CK1G2

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
A6NMY6 S127 Sugiyama ANXA2P2 ANX2L2 ANX2P2 LPC2B AQyDAsELKAsMKGLGtDEDsLIEIICsRtNQELQEINRVy
A6NMY6 T123 Sugiyama ANXA2P2 ANX2L2 ANX2P2 LPC2B LKtPAQyDAsELKAsMKGLGtDEDsLIEIICsRtNQELQEI
O00165 S189 Sugiyama HAX1 HS1BP1 FDDVWPMDPHPRtREDNDLDsQVsQEGLGPVLQPQPKSYFK
O00165 S192 Sugiyama HAX1 HS1BP1 VWPMDPHPRtREDNDLDsQVsQEGLGPVLQPQPKSYFKsIS
O00566 S171 Sugiyama MPHOSPH10 MPP10 RAENSSKsDLRKsPVFsDEDsDLDFDISKLEQQSKVQNKGQ
O00571 S70 Sugiyama DDX3X DBX DDX3 KGFyDKDSSGWsssKDKDAyssFGsRsDsRGKssFFsDRGs
O14602 S102 Sugiyama EIF1AY RDYQDNKADVILKYNADEARsLKAyGELPEHAKINETDTFG
O14654 S859 SIGNOR|PSP IRS4 RGLDKEVSyNWDPKDAASKPsGEGsFSKPGDGGsPsKPSDH
O14980 S450 Sugiyama XPO1 CRM1 VLVVENDQGEVVREFMKDTDsINLyKNMRETLVyLTHLDyV
O15226 S532 Sugiyama NKRF ITBA4 NRF KKTQPTVINNLKKGAVEDVIsRNEIQGRSAEEAYKQQIKED
O15230 S1611 Sugiyama LAMA5 KIAA0533 KIAA1907 PLTGQCYCKENVQGPKCDQCsLGTFsLDAANPKGCTRCFCF
O15230 S1616 Sugiyama LAMA5 KIAA0533 KIAA1907 CYCKENVQGPKCDQCsLGTFsLDAANPKGCTRCFCFGATER
O15523 S70 Sugiyama DDX3Y DBY KGFHDKDSSGWSCSKDKDAyssFGsRDSRGKPGYFSERGSG
O43707 T445 Sugiyama ACTN4 HEAWtDGKEAMLKHRDyEtAtLsDIKALIRKHEAFEsDLAA
O43815 S229 Sugiyama STRN TEAEVKETAMIAKSELtDsAsVLDNFKFLEsAAADFsDEDE
O43823 S124 Sugiyama AKAP8 AKAP95 SKEGGRGGsGGGGEGIQDREssFRFQPFESYDSRPCLPEHN
O43847 S96 Sugiyama NRDC NRD1 SRVARLGADEsEEEGRRGsLsNAGDPEIVKsPsDPKQYRYI
O43852 S261 Sugiyama CALU RDKNRDGKMDKEEtKDWILPsDyDHAEAEARHLVyEsDQNK
O43852 S300 Sugiyama CALU NKDGKLTKEEIVDKyDLFVGsQAtDFGEALVRHDEF_____
O43852 S44 Sugiyama CALU KKDRVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQL
O43852 T303 Sugiyama CALU GKLTKEEIVDKyDLFVGsQAtDFGEALVRHDEF________
O60264 S825 Sugiyama SMARCA5 SNF2H WCRF135 ELPNAAQAQKEEQLKIDEAEsLNDEELEEKEKLLTQGFTNW
O60664 S225 Sugiyama PLIN3 M6PRBP1 TIP47 PLTDAELARIAtsLDGFDVAsVQQQRQEQSyFVRLGsLSER
O60701 S392 Sugiyama UGDH PREQIVVDLsHPGVSEDDQVsRLVTISKDPYEACDGAHAVV
O60763 S952 Sugiyama USO1 VDP HPVEEEDELEsGDQEDEDDEsEDPGKDLDHI__________
O75400 S935 Sugiyama PRPF40A FBP11 FLAF1 FNBP3 HIP10 HYPA HSPC225 KHKSPKKKtGKDsGNWDtsGsELsEGELEKRRRtLLEQLDD
O75400 S938 Sugiyama PRPF40A FBP11 FLAF1 FNBP3 HIP10 HYPA HSPC225 SPKKKtGKDsGNWDtsGsELsEGELEKRRRtLLEQLDDDQ_
O75821 T240 Sugiyama EIF3G EIF3S4 DGAsRRGESMQPNRRADDNAtIRVtNLSEDTRETDLQELFR
O95218 S181 Sugiyama ZRANB2 ZIS ZNF265 DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
O95714 S2928 Sugiyama HERC2 ILLGRIRAEEEDLAAVPFLAsDNEEEEDEKGNSGsLIRKKA
P00558 S390 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 IIGGGDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPG
P00558 S393 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 GGDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDA
P02545 S282 Sugiyama LMNA LMN1 ELEKTYSAKLDNARQsAERNsNLVGAAHEELQQsRIRIDsL
P04040 T441 Sugiyama CAT HSIQYSGEVRRFNtANDDNVtQVRAFyVNVLNEEQRKRLCE
P04075 S336 Sugiyama ALDOA ALDA GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04083 S189 Sugiyama ANXA1 ANX1 LPC1 tsDtsGDFRNALLsLAKGDRsEDFGVNEDLADsDARALyEA
P05023 S217 Sugiyama ATP1A1 DRIPADLRIIsANGCKVDNssLtGESEPQtRsPDFtNENPL
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05455 S225 Sugiyama SSB LRAKQEQEAKQKLEEDAEMKsLEEKIGCLLKFSGDLDDQTC
P05455 S325 Sugiyama SSB VLEGEVEKEALKKIIEDQQEsLNKWKSKGRRFKGKGKGNKA
P05787 S258 Sugiyama KRT8 CYK8 QISDTSVVLsMDNSRsLDMDsIIAEVKAQyEDIANRsRAEA
P05787 S280 Sugiyama KRT8 CYK8 IAEVKAQyEDIANRsRAEAEsMyQIKyEELQsLAGKHGDDL
P05787 S291 Sugiyama KRT8 CYK8 ANRsRAEAEsMyQIKyEELQsLAGKHGDDLRRTKTEISEMN
P07205 S390 Sugiyama PGK2 PGKB VIGGGDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPG
P07205 S393 Sugiyama PGK2 PGKB GGDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEA
P07355 S127 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D AQyDAsELKAsMKGLGtDEDsLIEIICsRtNQELQEINRVy
P07355 S184 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK
P07355 T123 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D LKtPAQyDAsELKAsMKGLGtDEDsLIEIICsRtNQELQEI
P07737 S30 Sugiyama PFN1 NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07814 S739 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 TKVEATKNETSAPFKERPtPsLNNNCttsEDsLVLyNRVAV
P07900 S476 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA RKKLsELLRyytsAsGDEMVsLKDYCTRMKENQKHIyyItG
P07900 S543 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA EPIDEyCVQQLKEFEGKtLVsVTKEGLELPEDEEEKKKQEE
P07900 T305 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IDQEELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLA
P07900 T540 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA yMIEPIDEyCVQQLKEFEGKtLVsVTKEGLELPEDEEEKKK
P07942 S449 Sugiyama LAMB1 KLNVEGEHCDVCKEGFyDLssEDPFGCKSCACNPLGTIPGG
P07948 S13 SIGNOR|PSP LYN JTK8 ________MGCIKSKGKDsLsDDGVDLKTQPVRNTERTIyV
P08238 S468 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238 T297 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IDQEELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLA
P08670 S214 Sugiyama VIM LQREEAENtLQsFRQDVDNAsLARLDLERKVEsLQEEIAFL
P09382 T58 Sugiyama LGALS1 DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P0CAP2 S187 Sugiyama POLR2M GRINL1A EASEHHPRHRVssQAEDtSssFDNLFIDRLQRITIADQGEQ
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P11047 S942 Sugiyama LAMC1 LAMB2 GFYNLQSGQGCERCDCHALGstNGQCDIRTGQCECQPGITG
P11142 S221 Sugiyama HSPA8 HSC70 HSP73 HSPA10 GGGTFDVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHF
P11142 T163 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11586 S129 Sugiyama MTHFD1 MTHFC MTHFD INTEEVINAIAPEKDVDGLtsINAGKLARGDLNDCFIPCtP
P13489 S290 Sugiyama RNH1 PRI RNH AKGCGDLCRVLRAKESLKELsLAGNELGDEGARLLCETLLE
P13637 S207 Sugiyama ATP1A3 DRVPADLRIISAHGCKVDNssLtGESEPQTRSPDCTHDNPL
P13639 S38 Sugiyama EEF2 EF2 NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13667 S126 Sugiyama PDIA4 ERP70 ERP72 NILKDKDPPIPVAKIDAtsAsVLAsRFDVsGyPtIKILKKG
P13861 S80 Sugiyama PRKAR2A PKR2 PRKAR2 GHPPPEPGPDRVADAKGDsEsEEDEDLEVPVPsRFNRRVsV
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14625 S523 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 RtRLAKLLRFQssHHPtDItsLDQyVERMKEKQDKIyFMAG
P18084 S507 Sugiyama ITGB5 CECSPGYLGTRCECQDGENQsVyQNLCREAEGKPLCSGRGD
P19338 S458 Sugiyama NCL TEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKN
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19338 Y462 Sugiyama NCL AEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNSTWs
P19838 S923 Sugiyama NFKB1 sLPLsPAstRQQIDELRDSDsVCDsGVEtsFRKLsFtEsLt
P20648 S228 Sugiyama ATP4A DRVPADIRILAAQGCKVDNssLtGESEPQTRSPECTHESPL
P20810 S311 Sugiyama CAST LEALsAsLGTRQAEPELDLRsIKEVDEAKAKEEKLEKCGED
P20810 S373 Sugiyama CAST LPEPEEKPKPRsEsELIDELsEDFDRsECKEKPSKPTEKTE
P22059 S190 Sugiyama OSBP OSBP1 QRWVTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNT
P22059 S193 Sugiyama OSBP OSBP1 VTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNTLRT
P25205 S704 Sugiyama MCM3 DQEQKRKRRKTRQPDAKDGDsyDPyDFsDtEEEMPQVHtPK
P25705 S53 Sugiyama ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM ARNFHASNTHLQKtGtAEMssILEERILGADtsVDLEETGR
P25788 S243 Sugiyama PSMA3 HC8 PSC8 GRHEIVPKDIREEAEKyAKEsLKEEDEsDDDNM________
P25788 Y239 Sugiyama PSMA3 HC8 PSC8 ELTNGRHEIVPKDIREEAEKyAKEsLKEEDEsDDDNM____
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P26641 S304 Sugiyama EEF1G EF1G PRO1608 PKstFVLDEFKRKysNEDtLsVALPyFWEHFDKDGWSLWyS
P26641 T302 Sugiyama EEF1G EF1G PRO1608 HLPKstFVLDEFKRKysNEDtLsVALPyFWEHFDKDGWSLW
P27797 S195 Sugiyama CALR CRTC IVRPDNtyEVKIDNsQVEsGsLEDDWDFLPPKKIKDPDAsK
P29401 S295 Sugiyama TKT ysQIQsKKKILAtPPQEDAPsVDIANIRMPsLPsyKVGDKI
P30041 S186 Sugiyama PRDX6 AOP2 KIAA0106 SLQLTAEKRVAtPVDWKDGDsVMVLPtIPEEEAKKLFPKGV
P30043 T199 Sugiyama BLVRB FLR SCAN HDLGHFMLRCLttDEyDGHstyPsHQyQ_____________
P31150 S316 Sugiyama GDI1 GDIL OPHN2 RABGDIA XAP4 QVIRIICILSHPIKNtNDANsCQIIIPQNQVNRKSDIYVCM
P31327 S1021 Sugiyama CPS1 RTLRQLGKKTVVVNCNPETVstDFDECDKLyFEELSLERIL
P31327 S1090 Sugiyama CPS1 KNGVKIMGTsPLQIDRAEDRsIFsAVLDELKVAQAPWKAVN
P31327 S1093 Sugiyama CPS1 VKIMGTsPLQIDRAEDRsIFsAVLDELKVAQAPWKAVNTLN
P31327 S564 Sugiyama CPS1 TEDRQLFSDKLNEINEKIAPsFAVEsIEDALKAADTIGyPV
P31327 S569 Sugiyama CPS1 LFSDKLNEINEKIAPsFAVEsIEDALKAADTIGyPVMIRSA
P31327 S863 Sugiyama CPS1 LSEPSsTRIyAIAKAIDDNMsLDEIEKLTYIDKWFLYKMRD
P31943 S281 Sugiyama HNRNPH1 HNRPH HNRPH1 GRDLNyCFsGMsDHRyGDGGstFQsttGHCVHMRGLPYRAt
P34932 T649 Sugiyama HSPA4 APG2 HSPH2 RDKLSGEYEKFVSEDDRNsFtLKLEDTENWLyEDGEDQPKQ
P35579 S169 Sugiyama MYH9 HIyAITDtAyRSMMQDREDQsILCTGESGAGKTENTKKVIQ
P35580 S1013 Sugiyama MYH10 QNSKFIKEKKLMEDRIAECssQLAEEEEKAKNLAKIRNKQE
P35580 S1312 Sugiyama MYH10 VsTLLEEAEKKGIKFAKDAAsLEsQLQDtQELLQEETRQKL
P35580 S1315 Sugiyama MYH10 LLEEAEKKGIKFAKDAAsLEsQLQDtQELLQEETRQKLNLS
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40337 S72 Sugiyama VHL EEMEAGRPRPVLRSVNsREPsQVIFCNRsPRVVLPVWLNFD
P40925 S326 Sugiyama MDH1 MDHA NDFSREKMDLTAKELtEEKEsAFEFLssA____________
P40925 S332 Sugiyama MDH1 MDHA KMDLTAKELtEEKEsAFEFLssA__________________
P42696 S90 Sugiyama RBM34 KIAA0117 VYVPVPKQTIKKTKRNEEEEstsQIERPLsQEPAKKVKAKK
P42696 S92 Sugiyama RBM34 KIAA0117 VPVPKQTIKKTKRNEEEEstsQIERPLsQEPAKKVKAKKKH
P43034 S152 Sugiyama PAFAH1B1 LIS1 MDCR MDS PAFAHA IKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADM
P43487 S188 Sugiyama RANBP1 KAGSGKNDHAEKVAEKLEALsVKEETKEDAEEKQ_______
P45974 S783 Sugiyama USP5 ISOT IDDLDAEAAMDISEGRsAADsIsEsVPVGPKVRDGPGKYQL
P47712 S454 Sugiyama PLA2G4A CPLA2 PLA2G4 ssDsDDEsHEPKGtENEDAGsDyQsDNQASWIHRMIMALVS
P47756 S204 Sugiyama CAPZB sGtMNLGGsLtRQMEKDEtVsDCsPHIANIGRLVEDMENKI
P47813 S102 Sugiyama EIF1AX EIF1A EIF4C RDYQDNKADVILKYNADEARsLKAyGELPEHAKINETDTFG
P48643 S270 Sugiyama CCT5 CCTE KIAA0098 ILTCPFEPPKPKTKHKLDVtsVEDyKALQKYEKEKFEEMIQ
P49327 S2198 Sugiyama FASN FAS EVRQLTLRKLQELSSKADEAsELACPtPKEDGLAQQQtQLN
P49368 T486 Sugiyama CCT3 CCTG TRIC5 LRAKHtQENCEtWGVNGEtGtLVDMKELGIWEPLAVKLQTY
P49792 S2493 Sugiyama RANBP2 NUP358 EEtTRERTDVIQGDDVADAtsEVEVsstSEttPKAVVsPPK
P50395 S316 Sugiyama GDI2 RABGDIB QVIRVICILSHPIKNtNDANsCQIIIPQNQVNRKSDIyVCM
P50993 S215 Sugiyama ATP1A2 KIAA0778 DRVPADLRIISSHGCKVDNssLtGESEPQTRSPEFTHENPL
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51532 S699 Sugiyama SMARCA4 BAF190A BRG1 SNF2B SNF2L4 PPTLPVEEKKKIPDPDsDDVsEVDARHIIENAKQDVDDEyG
P53999 S19 Sugiyama SUB1 PC4 RPO2TC1 __MPKSKELVsssssGsDsDsEVDKKLKRKKQVAPEKPVKK
P54105 S210 Sugiyama CLNS1A CLCI ICLN GMLsQsVssQYNMAGVRtEDsIRDyEDGMEVDttPtVAGQF
P54577 S386 Sugiyama YARS1 YARS sRLDIRVGKIITVEKHPDADsLyVEKIDVGEAEPRTVVSGL
P54652 S224 Sugiyama HSPA2 GGGTFDVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHL
P55036 S266 Sugiyama PSMD4 MCB1 AGIATTGtEDsDDALLKMtIsQQEFGRTGLPDLSSMTEEEQ
P55072 S197 Sugiyama VCP HEL-220 HEL-S-70 APDTVIHCEGEPIKREDEEEsLNEVGyDDIGGCRKQLAQIK
P55854 S27 Sugiyama SUMO3 SMT3A SMT3H1 KEGVKTENDHINLKVAGQDGsVVQFKIKRHTPLSKLMKAYC
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 S60 Sugiyama ACTB HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61247 S236 Sugiyama RPS3A FTE1 MFTL KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61916 S29 Sugiyama NPC2 HE1 LLLALSTAAQAEPVQFKDCGsVDGVIKEVNVsPCPtQPCQL
P61956 S28 Sugiyama SUMO2 SMT3B SMT3H2 EGVKtENNDHINLKVAGQDGsVVQFKIKRHTPLSKLMKAYC
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 S62 Sugiyama ACTA2 ACTSA ACTVS GIG46 HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62857 T57 Sugiyama RPS28 DtsRsIIRNVKGPVREGDVLtLLEsEREARRLR________
P62873 S31 Sugiyama GNB1 AEQLKNQIRDARKACADAtLsQItNNIDPVGRIQMRTRRTL
P62873 T34 Sugiyama GNB1 LKNQIRDARKACADAtLsQItNNIDPVGRIQMRTRRTLRGH
P63104 S28 Sugiyama YWHAZ QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63167 T26 Sugiyama DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1 AVIKNADMsEEMQQDsVECAtQALEKYNIEKDIAAHIKKEF
P63220 S68 Sugiyama RPS21 GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 S60 Sugiyama ACTG1 ACTG HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 S61 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 S62 Sugiyama ACTC1 ACTC HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 S62 Sugiyama ACTA1 ACTA HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68363 T73 Sugiyama TUBA1B FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363 Y83 Sugiyama TUBA1B PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
P78368 S26 Sugiyama CSNK1G2 CK1G2 KGGKGETEEGRRMSKAGGGRssHGIRssGTSSGVLMVGPNF
P78368 S27 Sugiyama CSNK1G2 CK1G2 GGKGETEEGRRMSKAGGGRssHGIRssGTSSGVLMVGPNFR
P78368 S32 Sugiyama CSNK1G2 CK1G2 TEEGRRMSKAGGGRssHGIRssGTSSGVLMVGPNFRVGKKI
P78368 S33 Sugiyama CSNK1G2 CK1G2 EEGRRMSKAGGGRssHGIRssGTSSGVLMVGPNFRVGKKIG
P78371 S150 Sugiyama CCT2 99D8.1 CCTB WREATKAAREALLssAVDHGsDEVKFRQDLMNIAGTTLssK
P84022 S418 SIGNOR|PSP SMAD3 MADH3 LHLNGPLQWLDKVLTQMGsPsIRCssVs_____________
Q00839 S59 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 QAALDDEEAGGRPAMEPGNGsLDLGGDsAGRSGAGLEQEAA
Q01082 S2128 Sugiyama SPTBN1 SPTB2 KVsEEAEsQQQWDtsKGEQVsQNGLPAEQGsPRMAETVDTs
Q01105 S133 Sugiyama SET DEEALHYLTRVEVtEFEDIKsGyRIDFyFDENPyFENKVLS
Q01105 S165 Sugiyama SET PyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQ
Q01105 S168 Sugiyama SET ENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQN
Q01105 T169 Sugiyama SET NKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQNK
Q04917 T31 Sugiyama YWHAH YWHA1 ARLAEQAERyDDMAsAMKAVtELNEPLsNEDRNLLsVAyKN
Q06830 S126 Sugiyama PRDX1 PAGA PAGB TDPX2 SDPKRtIAQDyGVLKADEGIsFRGLFIIDDKGILRQItVND
Q07157 S1065 Sugiyama TJP1 ZO1 YVEKQAsRDLEQPtyRyEsssytDQFsRNYEHRLRYEDRVP
Q07666 S150 Sugiyama KHDRBS1 SAM68 EKIQKGDSKKDDEENyLDLFsHKNMKLKERVLIPVKQYPKF
Q12802 S1253 Sugiyama AKAP13 BRX HT31 LBC MVSAQDAPLPKGADLIEEAAsRIVDAVIEQVKAAGALLtEG
Q12802 S1507 Sugiyama AKAP13 BRX HT31 LBC HGsDVSLSQILKPNRSRDRQsLDGFysHGMGAEGRESESEP
Q12805 T219 Sugiyama EFEMP1 FBLN3 FBNL CQCPPGYQKRGEQCVDIDECtIPPYCHQRCVNTPGSFYCQC
Q12888 S598 Sugiyama TP53BP1 QLsQNDDKtKGDDtDtRDDIsILATGCKGREETVAEDVCID
Q12906 S190 Sugiyama ILF3 DRBF MPHOSPH4 NF90 HLTSPVVREEMEKVLAGEtLsVNDPPDVLDRQKCLAALASL
Q13263 S784 Sugiyama TRIM28 KAP1 RNF96 TIF1B DVGRMFKQFNKLTEDKADVQsIIGLQRFFETRMNEAFGDTK
Q13541 S112 Sugiyama EIF4EBP1 EAsQsHLRNsPEDKRAGGEEsQFEMDI______________
Q14151 S234 Sugiyama SAFB2 KIAA0138 EKILDILGEtCKsEPVKEEssELEQPFAQDtssVGPDRKLA
Q14151 S246 Sugiyama SAFB2 KIAA0138 sEPVKEEssELEQPFAQDtssVGPDRKLAEEEDLFDsAHPE
Q14152 S584 Sugiyama EIF3A EIF3S10 KIAA0139 EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14152 S988 Sugiyama EIF3A EIF3S10 KIAA0139 PRRGPEEDRFsRRGADDDRPsWRNTDDDRPPRRIADEDRGN
Q14152 T1378 Sugiyama EIF3A EIF3S10 KIAA0139 AEKDREsLRRTKNEtDEDGWttVRR________________
Q14203 S417 Sugiyama DCTN1 KKNQELEVVRQQRERLQEELsQAEstIDELKEQVDAALGAE
Q14444 S97 Sugiyama CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105 DYQERMNKGERLNQDQLDAVsKyQEVtNNLEFAKELQRsFM
Q14457 S409 EPSD|PSP BECN1 GT197 RFCLPYRMDVEKGKIEDtGGsGGSYSIKTQFNSEEQWTKAL
Q14457 T406 EPSD|PSP BECN1 GT197 GEtRFCLPYRMDVEKGKIEDtGGsGGSYSIKTQFNSEEQWT
Q14498 S334 Sugiyama RBM39 HCC1 RNPC2 FELAGRPMKVGHVTERtDAssAssFLDsDELERtGIDLGtT
Q14498 S337 Sugiyama RBM39 HCC1 RNPC2 AGRPMKVGHVTERtDAssAssFLDsDELERtGIDLGtTGRL
Q14766 S1414 Sugiyama LTBP1 TAEFTEMCPKGKGFVPAGEsssEAGGENyKDADECLLFGQE
Q15181 S127 Sugiyama PPA1 IOPPP PP NDKHTGCCGDNDPIDVCEIGsKVCARGEIIGVKVLGILAMI
Q15185 S118 Sugiyama PTGES3 P23 TEBP WLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGDEDVDL
Q15293 T71 Sugiyama RCN1 RCN EDNQsFQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVDRI
Q15424 S235 Sugiyama SAFB HAP HET SAFB1 EKILDILGEtCKsEPVKEEssELEQPFAQDtssVGPDRKLA
Q15424 S247 Sugiyama SAFB HAP HET SAFB1 sEPVKEEssELEQPFAQDtssVGPDRKLAEEEDLFDsAHPE
Q15758 S539 Sugiyama SLC1A5 ASCT2 M7V1 RDR RDRC PLLKHyRGPAGDAtVAsEKEsVM__________________
Q16643 S255 Sugiyama DBN1 D0S117E HRRKQQTLEAEEAKRRLKEQsIFGDHRDEEEEtHMKKsEsE
Q16643 T267 Sugiyama DBN1 D0S117E AKRRLKEQsIFGDHRDEEEEtHMKKsEsEVEEAAAIIAQRP
Q32M45 S843 Sugiyama ANO4 TMEM16D VNASLSVFRISDFENRSEPEsDGSEFsGtPLKyCRYRDYRD
Q32M45 S849 Sugiyama ANO4 TMEM16D VFRISDFENRSEPEsDGSEFsGtPLKyCRYRDYRDPPHSLV
Q32M45 T851 Sugiyama ANO4 TMEM16D RISDFENRSEPEsDGSEFsGtPLKyCRYRDYRDPPHSLVPY
Q32MZ4 S766 Sugiyama LRRFIP1 GCF2 TRIP sTERCEMSEHPSQTVRKALDsNsLENDDLSAPGREPGHFNP
Q56P03 S55 Sugiyama EAPP C14orf11 BM-036 HGTPDQKRKLIRECLTGESEsssEDEFEKEMEAELNSTMKT
Q58FG1 S251 Sugiyama HSP90AA4P HSP90AD HSPCAL2 EPIDEYCVQQLKEFEGKtLVsVTKEDLELPEDEEEKKKQEE
Q58FG1 T248 Sugiyama HSP90AA4P HSP90AD HSPCAL2 YTIEPIDEYCVQQLKEFEGKtLVsVTKEDLELPEDEEEKKK
Q5JSH3 S199 Sugiyama WDR44 RPH11 EAVEVKGGGDVLEPVssDsLstKDFAAVEEVAPAKPPRHLt
Q5T035 S66 Sugiyama FAM120A2P C9orf129 LSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyERSLPI
Q5T4S7 S2904 Sugiyama UBR4 KIAA0462 KIAA1307 RBAF600 tsPADHGGsVGsEsGGsAVDsVAGEHsVsGRSSAYGDATAE
Q5UIP0 S1693 Sugiyama RIF1 NLRTRNAIKRLHKRDsFDNCsLGESSKIGIsDIssLsEKtF
Q6EEV6 S28 Sugiyama SUMO4 SMT3H4 EEVKTENNNHINLKVAGQDGsVVQFKIKRQTPLSKLMKAYC
Q6NZY4 S605 Sugiyama ZCCHC8 EIFTKKsEAGHAssPDsEVTsLCQKEKAELAPVNTEGALLD
Q6P996 S718 Sugiyama PDXDC1 KIAA0251 KQRLPGQKPFKRsLRGsDALsEtssVsHIEDLEKVERLssG
Q6P996 S722 Sugiyama PDXDC1 KIAA0251 PGQKPFKRsLRGsDALsEtssVsHIEDLEKVERLssGPEQI
Q6P996 S779 Sugiyama PDXDC1 KIAA0251 QHtDQtEAFQKGVPHPEDDHsQVEGPEsLR___________
Q6PCE3 S311 Sugiyama PGM2L1 BM32A QKDPDPDFSTVKCPNPEEGEsVLELsLRLAEKENARVVLAT
Q6PKG0 S627 Sugiyama LARP1 KIAA0731 LARP FLFDEEMEQMDGRKNtFtAWsDEEsDyEIDDRDVNKILIVt
Q6PKG0 S631 Sugiyama LARP1 KIAA0731 LARP EEMEQMDGRKNtFtAWsDEEsDyEIDDRDVNKILIVtQtPH
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6ULP2 S584 Sugiyama AFTPH AFTH AGPSQVVDWNAFEDEQKDsCsWAAFGDQQATESHHRKEAWQ
Q6UN15 S496 Sugiyama FIP1L1 FIP1 RHE DRERERTRERERERDHsPtPsVFNsDEERyRYREYAERGYE
Q6UXH1 S295 Sugiyama CRELD2 UNQ185/PRO211 KECISGYAREHGQCADVDECsLAEKtCVRKNENCYNTPGSY
Q71U36 T73 Sugiyama TUBA1A TUBA3 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36 Y83 Sugiyama TUBA1A TUBA3 PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q7KZF4 S474 Sugiyama SND1 TDRD11 LVSKGLATVIRYRQDDDQRssHyDELLAAEARAIKNGKGLH
Q7Z460 S1216 Sugiyama CLASP1 KIAA0622 MAST1 sQEDLNEPIKRDGKKECDIVsRDGGAAsPAtEGRGGsEVEG
Q7Z5K2 S459 Sugiyama WAPL FOE KIAA0261 WAPAL DEGGsGsSNYKIKyFGFDDLsEsEDDEDDDCQVERKTSKKR
Q86W56 Y832 Sugiyama PARG DDWQRRCTEIVAIDALHFRRyLDQFVPEKMRRELNKAYCGF
Q8IWS0 S183 Sugiyama PHF6 CENP-31 KIAA1823 RKGRPRKTNFKGLSEDtRstssHGtDEMEsssyRDRsPHRs
Q8IWS0 S184 Sugiyama PHF6 CENP-31 KIAA1823 KGRPRKTNFKGLSEDtRstssHGtDEMEsssyRDRsPHRss
Q8N6T3 S348 Sugiyama ARFGAP1 ARF1GAP FWETFGSAEPTKtRKsPssDsWtCADtstERRssDsWEVWG
Q8N6T3 T350 Sugiyama ARFGAP1 ARF1GAP ETFGSAEPTKtRKsPssDsWtCADtstERRssDsWEVWGSA
Q8NBJ7 S283 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 GsANHRARVttRMGNtPDsAsDNLGFRCAADAGRPPGEL__
Q8NBS9 S129 Sugiyama TXNDC5 TLP46 UNQ364/PRO700 MEDAKVYVAKVDCtAHsDVCsAQGVRGYPTLKLFKPGQEAV
Q8ND56 S374 Sugiyama LSM14A C19orf13 FAM61A RAP55 RAP55A EDPLGPNCYYDKTKsFFDNIsCDDNRERRPtWAEERRLNAE
Q8NE71 S595 Sugiyama ABCF1 ABC50 TKEALTRKQQKCRRKNQDEEsQEAPELLKRPKEYTVRFTFP
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8TF05 S547 Sugiyama PPP4R1 MEG1 PP4R1 VEVLSAALRAssLDAHEEtIsIEKRSDLQDELDINELPNCK
Q8WVV9 T46 Sugiyama HNRNPLL HNRPLL SRRF BLOCK24 KTEEGEIDysAEEGENRREAtPRGGGDGGGGGRsFsQPEAG
Q92598 S852 Sugiyama HSPH1 HSP105 HSP110 KIAA0201 NNFGAEPPHQNGECyPNEKNsVNMDLD______________
Q92785 S142 Sugiyama DPF2 BAF45D REQ UBID4 LLRTDPLEKRGAPDPRVDDDsLGEFPVTNsRARKRILEPDD
Q93062 S14 Sugiyama RBPMS HERMES _______MNNGGKAEKENtPsEANLQEEEVRTLFVSGLPLD
Q96CT7 S122 Sugiyama CCDC124 DtLRRDHQLREAPDTAEKAKsHLEVPLEENVNRRVLEEGsV
Q96E11 S227 Sugiyama MRRF SLRKVRTNSMNKLKKSKDTVsEDtIRLIEKQIsQMADDtVA
Q96E11 T230 Sugiyama MRRF KVRTNSMNKLKKSKDTVsEDtIRLIEKQIsQMADDtVAELD
Q96GM8 S374 Sugiyama TOE1 GTQtsGEAKDGPPKKQVCGDsIKPEETEQEVAADETRNLPH
Q96K76 S865 Sugiyama USP47 AGGDSGNVDDDCERVKGPVGsLKsVEAILEEstEKLKSLSL
Q96K76 S868 Sugiyama USP47 DSGNVDDDCERVKGPVGsLKsVEAILEEstEKLKSLSLQQQ
Q96KB5 S298 Sugiyama PBK TOPK RPPINMEELDESYQKVIELFsVCtNEDPKDRPsAAHIVEAL
Q96KB5 T301 Sugiyama PBK TOPK INMEELDESYQKVIELFsVCtNEDPKDRPsAAHIVEALEtD
Q96SB4 S334 Sugiyama SRPK1 ERPLKENPPNKMtQEKLEEsstIGQDQtLMERDTEGGAAEI
Q99614 S90 Sugiyama TTC1 TPR1 FEEEPGADKVENKsNEDVNssELDEEyLIELEKNMSDEEKQ
Q99733 S121 Sugiyama NAP1L4 NAP2 PLFDKRREFItGDVEPtDAEsEWHsENEEEEKLAGDMKSKV
Q99733 S125 Sugiyama NAP1L4 NAP2 KRREFItGDVEPtDAEsEWHsENEEEEKLAGDMKSKVVVTE
Q99848 S269 Sugiyama EBNA1BP2 EBP2 GFGGKKKGSKWNtREsyDDVssFRAKTAHGRGLKRPGKKGS
Q99848 S270 Sugiyama EBNA1BP2 EBP2 FGGKKKGSKWNtREsyDDVssFRAKTAHGRGLKRPGKKGSN
Q9BQE3 T73 Sugiyama TUBA1C TUBA6 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3 Y83 Sugiyama TUBA1C TUBA6 PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q9BTC0 S352 Sugiyama DIDO1 C20orf158 DATF1 KIAA0333 TADQQEAKWRPGDADGTDCTsIGtIEQKSSEDQGIKGRIEK
Q9BTC0 T355 Sugiyama DIDO1 C20orf158 DATF1 KIAA0333 QQEAKWRPGDADGTDCTsIGtIEQKSSEDQGIKGRIEKAAN
Q9BVS4 S332 Sugiyama RIOK2 RIO2 DDELLHPLGPDDKNIETKEGsEFsFsDGEVAEKAEVyGsEN
Q9BVS4 S335 Sugiyama RIOK2 RIO2 LLHPLGPDDKNIETKEGsEFsFsDGEVAEKAEVyGsENEsE
Q9BVS4 S412 Sugiyama RIOK2 RIO2 EMTEFNQALEEIKGQVVENNsVTEFsEEKNRTENYNRQDGQ
Q9BWU0 S709 Sugiyama SLC4A1AP HLC3 SRGELKKKKTPGPGKLPPTLsSKYPEDDPDYCVWVPPEGQS
Q9BY32 S53 Sugiyama ITPA C20orf37 My049 OK/SW-cl.9 CTLVAQKIDLPEyQGEPDEIsIQKCQEAVRQVQGPVLVEDT
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9C0C2 S1174 Sugiyama TNKS1BP1 KIAA1741 TAB182 ttAGsVDWTDQLGLRNLEVssCVGsGGssEAREsAVGQMGW
Q9H1E3 S132 Sugiyama NUCKS1 NUCKS JC7 GsEEEQEEEDEAPFQEKDsGsDEDFLMEDDDDsDyGSsKKK
Q9H2U2 S309 Sugiyama PPA2 HSPC124 NCTNVQISDSPFRCtQEEARsLVEsVsssPNKEsNEEEQVW
Q9H2U2 S313 Sugiyama PPA2 HSPC124 VQISDSPFRCtQEEARsLVEsVsssPNKEsNEEEQVWHFLG
Q9H6T3 S507 Sugiyama RPAP3 PTsDtPRAKVLKIEEVsDTssLQPQAsLKQDVCQsYsEKMP
Q9H8Y5 S126 Sugiyama ANKZF1 ZNF744 DKPLLSALDFEKQSSTGDLSsISGSEDSDSASEEDLQTLDR
Q9NQX3 S262 Sugiyama GPHN GPH KIAA1385 AKIPDSIISRGVQVLPRDTAsLsttPsEsPRAQAtsRLstA
Q9NR30 S466 Sugiyama DDX21 ETKKEAQELSQNsAIKQDAQsLHGDIPQKQREITLKGFRNG
Q9NW13 S200 Sugiyama RBM28 KGRTVAVDWAVAKDKYKDTQsVsAIGEEKSHESKHQESVKK
Q9NX58 S32 Sugiyama LYAR PNAS-5 sVKKIQVEKHVSVCRNCECLsCIDCGKDFWGDDYKNHVKCI
Q9NYL9 S25 Sugiyama TMOD3 FRKDLEKyKDLDEDELLGNLsEtELKQLETVLDDLDPENAL
Q9NZB2 S417 Sugiyama FAM120A C9orf10 KIAA0183 OSSA LSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyERssPI
Q9NZL9 S110 Sugiyama MAT2B TGR MSTP045 Nbla02999 UNQ2435/PRO4995 IVHCAAERRPDVVENQPDAAsQLNVDASGNLAKEAAAVGAF
Q9P2E9 S1122 Sugiyama RRBP1 KIAA1398 APAEPSSDLASKLREAEEtQstLQAECDQYRSILAETEGML
Q9P2E9 T1120 Sugiyama RRBP1 KIAA1398 PPAPAEPSSDLASKLREAEEtQstLQAECDQYRSILAETEG
Q9UPN9 S787 Sugiyama TRIM33 KIAA1113 RFG7 TIF1G SFKSDQVKVKQEPGTEDEICsFsGGVKQEKTEDGRRsACML
Q9UPQ9 S992 Sugiyama TNRC6B KIAA1093 TTGWGNTPANAPNAMKPNSKsMQDGWGESDGPVTGARHPsW
Q9UQ80 S40 Sugiyama PA2G4 EBP1 KYKMGGDIANRVLRsLVEASssGVsVLsLCEKGDAMIMEEt
Q9UQ80 S44 Sugiyama PA2G4 EBP1 GGDIANRVLRsLVEASssGVsVLsLCEKGDAMIMEEtGKIF
Q9UQ80 S47 Sugiyama PA2G4 EBP1 IANRVLRsLVEASssGVsVLsLCEKGDAMIMEEtGKIFKKE
Q9Y266 S285 Sugiyama NUDC NtKKINPENsKLsDLDsEtRsMVEKMMYDQRQKsMGLPtsD
Q9Y2B0 S63 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 AQVDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLE
Q9Y383 S347 Sugiyama LUC7L2 CGI-59 CGI-74 SRERSKRRSSKERFRDQDLAsCDRDRssRDRSPRDRDRKDK
Q9Y3Z3 S603 Sugiyama SAMHD1 MOP5 DGDVIAPLItPQKKEWNDstsVQNPtRLREASKSRVQLFKD
Q9Y5M8 S257 Sugiyama SRPRB PSEC0230 LPLKVEFLECSAKGGRGDVGsADIQDLEKWLAKIA______
Q9Y5P4 S132 SIGNOR|EPSD|PSP CERT1 CERT COL4A3BP STARD11 IEQHKTESGYGsEssLRRHGsMVsLVSGAsGYsAtstssFK
Q9Y5S9 S56 Sugiyama RBM8A RBM8 HSPC114 MDS014 KGRGFGsEEGsRARMREDyDsVEQDGDEPGPQRSVEGWILF
Q9Y696 S31 Sugiyama CLIC4 KEEDKEPLIELFVKAGsDGEsIGNCPFSQRLFMILWLKGVV
Q9Y6A5 S583 Sugiyama TACC3 ERIC1 FDPLLRDsPGRPVPVATEtssMHGANEtPSGRPREAKLVEF
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Signal Transduction R-HSA-162582 3.514269e-10 9.454 1 0
Cell-Cell communication R-HSA-1500931 1.739215e-08 7.760 0 0
Mitotic Prophase R-HSA-68875 2.640877e-08 7.578 0 0
M Phase R-HSA-68886 7.330511e-08 7.135 0 0
Cell Cycle, Mitotic R-HSA-69278 8.034833e-08 7.095 0 0
Chromatin organization R-HSA-4839726 7.633932e-08 7.117 0 0
Cell Cycle R-HSA-1640170 2.641690e-07 6.578 0 0
Nuclear Envelope Breakdown R-HSA-2980766 3.311109e-07 6.480 0 0
Cell junction organization R-HSA-446728 3.722925e-07 6.429 0 0
Chromatin modifying enzymes R-HSA-3247509 8.597261e-07 6.066 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 8.180595e-07 6.087 0 0
HATs acetylate histones R-HSA-3214847 2.448550e-06 5.611 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.815305e-06 5.550 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.815305e-06 5.550 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.871865e-06 5.412 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 6.008884e-06 5.221 0 0
Meiotic synapsis R-HSA-1221632 6.543039e-06 5.184 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 7.492901e-06 5.125 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 9.608253e-06 5.017 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.018324e-05 4.992 0 0
Cell-cell junction organization R-HSA-421270 1.038608e-05 4.984 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.268088e-05 4.897 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.441631e-05 4.841 0 0
Deubiquitination R-HSA-5688426 1.503901e-05 4.823 0 0
Adherens junctions interactions R-HSA-418990 1.715978e-05 4.765 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.742731e-05 4.759 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.911920e-05 4.719 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.812414e-05 4.551 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.845345e-05 4.546 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.997376e-05 4.523 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 3.126293e-05 4.505 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 4.505516e-05 4.346 0 0
Mitotic Prometaphase R-HSA-68877 5.564024e-05 4.255 0 0
Cellular Senescence R-HSA-2559583 6.901284e-05 4.161 0 0
Ub-specific processing proteases R-HSA-5689880 7.295120e-05 4.137 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 7.405384e-05 4.130 0 0
Cell Cycle Checkpoints R-HSA-69620 7.636826e-05 4.117 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 8.223480e-05 4.085 0 0
Meiosis R-HSA-1500620 8.011631e-05 4.096 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 9.154262e-05 4.038 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.036344e-04 3.984 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.196027e-04 3.922 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.297086e-04 3.887 0 0
Signaling by EGFR R-HSA-177929 1.326682e-04 3.877 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.612797e-04 3.792 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.612797e-04 3.792 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.612797e-04 3.792 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.653597e-04 3.782 0 0
Nucleosome assembly R-HSA-774815 1.653597e-04 3.782 0 0
Gene Silencing by RNA R-HSA-211000 1.693140e-04 3.771 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.698311e-04 3.770 0 0
Long-term potentiation R-HSA-9620244 1.848197e-04 3.733 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.936833e-04 3.713 0 0
Apoptotic execution phase R-HSA-75153 2.013405e-04 3.696 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.172849e-04 3.663 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.172849e-04 3.663 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.099244e-04 3.678 0 0
snRNP Assembly R-HSA-191859 2.246287e-04 3.649 0 0
Metabolism of non-coding RNA R-HSA-194441 2.246287e-04 3.649 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.365104e-04 3.626 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.366738e-04 3.626 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.656882e-04 3.576 0 0
Membrane Trafficking R-HSA-199991 2.810331e-04 3.551 0 0
Packaging Of Telomere Ends R-HSA-171306 3.121362e-04 3.506 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 3.121362e-04 3.506 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.466599e-04 3.460 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.466599e-04 3.460 0 0
HDACs deacetylate histones R-HSA-3214815 3.352165e-04 3.475 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 4.326601e-04 3.364 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 4.326601e-04 3.364 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.438054e-04 3.353 0 0
DNA methylation R-HSA-5334118 5.063800e-04 3.296 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 5.404477e-04 3.267 0 0
HIV Life Cycle R-HSA-162587 5.654118e-04 3.248 0 0
Nuclear import of Rev protein R-HSA-180746 5.359918e-04 3.271 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 5.359918e-04 3.271 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 6.425343e-04 3.192 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 6.593182e-04 3.181 0 0
Reproduction R-HSA-1474165 6.680984e-04 3.175 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 6.962760e-04 3.157 0 0
G2/M DNA damage checkpoint R-HSA-69473 7.984467e-04 3.098 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 9.123133e-04 3.040 0 0
ISG15 antiviral mechanism R-HSA-1169408 9.131960e-04 3.039 0 0
MTOR signalling R-HSA-165159 9.433211e-04 3.025 0 0
G2/M Checkpoints R-HSA-69481 9.548241e-04 3.020 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.797771e-04 3.009 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.065884e-03 2.972 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.065324e-03 2.973 0 0
Defective pyroptosis R-HSA-9710421 1.123830e-03 2.949 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.132930e-03 2.946 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.201913e-03 2.920 0 0
Regulation of CDH1 Function R-HSA-9764561 1.300406e-03 2.886 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.321946e-03 2.879 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.323206e-03 2.878 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.345597e-03 2.871 0 0
Meiotic recombination R-HSA-912446 1.438817e-03 2.842 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.489357e-03 2.827 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.489357e-03 2.827 0 0
Mitotic Anaphase R-HSA-68882 1.563458e-03 2.806 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.571914e-03 2.804 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.677672e-03 2.775 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.003032e-03 2.698 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.846193e-03 2.734 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.846193e-03 2.734 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.846193e-03 2.734 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.751294e-03 2.757 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.940441e-03 2.712 0 0
Signaling by RAS mutants R-HSA-6802949 1.846193e-03 2.734 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.003714e-03 2.698 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 2.003032e-03 2.698 0 0
Nervous system development R-HSA-9675108 1.975778e-03 2.704 0 0
Signaling by ALK in cancer R-HSA-9700206 2.003714e-03 2.698 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.804340e-03 2.744 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.846193e-03 2.734 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.721709e-03 2.764 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 2.003032e-03 2.698 0 0
DNA Double Strand Break Response R-HSA-5693606 2.005555e-03 2.698 0 0
ESR-mediated signaling R-HSA-8939211 2.086696e-03 2.681 0 0
Cellular response to heat stress R-HSA-3371556 2.130029e-03 2.672 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.130029e-03 2.672 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 2.150137e-03 2.668 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.261692e-03 2.646 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.364254e-03 2.626 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.402315e-03 2.619 0 0
Negative regulation of MET activity R-HSA-6807004 2.538423e-03 2.595 0 0
EGFR downregulation R-HSA-182971 2.663588e-03 2.575 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.742563e-03 2.562 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.611781e-03 2.583 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 2.776891e-03 2.556 0 0
Depyrimidination R-HSA-73928 2.776891e-03 2.556 0 0
Axon guidance R-HSA-422475 2.900599e-03 2.538 0 0
NRAGE signals death through JNK R-HSA-193648 2.975182e-03 2.526 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 3.019196e-03 2.520 0 0
Cleavage of the damaged purine R-HSA-110331 3.019196e-03 2.520 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 3.196193e-03 2.495 0 0
HIV Infection R-HSA-162906 3.280481e-03 2.484 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.299608e-03 2.482 0 0
Death Receptor Signaling R-HSA-73887 3.299608e-03 2.482 0 0
Depurination R-HSA-73927 3.565314e-03 2.448 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.719180e-03 2.430 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.777495e-03 2.423 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.804189e-03 2.420 0 0
Mitotic Spindle Checkpoint R-HSA-69618 4.115064e-03 2.386 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.442025e-03 2.352 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 4.615384e-03 2.336 0 0
TCF dependent signaling in response to WNT R-HSA-201681 4.805041e-03 2.318 1 0
mTORC1-mediated signalling R-HSA-166208 4.963322e-03 2.304 0 0
DNA Replication Pre-Initiation R-HSA-69002 5.051817e-03 2.297 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 5.457137e-03 2.263 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 5.468744e-03 2.262 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.654841e-03 2.248 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 6.004640e-03 2.222 0 0
tRNA processing in the nucleus R-HSA-6784531 6.372233e-03 2.196 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 6.842523e-03 2.165 0 0
HCMV Early Events R-HSA-9609690 6.473870e-03 2.189 0 0
Separation of Sister Chromatids R-HSA-2467813 6.869303e-03 2.163 0 0
Activation of HOX genes during differentiation R-HSA-5619507 6.536197e-03 2.185 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 6.536197e-03 2.185 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 6.779971e-03 2.169 0 0
Signaling by PTK6 R-HSA-8848021 7.160587e-03 2.145 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 7.160587e-03 2.145 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 6.996839e-03 2.155 0 0
MAPK family signaling cascades R-HSA-5683057 7.209468e-03 2.142 0 0
Inositol phosphate metabolism R-HSA-1483249 6.570014e-03 2.182 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 7.561716e-03 2.121 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 8.189946e-03 2.087 0 0
Chromosome Maintenance R-HSA-73886 8.365222e-03 2.078 0 0
Epigenetic regulation of gene expression R-HSA-212165 8.367515e-03 2.077 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 8.597860e-03 2.066 0 0
Signaling by MET R-HSA-6806834 8.820075e-03 2.055 0 0
TGFBR3 expression R-HSA-9839394 8.857614e-03 2.053 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 8.857614e-03 2.053 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 8.857614e-03 2.053 0 0
DCC mediated attractive signaling R-HSA-418885 8.971925e-03 2.047 0 0
Cell-extracellular matrix interactions R-HSA-446353 8.971925e-03 2.047 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 8.971925e-03 2.047 0 0
Diseases of programmed cell death R-HSA-9645723 9.930228e-03 2.003 0 0
PECAM1 interactions R-HSA-210990 1.017361e-02 1.993 0 0
MET interacts with TNS proteins R-HSA-8875513 1.146885e-02 1.940 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.123118e-02 1.950 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.071635e-02 1.970 0 0
Nuclear RNA decay R-HSA-9930044 1.123118e-02 1.950 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.188428e-02 1.925 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.177876e-02 1.929 0 0
Host Interactions of HIV factors R-HSA-162909 1.055085e-02 1.977 0 0
L1CAM interactions R-HSA-373760 1.072714e-02 1.970 0 0
Protein ubiquitination R-HSA-8852135 1.152388e-02 1.938 0 0
Homology Directed Repair R-HSA-5693538 1.250794e-02 1.903 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.270634e-02 1.896 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.283212e-02 1.892 0 0
Telomere Maintenance R-HSA-157579 1.299195e-02 1.886 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.300794e-02 1.886 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.303596e-02 1.885 0 0
HCMV Late Events R-HSA-9610379 1.334214e-02 1.875 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.355449e-02 1.868 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.355449e-02 1.868 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.355449e-02 1.868 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.355449e-02 1.868 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.386716e-02 1.858 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.431050e-02 1.844 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.435715e-02 1.843 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.449314e-02 1.839 0 0
G alpha (12/13) signalling events R-HSA-416482 1.535309e-02 1.814 0 0
RNA Polymerase I Transcription R-HSA-73864 1.535309e-02 1.814 0 0
MAP2K and MAPK activation R-HSA-5674135 1.694498e-02 1.771 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.712334e-02 1.766 0 0
Signaling by Hippo R-HSA-2028269 1.724350e-02 1.763 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.784561e-02 1.748 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.853466e-02 1.732 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.853466e-02 1.732 0 0
Type I hemidesmosome assembly R-HSA-446107 1.958421e-02 1.708 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.958421e-02 1.708 0 0
Formation of annular gap junctions R-HSA-196025 1.958421e-02 1.708 0 0
Ephrin signaling R-HSA-3928664 2.088557e-02 1.680 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.984977e-02 1.702 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.003509e-02 1.698 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.984977e-02 1.702 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.851459e-02 1.732 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.970693e-02 1.705 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.958421e-02 1.708 0 0
Signaling by WNT R-HSA-195721 2.151672e-02 1.667 1 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.244878e-02 1.649 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.252405e-02 1.647 0 0
Base Excision Repair R-HSA-73884 2.352002e-02 1.629 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 2.531930e-02 1.597 0 0
Gap junction degradation R-HSA-190873 2.584881e-02 1.588 0 0
Unwinding of DNA R-HSA-176974 2.584881e-02 1.588 0 0
Signaling by ERBB2 R-HSA-1227986 2.593609e-02 1.586 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 2.665696e-02 1.574 0 0
Regulation of KIT signaling R-HSA-1433559 2.665696e-02 1.574 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.710833e-02 1.567 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.809533e-02 1.551 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.842491e-02 1.546 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.864139e-02 1.543 0 0
HCMV Infection R-HSA-9609646 2.960434e-02 1.529 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.965706e-02 1.528 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.985828e-02 1.525 0 0
Integrin signaling R-HSA-354192 2.985828e-02 1.525 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.985828e-02 1.525 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.985828e-02 1.525 0 0
Vesicle-mediated transport R-HSA-5653656 2.991064e-02 1.524 0 0
DNA Replication R-HSA-69306 3.001016e-02 1.523 0 0
Apoptosis R-HSA-109581 3.026685e-02 1.519 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.164403e-02 1.500 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 3.247867e-02 1.488 0 0
Interaction between L1 and Ankyrins R-HSA-445095 3.493348e-02 1.457 0 0
Striated Muscle Contraction R-HSA-390522 3.384912e-02 1.470 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 3.818712e-02 1.418 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.214833e-02 1.493 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.569749e-02 1.447 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 3.846711e-02 1.415 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 3.846711e-02 1.415 0 0
Ion transport by P-type ATPases R-HSA-936837 3.739963e-02 1.427 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 3.401114e-02 1.468 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 3.385521e-02 1.470 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 3.846711e-02 1.415 0 0
Signaling by VEGF R-HSA-194138 3.826932e-02 1.417 0 0
Gene expression (Transcription) R-HSA-74160 3.206516e-02 1.494 0 0
PKMTs methylate histone lysines R-HSA-3214841 3.594221e-02 1.444 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.318825e-02 1.479 0 0
Amyloid fiber formation R-HSA-977225 3.918992e-02 1.407 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 3.954544e-02 1.403 0 0
Signaling by FGFR1 in disease R-HSA-5655302 4.003197e-02 1.398 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 4.532693e-02 1.344 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 4.566967e-02 1.340 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 4.634202e-02 1.334 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 4.634202e-02 1.334 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 5.115863e-02 1.291 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 5.119405e-02 1.291 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.119405e-02 1.291 0 0
Interleukin-37 signaling R-HSA-9008059 5.119405e-02 1.291 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 5.125187e-02 1.290 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 5.127656e-02 1.290 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 5.300713e-02 1.276 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 5.300713e-02 1.276 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 5.300713e-02 1.276 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 5.300713e-02 1.276 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 5.300713e-02 1.276 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 5.300713e-02 1.276 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 5.300713e-02 1.276 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 5.300713e-02 1.276 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 5.300713e-02 1.276 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 5.300713e-02 1.276 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 5.300713e-02 1.276 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 5.300713e-02 1.276 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 5.380708e-02 1.269 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 5.399833e-02 1.268 0 0
EPH-Ephrin signaling R-HSA-2682334 5.407166e-02 1.267 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 5.440776e-02 1.264 0 0
Specification of primordial germ cells R-HSA-9827857 5.440776e-02 1.264 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 6.587453e-02 1.181 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 6.587453e-02 1.181 0 0
Chaperone Mediated Autophagy R-HSA-9613829 6.323447e-02 1.199 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 6.323447e-02 1.199 0 0
Sema4D in semaphorin signaling R-HSA-400685 6.911849e-02 1.160 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 5.891851e-02 1.230 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 5.623421e-02 1.250 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 5.949765e-02 1.226 0 0
DNA strand elongation R-HSA-69190 6.430493e-02 1.192 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 5.891851e-02 1.230 0 0
Semaphorin interactions R-HSA-373755 6.758801e-02 1.170 0 0
Trafficking of AMPA receptors R-HSA-399719 5.751839e-02 1.240 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 6.911849e-02 1.160 0 0
Signaling by Nuclear Receptors R-HSA-9006931 5.996850e-02 1.222 0 0
PTEN Regulation R-HSA-6807070 5.705930e-02 1.244 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 6.731065e-02 1.172 0 0
Heme signaling R-HSA-9707616 6.254970e-02 1.204 0 0
S Phase R-HSA-69242 5.985748e-02 1.223 0 0
Cellular responses to stress R-HSA-2262752 5.780848e-02 1.238 0 0
Rab regulation of trafficking R-HSA-9007101 6.340853e-02 1.198 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 6.539061e-02 1.184 0 0
Signaling by TGFBR3 R-HSA-9839373 6.516932e-02 1.186 0 0
Signaling by NTRKs R-HSA-166520 5.985748e-02 1.223 0 0
Interleukin-7 signaling R-HSA-1266695 6.911849e-02 1.160 0 0
Post NMDA receptor activation events R-HSA-438064 6.443712e-02 1.191 0 0
SARS-CoV-2-host interactions R-HSA-9705683 5.667935e-02 1.247 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 6.988230e-02 1.156 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 7.015001e-02 1.154 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 7.015001e-02 1.154 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 7.155639e-02 1.145 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 7.155639e-02 1.145 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 7.155639e-02 1.145 0 0
DNA Repair R-HSA-73894 7.415923e-02 1.130 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 7.474017e-02 1.126 0 0
Cellular responses to stimuli R-HSA-8953897 7.618755e-02 1.118 0 0
NGF-stimulated transcription R-HSA-9031628 7.750464e-02 1.111 0 0
Signaling by FGFR1 amplification mutants R-HSA-1839120 7.807836e-02 1.107 0 0
MET activates STAT3 R-HSA-8875791 7.807836e-02 1.107 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 7.807836e-02 1.107 0 0
Co-inhibition by PD-1 R-HSA-389948 8.044807e-02 1.094 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 8.056621e-02 1.094 0 0
MET receptor recycling R-HSA-8875656 8.214445e-02 1.085 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 8.214445e-02 1.085 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 8.314765e-02 1.080 0 0
Nephrin family interactions R-HSA-373753 8.314765e-02 1.080 0 0
Degradation of CDH1 R-HSA-9766229 8.417138e-02 1.075 0 0
AURKA Activation by TPX2 R-HSA-8854518 8.423702e-02 1.074 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 8.775720e-02 1.057 0 0
PDGFR mutants bind TKIs R-HSA-9674428 8.775720e-02 1.057 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 8.775720e-02 1.057 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 8.775720e-02 1.057 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 8.775720e-02 1.057 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 8.775720e-02 1.057 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 8.775720e-02 1.057 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 8.775720e-02 1.057 0 0
Regulation of gap junction activity R-HSA-191650 1.060433e-01 0.975 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.060433e-01 0.975 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 9.995053e-02 1.000 0 0
ARMS-mediated activation R-HSA-170984 9.995053e-02 1.000 0 0
ALK mutants bind TKIs R-HSA-9700645 9.995053e-02 1.000 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.145945e-01 0.941 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.145945e-01 0.941 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.059776e-01 0.975 0 0
HIV elongation arrest and recovery R-HSA-167287 9.658210e-02 1.015 0 0
Pausing and recovery of HIV elongation R-HSA-167290 9.658210e-02 1.015 0 0
Late endosomal microautophagy R-HSA-9615710 1.068578e-01 0.971 0 0
RAF activation R-HSA-5673000 8.745392e-02 1.058 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 9.405987e-02 1.027 0 0
mRNA 3'-end processing R-HSA-72187 1.061636e-01 0.974 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.086426e-01 0.964 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 1.045274e-01 0.981 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.009739e-01 0.996 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.009739e-01 0.996 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.009739e-01 0.996 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 1.145945e-01 0.941 0 0
Oncogene Induced Senescence R-HSA-2559585 9.609446e-02 1.017 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.060433e-01 0.975 0 0
NADE modulates death signalling R-HSA-205025 1.060433e-01 0.975 0 0
Developmental Cell Lineages R-HSA-9734767 1.019430e-01 0.992 0 0
p75NTR signals via NF-kB R-HSA-193639 9.993317e-02 1.000 0 0
Autophagy R-HSA-9612973 8.727617e-02 1.059 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.068578e-01 0.971 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 9.995053e-02 1.000 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.068578e-01 0.971 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 1.068578e-01 0.971 0 0
Regulation of TP53 Activity R-HSA-5633007 1.036711e-01 0.984 0 0
MAP kinase activation R-HSA-450294 1.086426e-01 0.964 0 0
RNA Polymerase II Transcription R-HSA-73857 9.029960e-02 1.044 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 9.995053e-02 1.000 0 0
TBC/RABGAPs R-HSA-8854214 1.021927e-01 0.991 0 0
Signal regulatory protein family interactions R-HSA-391160 8.621120e-02 1.064 0 0
Muscle contraction R-HSA-397014 9.220900e-02 1.035 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.039101e-01 0.983 0 0
Netrin-1 signaling R-HSA-373752 1.107051e-01 0.956 0 0
Potential therapeutics for SARS R-HSA-9679191 1.011089e-01 0.995 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 8.631101e-02 1.064 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 9.993317e-02 1.000 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 8.612102e-02 1.065 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 9.572205e-02 1.019 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.011089e-01 0.995 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.173741e-01 0.930 0 0
Activation of the pre-replicative complex R-HSA-68962 1.176733e-01 0.929 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.191443e-01 0.924 0 0
Regulation of CDH11 function R-HSA-9762292 1.191443e-01 0.924 0 0
Signaling by Leptin R-HSA-2586552 1.191443e-01 0.924 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.191443e-01 0.924 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.239584e-01 0.907 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.239584e-01 0.907 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.244869e-01 0.905 0 0
Nucleotide Excision Repair R-HSA-5696398 1.273221e-01 0.895 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.289922e-01 0.889 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.301362e-01 0.886 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.301362e-01 0.886 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.356133e-01 0.868 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.356133e-01 0.868 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.356133e-01 0.868 0 0
IRS activation R-HSA-74713 1.362016e-01 0.866 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 1.362016e-01 0.866 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.362016e-01 0.866 0 0
G2 Phase R-HSA-68911 1.362016e-01 0.866 0 0
NrCAM interactions R-HSA-447038 1.362016e-01 0.866 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 1.376085e-01 0.861 0 0
Recycling pathway of L1 R-HSA-437239 1.384548e-01 0.859 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.395698e-01 0.855 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.395698e-01 0.855 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 1.395698e-01 0.855 0 0
Signaling by FGFR in disease R-HSA-1226099 1.399235e-01 0.854 0 0
Ion homeostasis R-HSA-5578775 1.400218e-01 0.854 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.452658e-01 0.838 0 0
Deadenylation of mRNA R-HSA-429947 1.452658e-01 0.838 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.452658e-01 0.838 0 0
Generation of second messenger molecules R-HSA-202433 1.459196e-01 0.836 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.464776e-01 0.834 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 1.464938e-01 0.834 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.678178e-01 0.775 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.678178e-01 0.775 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.678178e-01 0.775 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.678178e-01 0.775 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 1.678178e-01 0.775 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.678178e-01 0.775 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.678178e-01 0.775 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.408565e-01 0.618 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.408565e-01 0.618 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 2.408565e-01 0.618 0 0
Defective SLC34A2 causes PALM R-HSA-5687583 2.408565e-01 0.618 0 0
Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) R-HSA-5619045 2.408565e-01 0.618 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.679537e-01 0.775 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.679537e-01 0.775 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 1.679537e-01 0.775 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.074886e-01 0.512 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 3.074886e-01 0.512 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.074886e-01 0.512 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.074886e-01 0.512 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.074886e-01 0.512 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 2.007880e-01 0.697 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.007880e-01 0.697 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 2.007880e-01 0.697 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 1.610683e-01 0.793 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.610683e-01 0.793 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 1.610683e-01 0.793 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.342704e-01 0.630 0 0
SOS-mediated signalling R-HSA-112412 2.342704e-01 0.630 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 2.342704e-01 0.630 0 0
Disinhibition of SNARE formation R-HSA-114516 2.342704e-01 0.630 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 2.342704e-01 0.630 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.342704e-01 0.630 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 3.682759e-01 0.434 0 0
PLC-gamma1 signalling R-HSA-167021 3.682759e-01 0.434 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 3.682759e-01 0.434 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 3.682759e-01 0.434 0 0
Signalling to STAT3 R-HSA-198745 3.682759e-01 0.434 0 0
MET activates PTPN11 R-HSA-8865999 3.682759e-01 0.434 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 3.682759e-01 0.434 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 3.682759e-01 0.434 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.834812e-01 0.736 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.834812e-01 0.736 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 2.680347e-01 0.572 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 2.680347e-01 0.572 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 2.680347e-01 0.572 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 2.680347e-01 0.572 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.066533e-01 0.685 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.066533e-01 0.685 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 2.066533e-01 0.685 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.635986e-01 0.786 0 0
Regulation of signaling by CBL R-HSA-912631 1.813788e-01 0.741 0 0
Lipophagy R-HSA-9613354 3.017736e-01 0.520 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 3.017736e-01 0.520 0 0
WNT mediated activation of DVL R-HSA-201688 3.017736e-01 0.520 0 0
Calcineurin activates NFAT R-HSA-2025928 3.017736e-01 0.520 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 4.237307e-01 0.373 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.237307e-01 0.373 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.237307e-01 0.373 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.237307e-01 0.373 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.237307e-01 0.373 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.237307e-01 0.373 0 0
Tight junction interactions R-HSA-420029 1.595770e-01 0.797 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.997608e-01 0.699 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.997608e-01 0.699 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.546812e-01 0.594 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.546812e-01 0.594 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 2.546812e-01 0.594 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 1.744325e-01 0.758 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 3.352318e-01 0.475 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 3.352318e-01 0.475 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 3.352318e-01 0.475 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 2.056091e-01 0.687 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 3.040397e-01 0.517 0 0
Signaling by APC mutants R-HSA-4839744 3.681988e-01 0.434 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 3.681988e-01 0.434 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 3.681988e-01 0.434 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 3.681988e-01 0.434 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 3.289077e-01 0.483 0 0
HSF1-dependent transactivation R-HSA-3371571 1.802683e-01 0.744 0 0
MET promotes cell motility R-HSA-8875878 2.358041e-01 0.627 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 4.005032e-01 0.397 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 4.005032e-01 0.397 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.005032e-01 0.397 0 0
Activation of RAC1 R-HSA-428540 4.005032e-01 0.397 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 4.005032e-01 0.397 0 0
Signaling by GSK3beta mutants R-HSA-5339716 4.005032e-01 0.397 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.659627e-01 0.575 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.659627e-01 0.575 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 3.784825e-01 0.422 0 0
MET activates RAS signaling R-HSA-8851805 4.320074e-01 0.365 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.320074e-01 0.365 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 4.320074e-01 0.365 0 0
Repression of WNT target genes R-HSA-4641265 4.320074e-01 0.365 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 4.320074e-01 0.365 0 0
Polymerase switching R-HSA-69091 4.320074e-01 0.365 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 4.320074e-01 0.365 0 0
Leading Strand Synthesis R-HSA-69109 4.320074e-01 0.365 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 4.320074e-01 0.365 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 4.320074e-01 0.365 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 4.320074e-01 0.365 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 4.320074e-01 0.365 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.162708e-01 0.665 0 0
Signaling by ERBB4 R-HSA-1236394 2.267637e-01 0.644 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.055015e-01 0.687 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 2.643104e-01 0.578 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.597035e-01 0.444 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.597035e-01 0.444 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.597035e-01 0.444 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.868474e-01 0.542 0 0
Centrosome maturation R-HSA-380287 2.374478e-01 0.624 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 4.030026e-01 0.395 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 4.030026e-01 0.395 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 4.030026e-01 0.395 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 4.030026e-01 0.395 0 0
Lagging Strand Synthesis R-HSA-69186 4.272356e-01 0.369 0 0
Termination of translesion DNA synthesis R-HSA-5656169 4.007849e-01 0.397 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.828995e-01 0.548 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.828557e-01 0.738 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 3.769558e-01 0.424 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.211652e-01 0.376 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 3.740958e-01 0.427 0 0
mRNA Splicing R-HSA-72172 2.512074e-01 0.600 0 0
Transcription of the HIV genome R-HSA-167172 2.680316e-01 0.572 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 4.068423e-01 0.391 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 4.272356e-01 0.369 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 4.272356e-01 0.369 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 4.257672e-01 0.371 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.289077e-01 0.483 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.289077e-01 0.483 0 0
Downstream signal transduction R-HSA-186763 2.553758e-01 0.593 0 0
Circadian clock R-HSA-9909396 2.090513e-01 0.680 0 0
DNA Damage Bypass R-HSA-73893 1.587108e-01 0.799 0 0
G0 and Early G1 R-HSA-1538133 2.725842e-01 0.564 0 0
PCP/CE pathway R-HSA-4086400 2.705366e-01 0.568 0 0
Aggrephagy R-HSA-9646399 4.328913e-01 0.364 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.030026e-01 0.395 0 0
Pexophagy R-HSA-9664873 3.352318e-01 0.475 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 3.391086e-01 0.470 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 3.352318e-01 0.475 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.917237e-01 0.717 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 3.034232e-01 0.518 0 0
GAB1 signalosome R-HSA-180292 1.635986e-01 0.786 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 3.040397e-01 0.517 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.342704e-01 0.630 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 2.342704e-01 0.630 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 3.017736e-01 0.520 0 0
PI3K/AKT activation R-HSA-198203 3.352318e-01 0.475 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 2.380320e-01 0.623 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 3.681988e-01 0.434 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 3.681988e-01 0.434 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 4.005032e-01 0.397 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.725842e-01 0.564 0 0
Polo-like kinase mediated events R-HSA-156711 3.537546e-01 0.451 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 4.328913e-01 0.364 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 3.572903e-01 0.447 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.254374e-01 0.488 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 2.792584e-01 0.554 0 0
Killing mechanisms R-HSA-9664420 2.792584e-01 0.554 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 4.320074e-01 0.365 0 0
Synthesis of DNA R-HSA-69239 4.123102e-01 0.385 0 0
IGF1R signaling cascade R-HSA-2428924 3.436943e-01 0.464 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.839124e-01 0.735 0 0
NF-kB is activated and signals survival R-HSA-209560 4.005032e-01 0.397 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 4.320074e-01 0.365 0 0
VLDLR internalisation and degradation R-HSA-8866427 4.320074e-01 0.365 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.612629e-01 0.442 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 4.257672e-01 0.371 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.610683e-01 0.793 0 0
Integration of provirus R-HSA-162592 4.005032e-01 0.397 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 3.597035e-01 0.444 1 1
Degradation of DVL R-HSA-4641258 3.792293e-01 0.421 0 0
G1/S Transition R-HSA-69206 4.113313e-01 0.386 0 0
Neurexins and neuroligins R-HSA-6794361 3.155137e-01 0.501 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.017736e-01 0.520 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 2.186700e-01 0.660 0 0
Formation of the posterior neural plate R-HSA-9832991 3.681988e-01 0.434 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 4.005032e-01 0.397 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 3.537546e-01 0.451 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 3.185546e-01 0.497 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 2.900268e-01 0.538 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 3.784825e-01 0.422 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.211652e-01 0.376 0 0
Stabilization of p53 R-HSA-69541 4.150788e-01 0.382 0 0
PI3K Cascade R-HSA-109704 4.413363e-01 0.355 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 4.351507e-01 0.361 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.484140e-01 0.829 0 0
Myogenesis R-HSA-525793 1.744325e-01 0.758 0 0
Signaling by ROBO receptors R-HSA-376176 3.891999e-01 0.410 0 0
Prolonged ERK activation events R-HSA-169893 2.792584e-01 0.554 0 0
Formation of definitive endoderm R-HSA-9823730 4.030026e-01 0.395 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.927950e-01 0.715 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 2.577729e-01 0.589 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 3.017736e-01 0.520 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.546812e-01 0.594 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.744325e-01 0.758 0 0
Co-inhibition by CTLA4 R-HSA-389513 4.030026e-01 0.395 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.295544e-01 0.482 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 4.184199e-01 0.378 0 0
TCR signaling R-HSA-202403 2.374015e-01 0.625 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.929593e-01 0.715 0 0
Selective autophagy R-HSA-9663891 4.005784e-01 0.397 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 2.007880e-01 0.697 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 3.040397e-01 0.517 0 0
Rap1 signalling R-HSA-392517 3.784825e-01 0.422 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.612629e-01 0.442 0 0
Signaling by SCF-KIT R-HSA-1433557 1.929593e-01 0.715 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.834812e-01 0.736 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 1.813788e-01 0.741 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.546812e-01 0.594 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 3.167426e-01 0.499 0 0
ER to Golgi Anterograde Transport R-HSA-199977 3.503750e-01 0.455 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 2.471257e-01 0.607 0 0
Metabolism of RNA R-HSA-8953854 2.107581e-01 0.676 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 2.471257e-01 0.607 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 2.734794e-01 0.563 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 1.678178e-01 0.775 0 0
Inhibition of PKR R-HSA-169131 1.678178e-01 0.775 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.074886e-01 0.512 0 0
C6 deamination of adenosine R-HSA-75102 3.074886e-01 0.512 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.074886e-01 0.512 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.074886e-01 0.512 0 0
CREB phosphorylation R-HSA-199920 2.007880e-01 0.697 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.610683e-01 0.793 0 0
Type II Na+/Pi cotransporters R-HSA-427589 3.682759e-01 0.434 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 2.066533e-01 0.685 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.066533e-01 0.685 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 2.066533e-01 0.685 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.017736e-01 0.520 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 3.352318e-01 0.475 0 0
Ionotropic activity of kainate receptors R-HSA-451306 3.681988e-01 0.434 0 0
Bicarbonate transporters R-HSA-425381 3.681988e-01 0.434 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.778201e-01 0.556 0 0
Signaling by AXIN mutants R-HSA-4839735 4.005032e-01 0.397 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 3.537546e-01 0.451 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.076591e-01 0.512 0 0
Signalling to ERKs R-HSA-187687 3.433191e-01 0.464 0 0
Orc1 removal from chromatin R-HSA-68949 3.155137e-01 0.501 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 2.530748e-01 0.597 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.644517e-01 0.578 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 2.734794e-01 0.563 0 0
Budding and maturation of HIV virion R-HSA-162588 4.413738e-01 0.355 0 0
Macroautophagy R-HSA-1632852 2.891918e-01 0.539 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.150788e-01 0.382 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.543014e-01 0.812 0 0
Signaling by ALK R-HSA-201556 4.150788e-01 0.382 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 3.642909e-01 0.439 0 0
HDMs demethylate histones R-HSA-3214842 1.595770e-01 0.797 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 2.451515e-01 0.611 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.511624e-01 0.821 0 0
PI Metabolism R-HSA-1483255 3.467415e-01 0.460 0 0
Smooth Muscle Contraction R-HSA-445355 2.030202e-01 0.692 0 0
Early Phase of HIV Life Cycle R-HSA-162594 2.186700e-01 0.660 0 0
Signal attenuation R-HSA-74749 3.352318e-01 0.475 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 3.810114e-01 0.419 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.230051e-01 0.374 0 0
Developmental Biology R-HSA-1266738 1.751616e-01 0.757 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.615580e-01 0.582 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.306405e-01 0.637 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 4.413738e-01 0.355 0 0
Interleukin-15 signaling R-HSA-8983432 4.320074e-01 0.365 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 3.076591e-01 0.512 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.679537e-01 0.775 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 2.304343e-01 0.637 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 3.017736e-01 0.520 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.237307e-01 0.373 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.546812e-01 0.594 0 0
Interleukin-17 signaling R-HSA-448424 1.860438e-01 0.730 0 0
Signaling by LTK R-HSA-9842663 4.320074e-01 0.365 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.407875e-01 0.618 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.200188e-01 0.658 0 0
Generic Transcription Pathway R-HSA-212436 2.391958e-01 0.621 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.744447e-01 0.562 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 4.320074e-01 0.365 0 0
Activation of BH3-only proteins R-HSA-114452 4.211652e-01 0.376 0 0
Signaling by TGFB family members R-HSA-9006936 2.117992e-01 0.674 0 0
G2/M Transition R-HSA-69275 4.236655e-01 0.373 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.792293e-01 0.421 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.184943e-01 0.661 0 0
Inhibition of membrane repair R-HSA-9635644 2.408565e-01 0.618 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.007880e-01 0.697 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.237307e-01 0.373 0 0
2-LTR circle formation R-HSA-164843 3.352318e-01 0.475 0 0
Synthesis of PI R-HSA-1483226 3.681988e-01 0.434 0 0
RET signaling R-HSA-8853659 2.067933e-01 0.684 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.005032e-01 0.397 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 2.900268e-01 0.538 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 4.320074e-01 0.365 0 0
Gap junction trafficking and regulation R-HSA-157858 4.253139e-01 0.371 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 2.374015e-01 0.625 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 4.394438e-01 0.357 0 0
MyD88-independent TLR4 cascade R-HSA-166166 2.374015e-01 0.625 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 2.286416e-01 0.641 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.950267e-01 0.710 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.128050e-01 0.505 0 0
Signaling by NOTCH R-HSA-157118 1.691558e-01 0.772 0 0
Signaling by Interleukins R-HSA-449147 2.049124e-01 0.688 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 3.960769e-01 0.402 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 2.342704e-01 0.630 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 2.680347e-01 0.572 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 2.644457e-01 0.578 0 0
Signal transduction by L1 R-HSA-445144 1.997608e-01 0.699 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.740958e-01 0.427 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.237307e-01 0.373 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 2.507555e-01 0.601 0 0
Synaptic adhesion-like molecules R-HSA-8849932 3.537546e-01 0.451 0 0
RUNX2 regulates bone development R-HSA-8941326 3.612629e-01 0.442 0 0
Viral Infection Pathways R-HSA-9824446 4.121538e-01 0.385 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.637925e-01 0.786 0 0
SARS-CoV-1-host interactions R-HSA-9692914 4.013128e-01 0.397 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.778201e-01 0.556 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.900268e-01 0.538 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.017736e-01 0.520 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.577729e-01 0.589 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.516153e-01 0.599 0 0
Interleukin-2 signaling R-HSA-9020558 3.681988e-01 0.434 0 0
Programmed Cell Death R-HSA-5357801 1.947835e-01 0.710 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.304343e-01 0.637 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 4.272356e-01 0.369 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 3.971800e-01 0.401 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.257672e-01 0.371 0 0
Interleukin-1 family signaling R-HSA-446652 3.044192e-01 0.517 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.146910e-01 0.668 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 3.971800e-01 0.401 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.635986e-01 0.786 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.981034e-01 0.526 0 0
Neurodegenerative Diseases R-HSA-8863678 2.981034e-01 0.526 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.447391e-01 0.463 0 0
Josephin domain DUBs R-HSA-5689877 3.352318e-01 0.475 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 2.792584e-01 0.554 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 3.597035e-01 0.444 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.681988e-01 0.434 0 0
Glycolysis R-HSA-70171 2.266548e-01 0.645 0 0
TNF signaling R-HSA-75893 3.740958e-01 0.427 0 0
SARS-CoV Infections R-HSA-9679506 3.016443e-01 0.521 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 4.272356e-01 0.369 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.572903e-01 0.447 0 0
Glucose metabolism R-HSA-70326 4.276924e-01 0.369 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.487726e-01 0.348 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 4.505850e-01 0.346 0 0
FLT3 Signaling R-HSA-9607240 4.505850e-01 0.346 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 4.511111e-01 0.346 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 4.511111e-01 0.346 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 4.511111e-01 0.346 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 4.511111e-01 0.346 0 0
Assembly Of The HIV Virion R-HSA-175474 4.511111e-01 0.346 0 0
Interleukin-1 signaling R-HSA-9020702 4.529152e-01 0.344 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 4.530769e-01 0.344 0 0
Influenza Infection R-HSA-168255 4.552235e-01 0.342 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 4.572694e-01 0.340 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 4.572715e-01 0.340 0 0
Cytoprotection by HMOX1 R-HSA-9707564 4.574358e-01 0.340 0 0
Signaling by PDGF R-HSA-186797 4.624512e-01 0.335 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.626031e-01 0.335 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 4.626031e-01 0.335 0 0
Interleukin-6 signaling R-HSA-1059683 4.626031e-01 0.335 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 4.626031e-01 0.335 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 4.626031e-01 0.335 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 4.681295e-01 0.330 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 4.681295e-01 0.330 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.681295e-01 0.330 0 0
Parasite infection R-HSA-9664407 4.741884e-01 0.324 0 0
Leishmania phagocytosis R-HSA-9664417 4.741884e-01 0.324 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 4.741884e-01 0.324 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 4.743204e-01 0.324 0 0
FGFR1c and Klotho ligand binding and activation R-HSA-190374 4.743204e-01 0.324 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 4.743204e-01 0.324 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 4.743204e-01 0.324 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 4.743204e-01 0.324 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 4.743204e-01 0.324 0 0
PTK6 Activates STAT3 R-HSA-8849474 4.743204e-01 0.324 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 4.743204e-01 0.324 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 4.743204e-01 0.324 0 0
Activation of AKT2 R-HSA-165158 4.743204e-01 0.324 0 0
Reelin signalling pathway R-HSA-8866376 4.743204e-01 0.324 0 0
Muscarinic acetylcholine receptors R-HSA-390648 4.743204e-01 0.324 0 0
Inositol transporters R-HSA-429593 4.743204e-01 0.324 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 4.743204e-01 0.324 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.743204e-01 0.324 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 4.743204e-01 0.324 0 0
FGFR2 alternative splicing R-HSA-6803529 4.745672e-01 0.324 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 4.745672e-01 0.324 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 4.745672e-01 0.324 0 0
Signaling by KIT in disease R-HSA-9669938 4.745672e-01 0.324 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 4.838977e-01 0.315 0 0
MHC class II antigen presentation R-HSA-2132295 4.906787e-01 0.309 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.921870e-01 0.308 0 0
NRIF signals cell death from the nucleus R-HSA-205043 4.922070e-01 0.308 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.922070e-01 0.308 0 0
Retrograde neurotrophin signalling R-HSA-177504 4.922070e-01 0.308 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 4.922070e-01 0.308 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 4.922070e-01 0.308 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 4.935680e-01 0.307 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 4.975504e-01 0.303 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 4.975504e-01 0.303 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 4.975504e-01 0.303 0 0
Syndecan interactions R-HSA-3000170 4.975504e-01 0.303 0 0
Growth hormone receptor signaling R-HSA-982772 4.975504e-01 0.303 0 0
Translation initiation complex formation R-HSA-72649 5.043114e-01 0.297 0 0
Cellular response to hypoxia R-HSA-1234174 5.056887e-01 0.296 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 5.059738e-01 0.296 0 0
UCH proteinases R-HSA-5689603 5.068828e-01 0.295 0 0
Interleukin-12 signaling R-HSA-9020591 5.068828e-01 0.295 0 0
XBP1(S) activates chaperone genes R-HSA-381038 5.079458e-01 0.294 0 0
Cyclin D associated events in G1 R-HSA-69231 5.195941e-01 0.284 0 0
G1 Phase R-HSA-69236 5.195941e-01 0.284 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 5.196729e-01 0.284 0 0
NOD1/2 Signaling Pathway R-HSA-168638 5.196729e-01 0.284 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 5.196729e-01 0.284 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 5.200851e-01 0.284 0 0
Interleukin-12 family signaling R-HSA-447115 5.203631e-01 0.284 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.204718e-01 0.284 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.204718e-01 0.284 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.204718e-01 0.284 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.204718e-01 0.284 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 5.204718e-01 0.284 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.204718e-01 0.284 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 5.204718e-01 0.284 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 5.204718e-01 0.284 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.204718e-01 0.284 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.204718e-01 0.284 0 0
PKB-mediated events R-HSA-109703 5.204718e-01 0.284 0 0
PDE3B signalling R-HSA-165160 5.204718e-01 0.284 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.204718e-01 0.284 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 5.204718e-01 0.284 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 5.204718e-01 0.284 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.206682e-01 0.283 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 5.207575e-01 0.283 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 5.207575e-01 0.283 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 5.207575e-01 0.283 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.207575e-01 0.283 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 5.207575e-01 0.283 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 5.207575e-01 0.283 0 0
p38MAPK events R-HSA-171007 5.207575e-01 0.283 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.207575e-01 0.283 0 0
Biotin transport and metabolism R-HSA-196780 5.207575e-01 0.283 0 0
Protein methylation R-HSA-8876725 5.207575e-01 0.283 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 5.207575e-01 0.283 0 0
Formation of the anterior neural plate R-HSA-9823739 5.207575e-01 0.283 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 5.207575e-01 0.283 0 0
SLC transporter disorders R-HSA-5619102 5.320007e-01 0.274 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 5.348431e-01 0.272 0 0
Signaling by FGFR1 R-HSA-5654736 5.348431e-01 0.272 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 5.362782e-01 0.271 0 0
DAG and IP3 signaling R-HSA-1489509 5.362782e-01 0.271 0 0
Regulation of Apoptosis R-HSA-169911 5.384415e-01 0.269 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 5.419209e-01 0.266 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 5.476982e-01 0.261 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.482114e-01 0.261 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 5.482114e-01 0.261 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 5.482114e-01 0.261 0 0
Negative regulation of FLT3 R-HSA-9706369 5.482114e-01 0.261 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 5.482114e-01 0.261 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 5.482114e-01 0.261 0 0
IRS-mediated signalling R-HSA-112399 5.498073e-01 0.260 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 5.526917e-01 0.258 0 0
HSF1 activation R-HSA-3371511 5.568311e-01 0.254 0 0
FLT3 signaling in disease R-HSA-9682385 5.568311e-01 0.254 0 0
Calmodulin induced events R-HSA-111933 5.568311e-01 0.254 0 0
CaM pathway R-HSA-111997 5.568311e-01 0.254 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 5.625738e-01 0.250 0 0
Signaling by LTK in cancer R-HSA-9842640 5.625738e-01 0.250 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.625738e-01 0.250 0 0
STAT5 Activation R-HSA-9645135 5.625738e-01 0.250 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 5.625738e-01 0.250 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 5.625738e-01 0.250 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 5.625738e-01 0.250 0 0
MET Receptor Activation R-HSA-6806942 5.625738e-01 0.250 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 5.625738e-01 0.250 0 0
Nef and signal transduction R-HSA-164944 5.625738e-01 0.250 0 0
Signaling by EGFR in Cancer R-HSA-1643713 5.632371e-01 0.249 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 5.632371e-01 0.249 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 5.632371e-01 0.249 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 5.632371e-01 0.249 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 5.632371e-01 0.249 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 5.632371e-01 0.249 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 5.645499e-01 0.248 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 5.655295e-01 0.248 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 5.688162e-01 0.245 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 5.745413e-01 0.241 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 5.745413e-01 0.241 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.745413e-01 0.241 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 5.745413e-01 0.241 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 5.745413e-01 0.241 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 5.745413e-01 0.241 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.748194e-01 0.240 0 0
Cytokine Signaling in Immune system R-HSA-1280215 5.791468e-01 0.237 0 0
IRE1alpha activates chaperones R-HSA-381070 5.806875e-01 0.236 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 5.823264e-01 0.235 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 5.838715e-01 0.234 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.839373e-01 0.234 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 5.839373e-01 0.234 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 5.839373e-01 0.234 0 0
Insulin processing R-HSA-264876 5.839373e-01 0.234 0 0
SARS-CoV-2 Infection R-HSA-9694516 5.853001e-01 0.233 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 5.875438e-01 0.231 0 0
Adipogenesis R-HSA-9843745 5.915359e-01 0.228 0 0
Kinesins R-HSA-983189 5.933169e-01 0.227 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 5.965591e-01 0.224 0 0
Adaptive Immune System R-HSA-1280218 5.976128e-01 0.224 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 5.997328e-01 0.222 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 5.997328e-01 0.222 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 5.997328e-01 0.222 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 5.997328e-01 0.222 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 6.001347e-01 0.222 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 6.001347e-01 0.222 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.009816e-01 0.221 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.009816e-01 0.221 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.009816e-01 0.221 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 6.009816e-01 0.221 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.009816e-01 0.221 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.009816e-01 0.221 0 0
PTK6 Expression R-HSA-8849473 6.009816e-01 0.221 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.009816e-01 0.221 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.009816e-01 0.221 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 6.009816e-01 0.221 0 0
VLDL clearance R-HSA-8964046 6.009816e-01 0.221 0 0
Regulation of PTEN localization R-HSA-8948747 6.009816e-01 0.221 0 0
Netrin mediated repulsion signals R-HSA-418886 6.009816e-01 0.221 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 6.009816e-01 0.221 0 0
CHL1 interactions R-HSA-447041 6.009816e-01 0.221 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.009816e-01 0.221 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.009816e-01 0.221 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 6.040010e-01 0.219 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 6.040010e-01 0.219 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 6.040010e-01 0.219 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 6.071245e-01 0.217 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 6.095179e-01 0.215 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 6.095179e-01 0.215 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 6.097118e-01 0.215 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 6.106782e-01 0.214 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 6.234131e-01 0.205 0 0
mRNA Capping R-HSA-72086 6.234131e-01 0.205 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 6.234131e-01 0.205 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 6.234131e-01 0.205 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.237828e-01 0.205 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 6.237828e-01 0.205 0 0
FGFR1 ligand binding and activation R-HSA-190242 6.237828e-01 0.205 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.237828e-01 0.205 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 6.261985e-01 0.203 0 0
Attenuation phase R-HSA-3371568 6.261985e-01 0.203 0 0
HIV Transcription Elongation R-HSA-167169 6.261985e-01 0.203 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 6.261985e-01 0.203 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 6.261985e-01 0.203 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 6.261985e-01 0.203 0 0
Interleukin-2 family signaling R-HSA-451927 6.261985e-01 0.203 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 6.261985e-01 0.203 0 0
Signaling by NOTCH4 R-HSA-9013694 6.266549e-01 0.203 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 6.293799e-01 0.201 0 0
Ion channel transport R-HSA-983712 6.317380e-01 0.199 0 0
FGFR1b ligand binding and activation R-HSA-190370 6.360191e-01 0.197 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 6.360191e-01 0.197 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 6.360191e-01 0.197 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 6.360191e-01 0.197 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 6.360191e-01 0.197 0 0
Interleukin-23 signaling R-HSA-9020933 6.360191e-01 0.197 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 6.360191e-01 0.197 0 0
Interleukin-9 signaling R-HSA-8985947 6.360191e-01 0.197 0 0
Alpha-defensins R-HSA-1462054 6.360191e-01 0.197 0 0
Sodium/Proton exchangers R-HSA-425986 6.360191e-01 0.197 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 6.360191e-01 0.197 0 0
Adrenoceptors R-HSA-390696 6.360191e-01 0.197 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 6.360191e-01 0.197 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 6.360191e-01 0.197 0 0
Cellular response to chemical stress R-HSA-9711123 6.389262e-01 0.195 0 0
DAP12 signaling R-HSA-2424491 6.421630e-01 0.192 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 6.421630e-01 0.192 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 6.421630e-01 0.192 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 6.424181e-01 0.192 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 6.424181e-01 0.192 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 6.424181e-01 0.192 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 6.445965e-01 0.191 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 6.445965e-01 0.191 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.466976e-01 0.189 0 0
Germ layer formation at gastrulation R-HSA-9754189 6.466976e-01 0.189 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.466976e-01 0.189 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.466976e-01 0.189 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 6.466976e-01 0.189 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 6.466976e-01 0.189 0 0
The NLRP3 inflammasome R-HSA-844456 6.466976e-01 0.189 0 0
STING mediated induction of host immune responses R-HSA-1834941 6.466976e-01 0.189 0 0
Toll-like Receptor Cascades R-HSA-168898 6.473450e-01 0.189 0 0
Insulin receptor signalling cascade R-HSA-74751 6.476712e-01 0.189 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 6.476712e-01 0.189 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 6.481411e-01 0.188 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 6.481411e-01 0.188 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 6.565906e-01 0.183 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.581683e-01 0.182 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 6.581683e-01 0.182 0 0
HIV Transcription Initiation R-HSA-167161 6.581683e-01 0.182 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.581683e-01 0.182 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 6.581683e-01 0.182 0 0
Degradation of CRY and PER proteins R-HSA-9932298 6.581683e-01 0.182 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.581683e-01 0.182 0 0
Amino acids regulate mTORC1 R-HSA-9639288 6.587075e-01 0.181 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 6.587075e-01 0.181 0 0
Regulation of PTEN stability and activity R-HSA-8948751 6.587075e-01 0.181 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 6.602446e-01 0.180 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 6.602446e-01 0.180 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 6.679819e-01 0.175 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 6.679819e-01 0.175 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 6.679819e-01 0.175 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 6.679819e-01 0.175 0 0
Interleukin-21 signaling R-HSA-9020958 6.679819e-01 0.175 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 6.679819e-01 0.175 0 0
mRNA Editing R-HSA-75072 6.679819e-01 0.175 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 6.679819e-01 0.175 0 0
Regulation of signaling by NODAL R-HSA-1433617 6.679819e-01 0.175 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 6.679819e-01 0.175 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 6.679819e-01 0.175 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 6.679819e-01 0.175 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 6.679819e-01 0.175 0 0
Protein hydroxylation R-HSA-9629569 6.684911e-01 0.175 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 6.684911e-01 0.175 0 0
Signaling by FGFR R-HSA-190236 6.692122e-01 0.174 0 0
Gastrulation R-HSA-9758941 6.694866e-01 0.174 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 6.724521e-01 0.172 0 0
Ca-dependent events R-HSA-111996 6.734432e-01 0.172 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 6.734432e-01 0.172 0 0
Signaling by WNT in cancer R-HSA-4791275 6.776554e-01 0.169 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 6.776554e-01 0.169 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 6.776554e-01 0.169 0 0
Platelet activation, signaling and aggregation R-HSA-76002 6.779238e-01 0.169 0 0
FOXO-mediated transcription R-HSA-9614085 6.794623e-01 0.168 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 6.858256e-01 0.164 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 6.858256e-01 0.164 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 6.882389e-01 0.162 0 0
Signaling by FGFR4 R-HSA-5654743 6.882389e-01 0.162 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 6.891835e-01 0.162 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.891835e-01 0.162 0 0
Signalling to RAS R-HSA-167044 6.891835e-01 0.162 0 0
ERK/MAPK targets R-HSA-198753 6.891835e-01 0.162 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.891835e-01 0.162 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 6.943963e-01 0.158 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 6.943963e-01 0.158 0 0
G-protein beta:gamma signalling R-HSA-397795 6.943963e-01 0.158 0 0
Cardiac conduction R-HSA-5576891 6.967467e-01 0.157 0 0
DNA replication initiation R-HSA-68952 6.971396e-01 0.157 0 0
Folding of actin by CCT/TriC R-HSA-390450 6.971396e-01 0.157 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 6.971396e-01 0.157 0 0
Binding and entry of HIV virion R-HSA-173107 6.971396e-01 0.157 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 6.971396e-01 0.157 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 6.971396e-01 0.157 0 0
Arachidonate production from DAG R-HSA-426048 6.971396e-01 0.157 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 6.971396e-01 0.157 0 0
Interleukin-27 signaling R-HSA-9020956 6.971396e-01 0.157 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 6.971396e-01 0.157 0 0
Receptor Mediated Mitophagy R-HSA-8934903 6.971396e-01 0.157 0 0
Signaling by FGFR2 R-HSA-5654738 6.972768e-01 0.157 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 6.973721e-01 0.157 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 6.988247e-01 0.156 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 6.988247e-01 0.156 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 6.988247e-01 0.156 0 0
Gap junction trafficking R-HSA-190828 7.025534e-01 0.153 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.081530e-01 0.150 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 7.088000e-01 0.149 0 0
Serine metabolism R-HSA-977347 7.088000e-01 0.149 0 0
Resolution of D-Loop Structures R-HSA-5693537 7.104712e-01 0.148 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 7.104712e-01 0.148 0 0
Vpu mediated degradation of CD4 R-HSA-180534 7.104712e-01 0.148 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.104712e-01 0.148 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.163867e-01 0.145 0 0
Signaling by FGFR3 R-HSA-5654741 7.163867e-01 0.145 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 7.225575e-01 0.141 0 0
Dual incision in TC-NER R-HSA-6782135 7.236922e-01 0.140 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 7.237383e-01 0.140 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.237383e-01 0.140 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 7.237383e-01 0.140 0 0
LGI-ADAM interactions R-HSA-5682910 7.237383e-01 0.140 0 0
vRNA Synthesis R-HSA-192814 7.237383e-01 0.140 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.237383e-01 0.140 0 0
Transport of RCbl within the body R-HSA-9758890 7.237383e-01 0.140 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.237383e-01 0.140 0 0
Cilium Assembly R-HSA-5617833 7.244221e-01 0.140 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 7.258869e-01 0.139 0 0
Dual Incision in GG-NER R-HSA-5696400 7.258869e-01 0.139 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 7.258869e-01 0.139 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 7.258869e-01 0.139 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 7.258869e-01 0.139 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 7.258869e-01 0.139 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 7.273700e-01 0.138 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 7.273700e-01 0.138 0 0
LDL clearance R-HSA-8964038 7.273700e-01 0.138 0 0
Cellular hexose transport R-HSA-189200 7.273700e-01 0.138 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 7.273700e-01 0.138 0 0
Response of endothelial cells to shear stress R-HSA-9860931 7.277411e-01 0.138 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 7.297404e-01 0.137 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 7.297404e-01 0.137 0 0
Regulation of TNFR1 signaling R-HSA-5357905 7.297404e-01 0.137 0 0
Hedgehog 'on' state R-HSA-5632684 7.314252e-01 0.136 0 0
Extension of Telomeres R-HSA-180786 7.355599e-01 0.133 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.406522e-01 0.130 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 7.406522e-01 0.130 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 7.406522e-01 0.130 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 7.406522e-01 0.130 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 7.426174e-01 0.129 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 7.449259e-01 0.128 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 7.449259e-01 0.128 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 7.449259e-01 0.128 0 0
Carnitine shuttle R-HSA-200425 7.449259e-01 0.128 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 7.480024e-01 0.126 0 0
tRNA processing R-HSA-72306 7.484337e-01 0.126 0 0
Ca2+ pathway R-HSA-4086398 7.525709e-01 0.123 0 0
Platelet degranulation R-HSA-114608 7.530669e-01 0.123 0 0
G1/S-Specific Transcription R-HSA-69205 7.547781e-01 0.122 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 7.547781e-01 0.122 0 0
RNA Polymerase III Transcription R-HSA-74158 7.547781e-01 0.122 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 7.547781e-01 0.122 0 0
GPVI-mediated activation cascade R-HSA-114604 7.547781e-01 0.122 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 7.547781e-01 0.122 0 0
Co-stimulation by CD28 R-HSA-389356 7.550222e-01 0.122 0 0
PLC beta mediated events R-HSA-112043 7.581688e-01 0.120 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 7.581688e-01 0.120 0 0
Formation of paraxial mesoderm R-HSA-9793380 7.581688e-01 0.120 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 7.615027e-01 0.118 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 7.615027e-01 0.118 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 7.615027e-01 0.118 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.615027e-01 0.118 0 0
Interleukin-6 family signaling R-HSA-6783589 7.615027e-01 0.118 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 7.682772e-01 0.114 0 0
Degradation of AXIN R-HSA-4641257 7.682772e-01 0.114 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 7.682772e-01 0.114 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 7.689150e-01 0.114 0 0
NCAM signaling for neurite out-growth R-HSA-375165 7.689150e-01 0.114 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 7.701367e-01 0.113 0 0
Maple Syrup Urine Disease R-HSA-9865114 7.701367e-01 0.113 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.701367e-01 0.113 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 7.701367e-01 0.113 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 7.701367e-01 0.113 0 0
Regulation of IFNG signaling R-HSA-877312 7.701367e-01 0.113 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 7.701367e-01 0.113 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 7.701367e-01 0.113 0 0
Disorders of Nervous System Development R-HSA-9697154 7.701367e-01 0.113 0 0
Pervasive developmental disorders R-HSA-9005895 7.701367e-01 0.113 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 7.701367e-01 0.113 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 7.701367e-01 0.113 0 0
OAS antiviral response R-HSA-8983711 7.701367e-01 0.113 0 0
Interleukin-35 Signalling R-HSA-8984722 7.701367e-01 0.113 0 0
Chaperonin-mediated protein folding R-HSA-390466 7.768753e-01 0.110 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.771367e-01 0.110 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.771367e-01 0.110 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 7.792938e-01 0.108 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 7.811636e-01 0.107 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 7.894648e-01 0.103 0 0
Formation of axial mesoderm R-HSA-9796292 7.903280e-01 0.102 0 0
FGFR1c ligand binding and activation R-HSA-190373 7.903280e-01 0.102 0 0
Frs2-mediated activation R-HSA-170968 7.903280e-01 0.102 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 7.903280e-01 0.102 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 7.903280e-01 0.102 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 7.903280e-01 0.102 0 0
Processing of SMDT1 R-HSA-8949664 7.903280e-01 0.102 0 0
Maturation of nucleoprotein R-HSA-9683610 7.903280e-01 0.102 0 0
MET activates PTK2 signaling R-HSA-8874081 7.918658e-01 0.101 0 0
Metalloprotease DUBs R-HSA-5689901 7.918658e-01 0.101 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 7.918658e-01 0.101 0 0
Sphingolipid catabolism R-HSA-9845614 7.918658e-01 0.101 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 7.918658e-01 0.101 0 0
Plasma lipoprotein clearance R-HSA-8964043 7.934527e-01 0.100 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 7.934527e-01 0.100 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.934527e-01 0.100 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 7.993958e-01 0.097 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.000470e-01 0.097 0 0
Downstream TCR signaling R-HSA-202424 8.023817e-01 0.096 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.049291e-01 0.094 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.057282e-01 0.094 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 8.057282e-01 0.094 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.057282e-01 0.094 0 0
Sensory processing of sound R-HSA-9659379 8.086477e-01 0.092 0 0
Removal of the Flap Intermediate R-HSA-69166 8.087468e-01 0.092 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 8.087468e-01 0.092 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 8.087468e-01 0.092 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.087468e-01 0.092 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 8.087468e-01 0.092 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.087468e-01 0.092 0 0
Signaling by FGFR4 in disease R-HSA-5655291 8.087468e-01 0.092 0 0
Physiological factors R-HSA-5578768 8.087468e-01 0.092 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.087468e-01 0.092 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 8.101947e-01 0.091 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 8.163048e-01 0.088 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.163048e-01 0.088 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 8.163048e-01 0.088 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.163048e-01 0.088 0 0
G-protein mediated events R-HSA-112040 8.172329e-01 0.088 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.187624e-01 0.087 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.187624e-01 0.087 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 8.187624e-01 0.087 0 0
Inflammasomes R-HSA-622312 8.187624e-01 0.087 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.190118e-01 0.087 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 8.199176e-01 0.086 0 0
Interferon Signaling R-HSA-913531 8.236396e-01 0.084 0 0
Erythropoietin activates RAS R-HSA-9027284 8.255486e-01 0.083 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.255486e-01 0.083 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 8.255486e-01 0.083 0 0
Translesion synthesis by REV1 R-HSA-110312 8.255486e-01 0.083 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.255486e-01 0.083 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 8.255486e-01 0.083 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.255486e-01 0.083 0 0
Other semaphorin interactions R-HSA-416700 8.255486e-01 0.083 0 0
Signaling by Insulin receptor R-HSA-74752 8.255987e-01 0.083 0 0
Protein folding R-HSA-391251 8.255987e-01 0.083 0 0
Signaling by NOTCH3 R-HSA-9012852 8.292260e-01 0.081 0 0
Signaling by Erythropoietin R-HSA-9006335 8.310070e-01 0.080 0 0
Platelet calcium homeostasis R-HSA-418360 8.310070e-01 0.080 0 0
Regulation of gene expression in beta cells R-HSA-210745 8.310070e-01 0.080 0 0
Translesion synthesis by POLI R-HSA-5656121 8.408752e-01 0.075 0 0
Phosphorylation of the APC/C R-HSA-176412 8.408752e-01 0.075 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 8.408752e-01 0.075 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.408752e-01 0.075 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.408752e-01 0.075 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.408752e-01 0.075 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 8.408752e-01 0.075 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 8.408752e-01 0.075 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 8.408752e-01 0.075 0 0
Differentiation of T cells R-HSA-9945266 8.408752e-01 0.075 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.408752e-01 0.075 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.425000e-01 0.074 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.425000e-01 0.074 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 8.465322e-01 0.072 0 0
Disorders of transmembrane transporters R-HSA-5619115 8.475965e-01 0.072 0 0
Mitochondrial biogenesis R-HSA-1592230 8.481148e-01 0.072 0 0
Regulation of mitotic cell cycle R-HSA-453276 8.497482e-01 0.071 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 8.497482e-01 0.071 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.497482e-01 0.071 0 0
Organelle biogenesis and maintenance R-HSA-1852241 8.507341e-01 0.070 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 8.548561e-01 0.068 0 0
Translesion synthesis by POLK R-HSA-5655862 8.548561e-01 0.068 0 0
Phase 2 - plateau phase R-HSA-5576893 8.548561e-01 0.068 0 0
Fibronectin matrix formation R-HSA-1566977 8.548561e-01 0.068 0 0
Heme assimilation R-HSA-9927020 8.548561e-01 0.068 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 8.548561e-01 0.068 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 8.548561e-01 0.068 0 0
Disorders of Developmental Biology R-HSA-9675151 8.548561e-01 0.068 0 0
Coenzyme A biosynthesis R-HSA-196783 8.548561e-01 0.068 0 0
Proteasome assembly R-HSA-9907900 8.556012e-01 0.068 0 0
DAP12 interactions R-HSA-2172127 8.556012e-01 0.068 0 0
Surfactant metabolism R-HSA-5683826 8.556012e-01 0.068 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 8.556012e-01 0.068 0 0
Transmission across Chemical Synapses R-HSA-112315 8.616621e-01 0.065 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.625357e-01 0.064 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.633807e-01 0.064 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 8.641978e-01 0.063 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 8.641978e-01 0.063 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.641978e-01 0.063 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.641978e-01 0.063 0 0
Somitogenesis R-HSA-9824272 8.641978e-01 0.063 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.676094e-01 0.062 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 8.676094e-01 0.062 0 0
Glycogen storage diseases R-HSA-3229121 8.676094e-01 0.062 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.676094e-01 0.062 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 8.676094e-01 0.062 0 0
Uptake and function of anthrax toxins R-HSA-5210891 8.676094e-01 0.062 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.699394e-01 0.061 1 1
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.723407e-01 0.059 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.723407e-01 0.059 0 0
Diseases of DNA repair R-HSA-9675135 8.723407e-01 0.059 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 8.728408e-01 0.059 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 8.792428e-01 0.056 0 0
Presynaptic function of Kainate receptors R-HSA-500657 8.792428e-01 0.056 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 8.792428e-01 0.056 0 0
Platelet sensitization by LDL R-HSA-432142 8.792428e-01 0.056 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 8.792428e-01 0.056 0 0
Mismatch Repair R-HSA-5358508 8.792428e-01 0.056 0 0
FCERI mediated MAPK activation R-HSA-2871796 8.811424e-01 0.055 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.816941e-01 0.055 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.816941e-01 0.055 0 0
Hedgehog 'off' state R-HSA-5610787 8.825226e-01 0.054 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 8.837205e-01 0.054 0 0
Leishmania infection R-HSA-9658195 8.839708e-01 0.054 0 0
Parasitic Infection Pathways R-HSA-9824443 8.839708e-01 0.054 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 8.898546e-01 0.051 0 0
Translesion Synthesis by POLH R-HSA-110320 8.898546e-01 0.051 0 0
Pyrimidine biosynthesis R-HSA-500753 8.898546e-01 0.051 0 0
Other interleukin signaling R-HSA-449836 8.898546e-01 0.051 0 0
Specification of the neural plate border R-HSA-9834899 8.898546e-01 0.051 0 0
Maturation of nucleoprotein R-HSA-9694631 8.898546e-01 0.051 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 8.898546e-01 0.051 0 0
Mitophagy R-HSA-5205647 8.899741e-01 0.051 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.901216e-01 0.051 0 0
Neurotransmitter release cycle R-HSA-112310 8.905625e-01 0.050 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 8.942312e-01 0.049 0 0
Interleukin-10 signaling R-HSA-6783783 8.950513e-01 0.048 0 0
Integrin cell surface interactions R-HSA-216083 8.950513e-01 0.048 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 8.995344e-01 0.046 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 8.995344e-01 0.046 0 0
Glycogen synthesis R-HSA-3322077 8.995344e-01 0.046 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 8.995344e-01 0.046 0 0
Signaling by NODAL R-HSA-1181150 8.995344e-01 0.046 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.003030e-01 0.046 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.004502e-01 0.046 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.007420e-01 0.045 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.028100e-01 0.044 0 0
Neutrophil degranulation R-HSA-6798695 9.041859e-01 0.044 0 0
Glycosphingolipid transport R-HSA-9845576 9.049424e-01 0.043 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.049424e-01 0.043 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.049424e-01 0.043 0 0
PKR-mediated signaling R-HSA-9833482 9.056061e-01 0.043 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.063297e-01 0.043 0 0
RSV-host interactions R-HSA-9833110 9.068165e-01 0.042 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.068889e-01 0.042 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.083641e-01 0.042 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 9.083641e-01 0.042 0 0
Basigin interactions R-HSA-210991 9.083641e-01 0.042 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.083641e-01 0.042 0 0
FCGR activation R-HSA-2029481 9.102328e-01 0.041 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.126890e-01 0.040 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 9.127352e-01 0.040 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.164182e-01 0.038 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.164182e-01 0.038 0 0
Glutathione synthesis and recycling R-HSA-174403 9.164182e-01 0.038 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.164182e-01 0.038 0 0
Elastic fibre formation R-HSA-1566948 9.179894e-01 0.037 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 9.230289e-01 0.035 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.237649e-01 0.034 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.237649e-01 0.034 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.237649e-01 0.034 0 0
Notch-HLH transcription pathway R-HSA-350054 9.237649e-01 0.034 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.237649e-01 0.034 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.237649e-01 0.034 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.261585e-01 0.033 0 0
COPII-mediated vesicle transport R-HSA-204005 9.268721e-01 0.033 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 9.268721e-01 0.033 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.271389e-01 0.033 0 0
G alpha (z) signalling events R-HSA-418597 9.281697e-01 0.032 0 0
Paracetamol ADME R-HSA-9753281 9.281697e-01 0.032 0 0
Diseases of Immune System R-HSA-5260271 9.293378e-01 0.032 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.293378e-01 0.032 0 0
Glycogen metabolism R-HSA-8982491 9.293378e-01 0.032 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.293378e-01 0.032 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.304662e-01 0.031 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 9.304662e-01 0.031 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.304662e-01 0.031 0 0
Interleukin-20 family signaling R-HSA-8854691 9.304662e-01 0.031 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.304662e-01 0.031 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.304662e-01 0.031 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.304662e-01 0.031 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.312771e-01 0.031 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.318987e-01 0.031 0 0
Peptide ligand-binding receptors R-HSA-375276 9.360550e-01 0.029 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.365788e-01 0.028 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.365788e-01 0.028 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 9.365788e-01 0.028 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.365788e-01 0.028 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.365788e-01 0.028 0 0
Formation of the cornified envelope R-HSA-6809371 9.368984e-01 0.028 0 0
Dectin-2 family R-HSA-5621480 9.370442e-01 0.028 0 0
Intra-Golgi traffic R-HSA-6811438 9.391899e-01 0.027 0 0
ABC-family proteins mediated transport R-HSA-382556 9.405529e-01 0.027 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.421544e-01 0.026 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.421544e-01 0.026 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.421544e-01 0.026 0 0
Laminin interactions R-HSA-3000157 9.421544e-01 0.026 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.421544e-01 0.026 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.436126e-01 0.025 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 9.436167e-01 0.025 0 0
Regulation of beta-cell development R-HSA-186712 9.448956e-01 0.025 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.459037e-01 0.024 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.472401e-01 0.024 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 9.472401e-01 0.024 0 0
TRP channels R-HSA-3295583 9.472401e-01 0.024 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.472401e-01 0.024 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.472401e-01 0.024 0 0
tRNA Aminoacylation R-HSA-379724 9.484707e-01 0.023 0 0
Metabolism of polyamines R-HSA-351202 9.484707e-01 0.023 0 0
Signaling by NOTCH1 R-HSA-1980143 9.491184e-01 0.023 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.508023e-01 0.022 0 0
RMTs methylate histone arginines R-HSA-3214858 9.515559e-01 0.022 0 0
Amine ligand-binding receptors R-HSA-375280 9.515559e-01 0.022 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.515559e-01 0.022 0 0
Cristae formation R-HSA-8949613 9.518790e-01 0.021 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 9.518790e-01 0.021 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.518790e-01 0.021 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.518790e-01 0.021 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.518790e-01 0.021 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.518790e-01 0.021 0 0
Opioid Signalling R-HSA-111885 9.519779e-01 0.021 0 0
Cap-dependent Translation Initiation R-HSA-72737 9.532553e-01 0.021 0 0
Eukaryotic Translation Initiation R-HSA-72613 9.532553e-01 0.021 0 0
PPARA activates gene expression R-HSA-1989781 9.551140e-01 0.020 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.551152e-01 0.020 0 0
Insulin receptor recycling R-HSA-77387 9.561102e-01 0.019 0 0
Telomere Extension By Telomerase R-HSA-171319 9.561102e-01 0.019 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.561102e-01 0.019 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.561102e-01 0.019 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.567275e-01 0.019 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.579406e-01 0.019 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.584233e-01 0.018 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.591672e-01 0.018 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.599696e-01 0.018 0 0
DARPP-32 events R-HSA-180024 9.599696e-01 0.018 0 0
Cellular response to starvation R-HSA-9711097 9.608675e-01 0.017 0 0
Synthesis of PC R-HSA-1483191 9.614970e-01 0.017 0 0
Neuronal System R-HSA-112316 9.628048e-01 0.016 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 9.634569e-01 0.016 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.634899e-01 0.016 0 0
Neurotransmitter clearance R-HSA-112311 9.634899e-01 0.016 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 9.636726e-01 0.016 0 0
GPER1 signaling R-HSA-9634597 9.643519e-01 0.016 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.667008e-01 0.015 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.667008e-01 0.015 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.667008e-01 0.015 0 0
Cargo concentration in the ER R-HSA-5694530 9.667008e-01 0.015 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.670027e-01 0.015 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.671393e-01 0.015 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.677165e-01 0.014 0 0
Immune System R-HSA-168256 9.696333e-01 0.013 0 0
Post-translational protein modification R-HSA-597592 9.702229e-01 0.013 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.713409e-01 0.013 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.717462e-01 0.012 0 0
Complex IV assembly R-HSA-9864848 9.717462e-01 0.012 0 0
The phototransduction cascade R-HSA-2514856 9.717462e-01 0.012 0 0
Recycling of bile acids and salts R-HSA-159418 9.723007e-01 0.012 0 0
Cardiogenesis R-HSA-9733709 9.723007e-01 0.012 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.734926e-01 0.012 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.738227e-01 0.012 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.738642e-01 0.012 0 0
Infectious disease R-HSA-5663205 9.744382e-01 0.011 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.747371e-01 0.011 0 0
Heme degradation R-HSA-189483 9.747371e-01 0.011 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.769594e-01 0.010 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.769594e-01 0.010 0 0
Signaling by NOTCH2 R-HSA-1980145 9.769594e-01 0.010 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.769594e-01 0.010 0 0
Hyaluronan metabolism R-HSA-2142845 9.769594e-01 0.010 0 0
Signal amplification R-HSA-392518 9.769594e-01 0.010 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.769594e-01 0.010 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.774678e-01 0.010 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.789863e-01 0.009 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.789863e-01 0.009 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.789863e-01 0.009 0 0
PERK regulates gene expression R-HSA-381042 9.789863e-01 0.009 0 0
ER-Phagosome pathway R-HSA-1236974 9.790606e-01 0.009 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.800726e-01 0.009 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.809009e-01 0.008 0 0
NCAM1 interactions R-HSA-419037 9.825212e-01 0.008 0 0
Collagen chain trimerization R-HSA-8948216 9.825212e-01 0.008 0 0
Metabolism of folate and pterines R-HSA-196757 9.825212e-01 0.008 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.840591e-01 0.007 0 0
Peroxisomal protein import R-HSA-9033241 9.849341e-01 0.007 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.849341e-01 0.007 0 0
Cholesterol biosynthesis R-HSA-191273 9.852992e-01 0.006 0 0
ABC transporter disorders R-HSA-5619084 9.852992e-01 0.006 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.853755e-01 0.006 0 0
Stimuli-sensing channels R-HSA-2672351 9.853755e-01 0.006 0 0
RAS processing R-HSA-9648002 9.854618e-01 0.006 0 0
Pentose phosphate pathway R-HSA-71336 9.854618e-01 0.006 0 0
Collagen formation R-HSA-1474290 9.859046e-01 0.006 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 9.860842e-01 0.006 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 9.860842e-01 0.006 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 9.860842e-01 0.006 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 9.860842e-01 0.006 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 9.860842e-01 0.006 0 0
Neddylation R-HSA-8951664 9.863939e-01 0.006 0 0
Integration of energy metabolism R-HSA-163685 9.865430e-01 0.006 0 0
Tryptophan catabolism R-HSA-71240 9.867411e-01 0.006 0 0
Collagen degradation R-HSA-1442490 9.871487e-01 0.006 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 9.872717e-01 0.006 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.875150e-01 0.005 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.876689e-01 0.005 0 0
Maturation of spike protein R-HSA-9694548 9.879079e-01 0.005 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.879079e-01 0.005 0 0
Signaling by Hedgehog R-HSA-5358351 9.879922e-01 0.005 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.886280e-01 0.005 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.886280e-01 0.005 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.889721e-01 0.005 0 0
Translation of Structural Proteins R-HSA-9683701 9.889721e-01 0.005 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.898878e-01 0.004 0 0
Regulation of insulin secretion R-HSA-422356 9.899262e-01 0.004 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.900671e-01 0.004 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.906040e-01 0.004 0 0
Defensins R-HSA-1461973 9.908279e-01 0.004 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.908279e-01 0.004 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.916353e-01 0.004 0 0
Interferon alpha/beta signaling R-HSA-909733 9.917352e-01 0.004 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.917352e-01 0.004 0 0
Hemostasis R-HSA-109582 9.920018e-01 0.003 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.920539e-01 0.003 0 0
Extracellular matrix organization R-HSA-1474244 9.921258e-01 0.003 0 0
Peptide chain elongation R-HSA-156902 9.934081e-01 0.003 0 0
Phospholipid metabolism R-HSA-1483257 9.938618e-01 0.003 0 0
Intraflagellar transport R-HSA-5620924 9.942142e-01 0.003 0 0
Metal ion SLC transporters R-HSA-425410 9.942142e-01 0.003 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.947237e-01 0.002 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.947237e-01 0.002 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.951023e-01 0.002 0 0
Azathioprine ADME R-HSA-9748787 9.951883e-01 0.002 0 0
Protein localization R-HSA-9609507 9.953079e-01 0.002 0 0
Ribosome-associated quality control R-HSA-9948299 9.954255e-01 0.002 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.954547e-01 0.002 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.963192e-01 0.002 0 0
Nucleotide biosynthesis R-HSA-8956320 9.963508e-01 0.002 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.963704e-01 0.002 0 0
Translation of Structural Proteins R-HSA-9694635 9.964732e-01 0.002 0 0
Scavenging of heme from plasma R-HSA-2168880 9.966336e-01 0.001 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.966336e-01 0.001 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.975127e-01 0.001 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.980864e-01 0.001 0 0
Glutathione conjugation R-HSA-156590 9.980864e-01 0.001 0 0
Endogenous sterols R-HSA-211976 9.982550e-01 0.001 0 0
G alpha (q) signalling events R-HSA-416476 9.984019e-01 0.001 0 0
Mitochondrial protein import R-HSA-1268020 9.984088e-01 0.001 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.984526e-01 0.001 0 0
Platelet homeostasis R-HSA-418346 9.986510e-01 0.001 0 0
Classical antibody-mediated complement activation R-HSA-173623 9.986892e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.987216e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.987216e-01 0.001 0 0
Interferon gamma signaling R-HSA-877300 9.988979e-01 0.000 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.988998e-01 0.000 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.989788e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.989968e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.989968e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.990095e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.990834e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.990852e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.990852e-01 0.000 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.991357e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.992394e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.992394e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.993065e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.993065e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.993065e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.993065e-01 0.000 0 0
Eukaryotic Translation Termination R-HSA-72764 9.993816e-01 0.000 0 0
Disease R-HSA-1643685 9.994190e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.994234e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.994742e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.994742e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.995090e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.995206e-01 0.000 0 0
Keratinization R-HSA-6805567 9.995641e-01 0.000 0 0
Selenocysteine synthesis R-HSA-2408557 9.996265e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.996349e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.996686e-01 0.000 0 0
Viral mRNA Translation R-HSA-192823 9.996845e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.997387e-01 0.000 0 0
rRNA processing R-HSA-72312 9.997518e-01 0.000 0 0
Creation of C4 and C2 activators R-HSA-166786 9.997751e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.997842e-01 0.000 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.997933e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.997951e-01 0.000 1 0
Degradation of the extracellular matrix R-HSA-1474228 9.998724e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.998781e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.998906e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.998953e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.998992e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999022e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999478e-01 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 9.999518e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999566e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999619e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999727e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999747e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999773e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999811e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999852e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999857e-01 0.000 0 0
Translation R-HSA-72766 9.999873e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999874e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999888e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999936e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999960e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999961e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999967e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999974e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999977e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999990e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999993e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999993e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999994e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999995e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999995e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999998e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999999e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999999e-01 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 1 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 1 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 3.463896e-14 13.460 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.575406e-13 12.803 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.486589e-13 12.828 0 0
mRNA Splicing R-HSA-72172 3.627099e-13 12.440 0 0
Metabolism of RNA R-HSA-8953854 1.552980e-12 11.809 0 0
Cell Cycle, Mitotic R-HSA-69278 6.131939e-11 10.212 0 0
M Phase R-HSA-68886 1.397412e-10 9.855 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.764974e-09 8.753 0 0
Mitotic Anaphase R-HSA-68882 4.122816e-09 8.385 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 4.718014e-09 8.326 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.877242e-08 7.541 0 0
Separation of Sister Chromatids R-HSA-2467813 4.517401e-08 7.345 0 0
Cellular response to heat stress R-HSA-3371556 5.006500e-08 7.300 0 0
Apoptotic execution phase R-HSA-75153 8.861840e-08 7.052 0 0
Mitotic Prometaphase R-HSA-68877 1.412172e-07 6.850 0 0
Apoptosis R-HSA-109581 2.503640e-07 6.601 0 0
Cell-Cell communication R-HSA-1500931 3.254708e-07 6.487 0 0
G2/M Transition R-HSA-69275 3.748969e-07 6.426 0 0
Mitotic G2-G2/M phases R-HSA-453274 4.797428e-07 6.319 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 8.924673e-07 6.049 0 0
Signaling by ALK in cancer R-HSA-9700206 8.924673e-07 6.049 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.289708e-06 5.890 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.206255e-06 5.494 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 3.237606e-06 5.490 0 0
HSF1-dependent transactivation R-HSA-3371571 5.541117e-06 5.256 0 0
Regulation of CDH1 Function R-HSA-9764561 5.604516e-06 5.251 0 0
Cell Cycle Checkpoints R-HSA-69620 6.138181e-06 5.212 0 0
SARS-CoV-1-host interactions R-HSA-9692914 6.449039e-06 5.191 0 0
Regulation of TP53 Degradation R-HSA-6804757 7.023493e-06 5.153 0 0
Programmed Cell Death R-HSA-5357801 8.461691e-06 5.073 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.079690e-05 4.967 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.112156e-05 4.954 0 0
PKR-mediated signaling R-HSA-9833482 1.206324e-05 4.919 0 0
HIV Life Cycle R-HSA-162587 1.370386e-05 4.863 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.528829e-05 4.816 0 0
Protein ubiquitination R-HSA-8852135 1.584730e-05 4.800 0 0
Cell junction organization R-HSA-446728 1.719261e-05 4.765 0 0
Aggrephagy R-HSA-9646399 1.952730e-05 4.709 0 0
Attenuation phase R-HSA-3371568 1.952730e-05 4.709 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.091485e-05 4.680 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.293464e-05 4.640 0 0
Recycling pathway of L1 R-HSA-437239 3.152140e-05 4.501 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 3.245931e-05 4.489 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.381664e-05 4.471 0 0
Nervous system development R-HSA-9675108 3.576163e-05 4.447 0 0
Chaperone Mediated Autophagy R-HSA-9613829 3.872133e-05 4.412 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.767219e-05 4.424 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 5.542726e-05 4.256 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 5.663467e-05 4.247 0 0
G2/M Checkpoints R-HSA-69481 5.911815e-05 4.228 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 6.438443e-05 4.191 0 0
Adherens junctions interactions R-HSA-418990 6.233018e-05 4.205 0 0
HIV Infection R-HSA-162906 6.617471e-05 4.179 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 8.217901e-05 4.085 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 8.217901e-05 4.085 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 9.768826e-05 4.010 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 9.768826e-05 4.010 0 0
Axon guidance R-HSA-422475 1.007746e-04 3.997 0 0
Chromatin organization R-HSA-4839726 1.011924e-04 3.995 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.054119e-04 3.977 0 0
HSF1 activation R-HSA-3371511 1.159395e-04 3.936 0 0
Cellular responses to stimuli R-HSA-8953897 1.150509e-04 3.939 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.337061e-04 3.874 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.329013e-04 3.876 0 0
Cellular responses to stress R-HSA-2262752 1.322805e-04 3.879 0 0
S Phase R-HSA-69242 1.487638e-04 3.828 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.517363e-04 3.819 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.554539e-04 3.808 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.577926e-04 3.802 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 1.668943e-04 3.778 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.692685e-04 3.771 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.764899e-04 3.753 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.095043e-04 3.679 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.123318e-04 3.673 0 0
Host Interactions of HIV factors R-HSA-162909 2.137219e-04 3.670 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.563448e-04 3.591 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.774434e-04 3.557 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 3.252631e-04 3.488 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 3.252631e-04 3.488 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 3.290410e-04 3.483 0 0
Post NMDA receptor activation events R-HSA-438064 3.204833e-04 3.494 0 0
Smooth Muscle Contraction R-HSA-445355 3.290410e-04 3.483 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 3.628543e-04 3.440 0 0
NF-kB is activated and signals survival R-HSA-209560 3.628543e-04 3.440 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 3.695547e-04 3.432 0 0
Selective autophagy R-HSA-9663891 3.645505e-04 3.438 0 0
ISG15 antiviral mechanism R-HSA-1169408 3.934508e-04 3.405 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 3.995384e-04 3.398 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 4.228549e-04 3.374 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 4.336577e-04 3.363 0 0
Cell-cell junction organization R-HSA-421270 4.324063e-04 3.364 0 0
Chromatin modifying enzymes R-HSA-3247509 4.474237e-04 3.349 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.947749e-04 3.306 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 5.361579e-04 3.271 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 5.326712e-04 3.274 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 5.361692e-04 3.271 0 0
Membrane Trafficking R-HSA-199991 5.678551e-04 3.246 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 6.363997e-04 3.196 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 6.732179e-04 3.172 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 7.012620e-04 3.154 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 7.289500e-04 3.137 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 8.157859e-04 3.088 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 8.301242e-04 3.081 0 0
MITF-M-dependent gene expression R-HSA-9856651 8.308033e-04 3.081 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 8.427693e-04 3.074 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 9.152014e-04 3.038 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 9.097703e-04 3.041 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 9.135762e-04 3.039 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 9.580807e-04 3.019 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 9.738368e-04 3.012 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 9.794195e-04 3.009 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 9.836906e-04 3.007 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 9.887054e-04 3.005 0 0
Josephin domain DUBs R-HSA-5689877 9.988550e-04 3.000 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.045453e-03 2.981 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.043298e-03 2.982 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.075371e-03 2.968 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.085522e-03 2.964 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.089587e-03 2.963 0 0
L1CAM interactions R-HSA-373760 1.091583e-03 2.962 0 0
Translation initiation complex formation R-HSA-72649 1.143915e-03 2.942 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.451099e-03 2.838 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.451099e-03 2.838 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.419705e-03 2.848 0 0
Ca-dependent events R-HSA-111996 1.522048e-03 2.818 0 0
CaM pathway R-HSA-111997 1.438980e-03 2.842 0 0
Calmodulin induced events R-HSA-111933 1.438980e-03 2.842 0 0
Degradation of CDH1 R-HSA-9766229 1.547684e-03 2.810 0 0
Autophagy R-HSA-9612973 1.380210e-03 2.860 0 0
Neurodegenerative Diseases R-HSA-8863678 1.314176e-03 2.881 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.314176e-03 2.881 0 0
p75NTR signals via NF-kB R-HSA-193639 1.419705e-03 2.848 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.419705e-03 2.848 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.419705e-03 2.848 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.482816e-03 2.829 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.321090e-03 2.879 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.419705e-03 2.848 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.419705e-03 2.848 0 0
Mitotic Prophase R-HSA-68875 1.600656e-03 2.796 0 0
Nephrin family interactions R-HSA-373753 1.611715e-03 2.793 0 0
Hedgehog 'off' state R-HSA-5610787 1.808054e-03 2.743 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.817617e-03 2.740 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.928643e-03 2.715 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.040693e-03 2.690 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 2.044650e-03 2.689 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.052674e-03 2.688 0 0
Muscle contraction R-HSA-397014 2.108046e-03 2.676 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.360433e-03 2.627 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.360433e-03 2.627 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.309955e-03 2.636 0 0
Stabilization of p53 R-HSA-69541 2.410386e-03 2.618 0 0
rRNA processing R-HSA-72312 2.406399e-03 2.619 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.282697e-03 2.642 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.480874e-03 2.605 0 0
Striated Muscle Contraction R-HSA-390522 2.728815e-03 2.564 0 0
Signaling by VEGF R-HSA-194138 2.738081e-03 2.563 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 2.780369e-03 2.556 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 2.830730e-03 2.548 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.830730e-03 2.548 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.832472e-03 2.548 0 0
Macroautophagy R-HSA-1632852 2.985924e-03 2.525 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 3.014158e-03 2.521 0 0
Signaling by Hippo R-HSA-2028269 3.189658e-03 2.496 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 3.189658e-03 2.496 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.285948e-03 2.483 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 3.285948e-03 2.483 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 3.313655e-03 2.480 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.760300e-03 2.425 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 3.549395e-03 2.450 0 0
PCP/CE pathway R-HSA-4086400 3.641560e-03 2.439 0 0
DNA Repair R-HSA-73894 3.515321e-03 2.454 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 3.641560e-03 2.439 0 0
Signaling by RAF1 mutants R-HSA-9656223 3.854865e-03 2.414 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.854865e-03 2.414 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 3.854865e-03 2.414 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 3.854865e-03 2.414 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.979842e-03 2.400 0 0
Transport of connexons to the plasma membrane R-HSA-190872 4.051331e-03 2.392 0 0
Gene expression (Transcription) R-HSA-74160 4.233185e-03 2.373 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 4.265552e-03 2.370 0 0
DNA Damage Bypass R-HSA-73893 4.317458e-03 2.365 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.317458e-03 2.365 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.317458e-03 2.365 0 0
Gap junction trafficking and regulation R-HSA-157858 4.317458e-03 2.365 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 5.078653e-03 2.294 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 4.905504e-03 2.309 0 0
Processing of DNA double-strand break ends R-HSA-5693607 5.005224e-03 2.301 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 5.244973e-03 2.280 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 5.244973e-03 2.280 0 0
Regulation of signaling by CBL R-HSA-912631 5.078653e-03 2.294 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 5.087351e-03 2.294 0 0
Maturation of protein E R-HSA-9683683 5.244973e-03 2.280 0 0
Maturation of protein E R-HSA-9694493 5.244973e-03 2.280 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 4.854482e-03 2.314 0 0
Degradation of DVL R-HSA-4641258 5.254255e-03 2.279 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 5.584108e-03 2.253 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 5.584108e-03 2.253 0 0
Pexophagy R-HSA-9664873 5.584108e-03 2.253 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 5.747465e-03 2.241 0 0
Gap junction trafficking R-HSA-190828 5.919063e-03 2.228 0 0
DNA Double Strand Break Response R-HSA-5693606 6.086185e-03 2.216 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 6.290238e-03 2.201 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 6.364186e-03 2.196 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 6.364186e-03 2.196 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 6.364186e-03 2.196 0 0
Orc1 removal from chromatin R-HSA-68949 6.372943e-03 2.196 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 6.772753e-03 2.169 0 0
DAG and IP3 signaling R-HSA-1489509 6.772753e-03 2.169 0 0
Fanconi Anemia Pathway R-HSA-6783310 6.772753e-03 2.169 0 0
Regulation of TP53 Activity R-HSA-5633007 6.818351e-03 2.166 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 7.704925e-03 2.113 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 7.704925e-03 2.113 0 0
Signaling downstream of RAS mutants R-HSA-9649948 7.719819e-03 2.112 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 7.719819e-03 2.112 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 7.719819e-03 2.112 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 7.207799e-03 2.142 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 8.179585e-03 2.087 0 0
Amplification of signal from the kinetochores R-HSA-141424 8.179585e-03 2.087 0 0
Signaling by RAS mutants R-HSA-6802949 7.719819e-03 2.112 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 7.103302e-03 2.149 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 7.766228e-03 2.110 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 8.284875e-03 2.082 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 8.390358e-03 2.076 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 8.390358e-03 2.076 0 0
Mitotic Spindle Checkpoint R-HSA-69618 8.397106e-03 2.076 0 0
Glycolysis R-HSA-70171 8.397106e-03 2.076 0 0
Deubiquitination R-HSA-5688426 8.990000e-03 2.046 0 0
Co-inhibition by PD-1 R-HSA-389948 9.093681e-03 2.041 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 9.293676e-03 2.032 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.322690e-03 2.030 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.322690e-03 2.030 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.341589e-03 2.030 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 9.341589e-03 2.030 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 9.341589e-03 2.030 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 9.397990e-03 2.027 0 0
Nuclear import of Rev protein R-HSA-180746 9.707092e-03 2.013 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 9.707092e-03 2.013 0 0
Interleukin-12 family signaling R-HSA-447115 9.830267e-03 2.007 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 9.920358e-03 2.003 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 9.955976e-03 2.002 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 9.955976e-03 2.002 0 0
TNF signaling R-HSA-75893 1.023602e-02 1.990 0 0
Signaling by EGFR R-HSA-177929 1.023602e-02 1.990 0 0
Interferon Signaling R-HSA-913531 1.037025e-02 1.984 0 0
SARS-CoV Infections R-HSA-9679506 1.099777e-02 1.959 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.121738e-02 1.950 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.121738e-02 1.950 0 0
Late endosomal microautophagy R-HSA-9615710 1.147507e-02 1.940 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.269371e-02 1.896 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.133514e-02 1.946 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.283911e-02 1.891 0 0
VLDLR internalisation and degradation R-HSA-8866427 1.283911e-02 1.891 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.287214e-02 1.890 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.247784e-02 1.904 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.322857e-02 1.878 0 0
mTORC1-mediated signalling R-HSA-166208 1.121895e-02 1.950 0 0
Homology Directed Repair R-HSA-5693538 1.131802e-02 1.946 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 1.121895e-02 1.950 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 1.121738e-02 1.950 0 0
Regulation of PTEN localization R-HSA-8948747 1.121738e-02 1.950 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.283911e-02 1.891 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.209511e-02 1.917 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.337265e-02 1.874 0 0
Influenza Infection R-HSA-168255 1.349694e-02 1.870 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.369480e-02 1.863 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 1.369480e-02 1.863 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.407028e-02 1.852 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.408784e-02 1.851 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.416068e-02 1.849 0 0
Metabolism of non-coding RNA R-HSA-194441 1.416623e-02 1.849 0 0
snRNP Assembly R-HSA-191859 1.416623e-02 1.849 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.471532e-02 1.832 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.471532e-02 1.832 0 0
Interleukin-12 signaling R-HSA-9020591 1.502957e-02 1.823 0 0
PKA activation R-HSA-163615 1.512529e-02 1.820 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.512529e-02 1.820 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.512529e-02 1.820 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.525927e-02 1.816 0 0
Formation of annular gap junctions R-HSA-196025 1.537653e-02 1.813 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 1.537653e-02 1.813 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.537653e-02 1.813 0 0
Modulation by Mtb of host immune system R-HSA-9637628 1.537653e-02 1.813 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.537653e-02 1.813 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.548975e-02 1.810 0 0
Budding and maturation of HIV virion R-HSA-162588 1.548975e-02 1.810 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.548975e-02 1.810 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.623916e-02 1.789 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.623916e-02 1.789 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.820916e-02 1.740 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 1.897411e-02 1.722 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.897411e-02 1.722 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.944661e-02 1.711 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.573520e-02 1.803 0 0
mRNA 3'-end processing R-HSA-72187 1.573520e-02 1.803 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.752290e-02 1.756 0 0
Meiotic synapsis R-HSA-1221632 1.752290e-02 1.756 0 0
Ub-specific processing proteases R-HSA-5689880 1.632283e-02 1.787 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.736243e-02 1.760 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.736243e-02 1.760 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.581459e-02 1.801 0 0
PLC beta mediated events R-HSA-112043 1.736271e-02 1.760 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.623916e-02 1.789 0 0
EPH-Ephrin signaling R-HSA-2682334 1.640392e-02 1.785 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.710628e-02 1.767 0 0
Signaling by ERBB2 R-HSA-1227986 1.570307e-02 1.804 0 0
Signaling by ALK R-HSA-201556 1.897411e-02 1.722 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.897411e-02 1.722 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 1.736243e-02 1.760 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.862857e-02 1.730 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.869786e-02 1.728 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.602084e-02 1.795 0 0
Kinesins R-HSA-983189 1.570307e-02 1.804 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.623916e-02 1.789 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.576876e-02 1.802 0 0
Signaling by Hedgehog R-HSA-5358351 1.613730e-02 1.792 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.579237e-02 1.802 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 1.573520e-02 1.803 0 0
Signaling by ROBO receptors R-HSA-376176 1.800543e-02 1.745 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.945760e-02 1.711 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.968831e-02 1.706 0 0
TCR signaling R-HSA-202403 1.976132e-02 1.704 0 0
G1/S Transition R-HSA-69206 1.980370e-02 1.703 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 2.019029e-02 1.695 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 2.019029e-02 1.695 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 2.019029e-02 1.695 0 0
NRIF signals cell death from the nucleus R-HSA-205043 2.019029e-02 1.695 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.028169e-02 1.693 0 0
Gap junction degradation R-HSA-190873 2.039413e-02 1.690 0 0
ALK mutants bind TKIs R-HSA-9700645 2.039413e-02 1.690 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 2.039413e-02 1.690 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.039413e-02 1.690 0 0
Cellular response to mitochondrial stress R-HSA-9840373 2.039413e-02 1.690 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 2.039413e-02 1.690 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.039458e-02 1.690 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 2.043408e-02 1.690 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.043408e-02 1.690 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.107281e-02 1.676 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.107281e-02 1.676 0 0
Semaphorin interactions R-HSA-373755 2.107281e-02 1.676 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.140954e-02 1.669 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 2.140954e-02 1.669 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.140954e-02 1.669 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.140954e-02 1.669 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.149405e-02 1.668 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.168817e-02 1.664 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 2.170828e-02 1.663 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.277488e-02 1.643 0 0
Folding of actin by CCT/TriC R-HSA-390450 2.631140e-02 1.580 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.561116e-02 1.592 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.483757e-02 1.605 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.328594e-02 1.633 0 0
Dual incision in TC-NER R-HSA-6782135 2.879515e-02 1.541 0 0
Nucleotide Excision Repair R-HSA-5696398 2.605343e-02 1.584 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.939419e-02 1.532 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.564503e-02 1.591 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 2.561116e-02 1.592 0 0
COPI-mediated anterograde transport R-HSA-6807878 2.411852e-02 1.618 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.406170e-02 1.619 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 2.483757e-02 1.605 0 0
Mitophagy R-HSA-5205647 2.640640e-02 1.578 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.803543e-02 1.552 1 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 2.852092e-02 1.545 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.762252e-02 1.559 0 0
Protein methylation R-HSA-8876725 2.472223e-02 1.607 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 2.980620e-02 1.526 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 2.980620e-02 1.526 0 0
Death Receptor Signaling R-HSA-73887 2.576870e-02 1.589 0 0
Vesicle-mediated transport R-HSA-5653656 2.959044e-02 1.529 0 0
Oncogene Induced Senescence R-HSA-2559585 2.980620e-02 1.526 0 0
Vpu mediated degradation of CD4 R-HSA-180534 2.328594e-02 1.633 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 2.640640e-02 1.578 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 2.640640e-02 1.578 0 0
Regulation of Apoptosis R-HSA-169911 2.980620e-02 1.526 0 0
Calnexin/calreticulin cycle R-HSA-901042 2.640640e-02 1.578 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 2.472223e-02 1.607 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.472223e-02 1.607 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.522492e-02 1.598 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 2.985992e-02 1.525 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.872875e-02 1.542 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.996774e-02 1.523 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 2.996774e-02 1.523 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.996774e-02 1.523 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.996774e-02 1.523 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.996774e-02 1.523 0 0
Assembly Of The HIV Virion R-HSA-175474 2.996774e-02 1.523 0 0
Unfolded Protein Response (UPR) R-HSA-381119 3.010333e-02 1.521 0 0
G-protein mediated events R-HSA-112040 3.020799e-02 1.520 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.036800e-02 1.518 0 0
UCH proteinases R-HSA-5689603 3.115232e-02 1.507 0 0
Meiosis R-HSA-1500620 3.172402e-02 1.499 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 3.196261e-02 1.495 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 3.196261e-02 1.495 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 3.196261e-02 1.495 0 0
Protein folding R-HSA-391251 3.199945e-02 1.495 0 0
Eukaryotic Translation Elongation R-HSA-156842 3.199945e-02 1.495 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 3.255699e-02 1.487 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 3.255699e-02 1.487 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.255699e-02 1.487 0 0
DARPP-32 events R-HSA-180024 3.255699e-02 1.487 0 0
Hedgehog ligand biogenesis R-HSA-5358346 3.267938e-02 1.486 0 0
PECAM1 interactions R-HSA-210990 3.315676e-02 1.479 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 3.315676e-02 1.479 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 3.349530e-02 1.475 0 0
FLT3 signaling in disease R-HSA-9682385 3.349530e-02 1.475 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 3.450832e-02 1.462 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 3.478317e-02 1.459 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 3.562334e-02 1.448 0 0
Disorders of Developmental Biology R-HSA-9675151 3.562334e-02 1.448 0 0
Glucose metabolism R-HSA-70326 3.578670e-02 1.446 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 3.593800e-02 1.444 0 0
Regulation of endogenous retroelements R-HSA-9842860 3.664945e-02 1.436 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.695729e-02 1.432 0 0
Activation of BH3-only proteins R-HSA-114452 3.695729e-02 1.432 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 3.701146e-02 1.432 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.748283e-02 1.426 0 0
Degradation of AXIN R-HSA-4641257 3.748283e-02 1.426 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 3.748283e-02 1.426 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.764568e-02 1.424 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 4.646336e-02 1.333 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 4.646336e-02 1.333 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 4.646336e-02 1.333 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 4.646336e-02 1.333 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 4.646336e-02 1.333 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 4.646336e-02 1.333 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 4.646336e-02 1.333 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 4.646336e-02 1.333 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 4.646336e-02 1.333 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 4.646336e-02 1.333 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 4.646336e-02 1.333 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 4.646336e-02 1.333 0 0
Recycling of eIF2:GDP R-HSA-72731 5.523126e-02 1.258 0 0
Long-term potentiation R-HSA-9620244 5.210173e-02 1.283 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 4.173189e-02 1.380 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 4.173189e-02 1.380 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 5.885851e-02 1.230 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 5.243656e-02 1.280 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 5.243656e-02 1.280 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 5.243656e-02 1.280 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 5.837891e-02 1.234 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 4.087322e-02 1.389 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 4.499825e-02 1.347 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 3.941558e-02 1.404 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.704949e-02 1.327 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.121556e-02 1.291 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.121556e-02 1.291 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 4.879103e-02 1.312 0 0
Centrosome maturation R-HSA-380287 5.642133e-02 1.249 0 0
Post-translational protein phosphorylation R-HSA-8957275 5.116878e-02 1.291 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 4.638499e-02 1.334 0 0
Translesion Synthesis by POLH R-HSA-110320 5.679204e-02 1.246 0 0
Regulation of necroptotic cell death R-HSA-5675482 5.243656e-02 1.280 0 0
Metalloprotease DUBs R-HSA-5689901 5.885851e-02 1.230 0 0
Myogenesis R-HSA-525793 5.885851e-02 1.230 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 4.189848e-02 1.378 0 0
Regulation of mitotic cell cycle R-HSA-453276 4.189848e-02 1.378 0 0
Cellular response to hypoxia R-HSA-1234174 5.217915e-02 1.283 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 4.908204e-02 1.309 0 0
EGFR downregulation R-HSA-182971 4.173189e-02 1.380 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 4.233223e-02 1.373 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.727979e-02 1.325 0 0
HDMs demethylate histones R-HSA-3214842 5.210173e-02 1.283 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 4.173189e-02 1.380 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 4.704949e-02 1.327 0 0
tRNA processing in the nucleus R-HSA-6784531 4.097696e-02 1.387 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 4.189848e-02 1.378 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 3.943451e-02 1.404 0 0
Signaling by FGFR2 R-HSA-5654738 4.233223e-02 1.373 0 0
Intracellular signaling by second messengers R-HSA-9006925 4.433134e-02 1.353 0 0
Regulation of PTEN stability and activity R-HSA-8948751 3.941558e-02 1.404 0 0
Ion homeostasis R-HSA-5578775 5.121556e-02 1.291 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 5.243656e-02 1.280 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 4.173189e-02 1.380 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 4.939219e-02 1.306 0 0
Sema4D in semaphorin signaling R-HSA-400685 5.210173e-02 1.283 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 4.503234e-02 1.346 0 0
Platelet degranulation R-HSA-114608 3.953513e-02 1.403 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 4.559305e-02 1.341 0 0
Rap1 signalling R-HSA-392517 5.679204e-02 1.246 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 4.097696e-02 1.387 0 0
Signal Transduction R-HSA-162582 4.674499e-02 1.330 1 0
ESR-mediated signaling R-HSA-8939211 5.642242e-02 1.249 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 5.523126e-02 1.258 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 5.837891e-02 1.234 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 4.499825e-02 1.347 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 5.444517e-02 1.264 0 0
TGFBR3 expression R-HSA-9839394 5.210173e-02 1.283 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.879103e-02 1.312 0 0
Cytokine Signaling in Immune system R-HSA-1280215 4.440290e-02 1.353 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 4.968460e-02 1.304 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 4.968460e-02 1.304 0 0
ABC-family proteins mediated transport R-HSA-382556 5.786333e-02 1.238 0 0
Viral Infection Pathways R-HSA-9824446 4.318053e-02 1.365 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 4.007067e-02 1.397 0 0
IRAK1 recruits IKK complex R-HSA-937039 4.968460e-02 1.304 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 4.968460e-02 1.304 0 0
Signaling by NOTCH4 R-HSA-9013694 5.251236e-02 1.280 0 0
FLT3 Signaling R-HSA-9607240 5.656647e-02 1.247 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 5.656647e-02 1.247 0 0
SARS-CoV-2 Infection R-HSA-9694516 5.600306e-02 1.252 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 5.900573e-02 1.229 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 6.026634e-02 1.220 0 0
Cellular Senescence R-HSA-2559583 6.107914e-02 1.214 0 0
Cilium Assembly R-HSA-5617833 6.128263e-02 1.213 0 0
Interleukin-1 signaling R-HSA-9020702 6.142527e-02 1.212 0 0
MAP2K and MAPK activation R-HSA-5674135 6.214920e-02 1.207 0 0
Degradation of CRY and PER proteins R-HSA-9932298 6.214920e-02 1.207 0 0
Signaling by FGFR1 in disease R-HSA-5655302 6.214920e-02 1.207 0 0
MyD88-independent TLR4 cascade R-HSA-166166 6.340877e-02 1.198 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 6.340877e-02 1.198 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.472005e-02 1.189 0 0
Dual Incision in GG-NER R-HSA-5696400 6.472005e-02 1.189 0 0
Gap junction assembly R-HSA-190861 6.472005e-02 1.189 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 6.515745e-02 1.186 0 0
Negative regulation of MET activity R-HSA-6807004 6.515745e-02 1.186 0 0
Transcription of the HIV genome R-HSA-167172 6.527199e-02 1.185 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 6.611382e-02 1.180 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 6.611382e-02 1.180 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 6.611382e-02 1.180 0 0
MTOR signalling R-HSA-165159 6.806429e-02 1.167 0 0
XBP1(S) activates chaperone genes R-HSA-381038 6.815005e-02 1.167 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 6.871981e-02 1.163 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 6.871981e-02 1.163 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 6.871981e-02 1.163 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 6.871981e-02 1.163 0 0
Type I hemidesmosome assembly R-HSA-446107 6.917810e-02 1.160 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 6.917810e-02 1.160 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 6.974417e-02 1.156 0 0
Regulation of KIT signaling R-HSA-1433559 6.997237e-02 1.155 0 0
Translation R-HSA-72766 7.111428e-02 1.148 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 7.146202e-02 1.146 0 0
MAPK family signaling cascades R-HSA-5683057 7.286999e-02 1.137 0 0
Opioid Signalling R-HSA-111885 7.299146e-02 1.137 0 0
Response of endothelial cells to shear stress R-HSA-9860931 7.299146e-02 1.137 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 7.299146e-02 1.137 0 0
HIV elongation arrest and recovery R-HSA-167287 7.386760e-02 1.132 0 0
Pausing and recovery of HIV elongation R-HSA-167290 7.386760e-02 1.132 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 7.386760e-02 1.132 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 7.417365e-02 1.130 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 7.417365e-02 1.130 0 0
Basigin interactions R-HSA-210991 7.417365e-02 1.130 0 0
Signaling by SCF-KIT R-HSA-1433557 7.431360e-02 1.129 0 0
Signaling by FGFR4 R-HSA-5654743 7.431360e-02 1.129 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 7.510849e-02 1.124 0 0
Formation of a pool of free 40S subunits R-HSA-72689 7.510849e-02 1.124 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 7.860518e-02 1.105 0 0
RNA Polymerase III Transcription R-HSA-74158 7.860518e-02 1.105 0 0
RET signaling R-HSA-8853659 7.860518e-02 1.105 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 7.873310e-02 1.104 0 0
G1 Phase R-HSA-69236 8.089790e-02 1.092 0 0
Cyclin D associated events in G1 R-HSA-69231 8.089790e-02 1.092 0 0
PTEN Regulation R-HSA-6807070 8.147361e-02 1.089 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 8.148104e-02 1.089 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 8.148104e-02 1.089 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 8.148104e-02 1.089 0 0
Translesion synthesis by REV1 R-HSA-110312 8.148104e-02 1.089 0 0
DCC mediated attractive signaling R-HSA-418885 8.148104e-02 1.089 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 8.173225e-02 1.088 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 8.173225e-02 1.088 0 0
ER-Phagosome pathway R-HSA-1236974 8.183276e-02 1.087 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.211723e-02 1.086 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 8.211723e-02 1.086 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 8.211723e-02 1.086 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 8.383162e-02 1.077 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 8.383162e-02 1.077 0 0
MHC class II antigen presentation R-HSA-2132295 8.400151e-02 1.076 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 8.413918e-02 1.075 0 0
ARMS-mediated activation R-HSA-170984 8.454250e-02 1.073 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 8.454250e-02 1.073 0 0
Calcineurin activates NFAT R-HSA-2025928 8.454250e-02 1.073 0 0
GP1b-IX-V activation signalling R-HSA-430116 8.454250e-02 1.073 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 8.454250e-02 1.073 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 8.579031e-02 1.067 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 8.614826e-02 1.065 0 0
Downstream TCR signaling R-HSA-202424 8.675444e-02 1.062 0 0
Signaling by FGFR3 R-HSA-5654741 8.781681e-02 1.056 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 8.781681e-02 1.056 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 8.883878e-02 1.051 0 0
Adaptive Immune System R-HSA-1280218 8.903399e-02 1.050 0 0
Synthesis of DNA R-HSA-69239 9.051679e-02 1.043 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.085757e-02 1.042 0 0
Ion transport by P-type ATPases R-HSA-936837 9.335144e-02 1.030 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 9.370852e-02 1.028 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 9.370852e-02 1.028 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 9.370852e-02 1.028 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 9.385882e-02 1.028 0 0
Translesion synthesis by POLI R-HSA-5656121 9.385882e-02 1.028 0 0
Prolonged ERK activation events R-HSA-169893 9.385882e-02 1.028 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 9.385882e-02 1.028 0 0
Regulation of BACH1 activity R-HSA-9708530 9.385882e-02 1.028 0 0
Negative regulation of FLT3 R-HSA-9706369 9.385882e-02 1.028 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.408842e-02 1.026 0 0
FGFR2 alternative splicing R-HSA-6803529 9.411820e-02 1.026 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 9.506887e-02 1.022 0 0
IRE1alpha activates chaperones R-HSA-381070 9.714284e-02 1.013 0 0
Interleukin-1 family signaling R-HSA-446652 9.737425e-02 1.012 0 0
Developmental Biology R-HSA-1266738 9.900932e-02 1.004 0 0
Signaling by Interleukins R-HSA-449147 9.975725e-02 1.001 0 0
Trafficking of AMPA receptors R-HSA-399719 1.000811e-01 1.000 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.003957e-01 0.998 0 0
Regulation of CDH11 function R-HSA-9762292 1.012136e-01 0.995 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.012136e-01 0.995 0 0
CASP4 inflammasome assembly R-HSA-9948001 1.012136e-01 0.995 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.015974e-01 0.993 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.024212e-01 0.990 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.035138e-01 0.985 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 1.050164e-01 0.979 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.057800e-01 0.976 0 0
Translesion synthesis by POLK R-HSA-5655862 1.070666e-01 0.970 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 1.070666e-01 0.970 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.082581e-01 0.966 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.567888e-01 0.805 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.567888e-01 0.805 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.567888e-01 0.805 0 0
Defective ACTH causes obesity and POMCD R-HSA-5579031 1.567888e-01 0.805 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.567888e-01 0.805 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.567888e-01 0.805 0 0
SARS-CoV-1 targets PDZ proteins in cell-cell junction R-HSA-9692912 1.567888e-01 0.805 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.567888e-01 0.805 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.567888e-01 0.805 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 1.208349e-01 0.918 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 1.495831e-01 0.825 0 0
Autointegration results in viral DNA circles R-HSA-177539 1.795073e-01 0.746 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 1.379922e-01 0.860 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.379922e-01 0.860 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 2.102237e-01 0.677 0 0
TRIF-mediated programmed cell death R-HSA-2562578 2.102237e-01 0.677 0 0
Disinhibition of SNARE formation R-HSA-114516 2.102237e-01 0.677 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.102237e-01 0.677 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.578476e-01 0.802 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.578476e-01 0.802 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.578476e-01 0.802 0 0
Scavenging by Class F Receptors R-HSA-3000484 1.578476e-01 0.802 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.578476e-01 0.802 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.578476e-01 0.802 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.578476e-01 0.802 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.578476e-01 0.802 0 0
GAB1 signalosome R-HSA-180292 1.357884e-01 0.867 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 1.357884e-01 0.867 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.672387e-01 0.777 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 1.672387e-01 0.777 0 0
Cristae formation R-HSA-8949613 1.542729e-01 0.812 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.305422e-01 0.884 0 0
HIV Transcription Elongation R-HSA-167169 1.111407e-01 0.954 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 1.111407e-01 0.954 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.111407e-01 0.954 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.105611e-01 0.956 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 1.395387e-01 0.855 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.321665e-01 0.879 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 2.157982e-01 0.666 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 1.936624e-01 0.713 0 0
Ribosome-associated quality control R-HSA-9948299 1.207213e-01 0.918 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 1.935947e-01 0.713 0 0
Peptide chain elongation R-HSA-156902 2.112950e-01 0.675 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.896431e-01 0.722 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.799672e-01 0.745 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.799672e-01 0.745 0 0
Cellular response to starvation R-HSA-9711097 1.798149e-01 0.745 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 1.123593e-01 0.949 0 0
RAF activation R-HSA-5673000 1.415798e-01 0.849 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.521963e-01 0.818 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.838465e-01 0.736 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.202395e-01 0.920 0 0
Frs2-mediated activation R-HSA-170968 1.785112e-01 0.748 0 0
Co-stimulation by CD28 R-HSA-389356 2.053816e-01 0.687 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.173618e-01 0.663 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 2.185326e-01 0.660 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.578476e-01 0.802 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.542729e-01 0.812 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.936624e-01 0.713 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 1.711492e-01 0.767 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 1.785112e-01 0.748 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.589136e-01 0.799 0 0
Integration of provirus R-HSA-162592 1.379922e-01 0.860 0 0
Repression of WNT target genes R-HSA-4641265 1.578476e-01 0.802 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.542729e-01 0.812 1 1
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.956444e-01 0.709 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 1.305422e-01 0.884 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 1.239119e-01 0.907 0 0
Pyrophosphate hydrolysis R-HSA-71737 1.208349e-01 0.918 0 0
Signaling by WNT R-HSA-195721 1.102411e-01 0.958 1 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 1.828511e-01 0.738 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 1.208349e-01 0.918 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.578476e-01 0.802 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 1.795073e-01 0.746 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.795073e-01 0.746 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.963663e-01 0.707 0 0
Diseases of programmed cell death R-HSA-9645723 1.317832e-01 0.880 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.432115e-01 0.844 0 0
Signaling by FGFR R-HSA-190236 1.458997e-01 0.836 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.037928e-01 0.691 0 0
Inhibition of PKR R-HSA-169131 1.567888e-01 0.805 0 0
Reelin signalling pathway R-HSA-8866376 1.208349e-01 0.918 0 0
CREB phosphorylation R-HSA-199920 1.795073e-01 0.746 0 0
Bicarbonate transporters R-HSA-425381 1.190718e-01 0.924 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 1.210595e-01 0.917 0 0
PKA activation in glucagon signalling R-HSA-164378 1.357884e-01 0.867 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 1.415798e-01 0.849 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.602335e-01 0.795 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.404876e-01 0.852 0 0
Intraflagellar transport R-HSA-5620924 2.053816e-01 0.687 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.357884e-01 0.867 0 0
Signaling by FGFR4 in disease R-HSA-5655291 1.998580e-01 0.699 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.199363e-01 0.921 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.766238e-01 0.753 0 0
Regulation of pyruvate metabolism R-HSA-9861718 1.822207e-01 0.739 0 0
Signaling by FGFR1 R-HSA-5654736 1.848468e-01 0.733 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.101480e-01 0.958 0 0
Signaling by FGFR in disease R-HSA-1226099 1.681357e-01 0.774 0 0
Neurexins and neuroligins R-HSA-6794361 1.453606e-01 0.838 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.495831e-01 0.825 0 0
Nef and signal transduction R-HSA-164944 1.795073e-01 0.746 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.199363e-01 0.921 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.273414e-01 0.895 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.321665e-01 0.879 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.579062e-01 0.802 0 0
Signaling by PTK6 R-HSA-8848021 1.579062e-01 0.802 0 0
Interleukin-7 signaling R-HSA-1266695 1.285631e-01 0.891 0 0
Signaling by TGFB family members R-HSA-9006936 1.920907e-01 0.716 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.297088e-01 0.887 0 0
Signaling by KIT in disease R-HSA-9669938 2.185326e-01 0.660 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 1.795073e-01 0.746 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.672387e-01 0.777 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.199363e-01 0.921 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.199363e-01 0.921 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.838465e-01 0.736 0 0
RAS processing R-HSA-9648002 2.025836e-01 0.693 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.848468e-01 0.733 0 0
Iron uptake and transport R-HSA-917937 1.768694e-01 0.752 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 2.084818e-01 0.681 0 0
Formation of definitive endoderm R-HSA-9823730 1.672387e-01 0.777 0 0
Signal regulatory protein family interactions R-HSA-391160 1.998580e-01 0.699 0 0
Reproduction R-HSA-1474165 1.888871e-01 0.724 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.185326e-01 0.660 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.131170e-01 0.946 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.102237e-01 0.677 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 2.102237e-01 0.677 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.202395e-01 0.920 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.455364e-01 0.837 0 0
Potential therapeutics for SARS R-HSA-9679191 1.956313e-01 0.709 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.471893e-01 0.832 0 0
Plasma lipoprotein clearance R-HSA-8964043 2.025836e-01 0.693 0 0
Hedgehog 'on' state R-HSA-5632684 1.432360e-01 0.844 0 0
Pervasive developmental disorders R-HSA-9005895 1.578476e-01 0.802 0 0
Disorders of Nervous System Development R-HSA-9697154 1.578476e-01 0.802 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.578476e-01 0.802 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.357884e-01 0.867 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 1.838465e-01 0.736 0 0
Signaling by TGFBR3 R-HSA-9839373 1.822207e-01 0.739 0 0
ABC transporter disorders R-HSA-5619084 2.042804e-01 0.690 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 1.838465e-01 0.736 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 1.785112e-01 0.748 0 0
Interleukin-37 signaling R-HSA-9008059 1.963663e-01 0.707 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 2.185326e-01 0.660 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.848468e-01 0.733 0 0
Non-canonical inflammasome activation R-HSA-9686114 1.998580e-01 0.699 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 1.998580e-01 0.699 0 0
HDL assembly R-HSA-8963896 1.998580e-01 0.699 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.432360e-01 0.844 0 0
Glycogen storage diseases R-HSA-3229121 1.210595e-01 0.917 0 0
Glycogen synthesis R-HSA-3322077 1.672387e-01 0.777 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 1.329006e-01 0.876 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 1.208349e-01 0.918 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.217667e-01 0.654 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.217667e-01 0.654 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.217667e-01 0.654 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 2.217667e-01 0.654 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.234880e-01 0.651 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.257146e-01 0.646 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 2.257146e-01 0.646 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.257146e-01 0.646 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.257146e-01 0.646 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.257146e-01 0.646 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.257146e-01 0.646 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.257146e-01 0.646 0 0
Manipulation of host energy metabolism R-HSA-9636667 2.257146e-01 0.646 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.263877e-01 0.645 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.263877e-01 0.645 0 0
G0 and Early G1 R-HSA-1538133 2.263877e-01 0.645 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.292966e-01 0.640 0 0
Antigen processing-Cross presentation R-HSA-1236975 2.302343e-01 0.638 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 2.364915e-01 0.626 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 2.364915e-01 0.626 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.364915e-01 0.626 0 0
Syndecan interactions R-HSA-3000170 2.364915e-01 0.626 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.393246e-01 0.621 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 2.397769e-01 0.620 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 2.414031e-01 0.617 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 2.414031e-01 0.617 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 2.414031e-01 0.617 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 2.414031e-01 0.617 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 2.414031e-01 0.617 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.418793e-01 0.616 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 2.430543e-01 0.614 0 0
HIV Transcription Initiation R-HSA-167161 2.430543e-01 0.614 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 2.430543e-01 0.614 0 0
Translation of Structural Proteins R-HSA-9683701 2.430543e-01 0.614 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.433666e-01 0.614 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.441208e-01 0.612 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.441208e-01 0.612 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 2.441208e-01 0.612 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 2.441208e-01 0.612 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.449309e-01 0.611 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.475257e-01 0.606 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.481269e-01 0.605 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 2.485863e-01 0.605 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.547820e-01 0.594 0 0
Signaling by NTRKs R-HSA-166520 2.566861e-01 0.591 0 0
Cellular response to chemical stress R-HSA-9711123 2.674608e-01 0.573 0 0
Neutrophil degranulation R-HSA-6798695 2.704487e-01 0.568 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 2.712477e-01 0.567 0 0
Lipophagy R-HSA-9613354 2.727649e-01 0.564 0 0
WNT mediated activation of DVL R-HSA-201688 2.727649e-01 0.564 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 2.727649e-01 0.564 0 0
Unwinding of DNA R-HSA-176974 2.727649e-01 0.564 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 2.727649e-01 0.564 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 2.727649e-01 0.564 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.736424e-01 0.563 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 2.736424e-01 0.563 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.742877e-01 0.562 0 0
RMTs methylate histone arginines R-HSA-3214858 2.856333e-01 0.544 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.880103e-01 0.541 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 2.890099e-01 0.539 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 2.890099e-01 0.539 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 2.890099e-01 0.539 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 2.890099e-01 0.539 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.897278e-01 0.538 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.897278e-01 0.538 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.897278e-01 0.538 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 2.897278e-01 0.538 0 0
Signalling to ERKs R-HSA-187687 2.898414e-01 0.538 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.898414e-01 0.538 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.921267e-01 0.534 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 2.921267e-01 0.534 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 2.921267e-01 0.534 0 0
Suppression of phagosomal maturation R-HSA-9637687 2.921267e-01 0.534 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 2.923284e-01 0.534 0 0
Signaling by NOTCH3 R-HSA-9012852 2.937283e-01 0.532 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.953854e-01 0.530 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 3.001778e-01 0.523 0 0
Somitogenesis R-HSA-9824272 3.001778e-01 0.523 0 0
Platelet activation, signaling and aggregation R-HSA-76002 3.033313e-01 0.518 0 0
Translation of Structural Proteins R-HSA-9694635 3.034194e-01 0.518 0 0
Binding and entry of HIV virion R-HSA-173107 3.040711e-01 0.517 0 0
Interleukin-27 signaling R-HSA-9020956 3.040711e-01 0.517 0 0
2-LTR circle formation R-HSA-164843 3.040711e-01 0.517 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.040711e-01 0.517 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 3.062043e-01 0.514 0 0
GPVI-mediated activation cascade R-HSA-114604 3.062043e-01 0.514 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.110692e-01 0.507 0 0
Ephrin signaling R-HSA-3928664 3.127783e-01 0.505 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 3.127783e-01 0.505 0 0
Platelet sensitization by LDL R-HSA-432142 3.127783e-01 0.505 0 0
Polo-like kinase mediated events R-HSA-156711 3.127783e-01 0.505 0 0
RNA Polymerase II Transcription R-HSA-73857 3.190708e-01 0.496 0 0
Gene Silencing by RNA R-HSA-211000 3.196212e-01 0.495 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 3.204501e-01 0.494 0 0
Regulated Necrosis R-HSA-5218859 3.241448e-01 0.489 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.241448e-01 0.489 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.290618e-01 0.483 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.290618e-01 0.483 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.290618e-01 0.483 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.295158e-01 0.482 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 3.301207e-01 0.481 0 0
Signaling by APC mutants R-HSA-4839744 3.351216e-01 0.475 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 3.351216e-01 0.475 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 3.351216e-01 0.475 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 3.351216e-01 0.475 0 0
Formation of the posterior neural plate R-HSA-9832991 3.351216e-01 0.475 0 0
vRNP Assembly R-HSA-192905 3.351216e-01 0.475 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 3.351216e-01 0.475 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 3.358700e-01 0.474 0 0
Germ layer formation at gastrulation R-HSA-9754189 3.358700e-01 0.474 0 0
The NLRP3 inflammasome R-HSA-844456 3.358700e-01 0.474 0 0
STING mediated induction of host immune responses R-HSA-1834941 3.358700e-01 0.474 0 0
Maturation of nucleoprotein R-HSA-9694631 3.358700e-01 0.474 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 3.358700e-01 0.474 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.366604e-01 0.473 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 3.392829e-01 0.469 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 3.394751e-01 0.469 0 0
Gluconeogenesis R-HSA-70263 3.445171e-01 0.463 0 0
MET activates STAT3 R-HSA-8875791 3.471346e-01 0.460 0 0
Axonal growth stimulation R-HSA-209563 3.471346e-01 0.460 0 0
Signalling to STAT3 R-HSA-198745 3.471346e-01 0.460 0 0
MET activates PTPN11 R-HSA-8865999 3.471346e-01 0.460 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 3.471346e-01 0.460 0 0
mRNA Capping R-HSA-72086 3.492303e-01 0.457 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.492303e-01 0.457 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.589190e-01 0.445 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 3.589190e-01 0.445 0 0
Signal transduction by L1 R-HSA-445144 3.589190e-01 0.445 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 3.589190e-01 0.445 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 3.589990e-01 0.445 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 3.657490e-01 0.437 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 3.657490e-01 0.437 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 3.657490e-01 0.437 0 0
Signaling by AMER1 mutants R-HSA-4839748 3.657490e-01 0.437 0 0
Signaling by AXIN mutants R-HSA-4839735 3.657490e-01 0.437 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 3.657490e-01 0.437 0 0
Sodium/Calcium exchangers R-HSA-425561 3.657490e-01 0.437 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.683500e-01 0.434 0 0
Activation of the pre-replicative complex R-HSA-68962 3.683500e-01 0.434 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 3.725973e-01 0.429 0 0
Generation of second messenger molecules R-HSA-202433 3.726088e-01 0.429 0 0
Diseases of Immune System R-HSA-5260271 3.726088e-01 0.429 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 3.726088e-01 0.429 0 0
Glycogen metabolism R-HSA-8982491 3.726088e-01 0.429 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 3.737566e-01 0.427 0 0
MAP kinase activation R-HSA-450294 3.749014e-01 0.426 0 0
Formation of paraxial mesoderm R-HSA-9793380 3.749014e-01 0.426 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 3.798144e-01 0.420 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 3.818489e-01 0.418 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.818489e-01 0.418 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 3.886189e-01 0.410 0 0
DNA Replication R-HSA-69306 3.887509e-01 0.410 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 3.958151e-01 0.403 0 0
Regulation of IFNG signaling R-HSA-877312 3.958151e-01 0.403 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 3.958151e-01 0.403 0 0
Signaling by LTK R-HSA-9842663 3.958151e-01 0.403 0 0
Interleukin-35 Signalling R-HSA-8984722 3.958151e-01 0.403 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.005106e-01 0.397 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.005106e-01 0.397 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.005106e-01 0.397 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.005106e-01 0.397 0 0
Regulation of gap junction activity R-HSA-191650 4.005106e-01 0.397 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 4.005106e-01 0.397 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.005106e-01 0.397 0 0
NADE modulates death signalling R-HSA-205025 4.005106e-01 0.397 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.005106e-01 0.397 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 4.043902e-01 0.393 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 4.043902e-01 0.393 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 4.043902e-01 0.393 0 0
Signaling by WNT in cancer R-HSA-4791275 4.064399e-01 0.391 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 4.064399e-01 0.391 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 4.103954e-01 0.387 0 0
Ion channel transport R-HSA-983712 4.127894e-01 0.384 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.160586e-01 0.381 0 0
Eukaryotic Translation Termination R-HSA-72764 4.176069e-01 0.379 0 0
Amino acids regulate mTORC1 R-HSA-9639288 4.193424e-01 0.377 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 4.225157e-01 0.374 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.252072e-01 0.371 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 4.252072e-01 0.371 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 4.252072e-01 0.371 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 4.252072e-01 0.371 0 0
Formation of axial mesoderm R-HSA-9796292 4.252072e-01 0.371 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 4.252072e-01 0.371 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 4.253270e-01 0.371 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 4.253270e-01 0.371 0 0
Cardiogenesis R-HSA-9733709 4.253270e-01 0.371 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 4.270792e-01 0.369 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 4.270792e-01 0.369 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 4.270792e-01 0.369 0 0
Toll-like Receptor Cascades R-HSA-168898 4.288380e-01 0.368 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.342462e-01 0.362 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 4.353335e-01 0.361 0 0
Response of Mtb to phagocytosis R-HSA-9637690 4.390152e-01 0.358 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 4.413784e-01 0.355 0 0
Resolution of D-Loop Structures R-HSA-5693537 4.440582e-01 0.353 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 4.440582e-01 0.353 0 0
Growth hormone receptor signaling R-HSA-982772 4.492608e-01 0.348 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 4.495257e-01 0.347 0 0
IRS activation R-HSA-74713 4.495257e-01 0.347 0 0
G2 Phase R-HSA-68911 4.495257e-01 0.347 0 0
NTRK2 activates RAC1 R-HSA-9032759 4.495257e-01 0.347 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 4.495257e-01 0.347 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 4.495257e-01 0.347 0 0
PTK6 Activates STAT3 R-HSA-8849474 4.495257e-01 0.347 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 4.495257e-01 0.347 0 0
Activation of AKT2 R-HSA-165158 4.495257e-01 0.347 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 4.495257e-01 0.347 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 4.495257e-01 0.347 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 4.495257e-01 0.347 0 0
Muscarinic acetylcholine receptors R-HSA-390648 4.495257e-01 0.347 0 0
Co-inhibition by BTLA R-HSA-9927353 4.495257e-01 0.347 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 4.495257e-01 0.347 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 4.495257e-01 0.347 0 0
RNA Polymerase I Transcription R-HSA-73864 4.508593e-01 0.346 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.538344e-01 0.343 0 0
Retrograde neurotrophin signalling R-HSA-177504 4.538344e-01 0.343 0 0
Zinc transporters R-HSA-435354 4.538344e-01 0.343 0 0
Gastrulation R-HSA-9758941 4.550113e-01 0.342 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 4.554031e-01 0.342 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.614263e-01 0.336 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.614263e-01 0.336 0 0
FOXO-mediated transcription R-HSA-9614085 4.625667e-01 0.335 0 0
HATs acetylate histones R-HSA-3214847 4.625667e-01 0.335 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 4.625990e-01 0.335 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 4.625990e-01 0.335 0 0
NOD1/2 Signaling Pathway R-HSA-168638 4.625990e-01 0.335 0 0
Signaling by NOTCH2 R-HSA-1980145 4.625990e-01 0.335 0 0
Sensory processing of sound R-HSA-9659379 4.634755e-01 0.334 0 0
NRAGE signals death through JNK R-HSA-193648 4.638314e-01 0.334 0 0
Transmission across Chemical Synapses R-HSA-112315 4.691450e-01 0.329 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 4.705088e-01 0.327 0 0
Deadenylation of mRNA R-HSA-429947 4.710848e-01 0.327 0 0
Complex III assembly R-HSA-9865881 4.710848e-01 0.327 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 4.710848e-01 0.327 0 0
Plasma lipoprotein assembly R-HSA-8963898 4.710848e-01 0.327 0 0
Nucleosome assembly R-HSA-774815 4.716555e-01 0.326 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 4.716555e-01 0.326 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 4.716555e-01 0.326 0 0
Signaling by MET R-HSA-6806834 4.760317e-01 0.322 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.807420e-01 0.318 0 0
PERK regulates gene expression R-HSA-381042 4.809177e-01 0.318 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 4.816255e-01 0.317 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 4.816255e-01 0.317 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 4.816255e-01 0.317 0 0
Formation of the anterior neural plate R-HSA-9823739 4.816255e-01 0.317 0 0
Chromosome Maintenance R-HSA-73886 4.817052e-01 0.317 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 4.877502e-01 0.312 0 0
Amyloid fiber formation R-HSA-977225 4.885168e-01 0.311 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 4.917909e-01 0.308 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 4.917909e-01 0.308 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 4.925077e-01 0.308 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 4.925077e-01 0.308 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.925077e-01 0.308 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 4.925077e-01 0.308 0 0
Plus-strand DNA synthesis R-HSA-164525 4.945360e-01 0.306 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 4.945360e-01 0.306 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 4.945360e-01 0.306 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 4.945360e-01 0.306 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 4.945360e-01 0.306 0 0
PKB-mediated events R-HSA-109703 4.945360e-01 0.306 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 4.945360e-01 0.306 0 0
PDE3B signalling R-HSA-165160 4.945360e-01 0.306 0 0
Cam-PDE 1 activation R-HSA-111957 4.945360e-01 0.306 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 4.945360e-01 0.306 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 4.945360e-01 0.306 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 4.945360e-01 0.306 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 4.945360e-01 0.306 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 4.945360e-01 0.306 0 0
Circadian clock R-HSA-9909396 4.947864e-01 0.306 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 4.959178e-01 0.305 0 0
Interleukin-17 signaling R-HSA-448424 4.972836e-01 0.303 0 0
Triglyceride catabolism R-HSA-163560 4.989853e-01 0.302 0 0
G1/S-Specific Transcription R-HSA-69205 4.989853e-01 0.302 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 5.040939e-01 0.297 0 0
Peroxisomal protein import R-HSA-9033241 5.073867e-01 0.295 0 0
Phosphorylation of the APC/C R-HSA-176412 5.085259e-01 0.294 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.085259e-01 0.294 0 0
Killing mechanisms R-HSA-9664420 5.085259e-01 0.294 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.085259e-01 0.294 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 5.085259e-01 0.294 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 5.085259e-01 0.294 0 0
Virus Assembly and Release R-HSA-168268 5.085259e-01 0.294 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 5.134915e-01 0.289 0 0
Immune System R-HSA-168256 5.151385e-01 0.288 0 0
NGF-stimulated transcription R-HSA-9031628 5.193844e-01 0.285 0 0
Metal ion SLC transporters R-HSA-425410 5.193844e-01 0.285 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 5.216215e-01 0.283 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 5.216215e-01 0.283 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 5.216215e-01 0.283 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 5.216215e-01 0.283 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 5.216215e-01 0.283 0 0
tRNA Aminoacylation R-HSA-379724 5.216215e-01 0.283 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 5.216215e-01 0.283 1 1
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 5.236171e-01 0.281 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 5.302134e-01 0.276 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 5.310868e-01 0.275 0 0
Signaling by FGFR3 in disease R-HSA-5655332 5.340037e-01 0.272 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 5.340037e-01 0.272 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 5.342650e-01 0.272 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 5.344954e-01 0.272 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 5.344954e-01 0.272 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 5.344954e-01 0.272 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 5.344954e-01 0.272 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 5.344954e-01 0.272 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 5.344954e-01 0.272 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 5.344954e-01 0.272 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 5.358684e-01 0.271 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.358684e-01 0.271 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 5.358684e-01 0.271 0 0
Uncoating of the HIV Virion R-HSA-162585 5.358684e-01 0.271 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 5.358684e-01 0.271 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 5.358684e-01 0.271 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 5.358684e-01 0.271 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 5.358684e-01 0.271 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 5.358684e-01 0.271 0 0
G2/M DNA replication checkpoint R-HSA-69478 5.358684e-01 0.271 0 0
Signaling by LTK in cancer R-HSA-9842640 5.358684e-01 0.271 0 0
Ca2+ pathway R-HSA-4086398 5.365890e-01 0.270 0 0
Developmental Cell Lineages R-HSA-9734767 5.384476e-01 0.269 0 0
Interferon alpha/beta signaling R-HSA-909733 5.404726e-01 0.267 0 0
Signaling by FGFR2 in disease R-HSA-5655253 5.501574e-01 0.260 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 5.514325e-01 0.259 0 0
Pentose phosphate pathway R-HSA-71336 5.514325e-01 0.259 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 5.514325e-01 0.259 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 5.514325e-01 0.259 0 0
Telomere Extension By Telomerase R-HSA-171319 5.540167e-01 0.256 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 5.540167e-01 0.256 0 0
Formation of the Early Elongation Complex R-HSA-113418 5.540167e-01 0.256 0 0
Insulin receptor recycling R-HSA-77387 5.540167e-01 0.256 0 0
Inflammasomes R-HSA-622312 5.540167e-01 0.256 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 5.595064e-01 0.252 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 5.595064e-01 0.252 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 5.595064e-01 0.252 0 0
Specification of primordial germ cells R-HSA-9827857 5.595064e-01 0.252 0 0
Mitochondrial biogenesis R-HSA-1592230 5.607481e-01 0.251 0 0
Interleukin-2 family signaling R-HSA-451927 5.682594e-01 0.245 0 0
Signaling by Nuclear Receptors R-HSA-9006931 5.704543e-01 0.244 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 5.707537e-01 0.244 0 0
Pyruvate metabolism R-HSA-70268 5.730752e-01 0.242 0 0
Signaling by Erythropoietin R-HSA-9006335 5.735079e-01 0.241 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 5.735079e-01 0.241 0 0
Platelet calcium homeostasis R-HSA-418360 5.735079e-01 0.241 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 5.738232e-01 0.241 0 0
PTK6 Expression R-HSA-8849473 5.738232e-01 0.241 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 5.738232e-01 0.241 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 5.738232e-01 0.241 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 5.738232e-01 0.241 0 0
VLDL clearance R-HSA-8964046 5.738232e-01 0.241 0 0
CHL1 interactions R-HSA-447041 5.738232e-01 0.241 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 5.738232e-01 0.241 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.746005e-01 0.241 0 0
Signaling by NOTCH1 R-HSA-1980143 5.746005e-01 0.241 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 5.835420e-01 0.234 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 5.835420e-01 0.234 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 5.835420e-01 0.234 0 0
Mismatch Repair R-HSA-5358508 5.835420e-01 0.234 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 5.847297e-01 0.233 0 0
DAP12 signaling R-HSA-2424491 5.924589e-01 0.227 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 5.924589e-01 0.227 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.924589e-01 0.227 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 5.924589e-01 0.227 0 0
Cardiac conduction R-HSA-5576891 5.986621e-01 0.223 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.065946e-01 0.217 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 6.065946e-01 0.217 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.065946e-01 0.217 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.065946e-01 0.217 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.065946e-01 0.217 0 0
Specification of the neural plate border R-HSA-9834899 6.065946e-01 0.217 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.065946e-01 0.217 0 0
Reverse Transcription of HIV RNA R-HSA-162589 6.086763e-01 0.216 0 0
Minus-strand DNA synthesis R-HSA-164516 6.086763e-01 0.216 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 6.086763e-01 0.216 0 0
RSK activation R-HSA-444257 6.086763e-01 0.216 0 0
phospho-PLA2 pathway R-HSA-111995 6.086763e-01 0.216 0 0
MET receptor recycling R-HSA-8875656 6.086763e-01 0.216 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 6.086763e-01 0.216 0 0
Interleukin-23 signaling R-HSA-9020933 6.086763e-01 0.216 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 6.086763e-01 0.216 0 0
Regulation by c-FLIP R-HSA-3371378 6.086763e-01 0.216 0 0
Co-stimulation by ICOS R-HSA-9927354 6.086763e-01 0.216 0 0
Interleukin-9 signaling R-HSA-8985947 6.086763e-01 0.216 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.086763e-01 0.216 0 0
Dimerization of procaspase-8 R-HSA-69416 6.086763e-01 0.216 0 0
Sodium/Proton exchangers R-HSA-425986 6.086763e-01 0.216 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 6.086763e-01 0.216 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 6.091172e-01 0.215 0 0
Inositol phosphate metabolism R-HSA-1483249 6.120879e-01 0.213 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 6.149131e-01 0.211 0 0
Selenocysteine synthesis R-HSA-2408557 6.149131e-01 0.211 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 6.165464e-01 0.210 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 6.165464e-01 0.210 0 0
HDACs deacetylate histones R-HSA-3214815 6.225627e-01 0.206 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 6.286640e-01 0.202 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 6.286640e-01 0.202 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 6.286640e-01 0.202 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 6.286640e-01 0.202 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 6.286640e-01 0.202 0 0
Signaling by NODAL R-HSA-1181150 6.286640e-01 0.202 0 0
DNA strand elongation R-HSA-69190 6.286863e-01 0.202 0 0
TBC/RABGAPs R-HSA-8854214 6.318712e-01 0.199 0 0
Viral mRNA Translation R-HSA-192823 6.355198e-01 0.197 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 6.406810e-01 0.193 0 0
CASP8 activity is inhibited R-HSA-5218900 6.406810e-01 0.193 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 6.406810e-01 0.193 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 6.406810e-01 0.193 0 0
p75NTR regulates axonogenesis R-HSA-193697 6.406810e-01 0.193 0 0
Interleukin-21 signaling R-HSA-9020958 6.406810e-01 0.193 0 0
Regulation of signaling by NODAL R-HSA-1433617 6.406810e-01 0.193 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 6.406810e-01 0.193 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 6.406810e-01 0.193 0 0
Regulated proteolysis of p75NTR R-HSA-193692 6.406810e-01 0.193 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 6.406810e-01 0.193 0 0
Interleukin-1 processing R-HSA-448706 6.406810e-01 0.193 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 6.406810e-01 0.193 0 0
Integrin signaling R-HSA-354192 6.459449e-01 0.190 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 6.459449e-01 0.190 0 0
Proteasome assembly R-HSA-9907900 6.467960e-01 0.189 0 0
Netrin-1 signaling R-HSA-373752 6.467960e-01 0.189 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 6.497569e-01 0.187 0 0
RSV-host interactions R-HSA-9833110 6.555125e-01 0.183 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 6.613146e-01 0.180 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 6.626266e-01 0.179 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 6.698855e-01 0.174 0 0
Mitochondrial calcium ion transport R-HSA-8949215 6.698855e-01 0.174 0 0
Serine metabolism R-HSA-977347 6.698855e-01 0.174 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 6.700700e-01 0.174 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 6.700700e-01 0.174 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 6.700700e-01 0.174 0 0
Receptor Mediated Mitophagy R-HSA-8934903 6.700700e-01 0.174 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 6.700700e-01 0.174 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 6.700700e-01 0.174 0 0
PI3K/AKT activation R-HSA-198203 6.700700e-01 0.174 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 6.700700e-01 0.174 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 6.700700e-01 0.174 0 0
Signaling by Leptin R-HSA-2586552 6.700700e-01 0.174 0 0
Peptide hormone biosynthesis R-HSA-209952 6.700700e-01 0.174 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 6.700700e-01 0.174 0 0
Signal attenuation R-HSA-74749 6.700700e-01 0.174 0 0
Maturation of spike protein R-HSA-9683686 6.700700e-01 0.174 0 0
Disorders of transmembrane transporters R-HSA-5619115 6.743867e-01 0.171 0 0
Extension of Telomeres R-HSA-180786 6.751687e-01 0.171 0 0
Triglyceride metabolism R-HSA-8979227 6.751687e-01 0.171 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 6.754226e-01 0.170 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 6.787301e-01 0.168 0 0
eNOS activation R-HSA-203615 6.787301e-01 0.168 0 0
Notch-HLH transcription pathway R-HSA-350054 6.890662e-01 0.162 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 6.890662e-01 0.162 0 0
LDL clearance R-HSA-8964038 6.890662e-01 0.162 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 6.890662e-01 0.162 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 6.890662e-01 0.162 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 6.891172e-01 0.162 0 0
Transferrin endocytosis and recycling R-HSA-917977 6.942563e-01 0.158 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 6.942563e-01 0.158 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 6.942563e-01 0.158 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 6.962135e-01 0.157 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 6.970568e-01 0.157 0 0
Ionotropic activity of kainate receptors R-HSA-451306 6.970568e-01 0.157 0 0
Synthesis of PI R-HSA-1483226 6.970568e-01 0.157 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 6.970568e-01 0.157 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 6.970568e-01 0.157 0 0
Interleukin-2 signaling R-HSA-9020558 6.970568e-01 0.157 0 0
Dissolution of Fibrin Clot R-HSA-75205 6.970568e-01 0.157 0 0
Protein localization R-HSA-9609507 6.973866e-01 0.157 0 0
Aquaporin-mediated transport R-HSA-445717 6.995661e-01 0.155 0 0
GPER1 signaling R-HSA-9634597 7.023970e-01 0.153 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 7.040034e-01 0.152 0 0
Interleukin receptor SHC signaling R-HSA-912526 7.073195e-01 0.150 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 7.073195e-01 0.150 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.073195e-01 0.150 0 0
PRC2 methylates histones and DNA R-HSA-212300 7.092085e-01 0.149 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 7.112786e-01 0.148 0 0
Heme signaling R-HSA-9707616 7.112786e-01 0.148 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.218376e-01 0.142 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 7.218376e-01 0.142 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 7.218376e-01 0.142 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 7.218376e-01 0.142 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 7.218376e-01 0.142 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 7.246687e-01 0.140 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 7.246687e-01 0.140 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 7.246687e-01 0.140 0 0
FCERI mediated NF-kB activation R-HSA-2871837 7.250922e-01 0.140 0 0
PI3K Cascade R-HSA-109704 7.277134e-01 0.138 0 0
Insulin receptor signalling cascade R-HSA-74751 7.337275e-01 0.134 0 0
The phototransduction cascade R-HSA-2514856 7.397535e-01 0.131 0 0
HCMV Early Events R-HSA-9609690 7.403421e-01 0.131 0 0
G alpha (12/13) signalling events R-HSA-416482 7.404713e-01 0.130 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 7.411396e-01 0.130 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.411396e-01 0.130 0 0
Infectious disease R-HSA-5663205 7.413587e-01 0.130 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 7.445928e-01 0.128 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 7.445928e-01 0.128 0 0
Interleukin-15 signaling R-HSA-8983432 7.445928e-01 0.128 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 7.445928e-01 0.128 0 0
Polymerase switching R-HSA-69091 7.445928e-01 0.128 0 0
Leading Strand Synthesis R-HSA-69109 7.445928e-01 0.128 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 7.445928e-01 0.128 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 7.445928e-01 0.128 0 0
OAS antiviral response R-HSA-8983711 7.445928e-01 0.128 0 0
Neddylation R-HSA-8951664 7.447458e-01 0.128 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 7.506813e-01 0.125 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 7.531902e-01 0.123 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 7.531902e-01 0.123 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 7.531902e-01 0.123 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 7.567597e-01 0.121 0 0
Urea cycle R-HSA-70635 7.567597e-01 0.121 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.634057e-01 0.117 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.634057e-01 0.117 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 7.634057e-01 0.117 0 0
Signaling by Insulin receptor R-HSA-74752 7.650603e-01 0.116 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 7.654877e-01 0.116 0 0
CD28 dependent Vav1 pathway R-HSA-389359 7.654877e-01 0.116 0 0
Processing of SMDT1 R-HSA-8949664 7.654877e-01 0.116 0 0
Interleukin-6 signaling R-HSA-1059683 7.654877e-01 0.116 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 7.654877e-01 0.116 0 0
Maturation of nucleoprotein R-HSA-9683610 7.654877e-01 0.116 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.688580e-01 0.114 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.715580e-01 0.113 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 7.715580e-01 0.113 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 7.735221e-01 0.112 0 0
Hemostasis R-HSA-109582 7.740485e-01 0.111 0 0
Mitochondrial protein degradation R-HSA-9837999 7.817575e-01 0.107 0 0
Generic Transcription Pathway R-HSA-212436 7.819732e-01 0.107 0 0
Removal of the Flap Intermediate R-HSA-69166 7.846743e-01 0.105 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 7.846743e-01 0.105 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 7.846743e-01 0.105 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 7.846743e-01 0.105 0 0
Hydrolysis of LPC R-HSA-1483115 7.846743e-01 0.105 0 0
Physiological factors R-HSA-5578768 7.846743e-01 0.105 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 7.846743e-01 0.105 0 0
Acyl chain remodeling of CL R-HSA-1482798 7.846743e-01 0.105 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 7.872683e-01 0.104 0 0
Scavenging by Class A Receptors R-HSA-3000480 7.872683e-01 0.104 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 7.933585e-01 0.101 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 7.988091e-01 0.098 0 0
Regulation of gene expression in beta cells R-HSA-210745 7.988091e-01 0.098 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 7.988091e-01 0.098 0 0
Stimuli-sensing channels R-HSA-2672351 8.009373e-01 0.096 0 0
Erythropoietin activates RAS R-HSA-9027284 8.022922e-01 0.096 0 0
Processive synthesis on the lagging strand R-HSA-69183 8.022922e-01 0.096 0 0
p38MAPK events R-HSA-171007 8.022922e-01 0.096 0 0
DNA Damage Reversal R-HSA-73942 8.022922e-01 0.096 0 0
IRS-mediated signalling R-HSA-112399 8.036013e-01 0.095 0 0
Post-translational protein modification R-HSA-597592 8.043339e-01 0.095 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 8.113232e-01 0.091 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.113232e-01 0.091 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.113232e-01 0.091 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 8.113232e-01 0.091 0 0
Telomere Maintenance R-HSA-157579 8.124698e-01 0.090 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.129005e-01 0.090 0 0
tRNA processing R-HSA-72306 8.159221e-01 0.088 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 8.184696e-01 0.087 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 8.184696e-01 0.087 0 0
Activation of SMO R-HSA-5635838 8.184696e-01 0.087 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 8.184696e-01 0.087 0 0
Attachment and Entry R-HSA-9678110 8.184696e-01 0.087 0 0
DAP12 interactions R-HSA-2172127 8.192860e-01 0.087 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 8.218359e-01 0.085 0 0
Amino acid transport across the plasma membrane R-HSA-352230 8.218359e-01 0.085 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.231376e-01 0.085 0 0
Downstream signal transduction R-HSA-186763 8.231376e-01 0.085 0 0
Signaling by ERBB4 R-HSA-1236394 8.269409e-01 0.083 0 0
HCMV Infection R-HSA-9609646 8.285246e-01 0.082 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 8.290065e-01 0.081 0 0
Metabolism of polyamines R-HSA-351202 8.304158e-01 0.081 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 8.333242e-01 0.079 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 8.333242e-01 0.079 0 0
Passive transport by Aquaporins R-HSA-432047 8.333242e-01 0.079 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.333242e-01 0.079 0 0
Synthesis of PG R-HSA-1483148 8.333242e-01 0.079 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 8.333242e-01 0.079 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.342829e-01 0.079 0 0
Neuronal System R-HSA-112316 8.348967e-01 0.078 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.369020e-01 0.077 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.382749e-01 0.077 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.382749e-01 0.077 0 0
Diseases of DNA repair R-HSA-9675135 8.382749e-01 0.077 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.386490e-01 0.076 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 8.447894e-01 0.073 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.465444e-01 0.072 0 0
Signaling by PDGF R-HSA-186797 8.465444e-01 0.072 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 8.469640e-01 0.072 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 8.469640e-01 0.072 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 8.469640e-01 0.072 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.469640e-01 0.072 0 0
Uptake and function of anthrax toxins R-HSA-5210891 8.469640e-01 0.072 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.546871e-01 0.068 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.546871e-01 0.068 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.546871e-01 0.068 0 0
Leishmania phagocytosis R-HSA-9664417 8.594747e-01 0.066 0 0
Parasite infection R-HSA-9664407 8.594747e-01 0.066 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.594747e-01 0.066 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 8.594884e-01 0.066 0 0
Tie2 Signaling R-HSA-210993 8.594884e-01 0.066 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 8.594884e-01 0.066 0 0
IGF1R signaling cascade R-HSA-2428924 8.613583e-01 0.065 0 0
Chemokine receptors bind chemokines R-HSA-380108 8.635166e-01 0.064 0 0
Activation of HOX genes during differentiation R-HSA-5619507 8.637315e-01 0.064 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 8.637315e-01 0.064 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 8.640051e-01 0.063 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 8.640051e-01 0.063 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.640051e-01 0.063 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.640051e-01 0.063 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.643834e-01 0.063 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.682954e-01 0.061 0 0
Rab regulation of trafficking R-HSA-9007101 8.684544e-01 0.061 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 8.709884e-01 0.060 0 0
Other interleukin signaling R-HSA-449836 8.709884e-01 0.060 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 8.709884e-01 0.060 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 8.709884e-01 0.060 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 8.709884e-01 0.060 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.727721e-01 0.059 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 8.727721e-01 0.059 0 0
Adipogenesis R-HSA-9843745 8.780611e-01 0.056 0 0
Meiotic recombination R-HSA-912446 8.783573e-01 0.056 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.810157e-01 0.055 0 0
SLC-mediated transport of amino acids R-HSA-9958863 8.812772e-01 0.055 0 0
Acyl chain remodelling of PI R-HSA-1482922 8.815479e-01 0.055 0 0
Creatine metabolism R-HSA-71288 8.815479e-01 0.055 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 8.815479e-01 0.055 0 0
Protein hydroxylation R-HSA-9629569 8.815479e-01 0.055 0 0
Extracellular matrix organization R-HSA-1474244 8.854979e-01 0.053 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 8.887629e-01 0.051 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.887629e-01 0.051 0 0
G-protein activation R-HSA-202040 8.912437e-01 0.050 0 0
Lagging Strand Synthesis R-HSA-69186 8.912437e-01 0.050 0 0
ERK/MAPK targets R-HSA-198753 8.912437e-01 0.050 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 8.912437e-01 0.050 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 8.912437e-01 0.050 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 8.912437e-01 0.050 0 0
Signalling to RAS R-HSA-167044 8.912437e-01 0.050 0 0
Acyl chain remodelling of PG R-HSA-1482925 8.912437e-01 0.050 0 0
Signaling by NOTCH R-HSA-157118 8.914899e-01 0.050 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 8.923775e-01 0.049 0 0
Parasitic Infection Pathways R-HSA-9824443 8.940794e-01 0.049 0 0
Leishmania infection R-HSA-9658195 8.940794e-01 0.049 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 8.960398e-01 0.048 0 0
Elastic fibre formation R-HSA-1566948 8.960398e-01 0.048 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 8.960398e-01 0.048 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 8.966038e-01 0.047 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 9.001464e-01 0.046 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.001464e-01 0.046 0 0
Androgen biosynthesis R-HSA-193048 9.001464e-01 0.046 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.001464e-01 0.046 0 0
Glucocorticoid biosynthesis R-HSA-194002 9.001464e-01 0.046 0 0
Glutathione synthesis and recycling R-HSA-174403 9.001464e-01 0.046 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.001464e-01 0.046 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.001464e-01 0.046 0 0
Attachment and Entry R-HSA-9694614 9.001464e-01 0.046 0 0
Regulation of insulin secretion R-HSA-422356 9.017911e-01 0.045 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.028713e-01 0.044 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.083208e-01 0.042 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.083208e-01 0.042 0 0
Cellular hexose transport R-HSA-189200 9.083208e-01 0.042 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 9.092816e-01 0.041 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.093575e-01 0.041 0 0
Metabolism of proteins R-HSA-392499 9.100447e-01 0.041 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.124125e-01 0.040 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.131828e-01 0.039 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.137608e-01 0.039 0 0
Maturation of spike protein R-HSA-9694548 9.152938e-01 0.038 0 0
SLC transporter disorders R-HSA-5619102 9.157883e-01 0.038 0 0
Interleukin-20 family signaling R-HSA-8854691 9.158264e-01 0.038 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.158264e-01 0.038 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.209302e-01 0.036 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 9.227180e-01 0.035 0 0
Interleukin-6 family signaling R-HSA-6783589 9.227180e-01 0.035 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.227180e-01 0.035 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.227180e-01 0.035 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.227180e-01 0.035 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.227180e-01 0.035 0 0
Neurotransmitter release cycle R-HSA-112310 9.236120e-01 0.035 0 0
Regulation of beta-cell development R-HSA-186712 9.243288e-01 0.034 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.243288e-01 0.034 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.261094e-01 0.033 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.262119e-01 0.033 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 9.274082e-01 0.033 0 0
HCMV Late Events R-HSA-9610379 9.286271e-01 0.032 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.290457e-01 0.032 0 0
Tight junction interactions R-HSA-420029 9.290457e-01 0.032 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.290457e-01 0.032 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 9.290457e-01 0.032 0 0
Formation of the nephric duct R-HSA-9830364 9.290457e-01 0.032 0 0
Laminin interactions R-HSA-3000157 9.290457e-01 0.032 0 0
Defective pyroptosis R-HSA-9710421 9.311592e-01 0.031 0 0
Integrin cell surface interactions R-HSA-216083 9.345084e-01 0.029 0 0
TRP channels R-HSA-3295583 9.348557e-01 0.029 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 9.348557e-01 0.029 0 0
Sphingolipid catabolism R-HSA-9845614 9.348557e-01 0.029 0 0
Platelet homeostasis R-HSA-418346 9.358715e-01 0.029 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.380710e-01 0.028 0 0
Triglyceride biosynthesis R-HSA-75109 9.401902e-01 0.027 0 0
Synthesis of PE R-HSA-1483213 9.401902e-01 0.027 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.401902e-01 0.027 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.401902e-01 0.027 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.407701e-01 0.027 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.409658e-01 0.026 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.450882e-01 0.025 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.450882e-01 0.025 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.450882e-01 0.025 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 9.450882e-01 0.025 0 0
Pyroptosis R-HSA-5620971 9.450882e-01 0.025 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.460957e-01 0.024 0 0
Selenoamino acid metabolism R-HSA-2408522 9.462478e-01 0.024 0 0
Synthesis of PC R-HSA-1483191 9.479777e-01 0.023 0 0
Formation of the cornified envelope R-HSA-6809371 9.485723e-01 0.023 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.495854e-01 0.022 0 0
DNA methylation R-HSA-5334118 9.495854e-01 0.022 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.506243e-01 0.022 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.575056e-01 0.019 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 9.584559e-01 0.018 0 0
COPII-mediated vesicle transport R-HSA-204005 9.618263e-01 0.017 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.641823e-01 0.016 0 0
Nuclear RNA decay R-HSA-9930044 9.641823e-01 0.016 0 0
G-protein beta:gamma signalling R-HSA-397795 9.641823e-01 0.016 0 0
ECM proteoglycans R-HSA-3000178 9.641843e-01 0.016 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.671166e-01 0.015 0 0
Innate Immune System R-HSA-168249 9.675207e-01 0.014 0 0
Signal amplification R-HSA-392518 9.698107e-01 0.013 0 0
G alpha (z) signalling events R-HSA-418597 9.706066e-01 0.013 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.723114e-01 0.012 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.735381e-01 0.012 0 0
Glycosphingolipid transport R-HSA-9845576 9.745551e-01 0.011 0 0
RUNX2 regulates bone development R-HSA-8941326 9.745551e-01 0.011 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.745551e-01 0.011 0 0
Dectin-2 family R-HSA-5621480 9.745658e-01 0.011 0 0
Integration of energy metabolism R-HSA-163685 9.752854e-01 0.011 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.763469e-01 0.010 0 0
NCAM1 interactions R-HSA-419037 9.766401e-01 0.010 0 0
Collagen formation R-HSA-1474290 9.770049e-01 0.010 0 0
Interleukin-10 signaling R-HSA-6783783 9.772244e-01 0.010 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.785544e-01 0.009 0 0
MET promotes cell motility R-HSA-8875878 9.785544e-01 0.009 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.808272e-01 0.008 0 0
Endogenous sterols R-HSA-211976 9.809954e-01 0.008 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 9.819254e-01 0.008 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.819254e-01 0.008 0 0
Mitochondrial protein import R-HSA-1268020 9.823380e-01 0.008 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.823380e-01 0.008 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.825591e-01 0.008 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.825591e-01 0.008 0 0
Interferon gamma signaling R-HSA-877300 9.833627e-01 0.007 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.834069e-01 0.007 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 9.834069e-01 0.007 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.834069e-01 0.007 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.847522e-01 0.007 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.847669e-01 0.007 0 0
Surfactant metabolism R-HSA-5683826 9.882145e-01 0.005 0 0
Amine ligand-binding receptors R-HSA-375280 9.882145e-01 0.005 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.882145e-01 0.005 0 0
Disease R-HSA-1643685 9.888004e-01 0.005 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.895611e-01 0.005 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.902230e-01 0.004 0 0
Metabolism of cofactors R-HSA-8978934 9.909252e-01 0.004 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.910148e-01 0.004 0 0
G alpha (s) signalling events R-HSA-418555 9.914227e-01 0.004 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.916299e-01 0.004 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.923734e-01 0.003 0 0
FCGR activation R-HSA-2029481 9.927094e-01 0.003 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.927490e-01 0.003 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.929464e-01 0.003 0 0
Complex IV assembly R-HSA-9864848 9.935249e-01 0.003 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.935249e-01 0.003 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.942125e-01 0.003 0 0
Peptide hormone metabolism R-HSA-2980736 9.957831e-01 0.002 0 0
Synthesis of PA R-HSA-1483166 9.961255e-01 0.002 0 0
PPARA activates gene expression R-HSA-1989781 9.968009e-01 0.001 0 0
Glutathione conjugation R-HSA-156590 9.970032e-01 0.001 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.970032e-01 0.001 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.971597e-01 0.001 0 0
Collagen degradation R-HSA-1442490 9.972491e-01 0.001 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.972891e-01 0.001 0 0
Transport of small molecules R-HSA-382551 9.973619e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.976821e-01 0.001 0 0
Xenobiotics R-HSA-211981 9.978724e-01 0.001 0 0
G alpha (i) signalling events R-HSA-418594 9.980843e-01 0.001 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.982073e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.983545e-01 0.001 0 0
Kidney development R-HSA-9830369 9.983545e-01 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.984896e-01 0.001 0 0
Peptide ligand-binding receptors R-HSA-375276 9.985819e-01 0.001 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.986360e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.988242e-01 0.001 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.988336e-01 0.001 0 0
Aspirin ADME R-HSA-9749641 9.990159e-01 0.000 0 0
PI Metabolism R-HSA-1483255 9.993233e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.993589e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.993739e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.994209e-01 0.000 1 0
Visual phototransduction R-HSA-2187338 9.995712e-01 0.000 0 0
Keratinization R-HSA-6805567 9.995982e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.996167e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.997042e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.997135e-01 0.000 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.997352e-01 0.000 0 0
Base Excision Repair R-HSA-73884 9.997897e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.998067e-01 0.000 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.998070e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.998494e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.998942e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999011e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999109e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999182e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999312e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999423e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999552e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999636e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999682e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999708e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999755e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999950e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999956e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.999978e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999987e-01 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 9.999989e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999990e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999998e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 1 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 1 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways