PIM2

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0MZ66 T487 Sugiyama SHTN1 KIAA1598 sLDPENsEtELERILRRRKVtAEADsssPtGILAtsEsKsM
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
A5A3E0 Y940 Sugiyama POTEF A26C1B ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
O00571 S594 Sugiyama DDX3X DBX DDX3 MAyEHHyKGssRGRSKssRFsGGFGARDYRQssGAssssFs
O14617 S658 Sugiyama AP3D1 PRO0039 DERPRAVFHEEEQRRPKHRPsEADEEELARRREARKQEQAN
O43524 S253 SIGNOR FOXO3 FKHRL1 FOXO3A WWIINPDGGKsGKAPRRRAVsMDNsNKYTKSRGRAAKKKAA
O43524 T32 SIGNOR FOXO3 FKHRL1 FOXO3A sPLEVELDPEFEPQSRPRsCtWPLQRPELQAsPAKPSGETA
O60271 S183 Sugiyama SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6 HTEMIHNYMEHLERTKLHQLsGsDQLEstAHsRIRKERPIs
O60814 S37 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
O60814 Y38 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK AVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
O60841 S182 Sugiyama EIF5B IF2 KIAA0741 DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O60841 S183 Sugiyama EIF5B IF2 KIAA0741 GsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKN
O94761 S27 Sugiyama RECQL4 RECQ4 VRERLQAWERAFRRQRGRRPsQDDVEAAPEETRALYREYRT
P00338 S161 PSP|Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00338 S319 PSP LDHA PIG19 GISDLVKVTLtsEEEARLKKsADtLWGIQKELQF_______
P00558 S393 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 GGDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDA
P00558 T394 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 GDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDAL
P01106 S308 PSP MYC BHLHE39 PGKRSESGSPSAGGHSKPPHsPLVLKRCHVSTHQHNYAAPP
P04040 T29 Sugiyama CAT SDQMQHWKEQRAAQKADVLttGAGNPVGDKLNVItVGPRGP
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P06733 Y44 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07205 S393 Sugiyama PGK2 PGKB GGDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEA
P07205 T394 Sugiyama PGK2 PGKB GDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEAL
P07437 T55 Sugiyama TUBB TUBB5 OK/SW-cl.56 tyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEPGtMDs
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900 S63 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPN
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 S58 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPN
P08238 T459 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB LGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEt
P09467 S144 PSP FBP1 FBP SSNIDCLVSVGTIFGIYRKKsTDEPSEKDALQPGRNLVAAG
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P10412 S36 Sugiyama H1-4 H1F4 HIST1H1E EKtPVKKKARKsAGAAKRKAsGPPVsELItKAVAASKERsG
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P12277 S129 Sugiyama CKB CKBB DLNPDNLQGGDDLDPNyVLssRVRTGRSIRGFCLPPHCsRG
P12277 T327 Sugiyama CKB CKBB KFsEVLKRLRLQKRGtGGVDtAAVGGVFDVsNADRLGFSEV
P13639 S593 Sugiyama EEF2 EF2 SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14618 T454 SIGNOR|EPSD|PSP PKM OIP3 PK2 PK3 PKM2 SGRSAHQVARYRPRAPIIAVtRNPQtARQAHLYRGIFPVLC
P14625 S514 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK
P14625 S64 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 tDDEVVQREEEAIQLDGLNAsQIRELREKSEKFAFQAEVNR
P14625 T519 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 DHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQDKIy
P16402 S37 Sugiyama H1-3 H1F3 HIST1H1D KtPVKKKAKKAGATAGKRKAsGPPVsELItKAVAASKERsG
P16403 S36 Sugiyama H1-2 H1F2 HIST1H1C EKAPVKKKAAKKAGGtPRKAsGPPVsELItKAVAASKERsG
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P21333 S1301 Sugiyama FLNA FLN FLN1 DARALtQtGGPHVKARVANPsGNLTEtyVQDRGDGMYKVEy
P22059 S190 Sugiyama OSBP OSBP1 QRWVTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNT
P22626 S225 Sugiyama HNRNPA2B1 HNRPA2B1 GNFGFGDsRGGGGNFGPGPGsNFRGGsDGyGsGRGFGDGyN
P22626 Y347 Sugiyama HNRNPA2B1 HNRPA2B1 MGGPyGGGNyGPGGsGGsGGyGGRsRy______________
P23588 S406 Sugiyama EIF4B KLQRQLDEPKLERRPRERHPsWRsEEtQERERsRtGsEssQ
P26373 T107 Sugiyama RPL13 BBC1 OK/SW-cl.46 HKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILF
P27448 S96 SIGNOR MARK3 CTAK1 EMK2 ILTGREVAIKIIDKtQLNPtsLQKLFREVRIMKILNHPNIV
P27448 T90 SIGNOR MARK3 CTAK1 EMK2 VKLARHILTGREVAIKIIDKtQLNPtsLQKLFREVRIMKIL
P27448 T95 SIGNOR MARK3 CTAK1 EMK2 HILTGREVAIKIIDKtQLNPtsLQKLFREVRIMKILNHPNI
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P30043 S202 Sugiyama BLVRB FLR SCAN GHFMLRCLttDEyDGHstyPsHQyQ________________
P30533 S242 Sugiyama LRPAP1 A2MRAP TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P33316 S120 Sugiyama DUT PsKRARPAEVGGMQLRFARLsEHAtAPTRGsARAAGYDLYS
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P35568 S1101 EPSD|PSP IRS1 RNQSAKVIRADPQGCRRRHssEtFsstPSATRVGNTVPFGA
P35613 S279 Sugiyama BSG UNQ6505/PRO21383 TDSEDKALMNGSESRFFVsssQGRSELHIENLNMEADPGQy
P36578 S87 Sugiyama RPL4 RPL1 WGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAPTKT
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37837 S13 Sugiyama TALDO1 TAL TALDO TALDOR ________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P38646 S212 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 tVPAyFNDsQRQAtKDAGQIsGLNVLRVINEPTAAALAyGL
P38936 S146 EPSD|PSP CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1 QAEGsPGGPGDSQGRKRRQtsMTDFYHsKRRLIFSKRKP__
P38936 T145 GPS6|SIGNOR|EPSD|PSP CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1 EQAEGsPGGPGDSQGRKRRQtsMTDFYHsKRRLIFSKRKP_
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P42677 S78 Sugiyama RPS27 MPS1 GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46013 S299 Sugiyama MKI67 GLQGETQLLVSRKSRPKsGGsGHAVAEPAsPEQELDQNKGK
P46527 T157 SIGNOR CDKN1B KIP1 p27 PsDsQTGLAEQCAGIRKRPAtDDSSTQNKRANRTEENVsDG
P46527 T198 SIGNOR CDKN1B KIP1 p27 sPNAGSVEQtPKKPGLRRRQt____________________
P46776 T95 Sugiyama RPL27A LDKLWtLVsEQtRVNAAKNKtGAAPIIDVVRsGyyKVLGKG
P46777 S176 Sugiyama RPL5 MSTP030 GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49321 S659 Sugiyama NASP IEELKELLPEIREKIEDAKEsQRsGNVAELALKATLVEsst
P49327 S1997 Sugiyama FASN FAS DGLLENQTPEFFQDVCKPKYsGtLNLDRVTREACPELDYFV
P49327 T1999 Sugiyama FASN FAS LLENQTPEFFQDVCKPKYsGtLNLDRVTREACPELDYFVVF
P49419 S84 Sugiyama ALDH7A1 ATQ1 EVIttyCPANNEPIARVRQAsVADyEEtVKKAREAWKIWAD
P50990 S23 Sugiyama CCT8 C21orf112 CCTQ KIAA0002 LHVPKAPGFAQMLKEGAKHFsGLEEAVyRNIQACKELAQTT
P51692 S731 PSP STAT5B FVNASADAGGGSATyMDQAPsPAVCPQAHyNMyPQNPDSVL
P52789 T473 PSP HK2 AAMVTAVAYRLADQHRARQKtLEHLQLSHDQLLEVKRRMKV
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P57053 S37 Sugiyama H2BC12L H2BFS H2BS1 KAVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIss
P57053 Y38 Sugiyama H2BC12L H2BFS H2BS1 AVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssK
P57721 T159 Sugiyama PCBP3 PCBP3-OT1 PCBP3OT sQCGsLIGKGGSKIKEIREstGAQVQVAGDMLPNstERAVT
P58876 S37 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
P58876 Y38 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD AVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
P60174 T214 Sugiyama TPI1 TPI KsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGG
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 Y240 Sugiyama ACTB ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P60983 T27 Sugiyama GMFB VCDVAEDLVEKLRKFRFRKEtNNAAIIMKIDKDKRLVVLDE
P61254 S31 Sugiyama RPL26 RsKNRKRHFNAPsHIRRKIMssPLSKELRQKYNVRSMPIRK
P61978 S401 Sugiyama HNRNPK HNRPK GDLGGPIIttQVtIPKDLAGsIIGKGGQRIKQIRHEsGAsI
P61978 S417 Sugiyama HNRNPK HNRPK DLAGsIIGKGGQRIKQIRHEsGAsIKIDEPLEGsEDRIITI
P61978 S420 Sugiyama HNRNPK HNRPK GsIIGKGGQRIKQIRHEsGAsIKIDEPLEGsEDRIITItGt
P62263 S137 Sugiyama RPS14 PRO2640 RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62736 Y242 Sugiyama ACTA2 ACTSA ACTVS GIG46 ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62807 S37 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI KAVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIss
P62807 Y38 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI AVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssK
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 Y240 Sugiyama ACTG1 ACTG ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63267 Y241 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P67809 S136 Sugiyama YBX1 NSEP1 YB1 GEKGAEAANVtGPGGVPVQGsKYAADRNHYRRYPRRRGPPR
P68032 Y242 Sugiyama ACTC1 ACTC ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68104 T432 Sugiyama EEF1A1 EEF1A EF1A LENG7 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133 Y242 Sugiyama ACTA1 ACTA ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68431 S11 SIGNOR H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J __________MARtKQtARKstGGKAPRKQLATKAARKsAP
P78362 S494 Sugiyama SRPK2 GSPLTEQEESSPSHDRSRtVsAsstGDLPKAKTRAADLLVN
Q00613 T120 PSP HSF1 HSTF1 QHPCFLRGQEQLLENIKRKVtsVSTLKSEDIKIRQDSVTKL
Q00987 S166 SIGNOR MDM2 KPSSSHLVSRPstSSRRRAIsEtEENsDELsGERQRKRHKs
Q00987 S186 SIGNOR MDM2 sEtEENsDELsGERQRKRHKsDsISLsFDESLALCVIREIC
Q01105 S161 Sugiyama SET FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q02543 S123 Sugiyama RPL18A AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK
Q02543 T168 Sugiyama RPL18A SKIKFPLPHRVLRRQHKPRFttKRPNtFF____________
Q02543 T169 Sugiyama RPL18A KIKFPLPHRVLRRQHKPRFttKRPNtFF_____________
Q02543 T174 Sugiyama RPL18A LPHRVLRRQHKPRFttKRPNtFF__________________
Q04206 S276 SIGNOR RELA NFKB3 PYADPsLQAPVRVsMQLRRPsDRELsEPMEFQYLPDTDDRH
Q05639 T432 Sugiyama EEF1A2 EEF1AL STN VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q08945 S657 Sugiyama SSRP1 FACT80 MEKKSTPSRGsSSKSsSRQLsEsFKSKEFVssDEsssGENK
Q13131 S467 SIGNOR|PSP PRKAA1 AMPK1 RKNPVTSTYSKMSLQLYQVDsRTYLLDFRsIDDEItEAKsG
Q13200 S361 SIGNOR|PSP PSMD2 TRAP2 EPKVPDDIyKtHLENNRFGGsGsQVDSARMNLASSFVNGFV
Q13247 S301 Sugiyama SRSF6 SFRS6 SRP55 PKENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKR
Q13442 S19 Sugiyama PDAP1 HASPP28 __MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEEE
Q13442 Y17 Sugiyama PDAP1 HASPP28 ____MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREE
Q14152 S584 Sugiyama EIF3A EIF3S10 KIAA0139 EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14432 S294 Sugiyama PDE3A QLIAGTKEDIPVFKRRRRsssVVsAEMSGCSSKSHRRtsLP
Q15293 Y278 Sugiyama RCN1 RCN LNKDGKLDKDEIRHWILPQDyDHAQAEARHLVyESDKNKDE
Q15365 T127 Sugiyama PCBP1 TQCGsLIGKGGCKIKEIREstGAQVQVAGDMLPNstERAIT
Q15366 T127 Sugiyama PCBP2 sQCGsLIGKGGCKIKEIREstGAQVQVAGDMLPNstERAIT
Q16875 S478 SIGNOR|PSP PFKFB3 RRNsVtPLAsPEPtKKPRINsFEEHVASTSAALPSCLPPEV
Q16877 T140 PSP PFKFB4 EEGGHVAVFDATNTTRERRAtIFNFGEQNGYKTFFVESICV
Q562R1 Y241 Sugiyama ACTBL2 ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q58FF6 S34 Sugiyama HSP90AB4P IFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDIIPN
Q58FF7 S58 Sugiyama HSP90AB3P HSP90BC IFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FF8 S58 Sugiyama HSP90AB2P HSP90BB IFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q5QNW6 S37 Sugiyama H2BC18 HIST2H2BF KAVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q5QNW6 Y38 Sugiyama H2BC18 HIST2H2BF AVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
Q5T0N5 S489 Sugiyama FNBP1L C1orf39 TOCA1 EAWLSEVEGKTGGRGDRRHssDINHLVtQGREsPEGsytDD
Q5T5C0 S692 Sugiyama STXBP5 LLGL3 YGSNDPYRREPRSPRKsRQPsGAGLCDIsEGtVVPEDRCKS
Q5VTE0 T432 Sugiyama EEF1A1P5 EEF1AL3 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q6PKG0 S823 Sugiyama LARP1 KIAA0731 LARP VVKEGRTLDAKMPRKRKtRHssNPPLEsHVGWVMDSREHRP
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6S8J3 Y940 Sugiyama POTEE A26C1A POTE2 ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q71UM5 S78 Sugiyama RPS27L GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q8N1G4 T27 Sugiyama LRRC47 KIAA1185 SESWPELELAERERRRELLLtGPGLEERVRAAGGQLPPRLF
Q8WUX9 T408 Sugiyama CHMP7 LQDTTKEPLDLPDNPRNRHFtNsVPNPRIsDAELEAELEKL
Q92597 S330 Sugiyama NDRG1 CAP43 DRG1 RTP QGMGYMPsAsMtRLMRsRtAsGssVtsLDGtRsRsHtSEGT
Q92934 S118 SIGNOR|iPTMNet|EPSD BAD BBC6 BCL2L8 RsAPPNLWAAQRYGRELRRMsDEFVDsFKKGLPRPKsAGtA
Q92934 S75 SIGNOR|iPTMNet|EPSD BAD BBC6 BCL2L8 PTSSSHHGGAGAVEIRsRHssyPAGtEDDEGMGEEPsPFRG
Q92934 S99 SIGNOR|iPTMNet|EPSD BAD BBC6 BCL2L8 GtEDDEGMGEEPsPFRGRsRsAPPNLWAAQRYGRELRRMsD
Q93079 S37 Sugiyama H2BC9 H2BFJ HIST1H2BH KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q93079 Y38 Sugiyama H2BC9 H2BFJ HIST1H2BH AVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
Q99683 S83 SIGNOR MAP3K5 ASK1 MAPKKK5 MEKK5 PGIGCPAATSSSSATRGRGSsVGGGSRRTTVAYVINEASQG
Q99877 S37 Sugiyama H2BC15 H2BFD HIST1H2BN KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99877 Y38 Sugiyama H2BC15 H2BFD HIST1H2BN AVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
Q99879 S37 Sugiyama H2BC14 H2BFE HIST1H2BM KAINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99879 Y38 Sugiyama H2BC14 H2BFE HIST1H2BM AINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
Q99880 S37 Sugiyama H2BC13 H2BFC HIST1H2BL KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99880 Y38 Sugiyama H2BC13 H2BFC HIST1H2BL AVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9BYX7 Y240 Sugiyama POTEKP ACTBL3 FKSG30 ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9H0K1 S358 Sugiyama SIK2 KIAA0781 QIK SNF1LK2 KSHRssFPVEQRLDGRQRRPstIAEQtVAKAQtVGLPVTMH
Q9NYV4 S1053 Sugiyama CDK12 CRK7 CRKRS KIAA0904 LPHWQDCHELWSKKRRRQRQsGVVVEEPPPSKTSRKETtsG
Q9NZN8 S242 Sugiyama CNOT2 CDC36 NOT2 HSPC131 MSTP046 VTGLDLSDFPALADRNRREGsGNPtPLINPLAGRAPYVGMV
Q9UBR2 S78 Sugiyama CTSZ SPADLPKSWDWRNVDGVNyAsItRNQHIPQYCGSCWAHAST
Q9UGV2 S331 Sugiyama NDRG3 QGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQ
Q9UNN5 S582 Sugiyama FAF1 UBXD12 UBXN3A CGI-03 PPEPKEENAEPVSKLRIRtPsGEFLERRFLASNKLQIVFDF
Q9UNX3 S31 Sugiyama RPL26L1 RPL26P1 RsKNRKRHFNAPSHVRRKIMssPLSKELRQKYNVRSMPIRK
Q9Y697 S283 Sugiyama NFS1 NIFS HUSSY-08 KGVGAIYIRRRPRVRVEALQsGGGQERGMRsGTVPTPLVVG
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Gene expression (Transcription) R-HSA-74160 4.116301e-09 8.385 0 0
RNA Polymerase II Transcription R-HSA-73857 4.785650e-09 8.320 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.417527e-08 7.848 0 0
PKMTs methylate histone lysines R-HSA-3214841 3.288158e-07 6.483 0 0
Chromatin modifying enzymes R-HSA-3247509 9.609150e-07 6.017 0 0
Generic Transcription Pathway R-HSA-212436 9.180758e-07 6.037 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.114429e-06 5.953 0 0
Axon guidance R-HSA-422475 1.312914e-06 5.882 0 0
Chromatin organization R-HSA-4839726 2.014012e-06 5.696 0 0
NRAGE signals death through JNK R-HSA-193648 1.963307e-06 5.707 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.321459e-06 5.634 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.323008e-06 5.634 0 0
Apoptotic execution phase R-HSA-75153 2.596522e-06 5.586 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 3.131002e-06 5.504 0 0
G alpha (12/13) signalling events R-HSA-416482 4.030834e-06 5.395 0 0
Signal Transduction R-HSA-162582 6.948212e-06 5.158 0 0
mRNA Splicing - Major Pathway R-HSA-72163 7.978343e-06 5.098 0 0
Nervous system development R-HSA-9675108 7.797097e-06 5.108 0 0
Cell Cycle R-HSA-1640170 1.374184e-05 4.862 0 0
mRNA 3'-end processing R-HSA-72187 1.505811e-05 4.822 0 0
mRNA Splicing R-HSA-72172 1.829410e-05 4.738 0 0
Regulation of TP53 Activity R-HSA-5633007 2.155014e-05 4.667 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 4.277908e-05 4.369 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 5.362142e-05 4.271 0 0
Cellular Senescence R-HSA-2559583 5.446400e-05 4.264 0 0
Cell Cycle Checkpoints R-HSA-69620 5.808191e-05 4.236 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 6.351853e-05 4.197 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.242083e-04 3.906 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.670320e-04 3.777 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.719207e-04 3.765 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.949496e-04 3.710 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.075488e-04 3.683 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.314872e-04 3.635 0 0
Death Receptor Signaling R-HSA-73887 2.321865e-04 3.634 0 0
Signaling by ROBO receptors R-HSA-376176 2.588809e-04 3.587 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.660998e-04 3.575 0 0
Cell Cycle, Mitotic R-HSA-69278 2.643686e-04 3.578 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.873704e-04 3.542 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 3.108325e-04 3.507 0 0
Sema4D in semaphorin signaling R-HSA-400685 4.884656e-04 3.311 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 6.054517e-04 3.218 0 0
Intracellular signaling by second messengers R-HSA-9006925 6.831530e-04 3.165 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 8.141431e-04 3.089 0 0
Specification of primordial germ cells R-HSA-9827857 8.473312e-04 3.072 0 0
EPH-Ephrin signaling R-HSA-2682334 9.650191e-04 3.015 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.190530e-03 2.924 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.205680e-03 2.919 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.392932e-03 2.856 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.430060e-03 2.845 0 0
Germ layer formation at gastrulation R-HSA-9754189 1.673976e-03 2.776 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.689328e-03 2.772 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.767311e-03 2.753 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.775174e-03 2.751 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.939545e-03 2.712 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.031449e-03 2.692 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.285164e-03 2.641 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.308666e-03 2.637 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.308666e-03 2.637 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.496487e-03 2.603 0 0
Signaling by Hippo R-HSA-2028269 2.821665e-03 2.549 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 3.125284e-03 2.505 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 3.125284e-03 2.505 0 0
Signaling by VEGF R-HSA-194138 3.103705e-03 2.508 0 0
Metabolism of RNA R-HSA-8953854 3.418788e-03 2.466 0 0
Regulation of TP53 Expression R-HSA-6804754 3.816370e-03 2.418 0 0
RET signaling R-HSA-8853659 3.793579e-03 2.421 0 0
Polo-like kinase mediated events R-HSA-156711 3.840006e-03 2.416 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.878134e-03 2.411 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 4.047372e-03 2.393 0 0
HDMs demethylate histones R-HSA-3214842 4.111059e-03 2.386 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 4.219553e-03 2.375 0 0
Semaphorin interactions R-HSA-373755 4.808683e-03 2.318 0 0
Apoptosis R-HSA-109581 4.845527e-03 2.315 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 5.055914e-03 2.296 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 5.865258e-03 2.232 0 0
Mitotic Spindle Checkpoint R-HSA-69618 5.968943e-03 2.224 0 0
Programmed Cell Death R-HSA-5357801 6.239589e-03 2.205 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 8.322793e-03 2.080 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 8.322793e-03 2.080 0 0
Regulation of TP53 Degradation R-HSA-6804757 8.893354e-03 2.051 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 8.959213e-03 2.048 0 0
EPHB-mediated forward signaling R-HSA-3928662 8.990588e-03 2.046 0 0
Activation of RAC1 R-HSA-428540 1.005258e-02 1.998 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 9.854281e-03 2.006 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 9.817724e-03 2.008 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.049605e-02 1.979 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.073581e-02 1.969 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.122246e-02 1.950 0 0
Peptide chain elongation R-HSA-156902 1.174506e-02 1.930 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.174979e-02 1.930 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.271876e-02 1.896 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.235623e-02 1.908 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.280157e-02 1.893 0 0
ESR-mediated signaling R-HSA-8939211 1.333175e-02 1.875 0 0
Ion homeostasis R-HSA-5578775 1.359938e-02 1.866 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.508508e-02 1.821 0 0
Rap1 signalling R-HSA-392517 1.439987e-02 1.842 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 1.517098e-02 1.819 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 1.517098e-02 1.819 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.598619e-02 1.796 0 0
TBC/RABGAPs R-HSA-8854214 1.605747e-02 1.794 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.736696e-02 1.760 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.681100e-02 1.774 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.661737e-02 1.779 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.786906e-02 1.748 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.802303e-02 1.744 0 0
G0 and Early G1 R-HSA-1538133 1.809067e-02 1.743 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.809067e-02 1.743 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.818301e-02 1.740 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.964103e-02 1.707 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 2.537774e-02 1.596 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 2.537774e-02 1.596 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 2.537774e-02 1.596 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 2.537774e-02 1.596 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 2.537774e-02 1.596 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 2.537774e-02 1.596 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 2.537774e-02 1.596 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 2.537774e-02 1.596 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 2.537774e-02 1.596 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 2.537774e-02 1.596 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 2.537774e-02 1.596 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 2.537774e-02 1.596 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.493341e-02 1.603 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.493341e-02 1.603 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.493341e-02 1.603 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.493341e-02 1.603 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.385419e-02 1.622 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.302839e-02 1.638 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.555466e-02 1.593 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.155651e-02 1.666 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.493341e-02 1.603 0 0
G2/M Transition R-HSA-69275 2.351648e-02 1.629 0 0
Signaling by Interleukins R-HSA-449147 2.339880e-02 1.631 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 2.689568e-02 1.570 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 2.771600e-02 1.557 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.794586e-02 1.554 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.944128e-02 1.531 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.032404e-02 1.518 0 0
DCC mediated attractive signaling R-HSA-418885 3.129296e-02 1.505 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 3.129296e-02 1.505 0 0
Nuclear Receptor transcription pathway R-HSA-383280 3.213225e-02 1.493 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.285241e-02 1.483 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.388343e-02 1.470 0 0
G2/M DNA damage checkpoint R-HSA-69473 3.614521e-02 1.442 0 0
Netrin-1 signaling R-HSA-373752 3.674866e-02 1.435 0 0
Oncogene Induced Senescence R-HSA-2559585 3.489004e-02 1.457 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.945851e-02 1.404 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.945851e-02 1.404 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.945851e-02 1.404 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.945851e-02 1.404 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.945851e-02 1.404 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.776264e-02 1.423 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 3.776264e-02 1.423 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 3.776264e-02 1.423 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 3.776264e-02 1.423 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 3.776264e-02 1.423 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 4.044334e-02 1.393 0 0
Epigenetic regulation of gene expression R-HSA-212165 3.832335e-02 1.417 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 3.776264e-02 1.423 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.069351e-02 1.390 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 4.124963e-02 1.385 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 4.127194e-02 1.384 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 4.127194e-02 1.384 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.127194e-02 1.384 0 0
Signaling by LTK R-HSA-9842663 4.127194e-02 1.384 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 4.133268e-02 1.384 0 0
Integrin signaling R-HSA-354192 4.534401e-02 1.343 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 4.404348e-02 1.356 0 0
HATs acetylate histones R-HSA-3214847 4.283837e-02 1.368 0 0
Signaling by ERBB2 R-HSA-1227986 4.168097e-02 1.380 0 0
G2/M Checkpoints R-HSA-69481 4.177765e-02 1.379 0 0
Cardiogenesis R-HSA-9733709 4.534401e-02 1.343 0 0
Signaling by WNT R-HSA-195721 4.603992e-02 1.337 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 4.430146e-02 1.354 0 0
Nuclear RNA decay R-HSA-9930044 4.534401e-02 1.343 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 4.451895e-02 1.351 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 4.168097e-02 1.380 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.184055e-02 1.378 0 0
Cellular responses to stimuli R-HSA-8953897 4.651299e-02 1.332 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 4.702050e-02 1.328 0 0
Cellular responses to stress R-HSA-2262752 4.732988e-02 1.325 0 0
Eukaryotic Translation Termination R-HSA-72764 4.801399e-02 1.319 0 0
SARS-CoV-1 Infection R-HSA-9678108 4.885888e-02 1.311 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 4.981313e-02 1.303 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 5.172825e-02 1.286 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 5.236549e-02 1.281 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.236549e-02 1.281 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.236549e-02 1.281 0 0
Signal attenuation R-HSA-74749 5.468768e-02 1.262 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 5.583855e-02 1.253 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 5.708210e-02 1.244 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 5.374345e-02 1.270 0 0
M Phase R-HSA-68886 5.430198e-02 1.265 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 5.944955e-02 1.226 0 0
Mitotic Anaphase R-HSA-68882 5.633089e-02 1.249 0 0
MTOR signalling R-HSA-165159 5.355403e-02 1.271 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 5.905433e-02 1.229 0 0
Eukaryotic Translation Initiation R-HSA-72613 5.783715e-02 1.238 0 0
Cap-dependent Translation Initiation R-HSA-72737 5.783715e-02 1.238 0 0
Reproduction R-HSA-1474165 5.583146e-02 1.253 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 5.468768e-02 1.262 0 0
Sensory processing of sound R-HSA-9659379 5.869951e-02 1.231 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 6.006116e-02 1.221 0 0
RAF activation R-HSA-5673000 6.014877e-02 1.221 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.014877e-02 1.221 0 0
Rab regulation of trafficking R-HSA-9007101 6.220087e-02 1.206 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 6.477453e-02 1.189 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 6.510918e-02 1.186 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 6.645080e-02 1.177 0 0
TRP channels R-HSA-3295583 6.659845e-02 1.177 0 0
MTF1 activates gene expression R-HSA-5660489 6.849188e-02 1.164 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 6.849188e-02 1.164 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 6.849188e-02 1.164 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 7.283785e-02 1.138 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 7.283785e-02 1.138 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 7.283785e-02 1.138 0 0
Regulation of PTEN localization R-HSA-8948747 7.283785e-02 1.138 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 7.283785e-02 1.138 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 7.143698e-02 1.146 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 7.143698e-02 1.146 0 0
Ephrin signaling R-HSA-3928664 7.143698e-02 1.146 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 7.513723e-02 1.124 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 7.709637e-02 1.113 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 7.709637e-02 1.113 0 0
Regulation of PTEN gene transcription R-HSA-8943724 7.158149e-02 1.145 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 7.091803e-02 1.149 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 7.709637e-02 1.113 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 7.143698e-02 1.146 0 0
Dopamine receptors R-HSA-390651 6.849188e-02 1.164 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 7.709637e-02 1.113 0 0
Signaling by NTRKs R-HSA-166520 6.932206e-02 1.159 0 0
MECP2 regulates transcription factors R-HSA-9022707 7.283785e-02 1.138 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 6.837669e-02 1.165 0 0
RAB geranylgeranylation R-HSA-8873719 7.158149e-02 1.145 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.143698e-02 1.146 0 0
Selenocysteine synthesis R-HSA-2408557 7.738159e-02 1.111 0 0
RNA Polymerase III Transcription R-HSA-74158 7.781974e-02 1.109 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 7.781974e-02 1.109 0 0
Calmodulin induced events R-HSA-111933 7.781974e-02 1.109 0 0
CaM pathway R-HSA-111997 7.781974e-02 1.109 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 7.951128e-02 1.100 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 7.951128e-02 1.100 0 0
Formation of the anterior neural plate R-HSA-9823739 7.951128e-02 1.100 0 0
Post NMDA receptor activation events R-HSA-438064 7.986070e-02 1.098 0 0
SARS-CoV-1-host interactions R-HSA-9692914 8.017064e-02 1.096 0 0
Breakdown of the nuclear lamina R-HSA-352238 8.031417e-02 1.095 0 0
Type I hemidesmosome assembly R-HSA-446107 9.490436e-02 1.023 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 9.490436e-02 1.023 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 9.490436e-02 1.023 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 8.772379e-02 1.057 0 0
Signaling by AMER1 mutants R-HSA-4839748 8.772379e-02 1.057 0 0
Signaling by GSK3beta mutants R-HSA-5339716 8.772379e-02 1.057 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 8.852435e-02 1.053 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 8.486059e-02 1.071 0 0
Signaling downstream of RAS mutants R-HSA-9649948 8.486059e-02 1.071 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 8.486059e-02 1.071 0 0
Viral mRNA Translation R-HSA-192823 8.941547e-02 1.049 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 8.602993e-02 1.065 0 0
Cellular response to heat stress R-HSA-3371556 8.197826e-02 1.086 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 8.645847e-02 1.063 0 0
DNA Double Strand Break Response R-HSA-5693606 8.395367e-02 1.076 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 8.772379e-02 1.057 0 0
Signaling by RAS mutants R-HSA-6802949 8.486059e-02 1.071 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 8.307162e-02 1.081 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 8.645847e-02 1.063 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 9.490436e-02 1.023 0 0
Neurexins and neuroligins R-HSA-6794361 9.173432e-02 1.037 0 0
Activation of ATR in response to replication stress R-HSA-176187 8.852435e-02 1.053 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 8.852435e-02 1.053 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 8.852435e-02 1.053 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 8.852435e-02 1.053 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 9.490436e-02 1.023 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 9.555144e-02 1.020 0 0
Prolonged ERK activation events R-HSA-169893 9.555144e-02 1.020 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 9.555144e-02 1.020 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.587116e-02 1.018 0 0
Protein-protein interactions at synapses R-HSA-6794362 9.684882e-02 1.014 0 0
Mitotic Prometaphase R-HSA-68877 9.710288e-02 1.013 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 9.741125e-02 1.011 0 0
IRS activation R-HSA-74713 9.741125e-02 1.011 0 0
G2 Phase R-HSA-68911 9.741125e-02 1.011 0 0
NrCAM interactions R-HSA-447038 9.741125e-02 1.011 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.441225e-01 0.841 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.441225e-01 0.841 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.441225e-01 0.841 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.441225e-01 0.841 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 1.441225e-01 0.841 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.441225e-01 0.841 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.293464e-01 0.888 0 0
Diseases of cellular response to stress R-HSA-9675132 1.293464e-01 0.888 0 0
Regulation of cortical dendrite branching R-HSA-8985801 1.293464e-01 0.888 0 0
Potassium transport channels R-HSA-1296067 1.293464e-01 0.888 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 2.674808e-01 0.573 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.674808e-01 0.573 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.674808e-01 0.573 0 0
Tandem pore domain halothane-inhibited K+ channel (THIK) R-HSA-1299287 2.674808e-01 0.573 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.674808e-01 0.573 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.674808e-01 0.573 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 2.674808e-01 0.573 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 2.674808e-01 0.573 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.674808e-01 0.573 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.833515e-01 0.737 0 0
Axonal growth stimulation R-HSA-209563 1.833515e-01 0.737 0 0
Invadopodia formation R-HSA-8941237 1.833515e-01 0.737 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.303697e-01 0.885 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 1.303697e-01 0.885 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 1.303697e-01 0.885 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 1.197191e-01 0.922 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.197191e-01 0.922 0 0
WNT mediated activation of DVL R-HSA-201688 1.197191e-01 0.922 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.197191e-01 0.922 0 0
ALK mutants bind TKIs R-HSA-9700645 1.197191e-01 0.922 0 0
CREB phosphorylation R-HSA-199920 1.666088e-01 0.778 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 1.666088e-01 0.778 0 0
NADE modulates death signalling R-HSA-205025 2.398790e-01 0.620 0 0
HCN channels R-HSA-1296061 2.398790e-01 0.620 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 2.398790e-01 0.620 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.398790e-01 0.620 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.398790e-01 0.620 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.398790e-01 0.620 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 2.398790e-01 0.620 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.398790e-01 0.620 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 2.398790e-01 0.620 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 3.730654e-01 0.428 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 3.730654e-01 0.428 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.730654e-01 0.428 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.730654e-01 0.428 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.730654e-01 0.428 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 3.730654e-01 0.428 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 3.730654e-01 0.428 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 3.730654e-01 0.428 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.730654e-01 0.428 0 0
XAV939 stabilizes AXIN R-HSA-5545619 3.730654e-01 0.428 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.730654e-01 0.428 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 3.730654e-01 0.428 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.730654e-01 0.428 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.730654e-01 0.428 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 3.730654e-01 0.428 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.730654e-01 0.428 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 3.730654e-01 0.428 0 0
Defective HK1 causes hexokinase deficiency (HK deficiency) R-HSA-5619056 3.730654e-01 0.428 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.730654e-01 0.428 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.730654e-01 0.428 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.730654e-01 0.428 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 3.730654e-01 0.428 0 0
Intestinal infectious diseases R-HSA-8942233 3.730654e-01 0.428 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 3.730654e-01 0.428 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.730654e-01 0.428 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.730654e-01 0.428 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.730654e-01 0.428 0 0
IKBKB deficiency causes SCID R-HSA-5602636 3.730654e-01 0.428 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.730654e-01 0.428 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.073864e-01 0.969 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.073864e-01 0.969 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.073864e-01 0.969 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.073864e-01 0.969 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.073864e-01 0.969 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.469970e-01 0.833 0 0
SOS-mediated signalling R-HSA-112412 2.053599e-01 0.687 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.053599e-01 0.687 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.131824e-01 0.946 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 1.764106e-01 0.753 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 1.764106e-01 0.753 0 0
Signaling by APC mutants R-HSA-4839744 1.764106e-01 0.753 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.764106e-01 0.753 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.764106e-01 0.753 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.764106e-01 0.753 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.970809e-01 0.527 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.970809e-01 0.527 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 9.942608e-02 1.002 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.524091e-01 0.817 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.323326e-01 0.878 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.323326e-01 0.878 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 2.458834e-01 0.609 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 2.458834e-01 0.609 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 2.076082e-01 0.683 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.076082e-01 0.683 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 2.076082e-01 0.683 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.076082e-01 0.683 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.774355e-01 0.751 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.774355e-01 0.751 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.529088e-01 0.816 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 1.529088e-01 0.816 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.325721e-01 0.878 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.154748e-01 0.938 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.154748e-01 0.938 0 0
TGFBR3 expression R-HSA-9839394 1.154748e-01 0.938 0 0
Striated Muscle Contraction R-HSA-390522 1.000129e-01 1.000 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.143002e-01 0.942 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 1.310769e-01 0.882 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 2.038790e-01 0.691 0 0
Differentiation of T cells R-HSA-9945266 2.038790e-01 0.691 0 0
Phase 4 - resting membrane potential R-HSA-5576886 2.038790e-01 0.691 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.038790e-01 0.691 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 2.402280e-01 0.619 0 0
p75NTR regulates axonogenesis R-HSA-193697 2.874947e-01 0.541 0 0
ARMS-mediated activation R-HSA-170984 2.874947e-01 0.541 0 0
Lipophagy R-HSA-9613354 2.874947e-01 0.541 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 3.535892e-01 0.452 0 0
Phosphorylation of Emi1 R-HSA-176417 3.535892e-01 0.452 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 3.535892e-01 0.452 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.535892e-01 0.452 0 0
Signaling by MAPK mutants R-HSA-9652817 3.535892e-01 0.452 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 4.634363e-01 0.334 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 4.634363e-01 0.334 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 4.634363e-01 0.334 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 4.634363e-01 0.334 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.634363e-01 0.334 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.634363e-01 0.334 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 2.315269e-01 0.635 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.315269e-01 0.635 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.739107e-01 0.562 0 0
Formation of axial mesoderm R-HSA-9796292 2.739107e-01 0.562 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.739107e-01 0.562 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.220057e-01 0.914 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.909832e-01 0.719 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.220099e-01 0.654 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.220099e-01 0.654 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 2.220099e-01 0.654 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 2.220099e-01 0.654 0 0
Formation of apoptosome R-HSA-111458 3.295787e-01 0.482 0 0
Regulation of the apoptosome activity R-HSA-9627069 3.295787e-01 0.482 0 0
PI3K/AKT activation R-HSA-198203 3.295787e-01 0.482 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 3.295787e-01 0.482 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.837910e-01 0.736 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.540895e-01 0.812 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.601598e-01 0.585 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.765912e-01 0.753 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.484367e-01 0.828 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.031348e-01 0.692 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 2.031348e-01 0.692 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.470458e-01 0.607 0 0
Autointegration results in viral DNA circles R-HSA-177539 4.084160e-01 0.389 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 4.084160e-01 0.389 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.941962e-01 0.712 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.084577e-01 0.965 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.856721e-01 0.731 0 0
PKA activation R-HSA-163615 2.895568e-01 0.538 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.497354e-01 0.825 0 0
Downstream signal transduction R-HSA-186763 2.232475e-01 0.651 0 0
Trafficking of AMPA receptors R-HSA-399719 2.232475e-01 0.651 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 2.728364e-01 0.564 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 2.728364e-01 0.564 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.715969e-01 0.430 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 3.715969e-01 0.430 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 3.715969e-01 0.430 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.625796e-01 0.789 0 0
Erythropoietin activates RAS R-HSA-9027284 3.430938e-01 0.465 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 3.430938e-01 0.465 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 3.430938e-01 0.465 0 0
Translation initiation complex formation R-HSA-72649 1.759656e-01 0.755 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 3.195004e-01 0.496 0 0
Interleukin receptor SHC signaling R-HSA-912526 2.992291e-01 0.524 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 2.992291e-01 0.524 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.654584e-01 0.576 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.654584e-01 0.576 0 0
MAP2K and MAPK activation R-HSA-5674135 2.378888e-01 0.624 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 2.378888e-01 0.624 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 2.378888e-01 0.624 0 0
HSF1-dependent transactivation R-HSA-3371571 2.146375e-01 0.668 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.855950e-01 0.731 0 0
Signaling by Erythropoietin R-HSA-9006335 3.055339e-01 0.515 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.055339e-01 0.515 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.055339e-01 0.515 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.260718e-01 0.487 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 3.260718e-01 0.487 0 0
Deadenylation of mRNA R-HSA-429947 3.260718e-01 0.487 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.497801e-01 0.456 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.497801e-01 0.456 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.497801e-01 0.456 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.497801e-01 0.456 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.779629e-01 0.423 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 4.130897e-01 0.384 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 4.130897e-01 0.384 0 0
ERKs are inactivated R-HSA-202670 4.130897e-01 0.384 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 4.608723e-01 0.336 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 4.608723e-01 0.336 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 4.608723e-01 0.336 0 0
TRIF-mediated programmed cell death R-HSA-2562578 4.608723e-01 0.336 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 4.608723e-01 0.336 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 4.608723e-01 0.336 0 0
The NLRP1 inflammasome R-HSA-844455 5.407850e-01 0.267 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 5.407850e-01 0.267 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 5.407850e-01 0.267 0 0
MET activates PTPN11 R-HSA-8865999 5.407850e-01 0.267 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 5.407850e-01 0.267 0 0
Classical Kir channels R-HSA-1296053 5.407850e-01 0.267 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 5.407850e-01 0.267 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 5.407850e-01 0.267 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 5.407850e-01 0.267 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.021038e-01 0.694 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.228858e-01 0.652 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.228858e-01 0.652 0 0
Meiotic synapsis R-HSA-1221632 2.469606e-01 0.607 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.260012e-01 0.646 0 0
DAP12 signaling R-HSA-2424491 3.300572e-01 0.481 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 3.300572e-01 0.481 0 0
Activation of the pre-replicative complex R-HSA-68962 3.300572e-01 0.481 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.300572e-01 0.481 0 0
Tight junction interactions R-HSA-420029 3.532155e-01 0.452 0 0
Centrosome maturation R-HSA-380287 2.286022e-01 0.641 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 4.126406e-01 0.384 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 4.126406e-01 0.384 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 3.144295e-01 0.502 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 3.144295e-01 0.502 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 2.984354e-01 0.525 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.805162e-01 0.420 0 0
p75NTR recruits signalling complexes R-HSA-209543 4.536743e-01 0.343 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.536743e-01 0.343 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 4.536743e-01 0.343 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 4.536743e-01 0.343 0 0
Scavenging by Class F Receptors R-HSA-3000484 4.536743e-01 0.343 0 0
G1/S-Specific Transcription R-HSA-69205 3.554079e-01 0.449 0 0
PTEN Regulation R-HSA-6807070 1.919634e-01 0.717 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 3.344220e-01 0.476 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 4.105608e-01 0.387 0 0
Inwardly rectifying K+ channels R-HSA-1296065 3.798188e-01 0.420 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 3.798188e-01 0.420 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 3.785328e-01 0.422 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 4.078365e-01 0.390 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 4.078365e-01 0.390 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 4.078365e-01 0.390 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 5.105023e-01 0.292 0 0
RSK activation R-HSA-444257 5.105023e-01 0.292 0 0
Regulation by c-FLIP R-HSA-3371378 5.105023e-01 0.292 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 5.105023e-01 0.292 0 0
Dimerization of procaspase-8 R-HSA-69416 5.105023e-01 0.292 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 5.105023e-01 0.292 0 0
MET receptor recycling R-HSA-8875656 5.105023e-01 0.292 0 0
Activation of RAS in B cells R-HSA-1169092 5.105023e-01 0.292 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.202654e-01 0.657 0 0
snRNP Assembly R-HSA-191859 3.525076e-01 0.453 0 0
Metabolism of non-coding RNA R-HSA-194441 3.525076e-01 0.453 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 3.496822e-01 0.456 0 0
Regulation of endogenous retroelements R-HSA-9842860 3.123735e-01 0.505 0 0
HIV elongation arrest and recovery R-HSA-167287 4.350469e-01 0.361 0 0
Pausing and recovery of HIV elongation R-HSA-167290 4.350469e-01 0.361 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.930401e-01 0.307 0 0
HDACs deacetylate histones R-HSA-3214815 3.924389e-01 0.406 0 0
PKA activation in glucagon signalling R-HSA-164378 4.804736e-01 0.318 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.752104e-01 0.426 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 4.620270e-01 0.335 0 0
Late endosomal microautophagy R-HSA-9615710 4.620270e-01 0.335 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 4.480766e-01 0.349 0 0
Attenuation phase R-HSA-3371568 4.480766e-01 0.349 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 4.480766e-01 0.349 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 4.097508e-01 0.387 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.637046e-01 0.334 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 4.710527e-01 0.327 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 4.886665e-01 0.311 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 4.886665e-01 0.311 0 0
Regulation of signaling by CBL R-HSA-912631 5.132321e-01 0.290 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 5.132321e-01 0.290 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 5.309432e-01 0.275 0 0
CASP8 activity is inhibited R-HSA-5218900 5.570311e-01 0.254 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.773872e-01 0.321 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.773872e-01 0.321 0 0
HSF1 activation R-HSA-3371511 5.035769e-01 0.298 0 0
PRC2 methylates histones and DNA R-HSA-212300 5.035769e-01 0.298 0 0
EGFR downregulation R-HSA-182971 5.148652e-01 0.288 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 5.148652e-01 0.288 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 5.148652e-01 0.288 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 4.895747e-01 0.310 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 5.283029e-01 0.277 0 0
G protein gated Potassium channels R-HSA-1296059 5.283029e-01 0.277 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 5.283029e-01 0.277 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 5.283029e-01 0.277 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 5.162716e-01 0.287 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 5.450047e-01 0.264 0 0
Co-inhibition by CTLA4 R-HSA-389513 5.450047e-01 0.264 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 4.923548e-01 0.308 0 0
Degradation of DVL R-HSA-4641258 5.274919e-01 0.278 0 0
Spry regulation of FGF signaling R-HSA-1295596 5.671995e-01 0.246 0 0
SHC1 events in EGFR signaling R-HSA-180336 5.671995e-01 0.246 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 5.671995e-01 0.246 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.671995e-01 0.246 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 5.561518e-01 0.255 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 5.444286e-01 0.264 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 5.655927e-01 0.247 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 5.756670e-01 0.240 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 5.738940e-01 0.241 0 0
Signaling by EGFR R-HSA-177929 4.119312e-01 0.385 0 0
FOXO-mediated transcription R-HSA-9614085 9.974133e-02 1.001 0 0
Regulation of mitotic cell cycle R-HSA-453276 4.577277e-01 0.339 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 4.577277e-01 0.339 0 0
Circadian clock R-HSA-9909396 2.288949e-01 0.640 0 0
G1/S Transition R-HSA-69206 3.449953e-01 0.462 0 0
Insulin receptor signalling cascade R-HSA-74751 4.452292e-01 0.351 0 0
Signaling by FGFR4 R-HSA-5654743 3.986149e-01 0.399 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 4.774294e-01 0.321 0 0
Co-stimulation by CD28 R-HSA-389356 1.698775e-01 0.770 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.617098e-01 0.791 0 0
IGF1R signaling cascade R-HSA-2428924 2.376355e-01 0.624 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 3.805162e-01 0.420 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 2.106708e-01 0.676 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.302974e-01 0.885 0 0
Formation of definitive endoderm R-HSA-9823730 9.942608e-02 1.002 0 0
p75NTR signals via NF-kB R-HSA-193639 3.430938e-01 0.465 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.704553e-01 0.768 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.510425e-01 0.600 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.086823e-01 0.294 0 0
Signaling by FGFR3 R-HSA-5654741 4.420872e-01 0.354 0 0
Hedgehog 'off' state R-HSA-5610787 3.699240e-01 0.432 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 4.255242e-01 0.371 0 0
Ribosome-associated quality control R-HSA-9948299 2.391839e-01 0.621 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.604468e-01 0.584 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 4.365699e-01 0.360 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 5.450047e-01 0.264 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 4.255242e-01 0.371 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 4.255242e-01 0.371 0 0
Apoptotic factor-mediated response R-HSA-111471 1.529088e-01 0.816 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 4.130897e-01 0.384 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 4.126406e-01 0.384 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 5.273755e-01 0.278 0 0
IRS-mediated signalling R-HSA-112399 5.567142e-01 0.254 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 5.813696e-01 0.236 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.693255e-01 0.771 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.344220e-01 0.476 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 1.197191e-01 0.922 0 0
Synaptic adhesion-like molecules R-HSA-8849932 1.529088e-01 0.816 0 0
Platelet calcium homeostasis R-HSA-418360 1.837910e-01 0.736 0 0
Meiosis R-HSA-1500620 1.446935e-01 0.840 0 0
Separation of Sister Chromatids R-HSA-2467813 1.233283e-01 0.909 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 5.891678e-01 0.230 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.402413e-01 0.619 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 2.402413e-01 0.619 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 2.353376e-01 0.628 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 3.835603e-01 0.416 0 0
TCR signaling R-HSA-202403 3.512819e-01 0.454 0 0
NGF-stimulated transcription R-HSA-9031628 1.698775e-01 0.770 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.146229e-01 0.941 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.146229e-01 0.941 0 0
TNF signaling R-HSA-75893 4.119312e-01 0.385 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.727617e-01 0.763 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.484367e-01 0.828 0 0
NRIF signals cell death from the nucleus R-HSA-205043 3.083086e-01 0.511 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 4.126406e-01 0.384 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 3.079748e-01 0.511 0 0
Frs2-mediated activation R-HSA-170968 1.289993e-01 0.889 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 2.995716e-01 0.523 0 0
Resolution of D-Loop Structures R-HSA-5693537 4.298206e-01 0.367 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.321922e-01 0.879 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 2.527602e-01 0.597 0 0
Homology Directed Repair R-HSA-5693538 3.216474e-01 0.493 0 0
Formation of the posterior neural plate R-HSA-9832991 1.764106e-01 0.753 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 2.874947e-01 0.541 0 0
Pyroptosis R-HSA-5620971 1.652899e-01 0.782 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 3.295787e-01 0.482 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.269894e-01 0.896 0 0
DARPP-32 events R-HSA-180024 3.055339e-01 0.515 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 4.048410e-01 0.393 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 4.930401e-01 0.307 0 0
PI3K Cascade R-HSA-109704 5.480303e-01 0.261 0 0
Regulated Necrosis R-HSA-5218859 3.000887e-01 0.523 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.472518e-01 0.832 0 0
RMTs methylate histone arginines R-HSA-3214858 1.183587e-01 0.927 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 4.126406e-01 0.384 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.133290e-01 0.504 0 0
Interleukin-1 signaling R-HSA-9020702 4.774294e-01 0.321 0 0
Signaling by WNT in cancer R-HSA-4791275 1.437316e-01 0.842 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 3.532155e-01 0.452 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.230945e-01 0.491 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 2.398790e-01 0.620 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.289993e-01 0.889 0 0
Formation of lateral plate mesoderm R-HSA-9758920 3.535892e-01 0.452 0 0
Regulation of CDH11 function R-HSA-9762292 3.295787e-01 0.482 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 4.608723e-01 0.336 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 3.097471e-01 0.509 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 4.468821e-01 0.350 0 0
Potassium Channels R-HSA-1296071 3.133290e-01 0.504 0 0
Processing of SMDT1 R-HSA-8949664 4.930401e-01 0.307 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.621518e-01 0.441 0 0
Stabilization of p53 R-HSA-69541 4.249475e-01 0.372 0 0
Meiotic recombination R-HSA-912446 4.365699e-01 0.360 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 5.570311e-01 0.254 0 0
Switching of origins to a post-replicative state R-HSA-69052 4.931115e-01 0.307 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.626783e-01 0.789 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.540895e-01 0.812 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.031348e-01 0.692 0 0
Signalling to ERKs R-HSA-187687 2.125135e-01 0.673 0 0
G-protein mediated events R-HSA-112040 3.864615e-01 0.413 0 0
Opioid Signalling R-HSA-111885 5.219561e-01 0.282 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 3.195004e-01 0.496 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 3.798188e-01 0.420 0 0
Effects of PIP2 hydrolysis R-HSA-114508 4.298206e-01 0.367 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 4.546618e-01 0.342 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 5.198445e-01 0.284 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 4.628163e-01 0.335 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.469970e-01 0.833 0 0
Mitotic Prophase R-HSA-68875 1.100463e-01 0.958 0 0
Cyclin D associated events in G1 R-HSA-69231 4.203696e-01 0.376 0 0
G1 Phase R-HSA-69236 4.203696e-01 0.376 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.599530e-01 0.444 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 4.078365e-01 0.390 0 0
Regulation of necroptotic cell death R-HSA-5675482 5.655927e-01 0.247 0 0
GPVI-mediated activation cascade R-HSA-114604 2.314836e-01 0.635 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.398790e-01 0.620 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.073864e-01 0.969 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 2.970809e-01 0.527 0 0
Adrenoceptors R-HSA-390696 2.458834e-01 0.609 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 2.458834e-01 0.609 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 2.874947e-01 0.541 0 0
DAG and IP3 signaling R-HSA-1489509 1.302974e-01 0.885 0 0
NF-kB is activated and signals survival R-HSA-209560 4.130897e-01 0.384 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 4.536743e-01 0.343 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 4.930401e-01 0.307 0 0
Orc1 removal from chromatin R-HSA-68949 4.570354e-01 0.340 0 0
cGMP effects R-HSA-418457 5.309432e-01 0.275 0 0
Activation of BH3-only proteins R-HSA-114452 3.300572e-01 0.481 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 4.407022e-01 0.356 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.172417e-01 0.663 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 3.342946e-01 0.476 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.310769e-01 0.882 0 0
PLC beta mediated events R-HSA-112043 2.827147e-01 0.549 0 0
Receptor Mediated Mitophagy R-HSA-8934903 3.295787e-01 0.482 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.097471e-01 0.509 0 0
Long-term potentiation R-HSA-9620244 3.532155e-01 0.452 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.912543e-01 0.718 0 0
Repression of WNT target genes R-HSA-4641265 4.536743e-01 0.343 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 4.298206e-01 0.367 0 0
S Phase R-HSA-69242 1.765032e-01 0.753 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 5.030934e-01 0.298 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 3.378342e-01 0.471 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 2.038790e-01 0.691 0 0
Triglyceride catabolism R-HSA-163560 2.314836e-01 0.635 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 3.342946e-01 0.476 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 3.729346e-01 0.428 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.912543e-01 0.718 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.912543e-01 0.718 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 3.345329e-01 0.476 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 3.729346e-01 0.428 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.484367e-01 0.828 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.506208e-01 0.822 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.506208e-01 0.822 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.441244e-01 0.612 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.364463e-01 0.626 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 2.970809e-01 0.527 0 0
TGFBR3 PTM regulation R-HSA-9839383 2.458834e-01 0.609 0 0
Calcineurin activates NFAT R-HSA-2025928 2.874947e-01 0.541 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.535892e-01 0.452 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 2.739107e-01 0.562 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 3.083086e-01 0.511 0 0
Abacavir transmembrane transport R-HSA-2161517 4.084160e-01 0.389 0 0
Ca-dependent events R-HSA-111996 1.626783e-01 0.789 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.321922e-01 0.879 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 4.608723e-01 0.336 0 0
Ca2+ activated K+ channels R-HSA-1296052 4.608723e-01 0.336 0 0
Cardiac conduction R-HSA-5576891 1.208557e-01 0.918 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.682310e-01 0.571 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 5.105023e-01 0.292 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 4.048410e-01 0.393 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.245177e-01 0.489 0 0
Aggrephagy R-HSA-9646399 4.480766e-01 0.349 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 3.338385e-01 0.476 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.676243e-01 0.435 0 0
GP1b-IX-V activation signalling R-HSA-430116 5.570311e-01 0.254 0 0
Autophagy R-HSA-9612973 1.939116e-01 0.712 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.079748e-01 0.511 0 0
Hedgehog 'on' state R-HSA-5632684 4.577277e-01 0.339 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 4.350410e-01 0.361 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.009537e-01 0.996 0 0
Kinesins R-HSA-983189 1.811515e-01 0.742 0 0
Recycling pathway of L1 R-HSA-437239 4.851620e-01 0.314 0 0
Neuronal System R-HSA-112316 5.205872e-01 0.284 0 0
Signaling by SCF-KIT R-HSA-1433557 3.986149e-01 0.399 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.491638e-01 0.457 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 3.922392e-01 0.406 0 0
Gastrulation R-HSA-9758941 5.256348e-01 0.279 0 0
Interleukin-2 signaling R-HSA-9020558 3.715969e-01 0.430 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.512819e-01 0.454 0 0
MyD88-independent TLR4 cascade R-HSA-166166 3.512819e-01 0.454 0 0
Signaling by FGFR in disease R-HSA-1226099 5.106231e-01 0.292 0 0
mTORC1-mediated signalling R-HSA-166208 1.509567e-01 0.821 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 3.083086e-01 0.511 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 4.536743e-01 0.343 0 0
Ub-specific processing proteases R-HSA-5689880 3.067262e-01 0.513 0 0
Deubiquitination R-HSA-5688426 2.305116e-01 0.637 0 0
Developmental Biology R-HSA-1266738 3.057663e-01 0.515 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 3.003287e-01 0.522 0 0
Cell junction organization R-HSA-446728 1.807565e-01 0.743 0 0
Adherens junctions interactions R-HSA-418990 3.946938e-01 0.404 0 0
Cell-cell junction organization R-HSA-421270 3.508989e-01 0.455 0 0
Membrane Trafficking R-HSA-199991 4.388273e-01 0.358 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 5.030934e-01 0.298 0 0
Interleukin-2 family signaling R-HSA-451927 3.125718e-01 0.505 0 0
Muscle contraction R-HSA-397014 1.098019e-01 0.959 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 3.430938e-01 0.465 0 0
G-protein beta:gamma signalling R-HSA-397795 2.654584e-01 0.576 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 4.017401e-01 0.396 0 0
Interleukin-1 family signaling R-HSA-446652 2.690756e-01 0.570 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.855235e-01 0.544 0 0
Signaling by TGFB family members R-HSA-9006936 2.293833e-01 0.639 0 0
Diseases of programmed cell death R-HSA-9645723 4.417160e-01 0.355 0 0
Signaling by NOTCH1 R-HSA-1980143 5.451331e-01 0.263 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.395988e-01 0.469 0 0
Cellular response to chemical stress R-HSA-9711123 5.696305e-01 0.244 0 0
Macroautophagy R-HSA-1632852 2.703724e-01 0.568 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 5.283029e-01 0.277 0 0
Cell-Cell communication R-HSA-1500931 2.300010e-01 0.638 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 2.076082e-01 0.683 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.325721e-01 0.878 0 0
ERK/MAPK targets R-HSA-198753 3.801960e-01 0.420 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.324502e-01 0.478 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.337966e-01 0.477 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 5.288681e-01 0.277 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.654584e-01 0.576 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 4.060382e-01 0.391 0 0
Protein methylation R-HSA-8876725 3.430938e-01 0.465 0 0
The NLRP3 inflammasome R-HSA-844456 3.195004e-01 0.496 0 0
mRNA Editing R-HSA-75072 5.570311e-01 0.254 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.315269e-01 0.635 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.909832e-01 0.719 0 0
Neurodegenerative Diseases R-HSA-8863678 1.909832e-01 0.719 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.436619e-01 0.843 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.621417e-01 0.581 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 4.407022e-01 0.356 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.126656e-01 0.672 0 0
Signaling by TGFBR3 R-HSA-9839373 1.428752e-01 0.845 0 0
Selective autophagy R-HSA-9663891 5.444286e-01 0.264 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.771370e-01 0.752 0 0
Signaling by PTK6 R-HSA-8848021 2.228858e-01 0.652 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.228858e-01 0.652 0 0
MAPK family signaling cascades R-HSA-5683057 1.317699e-01 0.880 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.674808e-01 0.573 0 0
Regulation of KIT signaling R-HSA-1433559 1.524091e-01 0.817 0 0
Signaling by AXIN mutants R-HSA-4839735 2.076082e-01 0.683 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.529088e-01 0.816 0 0
Unwinding of DNA R-HSA-176974 2.874947e-01 0.541 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 3.535892e-01 0.452 0 0
mRNA Editing: A to I Conversion R-HSA-75064 4.634363e-01 0.334 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 4.634363e-01 0.334 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 4.634363e-01 0.334 0 0
C6 deamination of adenosine R-HSA-75102 4.634363e-01 0.334 0 0
Tandem pore domain potassium channels R-HSA-1296346 3.295787e-01 0.482 0 0
Bicarbonate transporters R-HSA-425381 3.715969e-01 0.430 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.055339e-01 0.515 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 5.407850e-01 0.267 0 0
MET interacts with TNS proteins R-HSA-8875513 5.407850e-01 0.267 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.344579e-01 0.630 0 0
Disorders of Developmental Biology R-HSA-9675151 4.126406e-01 0.384 0 0
MAP kinase activation R-HSA-450294 2.827147e-01 0.549 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 4.105608e-01 0.387 0 0
Co-stimulation by ICOS R-HSA-9927354 5.105023e-01 0.292 0 0
Inflammasomes R-HSA-622312 4.350469e-01 0.361 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 4.804736e-01 0.318 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 4.546618e-01 0.342 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 4.480766e-01 0.349 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 4.524266e-01 0.344 0 0
FLT3 Signaling R-HSA-9607240 2.198995e-01 0.658 0 0
FLT3 signaling in disease R-HSA-9682385 2.314836e-01 0.635 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.938061e-01 0.306 0 0
Signaling by FGFR4 in disease R-HSA-5655291 5.309432e-01 0.275 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 5.620752e-01 0.250 0 0
L1CAM interactions R-HSA-373760 4.615032e-01 0.336 0 0
Interleukin-17 signaling R-HSA-448424 4.399211e-01 0.357 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.452292e-01 0.351 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.909832e-01 0.719 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 4.797044e-01 0.319 0 0
Amine ligand-binding receptors R-HSA-375280 5.601052e-01 0.252 0 0
Stimuli-sensing channels R-HSA-2672351 2.488304e-01 0.604 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.197191e-01 0.922 0 0
PECAM1 interactions R-HSA-210990 3.715969e-01 0.430 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.855169e-01 0.732 0 0
Signaling by ERBB4 R-HSA-1236394 5.106231e-01 0.292 0 0
Formation of the nephric duct R-HSA-9830364 3.532155e-01 0.452 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.469970e-01 0.833 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 5.655927e-01 0.247 0 0
PI Metabolism R-HSA-1483255 1.727617e-01 0.763 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.246578e-01 0.904 0 0
Interleukin-1 processing R-HSA-448706 1.197191e-01 0.922 0 0
Cell-extracellular matrix interactions R-HSA-446353 3.430938e-01 0.465 0 0
Heme signaling R-HSA-9707616 2.085385e-01 0.681 0 0
CHL1 interactions R-HSA-447041 4.608723e-01 0.336 0 0
Disorders of Nervous System Development R-HSA-9697154 4.536743e-01 0.343 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 4.536743e-01 0.343 0 0
Pervasive developmental disorders R-HSA-9005895 4.536743e-01 0.343 0 0
Uptake and function of anthrax toxins R-HSA-5210891 4.468821e-01 0.350 0 0
Cellular response to starvation R-HSA-9711097 3.330484e-01 0.477 0 0
Glycolysis R-HSA-70171 3.699240e-01 0.432 0 0
Nephrin family interactions R-HSA-373753 5.450047e-01 0.264 0 0
Signaling by ALK in cancer R-HSA-9700206 1.246578e-01 0.904 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.080178e-01 0.967 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 2.053599e-01 0.687 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 4.930401e-01 0.307 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.078365e-01 0.390 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.895568e-01 0.538 0 0
Signal transduction by L1 R-HSA-445144 5.450047e-01 0.264 0 0
Interleukin-15 signaling R-HSA-8983432 4.536743e-01 0.343 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 1.833515e-01 0.737 0 0
DSCAM interactions R-HSA-376172 4.634363e-01 0.334 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.470458e-01 0.607 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 4.084160e-01 0.389 0 0
Syndecan interactions R-HSA-3000170 2.992291e-01 0.524 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 2.258033e-01 0.646 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 5.407850e-01 0.267 0 0
Signaling by ALK R-HSA-201556 2.916568e-01 0.535 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 4.468821e-01 0.350 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 3.730086e-01 0.428 0 0
Maturation of nucleoprotein R-HSA-9683610 4.930401e-01 0.307 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 5.738940e-01 0.241 0 0
STING mediated induction of host immune responses R-HSA-1834941 5.132321e-01 0.290 0 0
Glucose metabolism R-HSA-70326 5.642123e-01 0.249 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 3.801960e-01 0.420 0 0
Cytokine Signaling in Immune system R-HSA-1280215 4.609524e-01 0.336 0 0
Interleukin-37 signaling R-HSA-9008059 1.143002e-01 0.942 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 4.084160e-01 0.389 0 0
Histamine receptors R-HSA-390650 5.407850e-01 0.267 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 5.570311e-01 0.254 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 5.671995e-01 0.246 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 1.833515e-01 0.737 0 0
Sodium/Proton exchangers R-HSA-425986 2.458834e-01 0.609 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.634363e-01 0.334 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 4.634363e-01 0.334 0 0
Interleukin-18 signaling R-HSA-9012546 5.105023e-01 0.292 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 5.570311e-01 0.254 0 0
Interleukin-7 signaling R-HSA-1266695 2.124459e-01 0.673 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 5.561518e-01 0.255 0 0
HDL assembly R-HSA-8963896 3.083086e-01 0.511 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.729677e-01 0.762 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 4.608723e-01 0.336 0 0
FasL/ CD95L signaling R-HSA-75157 5.407850e-01 0.267 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 5.570311e-01 0.254 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 5.570311e-01 0.254 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 5.671995e-01 0.246 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 5.756670e-01 0.240 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.804736e-01 0.318 0 0
Influenza Infection R-HSA-168255 3.698171e-01 0.432 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 4.509096e-01 0.346 0 0
Interleukin-12 signaling R-HSA-9020591 3.320246e-01 0.479 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 5.570311e-01 0.254 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 5.738940e-01 0.241 0 0
Interleukin-12 family signaling R-HSA-447115 5.284591e-01 0.277 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 1.509567e-01 0.821 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 5.899746e-01 0.229 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 5.899746e-01 0.229 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.945540e-01 0.226 0 0
Triglyceride metabolism R-HSA-8979227 5.945540e-01 0.226 0 0
HIV Transcription Elongation R-HSA-167169 5.962661e-01 0.225 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 5.962661e-01 0.225 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 5.962661e-01 0.225 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 5.962661e-01 0.225 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.968786e-01 0.224 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 6.003214e-01 0.222 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 6.003214e-01 0.222 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 6.003214e-01 0.222 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 6.003214e-01 0.222 0 0
Arachidonate production from DAG R-HSA-426048 6.003214e-01 0.222 0 0
Pexophagy R-HSA-9664873 6.003214e-01 0.222 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 6.003214e-01 0.222 0 0
2-LTR circle formation R-HSA-164843 6.003214e-01 0.222 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 6.003214e-01 0.222 0 0
Signaling by Leptin R-HSA-2586552 6.003214e-01 0.222 0 0
Phosphorylation of the APC/C R-HSA-176412 6.016777e-01 0.221 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 6.016777e-01 0.221 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.016777e-01 0.221 0 0
Killing mechanisms R-HSA-9664420 6.016777e-01 0.221 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.016777e-01 0.221 0 0
Diseases of DNA repair R-HSA-9675135 6.021391e-01 0.220 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 6.051212e-01 0.218 0 0
Mitochondrial calcium ion transport R-HSA-8949215 6.051212e-01 0.218 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 6.051212e-01 0.218 0 0
TNFR1-mediated ceramide production R-HSA-5626978 6.069872e-01 0.217 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 6.069872e-01 0.217 0 0
ATP sensitive Potassium channels R-HSA-1296025 6.069872e-01 0.217 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 6.069872e-01 0.217 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 6.069872e-01 0.217 0 0
Signaling by MAP2K mutants R-HSA-9652169 6.069872e-01 0.217 0 0
Regulation of gap junction activity R-HSA-191650 6.069872e-01 0.217 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 6.069872e-01 0.217 0 0
Alanine metabolism R-HSA-8964540 6.069872e-01 0.217 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 6.069872e-01 0.217 0 0
MDK and PTN in ALK signaling R-HSA-9851151 6.069872e-01 0.217 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 6.069872e-01 0.217 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 6.069872e-01 0.217 0 0
Regulation of PTEN stability and activity R-HSA-8948751 6.076650e-01 0.216 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 6.092585e-01 0.215 0 0
Telomere Extension By Telomerase R-HSA-171319 6.092585e-01 0.215 0 0
Signaling by FGFR2 R-HSA-5654738 6.113499e-01 0.214 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 6.128965e-01 0.213 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 6.128965e-01 0.213 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 6.128965e-01 0.213 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 6.128965e-01 0.213 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 6.128965e-01 0.213 0 0
NOD1/2 Signaling Pathway R-HSA-168638 6.136213e-01 0.212 0 0
Nuclear import of Rev protein R-HSA-180746 6.136213e-01 0.212 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 6.136213e-01 0.212 0 0
XBP1(S) activates chaperone genes R-HSA-381038 6.163792e-01 0.210 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 6.178736e-01 0.209 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 6.180213e-01 0.209 0 0
Signaling by Hedgehog R-HSA-5358351 6.185000e-01 0.209 0 0
Ion channel transport R-HSA-983712 6.197591e-01 0.208 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 6.223754e-01 0.206 0 0
SARS-CoV-2-host interactions R-HSA-9705683 6.241255e-01 0.205 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 6.271849e-01 0.203 0 0
DNA Repair R-HSA-73894 6.287178e-01 0.202 0 0
Activation of HOX genes during differentiation R-HSA-5619507 6.302108e-01 0.201 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 6.302108e-01 0.201 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 6.313626e-01 0.200 0 0
FGFR2 alternative splicing R-HSA-6803529 6.332939e-01 0.198 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 6.332939e-01 0.198 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 6.342924e-01 0.198 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 6.342924e-01 0.198 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 6.342924e-01 0.198 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 6.342924e-01 0.198 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 6.342924e-01 0.198 0 0
Response to metal ions R-HSA-5660526 6.342924e-01 0.198 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 6.343831e-01 0.198 0 0
DNA methylation R-HSA-5334118 6.343831e-01 0.198 0 0
Regulation of gene expression in beta cells R-HSA-210745 6.343831e-01 0.198 0 0
Transcription of the HIV genome R-HSA-167172 6.348812e-01 0.197 0 0
Assembly of the pre-replicative complex R-HSA-68867 6.357863e-01 0.197 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 6.364850e-01 0.196 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 6.364850e-01 0.196 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 6.364850e-01 0.196 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 6.364850e-01 0.196 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 6.403399e-01 0.194 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 6.403399e-01 0.194 0 0
Ionotropic activity of kainate receptors R-HSA-451306 6.403399e-01 0.194 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 6.403399e-01 0.194 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 6.482903e-01 0.188 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 6.498961e-01 0.187 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 6.585272e-01 0.181 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 6.601338e-01 0.180 0 0
rRNA processing R-HSA-72312 6.613066e-01 0.180 0 0
Signaling by FGFR1 R-HSA-5654736 6.630882e-01 0.178 0 0
Activation of AMPA receptors R-HSA-399710 6.636487e-01 0.178 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 6.636487e-01 0.178 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 6.636487e-01 0.178 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 6.636487e-01 0.178 0 0
Defective F9 activation R-HSA-9673221 6.636487e-01 0.178 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 6.636487e-01 0.178 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 6.636487e-01 0.178 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 6.636487e-01 0.178 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.636487e-01 0.178 0 0
Activation of AKT2 R-HSA-165158 6.636487e-01 0.178 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 6.636487e-01 0.178 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 6.636487e-01 0.178 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.636487e-01 0.178 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 6.636487e-01 0.178 0 0
PTK6 Down-Regulation R-HSA-8849472 6.636487e-01 0.178 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 6.636487e-01 0.178 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 6.636487e-01 0.178 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 6.636487e-01 0.178 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 6.641229e-01 0.178 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.649973e-01 0.177 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.649973e-01 0.177 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 6.649973e-01 0.177 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.649973e-01 0.177 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.649973e-01 0.177 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 6.652968e-01 0.177 0 0
Integration of energy metabolism R-HSA-163685 6.733728e-01 0.172 0 0
Downstream TCR signaling R-HSA-202424 6.752401e-01 0.171 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 6.771301e-01 0.169 0 0
Integration of provirus R-HSA-162592 6.771301e-01 0.169 0 0
Sodium/Calcium exchangers R-HSA-425561 6.771301e-01 0.169 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 6.771301e-01 0.169 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 6.792247e-01 0.168 0 0
Regulation of RAS by GAPs R-HSA-5658442 6.795817e-01 0.168 0 0
Platelet activation, signaling and aggregation R-HSA-76002 6.797110e-01 0.168 0 0
Ion transport by P-type ATPases R-HSA-936837 6.818186e-01 0.166 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 6.834051e-01 0.165 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 6.856093e-01 0.164 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 6.856093e-01 0.164 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 6.856093e-01 0.164 0 0
Plasma lipoprotein assembly R-HSA-8963898 6.856093e-01 0.164 0 0
Clathrin-mediated endocytosis R-HSA-8856828 6.874118e-01 0.163 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.891280e-01 0.162 0 0
GAB1 signalosome R-HSA-180292 6.937788e-01 0.159 0 0
Tie2 Signaling R-HSA-210993 6.937788e-01 0.159 0 0
Selenoamino acid metabolism R-HSA-2408522 6.954000e-01 0.158 0 0
DNA Replication Pre-Initiation R-HSA-69002 6.955392e-01 0.158 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 6.961379e-01 0.157 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 6.981848e-01 0.156 0 0
DAP12 interactions R-HSA-2172127 6.981848e-01 0.156 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 6.986946e-01 0.156 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 6.986946e-01 0.156 0 0
Chromosome Maintenance R-HSA-73886 6.999472e-01 0.155 0 0
MET promotes cell motility R-HSA-8875878 7.000378e-01 0.155 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 7.000378e-01 0.155 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 7.000378e-01 0.155 0 0
IRE1alpha activates chaperones R-HSA-381070 7.026633e-01 0.153 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 7.035345e-01 0.153 0 0
DNA strand elongation R-HSA-69190 7.035345e-01 0.153 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.069099e-01 0.151 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 7.078063e-01 0.150 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.097063e-01 0.149 0 0
IRAK1 recruits IKK complex R-HSA-937039 7.107911e-01 0.148 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 7.107911e-01 0.148 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.107911e-01 0.148 0 0
MET activates RAS signaling R-HSA-8851805 7.107911e-01 0.148 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 7.107911e-01 0.148 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 7.107911e-01 0.148 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 7.107911e-01 0.148 0 0
OAS antiviral response R-HSA-8983711 7.107911e-01 0.148 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 7.121440e-01 0.147 0 0
PKB-mediated events R-HSA-109703 7.121440e-01 0.147 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 7.121440e-01 0.147 0 0
PDE3B signalling R-HSA-165160 7.121440e-01 0.147 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 7.121440e-01 0.147 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 7.121440e-01 0.147 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 7.121440e-01 0.147 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 7.121440e-01 0.147 0 0
Signaling by RNF43 mutants R-HSA-5340588 7.121440e-01 0.147 0 0
Signaling by MST1 R-HSA-8852405 7.121440e-01 0.147 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 7.121440e-01 0.147 0 0
Pentose phosphate pathway disease R-HSA-6791465 7.121440e-01 0.147 0 0
NGF-independant TRKA activation R-HSA-187024 7.121440e-01 0.147 0 0
Ceramide signalling R-HSA-193681 7.121440e-01 0.147 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 7.121440e-01 0.147 0 0
Formation of the Editosome R-HSA-75094 7.121440e-01 0.147 0 0
Sensory perception of salty taste R-HSA-9730628 7.121440e-01 0.147 0 0
Synthesis of PS R-HSA-1483101 7.121440e-01 0.147 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 7.121440e-01 0.147 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 7.121440e-01 0.147 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 7.121440e-01 0.147 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 7.121440e-01 0.147 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 7.121440e-01 0.147 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 7.121440e-01 0.147 0 0
TRAIL signaling R-HSA-75158 7.121440e-01 0.147 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 7.121440e-01 0.147 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 7.121440e-01 0.147 0 0
Ca2+ pathway R-HSA-4086398 7.135218e-01 0.147 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.140440e-01 0.146 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 7.145837e-01 0.146 0 0
Nucleosome assembly R-HSA-774815 7.163962e-01 0.145 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 7.163962e-01 0.145 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 7.163962e-01 0.145 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 7.206506e-01 0.142 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 7.206506e-01 0.142 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.206506e-01 0.142 0 0
Specification of the neural plate border R-HSA-9834899 7.206506e-01 0.142 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 7.206506e-01 0.142 0 0
Maturation of nucleoprotein R-HSA-9694631 7.206506e-01 0.142 0 0
Other interleukin signaling R-HSA-449836 7.206506e-01 0.142 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 7.244409e-01 0.140 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 7.244409e-01 0.140 0 0
Signaling by NOTCH4 R-HSA-9013694 7.278783e-01 0.138 0 0
GABA receptor activation R-HSA-977443 7.293578e-01 0.137 0 0
Myogenesis R-HSA-525793 7.324257e-01 0.135 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 7.324257e-01 0.135 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.324257e-01 0.135 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.324257e-01 0.135 0 0
Mitochondrial biogenesis R-HSA-1592230 7.324621e-01 0.135 0 0
Host Interactions of HIV factors R-HSA-162909 7.336913e-01 0.134 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 7.338502e-01 0.134 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 7.338502e-01 0.134 0 0
Generation of second messenger molecules R-HSA-202433 7.380136e-01 0.132 0 0
Diseases of Immune System R-HSA-5260271 7.380136e-01 0.132 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.380136e-01 0.132 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 7.380136e-01 0.132 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 7.380136e-01 0.132 0 0
Glycogen metabolism R-HSA-8982491 7.380136e-01 0.132 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 7.380136e-01 0.132 0 0
SARS-CoV-2 Infection R-HSA-9694516 7.406652e-01 0.130 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 7.414602e-01 0.130 0 0
CD28 dependent Vav1 pathway R-HSA-389359 7.414602e-01 0.130 0 0
rRNA modification in the mitochondrion R-HSA-6793080 7.414602e-01 0.130 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 7.414602e-01 0.130 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 7.414602e-01 0.130 0 0
ISG15 antiviral mechanism R-HSA-1169408 7.417580e-01 0.130 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 7.442661e-01 0.128 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 7.442661e-01 0.128 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 7.444777e-01 0.128 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.456485e-01 0.127 0 0
Signaling by NODAL R-HSA-1181150 7.456485e-01 0.127 0 0
Creatine metabolism R-HSA-71288 7.456485e-01 0.127 0 0
Protein hydroxylation R-HSA-9629569 7.456485e-01 0.127 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 7.505431e-01 0.125 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 7.536495e-01 0.123 0 0
Erythropoietin activates STAT5 R-HSA-9027283 7.536495e-01 0.123 0 0
STAT5 Activation R-HSA-9645135 7.536495e-01 0.123 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 7.536495e-01 0.123 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 7.536495e-01 0.123 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 7.536495e-01 0.123 0 0
G2/M DNA replication checkpoint R-HSA-69478 7.536495e-01 0.123 0 0
Neurofascin interactions R-HSA-447043 7.536495e-01 0.123 0 0
Lactose synthesis R-HSA-5653890 7.536495e-01 0.123 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 7.536495e-01 0.123 0 0
Nef and signal transduction R-HSA-164944 7.536495e-01 0.123 0 0
Lipid particle organization R-HSA-8964572 7.536495e-01 0.123 0 0
Leukotriene receptors R-HSA-391906 7.536495e-01 0.123 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.537814e-01 0.123 0 0
Interaction between L1 and Ankyrins R-HSA-445095 7.537814e-01 0.123 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 7.537814e-01 0.123 0 0
Packaging Of Telomere Ends R-HSA-171306 7.537814e-01 0.123 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 7.537814e-01 0.123 0 0
Signaling by FGFR3 in disease R-HSA-5655332 7.537814e-01 0.123 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 7.537814e-01 0.123 0 0
Maturation of hRSV A proteins R-HSA-9828806 7.537814e-01 0.123 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.541715e-01 0.123 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 7.556635e-01 0.122 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 7.556635e-01 0.122 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 7.556635e-01 0.122 0 0
Potential therapeutics for SARS R-HSA-9679191 7.583461e-01 0.120 0 0
Signaling by PDGF R-HSA-186797 7.590080e-01 0.120 0 0
HIV Life Cycle R-HSA-162587 7.593934e-01 0.120 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 7.630176e-01 0.117 0 0
Toll-like Receptor Cascades R-HSA-168898 7.652119e-01 0.116 0 0
GPER1 signaling R-HSA-9634597 7.664757e-01 0.116 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 7.664757e-01 0.116 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 7.688253e-01 0.114 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.688253e-01 0.114 0 0
Signalling to RAS R-HSA-167044 7.688253e-01 0.114 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.688253e-01 0.114 0 0
Basigin interactions R-HSA-210991 7.688253e-01 0.114 0 0
Early Phase of HIV Life Cycle R-HSA-162594 7.688253e-01 0.114 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 7.688253e-01 0.114 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 7.693003e-01 0.114 0 0
CRMPs in Sema3A signaling R-HSA-399956 7.693003e-01 0.114 0 0
Physiological factors R-HSA-5578768 7.693003e-01 0.114 0 0
Non-canonical inflammasome activation R-HSA-9686114 7.693003e-01 0.114 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 7.693003e-01 0.114 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 7.693003e-01 0.114 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 7.701501e-01 0.113 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 7.724269e-01 0.112 0 0
Degradation of CRY and PER proteins R-HSA-9932298 7.724269e-01 0.112 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 7.729483e-01 0.112 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 7.737979e-01 0.111 0 0
Formation of the Early Elongation Complex R-HSA-113418 7.737979e-01 0.111 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 7.747303e-01 0.111 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 7.766811e-01 0.110 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 7.807102e-01 0.108 0 0
Degradation of CDH1 R-HSA-9766229 7.816529e-01 0.107 0 0
HIV Infection R-HSA-162906 7.863219e-01 0.104 0 0
GABA B receptor activation R-HSA-977444 7.883143e-01 0.103 0 0
Activation of GABAB receptors R-HSA-991365 7.883143e-01 0.103 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 7.883143e-01 0.103 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 7.883143e-01 0.103 0 0
Depyrimidination R-HSA-73928 7.883143e-01 0.103 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 7.891725e-01 0.103 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 7.891725e-01 0.103 0 0
Netrin mediated repulsion signals R-HSA-418886 7.891725e-01 0.103 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 7.891725e-01 0.103 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.891725e-01 0.103 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 7.891725e-01 0.103 0 0
Disinhibition of SNARE formation R-HSA-114516 7.891725e-01 0.103 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 7.891725e-01 0.103 0 0
DAG1 core M1 glycosylations R-HSA-8932506 7.891725e-01 0.103 0 0
mRNA Editing: C to U Conversion R-HSA-72200 7.891725e-01 0.103 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.891725e-01 0.103 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 7.891725e-01 0.103 0 0
VLDL clearance R-HSA-8964046 7.891725e-01 0.103 0 0
Activation of TRKA receptors R-HSA-187015 7.891725e-01 0.103 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 7.891725e-01 0.103 0 0
Glycoprotein hormones R-HSA-209822 7.891725e-01 0.103 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 7.891725e-01 0.103 0 0
Neutrophil degranulation R-HSA-6798695 7.894620e-01 0.103 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 7.901718e-01 0.102 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.902474e-01 0.102 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.902474e-01 0.102 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 7.902474e-01 0.102 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.924580e-01 0.101 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 7.925091e-01 0.101 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 7.925091e-01 0.101 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 7.944895e-01 0.100 0 0
Translesion synthesis by REV1 R-HSA-110312 7.944895e-01 0.100 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 7.944895e-01 0.100 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 7.944895e-01 0.100 0 0
Telomere C-strand synthesis initiation R-HSA-174430 7.944895e-01 0.100 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 7.944895e-01 0.100 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 7.944895e-01 0.100 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 7.944895e-01 0.100 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 7.973648e-01 0.098 0 0
Regulation of insulin secretion R-HSA-422356 7.975685e-01 0.098 0 0
Cellular response to hypoxia R-HSA-1234174 7.990709e-01 0.097 0 0
Signaling by Insulin receptor R-HSA-74752 7.992244e-01 0.097 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.037724e-01 0.095 0 0
Inositol phosphate metabolism R-HSA-1483249 8.049510e-01 0.094 0 0
SARS-CoV Infections R-HSA-9679506 8.083311e-01 0.092 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.099557e-01 0.092 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.099912e-01 0.092 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.099912e-01 0.092 0 0
Notch-HLH transcription pathway R-HSA-350054 8.099912e-01 0.092 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 8.099912e-01 0.092 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 8.099912e-01 0.092 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 8.099912e-01 0.092 0 0
Late Phase of HIV Life Cycle R-HSA-162599 8.105437e-01 0.091 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.109261e-01 0.091 0 0
Degradation of AXIN R-HSA-4641257 8.130075e-01 0.090 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.130075e-01 0.090 0 0
Voltage gated Potassium channels R-HSA-1296072 8.130075e-01 0.090 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 8.130075e-01 0.090 0 0
Cleavage of the damaged purine R-HSA-110331 8.130075e-01 0.090 0 0
Extension of Telomeres R-HSA-180786 8.163518e-01 0.088 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.172132e-01 0.088 0 0
Translesion synthesis by POLI R-HSA-5656121 8.172132e-01 0.088 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 8.172132e-01 0.088 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.172132e-01 0.088 0 0
Attachment and Entry R-HSA-9678110 8.172132e-01 0.088 0 0
Regulation of BACH1 activity R-HSA-9708530 8.172132e-01 0.088 0 0
Negative regulation of FLT3 R-HSA-9706369 8.172132e-01 0.088 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 8.172132e-01 0.088 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 8.172132e-01 0.088 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 8.195750e-01 0.086 0 0
DAG1 core M2 glycosylations R-HSA-8932504 8.195750e-01 0.086 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 8.195750e-01 0.086 0 0
FGFR1b ligand binding and activation R-HSA-190370 8.195750e-01 0.086 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 8.195750e-01 0.086 0 0
Interleukin-9 signaling R-HSA-8985947 8.195750e-01 0.086 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 8.195750e-01 0.086 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 8.195750e-01 0.086 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 8.195750e-01 0.086 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 8.195750e-01 0.086 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 8.195750e-01 0.086 0 0
Alpha-defensins R-HSA-1462054 8.195750e-01 0.086 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 8.195750e-01 0.086 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 8.227528e-01 0.085 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 8.227528e-01 0.085 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.227528e-01 0.085 0 0
Synthesis of DNA R-HSA-69239 8.249414e-01 0.084 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.261844e-01 0.083 0 0
Budding and maturation of HIV virion R-HSA-162588 8.261844e-01 0.083 0 0
Cargo concentration in the ER R-HSA-5694530 8.261844e-01 0.083 0 0
Depurination R-HSA-73927 8.276685e-01 0.082 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 8.281398e-01 0.082 0 0
Formation of the ureteric bud R-HSA-9830674 8.281398e-01 0.082 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 8.281398e-01 0.082 0 0
Transmission across Chemical Synapses R-HSA-112315 8.289942e-01 0.081 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.293020e-01 0.081 0 0
Protein ubiquitination R-HSA-8852135 8.293020e-01 0.081 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 8.308886e-01 0.080 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 8.308886e-01 0.080 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 8.308886e-01 0.080 0 0
Co-inhibition by PD-1 R-HSA-389948 8.318677e-01 0.080 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 8.338024e-01 0.079 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 8.339593e-01 0.079 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 8.350238e-01 0.078 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 8.360026e-01 0.078 0 0
Platelet degranulation R-HSA-114608 8.372102e-01 0.077 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 8.376587e-01 0.077 0 0
Translesion synthesis by POLK R-HSA-5655862 8.376587e-01 0.077 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 8.376587e-01 0.077 0 0
Passive transport by Aquaporins R-HSA-432047 8.376587e-01 0.077 0 0
Synthesis of PG R-HSA-1483148 8.376587e-01 0.077 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 8.396013e-01 0.076 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 8.413816e-01 0.075 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 8.434563e-01 0.074 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 8.434563e-01 0.074 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.447808e-01 0.073 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 8.455947e-01 0.073 0 0
Interleukin-21 signaling R-HSA-9020958 8.455947e-01 0.073 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 8.455947e-01 0.073 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 8.455947e-01 0.073 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 8.455947e-01 0.073 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 8.455947e-01 0.073 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 8.455947e-01 0.073 0 0
Regulation of signaling by NODAL R-HSA-1433617 8.455947e-01 0.073 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 8.455947e-01 0.073 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 8.455947e-01 0.073 0 0
Lysosomal oligosaccharide catabolism R-HSA-8853383 8.455947e-01 0.073 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.455947e-01 0.073 0 0
Cellular response to mitochondrial stress R-HSA-9840373 8.455947e-01 0.073 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 8.466101e-01 0.072 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 8.466101e-01 0.072 0 0
COPI-mediated anterograde transport R-HSA-6807878 8.473843e-01 0.072 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 8.503738e-01 0.070 0 0
MHC class II antigen presentation R-HSA-2132295 8.541518e-01 0.068 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.541831e-01 0.068 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 8.551947e-01 0.068 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 8.552547e-01 0.068 0 0
Telomere Maintenance R-HSA-157579 8.558554e-01 0.068 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.560103e-01 0.068 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.560103e-01 0.068 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.560103e-01 0.068 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 8.575326e-01 0.067 0 0
RNA Polymerase I Transcription R-HSA-73864 8.587437e-01 0.066 0 0
PCP/CE pathway R-HSA-4086400 8.587437e-01 0.066 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.600043e-01 0.065 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.600043e-01 0.065 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 8.600043e-01 0.065 0 0
Signaling by FGFR R-HSA-190236 8.639557e-01 0.064 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.661116e-01 0.062 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.661116e-01 0.062 0 0
Maturation of spike protein R-HSA-9694548 8.661116e-01 0.062 0 0
Metal ion SLC transporters R-HSA-425410 8.663121e-01 0.062 0 0
Signaling by NOTCH R-HSA-157118 8.666208e-01 0.062 0 0
MAPK3 (ERK1) activation R-HSA-110056 8.678633e-01 0.062 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.678633e-01 0.062 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 8.678633e-01 0.062 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.678633e-01 0.062 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 8.678633e-01 0.062 0 0
Maturation of spike protein R-HSA-9683686 8.678633e-01 0.062 0 0
Sperm Motility And Taxes R-HSA-1300642 8.678633e-01 0.062 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 8.678633e-01 0.062 0 0
Peptide hormone biosynthesis R-HSA-209952 8.678633e-01 0.062 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.678633e-01 0.062 0 0
Josephin domain DUBs R-HSA-5689877 8.678633e-01 0.062 0 0
Vpu mediated degradation of CD4 R-HSA-180534 8.680862e-01 0.061 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.680862e-01 0.061 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 8.680862e-01 0.061 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.680862e-01 0.061 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 8.724467e-01 0.059 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 8.724467e-01 0.059 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 8.731101e-01 0.059 0 0
Adipogenesis R-HSA-9843745 8.732570e-01 0.059 0 0
Metalloprotease DUBs R-HSA-5689901 8.739009e-01 0.059 0 0
Signaling by MET R-HSA-6806834 8.760246e-01 0.057 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.772066e-01 0.057 0 0
HIV Transcription Initiation R-HSA-167161 8.772066e-01 0.057 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.772066e-01 0.057 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.772066e-01 0.057 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.772066e-01 0.057 0 0
Intra-Golgi traffic R-HSA-6811438 8.772066e-01 0.057 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.772066e-01 0.057 0 0
Regulation of CDH1 Function R-HSA-9764561 8.774757e-01 0.057 0 0
Interferon gamma signaling R-HSA-877300 8.793607e-01 0.056 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.799778e-01 0.056 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.799778e-01 0.056 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 8.799778e-01 0.056 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.799778e-01 0.056 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.799778e-01 0.056 0 0
Mitophagy R-HSA-5205647 8.799778e-01 0.056 0 0
Signaling by NOTCH2 R-HSA-1980145 8.799778e-01 0.056 0 0
Gene Silencing by RNA R-HSA-211000 8.828784e-01 0.054 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.863235e-01 0.052 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.865606e-01 0.052 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.865606e-01 0.052 0 0
Cristae formation R-HSA-8949613 8.865606e-01 0.052 0 0
DAG1 core M3 glycosylations R-HSA-8932505 8.869214e-01 0.052 0 0
FGFR2b ligand binding and activation R-HSA-190377 8.869214e-01 0.052 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.869214e-01 0.052 0 0
vRNP Assembly R-HSA-192905 8.869214e-01 0.052 0 0
Synthesis of PI R-HSA-1483226 8.869214e-01 0.052 0 0
Transport of RCbl within the body R-HSA-9758890 8.869214e-01 0.052 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.869214e-01 0.052 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 8.869214e-01 0.052 0 0
LGI-ADAM interactions R-HSA-5682910 8.869214e-01 0.052 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 8.869214e-01 0.052 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 8.869214e-01 0.052 0 0
Suppression of apoptosis R-HSA-9635465 8.869214e-01 0.052 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 8.871384e-01 0.052 0 0
Translesion Synthesis by POLH R-HSA-110320 8.871384e-01 0.052 0 0
E2F mediated regulation of DNA replication R-HSA-113510 8.871384e-01 0.052 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.871384e-01 0.052 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 8.875088e-01 0.052 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.879812e-01 0.052 0 0
Regulation of beta-cell development R-HSA-186712 8.950415e-01 0.048 0 0
Hedgehog ligand biogenesis R-HSA-5358346 8.953391e-01 0.048 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.953472e-01 0.048 0 0
Kidney development R-HSA-9830369 8.956875e-01 0.048 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 8.969714e-01 0.047 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.970591e-01 0.047 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 8.970591e-01 0.047 0 0
Defective pyroptosis R-HSA-9710421 8.970591e-01 0.047 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.980716e-01 0.047 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 8.980716e-01 0.047 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.980716e-01 0.047 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 8.980716e-01 0.047 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.002467e-01 0.046 0 0
Negative regulation of MET activity R-HSA-6807004 9.002467e-01 0.046 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.009904e-01 0.045 0 0
RUNX2 regulates bone development R-HSA-8941326 9.009904e-01 0.045 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 9.032317e-01 0.044 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 9.032317e-01 0.044 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 9.032317e-01 0.044 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 9.032317e-01 0.044 0 0
Plasmalogen biosynthesis R-HSA-75896 9.032317e-01 0.044 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 9.032317e-01 0.044 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 9.032317e-01 0.044 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 9.032317e-01 0.044 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.037362e-01 0.044 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.037362e-01 0.044 0 0
UCH proteinases R-HSA-5689603 9.040937e-01 0.044 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 9.052667e-01 0.043 0 0
Proteasome assembly R-HSA-9907900 9.058985e-01 0.043 0 0
Termination of translesion DNA synthesis R-HSA-5656169 9.085192e-01 0.042 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.102246e-01 0.041 0 0
Viral Messenger RNA Synthesis R-HSA-168325 9.104277e-01 0.041 0 0
Aquaporin-mediated transport R-HSA-445717 9.104277e-01 0.041 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.115461e-01 0.040 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.115461e-01 0.040 0 0
Smooth Muscle Contraction R-HSA-445355 9.115461e-01 0.040 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 9.119227e-01 0.040 0 0
Lagging Strand Synthesis R-HSA-69186 9.119227e-01 0.040 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.119227e-01 0.040 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.140675e-01 0.039 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.140675e-01 0.039 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.140675e-01 0.039 0 0
Leading Strand Synthesis R-HSA-69109 9.171902e-01 0.038 0 0
Polymerase switching R-HSA-69091 9.171902e-01 0.038 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 9.171902e-01 0.038 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 9.171902e-01 0.038 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 9.171902e-01 0.038 0 0
Synthesis of GDP-mannose R-HSA-446205 9.171902e-01 0.038 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 9.171902e-01 0.038 0 0
Estrogen biosynthesis R-HSA-193144 9.171902e-01 0.038 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 9.171902e-01 0.038 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 9.179858e-01 0.037 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.179858e-01 0.037 0 0
Platelet homeostasis R-HSA-418346 9.216727e-01 0.035 0 0
Attachment and Entry R-HSA-9694614 9.223068e-01 0.035 0 0
DNA Replication R-HSA-69306 9.224006e-01 0.035 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.242446e-01 0.034 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.255285e-01 0.034 0 0
Signaling by NOTCH3 R-HSA-9012852 9.255285e-01 0.034 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 9.264225e-01 0.033 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.264225e-01 0.033 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.265497e-01 0.033 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 9.265497e-01 0.033 0 0
Cilium Assembly R-HSA-5617833 9.265548e-01 0.033 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 9.288750e-01 0.032 0 0
Adenylate cyclase activating pathway R-HSA-170660 9.291359e-01 0.032 0 0
FGFR2c ligand binding and activation R-HSA-190375 9.291359e-01 0.032 0 0
FGFR1c ligand binding and activation R-HSA-190373 9.291359e-01 0.032 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 9.291359e-01 0.032 0 0
FGFR4 ligand binding and activation R-HSA-190322 9.291359e-01 0.032 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 9.291359e-01 0.032 0 0
Chylomicron remodeling R-HSA-8963901 9.291359e-01 0.032 0 0
Mtb iron assimilation by chelation R-HSA-1222449 9.291359e-01 0.032 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 9.291359e-01 0.032 0 0
FGFR3 mutant receptor activation R-HSA-2033514 9.291359e-01 0.032 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 9.291359e-01 0.032 0 0
Interleukin-6 signaling R-HSA-1059683 9.291359e-01 0.032 0 0
Organelle biogenesis and maintenance R-HSA-1852241 9.298094e-01 0.032 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.315285e-01 0.031 0 0
Signaling by KIT in disease R-HSA-9669938 9.315285e-01 0.031 0 0
Adaptive Immune System R-HSA-1280218 9.338289e-01 0.030 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.342854e-01 0.030 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 9.381304e-01 0.028 0 0
ER-Phagosome pathway R-HSA-1236974 9.384415e-01 0.028 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 9.393590e-01 0.027 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 9.393590e-01 0.027 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 9.393590e-01 0.027 0 0
FGFR3c ligand binding and activation R-HSA-190372 9.393590e-01 0.027 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 9.393590e-01 0.027 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 9.393590e-01 0.027 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 9.393590e-01 0.027 0 0
Removal of the Flap Intermediate R-HSA-69166 9.393590e-01 0.027 0 0
Prolactin receptor signaling R-HSA-1170546 9.393590e-01 0.027 0 0
Malate-aspartate shuttle R-HSA-9856872 9.393590e-01 0.027 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.393590e-01 0.027 0 0
Ciprofloxacin ADME R-HSA-9793528 9.393590e-01 0.027 0 0
Signal regulatory protein family interactions R-HSA-391160 9.393590e-01 0.027 0 0
P2Y receptors R-HSA-417957 9.393590e-01 0.027 0 0
Zinc transporters R-HSA-435354 9.393590e-01 0.027 0 0
Growth hormone receptor signaling R-HSA-982772 9.397072e-01 0.027 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.399377e-01 0.027 0 0
DNA Damage Bypass R-HSA-73893 9.408202e-01 0.026 0 0
Base Excision Repair R-HSA-73884 9.428380e-01 0.026 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.431932e-01 0.025 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.447682e-01 0.025 0 0
Translation of Structural Proteins R-HSA-9683701 9.458102e-01 0.024 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.469518e-01 0.024 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.469518e-01 0.024 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.469518e-01 0.024 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.475478e-01 0.023 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 9.481078e-01 0.023 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 9.481078e-01 0.023 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.481078e-01 0.023 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 9.481078e-01 0.023 0 0
Signaling by Activin R-HSA-1502540 9.481078e-01 0.023 0 0
p38MAPK events R-HSA-171007 9.481078e-01 0.023 0 0
Biotin transport and metabolism R-HSA-196780 9.481078e-01 0.023 0 0
FGFR3 ligand binding and activation R-HSA-190239 9.481078e-01 0.023 0 0
Events associated with phagocytolytic activity of PMN cells R-HSA-8941413 9.481078e-01 0.023 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 9.481078e-01 0.023 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 9.481078e-01 0.023 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.481078e-01 0.023 0 0
Processive synthesis on the lagging strand R-HSA-69183 9.481078e-01 0.023 0 0
DNA Damage Reversal R-HSA-73942 9.481078e-01 0.023 0 0
Nucleotide Excision Repair R-HSA-5696398 9.506007e-01 0.022 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.511569e-01 0.022 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 9.522708e-01 0.021 0 0
Translation of Structural Proteins R-HSA-9694635 9.524749e-01 0.021 0 0
eNOS activation R-HSA-203615 9.532018e-01 0.021 0 0
Laminin interactions R-HSA-3000157 9.533615e-01 0.021 0 0
Hyaluronan degradation R-HSA-2160916 9.533615e-01 0.021 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.533615e-01 0.021 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.544216e-01 0.020 0 0
Neddylation R-HSA-8951664 9.553901e-01 0.020 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.555948e-01 0.020 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.555948e-01 0.020 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 9.555948e-01 0.020 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.555948e-01 0.020 0 0
Activation of SMO R-HSA-5635838 9.555948e-01 0.020 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 9.555948e-01 0.020 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 9.555948e-01 0.020 0 0
Synthesis of wybutosine at G37 of tRNA(Phe) R-HSA-6782861 9.555948e-01 0.020 0 0
Atorvastatin ADME R-HSA-9754706 9.555948e-01 0.020 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.564875e-01 0.019 0 0
COPII-mediated vesicle transport R-HSA-204005 9.579427e-01 0.019 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.582818e-01 0.019 0 0
Regulation of Apoptosis R-HSA-169911 9.582818e-01 0.019 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 9.590265e-01 0.018 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.590265e-01 0.018 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.590265e-01 0.018 0 0
Abacavir ADME R-HSA-2161522 9.590265e-01 0.018 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.597655e-01 0.018 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.601667e-01 0.018 0 0
tRNA processing in the nucleus R-HSA-6784531 9.603294e-01 0.018 0 0
Surfactant metabolism R-HSA-5683826 9.604120e-01 0.018 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.614845e-01 0.017 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.620019e-01 0.017 0 0
Vitamin B6 activation to pyridoxal phosphate R-HSA-964975 9.620019e-01 0.017 0 0
Phase 2 - plateau phase R-HSA-5576893 9.620019e-01 0.017 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.620019e-01 0.017 0 0
Coenzyme A biosynthesis R-HSA-196783 9.620019e-01 0.017 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.620019e-01 0.017 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.628409e-01 0.016 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.640280e-01 0.016 0 0
Signaling by BMP R-HSA-201451 9.640280e-01 0.016 0 0
Insulin processing R-HSA-264876 9.640280e-01 0.016 0 0
Somitogenesis R-HSA-9824272 9.644054e-01 0.016 0 0
Developmental Cell Lineages R-HSA-9734767 9.651419e-01 0.015 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.657328e-01 0.015 0 0
Amyloid fiber formation R-HSA-977225 9.660347e-01 0.015 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.664503e-01 0.015 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.669278e-01 0.015 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.674849e-01 0.014 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.674849e-01 0.014 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 9.674849e-01 0.014 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 9.674849e-01 0.014 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.674849e-01 0.014 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.674849e-01 0.014 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.674849e-01 0.014 0 0
Choline catabolism R-HSA-6798163 9.674849e-01 0.014 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.680213e-01 0.014 0 0
Insulin receptor recycling R-HSA-77387 9.684397e-01 0.014 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.684397e-01 0.014 0 0
Pyrimidine salvage R-HSA-73614 9.684397e-01 0.014 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 9.684397e-01 0.014 0 0
Phospholipid metabolism R-HSA-1483257 9.690183e-01 0.014 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.705875e-01 0.013 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.705875e-01 0.013 0 0
Vesicle-mediated transport R-HSA-5653656 9.706317e-01 0.013 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.712921e-01 0.013 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.721264e-01 0.012 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.721770e-01 0.012 0 0
Activated point mutants of FGFR2 R-HSA-2033519 9.721770e-01 0.012 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.721770e-01 0.012 0 0
Mismatch Repair R-HSA-5358508 9.721770e-01 0.012 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.721770e-01 0.012 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.721770e-01 0.012 0 0
Platelet sensitization by LDL R-HSA-432142 9.721770e-01 0.012 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.721770e-01 0.012 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.721770e-01 0.012 0 0
mRNA Capping R-HSA-72086 9.723275e-01 0.012 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.723275e-01 0.012 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.723275e-01 0.012 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.727981e-01 0.012 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.737901e-01 0.012 0 0
Pentose phosphate pathway R-HSA-71336 9.738614e-01 0.012 0 0
Intraflagellar transport R-HSA-5620924 9.742476e-01 0.011 0 0
Neurotransmitter clearance R-HSA-112311 9.757507e-01 0.011 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.761922e-01 0.010 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.761922e-01 0.010 0 0
Diseases of hemostasis R-HSA-9671793 9.761922e-01 0.010 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.761922e-01 0.010 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.761922e-01 0.010 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 9.767872e-01 0.010 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 9.767872e-01 0.010 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.787625e-01 0.009 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.787625e-01 0.009 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.787625e-01 0.009 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.787625e-01 0.009 0 0
Integrin cell surface interactions R-HSA-216083 9.796024e-01 0.009 0 0
ABC transporter disorders R-HSA-5619084 9.796024e-01 0.009 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.796282e-01 0.009 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.796282e-01 0.009 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.796282e-01 0.009 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.796282e-01 0.009 0 0
Pregnenolone biosynthesis R-HSA-196108 9.796282e-01 0.009 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.796282e-01 0.009 0 0
The phototransduction cascade R-HSA-2514856 9.814900e-01 0.008 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.825684e-01 0.008 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.825684e-01 0.008 0 0
G-protein activation R-HSA-202040 9.825684e-01 0.008 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.825684e-01 0.008 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.825684e-01 0.008 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.825684e-01 0.008 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.825684e-01 0.008 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.825684e-01 0.008 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.825684e-01 0.008 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.829609e-01 0.007 0 0
PKR-mediated signaling R-HSA-9833482 9.830914e-01 0.007 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.837363e-01 0.007 0 0
Hemostasis R-HSA-109582 9.837661e-01 0.007 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.839371e-01 0.007 0 0
Interferon Signaling R-HSA-913531 9.849803e-01 0.007 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 9.850845e-01 0.007 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.850845e-01 0.007 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.850845e-01 0.007 0 0
Assembly Of The HIV Virion R-HSA-175474 9.850845e-01 0.007 0 0
Serine metabolism R-HSA-977347 9.850845e-01 0.007 0 0
Glutathione synthesis and recycling R-HSA-174403 9.850845e-01 0.007 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.857784e-01 0.006 0 0
Heme degradation R-HSA-189483 9.857784e-01 0.006 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.872375e-01 0.006 0 0
Cellular hexose transport R-HSA-189200 9.872375e-01 0.006 0 0
Ethanol oxidation R-HSA-71384 9.872375e-01 0.006 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.872375e-01 0.006 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.872375e-01 0.006 0 0
LDL clearance R-HSA-8964038 9.872375e-01 0.006 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.872974e-01 0.006 0 0
Hyaluronan metabolism R-HSA-2142845 9.875699e-01 0.005 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.875699e-01 0.005 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.875699e-01 0.005 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.890798e-01 0.005 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.890798e-01 0.005 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.890798e-01 0.005 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.890798e-01 0.005 0 0
Carnitine shuttle R-HSA-200425 9.890798e-01 0.005 0 0
Biosynthesis of maresins R-HSA-9018682 9.890798e-01 0.005 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.891407e-01 0.005 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 9.894635e-01 0.005 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.894635e-01 0.005 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.900666e-01 0.004 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.900666e-01 0.004 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.905171e-01 0.004 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 9.906563e-01 0.004 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.906563e-01 0.004 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.906563e-01 0.004 0 0
Interleukin-6 family signaling R-HSA-6783589 9.906563e-01 0.004 0 0
Synthesis of PC R-HSA-1483191 9.912212e-01 0.004 0 0
Leishmania infection R-HSA-9658195 9.913255e-01 0.004 0 0
Parasitic Infection Pathways R-HSA-9824443 9.913255e-01 0.004 0 0
Parasite infection R-HSA-9664407 9.916096e-01 0.004 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.916096e-01 0.004 0 0
Leishmania phagocytosis R-HSA-9664417 9.916096e-01 0.004 0 0
Dual incision in TC-NER R-HSA-6782135 9.916248e-01 0.004 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.917225e-01 0.004 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.917225e-01 0.004 0 0
Lysine catabolism R-HSA-71064 9.917225e-01 0.004 0 0
Metabolism of folate and pterines R-HSA-196757 9.917225e-01 0.004 0 0
HCMV Early Events R-HSA-9609690 9.917643e-01 0.004 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.920052e-01 0.003 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.920052e-01 0.003 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.920052e-01 0.003 0 0
Fertilization R-HSA-1187000 9.920052e-01 0.003 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.920052e-01 0.003 0 0
Gluconeogenesis R-HSA-70263 9.922457e-01 0.003 0 0
Peroxisomal protein import R-HSA-9033241 9.925393e-01 0.003 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.925393e-01 0.003 0 0
Elastic fibre formation R-HSA-1566948 9.927777e-01 0.003 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.931540e-01 0.003 0 0
MET activates PTK2 signaling R-HSA-8874081 9.931595e-01 0.003 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.931595e-01 0.003 0 0
Sphingolipid catabolism R-HSA-9845614 9.931595e-01 0.003 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.931595e-01 0.003 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.933575e-01 0.003 0 0
Collagen degradation R-HSA-1442490 9.940891e-01 0.003 0 0
G alpha (q) signalling events R-HSA-416476 9.941364e-01 0.003 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.941472e-01 0.003 0 0
Triglyceride biosynthesis R-HSA-75109 9.941472e-01 0.003 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.941472e-01 0.003 0 0
Synthesis of PE R-HSA-1483213 9.941472e-01 0.003 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.945079e-01 0.002 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.945079e-01 0.002 0 0
Prednisone ADME R-HSA-9757110 9.949923e-01 0.002 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.953423e-01 0.002 0 0
Interferon alpha/beta signaling R-HSA-909733 9.953423e-01 0.002 0 0
PPARA activates gene expression R-HSA-1989781 9.953855e-01 0.002 0 0
ABC-family proteins mediated transport R-HSA-382556 9.955211e-01 0.002 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.956316e-01 0.002 0 0
Thyroxine biosynthesis R-HSA-209968 9.957154e-01 0.002 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.957154e-01 0.002 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.957154e-01 0.002 0 0
Glucagon-type ligand receptors R-HSA-420092 9.957154e-01 0.002 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.957372e-01 0.002 0 0
Viral Infection Pathways R-HSA-9824446 9.958845e-01 0.002 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.960746e-01 0.002 0 0
HCMV Late Events R-HSA-9610379 9.960746e-01 0.002 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.960944e-01 0.002 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.963342e-01 0.002 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.963677e-01 0.002 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.963677e-01 0.002 0 0
GPCR downstream signalling R-HSA-388396 9.964468e-01 0.002 0 0
Mitochondrial protein degradation R-HSA-9837999 9.965279e-01 0.002 0 0
Collagen formation R-HSA-1474290 9.965279e-01 0.002 0 0
G alpha (z) signalling events R-HSA-418597 9.967900e-01 0.001 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.968375e-01 0.001 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.968636e-01 0.001 0 0
HCMV Infection R-HSA-9609646 9.969591e-01 0.001 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.971481e-01 0.001 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.971750e-01 0.001 0 0
RSV-host interactions R-HSA-9833110 9.972726e-01 0.001 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.973029e-01 0.001 0 0
DAG1 glycosylations R-HSA-8931838 9.973166e-01 0.001 0 0
G alpha (s) signalling events R-HSA-418555 9.976661e-01 0.001 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.979379e-01 0.001 0 0
Neurotransmitter release cycle R-HSA-112310 9.979436e-01 0.001 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.981880e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.982074e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.982074e-01 0.001 0 0
SLC transporter disorders R-HSA-5619102 9.982918e-01 0.001 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.983120e-01 0.001 0 0
Metabolism of polyamines R-HSA-351202 9.983120e-01 0.001 0 0
Dual Incision in GG-NER R-HSA-5696400 9.983195e-01 0.001 0 0
Signal amplification R-HSA-392518 9.983195e-01 0.001 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.983195e-01 0.001 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.984129e-01 0.001 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.984247e-01 0.001 0 0
Immune System R-HSA-168256 9.984400e-01 0.001 0 0
Protein folding R-HSA-391251 9.985230e-01 0.001 0 0
PERK regulates gene expression R-HSA-381042 9.985623e-01 0.001 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.985623e-01 0.001 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.985623e-01 0.001 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.985623e-01 0.001 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.986308e-01 0.001 0 0
Mitochondrial protein import R-HSA-1268020 9.986980e-01 0.001 0 0
Glycosphingolipid transport R-HSA-9845576 9.987700e-01 0.001 0 0
NCAM1 interactions R-HSA-419037 9.989477e-01 0.000 0 0
Collagen chain trimerization R-HSA-8948216 9.989477e-01 0.000 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.992298e-01 0.000 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.992298e-01 0.000 0 0
RAS processing R-HSA-9648002 9.992298e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.992415e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.993238e-01 0.000 0 0
Tryptophan catabolism R-HSA-71240 9.993411e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.994074e-01 0.000 0 0
Protein localization R-HSA-9609507 9.994863e-01 0.000 0 0
Heme biosynthesis R-HSA-189451 9.995178e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.995579e-01 0.000 0 0
Synthesis of PA R-HSA-1483166 9.995579e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.995939e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.996018e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.996451e-01 0.000 0 0
Defensins R-HSA-1461973 9.996471e-01 0.000 0 0
Pyrimidine catabolism R-HSA-73621 9.996471e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.996675e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.996942e-01 0.000 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.996981e-01 0.000 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.996981e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.997095e-01 0.000 0 0
tRNA Aminoacylation R-HSA-379724 9.997117e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.997229e-01 0.000 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.997418e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.997501e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.997844e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.998150e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.998441e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.998450e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.998574e-01 0.000 0 0
Gap junction trafficking and regulation R-HSA-157858 9.998617e-01 0.000 0 0
Azathioprine ADME R-HSA-9748787 9.998817e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.998943e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.998943e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.998950e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.998988e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.999085e-01 0.000 0 0
tRNA processing R-HSA-72306 9.999129e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.999170e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.999315e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.999407e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999407e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999414e-01 0.000 0 0
Paracetamol ADME R-HSA-9753281 9.999458e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999477e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999487e-01 0.000 0 0
Digestion R-HSA-8935690 9.999537e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.999541e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999651e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.999668e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.999752e-01 0.000 0 0
Translation R-HSA-72766 9.999834e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999845e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999849e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999861e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.999867e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999887e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999911e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999917e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999936e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999948e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999950e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999968e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999968e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999975e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999987e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999990e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999991e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999991e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999993e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999993e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999994e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999994e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999995e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999995e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999996e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999997e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999998e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999999e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999999e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000e+00 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Axon guidance R-HSA-422475 6.169509e-13 12.210 0 0
Cellular responses to stimuli R-HSA-8953897 4.951595e-13 12.305 0 0
Nervous system development R-HSA-9675108 4.832801e-12 11.316 0 0
Cellular responses to stress R-HSA-2262752 6.704193e-12 11.174 0 0
Cell Cycle R-HSA-1640170 1.276490e-11 10.894 0 0
Cell Cycle, Mitotic R-HSA-69278 2.675948e-11 10.573 0 0
Signal Transduction R-HSA-162582 7.186451e-11 10.143 0 0
M Phase R-HSA-68886 1.687680e-10 9.773 0 0
Signaling by ROBO receptors R-HSA-376176 8.921037e-10 9.050 0 0
Cell Cycle Checkpoints R-HSA-69620 4.299341e-09 8.367 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 6.678071e-09 8.175 0 0
Cellular Senescence R-HSA-2559583 1.215114e-08 7.915 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.045515e-07 6.981 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.155348e-07 6.937 0 0
Apoptotic execution phase R-HSA-75153 1.415781e-07 6.849 0 0
Separation of Sister Chromatids R-HSA-2467813 1.731097e-07 6.762 0 0
mRNA Splicing R-HSA-72172 2.163266e-07 6.665 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 3.026562e-07 6.519 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 4.665587e-07 6.331 0 0
Mitotic Anaphase R-HSA-68882 4.831766e-07 6.316 0 0
Eukaryotic Translation Elongation R-HSA-156842 5.611873e-07 6.251 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 5.493357e-07 6.260 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 7.131353e-07 6.147 0 0
Eukaryotic Translation Initiation R-HSA-72613 7.657670e-07 6.116 0 0
Cap-dependent Translation Initiation R-HSA-72737 7.657670e-07 6.116 0 0
Metabolism of RNA R-HSA-8953854 8.529507e-07 6.069 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 8.780723e-07 6.056 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.028254e-06 5.988 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.210668e-06 5.917 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.381304e-06 5.860 0 0
Chromatin organization R-HSA-4839726 1.361940e-06 5.866 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.729271e-06 5.762 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.805033e-06 5.744 0 0
Signaling by ERBB2 R-HSA-1227986 2.011147e-06 5.697 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.056838e-06 5.687 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 2.103343e-06 5.677 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.313282e-06 5.636 0 0
Mitotic Prometaphase R-HSA-68877 2.281650e-06 5.642 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.754641e-06 5.560 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 3.230894e-06 5.491 0 0
Formation of a pool of free 40S subunits R-HSA-72689 3.407967e-06 5.468 0 0
DNA Double Strand Break Response R-HSA-5693606 3.331850e-06 5.477 0 0
Apoptosis R-HSA-109581 3.769681e-06 5.424 0 0
Chromatin modifying enzymes R-HSA-3247509 4.209178e-06 5.376 0 0
Peptide chain elongation R-HSA-156902 4.607280e-06 5.337 0 0
G2/M Checkpoints R-HSA-69481 5.512728e-06 5.259 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 6.996582e-06 5.155 0 0
Cell-Cell communication R-HSA-1500931 7.013059e-06 5.154 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 8.061426e-06 5.094 0 0
Mitotic Prophase R-HSA-68875 9.261860e-06 5.033 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.693159e-06 5.014 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.137805e-05 4.944 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.137805e-05 4.944 0 0
Meiotic synapsis R-HSA-1221632 1.224196e-05 4.912 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.252856e-05 4.902 0 0
Translation initiation complex formation R-HSA-72649 1.549516e-05 4.810 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.949265e-05 4.710 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 2.326742e-05 4.633 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 2.442818e-05 4.612 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.539077e-05 4.595 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.617383e-05 4.582 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 3.012980e-05 4.521 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 3.054908e-05 4.515 0 0
Ribosome-associated quality control R-HSA-9948299 3.480933e-05 4.458 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.375490e-05 4.472 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.523851e-05 4.453 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.486822e-05 4.458 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 3.761986e-05 4.425 0 0
G2/M DNA damage checkpoint R-HSA-69473 4.055662e-05 4.392 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 4.381851e-05 4.358 0 0
Programmed Cell Death R-HSA-5357801 4.362720e-05 4.360 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 4.910859e-05 4.309 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 4.910859e-05 4.309 0 0
ISG15 antiviral mechanism R-HSA-1169408 4.878776e-05 4.312 0 0
Cell junction organization R-HSA-446728 4.995946e-05 4.301 0 0
Regulation of TP53 Degradation R-HSA-6804757 5.239719e-05 4.281 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 5.373959e-05 4.270 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 5.822758e-05 4.235 0 0
Death Receptor Signaling R-HSA-73887 6.390284e-05 4.194 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 6.439427e-05 4.191 0 0
Deubiquitination R-HSA-5688426 6.846210e-05 4.165 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 7.529502e-05 4.123 0 0
Ub-specific processing proteases R-HSA-5689880 7.455717e-05 4.128 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 7.529502e-05 4.123 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 7.194892e-05 4.143 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 8.511329e-05 4.070 0 0
Assembly of the pre-replicative complex R-HSA-68867 8.673318e-05 4.062 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 8.751286e-05 4.058 0 0
DNA Replication Pre-Initiation R-HSA-69002 9.603951e-05 4.018 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.086775e-04 3.964 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.182303e-04 3.927 0 0
Eukaryotic Translation Termination R-HSA-72764 1.368475e-04 3.864 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.378944e-04 3.860 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.388870e-04 3.857 0 0
Aggrephagy R-HSA-9646399 1.433508e-04 3.844 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.599880e-04 3.796 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.599880e-04 3.796 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.793535e-04 3.746 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.815295e-04 3.741 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.890275e-04 3.723 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.145805e-04 3.668 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.148108e-04 3.668 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.321600e-04 3.634 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.321600e-04 3.634 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.481967e-04 3.605 0 0
DNA methylation R-HSA-5334118 2.582639e-04 3.588 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.630893e-04 3.580 0 0
Cellular response to heat stress R-HSA-3371556 2.760719e-04 3.559 0 0
Meiosis R-HSA-1500620 2.593667e-04 3.586 0 0
Signaling by Hippo R-HSA-2028269 2.771883e-04 3.557 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.596716e-04 3.586 0 0
Glycolysis R-HSA-70171 2.792271e-04 3.554 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.793026e-04 3.554 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.824225e-04 3.549 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.874788e-04 3.541 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.874788e-04 3.541 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 3.208941e-04 3.494 0 0
Protein ubiquitination R-HSA-8852135 3.215748e-04 3.493 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.283312e-04 3.484 0 0
Selenocysteine synthesis R-HSA-2408557 3.199014e-04 3.495 0 0
Regulation of endogenous retroelements R-HSA-9842860 3.657242e-04 3.437 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 4.113699e-04 3.386 0 0
Chaperone Mediated Autophagy R-HSA-9613829 3.909282e-04 3.408 0 0
Viral mRNA Translation R-HSA-192823 4.172409e-04 3.380 0 0
EPH-Ephrin signaling R-HSA-2682334 4.123718e-04 3.385 0 0
p75NTR signals via NF-kB R-HSA-193639 4.113699e-04 3.386 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.098146e-04 3.387 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.098146e-04 3.387 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.183771e-04 3.378 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 3.951956e-04 3.403 0 0
Cell-extracellular matrix interactions R-HSA-446353 4.113699e-04 3.386 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 4.449935e-04 3.352 0 0
Diseases of programmed cell death R-HSA-9645723 4.669164e-04 3.331 0 0
Developmental Biology R-HSA-1266738 4.828037e-04 3.316 0 0
Packaging Of Telomere Ends R-HSA-171306 5.268076e-04 3.278 0 0
PRC2 methylates histones and DNA R-HSA-212300 5.581186e-04 3.253 0 0
Nucleosome assembly R-HSA-774815 5.255181e-04 3.279 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.255181e-04 3.279 0 0
Signaling by EGFR R-HSA-177929 5.536976e-04 3.257 0 0
Intracellular signaling by second messengers R-HSA-9006925 5.175710e-04 3.286 0 0
HATs acetylate histones R-HSA-3214847 5.429063e-04 3.265 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 5.268076e-04 3.278 0 0
Influenza Infection R-HSA-168255 5.171618e-04 3.286 0 0
Mitotic Spindle Checkpoint R-HSA-69618 6.179265e-04 3.209 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 6.997900e-04 3.155 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 6.997900e-04 3.155 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 7.006962e-04 3.154 0 0
Amplification of signal from the kinetochores R-HSA-141424 7.006962e-04 3.154 0 0
mRNA 3'-end processing R-HSA-72187 7.174629e-04 3.144 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 7.291097e-04 3.137 0 0
Recycling pathway of L1 R-HSA-437239 7.726516e-04 3.112 0 0
ESR-mediated signaling R-HSA-8939211 8.203743e-04 3.086 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 8.779895e-04 3.057 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 8.565001e-04 3.067 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 8.507237e-04 3.070 0 0
Adherens junctions interactions R-HSA-418990 9.229066e-04 3.035 0 0
G2/M Transition R-HSA-69275 9.804468e-04 3.009 0 0
Signaling by VEGF R-HSA-194138 1.009329e-03 2.996 0 0
Selective autophagy R-HSA-9663891 1.052436e-03 2.978 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.054144e-03 2.977 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.072089e-03 2.970 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.072089e-03 2.970 0 0
Nuclear import of Rev protein R-HSA-180746 1.092748e-03 2.961 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.092748e-03 2.961 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.102955e-03 2.957 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.244489e-03 2.905 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.244489e-03 2.905 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.244489e-03 2.905 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.244489e-03 2.905 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.244489e-03 2.905 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.244489e-03 2.905 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.244489e-03 2.905 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.244489e-03 2.905 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.244489e-03 2.905 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.244489e-03 2.905 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.244489e-03 2.905 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.141790e-03 2.942 0 0
HDACs deacetylate histones R-HSA-3214815 1.204418e-03 2.919 0 0
G alpha (12/13) signalling events R-HSA-416482 1.193685e-03 2.923 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.167055e-03 2.933 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.264803e-03 2.898 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.285598e-03 2.891 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.285598e-03 2.891 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.285598e-03 2.891 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.300355e-03 2.886 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.353546e-03 2.869 0 0
Cell-cell junction organization R-HSA-421270 1.408995e-03 2.851 0 0
NRAGE signals death through JNK R-HSA-193648 1.419135e-03 2.848 0 0
Ephrin signaling R-HSA-3928664 1.542525e-03 2.812 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.558096e-03 2.807 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.599828e-03 2.796 0 0
Meiotic recombination R-HSA-912446 1.571037e-03 2.804 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.542525e-03 2.812 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.620053e-03 2.790 0 0
Signaling by ALK in cancer R-HSA-9700206 1.620053e-03 2.790 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.654930e-03 2.781 0 0
Regulation of CDH1 Function R-HSA-9764561 1.665315e-03 2.779 0 0
DNA Replication R-HSA-69306 1.669641e-03 2.777 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.670244e-03 2.777 0 0
Homology Directed Repair R-HSA-5693538 1.678005e-03 2.775 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.692549e-03 2.771 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.722567e-03 2.764 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.731006e-03 2.762 0 0
DCC mediated attractive signaling R-HSA-418885 1.767124e-03 2.753 0 0
NF-kB is activated and signals survival R-HSA-209560 1.908652e-03 2.719 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 1.908652e-03 2.719 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.908652e-03 2.719 0 0
S Phase R-HSA-69242 1.938741e-03 2.712 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.011547e-03 2.696 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.015186e-03 2.696 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 2.015186e-03 2.696 0 0
Autophagy R-HSA-9612973 2.191597e-03 2.659 0 0
HCMV Early Events R-HSA-9609690 2.260581e-03 2.646 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.679979e-03 2.572 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.722622e-03 2.565 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.664087e-03 2.574 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.722744e-03 2.565 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.722744e-03 2.565 0 0
RNA Polymerase I Transcription R-HSA-73864 2.664087e-03 2.574 0 0
Defective pyroptosis R-HSA-9710421 2.678353e-03 2.572 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.437669e-03 2.613 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.763217e-03 2.559 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.763217e-03 2.559 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.930134e-03 2.533 0 0
Glucose metabolism R-HSA-70326 2.946082e-03 2.531 0 0
DNA Double-Strand Break Repair R-HSA-5693532 3.034495e-03 2.518 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.038935e-03 2.517 0 0
Regulation of TP53 Activity R-HSA-5633007 3.102047e-03 2.508 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 3.148555e-03 2.502 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.173692e-03 2.498 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.173692e-03 2.498 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.356910e-03 2.474 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.356910e-03 2.474 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.423795e-03 2.465 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 3.455599e-03 2.461 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 3.455599e-03 2.461 0 0
Signaling by ERBB4 R-HSA-1236394 3.481225e-03 2.458 0 0
Attenuation phase R-HSA-3371568 3.500854e-03 2.456 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.500854e-03 2.456 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 3.508468e-03 2.455 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.518928e-03 2.454 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 4.035151e-03 2.394 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.158118e-03 2.381 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.158118e-03 2.381 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 4.104468e-03 2.387 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 4.104468e-03 2.387 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 4.104468e-03 2.387 0 0
HSF1-dependent transactivation R-HSA-3371571 3.899269e-03 2.409 0 0
Oncogene Induced Senescence R-HSA-2559585 3.819437e-03 2.418 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 4.104468e-03 2.387 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 4.158600e-03 2.381 0 0
Post NMDA receptor activation events R-HSA-438064 4.229754e-03 2.374 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.925171e-03 2.406 0 0
MAPK family signaling cascades R-HSA-5683057 4.224360e-03 2.374 0 0
FLT3 Signaling R-HSA-9607240 4.158600e-03 2.381 0 0
SARS-CoV-1 Infection R-HSA-9678108 3.766449e-03 2.424 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 4.366882e-03 2.360 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 4.471513e-03 2.350 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 4.529016e-03 2.344 0 0
Signaling by Nuclear Receptors R-HSA-9006931 4.530394e-03 2.344 0 0
HSF1 activation R-HSA-3371511 4.579368e-03 2.339 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.737797e-03 2.324 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 4.914341e-03 2.309 0 0
L1CAM interactions R-HSA-373760 5.066388e-03 2.295 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 5.272073e-03 2.278 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 5.272073e-03 2.278 0 0
Cleavage of the damaged purine R-HSA-110331 5.455579e-03 2.263 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 5.498875e-03 2.260 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 5.512963e-03 2.259 0 0
mTORC1-mediated signalling R-HSA-166208 5.528011e-03 2.257 0 0
Macroautophagy R-HSA-1632852 5.648397e-03 2.248 0 0
Host Interactions of HIV factors R-HSA-162909 5.747212e-03 2.241 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 5.772600e-03 2.239 0 0
Depyrimidination R-HSA-73928 5.772600e-03 2.239 0 0
Membrane Trafficking R-HSA-199991 5.808852e-03 2.236 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 5.961914e-03 2.225 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 5.994599e-03 2.222 0 0
Regulation of PTEN gene transcription R-HSA-8943724 6.031395e-03 2.220 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 6.036524e-03 2.219 0 0
Regulation of PTEN localization R-HSA-8948747 6.233020e-03 2.205 0 0
Gene Silencing by RNA R-HSA-211000 6.240354e-03 2.205 0 0
Reproduction R-HSA-1474165 6.439521e-03 2.191 0 0
Depurination R-HSA-73927 6.460003e-03 2.190 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 6.482343e-03 2.188 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 6.512129e-03 2.186 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 6.795303e-03 2.168 0 0
PKR-mediated signaling R-HSA-9833482 7.151829e-03 2.146 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 7.151829e-03 2.146 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 7.166330e-03 2.145 0 0
Chromosome Maintenance R-HSA-73886 7.996699e-03 2.097 0 0
Telomere Maintenance R-HSA-157579 7.679213e-03 2.115 0 0
Stabilization of p53 R-HSA-69541 7.605017e-03 2.119 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 8.117879e-03 2.091 0 0
Nephrin family interactions R-HSA-373753 8.845206e-03 2.053 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 8.519136e-03 2.070 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 8.845206e-03 2.053 0 0
Cellular response to starvation R-HSA-9711097 7.950471e-03 2.100 0 0
Negative regulation of MET activity R-HSA-6807004 8.845206e-03 2.053 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 7.605017e-03 2.119 0 0
Viral Infection Pathways R-HSA-9824446 8.738354e-03 2.059 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 7.813167e-03 2.107 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 8.849897e-03 2.053 0 0
Signaling by PTK6 R-HSA-8848021 8.849897e-03 2.053 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.903380e-03 2.050 0 0
Interleukin-12 signaling R-HSA-9020591 9.305954e-03 2.031 0 0
Cytokine Signaling in Immune system R-HSA-1280215 9.614502e-03 2.017 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.670721e-03 2.015 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.002978e-02 1.999 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.036815e-02 1.984 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.036815e-02 1.984 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.047917e-02 1.980 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.089969e-02 1.963 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.106956e-02 1.956 0 0
EGFR downregulation R-HSA-182971 1.123133e-02 1.950 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.125057e-02 1.949 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.125057e-02 1.949 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.130933e-02 1.947 0 0
RET signaling R-HSA-8853659 1.177307e-02 1.929 0 0
FLT3 signaling in disease R-HSA-9682385 1.177307e-02 1.929 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.211497e-02 1.917 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.219590e-02 1.914 0 0
HIV Life Cycle R-HSA-162587 1.238524e-02 1.907 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.241919e-02 1.906 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.291533e-02 1.889 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 1.291533e-02 1.889 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.334733e-02 1.875 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.349108e-02 1.870 0 0
MTOR signalling R-HSA-165159 1.385018e-02 1.859 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.396447e-02 1.855 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.405801e-02 1.852 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.428110e-02 1.845 0 0
PTEN Regulation R-HSA-6807070 1.439580e-02 1.842 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.477214e-02 1.831 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.485757e-02 1.828 0 0
Gap junction trafficking and regulation R-HSA-157858 1.564644e-02 1.806 0 0
Amyloid fiber formation R-HSA-977225 1.576105e-02 1.802 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.578043e-02 1.802 0 0
Interleukin-12 family signaling R-HSA-447115 1.636976e-02 1.786 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.664094e-02 1.779 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.666490e-02 1.778 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.767442e-02 1.753 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.774121e-02 1.751 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.228893e-02 1.652 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.228893e-02 1.652 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.228893e-02 1.652 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.228893e-02 1.652 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.228893e-02 1.652 0 0
MET interacts with TNS proteins R-HSA-8875513 2.015695e-02 1.696 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.970624e-02 1.705 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.822314e-02 1.739 0 0
Striated Muscle Contraction R-HSA-390522 1.822314e-02 1.739 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.813315e-02 1.742 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.833120e-02 1.737 0 0
Regulation of signaling by CBL R-HSA-912631 2.165462e-02 1.664 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.950778e-02 1.710 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.226704e-02 1.652 0 0
Gap junction trafficking R-HSA-190828 1.815850e-02 1.741 0 0
Semaphorin interactions R-HSA-373755 1.845194e-02 1.734 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.045243e-02 1.689 0 0
SARS-CoV-2 Infection R-HSA-9694516 2.103117e-02 1.677 0 0
SARS-CoV Infections R-HSA-9679506 1.929320e-02 1.715 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 2.310368e-02 1.636 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.310368e-02 1.636 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 2.310368e-02 1.636 0 0
PECAM1 interactions R-HSA-210990 2.327488e-02 1.633 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.327488e-02 1.633 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.327488e-02 1.633 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 2.327488e-02 1.633 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.404739e-02 1.619 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 2.404739e-02 1.619 0 0
Metabolism of non-coding RNA R-HSA-194441 2.410379e-02 1.618 0 0
snRNP Assembly R-HSA-191859 2.410379e-02 1.618 0 0
Smooth Muscle Contraction R-HSA-445355 2.530145e-02 1.597 0 0
Interferon Signaling R-HSA-913531 2.531233e-02 1.597 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.621643e-02 1.581 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.631182e-02 1.580 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.640262e-02 1.578 0 0
Kinesins R-HSA-983189 2.682222e-02 1.572 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.733329e-02 1.563 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.733329e-02 1.563 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 2.819733e-02 1.550 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 2.828354e-02 1.548 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.861808e-02 1.543 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 2.864582e-02 1.543 0 0
HIV Infection R-HSA-162906 2.881785e-02 1.540 0 0
HCMV Infection R-HSA-9609646 2.952938e-02 1.530 0 0
Co-stimulation by CD28 R-HSA-389356 2.967683e-02 1.528 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 3.002197e-02 1.523 0 0
Activation of RAC1 R-HSA-428540 3.002197e-02 1.523 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 3.139283e-02 1.503 0 0
Basigin interactions R-HSA-210991 3.139283e-02 1.503 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 3.151425e-02 1.501 0 0
Selenoamino acid metabolism R-HSA-2408522 3.154500e-02 1.501 0 0
Signaling by Interleukins R-HSA-449147 3.162059e-02 1.500 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.193848e-02 1.496 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.193848e-02 1.496 0 0
Degradation of DVL R-HSA-4641258 3.193848e-02 1.496 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 3.207455e-02 1.494 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 3.207455e-02 1.494 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 3.248603e-02 1.488 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.253924e-02 1.488 0 0
Hedgehog 'off' state R-HSA-5610787 3.306837e-02 1.481 0 0
Signaling by WNT R-HSA-195721 3.309890e-02 1.480 0 0
Clathrin-mediated endocytosis R-HSA-8856828 3.325745e-02 1.478 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 3.499767e-02 1.456 0 0
Synthesis of DNA R-HSA-69239 3.558874e-02 1.449 0 0
Interleukin-1 signaling R-HSA-9020702 3.571202e-02 1.447 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 3.633129e-02 1.440 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 3.633129e-02 1.440 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 3.721266e-02 1.429 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.777000e-02 1.423 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 3.777000e-02 1.423 0 0
Manipulation of host energy metabolism R-HSA-9636667 4.657378e-02 1.332 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 4.692731e-02 1.329 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 4.692731e-02 1.329 0 0
Formation of annular gap junctions R-HSA-196025 3.841185e-02 1.416 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 4.989477e-02 1.302 0 0
Gap junction degradation R-HSA-190873 4.989477e-02 1.302 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 4.219138e-02 1.375 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 4.219138e-02 1.375 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 4.869095e-02 1.313 0 0
Orc1 removal from chromatin R-HSA-68949 4.571304e-02 1.340 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.571304e-02 1.340 0 0
Regulation of PTEN stability and activity R-HSA-8948751 5.050718e-02 1.297 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 5.050718e-02 1.297 0 0
AURKA Activation by TPX2 R-HSA-8854518 4.804686e-02 1.318 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 4.860274e-02 1.313 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 4.167941e-02 1.380 0 0
Co-inhibition by PD-1 R-HSA-389948 4.708762e-02 1.327 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 4.459636e-02 1.351 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 3.911300e-02 1.408 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 4.692731e-02 1.329 0 0
Netrin-1 signaling R-HSA-373752 3.911300e-02 1.408 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 4.370021e-02 1.360 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 4.885635e-02 1.311 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 4.370021e-02 1.360 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.708762e-02 1.327 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 4.082907e-02 1.389 0 0
Signaling by LTK R-HSA-9842663 3.788462e-02 1.422 0 0
Late Phase of HIV Life Cycle R-HSA-162599 4.898494e-02 1.310 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.657378e-02 1.332 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 4.989477e-02 1.302 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 4.828204e-02 1.316 0 0
Signaling by MET R-HSA-6806834 4.885635e-02 1.311 0 0
Gap junction assembly R-HSA-190861 4.828204e-02 1.316 0 0
TCR signaling R-HSA-202403 4.412958e-02 1.355 0 0
Hedgehog ligand biogenesis R-HSA-5358346 4.124220e-02 1.385 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 4.372212e-02 1.359 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 4.611495e-02 1.336 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.841185e-02 1.416 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 3.841185e-02 1.416 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 4.360115e-02 1.361 0 0
Base Excision Repair R-HSA-73884 3.857694e-02 1.414 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 4.454652e-02 1.351 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 5.025085e-02 1.299 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 4.869095e-02 1.313 0 0
XBP1(S) activates chaperone genes R-HSA-381038 4.886633e-02 1.311 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 5.165553e-02 1.287 0 0
Gene expression (Transcription) R-HSA-74160 5.295053e-02 1.276 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 5.402885e-02 1.267 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 5.402885e-02 1.267 0 0
Regulation of Apoptosis R-HSA-169911 5.448375e-02 1.264 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 5.448375e-02 1.264 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 5.563253e-02 1.255 0 0
Interleukin-1 family signaling R-HSA-446652 5.677103e-02 1.246 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.707285e-02 1.244 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 5.707285e-02 1.244 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.707285e-02 1.244 0 0
Centrosome maturation R-HSA-380287 5.735608e-02 1.241 0 0
Signaling by RAF1 mutants R-HSA-9656223 5.762132e-02 1.239 0 0
MAP2K and MAPK activation R-HSA-5674135 5.762132e-02 1.239 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 5.762132e-02 1.239 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 5.767102e-02 1.239 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 5.875107e-02 1.231 0 0
Neurodegenerative Diseases R-HSA-8863678 5.875107e-02 1.231 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 5.875107e-02 1.231 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 5.919149e-02 1.228 0 0
Translesion Synthesis by POLH R-HSA-110320 5.919149e-02 1.228 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 5.919149e-02 1.228 0 0
STING mediated induction of host immune responses R-HSA-1834941 5.919149e-02 1.228 0 0
The NLRP3 inflammasome R-HSA-844456 5.919149e-02 1.228 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 6.109603e-02 1.214 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 6.132318e-02 1.212 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 6.156921e-02 1.211 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 6.185760e-02 1.209 0 0
tRNA processing in the nucleus R-HSA-6784531 6.185760e-02 1.209 0 0
UCH proteinases R-HSA-5689603 6.211342e-02 1.207 0 0
PI3K/AKT activation R-HSA-198203 6.305563e-02 1.200 0 0
Josephin domain DUBs R-HSA-5689877 6.305563e-02 1.200 0 0
Pexophagy R-HSA-9664873 6.305563e-02 1.200 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 6.305563e-02 1.200 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 6.330504e-02 1.199 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 6.402039e-02 1.194 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 6.457476e-02 1.190 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 6.457476e-02 1.190 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 6.457476e-02 1.190 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 6.457476e-02 1.190 0 0
Maturation of protein E R-HSA-9683683 6.457476e-02 1.190 0 0
Maturation of protein E R-HSA-9694493 6.457476e-02 1.190 0 0
ER to Golgi Anterograde Transport R-HSA-199977 6.504265e-02 1.187 0 0
Degradation of CDH1 R-HSA-9766229 6.584296e-02 1.181 0 0
Cellular response to chemical stress R-HSA-9711123 6.640152e-02 1.178 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 6.690356e-02 1.175 0 0
TNF signaling R-HSA-75893 6.690356e-02 1.175 0 0
Sema4D in semaphorin signaling R-HSA-400685 6.733785e-02 1.172 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 6.742845e-02 1.171 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 6.838194e-02 1.165 0 0
Protein methylation R-HSA-8876725 6.841703e-02 1.165 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 6.841703e-02 1.165 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 7.085898e-02 1.150 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 7.085898e-02 1.150 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 7.159689e-02 1.145 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 7.267998e-02 1.139 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 7.298146e-02 1.137 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 7.323132e-02 1.135 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 7.423353e-02 1.129 0 0
rRNA processing R-HSA-72312 7.483573e-02 1.126 0 0
IRE1alpha activates chaperones R-HSA-381070 7.561338e-02 1.121 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.075933e-01 0.968 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.075933e-01 0.968 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.075933e-01 0.968 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.075933e-01 0.968 0 0
Regulation of TP53 Expression R-HSA-6804754 7.695074e-02 1.114 0 0
Diseases of cellular response to stress R-HSA-9675132 7.695074e-02 1.114 0 0
Diseases of Cellular Senescence R-HSA-9630747 7.695074e-02 1.114 0 0
Regulation of cortical dendrite branching R-HSA-8985801 7.695074e-02 1.114 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 7.695074e-02 1.114 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 7.695074e-02 1.114 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.118291e-01 0.951 0 0
Axonal growth stimulation R-HSA-209563 1.118291e-01 0.951 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 8.480516e-02 1.072 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 8.480516e-02 1.072 0 0
Ca2+ activated K+ channels R-HSA-1296052 1.073597e-01 0.969 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.073597e-01 0.969 0 0
IRAK1 recruits IKK complex R-HSA-937039 1.120554e-01 0.951 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 1.120554e-01 0.951 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 9.454064e-02 1.024 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 1.092540e-01 0.962 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 9.132763e-02 1.039 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 8.665351e-02 1.062 0 0
Interaction between L1 and Ankyrins R-HSA-445095 8.665351e-02 1.062 0 0
G-protein beta:gamma signalling R-HSA-397795 8.142905e-02 1.089 0 0
Late endosomal microautophagy R-HSA-9615710 1.087909e-01 0.963 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 8.431139e-02 1.074 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.007102e-01 0.997 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 9.404641e-02 1.027 0 0
Signaling downstream of RAS mutants R-HSA-9649948 9.404641e-02 1.027 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 9.404641e-02 1.027 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 9.416488e-02 1.026 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.834493e-02 1.007 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 8.239068e-02 1.084 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.097636e-01 0.960 0 0
Chaperonin-mediated protein folding R-HSA-390466 8.816246e-02 1.055 0 0
Integrin signaling R-HSA-354192 8.142905e-02 1.089 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 8.480516e-02 1.072 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 8.665351e-02 1.062 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 8.587046e-02 1.066 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 8.665351e-02 1.062 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 8.587046e-02 1.066 0 0
Signaling by RAS mutants R-HSA-6802949 9.404641e-02 1.027 0 0
Degradation of CRY and PER proteins R-HSA-9932298 1.120257e-01 0.951 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.120554e-01 0.951 0 0
Developmental Cell Lineages R-HSA-9734767 1.004636e-01 0.998 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 7.752056e-02 1.111 0 0
Activation of HOX genes during differentiation R-HSA-5619507 7.752056e-02 1.111 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.921304e-02 1.101 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.118291e-01 0.951 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.454064e-02 1.024 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 1.092540e-01 0.962 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 1.112305e-01 0.954 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 1.112305e-01 0.954 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 1.022824e-01 0.990 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 1.022824e-01 0.990 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.737458e-02 1.012 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 8.665351e-02 1.062 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.142905e-02 1.089 0 0
CHL1 interactions R-HSA-447041 1.073597e-01 0.969 0 0
RNA Polymerase II Transcription R-HSA-73857 9.647240e-02 1.016 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 8.377559e-02 1.077 0 0
Translation R-HSA-72766 9.672260e-02 1.014 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.022824e-01 0.990 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 1.106113e-01 0.956 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.587046e-02 1.066 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.587046e-02 1.066 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.137828e-01 0.944 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 1.087909e-01 0.963 0 0
Mitophagy R-HSA-5205647 1.007102e-01 0.997 0 0
Signaling by NOTCH R-HSA-157118 1.031714e-01 0.986 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.304266e-02 1.031 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.663911e-02 1.116 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 1.037795e-01 0.984 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 8.587046e-02 1.066 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.073597e-01 0.969 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.073597e-01 0.969 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.077386e-02 1.042 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 1.007102e-01 0.997 0 0
Signaling by Hedgehog R-HSA-5358351 8.524785e-02 1.069 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.095956e-01 0.960 0 0
Negative regulation of FLT3 R-HSA-9706369 8.091523e-02 1.092 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 1.120554e-01 0.951 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 1.120554e-01 0.951 0 0
Regulation of gene expression in beta cells R-HSA-210745 1.087909e-01 0.963 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.649055e-02 1.063 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 8.142905e-02 1.089 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.170666e-01 0.932 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.195563e-01 0.922 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.195563e-01 0.922 0 0
PCP/CE pathway R-HSA-4086400 1.200805e-01 0.921 0 0
Activation of the pre-replicative complex R-HSA-68962 1.208864e-01 0.918 0 0
DAP12 signaling R-HSA-2424491 1.208864e-01 0.918 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.208864e-01 0.918 0 0
Activation of BH3-only proteins R-HSA-114452 1.208864e-01 0.918 0 0
Interleukin-37 signaling R-HSA-9008059 1.208864e-01 0.918 0 0
DNA Damage Bypass R-HSA-73893 1.212331e-01 0.916 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 1.223239e-01 0.912 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.231480e-01 0.910 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.231480e-01 0.910 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.250053e-01 0.903 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.250053e-01 0.903 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.250053e-01 0.903 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.270628e-01 0.896 0 0
G1/S Transition R-HSA-69206 1.273138e-01 0.895 0 0
Protein folding R-HSA-391251 1.280939e-01 0.892 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.287980e-01 0.890 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.312624e-01 0.882 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.312624e-01 0.882 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.312624e-01 0.882 0 0
Interleukin-6 signaling R-HSA-1059683 1.312624e-01 0.882 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.312624e-01 0.882 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.312624e-01 0.882 0 0
Type I hemidesmosome assembly R-HSA-446107 1.319514e-01 0.880 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 1.319514e-01 0.880 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.319514e-01 0.880 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.319514e-01 0.880 0 0
Adrenoceptors R-HSA-390696 1.319514e-01 0.880 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 1.319514e-01 0.880 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 1.319514e-01 0.880 0 0
Modulation by Mtb of host immune system R-HSA-9637628 1.319514e-01 0.880 0 0
DNA Repair R-HSA-73894 1.334602e-01 0.875 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.339761e-01 0.873 0 0
Degradation of AXIN R-HSA-4641257 1.339761e-01 0.873 0 0
Cellular response to hypoxia R-HSA-1234174 1.350633e-01 0.869 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 1.415172e-01 0.849 0 0
Germ layer formation at gastrulation R-HSA-9754189 1.417346e-01 0.849 0 0
G1 Phase R-HSA-69236 1.441889e-01 0.841 0 0
Cyclin D associated events in G1 R-HSA-69231 1.441889e-01 0.841 0 0
HDMs demethylate histones R-HSA-3214842 1.460160e-01 0.836 0 0
Long-term potentiation R-HSA-9620244 1.460160e-01 0.836 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.461701e-01 0.835 0 0
Signaling by NOTCH4 R-HSA-9013694 1.493168e-01 0.826 0 0
Regulation of gap junction activity R-HSA-191650 1.498898e-01 0.824 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.498898e-01 0.824 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.498898e-01 0.824 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 1.498898e-01 0.824 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.498898e-01 0.824 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.498898e-01 0.824 0 0
MTF1 activates gene expression R-HSA-5660489 1.498898e-01 0.824 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 1.506369e-01 0.822 0 0
HCMV Late Events R-HSA-9610379 1.511368e-01 0.821 0 0
Regulation of KIT signaling R-HSA-1433559 1.517147e-01 0.819 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.517147e-01 0.819 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.522807e-01 0.817 0 0
Neurexins and neuroligins R-HSA-6794361 1.522807e-01 0.817 0 0
DAG and IP3 signaling R-HSA-1489509 1.558474e-01 0.807 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 1.558474e-01 0.807 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 1.582802e-01 0.801 0 0
ALK mutants bind TKIs R-HSA-9700645 1.582802e-01 0.801 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.582802e-01 0.801 0 0
p75NTR regulates axonogenesis R-HSA-193697 1.582802e-01 0.801 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.582802e-01 0.801 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.582802e-01 0.801 0 0
Muscle contraction R-HSA-397014 1.587607e-01 0.799 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 1.588860e-01 0.799 0 0
Signaling by ALK R-HSA-201556 1.588860e-01 0.799 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 1.593745e-01 0.798 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 1.593745e-01 0.798 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.593745e-01 0.798 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.610219e-01 0.793 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.610219e-01 0.793 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 1.615989e-01 0.792 0 0
Metalloprotease DUBs R-HSA-5689901 1.615989e-01 0.792 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.640342e-01 0.785 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.640342e-01 0.785 0 0
Cilium Assembly R-HSA-5617833 1.647307e-01 0.783 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.655876e-01 0.781 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.679489e-01 0.775 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.679489e-01 0.775 0 0
Signaling by NOTCH1 R-HSA-1980143 1.682744e-01 0.774 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.036158e-01 0.691 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.036158e-01 0.691 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.036158e-01 0.691 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.036158e-01 0.691 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.036158e-01 0.691 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 2.036158e-01 0.691 0 0
Defective GALM causes GALAC4 R-HSA-9931929 2.036158e-01 0.691 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.036158e-01 0.691 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.036158e-01 0.691 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 2.036158e-01 0.691 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.036158e-01 0.691 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 2.893114e-01 0.539 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.893114e-01 0.539 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 2.893114e-01 0.539 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.893114e-01 0.539 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 2.893114e-01 0.539 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 2.893114e-01 0.539 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 2.893114e-01 0.539 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 2.893114e-01 0.539 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 2.893114e-01 0.539 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 2.893114e-01 0.539 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 2.893114e-01 0.539 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 2.893114e-01 0.539 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.893114e-01 0.539 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 2.893114e-01 0.539 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.893114e-01 0.539 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 2.893114e-01 0.539 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 2.893114e-01 0.539 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 2.893114e-01 0.539 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 2.893114e-01 0.539 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.900451e-01 0.721 0 0
IRS activation R-HSA-74713 1.900451e-01 0.721 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.900451e-01 0.721 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 1.900451e-01 0.721 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 2.314042e-01 0.636 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.314042e-01 0.636 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 2.314042e-01 0.636 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.314042e-01 0.636 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.314042e-01 0.636 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 2.314042e-01 0.636 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.860441e-01 0.730 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.860441e-01 0.730 0 0
Signaling by LTK in cancer R-HSA-9842640 2.732438e-01 0.563 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.732438e-01 0.563 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 2.732438e-01 0.563 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 2.732438e-01 0.563 0 0
Processive synthesis on the lagging strand R-HSA-69183 1.732802e-01 0.761 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.732802e-01 0.761 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.732802e-01 0.761 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 1.732802e-01 0.761 0 0
Translesion synthesis by POLI R-HSA-5656121 1.958208e-01 0.708 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.958208e-01 0.708 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 2.447075e-01 0.611 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.447075e-01 0.611 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.447075e-01 0.611 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 3.149821e-01 0.502 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 3.149821e-01 0.502 0 0
TRIF-mediated programmed cell death R-HSA-2562578 3.149821e-01 0.502 0 0
Recycling of eIF2:GDP R-HSA-72731 3.149821e-01 0.502 0 0
SOS-mediated signalling R-HSA-112412 3.149821e-01 0.502 0 0
Lagging Strand Synthesis R-HSA-69186 1.778507e-01 0.750 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.191950e-01 0.659 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 2.191950e-01 0.659 0 0
Translesion synthesis by POLK R-HSA-5655862 2.191950e-01 0.659 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.191950e-01 0.659 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 2.750588e-01 0.561 0 0
Leading Strand Synthesis R-HSA-69109 2.750588e-01 0.561 0 0
Polymerase switching R-HSA-69091 2.750588e-01 0.561 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.750588e-01 0.561 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.750588e-01 0.561 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.750588e-01 0.561 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.750588e-01 0.561 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.750588e-01 0.561 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.750588e-01 0.561 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 2.432610e-01 0.614 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.432610e-01 0.614 0 0
Notch-HLH transcription pathway R-HSA-350054 2.169916e-01 0.664 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 3.057555e-01 0.515 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 3.057555e-01 0.515 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 3.057555e-01 0.515 0 0
GAB1 signalosome R-HSA-180292 2.678786e-01 0.572 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.678786e-01 0.572 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 2.374882e-01 0.624 0 0
Termination of translesion DNA synthesis R-HSA-5656169 2.122080e-01 0.673 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 2.122080e-01 0.673 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 2.929114e-01 0.533 0 0
Removal of the Flap Intermediate R-HSA-69166 3.365736e-01 0.473 0 0
MET promotes cell motility R-HSA-8875878 2.557310e-01 0.592 0 0
Cristae formation R-HSA-8949613 3.236406e-01 0.490 0 0
RAF activation R-HSA-5673000 3.257609e-01 0.487 0 0
Dual Incision in GG-NER R-HSA-5696400 3.257609e-01 0.487 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 2.924337e-01 0.534 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 3.085716e-01 0.511 0 0
Generation of second messenger molecules R-HSA-202433 2.904264e-01 0.537 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.857908e-01 0.731 0 0
Formation of definitive endoderm R-HSA-9823730 3.182281e-01 0.497 0 0
Nucleotide Excision Repair R-HSA-5696398 2.646233e-01 0.577 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.388627e-01 0.622 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.823907e-01 0.739 0 0
GPER1 signaling R-HSA-9634597 1.934061e-01 0.714 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.904264e-01 0.537 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.823907e-01 0.739 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.823907e-01 0.739 0 0
FOXO-mediated transcription R-HSA-9614085 2.765431e-01 0.558 0 0
Circadian clock R-HSA-9909396 3.306950e-01 0.481 0 0
DNA strand elongation R-HSA-69190 2.674567e-01 0.573 0 0
Signal attenuation R-HSA-74749 1.860441e-01 0.730 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 3.365736e-01 0.473 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.633277e-01 0.580 0 0
Mismatch Repair R-HSA-5358508 2.678786e-01 0.572 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.603516e-01 0.584 0 0
Regulation of CDH11 function R-HSA-9762292 1.860441e-01 0.730 0 0
Translesion synthesis by REV1 R-HSA-110312 1.732802e-01 0.761 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.906952e-01 0.720 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.848994e-01 0.733 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.067201e-01 0.685 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.340661e-01 0.476 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.732802e-01 0.761 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 3.149821e-01 0.502 0 0
Formation of axial mesoderm R-HSA-9796292 3.057555e-01 0.515 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.514162e-01 0.600 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.514162e-01 0.600 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.514162e-01 0.600 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.514162e-01 0.600 0 0
IGF1R signaling cascade R-HSA-2428924 3.077112e-01 0.512 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 3.016484e-01 0.520 0 0
Pyrophosphate hydrolysis R-HSA-71737 1.900451e-01 0.721 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.314042e-01 0.636 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.191950e-01 0.659 0 0
Signaling by SCF-KIT R-HSA-1433557 2.294276e-01 0.639 0 0
Signaling by TGFB family members R-HSA-9006936 2.292864e-01 0.640 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.063028e-01 0.685 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 1.804751e-01 0.744 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 2.233934e-01 0.651 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 3.222506e-01 0.492 0 0
Calmodulin induced events R-HSA-111933 2.223724e-01 0.653 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.732802e-01 0.761 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.848994e-01 0.733 0 0
Nuclear RNA decay R-HSA-9930044 2.866314e-01 0.543 0 0
Vesicle-mediated transport R-HSA-5653656 2.233063e-01 0.651 0 0
CaM pathway R-HSA-111997 2.223724e-01 0.653 0 0
Intraflagellar transport R-HSA-5620924 3.088231e-01 0.510 0 0
Neurofascin interactions R-HSA-447043 2.732438e-01 0.563 0 0
Generic Transcription Pathway R-HSA-212436 2.766905e-01 0.558 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 1.970840e-01 0.705 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.191950e-01 0.659 0 0
Signal transduction by L1 R-HSA-445144 3.182281e-01 0.497 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 3.313335e-01 0.480 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 3.064304e-01 0.514 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.813134e-01 0.742 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.261039e-01 0.487 0 0
Rab regulation of trafficking R-HSA-9007101 3.269965e-01 0.485 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.514162e-01 0.600 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 2.990683e-01 0.524 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 3.130586e-01 0.504 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.036158e-01 0.691 0 0
Inhibition of PKR R-HSA-169131 2.036158e-01 0.691 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.893114e-01 0.539 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.893114e-01 0.539 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 2.893114e-01 0.539 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 2.314042e-01 0.636 0 0
Proton/oligopeptide cotransporters R-HSA-427975 2.314042e-01 0.636 0 0
NOD1/2 Signaling Pathway R-HSA-168638 1.906952e-01 0.720 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 2.933349e-01 0.533 0 0
Signaling by FGFR4 R-HSA-5654743 2.294276e-01 0.639 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 2.486214e-01 0.604 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 2.635746e-01 0.579 0 0
Signaling by FGFR1 R-HSA-5654736 1.991767e-01 0.701 0 0
Platelet sensitization by LDL R-HSA-432142 2.678786e-01 0.572 0 0
Signaling by FGFR3 R-HSA-5654741 2.603516e-01 0.584 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.778507e-01 0.750 0 0
Somitogenesis R-HSA-9824272 2.603516e-01 0.584 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 1.999280e-01 0.699 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 1.999280e-01 0.699 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.321509e-01 0.634 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.149821e-01 0.502 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.732802e-01 0.761 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 1.958208e-01 0.708 0 0
Regulation of pyruvate metabolism R-HSA-9861718 2.762649e-01 0.559 0 0
Inflammasomes R-HSA-622312 1.947473e-01 0.711 0 0
Gluconeogenesis R-HSA-70263 3.088231e-01 0.510 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.893114e-01 0.539 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 1.900451e-01 0.721 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.732438e-01 0.563 0 0
SLC-mediated transport of oligopeptides R-HSA-9959399 3.149821e-01 0.502 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.778507e-01 0.750 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.694745e-01 0.771 0 0
Regulated Necrosis R-HSA-5218859 2.531667e-01 0.597 0 0
Protein hydroxylation R-HSA-9629569 3.182281e-01 0.497 0 0
Syndecan interactions R-HSA-3000170 2.374882e-01 0.624 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 1.900451e-01 0.721 0 0
VLDLR internalisation and degradation R-HSA-8866427 2.750588e-01 0.561 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 3.365736e-01 0.473 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 3.085716e-01 0.511 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.745881e-01 0.758 0 0
Response of Mtb to phagocytosis R-HSA-9637690 2.294276e-01 0.639 0 0
Glycogen synthesis R-HSA-3322077 3.182281e-01 0.497 0 0
RMTs methylate histone arginines R-HSA-3214858 2.447279e-01 0.611 0 0
Hedgehog 'on' state R-HSA-5632684 2.928343e-01 0.533 0 0
Specification of primordial germ cells R-HSA-9827857 2.432610e-01 0.614 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.314042e-01 0.636 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.314042e-01 0.636 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 3.149821e-01 0.502 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 1.970840e-01 0.705 0 0
Glycogen storage diseases R-HSA-3229121 2.432610e-01 0.614 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 3.074097e-01 0.512 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.835888e-01 0.736 0 0
MHC class II antigen presentation R-HSA-2132295 2.240998e-01 0.650 0 0
Downstream TCR signaling R-HSA-202424 3.408308e-01 0.467 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 3.410256e-01 0.467 0 0
Inositol phosphate metabolism R-HSA-1483249 3.417076e-01 0.466 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 3.433308e-01 0.464 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 3.437042e-01 0.464 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 3.437042e-01 0.464 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 3.437042e-01 0.464 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 3.437042e-01 0.464 0 0
Ca-dependent events R-HSA-111996 3.442003e-01 0.463 0 0
Platelet degranulation R-HSA-114608 3.556777e-01 0.449 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 3.561566e-01 0.448 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.561566e-01 0.448 0 0
Sodium/Proton exchangers R-HSA-425986 3.561566e-01 0.448 0 0
Interleukin-23 signaling R-HSA-9020933 3.561566e-01 0.448 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.561566e-01 0.448 0 0
Toll-like Receptor Cascades R-HSA-168898 3.600877e-01 0.444 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.618894e-01 0.441 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.618894e-01 0.441 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.618894e-01 0.441 0 0
Potential therapeutics for SARS R-HSA-9679191 3.631385e-01 0.440 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.657902e-01 0.437 0 0
Glycogen storage disease type IV (GBE1) R-HSA-3878781 3.657902e-01 0.437 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 3.657902e-01 0.437 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 3.657902e-01 0.437 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.657902e-01 0.437 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 3.657902e-01 0.437 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.657902e-01 0.437 0 0
C6 deamination of adenosine R-HSA-75102 3.657902e-01 0.437 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.657902e-01 0.437 0 0
Interleukin-33 signaling R-HSA-9014843 3.657902e-01 0.437 0 0
DSCAM interactions R-HSA-376172 3.657902e-01 0.437 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.657902e-01 0.437 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.666139e-01 0.436 0 0
Erythropoietin activates RAS R-HSA-9027284 3.673117e-01 0.435 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.673117e-01 0.435 0 0
G beta:gamma signalling through BTK R-HSA-8964315 3.673117e-01 0.435 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 3.673117e-01 0.435 0 0
Signaling by Erythropoietin R-HSA-9006335 3.680416e-01 0.434 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.680416e-01 0.434 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.692222e-01 0.433 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 3.692222e-01 0.433 0 0
Assembly Of The HIV Virion R-HSA-175474 3.692222e-01 0.433 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.758936e-01 0.425 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.761024e-01 0.425 0 0
Neutrophil degranulation R-HSA-6798695 3.793163e-01 0.421 0 0
Proteasome assembly R-HSA-9907900 3.806913e-01 0.419 0 0
DAP12 interactions R-HSA-2172127 3.806913e-01 0.419 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.815722e-01 0.418 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 3.848636e-01 0.415 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 3.848636e-01 0.415 0 0
PLC beta mediated events R-HSA-112043 3.870732e-01 0.412 0 0
Formation of paraxial mesoderm R-HSA-9793380 3.870732e-01 0.412 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 3.870732e-01 0.412 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 3.878000e-01 0.411 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 3.882467e-01 0.411 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.902974e-01 0.409 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 3.928688e-01 0.406 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.933962e-01 0.405 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.946731e-01 0.404 0 0
Lipophagy R-HSA-9613354 3.964057e-01 0.402 0 0
WNT mediated activation of DVL R-HSA-201688 3.964057e-01 0.402 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 3.964057e-01 0.402 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.964057e-01 0.402 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.964057e-01 0.402 0 0
MAPK1 (ERK2) activation R-HSA-112411 3.964057e-01 0.402 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.964057e-01 0.402 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.964057e-01 0.402 0 0
Interleukin-1 processing R-HSA-448706 3.964057e-01 0.402 0 0
Phosphorylation of the APC/C R-HSA-176412 3.977908e-01 0.400 0 0
Phase 4 - resting membrane potential R-HSA-5576886 3.977908e-01 0.400 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.977908e-01 0.400 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.977908e-01 0.400 0 0
Regulation of BACH1 activity R-HSA-9708530 3.977908e-01 0.400 0 0
Sensory processing of sound R-HSA-9659379 4.048166e-01 0.393 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 4.054695e-01 0.392 0 0
Pyruvate metabolism R-HSA-70268 4.120711e-01 0.385 0 0
Budding and maturation of HIV virion R-HSA-162588 4.124943e-01 0.385 0 0
Downstream signal transduction R-HSA-186763 4.124943e-01 0.385 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 4.124943e-01 0.385 0 0
Signaling by TGFBR3 R-HSA-9839373 4.173030e-01 0.380 0 0
Interleukin receptor SHC signaling R-HSA-912526 4.199563e-01 0.377 0 0
Growth hormone receptor signaling R-HSA-982772 4.199563e-01 0.377 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 4.254627e-01 0.371 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 4.278541e-01 0.369 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 4.278541e-01 0.369 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 4.278541e-01 0.369 0 0
Disorders of Developmental Biology R-HSA-9675151 4.278541e-01 0.369 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 4.278541e-01 0.369 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 4.340429e-01 0.362 0 0
PLC-gamma1 signalling R-HSA-167021 4.340429e-01 0.362 0 0
Classical Kir channels R-HSA-1296053 4.340429e-01 0.362 0 0
MET activates PTPN11 R-HSA-8865999 4.340429e-01 0.362 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.340429e-01 0.362 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.340429e-01 0.362 0 0
FasL/ CD95L signaling R-HSA-75157 4.340429e-01 0.362 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 4.340429e-01 0.362 0 0
G0 and Early G1 R-HSA-1538133 4.345660e-01 0.362 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 4.345660e-01 0.362 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.354518e-01 0.361 0 0
Formation of apoptosome R-HSA-111458 4.354518e-01 0.361 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.354518e-01 0.361 0 0
Regulation of the apoptosome activity R-HSA-9627069 4.354518e-01 0.361 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 4.354518e-01 0.361 0 0
Interleukin-27 signaling R-HSA-9020956 4.354518e-01 0.361 0 0
2-LTR circle formation R-HSA-164843 4.354518e-01 0.361 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 4.354518e-01 0.361 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.354518e-01 0.361 0 0
MAPK3 (ERK1) activation R-HSA-110056 4.354518e-01 0.361 0 0
Signaling by Leptin R-HSA-2586552 4.354518e-01 0.361 0 0
ER-Phagosome pathway R-HSA-1236974 4.393237e-01 0.357 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 4.439463e-01 0.353 0 0
Deadenylation of mRNA R-HSA-429947 4.449800e-01 0.352 0 0
Interleukin-6 family signaling R-HSA-6783589 4.449800e-01 0.352 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 4.449800e-01 0.352 0 0
Diseases of Immune System R-HSA-5260271 4.452995e-01 0.351 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 4.452995e-01 0.351 0 0
Glycogen metabolism R-HSA-8982491 4.452995e-01 0.351 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.462408e-01 0.350 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.462408e-01 0.350 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.462408e-01 0.350 0 0
RSV-host interactions R-HSA-9833110 4.494792e-01 0.347 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 4.538836e-01 0.343 0 0
Adaptive Immune System R-HSA-1280218 4.556326e-01 0.341 0 0
FGFR1 mutant receptor activation R-HSA-1839124 4.564506e-01 0.341 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 4.564506e-01 0.341 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 4.564506e-01 0.341 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 4.564506e-01 0.341 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 4.573659e-01 0.340 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 4.573659e-01 0.340 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 4.573659e-01 0.340 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 4.595964e-01 0.338 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 4.618447e-01 0.336 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 4.649902e-01 0.333 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 4.696615e-01 0.328 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.696615e-01 0.328 0 0
Tight junction interactions R-HSA-420029 4.696615e-01 0.328 0 0
TGFBR3 expression R-HSA-9839394 4.696615e-01 0.328 0 0
Interleukin-7 signaling R-HSA-1266695 4.696615e-01 0.328 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 4.730880e-01 0.325 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.730880e-01 0.325 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.730880e-01 0.325 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.730880e-01 0.325 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 4.730880e-01 0.325 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.730880e-01 0.325 0 0
Synthesis of PI R-HSA-1483226 4.730880e-01 0.325 0 0
Bicarbonate transporters R-HSA-425381 4.730880e-01 0.325 0 0
Signaling by APC mutants R-HSA-4839744 4.730880e-01 0.325 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.730880e-01 0.325 0 0
Suppression of apoptosis R-HSA-9635465 4.730880e-01 0.325 0 0
Interleukin-2 signaling R-HSA-9020558 4.730880e-01 0.325 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.730880e-01 0.325 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 4.730880e-01 0.325 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 4.780911e-01 0.320 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 4.780911e-01 0.320 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 4.812488e-01 0.318 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 4.812488e-01 0.318 0 0
G-protein mediated events R-HSA-112040 4.821805e-01 0.317 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.821805e-01 0.317 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 4.844923e-01 0.315 0 0
PKA activation R-HSA-163615 4.862111e-01 0.313 0 0
PKA activation in glucagon signalling R-HSA-164378 4.862111e-01 0.313 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 4.862111e-01 0.313 0 0
Apoptotic factor-mediated response R-HSA-111471 4.862111e-01 0.313 0 0
Presynaptic function of Kainate receptors R-HSA-500657 4.862111e-01 0.313 0 0
Tie2 Signaling R-HSA-210993 4.862111e-01 0.313 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.939269e-01 0.306 0 0
Myogenesis R-HSA-525793 4.939269e-01 0.306 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 4.939269e-01 0.306 0 0
Suppression of phagosomal maturation R-HSA-9637687 4.939269e-01 0.306 0 0
Extension of Telomeres R-HSA-180786 4.940105e-01 0.306 0 0
Regulation of beta-cell development R-HSA-186712 4.940105e-01 0.306 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.949539e-01 0.305 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 4.949539e-01 0.305 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.949539e-01 0.305 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.949539e-01 0.305 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.949539e-01 0.305 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.949539e-01 0.305 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.949539e-01 0.305 0 0
Defective MAT1A causes MATD R-HSA-5579024 4.949539e-01 0.305 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.949539e-01 0.305 0 0
Sensory perception of sour taste R-HSA-9729555 4.949539e-01 0.305 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.949539e-01 0.305 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 4.949539e-01 0.305 0 0
ABC-family proteins mediated transport R-HSA-382556 4.965223e-01 0.304 0 0
Signaling by NOTCH2 R-HSA-1980145 4.994353e-01 0.302 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 5.037666e-01 0.298 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 5.037666e-01 0.298 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.091654e-01 0.293 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 5.091654e-01 0.293 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 5.091654e-01 0.293 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 5.091654e-01 0.293 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 5.091654e-01 0.293 0 0
Integration of provirus R-HSA-162592 5.091654e-01 0.293 0 0
Signaling by AMER1 mutants R-HSA-4839748 5.091654e-01 0.293 0 0
Signaling by AXIN mutants R-HSA-4839735 5.091654e-01 0.293 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.091654e-01 0.293 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 5.091654e-01 0.293 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 5.091654e-01 0.293 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 5.142931e-01 0.289 0 0
E2F mediated regulation of DNA replication R-HSA-113510 5.142931e-01 0.289 0 0
Maturation of nucleoprotein R-HSA-9694631 5.142931e-01 0.289 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 5.177108e-01 0.286 0 0
Insulin processing R-HSA-264876 5.177108e-01 0.286 0 0
TBC/RABGAPs R-HSA-8854214 5.227766e-01 0.282 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 5.262372e-01 0.279 0 0
MAP kinase activation R-HSA-450294 5.267766e-01 0.278 0 0
Infectious disease R-HSA-5663205 5.376227e-01 0.270 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 5.409567e-01 0.267 0 0
GPVI-mediated activation cascade R-HSA-114604 5.410499e-01 0.267 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 5.415330e-01 0.266 0 0
Signaling by NODAL R-HSA-1181150 5.415330e-01 0.266 0 0
Heme signaling R-HSA-9707616 5.428704e-01 0.265 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.428704e-01 0.265 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.435837e-01 0.265 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 5.435837e-01 0.265 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 5.435837e-01 0.265 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 5.435837e-01 0.265 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 5.435837e-01 0.265 0 0
Regulation of IFNG signaling R-HSA-877312 5.435837e-01 0.265 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.435837e-01 0.265 0 0
Disorders of Nervous System Development R-HSA-9697154 5.435837e-01 0.265 0 0
Pervasive developmental disorders R-HSA-9005895 5.435837e-01 0.265 0 0
Interleukin-35 Signalling R-HSA-8984722 5.435837e-01 0.265 0 0
Interleukin-15 signaling R-HSA-8983432 5.435837e-01 0.265 0 0
OAS antiviral response R-HSA-8983711 5.435837e-01 0.265 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 5.436871e-01 0.265 0 0
Signaling by FGFR2 R-HSA-5654738 5.445454e-01 0.264 0 0
Opioid Signalling R-HSA-111885 5.472271e-01 0.262 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 5.493126e-01 0.260 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 5.493126e-01 0.260 0 0
G2 Phase R-HSA-68911 5.493126e-01 0.260 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 5.493126e-01 0.260 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.493126e-01 0.260 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.493126e-01 0.260 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.493126e-01 0.260 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 5.493126e-01 0.260 0 0
Reelin signalling pathway R-HSA-8866376 5.493126e-01 0.260 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.493126e-01 0.260 0 0
Interleukin-36 pathway R-HSA-9014826 5.493126e-01 0.260 0 0
NrCAM interactions R-HSA-447038 5.493126e-01 0.260 0 0
Co-inhibition by BTLA R-HSA-9927353 5.493126e-01 0.260 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.493126e-01 0.260 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.493126e-01 0.260 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.493126e-01 0.260 0 0
Neuronal System R-HSA-112316 5.546312e-01 0.256 0 0
Platelet activation, signaling and aggregation R-HSA-76002 5.560901e-01 0.255 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 5.598743e-01 0.252 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 5.636157e-01 0.249 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.636157e-01 0.249 0 0
DARPP-32 events R-HSA-180024 5.636157e-01 0.249 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 5.678678e-01 0.246 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 5.678678e-01 0.246 0 0
Ca2+ pathway R-HSA-4086398 5.733812e-01 0.242 0 0
Signaling by NOTCH3 R-HSA-9012852 5.758178e-01 0.240 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 5.762822e-01 0.239 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 5.762822e-01 0.239 0 0
Frs2-mediated activation R-HSA-170968 5.762822e-01 0.239 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 5.762822e-01 0.239 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 5.762822e-01 0.239 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 5.779046e-01 0.238 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 5.779046e-01 0.238 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 5.809728e-01 0.236 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 5.809728e-01 0.236 0 0
Signaling by FGFR R-HSA-190236 5.846497e-01 0.233 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 5.856469e-01 0.232 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 5.922140e-01 0.228 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 5.932492e-01 0.227 0 0
Signaling by PDGFR in disease R-HSA-9671555 5.932492e-01 0.227 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 5.945225e-01 0.226 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.978234e-01 0.223 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.978234e-01 0.223 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 5.978234e-01 0.223 0 0
Signaling by MAPK mutants R-HSA-9652817 5.978234e-01 0.223 0 0
Signaling by RNF43 mutants R-HSA-5340588 5.978234e-01 0.223 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.978234e-01 0.223 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 5.978234e-01 0.223 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.978234e-01 0.223 0 0
TRAIL signaling R-HSA-75158 5.978234e-01 0.223 0 0
Pentose phosphate pathway disease R-HSA-6791465 5.978234e-01 0.223 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.978234e-01 0.223 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.978234e-01 0.223 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 5.978234e-01 0.223 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 5.978234e-01 0.223 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 5.978234e-01 0.223 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 5.978234e-01 0.223 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.978234e-01 0.223 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 5.978234e-01 0.223 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 5.978234e-01 0.223 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 5.978234e-01 0.223 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 6.002196e-01 0.222 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 6.021942e-01 0.220 0 0
cGMP effects R-HSA-418457 6.072323e-01 0.217 0 0
Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-HSA-77348 6.072323e-01 0.217 0 0
Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-HSA-77350 6.072323e-01 0.217 0 0
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA R-HSA-77310 6.072323e-01 0.217 0 0
Signaling by FGFR4 in disease R-HSA-5655291 6.072323e-01 0.217 0 0
Signal regulatory protein family interactions R-HSA-391160 6.072323e-01 0.217 0 0
Antigen processing-Cross presentation R-HSA-1236975 6.078896e-01 0.216 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.171740e-01 0.210 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 6.176419e-01 0.209 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 6.176419e-01 0.209 0 0
Interleukin-2 family signaling R-HSA-451927 6.189560e-01 0.208 0 0
Dual incision in TC-NER R-HSA-6782135 6.240116e-01 0.205 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 6.244986e-01 0.204 0 0
Signaling by WNT in cancer R-HSA-4791275 6.276979e-01 0.202 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 6.276993e-01 0.202 0 0
Translation of Structural Proteins R-HSA-9694635 6.300187e-01 0.201 0 0
PI Metabolism R-HSA-1483255 6.334421e-01 0.198 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.364315e-01 0.196 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 6.364315e-01 0.196 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 6.364315e-01 0.196 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 6.364315e-01 0.196 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.411152e-01 0.193 0 0
STAT5 Activation R-HSA-9645135 6.411152e-01 0.193 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.411152e-01 0.193 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.411152e-01 0.193 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 6.411152e-01 0.193 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 6.411152e-01 0.193 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 6.411152e-01 0.193 0 0
CREB phosphorylation R-HSA-199920 6.411152e-01 0.193 0 0
VLDL assembly R-HSA-8866423 6.411152e-01 0.193 0 0
HDL clearance R-HSA-8964011 6.411152e-01 0.193 0 0
Nef and signal transduction R-HSA-164944 6.411152e-01 0.193 0 0
CREB3 factors activate genes R-HSA-8874211 6.411152e-01 0.193 0 0
ABC transporter disorders R-HSA-5619084 6.435318e-01 0.191 0 0
PI3K Cascade R-HSA-109704 6.460386e-01 0.190 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 6.476701e-01 0.189 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 6.476701e-01 0.189 0 0
Signaling by Retinoic Acid R-HSA-5362517 6.543840e-01 0.184 0 0
Intra-Golgi traffic R-HSA-6811438 6.548201e-01 0.184 0 0
Interleukin-17 signaling R-HSA-448424 6.622575e-01 0.179 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 6.633768e-01 0.178 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 6.633768e-01 0.178 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.638982e-01 0.178 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 6.638982e-01 0.178 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 6.638982e-01 0.178 0 0
Killing mechanisms R-HSA-9664420 6.638982e-01 0.178 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.638982e-01 0.178 0 0
Prolonged ERK activation events R-HSA-169893 6.638982e-01 0.178 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.638982e-01 0.178 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 6.638982e-01 0.178 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.638982e-01 0.178 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 6.669183e-01 0.176 0 0
Miscellaneous transport and binding events R-HSA-5223345 6.669183e-01 0.176 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 6.671178e-01 0.176 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 6.690059e-01 0.175 0 0
Potassium Channels R-HSA-1296071 6.720707e-01 0.173 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 6.797492e-01 0.168 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 6.797492e-01 0.168 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.797492e-01 0.168 0 0
Netrin mediated repulsion signals R-HSA-418886 6.797492e-01 0.168 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.797492e-01 0.168 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 6.797492e-01 0.168 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.797492e-01 0.168 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.797492e-01 0.168 0 0
Disinhibition of SNARE formation R-HSA-114516 6.797492e-01 0.168 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.797492e-01 0.168 0 0
DAG1 core M1 glycosylations R-HSA-8932506 6.797492e-01 0.168 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 6.797492e-01 0.168 0 0
PTK6 Expression R-HSA-8849473 6.797492e-01 0.168 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.797492e-01 0.168 0 0
LDL remodeling R-HSA-8964041 6.797492e-01 0.168 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.797492e-01 0.168 0 0
Maturation of replicase proteins R-HSA-9694301 6.797492e-01 0.168 0 0
Mitochondrial protein import R-HSA-1268020 6.832395e-01 0.165 0 0
Signaling by PDGF R-HSA-186797 6.832395e-01 0.165 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 6.847015e-01 0.164 0 0
G protein gated Potassium channels R-HSA-1296059 6.847015e-01 0.164 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 6.847015e-01 0.164 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 6.847015e-01 0.164 0 0
Laminin interactions R-HSA-3000157 6.847015e-01 0.164 0 0
Formation of the nephric duct R-HSA-9830364 6.847015e-01 0.164 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 6.854332e-01 0.164 0 0
eNOS activation R-HSA-203615 6.854332e-01 0.164 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 6.854332e-01 0.164 0 0
RA biosynthesis pathway R-HSA-5365859 6.854332e-01 0.164 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 6.854332e-01 0.164 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 6.896669e-01 0.161 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 6.896669e-01 0.161 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.896669e-01 0.161 0 0
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-HSA-77346 6.896669e-01 0.161 0 0
Response to metal ions R-HSA-5660526 6.896669e-01 0.161 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 7.003148e-01 0.155 0 0
Signaling by NTRKs R-HSA-166520 7.010252e-01 0.154 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 7.032098e-01 0.153 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.032098e-01 0.153 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 7.032098e-01 0.153 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 7.049998e-01 0.152 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 7.049998e-01 0.152 0 0
Interferon alpha/beta signaling R-HSA-909733 7.063386e-01 0.151 0 0
Gastrulation R-HSA-9758941 7.099149e-01 0.149 0 0
Insulin receptor signalling cascade R-HSA-74751 7.105152e-01 0.148 0 0
Ion transport by P-type ATPases R-HSA-936837 7.105152e-01 0.148 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 7.137848e-01 0.146 0 0
Regulation by c-FLIP R-HSA-3371378 7.142262e-01 0.146 0 0
RSK activation R-HSA-444257 7.142262e-01 0.146 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 7.142262e-01 0.146 0 0
DAG1 core M2 glycosylations R-HSA-8932504 7.142262e-01 0.146 0 0
Dimerization of procaspase-8 R-HSA-69416 7.142262e-01 0.146 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.142262e-01 0.146 0 0
MET receptor recycling R-HSA-8875656 7.142262e-01 0.146 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.142262e-01 0.146 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.142262e-01 0.146 0 0
Co-stimulation by ICOS R-HSA-9927354 7.142262e-01 0.146 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.142262e-01 0.146 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.142262e-01 0.146 0 0
Signaling by FGFR in disease R-HSA-1226099 7.143940e-01 0.146 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 7.197767e-01 0.143 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.242821e-01 0.140 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 7.242821e-01 0.140 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 7.242821e-01 0.140 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 7.242821e-01 0.140 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 7.242821e-01 0.140 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 7.345722e-01 0.134 0 0
Diseases of DNA repair R-HSA-9675135 7.345722e-01 0.134 0 0
Ion homeostasis R-HSA-5578775 7.347476e-01 0.134 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 7.363087e-01 0.133 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 7.363087e-01 0.133 0 0
Polo-like kinase mediated events R-HSA-156711 7.363087e-01 0.133 0 0
Synaptic adhesion-like molecules R-HSA-8849932 7.363087e-01 0.133 0 0
Nephron development R-HSA-9831926 7.363087e-01 0.133 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.363087e-01 0.133 0 0
Voltage gated Potassium channels R-HSA-1296072 7.365507e-01 0.133 0 0
Leishmania infection R-HSA-9658195 7.365704e-01 0.133 0 0
Parasitic Infection Pathways R-HSA-9824443 7.365704e-01 0.133 0 0
HIV elongation arrest and recovery R-HSA-167287 7.425644e-01 0.129 0 0
Pausing and recovery of HIV elongation R-HSA-167290 7.425644e-01 0.129 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 7.425644e-01 0.129 0 0
Pyroptosis R-HSA-5620971 7.425644e-01 0.129 0 0
Protein localization R-HSA-9609507 7.438557e-01 0.129 0 0
CASP8 activity is inhibited R-HSA-5218900 7.449934e-01 0.128 0 0
Calcineurin activates NFAT R-HSA-2025928 7.449934e-01 0.128 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.449934e-01 0.128 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.449934e-01 0.128 0 0
Unwinding of DNA R-HSA-176974 7.449934e-01 0.128 0 0
mRNA Editing R-HSA-75072 7.449934e-01 0.128 0 0
ARMS-mediated activation R-HSA-170984 7.449934e-01 0.128 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.449934e-01 0.128 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.449934e-01 0.128 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.449934e-01 0.128 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.449934e-01 0.128 0 0
IRS-mediated signalling R-HSA-112399 7.478712e-01 0.126 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 7.486222e-01 0.126 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 7.498207e-01 0.125 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 7.518401e-01 0.124 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 7.521253e-01 0.124 0 0
Integration of energy metabolism R-HSA-163685 7.523983e-01 0.124 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 7.573022e-01 0.121 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 7.573022e-01 0.121 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 7.573022e-01 0.121 0 0
Specification of the neural plate border R-HSA-9834899 7.573022e-01 0.121 0 0
Rap1 signalling R-HSA-392517 7.573022e-01 0.121 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 7.598676e-01 0.119 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 7.598676e-01 0.119 0 0
Glucagon-type ligand receptors R-HSA-420092 7.598676e-01 0.119 0 0
Transcription of the HIV genome R-HSA-167172 7.602034e-01 0.119 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 7.605183e-01 0.119 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 7.605183e-01 0.119 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 7.624347e-01 0.118 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 7.669816e-01 0.115 0 0
RAS processing R-HSA-9648002 7.669816e-01 0.115 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.669816e-01 0.115 0 0
Plasma lipoprotein clearance R-HSA-8964043 7.669816e-01 0.115 0 0
OADH complex synthesizes glutaryl-CoA from 2-OA R-HSA-9858328 7.724497e-01 0.112 0 0
DNA replication initiation R-HSA-68952 7.724497e-01 0.112 0 0
Binding and entry of HIV virion R-HSA-173107 7.724497e-01 0.112 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.724497e-01 0.112 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.724497e-01 0.112 0 0
Receptor Mediated Mitophagy R-HSA-8934903 7.724497e-01 0.112 0 0
Tandem pore domain potassium channels R-HSA-1296346 7.724497e-01 0.112 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.724497e-01 0.112 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 7.726918e-01 0.112 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 7.738458e-01 0.111 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 7.762164e-01 0.110 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 7.768336e-01 0.110 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 7.768336e-01 0.110 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 7.768336e-01 0.110 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 7.768336e-01 0.110 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 7.768336e-01 0.110 0 0
HIV Transcription Elongation R-HSA-167169 7.811320e-01 0.107 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 7.811320e-01 0.107 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 7.811320e-01 0.107 0 0
Leishmania phagocytosis R-HSA-9664417 7.846497e-01 0.105 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 7.846497e-01 0.105 0 0
Parasite infection R-HSA-9664407 7.846497e-01 0.105 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.916022e-01 0.101 0 0
Trafficking of AMPA receptors R-HSA-399719 7.916390e-01 0.101 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.916390e-01 0.101 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 7.949744e-01 0.100 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.949744e-01 0.100 0 0
G-protein activation R-HSA-202040 7.949744e-01 0.100 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 7.949744e-01 0.100 0 0
ERK/MAPK targets R-HSA-198753 7.949744e-01 0.100 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.949744e-01 0.100 0 0
Aquaporin-mediated transport R-HSA-445717 7.956373e-01 0.099 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 7.969513e-01 0.099 0 0
DAG1 core M3 glycosylations R-HSA-8932505 7.969513e-01 0.099 0 0
vRNP Assembly R-HSA-192905 7.969513e-01 0.099 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 7.969513e-01 0.099 0 0
Chylomicron assembly R-HSA-8963888 7.969513e-01 0.099 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.969513e-01 0.099 0 0
Inwardly rectifying K+ channels R-HSA-1296065 8.061658e-01 0.094 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.061658e-01 0.094 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.073761e-01 0.093 0 0
Translation of Structural Proteins R-HSA-9683701 8.073761e-01 0.093 0 0
Mitochondrial biogenesis R-HSA-1592230 8.104090e-01 0.091 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 8.117975e-01 0.091 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 8.117975e-01 0.091 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.117975e-01 0.091 0 0
Attachment and Entry R-HSA-9694614 8.117975e-01 0.091 0 0
Mitochondrial calcium ion transport R-HSA-8949215 8.117975e-01 0.091 0 0
Immune System R-HSA-168256 8.128828e-01 0.090 0 0
Transmission across Chemical Synapses R-HSA-112315 8.138846e-01 0.089 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.186216e-01 0.087 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.188159e-01 0.087 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.188159e-01 0.087 0 0
ERKs are inactivated R-HSA-202670 8.188159e-01 0.087 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.188159e-01 0.087 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 8.188159e-01 0.087 0 0
Activation of GABAB receptors R-HSA-991365 8.195046e-01 0.086 0 0
GABA B receptor activation R-HSA-977444 8.195046e-01 0.086 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 8.198292e-01 0.086 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 8.198292e-01 0.086 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 8.198292e-01 0.086 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.269326e-01 0.083 0 0
FGFR2 alternative splicing R-HSA-6803529 8.273764e-01 0.082 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 8.273764e-01 0.082 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 8.273764e-01 0.082 0 0
Signaling by KIT in disease R-HSA-9669938 8.273764e-01 0.082 0 0
Ethanol oxidation R-HSA-71384 8.273764e-01 0.082 0 0
Neddylation R-HSA-8951664 8.281769e-01 0.082 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.317218e-01 0.080 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.326633e-01 0.080 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.349470e-01 0.078 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 8.383272e-01 0.077 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 8.383272e-01 0.077 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 8.383272e-01 0.077 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.383272e-01 0.077 0 0
Beta oxidation of myristoyl-CoA to lauroyl-CoA R-HSA-77285 8.383272e-01 0.077 0 0
Maple Syrup Urine Disease R-HSA-9865114 8.383272e-01 0.077 0 0
Beta oxidation of palmitoyl-CoA to myristoyl-CoA R-HSA-77305 8.383272e-01 0.077 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 8.383272e-01 0.077 0 0
Repression of WNT target genes R-HSA-4641265 8.383272e-01 0.077 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.383272e-01 0.077 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.383272e-01 0.077 0 0
MET activates RAS signaling R-HSA-8851805 8.383272e-01 0.077 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.383272e-01 0.077 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.383272e-01 0.077 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 8.417837e-01 0.075 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 8.417837e-01 0.075 0 0
Formation of the ureteric bud R-HSA-9830674 8.417837e-01 0.075 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 8.417837e-01 0.075 0 0
Amine ligand-binding receptors R-HSA-375280 8.418722e-01 0.075 0 0
G alpha (z) signalling events R-HSA-418597 8.425934e-01 0.074 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 8.447027e-01 0.073 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 8.447027e-01 0.073 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.447027e-01 0.073 0 0
Hyaluronan metabolism R-HSA-2142845 8.447027e-01 0.073 0 0
Calnexin/calreticulin cycle R-HSA-901042 8.447027e-01 0.073 0 0
Fanconi Anemia Pathway R-HSA-6783310 8.521530e-01 0.069 0 0
Adipogenesis R-HSA-9843745 8.521732e-01 0.069 0 0
Kidney development R-HSA-9830369 8.537933e-01 0.069 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 8.550912e-01 0.068 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 8.550912e-01 0.068 0 0
Thromboxane signalling through TP receptor R-HSA-428930 8.550912e-01 0.068 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.550912e-01 0.068 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.557385e-01 0.068 0 0
OGDH complex synthesizes succinyl-CoA from 2-OG R-HSA-9853506 8.557385e-01 0.068 0 0
Processing of SMDT1 R-HSA-8949664 8.557385e-01 0.068 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.557385e-01 0.068 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.557385e-01 0.068 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.557385e-01 0.068 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.557385e-01 0.068 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 8.557385e-01 0.068 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.557385e-01 0.068 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.557385e-01 0.068 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.557385e-01 0.068 0 0
Maturation of nucleoprotein R-HSA-9683610 8.557385e-01 0.068 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.557385e-01 0.068 0 0
Signalling to ERKs R-HSA-187687 8.559828e-01 0.068 0 0
Nuclear Receptor transcription pathway R-HSA-383280 8.567014e-01 0.067 0 0
Integrin cell surface interactions R-HSA-216083 8.567014e-01 0.067 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.665392e-01 0.062 0 0
RNA Polymerase III Transcription R-HSA-74158 8.665392e-01 0.062 0 0
RUNX2 regulates bone development R-HSA-8941326 8.665392e-01 0.062 0 0
G1/S-Specific Transcription R-HSA-69205 8.665392e-01 0.062 0 0
Triglyceride catabolism R-HSA-163560 8.665392e-01 0.062 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 8.673685e-01 0.062 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.673685e-01 0.062 0 0
Hyaluronan degradation R-HSA-2160916 8.673685e-01 0.062 0 0
Regulation of insulin secretion R-HSA-422356 8.707502e-01 0.060 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 8.712755e-01 0.060 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 8.712755e-01 0.060 0 0
CRMPs in Sema3A signaling R-HSA-399956 8.712755e-01 0.060 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.712755e-01 0.060 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.712755e-01 0.060 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 8.712755e-01 0.060 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.712755e-01 0.060 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.712755e-01 0.060 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.712755e-01 0.060 0 0
Stimuli-sensing channels R-HSA-2672351 8.744060e-01 0.058 0 0
Amino acid transport across the plasma membrane R-HSA-352230 8.774185e-01 0.057 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 8.785793e-01 0.056 0 0
MET activates PTK2 signaling R-HSA-8874081 8.786832e-01 0.056 0 0
TRP channels R-HSA-3295583 8.786832e-01 0.056 0 0
Urea cycle R-HSA-70635 8.786832e-01 0.056 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 8.786832e-01 0.056 0 0
NGF-stimulated transcription R-HSA-9031628 8.796470e-01 0.056 0 0
Metabolism of polyamines R-HSA-351202 8.850245e-01 0.053 0 0
Hemostasis R-HSA-109582 8.851017e-01 0.053 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.851400e-01 0.053 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 8.851400e-01 0.053 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.851400e-01 0.053 0 0
Signaling by Activin R-HSA-1502540 8.851400e-01 0.053 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.851400e-01 0.053 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.851400e-01 0.053 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 8.851400e-01 0.053 0 0
Protein lipoylation R-HSA-9857492 8.851400e-01 0.053 0 0
Beta oxidation of butanoyl-CoA to acetyl-CoA R-HSA-77352 8.851400e-01 0.053 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 8.851400e-01 0.053 0 0
Other semaphorin interactions R-HSA-416700 8.851400e-01 0.053 0 0
Formation of the anterior neural plate R-HSA-9823739 8.851400e-01 0.053 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.856222e-01 0.053 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 8.877702e-01 0.052 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 8.891001e-01 0.051 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.891001e-01 0.051 0 0
Signaling by BMP R-HSA-201451 8.891001e-01 0.051 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.891001e-01 0.051 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 8.912097e-01 0.050 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.915637e-01 0.050 0 0
Pentose phosphate pathway R-HSA-71336 8.942183e-01 0.049 0 0
Disease R-HSA-1643685 8.943083e-01 0.049 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 8.975120e-01 0.047 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.975120e-01 0.047 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.975120e-01 0.047 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.975120e-01 0.047 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 8.975120e-01 0.047 0 0
Fructose catabolism R-HSA-70350 8.975120e-01 0.047 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 8.975120e-01 0.047 0 0
Attachment and Entry R-HSA-9678110 8.975120e-01 0.047 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.986814e-01 0.046 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.986814e-01 0.046 0 0
Telomere Extension By Telomerase R-HSA-171319 8.986814e-01 0.046 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 8.986814e-01 0.046 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.000383e-01 0.046 0 0
Post-translational protein modification R-HSA-597592 9.006863e-01 0.045 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.022294e-01 0.045 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 9.022294e-01 0.045 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 9.022294e-01 0.045 0 0
Mitochondrial protein degradation R-HSA-9837999 9.039204e-01 0.044 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.054569e-01 0.043 0 0
mRNA Capping R-HSA-72086 9.074860e-01 0.042 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.074860e-01 0.042 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 9.074860e-01 0.042 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 9.085519e-01 0.042 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.085519e-01 0.042 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.085519e-01 0.042 0 0
Fibronectin matrix formation R-HSA-1566977 9.085519e-01 0.042 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 9.085519e-01 0.042 0 0
Heme assimilation R-HSA-9927020 9.085519e-01 0.042 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 9.085519e-01 0.042 0 0
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids R-HSA-77288 9.085519e-01 0.042 0 0
Glycine degradation R-HSA-6783984 9.085519e-01 0.042 0 0
Phase 2 - plateau phase R-HSA-5576893 9.085519e-01 0.042 0 0
Passive transport by Aquaporins R-HSA-432047 9.085519e-01 0.042 0 0
Synthesis of PG R-HSA-1483148 9.085519e-01 0.042 0 0
Galactose catabolism R-HSA-70370 9.085519e-01 0.042 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.093281e-01 0.041 0 0
Maturation of spike protein R-HSA-9694548 9.096884e-01 0.041 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.153005e-01 0.038 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.155702e-01 0.038 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 9.155702e-01 0.038 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.155702e-01 0.038 0 0
Neurotransmitter clearance R-HSA-112311 9.155702e-01 0.038 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.155702e-01 0.038 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.156497e-01 0.038 0 0
HIV Transcription Initiation R-HSA-167161 9.166270e-01 0.038 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.166270e-01 0.038 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.166270e-01 0.038 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.166270e-01 0.038 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.184033e-01 0.037 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.184033e-01 0.037 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.184033e-01 0.037 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 9.184033e-01 0.037 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 9.184033e-01 0.037 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 9.184033e-01 0.037 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.184033e-01 0.037 0 0
Catecholamine biosynthesis R-HSA-209905 9.184033e-01 0.037 0 0
Choline catabolism R-HSA-6798163 9.184033e-01 0.037 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.184033e-01 0.037 0 0
Platelet homeostasis R-HSA-418346 9.191828e-01 0.037 0 0
Cargo concentration in the ER R-HSA-5694530 9.229869e-01 0.035 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.229869e-01 0.035 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.230761e-01 0.035 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.244067e-01 0.034 0 0
Paracetamol ADME R-HSA-9753281 9.271229e-01 0.033 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 9.271939e-01 0.033 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.271939e-01 0.033 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.271939e-01 0.033 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.277261e-01 0.033 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.290652e-01 0.032 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.296875e-01 0.032 0 0
SLC transporter disorders R-HSA-5619102 9.311841e-01 0.031 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.350379e-01 0.029 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.350379e-01 0.029 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.350379e-01 0.029 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.350379e-01 0.029 0 0
Other interleukin signaling R-HSA-449836 9.350379e-01 0.029 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.350379e-01 0.029 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 9.360148e-01 0.029 0 0
Cardiogenesis R-HSA-9733709 9.360148e-01 0.029 0 0
Ion channel transport R-HSA-983712 9.374825e-01 0.028 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.397761e-01 0.027 0 0
Resolution of D-Loop Structures R-HSA-5693537 9.417168e-01 0.026 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.417168e-01 0.026 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.420372e-01 0.026 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.420372e-01 0.026 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.420372e-01 0.026 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.420372e-01 0.026 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.420372e-01 0.026 0 0
Creatine metabolism R-HSA-71288 9.420372e-01 0.026 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.420372e-01 0.026 0 0
Pregnenolone biosynthesis R-HSA-196108 9.420372e-01 0.026 0 0
tRNA processing R-HSA-72306 9.427770e-01 0.026 0 0
Signaling by Insulin receptor R-HSA-74752 9.437851e-01 0.025 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.445509e-01 0.025 0 0
Cardiac conduction R-HSA-5576891 9.451747e-01 0.024 0 0
ECM proteoglycans R-HSA-3000178 9.451993e-01 0.024 0 0
Peroxisomal protein import R-HSA-9033241 9.459413e-01 0.024 0 0
Triglyceride metabolism R-HSA-8979227 9.459413e-01 0.024 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.469334e-01 0.024 0 0
Signal amplification R-HSA-392518 9.469334e-01 0.024 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.482828e-01 0.023 0 0
Signalling to RAS R-HSA-167044 9.482828e-01 0.023 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.482828e-01 0.023 0 0
GABA receptor activation R-HSA-977443 9.498933e-01 0.022 0 0
tRNA Aminoacylation R-HSA-379724 9.498933e-01 0.022 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.498933e-01 0.022 0 0
Formation of the cornified envelope R-HSA-6809371 9.507742e-01 0.022 0 0
PERK regulates gene expression R-HSA-381042 9.517029e-01 0.021 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.524178e-01 0.021 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.538557e-01 0.021 0 0
Serine metabolism R-HSA-977347 9.538557e-01 0.021 0 0
Glutathione synthesis and recycling R-HSA-174403 9.538557e-01 0.021 0 0
PPARA activates gene expression R-HSA-1989781 9.560465e-01 0.020 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.560611e-01 0.020 0 0
Glycosphingolipid transport R-HSA-9845576 9.560611e-01 0.020 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.588284e-01 0.018 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.588284e-01 0.018 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.588284e-01 0.018 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 9.588284e-01 0.018 0 0
Fructose metabolism R-HSA-5652084 9.588284e-01 0.018 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.588284e-01 0.018 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.600412e-01 0.018 0 0
Lysine catabolism R-HSA-71064 9.600412e-01 0.018 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.603404e-01 0.018 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.603412e-01 0.018 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.632655e-01 0.016 0 0
Interleukin-20 family signaling R-HSA-8854691 9.632655e-01 0.016 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.632655e-01 0.016 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.632655e-01 0.016 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.632655e-01 0.016 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.632655e-01 0.016 0 0
The phototransduction cascade R-HSA-2514856 9.635684e-01 0.016 0 0
Elastic fibre formation R-HSA-1566948 9.636740e-01 0.016 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.640093e-01 0.016 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.640707e-01 0.016 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.665477e-01 0.015 0 0
Interleukin-10 signaling R-HSA-6783783 9.668324e-01 0.015 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.672246e-01 0.014 0 0
Complex III assembly R-HSA-9865881 9.672246e-01 0.014 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.672246e-01 0.014 0 0
G alpha (s) signalling events R-HSA-418555 9.678710e-01 0.014 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.700103e-01 0.013 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.707572e-01 0.013 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.707572e-01 0.013 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.707572e-01 0.013 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.739093e-01 0.011 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 9.739093e-01 0.011 0 0
Sphingolipid catabolism R-HSA-9845614 9.739093e-01 0.011 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.767217e-01 0.010 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.767217e-01 0.010 0 0
Triglyceride biosynthesis R-HSA-75109 9.767217e-01 0.010 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.767217e-01 0.010 0 0
Pyrimidine salvage R-HSA-73614 9.792312e-01 0.009 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.805247e-01 0.009 0 0
Extracellular matrix organization R-HSA-1474244 9.813366e-01 0.008 0 0
Thyroxine biosynthesis R-HSA-209968 9.814702e-01 0.008 0 0
Platelet calcium homeostasis R-HSA-418360 9.814702e-01 0.008 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.817893e-01 0.008 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.828342e-01 0.008 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.831118e-01 0.007 0 0
mitochondrial fatty acid beta-oxidation of saturated fatty acids R-HSA-77286 9.832522e-01 0.007 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 9.834680e-01 0.007 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.857496e-01 0.006 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.860416e-01 0.006 0 0
Synthesis of PC R-HSA-1483191 9.862392e-01 0.006 0 0
DAG1 glycosylations R-HSA-8931838 9.868409e-01 0.006 0 0
HS-GAG degradation R-HSA-2024096 9.868409e-01 0.006 0 0
Metal ion SLC transporters R-HSA-425410 9.875314e-01 0.005 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.876057e-01 0.005 0 0
Innate Immune System R-HSA-168249 9.879308e-01 0.005 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.882599e-01 0.005 0 0
Recycling of bile acids and salts R-HSA-159418 9.882599e-01 0.005 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.887049e-01 0.005 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.894837e-01 0.005 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.895259e-01 0.005 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.895259e-01 0.005 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.895259e-01 0.005 0 0
Heme degradation R-HSA-189483 9.895259e-01 0.005 0 0
Azathioprine ADME R-HSA-9748787 9.897705e-01 0.004 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.897705e-01 0.004 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.902063e-01 0.004 0 0
Interferon gamma signaling R-HSA-877300 9.903165e-01 0.004 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.906555e-01 0.004 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.906555e-01 0.004 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.908875e-01 0.004 0 0
Collagen formation R-HSA-1474290 9.916423e-01 0.004 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.916634e-01 0.004 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.916634e-01 0.004 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.916634e-01 0.004 0 0
G alpha (q) signalling events R-HSA-416476 9.923417e-01 0.003 0 0
HS-GAG biosynthesis R-HSA-2022928 9.925625e-01 0.003 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.925625e-01 0.003 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.925625e-01 0.003 0 0
Metabolism of proteins R-HSA-392499 9.930686e-01 0.003 0 0
COPII-mediated vesicle transport R-HSA-204005 9.932234e-01 0.003 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.933648e-01 0.003 0 0
Metabolism of folate and pterines R-HSA-196757 9.933648e-01 0.003 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.934262e-01 0.003 0 0
Metabolism of cofactors R-HSA-8978934 9.938164e-01 0.003 0 0
Purine salvage R-HSA-74217 9.940805e-01 0.003 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.943813e-01 0.002 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.947191e-01 0.002 0 0
Dectin-2 family R-HSA-5621480 9.949189e-01 0.002 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.950014e-01 0.002 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.952888e-01 0.002 0 0
Iron uptake and transport R-HSA-917937 9.957239e-01 0.002 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.957971e-01 0.002 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.957971e-01 0.002 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.962340e-01 0.002 0 0
RAB geranylgeranylation R-HSA-8873719 9.962466e-01 0.002 0 0
Glutathione conjugation R-HSA-156590 9.962466e-01 0.002 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.962506e-01 0.002 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.963005e-01 0.002 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.963005e-01 0.002 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.966552e-01 0.001 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.967655e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.972318e-01 0.001 0 0
Phospholipid metabolism R-HSA-1483257 9.973208e-01 0.001 0 0
Methylation R-HSA-156581 9.973381e-01 0.001 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.974998e-01 0.001 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.976254e-01 0.001 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.976254e-01 0.001 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.976751e-01 0.001 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.979614e-01 0.001 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.983143e-01 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.983388e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.984963e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.987794e-01 0.001 0 0
Retinoid metabolism and transport R-HSA-975634 9.987794e-01 0.001 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.988034e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.988034e-01 0.001 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.988034e-01 0.001 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.988258e-01 0.001 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.989484e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.990068e-01 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 9.990479e-01 0.000 0 0
Neurotransmitter release cycle R-HSA-112310 9.990561e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.991147e-01 0.000 0 0
Glucuronidation R-HSA-156588 9.991507e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.991922e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.994081e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.994979e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.995204e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.995667e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.996184e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.996184e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.996749e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.997686e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.998013e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.998078e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.998078e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.998286e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.998637e-01 0.000 0 0
Keratinization R-HSA-6805567 9.998736e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.998743e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.998784e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.998784e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999002e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999124e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.999137e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999289e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999425e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.999513e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999513e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999575e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999732e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999800e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999847e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999945e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999978e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999979e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999984e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999991e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999992e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999996e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999998e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999998e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999998e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999998e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999999e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999999e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999999e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999999e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999999e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999999e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways