NDR2

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

Log-Odds: S Sites / S Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
O00488	S98	Sugiyama	ZNF593 ZT86	THFRSKDHKKRLKQLsVEPysQEEAERAAGMGSYVPPRRLA
O60285	T211	EPSD\|PSP	NUAK1 ARK5 KIAA0537 OMPHK1	NIKIADFGLSNLYQKDKFLQtFCGSPLYASPEIVNGRPYRG
O60814	S37	Sugiyama	H2BC12 H2BFT HIRIP1 HIST1H2BK	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
O75385	S495	SIGNOR\|PSP	ULK1 KIAA0722	RAsPsPPAHAEHGGVLARKMsLGGGRPYTPSPQVGTIPERP
P00338	S161	Sugiyama	LDHA PIG19	DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P04075	S36	Sugiyama	ALDOA ALDA	LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075	S46	Sugiyama	ALDOA ALDA	PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04406	S241	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04792	S83	Sugiyama	HSPB1 HSP27 HSP28	IEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNH
P06899	S37	Sugiyama	H2BC11 H2BFR HIST1H2BJ	KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISS
P07195	S162	Sugiyama	LDHB	DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07814	S335	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	PIEKNLQMWEEMKKGsQFGQsCCLRAKIDMSSNNGCMRDPt
P07864	S161	Sugiyama	LDHC LDH3 LDHX	DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900	S53	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P07900	Y284	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	DEEEEKKDGDKKKKKKIKEKyIDQEELNKtKPIWtRNPDDI
P08238	Y276	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	DEEDDsGKDKKKKTKKIKEKyIDQEELNKtKPIWtRNPDDI
P0CG47	S57	Sugiyama	UBB	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0CG48	S57	Sugiyama	UBC	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0DPH7	S48	Sugiyama	TUBA3C TUBA2	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P10412	S36	Sugiyama	H1-4 H1F4 HIST1H1E	EKtPVKKKARKsAGAAKRKAsGPPVsELItKAVAASKERsG
P10412	S55	Sugiyama	H1-4 H1F4 HIST1H1E	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P13639	S23	Sugiyama	EEF2 EF2	NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639	S593	Sugiyama	EEF2 EF2	SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P14314	S126	Sugiyama	PRKCSH G19P1	yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P15531	S120	Sugiyama	NME1 NDPKA NM23	KPGtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELV
P16402	S37	Sugiyama	H1-3 H1F3 HIST1H1D	KtPVKKKAKKAGATAGKRKAsGPPVsELItKAVAASKERsG
P16402	S56	Sugiyama	H1-3 H1F3 HIST1H1D	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403	S55	Sugiyama	H1-2 H1F2 HIST1H1C	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P22059	S190	Sugiyama	OSBP OSBP1	QRWVTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNT
P22059	S193	Sugiyama	OSBP OSBP1	VTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNTLRT
P22090	S204	Sugiyama	RPS4Y1 RPS4Y PRO2646	IGGANLGRVGVITNRERHPGsFDVVHVKDANGNSFATRLSN
P23527	S37	Sugiyama	H2BC17 H2BFH H2BFN HIST1H2BO	KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISS
P23588	S122	Sugiyama	EIF4B	NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P26038	S576	Sugiyama	MSN	YKtLRQIRQGNTKQRIDEFEsM___________________
P26038	T526	Sugiyama	MSN	EERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHA
P30086	S54	Sugiyama	PEBP1 PBP PEBP	VDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPDAP
P31948	S16	Sugiyama	STIP1	_____MEQVNELKEKGNKALsVGNIDDALQCysEAIKLDPH
P33316	S120	Sugiyama	DUT	PsKRARPAEVGGMQLRFARLsEHAtAPTRGsARAAGYDLYS
P33316	S164	Sugiyama	DUT	YTIPPMEKAVVKTDIQIALPsGCyGRVAPRSGLAAKHFIDV
P33778	S37	Sugiyama	H2BC3 H2BFF HIST1H2BB	KAITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISS
P35637	S360	Sugiyama	FUS TLS	sFDDPPsAKAAIDWFDGKEFsGNPIKVsFATRRADFNRGGG
P36578	S87	Sugiyama	RPL4 RPL1	WGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAPTKT
P37802	S163	Sugiyama	TAGLN2 KIAA0120 CDABP0035	LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802	S185	Sugiyama	TAGLN2 KIAA0120 CDABP0035	NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P38646	S89	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P43034	S152	Sugiyama	PAFAH1B1 LIS1 MDCR MDS PAFAHA	IKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADM
P43243	S188	Sugiyama	MATR3 KIAA0723	EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P46776	S68	Sugiyama	RPL27A	yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777	S224	Sugiyama	RPL5 MSTP030	VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46937	S109	Sugiyama	YAP1 YAP65	RKLPDsFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssP
P46937	S127	EPSD\|PSP	YAP1 YAP65	QAstDAGtAGALtPQHVRAHssPAsLQLGAVsPGtLtPtGV
P46937	T114	Sugiyama	YAP1 YAP65	sFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssPAsLQL
P47712	S727	Sugiyama	PLA2G4A CPLA2 PLA2G4	VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P49321	S659	Sugiyama	NASP	IEELKELLPEIREKIEDAKEsQRsGNVAELALKATLVEsst
P50990	S23	Sugiyama	CCT8 C21orf112 CCTQ KIAA0002	LHVPKAPGFAQMLKEGAKHFsGLEEAVyRNIQACKELAQTT
P50991	T50	Sugiyama	CCT4 CCTD SRB	PAQIRFsNISAAKAVADAIRtsLGPKGMDKMIQDGKGDVtI
P51116	S601	Sugiyama	FXR2 FMR1L2	RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51532	S1380	Sugiyama	SMARCA4 BAF190A BRG1 SNF2B SNF2L4	EEEEEKMFGRGSRHRKEVDYsDsLTEKQWLKAIEEGtLEEI
P51532	S1382	Sugiyama	SMARCA4 BAF190A BRG1 SNF2B SNF2L4	EEEKMFGRGSRHRKEVDYsDsLTEKQWLKAIEEGtLEEIEE
P51858	S83	Sugiyama	HDGF HMG1L2	LFPyEEsKEKFGKPNKRKGFsEGLWEIENNPtVKASGYQSs
P52209	S126	Sugiyama	PGD PGDH	YRDTTRRCRDLKAKGILFVGsGVsGGEEGARyGPSLMPGGN
P53396	S455	Sugiyama	ACLY	ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P57053	S37	Sugiyama	H2BC12L H2BFS H2BS1	KAVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIss
P57721	S82	Sugiyama	PCBP3 PCBP3-OT1 PCBP3OT	GKKGETVKKMREESGARINIsEGNCPERIVTITGPTDAIFK
P58876	S37	Sugiyama	H2BC5 H2BFB HIRIP2 HIST1H2BD	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
P60174	S212	Sugiyama	TPI1 TPI	WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709	S52	Sugiyama	ACTB	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258	S148	Sugiyama	YWHAE	YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62263	S137	Sugiyama	RPS14 PRO2640	RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62273	S9	Sugiyama	RPS29	____________MGHQQLyWsHPRKFGQGSRSCRVCSNRHG
P62273	Y7	Sugiyama	RPS29	______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62701	S204	Sugiyama	RPS4X CCG2 RPS4 SCAR	tGGANLGRIGVITNRERHPGsFDVVHVKDANGNSFATRLsN
P62736	S54	Sugiyama	ACTA2 ACTSA ACTVS GIG46	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62807	S37	Sugiyama	H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI	KAVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIss
P62899	S15	Sugiyama	RPL31	______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62917	S130	Sugiyama	RPL8	GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917	T146	Sugiyama	RPL8	LARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVISSANRAVV
P62917	Y133	Sugiyama	RPL8	VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62937	S51	Sugiyama	PPIA CYPA	KtAENFRALSTGEKGFGYKGsCFHRIIPGFMCQGGDFtRHN
P62979	S123	Sugiyama	RPS27A UBA80 UBCEP1	LKYYKVDENGKIsRLRRECPsDECGAGVFMAsHFDRHyCGK
P62979	S57	Sugiyama	RPS27A UBA80 UBCEP1	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGA
P62987	S57	Sugiyama	UBA52 UBCEP2	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGI
P63261	S52	Sugiyama	ACTG1 ACTG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63267	S53	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P67809	S102	Sugiyama	YBX1 NSEP1 YB1	EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P67809	S209	Sugiyama	YBX1 NSEP1 YB1	RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P67809	Y196	Sugiyama	YBX1 NSEP1 YB1	sAPEGQAQQRRPyRRRRFPPyyMRRPYGRRPQysNPPVQGE
P67809	Y197	Sugiyama	YBX1 NSEP1 YB1	APEGQAQQRRPyRRRRFPPyyMRRPYGRRPQysNPPVQGEV
P67809	Y99	Sugiyama	YBX1 NSEP1 YB1	DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
P68032	S54	Sugiyama	ACTC1 ACTC	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133	S54	Sugiyama	ACTA1 ACTA	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68363	S48	Sugiyama	TUBA1B	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P83731	S38	Sugiyama	RPL24	GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
Q01105	S161	Sugiyama	SET	FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q07021	S106	Sugiyama	C1QBP GC1QBP HABP1 SF2P32	LsDEIKEERKIQKHKTLPKMsGGWELELNGTEAKLVRKVAG
Q08945	S657	Sugiyama	SSRP1 FACT80	MEKKSTPSRGsSSKSsSRQLsEsFKSKEFVssDEsssGENK
Q13247	S297	Sugiyama	SRSF6 SFRS6 SRP55	RSRSPKENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsP
Q13247	S301	Sugiyama	SRSF6 SFRS6 SRP55	PKENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKR
Q13283	S67	Sugiyama	G3BP1 G3BP	sNGKPADAVyGQKEIHRKVMsQNFtNCHTKIRHVDAHATLN
Q13442	S19	Sugiyama	PDAP1 HASPP28	__MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEEE
Q13442	T18	Sugiyama	PDAP1 HASPP28	___MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEE
Q13442	Y17	Sugiyama	PDAP1 HASPP28	____MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREE
Q14103	S271	Sugiyama	HNRNPD AUF1 HNRPD	KCEIKVAMSKEQyQQQQQWGsRGGFAGRARGRGGGPSQNWN
Q14152	S584	Sugiyama	EIF3A EIF3S10 KIAA0139	EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14432	T311	Sugiyama	PDE3A	RsssVVsAEMSGCSSKSHRRtsLPCIPREQLMGHSEWDHKR
Q14568	S53	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14568	Y283	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	sDEEEEKKDGDKKKKKTKEKyIDQEELNKTKPIWTRNPDDI
Q14653	S396	PSP	IRF3	VEMARVGGAssLENtVDLHIsNsHPLsLtsDQYKAYLQDLV
Q14738	S573	Sugiyama	PPP2R5D	TEAVQMLKDIKKEKVLLRRKsELPQDVyTIKALEAHKRAEE
Q14978	S686	Sugiyama	NOLC1 KIAA0035 NS5ATP13	KGKSFRHEKTKKKRGsYRGGsIsVQVNsIKFDsE_______
Q15293	Y115	Sugiyama	RCN1 RCN	GDGFVttEELKtWIKRVQKRyIFDNVAKVWKDYDRDKDDKI
Q15365	S50	Sugiyama	PCBP1	GKKGESVKRIREEsGARINIsEGNCPERIItLTGPTNAIFK
Q15366	S50	Sugiyama	PCBP2	GKKGESVKKMREESGARINIsEGNCPERIITLAGPTNAIFK
Q16778	S37	Sugiyama	H2BC21 H2BFQ HIST2H2BE	KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIss
Q58FF8	Y198	Sugiyama	HSP90AB2P HSP90BB	DEEDDsGKDKKKKTKKIKEKyIDQEELNKTKPIWTRNTEDI
Q5QNW6	S37	Sugiyama	H2BC18 HIST2H2BF	KAVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q5T5C0	S692	Sugiyama	STXBP5 LLGL3	YGSNDPYRREPRSPRKsRQPsGAGLCDIsEGtVVPEDRCKS
Q6DD87	S104	Sugiyama	ZNF787	HQRTHtGERPNACADCGKTFsQSSHLVQHRRIHtGEKPYAC
Q6DN03	S37	Sugiyama	H2BC20P HIST2H2BC	KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWC
Q6DRA6	S37	Sugiyama	H2BC19P HIST2H2BD	KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWC
Q6P158	S70	Sugiyama	DHX57	NRKAssRIWDDGDDFCIFSEsRRPsRPsNSNISKGESRPKW
Q6PEY2	S48	Sugiyama	TUBA3E	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q6ZMR3	S161	Sugiyama	LDHAL6A LDHL2	DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q6ZVN8	T290	Sugiyama	HJV HFE2 RGMC	PGNHVEIQAAYIGTTIIIRQtAGQLSFSIKVAEDVAMAFSA
Q71U36	S48	Sugiyama	TUBA1A TUBA3	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q7KZ85	S1668	Sugiyama	SUPT6H KIAA0162 SPT6H	QAQPQPSSSSRQRQQQPKsNsHAAIDWGKMAEQWLQEKEAE
Q7Z4V5	S454	Sugiyama	HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604	VRPEEKQQAKPVKVERTRKRsEGFsMDRKVEKKKEPSVEEK
Q86VQ1	S223	Sugiyama	GLCCI1	QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q8N257	S37	Sugiyama	H2BC26 H2BU1 HIST3H2BB	KAVTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIss
Q8NFD5	S1744	Sugiyama	ARID1B BAF250B DAN15 KIAA1235 OSA2	ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q8TAM6	S280	Sugiyama	ERMN KIAA1189	TISYRKIRKGNTKQRIDEFEsMMHL________________
Q92597	S332	Sugiyama	NDRG1 CAP43 DRG1 RTP	MGYMPsAsMtRLMRsRtAsGssVtsLDGtRsRsHtSEGTRs
Q93079	S37	Sugiyama	H2BC9 H2BFJ HIST1H2BH	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q96QF0	S288	EPSD\|PSP	RAB3IP RABIN8	tQEPLPGGKTPFKKGHTRNKstssAMsGsHQDLSVIQPIVK
Q99570	S853	Sugiyama	PIK3R4 VPS15	LVKTKQEPDDKRARKHVKQDsNVNEEWKsMFGsLDPPNMPQ
Q99877	S37	Sugiyama	H2BC15 H2BFD HIST1H2BN	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99879	S37	Sugiyama	H2BC14 H2BFE HIST1H2BM	KAINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99880	S37	Sugiyama	H2BC13 H2BFC HIST1H2BL	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q9BQE3	S48	Sugiyama	TUBA1C TUBA6	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9BTU6	S462	Sugiyama	PI4K2A	HLVQMPPVIVETARSHQRsssEsyTQsFQSRKPFFSWW___
Q9GZL7	S206	Sugiyama	WDR12	RGHAGSVDSIAVDGSGTKFCsGSWDKMLKIWStVPtDEEDE
Q9H4A3	T2245	Sugiyama	WNK1 HSN2 KDP KIAA0344 PRKWNK1	TVNSQAAQAQPPAMTSSRKGtFtDDLHKLVDNWARDAMNLS
Q9H4A3	T2247	Sugiyama	WNK1 HSN2 KDP KIAA0344 PRKWNK1	NSQAAQAQPPAMTSSRKGtFtDDLHKLVDNWARDAMNLSGR
Q9NWS0	S173	Sugiyama	PIH1D1 NOP17	KYNLQLNPEWRMMKNRPFMGsIsQQNIRSEQRPRIQELGDL
Q9P0L0	S166	Sugiyama	VAPA VAP33	KAVPLNASKQDGPMPKPHsVsLNDtEtRKLMEECKRLQGEM
Q9UGV2	T332	Sugiyama	NDRG3	GMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQs
Q9UI15	S185	Sugiyama	TAGLN3 NP25	EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UPQ0	S201	Sugiyama	LIMCH1 KIAA1102	DCWDsERsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVV
Q9UPT8	S137	Sugiyama	ZC3H4 C19orf7 KIAA1064	RSKKRRKSKHKRHAsSSDDFsDFsDDsDFsPSEKGHRKyRE
Q9UQ35	S2692	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9UQ35	S854	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sHSsssPHPKVKsGtPPRQGsItsPQANEQsVtPQRRsCFE
Q9Y2B0	S63	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	AQVDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLE
Q9Y2B0	S65	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2H1	S282	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	STK38L KIAA0965 NDR2	NMNsKRKAETWKKNRRQLAystVGtPDyIAPEVFMQTGYNK
Q9Y2H1	S372	Sugiyama	STK38L KIAA0965 NDR2	EKAKDLILRFCIDSENRIGNsGVEEIKGHPFFEGVDWEHIR
Q9Y2H1	S454	Sugiyama	STK38L KIAA0965 NDR2	KDWVFLNytYKRFEGLtQRGsIPTYMKAGKL__________
Q9Y2H1	Y441	Sugiyama	STK38L KIAA0965 NDR2	QPVPNTTEPDYKSKDWVFLNytYKRFEGLtQRGsIPTYMKA
Q9Y3S1	T2157	Sugiyama	WNK2 KIAA1760 PRKWNK2 SDCCAG43 P/OKcl.13	GPQPALHVQAQVNNSNNKKGtFtDDLHKLVDEWTSKTVGAA
Q9Y3S1	T2159	Sugiyama	WNK2 KIAA1760 PRKWNK2 SDCCAG43 P/OKcl.13	QPALHVQAQVNNSNNKKGtFtDDLHKLVDEWTSKTVGAAQL
Q9Y3U8	S91	Sugiyama	RPL36	KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Q9Y5U2	S86	Sugiyama	TSSC4	PSPPSGLLPATVQPFHLRGMssTFSQRsRDIFDCLEGAARR

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	0.000001	5.975
Chromatin modifying enzymes	R-HSA-3247509	0.000024	4.625
Chromatin organization	R-HSA-4839726	0.000026	4.581
Axon guidance	R-HSA-422475	0.000028	4.558
mRNA Splicing	R-HSA-72172	0.000037	4.430
mRNA Splicing - Major Pathway	R-HSA-72163	0.000049	4.309
Nervous system development	R-HSA-9675108	0.000064	4.197
Apoptotic cleavage of cellular proteins	R-HSA-111465	0.000066	4.183
HSF1-dependent transactivation	R-HSA-3371571	0.000072	4.141
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	0.000073	4.134
Signaling by ROBO receptors	R-HSA-376176	0.000120	3.920
Signaling by Hippo	R-HSA-2028269	0.000136	3.866
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	0.000153	3.814
Attenuation phase	R-HSA-3371568	0.000174	3.760
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	0.000226	3.646
Cellular response to heat stress	R-HSA-3371556	0.000293	3.533
Transcriptional regulation by RUNX1	R-HSA-8878171	0.000290	3.538
Transcriptional Regulation by E2F6	R-HSA-8953750	0.000448	3.349
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	0.000472	3.326
Gene expression (Transcription)	R-HSA-74160	0.000501	3.301
Specification of primordial germ cells	R-HSA-9827857	0.000612	3.213
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	0.000666	3.177
RET signaling	R-HSA-8853659	0.000747	3.127
Formation of RNA Pol II elongation complex	R-HSA-112382	0.000746	3.127
RNA Polymerase II Transcription Elongation	R-HSA-75955	0.000885	3.053
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	0.001012	2.995
Germ layer formation at gastrulation	R-HSA-9754189	0.001117	2.952
Activation of RAC1	R-HSA-428540	0.001150	2.939
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	0.001174	2.930
RNA Polymerase II Pre-transcription Events	R-HSA-674695	0.001306	2.884
PI3K/AKT Signaling in Cancer	R-HSA-2219528	0.001934	2.714
Apoptotic execution phase	R-HSA-75153	0.001996	2.700
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	0.002013	2.696
HSF1 activation	R-HSA-3371511	0.002255	2.647
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	0.002290	2.640
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	0.002456	2.610
RNA Polymerase II Transcription	R-HSA-73857	0.002620	2.582
Metabolism of RNA	R-HSA-8953854	0.002742	2.562
Signaling by NTRKs	R-HSA-166520	0.003227	2.491
Transcriptional Regulation by TP53	R-HSA-3700989	0.003332	2.477
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	0.003582	2.446
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	0.003751	2.426
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	0.003825	2.417
Signal Transduction	R-HSA-162582	0.003845	2.415
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	0.004298	2.367
Impaired BRCA2 binding to PALB2	R-HSA-9709603	0.004178	2.379
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	0.004532	2.344
Mitotic Telophase/Cytokinesis	R-HSA-68884	0.005343	2.272
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	0.005299	2.276
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	0.005299	2.276
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	0.005299	2.276
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	0.005299	2.276
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	0.005299	2.276
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	0.005342	2.272
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	0.005547	2.256
Signaling by NTRK1 (TRKA)	R-HSA-187037	0.005382	2.269
Cell Cycle	R-HSA-1640170	0.005104	2.292
Regulation of TP53 Activity	R-HSA-5633007	0.004702	2.328
HDMs demethylate histones	R-HSA-3214842	0.005939	2.226
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	0.005964	2.224
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	0.006574	2.182
RNA Polymerase II Transcription Termination	R-HSA-73856	0.006968	2.157
HATs acetylate histones	R-HSA-3214847	0.006926	2.160
Signaling by LTK	R-HSA-9842663	0.007221	2.141
AKT phosphorylates targets in the cytosol	R-HSA-198323	0.007221	2.141
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	0.007150	2.146
Cell Cycle Checkpoints	R-HSA-69620	0.007954	2.099
Transport of the SLBP independent Mature mRNA	R-HSA-159227	0.008825	2.054
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	0.008676	2.062
Inactivation of CDC42 and RAC1	R-HSA-428543	0.009043	2.044
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	0.010345	1.985
HIV elongation arrest and recovery	R-HSA-167287	0.010423	1.982
Pausing and recovery of HIV elongation	R-HSA-167290	0.010423	1.982
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	0.010087	1.996
G alpha (12/13) signalling events	R-HSA-416482	0.010326	1.986
PIP3 activates AKT signaling	R-HSA-1257604	0.010510	1.978
Intracellular signaling by second messengers	R-HSA-9006925	0.009746	2.011
Polo-like kinase mediated events	R-HSA-156711	0.011351	1.945
mRNA 3'-end processing	R-HSA-72187	0.011736	1.930
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	0.012333	1.909
Impaired BRCA2 binding to RAD51	R-HSA-9709570	0.012373	1.908
Epigenetic regulation of gene expression	R-HSA-212165	0.012655	1.898
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	0.012583	1.900
PKMTs methylate histone lysines	R-HSA-3214841	0.013432	1.872
Rap1 signalling	R-HSA-392517	0.014016	1.853
ESR-mediated signaling	R-HSA-8939211	0.014521	1.838
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	0.015663	1.805
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	0.016212	1.790
TGFBR3 expression	R-HSA-9839394	0.017418	1.759
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	0.017418	1.759
Sema4D in semaphorin signaling	R-HSA-400685	0.017418	1.759
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	0.018852	1.725
Diseases of Telomere Maintenance	R-HSA-9673013	0.018852	1.725
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	0.018852	1.725
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	0.018852	1.725
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	0.018852	1.725
NRAGE signals death through JNK	R-HSA-193648	0.018808	1.726
MITF-M-dependent gene expression	R-HSA-9856651	0.020025	1.698
Nuclear Envelope Breakdown	R-HSA-2980766	0.020994	1.678
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	0.020994	1.678
Cohesin Loading onto Chromatin	R-HSA-2470946	0.021511	1.667
Amplification of signal from the kinetochores	R-HSA-141424	0.022188	1.654
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	0.022188	1.654
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	0.022949	1.639
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	0.022949	1.639
Nuclear RNA decay	R-HSA-9930044	0.022949	1.639
Cardiogenesis	R-HSA-9733709	0.022949	1.639
Generic Transcription Pathway	R-HSA-212436	0.021959	1.658
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	0.023325	1.632
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	0.024096	1.618
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	0.024096	1.618
Resolution of D-Loop Structures	R-HSA-5693537	0.026377	1.579
Transcriptional activation of p53 responsive genes	R-HSA-69560	0.025537	1.593
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	0.025537	1.593
Mitotic Prophase	R-HSA-68875	0.027145	1.566
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	0.027329	1.563
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	0.027597	1.559
Signaling by ALK in cancer	R-HSA-9700206	0.027597	1.559
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	0.027775	1.556
Regulation of PTEN gene transcription	R-HSA-8943724	0.028691	1.542
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	0.030151	1.521
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	0.030151	1.521
NPAS4 regulates expression of target genes	R-HSA-9768919	0.030151	1.521
Estrogen-dependent gene expression	R-HSA-9018519	0.034183	1.466
Late Phase of HIV Life Cycle	R-HSA-162599	0.032426	1.489
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	0.034210	1.466
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	0.034286	1.465
Ephrin signaling	R-HSA-3928664	0.035106	1.455
PKA activation in glucagon signalling	R-HSA-164378	0.035106	1.455
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	0.035106	1.455
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	0.037185	1.430
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	0.037617	1.425
Oncogenic MAPK signaling	R-HSA-6802957	0.037864	1.422
Interactions of Tat with host cellular proteins	R-HSA-176034	0.039638	1.402
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	0.039804	1.400
EPH-Ephrin signaling	R-HSA-2682334	0.042333	1.373
CD209 (DC-SIGN) signaling	R-HSA-5621575	0.039804	1.400
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	0.042438	1.372
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	0.042438	1.372
Vpr-mediated nuclear import of PICs	R-HSA-180910	0.043692	1.360
Ovarian tumor domain proteases	R-HSA-5689896	0.043692	1.360
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	0.043692	1.360
MET activates RAP1 and RAC1	R-HSA-8875555	0.048415	1.315
PI3K/AKT activation	R-HSA-198203	0.048415	1.315
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	0.048933	1.310
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	0.048933	1.310
ATP-dependent chromatin remodelers	R-HSA-9932444	0.045962	1.338
SWI/SNF chromatin remodelers	R-HSA-9932451	0.045962	1.338
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	0.045788	1.339
Mitotic Spindle Checkpoint	R-HSA-69618	0.046586	1.332
Diseases of mitotic cell cycle	R-HSA-9675126	0.048159	1.317
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	0.048986	1.310
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	0.048986	1.310
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	0.044269	1.354
HIV Life Cycle	R-HSA-162587	0.048659	1.313
DCC mediated attractive signaling	R-HSA-418885	0.050438	1.297
Cell-extracellular matrix interactions	R-HSA-446353	0.050438	1.297
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	0.050617	1.296
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	0.052111	1.283
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	0.052111	1.283
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	0.052111	1.283
G2/M DNA damage checkpoint	R-HSA-69473	0.052127	1.283
Myogenesis	R-HSA-525793	0.052698	1.278
M Phase	R-HSA-68886	0.052900	1.277
Transcriptional Regulation by NPAS4	R-HSA-9634815	0.053056	1.275
Interaction between L1 and Ankyrins	R-HSA-445095	0.060023	1.222
IPs transport between nucleus and cytosol	R-HSA-1855170	0.054360	1.265
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	0.054687	1.262
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	0.054687	1.262
Transcription of the HIV genome	R-HSA-167172	0.058906	1.230
VEGFA-VEGFR2 Pathway	R-HSA-4420097	0.054430	1.264
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	0.059754	1.224
WNT5A-dependent internalization of FZD4	R-HSA-5099900	0.060078	1.221
Mitotic Prometaphase	R-HSA-68877	0.060367	1.219
HIV Transcription Elongation	R-HSA-167169	0.060802	1.216
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	0.060802	1.216
Interactions of Rev with host cellular proteins	R-HSA-177243	0.060802	1.216
Interactions of Vpr with host cellular proteins	R-HSA-176033	0.060802	1.216
Response of endothelial cells to shear stress	R-HSA-9860931	0.060844	1.216
Interleukin-12 signaling	R-HSA-9020591	0.060896	1.215
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	0.061048	1.214
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	0.063787	1.195
Signaling by PDGFR in disease	R-HSA-9671555	0.065691	1.182
Regulation of cortical dendrite branching	R-HSA-8985801	0.065892	1.181
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	0.065892	1.181
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	0.073344	1.135
Processing of Intronless Pre-mRNAs	R-HSA-77595	0.070691	1.151
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	0.070691	1.151
Notch-HLH transcription pathway	R-HSA-350054	0.075182	1.124
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	0.075909	1.120
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	0.072057	1.142
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	0.067970	1.168
Signaling by EGFR	R-HSA-177929	0.075574	1.122
NGF-stimulated transcription	R-HSA-9031628	0.072057	1.142
Cell Cycle, Mitotic	R-HSA-69278	0.070835	1.150
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	0.073344	1.135
Nuclear import of Rev protein	R-HSA-180746	0.068230	1.166
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	0.077386	1.111
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	0.081285	1.090
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	0.082555	1.083
Extra-nuclear estrogen signaling	R-HSA-9009391	0.082667	1.083
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	0.098794	1.005
Impaired BRCA2 translocation to the nucleus	R-HSA-9709275	0.187833	0.726
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	0.187833	0.726
Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)	R-HSA-9036092	0.187833	0.726
Defective SLC2A10 causes arterial tortuosity syndrome (ATS)	R-HSA-5619068	0.187833	0.726
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	0.187833	0.726
Impaired BRCA2 binding to SEM1 (DSS1)	R-HSA-9763198	0.187833	0.726
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	0.096333	1.016
Invadopodia formation	R-HSA-8941237	0.096333	1.016
Inhibition of TSC complex formation by PKB	R-HSA-165181	0.129878	0.886
PLCG1 events in ERBB2 signaling	R-HSA-1251932	0.129878	0.886
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	0.129878	0.886
GRB7 events in ERBB2 signaling	R-HSA-1306955	0.129878	0.886
PTEN Loss of Function in Cancer	R-HSA-5674404	0.268079	0.572
Intestinal infectious diseases	R-HSA-8942233	0.268079	0.572
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	0.268079	0.572
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	0.087781	1.057
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	0.087781	1.057
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	0.165617	0.781
IRS activation	R-HSA-74713	0.165617	0.781
Type I hemidesmosome assembly	R-HSA-446107	0.108581	0.964
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	0.108581	0.964
Signaling by MRAS-complex mutants	R-HSA-9660537	0.108581	0.964
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	0.108581	0.964
RUNX3 regulates NOTCH signaling	R-HSA-8941856	0.087824	1.056
WNT mediated activation of DVL	R-HSA-201688	0.131070	0.882
ALK mutants bind TKIs	R-HSA-9700645	0.131070	0.882
Nef Mediated CD8 Down-regulation	R-HSA-182218	0.202790	0.693
Signaling by MAPK mutants	R-HSA-9652817	0.202790	0.693
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	0.340401	0.468
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	0.340401	0.468
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	0.340401	0.468
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	0.340401	0.468
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)	R-HSA-5619049	0.340401	0.468
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	0.340401	0.468
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	0.340401	0.468
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	0.340401	0.468
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	0.340401	0.468
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	0.340401	0.468
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	0.340401	0.468
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	0.340401	0.468
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	0.340401	0.468
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	0.340401	0.468
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	0.103568	0.985
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	0.103568	0.985
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	0.155018	0.810
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	0.155018	0.810
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	0.120497	0.919
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	0.240766	0.618
FOXO-mediated transcription of cell death genes	R-HSA-9614657	0.094776	1.023
Regulation of localization of FOXO transcription factors	R-HSA-9614399	0.180195	0.744
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	0.108196	0.966
Deadenylation of mRNA	R-HSA-429947	0.096364	1.016
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	0.157553	0.803
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	0.206374	0.685
Signaling by GSK3beta mutants	R-HSA-5339716	0.206374	0.685
RUNX3 regulates WNT signaling	R-HSA-8951430	0.279023	0.554
Regulation of PTEN localization	R-HSA-8948747	0.279023	0.554
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	0.279023	0.554
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	0.279023	0.554
TRIF-mediated programmed cell death	R-HSA-2562578	0.279023	0.554
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	0.279023	0.554
SOS-mediated signalling	R-HSA-112412	0.279023	0.554
Disinhibition of SNARE formation	R-HSA-114516	0.279023	0.554
Axonal growth stimulation	R-HSA-209563	0.405581	0.392
Signaling by plasma membrane FGFR1 fusions	R-HSA-8853336	0.405581	0.392
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	0.405581	0.392
MET activates PTPN11	R-HSA-8865999	0.405581	0.392
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	0.405581	0.392
RUNX3 regulates p14-ARF	R-HSA-8951936	0.233336	0.632
SHC-related events triggered by IGF1R	R-HSA-2428933	0.233336	0.632
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	0.233336	0.632
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	0.233336	0.632
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	0.233336	0.632
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	0.233336	0.632
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	0.233336	0.632
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	0.198199	0.703
Regulation of NPAS4 mRNA translation	R-HSA-9768778	0.317135	0.499
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	0.260874	0.584
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	0.260874	0.584
Signaling by ERBB2 ECD mutants	R-HSA-9665348	0.219602	0.658
GAB1 signalosome	R-HSA-180292	0.219602	0.658
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	0.139778	0.855
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	0.106395	0.973
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	0.088797	1.052
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	0.176135	0.754
SHC1 events in ERBB2 signaling	R-HSA-1250196	0.176135	0.754
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	0.354758	0.450
MTF1 activates gene expression	R-HSA-5660489	0.464323	0.333
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	0.464323	0.333
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	0.464323	0.333
AKT-mediated inactivation of FOXO1A	R-HSA-211163	0.464323	0.333
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	0.464323	0.333
Defective LFNG causes SCDO3	R-HSA-5083630	0.464323	0.333
Defective CP causes aceruloplasminemia (ACERULOP)	R-HSA-5619060	0.464323	0.333
Downstream signal transduction	R-HSA-186763	0.191487	0.718
GPER1 signaling	R-HSA-9634597	0.134861	0.870
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	0.264028	0.578
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	0.178656	0.748
Erythropoietin activates RAS	R-HSA-9027284	0.316916	0.499
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	0.316916	0.499
Beta-catenin phosphorylation cascade	R-HSA-196299	0.316916	0.499
ERBB2 Regulates Cell Motility	R-HSA-6785631	0.316916	0.499
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	0.242510	0.615
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	0.261783	0.582
Formation of a pool of free 40S subunits	R-HSA-72689	0.093285	1.030
Defective GALNT12 causes CRCS1	R-HSA-5083636	0.345076	0.462
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	0.087436	1.058
Condensation of Prophase Chromosomes	R-HSA-2299718	0.204883	0.688
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	0.281392	0.551
Formation of the Early Elongation Complex	R-HSA-113418	0.281392	0.551
Nonsense-Mediated Decay (NMD)	R-HSA-927802	0.103183	0.986
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	0.103183	0.986
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	0.122291	0.913
Signaling by RAF1 mutants	R-HSA-9656223	0.251910	0.599
Degradation of GLI1 by the proteasome	R-HSA-5610780	0.251910	0.599
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	0.373126	0.428
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	0.427494	0.369
Activated NTRK3 signals through RAS	R-HSA-9034864	0.427494	0.369
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	0.427494	0.369
Signaling by APC mutants	R-HSA-4839744	0.427494	0.369
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	0.427494	0.369
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	0.427494	0.369
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	0.427494	0.369
G2 Phase	R-HSA-68911	0.517263	0.286
NOSIP mediated eNOS trafficking	R-HSA-203754	0.517263	0.286
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	0.517263	0.286
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	0.210218	0.677
Loss of Nlp from mitotic centrosomes	R-HSA-380259	0.210218	0.677
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	0.165899	0.780
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	0.292305	0.534
Interleukin receptor SHC signaling	R-HSA-912526	0.356472	0.448
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	0.096358	1.016
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	0.196785	0.706
PI3K events in ERBB2 signaling	R-HSA-1963642	0.400933	0.397
AURKA Activation by TPX2	R-HSA-8854518	0.246245	0.609
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	0.210906	0.676
Condensation of Prometaphase Chromosomes	R-HSA-2514853	0.462225	0.335
Activated NTRK2 signals through RAS	R-HSA-9026519	0.462225	0.335
ERKs are inactivated	R-HSA-202670	0.462225	0.335
Regulation of endogenous retroelements	R-HSA-9842860	0.205503	0.687
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	0.236946	0.625
Meiotic synapsis	R-HSA-1221632	0.304559	0.516
RNA Polymerase III Transcription Termination	R-HSA-73980	0.428381	0.368
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	0.332329	0.478
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	0.332329	0.478
Signaling downstream of RAS mutants	R-HSA-9649948	0.332329	0.478
mRNA Splicing - Minor Pathway	R-HSA-72165	0.332329	0.478
Translation initiation complex formation	R-HSA-72649	0.319660	0.495
HDACs deacetylate histones	R-HSA-3214815	0.334898	0.475
Ribosomal scanning and start codon recognition	R-HSA-72702	0.350245	0.456
Striated Muscle Contraction	R-HSA-390522	0.402567	0.395
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	0.495686	0.305
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	0.495686	0.305
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	0.495686	0.305
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	0.495686	0.305
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	0.564974	0.248
Cam-PDE 1 activation	R-HSA-111957	0.564974	0.248
PTK6 Regulates Cell Cycle	R-HSA-8849470	0.564974	0.248
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	0.564974	0.248
PDE3B signalling	R-HSA-165160	0.564974	0.248
PKB-mediated events	R-HSA-109703	0.564974	0.248
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	0.564974	0.248
Defective CSF2RA causes SMDP4	R-HSA-5688890	0.564974	0.248
Defective CSF2RB causes SMDP5	R-HSA-5688849	0.564974	0.248
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	0.564974	0.248
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	0.337179	0.472
Viral mRNA Translation	R-HSA-192823	0.303146	0.518
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	0.422803	0.374
Centrosome maturation	R-HSA-380287	0.364299	0.439
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	0.419298	0.377
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	0.412217	0.385
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	0.527789	0.278
Adenylate cyclase activating pathway	R-HSA-170660	0.527789	0.278
PRC2 methylates histones and DNA	R-HSA-212300	0.462840	0.335
TNFR1-induced proapoptotic signaling	R-HSA-5357786	0.507608	0.294
Signaling by Erythropoietin	R-HSA-9006335	0.493533	0.307
Signaling by ERBB2 KD Mutants	R-HSA-9664565	0.493533	0.307
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	0.493533	0.307
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	0.428219	0.368
Signaling by ERBB2 in Cancer	R-HSA-1227990	0.515297	0.288
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	0.558474	0.253
Retrograde neurotrophin signalling	R-HSA-177504	0.558474	0.253
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	0.558474	0.253
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	0.557107	0.254
FGFR2 alternative splicing	R-HSA-6803529	0.557107	0.254
Spry regulation of FGF signaling	R-HSA-1295596	0.587710	0.231
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	0.587710	0.231
Sema3A PAK dependent Axon repulsion	R-HSA-399954	0.587710	0.231
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	0.587710	0.231
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	0.587710	0.231
Adenylate cyclase inhibitory pathway	R-HSA-170670	0.587710	0.231
SHC1 events in EGFR signaling	R-HSA-180336	0.587710	0.231
Regulation of PTEN mRNA translation	R-HSA-8943723	0.580705	0.236
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	0.576625	0.239
Degradation of GLI2 by the proteasome	R-HSA-5610783	0.576625	0.239
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	0.577359	0.239
PTEN Regulation	R-HSA-6807070	0.275996	0.559
FOXO-mediated transcription	R-HSA-9614085	0.360279	0.443
RNA Polymerase III Transcription	R-HSA-74158	0.292305	0.534
Integrin signaling	R-HSA-354192	0.223611	0.651
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	0.507608	0.294
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	0.507608	0.294
EGFR downregulation	R-HSA-182971	0.191487	0.718
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	0.386996	0.412
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	0.386996	0.412
Signaling by EGFRvIII in Cancer	R-HSA-5637812	0.400933	0.397
Constitutive Signaling by EGFRvIII	R-HSA-5637810	0.400933	0.397
Processing of DNA double-strand break ends	R-HSA-5693607	0.086992	1.061
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	0.168905	0.772
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	0.094776	1.023
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	0.386996	0.412
EPHB-mediated forward signaling	R-HSA-3928662	0.097734	1.010
Formation of definitive endoderm	R-HSA-9823730	0.264028	0.578
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	0.165968	0.780
RNA Polymerase III Transcription Initiation	R-HSA-76046	0.515297	0.288
MET promotes cell motility	R-HSA-8875878	0.328149	0.484
Hedgehog 'off' state	R-HSA-5610787	0.123860	0.907
VxPx cargo-targeting to cilium	R-HSA-5620916	0.264028	0.578
Ribosome-associated quality control	R-HSA-9948299	0.545923	0.263
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	0.282346	0.549
Generation of second messenger molecules	R-HSA-202433	0.221518	0.655
Homology Directed Repair	R-HSA-5693538	0.220432	0.657
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	0.095247	1.021
Aggrephagy	R-HSA-9646399	0.540023	0.268
DNA Double-Strand Break Repair	R-HSA-5693532	0.329753	0.482
Signal attenuation	R-HSA-74749	0.155018	0.810
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	0.176135	0.754
NoRC negatively regulates rRNA expression	R-HSA-427413	0.310446	0.508
Clathrin-mediated endocytosis	R-HSA-8856828	0.242507	0.615
Platelet Aggregation (Plug Formation)	R-HSA-76009	0.473444	0.325
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	0.171400	0.766
Signaling by ERBB2	R-HSA-1227986	0.280244	0.552
Frs2-mediated activation	R-HSA-170968	0.260874	0.584
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	0.423834	0.373
EGFR Transactivation by Gastrin	R-HSA-2179392	0.391616	0.407
Glucagon signaling in metabolic regulation	R-HSA-163359	0.240296	0.619
MAP2K and MAPK activation	R-HSA-5674135	0.251910	0.599
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	0.312090	0.506
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	0.363135	0.440
DAP12 signaling	R-HSA-2424491	0.176135	0.754
IGF1R signaling cascade	R-HSA-2428924	0.136363	0.865
TRAF3-dependent IRF activation pathway	R-HSA-918233	0.373126	0.428
DNA Double Strand Break Response	R-HSA-5693606	0.258715	0.587
Meiosis	R-HSA-1500620	0.266357	0.575
Downregulation of ERBB4 signaling	R-HSA-1253288	0.317135	0.499
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	0.354758	0.450
Regulation of TP53 Degradation	R-HSA-6804757	0.165217	0.782
Regulation of CDH11 function	R-HSA-9762292	0.391616	0.407
Peptide chain elongation	R-HSA-156902	0.141507	0.849
Synthesis of PIPs at the ER membrane	R-HSA-1483248	0.427494	0.369
Transcriptional regulation by small RNAs	R-HSA-5578749	0.216801	0.664
VEGFR2 mediated vascular permeability	R-HSA-5218920	0.382784	0.417
Insulin receptor signalling cascade	R-HSA-74751	0.473952	0.324
G-protein beta:gamma signalling	R-HSA-397795	0.577774	0.238
HDR through Homologous Recombination (HRR)	R-HSA-5685942	0.258715	0.587
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	0.323755	0.490
Downstream signaling of activated FGFR3	R-HSA-5654708	0.493533	0.307
Downstream signaling of activated FGFR4	R-HSA-5654716	0.515297	0.288
Signaling by FGFR2	R-HSA-5654738	0.564811	0.248
Signaling by FGFR4	R-HSA-5654743	0.437465	0.359
Signaling by RAS mutants	R-HSA-6802949	0.332329	0.478
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	0.443207	0.353
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	0.536617	0.270
Netrin-1 signaling	R-HSA-373752	0.097734	1.010
G1 Phase	R-HSA-69236	0.455525	0.341
Cyclin D associated events in G1	R-HSA-69231	0.455525	0.341
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	0.129878	0.886
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	0.157553	0.803
Adrenoceptors	R-HSA-390696	0.317135	0.499
PKA activation	R-HSA-163615	0.219602	0.658
p75NTR regulates axonogenesis	R-HSA-193697	0.354758	0.450
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	0.354758	0.450
Regulation of gap junction activity	R-HSA-191650	0.464323	0.333
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	0.517263	0.286
Trafficking of AMPA receptors	R-HSA-399719	0.341591	0.466
Role of second messengers in netrin-1 signaling	R-HSA-418890	0.495686	0.305
Separation of Sister Chromatids	R-HSA-2467813	0.268221	0.572
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	0.419298	0.377
Membrane binding and targetting of GAG proteins	R-HSA-174490	0.527789	0.278
Formation of axial mesoderm	R-HSA-9796292	0.527789	0.278
PCP/CE pathway	R-HSA-4086400	0.405397	0.392
IRS-related events triggered by IGF1R	R-HSA-2428928	0.427731	0.369
Cyclin E associated events during G1/S transition	R-HSA-69202	0.423315	0.373
DARPP-32 events	R-HSA-180024	0.493533	0.307
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	0.473444	0.325
Signaling by FGFR3	R-HSA-5654741	0.473444	0.325
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	0.442909	0.354
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	0.145410	0.837
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	0.555970	0.255
G1/S DNA Damage Checkpoints	R-HSA-69615	0.210218	0.677
Signaling by FLT3 fusion proteins	R-HSA-9703465	0.242510	0.615
Activation of HOX genes during differentiation	R-HSA-5619507	0.546377	0.263
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	0.546377	0.263
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	0.108581	0.964
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	0.133401	0.875
Signaling by FGFR1 in disease	R-HSA-5655302	0.143369	0.844
PKA-mediated phosphorylation of CREB	R-HSA-111931	0.286840	0.542
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	0.261783	0.582
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	0.265464	0.576
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	0.561475	0.251
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	0.561475	0.251
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	0.561475	0.251
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	0.561475	0.251
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	0.419298	0.377
Signaling by PDGF	R-HSA-186797	0.443207	0.353
Signaling by FGFR1	R-HSA-5654736	0.498264	0.303
Transcriptional regulation by RUNX3	R-HSA-8878159	0.104882	0.979
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	0.178640	0.748
Meiotic recombination	R-HSA-912446	0.415740	0.381
Regulation of TP53 Expression and Degradation	R-HSA-6806003	0.206835	0.684
Prolonged ERK activation events	R-HSA-169893	0.345076	0.462
Post-transcriptional silencing by small RNAs	R-HSA-426496	0.165617	0.781
Calcineurin activates NFAT	R-HSA-2025928	0.131070	0.882
Negative feedback regulation of MAPK pathway	R-HSA-5674499	0.202790	0.693
Disorders of Developmental Biology	R-HSA-9675151	0.177480	0.751
Axonal growth inhibition (RHOA activation)	R-HSA-193634	0.317135	0.499
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	0.219602	0.658
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	0.176135	0.754
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	0.191812	0.717
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	0.345076	0.462
Killing mechanisms	R-HSA-9664420	0.345076	0.462
Eukaryotic Translation Initiation	R-HSA-72613	0.091818	1.037
Formation of the posterior neural plate	R-HSA-9832991	0.427494	0.369
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	0.152069	0.818
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	0.462225	0.335
rRNA processing in the nucleus and cytosol	R-HSA-8868773	0.141332	0.850
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	0.422803	0.374
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	0.527789	0.278
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	0.507608	0.294
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	0.558474	0.253
IRS-mediated signalling	R-HSA-112399	0.514367	0.289
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	0.543121	0.265
TCF dependent signaling in response to WNT	R-HSA-201681	0.359986	0.444
Oxidative Stress Induced Senescence	R-HSA-2559580	0.205503	0.687
Signaling by Hedgehog	R-HSA-5358351	0.267151	0.573
TNF signaling	R-HSA-75893	0.227097	0.644
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	0.104704	0.980
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	0.382277	0.418
p53-Dependent G1 DNA Damage Response	R-HSA-69563	0.382277	0.418
Regulation of TNFR1 signaling	R-HSA-5357905	0.491191	0.309
Neurexins and neuroligins	R-HSA-6794361	0.289621	0.538
Signaling by Nuclear Receptors	R-HSA-9006931	0.180653	0.743
Signaling by WNT	R-HSA-195721	0.391251	0.408
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	0.154763	0.810
Cap-dependent Translation Initiation	R-HSA-72737	0.091818	1.037
Beta-catenin independent WNT signaling	R-HSA-3858494	0.425537	0.371
Protein-protein interactions at synapses	R-HSA-6794362	0.376088	0.425
Mitotic Metaphase and Anaphase	R-HSA-2555396	0.274352	0.562
Signaling by VEGF	R-HSA-194138	0.100869	0.996
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	0.202790	0.693
Regulation of CDH19 Expression and Function	R-HSA-9764302	0.202790	0.693
Nef Mediated CD4 Down-regulation	R-HSA-167590	0.279023	0.554
Disorders of Nervous System Development	R-HSA-9697154	0.233336	0.632
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	0.233336	0.632
Pervasive developmental disorders	R-HSA-9005895	0.233336	0.632
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	0.288794	0.539
Lipophagy	R-HSA-9613354	0.354758	0.450
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	0.464323	0.333
FGFR1 mutant receptor activation	R-HSA-1839124	0.223611	0.651
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	0.517263	0.286
Eukaryotic Translation Termination	R-HSA-72764	0.220505	0.657
Negative regulation of the PI3K/AKT network	R-HSA-199418	0.257433	0.589
Cellular Senescence	R-HSA-2559583	0.260554	0.584
Deadenylation-dependent mRNA decay	R-HSA-429914	0.396687	0.402
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	0.558474	0.253
Signalling to ERKs	R-HSA-187687	0.442909	0.354
Mitotic Anaphase	R-HSA-68882	0.267210	0.573
Negative regulation of MAPK pathway	R-HSA-5675221	0.251910	0.599
MTOR signalling	R-HSA-165159	0.154864	0.810
G-protein mediated events	R-HSA-112040	0.519250	0.285
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	0.165617	0.781
ROBO receptors bind AKAP5	R-HSA-9010642	0.108581	0.964
Regulation of MECP2 expression and activity	R-HSA-9022692	0.116412	0.934
Vasopressin-like receptors	R-HSA-388479	0.464323	0.333
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	0.223611	0.651
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	0.240296	0.619
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	0.400933	0.397
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	0.382784	0.417
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	0.491191	0.309
Formation of the ureteric bud	R-HSA-9830674	0.580705	0.236
Signaling by NOTCH1 in Cancer	R-HSA-2644603	0.561475	0.251
Neurodegenerative Diseases	R-HSA-8863678	0.096364	1.016
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	0.096364	1.016
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	0.316916	0.499
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	0.223611	0.651
Cellular responses to mechanical stimuli	R-HSA-9855142	0.114603	0.941
Gastrulation	R-HSA-9758941	0.568222	0.245
Developmental Biology	R-HSA-1266738	0.357292	0.447
Regulation of CDH11 Expression and Function	R-HSA-9759475	0.301272	0.521
Specification of the neural plate border	R-HSA-9834899	0.241581	0.617
Mitotic G2-G2/M phases	R-HSA-453274	0.403754	0.394
Deubiquitination	R-HSA-5688426	0.421418	0.375
Membrane Trafficking	R-HSA-199991	0.400613	0.397
Ub-specific processing proteases	R-HSA-5689880	0.527722	0.278
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	0.458621	0.339
G2/M Transition	R-HSA-69275	0.470535	0.327
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	0.551231	0.259
HIV Infection	R-HSA-162906	0.280858	0.552
G0 and Early G1	R-HSA-1538133	0.105556	0.977
Hedgehog 'on' state	R-HSA-5632684	0.437845	0.359
Signaling by NOTCH1	R-HSA-1980143	0.509554	0.293
Semaphorin interactions	R-HSA-373755	0.127627	0.894
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	0.474630	0.324
SDK interactions	R-HSA-373756	0.187833	0.726
ARL13B-mediated ciliary trafficking of INPP5E	R-HSA-5624958	0.268079	0.572
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	0.268079	0.572
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	0.165617	0.781
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	0.103568	0.985
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	0.405581	0.392
Activation of BIM and translocation to mitochondria	R-HSA-111446	0.405581	0.392
MET interacts with TNS proteins	R-HSA-8875513	0.405581	0.392
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	0.133401	0.875
Reversible hydration of carbon dioxide	R-HSA-1475029	0.260874	0.584
Depolymerization of the Nuclear Lamina	R-HSA-4419969	0.219602	0.658
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	0.464323	0.333
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	0.178656	0.748
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	0.391616	0.407
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	0.391616	0.407
snRNP Assembly	R-HSA-191859	0.165968	0.780
Metabolism of non-coding RNA	R-HSA-194441	0.165968	0.780
Reproduction	R-HSA-1474165	0.090043	1.046
Reelin signalling pathway	R-HSA-8866376	0.517263	0.286
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	0.462225	0.335
Signaling by AXIN mutants	R-HSA-4839735	0.462225	0.335
Signaling by AMER1 mutants	R-HSA-4839748	0.462225	0.335
Viral Messenger RNA Synthesis	R-HSA-168325	0.294055	0.532
Regulation of TP53 Activity through Methylation	R-HSA-6804760	0.428381	0.368
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	0.428381	0.368
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	0.291134	0.536
VLDLR internalisation and degradation	R-HSA-8866427	0.495686	0.305
NGF-independant TRKA activation	R-HSA-187024	0.564974	0.248
Synthesis of PS	R-HSA-1483101	0.564974	0.248
Phosphorylation of Emi1	R-HSA-176417	0.564974	0.248
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	0.381165	0.419
PI3K Cascade	R-HSA-109704	0.399013	0.399
Phase 0 - rapid depolarisation	R-HSA-5576892	0.471367	0.327
Cell junction organization	R-HSA-446728	0.257049	0.590
Evasion by RSV of host interferon responses	R-HSA-9833109	0.536617	0.270
RAF/MAP kinase cascade	R-HSA-5673001	0.394062	0.404
Regulation of CDH1 Expression and Function	R-HSA-9764265	0.438353	0.358
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	0.438353	0.358
Diseases of programmed cell death	R-HSA-9645723	0.553654	0.257
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	0.308033	0.511
Cell-Cell communication	R-HSA-1500931	0.132544	0.878
Signaling by ERBB4	R-HSA-1236394	0.481129	0.318
Heme signaling	R-HSA-9707616	0.198721	0.702
Aquaporin-mediated transport	R-HSA-445717	0.294055	0.532
GPVI-mediated activation cascade	R-HSA-114604	0.462840	0.335
Signaling by TGFBR3	R-HSA-9839373	0.115475	0.938
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	0.389087	0.410
Signaling by FGFR in disease	R-HSA-1226099	0.350700	0.455
PLC beta mediated events	R-HSA-112043	0.427731	0.369
Signaling by FGFR4 in disease	R-HSA-5655291	0.558474	0.253
TCR signaling	R-HSA-202403	0.392807	0.406
G alpha (z) signalling events	R-HSA-418597	0.481995	0.317
rRNA processing	R-HSA-72312	0.464794	0.333
MAPK1/MAPK3 signaling	R-HSA-5684996	0.444760	0.352
Ca-dependent events	R-HSA-111996	0.267554	0.573
Eukaryotic Translation Elongation	R-HSA-156842	0.183277	0.737
Macroautophagy	R-HSA-1632852	0.576420	0.239
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	0.106395	0.973
Maternal to zygotic transition (MZT)	R-HSA-9816359	0.562399	0.250
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	0.131070	0.882
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	0.155018	0.810
ERK/MAPK targets	R-HSA-198753	0.286840	0.542
tRNA processing in the nucleus	R-HSA-6784531	0.198721	0.702
Rab regulation of trafficking	R-HSA-9007101	0.211855	0.674
TRP channels	R-HSA-3295583	0.426037	0.371
MAPK family signaling cascades	R-HSA-5683057	0.235352	0.628
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	0.253210	0.597
DAP12 interactions	R-HSA-2172127	0.455525	0.341
Oncogene Induced Senescence	R-HSA-2559585	0.442909	0.354
Cellular responses to stress	R-HSA-2262752	0.438059	0.358
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	0.281392	0.551
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	0.382252	0.418
Cellular responses to stimuli	R-HSA-8953897	0.307893	0.512
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	0.322157	0.492
Signaling by PTK6	R-HSA-8848021	0.322157	0.492
Host Interactions of HIV factors	R-HSA-162909	0.467238	0.330
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	0.202790	0.693
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	0.354758	0.450
Muscarinic acetylcholine receptors	R-HSA-390648	0.517263	0.286
Release of Hh-Np from the secreting cell	R-HSA-5362798	0.564974	0.248
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	0.557107	0.254
Regulation of CDH1 Gene Transcription	R-HSA-9764560	0.195059	0.710
Cellular response to starvation	R-HSA-9711097	0.560493	0.251
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	0.136080	0.866
Calmodulin induced events	R-HSA-111933	0.292305	0.534
Signaling by TGFB family members	R-HSA-9006936	0.174159	0.759
Nephrin family interactions	R-HSA-373753	0.122486	0.912
Transcriptional Regulation by VENTX	R-HSA-8853884	0.558513	0.253
PI Metabolism	R-HSA-1483255	0.292330	0.534
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	0.412217	0.385
RUNX2 regulates bone development	R-HSA-8941326	0.165217	0.782
mTORC1-mediated signalling	R-HSA-166208	0.333156	0.477
CaM pathway	R-HSA-111997	0.292305	0.534
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	0.558474	0.253
MAPK6/MAPK4 signaling	R-HSA-5687128	0.500888	0.300
Signaling by TGF-beta Receptor Complex	R-HSA-170834	0.162791	0.788
Death Receptor Signaling	R-HSA-73887	0.095247	1.021
Signaling by NTRK2 (TRKB)	R-HSA-9006115	0.261783	0.582
Co-stimulation by CD28	R-HSA-389356	0.365564	0.437
TBC/RABGAPs	R-HSA-8854214	0.283451	0.548
Influenza Viral RNA Transcription and Replication	R-HSA-168273	0.143425	0.843
Uptake and function of anthrax toxins	R-HSA-5210891	0.400933	0.397
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	0.523589	0.281
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	0.456942	0.340
MAP kinase activation	R-HSA-450294	0.294055	0.532
Breakdown of the nuclear lamina	R-HSA-352238	0.268079	0.572
DSCAM interactions	R-HSA-376172	0.340401	0.468
Synthesis of PI	R-HSA-1483226	0.180195	0.744
Formation of the anterior neural plate	R-HSA-9823739	0.138525	0.858
CASP5-mediated substrate cleavage	R-HSA-9960525	0.405581	0.392
Signaling by ALK	R-HSA-201556	0.111582	0.952
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	0.288794	0.539
GP1b-IX-V activation signalling	R-HSA-430116	0.354758	0.450
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	0.354758	0.450
Sensory perception of sour taste	R-HSA-9729555	0.464323	0.333
Dissolution of Fibrin Clot	R-HSA-75205	0.427494	0.369
Biosynthesis of DPAn-3-derived 13-series resolvins	R-HSA-9026403	0.517263	0.286
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	0.382252	0.418
Signalling to p38 via RIT and RIN	R-HSA-187706	0.564974	0.248
CD28 dependent PI3K/Akt signaling	R-HSA-389357	0.448850	0.348
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	0.507608	0.294
Transcriptional regulation of granulopoiesis	R-HSA-9616222	0.443207	0.353
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	0.491191	0.309
Signaling by NOTCH3	R-HSA-9012852	0.481995	0.317
Interleukin-2 family signaling	R-HSA-451927	0.540023	0.268
DAG and IP3 signaling	R-HSA-1489509	0.473444	0.325
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	0.321359	0.493
Signaling by NTRK3 (TRKC)	R-HSA-9034015	0.532727	0.273
Interleukin-17 signaling	R-HSA-448424	0.423315	0.373
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	0.301272	0.521
Glycolysis	R-HSA-70171	0.271069	0.567
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	0.131070	0.882
Kidney development	R-HSA-9830369	0.379681	0.421
Protein hydroxylation	R-HSA-9629569	0.481800	0.317
Signal regulatory protein family interactions	R-HSA-391160	0.558474	0.253
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	0.361908	0.441
Transcriptional regulation by RUNX2	R-HSA-8878166	0.518270	0.285
Non-canonical inflammasome activation	R-HSA-9686114	0.558474	0.253
G2/M Checkpoints	R-HSA-69481	0.313507	0.504
Regulation of NFE2L2 gene expression	R-HSA-9818749	0.240766	0.618
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	0.240766	0.618
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	0.170100	0.769
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	0.316916	0.499
Suppression of apoptosis	R-HSA-9635465	0.427494	0.369
Transcriptional Regulation by MECP2	R-HSA-8986944	0.247462	0.606
Selenocysteine synthesis	R-HSA-2408557	0.281635	0.550
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	0.557107	0.254
Kinesins	R-HSA-983189	0.561475	0.251
MITF-M-regulated melanocyte development	R-HSA-9730414	0.141442	0.849
RMTs methylate histone arginines	R-HSA-3214858	0.455525	0.341
Inositol phosphate metabolism	R-HSA-1483249	0.314087	0.503
OAS antiviral response	R-HSA-8983711	0.233336	0.632
Diseases of DNA repair	R-HSA-9675135	0.115475	0.938
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	0.563124	0.249
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	0.382252	0.418
AKT phosphorylates targets in the nucleus	R-HSA-198693	0.131070	0.882
MECP2 regulates transcription factors	R-HSA-9022707	0.279023	0.554
Phase 3 - rapid repolarisation	R-HSA-5576890	0.279023	0.554
CASP4-mediated substrate cleavage	R-HSA-9960519	0.405581	0.392
Interleukin-18 signaling	R-HSA-9012546	0.317135	0.499
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	0.132315	0.878
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	0.354758	0.450
Dopamine receptors	R-HSA-390651	0.464323	0.333
Release of apoptotic factors from the mitochondria	R-HSA-111457	0.564974	0.248
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	0.314073	0.503
ISG15 antiviral mechanism	R-HSA-1169408	0.364299	0.439
FLT3 signaling in disease	R-HSA-9682385	0.462840	0.335
Zygotic genome activation (ZGA)	R-HSA-9819196	0.137601	0.861
Glucose metabolism	R-HSA-70326	0.389864	0.409
HDL assembly	R-HSA-8963896	0.288794	0.539
Maturation of nucleoprotein	R-HSA-9683610	0.527789	0.278
Protein methylation	R-HSA-8876725	0.587710	0.231
Stimuli-sensing channels	R-HSA-2672351	0.370010	0.432
Tie2 Signaling	R-HSA-210993	0.428381	0.368
SARS-CoV-1-host interactions	R-HSA-9692914	0.569890	0.244
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	0.317135	0.499
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	0.427494	0.369
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	0.564974	0.248
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	0.564974	0.248
LDL clearance	R-HSA-8964038	0.557107	0.254
Nephron development	R-HSA-9831926	0.219602	0.658
Gene Silencing by RNA	R-HSA-211000	0.467355	0.330
Influenza Infection	R-HSA-168255	0.190585	0.720
NS1 Mediated Effects on Host Pathways	R-HSA-168276	0.111582	0.952
Apoptosis	R-HSA-109581	0.505502	0.296
XBP1(S) activates chaperone genes	R-HSA-381038	0.126415	0.898
p75 NTR receptor-mediated signalling	R-HSA-193704	0.179286	0.746
IRE1alpha activates chaperones	R-HSA-381070	0.174479	0.758
Interleukin-7 signaling	R-HSA-1266695	0.402990	0.395
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	0.507608	0.294
Signaling by Leptin	R-HSA-2586552	0.391616	0.407
Interleukin-37 signaling	R-HSA-9008059	0.515297	0.288
Growth hormone receptor signaling	R-HSA-982772	0.580705	0.236
Interleukin-12 family signaling	R-HSA-447115	0.133842	0.873
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	0.085954	1.066
Adherens junctions interactions	R-HSA-418990	0.588360	0.230
Developmental Lineages of the Mammary Gland	R-HSA-9924644	0.591376	0.228
Pre-NOTCH Transcription and Translation	R-HSA-1912408	0.591747	0.228
RNA Polymerase I Transcription Initiation	R-HSA-73762	0.594336	0.226
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	0.603491	0.219
Plasma lipoprotein assembly	R-HSA-8963898	0.603491	0.219
Cytoprotection by HMOX1	R-HSA-9707564	0.604446	0.219
Ca2+ pathway	R-HSA-4086398	0.605163	0.218
rRNA modification in the nucleus and cytosol	R-HSA-6790901	0.606410	0.217
PTK6 promotes HIF1A stabilization	R-HSA-8857538	0.607972	0.216
Erythropoietin activates STAT5	R-HSA-9027283	0.607972	0.216
Autointegration results in viral DNA circles	R-HSA-177539	0.607972	0.216
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	0.607972	0.216
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	0.607972	0.216
Integration of viral DNA into host genomic DNA	R-HSA-175567	0.607972	0.216
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	0.607972	0.216
NADPH regeneration	R-HSA-389542	0.607972	0.216
Signaling by LTK in cancer	R-HSA-9842640	0.607972	0.216
Lipid particle organization	R-HSA-8964572	0.607972	0.216
Leukotriene receptors	R-HSA-391906	0.607972	0.216
Golgi Associated Vesicle Biogenesis	R-HSA-432722	0.608428	0.216
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	0.608428	0.216
Signaling by SCF-KIT	R-HSA-1433557	0.611627	0.214
Cell-cell junction organization	R-HSA-421270	0.615229	0.211
Phosphorylation of the APC/C	R-HSA-176412	0.615482	0.211
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	0.615482	0.211
Defective GALNT3 causes HFTC	R-HSA-5083625	0.615482	0.211
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	0.615482	0.211
Regulation of BACH1 activity	R-HSA-9708530	0.615482	0.211
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	0.615482	0.211
Induction of Cell-Cell Fusion	R-HSA-9733458	0.615482	0.211
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	0.615482	0.211
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	0.615482	0.211
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	0.615482	0.211
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	0.616173	0.210
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	0.616764	0.210
RAF activation	R-HSA-5673000	0.616764	0.210
NOD1/2 Signaling Pathway	R-HSA-168638	0.616764	0.210
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	0.616764	0.210
Formation of the nephric duct	R-HSA-9830364	0.625441	0.204
Autophagy	R-HSA-9612973	0.634660	0.197
Mitotic G1 phase and G1/S transition	R-HSA-453279	0.634818	0.197
Downstream signaling of activated FGFR2	R-HSA-5654696	0.635393	0.197
Downstream signaling of activated FGFR1	R-HSA-5654687	0.635393	0.197
GRB2 events in ERBB2 signaling	R-HSA-1963640	0.641795	0.193
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	0.641795	0.193
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	0.641795	0.193
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	0.641795	0.193
Acetylcholine regulates insulin secretion	R-HSA-399997	0.641795	0.193
Phase 2 - plateau phase	R-HSA-5576893	0.641795	0.193
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	0.641795	0.193
Nucleosome assembly	R-HSA-774815	0.644883	0.191
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	0.644883	0.191
Class I MHC mediated antigen processing & presentation	R-HSA-983169	0.645455	0.190
Signaling by EGFR in Cancer	R-HSA-1643713	0.646542	0.189
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	0.646542	0.189
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	0.646542	0.189
Metalloprotease DUBs	R-HSA-5689901	0.646542	0.189
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	0.646542	0.189
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	0.646542	0.189
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	0.646542	0.189
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	0.646723	0.189
MET activates PI3K/AKT signaling	R-HSA-8851907	0.646723	0.189
NOSTRIN mediated eNOS trafficking	R-HSA-203641	0.646723	0.189
Netrin mediated repulsion signals	R-HSA-418886	0.646723	0.189
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	0.646723	0.189
IFNG signaling activates MAPKs	R-HSA-9732724	0.646723	0.189
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	0.646723	0.189
PTK6 Expression	R-HSA-8849473	0.646723	0.189
Activated NTRK2 signals through CDK5	R-HSA-9032845	0.646723	0.189
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	0.646723	0.189
Activated NTRK3 signals through PI3K	R-HSA-9603381	0.646723	0.189
VLDL clearance	R-HSA-8964046	0.646723	0.189
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	0.646723	0.189
Activation of TRKA receptors	R-HSA-187015	0.646723	0.189
Displacement of DNA glycosylase by APEX1	R-HSA-110357	0.646723	0.189
Adipogenesis	R-HSA-9843745	0.664980	0.177
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	0.666665	0.176
Elevation of cytosolic Ca2+ levels	R-HSA-139853	0.666665	0.176
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	0.666665	0.176
Regulation of NPAS4 gene expression	R-HSA-9768759	0.666665	0.176
RNA Polymerase I Transcription Termination	R-HSA-73863	0.666784	0.176
EPHA-mediated growth cone collapse	R-HSA-3928663	0.666784	0.176
Degradation of DVL	R-HSA-4641258	0.670848	0.173
Circadian clock	R-HSA-9909396	0.674483	0.171
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	0.676294	0.170
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	0.678829	0.168
EGFR interacts with phospholipase C-gamma	R-HSA-212718	0.681645	0.166
phospho-PLA2 pathway	R-HSA-111995	0.681645	0.166
MET receptor recycling	R-HSA-8875656	0.681645	0.166
Activated NTRK2 signals through PI3K	R-HSA-9028335	0.681645	0.166
Sodium/Proton exchangers	R-HSA-425986	0.681645	0.166
Regulation by c-FLIP	R-HSA-3371378	0.681645	0.166
FGFR1b ligand binding and activation	R-HSA-190370	0.681645	0.166
Co-stimulation by ICOS	R-HSA-9927354	0.681645	0.166
Dimerization of procaspase-8	R-HSA-69416	0.681645	0.166
Alpha-defensins	R-HSA-1462054	0.681645	0.166
G alpha (s) signalling events	R-HSA-418555	0.685976	0.164
Negative regulation of FGFR3 signaling	R-HSA-5654732	0.686166	0.164
Activation of AMPK downstream of NMDARs	R-HSA-9619483	0.686166	0.164
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	0.688970	0.162
Synaptic adhesion-like molecules	R-HSA-8849932	0.690121	0.161
Chaperone Mediated Autophagy	R-HSA-9613829	0.690121	0.161
Platelet sensitization by LDL	R-HSA-432142	0.690121	0.161
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	0.690121	0.161
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	0.690844	0.161
Regulation of PD-L1(CD274) expression	R-HSA-9909648	0.694128	0.159
Signaling by MET	R-HSA-6806834	0.694447	0.158
Signaling by FGFR	R-HSA-190236	0.695820	0.158
MyD88 cascade initiated on plasma membrane	R-HSA-975871	0.695820	0.158
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	0.695820	0.158
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	0.695820	0.158
Muscle contraction	R-HSA-397014	0.697010	0.157
L1CAM interactions	R-HSA-373760	0.698573	0.156
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	0.700887	0.154
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	0.702106	0.154
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	0.702106	0.154
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	0.703851	0.153
Negative regulation of FGFR4 signaling	R-HSA-5654733	0.704692	0.152
DNA methylation	R-HSA-5334118	0.704692	0.152
Late endosomal microautophagy	R-HSA-9615710	0.704692	0.152
Glucagon-type ligand receptors	R-HSA-420092	0.704692	0.152
DNA Damage Bypass	R-HSA-73893	0.705799	0.151
MyD88 dependent cascade initiated on endosome	R-HSA-975155	0.712012	0.148
PI-3K cascade:FGFR3	R-HSA-5654710	0.712198	0.147
IKK complex recruitment mediated by RIP1	R-HSA-937041	0.712198	0.147
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	0.712198	0.147
Regulation of signaling by CBL	R-HSA-912631	0.712198	0.147
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	0.712198	0.147
Signaling by FGFR2 IIIa TM	R-HSA-8851708	0.712198	0.147
Maturation of nucleoprotein	R-HSA-9694631	0.712198	0.147
Cargo trafficking to the periciliary membrane	R-HSA-5620920	0.713082	0.147
Interleukin-21 signaling	R-HSA-9020958	0.713117	0.147
CASP8 activity is inhibited	R-HSA-5218900	0.713117	0.147
Defects in biotin (Btn) metabolism	R-HSA-3323169	0.713117	0.147
Unwinding of DNA	R-HSA-176974	0.713117	0.147
MASTL Facilitates Mitotic Progression	R-HSA-2465910	0.713117	0.147
Activation of the AP-1 family of transcription factors	R-HSA-450341	0.713117	0.147
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	0.713117	0.147
ARMS-mediated activation	R-HSA-170984	0.713117	0.147
Regulation of signaling by NODAL	R-HSA-1433617	0.713117	0.147
Regulation of CDH11 gene transcription	R-HSA-9762293	0.713117	0.147
Interleukin-1 processing	R-HSA-448706	0.713117	0.147
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	0.713117	0.147
Butyrophilin (BTN) family interactions	R-HSA-8851680	0.713117	0.147
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	0.719427	0.143
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	0.719427	0.143
Inhibition of DNA recombination at telomere	R-HSA-9670095	0.719427	0.143
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	0.719427	0.143
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	0.719427	0.143
Formation of Incision Complex in GG-NER	R-HSA-5696395	0.719427	0.143
Nuclear signaling by ERBB4	R-HSA-1251985	0.719427	0.143
Regulation of RAS by GAPs	R-HSA-5658442	0.719827	0.143
Programmed Cell Death	R-HSA-5357801	0.720001	0.143
MyD88-independent TLR4 cascade	R-HSA-166166	0.721708	0.142
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	0.721708	0.142
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	0.724939	0.140
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	0.726768	0.139
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	0.726768	0.139
Regulation of PD-L1(CD274) translation	R-HSA-9909620	0.732941	0.135
PI-3K cascade:FGFR4	R-HSA-5654720	0.732941	0.135
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	0.732941	0.135
Signaling by NODAL	R-HSA-1181150	0.732941	0.135
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	0.734389	0.134
FLT3 Signaling	R-HSA-9607240	0.734389	0.134
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	0.736455	0.133
DNA Repair	R-HSA-73894	0.736726	0.133
Cargo concentration in the ER	R-HSA-5694530	0.739208	0.131
S Phase	R-HSA-69242	0.741297	0.130
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	0.741479	0.130
TET1,2,3 and TDG demethylate DNA	R-HSA-5221030	0.741479	0.130
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	0.741479	0.130
CASP4 inflammasome assembly	R-HSA-9948001	0.741479	0.130
2-LTR circle formation	R-HSA-164843	0.741479	0.130
Receptor Mediated Mitophagy	R-HSA-8934903	0.741479	0.130
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	0.741479	0.130
Metal sequestration by antimicrobial proteins	R-HSA-6799990	0.741479	0.130
Josephin domain DUBs	R-HSA-5689877	0.741479	0.130
Unfolded Protein Response (UPR)	R-HSA-381119	0.744777	0.128
RNA Polymerase I Promoter Escape	R-HSA-73772	0.746432	0.127
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	0.746432	0.127
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	0.748742	0.126
HIV Transcription Initiation	R-HSA-167161	0.748742	0.126
RNA Polymerase II Transcription Initiation	R-HSA-75953	0.748742	0.126
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	0.748742	0.126
Intra-Golgi traffic	R-HSA-6811438	0.748742	0.126
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	0.749514	0.125
Cilium Assembly	R-HSA-5617833	0.752210	0.124
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	0.752398	0.124
SHC-mediated cascade:FGFR3	R-HSA-5654704	0.752398	0.124
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	0.752398	0.124
MyD88 deficiency (TLR2/4)	R-HSA-5602498	0.752398	0.124
Signalling to RAS	R-HSA-167044	0.752398	0.124
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	0.752398	0.124
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	0.752398	0.124
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	0.753209	0.123
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	0.753209	0.123
Opioid Signalling	R-HSA-111885	0.755213	0.122
Signaling by WNT in cancer	R-HSA-4791275	0.755227	0.122
Cardiac conduction	R-HSA-5576891	0.756944	0.121
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	0.759014	0.120
Smooth Muscle Contraction	R-HSA-445355	0.759014	0.120
RSV-host interactions	R-HSA-9833110	0.764285	0.117
ChREBP activates metabolic gene expression	R-HSA-163765	0.767039	0.115
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	0.767039	0.115
Presynaptic depolarization and calcium channel opening	R-HSA-112308	0.767039	0.115
LGI-ADAM interactions	R-HSA-5682910	0.767039	0.115
RHOBTB3 ATPase cycle	R-HSA-9706019	0.767039	0.115
Bicarbonate transporters	R-HSA-425381	0.767039	0.115
CD163 mediating an anti-inflammatory response	R-HSA-9662834	0.767039	0.115
SARS-CoV-2 modulates autophagy	R-HSA-9754560	0.767039	0.115
Biosynthesis of DPAn-3-derived maresins	R-HSA-9026290	0.767039	0.115
Interleukin-2 signaling	R-HSA-9020558	0.767039	0.115
RNA Polymerase I Promoter Clearance	R-HSA-73854	0.768963	0.114
Cellular response to hypoxia	R-HSA-1234174	0.769235	0.114
Negative regulation of FGFR1 signaling	R-HSA-5654726	0.770442	0.113
Assembly of the ORC complex at the origin of replication	R-HSA-68616	0.770442	0.113
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	0.770619	0.113
SHC-mediated cascade:FGFR4	R-HSA-5654719	0.770619	0.113
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	0.770619	0.113
Attachment and Entry	R-HSA-9694614	0.770619	0.113
Listeria monocytogenes entry into host cells	R-HSA-8876384	0.770619	0.113
Mitochondrial calcium ion transport	R-HSA-8949215	0.770619	0.113
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	0.770619	0.113
Assembly Of The HIV Virion	R-HSA-175474	0.770619	0.113
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	0.770619	0.113
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	0.773119	0.112
TP53 Regulates Metabolic Genes	R-HSA-5628897	0.775379	0.110
RNA Polymerase II Promoter Escape	R-HSA-73776	0.775650	0.110
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	0.775650	0.110
Post NMDA receptor activation events	R-HSA-438064	0.779297	0.108
Regulation of T cell activation by CD28 family	R-HSA-388841	0.782708	0.106
DNA Damage Recognition in GG-NER	R-HSA-5696394	0.784875	0.105
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	0.784875	0.105
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	0.784875	0.105
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	0.784875	0.105
PI-3K cascade:FGFR1	R-HSA-5654689	0.787659	0.104
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	0.787659	0.104
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	0.787659	0.104
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	0.787659	0.104
RAF-independent MAPK1/3 activation	R-HSA-112409	0.787659	0.104
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	0.787659	0.104
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	0.788225	0.103
Surfactant metabolism	R-HSA-5683826	0.788225	0.103
Amine ligand-binding receptors	R-HSA-375280	0.788225	0.103
Selective autophagy	R-HSA-9663891	0.788572	0.103
Nuclear Receptor transcription pathway	R-HSA-383280	0.788944	0.103
RNA Polymerase I Transcription	R-HSA-73864	0.788944	0.103
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	0.790073	0.102
Integration of provirus	R-HSA-162592	0.790073	0.102
Sensing of DNA Double Strand Breaks	R-HSA-5693548	0.790073	0.102
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	0.790073	0.102
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	0.790073	0.102
Anchoring fibril formation	R-HSA-2214320	0.790073	0.102
Sodium/Calcium exchangers	R-HSA-425561	0.790073	0.102
Uptake of dietary cobalamins into enterocytes	R-HSA-9758881	0.790073	0.102
SARS-CoV-1 Infection	R-HSA-9678108	0.791881	0.101
Ion homeostasis	R-HSA-5578775	0.793930	0.100
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	0.793930	0.100
Regulation of insulin secretion	R-HSA-422356	0.797561	0.098
Signaling by NOTCH2	R-HSA-1980145	0.798548	0.098
Negative regulation of FGFR2 signaling	R-HSA-5654727	0.798548	0.098
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	0.798548	0.098
Mitochondrial biogenesis	R-HSA-1592230	0.799302	0.097
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	0.800230	0.097
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	0.800230	0.097
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	0.800230	0.097
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	0.800592	0.097
Termination of O-glycan biosynthesis	R-HSA-977068	0.803574	0.095
Syndecan interactions	R-HSA-3000170	0.803574	0.095
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	0.803574	0.095
Carnitine shuttle	R-HSA-200425	0.803574	0.095
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	0.806359	0.093
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	0.807599	0.093
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	0.809386	0.092
Defective EXT2 causes exostoses 2	R-HSA-3656237	0.810831	0.091
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	R-HSA-3656253	0.810831	0.091
Scavenging by Class F Receptors	R-HSA-3000484	0.810831	0.091
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	0.810831	0.091
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	0.810831	0.091
Repression of WNT target genes	R-HSA-4641265	0.810831	0.091
GRB2 events in EGFR signaling	R-HSA-179812	0.810831	0.091
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	0.810831	0.091
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	0.810831	0.091
Serotonin clearance from the synaptic cleft	R-HSA-380615	0.810831	0.091
MET activates RAS signaling	R-HSA-8851805	0.810831	0.091
Interleukin-15 signaling	R-HSA-8983432	0.810831	0.091
Biosynthesis of DPAn-3-derived protectins and resolvins	R-HSA-9026286	0.810831	0.091
Diseases associated with surfactant metabolism	R-HSA-5687613	0.810831	0.091
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	0.810831	0.091
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	0.810831	0.091
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	0.810831	0.091
Estrogen biosynthesis	R-HSA-193144	0.810831	0.091
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	0.810831	0.091
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	0.811678	0.091
Dual incision in TC-NER	R-HSA-6782135	0.814918	0.089
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	0.816439	0.088
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	0.817521	0.088
SHC-mediated cascade:FGFR1	R-HSA-5654688	0.818419	0.087
TRAF6 mediated NF-kB activation	R-HSA-933542	0.818419	0.087
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	0.818419	0.087
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	0.818419	0.087
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	0.818419	0.087
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	0.819595	0.086
Degradation of beta-catenin by the destruction complex	R-HSA-195253	0.819595	0.086
Recycling pathway of L1	R-HSA-437239	0.822584	0.085
Triglyceride catabolism	R-HSA-163560	0.823713	0.084
G1/S-Specific Transcription	R-HSA-69205	0.823713	0.084
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	0.824752	0.084
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	0.824960	0.084
Regulation of mitotic cell cycle	R-HSA-453276	0.828544	0.082
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	0.828544	0.082
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	0.829537	0.081
FGFR1c ligand binding and activation	R-HSA-190373	0.829537	0.081
Mtb iron assimilation by chelation	R-HSA-1222449	0.829537	0.081
PI5P Regulates TP53 Acetylation	R-HSA-6811555	0.829537	0.081
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	0.829537	0.081
Processing of SMDT1	R-HSA-8949664	0.829537	0.081
CD28 dependent Vav1 pathway	R-HSA-389359	0.829537	0.081
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	0.829537	0.081
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	0.829537	0.081
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	0.829988	0.081
Signaling by Insulin receptor	R-HSA-74752	0.830628	0.081
PI-3K cascade:FGFR2	R-HSA-5654695	0.832249	0.080
Tight junction interactions	R-HSA-420029	0.832249	0.080
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	0.832249	0.080
Acyl chain remodelling of PS	R-HSA-1482801	0.832249	0.080
VEGFR2 mediated cell proliferation	R-HSA-5218921	0.832249	0.080
C-type lectin receptors (CLRs)	R-HSA-5621481	0.832448	0.080
Metal ion SLC transporters	R-HSA-425410	0.832962	0.079
TRAF6 mediated IRF7 activation	R-HSA-933541	0.835256	0.078
SIRT1 negatively regulates rRNA expression	R-HSA-427359	0.835256	0.078
Collagen chain trimerization	R-HSA-8948216	0.835256	0.078
Pre-NOTCH Expression and Processing	R-HSA-1912422	0.835364	0.078
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	0.835377	0.078
trans-Golgi Network Vesicle Budding	R-HSA-199992	0.837136	0.077
Organelle biogenesis and maintenance	R-HSA-1852241	0.840842	0.075
Regulation of RUNX2 expression and activity	R-HSA-8939902	0.843147	0.074
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	0.845122	0.073
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	0.845122	0.073
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	0.845122	0.073
Prolactin receptor signaling	R-HSA-1170546	0.846395	0.072
Hydrolysis of LPC	R-HSA-1483115	0.846395	0.072
Biosynthesis of E-series 18(R)-resolvins	R-HSA-9023661	0.846395	0.072
cGMP effects	R-HSA-418457	0.846395	0.072
Physiological factors	R-HSA-5578768	0.846395	0.072
Malate-aspartate shuttle	R-HSA-9856872	0.846395	0.072
Regulation of KIT signaling	R-HSA-1433559	0.846395	0.072
Acyl chain remodeling of CL	R-HSA-1482798	0.846395	0.072
Zinc transporters	R-HSA-435354	0.846395	0.072
Signaling by FGFR2 in disease	R-HSA-5655253	0.852200	0.069
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	0.852543	0.069
SARS-CoV-2-host interactions	R-HSA-9705683	0.854578	0.068
Stabilization of p53	R-HSA-69541	0.856396	0.067
Plasma lipoprotein clearance	R-HSA-8964043	0.856396	0.067
SHC-mediated cascade:FGFR2	R-HSA-5654699	0.857090	0.067
Packaging Of Telomere Ends	R-HSA-171306	0.857090	0.067
Signaling by BMP	R-HSA-201451	0.857090	0.067
Cristae formation	R-HSA-8949613	0.857090	0.067
RNA Polymerase I Promoter Opening	R-HSA-73728	0.857090	0.067
Signaling by FGFR3 in disease	R-HSA-5655332	0.857090	0.067
Maturation of hRSV A proteins	R-HSA-9828806	0.857090	0.067
Signaling by NOTCH	R-HSA-157118	0.860343	0.065
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	0.860840	0.065
Protein ubiquitination	R-HSA-8852135	0.860840	0.065
Activation of NF-kappaB in B cells	R-HSA-1169091	0.861093	0.065
Hedgehog ligand biogenesis	R-HSA-5358346	0.861093	0.065
The phototransduction cascade	R-HSA-2514856	0.861093	0.065
RNA Polymerase III Chain Elongation	R-HSA-73780	0.861586	0.065
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	0.861586	0.065
G beta:gamma signalling through BTK	R-HSA-8964315	0.861586	0.065
Protein lipoylation	R-HSA-9857492	0.861586	0.065
Translesion synthesis by REV1	R-HSA-110312	0.861586	0.065
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	0.861586	0.065
Biotin transport and metabolism	R-HSA-196780	0.861586	0.065
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	0.861586	0.065
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	0.861586	0.065
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	0.861586	0.065
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	0.861586	0.065
Other semaphorin interactions	R-HSA-416700	0.861586	0.065
IRF3-mediated induction of type I IFN	R-HSA-3270619	0.861586	0.065
DNA Damage Reversal	R-HSA-73942	0.861586	0.065
Regulation of RUNX3 expression and activity	R-HSA-8941858	0.866048	0.062
Developmental Cell Lineages	R-HSA-9734767	0.867086	0.062
Pyroptosis	R-HSA-5620971	0.868207	0.061
Telomere Extension By Telomerase	R-HSA-171319	0.868207	0.061
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	0.869524	0.061
Uptake and actions of bacterial toxins	R-HSA-5339562	0.869524	0.061
Co-inhibition by PD-1	R-HSA-389948	0.869714	0.061
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	0.869714	0.061
Integration of energy metabolism	R-HSA-163685	0.869915	0.061
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	0.875123	0.058
Translesion synthesis by POLI	R-HSA-5656121	0.875276	0.058
Phase 4 - resting membrane potential	R-HSA-5576886	0.875276	0.058
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	0.875276	0.058
Differentiation of T cells	R-HSA-9945266	0.875276	0.058
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	0.875276	0.058
Attachment and Entry	R-HSA-9678110	0.875276	0.058
Regulation of PTEN stability and activity	R-HSA-8948751	0.877511	0.057
Amino acids regulate mTORC1	R-HSA-9639288	0.877511	0.057
Post-translational protein phosphorylation	R-HSA-8957275	0.878160	0.056
mRNA Capping	R-HSA-72086	0.878523	0.056
Termination of translesion DNA synthesis	R-HSA-5656169	0.878523	0.056
Platelet calcium homeostasis	R-HSA-418360	0.878523	0.056
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	0.878523	0.056
Degradation of CRY and PER proteins	R-HSA-9932298	0.883648	0.054
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	0.885070	0.053
G beta:gamma signalling through CDC42	R-HSA-8964616	0.887612	0.052
SHC1 events in ERBB4 signaling	R-HSA-1250347	0.887612	0.052
Translesion synthesis by POLK	R-HSA-5655862	0.887612	0.052
Defective B4GALT7 causes EDS, progeroid type	R-HSA-3560783	0.887612	0.052
Defective B3GALT6 causes EDSP2 and SEMDJL1	R-HSA-4420332	0.887612	0.052
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	0.887612	0.052
Glycine degradation	R-HSA-6783984	0.887612	0.052
Transcriptional regulation of testis differentiation	R-HSA-9690406	0.887612	0.052
Vitamin B6 activation to pyridoxal phosphate	R-HSA-964975	0.887612	0.052
Passive transport by Aquaporins	R-HSA-432047	0.887612	0.052
Fibronectin matrix formation	R-HSA-1566977	0.887612	0.052
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	0.887612	0.052
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	0.887612	0.052
Response to metal ions	R-HSA-5660526	0.887612	0.052
Sensory processing of sound	R-HSA-9659379	0.887937	0.052
Downregulation of ERBB2 signaling	R-HSA-8863795	0.888089	0.052
Potential therapeutics for SARS	R-HSA-9679191	0.888514	0.051
Parasite infection	R-HSA-9664407	0.889746	0.051
Leishmania phagocytosis	R-HSA-9664417	0.889746	0.051
FCGR3A-mediated phagocytosis	R-HSA-9664422	0.889746	0.051
Cleavage of the damaged pyrimidine	R-HSA-110329	0.891651	0.050
Depyrimidination	R-HSA-73928	0.891651	0.050
Cytosolic tRNA aminoacylation	R-HSA-379716	0.891651	0.050
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	0.892219	0.050
Chromosome Maintenance	R-HSA-73886	0.893581	0.049
Budding and maturation of HIV virion	R-HSA-162588	0.896952	0.047
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	0.896952	0.047
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	0.896952	0.047
Defective B3GAT3 causes JDSSDHD	R-HSA-3560801	0.898729	0.046
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	0.898729	0.046
Biosynthesis of aspirin-triggered D-series resolvins	R-HSA-9020265	0.898729	0.046
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	0.898729	0.046
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	0.898729	0.046
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	0.898729	0.046
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	0.898976	0.046
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	0.898976	0.046
Hh mutants abrogate ligand secretion	R-HSA-5387390	0.899156	0.046
Defective pyroptosis	R-HSA-9710421	0.899156	0.046
Amyloid fiber formation	R-HSA-977225	0.899717	0.046
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	0.899994	0.046
Selenoamino acid metabolism	R-HSA-2408522	0.900271	0.046
Golgi-to-ER retrograde transport	R-HSA-8856688	0.900547	0.045
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	0.905157	0.043
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	0.905157	0.043
G beta:gamma signalling through PLC beta	R-HSA-418217	0.908747	0.042
Presynaptic function of Kainate receptors	R-HSA-500657	0.908747	0.042
Biosynthesis of Lipoxins (LX)	R-HSA-2142700	0.908747	0.042
FGFR1 ligand binding and activation	R-HSA-190242	0.908747	0.042
Mismatch Repair	R-HSA-5358508	0.908747	0.042
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	0.908747	0.042
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	0.908747	0.042
Apoptotic factor-mediated response	R-HSA-111471	0.908747	0.042
PPARA activates gene expression	R-HSA-1989781	0.909339	0.041
Signaling by Interleukins	R-HSA-449147	0.911231	0.040
Early SARS-CoV-2 Infection Events	R-HSA-9772572	0.911376	0.040
Neddylation	R-HSA-8951664	0.911738	0.040
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	0.912688	0.040
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	0.912688	0.040
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	0.912748	0.040
Regulation of necroptotic cell death	R-HSA-5675482	0.912748	0.040
Activation of ATR in response to replication stress	R-HSA-176187	0.912748	0.040
Defective CFTR causes cystic fibrosis	R-HSA-5678895	0.912775	0.040
Fanconi Anemia Pathway	R-HSA-6783310	0.912775	0.040
Ion channel transport	R-HSA-983712	0.913245	0.039
G1/S Transition	R-HSA-69206	0.915604	0.038
Triglyceride metabolism	R-HSA-8979227	0.917053	0.038
Pre-NOTCH Processing in Golgi	R-HSA-1912420	0.917775	0.037
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	0.917775	0.037
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	0.917775	0.037
Translesion Synthesis by POLH	R-HSA-110320	0.917775	0.037
Synthesis of 5-eicosatetraenoic acids	R-HSA-2142688	0.917775	0.037
O2/CO2 exchange in erythrocytes	R-HSA-1480926	0.917775	0.037
Crosslinking of collagen fibrils	R-HSA-2243919	0.917775	0.037
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	0.917775	0.037
STING mediated induction of host immune responses	R-HSA-1834941	0.917775	0.037
Nucleotide Excision Repair	R-HSA-5696398	0.918431	0.037
Effects of PIP2 hydrolysis	R-HSA-114508	0.919766	0.036
Miscellaneous transport and binding events	R-HSA-5223345	0.919766	0.036
Toll-like Receptor Cascades	R-HSA-168898	0.919804	0.036
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	0.922084	0.035
Sphingolipid de novo biosynthesis	R-HSA-1660661	0.922402	0.035
tRNA Aminoacylation	R-HSA-379724	0.922402	0.035
Platelet homeostasis	R-HSA-418346	0.922557	0.035
Vesicle-mediated transport	R-HSA-5653656	0.923010	0.035
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	0.924700	0.034
Co-inhibition by CTLA4	R-HSA-389513	0.925909	0.033
Negative regulation of MET activity	R-HSA-6807004	0.925909	0.033
Acyl chain remodelling of PI	R-HSA-1482922	0.925909	0.033
Common Pathway of Fibrin Clot Formation	R-HSA-140875	0.925909	0.033
Pregnenolone biosynthesis	R-HSA-196108	0.925909	0.033
Signal transduction by L1	R-HSA-445144	0.925909	0.033
Eicosanoid ligand-binding receptors	R-HSA-391903	0.925909	0.033
Dual Incision in GG-NER	R-HSA-5696400	0.926250	0.033
eNOS activation	R-HSA-203615	0.926250	0.033
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	0.926250	0.033
Signal amplification	R-HSA-392518	0.926250	0.033
Regulation of TLR by endogenous ligand	R-HSA-5686938	0.926250	0.033
CLEC7A (Dectin-1) signaling	R-HSA-5607764	0.927229	0.033
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	0.927229	0.033
Signaling by NOTCH4	R-HSA-9013694	0.927433	0.033
Formation of paraxial mesoderm	R-HSA-9793380	0.927440	0.033
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	0.930085	0.031
Telomere Maintenance	R-HSA-157579	0.931150	0.031
Non-integrin membrane-ECM interactions	R-HSA-3000171	0.931831	0.031
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	0.932180	0.031
NCAM signaling for neurite out-growth	R-HSA-375165	0.932180	0.031
Early Phase of HIV Life Cycle	R-HSA-162594	0.933240	0.030
Biosynthesis of E-series 18(S)-resolvins	R-HSA-9018896	0.933240	0.030
Phenylalanine metabolism	R-HSA-8964208	0.933240	0.030
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	0.933240	0.030
Basigin interactions	R-HSA-210991	0.933240	0.030
Acyl chain remodelling of PG	R-HSA-1482925	0.933240	0.030
Degradation of CDH1	R-HSA-9766229	0.935114	0.029
Platelet activation, signaling and aggregation	R-HSA-76002	0.935229	0.029
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	0.937012	0.028
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	0.937761	0.028
Lysosome Vesicle Biogenesis	R-HSA-432720	0.937761	0.028
FGFR2 mutant receptor activation	R-HSA-1839126	0.937761	0.028
Interleukin-1 family signaling	R-HSA-446652	0.937823	0.028
Adaptive Immune System	R-HSA-1280218	0.938424	0.028
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	0.939846	0.027
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	0.939846	0.027
FRS-mediated FGFR3 signaling	R-HSA-5654706	0.939846	0.027
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	0.939846	0.027
Glutathione synthesis and recycling	R-HSA-174403	0.939846	0.027
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	0.940829	0.026
Voltage gated Potassium channels	R-HSA-1296072	0.942857	0.026
Cleavage of the damaged purine	R-HSA-110331	0.942857	0.026
NCAM1 interactions	R-HSA-419037	0.942857	0.026
Integrin cell surface interactions	R-HSA-216083	0.943630	0.025
Downstream TCR signaling	R-HSA-202424	0.943904	0.025
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	0.945569	0.024
Regulation of IFNA/IFNB signaling	R-HSA-912694	0.945798	0.024
FRS-mediated FGFR4 signaling	R-HSA-5654712	0.945798	0.024
Biosynthesis of D-series resolvins	R-HSA-9018676	0.945798	0.024
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	0.945798	0.024
Signaling by KIT in disease	R-HSA-9669938	0.945798	0.024
Cellular hexose transport	R-HSA-189200	0.945798	0.024
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	0.947553	0.023
RIPK1-mediated regulated necrosis	R-HSA-5213460	0.947553	0.023
Depurination	R-HSA-73927	0.947553	0.023
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	0.947789	0.023
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	0.948262	0.023
Orc1 removal from chromatin	R-HSA-68949	0.948262	0.023
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	0.948262	0.023
Parasitic Infection Pathways	R-HSA-9824443	0.949698	0.022
Leishmania infection	R-HSA-9658195	0.949698	0.022
PKR-mediated signaling	R-HSA-9833482	0.950438	0.022
HCMV Late Events	R-HSA-9610379	0.950787	0.022
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	0.951162	0.022
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	0.951162	0.022
Free fatty acids regulate insulin secretion	R-HSA-400451	0.951162	0.022
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	0.951162	0.022
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	0.951162	0.022
Biosynthesis of maresins	R-HSA-9018682	0.951162	0.022
Interleukin-20 family signaling	R-HSA-8854691	0.951162	0.022
Neutrophil degranulation	R-HSA-6798695	0.951248	0.022
SARS-CoV-2 Infection	R-HSA-9694516	0.951795	0.021
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	0.951880	0.021
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	0.951880	0.021
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	0.952062	0.021
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	0.952234	0.021
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	0.953075	0.021
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	0.953236	0.021
Late SARS-CoV-2 Infection Events	R-HSA-9772573	0.953236	0.021
Regulated Necrosis	R-HSA-5218859	0.955181	0.020
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	0.955181	0.020
Base-Excision Repair, AP Site Formation	R-HSA-73929	0.955601	0.020
Diseases associated with the TLR signaling cascade	R-HSA-5602358	0.955865	0.020
Diseases of Immune System	R-HSA-5260271	0.955865	0.020
Complex III assembly	R-HSA-9865881	0.955995	0.020
Thromboxane signalling through TP receptor	R-HSA-428930	0.955995	0.020
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	0.955995	0.020
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	0.955995	0.020
Synthesis of dolichyl-phosphate	R-HSA-446199	0.955995	0.020
TNFs bind their physiological receptors	R-HSA-5669034	0.955995	0.020
Assembly of the pre-replicative complex	R-HSA-68867	0.956020	0.020
FCERI mediated Ca+2 mobilization	R-HSA-2871809	0.957259	0.019
Collagen formation	R-HSA-1474290	0.958653	0.018
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	0.958893	0.018
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	0.959533	0.018
Hh mutants are degraded by ERAD	R-HSA-5362768	0.959533	0.018
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	0.959533	0.018
Maturation of spike protein	R-HSA-9694548	0.959533	0.018
HCMV Early Events	R-HSA-9609690	0.960059	0.018
FRS-mediated FGFR1 signaling	R-HSA-5654693	0.960350	0.018
Long-term potentiation	R-HSA-9620244	0.960350	0.018
Laminin interactions	R-HSA-3000157	0.960350	0.018
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives	R-HSA-9027604	0.960350	0.018
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	0.960350	0.018
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	0.961859	0.017
Translation of Structural Proteins	R-HSA-9683701	0.962907	0.016
KEAP1-NFE2L2 pathway	R-HSA-9755511	0.963419	0.016
MET activates PTK2 signaling	R-HSA-8874081	0.964274	0.016
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	0.964274	0.016
Attachment of bacteria to epithelial cells	R-HSA-9638630	0.964274	0.016
Regulation of CDH1 Function	R-HSA-9764561	0.964802	0.016
SARS-CoV Infections	R-HSA-9679506	0.965145	0.015
Cellular response to chemical stress	R-HSA-9711123	0.965345	0.015
COPI-mediated anterograde transport	R-HSA-6807878	0.965716	0.015
Activation of GABAB receptors	R-HSA-991365	0.966010	0.015
GABA B receptor activation	R-HSA-977444	0.966010	0.015
Incretin synthesis, secretion, and inactivation	R-HSA-400508	0.966010	0.015
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	0.966614	0.015
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	0.967810	0.014
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	0.967810	0.014
Biosynthesis of DPAn-3 SPMs	R-HSA-9025094	0.967810	0.014
Processive synthesis on the C-strand of the telomere	R-HSA-174414	0.967810	0.014
Triglyceride biosynthesis	R-HSA-75109	0.967810	0.014
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	0.967810	0.014
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	0.967810	0.014
Insulin processing	R-HSA-264876	0.967810	0.014
Switching of origins to a post-replicative state	R-HSA-69052	0.968598	0.014
Response of Mtb to phagocytosis	R-HSA-9637690	0.968862	0.014
SLC transporter disorders	R-HSA-5619102	0.969804	0.013
Regulation of beta-cell development	R-HSA-186712	0.969904	0.013
Extension of Telomeres	R-HSA-180786	0.969904	0.013
FRS-mediated FGFR2 signaling	R-HSA-5654700	0.970997	0.013
Activation of kainate receptors upon glutamate binding	R-HSA-451326	0.970997	0.013
Pyrimidine salvage	R-HSA-73614	0.970997	0.013
Proteasome assembly	R-HSA-9907900	0.971483	0.013
GABA receptor activation	R-HSA-977443	0.972184	0.012
FCERI mediated MAPK activation	R-HSA-2871796	0.972952	0.012
Thyroxine biosynthesis	R-HSA-209968	0.973868	0.011
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	0.973868	0.011
Regulation of gene expression in beta cells	R-HSA-210745	0.973868	0.011
Biosynthesis of EPA-derived SPMs	R-HSA-9018679	0.973868	0.011
Signaling by CSF3 (G-CSF)	R-HSA-9674555	0.973868	0.011
Activation of Matrix Metalloproteinases	R-HSA-1592389	0.973868	0.011
Asymmetric localization of PCP proteins	R-HSA-4608870	0.973891	0.011
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	0.973891	0.011
Somitogenesis	R-HSA-9824272	0.973891	0.011
Collagen degradation	R-HSA-1442490	0.974300	0.011
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	0.976101	0.011
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	0.976263	0.010
Activation of the pre-replicative complex	R-HSA-68962	0.976455	0.010
GABA synthesis, release, reuptake and degradation	R-HSA-888590	0.976455	0.010
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	0.976455	0.010
Neurotransmitter clearance	R-HSA-112311	0.976455	0.010
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	0.976455	0.010
Activation of BH3-only proteins	R-HSA-114452	0.976455	0.010
ER to Golgi Anterograde Transport	R-HSA-199977	0.976520	0.010
Translation of Structural Proteins	R-HSA-9694635	0.976524	0.010
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	0.978130	0.010
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	0.978130	0.010
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	0.978786	0.009
Molecules associated with elastic fibres	R-HSA-2129379	0.978786	0.009
Biosynthesis of DPA-derived SPMs	R-HSA-9018683	0.978786	0.009
Interferon Signaling	R-HSA-913531	0.979281	0.009
Platelet degranulation	R-HSA-114608	0.979867	0.009
Gluconeogenesis	R-HSA-70263	0.979991	0.009
Interferon alpha/beta signaling	R-HSA-909733	0.980140	0.009
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	0.980886	0.008
HS-GAG degradation	R-HSA-2024096	0.980886	0.008
DNA strand elongation	R-HSA-69190	0.980886	0.008
Phospholipid metabolism	R-HSA-1483257	0.981639	0.008
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	0.981960	0.008
Defective B3GALTL causes PpS	R-HSA-5083635	0.982779	0.008
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	0.982779	0.008
Recycling of bile acids and salts	R-HSA-159418	0.982779	0.008
Mitochondrial protein degradation	R-HSA-9837999	0.983179	0.007
Acyl chain remodelling of PC	R-HSA-1482788	0.984484	0.007
Vpu mediated degradation of CD4	R-HSA-180534	0.984484	0.007
Heme degradation	R-HSA-189483	0.984484	0.007
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	0.984699	0.007
Cytosolic sulfonation of small molecules	R-HSA-156584	0.984699	0.007
O-linked glycosylation of mucins	R-HSA-913709	0.985353	0.006
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	0.985353	0.006
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	0.986021	0.006
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	0.986021	0.006
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	0.986021	0.006
Mitophagy	R-HSA-5205647	0.986021	0.006
Phosphate bond hydrolysis by NUDT proteins	R-HSA-2393930	0.986021	0.006
DNA Replication Pre-Initiation	R-HSA-69002	0.986229	0.006
Cytokine Signaling in Immune system	R-HSA-1280215	0.987184	0.006
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	0.987405	0.006
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	0.987405	0.006
Acyl chain remodelling of PE	R-HSA-1482839	0.987405	0.006
Defects in vitamin and cofactor metabolism	R-HSA-3296482	0.987405	0.006
Regulation of Apoptosis	R-HSA-169911	0.987405	0.006
Transferrin endocytosis and recycling	R-HSA-917977	0.987405	0.006
tRNA processing	R-HSA-72306	0.987418	0.005
COPII-mediated vesicle transport	R-HSA-204005	0.987559	0.005
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	0.988323	0.005
ECM proteoglycans	R-HSA-3000178	0.988538	0.005
HS-GAG biosynthesis	R-HSA-2022928	0.988652	0.005
Vif-mediated degradation of APOBEC3G	R-HSA-180585	0.988652	0.005
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	0.988652	0.005
O-glycosylation of TSR domain-containing proteins	R-HSA-5173214	0.989776	0.004
Degradation of AXIN	R-HSA-4641257	0.989776	0.004
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	0.989776	0.004
SLC-mediated transport of organic cations	R-HSA-549127	0.989776	0.004
Phenylalanine and tyrosine metabolism	R-HSA-8963691	0.989776	0.004
Detoxification of Reactive Oxygen Species	R-HSA-3299685	0.990258	0.004
Intrinsic Pathway for Apoptosis	R-HSA-109606	0.990258	0.004
Interleukin-1 signaling	R-HSA-9020702	0.990486	0.004
Elastic fibre formation	R-HSA-1566948	0.990789	0.004
Biofilm formation	R-HSA-9931953	0.990789	0.004
SLC-mediated transport of inorganic anions	R-HSA-9958790	0.990789	0.004
Synthesis of PA	R-HSA-1483166	0.991104	0.004
Dectin-2 family	R-HSA-5621480	0.991104	0.004
ER-Phagosome pathway	R-HSA-1236974	0.991179	0.004
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	0.991701	0.004
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	0.991701	0.004
Iron uptake and transport	R-HSA-917937	0.991763	0.004
Class B/2 (Secretin family receptors)	R-HSA-373080	0.991834	0.004
UCH proteinases	R-HSA-5689603	0.992420	0.003
Negative regulation of NOTCH4 signaling	R-HSA-9604323	0.992523	0.003
Tryptophan catabolism	R-HSA-71240	0.992523	0.003
Mitochondrial tRNA aminoacylation	R-HSA-379726	0.992523	0.003
Amino acid transport across the plasma membrane	R-HSA-352230	0.992587	0.003
RAB geranylgeranylation	R-HSA-8873719	0.993235	0.003
Signaling by Retinoic Acid	R-HSA-5362517	0.993235	0.003
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	0.993264	0.003
Resolution of Abasic Sites (AP sites)	R-HSA-73933	0.993264	0.003
ABC transporter disorders	R-HSA-5619084	0.993586	0.003
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	0.993932	0.003
Scavenging by Class A Receptors	R-HSA-3000480	0.993932	0.003
SLC-mediated transport of neurotransmitters	R-HSA-442660	0.993932	0.003
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	0.993932	0.003
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	0.994102	0.003
Degradation of the extracellular matrix	R-HSA-1474228	0.994231	0.003
Mitochondrial protein import	R-HSA-1268020	0.994368	0.002
Interferon gamma signaling	R-HSA-877300	0.994661	0.002
Transmission across Chemical Synapses	R-HSA-112315	0.994750	0.002
Nuclear events mediated by NFE2L2	R-HSA-9759194	0.994760	0.002
Defensins	R-HSA-1461973	0.995075	0.002
HCMV Infection	R-HSA-9609646	0.995079	0.002
Ion transport by P-type ATPases	R-HSA-936837	0.995315	0.002
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	0.995563	0.002
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	0.995563	0.002
Formation of the cornified envelope	R-HSA-6809371	0.995767	0.002
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	0.995792	0.002
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	0.996002	0.002
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	0.996399	0.002
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	0.996399	0.002
SLC-mediated transport of amino acids	R-HSA-9958863	0.996449	0.002
Metabolism of steroid hormones	R-HSA-196071	0.996449	0.002
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	0.996755	0.001
DNA Replication	R-HSA-69306	0.996805	0.001
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	0.997007	0.001
Intraflagellar transport	R-HSA-5620924	0.997077	0.001
Disorders of transmembrane transporters	R-HSA-5619115	0.997104	0.001
Neuronal System	R-HSA-112316	0.997219	0.001
Chaperonin-mediated protein folding	R-HSA-390466	0.997252	0.001
Gap junction trafficking and regulation	R-HSA-157858	0.997367	0.001
Glyoxylate metabolism and glycine degradation	R-HSA-389661	0.997367	0.001
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	0.997367	0.001
Chemokine receptors bind chemokines	R-HSA-380108	0.997367	0.001
Retinoid metabolism and transport	R-HSA-975634	0.997551	0.001
Metabolism of cofactors	R-HSA-8978934	0.997551	0.001
Complex IV assembly	R-HSA-9864848	0.997863	0.001
Neurotransmitter release cycle	R-HSA-112310	0.997877	0.001
Base Excision Repair	R-HSA-73884	0.997877	0.001
Synthesis of DNA	R-HSA-69239	0.998336	0.001
Protein folding	R-HSA-391251	0.998363	0.001
Antigen processing-Cross presentation	R-HSA-1236975	0.998467	0.001
MHC class II antigen presentation	R-HSA-2132295	0.998548	0.001
Metabolism of amine-derived hormones	R-HSA-209776	0.998732	0.001
Digestion	R-HSA-8935690	0.998732	0.001
Protein localization	R-HSA-9609507	0.998843	0.001
Viral Infection Pathways	R-HSA-9824446	0.998868	0.000
Translation	R-HSA-72766	0.998935	0.000
Metabolism of fat-soluble vitamins	R-HSA-6806667	0.999042	0.000
Heparan sulfate/heparin (HS-GAG) metabolism	R-HSA-1638091	0.999073	0.000
Peroxisomal protein import	R-HSA-9033241	0.999073	0.000
Sialic acid metabolism	R-HSA-4085001	0.999073	0.000
Glutathione conjugation	R-HSA-156590	0.999165	0.000
Metabolism of polyamines	R-HSA-351202	0.999165	0.000
Transport to the Golgi and subsequent modification	R-HSA-948021	0.999236	0.000
Endogenous sterols	R-HSA-211976	0.999248	0.000
Nucleotide salvage	R-HSA-8956321	0.999248	0.000
ABC-family proteins mediated transport	R-HSA-382556	0.999255	0.000
Peptide hormone metabolism	R-HSA-2980736	0.999382	0.000
Complex I biogenesis	R-HSA-6799198	0.999390	0.000
Digestion and absorption	R-HSA-8963743	0.999390	0.000
Visual phototransduction	R-HSA-2187338	0.999428	0.000
CD22 mediated BCR regulation	R-HSA-5690714	0.999450	0.000
Latent infection - Other responses of Mtb to phagocytosis	R-HSA-1222499	0.999505	0.000
Extracellular matrix organization	R-HSA-1474244	0.999510	0.000
G alpha (q) signalling events	R-HSA-416476	0.999511	0.000
tRNA modification in the nucleus and cytosol	R-HSA-6782315	0.999554	0.000
Hemostasis	R-HSA-109582	0.999590	0.000
Nicotinate metabolism	R-HSA-196807	0.999598	0.000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	0.999598	0.000
Fatty acyl-CoA biosynthesis	R-HSA-75105	0.999706	0.000
Glycosphingolipid catabolism	R-HSA-9840310	0.999706	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	0.999734	0.000
Metabolism of porphyrins	R-HSA-189445	0.999735	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	0.999755	0.000
Leishmania parasite growth and survival	R-HSA-9664433	0.999755	0.000
GPCR downstream signalling	R-HSA-388396	0.999761	0.000
Purine catabolism	R-HSA-74259	0.999762	0.000
FCERI mediated NF-kB activation	R-HSA-2871837	0.999803	0.000
ROS and RNS production in phagocytes	R-HSA-1222556	0.999807	0.000
Citric acid cycle (TCA cycle)	R-HSA-71403	0.999826	0.000
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	0.999826	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	0.999828	0.000
Potassium Channels	R-HSA-1296071	0.999828	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	0.999871	0.000
SLC-mediated transport of organic anions	R-HSA-9955298	0.999873	0.000
Cholesterol biosynthesis	R-HSA-191273	0.999873	0.000
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	0.999907	0.000
O-linked glycosylation	R-HSA-5173105	0.999913	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	0.999913	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	0.999916	0.000
Bile acid and bile salt metabolism	R-HSA-194068	0.999960	0.000
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	0.999960	0.000
Antimicrobial peptides	R-HSA-6803157	0.999963	0.000
Diseases of glycosylation	R-HSA-3781865	0.999972	0.000
Post-translational protein modification	R-HSA-597592	0.999987	0.000
Innate Immune System	R-HSA-168249	0.999994	0.000
Signaling by GPCR	R-HSA-372790	0.999994	0.000
Nucleotide catabolism	R-HSA-8956319	0.999995	0.000
Keratinization	R-HSA-6805567	0.999996	0.000
Immune System	R-HSA-168256	0.999996	0.000
Sensory perception of taste	R-HSA-9717189	0.999996	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	0.999996	0.000
Respiratory electron transport	R-HSA-611105	0.999998	0.000
G alpha (i) signalling events	R-HSA-418594	0.999998	0.000
Sphingolipid metabolism	R-HSA-428157	0.999999	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	0.999999	0.000
Metabolism of steroids	R-HSA-8957322	0.999999	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	0.999999	0.000
Glycosphingolipid metabolism	R-HSA-1660662	0.999999	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	1.000000	0.000
Arachidonate metabolism	R-HSA-2142753	1.000000	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	1.000000	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000	0.000
Disease	R-HSA-1643685	1.000000	0.000
Infectious disease	R-HSA-5663205	1.000000	0.000
Peptide ligand-binding receptors	R-HSA-375276	1.000000	0.000
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	1.000000	0.000
Asparagine N-linked glycosylation	R-HSA-446203	1.000000	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	1.000000	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000	0.000
Metabolism of nucleotides	R-HSA-15869	1.000000	0.000
SLC-mediated transmembrane transport	R-HSA-425407	1.000000	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000	0.000
Metabolism of proteins	R-HSA-392499	1.000000	0.000
Transport of small molecules	R-HSA-382551	1.000000	0.000
Infection with Enterobacteria	R-HSA-9640148	1.000000	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000	0.000
Diseases of metabolism	R-HSA-5668914	1.000000	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000	0.000
GPCR ligand binding	R-HSA-500792	1.000000	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000	-0.000
Metabolism of lipids	R-HSA-556833	1.000000	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000	-0.000
Metabolism	R-HSA-1430728	1.000000	-0.000
Sensory Perception	R-HSA-9709957	1.000000	-0.000
Biological oxidations	R-HSA-211859	1.000000	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Cellular responses to stress	R-HSA-2262752	1.110223e-16	15.955
Cellular responses to stimuli	R-HSA-8953897	1.110223e-16	15.955
Cell Cycle, Mitotic	R-HSA-69278	2.220446e-16	15.654
M Phase	R-HSA-68886	7.771561e-16	15.109
Cell Cycle	R-HSA-1640170	7.771561e-16	15.109
Axon guidance	R-HSA-422475	1.998401e-15	14.699
Nervous system development	R-HSA-9675108	6.550316e-15	14.184
Metabolism of RNA	R-HSA-8953854	9.425793e-14	13.026
Signaling by ROBO receptors	R-HSA-376176	7.793766e-13	12.108
Attenuation phase	R-HSA-3371568	7.556067e-12	11.122
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	1.243894e-11	10.905
HSF1-dependent transactivation	R-HSA-3371571	3.978395e-11	10.400
Eukaryotic Translation Elongation	R-HSA-156842	6.655987e-11	10.177
Cap-dependent Translation Initiation	R-HSA-72737	1.179992e-10	9.928
Eukaryotic Translation Initiation	R-HSA-72613	1.179992e-10	9.928
Cellular response to heat stress	R-HSA-3371556	1.094946e-10	9.961
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	1.331931e-10	9.876
Interleukin-12 signaling	R-HSA-9020591	3.906822e-10	9.408
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	4.548215e-10	9.342
Cell Cycle Checkpoints	R-HSA-69620	9.269161e-10	9.033
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	1.033921e-09	8.986
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	1.197714e-09	8.922
Mitotic Anaphase	R-HSA-68882	1.292151e-09	8.889
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.500966e-09	8.824
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	2.339336e-09	8.631
Nucleosome assembly	R-HSA-774815	2.339336e-09	8.631
Formation of a pool of free 40S subunits	R-HSA-72689	2.344833e-09	8.630
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	2.464081e-09	8.608
Mitotic Prophase	R-HSA-68875	2.901510e-09	8.537
Peptide chain elongation	R-HSA-156902	3.269431e-09	8.486
HDACs deacetylate histones	R-HSA-3214815	3.387842e-09	8.470
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	3.798160e-09	8.420
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	3.926295e-09	8.406
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	5.669118e-09	8.246
Meiotic synapsis	R-HSA-1221632	7.689646e-09	8.114
Interleukin-12 family signaling	R-HSA-447115	8.979725e-09	8.047
Nonsense-Mediated Decay (NMD)	R-HSA-927802	1.130007e-08	7.947
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	1.130007e-08	7.947
Separation of Sister Chromatids	R-HSA-2467813	1.087115e-08	7.964
rRNA processing in the nucleus and cytosol	R-HSA-8868773	1.165315e-08	7.934
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	1.195684e-08	7.922
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	1.259729e-08	7.900
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.636074e-08	7.786
Ribosome-associated quality control	R-HSA-9948299	1.763125e-08	7.754
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	1.728554e-08	7.762
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	1.902486e-08	7.721
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	2.092708e-08	7.679
Chromatin organization	R-HSA-4839726	2.112815e-08	7.675
Regulation of CDH1 Expression and Function	R-HSA-9764265	2.015579e-08	7.696
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	2.015579e-08	7.696
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	2.708850e-08	7.567
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	3.182968e-08	7.497
HSF1 activation	R-HSA-3371511	3.180962e-08	7.497
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	3.215719e-08	7.493
Estrogen-dependent gene expression	R-HSA-9018519	3.482424e-08	7.458
Oxidative Stress Induced Senescence	R-HSA-2559580	3.587986e-08	7.445
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	3.913234e-08	7.407
Influenza Infection	R-HSA-168255	4.983915e-08	7.302
Mitotic Prometaphase	R-HSA-68877	6.047000e-08	7.218
Apoptotic execution phase	R-HSA-75153	6.562599e-08	7.183
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	7.434235e-08	7.129
Packaging Of Telomere Ends	R-HSA-171306	8.149281e-08	7.089
RNA Polymerase I Promoter Opening	R-HSA-73728	8.149281e-08	7.089
Chromatin modifying enzymes	R-HSA-3247509	8.955593e-08	7.048
Cell-Cell communication	R-HSA-1500931	9.364884e-08	7.028
Transcriptional regulation by small RNAs	R-HSA-5578749	9.846379e-08	7.007
Inhibition of DNA recombination at telomere	R-HSA-9670095	1.296461e-07	6.887
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	1.331110e-07	6.876
Cellular Senescence	R-HSA-2559583	1.431175e-07	6.844
PRC2 methylates histones and DNA	R-HSA-212300	1.507519e-07	6.822
Translation initiation complex formation	R-HSA-72649	1.709181e-07	6.767
DNA Replication Pre-Initiation	R-HSA-69002	1.719857e-07	6.765
DNA methylation	R-HSA-5334118	1.840418e-07	6.735
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	2.194667e-07	6.659
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	2.258121e-07	6.646
Eukaryotic Translation Termination	R-HSA-72764	2.565670e-07	6.591
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	2.594327e-07	6.586
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	2.830280e-07	6.548
Ribosomal scanning and start codon recognition	R-HSA-72702	2.940459e-07	6.532
Influenza Viral RNA Transcription and Replication	R-HSA-168273	3.211488e-07	6.493
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	3.470892e-07	6.460
Assembly of the pre-replicative complex	R-HSA-68867	4.314294e-07	6.365
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	4.567701e-07	6.340
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	4.946725e-07	6.306
HATs acetylate histones	R-HSA-3214847	5.541781e-07	6.256
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	5.639661e-07	6.249
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	6.365124e-07	6.196
Cell junction organization	R-HSA-446728	6.180301e-07	6.209
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	7.649569e-07	6.116
Assembly of the ORC complex at the origin of replication	R-HSA-68616	7.994353e-07	6.097
Selenocysteine synthesis	R-HSA-2408557	8.019464e-07	6.096
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	8.303314e-07	6.081
SIRT1 negatively regulates rRNA expression	R-HSA-427359	9.363109e-07	6.029
Chaperone Mediated Autophagy	R-HSA-9613829	9.676745e-07	6.014
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	1.130693e-06	5.947
Viral mRNA Translation	R-HSA-192823	1.149131e-06	5.940
DNA Double Strand Break Response	R-HSA-5693606	1.229055e-06	5.910
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	1.554395e-06	5.808
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	1.554395e-06	5.808
Meiosis	R-HSA-1500620	1.686309e-06	5.773
Adherens junctions interactions	R-HSA-418990	1.651812e-06	5.782
G2/M Checkpoints	R-HSA-69481	2.146396e-06	5.668
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	2.354871e-06	5.628
Signal Transduction	R-HSA-162582	2.579974e-06	5.588
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	2.608444e-06	5.584
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	2.836894e-06	5.547
Homology Directed Repair	R-HSA-5693538	3.091805e-06	5.510
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	3.093091e-06	5.510
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	3.158176e-06	5.501
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	3.394657e-06	5.469
rRNA processing	R-HSA-72312	3.641299e-06	5.439
Condensation of Prophase Chromosomes	R-HSA-2299718	4.103710e-06	5.387
Transcriptional regulation by RUNX1	R-HSA-8878171	4.028687e-06	5.395
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	4.103710e-06	5.387
Cleavage of the damaged purine	R-HSA-110331	3.911756e-06	5.408
Ub-specific processing proteases	R-HSA-5689880	4.202440e-06	5.376
Transcriptional regulation of granulopoiesis	R-HSA-9616222	4.426814e-06	5.354
Apoptosis	R-HSA-109581	4.910333e-06	5.309
Depurination	R-HSA-73927	5.225570e-06	5.282
Recycling pathway of L1	R-HSA-437239	5.299551e-06	5.276
Amplification of signal from the kinetochores	R-HSA-141424	6.035106e-06	5.219
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	6.035106e-06	5.219
ESR-mediated signaling	R-HSA-8939211	6.162277e-06	5.210
TCF dependent signaling in response to WNT	R-HSA-201681	6.260869e-06	5.203
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	6.265607e-06	5.203
Defective pyroptosis	R-HSA-9710421	6.975042e-06	5.156
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	7.498168e-06	5.125
RNA Polymerase I Promoter Clearance	R-HSA-73854	8.025138e-06	5.096
DNA Double-Strand Break Repair	R-HSA-5693532	8.364037e-06	5.078
Aggrephagy	R-HSA-9646399	9.097491e-06	5.041
Kinesins	R-HSA-983189	9.347317e-06	5.029
mRNA Splicing - Major Pathway	R-HSA-72163	1.012639e-05	4.995
Diseases of programmed cell death	R-HSA-9645723	1.030695e-05	4.987
RNA Polymerase I Transcription	R-HSA-73864	1.170589e-05	4.932
Chromosome Maintenance	R-HSA-73886	1.228229e-05	4.911
Golgi-to-ER retrograde transport	R-HSA-8856688	1.259243e-05	4.900
HCMV Early Events	R-HSA-9609690	1.263526e-05	4.898
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.426091e-05	4.846
Meiotic recombination	R-HSA-912446	1.387661e-05	4.858
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.478215e-05	4.830
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.478215e-05	4.830
Signaling downstream of RAS mutants	R-HSA-9649948	1.478215e-05	4.830
Signaling by RAS mutants	R-HSA-6802949	1.478215e-05	4.830
L1CAM interactions	R-HSA-373760	1.488917e-05	4.827
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.545740e-05	4.811
mRNA Splicing	R-HSA-72172	1.578174e-05	4.802
Regulation of CDH1 Function	R-HSA-9764561	1.586990e-05	4.799
mRNA 3'-end processing	R-HSA-72187	1.740566e-05	4.759
RNA Polymerase I Promoter Escape	R-HSA-73772	1.740566e-05	4.759
DNA Replication	R-HSA-69306	1.913120e-05	4.718
Gene Silencing by RNA	R-HSA-211000	1.879276e-05	4.726
Cleavage of the damaged pyrimidine	R-HSA-110329	1.974587e-05	4.705
Depyrimidination	R-HSA-73928	1.974587e-05	4.705
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	1.994231e-05	4.700
Processing of DNA double-strand break ends	R-HSA-5693607	2.013322e-05	4.696
Amyloid fiber formation	R-HSA-977225	2.013322e-05	4.696
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	2.364222e-05	4.626
Cell-cell junction organization	R-HSA-421270	2.433353e-05	4.614
NoRC negatively regulates rRNA expression	R-HSA-427413	2.735322e-05	4.563
Metalloprotease DUBs	R-HSA-5689901	3.119528e-05	4.506
Deubiquitination	R-HSA-5688426	3.512208e-05	4.454
Mitotic Spindle Checkpoint	R-HSA-69618	3.691025e-05	4.433
Oncogenic MAPK signaling	R-HSA-6802957	3.978954e-05	4.400
Apoptotic cleavage of cellular proteins	R-HSA-111465	4.472208e-05	4.349
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	4.470712e-05	4.350
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	4.589197e-05	4.338
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	4.724006e-05	4.326
Regulation of endogenous retroelements	R-HSA-9842860	4.955685e-05	4.305
MAP2K and MAPK activation	R-HSA-5674135	5.463044e-05	4.263
Signaling by RAF1 mutants	R-HSA-9656223	5.463044e-05	4.263
Developmental Biology	R-HSA-1266738	6.293507e-05	4.201
Apoptosis induced DNA fragmentation	R-HSA-140342	6.478184e-05	4.189
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	6.573640e-05	4.182
Cellular response to starvation	R-HSA-9711097	7.504925e-05	4.125
MAPK family signaling cascades	R-HSA-5683057	7.685627e-05	4.114
Signaling by Interleukins	R-HSA-449147	7.960796e-05	4.099
G2/M Transition	R-HSA-69275	8.354085e-05	4.078
Developmental Lineages of the Mammary Gland	R-HSA-9924644	9.293402e-05	4.032
MAPK6/MAPK4 signaling	R-HSA-5687128	1.056702e-04	3.976
Mitotic G2-G2/M phases	R-HSA-453274	1.019543e-04	3.992
SARS-CoV-1-host interactions	R-HSA-9692914	9.985212e-05	4.001
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.032776e-04	3.986
RNA Polymerase II Transcription Termination	R-HSA-73856	1.076728e-04	3.968
Membrane Trafficking	R-HSA-199991	1.131437e-04	3.946
Epigenetic regulation of gene expression	R-HSA-212165	1.257848e-04	3.900
Telomere Maintenance	R-HSA-157579	1.488766e-04	3.827
Cell-extracellular matrix interactions	R-HSA-446353	1.646751e-04	3.783
Post NMDA receptor activation events	R-HSA-438064	1.658856e-04	3.780
Regulation of PD-L1(CD274) expression	R-HSA-9909648	1.731920e-04	3.761
UCH proteinases	R-HSA-5689603	1.786495e-04	3.748
Maternal to zygotic transition (MZT)	R-HSA-9816359	2.060845e-04	3.686
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	2.169163e-04	3.664
Hedgehog 'off' state	R-HSA-5610787	2.232308e-04	3.651
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	2.265380e-04	3.645
Host Interactions of HIV factors	R-HSA-162909	2.317113e-04	3.635
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	2.410790e-04	3.618
Regulation of T cell activation by CD28 family	R-HSA-388841	2.516568e-04	3.599
Programmed Cell Death	R-HSA-5357801	2.775224e-04	3.557
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	2.535898e-04	3.596
Viral Infection Pathways	R-HSA-9824446	2.628731e-04	3.580
Base Excision Repair	R-HSA-73884	2.546932e-04	3.594
Base-Excision Repair, AP Site Formation	R-HSA-73929	2.535898e-04	3.596
Intracellular signaling by second messengers	R-HSA-9006925	2.794083e-04	3.554
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	2.904989e-04	3.537
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	2.937798e-04	3.532
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	2.941494e-04	3.531
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	3.026546e-04	3.519
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	3.125241e-04	3.505
DNA Repair	R-HSA-73894	3.257071e-04	3.487
Signaling by WNT	R-HSA-195721	3.355584e-04	3.474
G2/M DNA damage checkpoint	R-HSA-69473	3.423549e-04	3.466
Signaling by EGFR	R-HSA-177929	3.621393e-04	3.441
EPH-Ephrin signaling	R-HSA-2682334	3.829707e-04	3.417
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	3.909623e-04	3.408
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	4.070561e-04	3.390
DAG and IP3 signaling	R-HSA-1489509	4.130724e-04	3.384
Nuclear Envelope Breakdown	R-HSA-2980766	4.300753e-04	3.366
p75 NTR receptor-mediated signalling	R-HSA-193704	4.586660e-04	3.339
Selective autophagy	R-HSA-9663891	4.695857e-04	3.328
HIV Infection	R-HSA-162906	5.024129e-04	3.299
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	5.050418e-04	3.297
Degradation of GLI1 by the proteasome	R-HSA-5610780	5.782402e-04	3.238
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	5.782402e-04	3.238
Calmodulin induced events	R-HSA-111933	5.367214e-04	3.270
CaM pathway	R-HSA-111997	5.367214e-04	3.270
Reproduction	R-HSA-1474165	5.616472e-04	3.251
Ca-dependent events	R-HSA-111996	7.008479e-04	3.154
Signaling by ERBB2	R-HSA-1227986	7.037118e-04	3.153
COPI-mediated anterograde transport	R-HSA-6807878	7.239578e-04	3.140
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	7.494645e-04	3.125
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	7.494645e-04	3.125
Translation	R-HSA-72766	7.548259e-04	3.122
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	7.823067e-04	3.107
FLT3 signaling by CBL mutants	R-HSA-9706377	7.921427e-04	3.101
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	8.080946e-04	3.093
Rap1 signalling	R-HSA-392517	8.690116e-04	3.061
HCMV Infection	R-HSA-9609646	9.032657e-04	3.044
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	9.340749e-04	3.030
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	9.762785e-04	3.010
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	9.843496e-04	3.007
EPHB-mediated forward signaling	R-HSA-3928662	1.012821e-03	2.994
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	1.111062e-03	2.954
Semaphorin interactions	R-HSA-373755	1.114421e-03	2.953
Selenoamino acid metabolism	R-HSA-2408522	1.119392e-03	2.951
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.189896e-03	2.924
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	1.293774e-03	2.888
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	1.293774e-03	2.888
Downregulation of ERBB2 signaling	R-HSA-8863795	1.280544e-03	2.893
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	1.293774e-03	2.888
p75NTR recruits signalling complexes	R-HSA-209543	1.347487e-03	2.870
HIV Life Cycle	R-HSA-162587	1.155344e-03	2.937
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	1.406135e-03	2.852
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	1.456756e-03	2.837
Processing of Intronless Pre-mRNAs	R-HSA-77595	1.498912e-03	2.824
RAF/MAP kinase cascade	R-HSA-5673001	1.524023e-03	2.817
EGFR downregulation	R-HSA-182971	1.583872e-03	2.800
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	1.583872e-03	2.800
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	1.583872e-03	2.800
Smooth Muscle Contraction	R-HSA-445355	1.645734e-03	2.784
Degradation of GLI2 by the proteasome	R-HSA-5610783	1.709056e-03	2.767
Negative regulation of MAPK pathway	R-HSA-5675221	1.709056e-03	2.767
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	1.812663e-03	2.742
Listeria monocytogenes entry into host cells	R-HSA-8876384	1.929859e-03	2.714
Co-inhibition by PD-1	R-HSA-389948	1.959537e-03	2.708
Activation of HOX genes during differentiation	R-HSA-5619507	2.016813e-03	2.695
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	2.016813e-03	2.695
PLC beta mediated events	R-HSA-112043	2.102048e-03	2.677
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	2.250071e-03	2.648
Signaling by NOTCH	R-HSA-157118	2.292925e-03	2.640
DNA Damage Bypass	R-HSA-73893	2.332524e-03	2.632
ISG15 antiviral mechanism	R-HSA-1169408	2.354087e-03	2.628
MAPK1/MAPK3 signaling	R-HSA-5684996	2.357031e-03	2.628
Clathrin-mediated endocytosis	R-HSA-8856828	2.361326e-03	2.627
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	2.476433e-03	2.606
Ephrin signaling	R-HSA-3928664	2.611653e-03	2.583
RMTs methylate histone arginines	R-HSA-3214858	2.827758e-03	2.549
DNA Damage Recognition in GG-NER	R-HSA-5696394	2.862170e-03	2.543
Striated Muscle Contraction	R-HSA-390522	2.862170e-03	2.543
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	3.229108e-03	2.491
Regulation of signaling by CBL	R-HSA-912631	3.368248e-03	2.473
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	3.084349e-03	2.511
Termination of translesion DNA synthesis	R-HSA-5656169	3.342826e-03	2.476
Late endosomal microautophagy	R-HSA-9615710	3.342826e-03	2.476
RAF activation	R-HSA-5673000	3.437545e-03	2.464
Dual Incision in GG-NER	R-HSA-5696400	3.437545e-03	2.464
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	3.071839e-03	2.513
Nuclear import of Rev protein	R-HSA-180746	3.437545e-03	2.464
Interactions of Rev with host cellular proteins	R-HSA-177243	3.414915e-03	2.467
G alpha (12/13) signalling events	R-HSA-416482	3.392410e-03	2.469
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	3.437545e-03	2.464
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	3.071839e-03	2.513
SARS-CoV-2-host interactions	R-HSA-9705683	2.942305e-03	2.531
Cytokine Signaling in Immune system	R-HSA-1280215	3.023367e-03	2.520
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	3.476803e-03	2.459
Sema3A PAK dependent Axon repulsion	R-HSA-399954	3.476803e-03	2.459
p75NTR signals via NF-kB	R-HSA-193639	3.476803e-03	2.459
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	3.476803e-03	2.459
Spry regulation of FGF signaling	R-HSA-1295596	3.476803e-03	2.459
VEGFA-VEGFR2 Pathway	R-HSA-4420097	3.610585e-03	2.442
Autophagy	R-HSA-9612973	3.731201e-03	2.428
CD209 (DC-SIGN) signaling	R-HSA-5621575	3.836308e-03	2.416
MHC class II antigen presentation	R-HSA-2132295	3.844990e-03	2.415
Regulation of Apoptosis	R-HSA-169911	4.102030e-03	2.387
Signaling by Nuclear Receptors	R-HSA-9006931	4.104661e-03	2.387
Signaling by MET	R-HSA-6806834	4.276434e-03	2.369
Negative regulation of MET activity	R-HSA-6807004	4.284638e-03	2.368
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	4.296512e-03	2.367
NF-kB is activated and signals survival	R-HSA-209560	4.494911e-03	2.347
G-protein mediated events	R-HSA-112040	4.633264e-03	2.334
RET signaling	R-HSA-8853659	4.864983e-03	2.313
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	5.381708e-03	2.269
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	5.381708e-03	2.269
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	5.381708e-03	2.269
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	5.480514e-03	2.261
Downregulation of ERBB4 signaling	R-HSA-1253288	5.480514e-03	2.261
ROBO receptors bind AKAP5	R-HSA-9010642	5.480514e-03	2.261
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	5.523684e-03	2.258
Degradation of DVL	R-HSA-4641258	5.736155e-03	2.241
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	5.736155e-03	2.241
Death Receptor Signaling	R-HSA-73887	5.771594e-03	2.239
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	5.914614e-03	2.228
Degradation of CDH1	R-HSA-9766229	5.966899e-03	2.224
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	6.093054e-03	2.215
Nuclear events mediated by NFE2L2	R-HSA-9759194	6.181486e-03	2.209
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	7.809978e-03	2.107
Interaction between L1 and Ankyrins	R-HSA-445095	6.973988e-03	2.157
Transport of the SLBP independent Mature mRNA	R-HSA-159227	6.950453e-03	2.158
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	6.296073e-03	2.201
Degradation of beta-catenin by the destruction complex	R-HSA-195253	6.617585e-03	2.179
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	7.809978e-03	2.107
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	6.725651e-03	2.172
Opioid Signalling	R-HSA-111885	7.524606e-03	2.124
Late Phase of HIV Life Cycle	R-HSA-162599	7.441057e-03	2.128
Macroautophagy	R-HSA-1632852	6.375135e-03	2.196
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	7.528327e-03	2.123
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	7.371046e-03	2.132
Pre-NOTCH Transcription and Translation	R-HSA-1912408	7.217089e-03	2.142
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	7.843876e-03	2.105
NS1 Mediated Effects on Host Pathways	R-HSA-168276	7.843876e-03	2.105
Stabilization of p53	R-HSA-69541	7.843876e-03	2.105
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	7.978387e-03	2.098
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	7.978387e-03	2.098
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	7.978387e-03	2.098
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	7.978387e-03	2.098
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	7.978387e-03	2.098
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	7.978387e-03	2.098
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	7.978387e-03	2.098
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	7.978387e-03	2.098
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	7.978387e-03	2.098
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	7.978387e-03	2.098
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	7.978387e-03	2.098
Muscle contraction	R-HSA-397014	8.129508e-03	2.090
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	8.204798e-03	2.086
Vpu mediated degradation of CD4	R-HSA-180534	8.204798e-03	2.086
Cellular response to hypoxia	R-HSA-1234174	8.245938e-03	2.084
Activation of AMPK downstream of NMDARs	R-HSA-9619483	8.367910e-03	2.077
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	8.479511e-03	2.072
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	8.479511e-03	2.072
Regulation of TP53 Activity	R-HSA-5633007	8.943311e-03	2.049
Nucleotide Excision Repair	R-HSA-5696398	9.001461e-03	2.046
Regulation of RUNX3 expression and activity	R-HSA-8941858	9.101482e-03	2.041
Signaling by Hedgehog	R-HSA-5358351	9.121212e-03	2.040
SARS-CoV-1 Infection	R-HSA-9678108	9.122153e-03	2.040
Maturation of protein E	R-HSA-9683683	9.148611e-03	2.039
Maturation of protein E	R-HSA-9694493	9.148611e-03	2.039
Signaling by VEGF	R-HSA-194138	9.339639e-03	2.030
Depolymerization of the Nuclear Lamina	R-HSA-4419969	9.446142e-03	2.025
Transport of connexons to the plasma membrane	R-HSA-190872	9.446142e-03	2.025
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	9.626224e-03	2.017
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.001504e-02	1.999
Glycolysis	R-HSA-70171	1.020653e-02	1.991
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.046853e-02	1.980
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	1.046853e-02	1.980
NRIF signals cell death from the nucleus	R-HSA-205043	1.046853e-02	1.980
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	1.046853e-02	1.980
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	1.050931e-02	1.978
PKMTs methylate histone lysines	R-HSA-3214841	1.050931e-02	1.978
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	1.050931e-02	1.978
FLT3 Signaling	R-HSA-9607240	1.050931e-02	1.978
MET activates RAP1 and RAC1	R-HSA-8875555	1.075101e-02	1.969
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	1.075101e-02	1.969
Josephin domain DUBs	R-HSA-5689877	1.075101e-02	1.969
Pexophagy	R-HSA-9664873	1.075101e-02	1.969
Signaling by APC mutants	R-HSA-4839744	1.437032e-02	1.843
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.437032e-02	1.843
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.437032e-02	1.843
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.437032e-02	1.843
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	1.333426e-02	1.875
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.333426e-02	1.875
Co-inhibition by CTLA4	R-HSA-389513	1.431524e-02	1.844
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	1.201357e-02	1.920
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.122816e-02	1.950
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	1.139698e-02	1.943
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.431524e-02	1.844
ATP-dependent chromatin remodelers	R-HSA-9932444	1.434318e-02	1.843
SWI/SNF chromatin remodelers	R-HSA-9932451	1.434318e-02	1.843
KEAP1-NFE2L2 pathway	R-HSA-9755511	1.420699e-02	1.847
Post-chaperonin tubulin folding pathway	R-HSA-389977	1.431524e-02	1.844
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	1.122816e-02	1.950
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	1.122816e-02	1.950
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	1.426410e-02	1.846
p53-Dependent G1 DNA Damage Response	R-HSA-69563	1.426410e-02	1.846
Interleukin-1 signaling	R-HSA-9020702	1.114874e-02	1.953
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.207833e-02	1.918
tRNA processing in the nucleus	R-HSA-6784531	1.291650e-02	1.889
Vif-mediated degradation of APOBEC3G	R-HSA-180585	1.302413e-02	1.885
MAP kinase activation	R-HSA-450294	1.154441e-02	1.938
HCMV Late Events	R-HSA-9610379	1.249806e-02	1.903
Gap junction trafficking and regulation	R-HSA-157858	1.426410e-02	1.846
FLT3 signaling in disease	R-HSA-9682385	1.302413e-02	1.885
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	1.437032e-02	1.843
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	1.381958e-02	1.860
G1/S DNA Damage Checkpoints	R-HSA-69615	1.441158e-02	1.841
MET interacts with TNS proteins	R-HSA-8875513	1.448085e-02	1.839
Vpr-mediated nuclear import of PICs	R-HSA-180910	1.502759e-02	1.823
Degradation of AXIN	R-HSA-4641257	1.502759e-02	1.823
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	1.502759e-02	1.823
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.536304e-02	1.814
PCP/CE pathway	R-HSA-4086400	1.536304e-02	1.814
Regulation of RAS by GAPs	R-HSA-5658442	1.609371e-02	1.793
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	1.670752e-02	1.777
Vesicle-mediated transport	R-HSA-5653656	1.687540e-02	1.773
Signaling by EGFR in Cancer	R-HSA-1643713	1.698504e-02	1.770
MET promotes cell motility	R-HSA-8875878	1.725193e-02	1.763
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.761064e-02	1.754
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.761064e-02	1.754
Diseases of Telomere Maintenance	R-HSA-9673013	1.761064e-02	1.754
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.761064e-02	1.754
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.761064e-02	1.754
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	1.786275e-02	1.748
Dual incision in TC-NER	R-HSA-6782135	1.804832e-02	1.744
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	1.809508e-02	1.742
PKR-mediated signaling	R-HSA-9833482	1.855028e-02	1.732
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	1.872764e-02	1.728
Signaling by GSK3beta mutants	R-HSA-5339716	1.872764e-02	1.728
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	1.872764e-02	1.728
Signaling by AMER1 mutants	R-HSA-4839748	1.872764e-02	1.728
Signaling by AXIN mutants	R-HSA-4839735	1.872764e-02	1.728
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	1.912939e-02	1.718
Regulation of PTEN localization	R-HSA-8948747	1.912939e-02	1.718
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.917463e-02	1.717
Chaperonin-mediated protein folding	R-HSA-390466	1.950742e-02	1.710
AURKA Activation by TPX2	R-HSA-8854518	1.970237e-02	1.705
Regulation of TP53 Expression and Degradation	R-HSA-6806003	1.971027e-02	1.705
Transcriptional Regulation by E2F6	R-HSA-8953750	1.971027e-02	1.705
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.984169e-02	1.702
Signaling by ALK in cancer	R-HSA-9700206	1.984169e-02	1.702
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.995993e-02	1.700
PIP3 activates AKT signaling	R-HSA-1257604	2.006500e-02	1.698
Defective CFTR causes cystic fibrosis	R-HSA-5678895	2.018643e-02	1.695
Asymmetric localization of PCP proteins	R-HSA-4608870	2.018643e-02	1.695
Orc1 removal from chromatin	R-HSA-68949	2.027732e-02	1.693
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	2.075504e-02	1.683
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.078286e-02	1.682
Formation of Incision Complex in GG-NER	R-HSA-5696395	2.241544e-02	1.649
Interactions of Vpr with host cellular proteins	R-HSA-176033	2.241544e-02	1.649
Negative regulation of NOTCH4 signaling	R-HSA-9604323	2.241544e-02	1.649
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	2.264936e-02	1.645
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	2.272571e-02	1.643
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	2.272571e-02	1.643
Protein ubiquitination	R-HSA-8852135	2.313209e-02	1.636
Centrosome maturation	R-HSA-380287	2.313209e-02	1.636
Activation of NOXA and translocation to mitochondria	R-HSA-111448	2.326279e-02	1.633
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	2.387456e-02	1.622
IRAK1 recruits IKK complex	R-HSA-937039	2.387456e-02	1.622
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	2.387456e-02	1.622
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	2.387456e-02	1.622
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	2.387456e-02	1.622
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	2.387456e-02	1.622
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	2.387456e-02	1.622
VLDLR internalisation and degradation	R-HSA-8866427	2.387456e-02	1.622
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	2.463078e-02	1.609
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	2.472244e-02	1.607
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	2.472244e-02	1.607
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	2.512500e-02	1.600
Signaling by Hippo	R-HSA-2028269	2.512500e-02	1.600
Hh mutants are degraded by ERAD	R-HSA-5362768	2.537985e-02	1.596
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	2.537985e-02	1.596
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	2.549090e-02	1.594
Myoclonic epilepsy of Lafora	R-HSA-3785653	2.593144e-02	1.586
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	2.593144e-02	1.586
Modulation by Mtb of host immune system	R-HSA-9637628	2.593144e-02	1.586
Neutrophil degranulation	R-HSA-6798695	2.688182e-02	1.571
Co-stimulation by CD28	R-HSA-389356	2.849195e-02	1.545
Degradation of CRY and PER proteins	R-HSA-9932298	2.861537e-02	1.543
Interleukin-17 signaling	R-HSA-448424	2.888578e-02	1.539
Membrane binding and targetting of GAG proteins	R-HSA-174490	2.985376e-02	1.525
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	3.001153e-02	1.523
Loss of Nlp from mitotic centrosomes	R-HSA-380259	3.001153e-02	1.523
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	3.001153e-02	1.523
Signaling by PTK6	R-HSA-8848021	3.001153e-02	1.523
Platelet sensitization by LDL	R-HSA-432142	3.023383e-02	1.520
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	3.023383e-02	1.520
Pre-NOTCH Expression and Processing	R-HSA-1912422	3.083364e-02	1.511
NRAGE signals death through JNK	R-HSA-193648	3.099065e-02	1.509
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	3.107528e-02	1.508
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	3.117536e-02	1.506
Hedgehog 'on' state	R-HSA-5632684	3.160494e-02	1.500
Cargo trafficking to the periciliary membrane	R-HSA-5620920	3.160494e-02	1.500
Inhibition of Host mRNA Processing and RNA Silencing	R-HSA-168315	3.711661e-02	1.430
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	3.435616e-02	1.464
Negative feedback regulation of MAPK pathway	R-HSA-5674499	4.771598e-02	1.321
Folding of actin by CCT/TriC	R-HSA-390450	4.340634e-02	1.362
Regulation of KIT signaling	R-HSA-1433559	3.669844e-02	1.435
Beta-catenin phosphorylation cascade	R-HSA-196299	4.443215e-02	1.352
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	4.443215e-02	1.352
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	4.237998e-02	1.373
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	3.556831e-02	1.449
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	3.556831e-02	1.449
Integrin signaling	R-HSA-354192	4.582359e-02	1.339
G-protein beta:gamma signalling	R-HSA-397795	4.582359e-02	1.339
IPs transport between nucleus and cytosol	R-HSA-1855170	4.582359e-02	1.339
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	4.448381e-02	1.352
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	4.303818e-02	1.366
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	4.303818e-02	1.366
Formation of RNA Pol II elongation complex	R-HSA-112382	4.303818e-02	1.366
RNA Polymerase II Transcription Elongation	R-HSA-75955	4.735127e-02	1.325
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	4.735127e-02	1.325
Metabolism of non-coding RNA	R-HSA-194441	4.133835e-02	1.384
snRNP Assembly	R-HSA-191859	4.133835e-02	1.384
Sema4D in semaphorin signaling	R-HSA-400685	3.915285e-02	1.407
VxPx cargo-targeting to cilium	R-HSA-5620916	4.237998e-02	1.373
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	4.501914e-02	1.347
Translesion Synthesis by POLH	R-HSA-110320	3.597853e-02	1.444
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	3.381012e-02	1.471
Neurodegenerative Diseases	R-HSA-8863678	3.381012e-02	1.471
Protein folding	R-HSA-391251	3.192635e-02	1.496
DCC mediated attractive signaling	R-HSA-418885	4.443215e-02	1.352
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	3.669844e-02	1.435
Translesion synthesis by REV1	R-HSA-110312	4.443215e-02	1.352
Nuclear RNA decay	R-HSA-9930044	4.582359e-02	1.339
RNA Polymerase II Pre-transcription Events	R-HSA-674695	4.087453e-02	1.389
Signal transduction by L1	R-HSA-445144	4.237998e-02	1.373
Breakdown of the nuclear lamina	R-HSA-352238	3.711661e-02	1.430
Regulation of TP53 Degradation	R-HSA-6804757	3.199888e-02	1.495
HDR through Homologous Recombination (HRR)	R-HSA-5685942	4.308499e-02	1.366
Response of endothelial cells to shear stress	R-HSA-9860931	4.617868e-02	1.336
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	4.771598e-02	1.321
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	4.771598e-02	1.321
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	3.401519e-02	1.468
Regulation of PTEN stability and activity	R-HSA-8948751	4.735127e-02	1.325
Regulation of MECP2 expression and activity	R-HSA-9022692	4.582359e-02	1.339
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	3.779776e-02	1.423
Interleukin-1 family signaling	R-HSA-446652	4.093269e-02	1.388
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	4.443215e-02	1.352
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	3.556831e-02	1.449
Signaling by NTRKs	R-HSA-166520	3.250689e-02	1.488
Gap junction trafficking	R-HSA-190828	4.005811e-02	1.397
Glucose metabolism	R-HSA-70326	4.585417e-02	1.339
Hh mutants abrogate ligand secretion	R-HSA-5387390	3.594428e-02	1.444
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	4.448381e-02	1.352
Signaling by NOTCH4	R-HSA-9013694	4.087453e-02	1.389
XBP1(S) activates chaperone genes	R-HSA-381038	3.377912e-02	1.471
SARS-CoV-2 Infection	R-HSA-9694516	3.211721e-02	1.493
G1/S Transition	R-HSA-69206	4.833212e-02	1.316
ER to Golgi Anterograde Transport	R-HSA-199977	4.908076e-02	1.309
mRNA Splicing - Minor Pathway	R-HSA-72165	4.922947e-02	1.308
Transcriptional regulation by RUNX3	R-HSA-8878159	4.939042e-02	1.306
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	4.945405e-02	1.306
Early Phase of HIV Life Cycle	R-HSA-162594	4.945405e-02	1.306
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	5.160867e-02	1.287
S Phase	R-HSA-69242	5.181914e-02	1.286
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	5.187000e-02	1.285
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	5.187000e-02	1.285
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	5.194914e-02	1.284
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	5.268018e-02	1.278
IRE1alpha activates chaperones	R-HSA-381070	5.281644e-02	1.277
MyD88 cascade initiated on plasma membrane	R-HSA-975871	5.285113e-02	1.277
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	5.285113e-02	1.277
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	5.285113e-02	1.277
Translesion synthesis by POLI	R-HSA-5656121	5.306877e-02	1.275
Prolonged ERK activation events	R-HSA-169893	5.306877e-02	1.275
Regulation of NF-kappa B signaling	R-HSA-9758274	5.306877e-02	1.275
Negative regulation of FLT3	R-HSA-9706369	5.306877e-02	1.275
PECAM1 interactions	R-HSA-210990	5.410851e-02	1.267
ChREBP activates metabolic gene expression	R-HSA-163765	5.410851e-02	1.267
Cellular responses to mechanical stimuli	R-HSA-9855142	5.568450e-02	1.254
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	5.683763e-02	1.245
Signaling by PDGFR in disease	R-HSA-9671555	5.721149e-02	1.243
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	5.721149e-02	1.243
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	5.721149e-02	1.243
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	5.721149e-02	1.243
Assembly Of The HIV Virion	R-HSA-175474	5.721149e-02	1.243
Negative regulation of FGFR3 signaling	R-HSA-5654732	5.836903e-02	1.234
Gene expression (Transcription)	R-HSA-74160	5.840614e-02	1.234
rRNA modification in the nucleus and cytosol	R-HSA-6790901	5.857837e-02	1.232
Synthesis of DNA	R-HSA-69239	5.979947e-02	1.223
Regulation of TP53 Expression	R-HSA-6804754	6.184526e-02	1.209
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	6.184526e-02	1.209
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	6.191181e-02	1.208
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	6.191181e-02	1.208
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	6.202180e-02	1.207
Transcriptional Regulation by TP53	R-HSA-3700989	6.232015e-02	1.205
Translesion synthesis by POLK	R-HSA-5655862	6.261271e-02	1.203
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	6.261271e-02	1.203
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	6.261271e-02	1.203
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	6.261271e-02	1.203
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	6.323948e-02	1.199
PTK6 promotes HIF1A stabilization	R-HSA-8857538	6.323948e-02	1.199
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	6.359734e-02	1.197
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	6.444569e-02	1.191
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	6.453593e-02	1.190
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	6.453593e-02	1.190
Signalling to ERKs	R-HSA-187687	6.453593e-02	1.190
Signaling by FGFR2	R-HSA-5654738	6.487637e-02	1.188
FGFR2 alternative splicing	R-HSA-6803529	6.565793e-02	1.183
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	6.565793e-02	1.183
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	6.565793e-02	1.183
Signaling by CSF3 (G-CSF)	R-HSA-9674555	6.586821e-02	1.181
Negative regulation of FGFR4 signaling	R-HSA-5654733	6.586821e-02	1.181
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	6.610528e-02	1.180
Integration of provirus	R-HSA-162592	6.610528e-02	1.180
Mitotic Telophase/Cytokinesis	R-HSA-68884	6.610528e-02	1.180
Developmental Cell Lineages	R-HSA-9734767	6.655751e-02	1.177
MyD88 dependent cascade initiated on endosome	R-HSA-975155	6.755710e-02	1.170
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	6.874482e-02	1.163
MTOR signalling	R-HSA-165159	6.874482e-02	1.163
Switching of origins to a post-replicative state	R-HSA-69052	6.943310e-02	1.158
MyD88-independent TLR4 cascade	R-HSA-166166	7.168081e-02	1.145
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	7.168081e-02	1.145
PTEN Regulation	R-HSA-6807070	7.396746e-02	1.131
Unfolded Protein Response (UPR)	R-HSA-381119	7.396746e-02	1.131
ER-Phagosome pathway	R-HSA-1236974	7.422015e-02	1.129
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	7.479390e-02	1.126
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	7.479390e-02	1.126
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	7.553281e-02	1.122
Circadian clock	R-HSA-9909396	7.564307e-02	1.121
Activation of NF-kappaB in B cells	R-HSA-1169091	7.797017e-02	1.108
Hedgehog ligand biogenesis	R-HSA-5358346	7.797017e-02	1.108
SARS-CoV Infections	R-HSA-9679506	7.806056e-02	1.108
Ovarian tumor domain proteases	R-HSA-5689896	7.930461e-02	1.101
AKT phosphorylates targets in the cytosol	R-HSA-198323	7.936245e-02	1.100
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	7.936245e-02	1.100
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	7.936245e-02	1.100
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	7.936245e-02	1.100
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	7.936245e-02	1.100
Non-integrin membrane-ECM interactions	R-HSA-3000171	8.014829e-02	1.096
Cellular response to chemical stress	R-HSA-9711123	8.027688e-02	1.095
Cohesin Loading onto Chromatin	R-HSA-2470946	8.078190e-02	1.093
CHL1 interactions	R-HSA-447041	8.078190e-02	1.093
Uptake and function of diphtheria toxin	R-HSA-5336415	8.078190e-02	1.093
Cyclin D associated events in G1	R-HSA-69231	8.271758e-02	1.082
G1 Phase	R-HSA-69236	8.271758e-02	1.082
Signaling by TGF-beta Receptor Complex	R-HSA-170834	8.318786e-02	1.080
Signaling by ERBB2 ECD mutants	R-HSA-9665348	8.439523e-02	1.074
GAB1 signalosome	R-HSA-180292	8.439523e-02	1.074
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	8.439523e-02	1.074
PKA activation	R-HSA-163615	8.439523e-02	1.074
PKA activation in glucagon signalling	R-HSA-164378	8.439523e-02	1.074
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	8.439523e-02	1.074
Regulation of TP53 Activity through Methylation	R-HSA-6804760	8.439523e-02	1.074
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	8.505261e-02	1.070
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	9.016241e-02	1.045
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	9.062339e-02	1.043
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	9.062339e-02	1.043
Regulation of RUNX2 expression and activity	R-HSA-8939902	9.249579e-02	1.034
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	9.383033e-02	1.028
Frs2-mediated activation	R-HSA-170968	9.383033e-02	1.028
Drug resistance of KIT mutants	R-HSA-9669937	9.542946e-02	1.020
Drug resistance of PDGFR mutants	R-HSA-9674415	9.542946e-02	1.020
KIT mutants bind TKIs	R-HSA-9669921	9.542946e-02	1.020
PDGFR mutants bind TKIs	R-HSA-9674428	9.542946e-02	1.020
Sunitinib-resistant PDGFR mutants	R-HSA-9674401	9.542946e-02	1.020
Imatinib-resistant PDGFR mutants	R-HSA-9674396	9.542946e-02	1.020
Loss of Function of TP53 in Cancer	R-HSA-9723907	9.542946e-02	1.020
Regorafenib-resistant KIT mutants	R-HSA-9669929	9.542946e-02	1.020
Regorafenib-resistant PDGFR mutants	R-HSA-9674403	9.542946e-02	1.020
Nilotinib-resistant KIT mutants	R-HSA-9669926	9.542946e-02	1.020
Sunitinib-resistant KIT mutants	R-HSA-9669934	9.542946e-02	1.020
Imatinib-resistant KIT mutants	R-HSA-9669917	9.542946e-02	1.020
Masitinib-resistant KIT mutants	R-HSA-9669924	9.542946e-02	1.020
Sorafenib-resistant PDGFR mutants	R-HSA-9674404	9.542946e-02	1.020
Dasatinib-resistant KIT mutants	R-HSA-9669914	9.542946e-02	1.020
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	9.542946e-02	1.020
Sorafenib-resistant KIT mutants	R-HSA-9669936	9.542946e-02	1.020
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	9.542946e-02	1.020
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	9.592317e-02	1.018
IKK complex recruitment mediated by RIP1	R-HSA-937041	9.659939e-02	1.015
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	9.659939e-02	1.015
Integration of energy metabolism	R-HSA-163685	9.717771e-02	1.012
Beta-catenin independent WNT signaling	R-HSA-3858494	9.717771e-02	1.012
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	9.827690e-02	1.008
Cyclin E associated events during G1/S transition	R-HSA-69202	9.903672e-02	1.004
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	9.951257e-02	1.002
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.001692e-01	0.999
Formation of annular gap junctions	R-HSA-196025	1.001692e-01	0.999
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	1.001692e-01	0.999
Adrenoceptors	R-HSA-390696	1.001692e-01	0.999
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	1.013944e-01	0.994
Negative regulation of FGFR1 signaling	R-HSA-5654726	1.013944e-01	0.994
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	1.013944e-01	0.994
Regulation of mitotic cell cycle	R-HSA-453276	1.059193e-01	0.975
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	1.059193e-01	0.975
Myogenesis	R-HSA-525793	1.062713e-01	0.974
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	1.062713e-01	0.974
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	1.066473e-01	0.972
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	1.066473e-01	0.972
Signaling by NOTCH3	R-HSA-9012852	1.071618e-01	0.970
C-type lectin receptors (CLRs)	R-HSA-5621481	1.078999e-01	0.967
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	1.096433e-01	0.960
Nephrin family interactions	R-HSA-373753	1.096433e-01	0.960
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	1.116347e-01	0.952
Glucagon signaling in metabolic regulation	R-HSA-163359	1.116347e-01	0.952
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	1.130770e-01	0.947
TCR signaling	R-HSA-202403	1.137465e-01	0.944
VEGFR2 mediated vascular permeability	R-HSA-5218920	1.143662e-01	0.942
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	1.143662e-01	0.942
GPER1 signaling	R-HSA-9634597	1.154063e-01	0.938
Rab regulation of trafficking	R-HSA-9007101	1.163913e-01	0.934
Infectious disease	R-HSA-5663205	1.169000e-01	0.932
EPHA-mediated growth cone collapse	R-HSA-3928663	1.180749e-01	0.928
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	1.180749e-01	0.928
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	1.180749e-01	0.928
Insulin processing	R-HSA-264876	1.180749e-01	0.928
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	1.206189e-01	0.919
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	1.212088e-01	0.916
ARMS-mediated activation	R-HSA-170984	1.212088e-01	0.916
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	1.212088e-01	0.916
Gap junction degradation	R-HSA-190873	1.212088e-01	0.916
ALK mutants bind TKIs	R-HSA-9700645	1.212088e-01	0.916
GP1b-IX-V activation signalling	R-HSA-430116	1.212088e-01	0.916
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	1.817572e-01	0.741
Defective Mismatch Repair Associated With PMS2	R-HSA-5632987	1.817572e-01	0.741
TICAM1 deficiency - HSE	R-HSA-5602566	1.817572e-01	0.741
Defective Mismatch Repair Associated With MLH1	R-HSA-5545483	1.817572e-01	0.741
RPIA deficiency: failed conversion of R5P to RU5P	R-HSA-5659996	1.817572e-01	0.741
RPIA deficiency: failed conversion of RU5P to R5P	R-HSA-6791461	1.817572e-01	0.741
Defective ACTH causes obesity and POMCD	R-HSA-5579031	1.817572e-01	0.741
Regulation of gap junction activity	R-HSA-191650	1.224539e-01	0.912
PLCG1 events in ERBB2 signaling	R-HSA-1251932	1.224539e-01	0.912
Inhibition of TSC complex formation by PKB	R-HSA-165181	1.224539e-01	0.912
IRS activation	R-HSA-74713	1.564929e-01	0.806
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	1.564929e-01	0.806
Pentose phosphate pathway disease	R-HSA-6791465	1.920298e-01	0.717
Signalling to p38 via RIT and RIN	R-HSA-187706	1.920298e-01	0.717
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	1.920298e-01	0.717
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	1.920298e-01	0.717
Noncanonical activation of NOTCH3	R-HSA-9017802	1.920298e-01	0.717
PI3K/AKT activation	R-HSA-198203	1.436973e-01	0.843
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.436973e-01	0.843
2-LTR circle formation	R-HSA-164843	1.436973e-01	0.843
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	2.284690e-01	0.641
Erythropoietin activates STAT5	R-HSA-9027283	2.284690e-01	0.641
Autointegration results in viral DNA circles	R-HSA-177539	2.284690e-01	0.641
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	1.438196e-01	0.842
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	1.921949e-01	0.716
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	1.234921e-01	0.908
G beta:gamma signalling through CDC42	R-HSA-8964616	1.624066e-01	0.789
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	2.177982e-01	0.662
Signaling by EGFRvIII in Cancer	R-HSA-5637812	1.818047e-01	0.740
Constitutive Signaling by EGFRvIII	R-HSA-5637810	1.818047e-01	0.740
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	2.440460e-01	0.613
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	2.440460e-01	0.613
FOXO-mediated transcription of cell death genes	R-HSA-9614657	2.019181e-01	0.695
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	1.435243e-01	0.843
Signaling by ERBB2 in Cancer	R-HSA-1227990	1.571160e-01	0.804
SHC1 events in ERBB2 signaling	R-HSA-1250196	1.571160e-01	0.804
Deadenylation of mRNA	R-HSA-429947	1.860543e-01	0.730
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	2.226498e-01	0.652
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.297309e-01	0.887
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	2.398295e-01	0.620
Activation of the pre-replicative complex	R-HSA-68962	1.571160e-01	0.804
Platelet Aggregation (Plug Formation)	R-HSA-76009	1.680026e-01	0.775
PKA-mediated phosphorylation of CREB	R-HSA-111931	1.234921e-01	0.908
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	2.212045e-01	0.655
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.245481e-01	0.905
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	1.438196e-01	0.842
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	1.564929e-01	0.806
Regulation of CDH11 function	R-HSA-9762292	1.436973e-01	0.843
Negative regulation of the PI3K/AKT network	R-HSA-199418	2.127373e-01	0.672
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	1.564929e-01	0.806
mTORC1-mediated signalling	R-HSA-166208	1.534367e-01	0.814
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	1.834868e-01	0.736
Long-term potentiation	R-HSA-9620244	2.032317e-01	0.692
Fanconi Anemia Pathway	R-HSA-6783310	1.680026e-01	0.775
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	1.698533e-01	0.770
Platelet activation, signaling and aggregation	R-HSA-76002	1.329911e-01	0.876
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	2.226498e-01	0.652
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	1.382130e-01	0.859
Signaling by NOTCH1	R-HSA-1980143	2.279126e-01	0.642
Signaling by FLT3 fusion proteins	R-HSA-9703465	2.209123e-01	0.656
Aryl hydrocarbon receptor signalling	R-HSA-8937144	1.920298e-01	0.717
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	1.680026e-01	0.775
DARPP-32 events	R-HSA-180024	1.435243e-01	0.843
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	1.798587e-01	0.745
Negative regulation of FGFR2 signaling	R-HSA-5654727	1.223990e-01	0.912
Heme signaling	R-HSA-9707616	1.711416e-01	0.767
Cilium Assembly	R-HSA-5617833	1.586840e-01	0.799
RNA Polymerase II Transcription	R-HSA-73857	1.384699e-01	0.859
Regulation of PTEN gene transcription	R-HSA-8943724	1.512723e-01	0.820
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	1.920298e-01	0.717
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	1.438196e-01	0.842
Regulation of FZD by ubiquitination	R-HSA-4641263	1.818047e-01	0.740
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	2.019181e-01	0.695
NOD1/2 Signaling Pathway	R-HSA-168638	1.223990e-01	0.912
Viral Messenger RNA Synthesis	R-HSA-168325	1.610563e-01	0.793
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	2.209123e-01	0.656
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	1.576774e-01	0.802
Regulation of TNFR1 signaling	R-HSA-5357905	1.799158e-01	0.745
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	2.439028e-01	0.613
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	1.984896e-01	0.702
Organelle biogenesis and maintenance	R-HSA-1852241	1.738341e-01	0.760
NGF-stimulated transcription	R-HSA-9031628	2.047931e-01	0.689
Nef and signal transduction	R-HSA-164944	2.284690e-01	0.641
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	2.177982e-01	0.662
Disorders of Nervous System Development	R-HSA-9697154	2.177982e-01	0.662
Pervasive developmental disorders	R-HSA-9005895	2.177982e-01	0.662
Protein hydroxylation	R-HSA-9629569	2.439028e-01	0.613
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	2.009756e-01	0.697
CLEC7A (Dectin-1) signaling	R-HSA-5607764	1.263937e-01	0.898
Hemostasis	R-HSA-109582	1.865838e-01	0.729
TNF signaling	R-HSA-75893	1.984896e-01	0.702
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	1.858765e-01	0.731
Signaling by FGFR4	R-HSA-5654743	1.453167e-01	0.838
Platelet degranulation	R-HSA-114608	1.302166e-01	0.885
Signaling by FGFR1	R-HSA-5654736	1.984896e-01	0.702
Signaling by FGFR3	R-HSA-5654741	1.680026e-01	0.775
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	1.921750e-01	0.716
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	1.920298e-01	0.717
Integration of viral DNA into host genomic DNA	R-HSA-175567	2.284690e-01	0.641
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	1.858765e-01	0.731
Activation of ATR in response to replication stress	R-HSA-176187	2.009756e-01	0.697
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	2.390374e-01	0.622
Signaling by FGFR	R-HSA-190236	1.402970e-01	0.853
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	1.234921e-01	0.908
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	2.209123e-01	0.656
Mitophagy	R-HSA-5205647	1.223990e-01	0.912
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	1.541914e-01	0.812
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	1.479581e-01	0.830
Antigen processing-Cross presentation	R-HSA-1236975	2.304837e-01	0.637
Sodium-coupled phosphate cotransporters	R-HSA-427652	1.920298e-01	0.717
Activation of RAC1	R-HSA-428540	1.921949e-01	0.716
RAS processing	R-HSA-9648002	1.834868e-01	0.736
Transcriptional Regulation by MECP2	R-HSA-8986944	1.369918e-01	0.863
Signaling by ALK	R-HSA-201556	1.834868e-01	0.736
Regulation of CDH19 Expression and Function	R-HSA-9764302	1.920298e-01	0.717
NPAS4 regulates expression of target genes	R-HSA-9768919	2.324232e-01	0.634
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	1.664186e-01	0.779
Gap junction assembly	R-HSA-190861	1.223990e-01	0.912
CD28 dependent Vav1 pathway	R-HSA-389359	2.440460e-01	0.613
Regulation of BACH1 activity	R-HSA-9708530	1.438196e-01	0.842
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	1.984896e-01	0.702
Glycogen storage diseases	R-HSA-3229121	1.818047e-01	0.740
Glycogen synthesis	R-HSA-3322077	2.439028e-01	0.613
RAB geranylgeranylation	R-HSA-8873719	2.474242e-01	0.607
Oncogene Induced Senescence	R-HSA-2559585	2.486929e-01	0.604
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	2.492276e-01	0.603
ABC transporter disorders	R-HSA-5619084	2.501805e-01	0.602
Signaling by SCF-KIT	R-HSA-1433557	2.545910e-01	0.594
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	2.575478e-01	0.589
Signaling by juxtamembrane domain KIT mutants	R-HSA-9669935	2.598509e-01	0.585
Signaling by extracellular domain mutants of KIT	R-HSA-9680187	2.598509e-01	0.585
Signaling by kinase domain mutants of KIT	R-HSA-9669933	2.598509e-01	0.585
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.598509e-01	0.585
Defective MMADHC causes MMAHCD	R-HSA-3359473	2.598509e-01	0.585
Defective SLC26A2 causes chondrodysplasias	R-HSA-3560792	2.598509e-01	0.585
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	2.598509e-01	0.585
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5619081	2.598509e-01	0.585
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.598509e-01	0.585
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	2.598509e-01	0.585
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	2.598509e-01	0.585
TRAF3 deficiency - HSE	R-HSA-5602571	2.598509e-01	0.585
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5660724	2.598509e-01	0.585
Nef mediated downregulation of CD28 cell surface expression	R-HSA-164939	2.598509e-01	0.585
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	2.598509e-01	0.585
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	2.612963e-01	0.583
Sensory processing of sound	R-HSA-9659379	2.615946e-01	0.582
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	2.653152e-01	0.576
SOS-mediated signalling	R-HSA-112412	2.653152e-01	0.576
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	2.653152e-01	0.576
Activated NTRK3 signals through PI3K	R-HSA-9603381	2.653152e-01	0.576
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	2.653152e-01	0.576
ERK/MAPK targets	R-HSA-198753	2.655812e-01	0.576
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	2.655812e-01	0.576
Transcriptional regulation by RUNX2	R-HSA-8878166	2.664725e-01	0.574
CRMPs in Sema3A signaling	R-HSA-399956	2.707570e-01	0.567
Signal regulatory protein family interactions	R-HSA-391160	2.707570e-01	0.567
HDL assembly	R-HSA-8963896	2.707570e-01	0.567
Signaling by ERBB2 KD Mutants	R-HSA-9664565	2.763844e-01	0.558
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	2.763844e-01	0.558
Regulation of CDH11 Expression and Function	R-HSA-9759475	2.763844e-01	0.558
Regulation of gene expression in beta cells	R-HSA-210745	2.763844e-01	0.558
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	2.850716e-01	0.545
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	2.859738e-01	0.544
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	2.875918e-01	0.541
Toll-like Receptor Cascades	R-HSA-168898	2.876455e-01	0.541
Downstream TCR signaling	R-HSA-202424	2.947923e-01	0.530
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	2.954884e-01	0.529
Interleukin-37 signaling	R-HSA-9008059	2.954884e-01	0.529
Erythropoietin activates RAS	R-HSA-9027284	2.977619e-01	0.526
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	2.977619e-01	0.526
G beta:gamma signalling through BTK	R-HSA-8964315	2.977619e-01	0.526
ERBB2 Regulates Cell Motility	R-HSA-6785631	2.977619e-01	0.526
Protein methylation	R-HSA-8876725	2.977619e-01	0.526
SLC-mediated transport of inorganic anions	R-HSA-9958790	2.991981e-01	0.524
Type I hemidesmosome assembly	R-HSA-446107	3.021590e-01	0.520
Signaling by MRAS-complex mutants	R-HSA-9660537	3.021590e-01	0.520
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	3.021590e-01	0.520
Axonal growth inhibition (RHOA activation)	R-HSA-193634	3.021590e-01	0.520
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	3.098441e-01	0.509
Interferon Signaling	R-HSA-913531	3.106836e-01	0.508
Signaling by ERBB4	R-HSA-1236394	3.112679e-01	0.507
Budding and maturation of HIV virion	R-HSA-162588	3.148021e-01	0.502
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	3.148021e-01	0.502
Evasion by RSV of host interferon responses	R-HSA-9833109	3.148021e-01	0.502
Ion homeostasis	R-HSA-5578775	3.152212e-01	0.501
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	3.163575e-01	0.500
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	3.163575e-01	0.500
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	3.164625e-01	0.500
Plasma lipoprotein clearance	R-HSA-8964043	3.164625e-01	0.500
Adaptive Immune System	R-HSA-1280218	3.225663e-01	0.491
Defective ALG9 causes CDG-1l	R-HSA-4720454	3.304955e-01	0.481
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	3.304955e-01	0.481
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.304955e-01	0.481
TWIK related potassium channel (TREK)	R-HSA-1299503	3.304955e-01	0.481
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	3.304955e-01	0.481
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	3.304955e-01	0.481
Interleukin-33 signaling	R-HSA-9014843	3.304955e-01	0.481
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	3.304955e-01	0.481
Intraflagellar transport	R-HSA-5620924	3.322264e-01	0.479
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	3.322514e-01	0.479
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	3.322514e-01	0.479
Syndecan interactions	R-HSA-3000170	3.322514e-01	0.479
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	3.338742e-01	0.476
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	3.338742e-01	0.476
Glycogen metabolism	R-HSA-8982491	3.338742e-01	0.476
DNA strand elongation	R-HSA-69190	3.342692e-01	0.476
Signaling by WNT in cancer	R-HSA-4791275	3.342692e-01	0.476
Signaling by TGFB family members	R-HSA-9006936	3.354498e-01	0.474
Lipophagy	R-HSA-9613354	3.386657e-01	0.470
AKT phosphorylates targets in the nucleus	R-HSA-198693	3.386657e-01	0.470
WNT mediated activation of DVL	R-HSA-201688	3.386657e-01	0.470
p75NTR regulates axonogenesis	R-HSA-193697	3.386657e-01	0.470
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	3.386657e-01	0.470
Unwinding of DNA	R-HSA-176974	3.386657e-01	0.470
Activation of the AP-1 family of transcription factors	R-HSA-450341	3.386657e-01	0.470
Regulation of CDH11 gene transcription	R-HSA-9762293	3.386657e-01	0.470
Respiratory syncytial virus genome replication	R-HSA-9834752	3.386657e-01	0.470
PI3K/AKT Signaling in Cancer	R-HSA-2219528	3.490982e-01	0.457
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	3.513937e-01	0.454
Resolution of Abasic Sites (AP sites)	R-HSA-73933	3.513937e-01	0.454
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	3.520421e-01	0.453
Acetylcholine regulates insulin secretion	R-HSA-399997	3.520421e-01	0.453
Disorders of Developmental Biology	R-HSA-9675151	3.520421e-01	0.453
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	3.538349e-01	0.451
FGFR1 mutant receptor activation	R-HSA-1839124	3.538349e-01	0.451
Regulation of necroptotic cell death	R-HSA-5675482	3.538349e-01	0.451
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	3.538349e-01	0.451
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	3.547316e-01	0.450
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	3.547316e-01	0.450
Transcription of the HIV genome	R-HSA-167172	3.547506e-01	0.450
Deadenylation-dependent mRNA decay	R-HSA-429914	3.594919e-01	0.444
Signaling by FGFR1 in disease	R-HSA-5655302	3.689827e-01	0.433
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	3.725033e-01	0.429
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	3.744069e-01	0.427
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	3.744069e-01	0.427
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	3.744069e-01	0.427
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	3.744069e-01	0.427
Signaling by NOTCH1 in Cancer	R-HSA-2644603	3.744069e-01	0.427
Sphingolipid de novo biosynthesis	R-HSA-1660661	3.744069e-01	0.427
Binding and entry of HIV virion	R-HSA-173107	3.745640e-01	0.426
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	3.745640e-01	0.426
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	3.745640e-01	0.426
EGFR Transactivation by Gastrin	R-HSA-2179392	3.745640e-01	0.426
DNA replication initiation	R-HSA-68952	3.745640e-01	0.426
Receptor Mediated Mitophagy	R-HSA-8934903	3.745640e-01	0.426
Signal attenuation	R-HSA-74749	3.745640e-01	0.426
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	3.745640e-01	0.426
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	3.745640e-01	0.426
Signaling by Leptin	R-HSA-2586552	3.745640e-01	0.426
Transport to the Golgi and subsequent modification	R-HSA-948021	3.754815e-01	0.425
VEGFR2 mediated cell proliferation	R-HSA-5218921	3.772070e-01	0.423
HDMs demethylate histones	R-HSA-3214842	3.772070e-01	0.423
PI3K events in ERBB2 signaling	R-HSA-1963642	3.790453e-01	0.421
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	3.790453e-01	0.421
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	3.790453e-01	0.421
Uptake and function of anthrax toxins	R-HSA-5210891	3.790453e-01	0.421
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	3.835837e-01	0.416
RNA Polymerase I Transcription Initiation	R-HSA-73762	3.866039e-01	0.413
Aquaporin-mediated transport	R-HSA-445717	3.893627e-01	0.410
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	3.930541e-01	0.406
Signaling by NOTCH2	R-HSA-1980145	3.930541e-01	0.406
Defective MMACHC causes MAHCC	R-HSA-3359474	3.944010e-01	0.404
Axonal growth stimulation	R-HSA-209563	3.944010e-01	0.404
MET activates PTPN11	R-HSA-8865999	3.944010e-01	0.404
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	3.944010e-01	0.404
CASP5-mediated substrate cleavage	R-HSA-9960525	3.944010e-01	0.404
CASP4-mediated substrate cleavage	R-HSA-9960519	3.944010e-01	0.404
MITF-M-regulated melanocyte development	R-HSA-9730414	3.944819e-01	0.404
Neurexins and neuroligins	R-HSA-6794361	3.965151e-01	0.402
Uptake and actions of bacterial toxins	R-HSA-5339562	3.965151e-01	0.402
Suppression of phagosomal maturation	R-HSA-9637687	3.996051e-01	0.398
TBC/RABGAPs	R-HSA-8854214	4.042210e-01	0.393
G beta:gamma signalling through PLC beta	R-HSA-418217	4.057986e-01	0.392
Mismatch Repair	R-HSA-5358508	4.057986e-01	0.392
Presynaptic function of Kainate receptors	R-HSA-500657	4.057986e-01	0.392
LGI-ADAM interactions	R-HSA-5682910	4.096378e-01	0.388
Formation of the posterior neural plate	R-HSA-9832991	4.096378e-01	0.388
Regulation of localization of FOXO transcription factors	R-HSA-9614399	4.096378e-01	0.388
Bicarbonate transporters	R-HSA-425381	4.096378e-01	0.388
Regulation of insulin secretion	R-HSA-422356	4.125657e-01	0.385
Transmission across Chemical Synapses	R-HSA-112315	4.144841e-01	0.382
MITF-M-dependent gene expression	R-HSA-9856651	4.213674e-01	0.375
Proteasome assembly	R-HSA-9907900	4.217997e-01	0.375
Netrin-1 signaling	R-HSA-373752	4.217997e-01	0.375
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	4.218587e-01	0.375
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	4.218587e-01	0.375
Cristae formation	R-HSA-8949613	4.218587e-01	0.375
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	4.218587e-01	0.375
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	4.218587e-01	0.375
ER Quality Control Compartment (ERQC)	R-HSA-901032	4.218587e-01	0.375
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	4.293088e-01	0.367
Triglyceride catabolism	R-HSA-163560	4.320673e-01	0.364
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.321995e-01	0.364
Signaling by FGFR2 IIIa TM	R-HSA-8851708	4.321995e-01	0.364
The NLRP3 inflammasome	R-HSA-844456	4.321995e-01	0.364
ABC-family proteins mediated transport	R-HSA-382556	4.365887e-01	0.360
Signaling by FGFR in disease	R-HSA-1226099	4.387579e-01	0.358
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	4.393067e-01	0.357
Somitogenesis	R-HSA-9824272	4.393067e-01	0.357
Mitochondrial biogenesis	R-HSA-1592230	4.422108e-01	0.354
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	4.437174e-01	0.353
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	4.437174e-01	0.353
Cytochrome c-mediated apoptotic response	R-HSA-111461	4.437174e-01	0.353
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	4.437174e-01	0.353
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	4.439057e-01	0.353
HIV elongation arrest and recovery	R-HSA-167287	4.439057e-01	0.353
Formation of the Early Elongation Complex	R-HSA-113418	4.439057e-01	0.353
Pausing and recovery of HIV elongation	R-HSA-167290	4.439057e-01	0.353
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	4.439057e-01	0.353
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	4.439057e-01	0.353
G alpha (z) signalling events	R-HSA-418597	4.447970e-01	0.352
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	4.522100e-01	0.345
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	4.522100e-01	0.345
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	4.522100e-01	0.345
GRB7 events in ERBB2 signaling	R-HSA-1306955	4.522100e-01	0.345
Signaling by MAP2K mutants	R-HSA-9652169	4.522100e-01	0.345
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	4.522100e-01	0.345
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	4.522100e-01	0.345
Transcriptional activation of p53 responsive genes	R-HSA-69560	4.522100e-01	0.345
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	4.522100e-01	0.345
AKT-mediated inactivation of FOXO1A	R-HSA-211163	4.522100e-01	0.345
NADE modulates death signalling	R-HSA-205025	4.522100e-01	0.345
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	4.522100e-01	0.345
FLT3 signaling through SRC family kinases	R-HSA-9706374	4.522100e-01	0.345
Dopamine receptors	R-HSA-390651	4.522100e-01	0.345
Protein-protein interactions at synapses	R-HSA-6794362	4.557350e-01	0.341
Signaling by TGFBR3	R-HSA-9839373	4.567106e-01	0.340
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	4.567106e-01	0.340
Regulation of pyruvate metabolism	R-HSA-9861718	4.567106e-01	0.340
Intrinsic Pathway for Apoptosis	R-HSA-109606	4.607637e-01	0.337
Signaling by Erythropoietin	R-HSA-9006335	4.656897e-01	0.332
mRNA Capping	R-HSA-72086	4.656897e-01	0.332
RIPK1-mediated regulated necrosis	R-HSA-5213460	4.705236e-01	0.327
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	4.766269e-01	0.322
Polymerase switching	R-HSA-69091	4.766732e-01	0.322
Leading Strand Synthesis	R-HSA-69109	4.766732e-01	0.322
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	4.766732e-01	0.322
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	R-HSA-3656253	4.766732e-01	0.322
Defective EXT2 causes exostoses 2	R-HSA-3656237	4.766732e-01	0.322
Scavenging by Class F Receptors	R-HSA-3000484	4.766732e-01	0.322
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	4.766732e-01	0.322
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	4.766732e-01	0.322
Translation of Structural Proteins	R-HSA-9694635	4.804945e-01	0.318
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	4.832613e-01	0.316
Lagging Strand Synthesis	R-HSA-69186	4.835969e-01	0.316
MyD88 deficiency (TLR2/4)	R-HSA-5602498	4.835969e-01	0.316
G-protein activation	R-HSA-202040	4.835969e-01	0.316
Zygotic genome activation (ZGA)	R-HSA-9819196	4.835969e-01	0.316
Basigin interactions	R-HSA-210991	4.835969e-01	0.316
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	4.835969e-01	0.316
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	4.871593e-01	0.312
Activation of BH3-only proteins	R-HSA-114452	4.871593e-01	0.312
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	4.894458e-01	0.310
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	4.910924e-01	0.309
Regulated Necrosis	R-HSA-5218859	4.933947e-01	0.307
Pyruvate metabolism	R-HSA-70268	4.949987e-01	0.305
Generic Transcription Pathway	R-HSA-212436	5.041768e-01	0.297
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	5.045039e-01	0.297
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	5.045039e-01	0.297
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	5.045039e-01	0.297
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	5.045039e-01	0.297
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	5.045039e-01	0.297
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	5.045039e-01	0.297
Muscarinic acetylcholine receptors	R-HSA-390648	5.045039e-01	0.297
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	5.045039e-01	0.297
Interleukin-36 pathway	R-HSA-9014826	5.045039e-01	0.297
NrCAM interactions	R-HSA-447038	5.045039e-01	0.297
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	5.045039e-01	0.297
SMAC (DIABLO) binds to IAPs	R-HSA-111463	5.045039e-01	0.297
Toxicity of botulinum toxin type C (botC)	R-HSA-5250971	5.045039e-01	0.297
Zinc efflux and compartmentalization by the SLC30 family	R-HSA-435368	5.045039e-01	0.297
Peroxisomal protein import	R-HSA-9033241	5.079555e-01	0.294
Triglyceride metabolism	R-HSA-8979227	5.079555e-01	0.294
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	5.081179e-01	0.294
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	5.081179e-01	0.294
HIV Transcription Elongation	R-HSA-167169	5.081179e-01	0.294
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	5.081179e-01	0.294
Nuclear signaling by ERBB4	R-HSA-1251985	5.081179e-01	0.294
Adipogenesis	R-HSA-9843745	5.081563e-01	0.294
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	5.084092e-01	0.294
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	5.084092e-01	0.294
Formation of axial mesoderm	R-HSA-9796292	5.084092e-01	0.294
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	5.084092e-01	0.294
Platelet Adhesion to exposed collagen	R-HSA-75892	5.084092e-01	0.294
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	5.084092e-01	0.294
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	5.084092e-01	0.294
Replication of the SARS-CoV-1 genome	R-HSA-9682706	5.084092e-01	0.294
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	5.084492e-01	0.294
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	5.084492e-01	0.294
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	5.084492e-01	0.294
Ribavirin ADME	R-HSA-9755088	5.084492e-01	0.294
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	5.183348e-01	0.285
PI3K Cascade	R-HSA-109704	5.247288e-01	0.280
Diseases of mitotic cell cycle	R-HSA-9675126	5.289772e-01	0.277
G0 and Early G1	R-HSA-1538133	5.289772e-01	0.277
Signaling by KIT in disease	R-HSA-9669938	5.326594e-01	0.274
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	5.326594e-01	0.274
Notch-HLH transcription pathway	R-HSA-350054	5.326594e-01	0.274
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	5.326594e-01	0.274
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	5.326594e-01	0.274
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	5.348959e-01	0.272
IRS-related events triggered by IGF1R	R-HSA-2428928	5.386206e-01	0.269
Formation of paraxial mesoderm	R-HSA-9793380	5.386206e-01	0.269
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	5.388581e-01	0.269
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	5.388581e-01	0.269
Zinc transporters	R-HSA-435354	5.388581e-01	0.269
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	5.388581e-01	0.269
Immune System	R-HSA-168256	5.394558e-01	0.268
The phototransduction cascade	R-HSA-2514856	5.412081e-01	0.267
Stimuli-sensing channels	R-HSA-2672351	5.428441e-01	0.265
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	5.445914e-01	0.264
HIV Transcription Initiation	R-HSA-167161	5.445914e-01	0.264
RNA Polymerase II Transcription Initiation	R-HSA-75953	5.445914e-01	0.264
Translation of Structural Proteins	R-HSA-9683701	5.445914e-01	0.264
Protein localization	R-HSA-9609507	5.472154e-01	0.262
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	5.492488e-01	0.260
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	5.492488e-01	0.260
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	5.492488e-01	0.260
Plus-strand DNA synthesis	R-HSA-164525	5.518083e-01	0.258
Nef Mediated CD8 Down-regulation	R-HSA-182218	5.518083e-01	0.258
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	5.518083e-01	0.258
PDE3B signalling	R-HSA-165160	5.518083e-01	0.258
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	5.518083e-01	0.258
PKB-mediated events	R-HSA-109703	5.518083e-01	0.258
PTK6 Regulates Cell Cycle	R-HSA-8849470	5.518083e-01	0.258
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	5.518083e-01	0.258
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	5.518083e-01	0.258
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	5.518083e-01	0.258
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	5.518083e-01	0.258
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	5.518083e-01	0.258
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	5.518083e-01	0.258
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	5.561816e-01	0.255
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	5.561816e-01	0.255
Growth hormone receptor signaling	R-HSA-982772	5.561816e-01	0.255
Transcriptional Regulation by NPAS4	R-HSA-9634815	5.574333e-01	0.254
Processive synthesis on the lagging strand	R-HSA-69183	5.679764e-01	0.246
p38MAPK events	R-HSA-171007	5.679764e-01	0.246
Other semaphorin interactions	R-HSA-416700	5.679764e-01	0.246
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	5.679764e-01	0.246
Formation of the anterior neural plate	R-HSA-9823739	5.679764e-01	0.246
Extra-nuclear estrogen signaling	R-HSA-9009391	5.680794e-01	0.246
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	5.684800e-01	0.245
Resolution of D-Loop Structures	R-HSA-5693537	5.690525e-01	0.245
Effects of PIP2 hydrolysis	R-HSA-114508	5.690525e-01	0.245
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	5.690525e-01	0.245
Miscellaneous transport and binding events	R-HSA-5223345	5.690525e-01	0.245
Plasma lipoprotein assembly	R-HSA-8963898	5.789789e-01	0.237
RNA Polymerase II Promoter Escape	R-HSA-73776	5.797316e-01	0.237
Response of Mtb to phagocytosis	R-HSA-9637690	5.797316e-01	0.237
Neuronal System	R-HSA-112316	5.800337e-01	0.237
IGF1R signaling cascade	R-HSA-2428924	5.830687e-01	0.234
Ion transport by P-type ATPases	R-HSA-936837	5.830687e-01	0.234
Inositol phosphate metabolism	R-HSA-1483249	5.878863e-01	0.231
Signal amplification	R-HSA-392518	5.883619e-01	0.230
Calnexin/calreticulin cycle	R-HSA-901042	5.883619e-01	0.230
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	5.945992e-01	0.226
STAT5 Activation	R-HSA-9645135	5.945992e-01	0.226
Uncoating of the HIV Virion	R-HSA-162585	5.945992e-01	0.226
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	5.945992e-01	0.226
Neurofascin interactions	R-HSA-447043	5.945992e-01	0.226
Abacavir transmembrane transport	R-HSA-2161517	5.945992e-01	0.226
Regulation of NFE2L2 gene expression	R-HSA-9818749	5.945992e-01	0.226
CREB phosphorylation	R-HSA-199920	5.945992e-01	0.226
HDL clearance	R-HSA-8964011	5.945992e-01	0.226
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	5.945992e-01	0.226
WNT5A-dependent internalization of FZD4	R-HSA-5099900	5.957405e-01	0.225
Phase 4 - resting membrane potential	R-HSA-5576886	5.957405e-01	0.225
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	5.957405e-01	0.225
Amine ligand-binding receptors	R-HSA-375280	5.967474e-01	0.224
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	5.974120e-01	0.224
TGFBR3 expression	R-HSA-9839394	6.010228e-01	0.221
Interleukin-7 signaling	R-HSA-1266695	6.010228e-01	0.221
PERK regulates gene expression	R-HSA-381042	6.071546e-01	0.217
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	6.133701e-01	0.212
tRNA processing	R-HSA-72306	6.187616e-01	0.208
GRB2 events in ERBB2 signaling	R-HSA-1963640	6.221437e-01	0.206
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	6.221437e-01	0.206
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	6.221437e-01	0.206
Defective B4GALT7 causes EDS, progeroid type	R-HSA-3560783	6.221437e-01	0.206
Defective B3GALT6 causes EDSP2 and SEMDJL1	R-HSA-4420332	6.221437e-01	0.206
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	6.221437e-01	0.206
TRAF3-dependent IRF activation pathway	R-HSA-918233	6.221437e-01	0.206
MET activates PTK2 signaling	R-HSA-8874081	6.222923e-01	0.206
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	6.222923e-01	0.206
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	6.222923e-01	0.206
RUNX2 regulates bone development	R-HSA-8941326	6.254127e-01	0.204
MET activates PI3K/AKT signaling	R-HSA-8851907	6.333070e-01	0.198
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	6.333070e-01	0.198
TRIF-mediated programmed cell death	R-HSA-2562578	6.333070e-01	0.198
IFNG signaling activates MAPKs	R-HSA-9732724	6.333070e-01	0.198
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	6.333070e-01	0.198
Disinhibition of SNARE formation	R-HSA-114516	6.333070e-01	0.198
PTK6 Expression	R-HSA-8849473	6.333070e-01	0.198
Nef Mediated CD4 Down-regulation	R-HSA-167590	6.333070e-01	0.198
Activated NTRK2 signals through CDK5	R-HSA-9032845	6.333070e-01	0.198
NOSTRIN mediated eNOS trafficking	R-HSA-203641	6.333070e-01	0.198
Activation of PUMA and translocation to mitochondria	R-HSA-139915	6.333070e-01	0.198
Cation-coupled Chloride cotransporters	R-HSA-426117	6.333070e-01	0.198
Netrin mediated repulsion signals	R-HSA-418886	6.333070e-01	0.198
IRS-mediated signalling	R-HSA-112399	6.341559e-01	0.198
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	6.354840e-01	0.197
Processive synthesis on the C-strand of the telomere	R-HSA-174414	6.427729e-01	0.192
Signaling by NTRK2 (TRKB)	R-HSA-9006115	6.427729e-01	0.192
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	6.435577e-01	0.191
Defective B3GAT3 causes JDSSDHD	R-HSA-3560801	6.471927e-01	0.189
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	6.471927e-01	0.189
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	6.471927e-01	0.189
Specification of primordial germ cells	R-HSA-9827857	6.471927e-01	0.189
Replication of the SARS-CoV-2 genome	R-HSA-9694686	6.471927e-01	0.189
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	6.602708e-01	0.180
Gluconeogenesis	R-HSA-70263	6.607456e-01	0.180
Disorders of transmembrane transporters	R-HSA-5619115	6.621286e-01	0.179
Pyroptosis	R-HSA-5620971	6.624567e-01	0.179
Inflammasomes	R-HSA-622312	6.624567e-01	0.179
Activation of kainate receptors upon glutamate binding	R-HSA-451326	6.624567e-01	0.179
Regulation of beta-cell development	R-HSA-186712	6.625461e-01	0.179
FOXO-mediated transcription	R-HSA-9614085	6.637152e-01	0.178
Reverse Transcription of HIV RNA	R-HSA-162589	6.683210e-01	0.175
Minus-strand DNA synthesis	R-HSA-164516	6.683210e-01	0.175
RSK activation	R-HSA-444257	6.683210e-01	0.175
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	6.683210e-01	0.175
phospho-PLA2 pathway	R-HSA-111995	6.683210e-01	0.175
EGFR interacts with phospholipase C-gamma	R-HSA-212718	6.683210e-01	0.175
Activated NTRK2 signals through PI3K	R-HSA-9028335	6.683210e-01	0.175
MET receptor recycling	R-HSA-8875656	6.683210e-01	0.175
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	6.683210e-01	0.175
FGFR1b ligand binding and activation	R-HSA-190370	6.683210e-01	0.175
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	6.683210e-01	0.175
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	6.683210e-01	0.175
TGFBR3 PTM regulation	R-HSA-9839383	6.683210e-01	0.175
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	6.683210e-01	0.175
Activated NTRK2 signals through FYN	R-HSA-9032500	6.683210e-01	0.175
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	6.709054e-01	0.173
Synaptic adhesion-like molecules	R-HSA-8849932	6.709054e-01	0.173
Apoptotic factor-mediated response	R-HSA-111471	6.709054e-01	0.173
Nephron development	R-HSA-9831926	6.709054e-01	0.173
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	6.756732e-01	0.170
Metabolism of polyamines	R-HSA-351202	6.762111e-01	0.170
Pentose phosphate pathway	R-HSA-71336	6.768525e-01	0.170
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	6.768525e-01	0.170
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	6.777268e-01	0.169
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	6.790620e-01	0.168
Impaired BRCA2 binding to RAD51	R-HSA-9709570	6.813407e-01	0.167
Glucagon-type ligand receptors	R-HSA-420092	6.813407e-01	0.167
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	6.863798e-01	0.163
Ion channel transport	R-HSA-983712	6.892279e-01	0.162
Cytoprotection by HMOX1	R-HSA-9707564	6.914013e-01	0.160
Diseases of Immune System	R-HSA-5260271	6.928623e-01	0.159
Diseases associated with the TLR signaling cascade	R-HSA-5602358	6.928623e-01	0.159
Generation of second messenger molecules	R-HSA-202433	6.928623e-01	0.159
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	6.932100e-01	0.159
Late SARS-CoV-2 Infection Events	R-HSA-9772573	6.932100e-01	0.159
Impaired BRCA2 binding to PALB2	R-HSA-9709603	6.933085e-01	0.159
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	6.933085e-01	0.159
Other interleukin signaling	R-HSA-449836	6.933085e-01	0.159
Maturation of nucleoprotein	R-HSA-9694631	6.933085e-01	0.159
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	6.933085e-01	0.159
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	6.994268e-01	0.155
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	6.994268e-01	0.155
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	6.999935e-01	0.155
Inactivation of CDC42 and RAC1	R-HSA-428543	6.999935e-01	0.155
Calcineurin activates NFAT	R-HSA-2025928	6.999935e-01	0.155
Regulation of signaling by NODAL	R-HSA-1433617	6.999935e-01	0.155
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	6.999935e-01	0.155
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	6.999935e-01	0.155
Regulated proteolysis of p75NTR	R-HSA-193692	6.999935e-01	0.155
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	6.999935e-01	0.155
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	6.999935e-01	0.155
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	6.999935e-01	0.155
Butyrophilin (BTN) family interactions	R-HSA-8851680	6.999935e-01	0.155
Potential therapeutics for SARS	R-HSA-9679191	7.081631e-01	0.150
Transcriptional Regulation by VENTX	R-HSA-8853884	7.082982e-01	0.150
Disease	R-HSA-1643685	7.137251e-01	0.146
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	7.143092e-01	0.146
Regulation of PD-L1(CD274) translation	R-HSA-9909620	7.144358e-01	0.146
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	7.144358e-01	0.146
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	7.144358e-01	0.146
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	7.144358e-01	0.146
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	7.144358e-01	0.146
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	7.144358e-01	0.146
Signaling by NODAL	R-HSA-1181150	7.144358e-01	0.146
Formation of definitive endoderm	R-HSA-9823730	7.144358e-01	0.146
Downstream signal transduction	R-HSA-186763	7.167213e-01	0.145
Trafficking of AMPA receptors	R-HSA-399719	7.167213e-01	0.145
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	7.167213e-01	0.145
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	7.231611e-01	0.141
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	7.231611e-01	0.141
SLC-mediated transport of neurotransmitters	R-HSA-442660	7.231611e-01	0.141
Insulin receptor signalling cascade	R-HSA-74751	7.272194e-01	0.138
MAPK3 (ERK1) activation	R-HSA-110056	7.286432e-01	0.137
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	7.286432e-01	0.137
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	7.286432e-01	0.137
Formation of apoptosome	R-HSA-111458	7.286432e-01	0.137
Peptide hormone biosynthesis	R-HSA-209952	7.286432e-01	0.137
Regulation of the apoptosome activity	R-HSA-9627069	7.286432e-01	0.137
Tandem pore domain potassium channels	R-HSA-1296346	7.286432e-01	0.137
Golgi Associated Vesicle Biogenesis	R-HSA-432722	7.309192e-01	0.136
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	7.332337e-01	0.135
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	7.343268e-01	0.134
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	7.343268e-01	0.134
Signalling to RAS	R-HSA-167044	7.343268e-01	0.134
Cytosolic tRNA aminoacylation	R-HSA-379716	7.374538e-01	0.132
Platelet homeostasis	R-HSA-418346	7.437930e-01	0.129
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	7.441415e-01	0.128
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	7.489770e-01	0.126
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	7.489770e-01	0.126
Attachment and Entry	R-HSA-9694614	7.530247e-01	0.123
Mitochondrial calcium ion transport	R-HSA-8949215	7.530247e-01	0.123
Signaling by NTRK3 (TRKC)	R-HSA-9034015	7.530247e-01	0.123
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	7.530247e-01	0.123
vRNP Assembly	R-HSA-192905	7.545586e-01	0.122
Synthesis of PI	R-HSA-1483226	7.545586e-01	0.122
RHOBTB3 ATPase cycle	R-HSA-9706019	7.545586e-01	0.122
CD163 mediating an anti-inflammatory response	R-HSA-9662834	7.545586e-01	0.122
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	7.545586e-01	0.122
Vitamin B1 (thiamin) metabolism	R-HSA-196819	7.545586e-01	0.122
Suppression of apoptosis	R-HSA-9635465	7.545586e-01	0.122
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	7.545586e-01	0.122
Interleukin-2 signaling	R-HSA-9020558	7.545586e-01	0.122
Dissolution of Fibrin Clot	R-HSA-75205	7.545586e-01	0.122
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	7.639667e-01	0.117
Neddylation	R-HSA-8951664	7.697418e-01	0.114
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	7.705760e-01	0.113
Condensation of Prometaphase Chromosomes	R-HSA-2514853	7.780003e-01	0.109
Synthesis of diphthamide-EEF2	R-HSA-5358493	7.780003e-01	0.109
ERKs are inactivated	R-HSA-202670	7.780003e-01	0.109
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	7.780003e-01	0.109
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	7.780003e-01	0.109
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	7.780003e-01	0.109
Proton-coupled monocarboxylate transport	R-HSA-433692	7.780003e-01	0.109
Sensing of DNA Double Strand Breaks	R-HSA-5693548	7.780003e-01	0.109
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	7.782204e-01	0.109
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	7.782204e-01	0.109
eNOS activation	R-HSA-203615	7.782204e-01	0.109
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	7.782204e-01	0.109
Gastrulation	R-HSA-9758941	7.834540e-01	0.106
Interleukin receptor SHC signaling	R-HSA-912526	7.870292e-01	0.104
Formation of the ureteric bud	R-HSA-9830674	7.870292e-01	0.104
Diseases of DNA repair	R-HSA-9675135	7.890481e-01	0.103
Early SARS-CoV-2 Infection Events	R-HSA-9772572	7.899343e-01	0.102
G alpha (s) signalling events	R-HSA-418555	7.903391e-01	0.102
FCGR3A-mediated phagocytosis	R-HSA-9664422	7.908243e-01	0.102
Leishmania phagocytosis	R-HSA-9664417	7.908243e-01	0.102
Parasite infection	R-HSA-9664407	7.908243e-01	0.102
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	7.917577e-01	0.101
Cardiac conduction	R-HSA-5576891	7.988339e-01	0.098
RUNX3 regulates p14-ARF	R-HSA-8951936	7.992044e-01	0.097
Repression of WNT target genes	R-HSA-4641265	7.992044e-01	0.097
RUNX3 regulates NOTCH signaling	R-HSA-8941856	7.992044e-01	0.097
GRB2 events in EGFR signaling	R-HSA-179812	7.992044e-01	0.097
Serotonin clearance from the synaptic cleft	R-HSA-380615	7.992044e-01	0.097
Signaling by LTK	R-HSA-9842663	7.992044e-01	0.097
Trafficking and processing of endosomal TLR	R-HSA-1679131	7.992044e-01	0.097
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	7.992044e-01	0.097
Interleukin-15 signaling	R-HSA-8983432	7.992044e-01	0.097
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	7.992044e-01	0.097
OAS antiviral response	R-HSA-8983711	7.992044e-01	0.097
Extension of Telomeres	R-HSA-180786	8.004352e-01	0.097
Thromboxane signalling through TP receptor	R-HSA-428930	8.024338e-01	0.096
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	8.024338e-01	0.096
TRAF6 mediated NF-kB activation	R-HSA-933542	8.024338e-01	0.096
Leishmania infection	R-HSA-9658195	8.035174e-01	0.095
Parasitic Infection Pathways	R-HSA-9824443	8.035174e-01	0.095
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	8.037729e-01	0.095
GPVI-mediated activation cascade	R-HSA-114604	8.045995e-01	0.094
Glycosphingolipid transport	R-HSA-9845576	8.045995e-01	0.094
G1/S-Specific Transcription	R-HSA-69205	8.045995e-01	0.094
FGFR2 mutant receptor activation	R-HSA-1839126	8.045995e-01	0.094
trans-Golgi Network Vesicle Budding	R-HSA-199992	8.115768e-01	0.091
Voltage gated Potassium channels	R-HSA-1296072	8.167680e-01	0.088
G protein gated Potassium channels	R-HSA-1296059	8.168399e-01	0.088
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	8.168399e-01	0.088
Activation of G protein gated Potassium channels	R-HSA-1296041	8.168399e-01	0.088
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	8.168399e-01	0.088
Polymerase switching on the C-strand of the telomere	R-HSA-174411	8.168399e-01	0.088
Glycogen breakdown (glycogenolysis)	R-HSA-70221	8.168399e-01	0.088
Laminin interactions	R-HSA-3000157	8.168399e-01	0.088
MicroRNA (miRNA) biogenesis	R-HSA-203927	8.168399e-01	0.088
Acyl chain remodelling of PS	R-HSA-1482801	8.168399e-01	0.088
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	8.168399e-01	0.088
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	8.168399e-01	0.088
Formation of the nephric duct	R-HSA-9830364	8.168399e-01	0.088
Adenylate cyclase activating pathway	R-HSA-170660	8.183843e-01	0.087
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	8.183843e-01	0.087
Processing of SMDT1	R-HSA-8949664	8.183843e-01	0.087
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	8.183843e-01	0.087
FGFR1c ligand binding and activation	R-HSA-190373	8.183843e-01	0.087
PI5P Regulates TP53 Acetylation	R-HSA-6811555	8.183843e-01	0.087
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	8.183843e-01	0.087
Maturation of nucleoprotein	R-HSA-9683610	8.183843e-01	0.087
Interleukin-6 signaling	R-HSA-1059683	8.183843e-01	0.087
RSV-host interactions	R-HSA-9833110	8.204571e-01	0.086
Ca2+ pathway	R-HSA-4086398	8.205172e-01	0.086
Diseases of carbohydrate metabolism	R-HSA-5663084	8.205172e-01	0.086
FCERI mediated NF-kB activation	R-HSA-2871837	8.240603e-01	0.084
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	8.282863e-01	0.082
Mitochondrial protein import	R-HSA-1268020	8.294587e-01	0.081
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	8.294587e-01	0.081
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	8.302978e-01	0.081
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	8.302978e-01	0.081
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	8.302978e-01	0.081
Abacavir ADME	R-HSA-2161522	8.302978e-01	0.081
Signaling by FGFR2 in disease	R-HSA-5655253	8.321929e-01	0.080
Removal of the Flap Intermediate	R-HSA-69166	8.357332e-01	0.078
Retrograde neurotrophin signalling	R-HSA-177504	8.357332e-01	0.078
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	8.357332e-01	0.078
cGMP effects	R-HSA-418457	8.357332e-01	0.078
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	8.357332e-01	0.078
Hydrolysis of LPC	R-HSA-1483115	8.357332e-01	0.078
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	8.357332e-01	0.078
Signaling by FGFR4 in disease	R-HSA-5655291	8.357332e-01	0.078
Physiological factors	R-HSA-5578768	8.357332e-01	0.078
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.357332e-01	0.078
Non-canonical inflammasome activation	R-HSA-9686114	8.357332e-01	0.078
Ciprofloxacin ADME	R-HSA-9793528	8.357332e-01	0.078
Acyl chain remodeling of CL	R-HSA-1482798	8.357332e-01	0.078
P2Y receptors	R-HSA-417957	8.357332e-01	0.078
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	8.373867e-01	0.077
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	8.379477e-01	0.077
CD28 dependent PI3K/Akt signaling	R-HSA-389357	8.428570e-01	0.074
Triglyceride biosynthesis	R-HSA-75109	8.428570e-01	0.074
Interleukin-2 family signaling	R-HSA-451927	8.494673e-01	0.071
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	8.514258e-01	0.070
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	8.514258e-01	0.070
Adenylate cyclase inhibitory pathway	R-HSA-170670	8.514258e-01	0.070
SHC1 events in EGFR signaling	R-HSA-180336	8.514258e-01	0.070
Protein lipoylation	R-HSA-9857492	8.514258e-01	0.070
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	8.514258e-01	0.070
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	8.514258e-01	0.070
Dopamine clearance from the synaptic cleft	R-HSA-379401	8.514258e-01	0.070
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	8.514258e-01	0.070
Transport and metabolism of PAPS	R-HSA-174362	8.514258e-01	0.070
Activation of BAD and translocation to mitochondria	R-HSA-111447	8.514258e-01	0.070
IRF3-mediated induction of type I IFN	R-HSA-3270619	8.514258e-01	0.070
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	8.514258e-01	0.070
DNA Damage Reversal	R-HSA-73942	8.514258e-01	0.070
Phase 0 - rapid depolarisation	R-HSA-5576892	8.545665e-01	0.068
Metabolism of proteins	R-HSA-392499	8.550572e-01	0.068
Maturation of spike protein	R-HSA-9694548	8.591783e-01	0.066
Integrin cell surface interactions	R-HSA-216083	8.602670e-01	0.065
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	8.656201e-01	0.063
Phosphorylation of the APC/C	R-HSA-176412	8.656201e-01	0.063
Defective GALNT12 causes CRCS1	R-HSA-5083636	8.656201e-01	0.063
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	8.656201e-01	0.063
Defective GALNT3 causes HFTC	R-HSA-5083625	8.656201e-01	0.063
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	8.656201e-01	0.063
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	8.656201e-01	0.063
Killing mechanisms	R-HSA-9664420	8.656201e-01	0.063
Class I peroxisomal membrane protein import	R-HSA-9603798	8.656201e-01	0.063
Activation of SMO	R-HSA-5635838	8.656201e-01	0.063
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	8.656201e-01	0.063
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	8.656201e-01	0.063
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	8.656201e-01	0.063
Kidney development	R-HSA-9830369	8.701189e-01	0.060
DAP12 signaling	R-HSA-2424491	8.756255e-01	0.058
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	8.756255e-01	0.058
Neurotransmitter clearance	R-HSA-112311	8.756255e-01	0.058
GABA synthesis, release, reuptake and degradation	R-HSA-888590	8.756255e-01	0.058
Activation of GABAB receptors	R-HSA-991365	8.769628e-01	0.057
GABA B receptor activation	R-HSA-977444	8.769628e-01	0.057
PI Metabolism	R-HSA-1483255	8.779087e-01	0.057
Glycine degradation	R-HSA-6783984	8.784590e-01	0.056
Fibronectin matrix formation	R-HSA-1566977	8.784590e-01	0.056
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	8.784590e-01	0.056
Heme assimilation	R-HSA-9927020	8.784590e-01	0.056
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	8.784590e-01	0.056
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	8.784590e-01	0.056
Passive transport by Aquaporins	R-HSA-432047	8.784590e-01	0.056
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	8.784590e-01	0.056
tRNA modification in the mitochondrion	R-HSA-6787450	8.784590e-01	0.056
Detoxification of Reactive Oxygen Species	R-HSA-3299685	8.829193e-01	0.054
Signaling by Insulin receptor	R-HSA-74752	8.844645e-01	0.053
SLC transporter disorders	R-HSA-5619102	8.848913e-01	0.053
Molecules associated with elastic fibres	R-HSA-2129379	8.850662e-01	0.053
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	8.900720e-01	0.051
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	8.900720e-01	0.051
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	8.900720e-01	0.051
Elevation of cytosolic Ca2+ levels	R-HSA-139853	8.900720e-01	0.051
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	8.900720e-01	0.051
Inwardly rectifying K+ channels	R-HSA-1296065	8.938391e-01	0.049
HS-GAG degradation	R-HSA-2024096	8.938391e-01	0.049
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	8.999044e-01	0.046
RNA Polymerase III Transcription Termination	R-HSA-73980	9.005760e-01	0.045
FGFR1 ligand binding and activation	R-HSA-190242	9.005760e-01	0.045
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	9.005760e-01	0.045
Nucleotide-like (purinergic) receptors	R-HSA-418038	9.005760e-01	0.045
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	9.005760e-01	0.045
Cardiogenesis	R-HSA-9733709	9.019855e-01	0.045
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.066485e-01	0.043
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.066485e-01	0.043
Peptide hormone metabolism	R-HSA-2980736	9.073048e-01	0.042
tRNA Aminoacylation	R-HSA-379724	9.088122e-01	0.042
Heme degradation	R-HSA-189483	9.095451e-01	0.041
PI-3K cascade:FGFR3	R-HSA-5654710	9.100769e-01	0.041
Germ layer formation at gastrulation	R-HSA-9754189	9.100769e-01	0.041
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	9.100769e-01	0.041
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	9.100769e-01	0.041
O2/CO2 exchange in erythrocytes	R-HSA-1480926	9.100769e-01	0.041
Methionine salvage pathway	R-HSA-1237112	9.100769e-01	0.041
Pre-NOTCH Processing in Golgi	R-HSA-1912420	9.100769e-01	0.041
STING mediated induction of host immune responses	R-HSA-1834941	9.100769e-01	0.041
Innate Immune System	R-HSA-168249	9.111588e-01	0.040
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.165556e-01	0.038
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.165556e-01	0.038
Iron uptake and transport	R-HSA-917937	9.180273e-01	0.037
PI-3K cascade:FGFR4	R-HSA-5654720	9.186704e-01	0.037
Formation of ATP by chemiosmotic coupling	R-HSA-163210	9.186704e-01	0.037
Acyl chain remodelling of PI	R-HSA-1482922	9.186704e-01	0.037
Common Pathway of Fibrin Clot Formation	R-HSA-140875	9.186704e-01	0.037
Pregnenolone biosynthesis	R-HSA-196108	9.186704e-01	0.037
Signaling by PDGF	R-HSA-186797	9.197439e-01	0.036
NCAM signaling for neurite out-growth	R-HSA-375165	9.197439e-01	0.036
TNFR1-induced proapoptotic signaling	R-HSA-5357786	9.264431e-01	0.033
Abacavir metabolism	R-HSA-2161541	9.264431e-01	0.033
Acyl chain remodelling of PG	R-HSA-1482925	9.264431e-01	0.033
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.272486e-01	0.033
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	9.285581e-01	0.032
HS-GAG biosynthesis	R-HSA-2022928	9.290710e-01	0.032
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	9.290710e-01	0.032
RNA Polymerase III Transcription	R-HSA-74158	9.290710e-01	0.032
Lysosome Vesicle Biogenesis	R-HSA-432720	9.290710e-01	0.032
Azathioprine ADME	R-HSA-9748787	9.296927e-01	0.032
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	9.334734e-01	0.030
Androgen biosynthesis	R-HSA-193048	9.334734e-01	0.030
Molybdenum cofactor biosynthesis	R-HSA-947581	9.334734e-01	0.030
Glucocorticoid biosynthesis	R-HSA-194002	9.334734e-01	0.030
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	9.334734e-01	0.030
TRAF6 mediated IRF7 activation	R-HSA-933541	9.346421e-01	0.029
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.397966e-01	0.027
Elastic fibre formation	R-HSA-1566948	9.397966e-01	0.027
PI-3K cascade:FGFR1	R-HSA-5654689	9.398321e-01	0.027
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	9.398321e-01	0.027
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	9.398321e-01	0.027
RAF-independent MAPK1/3 activation	R-HSA-112409	9.398321e-01	0.027
LDL clearance	R-HSA-8964038	9.398321e-01	0.027
Ethanol oxidation	R-HSA-71384	9.398321e-01	0.027
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	9.398321e-01	0.027
Neurotoxicity of clostridium toxins	R-HSA-168799	9.398321e-01	0.027
Post-translational protein modification	R-HSA-597592	9.408374e-01	0.026
TP53 Regulates Metabolic Genes	R-HSA-5628897	9.419231e-01	0.026
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.428831e-01	0.026
Interferon alpha/beta signaling	R-HSA-909733	9.448806e-01	0.025
Termination of O-glycan biosynthesis	R-HSA-977068	9.455834e-01	0.024
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	9.455834e-01	0.024
Regulation of PTEN mRNA translation	R-HSA-8943723	9.455834e-01	0.024
Free fatty acids regulate insulin secretion	R-HSA-400451	9.455834e-01	0.024
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	9.455834e-01	0.024
Mitochondrial protein degradation	R-HSA-9837999	9.480748e-01	0.023
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	9.507853e-01	0.022
Complex III assembly	R-HSA-9865881	9.507853e-01	0.022
Interleukin-6 family signaling	R-HSA-6783589	9.507853e-01	0.022
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.530399e-01	0.021
PI-3K cascade:FGFR2	R-HSA-5654695	9.554901e-01	0.020
Tight junction interactions	R-HSA-420029	9.554901e-01	0.020
Defects in cobalamin (B12) metabolism	R-HSA-3296469	9.554901e-01	0.020
Hyaluronan degradation	R-HSA-2160916	9.554901e-01	0.020
Beta-oxidation of pristanoyl-CoA	R-HSA-389887	9.554901e-01	0.020
ECM proteoglycans	R-HSA-3000178	9.557261e-01	0.020
Potassium Channels	R-HSA-1296071	9.564883e-01	0.019
Intra-Golgi traffic	R-HSA-6811438	9.567988e-01	0.019
Heme biosynthesis	R-HSA-189451	9.567988e-01	0.019
Dectin-2 family	R-HSA-5621480	9.578484e-01	0.019
Linoleic acid (LA) metabolism	R-HSA-2046105	9.597455e-01	0.018
TRP channels	R-HSA-3295583	9.597455e-01	0.018
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	9.597455e-01	0.018
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.608434e-01	0.017
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.608759e-01	0.017
Cobalamin (Cbl) metabolism	R-HSA-9759218	9.635942e-01	0.016
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.635942e-01	0.016
Signaling by FGFR3 in disease	R-HSA-5655332	9.635942e-01	0.016
Synthesis of PE	R-HSA-1483213	9.635942e-01	0.016
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.635942e-01	0.016
Maturation of hRSV A proteins	R-HSA-9828806	9.635942e-01	0.016
GABA receptor activation	R-HSA-977443	9.663278e-01	0.015
DAP12 interactions	R-HSA-2172127	9.664228e-01	0.015
Surfactant metabolism	R-HSA-5683826	9.664228e-01	0.015
Telomere Extension By Telomerase	R-HSA-171319	9.670752e-01	0.015
Insulin receptor recycling	R-HSA-77387	9.670752e-01	0.015
Neurotransmitter release cycle	R-HSA-112310	9.697325e-01	0.013
Leishmania parasite growth and survival	R-HSA-9664433	9.700150e-01	0.013
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.700150e-01	0.013
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.702235e-01	0.013
Downstream signaling of activated FGFR3	R-HSA-5654708	9.702235e-01	0.013
Platelet calcium homeostasis	R-HSA-418360	9.702235e-01	0.013
Cholesterol biosynthesis	R-HSA-191273	9.726814e-01	0.012
RNA Polymerase III Transcription Initiation	R-HSA-76046	9.730709e-01	0.012
Downstream signaling of activated FGFR4	R-HSA-5654716	9.730709e-01	0.012
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.730709e-01	0.012
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.739654e-01	0.011
Cargo concentration in the ER	R-HSA-5694530	9.756462e-01	0.011
Metal ion SLC transporters	R-HSA-425410	9.760942e-01	0.011
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.767207e-01	0.010
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.767710e-01	0.010
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.786929e-01	0.009
PPARA activates gene expression	R-HSA-1989781	9.787561e-01	0.009
Recycling of bile acids and salts	R-HSA-159418	9.800819e-01	0.009
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.809141e-01	0.008
Complex IV assembly	R-HSA-9864848	9.815175e-01	0.008
Acyl chain remodelling of PC	R-HSA-1482788	9.819871e-01	0.008
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.819871e-01	0.008
Hyaluronan metabolism	R-HSA-2142845	9.837101e-01	0.007
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.837101e-01	0.007
COPII-mediated vesicle transport	R-HSA-204005	9.843840e-01	0.007
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.843840e-01	0.007
Nucleotide biosynthesis	R-HSA-8956320	9.844479e-01	0.007
FCERI mediated MAPK activation	R-HSA-2871796	9.848417e-01	0.007
Downstream signaling of activated FGFR2	R-HSA-5654696	9.852684e-01	0.006
Downstream signaling of activated FGFR1	R-HSA-5654687	9.852684e-01	0.006
Acyl chain remodelling of PE	R-HSA-1482839	9.852684e-01	0.006
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.852684e-01	0.006
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.854995e-01	0.006
Metabolism of porphyrins	R-HSA-189445	9.855607e-01	0.006
G alpha (q) signalling events	R-HSA-416476	9.861466e-01	0.006
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.866777e-01	0.006
Asparagine N-linked glycosylation	R-HSA-446203	9.867336e-01	0.006
Metabolism of folate and pterines	R-HSA-196757	9.879523e-01	0.005
Synthesis of PA	R-HSA-1483166	9.890150e-01	0.005
Diseases associated with N-glycosylation of proteins	R-HSA-3781860	9.901475e-01	0.004
G alpha (i) signalling events	R-HSA-418594	9.905656e-01	0.004
Heparan sulfate/heparin (HS-GAG) metabolism	R-HSA-1638091	9.907782e-01	0.004
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.907782e-01	0.004
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.910903e-01	0.004
Endogenous sterols	R-HSA-211976	9.922638e-01	0.003
Scavenging by Class A Receptors	R-HSA-3000480	9.927140e-01	0.003
Visual phototransduction	R-HSA-2187338	9.930370e-01	0.003
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.934113e-01	0.003
Extracellular matrix organization	R-HSA-1474244	9.935172e-01	0.003
Formation of the cornified envelope	R-HSA-6809371	9.939966e-01	0.003
Synthesis of very long-chain fatty acyl-CoAs	R-HSA-75876	9.940419e-01	0.003
CD22 mediated BCR regulation	R-HSA-5690714	9.940631e-01	0.003
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.946122e-01	0.002
Post-translational protein phosphorylation	R-HSA-8957275	9.949291e-01	0.002
Metabolism of steroid hormones	R-HSA-196071	9.954503e-01	0.002
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.954503e-01	0.002
Synthesis of PC	R-HSA-1483191	9.960161e-01	0.002
GPCR downstream signalling	R-HSA-388396	9.961342e-01	0.002
Interferon gamma signaling	R-HSA-877300	9.967364e-01	0.001
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.967424e-01	0.001
Chemokine receptors bind chemokines	R-HSA-380108	9.967424e-01	0.001
Retinoid metabolism and transport	R-HSA-975634	9.968158e-01	0.001
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.970544e-01	0.001
Class B/2 (Secretin family receptors)	R-HSA-373080	9.971228e-01	0.001
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.975426e-01	0.001
Amino acids regulate mTORC1	R-HSA-9639288	9.978222e-01	0.001
FCGR activation	R-HSA-2029481	9.979350e-01	0.001
Metabolism of nucleotides	R-HSA-15869	9.979674e-01	0.001
Paracetamol ADME	R-HSA-9753281	9.982194e-01	0.001
Nuclear Receptor transcription pathway	R-HSA-383280	9.983033e-01	0.001
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.985217e-01	0.001
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.987067e-01	0.001
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.987471e-01	0.001
Synthesis of bile acids and bile salts	R-HSA-192105	9.988513e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.989311e-01	0.000
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.989311e-01	0.000
Collagen degradation	R-HSA-1442490	9.990269e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.990718e-01	0.000
Complex I biogenesis	R-HSA-6799198	9.992044e-01	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	9.993055e-01	0.000
O-linked glycosylation of mucins	R-HSA-913709	9.995193e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.995863e-01	0.000
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.996447e-01	0.000
Metal ion assimilation from the host	R-HSA-9638482	9.996447e-01	0.000
Metabolism of cofactors	R-HSA-8978934	9.996447e-01	0.000
Collagen formation	R-HSA-1474290	9.996718e-01	0.000
Purine catabolism	R-HSA-74259	9.996788e-01	0.000
Citric acid cycle (TCA cycle)	R-HSA-71403	9.997626e-01	0.000
Signaling by GPCR	R-HSA-372790	9.998054e-01	0.000
SLC-mediated transport of organic anions	R-HSA-9955298	9.998246e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.998247e-01	0.000
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.998414e-01	0.000
Phospholipid metabolism	R-HSA-1483257	9.998595e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.998791e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.999042e-01	0.000
Sulfur amino acid metabolism	R-HSA-1614635	9.999292e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999424e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999501e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999566e-01	0.000
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.999742e-01	0.000
Scavenging of heme from plasma	R-HSA-2168880	9.999767e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.999789e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.999828e-01	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999849e-01	0.000
Bacterial Infection Pathways	R-HSA-9824439	9.999861e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.999884e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999887e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999896e-01	0.000
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999915e-01	0.000
Keratinization	R-HSA-6805567	9.999918e-01	0.000
Sensory perception of taste	R-HSA-9717189	9.999941e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999949e-01	0.000
Transport of small molecules	R-HSA-382551	9.999949e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999958e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999964e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999982e-01	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	9.999990e-01	0.000
Arachidonate metabolism	R-HSA-2142753	9.999993e-01	0.000
Drug ADME	R-HSA-9748784	9.999994e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.999995e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999998e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999998e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.999998e-01	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	9.999998e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000