3.573932e-01 0.447 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 2.542098e-01 0.595 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 3.191071e-01 0.496 0 0
Bicarbonate transporters R-HSA-425381 3.511095e-01 0.455 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 3.344327e-01 0.476 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 4.271411e-01 0.369 0 0
Budding and maturation of HIV virion R-HSA-162588 4.135239e-01 0.383 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.376421e-01 0.359 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.279819e-01 0.484 0 0
Platelet activation, signaling and aggregation R-HSA-76002 2.389167e-01 0.622 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 2.919547e-01 0.535 0 0
G-protein beta:gamma signalling R-HSA-397795 4.523977e-01 0.344 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 4.523977e-01 0.344 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.725735e-01 0.429 0 0
Activation of SMO R-HSA-5635838 2.609515e-01 0.583 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.184724e-01 0.497 0 0
PLC beta mediated events R-HSA-112043 2.698691e-01 0.569 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 2.867386e-01 0.543 0 0
Receptor Mediated Mitophagy R-HSA-8934903 3.191071e-01 0.496 0 0
Signal attenuation R-HSA-74749 3.191071e-01 0.496 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 3.146577e-01 0.502 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 3.344327e-01 0.476 0 0
Generic Transcription Pathway R-HSA-212436 2.523445e-01 0.598 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 2.949894e-01 0.530 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 3.991988e-01 0.399 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 2.542098e-01 0.595 0 0
Regulated proteolysis of p75NTR R-HSA-193692 2.867386e-01 0.543 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.310446e-01 0.636 0 0
G1/S Transition R-HSA-69206 2.627405e-01 0.580 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 2.867386e-01 0.543 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.019864e-01 0.520 0 0
Host Interactions of HIV factors R-HSA-162909 2.459635e-01 0.609 0 0
HCMV Late Events R-HSA-9610379 3.818535e-01 0.418 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 4.271411e-01 0.369 0 0
Kinesins R-HSA-983189 2.575633e-01 0.589 0 0
TBC/RABGAPs R-HSA-8854214 2.986400e-01 0.525 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.498402e-01 0.456 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 3.463727e-01 0.460 0 0
G-protein mediated events R-HSA-112040 3.465521e-01 0.460 0 0
Deubiquitination R-HSA-5688426 2.514690e-01 0.600 0 0
Inhibition of membrane repair R-HSA-9635644 2.330371e-01 0.633 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.330371e-01 0.633 0 0
Cellular response to mitochondrial stress R-HSA-9840373 2.867386e-01 0.543 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.375054e-01 0.624 0 0
Effects of PIP2 hydrolysis R-HSA-114508 2.814932e-01 0.551 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.575633e-01 0.589 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 4.501382e-01 0.347 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 3.344327e-01 0.476 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 4.501382e-01 0.347 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.647988e-01 0.577 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 3.893090e-01 0.410 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 4.189197e-01 0.378 0 0
Muscle contraction R-HSA-397014 2.469941e-01 0.607 0 0
Protein hydroxylation R-HSA-9629569 3.802161e-01 0.420 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 2.867386e-01 0.543 0 0
Suppression of apoptosis R-HSA-9635465 3.511095e-01 0.455 0 0
Selenocysteine synthesis R-HSA-2408557 2.919547e-01 0.535 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 4.242758e-01 0.372 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 3.325068e-01 0.478 0 0
Signal transduction by L1 R-HSA-445144 3.802161e-01 0.420 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 4.124065e-01 0.385 0 0
The NLRP1 inflammasome R-HSA-844455 3.573932e-01 0.447 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.191071e-01 0.496 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 2.609515e-01 0.583 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.754862e-01 0.560 0 0
Neurodegenerative Diseases R-HSA-8863678 2.754862e-01 0.560 0 0
Maturation of nucleoprotein R-HSA-9683610 4.433748e-01 0.353 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 4.501382e-01 0.347 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 3.450194e-01 0.462 0 0
STING mediated induction of host immune responses R-HSA-1834941 3.564213e-01 0.448 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 3.344327e-01 0.476 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 2.979614e-01 0.526 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 2.867386e-01 0.543 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.375054e-01 0.624 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.375054e-01 0.624 0 0
tRNA processing R-HSA-72306 2.397072e-01 0.620 0 0
Diseases of programmed cell death R-HSA-9645723 3.569825e-01 0.447 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.533521e-01 0.452 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.138518e-01 0.503 0 0
Josephin domain DUBs R-HSA-5689877 3.191071e-01 0.496 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 2.983834e-01 0.525 0 0
CD28 dependent Vav1 pathway R-HSA-389359 4.433748e-01 0.353 0 0
Regulation of gene expression in beta cells R-HSA-210745 3.740815e-01 0.427 0 0
Signaling by ALK R-HSA-201556 3.844279e-01 0.415 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 4.523977e-01 0.344 0 0
Heme signaling R-HSA-9707616 4.242758e-01 0.372 0 0
Specification of primordial germ cells R-HSA-9827857 3.085591e-01 0.511 0 0
Signaling by Interleukins R-HSA-449147 3.184867e-01 0.497 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.511095e-01 0.455 0 0
Glucose metabolism R-HSA-70326 2.748692e-01 0.561 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.446064e-01 0.463 0 0
OAS antiviral response R-HSA-8983711 4.133683e-01 0.384 0 0
Pyroptosis R-HSA-5620971 3.542583e-01 0.451 0 0
FLT3 Signaling R-HSA-9607240 4.189197e-01 0.378 0 0
Interleukin-7 signaling R-HSA-1266695 2.949894e-01 0.530 0 0
Regulation of beta-cell development R-HSA-186712 3.816043e-01 0.418 0 0
Signaling by Leptin R-HSA-2586552 3.191071e-01 0.496 0 0
SARS-CoV-2 Infection R-HSA-9694516 2.984250e-01 0.525 0 0
SARS-CoV Infections R-HSA-9679506 2.998446e-01 0.523 0 0
RET signaling R-HSA-8853659 3.325950e-01 0.478 0 0
SARS-CoV-1 Infection R-HSA-9678108 4.510415e-01 0.346 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 3.844279e-01 0.415 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 2.372218e-01 0.625 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 3.325068e-01 0.478 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 4.589239e-01 0.338 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.603695e-01 0.337 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 4.615979e-01 0.336 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 4.615979e-01 0.336 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 4.615979e-01 0.336 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 4.615979e-01 0.336 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 4.615979e-01 0.336 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 4.615979e-01 0.336 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 4.615979e-01 0.336 0 0
Activation of AKT2 R-HSA-165158 4.615979e-01 0.336 0 0
Reelin signalling pathway R-HSA-8866376 4.615979e-01 0.336 0 0
Muscarinic acetylcholine receptors R-HSA-390648 4.615979e-01 0.336 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 4.615979e-01 0.336 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 4.615979e-01 0.336 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 4.615979e-01 0.336 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.615979e-01 0.336 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 4.633971e-01 0.334 0 0
Response of Mtb to phagocytosis R-HSA-9637690 4.699405e-01 0.328 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 4.715224e-01 0.326 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 4.715224e-01 0.326 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 4.725081e-01 0.326 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 4.725081e-01 0.326 0 0
Removal of the Flap Intermediate R-HSA-69166 4.725081e-01 0.326 0 0
Retrograde neurotrophin signalling R-HSA-177504 4.725081e-01 0.326 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 4.725081e-01 0.326 0 0
NRIF signals cell death from the nucleus R-HSA-205043 4.725081e-01 0.326 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 4.727488e-01 0.325 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 4.727488e-01 0.325 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 4.727488e-01 0.325 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 4.727488e-01 0.325 0 0
COPI-mediated anterograde transport R-HSA-6807878 4.734410e-01 0.325 0 0
Synthesis of DNA R-HSA-69239 4.823744e-01 0.317 0 0
G alpha (z) signalling events R-HSA-418597 4.834235e-01 0.316 0 0
Platelet degranulation R-HSA-114608 4.877674e-01 0.312 0 0
Dual Incision in GG-NER R-HSA-5696400 4.903927e-01 0.309 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 4.903927e-01 0.309 0 0
Gap junction assembly R-HSA-190861 4.903927e-01 0.309 0 0
Mitochondrial biogenesis R-HSA-1592230 4.904312e-01 0.309 0 0
PCP/CE pathway R-HSA-4086400 4.909267e-01 0.309 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 4.933089e-01 0.307 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.949245e-01 0.305 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 4.949245e-01 0.305 0 0
Deadenylation of mRNA R-HSA-429947 4.949245e-01 0.305 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 4.949245e-01 0.305 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 4.964459e-01 0.304 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 4.964459e-01 0.304 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 4.964459e-01 0.304 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.984364e-01 0.302 0 0
TNF signaling R-HSA-75893 4.984364e-01 0.302 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 4.995841e-01 0.301 0 0
Erythropoietin activates RAS R-HSA-9027284 5.007010e-01 0.300 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 5.007010e-01 0.300 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.007010e-01 0.300 0 0
p75NTR signals via NF-kB R-HSA-193639 5.007010e-01 0.300 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.007010e-01 0.300 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 5.007010e-01 0.300 0 0
Protein methylation R-HSA-8876725 5.007010e-01 0.300 0 0
Homology Directed Repair R-HSA-5693538 5.008500e-01 0.300 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 5.041881e-01 0.297 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 5.071851e-01 0.295 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.071851e-01 0.295 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 5.071851e-01 0.295 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 5.071851e-01 0.295 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.071851e-01 0.295 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.071851e-01 0.295 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.071851e-01 0.295 0 0
Signaling by RNF43 mutants R-HSA-5340588 5.071851e-01 0.295 0 0
Ligand-receptor interactions R-HSA-5632681 5.071851e-01 0.295 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.071851e-01 0.295 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.071851e-01 0.295 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.071851e-01 0.295 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 5.071851e-01 0.295 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 5.071851e-01 0.295 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 5.071851e-01 0.295 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 5.071851e-01 0.295 0 0
Regulated Necrosis R-HSA-5218859 5.081692e-01 0.294 0 0
Oncogene Induced Senescence R-HSA-2559585 5.089779e-01 0.293 0 0
Signalling to ERKs R-HSA-187687 5.089779e-01 0.293 0 0
PERK regulates gene expression R-HSA-381042 5.089779e-01 0.293 0 0
Base Excision Repair R-HSA-73884 5.119227e-01 0.291 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 5.132957e-01 0.290 0 0
MyD88-independent TLR4 cascade R-HSA-166166 5.150047e-01 0.288 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 5.150047e-01 0.288 0 0
Signaling by FGFR2 R-HSA-5654738 5.165110e-01 0.287 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 5.166236e-01 0.287 0 0
Acyl chain remodelling of PS R-HSA-1482801 5.166236e-01 0.287 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 5.176638e-01 0.286 0 0
Potential therapeutics for SARS R-HSA-9679191 5.200295e-01 0.284 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.272502e-01 0.278 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 5.279039e-01 0.277 0 0
Phosphorylation of the APC/C R-HSA-176412 5.279039e-01 0.277 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.279039e-01 0.277 0 0
Killing mechanisms R-HSA-9664420 5.279039e-01 0.277 0 0
Prolonged ERK activation events R-HSA-169893 5.279039e-01 0.277 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.279039e-01 0.277 0 0
Negative regulation of FLT3 R-HSA-9706369 5.279039e-01 0.277 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 5.279039e-01 0.277 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 5.279039e-01 0.277 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 5.352511e-01 0.271 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 5.355381e-01 0.271 0 0
Signaling by EGFR in Cancer R-HSA-1643713 5.378106e-01 0.269 0 0
Suppression of phagosomal maturation R-HSA-9637687 5.378106e-01 0.269 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 5.378106e-01 0.269 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 5.383066e-01 0.269 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 5.424902e-01 0.266 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 5.451851e-01 0.263 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 5.470108e-01 0.262 0 0
DNA Replication R-HSA-69306 5.473644e-01 0.262 0 0
Hedgehog 'on' state R-HSA-5632684 5.485670e-01 0.261 0 0
Signaling by LTK in cancer R-HSA-9842640 5.489148e-01 0.260 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.489148e-01 0.260 0 0
Autointegration results in viral DNA circles R-HSA-177539 5.489148e-01 0.260 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 5.489148e-01 0.260 0 0
MET Receptor Activation R-HSA-6806942 5.489148e-01 0.260 0 0
G2/M DNA replication checkpoint R-HSA-69478 5.489148e-01 0.260 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 5.489148e-01 0.260 0 0
Nef and signal transduction R-HSA-164944 5.489148e-01 0.260 0 0
MHC class II antigen presentation R-HSA-2132295 5.520307e-01 0.258 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 5.540823e-01 0.256 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 5.540823e-01 0.256 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 5.540823e-01 0.256 0 0
Coenzyme A biosynthesis R-HSA-196783 5.540823e-01 0.256 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 5.540823e-01 0.256 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.540823e-01 0.256 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 5.540823e-01 0.256 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 5.584558e-01 0.253 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 5.584558e-01 0.253 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 5.584558e-01 0.253 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 5.584558e-01 0.253 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.584558e-01 0.253 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 5.608244e-01 0.251 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 5.627607e-01 0.250 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 5.627607e-01 0.250 0 0
Response of endothelial cells to shear stress R-HSA-9860931 5.636081e-01 0.249 0 0
DNA Repair R-HSA-73894 5.658169e-01 0.247 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 5.662513e-01 0.247 0 0
DNA Damage Bypass R-HSA-73893 5.669142e-01 0.246 0 0
Switching of origins to a post-replicative state R-HSA-69052 5.746932e-01 0.241 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 5.758439e-01 0.240 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 5.783332e-01 0.238 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 5.785348e-01 0.238 0 0
Formation of the Early Elongation Complex R-HSA-113418 5.785348e-01 0.238 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 5.785348e-01 0.238 0 0
Inflammasomes R-HSA-622312 5.785348e-01 0.238 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 5.792147e-01 0.237 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 5.792147e-01 0.237 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 5.792147e-01 0.237 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 5.792147e-01 0.237 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 5.792147e-01 0.237 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 5.792147e-01 0.237 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 5.792147e-01 0.237 0 0
Uptake and function of anthrax toxins R-HSA-5210891 5.792147e-01 0.237 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 5.818028e-01 0.235 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 5.818028e-01 0.235 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 5.818028e-01 0.235 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 5.818248e-01 0.235 0 0
NCAM signaling for neurite out-growth R-HSA-375165 5.847621e-01 0.233 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 5.871133e-01 0.231 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 5.871133e-01 0.231 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 5.871133e-01 0.231 0 0
TRIF-mediated programmed cell death R-HSA-2562578 5.871133e-01 0.231 0 0
Recycling of eIF2:GDP R-HSA-72731 5.871133e-01 0.231 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 5.871133e-01 0.231 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 5.871133e-01 0.231 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 5.871133e-01 0.231 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 5.871133e-01 0.231 0 0
PTK6 Expression R-HSA-8849473 5.871133e-01 0.231 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 5.871133e-01 0.231 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 5.871133e-01 0.231 0 0
VLDL clearance R-HSA-8964046 5.871133e-01 0.231 0 0
Netrin mediated repulsion signals R-HSA-418886 5.871133e-01 0.231 0 0
Regulation of PTEN localization R-HSA-8948747 5.871133e-01 0.231 0 0
CHL1 interactions R-HSA-447041 5.871133e-01 0.231 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 5.871133e-01 0.231 0 0
Maturation of replicase proteins R-HSA-9694301 5.871133e-01 0.231 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 5.967610e-01 0.224 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 5.967610e-01 0.224 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 5.980283e-01 0.223 0 0
mRNA Capping R-HSA-72086 5.980283e-01 0.223 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.980283e-01 0.223 0 0
Neutrophil degranulation R-HSA-6798695 6.000683e-01 0.222 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 6.000799e-01 0.222 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.032905e-01 0.219 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 6.032905e-01 0.219 0 0
Polo-like kinase mediated events R-HSA-156711 6.032905e-01 0.219 0 0
Synaptic adhesion-like molecules R-HSA-8849932 6.032905e-01 0.219 0 0
Apoptotic factor-mediated response R-HSA-111471 6.032905e-01 0.219 0 0
Platelet sensitization by LDL R-HSA-432142 6.032905e-01 0.219 0 0
Mismatch Repair R-HSA-5358508 6.032905e-01 0.219 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 6.032905e-01 0.219 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.040975e-01 0.219 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 6.063743e-01 0.217 0 0
Orc1 removal from chromatin R-HSA-68949 6.118396e-01 0.213 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 6.118396e-01 0.213 0 0
Ribosome-associated quality control R-HSA-9948299 6.129407e-01 0.213 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 6.131555e-01 0.212 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 6.131555e-01 0.212 0 0
Telomere Maintenance R-HSA-157579 6.150111e-01 0.211 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 6.169214e-01 0.210 0 0
Interleukin-37 signaling R-HSA-9008059 6.169214e-01 0.210 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 6.169214e-01 0.210 0 0
Viral Infection Pathways R-HSA-9824446 6.169519e-01 0.210 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 6.195753e-01 0.208 0 0
RSK activation R-HSA-444257 6.220791e-01 0.206 0 0
phospho-PLA2 pathway R-HSA-111995 6.220791e-01 0.206 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.220791e-01 0.206 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 6.220791e-01 0.206 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 6.220791e-01 0.206 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 6.220791e-01 0.206 0 0
Adrenoceptors R-HSA-390696 6.220791e-01 0.206 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.220791e-01 0.206 0 0
FGFR1b ligand binding and activation R-HSA-190370 6.220791e-01 0.206 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.220791e-01 0.206 0 0
Alpha-defensins R-HSA-1462054 6.220791e-01 0.206 0 0
Sodium/Proton exchangers R-HSA-425986 6.220791e-01 0.206 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 6.220791e-01 0.206 0 0
Signaling by FGFR R-HSA-190236 6.257688e-01 0.204 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.263085e-01 0.203 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.263085e-01 0.203 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.263085e-01 0.203 0 0
The NLRP3 inflammasome R-HSA-844456 6.263085e-01 0.203 0 0
Maturation of nucleoprotein R-HSA-9694631 6.263085e-01 0.203 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 6.280530e-01 0.202 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 6.280530e-01 0.202 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.291302e-01 0.201 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 6.352036e-01 0.197 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 6.352036e-01 0.197 0 0
FOXO-mediated transcription R-HSA-9614085 6.363656e-01 0.196 0 0
Integrin cell surface interactions R-HSA-216083 6.366292e-01 0.196 0 0
rRNA processing R-HSA-72312 6.372183e-01 0.196 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 6.402286e-01 0.194 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 6.409795e-01 0.193 0 0
Cellular response to chemical stress R-HSA-9711123 6.427842e-01 0.192 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 6.446759e-01 0.191 0 0
Hedgehog 'off' state R-HSA-5610787 6.467968e-01 0.189 0 0
Nephrin family interactions R-HSA-373753 6.482750e-01 0.188 0 0
Signaling by NODAL R-HSA-1181150 6.482750e-01 0.188 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 6.482750e-01 0.188 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 6.483769e-01 0.188 0 0
DNA Double Strand Break Response R-HSA-5693606 6.504320e-01 0.187 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 6.528678e-01 0.185 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 6.540857e-01 0.184 0 0
Calcineurin activates NFAT R-HSA-2025928 6.540857e-01 0.184 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 6.540857e-01 0.184 0 0
p75NTR regulates axonogenesis R-HSA-193697 6.540857e-01 0.184 0 0
ARMS-mediated activation R-HSA-170984 6.540857e-01 0.184 0 0
Regulation of signaling by NODAL R-HSA-1433617 6.540857e-01 0.184 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 6.540857e-01 0.184 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 6.540857e-01 0.184 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 6.540857e-01 0.184 0 0
Interleukin-1 processing R-HSA-448706 6.540857e-01 0.184 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 6.540857e-01 0.184 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 6.564485e-01 0.183 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 6.564485e-01 0.183 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.581026e-01 0.182 0 0
Transcription of the HIV genome R-HSA-167172 6.627755e-01 0.179 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 6.656407e-01 0.177 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 6.672911e-01 0.176 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 6.672911e-01 0.176 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 6.692032e-01 0.174 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.692032e-01 0.174 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 6.692032e-01 0.174 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 6.699106e-01 0.174 0 0
Regulation of necroptotic cell death R-HSA-5675482 6.699106e-01 0.174 0 0
Processing of DNA double-strand break ends R-HSA-5693607 6.711870e-01 0.173 0 0
Cyclin D associated events in G1 R-HSA-69231 6.744542e-01 0.171 0 0
G1 Phase R-HSA-69236 6.744542e-01 0.171 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 6.756173e-01 0.170 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 6.833834e-01 0.165 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 6.833834e-01 0.165 0 0
Binding and entry of HIV virion R-HSA-173107 6.833834e-01 0.165 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 6.833834e-01 0.165 0 0
Formation of intermediate mesoderm R-HSA-9761174 6.833834e-01 0.165 0 0
Pexophagy R-HSA-9664873 6.833834e-01 0.165 0 0
Sperm Motility And Taxes R-HSA-1300642 6.833834e-01 0.165 0 0
Opioid Signalling R-HSA-111885 6.867882e-01 0.163 0 0
Serine metabolism R-HSA-977347 6.891112e-01 0.162 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 6.891112e-01 0.162 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 6.929848e-01 0.159 0 0
Activation of HOX genes during differentiation R-HSA-5619507 6.963367e-01 0.157 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 6.963367e-01 0.157 0 0
Interferon gamma signaling R-HSA-877300 6.975429e-01 0.156 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 7.021332e-01 0.154 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 7.021332e-01 0.154 0 0
Signaling by NOTCH2 R-HSA-1980145 7.021332e-01 0.154 0 0
Mitophagy R-HSA-5205647 7.021332e-01 0.154 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 7.021332e-01 0.154 0 0
Extension of Telomeres R-HSA-180786 7.053103e-01 0.152 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 7.053103e-01 0.152 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 7.076046e-01 0.150 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 7.080218e-01 0.150 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.080218e-01 0.150 0 0
Signaling by KIT in disease R-HSA-9669938 7.080218e-01 0.150 0 0
LDL clearance R-HSA-8964038 7.080218e-01 0.150 0 0
G2/M Checkpoints R-HSA-69481 7.094324e-01 0.149 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 7.102013e-01 0.149 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.102013e-01 0.149 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 7.102013e-01 0.149 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 7.102013e-01 0.149 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 7.102013e-01 0.149 0 0
vRNA Synthesis R-HSA-192814 7.102013e-01 0.149 0 0
Signaling by APC mutants R-HSA-4839744 7.102013e-01 0.149 0 0
vRNP Assembly R-HSA-192905 7.102013e-01 0.149 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.102013e-01 0.149 0 0
Gastrulation R-HSA-9758941 7.139675e-01 0.146 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 7.157880e-01 0.145 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 7.188559e-01 0.143 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.259609e-01 0.139 0 0
Carnitine shuttle R-HSA-200425 7.259609e-01 0.139 0 0
Growth hormone receptor signaling R-HSA-982772 7.259609e-01 0.139 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 7.259649e-01 0.139 0 0
G2/M DNA damage checkpoint R-HSA-69473 7.309130e-01 0.136 0 0
G1/S-Specific Transcription R-HSA-69205 7.318990e-01 0.136 0 0
Regulation of TP53 Degradation R-HSA-6804757 7.318990e-01 0.136 0 0
Selenoamino acid metabolism R-HSA-2408522 7.345100e-01 0.134 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 7.347491e-01 0.134 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 7.347491e-01 0.134 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 7.347491e-01 0.134 0 0
Signaling by GSK3beta mutants R-HSA-5339716 7.347491e-01 0.134 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 7.347491e-01 0.134 0 0
Plasmalogen biosynthesis R-HSA-75896 7.347491e-01 0.134 0 0
Signaling by AMER1 mutants R-HSA-4839748 7.347491e-01 0.134 0 0
ERKs are inactivated R-HSA-202670 7.347491e-01 0.134 0 0
Signaling by AXIN mutants R-HSA-4839735 7.347491e-01 0.134 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 7.347491e-01 0.134 0 0
Anchoring fibril formation R-HSA-2214320 7.347491e-01 0.134 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 7.401880e-01 0.131 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 7.401880e-01 0.131 0 0
Degradation of CDH1 R-HSA-9766229 7.411199e-01 0.130 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 7.412634e-01 0.130 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 7.429576e-01 0.129 0 0
Mitochondrial RNA degradation R-HSA-9836573 7.429576e-01 0.129 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 7.429576e-01 0.129 0 0
Complex III assembly R-HSA-9865881 7.429576e-01 0.129 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 7.458789e-01 0.127 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 7.511161e-01 0.124 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 7.511161e-01 0.124 0 0
PI3K Cascade R-HSA-109704 7.531264e-01 0.123 0 0
SLC transporter disorders R-HSA-5619102 7.552405e-01 0.122 0 0
MET activates RAS signaling R-HSA-8851805 7.572189e-01 0.121 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 7.572189e-01 0.121 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 7.572189e-01 0.121 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 7.572189e-01 0.121 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 7.572189e-01 0.121 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 7.572189e-01 0.121 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 7.572189e-01 0.121 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.572189e-01 0.121 0 0
Regulation of IFNG signaling R-HSA-877312 7.572189e-01 0.121 0 0
p75NTR recruits signalling complexes R-HSA-209543 7.572189e-01 0.121 0 0
Signaling by LTK R-HSA-9842663 7.572189e-01 0.121 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 7.572189e-01 0.121 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 7.572189e-01 0.121 0 0
Toll-like Receptor Cascades R-HSA-168898 7.576655e-01 0.121 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 7.590426e-01 0.120 0 0
Hyaluronan degradation R-HSA-2160916 7.590426e-01 0.120 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 7.590426e-01 0.120 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 7.592701e-01 0.120 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 7.592701e-01 0.120 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 7.616982e-01 0.118 0 0
Meiotic recombination R-HSA-912446 7.646995e-01 0.117 0 0
Plasma lipoprotein clearance R-HSA-8964043 7.720843e-01 0.112 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 7.720843e-01 0.112 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.742485e-01 0.111 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 7.758448e-01 0.110 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 7.777865e-01 0.109 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 7.777865e-01 0.109 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 7.777865e-01 0.109 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 7.777865e-01 0.109 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 7.777865e-01 0.109 0 0
FGFR1c ligand binding and activation R-HSA-190373 7.777865e-01 0.109 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 7.777865e-01 0.109 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 7.777865e-01 0.109 0 0
Interleukin-6 signaling R-HSA-1059683 7.777865e-01 0.109 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 7.777865e-01 0.109 0 0
PI Metabolism R-HSA-1483255 7.800696e-01 0.108 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 7.843345e-01 0.105 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.843345e-01 0.105 0 0
Diseases of Immune System R-HSA-5260271 7.843345e-01 0.105 0 0
Generation of second messenger molecules R-HSA-202433 7.843345e-01 0.105 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 7.843345e-01 0.105 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.865692e-01 0.104 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.886086e-01 0.103 0 0
Maturation of hRSV A proteins R-HSA-9828806 7.886086e-01 0.103 0 0
Insulin processing R-HSA-264876 7.886086e-01 0.103 0 0
Hemostasis R-HSA-109582 7.901868e-01 0.102 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 7.914010e-01 0.102 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 7.923057e-01 0.101 0 0
CRMPs in Sema3A signaling R-HSA-399956 7.966127e-01 0.099 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 7.966127e-01 0.099 0 0
Hydrolysis of LPC R-HSA-1483115 7.966127e-01 0.099 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 7.966127e-01 0.099 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 7.966127e-01 0.099 0 0
Physiological factors R-HSA-5578768 7.966127e-01 0.099 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 7.966127e-01 0.099 0 0
Acyl chain remodeling of CL R-HSA-1482798 7.966127e-01 0.099 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 7.966127e-01 0.099 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 8.006343e-01 0.097 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 8.021572e-01 0.096 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.021572e-01 0.096 0 0
Signaling by Hedgehog R-HSA-5358351 8.053488e-01 0.094 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.071994e-01 0.093 0 0
HIV Transcription Initiation R-HSA-167161 8.071994e-01 0.093 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.071994e-01 0.093 0 0
Co-inhibition by PD-1 R-HSA-389948 8.099116e-01 0.092 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.114437e-01 0.091 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.138450e-01 0.089 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 8.138450e-01 0.089 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 8.138450e-01 0.089 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.138450e-01 0.089 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.138450e-01 0.089 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.138450e-01 0.089 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.138450e-01 0.089 0 0
Signaling by Activin R-HSA-1502540 8.138450e-01 0.089 0 0
p38MAPK events R-HSA-171007 8.138450e-01 0.089 0 0
Signaling by Erythropoietin R-HSA-9006335 8.149286e-01 0.089 0 0
DARPP-32 events R-HSA-180024 8.149286e-01 0.089 0 0
Platelet calcium homeostasis R-HSA-418360 8.149286e-01 0.089 0 0
Signaling by FGFR1 R-HSA-5654736 8.162932e-01 0.088 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.178442e-01 0.087 0 0
Depyrimidination R-HSA-73928 8.178442e-01 0.087 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.237664e-01 0.084 0 0
IRS-mediated signalling R-HSA-112399 8.254134e-01 0.083 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.269573e-01 0.083 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.279850e-01 0.082 0 0
Signaling by FGFR4 R-HSA-5654743 8.279850e-01 0.082 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 8.296182e-01 0.081 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.296182e-01 0.081 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 8.296182e-01 0.081 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.296182e-01 0.081 0 0
Differentiation of T cells R-HSA-9945266 8.296182e-01 0.081 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.296182e-01 0.081 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.296182e-01 0.081 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.296182e-01 0.081 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.341551e-01 0.079 0 0
Dual incision in TC-NER R-HSA-6782135 8.341551e-01 0.079 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 8.343690e-01 0.079 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.382773e-01 0.077 0 0
Downstream signal transduction R-HSA-186763 8.382773e-01 0.077 0 0
Ca2+ pathway R-HSA-4086398 8.420335e-01 0.075 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 8.440558e-01 0.074 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 8.440558e-01 0.074 0 0
Passive transport by Aquaporins R-HSA-432047 8.440558e-01 0.074 0 0
Fibronectin matrix formation R-HSA-1566977 8.440558e-01 0.074 0 0
Synthesis of PG R-HSA-1483148 8.440558e-01 0.074 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 8.440558e-01 0.074 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.440558e-01 0.074 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.468194e-01 0.072 0 0
Signaling by FGFR3 R-HSA-5654741 8.468194e-01 0.072 0 0
Signaling by WNT in cancer R-HSA-4791275 8.489223e-01 0.071 0 0
Signaling by ERBB4 R-HSA-1236394 8.494034e-01 0.071 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.555462e-01 0.068 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 8.572708e-01 0.067 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.572708e-01 0.067 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.572708e-01 0.067 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.572708e-01 0.067 0 0
Glycogen storage diseases R-HSA-3229121 8.572708e-01 0.067 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 8.572708e-01 0.067 0 0
Choline catabolism R-HSA-6798163 8.572708e-01 0.067 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.572708e-01 0.067 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.582090e-01 0.066 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.582090e-01 0.066 0 0
FGFR1 mutant receptor activation R-HSA-1839124 8.589255e-01 0.066 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 8.612502e-01 0.065 0 0
ER to Golgi Anterograde Transport R-HSA-199977 8.615762e-01 0.065 0 0
Signaling by PDGF R-HSA-186797 8.655372e-01 0.063 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.683191e-01 0.061 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.683191e-01 0.061 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.683191e-01 0.061 0 0
PKA activation R-HSA-163615 8.693666e-01 0.061 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 8.693666e-01 0.061 0 0
PKA activation in glucagon signalling R-HSA-164378 8.693666e-01 0.061 0 0
FGFR1 ligand binding and activation R-HSA-190242 8.693666e-01 0.061 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 8.693666e-01 0.061 0 0
Intraflagellar transport R-HSA-5620924 8.717023e-01 0.060 0 0
eNOS activation R-HSA-203615 8.771346e-01 0.057 0 0
Hyaluronan metabolism R-HSA-2142845 8.771346e-01 0.057 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.771346e-01 0.057 0 0
Signal amplification R-HSA-392518 8.771346e-01 0.057 0 0
IGF1R signaling cascade R-HSA-2428924 8.792221e-01 0.056 0 0
Insulin receptor signalling cascade R-HSA-74751 8.792221e-01 0.056 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 8.804380e-01 0.055 0 0
Crosslinking of collagen fibrils R-HSA-2243919 8.804380e-01 0.055 0 0
Pyrimidine biosynthesis R-HSA-500753 8.804380e-01 0.055 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 8.804380e-01 0.055 0 0
Diseases of hemostasis R-HSA-9671793 8.804380e-01 0.055 0 0
Rap1 signalling R-HSA-392517 8.804380e-01 0.055 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.804380e-01 0.055 0 0
Sensory processing of sound R-HSA-9659379 8.820863e-01 0.054 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.854024e-01 0.053 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 8.854024e-01 0.053 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.855998e-01 0.053 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.861531e-01 0.052 0 0
Parasite infection R-HSA-9664407 8.861531e-01 0.052 0 0
Leishmania phagocytosis R-HSA-9664417 8.861531e-01 0.052 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 8.878413e-01 0.052 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 8.905717e-01 0.050 0 0
Glycogen synthesis R-HSA-3322077 8.905717e-01 0.050 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 8.905717e-01 0.050 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 8.905717e-01 0.050 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 8.905717e-01 0.050 0 0
Acyl chain remodelling of PI R-HSA-1482922 8.905717e-01 0.050 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 8.905717e-01 0.050 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 8.916818e-01 0.050 0 0
The phototransduction cascade R-HSA-2514856 8.929403e-01 0.049 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.931521e-01 0.049 0 0
RNA Polymerase III Transcription R-HSA-74158 8.931521e-01 0.049 0 0
FLT3 signaling in disease R-HSA-9682385 8.931521e-01 0.049 0 0
Triglyceride catabolism R-HSA-163560 8.931521e-01 0.049 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.931521e-01 0.049 0 0
Amyloid fiber formation R-HSA-977225 8.933532e-01 0.049 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 8.992854e-01 0.046 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 8.992854e-01 0.046 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.992854e-01 0.046 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.998471e-01 0.046 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 8.998471e-01 0.046 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 8.998471e-01 0.046 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 8.998471e-01 0.046 0 0
Signalling to RAS R-HSA-167044 8.998471e-01 0.046 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 8.998471e-01 0.046 0 0
Acyl chain remodelling of PG R-HSA-1482925 8.998471e-01 0.046 0 0
Degradation of DVL R-HSA-4641258 9.004120e-01 0.046 0 0
NCAM1 interactions R-HSA-419037 9.004120e-01 0.046 0 0
Collagen chain trimerization R-HSA-8948216 9.004120e-01 0.046 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 9.052895e-01 0.043 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.052895e-01 0.043 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 9.072094e-01 0.042 0 0
Elastic fibre formation R-HSA-1566948 9.072094e-01 0.042 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.083367e-01 0.042 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.083367e-01 0.042 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.083367e-01 0.042 0 0
Assembly Of The HIV Virion R-HSA-175474 9.083367e-01 0.042 0 0
Glutathione synthesis and recycling R-HSA-174403 9.083367e-01 0.042 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.109678e-01 0.040 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 9.132596e-01 0.039 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.161072e-01 0.038 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.161072e-01 0.038 0 0
Ethanol oxidation R-HSA-71384 9.161072e-01 0.038 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.161072e-01 0.038 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.163352e-01 0.038 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 9.180174e-01 0.037 0 0
Regulation of mitotic cell cycle R-HSA-453276 9.180174e-01 0.037 0 0
ECM proteoglycans R-HSA-3000178 9.180174e-01 0.037 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.195208e-01 0.036 0 0
Glycogen metabolism R-HSA-8982491 9.195208e-01 0.036 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 9.214059e-01 0.036 0 0
Ion homeostasis R-HSA-5578775 9.214059e-01 0.036 0 0
Integration of energy metabolism R-HSA-163685 9.230941e-01 0.035 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.232194e-01 0.035 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.232194e-01 0.035 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.232194e-01 0.035 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.232194e-01 0.035 0 0
Formation of the ureteric bud R-HSA-9830674 9.232194e-01 0.035 0 0
Maturation of spike protein R-HSA-9694548 9.250837e-01 0.034 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.297290e-01 0.032 0 0
Interleukin-6 family signaling R-HSA-6783589 9.297290e-01 0.032 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.302823e-01 0.031 0 0
Signaling by FGFR1 in disease R-HSA-5655302 9.302823e-01 0.031 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.302823e-01 0.031 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.302823e-01 0.031 0 0
Heme biosynthesis R-HSA-189451 9.302823e-01 0.031 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.302823e-01 0.031 0 0
Translation of Structural Proteins R-HSA-9683701 9.302823e-01 0.031 0 0
Signaling by FGFR in disease R-HSA-1226099 9.309190e-01 0.031 0 0
Triglyceride metabolism R-HSA-8979227 9.349764e-01 0.029 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.356871e-01 0.029 0 0
Fertilization R-HSA-1187000 9.356871e-01 0.029 0 0
Laminin interactions R-HSA-3000157 9.356871e-01 0.029 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.356871e-01 0.029 0 0
Neuronal System R-HSA-112316 9.382075e-01 0.028 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.389963e-01 0.027 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 9.411403e-01 0.026 0 0
Metalloprotease DUBs R-HSA-5689901 9.411403e-01 0.026 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.411403e-01 0.026 0 0
TRP channels R-HSA-3295583 9.411403e-01 0.026 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.411403e-01 0.026 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.419563e-01 0.026 0 0
Translation of Structural Proteins R-HSA-9694635 9.419563e-01 0.026 0 0
RSV-host interactions R-HSA-9833110 9.426945e-01 0.026 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.427851e-01 0.026 0 0
Amine ligand-binding receptors R-HSA-375280 9.439045e-01 0.025 0 0
Packaging Of Telomere Ends R-HSA-171306 9.461314e-01 0.024 0 0
Cristae formation R-HSA-8949613 9.461314e-01 0.024 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 9.461314e-01 0.024 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.461314e-01 0.024 0 0
Triglyceride biosynthesis R-HSA-75109 9.461314e-01 0.024 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 9.461314e-01 0.024 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.462356e-01 0.024 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.463546e-01 0.024 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.478530e-01 0.023 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.478530e-01 0.023 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.478530e-01 0.023 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.478530e-01 0.023 0 0
Telomere Extension By Telomerase R-HSA-171319 9.506996e-01 0.022 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.506996e-01 0.022 0 0
Ub-specific processing proteases R-HSA-5689880 9.513488e-01 0.022 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.515354e-01 0.022 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.515354e-01 0.022 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.515354e-01 0.022 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.515354e-01 0.022 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.515354e-01 0.022 0 0
Collagen formation R-HSA-1474290 9.518306e-01 0.021 0 0
Transmission across Chemical Synapses R-HSA-112315 9.533249e-01 0.021 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 9.548806e-01 0.020 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.549687e-01 0.020 0 0
Cellular response to hypoxia R-HSA-1234174 9.558575e-01 0.020 0 0
TCR signaling R-HSA-202403 9.580086e-01 0.019 0 0
GPER1 signaling R-HSA-9634597 9.581685e-01 0.019 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.587073e-01 0.018 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.587073e-01 0.018 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.593473e-01 0.018 0 0
Formation of the cornified envelope R-HSA-6809371 9.597161e-01 0.018 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.611497e-01 0.017 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.622097e-01 0.017 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.622097e-01 0.017 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.635751e-01 0.016 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.639263e-01 0.016 0 0
Extracellular matrix organization R-HSA-1474244 9.641091e-01 0.016 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.654151e-01 0.015 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.665117e-01 0.015 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.665117e-01 0.015 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 9.682752e-01 0.014 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 9.683489e-01 0.014 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 9.683489e-01 0.014 0 0
Cardiogenesis R-HSA-9733709 9.683489e-01 0.014 0 0
PPARA activates gene expression R-HSA-1989781 9.686299e-01 0.014 0 0
Pyruvate metabolism R-HSA-70268 9.700111e-01 0.013 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.710339e-01 0.013 0 0
Resolution of D-Loop Structures R-HSA-5693537 9.710339e-01 0.013 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.714618e-01 0.013 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.732410e-01 0.012 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.734913e-01 0.012 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 9.734913e-01 0.012 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.734913e-01 0.012 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.734913e-01 0.012 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 9.734913e-01 0.012 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.734913e-01 0.012 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.734913e-01 0.012 0 0
Regulation of Apoptosis R-HSA-169911 9.757404e-01 0.011 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.757404e-01 0.011 0 0
Iron uptake and transport R-HSA-917937 9.773388e-01 0.010 0 0
GPVI-mediated activation cascade R-HSA-114604 9.777988e-01 0.010 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.777988e-01 0.010 0 0
Synthesis of PA R-HSA-1483166 9.786550e-01 0.009 0 0
Signaling by Insulin receptor R-HSA-74752 9.793520e-01 0.009 0 0
Voltage gated Potassium channels R-HSA-1296072 9.796826e-01 0.009 0 0
Cleavage of the damaged purine R-HSA-110331 9.796826e-01 0.009 0 0
Lysine catabolism R-HSA-71064 9.796826e-01 0.009 0 0
Depurination R-HSA-73927 9.814067e-01 0.008 0 0
Peroxisomal protein import R-HSA-9033241 9.816575e-01 0.008 0 0
Pentose phosphate pathway R-HSA-71336 9.829846e-01 0.007 0 0
RAS processing R-HSA-9648002 9.829846e-01 0.007 0 0
Aquaporin-mediated transport R-HSA-445717 9.842482e-01 0.007 0 0
Collagen degradation R-HSA-1442490 9.842482e-01 0.007 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.844286e-01 0.007 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.844286e-01 0.007 0 0
Interleukin-2 family signaling R-HSA-451927 9.844286e-01 0.007 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.848175e-01 0.007 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 9.864818e-01 0.006 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.866805e-01 0.006 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.869597e-01 0.006 0 0
Intra-Golgi traffic R-HSA-6811438 9.869597e-01 0.006 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.873306e-01 0.006 0 0
Ion transport by P-type ATPases R-HSA-936837 9.874797e-01 0.005 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.875757e-01 0.005 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.880666e-01 0.005 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.880666e-01 0.005 0 0
Interferon alpha/beta signaling R-HSA-909733 9.887817e-01 0.005 0 0
Defensins R-HSA-1461973 9.890796e-01 0.005 0 0
Interleukin-1 signaling R-HSA-9020702 9.891081e-01 0.005 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.893908e-01 0.005 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.901085e-01 0.004 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.901094e-01 0.004 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.903484e-01 0.004 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.908006e-01 0.004 0 0
Somitogenesis R-HSA-9824272 9.908551e-01 0.004 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.908551e-01 0.004 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.908551e-01 0.004 0 0
Diseases of DNA repair R-HSA-9675135 9.916315e-01 0.004 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.922475e-01 0.003 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.923421e-01 0.003 0 0
Synthesis of PC R-HSA-1483191 9.923421e-01 0.003 0 0
Neurotransmitter release cycle R-HSA-112310 9.925420e-01 0.003 0 0
Platelet homeostasis R-HSA-418346 9.926490e-01 0.003 0 0
Metabolism of cofactors R-HSA-8978934 9.927098e-01 0.003 0 0
Metabolism of porphyrins R-HSA-189445 9.927098e-01 0.003 0 0
Interleukin-1 family signaling R-HSA-446652 9.927519e-01 0.003 0 0
Gluconeogenesis R-HSA-70263 9.929923e-01 0.003 0 0
Metal ion SLC transporters R-HSA-425410 9.929923e-01 0.003 0 0
Stimuli-sensing channels R-HSA-2672351 9.935613e-01 0.003 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.935874e-01 0.003 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.939756e-01 0.003 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.940757e-01 0.003 0 0
Regulation of RAS by GAPs R-HSA-5658442 9.941320e-01 0.003 0 0
Azathioprine ADME R-HSA-9748787 9.941320e-01 0.003 0 0
Complex IV assembly R-HSA-9864848 9.946304e-01 0.002 0 0
Parasitic Infection Pathways R-HSA-9824443 9.947417e-01 0.002 0 0
Leishmania infection R-HSA-9658195 9.947417e-01 0.002 0 0
Immune System R-HSA-168256 9.953267e-01 0.002 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.955038e-01 0.002 0 0
Nucleotide biosynthesis R-HSA-8956320 9.955038e-01 0.002 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.957818e-01 0.002 0 0
Cholesterol biosynthesis R-HSA-191273 9.957818e-01 0.002 0 0
Interleukin-10 signaling R-HSA-6783783 9.957818e-01 0.002 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.957922e-01 0.002 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.961007e-01 0.002 0 0
Paracetamol ADME R-HSA-9753281 9.962352e-01 0.002 0 0
Regulation of insulin secretion R-HSA-422356 9.963586e-01 0.002 0 0
Digestion R-HSA-8935690 9.965550e-01 0.001 0 0
Infectious disease R-HSA-5663205 9.968493e-01 0.001 0 0
Phospholipid metabolism R-HSA-1483257 9.972597e-01 0.001 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.973606e-01 0.001 0 0
Translation R-HSA-72766 9.974828e-01 0.001 0 0
Protein localization R-HSA-9609507 9.975286e-01 0.001 0 0
tRNA Aminoacylation R-HSA-379724 9.975849e-01 0.001 0 0
Glutathione conjugation R-HSA-156590 9.975849e-01 0.001 0 0
Mitochondrial protein import R-HSA-1268020 9.979780e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.981498e-01 0.001 0 0
Digestion and absorption R-HSA-8963743 9.981498e-01 0.001 0 0
Downstream TCR signaling R-HSA-202424 9.984941e-01 0.001 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.984941e-01 0.001 0 0
Nicotinate metabolism R-HSA-196807 9.987031e-01 0.001 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.987031e-01 0.001 0 0
Kidney development R-HSA-9830369 9.987031e-01 0.001 0 0
FCGR activation R-HSA-2029481 9.989066e-01 0.000 0 0
Cardiac conduction R-HSA-5576891 9.989865e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.990066e-01 0.000 0 0
COPII-mediated vesicle transport R-HSA-204005 9.990066e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.992391e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.992391e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.993038e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.993630e-01 0.000 0 0
Adaptive Immune System R-HSA-1280218 9.993728e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.993775e-01 0.000 0 0
ABC-family proteins mediated transport R-HSA-382556 9.994258e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.994800e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.994980e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.995536e-01 0.000 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.996531e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.996628e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.996709e-01 0.000 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.996897e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.996897e-01 0.000 0 0
Keratinization R-HSA-6805567 9.997599e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.997649e-01 0.000 0 0
Ion channel transport R-HSA-983712 9.997734e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.997742e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.997833e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.997969e-01 0.000 0 0
ER-Phagosome pathway R-HSA-1236974 9.998322e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.998674e-01 0.000 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.998740e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.998874e-01 0.000 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.998925e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.999016e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.999247e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999469e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999548e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999662e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999667e-01 0.000 0 0
Disease R-HSA-1643685 9.999677e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999684e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999735e-01 0.000 0 0
Neddylation R-HSA-8951664 9.999762e-01 0.000 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.999763e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999855e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999914e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999935e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999936e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999937e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999937e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999937e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999955e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999956e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999971e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999972e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999987e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999993e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999995e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999995e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999995e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999997e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999999e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999999e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways