CAMK2G

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A4FU28 S138 Sugiyama CTAGE9 EKAAAEEARSLEATCEKLSRsNsELEDEILCLEKDLKEEKS
A5A3E0 S939 Sugiyama POTEF A26C1B VALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPE
A5A3E0 Y940 Sugiyama POTEF A26C1B ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
O00273 S28 Sugiyama DFFA DFF1 DFF45 H13 GVPESGEIRTLKPCLLRRNysREQHGVAAsCLEDLRSKACD
O00488 S124 Sugiyama ZNF593 ZT86 RAAGMGSYVPPRRLAVPTEVsTEVPEMDtst__________
O00488 S93 Sugiyama ZNF593 ZT86 STNLKTHFRSKDHKKRLKQLsVEPysQEEAERAAGMGSYVP
O00488 S98 Sugiyama ZNF593 ZT86 THFRSKDHKKRLKQLsVEPysQEEAERAAGMGSYVPPRRLA
O00488 Y97 Sugiyama ZNF593 ZT86 KTHFRSKDHKKRLKQLsVEPysQEEAERAAGMGSYVPPRRL
O14618 S197 Sugiyama CCS GRAIFRMEDEQLKVWDVIGRsLIIDEGEDDLGRGGHPLSKI
O14639 S452 Sugiyama ABLIM1 ABLIM KIAA0059 LIMAB1 PtPsAEGyQDVRDRMIHRstsQGsINsPVySRHsYtPTTSR
O14974 S910 Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O14974 S995 Sugiyama PPP1R12A MBS MYPT1 ADRSLLEMEKRERRALERRIsEMEEELKMLPDLKADNQRLK
O15067 S215 Sugiyama PFAS KIAA0361 LDSWDLDFYTKRFQELQRNPstVEAFDLAQsNsEHSRHWFF
O15212 T38 Sugiyama PFDN6 HKE2 PFD6 QLQKDLSKSMSGRQKLEAQLtENNIVKEELALLDGsNVVFK
O15460 S531 Sugiyama P4HA2 UNQ290/PRO330 KWVSNKWFHERGQEFLRPCGstEVD________________
O43164 S253 Sugiyama PJA2 KIAA0438 RNF131 LDsVPLVKssAGDTEFVHQNsQEIQRSSQDEMVSTKQQNNT
O43290 S521 Sugiyama SART1 KQLEKGRRLRQLQQLQQLRDsGEKVVEIVKKLESRQRGWEE
O43399 S166 Sugiyama TPD52L2 tVGsAIsRKLGDMRNsAtFKsFEDRVGtIKSKVVGDRENGs
O43399 T163 Sugiyama TPD52L2 ALstVGsAIsRKLGDMRNsAtFKsFEDRVGtIKSKVVGDRE
O43423 S100 Sugiyama ANP32CP PP32R1 AEKCPNLTHLYLSGNKIKDLstIEPLKQLENLKSLDLFNCE
O43707 T69 Sugiyama ACTN4 EKQQRKTFTAWCNsHLRKAGtQIENIDEDFRDGLKLMLLLE
O43823 S323 Sugiyama AKAP8 AKAP95 RKRKQFQLyEEPDtKLARVDsEGDFsENDDAAGDFRsGDEE
O43852 S44 Sugiyama CALU KKDRVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQL
O43852 T196 Sugiyama CALU FtAFLHPEEyDyMKDIVVQEtMEDIDKNADGFIDLEEyIGD
O60220 S94 Sugiyama TIMM8A DDP DDP1 TIM8A SQFILNRLEQTQKSKPVFSEsLsD_________________
O60266 S1076 SIGNOR|iPTMNet ADCY3 KIAA0511 ARKPHYDIWGNTVNVASRMEsTGVMGNIQVVEETQVILREY
O60282 S176 Sugiyama KIF5C KIAA0531 NKHC2 VHEDKNRVPYVKGCTERFVSsPEEVMDVIDEGKANRHVAVT
O60343 S588 Sugiyama TBC1D4 AS160 KIAA0603 tssLENIFSRGANRMRGRLGsVDsFERsNsLASEKDYsPGD
O60343 S591 Sugiyama TBC1D4 AS160 KIAA0603 LENIFSRGANRMRGRLGsVDsFERsNsLASEKDYsPGDsPP
O60664 S148 Sugiyama PLIN3 M6PRBP1 TIP47 KVsGAQEMVssAKDTVAtQLsEAVDATRGAVQSGVDKTKsV
O60749 S365 Sugiyama SNX2 TRG9 AKSAAMLGNsEDHTALSRALsQLAEVEEKIDQLHQEQAFAD
O60841 S107 Sugiyama EIF5B IF2 KIAA0741 NEEEFtsKDKKKKGQKGKKQsFDDNDsEELEDKDsKSKKTA
O60841 S182 Sugiyama EIF5B IF2 KIAA0741 DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O60841 S190 Sugiyama EIF5B IF2 KIAA0741 NsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKNKPGP
O60841 S66 Sugiyama EIF5B IF2 KIAA0741 KEKKKQDFDEDDILKELEELsLEAQGIKADREtVAVKPTEN
O60927 T75 Sugiyama PPP1R11 HCGV TCTE5 RRssKCCCIyEKPRAFGEsstEsDEEEEEGCGHtHCVRGHR
O75128 S1171 Sugiyama COBL KIAA0633 SALLAAIRGHSGTCSLRKVAsSAsEELQSFRDAALSAQGSE
O75534 T761 Sugiyama CSDE1 D1S155E KIAA0885 NRU UNR GPKAVAAPRPDRLVNRLKNItLDDAsAPRLMVLRQPRGPDN
O75821 S189 Sugiyama EIF3G EIF3S4 CPYKDtLGPMQKELAEQLGLstGEKEKLPGELEPVQAtQNK
O76070 S9 Sugiyama SNCG BCSG1 PERSYN PRSN ____________MDVFKKGFsIAKEGVVGAVEKTKQGVTEA
O94761 S27 Sugiyama RECQL4 RECQ4 VRERLQAWERAFRRQRGRRPsQDDVEAAPEETRALYREYRT
O94992 S268 Sugiyama HEXIM1 CLP1 EDG1 HIS1 MAQ1 EDGGsDGMGGDGSEFLQRDFsEtyERyHTEsLQNMsKQELI
O94992 T270 Sugiyama HEXIM1 CLP1 EDG1 HIS1 MAQ1 GGsDGMGGDGSEFLQRDFsEtyERyHTEsLQNMsKQELIKE
O95071 S327 Sugiyama UBR5 EDD EDD1 HYD KIAA0896 LLRERESVLRLRERRWLDGAsFDNERGSTSKEGEPNLDKKN
O95155 S105 Sugiyama UBE4B HDNB1 KIAA0684 UFD2 LsssPsNsLEtQsQsLsRsQsMDIDGVSCEKsMsQVDVDsG
O95180 S1198 PSP CACNA1H EAEDGRAAPGPRATPLRRAEsLDPRPLRPAALPPTKCRDRD
O95197 S316 Sugiyama RTN3 ASYIP NSPL2 PLRNKEAGRYPMSALLSRQFsHtNAALEEVSRCVNDMHNFT
O95218 S120 Sugiyama ZRANB2 ZIS ZNF265 tGYGGGFNERENVEyIEREEsDGEyDEFGRKKKKYRGKAVG
O95218 S153 Sugiyama ZRANB2 ZIS ZNF265 KYRGKAVGPAsILKEVEDKEsEGEEEDEDEDLsKyKLDEDE
O95218 S188 Sugiyama ZRANB2 ZIS ZNF265 KLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRRSRSKSRS
O95425 S914 Sugiyama SVIL LRTKPPLDHNAsAtDYKFSssIENsDsPVRSILKSQAWQPL
O95425 S968 Sugiyama SVIL GETESKRALTGRDSGMEKyGsFEEAEASYPILNRAREGDSH
O95626 S104 Sugiyama ANP32D PP32R2 AEKCPNLIHLNLSGNKIKDLstIEPLKKLENLESLDLFTCE
O95678 S162 Sugiyama KRT75 K6HF KB18 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
O95816 S31 Sugiyama BAG2 NEGRFCRsssMADRsSRLLEsLDQLELRVEALREAATAVEQ
O96013 S41 Sugiyama PAK4 KIAA1142 VHTGFDQHEQKFTGLPRQWQsLIEESARRPKPLVDPACITS
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00533 S1070 SIGNOR|iPTMNet EGFR ERBB ERBB1 HER1 IDRNGLQsCPIKEDsFLQRyssDPtGALtEDsIDDtFLPVP
P00533 S1071 SIGNOR|iPTMNet EGFR ERBB ERBB1 HER1 DRNGLQsCPIKEDsFLQRyssDPtGALtEDsIDDtFLPVPE
P00558 S399 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 CCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDALsNI__
P00558 T394 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 GDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDAL
P02538 S176 Sugiyama KRT6A K6A KRT6D IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04083 S189 Sugiyama ANXA1 ANX1 LPC1 tsDtsGDFRNALLsLAKGDRsEDFGVNEDLADsDARALyEA
P04083 T169 Sugiyama ANXA1 ANX1 LPC1 IRDINRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRs
P04259 S176 Sugiyama KRT6B K6B KRTL1 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792 S15 Sugiyama HSPB1 HSP27 HSP28 ______MTERRVPFsLLRGPsWDPFRDWyPHsRLFDQAFGL
P04792 S78 Sugiyama HSPB1 HSP27 HSP28 LPPAAIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVs
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04792 S83 Sugiyama HSPB1 HSP27 HSP28 IEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNH
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05387 S29 Sugiyama RPLP2 D11S2243E RPP2 LAALGGNssPsAKDIKKILDsVGIEADDDRLNKVIsELNGK
P05423 S250 Sugiyama POLR3D BN51 BN51T AKMKAPPKAARKTPGLPKDVsVAELLRELSLTKEEELLFLQ
P05783 S305 Sugiyama KRT18 CYK18 PIG46 QSAEVGAAETTLTELRRtVQsLEIDLDsMRNLKAsLENsLR
P05787 S104 Sugiyama KRT8 CYK8 IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P05787 S291 Sugiyama KRT8 CYK8 ANRsRAEAEsMyQIKyEELQsLAGKHGDDLRRTKTEISEMN
P05787 S477 Sugiyama KRT8 CYK8 SSRAVVVKKIETRDGKLVsEssDVLPK______________
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07101 S19 SIGNOR|iPTMNet TH TYH __MPTPDATTPQAKGFRRAVsELDAKQAEAIMVRGQGAPGP
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 S320 Sugiyama LDHB GLtsVINQKLKDDEVAQLKKsADtLWDIQKDLKDL______
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07205 S399 Sugiyama PGK2 PGKB CCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEALSNM__
P07205 T394 Sugiyama PGK2 PGKB GDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEAL
P07237 S427 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB WDKLGEtyKDHENIVIAKMDstANEVEAVKVHsFPtLKFFP
P07355 S184 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK
P07737 T65 Sugiyama PFN1 PAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQDGEFs
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900 S399 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNLVKK
P07900 S468 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA GIHEDsQNRKKLsELLRyytsAsGDEMVsLKDYCTRMKENQ
P07900 S52 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900 S53 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P07900 S63 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPN
P07900 T195 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DTGEPMGRGTKVILHLKEDQtEyLEERRIKEIVKKHSQFIG
P07900 T305 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IDQEELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLA
P07900 T88 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA sKLDsGKELHINLIPNKQDRtLtIVDtGIGMTKADLINNLG
P07900 T90 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LDsGKELHINLIPNKQDRtLtIVDtGIGMTKADLINNLGtI
P08238 S391 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNIVKK
P08238 S45 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 S48 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08238 S58 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPN
P08238 T190 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
P08238 T297 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IDQEELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLA
P08238 T459 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB LGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEt
P08238 T467 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB NRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyIt
P08238 Y457 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB LKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMK
P08621 S410 Sugiyama SNRNP70 RNPU1Z RPU1 SNRP70 U1AP1 DEARGGGGGQDNGLEGLGNDsRDMYMESEGGDGYLAPENGY
P08729 S104 Sugiyama KRT7 SCL LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P09234 S48 Sugiyama SNRPC RKHKENVKDYYQKWMEEQAQsLIDKTTAAFQQGKIPPTPFS
P09382 S63 Sugiyama LGALS1 CLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVFPFQPG
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P0CG41 S138 Sugiyama CTAGE8 EKAAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKS
P10412 S89 Sugiyama H1-4 H1F4 HIST1H1E AGyDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P10412 T92 Sugiyama H1-4 H1F4 HIST1H1E DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P11532 S3623 Sugiyama DMD EAKVNGttVssPstsLQRsDssQPMLLRVVGSQTSDSMGEE
P11717 S1378 Sugiyama IGF2R MPRI QYACPPFDLTECSFKDGAGNsFDLsSLSRYSDNWEAITGTG
P12035 S211 Sugiyama KRT3 IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P12268 S416 Sugiyama IMPDH2 IMPD2 APGEYFFSDGIRLKKyRGMGsLDAMDKHLssQNRyFsEADK
P12956 S477 Sugiyama XRCC6 G22P1 EQVGKMKAIVEKLRFtYRsDsFENPVLQQHFRNLEALALDL
P13073 S74 Sugiyama COX4I1 COX4 HLSASQKALKEKEKASWssLsMDEKVELYRIKFKEsFAEMN
P13073 S89 Sugiyama COX4I1 COX4 SWssLsMDEKVELYRIKFKEsFAEMNRGSNEWKTVVGGAMF
P13639 T5 Sugiyama EEF2 EF2 ________________MVNFtVDQIRAIMDKKANIRNMsVI
P13647 S181 Sugiyama KRT5 IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314 S168 Sugiyama PRKCSH G19P1 WKKAREEKQKKLIELQAGKKsLEDQVEMLRTVKEEAEKPER
P14625 S106 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625 S109 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P14625 S514 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK
P14625 S515 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 GVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQ
P15311 S535 Sugiyama EZR VIL2 EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15311 S539 Sugiyama EZR VIL2 TEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNENMR
P15336 S62 Sugiyama ATF2 CREB2 CREBP1 LAVHKHKHEMtLKFGPARNDsVIVADQtPtPtRFLKNCEEV
P15531 S120 Sugiyama NME1 NDPKA NM23 KPGtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELV
P15531 S122 Sugiyama NME1 NDPKA NM23 GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P15531 S44 Sugiyama NME1 NDPKA NM23 IIKRFEQKGFRLVGLKFMQAsEDLLKEHyVDLKDRPFFAGL
P16070 S71 Sugiyama CD44 LHR MDU2 MDU3 MIC4 DLCKAFNSTLPTMAQMEKALsIGFEtCRyGFIEGHVVIPRI
P16401 S92 Sugiyama H1-5 H1F5 HIST1H1B GGYDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P16401 T95 Sugiyama H1-5 H1F5 HIST1H1B DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P16402 S90 Sugiyama H1-3 H1F3 HIST1H1D AGyDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P16402 T93 Sugiyama H1-3 H1F3 HIST1H1D DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P16403 S89 Sugiyama H1-2 H1F2 HIST1H1C AGyDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P16403 T92 Sugiyama H1-2 H1F2 HIST1H1C DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P16949 S16 GPS6 STMN1 C1orf215 LAP18 OP18 _____MAssDIQVKELEKRAsGQAFELILsPRsKEsVPEFP
P17096 S102 Sugiyama HMGA1 HMGIY KPRGRPKKLEKEEEEGIsQEssEEEQ_______________
P17544 S44 Sugiyama ATF7 ATFA LAVHKHKHEMTLKFGPARtDsVIIADQtPtPtRFLKNCEEV
P17600 S568 SIGNOR|iPTMNet SYN1 PPAsPsPQRQAGPPQATRQTsVSGPAPPKASGAPPGGQQRQ
P17600 S605 SIGNOR|iPTMNet SYN1 QQRQGPPQKPPGPAGPTRQAsQAGPVPRTGPPTTQQPRPSG
P17987 S544 Sugiyama TCP1 CCT1 CCTA ILRIDDLIKLHPESKDDKHGsyEDAVHsGALND________
P18615 S115 Sugiyama NELFE RD RDBP KLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLyEs
P18615 S135 Sugiyama NELFE RD RDBP sADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEG
P18615 S51 Sugiyama NELFE RD RDBP ALKKQSSSSTTSQGGVKRsLsEQPVMDTATATEQAKQLVKS
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P18669 S152 Sugiyama PGAM1 PGAMA CDABP0006 FysNIsKDRRyADLtEDQLPsCEsLKDtIARALPFWNEEIV
P18846 S63 SIGNOR|iPTMNet ATF1 DsSDsIGssQKAHGILARRPsYRKILKDLsSEDTRGRKGDG
P18859 S57 Sugiyama ATP5PF ATP5A ATP5J ATPM DPIQKLFVDKIREYKSKRQTsGGPVDAssEyQQELERELFK
P19338 S328 Sugiyama NCL NLFVGNLNFNKSAPELKtGIsDVFAKNDLAVVDVRIGMTRK
P19338 S356 Sugiyama NCL LAVVDVRIGMTRKFGyVDFEsAEDLEKALELtGLKVFGNEI
P19338 S458 Sugiyama NCL TEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKN
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19338 S580 Sugiyama NCL PRGsPNARSQPSKTLFVKGLsEDttEEtLKEsFDGsVRARI
P19338 S619 Sugiyama NCL RIVTDRETGssKGFGFVDFNsEEDAKAAKEAMEDGEIDGNK
P19338 Y463 Sugiyama NCL EKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNSTWsG
P20042 S67 Sugiyama EIF2S2 EIF2B EPtEDKDLEADEEDTRKKDAsDDLDDLNFFNQKKKKKKTKK
P20290 S173 Sugiyama BTF3 NACB OK/SW-cl.8 QLGADsLtsLRRLAEALPKQsVDGKAPLAtGEDDDDEVPDL
P21333 S2523 SIGNOR FLNA FLN FLN1 GPYHIGGsPFKAKVTGPRLVsNHsLHEtsSVFVDsLtKATC
P21817 S2843 SIGNOR|iPTMNet RYR1 RYDR IEKAREGEEEKTEKKKTRKIsQsAQtyDPREGYNPQPPDLS
P22090 S204 Sugiyama RPS4Y1 RPS4Y PRO2646 IGGANLGRVGVITNRERHPGsFDVVHVKDANGNSFATRLSN
P22314 S46 Sugiyama UBA1 A1S9T UBE1 AQsVLsEVPSVPTNGMAKNGsEADIDEGLysRQLyVLGHEA
P22626 S189 Sugiyama HNRNPA2B1 HNRPA2B1 IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P22626 S212 Sugiyama HNRNPA2B1 HNRPA2B1 EMQEVQssRsGRGGNFGFGDsRGGGGNFGPGPGsNFRGGsD
P22626 T140 Sugiyama HNRNPA2B1 HNRPA2B1 KEDTEEHHLRDyFEEYGKIDtIEIItDRQsGKKRGFGFVtF
P23528 S41 Sugiyama CFL1 CFL RKsstPEEVKKRKKAVLFCLsEDKKNIILEEGKEILVGDVG
P23528 T63 Sugiyama CFL1 CFL DKKNIILEEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyA
P23528 T70 Sugiyama CFL1 CFL EEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyALyDAtyE
P23588 S122 Sugiyama EIF4B NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P23588 S131 Sugiyama EIF4B SIKEFFRGLNIsAVRLPREPsNPERLKGFGyAEFEDLDSLL
P23588 S207 Sugiyama EIF4B DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P23588 S597 Sugiyama EIF4B KKPEENPASKFssASKyAALsVDGEDENEGEDyAE______
P24534 S141 Sugiyama EEF1B2 EEF1B EF1B ERLAQYESKKAKKPALVAKssILLDVKPWDDEtDMAKLEEC
P25054 S1389 Sugiyama APC DP2.5 PKsPPEHYVQETPLMFsRCTsVSsLDSFESRSIASSVQSEP
P25054 S2129 Sugiyama APC DP2.5 NSIVSSLHQAAAAACLsRQAssDSDSILSLKsGIsLGsPFH
P25705 S65 Sugiyama ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM KtGtAEMssILEERILGADtsVDLEETGRVLsIGDGIARVH
P26038 S527 Sugiyama MSN ERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHAE
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P26038 T526 Sugiyama MSN EERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHA
P26358 S91 Sugiyama DNMT1 AIM CXXC9 DNMT EELSEEGYLAKVKSLLNKDLsLENGAHAYNREVNGRLENGN
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373 S97 Sugiyama RPL13 BBC1 OK/SW-cl.46 sLEELRVAGIHKKVARTIGIsVDPRRRNKstEsLQANVQRL
P26373 T107 Sugiyama RPL13 BBC1 OK/SW-cl.46 HKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILF
P26373 T148 Sugiyama RPL13 BBC1 OK/SW-cl.46 PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373 T151 Sugiyama RPL13 BBC1 OK/SW-cl.46 PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P26641 T287 Sugiyama EEF1G EF1G PRO1608 EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P27348 S45 Sugiyama YWHAQ CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27797 S53 Sugiyama CALR CRTC WtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDAR
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P27987 S174 PSP ITPKB IQAQssAIQAPRsPRLGRARsPsPCPFRSSSQPPGRVLVQG
P28329 T574 SIGNOR CHAT YESAsIRRFQEGRVDNIRSAtPEALAFVRAVTDHKAAVPAs
P28340 S1064 Sugiyama POLD1 POLD LNALEERFSRLWTQCQRCQGsLHEDVICTSRDCPIFyMRKK
P29692 S86 Sugiyama EEF1D EF1D GPGAssGtsGDHGELVVRIAsLEVENQsLRGVVQELQQAIs
P30040 T62 Sugiyama ERP29 C12orf8 ERP28 DtVtFyKVIPKSKFVLVKFDtQyPyGEKQDEFKRLAENSAS
P30043 T190 Sugiyama BLVRB FLR SCAN RGPSRVISKHDLGHFMLRCLttDEyDGHstyPsHQyQ____
P30050 S138 Sugiyama RPL12 HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30050 S157 Sugiyama RPL12 QsVGCNVDGRHPHDIIDDINsGAVECPAs____________
P30086 S52 Sugiyama PEBP1 PBP PEBP AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P30086 S54 Sugiyama PEBP1 PBP PEBP VDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPDAP
P30101 T485 Sugiyama PDIA3 ERP57 ERP60 GRP58 KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P30533 S242 Sugiyama LRPAP1 A2MRAP TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P30533 S247 Sugiyama LRPAP1 A2MRAP KLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWDLAQSA
P30533 Y246 Sugiyama LRPAP1 A2MRAP EKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWDLAQS
P30626 S111 Sugiyama SRI GFNEFKELWAVLNGWRQHFIsFDTDRSGTVDPQELQKALtt
P31943 S23 Sugiyama HNRNPH1 HNRPH HNRPH1 LGTEGGEGFVVKVRGLPWsCsADEVQRFFSDCKIQNGAQGI
P31946 S47 Sugiyama YWHAB AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947 S45 Sugiyama SFN HME1 FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P32119 S112 Sugiyama PRDX2 NKEFB TDPX1 KEGGLGPLNIPLLADVTRRLsEDyGVLKTDEGIAYRGLFII
P32119 S151 Sugiyama PRDX2 NKEFB TDPX1 IIDGKGVLRQItVNDLPVGRsVDEALRLVQAFQYTDEHGEV
P32119 T142 Sugiyama PRDX2 NKEFB TDPX1 EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P33527 S915 Sugiyama ABCC1 MRP MRP1 QMENGMLVTDsAGKQLQRQLsssssysGDISRHHNstAELQ
P34932 S363 Sugiyama HSPA4 APG2 HSPH2 GATRIPAVKEKISKFFGKELsttLNADEAVTRGCALQCAIL
P35241 S532 Sugiyama RDX EERVTETQKNERVKKQLQALssELAQARDETKKTQNDVLHA
P35241 S533 Sugiyama RDX ERVTETQKNERVKKQLQALssELAQARDETKKTQNDVLHAE
P35269 T154 Sugiyama GTF2F1 RAP74 AFEAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHF
P35269 T156 Sugiyama GTF2F1 RAP74 EAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHFSI
P35270 S213 SIGNOR|iPTMNet SPR VLNYAPGPLDTDMQQLARETsVDPDMRKGLQELKAKGKLVD
P35579 S1943 Sugiyama MYH9 RGDLPFVVPRRMARKGAGDGsDEEVDGKADGAEAKPAE___
P35637 S340 Sugiyama FUS TLS PMINLyTDRETGKLKGEAtVsFDDPPsAKAAIDWFDGKEFs
P35637 T338 Sugiyama FUS TLS GQPMINLyTDRETGKLKGEAtVsFDDPPsAKAAIDWFDGKE
P35908 S191 Sugiyama KRT2 KRT2A KRT2E IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P36578 S55 Sugiyama RPL4 RPL1 DIVNFVHTNLRKNNRQPyAVsELAGHQtsAEsWGtGRAVAR
P36578 S63 Sugiyama RPL4 RPL1 NLRKNNRQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGGG
P36578 S87 Sugiyama RPL4 RPL1 WGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAPTKT
P36578 T84 Sugiyama RPL4 RPL1 AEsWGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAP
P37108 T45 Sugiyama SRP14 sVyItLKKYDGRTKPIPKKGtVEGFEPADNKCLLRATDGKK
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P38646 T398 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39023 S304 Sugiyama RPL3 OK/SW-cl.32 IYKIGQGyLIKDGKLIKNNAstDyDLSDKSINPLGGFVHYG
P39687 S104 Sugiyama ANP32A C15orf1 LANP MAPM PHAP1 AEKCPNLTHLNLsGNKIKDLstIEPLKKLENLKsLDLFNCE
P39687 S117 Sugiyama ANP32A C15orf1 LANP MAPM PHAP1 GNKIKDLstIEPLKKLENLKsLDLFNCEVtNLNDyRENVFK
P39687 T143 Sugiyama ANP32A C15orf1 LANP MAPM PHAP1 CEVtNLNDyRENVFKLLPQLtyLDGyDRDDKEAPDsDAEGY
P40818 S719 Sugiyama USP8 KIAA0055 UBPY KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P41091 T464 Sugiyama EIF2S3 EIF2G SRRVEKHWRLIGWGQIRRGVtIKPtVDDD____________
P41091 T468 Sugiyama EIF2S3 EIF2G EKHWRLIGWGQIRRGVtIKPtVDDD________________
P41236 S121 Sugiyama PPP1R2 IPP2 ARKLAAAEGLEPKyRIQEQEssGEEDsDLsPEEREKKRQFE
P42224 S727 SIGNOR STAT1 IsVsEVHPSRLQttDNLLPMsPEEFDEVSRIVGsVEFDSMM
P42261 S645 SIGNOR|iPTMNet GRIA1 GLUA1 GLUH1 GLUR1 IIISSYTANLAAFLTVERMVsPIESAEDLAKQTEIAYGTLE
P42261 S849 SIGNOR|iPTMNet GRIA1 GLUA1 GLUH1 GLUR1 CYKsRsEsKRMKGFCLIPQQsINEAIRTStLPRNsGAGASS
P42677 S78 Sugiyama RPS27 MPS1 GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P43034 S152 Sugiyama PAFAH1B1 LIS1 MDCR MDS PAFAHA IKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADM
P43034 S157 Sugiyama PAFAH1B1 LIS1 MDCR MDS PAFAHA yEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADMTIKLW
P43034 S399 Sugiyama PAFAH1B1 LIS1 MDCR MDS PAFAHA HEHFVTSLDFHKTAPYVVTGsVDQTVKVWECR_________
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46013 S1098 Sugiyama MKI67 PAARVTGMKKWPRtPKEEAQsLEDLAGFKELFQtPGPsEEs
P46013 T1764 Sugiyama MKI67 LVDtPtssKPQPKRSLRKADtEEEFLAFRKQTPSAGKAMHt
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46937 S109 Sugiyama YAP1 YAP65 RKLPDsFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssP
P46937 T114 Sugiyama YAP1 YAP65 sFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssPAsLQL
P47756 T202 Sugiyama CAPZB SGsGtMNLGGsLtRQMEKDEtVsDCsPHIANIGRLVEDMEN
P48058 S862 SIGNOR|iPTMNet GRIA4 GluA4 GLUR4 AEAKRMKLtFSEAIRNKARLsITGSVGENGRVLTPDCPKAV
P48668 S176 Sugiyama KRT6C KRT6E IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P49736 S139 Sugiyama MCM2 BM28 CCNL1 CDCL1 KIAA0030 QRDREAGRGLGRMRRGLLyDsDEEDEERPARKRRQVERAtE
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51116 T598 Sugiyama FXR2 FMR1L2 DESRPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRA
P51116 T610 Sugiyama FXR2 FMR1L2 RRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQsRQRPPLER
P52272 S528 Sugiyama HNRNPM HNRPM NAGR1 IERMGsGVERMGPAIERMGLsMERMVPAGMGAGLERMGPVM
P52272 S618 Sugiyama HNRNPM HNRPM NAGR1 PALGAGIERMGLAMGGGGGAsFDRAIEMERGNFGGsFAGsF
P52298 S13 Sugiyama NCBP2 CBP20 PIG55 ________MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQE
P52597 S187 Sugiyama HNRNPF HNRPF KALGKHKERIGHRYIEVFKssQEEVRsysDPPLKFMsVQRP
P52943 S115 Sugiyama CRIP2 CRP2 AARAEERKAsGPPKGPsRAssVttFtGEPNtCPRCSKKVYF
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53999 S118 Sugiyama SUB1 PC4 RPO2TC1 PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P53999 S12 Sugiyama SUB1 PC4 RPO2TC1 _________MPKSKELVsssssGsDsDsEVDKKLKRKKQVA
P53999 S56 Sugiyama SUB1 PC4 RPO2TC1 PVKKQKTGETsRALsssKQssssRDDNMFQIGKMRYVSVRD
P55042 S273 SIGNOR|iPTMNet RRAD RAD LRRDsKEANARRQAGTRRREsLGKKAKRFLGRIVARNsRKM
P55055 S426 PSP NR1H2 LXRB NER UNR TRIKRPQDQLRFPRMLMKLVsLRTLsSVHSEQVFALRLQDK
P55081 S132 Sugiyama MFAP1 VVGEsDsEVEGDAWRMEREDssEEEEEEIDDEEIERRRGMM
P55081 S133 Sugiyama MFAP1 VGEsDsEVEGDAWRMEREDssEEEEEEIDDEEIERRRGMMR
P55196 S424 Sugiyama AFDN AF6 MLLT4 HTYEDGSDSRDKPKLYRLQLsVtEVGTEKLDDNSIQLFGPG
P60174 S198 Sugiyama TPI1 TPI TPQQAQEVHEKLRGWLKsNVsDAVAQstRIIyGGsVtGAtC
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60174 S97 Sugiyama TPI1 TPI GEIsPGMIKDCGAtWVVLGHsERRHVFGEsDELIGQKVAHA
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S239 Sugiyama ACTB VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 Y240 Sugiyama ACTB ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P61247 S236 Sugiyama RPS3A FTE1 MFTL KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61247 S238 Sugiyama RPS3A FTE1 MFTL LKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGyEP
P61254 T8 Sugiyama RPL26 _____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61353 S86 Sugiyama RPL27 SKIKSFVKVyNyNHLMPtRysVDIPLDKtVVNKDVFRDPAL
P61916 S29 Sugiyama NPC2 HE1 LLLALSTAAQAEPVQFKDCGsVDGVIKEVNVsPCPtQPCQL
P61978 S417 Sugiyama HNRNPK HNRPK DLAGsIIGKGGQRIKQIRHEsGAsIKIDEPLEGsEDRIITI
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981 S46 Sugiyama YWHAG AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P61981 T31 Sugiyama YWHAG ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P62072 S48 Sugiyama TIMM10 TIM10 ACHRKCVPPHYKEAELSKGEsVCLDRCVSKYLDIHERMGKK
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62258 S46 Sugiyama YWHAE SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62258 T229 Sugiyama YWHAE LsEEsyKDstLIMQLLRDNLtLWtsDMQGDGEEQNKEALQD
P62258 T232 Sugiyama YWHAE EsyKDstLIMQLLRDNLtLWtsDMQGDGEEQNKEALQDVED
P62269 S96 Sugiyama RPS18 D6S218E QYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLKK
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280 T15 Sugiyama RPS11 ______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62701 S204 Sugiyama RPS4X CCG2 RPS4 SCAR tGGANLGRIGVITNRERHPGsFDVVHVKDANGNSFATRLsN
P62736 S241 Sugiyama ACTA2 ACTSA ACTVS GIG46 VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 Y242 Sugiyama ACTA2 ACTSA ACTVS GIG46 ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62826 T66 Sugiyama RAN ARA24 OK/SW-cl.81 EVHPLVFHTNRGPIKFNVWDtAGQEKFGGLRDGYYIQAQCA
P62857 S23 Sugiyama RPS28 TSRVQPIKLARVTKVLGRtGsQGQCtQVRVEFMDDtsRsII
P62857 T28 Sugiyama RPS28 PIKLARVTKVLGRtGsQGQCtQVRVEFMDDtsRsIIRNVKG
P62899 S15 Sugiyama RPL31 ______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62899 T119 Sugiyama RPL31 PNKLytLVtyVPVttFKNLQtVNVDEN______________
P62899 T22 Sugiyama RPL31 APAKKGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRA
P62899 T26 Sugiyama RPL31 KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62906 S64 Sugiyama RPL10A NEDD6 QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 S138 Sugiyama RPL8 EKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVI
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62942 S68 Sugiyama FKBP1A FKBP1 FKBP12 KFMLGKQEVIRGWEEGVAQMsVGQRAKLTISPDYAYGATGH
P62942 T22 Sugiyama FKBP1A FKBP1 FKBP12 GVQVEtIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRD
P62979 S123 Sugiyama RPS27A UBA80 UBCEP1 LKYYKVDENGKIsRLRRECPsDECGAGVFMAsHFDRHyCGK
P62979 S134 Sugiyama RPS27A UBA80 UBCEP1 IsRLRRECPsDECGAGVFMAsHFDRHyCGKCCLtyCFNKPE
P63104 S45 Sugiyama YWHAZ CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63220 S31 Sugiyama RPS21 LYVPRKCSASNRIIGAKDHAsIQMNVAEVDKVTGRFNGQFK
P63220 S65 Sugiyama RPS21 RFNGQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF__
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S239 Sugiyama ACTG1 ACTG VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 Y240 Sugiyama ACTG1 ACTG ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63267 S240 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 Y241 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P67809 S102 Sugiyama YBX1 NSEP1 YB1 EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P67809 T108 Sugiyama YBX1 NSEP1 YB1 QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P67809 T80 Sugiyama YBX1 NSEP1 YB1 LGTVKWFNVRNGyGFINRNDtKEDVFVHQtAIKKNNPRKyL
P67809 Y99 Sugiyama YBX1 NSEP1 YB1 DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
P68032 S241 Sugiyama ACTC1 ACTC VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 Y242 Sugiyama ACTC1 ACTC ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68133 S241 Sugiyama ACTA1 ACTA VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 Y242 Sugiyama ACTA1 ACTA ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P83731 S38 Sugiyama RPL24 GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P83731 S86 Sugiyama RPL24 EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098 S12 Sugiyama RPL19 _________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
P84098 S37 Sugiyama RPL19 CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
P84098 T29 Sugiyama RPL19 RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
P98082 S723 EPSD|PSP|Sugiyama DAB2 DOC2 DANQLLNKINEPPKPAPRQVsLPVTKstDNAFENPFFKDsF
Q00688 S34 Sugiyama FKBP3 FKBP25 QLRSEQLPKKDIIKFLQEHGsDsFLAEHKLLGNIKNVAKTA
Q00688 S36 Sugiyama FKBP3 FKBP25 RSEQLPKKDIIKFLQEHGsDsFLAEHKLLGNIKNVAKTANK
Q00688 T11 Sugiyama FKBP3 FKBP25 __________MAAAVPQRAWtVEQLRSEQLPKKDIIKFLQE
Q00839 S59 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 QAALDDEEAGGRPAMEPGNGsLDLGGDsAGRSGAGLEQEAA
Q01105 S161 Sugiyama SET FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q01105 S166 Sugiyama SET yFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQT
Q01105 T169 Sugiyama SET NKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQNK
Q01546 S196 Sugiyama KRT76 KRT2B KRT2P IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q01650 S31 Sugiyama SLC7A5 CD98LC LAT1 MPE16 LAAPAAEEKEEAREKMLAAKsADGsAPAGEGEGVtLQRNIT
Q01970 S537 SIGNOR|iPTMNet PLCB3 PGLSNGEEVGLEKPSLEPQKsLGDEGLNRGPyVLGPADRED
Q02539 S92 Sugiyama H1-1 H1F1 HIST1H1A AGyDVEKNNSRIKLGIKsLVsKGtLVQtKGtGAsGsFKLNK
Q02539 T95 Sugiyama H1-1 H1F1 HIST1H1A DVEKNNSRIKLGIKsLVsKGtLVQtKGtGAsGsFKLNKKAS
Q04637 S1238 Sugiyama EIF4G1 EIF4F EIF4G EIF4GI RDAVKREAALPPVsPLKAALsEEELEKKsKAIIEEyLHLND
Q04917 S46 Sugiyama YWHAH YWHA1 AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q05397 S677 Sugiyama PTK2 FAK FAK1 KCWAYDPSRRPRFTELKAQLsTILEEEKAQQEERMRMEsRR
Q06210 S261 Sugiyama GFPT1 GFAT GFPT GsQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDA
Q06210 T262 Sugiyama GFPT1 GFAT GFPT sQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDAS
Q06830 S152 Sugiyama PRDX1 PAGA PAGB TDPX2 IIDDKGILRQItVNDLPVGRsVDEtLRLVQAFQFtDKHGEV
Q06830 T143 Sugiyama PRDX1 PAGA PAGB TDPX2 EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q06830 T156 Sugiyama PRDX1 PAGA PAGB TDPX2 KGILRQItVNDLPVGRsVDEtLRLVQAFQFtDKHGEVCPAG
Q07021 S210 Sugiyama C1QBP GC1QBP HABP1 SF2P32 EDEVGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDS
Q07157 S1051 Sugiyama TJP1 ZO1 PDKEPNLTyEPQLPYVEKQAsRDLEQPtyRyEsssytDQFs
Q08945 S657 Sugiyama SSRP1 FACT80 MEKKSTPSRGsSSKSsSRQLsEsFKSKEFVssDEsssGENK
Q08AD1 S1313 Sugiyama CAMSAP2 CAMSAP1L1 KIAA1078 sLNtGDNEsVHsGKRtPRsEsVEGFLsPsRCGsRNGEKDWE
Q08AD1 S464 Sugiyama CAMSAP2 CAMSAP1L1 KIAA1078 FDKEDSVQRstPNRGITRsIsNEGLtLNNsHVsKHIRKNLS
Q09028 S146 Sugiyama RBBP4 RBAP48 EVNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGE
Q12830 S1310 Sugiyama BPTF FAC1 FALZ DRVLDDVsIRsPEtKCPKQNsIENDIEEKVSDLASRGQEPS
Q13206 S831 Sugiyama DDX10 DMENKISDTKKKQGMKKRsNsEVEDVGPTsHNRKKARWDTL
Q13263 S473 Sugiyama TRIM28 KAP1 RNF96 TIF1B sGDDPyssAEPHVsGVKRsRsGEGEVsGLMRKVPRVsLERL
Q13283 S250 Sugiyama G3BP1 G3BP sssPAPADIAQtVQEDLRtFsWAsVtsKNLPPSGAVPVTGI
Q13283 S253 Sugiyama G3BP1 G3BP PAPADIAQtVQEDLRtFsWAsVtsKNLPPSGAVPVTGIPPH
Q13439 S41 Sugiyama GOLGA4 APAQAssNsstPtRMRsRtssFtEQLDEGtPNRESGDTQSF
Q13442 S176 Sugiyama PDAP1 HASPP28 KKEEERKAKDDATLsGKRMQsLsLNK_______________
Q13442 S19 Sugiyama PDAP1 HASPP28 __MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEEE
Q13442 S60 Sugiyama PDAP1 HASPP28 QKEGGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGVEGL
Q13442 S63 Sugiyama PDAP1 HASPP28 GGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGVEGLIDI
Q13442 T18 Sugiyama PDAP1 HASPP28 ___MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEE
Q13554 S26 Sugiyama CAMK2B CAM2 CAMK2 CAMKB TCTRFTDEYQLYEDIGKGAFsVVRRCVKLCTGHEYAAKIIN
Q13554 S280 Sugiyama CAMK2B CAM2 CAMK2 CAMKB RITAHEALKHPWVCQRstVAsMMHRQEtVECLKKFNARRKL
Q13554 T277 Sugiyama CAMK2B CAM2 CAMK2 CAMKB PAKRITAHEALKHPWVCQRstVAsMMHRQEtVECLKKFNAR
Q13555 S26 Sugiyama CAMK2G CAMK CAMK-II CAMKG TCTRFTDDYQLFEELGKGAFsVVRRCVKKTstQEYAAKIIN
Q13555 S280 EPSD|PSP|Sugiyama CAMK2G CAMK CAMK-II CAMKG RITADQALKHPWVCQRstVAsMMHRQEtVECLRKFNARRKL
Q13555 S311 Sugiyama CAMK2G CAMK CAMK-II CAMKG LRKFNARRKLKGAILttMLVsRNFsAAKsLLNKKSDGGVKK
Q13555 S319 EPSD|PSP CAMK2G CAMK CAMK-II CAMKG KLKGAILttMLVsRNFsAAKsLLNKKSDGGVKKRKsSSSVH
Q13555 T277 Sugiyama CAMK2G CAMK CAMK-II CAMKG PAKRITADQALKHPWVCQRstVAsMMHRQEtVECLRKFNAR
Q13555 T287 GPS6|EPSD CAMK2G CAMK CAMK-II CAMKG LKHPWVCQRstVAsMMHRQEtVECLRKFNARRKLKGAILtt
Q13555 T306 Sugiyama CAMK2G CAMK CAMK-II CAMKG EtVECLRKFNARRKLKGAILttMLVsRNFsAAKsLLNKKSD
Q13555 T307 Sugiyama CAMK2G CAMK CAMK-II CAMKG tVECLRKFNARRKLKGAILttMLVsRNFsAAKsLLNKKSDG
Q13557 S26 Sugiyama CAMK2D CAMKD TCTRFTDEyQLFEELGKGAFsVVRRCMKIPTGQEYAAKIIN
Q13557 S280 Sugiyama CAMK2D CAMKD RItAsEALKHPWICQRstVAsMMHRQEtVDCLKKFNARRKL
Q13557 T277 Sugiyama CAMK2D CAMKD PAKRItAsEALKHPWICQRstVAsMMHRQEtVDCLKKFNAR
Q13596 S368 Sugiyama SNX1 AKSLAMLGSSEDNTALSRALsQLAEVEEKIEQLHQEQANND
Q14151 S613 Sugiyama SAFB2 KIAA0138 ERSSKSQDRKSESKEKRDILsFDKIKEQRERERQRQREREI
Q14157 T241 Sugiyama UBAP2L KIAA0144 NICE4 TWNNTGHFEPDDGTSAWRtAtEEWGtEDWNEDLsEtKIFtA
Q14192 S238 Sugiyama FHL2 DRAL SLIM3 AKKCAGCTNPISGLGGtKyIsFEERQWHNDCFNCKKCsLsL
Q14247 S282 Sugiyama CTTN EMS1 QKDyKTGFGGKFGVQsERQDsAAVGFDyKEKLAKHEsQQDy
Q14524 S516 SIGNOR SCN5A KsDsEDGPRAMNHLsLTRGLsRTSMKPRssRGsIFTFRRRD
Q14524 S571 SIGNOR SCN5A AGESESHHTSLLVPWPLRRtsAQGQPsPGTSAPGHALHGKK
Q14524 T594 SIGNOR SCN5A GQPsPGTSAPGHALHGKKNStVDCNGVVSLLGAGDPEATSP
Q14568 S52 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14568 S53 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14676 T447 Sugiyama MDC1 KIAA0170 NFBD1 WNRDAEEDMPQRVVLLQRsQtttERDsDtDVEEEELPVENR
Q14676 T449 Sugiyama MDC1 KIAA0170 NFBD1 RDAEEDMPQRVVLLQRsQtttERDsDtDVEEEELPVENREA
Q14677 S163 Sugiyama CLINT1 ENTH EPN4 EPNR KIAA0171 DRLREERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSK
Q14677 S166 Sugiyama CLINT1 ENTH EPN4 EPNR KIAA0171 REERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSKWDE
Q14738 S598 Sugiyama PPP2R5D DVyTIKALEAHKRAEEFLTAsQEAL________________
Q14847 S99 Sugiyama LASP1 MLN50 ELQsQVRYKEEFEKNKGKGFsVVADtPELQRIKKTQDQIsN
Q14966 S1228 Sugiyama ZNF638 NP220 ZFML DLEKKGAEIINPKTALLPSDsVFAEERNLKGILEEsPsEAE
Q14978 S686 Sugiyama NOLC1 KIAA0035 NS5ATP13 KGKSFRHEKTKKKRGsYRGGsIsVQVNsIKFDsE_______
Q14978 S688 Sugiyama NOLC1 KIAA0035 NS5ATP13 KSFRHEKTKKKRGsYRGGsIsVQVNsIKFDsE_________
Q14CN4 S138 Sugiyama KRT72 K6IRS2 KB35 KRT6 KRT6IRS2 IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15003 S78 Sugiyama NCAPH BRRN BRRN1 CAPH KIAA0074 NDDEKERLQRRRsRVFDLQFstDsPRLLAsPsSRsIDIsAT
Q15036 S437 Sugiyama SNX17 KIAA0064 PLLEsPDAtREsMVKLSsKLsAVsLRGIGsPSTDASAsDVH
Q15036 S440 Sugiyama SNX17 KIAA0064 EsPDAtREsMVKLSsKLsAVsLRGIGsPSTDASAsDVHGNF
Q15121 S116 SIGNOR|iPTMNet PEA15 DtKLtRIPsAKKYKDIIRQPsEEEIIKLAPPPKKA______
Q15185 S113 Sugiyama PTGES3 P23 TEBP RAKLNWLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGD
Q15185 S82 Sugiyama PTGES3 P23 TEBP NDsKHKRtDRsILCCLRKGEsGQsWPRLTKERAKLNWLsVD
Q15293 S69 Sugiyama RCN1 RCN PPEDNQsFQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVD
Q15293 T71 Sugiyama RCN1 RCN EDNQsFQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVDRI
Q15398 T54 Sugiyama DLGAP5 DLG7 KIAA0008 NRHKEYERNRHFGLKDVNIPtLEGRILVELDETsQGLVPEK
Q15459 S690 Sugiyama SF3A1 SAP114 VHPPPPMEDEPTSKKLKTEDsLMPEEEFLRRNKGPVSIKVQ
Q15527 S183 Sugiyama SURF2 sDDsMtDLYPPELFTRKDLGstEDGDGtDDFLtDKEDEKAK
Q15527 T184 Sugiyama SURF2 DDsMtDLYPPELFTRKDLGstEDGDGtDDFLtDKEDEKAKP
Q15746 S1760 SIGNOR MYLK MLCK MLCK1 MYLK1 MARRKWQKTGNAVRAIGRLssMAMISGLSGRKsstGsPtsP
Q16204 S323 Sugiyama CCDC6 D10S170 TST1 RLQRKLQREMERREALCRQLsEsEssLEMDDERYFNEMsAQ
Q16204 S325 Sugiyama CCDC6 D10S170 TST1 QRKLQREMERREALCRQLsEsEssLEMDDERYFNEMsAQGL
Q16204 S327 Sugiyama CCDC6 D10S170 TST1 KLQREMERREALCRQLsEsEssLEMDDERYFNEMsAQGLRP
Q16513 S583 Sugiyama PKN2 PRK2 PRKCL2 VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs
Q16576 S145 Sugiyama RBBP7 RBAP46 EVNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGE
Q16625 S471 EPSD|PSP OCLN DEINKELSRLDKELDDYREEsEEyMAAADEYNRLKQVKGsA
Q16626 S163 Sugiyama MEA1 MEA RTMAGVSLPAPGVPAWAREIsDAQWEDVVQKALQARQAsPA
Q27J81 S1192 Sugiyama INF2 C14orf151 C14orf173 EDEDEEDtAPEsALDtsLDKsFsEDAVtDssGsGtLPRARG
Q2VIR3 T464 Sugiyama EIF2S3B SRRVEKHWRLIGWGQIRRGVtIKPtVDDD____________
Q2VIR3 T468 Sugiyama EIF2S3B EKHWRLIGWGQIRRGVtIKPtVDDD________________
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q3SY84 S143 Sugiyama KRT71 K6IRS1 KB34 KRT6IRS1 IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q562R1 S240 Sugiyama ACTBL2 VALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPE
Q562R1 Y241 Sugiyama ACTBL2 ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q58FF6 S34 Sugiyama HSP90AB4P IFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDIIPN
Q58FF6 T165 Sugiyama HSP90AB4P DHGEPIDRDTKVILHLKEDQtEyLEERWVKEVVKKHPQFIG
Q58FF7 S58 Sugiyama HSP90AB3P HSP90BC IFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FF7 T169 Sugiyama HSP90AB3P HSP90BC DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
Q58FF8 S58 Sugiyama HSP90AB2P HSP90BB IFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FG1 T28 Sugiyama HSP90AA4P HSP90AD HSPCAL2 SKLDSGKEPHISLIPNKQDRtLtIVDtGIGMTKADLINNLG
Q58FG1 T30 Sugiyama HSP90AA4P HSP90AD HSPCAL2 LDSGKEPHISLIPNKQDRtLtIVDtGIGMTKADLINNLGTI
Q5H9R7 S579 Sugiyama PPP6R3 C11orf23 KIAA1558 PP6R3 SAPL SAPS3 IDQFGFNDEKFADQDDIGNVsFDRVSDINFTLNTNESGNIA
Q5SW79 S881 Sugiyama CEP170 FAM68A KAB KIAA0470 sstPssLALtsAsRIRERsEsLDPDssMDTtLILKDTEAVM
Q5T035 T62 Sugiyama FAM120A2P C9orf129 yPysLSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyER
Q5TCZ1 S1038 Sugiyama SH3PXD2A FISH KIAA0418 SH3MD1 TKS5 FSTARSAAAEAKGRLAERAAsQGsDsPLLPAQRNsIPVsPV
Q5XKE5 S155 Sugiyama KRT79 K6L KB38 KRT6L IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q69YH5 S210 Sugiyama CDCA2 QSGFPAVLssKRRRIsYQRDsDENLTDAEGKVIGLQIFNID
Q6GYQ0 S797 Sugiyama RALGAPA1 GARNL1 KIAA0884 TULIP1 EtGNEVFGALNEEQPLPRssstsDILEPFTVERAKVNKEDM
Q6GYQ0 T798 Sugiyama RALGAPA1 GARNL1 KIAA0884 TULIP1 tGNEVFGALNEEQPLPRssstsDILEPFTVERAKVNKEDMS
Q6PKG0 S627 Sugiyama LARP1 KIAA0731 LARP FLFDEEMEQMDGRKNtFtAWsDEEsDyEIDDRDVNKILIVt
Q6S8J3 S939 Sugiyama POTEE A26C1A POTE2 VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
Q6S8J3 Y940 Sugiyama POTEE A26C1A POTE2 ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q6UX04 S203 Sugiyama CWC27 SDCCAG10 UNQ438/PRO871 KKEKPEEEVKKLKPKGTKNFsLLsFGEEAEEEEEEVNRVSQ
Q6UX04 S206 Sugiyama CWC27 SDCCAG10 UNQ438/PRO871 KPEEEVKKLKPKGTKNFsLLsFGEEAEEEEEEVNRVSQSMK
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q71UM5 S78 Sugiyama RPS27L GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q7L2E3 S226 Sugiyama DHX30 DDX30 KIAA0890 DFLSMTQQDSHAPLRDSRGssFEMTDDDSAIRALTQFPLPK
Q7RTS7 S153 Sugiyama KRT74 K6IRS4 KB37 KRT5C KRT6IRS4 IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z417 S652 Sugiyama NUFIP2 KIAA1321 PIG1 NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z417 S655 Sugiyama NUFIP2 KIAA1321 PIG1 LGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsIWNL
Q7Z4V5 S370 Sugiyama HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 KERRRERADRGEAERGsGGssGDELREDDEPVKKRGRKGRG
Q7Z4V5 S395 Sugiyama HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 REDDEPVKKRGRKGRGRGPPsssDsEPEAELEREAKKSAKK
Q7Z4V5 S399 Sugiyama HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 EPVKKRGRKGRGRGPPsssDsEPEAELEREAKKSAKKPQSS
Q7Z794 S177 Sugiyama KRT77 KRT1B IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q7Z7L8 S425 Sugiyama C11orf96 AG2 RstQsLSLQREQLSSCKLRNsLDssDsDsAL__________
Q86UF2 S138 Sugiyama CTAGE6 CTAGE6P EKAAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKS
Q86V81 S145 Sugiyama ALYREF ALY BEF THOC4 LFAEFGtLKKAAVHYDRsGRsLGtADVHFERKADALKAMKQ
Q86V81 S239 Sugiyama ALYREF ALY BEF THOC4 tRGGARGRGRGAGRNSKQQLsAEELDAQLDAyNARMDts__
Q86V81 S8 Sugiyama ALYREF ALY BEF THOC4 _____________MADKMDMsLDDIIKLNRSQRGGRGGGRG
Q86W56 S286 Sugiyama PARG VGSEDVGTGPKNDNKLTRQEsCLGNsPPFEKESEPEsPMDV
Q86Y46 S145 Sugiyama KRT73 K6IRS3 KB36 KRT6IRS3 IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8IWX8 S904 Sugiyama CHERP DAN26 SCAF6 KGVGVALDDPyENyRRNKsysFIARMKARDECK________
Q8IX94 S138 Sugiyama CTAGE4 EKAAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKS
Q8N3V7 S263 Sugiyama SYNPO KIAA1029 HsMEGYSEEASLLRHLEKVAsEEEEVPLVVYLKENAALLTA
Q8N6H7 S368 Sugiyama ARFGAP2 ZNF289 Nbla10535 VGTFASGPPKYKDNPFsLGEsFGsRWDTDAAWGMDRVEEKE
Q8N6H7 S432 Sugiyama ARFGAP2 ZNF289 Nbla10535 RssGLEssEARQKFAGAKAIssDMFFGREVDAEyEARSRLQ
Q8N8S7 S125 Sugiyama ENAH MENA MHALEVLNSQETGPTLPRQNsQLPAQVQNGPSQEELEIQRR
Q8NBS9 S426 Sugiyama TXNDC5 TLP46 UNQ364/PRO700 KKVSEHSGGRDLDSLHRFVLsQAKDEL______________
Q8ND56 S368 Sugiyama LSM14A C19orf13 FAM61A RAP55 RAP55A EGNADEEDPLGPNCYYDKTKsFFDNIsCDDNRERRPtWAEE
Q8ND56 S374 Sugiyama LSM14A C19orf13 FAM61A RAP55 RAP55A EDPLGPNCYYDKTKsFFDNIsCDDNRERRPtWAEERRLNAE
Q8NE71 S109 Sugiyama ABCF1 ABC50 DDDGEEKELMERLKKLsVPtsDEEDEVPAPKPRGGKKTKGG
Q8NE71 S140 Sugiyama ABCF1 ABC50 PRGGKKTKGGNVFAALIQDQsEEEEEEEKHPPKPAKPEKNR
Q8NE71 S166 Sugiyama ABCF1 ABC50 EEKHPPKPAKPEKNRINKAVsEEQQPALKGKKGKEEKSKGK
Q8NE71 T108 Sugiyama ABCF1 ABC50 VDDDGEEKELMERLKKLsVPtsDEEDEVPAPKPRGGKKTKG
Q8NEF9 S274 Sugiyama SRFBP1 CEEEKEYFDDstEERFYKQSsMSEDsDsGDDFFIGKVRRTR
Q8NEY1 S377 Sugiyama NAV1 KIAA1151 KIAA1213 POMFIL3 STEERIN1 TMPMRsPSKLSHISRLELVEsLDSDEVDLKsGyMsDSDLMG
Q8NEY1 S808 Sugiyama NAV1 KIAA1151 KIAA1213 POMFIL3 STEERIN1 TAKSFVKPPsLANLDKVNsNsLDLPSSSDTTHASKVPDLHA
Q8NFD5 S1744 Sugiyama ARID1B BAF250B DAN15 KIAA1235 OSA2 ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q8NFH8 S631 Sugiyama REPS2 POB1 AIQTAIRKNKEANAVLARLNsELQQQLKEVHQERIALENQL
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8TEQ6 S757 Sugiyama GEMIN5 PKAKPKKKKKPTLRtPVKLEsIDGNEEEsMKENsGPVENGV
Q8TEU7 S1117 Sugiyama RAPGEF6 PDZGEF2 NAKKLYEDAQMARKVKQYLssLDVETDEEKFQMMSLQWEPA
Q8WVC0 T477 Sugiyama LEO1 RDL FDVYKAPLQGDHNHLFIRQGtGLQGQAVFKTKLTFRPHstD
Q8WWI1 S1510 Sugiyama LMO7 FBX20 FBXO20 KIAA0858 RsAsVNKEPVSLPGIMRRGEsLDNLDsPRSNSWRQPPWLNQ
Q8WWI1 S706 Sugiyama LMO7 FBX20 FBXO20 KIAA0858 RLMVERLFQKIYGENGsKsMsDVsAEDVQNLRQLRYEEMQK
Q8WWI1 S805 Sugiyama LMO7 FBX20 FBXO20 KIAA0858 LQDRESQNQKSTVPSRRRMysFDDVLEEGKRPPtMtVSEAS
Q8WWI1 T932 Sugiyama LMO7 FBX20 FBXO20 KIAA0858 VtPRPFGsQtRGISsLPRsYtMDDAWKYNGDVEDIKRtPNN
Q8WX93 S479 Sugiyama PALLD KIAA0992 CGI-151 VLECRVRGAPPLQVQWFRQGsEIQDsPDFRILQKKPRSTAE
Q8WXH0 S2781 Sugiyama SYNE2 KIAA1011 NUA ILSQIRKCKVTHDGILARQQsVEsLAEEVKDKVPSLTTYEG
Q92625 S663 Sugiyama ANKS1A ANKS1 KIAA0229 ODIN sRsEsLsNCsIGKKRLEKsPsFAsEWDEIEKIMssIGEGID
Q92688 S117 Sugiyama ANP32B APRIL PHAPI2 GNKLKDIstLEPLKKLECLKsLDLFNCEVtNLNDyREsVFK
Q92733 T261 Sugiyama PRCC TPRC sPsAIKAAAKSAALQVTKQItQEEDDsDEEVAPENFFsLPE
Q92804 S289 Sugiyama TAF15 RBP56 TAF2N PMINLYTDKDTGKPKGEAtVsFDDPPsAKAAIDWFDGKEFH
Q96CT7 S141 Sugiyama CCDC124 KsHLEVPLEENVNRRVLEEGsVEARTIEDAIAVLsVAEEAA
Q96D71 S767 Sugiyama REPS1 AIQAsIRRNKETNTVLARLNsELQQQLKDVLEERISLEVQL
Q96MH2 S194 Sugiyama HEXIM2 L3 EAGDSDGRGRAHGEFQRKDFsEtYERFHTESLQGRSKQELV
Q96MH2 S51 Sugiyama HEXIM2 L3 QtPPERHDsGGsLPLtPRMEsHsEDEDLAGAVGGLGWNsRs
Q96MH2 T196 Sugiyama HEXIM2 L3 GDSDGRGRAHGEFQRKDFsEtYERFHTESLQGRSKQELVRD
Q96SB4 S51 Sugiyama SRPK1 RGsAPHSESDLPEQEEEILGsDDDEQEDPNDYCKGGYHLVK
Q96ST3 S158 Sugiyama SIN3A GSQPQVYNDFLDIMKEFKSQsIDtPGVISRVSQLFKGHPDL
Q96T58 S1268 Sugiyama SPEN KIAA0929 MINT SHARP SRQISEDsERtGGsPsVRHGsFHEDEDPIGsPRLLSVKGsP
Q99613 S39 Sugiyama EIF3C EIF3S8 GEELVTKPVGGNyGKQPLLLsEDEEDTKRVVRSAKDKRFEE
Q99613 S865 Sugiyama EIF3C EIF3S8 HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF
Q99618 S94 Sugiyama CDCA3 C8 GRCC8 TOME1 ARtPMKTSsGDPPsPLVKQLsEVFETEDSKSNLPPEPVLPP
Q99755 S486 Sugiyama PIP5K1A GssFSRRAGssGNsCItyQPsVsGEHKAQVTTKAEVEPGVH
Q9BQE3 S439 Sugiyama TUBA1C TUBA6 SEAREDMAALEKDyEEVGADsADGEDEGEEy__________
Q9BTE6 S174 Sugiyama AARSD1 IEQSVNEKIRDRLPVNVRELsLDDPEVEQVsGRGLPDDHAG
Q9BVJ6 S437 Sugiyama UTP14A SDCCAG16 EEILLREFEERRSLRKRsELsQDAEPAGsQEtKDsGsQEVL
Q9BVJ6 S77 Sugiyama UTP14A SDCCAG16 NRRKLAERSEASLKVSEFNVssEGsGEKLVLADLLEPVKTS
Q9BXS6 S198 Sugiyama NUSAP1 ANKT BM-037 PRO0310 TAITtPNFKKLHEAHFKEMEsIDQYIERKKKHFEEHNSMNE
Q9BY44 S526 Sugiyama EIF2A CDA02 MSTP004 MSTP089 sPDLAPtPAPQstPRNtVsQsIsGDPEIDKKIKNLKKKLKA
Q9BYB0 S782 GPS6 SHANK3 KIAA1650 PROSAP2 PSAP2 GLPGPEKLPGSLRKGIPRtKsVGEDEKLASLLEGRFPRSTs
Q9BYX7 S239 Sugiyama POTEKP ACTBL3 FKSG30 VALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPE
Q9BYX7 Y240 Sugiyama POTEKP ACTBL3 FKSG30 ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9BZI7 T153 Sugiyama UPF3B RENT3B UPF3X FAPFQKAAKKKTKKRDTKVGtIDDDPEyRKFLEsyAtDNEK
Q9C0C2 S1616 Sugiyama TNKS1BP1 KIAA1741 TAB182 LSEAADsDAHLFQDSTEPRAsRVPssDEEVVEEPQsRRTRM
Q9C0C2 S1620 Sugiyama TNKS1BP1 KIAA1741 TAB182 ADsDAHLFQDSTEPRAsRVPssDEEVVEEPQsRRTRMsLGT
Q9C0C2 S221 Sugiyama TNKS1BP1 KIAA1741 TAB182 TyGtTTAPRDEDGstLFRGWsQEGPVKsPAECREEHsKtPE
Q9C0C2 S437 Sugiyama TNKS1BP1 KIAA1741 TAB182 HLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAALPQGQGsQ
Q9C0C2 S899 Sugiyama TNKS1BP1 KIAA1741 TAB182 RDVsLGDWEFGKRDsLGAyAsQDANEQGQDLGKRDHHGRys
Q9C0C2 S920 Sugiyama TNKS1BP1 KIAA1741 TAB182 QDANEQGQDLGKRDHHGRyssQDADEQDWEFQKRDVsLGTy
Q9H1E3 S113 Sugiyama NUCKS1 NUCKS JC7 RQAASKAASKQREMLMEDVGsEEEQEEEDEAPFQEKDsGsD
Q9H1K0 S548 Sugiyama RBSN ZFYVE20 RELEREREQFRVASLHTRTRsLDFREIGPFQLEPSREPRTH
Q9H6S3 S693 Sugiyama EPS8L2 EPS8R2 PP13181 EGVRVySQLTMQKAFLEKQQsGSELEELMNKFHSMNQRRGE
Q9H788 S315 Sugiyama SH2D4A PPP1R38 SH2A LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9H7E9 T216 Sugiyama C8orf33 ATRKKSQRVCRPRSIWRAKAtLDMPDEEFRFNFF_______
Q9H814 S226 Sugiyama PHAX RNUXA RLGNRPEMNYKGRYEITAEDsQEKVADEISFRLQEPKKDLI
Q9H814 S298 Sugiyama PHAX RNUXA NGSRRRTPGGVFLNLLKNtPsISEEQIKDIFyIENQKEYEN
Q9NP61 S367 Sugiyama ARFGAP3 ARFGAP1 DsyFTSSSSYFDEPVELRsssFssWDDssDSyWKKETSKDT
Q9NP61 S455 Sugiyama ARFGAP3 ARFGAP1 RQsQADYETRARLERLsAsssIssADLFEEPRKQPAGNysL
Q9NRA8 S977 Sugiyama EIF4ENIF1 KWFGSDVLQQPLPSMPAKVIsVDELEYRQ____________
Q9NSB2 S178 Sugiyama KRT84 KRTHB4 AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9NUU7 T467 Sugiyama DDX19A DDX19L SMNILNRIQEHFNKKIERLDtDDLDEIEKIAN_________
Q9NYF8 S198 Sugiyama BCLAF1 BTF KIAA0164 PLKsKsQEEPKDtFEHDPsEsIDEFNKssAtsGDIWPGLsA
Q9NZB2 T413 Sugiyama FAM120A C9orf10 KIAA0183 OSSA yPysLSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyER
Q9P013 T46 Sugiyama CWC15 C11orf5 AD-002 HSPC148 LSKQYSSRDLPSHTKIKYRQttQDAPEEVRNRDFRRELEER
Q9P031 T86 Sugiyama CCDC59 BR22 TAP26 HSPC128 SYKKLLRKEKKAQTSLESQFtDRYPDNLKHLyLAEEERHRK
Q9UBR2 S78 Sugiyama CTSZ SPADLPKSWDWRNVDGVNyAsItRNQHIPQYCGSCWAHAST
Q9UGY1 S21 Sugiyama NOL12 MGRNKKKKRDGDDRRPRLVLsFDEEKRREyLTGFHKRKVER
Q9UHA3 S68 Sugiyama RSL24D1 C15orf15 RPL24L My024 KVRWTKAFRKAAGKELtVDNsFEFEKRRNEPIKYQRELWNK
Q9UHA3 T64 Sugiyama RSL24D1 C15orf15 RPL24L My024 RNPRKVRWTKAFRKAAGKELtVDNsFEFEKRRNEPIKYQRE
Q9UHB6 S617 Sugiyama LIMA1 EPLIN SREBP3 PP624 FQstsVKsPKtVsPPIRKGWsMsEQSEESVGGRVAERKQVE
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UII2 S63 Sugiyama ATP5IF1 ATPI ATPIF1 AGGAFGKREQAEEERyFRAQsREQLAALKKHHEEEIVHHKK
Q9UJU6 S269 Sugiyama DBNL CMAP SH3P7 PP5423 NEQESAVHPREIFKQKERAMsttsIssPQPGKLRsPFLQKQ
Q9UKV3 S661 Sugiyama ACIN1 ACINUS KIAA0670 SRSRSRSASSNSRKsLsPGVsRDsstsytEtKDPssGQEVA
Q9ULD2 S1203 Sugiyama MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1 QENEELKARMDKHMAISRQLstEQAVLQESLEKESKVNKRL
Q9ULD2 T1204 Sugiyama MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1 ENEELKARMDKHMAISRQLstEQAVLQESLEKESKVNKRLs
Q9UMR2 T468 Sugiyama DDX19B DBP5 DDX19 TDBP SMNILNRIQEHFNKKIERLDtDDLDEIEKIAN_________
Q9UMX5 T48 Sugiyama NENF CIR2 SPUF TARAGQTPRPAERGPPVRLFtEEELARYGGEEEDQPIyLAV
Q9UNH7 S316 Sugiyama SNX6 LKYYLRESQAAKDLLYRRsRsLVDYENANKALDKARAKNKD
Q9UNX3 T8 Sugiyama RPL26L1 RPL26P1 _____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Q9UNZ2 S192 Sugiyama NSFL1C UBXN2C KRQHssQDVHVVLKLWKsGFsLDNGELRSyQDPsNAQFLEs
Q9UPQ0 S201 Sugiyama LIMCH1 KIAA1102 DCWDsERsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVV
Q9UQ35 S854 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sHSsssPHPKVKsGtPPRQGsItsPQANEQsVtPQRRsCFE
Q9UQD0 S561 SIGNOR SCN8A MED sIMNQSLLSIPGSPFLSRHNsKSSIFSFRGPGRFRDPGSEN
Q9UQD0 S641 SIGNOR SCN8A MED SQGSRSSRIFPSLRRSVKRNstVDCNGVVSLIGGPGSHIGG
Q9UQD0 T642 SIGNOR SCN8A MED QGSRSSRIFPSLRRSVKRNstVDCNGVVSLIGGPGSHIGGR
Q9UQL6 S259 SIGNOR HDAC5 KIAA0600 KLPLPGPYDSRDDFPLRKTAsEPNLKVRSRLKQKVAERRss
Q9UQL6 S498 SIGNOR HDAC5 KIAA0600 ATSMRTVGKLPRHRPLSRtQssPLPQSPQALQQLVMQQQHQ
Q9UQM7 S25 Sugiyama CAMK2A CAMKA KIAA0968 TCTRFTEEYQLFEELGKGAFsVVRRCVKVLAGQEYAAKIIN
Q9Y237 S72 Sugiyama PIN4 MEAMEKLKSGMRFNEVAAQysEDKARQGGDLGWMTRGSMVG
Q9Y2B0 S115 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 QIDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKF
Q9Y2B0 S63 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 AQVDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLE
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2H0 S977 Sugiyama DLGAP4 DAP4 KIAA0964 SAPAP4 RKRLLAAKRAAsVRQNsAtEsADsIEIYVPEAQTRL_____
Q9Y2H0 S980 Sugiyama DLGAP4 DAP4 KIAA0964 SAPAP4 LLAAKRAAsVRQNsAtEsADsIEIYVPEAQTRL________
Q9Y2T7 S137 Sugiyama YBX2 CSDA3 MSY2 EDVFVHQtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEA
Q9Y2T7 T115 Sugiyama YBX2 CSDA3 MSY2 LGTVKWFNVRNGyGFINRNDtKEDVFVHQtAIKRNNPRKFL
Q9Y2T7 T143 Sugiyama YBX2 CSDA3 MSY2 QtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEATNVTGP
Q9Y2X7 S592 Sugiyama GIT1 PLLsCsQEGsRHtsKLsRHGsGADsDyENtQSGDPLLGLEG
Q9Y3F4 S153 Sugiyama STRAP MAWD UNRIP EAEPKEISGHTSGIKKALWCsEDKQILsADDKtVRLWDHAT
Q9Y4L1 S742 Sugiyama HYOU1 GRP170 HSPH4 ORP150 KLQDLTLRDLEKQEREKAANsLEAFIFEtQDKLyQPEyQEV
Q9Y4L1 T750 Sugiyama HYOU1 GRP170 HSPH4 ORP150 DLEKQEREKAANsLEAFIFEtQDKLyQPEyQEVsTEEQREE
Q9Y4W2 S641 Sugiyama LAS1L MSTP060 ENARLLAQKRGALQGsAWQVssEDVRWDTFPLGRMPGQTED
Q9Y5L4 S57 Sugiyama TIMM13 TIM13B TIMM13A TIMM13B ELLQRMTDKCFRKCIGKPGGsLDNSEQKCIAMCMDRyMDAW
Q9Y5S9 S56 Sugiyama RBM8A RBM8 HSPC114 MDS014 KGRGFGsEEGsRARMREDyDsVEQDGDEPGPQRSVEGWILF
Q9Y608 S18 Sugiyama LRRFIP2 ___MGTPASGRKRTPVKDRFsAEDEALsNIAREAEARLAAK
Q9Y618 S2407 SIGNOR NCOR2 CTG26 SDHTLTSPGGGGKAKVSGRPsSRKAKsPAPGLASGDRPPsV
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Chromatin organization R-HSA-4839726 1.999099e-10 9.699 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.085976e-09 8.964 0 0
Chromatin modifying enzymes R-HSA-3247509 1.272207e-09 8.895 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 3.524752e-09 8.453 0 0
Cell Cycle R-HSA-1640170 4.973370e-09 8.303 0 0
M Phase R-HSA-68886 3.167308e-08 7.499 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 7.669090e-08 7.115 0 0
Cell Cycle, Mitotic R-HSA-69278 1.036079e-07 6.985 0 0
Apoptotic execution phase R-HSA-75153 1.495903e-07 6.825 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.156221e-06 5.937 0 0
mRNA Splicing R-HSA-72172 2.346201e-06 5.630 0 0
DNA Double-Strand Break Repair R-HSA-5693532 3.453411e-06 5.462 0 0
HDACs deacetylate histones R-HSA-3214815 6.773629e-06 5.169 0 0
Mitotic Prophase R-HSA-68875 8.873107e-06 5.052 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 8.580205e-06 5.067 0 0
HATs acetylate histones R-HSA-3214847 1.289036e-05 4.890 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.398107e-05 4.854 0 0
Cell-Cell communication R-HSA-1500931 1.467303e-05 4.833 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.761154e-05 4.754 0 0
Cell Cycle Checkpoints R-HSA-69620 1.997408e-05 4.700 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.207220e-05 4.656 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.207220e-05 4.656 0 0
Metabolism of RNA R-HSA-8953854 2.276461e-05 4.643 0 0
Signaling by Hippo R-HSA-2028269 2.704859e-05 4.568 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.923120e-05 4.534 0 0
Mitotic Prometaphase R-HSA-68877 3.654346e-05 4.437 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.834662e-05 4.416 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 4.337371e-05 4.363 0 0
Epigenetic regulation of gene expression R-HSA-212165 4.829335e-05 4.316 0 0
Nucleosome assembly R-HSA-774815 5.201015e-05 4.284 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.201015e-05 4.284 0 0
Deubiquitination R-HSA-5688426 4.977222e-05 4.303 0 0
Cellular Senescence R-HSA-2559583 6.199673e-05 4.208 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 7.578291e-05 4.120 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 7.748579e-05 4.111 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 8.491644e-05 4.071 0 0
DNA Double Strand Break Response R-HSA-5693606 9.407852e-05 4.027 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.169525e-04 3.932 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 1.271708e-04 3.896 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.339694e-04 3.873 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.555436e-04 3.808 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.530030e-04 3.815 0 0
Homology Directed Repair R-HSA-5693538 1.640327e-04 3.785 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.820666e-04 3.740 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.340900e-04 3.631 0 0
Cell junction organization R-HSA-446728 2.268983e-04 3.644 0 0
Post NMDA receptor activation events R-HSA-438064 2.381793e-04 3.623 1 0
Estrogen-dependent gene expression R-HSA-9018519 2.659597e-04 3.575 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 3.171211e-04 3.499 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.309944e-04 3.480 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 3.427218e-04 3.465 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.613171e-04 3.442 0 0
Nephrin family interactions R-HSA-373753 3.599640e-04 3.444 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 3.848262e-04 3.415 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 3.848262e-04 3.415 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 4.935445e-04 3.307 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 6.113912e-04 3.214 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 6.113912e-04 3.214 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 6.212535e-04 3.207 0 0
Nuclear Envelope Breakdown R-HSA-2980766 6.430901e-04 3.192 0 0
Recycling pathway of L1 R-HSA-437239 6.641864e-04 3.178 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 7.207841e-04 3.142 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 7.932403e-04 3.101 0 0
Meiotic synapsis R-HSA-1221632 7.916484e-04 3.101 0 0
DNA Repair R-HSA-73894 8.134918e-04 3.090 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 7.932403e-04 3.101 0 0
Gene expression (Transcription) R-HSA-74160 8.302020e-04 3.081 1 0
Protein ubiquitination R-HSA-8852135 9.019542e-04 3.045 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 9.794605e-04 3.009 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 9.948017e-04 3.002 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.061233e-03 2.974 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.121744e-03 2.950 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.182111e-03 2.927 0 0
Gene Silencing by RNA R-HSA-211000 1.197880e-03 2.922 0 0
Ub-specific processing proteases R-HSA-5689880 1.270371e-03 2.896 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.327451e-03 2.877 0 0
Meiotic recombination R-HSA-912446 1.397269e-03 2.855 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.339151e-03 2.873 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.400350e-03 2.854 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.418413e-03 2.848 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.418413e-03 2.848 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.455562e-03 2.837 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.661836e-03 2.779 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.661836e-03 2.779 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.661836e-03 2.779 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.661836e-03 2.779 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.661836e-03 2.779 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.661836e-03 2.779 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.661836e-03 2.779 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.661836e-03 2.779 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.661836e-03 2.779 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.661836e-03 2.779 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.661836e-03 2.779 0 0
Separation of Sister Chromatids R-HSA-2467813 1.590929e-03 2.798 0 0
Meiosis R-HSA-1500620 1.694561e-03 2.771 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.661954e-03 2.779 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.769420e-03 2.752 1 0
Cell-cell junction organization R-HSA-421270 1.576733e-03 2.802 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.859665e-03 2.731 0 0
Death Receptor Signaling R-HSA-73887 1.993035e-03 2.700 0 0
Mitotic Anaphase R-HSA-68882 2.116370e-03 2.674 0 0
G2/M Checkpoints R-HSA-69481 2.130317e-03 2.672 0 0
Nervous system development R-HSA-9675108 2.180124e-03 2.662 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.363873e-03 2.626 1 1
Mitotic Metaphase and Anaphase R-HSA-2555396 2.288710e-03 2.640 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.354143e-03 2.628 1 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.354143e-03 2.628 0 0
Adherens junctions interactions R-HSA-418990 2.473113e-03 2.607 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.529340e-03 2.597 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.556057e-03 2.592 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.773249e-03 2.557 0 0
Axon guidance R-HSA-422475 2.792472e-03 2.554 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.832775e-03 2.548 0 0
Packaging Of Telomere Ends R-HSA-171306 3.182258e-03 2.497 0 0
PKMTs methylate histone lysines R-HSA-3214841 3.167384e-03 2.499 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 3.182258e-03 2.497 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 3.288256e-03 2.483 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.424219e-03 2.465 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 3.449555e-03 2.462 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.520181e-03 2.453 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 3.605081e-03 2.443 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.609750e-03 2.443 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.624846e-03 2.441 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.648267e-03 2.438 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 3.683868e-03 2.434 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.979217e-03 2.400 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.999510e-03 2.398 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.999510e-03 2.398 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.785218e-03 2.422 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 4.476287e-03 2.349 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 4.476287e-03 2.349 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 4.476287e-03 2.349 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 4.476287e-03 2.349 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 4.637729e-03 2.334 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 4.742617e-03 2.324 0 0
DNA methylation R-HSA-5334118 4.891754e-03 2.311 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 4.891754e-03 2.311 0 0
Defective pyroptosis R-HSA-9710421 5.313593e-03 2.275 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 5.399826e-03 2.268 0 0
Kinesins R-HSA-983189 5.701668e-03 2.244 0 0
Regulation of TP53 Activity R-HSA-5633007 5.859199e-03 2.232 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 6.649689e-03 2.177 0 0
NRAGE signals death through JNK R-HSA-193648 7.163185e-03 2.145 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 7.304045e-03 2.136 0 0
L1CAM interactions R-HSA-373760 7.371221e-03 2.132 0 0
HIV Life Cycle R-HSA-162587 7.727637e-03 2.112 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 7.757418e-03 2.110 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 7.836000e-03 2.106 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.912850e-03 2.102 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 7.921026e-03 2.101 1 0
Membrane Trafficking R-HSA-199991 8.207993e-03 2.086 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 8.503671e-03 2.070 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 8.503671e-03 2.070 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 8.667866e-03 2.062 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 8.735042e-03 2.059 0 0
mRNA 3'-end processing R-HSA-72187 9.011481e-03 2.045 0 0
ESR-mediated signaling R-HSA-8939211 9.350964e-03 2.029 0 0
Signal Transduction R-HSA-162582 9.139315e-03 2.039 1 0
Vpr-mediated nuclear import of PICs R-HSA-180910 9.842047e-03 2.007 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.842047e-03 2.007 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 9.897182e-03 2.004 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.015141e-02 1.993 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.021223e-02 1.991 0 0
Signaling by VEGF R-HSA-194138 1.028562e-02 1.988 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.043433e-02 1.982 1 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.043433e-02 1.982 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.089455e-02 1.963 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.112322e-02 1.954 0 0
Apoptosis R-HSA-109581 1.135172e-02 1.945 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.168285e-02 1.932 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.229344e-02 1.910 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.231152e-02 1.910 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.231354e-02 1.910 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.237627e-02 1.907 0 0
RNA Polymerase I Transcription R-HSA-73864 1.237720e-02 1.907 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.386207e-02 1.858 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.364495e-02 1.865 1 0
Nuclear import of Rev protein R-HSA-180746 1.458134e-02 1.836 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.386207e-02 1.858 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.458134e-02 1.836 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.558280e-02 1.807 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.568664e-02 1.804 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.568664e-02 1.804 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.596266e-02 1.797 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 1.640603e-02 1.785 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.674120e-02 1.776 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.706995e-02 1.768 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.757241e-02 1.755 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.812097e-02 1.742 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.812097e-02 1.742 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.812097e-02 1.742 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.020160e-02 1.695 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.842275e-02 1.735 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.842275e-02 1.735 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.083672e-02 1.681 1 1
RNA Polymerase I Promoter Escape R-HSA-73772 1.925154e-02 1.716 0 0
HCMV Early Events R-HSA-9609690 1.996136e-02 1.700 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.973179e-02 1.705 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.065499e-02 1.685 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.965180e-02 1.707 0 0
Chromosome Maintenance R-HSA-73886 1.971788e-02 1.705 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.879775e-02 1.726 0 0
Diseases of programmed cell death R-HSA-9645723 2.026256e-02 1.693 0 0
RET signaling R-HSA-8853659 1.986230e-02 1.702 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.083672e-02 1.681 1 1
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.092114e-02 1.679 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.092114e-02 1.679 0 0
Metabolism of non-coding RNA R-HSA-194441 2.183957e-02 1.661 0 0
snRNP Assembly R-HSA-191859 2.183957e-02 1.661 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.332523e-02 1.632 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.332523e-02 1.632 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.521491e-02 1.598 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.521491e-02 1.598 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.638780e-02 1.579 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.577590e-02 1.589 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.577590e-02 1.589 0 0
Regulation of CDH11 function R-HSA-9762292 2.376661e-02 1.624 0 0
PI3K/AKT activation R-HSA-198203 2.376661e-02 1.624 0 0
MTOR signalling R-HSA-165159 2.383834e-02 1.623 0 0
CREB phosphorylation R-HSA-199920 2.640346e-02 1.578 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.604030e-02 1.584 0 0
Signaling by ALK in cancer R-HSA-9700206 2.604030e-02 1.584 0 0
G2/M Transition R-HSA-69275 2.492086e-02 1.603 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.343629e-02 1.630 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.643659e-02 1.578 0 0
Cleavage of the damaged purine R-HSA-110331 2.297813e-02 1.639 0 0
Depurination R-HSA-73927 2.643659e-02 1.578 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.727558e-02 1.564 0 0
HIV elongation arrest and recovery R-HSA-167287 2.747091e-02 1.561 0 0
Pausing and recovery of HIV elongation R-HSA-167290 2.747091e-02 1.561 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.812902e-02 1.551 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.921266e-02 1.534 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.921266e-02 1.534 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.013513e-02 1.521 0 0
DNA Replication Pre-Initiation R-HSA-69002 3.053741e-02 1.515 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.121639e-02 1.506 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 3.134800e-02 1.504 0 0
Centrosome maturation R-HSA-380287 3.204911e-02 1.494 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.210927e-02 1.493 0 0
DCC mediated attractive signaling R-HSA-418885 3.220788e-02 1.492 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 3.220788e-02 1.492 0 0
Regulation of CDH1 Function R-HSA-9764561 3.425128e-02 1.465 0 0
Aggrephagy R-HSA-9646399 3.445366e-02 1.463 0 0
RNA Polymerase II Transcription R-HSA-73857 3.554751e-02 1.449 1 0
Signaling by NTRK1 (TRKA) R-HSA-187037 3.575335e-02 1.447 0 0
Programmed Cell Death R-HSA-5357801 3.577503e-02 1.446 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.625530e-02 1.441 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 3.910689e-02 1.408 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 3.910689e-02 1.408 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.662423e-02 1.436 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.662423e-02 1.436 0 0
Regulation of PTEN localization R-HSA-8948747 3.662423e-02 1.436 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.662423e-02 1.436 0 0
Disinhibition of SNARE formation R-HSA-114516 3.662423e-02 1.436 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 3.998169e-02 1.398 0 0
Signaling by RAS mutants R-HSA-6802949 3.905567e-02 1.408 1 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 3.905567e-02 1.408 1 1
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 3.905567e-02 1.408 1 1
Signaling downstream of RAS mutants R-HSA-9649948 3.905567e-02 1.408 1 1
Nucleotide Excision Repair R-HSA-5696398 3.722467e-02 1.429 0 0
Prolonged ERK activation events R-HSA-169893 3.964671e-02 1.402 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 4.059447e-02 1.392 0 0
Integration of provirus R-HSA-162592 3.998169e-02 1.398 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 3.998169e-02 1.398 0 0
Trafficking of AMPA receptors R-HSA-399719 4.295653e-02 1.367 1 1
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 4.295653e-02 1.367 0 0
Intracellular signaling by second messengers R-HSA-9006925 3.996892e-02 1.398 1 0
Interleukin-7 signaling R-HSA-1266695 4.104250e-02 1.387 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 3.904573e-02 1.408 0 0
Calmodulin induced events R-HSA-111933 4.385752e-02 1.358 1 0
Cellular responses to stress R-HSA-2262752 4.021987e-02 1.396 1 0
CaM pathway R-HSA-111997 4.385752e-02 1.358 1 0
Uptake and function of diphtheria toxin R-HSA-5336415 3.662423e-02 1.436 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 4.478544e-02 1.349 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 4.478544e-02 1.349 0 0
Early Phase of HIV Life Cycle R-HSA-162594 4.478544e-02 1.349 0 0
Late Phase of HIV Life Cycle R-HSA-162599 4.494746e-02 1.347 0 0
Cellular responses to stimuli R-HSA-8953897 4.552521e-02 1.342 1 0
Regulation of PTEN gene transcription R-HSA-8943724 4.654284e-02 1.332 0 0
Cilium Assembly R-HSA-5617833 4.665812e-02 1.331 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.773037e-02 1.321 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 4.809223e-02 1.318 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 4.809223e-02 1.318 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 4.882356e-02 1.311 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 4.882356e-02 1.311 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 4.882356e-02 1.311 0 0
Ca-dependent events R-HSA-111996 4.947086e-02 1.306 1 0
Cleavage of the damaged pyrimidine R-HSA-110329 4.947086e-02 1.306 0 0
Depyrimidination R-HSA-73928 4.947086e-02 1.306 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 5.010031e-02 1.300 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 5.010031e-02 1.300 0 0
Cellular response to heat stress R-HSA-3371556 5.179241e-02 1.286 1 0
Signaling by PDGFR in disease R-HSA-9671555 5.270531e-02 1.278 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 5.270531e-02 1.278 1 1
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 5.270531e-02 1.278 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 5.308947e-02 1.275 0 0
HIV Infection R-HSA-162906 5.374949e-02 1.270 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 5.421224e-02 1.266 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 5.472017e-02 1.262 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.509000e-02 1.259 0 0
Nuclear RNA decay R-HSA-9930044 5.602505e-02 1.252 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 5.602505e-02 1.252 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 5.602505e-02 1.252 1 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 5.602505e-02 1.252 0 0
Activation of HOX genes during differentiation R-HSA-5619507 5.635733e-02 1.249 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 5.635733e-02 1.249 0 0
ISG15 antiviral mechanism R-HSA-1169408 5.676501e-02 1.246 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.684631e-02 1.245 0 0
IRS activation R-HSA-74713 5.684631e-02 1.245 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 5.756723e-02 1.240 0 0
Macroautophagy R-HSA-1632852 6.038627e-02 1.219 0 0
Selective autophagy R-HSA-9663891 6.076366e-02 1.216 0 0
mTORC1-mediated signalling R-HSA-166208 6.145081e-02 1.211 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 6.158821e-02 1.211 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 7.772616e-02 1.109 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 7.772616e-02 1.109 0 0
WNT mediated activation of DVL R-HSA-201688 6.299275e-02 1.201 0 0
ALK mutants bind TKIs R-HSA-9700645 6.299275e-02 1.201 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 7.187549e-02 1.143 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 6.342863e-02 1.198 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 7.142459e-02 1.146 0 0
Regulation of TNFR1 signaling R-HSA-5357905 7.559910e-02 1.121 0 0
Autophagy R-HSA-9612973 6.793917e-02 1.168 0 0
COPI-mediated anterograde transport R-HSA-6807878 7.696144e-02 1.114 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 7.713023e-02 1.113 0 0
Signaling by NTRKs R-HSA-166520 6.420599e-02 1.192 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 7.142459e-02 1.146 0 0
DAG and IP3 signaling R-HSA-1489509 6.838591e-02 1.165 1 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 6.421144e-02 1.192 0 0
Reproduction R-HSA-1474165 6.727485e-02 1.172 0 0
Transport of connexons to the plasma membrane R-HSA-190872 6.808275e-02 1.167 0 0
Signaling by ALK R-HSA-201556 6.282315e-02 1.202 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 6.282315e-02 1.202 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 7.801940e-02 1.108 0 0
2-LTR circle formation R-HSA-164843 7.907998e-02 1.102 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 7.907998e-02 1.102 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 7.907998e-02 1.102 1 1
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 7.963830e-02 1.099 0 0
STING mediated induction of host immune responses R-HSA-1834941 7.963830e-02 1.099 0 0
Signalling to ERKs R-HSA-187687 8.001826e-02 1.097 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 8.001826e-02 1.097 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 8.131478e-02 1.090 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 8.145026e-02 1.089 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 8.145026e-02 1.089 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 8.231533e-02 1.085 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 8.412819e-02 1.075 0 0
PKR-mediated signaling R-HSA-9833482 8.412819e-02 1.075 0 0
DNA Replication R-HSA-69306 8.420167e-02 1.075 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 8.638834e-02 1.064 0 0
Signaling by FGFR1 in disease R-HSA-5655302 8.640093e-02 1.063 0 0
EPH-Ephrin signaling R-HSA-2682334 8.695386e-02 1.061 0 0
Regulation of cortical dendrite branching R-HSA-8985801 8.809250e-02 1.055 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 8.809250e-02 1.055 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 8.863182e-02 1.052 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 8.863182e-02 1.052 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 8.863182e-02 1.052 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.921146e-02 1.050 0 0
Regulation of TP53 Degradation R-HSA-6804757 8.921146e-02 1.050 0 0
RNA Polymerase III Transcription R-HSA-74158 8.921146e-02 1.050 0 0
FLT3 signaling in disease R-HSA-9682385 8.921146e-02 1.050 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.145257e-02 1.039 0 0
Negative regulation of MET activity R-HSA-6807004 9.222219e-02 1.035 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 9.222219e-02 1.035 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 9.222219e-02 1.035 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 9.222219e-02 1.035 0 0
Sema4D in semaphorin signaling R-HSA-400685 9.270204e-02 1.033 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 9.270204e-02 1.033 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 9.343858e-02 1.029 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.535575e-02 1.021 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.159775e-01 0.936 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.159775e-01 0.936 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.159775e-01 0.936 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.159775e-01 0.936 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.159775e-01 0.936 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.159775e-01 0.936 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.159775e-01 0.936 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.159775e-01 0.936 0 0
TRKA activation by NGF R-HSA-187042 1.272924e-01 0.895 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.272924e-01 0.895 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.272924e-01 0.895 0 0
MET activates PTPN11 R-HSA-8865999 1.272924e-01 0.895 0 0
Signaling by LTK in cancer R-HSA-9842640 1.014377e-01 0.994 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 1.276252e-01 0.894 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.276252e-01 0.894 0 0
SOS-mediated signalling R-HSA-112412 1.276252e-01 0.894 0 0
Activation of RAC1 R-HSA-428540 1.166250e-01 0.933 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.041201e-01 0.982 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 1.041201e-01 0.982 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.041201e-01 0.982 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.208465e-01 0.918 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 1.058122e-01 0.975 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.058122e-01 0.975 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.203761e-01 0.919 1 1
Signaling by EGFR in Cancer R-HSA-1643713 1.047754e-01 0.980 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.137972e-01 0.944 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 9.900247e-02 1.004 0 0
Striated Muscle Contraction R-HSA-390522 1.259792e-01 0.900 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.203538e-01 0.920 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.036643e-01 0.984 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.251038e-01 0.903 0 0
G0 and Early G1 R-HSA-1538133 1.022834e-01 0.990 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.112818e-01 0.954 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 1.041201e-01 0.982 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 9.900247e-02 1.004 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.203538e-01 0.920 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.022834e-01 0.990 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.166250e-01 0.933 0 0
Semaphorin interactions R-HSA-373755 1.064604e-01 0.973 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.261073e-01 0.899 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.261073e-01 0.899 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.091208e-01 0.962 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.208465e-01 0.918 0 0
Signaling by WNT R-HSA-195721 1.210914e-01 0.917 0 0
Mitochondrial calcium ion transport R-HSA-8949215 1.203761e-01 0.919 0 0
Telomere Maintenance R-HSA-157579 1.268222e-01 0.897 0 0
G alpha (12/13) signalling events R-HSA-416482 1.179546e-01 0.928 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.003870e-01 0.998 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 1.272924e-01 0.895 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.272924e-01 0.895 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.203761e-01 0.919 1 1
Regulation of MECP2 expression and activity R-HSA-9022692 1.137972e-01 0.944 1 1
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.093861e-01 0.961 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.251343e-01 0.903 0 0
Ion transport by P-type ATPases R-HSA-936837 1.148584e-01 0.940 1 1
Netrin-1 signaling R-HSA-373752 1.146791e-01 0.941 0 0
Base Excision Repair R-HSA-73884 1.120428e-01 0.951 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.313798e-01 0.881 0 0
HIV Transcription Elongation R-HSA-167169 1.318936e-01 0.880 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 1.318936e-01 0.880 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.318936e-01 0.880 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 1.347473e-01 0.870 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 1.358730e-01 0.867 0 0
Notch-HLH transcription pathway R-HSA-350054 1.358730e-01 0.867 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.360899e-01 0.866 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.378228e-01 0.861 0 0
Repression of WNT target genes R-HSA-4641265 1.378228e-01 0.861 0 0
HCMV Infection R-HSA-9609646 1.393270e-01 0.856 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.413730e-01 0.850 0 0
Co-inhibition by PD-1 R-HSA-389948 1.436333e-01 0.843 0 0
FLT3 Signaling R-HSA-9607240 1.439905e-01 0.842 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.457121e-01 0.837 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.457121e-01 0.837 0 0
Regulation of gene expression in beta cells R-HSA-210745 1.457121e-01 0.837 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.498873e-01 0.824 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.513545e-01 0.820 0 0
PLC beta mediated events R-HSA-112043 1.513545e-01 0.820 1 0
Transcription of the HIV genome R-HSA-167172 1.521481e-01 0.818 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.522538e-01 0.817 0 0
PERK regulates gene expression R-HSA-381042 1.522678e-01 0.817 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.524222e-01 0.817 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.524222e-01 0.817 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.524222e-01 0.817 0 0
Type I hemidesmosome assembly R-HSA-446107 1.559102e-01 0.807 0 0
RSK activation R-HSA-444257 1.559102e-01 0.807 0 0
MET receptor recycling R-HSA-8875656 1.559102e-01 0.807 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.559102e-01 0.807 0 0
Co-stimulation by ICOS R-HSA-9927354 1.559102e-01 0.807 0 0
MAP2K and MAPK activation R-HSA-5674135 1.566263e-01 0.805 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 1.577131e-01 0.802 0 0
Ephrin signaling R-HSA-3928664 1.577131e-01 0.802 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.577131e-01 0.802 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 1.577131e-01 0.802 0 0
Formation of axial mesoderm R-HSA-9796292 1.604309e-01 0.795 0 0
Frs2-mediated activation R-HSA-170968 1.604309e-01 0.795 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.604309e-01 0.795 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 1.604309e-01 0.795 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 1.608298e-01 0.794 0 0
tRNA processing in the nucleus R-HSA-6784531 1.620756e-01 0.790 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.630651e-01 0.788 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.672555e-01 0.777 0 0
Platelet degranulation R-HSA-114608 1.674421e-01 0.776 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.694625e-01 0.771 0 0
TNFR1-mediated ceramide production R-HSA-5626978 1.696683e-01 0.770 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 1.696683e-01 0.770 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.696683e-01 0.770 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.696683e-01 0.770 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.696683e-01 0.770 0 0
NADE modulates death signalling R-HSA-205025 1.696683e-01 0.770 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.185102e-01 0.661 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.185102e-01 0.661 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.185102e-01 0.661 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.185102e-01 0.661 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.185102e-01 0.661 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.185102e-01 0.661 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.185102e-01 0.661 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.185102e-01 0.661 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.139570e-01 0.670 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.139570e-01 0.670 0 0
ARMS-mediated activation R-HSA-170984 1.859088e-01 0.731 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 2.591455e-01 0.586 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 2.591455e-01 0.586 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.591455e-01 0.586 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 2.172453e-01 0.663 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.172453e-01 0.663 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 1.842785e-01 0.735 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 2.091880e-01 0.679 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 2.091880e-01 0.679 0 0
Phosphorylation of the APC/C R-HSA-176412 2.349789e-01 0.629 0 0
Tight junction interactions R-HSA-420029 1.874372e-01 0.727 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.424722e-01 0.615 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 2.424722e-01 0.615 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.254141e-01 0.647 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 2.452726e-01 0.610 0 0
Formation of the Early Elongation Complex R-HSA-113418 2.452726e-01 0.610 0 0
RAF activation R-HSA-5673000 2.455801e-01 0.610 1 1
Dual incision in TC-NER R-HSA-6782135 1.974208e-01 0.705 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.254944e-01 0.647 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 2.304066e-01 0.638 0 0
Downstream signal transduction R-HSA-186763 1.766205e-01 0.753 0 0
Formation of definitive endoderm R-HSA-9823730 1.985278e-01 0.702 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.975456e-01 0.704 0 0
Josephin domain DUBs R-HSA-5689877 2.172453e-01 0.663 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 2.172453e-01 0.663 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 2.254141e-01 0.647 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.950121e-01 0.710 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.331097e-01 0.632 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.728659e-01 0.762 0 0
TNF signaling R-HSA-75893 1.728659e-01 0.762 0 0
Long-term potentiation R-HSA-9620244 1.874372e-01 0.727 1 1
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.444424e-01 0.612 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.591455e-01 0.586 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.444424e-01 0.612 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 2.139570e-01 0.670 0 0
Signal attenuation R-HSA-74749 2.172453e-01 0.663 0 0
ERK/MAPK targets R-HSA-198753 2.201626e-01 0.657 0 0
S Phase R-HSA-69242 2.435434e-01 0.613 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.589161e-01 0.587 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.751993e-01 0.756 0 0
HDMs demethylate histones R-HSA-3214842 1.874372e-01 0.727 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.100407e-01 0.678 0 0
Generic Transcription Pathway R-HSA-212436 2.559558e-01 0.592 1 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.185102e-01 0.661 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 1.859088e-01 0.731 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 2.591455e-01 0.586 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 2.591455e-01 0.586 0 0
Bicarbonate transporters R-HSA-425381 2.495616e-01 0.603 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 2.091880e-01 0.679 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.091880e-01 0.679 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 2.349789e-01 0.629 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 2.201626e-01 0.657 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 2.061112e-01 0.686 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.950121e-01 0.710 0 0
Host Interactions of HIV factors R-HSA-162909 1.943962e-01 0.711 0 0
Signaling by FGFR4 in disease R-HSA-5655291 1.842785e-01 0.735 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.100407e-01 0.678 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.304066e-01 0.638 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.859088e-01 0.731 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.859088e-01 0.731 0 0
Suppression of apoptosis R-HSA-9635465 2.495616e-01 0.603 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.337244e-01 0.631 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.591455e-01 0.586 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 2.275717e-01 0.643 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.152445e-01 0.667 0 0
G-protein mediated events R-HSA-112040 2.209863e-01 0.656 1 0
Potential therapeutics for SARS R-HSA-9679191 1.979285e-01 0.703 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.859088e-01 0.731 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 2.275717e-01 0.643 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.424722e-01 0.615 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 2.114966e-01 0.675 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 2.591455e-01 0.586 0 0
Diseases of DNA repair R-HSA-9675135 2.270721e-01 0.644 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 2.139570e-01 0.670 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 2.578276e-01 0.589 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.018575e-01 0.695 0 0
IRE1alpha activates chaperones R-HSA-381070 1.893106e-01 0.723 0 0
Amyloid fiber formation R-HSA-977225 2.155063e-01 0.667 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 2.614723e-01 0.583 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.640112e-01 0.578 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.642009e-01 0.578 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 2.647359e-01 0.577 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 2.653467e-01 0.576 0 0
Signaling by Erythropoietin R-HSA-9006335 2.656117e-01 0.576 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.678911e-01 0.572 0 0
PCP/CE pathway R-HSA-4086400 2.681576e-01 0.572 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 2.694575e-01 0.570 0 0
Signaling by EGFR R-HSA-177929 2.694575e-01 0.570 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.091561e-01 0.510 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.091561e-01 0.510 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.091561e-01 0.510 0 0
Defective SLC17A5 causes Salla disease (SD) and ISSD R-HSA-5619035 3.091561e-01 0.510 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.091561e-01 0.510 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 3.091561e-01 0.510 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.091561e-01 0.510 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.091561e-01 0.510 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 3.091561e-01 0.510 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.091561e-01 0.510 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.091561e-01 0.510 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.091561e-01 0.510 0 0
Signalling to ERK5 R-HSA-198765 3.892924e-01 0.410 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 3.892924e-01 0.410 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.892924e-01 0.410 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.892924e-01 0.410 0 0
Signaling by RAS GAP mutants R-HSA-9753510 3.892924e-01 0.410 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.892924e-01 0.410 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 3.892924e-01 0.410 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.892924e-01 0.410 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 3.044298e-01 0.517 0 0
Autointegration results in viral DNA circles R-HSA-177539 3.044298e-01 0.517 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.044298e-01 0.517 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.044298e-01 0.517 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.825232e-01 0.549 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.825232e-01 0.549 0 0
Activation of TRKA receptors R-HSA-187015 3.491802e-01 0.457 0 0
TRIF-mediated programmed cell death R-HSA-2562578 3.491802e-01 0.457 0 0
Recycling of eIF2:GDP R-HSA-72731 3.491802e-01 0.457 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.491802e-01 0.457 0 0
PLC-gamma1 signalling R-HSA-167021 4.601373e-01 0.337 0 0
MET interacts with TNS proteins R-HSA-8875513 4.601373e-01 0.337 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 4.601373e-01 0.337 0 0
Signalling to STAT3 R-HSA-198745 4.601373e-01 0.337 0 0
Invadopodia formation R-HSA-8941237 4.601373e-01 0.337 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.601373e-01 0.337 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.601373e-01 0.337 0 0
MET activates RAS signaling R-HSA-8851805 3.158236e-01 0.501 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 3.158236e-01 0.501 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 3.158236e-01 0.501 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 3.158236e-01 0.501 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 3.158236e-01 0.501 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 3.158236e-01 0.501 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.884933e-01 0.540 0 0
Formation of annular gap junctions R-HSA-196025 3.929116e-01 0.406 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.929116e-01 0.406 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 3.929116e-01 0.406 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.929116e-01 0.406 0 0
GAB1 signalosome R-HSA-180292 3.158738e-01 0.500 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 3.158738e-01 0.500 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 3.158738e-01 0.500 0 0
Activation of the pre-replicative complex R-HSA-68962 2.863557e-01 0.543 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 2.863557e-01 0.543 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 3.123534e-01 0.505 0 0
Regulation of signaling by CBL R-HSA-912631 3.434542e-01 0.464 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 3.434542e-01 0.464 0 0
CRMPs in Sema3A signaling R-HSA-399956 3.823667e-01 0.418 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 4.352584e-01 0.361 0 0
Gap junction degradation R-HSA-190873 4.352584e-01 0.361 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.227675e-01 0.282 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 5.227675e-01 0.282 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.227675e-01 0.282 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.227675e-01 0.282 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 5.227675e-01 0.282 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.287550e-01 0.483 0 0
Erythropoietin activates RAS R-HSA-9027284 4.151495e-01 0.382 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 4.151495e-01 0.382 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 4.151495e-01 0.382 0 0
Binding and entry of HIV virion R-HSA-173107 4.759536e-01 0.322 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 4.759536e-01 0.322 0 0
Folding of actin by CCT/TriC R-HSA-390450 4.759536e-01 0.322 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.844347e-01 0.415 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 4.473505e-01 0.349 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 3.501688e-01 0.456 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 4.084901e-01 0.389 0 0
Dual Incision in GG-NER R-HSA-5696400 3.935304e-01 0.405 0 0
Translation initiation complex formation R-HSA-72649 3.576146e-01 0.447 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 4.529584e-01 0.344 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 4.788135e-01 0.320 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 5.148106e-01 0.288 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 5.148106e-01 0.288 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 5.148106e-01 0.288 0 0
Signaling by APC mutants R-HSA-4839744 5.148106e-01 0.288 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 5.148106e-01 0.288 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 5.148106e-01 0.288 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 5.148106e-01 0.288 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 4.199721e-01 0.377 0 0
RUNX2 regulates bone development R-HSA-8941326 4.366948e-01 0.360 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.561221e-01 0.341 0 0
Interleukin receptor SHC signaling R-HSA-912526 4.795290e-01 0.319 0 0
Degradation of DVL R-HSA-4641258 4.580832e-01 0.339 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 5.094091e-01 0.293 0 0
EGFR downregulation R-HSA-182971 4.795466e-01 0.319 0 0
Deadenylation of mRNA R-HSA-429947 5.055795e-01 0.296 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 5.055795e-01 0.296 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 4.783465e-01 0.320 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.783465e-01 0.320 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 4.981357e-01 0.303 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 5.208241e-01 0.283 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 4.696649e-01 0.328 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 5.141345e-01 0.289 0 0
Chaperonin-mediated protein folding R-HSA-390466 5.195604e-01 0.284 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.317213e-01 0.274 0 0
Signaling by MET R-HSA-6806834 4.025044e-01 0.395 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 4.259576e-01 0.371 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 2.886764e-01 0.540 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 2.825232e-01 0.549 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 3.603316e-01 0.443 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.561221e-01 0.341 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.264332e-01 0.370 0 0
Clathrin-mediated endocytosis R-HSA-8856828 5.164195e-01 0.287 0 0
Signaling by ERBB2 R-HSA-1227986 3.316278e-01 0.479 0 0
Generation of second messenger molecules R-HSA-202433 5.208241e-01 0.283 0 0
Signalling to RAS R-HSA-167044 3.986284e-01 0.399 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 4.436336e-01 0.353 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 5.208241e-01 0.283 0 0
Chaperone Mediated Autophagy R-HSA-9613829 3.158738e-01 0.500 0 0
Myogenesis R-HSA-525793 3.603316e-01 0.443 0 0
PTEN Regulation R-HSA-6807070 2.920319e-01 0.535 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.091573e-01 0.293 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.091573e-01 0.293 0 0
Adrenoceptors R-HSA-390696 3.929116e-01 0.406 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 4.352584e-01 0.361 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 4.352584e-01 0.361 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 5.227675e-01 0.282 0 0
Regulation of gap junction activity R-HSA-191650 5.227675e-01 0.282 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 4.788135e-01 0.320 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 3.603316e-01 0.443 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 4.883579e-01 0.311 0 0
Heme signaling R-HSA-9707616 4.947241e-01 0.306 0 0
Hedgehog 'off' state R-HSA-5610787 3.958735e-01 0.402 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 3.044298e-01 0.517 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 3.986284e-01 0.399 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.233013e-01 0.490 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 3.019176e-01 0.520 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.408400e-01 0.467 0 0
Neurexins and neuroligins R-HSA-6794361 4.602068e-01 0.337 0 0
TCR signaling R-HSA-202403 4.359008e-01 0.361 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 2.825232e-01 0.549 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.884933e-01 0.540 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 3.158738e-01 0.500 0 0
Calcineurin activates NFAT R-HSA-2025928 4.352584e-01 0.361 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 5.227675e-01 0.282 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.786291e-01 0.555 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 4.759536e-01 0.322 0 0
Killing mechanisms R-HSA-9664420 4.473505e-01 0.349 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 4.473505e-01 0.349 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 4.788135e-01 0.320 0 0
Formation of the posterior neural plate R-HSA-9832991 5.148106e-01 0.288 0 0
Synthesis of PI R-HSA-1483226 5.148106e-01 0.288 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.795290e-01 0.319 0 0
MAP kinase activation R-HSA-450294 3.476100e-01 0.459 0 0
RAF/MAP kinase cascade R-HSA-5673001 4.628732e-01 0.335 1 1
Signaling by ROBO receptors R-HSA-376176 4.020719e-01 0.396 0 0
Ion homeostasis R-HSA-5578775 3.919613e-01 0.407 1 1
IGF1R signaling cascade R-HSA-2428924 5.280779e-01 0.277 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 3.955861e-01 0.403 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 4.788135e-01 0.320 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 5.055795e-01 0.296 0 0
MAPK family signaling cascades R-HSA-5683057 3.590431e-01 0.445 1 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 5.309825e-01 0.275 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.628084e-01 0.440 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.491802e-01 0.457 0 0
Lipophagy R-HSA-9613354 4.352584e-01 0.361 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 5.148106e-01 0.288 0 0
Degradation of CDH1 R-HSA-9766229 4.052162e-01 0.392 0 0
Interleukin-17 signaling R-HSA-448424 4.932659e-01 0.307 0 0
Insulin receptor signalling cascade R-HSA-74751 5.280779e-01 0.277 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 5.189019e-01 0.285 1 0
Intraflagellar transport R-HSA-5620924 3.868200e-01 0.412 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 4.778083e-01 0.321 0 0
Oncogene Induced Senescence R-HSA-2559585 4.151575e-01 0.382 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 3.995967e-01 0.398 0 0
Neurofascin interactions R-HSA-447043 3.044298e-01 0.517 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.044298e-01 0.517 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.929116e-01 0.406 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 4.561221e-01 0.341 0 0
Vesicle-mediated transport R-HSA-5653656 3.633099e-01 0.440 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 4.788135e-01 0.320 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 3.074285e-01 0.512 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 5.114410e-01 0.291 0 0
Signaling by TGFB family members R-HSA-9006936 3.573934e-01 0.447 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.091561e-01 0.510 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.892924e-01 0.410 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 3.892924e-01 0.410 0 0
C6 deamination of adenosine R-HSA-75102 3.892924e-01 0.410 0 0
Interleukin-33 signaling R-HSA-9014843 3.892924e-01 0.410 0 0
MET activates STAT3 R-HSA-8875791 4.601373e-01 0.337 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 4.601373e-01 0.337 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 3.158738e-01 0.500 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 4.352584e-01 0.361 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 4.759536e-01 0.322 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 4.759536e-01 0.322 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 3.637087e-01 0.439 0 0
Disorders of Developmental Biology R-HSA-9675151 4.788135e-01 0.320 0 0
vRNP Assembly R-HSA-192905 5.148106e-01 0.288 0 0
HSF1-dependent transactivation R-HSA-3371571 4.419479e-01 0.355 1 1
PKA activation R-HSA-163615 5.390322e-01 0.268 0 0
PKA activation in glucagon signalling R-HSA-164378 5.390322e-01 0.268 0 0
Rab regulation of trafficking R-HSA-9007101 4.488012e-01 0.348 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.971613e-01 0.527 0 0
NGF-stimulated transcription R-HSA-9031628 5.359847e-01 0.271 0 0
Signaling by FGFR in disease R-HSA-1226099 3.153154e-01 0.501 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.798944e-01 0.420 0 0
Signaling by PTK6 R-HSA-8848021 3.798944e-01 0.420 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 5.132369e-01 0.290 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 5.094091e-01 0.293 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 5.091573e-01 0.293 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 4.352584e-01 0.361 0 0
TBC/RABGAPs R-HSA-8854214 4.397205e-01 0.357 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.580832e-01 0.339 0 0
Gap junction trafficking and regulation R-HSA-157858 2.741218e-01 0.562 0 0
Negative regulation of FLT3 R-HSA-9706369 4.473505e-01 0.349 0 0
Platelet activation, signaling and aggregation R-HSA-76002 2.859671e-01 0.544 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 2.825232e-01 0.549 0 0
Signaling by LTK R-HSA-9842663 3.158236e-01 0.501 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 3.929116e-01 0.406 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 5.094091e-01 0.293 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 3.637087e-01 0.439 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 3.841696e-01 0.415 0 0
Regulation of KIT signaling R-HSA-1433559 3.823667e-01 0.418 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.354577e-01 0.474 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 4.749707e-01 0.323 0 0
HCMV Late Events R-HSA-9610379 4.072167e-01 0.390 0 0
Interferon Signaling R-HSA-913531 2.921261e-01 0.534 1 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 4.749707e-01 0.323 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 4.749707e-01 0.323 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.123534e-01 0.505 0 0
Neurodegenerative Diseases R-HSA-8863678 3.123534e-01 0.505 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 3.753523e-01 0.426 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 5.260269e-01 0.279 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.850561e-01 0.545 1 0
Mismatch Repair R-HSA-5358508 5.390322e-01 0.268 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 3.452270e-01 0.462 0 0
Gap junction trafficking R-HSA-190828 3.139887e-01 0.503 0 0
Inhibition of membrane repair R-HSA-9635644 3.091561e-01 0.510 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 3.044298e-01 0.517 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 4.601373e-01 0.337 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 3.123534e-01 0.505 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 4.352584e-01 0.361 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 3.844347e-01 0.415 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 3.844347e-01 0.415 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 5.148106e-01 0.288 0 0
Signaling by NOTCH R-HSA-157118 3.878389e-01 0.411 0 0
p75NTR signals via NF-kB R-HSA-193639 4.151495e-01 0.382 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 3.803336e-01 0.420 0 0
Sensory processing of sound R-HSA-9659379 3.877816e-01 0.411 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 3.491866e-01 0.457 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.844347e-01 0.415 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.502616e-01 0.456 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 4.013389e-01 0.396 0 0
Signaling by SCF-KIT R-HSA-1433557 2.961843e-01 0.528 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 5.317213e-01 0.274 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 3.236686e-01 0.490 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.892924e-01 0.410 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.892924e-01 0.410 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.491802e-01 0.457 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 4.601373e-01 0.337 0 0
Sodium/Proton exchangers R-HSA-425986 3.929116e-01 0.406 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 4.352584e-01 0.361 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 5.227675e-01 0.282 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.759536e-01 0.322 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 3.919613e-01 0.407 0 0
Apoptotic factor-mediated response R-HSA-111471 5.390322e-01 0.268 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 3.798944e-01 0.420 0 0
Nephron development R-HSA-9831926 3.158738e-01 0.500 0 0
Other interleukin signaling R-HSA-449836 3.434542e-01 0.464 0 0
Zinc transporters R-HSA-435354 3.823667e-01 0.418 0 0
Activation of ATR in response to replication stress R-HSA-176187 5.252817e-01 0.280 0 0
Glycolysis R-HSA-70171 3.958735e-01 0.402 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 4.529584e-01 0.344 0 0
Metal ion SLC transporters R-HSA-425410 5.359847e-01 0.271 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 3.892924e-01 0.410 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 3.491802e-01 0.457 0 0
FasL/ CD95L signaling R-HSA-75157 4.601373e-01 0.337 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.929116e-01 0.406 1 1
Respiratory syncytial virus genome replication R-HSA-9834752 4.352584e-01 0.361 0 0
Interleukin-1 processing R-HSA-448706 4.352584e-01 0.361 0 0
LGI-ADAM interactions R-HSA-5682910 5.148106e-01 0.288 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 4.792677e-01 0.319 0 0
Gap junction assembly R-HSA-190861 3.935304e-01 0.405 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.158738e-01 0.500 0 0
Insulin processing R-HSA-264876 3.844347e-01 0.415 0 0
MHC class II antigen presentation R-HSA-2132295 4.251330e-01 0.371 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 3.491866e-01 0.457 0 0
Interleukin-37 signaling R-HSA-9008059 4.561221e-01 0.341 0 0
Tie2 Signaling R-HSA-210993 5.390322e-01 0.268 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 5.094091e-01 0.293 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 3.823667e-01 0.418 0 0
Signaling by Leptin R-HSA-2586552 4.759536e-01 0.322 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 5.390322e-01 0.268 0 0
Switching of origins to a post-replicative state R-HSA-69052 5.404766e-01 0.267 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.411063e-01 0.267 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 5.444664e-01 0.264 0 0
IRS-mediated signalling R-HSA-112399 5.490656e-01 0.260 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.517082e-01 0.258 0 0
ERKs are inactivated R-HSA-202670 5.517082e-01 0.258 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 5.517082e-01 0.258 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 5.517082e-01 0.258 0 0
NF-kB is activated and signals survival R-HSA-209560 5.517082e-01 0.258 0 0
Signaling by AMER1 mutants R-HSA-4839748 5.517082e-01 0.258 0 0
Signaling by AXIN mutants R-HSA-4839735 5.517082e-01 0.258 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 5.517082e-01 0.258 0 0
DNA Damage Bypass R-HSA-73893 5.544750e-01 0.256 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 5.544750e-01 0.256 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 5.558197e-01 0.255 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 5.558197e-01 0.255 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 5.610051e-01 0.251 0 0
HIV Transcription Initiation R-HSA-167161 5.610051e-01 0.251 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 5.610051e-01 0.251 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 5.676003e-01 0.246 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 5.676003e-01 0.246 0 0
E2F mediated regulation of DNA replication R-HSA-113510 5.676003e-01 0.246 0 0
Germ layer formation at gastrulation R-HSA-9754189 5.676003e-01 0.246 0 0
Rap1 signalling R-HSA-392517 5.676003e-01 0.246 0 0
Maturation of nucleoprotein R-HSA-9694631 5.676003e-01 0.246 0 0
The NLRP3 inflammasome R-HSA-844456 5.676003e-01 0.246 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 5.676003e-01 0.246 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 5.691682e-01 0.245 0 0
Mitophagy R-HSA-5205647 5.691682e-01 0.245 0 0
PI3K Cascade R-HSA-109704 5.726354e-01 0.242 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 5.761134e-01 0.239 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 5.781352e-01 0.238 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.781352e-01 0.238 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.781352e-01 0.238 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 5.781352e-01 0.238 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.781352e-01 0.238 0 0
PTK6 Down-Regulation R-HSA-8849472 5.781352e-01 0.238 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.781352e-01 0.238 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.781352e-01 0.238 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 5.781352e-01 0.238 0 0
Pyrophosphate hydrolysis R-HSA-71737 5.781352e-01 0.238 0 0
Interleukin-36 pathway R-HSA-9014826 5.781352e-01 0.238 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 5.781352e-01 0.238 0 0
NrCAM interactions R-HSA-447038 5.781352e-01 0.238 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.798871e-01 0.237 0 0
Signaling by FGFR3 in disease R-HSA-5655332 5.798871e-01 0.237 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 5.804861e-01 0.236 0 0
Post-translational protein phosphorylation R-HSA-8957275 5.844798e-01 0.233 0 0
UCH proteinases R-HSA-5689603 5.860017e-01 0.232 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 5.865782e-01 0.232 0 0
Leading Strand Synthesis R-HSA-69109 5.865782e-01 0.232 0 0
Polymerase switching R-HSA-69091 5.865782e-01 0.232 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 5.865782e-01 0.232 0 0
Interleukin-15 signaling R-HSA-8983432 5.865782e-01 0.232 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 5.865782e-01 0.232 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.865782e-01 0.232 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 5.865782e-01 0.232 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.865782e-01 0.232 0 0
Regulation of IFNG signaling R-HSA-877312 5.865782e-01 0.232 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.865782e-01 0.232 0 0
Pervasive developmental disorders R-HSA-9005895 5.865782e-01 0.232 0 0
Disorders of Nervous System Development R-HSA-9697154 5.865782e-01 0.232 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 5.865782e-01 0.232 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 5.865782e-01 0.232 0 0
SARS-CoV-1-host interactions R-HSA-9692914 5.926752e-01 0.227 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 5.946780e-01 0.226 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 5.950511e-01 0.225 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 5.950511e-01 0.225 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 5.950511e-01 0.225 0 0
Signal transduction by L1 R-HSA-445144 5.950511e-01 0.225 0 0
FOXO-mediated transcription R-HSA-9614085 5.974524e-01 0.224 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 5.995191e-01 0.222 0 0
Signaling by FGFR4 R-HSA-5654743 5.995191e-01 0.222 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 5.995191e-01 0.222 0 0
SARS-CoV-1 Infection R-HSA-9678108 6.025136e-01 0.220 0 0
Protein folding R-HSA-391251 6.027237e-01 0.220 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 6.031885e-01 0.220 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 6.031885e-01 0.220 0 0
Pyroptosis R-HSA-5620971 6.031885e-01 0.220 0 0
Synthesis of DNA R-HSA-69239 6.050800e-01 0.218 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 6.078633e-01 0.216 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.085897e-01 0.216 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 6.102570e-01 0.214 0 0
GPVI-mediated activation cascade R-HSA-114604 6.108599e-01 0.214 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 6.122623e-01 0.213 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 6.144948e-01 0.211 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 6.173116e-01 0.209 0 0
RMTs methylate histone arginines R-HSA-3214858 6.180777e-01 0.209 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 6.190577e-01 0.208 0 0
Processing of SMDT1 R-HSA-8949664 6.193943e-01 0.208 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 6.193943e-01 0.208 0 0
Maturation of nucleoprotein R-HSA-9683610 6.193943e-01 0.208 0 0
Lagging Strand Synthesis R-HSA-69186 6.213401e-01 0.207 0 0
Basigin interactions R-HSA-210991 6.213401e-01 0.207 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 6.213401e-01 0.207 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 6.213401e-01 0.207 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 6.226810e-01 0.206 0 0
Amino acids regulate mTORC1 R-HSA-9639288 6.248861e-01 0.204 0 0
Late endosomal microautophagy R-HSA-9615710 6.256880e-01 0.204 0 0
Termination of translesion DNA synthesis R-HSA-5656169 6.256880e-01 0.204 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 6.256880e-01 0.204 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.270820e-01 0.203 0 0
NGF-independant TRKA activation R-HSA-187024 6.270820e-01 0.203 0 0
Plus-strand DNA synthesis R-HSA-164525 6.270820e-01 0.203 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 6.270820e-01 0.203 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.270820e-01 0.203 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.270820e-01 0.203 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.270820e-01 0.203 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.270820e-01 0.203 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 6.270820e-01 0.203 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 6.270820e-01 0.203 0 0
Terminal pathway of complement R-HSA-166665 6.270820e-01 0.203 0 0
Signaling by MST1 R-HSA-8852405 6.270820e-01 0.203 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 6.270820e-01 0.203 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.270820e-01 0.203 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 6.270820e-01 0.203 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 6.270820e-01 0.203 0 0
Intestinal hexose absorption R-HSA-8981373 6.270820e-01 0.203 0 0
VEGF ligand-receptor interactions R-HSA-194313 6.270820e-01 0.203 0 0
Relaxin receptors R-HSA-444821 6.270820e-01 0.203 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 6.270820e-01 0.203 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 6.270820e-01 0.203 0 0
TRAIL signaling R-HSA-75158 6.270820e-01 0.203 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 6.289314e-01 0.201 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 6.293789e-01 0.201 0 0
NCAM signaling for neurite out-growth R-HSA-375165 6.313318e-01 0.200 0 0
Signaling by PDGF R-HSA-186797 6.313318e-01 0.200 0 0
PI Metabolism R-HSA-1483255 6.352334e-01 0.197 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 6.361395e-01 0.196 0 0
Fanconi Anemia Pathway R-HSA-6783310 6.361395e-01 0.196 0 0
Signaling by FGFR3 R-HSA-5654741 6.361395e-01 0.196 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 6.432959e-01 0.192 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 6.464390e-01 0.189 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 6.464390e-01 0.189 0 0
Glucose metabolism R-HSA-70326 6.469324e-01 0.189 0 0
DAP12 signaling R-HSA-2424491 6.473581e-01 0.189 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 6.473581e-01 0.189 0 0
Activation of BH3-only proteins R-HSA-114452 6.473581e-01 0.189 0 0
Retrograde neurotrophin signalling R-HSA-177504 6.501636e-01 0.187 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 6.501636e-01 0.187 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 6.501636e-01 0.187 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 6.536860e-01 0.185 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 6.536860e-01 0.185 0 0
Budding and maturation of HIV virion R-HSA-162588 6.681797e-01 0.175 0 0
Stabilization of p53 R-HSA-69541 6.687604e-01 0.175 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 6.691282e-01 0.174 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 6.691282e-01 0.174 0 0
rRNA processing R-HSA-72312 6.701719e-01 0.174 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 6.703333e-01 0.174 0 0
FGFR2 alternative splicing R-HSA-6803529 6.703333e-01 0.174 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 6.703333e-01 0.174 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 6.703333e-01 0.174 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 6.703333e-01 0.174 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 6.703333e-01 0.174 0 0
Signaling by KIT in disease R-HSA-9669938 6.703333e-01 0.174 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 6.703333e-01 0.174 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.703523e-01 0.174 0 0
STAT5 Activation R-HSA-9645135 6.703523e-01 0.174 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.703523e-01 0.174 0 0
Uncoating of the HIV Virion R-HSA-162585 6.703523e-01 0.174 0 0
Metabolism of ingested MeSeO2H into MeSeH R-HSA-5263617 6.703523e-01 0.174 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 6.703523e-01 0.174 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 6.703523e-01 0.174 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 6.703523e-01 0.174 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 6.703523e-01 0.174 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 6.703523e-01 0.174 0 0
MET Receptor Activation R-HSA-6806942 6.703523e-01 0.174 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 6.703523e-01 0.174 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.703523e-01 0.174 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.703523e-01 0.174 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.703523e-01 0.174 0 0
Agmatine biosynthesis R-HSA-351143 6.703523e-01 0.174 0 0
Nef and signal transduction R-HSA-164944 6.703523e-01 0.174 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 6.707018e-01 0.173 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 6.707018e-01 0.173 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 6.707018e-01 0.173 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 6.707018e-01 0.173 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 6.764751e-01 0.170 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.789194e-01 0.168 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 6.789194e-01 0.168 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 6.789194e-01 0.168 0 0
Translesion synthesis by REV1 R-HSA-110312 6.789194e-01 0.168 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.789194e-01 0.168 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 6.789194e-01 0.168 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 6.789194e-01 0.168 0 0
p38MAPK events R-HSA-171007 6.789194e-01 0.168 0 0
Spry regulation of FGF signaling R-HSA-1295596 6.789194e-01 0.168 0 0
Formation of the anterior neural plate R-HSA-9823739 6.789194e-01 0.168 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 6.789194e-01 0.168 0 0
DNA Damage Reversal R-HSA-73942 6.789194e-01 0.168 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 6.825792e-01 0.166 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 6.871751e-01 0.163 0 0
DNA strand elongation R-HSA-69190 6.881408e-01 0.162 0 0
Signaling by WNT in cancer R-HSA-4791275 6.881408e-01 0.162 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 6.886435e-01 0.162 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 6.930204e-01 0.159 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 6.930204e-01 0.159 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 6.930204e-01 0.159 0 0
Syndecan interactions R-HSA-3000170 6.930204e-01 0.159 0 0
Growth hormone receptor signaling R-HSA-982772 6.930204e-01 0.159 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 6.936502e-01 0.159 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.009317e-01 0.154 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.009317e-01 0.154 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 7.034407e-01 0.153 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 7.040613e-01 0.152 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 7.057145e-01 0.151 0 0
Regulation of BACH1 activity R-HSA-9708530 7.057145e-01 0.151 0 0
Translesion synthesis by POLI R-HSA-5656121 7.057145e-01 0.151 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 7.057145e-01 0.151 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 7.057145e-01 0.151 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 7.057145e-01 0.151 0 0
Signaling by NOTCH1 R-HSA-1980143 7.063047e-01 0.151 0 0
Integrin signaling R-HSA-354192 7.072360e-01 0.150 0 0
IFNG signaling activates MAPKs R-HSA-9732724 7.086041e-01 0.150 0 0
DAG1 core M1 glycosylations R-HSA-8932506 7.086041e-01 0.150 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 7.086041e-01 0.150 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 7.086041e-01 0.150 0 0
PTK6 Expression R-HSA-8849473 7.086041e-01 0.150 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.086041e-01 0.150 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 7.086041e-01 0.150 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.086041e-01 0.150 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.086041e-01 0.150 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 7.086041e-01 0.150 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 7.086041e-01 0.150 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 7.086041e-01 0.150 0 0
CHL1 interactions R-HSA-447041 7.086041e-01 0.150 0 0
Signaling by Insulin receptor R-HSA-74752 7.106677e-01 0.148 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 7.145081e-01 0.146 0 0
TNFs bind their physiological receptors R-HSA-5669034 7.145081e-01 0.146 0 0
Cytokine Signaling in Immune system R-HSA-1280215 7.153552e-01 0.145 1 0
Transmission across Chemical Synapses R-HSA-112315 7.161465e-01 0.145 1 0
Signaling by Hedgehog R-HSA-5358351 7.172785e-01 0.144 0 0
Regulation of beta-cell development R-HSA-186712 7.177659e-01 0.144 0 0
Signaling by FGFR2 in disease R-HSA-5655253 7.184626e-01 0.144 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 7.203275e-01 0.142 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 7.206961e-01 0.142 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 7.206961e-01 0.142 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 7.206961e-01 0.142 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 7.206961e-01 0.142 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 7.233479e-01 0.141 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 7.254658e-01 0.139 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 7.254658e-01 0.139 0 0
Cap-dependent Translation Initiation R-HSA-72737 7.285097e-01 0.138 0 0
Eukaryotic Translation Initiation R-HSA-72613 7.285097e-01 0.138 0 0
Translesion synthesis by POLK R-HSA-5655862 7.306168e-01 0.136 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 7.306168e-01 0.136 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 7.316151e-01 0.136 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 7.316151e-01 0.136 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 7.316151e-01 0.136 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 7.316151e-01 0.136 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 7.316151e-01 0.136 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 7.348129e-01 0.134 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 7.348129e-01 0.134 0 0
TGFBR3 expression R-HSA-9839394 7.348129e-01 0.134 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 7.348129e-01 0.134 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 7.348129e-01 0.134 0 0
Reverse Transcription of HIV RNA R-HSA-162589 7.424192e-01 0.129 0 0
Minus-strand DNA synthesis R-HSA-164516 7.424192e-01 0.129 0 0
Regulation by c-FLIP R-HSA-3371378 7.424192e-01 0.129 0 0
phospho-PLA2 pathway R-HSA-111995 7.424192e-01 0.129 0 0
DAG1 core M2 glycosylations R-HSA-8932504 7.424192e-01 0.129 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.424192e-01 0.129 0 0
Dimerization of procaspase-8 R-HSA-69416 7.424192e-01 0.129 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.424192e-01 0.129 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.424192e-01 0.129 0 0
Interleukin-9 signaling R-HSA-8985947 7.424192e-01 0.129 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.424192e-01 0.129 0 0
Activation of RAS in B cells R-HSA-1169092 7.424192e-01 0.129 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 7.424192e-01 0.129 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 7.424192e-01 0.129 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 7.424192e-01 0.129 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.424192e-01 0.129 0 0
Intestinal absorption R-HSA-8963676 7.424192e-01 0.129 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 7.428359e-01 0.129 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 7.428359e-01 0.129 0 0
Toll-like Receptor Cascades R-HSA-168898 7.428618e-01 0.129 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 7.437196e-01 0.129 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 7.449864e-01 0.128 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 7.475127e-01 0.126 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.475127e-01 0.126 0 0
Response of Mtb to phagocytosis R-HSA-9637690 7.519306e-01 0.124 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.537046e-01 0.123 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 7.537046e-01 0.123 0 0
Specification of primordial germ cells R-HSA-9827857 7.537046e-01 0.123 0 0
Uptake and function of anthrax toxins R-HSA-5210891 7.537046e-01 0.123 0 0
Metalloprotease DUBs R-HSA-5689901 7.539585e-01 0.123 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.539585e-01 0.123 0 0
Signaling by FGFR2 R-HSA-5654738 7.549291e-01 0.122 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 7.554447e-01 0.122 0 0
Opioid Signalling R-HSA-111885 7.554447e-01 0.122 1 0
Inositol phosphate metabolism R-HSA-1483249 7.563464e-01 0.121 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 7.578798e-01 0.120 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 7.593563e-01 0.120 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.593563e-01 0.120 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.611987e-01 0.119 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 7.677136e-01 0.115 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 7.702968e-01 0.113 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.719746e-01 0.112 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 7.719746e-01 0.112 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 7.719746e-01 0.112 0 0
CASP8 activity is inhibited R-HSA-5218900 7.723120e-01 0.112 0 0
Interleukin-21 signaling R-HSA-9020958 7.723120e-01 0.112 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.723120e-01 0.112 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.723120e-01 0.112 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.723120e-01 0.112 0 0
Unwinding of DNA R-HSA-176974 7.723120e-01 0.112 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.723120e-01 0.112 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.723120e-01 0.112 0 0
mRNA Editing R-HSA-75072 7.723120e-01 0.112 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.723120e-01 0.112 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.723120e-01 0.112 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 7.743299e-01 0.111 0 0
Platelet sensitization by LDL R-HSA-432142 7.750637e-01 0.111 0 0
Polo-like kinase mediated events R-HSA-156711 7.750637e-01 0.111 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 7.804839e-01 0.108 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 7.804839e-01 0.108 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 7.804839e-01 0.108 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 7.841254e-01 0.106 0 0
Insulin receptor recycling R-HSA-77387 7.888957e-01 0.103 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 7.888957e-01 0.103 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 7.888957e-01 0.103 1 1
Inflammasomes R-HSA-622312 7.888957e-01 0.103 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 7.899080e-01 0.102 0 0
Ion channel transport R-HSA-983712 7.918848e-01 0.101 1 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 7.947842e-01 0.100 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 7.947842e-01 0.100 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.947842e-01 0.100 0 0
Specification of the neural plate border R-HSA-9834899 7.947842e-01 0.100 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.987372e-01 0.098 0 0
Receptor Mediated Mitophagy R-HSA-8934903 7.987372e-01 0.098 0 0
DNA replication initiation R-HSA-68952 7.987372e-01 0.098 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.987372e-01 0.098 0 0
Arachidonate production from DAG R-HSA-426048 7.987372e-01 0.098 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.987372e-01 0.098 0 0
Signaling by FGFR1 R-HSA-5654736 7.989523e-01 0.097 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 8.020875e-01 0.096 0 0
MET promotes cell motility R-HSA-8875878 8.039769e-01 0.095 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 8.047597e-01 0.094 0 0
mRNA Capping R-HSA-72086 8.047597e-01 0.094 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 8.047597e-01 0.094 0 0
DARPP-32 events R-HSA-180024 8.047597e-01 0.094 0 0
Platelet calcium homeostasis R-HSA-418360 8.047597e-01 0.094 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 8.064313e-01 0.093 0 0
Circadian clock R-HSA-9909396 8.086688e-01 0.092 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.101995e-01 0.091 0 0
Interleukin-12 signaling R-HSA-9020591 8.107451e-01 0.091 0 0
Signaling by NODAL R-HSA-1181150 8.129587e-01 0.090 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 8.129587e-01 0.090 0 0
Developmental Biology R-HSA-1266738 8.147747e-01 0.089 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.159428e-01 0.088 0 0
G1/S Transition R-HSA-69206 8.167307e-01 0.088 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 8.168145e-01 0.088 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 8.172704e-01 0.088 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 8.172704e-01 0.088 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.172704e-01 0.088 0 0
Co-stimulation by CD28 R-HSA-389356 8.184604e-01 0.087 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 8.196077e-01 0.086 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.196077e-01 0.086 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.204935e-01 0.086 0 0
SARS-CoV-2-host interactions R-HSA-9705683 8.214282e-01 0.085 0 0
PECAM1 interactions R-HSA-210990 8.220969e-01 0.085 0 0
DAG1 core M3 glycosylations R-HSA-8932505 8.220969e-01 0.085 0 0
Interleukin-2 signaling R-HSA-9020558 8.220969e-01 0.085 0 0
vRNA Synthesis R-HSA-192814 8.220969e-01 0.085 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 8.220969e-01 0.085 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.220969e-01 0.085 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.220969e-01 0.085 0 0
Transport of RCbl within the body R-HSA-9758890 8.220969e-01 0.085 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.220969e-01 0.085 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.220969e-01 0.085 0 0
Regulated Necrosis R-HSA-5218859 8.253897e-01 0.083 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 8.296804e-01 0.081 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 8.296804e-01 0.081 0 0
Interleukin-2 family signaling R-HSA-451927 8.298131e-01 0.081 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.298131e-01 0.081 0 0
Diseases of Immune System R-HSA-5260271 8.298131e-01 0.081 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 8.298131e-01 0.081 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 8.298131e-01 0.081 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 8.298806e-01 0.081 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 8.298806e-01 0.081 0 0
Muscle contraction R-HSA-397014 8.312449e-01 0.080 1 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.334826e-01 0.079 0 0
Neutrophil degranulation R-HSA-6798695 8.368246e-01 0.077 0 0
Regulation of RAS by GAPs R-HSA-5658442 8.407090e-01 0.075 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.418948e-01 0.075 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 8.427465e-01 0.074 0 0
DS-GAG biosynthesis R-HSA-2022923 8.427465e-01 0.074 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.427465e-01 0.074 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 8.427465e-01 0.074 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 8.427465e-01 0.074 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.427465e-01 0.074 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.427465e-01 0.074 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.427465e-01 0.074 0 0
Sodium/Calcium exchangers R-HSA-425561 8.427465e-01 0.074 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 8.427465e-01 0.074 0 0
Integration of energy metabolism R-HSA-163685 8.441704e-01 0.074 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 8.442949e-01 0.074 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 8.450416e-01 0.073 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 8.450416e-01 0.073 0 0
Assembly Of The HIV Virion R-HSA-175474 8.450416e-01 0.073 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.464285e-01 0.072 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 8.509638e-01 0.070 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.527505e-01 0.069 0 0
Negative regulation of MAPK pathway R-HSA-5675221 8.527505e-01 0.069 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.584904e-01 0.066 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.584904e-01 0.066 0 0
Downstream TCR signaling R-HSA-202424 8.586588e-01 0.066 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 8.591328e-01 0.066 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.591328e-01 0.066 0 0
Cellular hexose transport R-HSA-189200 8.591328e-01 0.066 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 8.591328e-01 0.066 0 0
Orc1 removal from chromatin R-HSA-68949 8.606639e-01 0.065 0 0
Maple Syrup Urine Disease R-HSA-9865114 8.610003e-01 0.065 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.610003e-01 0.065 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.610003e-01 0.065 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.610003e-01 0.065 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 8.610003e-01 0.065 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.610003e-01 0.065 0 0
p75NTR recruits signalling complexes R-HSA-209543 8.610003e-01 0.065 0 0
OAS antiviral response R-HSA-8983711 8.610003e-01 0.065 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.632001e-01 0.064 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 8.632001e-01 0.064 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 8.632001e-01 0.064 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.688880e-01 0.061 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.697134e-01 0.061 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.697134e-01 0.061 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.697134e-01 0.061 0 0
Smooth Muscle Contraction R-HSA-445355 8.698290e-01 0.061 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 8.720417e-01 0.059 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 8.720417e-01 0.059 0 0
ABC-family proteins mediated transport R-HSA-382556 8.755705e-01 0.058 0 0
SARS-CoV Infections R-HSA-9679506 8.760457e-01 0.057 0 0
Interferon gamma signaling R-HSA-877300 8.768489e-01 0.057 1 1
OGDH complex synthesizes succinyl-CoA from 2-OG R-HSA-9853506 8.771362e-01 0.057 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 8.771362e-01 0.057 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 8.771362e-01 0.057 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 8.771362e-01 0.057 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.771362e-01 0.057 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.771362e-01 0.057 0 0
rRNA modification in the mitochondrion R-HSA-6793080 8.771362e-01 0.057 0 0
Interleukin-6 signaling R-HSA-1059683 8.771362e-01 0.057 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 8.801424e-01 0.055 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.801424e-01 0.055 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.801424e-01 0.055 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.801424e-01 0.055 0 0
Calnexin/calreticulin cycle R-HSA-901042 8.801424e-01 0.055 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 8.819482e-01 0.055 0 0
DAP12 interactions R-HSA-2172127 8.822021e-01 0.054 0 0
Proteasome assembly R-HSA-9907900 8.822021e-01 0.054 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 8.838529e-01 0.054 0 0
Cellular response to chemical stress R-HSA-9711123 8.847724e-01 0.053 0 0
G alpha (z) signalling events R-HSA-418597 8.866340e-01 0.052 0 0
Influenza Infection R-HSA-168255 8.891080e-01 0.051 0 0
tRNA processing R-HSA-72306 8.902793e-01 0.050 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 8.908116e-01 0.050 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 8.908116e-01 0.050 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 8.908116e-01 0.050 0 0
Removal of the Flap Intermediate R-HSA-69166 8.913998e-01 0.050 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 8.913998e-01 0.050 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 8.913998e-01 0.050 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 8.913998e-01 0.050 0 0
Hydrolysis of LPC R-HSA-1483115 8.913998e-01 0.050 0 0
cGMP effects R-HSA-418457 8.913998e-01 0.050 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 8.913998e-01 0.050 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.913998e-01 0.050 0 0
Physiological factors R-HSA-5578768 8.913998e-01 0.050 0 0
Non-canonical inflammasome activation R-HSA-9686114 8.913998e-01 0.050 0 0
HDL assembly R-HSA-8963896 8.913998e-01 0.050 0 0
Signal regulatory protein family interactions R-HSA-391160 8.913998e-01 0.050 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.913998e-01 0.050 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.946473e-01 0.048 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 8.946473e-01 0.048 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.946473e-01 0.048 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.946473e-01 0.048 0 0
Hyaluronan degradation R-HSA-2160916 8.946473e-01 0.048 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.987946e-01 0.046 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.987946e-01 0.046 0 0
HSF1 activation R-HSA-3371511 8.987946e-01 0.046 0 0
G1/S-Specific Transcription R-HSA-69205 8.987946e-01 0.046 0 0
Signaling by TGFBR3 R-HSA-9839373 8.988647e-01 0.046 0 0
Interleukin-12 family signaling R-HSA-447115 9.036558e-01 0.044 0 0
Signaling by Activin R-HSA-1502540 9.040082e-01 0.044 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 9.040082e-01 0.044 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 9.040082e-01 0.044 0 0
Protein methylation R-HSA-8876725 9.040082e-01 0.044 0 0
Other semaphorin interactions R-HSA-416700 9.040082e-01 0.044 0 0
Integrin cell surface interactions R-HSA-216083 9.040429e-01 0.044 0 0
MET activates PTK2 signaling R-HSA-8874081 9.045017e-01 0.044 0 0
Sphingolipid catabolism R-HSA-9845614 9.045017e-01 0.044 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.045017e-01 0.044 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.071035e-01 0.042 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.093424e-01 0.041 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 9.115914e-01 0.040 0 0
SLC transporter disorders R-HSA-5619102 9.131239e-01 0.039 0 0
Gluconeogenesis R-HSA-70263 9.134132e-01 0.039 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 9.134887e-01 0.039 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.134887e-01 0.039 0 0
Adipogenesis R-HSA-9843745 9.136646e-01 0.039 0 0
Adaptive Immune System R-HSA-1280218 9.143333e-01 0.039 0 0
Extension of Telomeres R-HSA-180786 9.147127e-01 0.039 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.147127e-01 0.039 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.147892e-01 0.039 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.147892e-01 0.039 0 0
Cellular response to starvation R-HSA-9711097 9.149496e-01 0.039 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 9.151535e-01 0.039 0 0
Attachment and Entry R-HSA-9678110 9.151535e-01 0.039 0 0
Phase 4 - resting membrane potential R-HSA-5576886 9.151535e-01 0.039 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 9.151535e-01 0.039 0 0
Activation of SMO R-HSA-5635838 9.151535e-01 0.039 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 9.151535e-01 0.039 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.152865e-01 0.038 0 0
Parasite infection R-HSA-9664407 9.152865e-01 0.038 0 0
Leishmania phagocytosis R-HSA-9664417 9.152865e-01 0.038 0 0
Signaling by FGFR R-HSA-190236 9.192934e-01 0.037 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.199629e-01 0.036 0 0
Viral Infection Pathways R-HSA-9824446 9.206690e-01 0.036 0 0
RAB geranylgeranylation R-HSA-8873719 9.206975e-01 0.036 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.207558e-01 0.036 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.216770e-01 0.035 0 0
Pyrimidine salvage R-HSA-73614 9.216770e-01 0.035 0 0
Hedgehog 'on' state R-HSA-5632684 9.228408e-01 0.035 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.250053e-01 0.034 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.250053e-01 0.034 0 0
Glycine degradation R-HSA-6783984 9.250053e-01 0.034 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 9.250053e-01 0.034 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 9.250053e-01 0.034 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.250053e-01 0.034 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.250053e-01 0.034 0 0
Synthesis of PG R-HSA-1483148 9.250053e-01 0.034 0 0
Coenzyme A biosynthesis R-HSA-196783 9.250053e-01 0.034 0 0
Glycogen metabolism R-HSA-8982491 9.284478e-01 0.032 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.284478e-01 0.032 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.284478e-01 0.032 0 0
Attenuation phase R-HSA-3371568 9.284478e-01 0.032 0 0
Developmental Cell Lineages R-HSA-9734767 9.287232e-01 0.032 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.304404e-01 0.031 0 0
Interleukin-1 signaling R-HSA-9020702 9.324613e-01 0.030 0 0
Ca2+ pathway R-HSA-4086398 9.328143e-01 0.030 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 9.337136e-01 0.030 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.337136e-01 0.030 0 0
Glycogen storage diseases R-HSA-3229121 9.337136e-01 0.030 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.337136e-01 0.030 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.337136e-01 0.030 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.344948e-01 0.029 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.344948e-01 0.029 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 9.358785e-01 0.029 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 9.359102e-01 0.029 0 0
Signaling by Interleukins R-HSA-449147 9.365512e-01 0.028 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.368320e-01 0.028 0 0
Signaling by ERBB4 R-HSA-1236394 9.373594e-01 0.028 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.398784e-01 0.027 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.400671e-01 0.027 0 0
Intra-Golgi traffic R-HSA-6811438 9.400671e-01 0.027 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.410771e-01 0.026 0 0
Synaptic adhesion-like molecules R-HSA-8849932 9.414113e-01 0.026 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.414113e-01 0.026 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.414113e-01 0.026 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.420713e-01 0.026 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.420713e-01 0.026 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 9.420713e-01 0.026 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.437235e-01 0.025 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 9.464901e-01 0.024 0 0
DAG1 glycosylations R-HSA-8931838 9.476663e-01 0.023 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.476663e-01 0.023 0 0
Translesion Synthesis by POLH R-HSA-110320 9.482154e-01 0.023 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.482154e-01 0.023 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.482154e-01 0.023 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.482154e-01 0.023 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 9.482154e-01 0.023 0 0
Gastrulation R-HSA-9758941 9.490759e-01 0.023 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.493832e-01 0.023 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.499168e-01 0.022 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.516136e-01 0.022 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 9.527435e-01 0.021 0 0
Cardiogenesis R-HSA-9733709 9.527435e-01 0.021 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.531245e-01 0.021 0 0
Kidney development R-HSA-9830369 9.531245e-01 0.021 0 0
Glycogen synthesis R-HSA-3322077 9.542296e-01 0.020 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.542296e-01 0.020 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.542296e-01 0.020 0 0
Protein hydroxylation R-HSA-9629569 9.542296e-01 0.020 0 0
Amine ligand-binding receptors R-HSA-375280 9.542550e-01 0.020 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.549858e-01 0.020 0 0
Interleukin-1 family signaling R-HSA-446652 9.566041e-01 0.019 0 0
ER-Phagosome pathway R-HSA-1236974 9.566373e-01 0.019 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.573476e-01 0.019 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.573476e-01 0.019 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.573476e-01 0.019 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.582396e-01 0.019 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.582396e-01 0.019 0 0
Somitogenesis R-HSA-9824272 9.582396e-01 0.019 0 0
Stimuli-sensing channels R-HSA-2672351 9.588547e-01 0.018 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.595457e-01 0.018 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.595457e-01 0.018 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 9.595457e-01 0.018 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.595457e-01 0.018 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.595457e-01 0.018 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.595457e-01 0.018 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.595457e-01 0.018 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.595457e-01 0.018 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.595457e-01 0.018 0 0
Peptide hormone metabolism R-HSA-2980736 9.603401e-01 0.018 0 0
Mitochondrial biogenesis R-HSA-1592230 9.603401e-01 0.018 0 0
Hemostasis R-HSA-109582 9.605185e-01 0.017 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.615201e-01 0.017 0 0
Signaling by NOTCH2 R-HSA-1980145 9.615201e-01 0.017 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 9.615201e-01 0.017 0 0
Hyaluronan metabolism R-HSA-2142845 9.615201e-01 0.017 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.615201e-01 0.017 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.615201e-01 0.017 0 0
NOD1/2 Signaling Pathway R-HSA-168638 9.615201e-01 0.017 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.616216e-01 0.017 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.618968e-01 0.017 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.618968e-01 0.017 0 0
COPII-mediated vesicle transport R-HSA-204005 9.628857e-01 0.016 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.628857e-01 0.016 0 0
PPARA activates gene expression R-HSA-1989781 9.631380e-01 0.016 0 0
CS-GAG biosynthesis R-HSA-2022870 9.642446e-01 0.016 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.642446e-01 0.016 0 0
Attachment and Entry R-HSA-9694614 9.642446e-01 0.016 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.642446e-01 0.016 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.642446e-01 0.016 0 0
Serine metabolism R-HSA-977347 9.642446e-01 0.016 0 0
Synthesis of PC R-HSA-1483191 9.652511e-01 0.015 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.652991e-01 0.015 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.652991e-01 0.015 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.652991e-01 0.015 0 0
Regulation of Apoptosis R-HSA-169911 9.652991e-01 0.015 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.656783e-01 0.015 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.669955e-01 0.015 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.672503e-01 0.014 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.674245e-01 0.014 0 0
tRNA Aminoacylation R-HSA-379724 9.675991e-01 0.014 0 0
Neuronal System R-HSA-112316 9.681763e-01 0.014 1 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.682221e-01 0.014 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.682221e-01 0.014 0 0
GPER1 signaling R-HSA-9634597 9.683255e-01 0.014 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.683980e-01 0.014 0 0
LDL clearance R-HSA-8964038 9.683980e-01 0.014 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.683980e-01 0.014 0 0
Ethanol oxidation R-HSA-71384 9.683980e-01 0.014 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.687197e-01 0.014 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.687197e-01 0.014 0 0
Aquaporin-mediated transport R-HSA-445717 9.702510e-01 0.013 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.711415e-01 0.013 0 0
Post-translational protein modification R-HSA-597592 9.716285e-01 0.012 0 0
Degradation of AXIN R-HSA-4641257 9.718141e-01 0.012 0 0
Cardiac conduction R-HSA-5576891 9.719177e-01 0.012 1 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.720691e-01 0.012 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.720691e-01 0.012 0 0
Carnitine shuttle R-HSA-200425 9.720691e-01 0.012 0 0
Interleukin-20 family signaling R-HSA-8854691 9.720691e-01 0.012 0 0
Signaling by NOTCH4 R-HSA-9013694 9.730017e-01 0.012 0 0
RSV-host interactions R-HSA-9833110 9.736034e-01 0.012 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.746119e-01 0.011 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.746119e-01 0.011 0 0
Elastic fibre formation R-HSA-1566948 9.746119e-01 0.011 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.753140e-01 0.011 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.753140e-01 0.011 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.753140e-01 0.011 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.753140e-01 0.011 0 0
Interleukin-6 family signaling R-HSA-6783589 9.753140e-01 0.011 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.754425e-01 0.011 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.754900e-01 0.011 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.760772e-01 0.011 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.760772e-01 0.011 0 0
RAS processing R-HSA-9648002 9.771403e-01 0.010 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.771403e-01 0.010 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.771403e-01 0.010 0 0
Formation of the nephric duct R-HSA-9830364 9.781820e-01 0.010 0 0
Cellular response to hypoxia R-HSA-1234174 9.789568e-01 0.009 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 9.794240e-01 0.009 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.794240e-01 0.009 0 0
Tryptophan catabolism R-HSA-71240 9.794240e-01 0.009 0 0
Regulation of insulin secretion R-HSA-422356 9.802990e-01 0.009 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.807170e-01 0.008 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.807170e-01 0.008 0 0
TRP channels R-HSA-3295583 9.807170e-01 0.008 0 0
Urea cycle R-HSA-70635 9.807170e-01 0.008 0 0
Linoleic acid (LA) metabolism R-HSA-2046105 9.807170e-01 0.008 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.807170e-01 0.008 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 9.807170e-01 0.008 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.814859e-01 0.008 0 0
Neurotransmitter release cycle R-HSA-112310 9.823544e-01 0.008 0 0
Cristae formation R-HSA-8949613 9.829576e-01 0.007 0 0
Signaling by BMP R-HSA-201451 9.829576e-01 0.007 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.829576e-01 0.007 0 0
Triglyceride biosynthesis R-HSA-75109 9.829576e-01 0.007 0 0
Synthesis of PE R-HSA-1483213 9.829576e-01 0.007 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.833466e-01 0.007 0 0
Translation of Structural Proteins R-HSA-9683701 9.833466e-01 0.007 0 0
Signaling by NOTCH3 R-HSA-9012852 9.836443e-01 0.007 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.849252e-01 0.007 0 0
Telomere Extension By Telomerase R-HSA-171319 9.849379e-01 0.007 0 0
Iron assimilation using enterobactin R-HSA-9638334 9.849379e-01 0.007 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.851423e-01 0.007 0 0
Leishmania infection R-HSA-9658195 9.859784e-01 0.006 0 0
Parasitic Infection Pathways R-HSA-9824443 9.859784e-01 0.006 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.865382e-01 0.006 0 0
Glucagon-type ligand receptors R-HSA-420092 9.866883e-01 0.006 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.866883e-01 0.006 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.866883e-01 0.006 0 0
Extracellular matrix organization R-HSA-1474244 9.867089e-01 0.006 0 0
ECM proteoglycans R-HSA-3000178 9.876408e-01 0.005 0 0
Cyclin D associated events in G1 R-HSA-69231 9.879022e-01 0.005 0 0
G1 Phase R-HSA-69236 9.879022e-01 0.005 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.879022e-01 0.005 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.879022e-01 0.005 0 0
Protein localization R-HSA-9609507 9.879521e-01 0.005 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.882353e-01 0.005 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.882353e-01 0.005 0 0
Peroxisomal protein import R-HSA-9033241 9.888871e-01 0.005 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.888871e-01 0.005 0 0
Cargo concentration in the ER R-HSA-5694530 9.896026e-01 0.005 0 0
Metabolism of polyamines R-HSA-351202 9.899196e-01 0.004 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.902377e-01 0.004 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.908593e-01 0.004 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.913025e-01 0.004 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.914764e-01 0.004 0 0
Mitochondrial protein import R-HSA-1268020 9.917142e-01 0.004 0 0
G-protein beta:gamma signalling R-HSA-397795 9.918791e-01 0.004 0 0
Peptide chain elongation R-HSA-156902 9.922989e-01 0.003 0 0
CS/DS degradation R-HSA-2024101 9.928231e-01 0.003 0 0
Heme degradation R-HSA-189483 9.928231e-01 0.003 0 0
Translation of Structural Proteins R-HSA-9694635 9.928402e-01 0.003 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.934708e-01 0.003 0 0
Interleukin-10 signaling R-HSA-6783783 9.934708e-01 0.003 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.936574e-01 0.003 0 0
eNOS activation R-HSA-203615 9.936574e-01 0.003 0 0
Signal amplification R-HSA-392518 9.936574e-01 0.003 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.941179e-01 0.003 0 0
Complex IV assembly R-HSA-9864848 9.943155e-01 0.002 0 0
The phototransduction cascade R-HSA-2514856 9.943155e-01 0.002 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.943948e-01 0.002 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.950235e-01 0.002 0 0
Triglyceride catabolism R-HSA-163560 9.950465e-01 0.002 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.950465e-01 0.002 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.954330e-01 0.002 0 0
NCAM1 interactions R-HSA-419037 9.956224e-01 0.002 0 0
Collagen chain trimerization R-HSA-8948216 9.956224e-01 0.002 0 0
Metabolism of folate and pterines R-HSA-196757 9.956224e-01 0.002 0 0
Mitochondrial protein degradation R-HSA-9837999 9.958304e-01 0.002 0 0
Collagen formation R-HSA-1474290 9.958304e-01 0.002 0 0
Purine salvage R-HSA-74217 9.961314e-01 0.002 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.961314e-01 0.002 0 0
Platelet homeostasis R-HSA-418346 9.962722e-01 0.002 0 0
Paracetamol ADME R-HSA-9753281 9.963273e-01 0.002 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.965109e-01 0.002 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.965765e-01 0.001 0 0
Pentose phosphate pathway R-HSA-71336 9.965813e-01 0.001 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.965813e-01 0.001 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.969475e-01 0.001 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.969788e-01 0.001 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.972663e-01 0.001 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.973302e-01 0.001 0 0
Maturation of spike protein R-HSA-9694548 9.973302e-01 0.001 0 0
Triglyceride metabolism R-HSA-8979227 9.976349e-01 0.001 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.977497e-01 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 9.980173e-01 0.001 0 0
Nucleotide salvage R-HSA-8956321 9.981042e-01 0.001 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.982608e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.983447e-01 0.001 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.983719e-01 0.001 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.985332e-01 0.001 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.985613e-01 0.001 0 0
Interferon alpha/beta signaling R-HSA-909733 9.985617e-01 0.001 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.986992e-01 0.001 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.987287e-01 0.001 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.988766e-01 0.000 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.989295e-01 0.000 0 0
Neddylation R-HSA-8951664 9.989861e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.990276e-01 0.000 0 0
Eukaryotic Translation Termination R-HSA-72764 9.990292e-01 0.000 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.991228e-01 0.000 0 0
Azathioprine ADME R-HSA-9748787 9.992249e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.992249e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.993151e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.993789e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.993883e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.994137e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.994160e-01 0.000 0 0
Immune System R-HSA-168256 9.994284e-01 0.000 1 0
Selenocysteine synthesis R-HSA-2408557 9.994626e-01 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 9.994652e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.995090e-01 0.000 0 0
Viral mRNA Translation R-HSA-192823 9.995595e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.995825e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.995838e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.996041e-01 0.000 0 0
Synthesis of PA R-HSA-1483166 9.996740e-01 0.000 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.996830e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.997180e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.997455e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.997658e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.998013e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.998013e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.998168e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.998281e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.998449e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.998630e-01 0.000 0 0
Ribosome-associated quality control R-HSA-9948299 9.998654e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.998671e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.998725e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.998987e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999135e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.999424e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.999424e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999424e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.999424e-01 0.000 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.999546e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999551e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999570e-01 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 9.999601e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.999603e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999636e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999649e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999674e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.999707e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999745e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999758e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.999786e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999797e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999833e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999837e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999844e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999844e-01 0.000 0 0
Translation R-HSA-72766 9.999860e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999865e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999885e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999950e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999951e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999952e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999955e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999957e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999965e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999971e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999977e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999980e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.999980e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999981e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999987e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999990e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999991e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999994e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999994e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999997e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999999e-01 0.000 1 0
O-linked glycosylation R-HSA-5173105 9.999999e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999999e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999999e-01 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 1 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
G alpha (i) signalling events R-HSA-418594 1.000000e+00 0.000 1 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 1 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 1 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 0 0
Cell Cycle, Mitotic R-HSA-69278 1.110223e-16 15.955 0 0
M Phase R-HSA-68886 1.187939e-14 13.925 0 0
Metabolism of RNA R-HSA-8953854 2.120526e-14 13.674 0 0
Cell Cycle Checkpoints R-HSA-69620 3.209655e-13 12.494 0 0
Apoptotic execution phase R-HSA-75153 9.934686e-11 10.003 0 0
G2/M Checkpoints R-HSA-69481 2.986603e-10 9.525 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.398238e-09 8.854 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.780236e-09 8.750 0 0
Cell-Cell communication R-HSA-1500931 2.388075e-09 8.622 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 5.019159e-09 8.299 0 0
G2/M DNA damage checkpoint R-HSA-69473 6.103027e-09 8.214 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 7.181626e-09 8.144 0 0
Mitotic Prometaphase R-HSA-68877 8.012335e-09 8.096 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 9.549047e-09 8.020 0 0
Apoptosis R-HSA-109581 9.492316e-09 8.023 0 0
Cellular responses to stimuli R-HSA-8953897 1.240666e-08 7.906 1 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.491058e-08 7.827 0 0
DNA Double Strand Break Response R-HSA-5693606 1.557846e-08 7.807 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.784715e-08 7.555 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.817852e-08 7.550 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.272801e-08 7.369 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 6.321692e-08 7.199 0 0
Mitotic Prophase R-HSA-68875 6.455491e-08 7.190 0 0
Eukaryotic Translation Initiation R-HSA-72613 9.595641e-08 7.018 0 0
Cap-dependent Translation Initiation R-HSA-72737 9.595641e-08 7.018 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.264272e-07 6.898 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.354867e-07 6.868 0 0
Cellular responses to stress R-HSA-2262752 1.320702e-07 6.879 1 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.483193e-07 6.829 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.580077e-07 6.588 0 0
Processing of DNA double-strand break ends R-HSA-5693607 4.032832e-07 6.394 0 0
Homology Directed Repair R-HSA-5693538 3.955978e-07 6.403 0 0
Mitotic Anaphase R-HSA-68882 4.554915e-07 6.342 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 5.118667e-07 6.291 0 0
rRNA processing R-HSA-72312 5.362961e-07 6.271 0 0
Separation of Sister Chromatids R-HSA-2467813 6.361750e-07 6.196 0 0
HDACs deacetylate histones R-HSA-3214815 6.706232e-07 6.174 0 0
Nucleosome assembly R-HSA-774815 7.860810e-07 6.105 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 7.860810e-07 6.105 0 0
Axon guidance R-HSA-422475 8.289915e-07 6.081 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 8.692630e-07 6.061 0 0
mRNA Splicing - Major Pathway R-HSA-72163 9.082204e-07 6.042 0 0
Nervous system development R-HSA-9675108 1.044644e-06 5.981 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.213439e-06 5.916 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.316682e-06 5.881 0 0
Cell junction organization R-HSA-446728 1.311464e-06 5.882 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.540303e-06 5.812 0 0
Chromatin organization R-HSA-4839726 1.501549e-06 5.823 0 0
Programmed Cell Death R-HSA-5357801 1.586281e-06 5.800 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.840545e-06 5.735 0 0
G2/M Transition R-HSA-69275 1.946035e-06 5.711 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.974010e-06 5.705 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.183139e-06 5.661 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.286070e-06 5.641 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.286070e-06 5.641 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.463072e-06 5.609 0 0
mRNA Splicing R-HSA-72172 3.227603e-06 5.491 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.599243e-06 5.337 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 4.959062e-06 5.305 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 4.838403e-06 5.315 1 1
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 5.251182e-06 5.280 0 0
Meiotic synapsis R-HSA-1221632 5.787505e-06 5.238 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 5.787505e-06 5.238 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 6.420977e-06 5.192 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 7.249367e-06 5.140 0 0
RNA Polymerase I Transcription R-HSA-73864 7.544227e-06 5.122 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 7.725833e-06 5.112 0 0
Formation of a pool of free 40S subunits R-HSA-72689 8.916170e-06 5.050 0 0
Influenza Infection R-HSA-168255 1.071653e-05 4.970 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.171332e-05 4.931 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.240661e-05 4.906 0 0
Signaling by ROBO receptors R-HSA-376176 1.279775e-05 4.893 0 0
Protein ubiquitination R-HSA-8852135 1.347140e-05 4.871 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.499999e-05 4.824 0 0
Chromatin modifying enzymes R-HSA-3247509 1.484325e-05 4.828 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.529281e-05 4.816 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.671848e-05 4.777 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.611017e-05 4.793 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.671848e-05 4.777 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.800741e-05 4.745 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.800741e-05 4.745 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.088868e-05 4.680 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.063407e-05 4.685 0 0
Nephrin family interactions R-HSA-373753 2.621790e-05 4.581 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.867009e-05 4.543 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.867009e-05 4.543 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 2.873379e-05 4.542 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.925532e-05 4.534 0 0
Adherens junctions interactions R-HSA-418990 2.928346e-05 4.533 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 3.173308e-05 4.498 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 3.119127e-05 4.506 1 0
Ribosomal scanning and start codon recognition R-HSA-72702 3.756582e-05 4.425 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 3.983409e-05 4.400 0 0
Centrosome maturation R-HSA-380287 4.042253e-05 4.393 0 0
Interleukin-12 family signaling R-HSA-447115 4.060185e-05 4.391 0 0
Peptide chain elongation R-HSA-156902 4.735019e-05 4.325 0 0
Nuclear Envelope Breakdown R-HSA-2980766 4.566740e-05 4.340 0 0
Interleukin-12 signaling R-HSA-9020591 4.777868e-05 4.321 0 0
Mitotic Spindle Checkpoint R-HSA-69618 5.130137e-05 4.290 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 5.743580e-05 4.241 0 0
Cellular Senescence R-HSA-2559583 5.784128e-05 4.238 0 0
Chaperone Mediated Autophagy R-HSA-9613829 6.636330e-05 4.178 0 0
Smooth Muscle Contraction R-HSA-445355 6.795705e-05 4.168 0 0
Packaging Of Telomere Ends R-HSA-171306 7.052380e-05 4.152 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 7.052380e-05 4.152 0 0
AURKA Activation by TPX2 R-HSA-8854518 7.621147e-05 4.118 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 7.781403e-05 4.109 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 7.503365e-05 4.125 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 7.621147e-05 4.118 0 0
SARS-CoV-2-host interactions R-HSA-9705683 7.279395e-05 4.138 0 0
Translation initiation complex formation R-HSA-72649 8.242060e-05 4.084 0 0
Amplification of signal from the kinetochores R-HSA-141424 8.220576e-05 4.085 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 8.220576e-05 4.085 0 0
Cell-extracellular matrix interactions R-HSA-446353 8.030920e-05 4.095 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 8.004144e-05 4.097 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 8.496618e-05 4.071 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 8.030920e-05 4.095 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 8.030920e-05 4.095 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 8.768393e-05 4.057 0 0
S Phase R-HSA-69242 9.355595e-05 4.029 0 0
Striated Muscle Contraction R-HSA-390522 1.087620e-04 3.964 0 0
DNA methylation R-HSA-5334118 1.213174e-04 3.916 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.354480e-04 3.868 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.354480e-04 3.868 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.274096e-04 3.895 0 0
Signal Transduction R-HSA-162582 1.327517e-04 3.877 1 0
Cell-cell junction organization R-HSA-421270 1.308671e-04 3.883 0 0
Membrane Trafficking R-HSA-199991 1.359497e-04 3.867 0 0
Muscle contraction R-HSA-397014 1.428568e-04 3.845 1 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.474744e-04 3.831 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.567624e-04 3.805 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.714687e-04 3.766 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.714687e-04 3.766 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.703771e-04 3.769 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.686580e-04 3.773 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.645837e-04 3.784 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.709118e-04 3.767 0 0
DNA Replication R-HSA-69306 1.578670e-04 3.802 0 0
Cellular response to heat stress R-HSA-3371556 1.798210e-04 3.745 1 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.834443e-04 3.736 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.889572e-04 3.724 1 1
Meiosis R-HSA-1500620 1.898755e-04 3.722 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 2.063390e-04 3.685 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.241178e-04 3.650 1 1
CaM pathway R-HSA-111997 2.176663e-04 3.662 1 0
Calmodulin induced events R-HSA-111933 2.176663e-04 3.662 1 0
Regulation of TP53 Degradation R-HSA-6804757 2.176663e-04 3.662 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.289130e-04 3.640 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.188331e-04 3.660 0 0
Signaling by Hippo R-HSA-2028269 2.363784e-04 3.626 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 2.547414e-04 3.594 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 2.703742e-04 3.568 0 0
Ca-dependent events R-HSA-111996 2.738634e-04 3.562 1 0
Interaction between L1 and Ankyrins R-HSA-445095 2.899968e-04 3.538 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 3.012141e-04 3.521 0 0
Ribosome-associated quality control R-HSA-9948299 3.133890e-04 3.504 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.293726e-04 3.482 0 0
Signaling by VEGF R-HSA-194138 3.141936e-04 3.503 0 0
ESR-mediated signaling R-HSA-8939211 2.968957e-04 3.527 0 0
Regulation of TP53 Activity R-HSA-5633007 3.139337e-04 3.503 0 0
Glycolysis R-HSA-70171 3.226349e-04 3.491 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 3.054139e-04 3.515 0 0
Diseases of programmed cell death R-HSA-9645723 3.285402e-04 3.483 0 0
Defective pyroptosis R-HSA-9710421 3.327972e-04 3.478 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 3.557548e-04 3.449 0 0
Epigenetic regulation of gene expression R-HSA-212165 3.572819e-04 3.447 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.621202e-04 3.441 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 3.901220e-04 3.409 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 4.090336e-04 3.388 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.090336e-04 3.388 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.090336e-04 3.388 0 0
Chromosome Maintenance R-HSA-73886 4.094864e-04 3.388 0 0
Eukaryotic Translation Termination R-HSA-72764 4.206654e-04 3.376 0 0
DNA Repair R-HSA-73894 4.246228e-04 3.372 0 0
Regulation of CDH1 Function R-HSA-9764561 4.257264e-04 3.371 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 4.290145e-04 3.368 0 0
DAG and IP3 signaling R-HSA-1489509 4.837364e-04 3.315 1 0
NoRC negatively regulates rRNA expression R-HSA-427413 4.747642e-04 3.324 0 0
Meiotic recombination R-HSA-912446 4.580198e-04 3.339 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.842279e-04 3.315 0 0
Oncogenic MAPK signaling R-HSA-6802957 4.878531e-04 3.312 1 0
HIV Life Cycle R-HSA-162587 4.903287e-04 3.310 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 4.964994e-04 3.304 0 0
Aggrephagy R-HSA-9646399 4.984568e-04 3.302 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 4.984568e-04 3.302 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 5.334966e-04 3.273 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 5.426646e-04 3.265 0 0
Signaling downstream of RAS mutants R-HSA-9649948 5.788498e-04 3.237 1 1
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 5.788498e-04 3.237 1 1
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 5.788498e-04 3.237 1 1
Signaling by RAS mutants R-HSA-6802949 5.788498e-04 3.237 1 0
Metabolism of non-coding RNA R-HSA-194441 5.858448e-04 3.232 0 0
snRNP Assembly R-HSA-191859 5.858448e-04 3.232 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 5.880470e-04 3.231 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 5.943730e-04 3.226 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 5.943730e-04 3.226 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 6.038974e-04 3.219 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 6.354159e-04 3.197 0 0
Signaling by ERBB2 R-HSA-1227986 6.835810e-04 3.165 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 7.755726e-04 3.110 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 7.729829e-04 3.112 0 0
PLC beta mediated events R-HSA-112043 7.949006e-04 3.100 1 0
Amyloid fiber formation R-HSA-977225 7.245427e-04 3.140 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 8.155891e-04 3.089 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 8.155891e-04 3.089 0 0
Signaling by ALK in cancer R-HSA-9700206 8.155891e-04 3.089 0 0
Gene Silencing by RNA R-HSA-211000 8.155891e-04 3.089 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 8.242194e-04 3.084 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 9.078110e-04 3.042 0 0
Cleavage of the damaged purine R-HSA-110331 9.078110e-04 3.042 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 9.542777e-04 3.020 0 0
HCMV Early Events R-HSA-9609690 9.647831e-04 3.016 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.002720e-03 2.999 1 1
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.002720e-03 2.999 0 0
Depurination R-HSA-73927 1.096102e-03 2.960 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.121355e-03 2.950 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.366720e-03 2.864 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.366720e-03 2.864 0 0
Josephin domain DUBs R-HSA-5689877 1.390758e-03 2.857 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.390758e-03 2.857 1 1
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.390758e-03 2.857 0 0
EPH-Ephrin signaling R-HSA-2682334 1.458933e-03 2.836 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.558184e-03 2.807 0 0
Dual Incision in GG-NER R-HSA-5696400 1.654473e-03 2.781 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.711144e-03 2.767 0 0
Post NMDA receptor activation events R-HSA-438064 1.704492e-03 2.768 1 0
Nuclear import of Rev protein R-HSA-180746 1.654473e-03 2.781 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.570479e-03 2.804 0 0
HATs acetylate histones R-HSA-3214847 1.551262e-03 2.809 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.570479e-03 2.804 0 0
Viral Infection Pathways R-HSA-9824446 1.654845e-03 2.781 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.627030e-03 2.789 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.743905e-03 2.758 0 0
G-protein mediated events R-HSA-112040 1.839015e-03 2.735 1 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.864546e-03 2.729 0 0
Rap1 signalling R-HSA-392517 1.877301e-03 2.726 0 0
Signaling by WNT R-HSA-195721 1.880669e-03 2.726 0 0
Selenocysteine synthesis R-HSA-2408557 1.916269e-03 2.718 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.989889e-03 2.701 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.047593e-03 2.689 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.047593e-03 2.689 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.061087e-03 2.686 0 0
Activation of BH3-only proteins R-HSA-114452 2.061087e-03 2.686 0 0
Viral mRNA Translation R-HSA-192823 2.351665e-03 2.629 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.388621e-03 2.622 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.502435e-03 2.602 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.502854e-03 2.602 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.502854e-03 2.602 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 2.588482e-03 2.587 0 0
Depyrimidination R-HSA-73928 2.588482e-03 2.587 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.598948e-03 2.585 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.655183e-03 2.576 1 0
Glucose metabolism R-HSA-70326 2.716104e-03 2.566 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 2.820229e-03 2.550 0 0
HIV Infection R-HSA-162906 2.848904e-03 2.545 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 3.045869e-03 2.516 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 3.045869e-03 2.516 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 3.666032e-03 2.436 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.810185e-03 2.419 1 1
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.810185e-03 2.419 1 1
IPs transport between nucleus and cytosol R-HSA-1855170 3.612994e-03 2.442 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.422327e-03 2.466 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 3.529378e-03 2.452 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.845560e-03 2.415 0 0
Cilium Assembly R-HSA-5617833 3.847326e-03 2.415 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 3.340137e-03 2.476 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.612994e-03 2.442 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 3.666032e-03 2.436 0 0
Pervasive developmental disorders R-HSA-9005895 3.851484e-03 2.414 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 3.851484e-03 2.414 0 0
Disorders of Nervous System Development R-HSA-9697154 3.851484e-03 2.414 0 0
mRNA 3'-end processing R-HSA-72187 4.134251e-03 2.384 0 0
Orc1 removal from chromatin R-HSA-68949 4.134251e-03 2.384 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 4.138952e-03 2.383 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 4.138952e-03 2.383 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 4.298114e-03 2.367 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 4.529495e-03 2.344 1 0
Phase 0 - rapid depolarisation R-HSA-5576892 4.589959e-03 2.338 1 1
Kinesins R-HSA-983189 4.643643e-03 2.333 0 0
Host Interactions of HIV factors R-HSA-162909 5.009027e-03 2.300 0 0
L1CAM interactions R-HSA-373760 5.028211e-03 2.299 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 5.056401e-03 2.296 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 5.138546e-03 2.289 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 5.138546e-03 2.289 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 5.138546e-03 2.289 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 5.138546e-03 2.289 0 0
Base Excision Repair R-HSA-73884 5.251486e-03 2.280 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 5.262291e-03 2.279 0 0
Late endosomal microautophagy R-HSA-9615710 5.507233e-03 2.259 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 5.604638e-03 2.251 0 0
PKA activation R-HSA-163615 5.733390e-03 2.242 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 5.733390e-03 2.242 0 0
G1/S Transition R-HSA-69206 5.901771e-03 2.229 0 0
Telomere Maintenance R-HSA-157579 5.905539e-03 2.229 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 6.187291e-03 2.208 1 1
Nucleotide Excision Repair R-HSA-5696398 6.518028e-03 2.186 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 6.577511e-03 2.182 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 6.577511e-03 2.182 0 0
Maturation of protein E R-HSA-9694493 6.577511e-03 2.182 0 0
Maturation of protein E R-HSA-9683683 6.577511e-03 2.182 0 0
Semaphorin interactions R-HSA-373755 6.658938e-03 2.177 0 0
NRIF signals cell death from the nucleus R-HSA-205043 6.715656e-03 2.173 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 6.715656e-03 2.173 0 0
Ub-specific processing proteases R-HSA-5689880 6.816819e-03 2.166 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 7.296329e-03 2.137 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 7.153601e-03 2.145 0 0
Long-term potentiation R-HSA-9620244 8.430737e-03 2.074 1 1
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 7.296329e-03 2.137 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 7.008630e-03 2.154 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 8.436109e-03 2.074 0 0
Translesion synthesis by REV1 R-HSA-110312 8.616896e-03 2.065 0 0
Trafficking of AMPA receptors R-HSA-399719 7.760901e-03 2.110 1 1
Late Phase of HIV Life Cycle R-HSA-162599 7.710246e-03 2.113 0 0
Synthesis of DNA R-HSA-69239 7.751747e-03 2.111 0 0
Regulation of signaling by CBL R-HSA-912631 7.153601e-03 2.145 0 0
Cellular response to starvation R-HSA-9711097 7.278676e-03 2.138 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 7.874723e-03 2.104 0 0
Hedgehog 'off' state R-HSA-5610787 7.756761e-03 2.110 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 7.874723e-03 2.104 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 7.093729e-03 2.149 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 7.740235e-03 2.111 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 8.745485e-03 2.058 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 8.818893e-03 2.055 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 8.818893e-03 2.055 0 0
Deubiquitination R-HSA-5688426 8.853828e-03 2.053 0 0
Reproduction R-HSA-1474165 9.397451e-03 2.027 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 9.822711e-03 2.008 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 9.822711e-03 2.008 0 0
Death Receptor Signaling R-HSA-73887 9.893556e-03 2.005 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.005847e-02 1.997 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.005847e-02 1.997 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.056413e-02 1.976 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.065692e-02 1.972 1 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.071524e-02 1.970 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.075214e-02 1.969 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.080949e-02 1.966 0 0
Translesion synthesis by POLI R-HSA-5656121 1.087565e-02 1.964 0 0
Regulation of BACH1 activity R-HSA-9708530 1.087565e-02 1.964 0 0
HCMV Infection R-HSA-9609646 1.090839e-02 1.962 0 0
Opioid Signalling R-HSA-111885 1.092729e-02 1.961 1 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.114543e-02 1.953 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.120194e-02 1.951 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.143945e-02 1.942 1 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.161512e-02 1.935 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 1.161512e-02 1.935 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 1.190845e-02 1.924 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.190845e-02 1.924 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.229545e-02 1.910 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.238615e-02 1.907 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 1.289249e-02 1.890 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.289249e-02 1.890 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 1.297583e-02 1.887 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.297583e-02 1.887 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.303221e-02 1.885 0 0
Translesion synthesis by POLK R-HSA-5655862 1.352409e-02 1.869 0 0
Disorders of Developmental Biology R-HSA-9675151 1.352409e-02 1.869 0 0
Translation R-HSA-72766 1.352496e-02 1.869 0 0
Recycling pathway of L1 R-HSA-437239 1.366969e-02 1.864 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.367882e-02 1.864 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.367882e-02 1.864 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.390228e-02 1.857 0 0
Regulation of PTEN localization R-HSA-8948747 1.394534e-02 1.856 0 0
Interferon Signaling R-HSA-913531 1.406245e-02 1.852 1 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.408780e-02 1.851 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.413000e-02 1.850 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.413000e-02 1.850 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.430482e-02 1.845 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.457775e-02 1.836 0 0
SARS-CoV Infections R-HSA-9679506 1.460120e-02 1.836 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.468732e-02 1.833 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.468732e-02 1.833 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.468732e-02 1.833 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.468732e-02 1.833 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.468732e-02 1.833 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.468732e-02 1.833 0 0
mTORC1-mediated signalling R-HSA-166208 1.551186e-02 1.809 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 1.551186e-02 1.809 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.553204e-02 1.809 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.553204e-02 1.809 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.605108e-02 1.794 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 1.605108e-02 1.794 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 1.605108e-02 1.794 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.625863e-02 1.789 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.625863e-02 1.789 0 0
Signaling by EGFR R-HSA-177929 1.625863e-02 1.789 0 0
VLDLR internalisation and degradation R-HSA-8866427 1.655225e-02 1.781 0 0
IRAK1 recruits IKK complex R-HSA-937039 1.655225e-02 1.781 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 1.655225e-02 1.781 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.655225e-02 1.781 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.796676e-02 1.746 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.903388e-02 1.720 1 1
PKA activation in glucagon signalling R-HSA-164378 2.010997e-02 1.697 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.838121e-02 1.736 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.137065e-02 1.670 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 2.395958e-02 1.621 0 0
Dual incision in TC-NER R-HSA-6782135 2.005378e-02 1.698 0 0
Translesion Synthesis by POLH R-HSA-110320 2.410176e-02 1.618 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.878132e-02 1.726 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 1.903388e-02 1.720 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 1.903388e-02 1.720 0 0
Vesicle-mediated transport R-HSA-5653656 1.900457e-02 1.721 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.447161e-02 1.611 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.903388e-02 1.720 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.146486e-02 1.668 0 0
FLT3 signaling in disease R-HSA-9682385 1.878132e-02 1.726 0 0
Modulation by Mtb of host immune system R-HSA-9637628 1.903388e-02 1.720 0 0
SARS-CoV-2 Infection R-HSA-9694516 2.277054e-02 1.643 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.505378e-02 1.601 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.513739e-02 1.600 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.513739e-02 1.600 0 0
Cellular response to mitochondrial stress R-HSA-9840373 2.513739e-02 1.600 0 0
Unwinding of DNA R-HSA-176974 2.513739e-02 1.600 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.519827e-02 1.599 0 0
Signaling by NOTCH R-HSA-157118 2.562007e-02 1.591 0 0
IRE1alpha activates chaperones R-HSA-381070 2.567436e-02 1.591 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 2.570308e-02 1.590 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.580116e-02 1.588 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 2.580116e-02 1.588 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 2.580116e-02 1.588 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.617570e-02 1.582 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.672305e-02 1.573 0 0
IRS activation R-HSA-74713 2.692545e-02 1.570 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.692545e-02 1.570 0 0
Cytokine Signaling in Immune system R-HSA-1280215 2.784895e-02 1.555 1 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.856663e-02 1.544 1 0
Negative regulation of MET activity R-HSA-6807004 2.859128e-02 1.544 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 2.865462e-02 1.543 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.865462e-02 1.543 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.865462e-02 1.543 0 0
Metalloprotease DUBs R-HSA-5689901 2.918169e-02 1.535 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.942370e-02 1.531 0 0
tRNA processing in the nucleus R-HSA-6784531 2.956406e-02 1.529 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 3.066346e-02 1.513 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.075050e-02 1.512 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.075050e-02 1.512 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.113908e-02 1.507 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.113908e-02 1.507 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 3.145504e-02 1.502 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 3.145504e-02 1.502 0 0
Spry regulation of FGF signaling R-HSA-1295596 3.145504e-02 1.502 0 0
p75NTR signals via NF-kB R-HSA-193639 3.145504e-02 1.502 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 3.183901e-02 1.497 0 0
2-LTR circle formation R-HSA-164843 3.229386e-02 1.491 0 0
Pexophagy R-HSA-9664873 3.229386e-02 1.491 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.356954e-02 1.474 0 0
Early Phase of HIV Life Cycle R-HSA-162594 3.359870e-02 1.474 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 3.359870e-02 1.474 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 3.411356e-02 1.467 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 3.464061e-02 1.460 0 0
TNF signaling R-HSA-75893 3.555874e-02 1.449 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.555874e-02 1.449 0 0
Selective autophagy R-HSA-9663891 3.578204e-02 1.446 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 3.658137e-02 1.437 0 0
RAF activation R-HSA-5673000 3.658137e-02 1.437 1 1
Calnexin/calreticulin cycle R-HSA-901042 3.658137e-02 1.437 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.763585e-02 1.424 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 3.763585e-02 1.424 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 3.782772e-02 1.422 0 0
Negative regulation of FLT3 R-HSA-9706369 3.782772e-02 1.422 0 0
MAP2K and MAPK activation R-HSA-5674135 3.823158e-02 1.418 0 0
MITF-M-dependent gene expression R-HSA-9856651 3.834970e-02 1.416 0 0
Degradation of CDH1 R-HSA-9766229 3.893766e-02 1.410 0 0
Assembly Of The HIV Virion R-HSA-175474 3.914095e-02 1.407 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 3.914095e-02 1.407 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.914095e-02 1.407 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 5.218782e-02 1.282 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 5.218782e-02 1.282 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 5.218782e-02 1.282 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 5.218782e-02 1.282 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 5.218782e-02 1.282 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 5.218782e-02 1.282 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 5.218782e-02 1.282 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 5.218782e-02 1.282 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 5.218782e-02 1.282 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 5.218782e-02 1.282 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 5.218782e-02 1.282 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 5.218782e-02 1.282 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 5.218782e-02 1.282 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 4.361126e-02 1.360 0 0
Termination of translesion DNA synthesis R-HSA-5656169 4.361126e-02 1.360 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 4.361126e-02 1.360 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 5.540921e-02 1.256 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 5.122967e-02 1.290 0 0
Regulation of RAS by GAPs R-HSA-5658442 4.286626e-02 1.368 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.928662e-02 1.307 0 0
HSF1-dependent transactivation R-HSA-3371571 4.705626e-02 1.327 1 1
Integration of provirus R-HSA-162592 4.983791e-02 1.302 0 0
Degradation of DVL R-HSA-4641258 5.122967e-02 1.290 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 5.696460e-02 1.244 0 0
DARPP-32 events R-HSA-180024 4.361126e-02 1.360 0 0
Budding and maturation of HIV virion R-HSA-162588 5.540921e-02 1.256 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 4.598515e-02 1.337 0 0
PCP/CE pathway R-HSA-4086400 5.544043e-02 1.256 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.245452e-02 1.372 0 0
Fanconi Anemia Pathway R-HSA-6783310 5.696460e-02 1.244 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.555777e-02 1.341 0 0
EPHB-mediated forward signaling R-HSA-3928662 5.181501e-02 1.286 0 0
MTOR signalling R-HSA-165159 4.245452e-02 1.372 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.497833e-02 1.260 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 5.696460e-02 1.244 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 5.696460e-02 1.244 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.971427e-02 1.304 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 4.493537e-02 1.347 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 5.614122e-02 1.251 0 0
Co-inhibition by PD-1 R-HSA-389948 4.971427e-02 1.304 0 0
HCMV Late Events R-HSA-9610379 5.515675e-02 1.258 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.540921e-02 1.256 0 0
Signaling by Hedgehog R-HSA-5358351 5.030854e-02 1.298 0 0
RET signaling R-HSA-8853659 4.598515e-02 1.337 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 4.935772e-02 1.307 0 0
PTEN Regulation R-HSA-6807070 5.306447e-02 1.275 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 4.959530e-02 1.305 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 5.909511e-02 1.228 0 0
Neurodegenerative Diseases R-HSA-8863678 5.909511e-02 1.228 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 5.696460e-02 1.244 0 0
NF-kB is activated and signals survival R-HSA-209560 4.983791e-02 1.302 0 0
Signaling by Interleukins R-HSA-449147 4.895602e-02 1.310 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 4.245452e-02 1.372 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 5.921453e-02 1.228 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.957148e-02 1.225 0 0
MAPK family signaling cascades R-HSA-5683057 6.010544e-02 1.221 1 0
AKT phosphorylates targets in the cytosol R-HSA-198323 6.022471e-02 1.220 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 6.022471e-02 1.220 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 6.022471e-02 1.220 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 6.022471e-02 1.220 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 6.124769e-02 1.213 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 6.124769e-02 1.213 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 6.138760e-02 1.212 0 0
GAB1 signalosome R-HSA-180292 6.138760e-02 1.212 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 6.138760e-02 1.212 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 6.138760e-02 1.212 0 0
Potential therapeutics for SARS R-HSA-9679191 6.143008e-02 1.212 0 0
DNA strand elongation R-HSA-69190 6.198456e-02 1.208 0 0
G0 and Early G1 R-HSA-1538133 6.198456e-02 1.208 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 6.243349e-02 1.205 0 0
Stabilization of p53 R-HSA-69541 6.283569e-02 1.202 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 6.283569e-02 1.202 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 6.382015e-02 1.195 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 6.452204e-02 1.190 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 6.452204e-02 1.190 0 0
Platelet degranulation R-HSA-114608 6.613010e-02 1.180 0 0
Signaling by NOTCH3 R-HSA-9012852 6.653279e-02 1.177 0 0
Interleukin-7 signaling R-HSA-1266695 6.687776e-02 1.175 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 6.901606e-02 1.161 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 6.920568e-02 1.160 0 0
Glycogen metabolism R-HSA-8982491 6.920568e-02 1.160 0 0
Activation of HOX genes during differentiation R-HSA-5619507 7.029847e-02 1.153 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 7.029847e-02 1.153 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 7.073240e-02 1.150 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 7.210042e-02 1.142 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 7.210042e-02 1.142 0 0
Signaling by Nuclear Receptors R-HSA-9006931 7.329990e-02 1.135 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 7.436415e-02 1.129 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.522845e-02 1.124 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 7.595690e-02 1.119 0 0
FLT3 Signaling R-HSA-9607240 7.595690e-02 1.119 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 7.650492e-02 1.116 0 0
Vpu mediated degradation of CD4 R-HSA-180534 7.650492e-02 1.116 0 0
Selenoamino acid metabolism R-HSA-2408522 7.663714e-02 1.116 0 0
Signaling by NOTCH4 R-HSA-9013694 7.670160e-02 1.115 0 0
Signaling by ERBB4 R-HSA-1236394 7.670160e-02 1.115 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 7.690998e-02 1.114 0 0
Type I hemidesmosome assembly R-HSA-446107 8.050144e-02 1.094 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 8.050144e-02 1.094 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 8.050144e-02 1.094 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 8.081314e-02 1.093 0 0
Glycogen synthesis R-HSA-3322077 8.081314e-02 1.093 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 8.199209e-02 1.086 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 8.204094e-02 1.086 0 0
RAF/MAP kinase cascade R-HSA-5673001 8.410844e-02 1.075 1 1
CD28 dependent PI3K/Akt signaling R-HSA-389357 8.414354e-02 1.075 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 8.414354e-02 1.075 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.445026e-02 1.073 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.445026e-02 1.073 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.445026e-02 1.073 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 8.445026e-02 1.073 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 8.529936e-02 1.069 1 0
SARS-CoV-1 Infection R-HSA-9678108 8.569737e-02 1.067 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 8.702042e-02 1.060 0 0
Organelle biogenesis and maintenance R-HSA-1852241 8.860669e-02 1.053 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.060401e-02 1.043 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.161548e-02 1.038 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 9.284905e-02 1.032 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.284905e-02 1.032 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.284905e-02 1.032 0 0
Regulation of Apoptosis R-HSA-169911 9.284905e-02 1.032 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.465580e-02 1.024 0 0
DCC mediated attractive signaling R-HSA-418885 9.757368e-02 1.011 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 9.757368e-02 1.011 0 0
Protein methylation R-HSA-8876725 9.757368e-02 1.011 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 9.757368e-02 1.011 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 9.757368e-02 1.011 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 9.800368e-02 1.009 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 9.800368e-02 1.009 0 0
Gap junction degradation R-HSA-190873 9.800368e-02 1.009 0 0
ALK mutants bind TKIs R-HSA-9700645 9.800368e-02 1.009 0 0
Gene expression (Transcription) R-HSA-74160 9.855545e-02 1.006 1 0
KEAP1-NFE2L2 pathway R-HSA-9755511 9.898593e-02 1.004 0 0
HSF1 activation R-HSA-3371511 1.016963e-01 0.993 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.031200e-01 0.987 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.036365e-01 0.984 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.045077e-01 0.981 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.045077e-01 0.981 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 1.045077e-01 0.981 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.052004e-01 0.978 1 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.053264e-01 0.977 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.054473e-01 0.977 0 0
Sensory processing of sound R-HSA-9659379 1.056784e-01 0.976 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 1.067646e-01 0.972 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.067646e-01 0.972 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.094296e-01 0.961 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.098244e-01 0.959 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.098244e-01 0.959 0 0
Degradation of AXIN R-HSA-4641257 1.109849e-01 0.955 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.109849e-01 0.955 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.119505e-01 0.951 0 0
Signaling by MET R-HSA-6806834 1.121567e-01 0.950 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.124026e-01 0.949 0 0
Activation of the pre-replicative complex R-HSA-68962 1.141915e-01 0.942 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 1.153027e-01 0.938 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 1.154025e-01 0.938 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.166748e-01 0.933 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.168851e-01 0.932 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.168851e-01 0.932 0 0
PI3K/AKT activation R-HSA-198203 1.168851e-01 0.932 0 0
Signal attenuation R-HSA-74749 1.168851e-01 0.932 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.190539e-01 0.924 0 0
Signaling by PTK6 R-HSA-8848021 1.190539e-01 0.924 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.190539e-01 0.924 0 0
Autophagy R-HSA-9612973 1.218924e-01 0.914 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.228740e-01 0.911 0 0
Regulation of pyruvate metabolism R-HSA-9861718 1.244039e-01 0.905 0 0
EGFR downregulation R-HSA-182971 1.252658e-01 0.902 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.252658e-01 0.902 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.272030e-01 0.896 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.272030e-01 0.896 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 1.272030e-01 0.896 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 1.272030e-01 0.896 0 0
Growth hormone receptor signaling R-HSA-982772 1.281354e-01 0.892 0 0
Syndecan interactions R-HSA-3000170 1.281354e-01 0.892 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.312373e-01 0.882 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 1.337613e-01 0.874 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.342426e-01 0.872 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 1.342941e-01 0.872 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 1.342941e-01 0.872 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 1.342941e-01 0.872 0 0
Ion homeostasis R-HSA-5578775 1.349535e-01 0.870 1 1
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 1.664730e-01 0.779 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.664730e-01 0.779 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.664730e-01 0.779 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 1.664730e-01 0.779 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 1.664730e-01 0.779 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 2.390155e-01 0.622 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.390155e-01 0.622 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 2.390155e-01 0.622 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 2.390155e-01 0.622 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 2.390155e-01 0.622 0 0
IKBKB deficiency causes SCID R-HSA-5602636 2.390155e-01 0.622 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 2.390155e-01 0.622 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.390155e-01 0.622 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.390155e-01 0.622 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 2.390155e-01 0.622 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.656799e-01 0.781 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.656799e-01 0.781 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.981616e-01 0.703 0 0
Signaling by LTK in cancer R-HSA-9842640 1.981616e-01 0.703 0 0
Erythropoietin activates STAT5 R-HSA-9027283 1.981616e-01 0.703 0 0
Autointegration results in viral DNA circles R-HSA-177539 1.981616e-01 0.703 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 1.981616e-01 0.703 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.581775e-01 0.801 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.313111e-01 0.636 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 2.313111e-01 0.636 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.313111e-01 0.636 0 0
Recycling of eIF2:GDP R-HSA-72731 2.313111e-01 0.636 0 0
SOS-mediated signalling R-HSA-112412 2.313111e-01 0.636 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.802792e-01 0.744 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.432691e-01 0.844 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.432691e-01 0.844 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 1.432691e-01 0.844 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 2.647667e-01 0.577 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 2.647667e-01 0.577 0 0
Formation of annular gap junctions R-HSA-196025 2.647667e-01 0.577 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.031480e-01 0.692 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 1.600827e-01 0.796 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 1.600827e-01 0.796 0 0
Deadenylation of mRNA R-HSA-429947 1.415862e-01 0.849 0 0
Erythropoietin activates RAS R-HSA-9027284 2.506049e-01 0.601 0 0
GPER1 signaling R-HSA-9634597 1.434658e-01 0.843 0 0
Signaling by Erythropoietin R-HSA-9006335 2.168057e-01 0.664 0 0
FGFR2 alternative splicing R-HSA-6803529 2.528825e-01 0.597 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 2.528825e-01 0.597 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 2.331542e-01 0.632 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 2.726842e-01 0.564 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 2.498361e-01 0.602 0 0
Post-translational protein phosphorylation R-HSA-8957275 2.005658e-01 0.698 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.719028e-01 0.566 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 2.541669e-01 0.595 0 0
G-protein beta:gamma signalling R-HSA-397795 1.488976e-01 0.827 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.523491e-01 0.817 0 0
Integrin signaling R-HSA-354192 1.488976e-01 0.827 0 0
DNA Damage Bypass R-HSA-73893 1.535073e-01 0.814 0 0
UCH proteinases R-HSA-5689603 1.501552e-01 0.823 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 2.600757e-01 0.585 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.457922e-01 0.836 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.457922e-01 0.836 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.457922e-01 0.836 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.794144e-01 0.746 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 2.528825e-01 0.597 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 1.656799e-01 0.781 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 2.528825e-01 0.597 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.627938e-01 0.788 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 1.802792e-01 0.744 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 2.726842e-01 0.564 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 2.124374e-01 0.673 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 1.701999e-01 0.769 0 0
Ephrin signaling R-HSA-3928664 1.600827e-01 0.796 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.656799e-01 0.781 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.506049e-01 0.601 0 0
Degradation of CRY and PER proteins R-HSA-9932298 1.636770e-01 0.786 0 0
ER-Phagosome pathway R-HSA-1236974 1.888673e-01 0.724 0 0
Developmental Cell Lineages R-HSA-9734767 2.244390e-01 0.649 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.802792e-01 0.744 0 0
Frs2-mediated activation R-HSA-170968 2.031480e-01 0.692 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.701999e-01 0.769 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 1.656799e-01 0.781 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 2.313111e-01 0.636 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.956726e-01 0.708 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.368413e-01 0.864 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 1.981616e-01 0.703 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.488976e-01 0.827 0 0
TBC/RABGAPs R-HSA-8854214 1.874048e-01 0.727 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.155500e-01 0.666 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.763805e-01 0.754 0 0
Signal transduction by L1 R-HSA-445144 1.956726e-01 0.708 0 0
Regulation of insulin secretion R-HSA-422356 2.005658e-01 0.698 0 0
Mitophagy R-HSA-5205647 1.743616e-01 0.759 0 0
Inhibition of PKR R-HSA-169131 1.664730e-01 0.779 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 2.313111e-01 0.636 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 1.432691e-01 0.844 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.874048e-01 0.727 0 0
Biotin transport and metabolism R-HSA-196780 2.506049e-01 0.601 0 0
Rab regulation of trafficking R-HSA-9007101 2.205715e-01 0.656 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.309564e-01 0.636 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 2.299660e-01 0.638 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 1.535073e-01 0.814 0 0
Integration of energy metabolism R-HSA-163685 2.371154e-01 0.625 0 0
Co-stimulation by CD28 R-HSA-389356 2.520747e-01 0.598 0 0
Gap junction trafficking and regulation R-HSA-157858 2.657572e-01 0.576 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.636770e-01 0.786 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.535073e-01 0.814 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.535073e-01 0.814 0 0
CHL1 interactions R-HSA-447041 2.313111e-01 0.636 0 0
Antigen processing-Cross presentation R-HSA-1236975 2.110721e-01 0.676 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 2.313111e-01 0.636 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 2.008348e-01 0.697 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 2.124374e-01 0.673 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.415862e-01 0.849 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 1.855382e-01 0.732 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.008348e-01 0.697 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.168057e-01 0.664 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 2.596498e-01 0.586 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 2.596498e-01 0.586 0 0
Signaling by FGFR2 R-HSA-5654738 1.847069e-01 0.734 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 2.145891e-01 0.668 0 0
Signaling by KIT in disease R-HSA-9669938 2.528825e-01 0.597 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 1.827533e-01 0.738 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.488976e-01 0.827 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 1.981616e-01 0.703 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 1.523491e-01 0.817 0 0
Developmental Biology R-HSA-1266738 1.825169e-01 0.739 0 0
Oncogene Induced Senescence R-HSA-2559585 1.877191e-01 0.726 0 0
Downstream signal transduction R-HSA-186763 2.498361e-01 0.602 0 0
TCR signaling R-HSA-202403 1.530103e-01 0.815 0 0
Signal regulatory protein family interactions R-HSA-391160 2.266367e-01 0.645 0 0
Signaling by FGFR4 R-HSA-5654743 1.874048e-01 0.727 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.852853e-01 0.732 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.528825e-01 0.597 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.439419e-01 0.842 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 1.874048e-01 0.727 0 0
NRAGE signals death through JNK R-HSA-193648 2.321853e-01 0.634 0 0
Signaling by FGFR3 R-HSA-5654741 2.124374e-01 0.673 0 0
Signaling by FGFR1 R-HSA-5654736 2.321853e-01 0.634 0 0
MHC class II antigen presentation R-HSA-2132295 1.908650e-01 0.719 0 0
Hedgehog ligand biogenesis R-HSA-5358346 1.745561e-01 0.758 0 0
Infectious disease R-HSA-5663205 2.565858e-01 0.591 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 2.313111e-01 0.636 0 0
Interleukin-18 signaling R-HSA-9012546 2.647667e-01 0.577 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.333991e-01 0.632 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.726842e-01 0.564 0 0
Gluconeogenesis R-HSA-70263 1.434658e-01 0.843 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.369946e-01 0.863 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.488976e-01 0.827 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 1.852853e-01 0.732 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 1.523491e-01 0.817 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 2.124374e-01 0.673 0 0
Plasma lipoprotein clearance R-HSA-8964043 2.446760e-01 0.611 0 0
Hedgehog 'on' state R-HSA-5632684 1.890279e-01 0.723 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.656799e-01 0.781 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 2.313111e-01 0.636 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.031480e-01 0.692 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 2.143051e-01 0.669 0 0
Inositol phosphate metabolism R-HSA-1483249 1.669614e-01 0.777 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 2.143051e-01 0.669 0 0
HDL assembly R-HSA-8963896 2.266367e-01 0.645 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.657572e-01 0.576 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.775743e-01 0.751 0 0
Glycogen storage diseases R-HSA-3229121 1.432691e-01 0.844 0 0
Signaling by TGFB family members R-HSA-9006936 2.740212e-01 0.562 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 2.748569e-01 0.561 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.748569e-01 0.561 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.749194e-01 0.561 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.749194e-01 0.561 0 0
Phosphorylation of the APC/C R-HSA-176412 2.749194e-01 0.561 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 2.749194e-01 0.561 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 2.749194e-01 0.561 0 0
Prolonged ERK activation events R-HSA-169893 2.749194e-01 0.561 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 2.749194e-01 0.561 0 0
Macroautophagy R-HSA-1632852 2.774679e-01 0.557 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.824153e-01 0.549 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.824153e-01 0.549 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.824153e-01 0.549 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.824153e-01 0.549 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.824153e-01 0.549 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.838686e-01 0.547 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.840230e-01 0.547 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.840230e-01 0.547 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 2.840230e-01 0.547 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 2.840230e-01 0.547 0 0
PKR-mediated signaling R-HSA-9833482 2.844572e-01 0.546 0 0
Signaling by FGFR1 in disease R-HSA-5655302 2.902665e-01 0.537 0 0
Translation of Structural Proteins R-HSA-9683701 2.902665e-01 0.537 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.927353e-01 0.534 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.927353e-01 0.534 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.927353e-01 0.534 0 0
Plasma lipoprotein assembly R-HSA-8963898 2.927353e-01 0.534 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 2.936923e-01 0.532 0 0
Signaling by FGFR R-HSA-190236 2.941146e-01 0.531 0 0
Aquaporin-mediated transport R-HSA-445717 2.954047e-01 0.530 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 2.960065e-01 0.529 0 0
WNT mediated activation of DVL R-HSA-201688 2.982242e-01 0.525 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.982242e-01 0.525 0 0
Calcineurin activates NFAT R-HSA-2025928 2.982242e-01 0.525 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 2.982242e-01 0.525 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 2.982242e-01 0.525 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 2.982242e-01 0.525 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 2.982242e-01 0.525 0 0
ARMS-mediated activation R-HSA-170984 2.982242e-01 0.525 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 2.982242e-01 0.525 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 2.982242e-01 0.525 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 2.994554e-01 0.524 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 2.994554e-01 0.524 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.994554e-01 0.524 0 0
Resolution of D-Loop Structures R-HSA-5693537 3.014402e-01 0.521 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.052485e-01 0.515 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.052485e-01 0.515 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.052485e-01 0.515 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.052485e-01 0.515 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 3.052485e-01 0.515 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.058482e-01 0.514 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.078993e-01 0.512 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 3.078993e-01 0.512 0 0
Neurexins and neuroligins R-HSA-6794361 3.078993e-01 0.512 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 3.078993e-01 0.512 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 3.082545e-01 0.511 0 0
HDMs demethylate histones R-HSA-3214842 3.129688e-01 0.504 0 0
ABC-family proteins mediated transport R-HSA-382556 3.149071e-01 0.502 0 0
Cellular response to chemical stress R-HSA-9711123 3.175264e-01 0.498 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 3.190158e-01 0.496 0 0
Signaling by NOTCH2 R-HSA-1980145 3.190158e-01 0.496 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 3.198460e-01 0.495 0 0
Response of Mtb to phagocytosis R-HSA-9637690 3.215717e-01 0.493 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 3.222357e-01 0.492 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.240973e-01 0.489 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 3.240973e-01 0.489 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 3.240973e-01 0.489 0 0
Uptake and function of anthrax toxins R-HSA-5210891 3.240973e-01 0.489 0 0
Protein folding R-HSA-391251 3.281321e-01 0.484 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 3.314302e-01 0.480 0 0
Folding of actin by CCT/TriC R-HSA-390450 3.314302e-01 0.480 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 3.314302e-01 0.480 0 0
Regulation of CDH11 function R-HSA-9762292 3.314302e-01 0.480 0 0
Interleukin-27 signaling R-HSA-9020956 3.314302e-01 0.480 0 0
Maturation of spike protein R-HSA-9683686 3.314302e-01 0.480 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 3.314302e-01 0.480 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.314302e-01 0.480 0 0
Signaling by Leptin R-HSA-2586552 3.314302e-01 0.480 0 0
Myogenesis R-HSA-525793 3.333204e-01 0.477 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 3.333204e-01 0.477 0 0
Suppression of phagosomal maturation R-HSA-9637687 3.333204e-01 0.477 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 3.367079e-01 0.473 0 0
Gap junction trafficking R-HSA-190828 3.374070e-01 0.472 0 0
RMTs methylate histone arginines R-HSA-3214858 3.374070e-01 0.472 0 0
Cyclin D associated events in G1 R-HSA-69231 3.374070e-01 0.472 0 0
G1 Phase R-HSA-69236 3.374070e-01 0.472 0 0
ER to Golgi Anterograde Transport R-HSA-199977 3.374490e-01 0.472 0 0
Polo-like kinase mediated events R-HSA-156711 3.487382e-01 0.458 0 0
Transport of connexons to the plasma membrane R-HSA-190872 3.487382e-01 0.458 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 3.532255e-01 0.452 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.533249e-01 0.452 0 0
Insulin processing R-HSA-264876 3.537290e-01 0.451 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 3.544760e-01 0.450 0 0
RNA Polymerase III Transcription R-HSA-74158 3.544760e-01 0.450 0 0
G1/S-Specific Transcription R-HSA-69205 3.544760e-01 0.450 0 0
Signaling by NOTCH1 R-HSA-1980143 3.582184e-01 0.446 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 3.618006e-01 0.442 0 0
PECAM1 interactions R-HSA-210990 3.641750e-01 0.439 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 3.641750e-01 0.439 0 0
Bicarbonate transporters R-HSA-425381 3.641750e-01 0.439 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 3.641750e-01 0.439 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 3.641750e-01 0.439 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 3.657204e-01 0.437 0 0
Axonal growth stimulation R-HSA-209563 3.657204e-01 0.437 0 0
Defective ABCC2 causes DJS R-HSA-5679001 3.657204e-01 0.437 0 0
Invadopodia formation R-HSA-8941237 3.657204e-01 0.437 0 0
MET activates PTPN11 R-HSA-8865999 3.657204e-01 0.437 0 0
FasL/ CD95L signaling R-HSA-75157 3.657204e-01 0.437 0 0
MET interacts with TNS proteins R-HSA-8875513 3.657204e-01 0.437 0 0
Intracellular oxygen transport R-HSA-8981607 3.657204e-01 0.437 0 0
Signaling by TGFBR3 R-HSA-9839373 3.692967e-01 0.433 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.705708e-01 0.431 0 0
Neutrophil degranulation R-HSA-6798695 3.718265e-01 0.430 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 3.732808e-01 0.428 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 3.732808e-01 0.428 0 0
Other interleukin signaling R-HSA-449836 3.732808e-01 0.428 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 3.738733e-01 0.427 0 0
Insulin receptor recycling R-HSA-77387 3.741365e-01 0.427 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 3.741365e-01 0.427 0 0
Pyruvate metabolism R-HSA-70268 3.782417e-01 0.422 0 0
G alpha (12/13) signalling events R-HSA-416482 3.835825e-01 0.416 0 0
RNA Polymerase II Transcription R-HSA-73857 3.838665e-01 0.416 1 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 3.852944e-01 0.414 0 0
MET promotes cell motility R-HSA-8875878 3.900843e-01 0.409 0 0
Activation of RAC1 R-HSA-428540 3.962876e-01 0.402 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 3.962876e-01 0.402 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 3.962876e-01 0.402 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 3.962876e-01 0.402 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 3.962876e-01 0.402 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 3.962876e-01 0.402 0 0
Sodium/Calcium exchangers R-HSA-425561 3.962876e-01 0.402 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.976369e-01 0.401 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.976369e-01 0.401 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.976369e-01 0.401 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.976369e-01 0.401 0 0
Formation of definitive endoderm R-HSA-9823730 3.976369e-01 0.401 0 0
Protein hydroxylation R-HSA-9629569 3.976369e-01 0.401 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 3.976369e-01 0.401 0 0
Transmission across Chemical Synapses R-HSA-112315 3.983381e-01 0.400 1 0
Intraflagellar transport R-HSA-5620924 4.012912e-01 0.397 0 0
Metal ion SLC transporters R-HSA-425410 4.012912e-01 0.397 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 4.078508e-01 0.389 0 0
RAS processing R-HSA-9648002 4.078508e-01 0.389 0 0
Downstream TCR signaling R-HSA-202424 4.142902e-01 0.383 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.147332e-01 0.382 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.209320e-01 0.376 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.209320e-01 0.376 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.209320e-01 0.376 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.209320e-01 0.376 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.209320e-01 0.376 0 0
Regulation of gap junction activity R-HSA-191650 4.209320e-01 0.376 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.209320e-01 0.376 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.209320e-01 0.376 0 0
NADE modulates death signalling R-HSA-205025 4.209320e-01 0.376 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 4.209320e-01 0.376 0 0
Lagging Strand Synthesis R-HSA-69186 4.217273e-01 0.375 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 4.217273e-01 0.375 0 0
Basigin interactions R-HSA-210991 4.217273e-01 0.375 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 4.255459e-01 0.371 0 0
Attenuation phase R-HSA-3371568 4.255459e-01 0.371 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 4.255459e-01 0.371 0 0
Polymerase switching R-HSA-69091 4.276302e-01 0.369 0 0
Leading Strand Synthesis R-HSA-69109 4.276302e-01 0.369 0 0
Scavenging by Class F Receptors R-HSA-3000484 4.276302e-01 0.369 0 0
Regulation of IFNG signaling R-HSA-877312 4.276302e-01 0.369 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 4.276302e-01 0.369 0 0
Repression of WNT target genes R-HSA-4641265 4.276302e-01 0.369 0 0
Interleukin-35 Signalling R-HSA-8984722 4.276302e-01 0.369 0 0
Signaling by LTK R-HSA-9842663 4.276302e-01 0.369 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 4.276302e-01 0.369 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 4.299512e-01 0.367 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 4.316921e-01 0.365 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 4.348239e-01 0.362 0 0
MAP kinase activation R-HSA-450294 4.389417e-01 0.358 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 4.415966e-01 0.355 0 0
Interleukin-1 signaling R-HSA-9020702 4.415966e-01 0.355 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.431373e-01 0.353 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 4.454815e-01 0.351 0 0
Mitochondrial calcium ion transport R-HSA-8949215 4.454815e-01 0.351 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 4.503330e-01 0.346 0 0
Signaling by PDGF R-HSA-186797 4.534711e-01 0.343 0 0
Processing of SMDT1 R-HSA-8949664 4.580934e-01 0.339 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 4.580934e-01 0.339 0 0
Interleukin-6 signaling R-HSA-1059683 4.580934e-01 0.339 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 4.605945e-01 0.337 0 0
HIV Transcription Initiation R-HSA-167161 4.605945e-01 0.337 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 4.605945e-01 0.337 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 4.688374e-01 0.329 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 4.688374e-01 0.329 0 0
Notch-HLH transcription pathway R-HSA-350054 4.688374e-01 0.329 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 4.688374e-01 0.329 0 0
Cardiac conduction R-HSA-5576891 4.691458e-01 0.329 1 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 4.713407e-01 0.327 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 4.713407e-01 0.327 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 4.713407e-01 0.327 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 4.713407e-01 0.327 0 0
PTK6 Down-Regulation R-HSA-8849472 4.713407e-01 0.327 0 0
Activation of AKT2 R-HSA-165158 4.713407e-01 0.327 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 4.713407e-01 0.327 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.713407e-01 0.327 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 4.713407e-01 0.327 0 0
Muscarinic acetylcholine receptors R-HSA-390648 4.713407e-01 0.327 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 4.713407e-01 0.327 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 4.713407e-01 0.327 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 4.713407e-01 0.327 0 0
NrCAM interactions R-HSA-447038 4.713407e-01 0.327 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 4.713407e-01 0.327 0 0
Protein-protein interactions at synapses R-HSA-6794362 4.724867e-01 0.326 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 4.743711e-01 0.324 0 0
Nuclear RNA decay R-HSA-9930044 4.743711e-01 0.324 0 0
Circadian clock R-HSA-9909396 4.791322e-01 0.320 0 0
Ion transport by P-type ATPases R-HSA-936837 4.822831e-01 0.317 1 1
Iron uptake and transport R-HSA-917937 4.837922e-01 0.315 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 4.850334e-01 0.314 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 4.875930e-01 0.312 0 0
Regulation of KIT signaling R-HSA-1433559 4.875930e-01 0.312 0 0
Signaling by FGFR4 in disease R-HSA-5655291 4.875930e-01 0.312 0 0
Zinc transporters R-HSA-435354 4.875930e-01 0.312 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 4.917408e-01 0.308 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 4.937508e-01 0.306 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 4.937508e-01 0.306 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 4.949941e-01 0.305 0 0
Signaling by SCF-KIT R-HSA-1433557 4.949941e-01 0.305 0 0
Cellular response to hypoxia R-HSA-1234174 4.965325e-01 0.304 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.982123e-01 0.303 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 4.985041e-01 0.302 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 5.096147e-01 0.293 0 0
Chaperonin-mediated protein folding R-HSA-390466 5.098943e-01 0.293 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 5.111907e-01 0.291 0 0
Netrin-1 signaling R-HSA-373752 5.118855e-01 0.291 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.160659e-01 0.287 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 5.160659e-01 0.287 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.160659e-01 0.287 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 5.160659e-01 0.287 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 5.160659e-01 0.287 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 5.160659e-01 0.287 0 0
Other semaphorin interactions R-HSA-416700 5.160659e-01 0.287 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 5.160659e-01 0.287 0 0
DNA Damage Reversal R-HSA-73942 5.160659e-01 0.287 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.173640e-01 0.286 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 5.173640e-01 0.286 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.173640e-01 0.286 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.173640e-01 0.286 0 0
TRAIL signaling R-HSA-75158 5.173640e-01 0.286 0 0
Pentose phosphate pathway disease R-HSA-6791465 5.173640e-01 0.286 0 0
PDE3B signalling R-HSA-165160 5.173640e-01 0.286 0 0
Cam-PDE 1 activation R-HSA-111957 5.173640e-01 0.286 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.173640e-01 0.286 0 0
PKB-mediated events R-HSA-109703 5.173640e-01 0.286 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 5.173640e-01 0.286 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.173640e-01 0.286 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.173640e-01 0.286 0 0
Intestinal hexose absorption R-HSA-8981373 5.173640e-01 0.286 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 5.173640e-01 0.286 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.173640e-01 0.286 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 5.173640e-01 0.286 0 0
ABC transporter disorders R-HSA-5619084 5.232918e-01 0.281 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 5.285405e-01 0.277 0 0
PERK regulates gene expression R-HSA-381042 5.315575e-01 0.274 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 5.328266e-01 0.273 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 5.328266e-01 0.273 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 5.328266e-01 0.273 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 5.360107e-01 0.271 0 0
Acyl chain remodelling of PS R-HSA-1482801 5.360107e-01 0.271 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 5.360107e-01 0.271 0 0
TGFBR3 expression R-HSA-9839394 5.360107e-01 0.271 0 0
Transcription of the HIV genome R-HSA-167172 5.384727e-01 0.269 0 0
Regulated Necrosis R-HSA-5218859 5.384727e-01 0.269 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 5.434673e-01 0.265 0 0
Atorvastatin ADME R-HSA-9754706 5.434673e-01 0.265 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 5.434673e-01 0.265 0 0
Activation of SMO R-HSA-5635838 5.434673e-01 0.265 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 5.434673e-01 0.265 0 0
Virus Assembly and Release R-HSA-168268 5.434673e-01 0.265 0 0
FOXO-mediated transcription R-HSA-9614085 5.442904e-01 0.264 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 5.449385e-01 0.264 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 5.512384e-01 0.259 0 0
Disorders of transmembrane transporters R-HSA-5619115 5.527970e-01 0.257 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 5.532889e-01 0.257 0 0
MyD88-independent TLR4 cascade R-HSA-166166 5.532889e-01 0.257 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 5.593831e-01 0.252 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 5.593831e-01 0.252 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 5.593831e-01 0.252 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 5.593831e-01 0.252 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 5.593831e-01 0.252 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 5.593831e-01 0.252 0 0
G2/M DNA replication checkpoint R-HSA-69478 5.593831e-01 0.252 0 0
Neurofascin interactions R-HSA-447043 5.593831e-01 0.252 0 0
Lactose synthesis R-HSA-5653890 5.593831e-01 0.252 0 0
VLDL assembly R-HSA-8866423 5.593831e-01 0.252 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 5.610609e-01 0.251 0 0
Interleukin-17 signaling R-HSA-448424 5.656250e-01 0.247 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 5.697681e-01 0.244 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 5.697681e-01 0.244 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 5.697681e-01 0.244 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 5.697681e-01 0.244 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 5.768908e-01 0.239 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 5.779997e-01 0.238 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 5.779997e-01 0.238 0 0
Signaling by Insulin receptor R-HSA-74752 5.819044e-01 0.235 0 0
Interleukin-1 family signaling R-HSA-446652 5.830644e-01 0.234 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 5.854923e-01 0.232 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 5.854923e-01 0.232 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 5.949521e-01 0.226 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 5.949521e-01 0.226 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 5.949521e-01 0.226 0 0
Specification of primordial germ cells R-HSA-9827857 5.949521e-01 0.226 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 5.977462e-01 0.223 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 5.977462e-01 0.223 0 0
IFNG signaling activates MAPKs R-HSA-9732724 5.977462e-01 0.223 0 0
Disinhibition of SNARE formation R-HSA-114516 5.977462e-01 0.223 0 0
TRIF-mediated programmed cell death R-HSA-2562578 5.977462e-01 0.223 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 5.977462e-01 0.223 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 5.977462e-01 0.223 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 5.977462e-01 0.223 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 5.977462e-01 0.223 0 0
LDL remodeling R-HSA-8964041 5.977462e-01 0.223 0 0
VLDL clearance R-HSA-8964046 5.977462e-01 0.223 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 5.980748e-01 0.223 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.988614e-01 0.223 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 6.026477e-01 0.220 0 0
Signaling by ALK R-HSA-201556 6.026477e-01 0.220 0 0
Adaptive Immune System R-HSA-1280218 6.037038e-01 0.219 0 0
Ca2+ pathway R-HSA-4086398 6.049120e-01 0.218 0 0
PI3K Cascade R-HSA-109704 6.076151e-01 0.216 0 0
RSV-host interactions R-HSA-9833110 6.106190e-01 0.214 0 0
Heme signaling R-HSA-9707616 6.126366e-01 0.213 0 0
SLC transporter disorders R-HSA-5619102 6.150995e-01 0.211 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 6.175136e-01 0.209 0 0
Regulation of gene expression in beta cells R-HSA-210745 6.175136e-01 0.209 0 0
Signaling by FGFR in disease R-HSA-1226099 6.175851e-01 0.209 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 6.190144e-01 0.208 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.190144e-01 0.208 0 0
Platelet sensitization by LDL R-HSA-432142 6.190144e-01 0.208 0 0
Mismatch Repair R-HSA-5358508 6.190144e-01 0.208 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.190144e-01 0.208 0 0
Presynaptic function of Kainate receptors R-HSA-500657 6.190144e-01 0.208 0 0
Nephron development R-HSA-9831926 6.190144e-01 0.208 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 6.190144e-01 0.208 0 0
Generation of second messenger molecules R-HSA-202433 6.193658e-01 0.208 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.224113e-01 0.206 0 0
Interferon alpha/beta signaling R-HSA-909733 6.261413e-01 0.203 0 0
Regulation by c-FLIP R-HSA-3371378 6.327713e-01 0.199 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.327713e-01 0.199 0 0
phospho-PLA2 pathway R-HSA-111995 6.327713e-01 0.199 0 0
Dimerization of procaspase-8 R-HSA-69416 6.327713e-01 0.199 0 0
MET receptor recycling R-HSA-8875656 6.327713e-01 0.199 0 0
Co-stimulation by ICOS R-HSA-9927354 6.327713e-01 0.199 0 0
Interleukin-9 signaling R-HSA-8985947 6.327713e-01 0.199 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.327713e-01 0.199 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 6.327713e-01 0.199 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 6.327713e-01 0.199 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.327713e-01 0.199 0 0
Sodium/Proton exchangers R-HSA-425986 6.327713e-01 0.199 0 0
Intestinal absorption R-HSA-8963676 6.327713e-01 0.199 0 0
Interleukin-23 signaling R-HSA-9020933 6.327713e-01 0.199 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 6.356349e-01 0.197 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 6.356349e-01 0.197 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 6.363046e-01 0.196 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 6.363046e-01 0.196 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 6.363046e-01 0.196 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 6.363046e-01 0.196 0 0
IGF1R signaling cascade R-HSA-2428924 6.393755e-01 0.194 0 0
Insulin receptor signalling cascade R-HSA-74751 6.393755e-01 0.194 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.419595e-01 0.192 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.419595e-01 0.192 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.419595e-01 0.192 0 0
The NLRP3 inflammasome R-HSA-844456 6.419595e-01 0.192 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.514461e-01 0.186 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 6.514461e-01 0.186 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 6.520510e-01 0.186 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 6.523239e-01 0.186 0 0
Translation of Structural Proteins R-HSA-9694635 6.542292e-01 0.184 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 6.544404e-01 0.184 0 0
Generic Transcription Pathway R-HSA-212436 6.568934e-01 0.183 1 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 6.620151e-01 0.179 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 6.637994e-01 0.178 0 0
Creatine metabolism R-HSA-71288 6.637994e-01 0.178 0 0
CASP8 activity is inhibited R-HSA-5218900 6.647486e-01 0.177 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 6.647486e-01 0.177 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 6.647486e-01 0.177 0 0
p75NTR regulates axonogenesis R-HSA-193697 6.647486e-01 0.177 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 6.647486e-01 0.177 0 0
Interleukin-21 signaling R-HSA-9020958 6.647486e-01 0.177 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 6.647486e-01 0.177 0 0
Regulated proteolysis of p75NTR R-HSA-193692 6.647486e-01 0.177 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 6.647486e-01 0.177 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 6.649090e-01 0.177 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 6.649090e-01 0.177 0 0
Hemostasis R-HSA-109582 6.698062e-01 0.174 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 6.719175e-01 0.173 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 6.793678e-01 0.168 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 6.797180e-01 0.168 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 6.845526e-01 0.165 0 0
G-protein activation R-HSA-202040 6.845526e-01 0.165 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.845526e-01 0.165 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 6.845526e-01 0.165 0 0
Adipogenesis R-HSA-9843745 6.855367e-01 0.164 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 6.887358e-01 0.162 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 6.915629e-01 0.160 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 6.924270e-01 0.160 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 6.924270e-01 0.160 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 6.939431e-01 0.159 0 0
Receptor Mediated Mitophagy R-HSA-8934903 6.939431e-01 0.159 0 0
Regulation of the apoptosome activity R-HSA-9627069 6.939431e-01 0.159 0 0
Formation of apoptosome R-HSA-111458 6.939431e-01 0.159 0 0
Binding and entry of HIV virion R-HSA-173107 6.939431e-01 0.159 0 0
DNA replication initiation R-HSA-68952 6.939431e-01 0.159 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 6.939431e-01 0.159 0 0
CASP4 inflammasome assembly R-HSA-9948001 6.939431e-01 0.159 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 6.939431e-01 0.159 0 0
Proteasome assembly R-HSA-9907900 6.960743e-01 0.157 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.001891e-01 0.155 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.042427e-01 0.152 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 7.042427e-01 0.152 0 0
Ribavirin ADME R-HSA-9755088 7.042427e-01 0.152 0 0
IRS-mediated signalling R-HSA-112399 7.042864e-01 0.152 0 0
Ion channel transport R-HSA-983712 7.044960e-01 0.152 1 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 7.048981e-01 0.152 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 7.048981e-01 0.152 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.048981e-01 0.152 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 7.204101e-01 0.142 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 7.204101e-01 0.142 0 0
eNOS activation R-HSA-203615 7.204101e-01 0.142 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 7.204101e-01 0.142 0 0
Gap junction assembly R-HSA-190861 7.204101e-01 0.142 0 0
Signaling by APC mutants R-HSA-4839744 7.205968e-01 0.142 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 7.205968e-01 0.142 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 7.205968e-01 0.142 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 7.205968e-01 0.142 0 0
Ionotropic activity of kainate receptors R-HSA-451306 7.205968e-01 0.142 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 7.205968e-01 0.142 0 0
vRNA Synthesis R-HSA-192814 7.205968e-01 0.142 0 0
vRNP Assembly R-HSA-192905 7.205968e-01 0.142 0 0
Chylomicron assembly R-HSA-8963888 7.205968e-01 0.142 0 0
Propionyl-CoA catabolism R-HSA-71032 7.205968e-01 0.142 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 7.205968e-01 0.142 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.205968e-01 0.142 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 7.208648e-01 0.142 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 7.228974e-01 0.141 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.228974e-01 0.141 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 7.228974e-01 0.141 0 0
LDL clearance R-HSA-8964038 7.228974e-01 0.141 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 7.228974e-01 0.141 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.269833e-01 0.138 0 0
Extension of Telomeres R-HSA-180786 7.286215e-01 0.137 0 0
Peroxisomal protein import R-HSA-9033241 7.286215e-01 0.137 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.286919e-01 0.137 0 0
Transferrin endocytosis and recycling R-HSA-917977 7.352798e-01 0.134 0 0
Signalling to ERKs R-HSA-187687 7.352798e-01 0.134 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 7.352798e-01 0.134 0 0
Interferon gamma signaling R-HSA-877300 7.360305e-01 0.133 1 1
tRNA processing R-HSA-72306 7.368238e-01 0.133 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.405477e-01 0.130 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.405477e-01 0.130 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 7.405477e-01 0.130 0 0
Biosynthesis of maresins R-HSA-9018682 7.405477e-01 0.130 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 7.429090e-01 0.129 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 7.437998e-01 0.129 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.449308e-01 0.128 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 7.449308e-01 0.128 0 0
Signaling by GSK3beta mutants R-HSA-5339716 7.449308e-01 0.128 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 7.449308e-01 0.128 0 0
Signaling by AMER1 mutants R-HSA-4839748 7.449308e-01 0.128 0 0
Signaling by AXIN mutants R-HSA-4839735 7.449308e-01 0.128 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 7.449308e-01 0.128 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 7.449308e-01 0.128 0 0
Immune System R-HSA-168256 7.485475e-01 0.126 1 0
Lysosome Vesicle Biogenesis R-HSA-432720 7.495170e-01 0.125 0 0
Triglyceride catabolism R-HSA-163560 7.495170e-01 0.125 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 7.572271e-01 0.121 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 7.572271e-01 0.121 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.572271e-01 0.121 0 0
Mitochondrial RNA degradation R-HSA-9836573 7.572271e-01 0.121 0 0
Interleukin-6 family signaling R-HSA-6783589 7.572271e-01 0.121 0 0
Stimuli-sensing channels R-HSA-2672351 7.622486e-01 0.118 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 7.663334e-01 0.116 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 7.671468e-01 0.115 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 7.671468e-01 0.115 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 7.671468e-01 0.115 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 7.671468e-01 0.115 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 7.671468e-01 0.115 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.671468e-01 0.115 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 7.671468e-01 0.115 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 7.671468e-01 0.115 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 7.671468e-01 0.115 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 7.671468e-01 0.115 0 0
OAS antiviral response R-HSA-8983711 7.671468e-01 0.115 0 0
Azathioprine ADME R-HSA-9748787 7.726486e-01 0.112 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 7.728650e-01 0.112 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 7.729706e-01 0.112 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.729706e-01 0.112 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 7.729706e-01 0.112 0 0
Laminin interactions R-HSA-3000157 7.729706e-01 0.112 0 0
Tight junction interactions R-HSA-420029 7.729706e-01 0.112 0 0
Hyaluronan degradation R-HSA-2160916 7.729706e-01 0.112 0 0
Neuronal System R-HSA-112316 7.745654e-01 0.111 1 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 7.761425e-01 0.110 0 0
Adenylate cyclase activating pathway R-HSA-170660 7.874290e-01 0.104 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 7.874290e-01 0.104 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 7.874290e-01 0.104 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 7.874290e-01 0.104 0 0
Formation of axial mesoderm R-HSA-9796292 7.874290e-01 0.104 0 0
MET activates PTK2 signaling R-HSA-8874081 7.878148e-01 0.104 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 7.878148e-01 0.104 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 7.878148e-01 0.104 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.878148e-01 0.104 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 7.883488e-01 0.103 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 7.885585e-01 0.103 0 0
Integrin cell surface interactions R-HSA-216083 7.933656e-01 0.101 0 0
Diseases of Immune System R-HSA-5260271 8.003970e-01 0.097 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.003970e-01 0.097 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 8.017969e-01 0.096 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 8.017969e-01 0.096 0 0
Cristae formation R-HSA-8949613 8.017969e-01 0.096 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 8.017969e-01 0.096 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.017969e-01 0.096 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 8.017969e-01 0.096 0 0
Nucleotide biosynthesis R-HSA-8956320 8.048120e-01 0.094 0 0
Removal of the Flap Intermediate R-HSA-69166 8.059457e-01 0.094 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.059457e-01 0.094 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.059457e-01 0.094 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.059457e-01 0.094 0 0
Hydrolysis of LPC R-HSA-1483115 8.059457e-01 0.094 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.059457e-01 0.094 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 8.059457e-01 0.094 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 8.059457e-01 0.094 0 0
Physiological factors R-HSA-5578768 8.059457e-01 0.094 0 0
Malate-aspartate shuttle R-HSA-9856872 8.059457e-01 0.094 0 0
Non-canonical inflammasome activation R-HSA-9686114 8.059457e-01 0.094 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.059457e-01 0.094 0 0
Maturation of spike protein R-HSA-9694548 8.116744e-01 0.091 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.149543e-01 0.089 0 0
HIV elongation arrest and recovery R-HSA-167287 8.149543e-01 0.089 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.149543e-01 0.089 0 0
Pausing and recovery of HIV elongation R-HSA-167290 8.149543e-01 0.089 0 0
Inflammasomes R-HSA-622312 8.149543e-01 0.089 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.189027e-01 0.087 0 0
Intra-Golgi traffic R-HSA-6811438 8.224077e-01 0.085 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.224077e-01 0.085 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.228505e-01 0.085 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 8.228505e-01 0.085 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.228505e-01 0.085 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.228505e-01 0.085 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 8.228505e-01 0.085 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 8.228505e-01 0.085 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.228505e-01 0.085 0 0
G alpha (z) signalling events R-HSA-418597 8.241268e-01 0.084 0 0
Parasitic Infection Pathways R-HSA-9824443 8.272239e-01 0.082 0 0
Leishmania infection R-HSA-9658195 8.272239e-01 0.082 0 0
mRNA Capping R-HSA-72086 8.273246e-01 0.082 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.273246e-01 0.082 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 8.273246e-01 0.082 0 0
Platelet calcium homeostasis R-HSA-418360 8.273246e-01 0.082 0 0
Neddylation R-HSA-8951664 8.298449e-01 0.081 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.334627e-01 0.079 0 0
Mitochondrial protein degradation R-HSA-9837999 8.334627e-01 0.079 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 8.365870e-01 0.077 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.382835e-01 0.077 0 0
Killing mechanisms R-HSA-9664420 8.382835e-01 0.077 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 8.382835e-01 0.077 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.382835e-01 0.077 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.382835e-01 0.077 0 0
Differentiation of T cells R-HSA-9945266 8.382835e-01 0.077 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.382835e-01 0.077 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.389450e-01 0.076 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.389450e-01 0.076 0 0
Neurotransmitter clearance R-HSA-112311 8.389450e-01 0.076 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.389450e-01 0.076 0 0
Interleukin-37 signaling R-HSA-9008059 8.389450e-01 0.076 0 0
Parasite infection R-HSA-9664407 8.442201e-01 0.074 0 0
Leishmania phagocytosis R-HSA-9664417 8.442201e-01 0.074 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.442201e-01 0.074 0 0
Cargo concentration in the ER R-HSA-5694530 8.498523e-01 0.071 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.498523e-01 0.071 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 8.519632e-01 0.070 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 8.523728e-01 0.069 0 0
Fibronectin matrix formation R-HSA-1566977 8.523728e-01 0.069 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.523728e-01 0.069 0 0
Passive transport by Aquaporins R-HSA-432047 8.523728e-01 0.069 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 8.523728e-01 0.069 0 0
Coenzyme A biosynthesis R-HSA-196783 8.523728e-01 0.069 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.537560e-01 0.069 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 8.591457e-01 0.066 0 0
Signaling by WNT in cancer R-HSA-4791275 8.600825e-01 0.065 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.600825e-01 0.065 0 0
Somitogenesis R-HSA-9824272 8.602544e-01 0.065 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 8.652354e-01 0.063 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.652354e-01 0.063 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 8.652354e-01 0.063 0 0
Choline catabolism R-HSA-6798163 8.652354e-01 0.063 0 0
Disease R-HSA-1643685 8.683254e-01 0.061 1 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.685349e-01 0.061 0 0
Diseases of DNA repair R-HSA-9675135 8.685349e-01 0.061 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 8.696708e-01 0.061 0 0
FCERI mediated NF-kB activation R-HSA-2871837 8.700438e-01 0.060 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 8.746133e-01 0.058 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 8.763792e-01 0.057 0 0
Apoptotic factor-mediated response R-HSA-111471 8.769780e-01 0.057 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 8.769780e-01 0.057 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 8.769780e-01 0.057 0 0
Tie2 Signaling R-HSA-210993 8.769780e-01 0.057 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.783973e-01 0.056 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.786512e-01 0.056 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.786512e-01 0.056 0 0
Heme degradation R-HSA-189483 8.786512e-01 0.056 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.796273e-01 0.056 0 0
Mitochondrial protein import R-HSA-1268020 8.796273e-01 0.056 0 0
NGF-stimulated transcription R-HSA-9031628 8.838052e-01 0.054 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 8.870569e-01 0.052 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 8.870569e-01 0.052 0 0
Signal amplification R-HSA-392518 8.870569e-01 0.052 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.870569e-01 0.052 0 0
Hyaluronan metabolism R-HSA-2142845 8.870569e-01 0.052 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.870569e-01 0.052 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.870569e-01 0.052 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 8.876981e-01 0.052 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 8.876981e-01 0.052 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 8.876981e-01 0.052 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 8.876981e-01 0.052 0 0
E2F mediated regulation of DNA replication R-HSA-113510 8.876981e-01 0.052 0 0
Signaling by NTRKs R-HSA-166520 8.881377e-01 0.052 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 8.890117e-01 0.051 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.949198e-01 0.048 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.949198e-01 0.048 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.949198e-01 0.048 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 8.949198e-01 0.048 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.963495e-01 0.048 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.974730e-01 0.047 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 8.974846e-01 0.047 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 8.974846e-01 0.047 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 8.974846e-01 0.047 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 8.974846e-01 0.047 0 0
Acyl chain remodelling of PI R-HSA-1482922 8.974846e-01 0.047 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 8.974846e-01 0.047 0 0
GPVI-mediated activation cascade R-HSA-114604 9.022708e-01 0.045 0 0
The phototransduction cascade R-HSA-2514856 9.037492e-01 0.044 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.041193e-01 0.044 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 9.064188e-01 0.043 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.064188e-01 0.043 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.064188e-01 0.043 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.064188e-01 0.043 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.064188e-01 0.043 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.064188e-01 0.043 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.067026e-01 0.043 0 0
Toll-like Receptor Cascades R-HSA-168898 9.074478e-01 0.042 0 0
Protein localization R-HSA-9609507 9.078039e-01 0.042 0 0
Collagen formation R-HSA-1474290 9.106255e-01 0.041 0 0
Extracellular matrix organization R-HSA-1474244 9.130526e-01 0.040 0 0
Serine metabolism R-HSA-977347 9.145748e-01 0.039 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.145748e-01 0.039 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.152696e-01 0.038 0 0
Elastic fibre formation R-HSA-1566948 9.155532e-01 0.038 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.161406e-01 0.038 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 9.215400e-01 0.035 0 0
Pentose phosphate pathway R-HSA-71336 9.215400e-01 0.035 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.215400e-01 0.035 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.220205e-01 0.035 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.220205e-01 0.035 0 0
Cellular hexose transport R-HSA-189200 9.220205e-01 0.035 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.231433e-01 0.035 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 9.271252e-01 0.033 0 0
HIV Transcription Elongation R-HSA-167169 9.271252e-01 0.033 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 9.271252e-01 0.033 0 0
Interleukin-2 family signaling R-HSA-451927 9.271252e-01 0.033 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 9.288176e-01 0.032 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.288176e-01 0.032 0 0
Interleukin-20 family signaling R-HSA-8854691 9.288176e-01 0.032 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.288176e-01 0.032 0 0
Formation of the ureteric bud R-HSA-9830674 9.288176e-01 0.032 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.288176e-01 0.032 0 0
Carnitine shuttle R-HSA-200425 9.288176e-01 0.032 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.350226e-01 0.029 0 0
Complex III assembly R-HSA-9865881 9.350226e-01 0.029 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.350226e-01 0.029 0 0
Metabolism of proteins R-HSA-392499 9.362103e-01 0.029 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.371876e-01 0.028 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.399382e-01 0.027 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.406295e-01 0.027 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.406870e-01 0.027 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.406870e-01 0.027 0 0
G protein gated Potassium channels R-HSA-1296059 9.406870e-01 0.027 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.406870e-01 0.027 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.406870e-01 0.027 0 0
Activation of GABAB receptors R-HSA-991365 9.417103e-01 0.026 0 0
GABA B receptor activation R-HSA-977444 9.417103e-01 0.026 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.417103e-01 0.026 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.419684e-01 0.026 0 0
Regulation of beta-cell development R-HSA-186712 9.426867e-01 0.026 0 0
Triglyceride metabolism R-HSA-8979227 9.426867e-01 0.026 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.426867e-01 0.026 0 0
Linoleic acid (LA) metabolism R-HSA-2046105 9.458580e-01 0.024 0 0
TRP channels R-HSA-3295583 9.458580e-01 0.024 0 0
Urea cycle R-HSA-70635 9.458580e-01 0.024 0 0
Sphingolipid catabolism R-HSA-9845614 9.458580e-01 0.024 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.458580e-01 0.024 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 9.458580e-01 0.024 0 0
tRNA Aminoacylation R-HSA-379724 9.463638e-01 0.024 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.463638e-01 0.024 0 0
Metabolism of polyamines R-HSA-351202 9.463638e-01 0.024 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.498204e-01 0.022 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.505784e-01 0.022 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.505784e-01 0.022 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.505784e-01 0.022 0 0
Mitochondrial biogenesis R-HSA-1592230 9.528965e-01 0.021 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.530683e-01 0.021 0 0
Telomere Extension By Telomerase R-HSA-171319 9.548875e-01 0.020 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 9.548875e-01 0.020 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.548875e-01 0.020 0 0
Pyrimidine salvage R-HSA-73614 9.548875e-01 0.020 0 0
Prednisone ADME R-HSA-9757110 9.548875e-01 0.020 0 0
Pyroptosis R-HSA-5620971 9.548875e-01 0.020 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.568854e-01 0.019 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.568854e-01 0.019 0 0
G alpha (s) signalling events R-HSA-418555 9.581844e-01 0.019 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.588212e-01 0.018 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.588212e-01 0.018 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 9.588212e-01 0.018 0 0
Glucagon-type ligand receptors R-HSA-420092 9.588212e-01 0.018 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.617082e-01 0.017 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.617082e-01 0.017 0 0
Post-translational protein modification R-HSA-597592 9.617830e-01 0.017 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 9.624120e-01 0.017 0 0
DAP12 signaling R-HSA-2424491 9.624120e-01 0.017 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.641928e-01 0.016 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.656899e-01 0.015 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.657011e-01 0.015 0 0
Kidney development R-HSA-9830369 9.665576e-01 0.015 0 0
Formation of the cornified envelope R-HSA-6809371 9.671999e-01 0.014 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.686822e-01 0.014 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.687744e-01 0.014 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.714136e-01 0.013 0 0
Recycling of bile acids and salts R-HSA-159418 9.714136e-01 0.013 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.727688e-01 0.012 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.727979e-01 0.012 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.731575e-01 0.012 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.739070e-01 0.011 0 0
ECM proteoglycans R-HSA-3000178 9.746203e-01 0.011 0 0
Metabolism of cofactors R-HSA-8978934 9.746203e-01 0.011 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 9.763263e-01 0.010 0 0
Aspirin ADME R-HSA-9749641 9.779229e-01 0.010 0 0
Paracetamol ADME R-HSA-9753281 9.784198e-01 0.009 0 0
Peptide hormone metabolism R-HSA-2980736 9.790706e-01 0.009 0 0
RUNX2 regulates bone development R-HSA-8941326 9.801571e-01 0.009 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.801571e-01 0.009 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.801571e-01 0.009 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.808135e-01 0.008 0 0
Synthesis of PA R-HSA-1483166 9.815370e-01 0.008 0 0
NCAM1 interactions R-HSA-419037 9.818883e-01 0.008 0 0
Lysine catabolism R-HSA-71064 9.818883e-01 0.008 0 0
Metabolism of folate and pterines R-HSA-196757 9.818883e-01 0.008 0 0
Platelet homeostasis R-HSA-418346 9.823422e-01 0.008 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.829271e-01 0.007 0 0
G alpha (i) signalling events R-HSA-418594 9.829411e-01 0.007 1 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.833865e-01 0.007 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.834685e-01 0.007 0 0
Purine salvage R-HSA-74217 9.834685e-01 0.007 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.840047e-01 0.007 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.842152e-01 0.007 0 0
Gastrulation R-HSA-9758941 9.843911e-01 0.007 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.849109e-01 0.007 0 0
GABA receptor activation R-HSA-977443 9.854087e-01 0.006 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.862276e-01 0.006 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.862276e-01 0.006 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.874294e-01 0.005 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.895278e-01 0.005 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.899879e-01 0.004 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.904418e-01 0.004 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.912761e-01 0.004 0 0
DAP12 interactions R-HSA-2172127 9.912761e-01 0.004 0 0
Amine ligand-binding receptors R-HSA-375280 9.912761e-01 0.004 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.916216e-01 0.004 0 0
PI Metabolism R-HSA-1483255 9.917904e-01 0.004 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.918780e-01 0.004 0 0
Synthesis of PC R-HSA-1483191 9.933671e-01 0.003 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.933671e-01 0.003 0 0
Metabolism of porphyrins R-HSA-189445 9.939172e-01 0.003 0 0
Neurotransmitter release cycle R-HSA-112310 9.939380e-01 0.003 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.939462e-01 0.003 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.949572e-01 0.002 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.955693e-01 0.002 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.955929e-01 0.002 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.961104e-01 0.002 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.962515e-01 0.002 0 0
Glucuronidation R-HSA-156588 9.965011e-01 0.002 0 0
Interleukin-10 signaling R-HSA-6783783 9.965435e-01 0.002 0 0
Innate Immune System R-HSA-168249 9.971731e-01 0.001 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.972918e-01 0.001 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.973239e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.973402e-01 0.001 0 0
RAB geranylgeranylation R-HSA-8873719 9.979782e-01 0.001 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.979782e-01 0.001 0 0
Collagen degradation R-HSA-1442490 9.981548e-01 0.001 0 0
Nucleotide salvage R-HSA-8956321 9.981548e-01 0.001 0 0
PPARA activates gene expression R-HSA-1989781 9.984143e-01 0.001 0 0
Digestion and absorption R-HSA-8963743 9.984632e-01 0.001 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.985975e-01 0.001 0 0
Xenobiotics R-HSA-211981 9.985975e-01 0.001 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.986080e-01 0.001 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.988070e-01 0.001 0 0
COPII-mediated vesicle transport R-HSA-204005 9.991898e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.993054e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.993830e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.993848e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.993848e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.994791e-01 0.000 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.996104e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.996104e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.996468e-01 0.000 1 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.996568e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.997181e-01 0.000 1 0
Peroxisomal lipid metabolism R-HSA-390918 9.997750e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.998092e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.998148e-01 0.000 0 0
Keratinization R-HSA-6805567 9.998437e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.998518e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.998866e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.999028e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999028e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999083e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999179e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999305e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999333e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.999431e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999507e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999636e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999687e-01 0.000 1 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999714e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999732e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999757e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999767e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999790e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999790e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999869e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999870e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999894e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999913e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999925e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.999937e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999953e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999970e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999972e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999981e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999994e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999997e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999997e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999999e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways