TLK1

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A0A2R8Y4L2	S95	Sugiyama	HNRNPA1L3 HNRNPA1P48	RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A5A3E0	T949	Sugiyama	POTEF A26C1B	TVAsSSSLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
A6NMY6	S127	Sugiyama	ANXA2P2 ANX2L2 ANX2P2 LPC2B	AQyDAsELKAsMKGLGtDEDsLIEIICsRtNQELQEINRVy
A6NMY6	T123	Sugiyama	ANXA2P2 ANX2L2 ANX2P2 LPC2B	LKtPAQyDAsELKAsMKGLGtDEDsLIEIICsRtNQELQEI
A6NMY6	T163	Sugiyama	ANXA2P2 ANX2L2 ANX2P2 LPC2B	INRVyKEMYKtDLEKDIIsDtsGDFRKLMVALAKGRRAEDG
O00115	S57	Sugiyama	DNASE2 DNASE2A DNL2	ALRGSGEAAQRGLQYKyLDEssGGWRDGRALINsPEGAVGR
O00115	S58	Sugiyama	DNASE2 DNASE2A DNL2	LRGSGEAAQRGLQYKyLDEssGGWRDGRALINsPEGAVGRS
O00170	T48	Sugiyama	AIP XAP2	FQDGTKATFHYRtLHsDDEGtVLDDsRARGKPMELIIGKKF
O00592	T556	Sugiyama	PODXL PCLP PCLP1	DsWIVPLDNLTKDDLDEEEDtHL__________________
O14950	T160	Sugiyama	MYL12B MRLC2 MYLC2B	DELyREAPIDKKGNFNyIEFtRILKHGAKDKDD________
O15212	S53	Sugiyama	PFDN6 HKE2 PFD6	LEAQLtENNIVKEELALLDGsNVVFKLLGPVLVKQELGEAR
O15355	S349	Sugiyama	PPM1G PPM1C	tTAVVALIRGKQLIVANAGDsRCVVsEAGKALDMsyDHKPE
O43290	T430	Sugiyama	SART1	RKKEKEVVVRADDLLPLGDQtQDGDFGsRLRGRGRRRVsEV
O43615	S193	Sugiyama	TIMM44 MIMT44 TIM44	TAAFRALsQGVEsVKKEIDDsVLGQtGPyRRPQRLRKRTEF
O43670	S371	Sugiyama	ZNF207 BUGZ	PATLTTtsAtsKLIHPDEDIsLEERRAQLPKYQRNLPRPGQ
O43719	S702	Sugiyama	HTATSF1	EDADGKEVEDADEKLFEDDDsNEKLFDEEEDssEKLFDDsD
O43719	S713	Sugiyama	HTATSF1	DEKLFEDDDsNEKLFDEEEDssEKLFDDsDERGTLGGFGSV
O43823	T316	Sugiyama	AKAP8 AKAP95	FGPDGTGRKRKQFQLyEEPDtKLARVDsEGDFsENDDAAGD
O43852	S44	Sugiyama	CALU	KKDRVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQL
O43852	S69	Sugiyama	CALU	HDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKDGFVt
O43852	T177	Sugiyama	CALU	ERRFKMADKDGDLIATKEEFtAFLHPEEyDyMKDIVVQEtM
O43852	T196	Sugiyama	CALU	FtAFLHPEEyDyMKDIVVQEtMEDIDKNADGFIDLEEyIGD
O43852	T254	Sugiyama	CALU	REQFVEFRDKNRDGKMDKEEtKDWILPsDyDHAEAEARHLV
O43852	T89	Sugiyama	CALU	sKERLGKIVSKIDGDKDGFVtVDELKDWIKFAQKRWIyEDV
O60220	S94	Sugiyama	TIMM8A DDP DDP1 TIM8A	SQFILNRLEQTQKSKPVFSEsLsD_________________
O60271	T418	Sugiyama	SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6	DEGADLLGMGREVENLILENtQLLEtKNALNIVKNDLIAKV
O60566	T608	Sugiyama	BUB1B BUBR1 MAD3L SSK1	SEDAIITGFRNVtICPNPEDtCDFARAARFVStPFHEIMSL
O60610	S542	Sugiyama	DIAPH1 DIAP1	ALHSEKQQIATEKQDLEAEVsQLtGEVAKLTKELEDAKKEM
O60841	S66	Sugiyama	EIF5B IF2 KIAA0741	KEKKKQDFDEDDILKELEELsLEAQGIKADREtVAVKPTEN
O60934	S738	Sugiyama	NBN NBS NBS1 P95	ELEEWLRQEMEVQNQHAKEEsLADDLFRyNPyLKRRR____
O75410	S276	Sugiyama	TACC1 KIAA1103	GtPLPKAsYHFsPEELDENtsPLLGDARFQKsPPDLKETPG
O75410	T275	Sugiyama	TACC1 KIAA1103	EGtPLPKAsYHFsPEELDENtsPLLGDARFQKsPPDLKETP
O75436	T102	Sugiyama	VPS26A VPS26	KSNTHEFVNLVKELALPGELtQSRSYDFEFMQVEKPYESYI
O75717	S383	Sugiyama	WDHD1 AND1	LMMAsGRPRQRsHILEDDENsVDIsMLKtGssLLKEEEEDG
O75821	T206	Sugiyama	EIF3G EIF3S4	LGLstGEKEKLPGELEPVQAtQNKtGKYVPPsLRDGAsRRG
O94763	T447	Sugiyama	URI1 C19orf2 NNX3 PPP1R19 RMP URI	SAAEFDDRRGVLRsIsCEEAtCsDtsEsILEEEPQENQKKL
O95218	S181	Sugiyama	ZRANB2 ZIS ZNF265	DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
O95433	T20	Sugiyama	AHSA1 C14orf3 HSPC322	_MAKWGEGDPRWIVEERADAtNVNNWHWtERDASNWSTDKL
O95816	S208	Sugiyama	BAG2	IKLLEHSKGAGSKTLQQNAEsRFN_________________
P00338	T322	Sugiyama	LDHA PIG19	DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P02786	S151	Sugiyama	TFRC	LsEKLDstDFTGtIKLLNENsyVPREAGsQKDENLALyVEN
P04075	S356	Sugiyama	ALDOA ALDA	sLACQGKytPsGQAGAAAsEsLFVsNHAy____________
P04075	S36	Sugiyama	ALDOA ALDA	LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075	S360	Sugiyama	ALDOA ALDA	QGKytPsGQAGAAAsEsLFVsNHAy________________
P04075	T123	Sugiyama	ALDOA ALDA	GVVGIKVDKGVVPLAGtNGEtttQGLDGLsERCAQYKKDGA
P04075	T37	Sugiyama	ALDOA ALDA	sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04080	T96	Sugiyama	CSTB CST6 STFB	ENKPLtLsNyQTNKAKHDELtyF__________________
P04150	S125	Sugiyama	NR3C1 GRL	PQQGQISLSSGETDLKLLEEsIANLNRstsVPENPKSSAST
P04406	S151	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	FVMGVNHEKYDNSLKIIsNAsCttNCLAPLAKVIHDNFGIV
P04406	S241	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406	S321	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IALNDHFVKLIsWyDNEFGysNRVVDLMAHMAsKE______
P04406	T154	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	GVNHEKYDNSLKIIsNAsCttNCLAPLAKVIHDNFGIVEGL
P04406	T237	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04406	T246	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	GKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKVVKQAS
P04920	S56	Sugiyama	SLC4A2 AE2 EPB3L1 HKB3 MPB3L	DELHRTLGVERFEEILQEAGsRGGEEPGRsYGEEDFEyHRQ
P05198	T284	Sugiyama	EIF2S1 EIF2A	EKRGVFNVQMEPKVVtDtDEtELARQMERLERENAEVDGDD
P05362	S88	Sugiyama	ICAM1	ELLLPGNNRKVYELSNVQEDsQPMCYSNCPDGQSTAKTFLT
P05386	S101	Sugiyama	RPLP1 RRP1	APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386	S104	Sugiyama	RPLP1 RRP1	tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387	S102	Sugiyama	RPLP2 D11S2243E RPP2	PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387	S105	Sugiyama	RPLP2 D11S2243E RPP2	GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05787	S291	Sugiyama	KRT8 CYK8	ANRsRAEAEsMyQIKyEELQsLAGKHGDDLRRTKTEISEMN
P06733	S37	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	NPtVEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRY
P06733	T205	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06733	T41	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	EVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKG
P07195	T18	Sugiyama	LDHB	___MATLKEKLIAPVAEEEAtVPNNKITVVGVGQVGMACAI
P07195	T323	Sugiyama	LDHB	sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07237	S88	Sugiyama	P4HB ERBA2L PDI PDIA1 PO4DB	GKLKAEGSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNG
P07237	T335	Sugiyama	P4HB ERBA2L PDI PDIA1 PO4DB	VRLITLEEEMTKyKPEsEELtAERItEFCHRFLEGKIKPHL
P07237	T462	Sugiyama	P4HB ERBA2L PDI PDIA1 PO4DB	tLKFFPAsADRtVIDyNGERtLDGFKKFLESGGQDGAGDDD
P07355	S127	Sugiyama	ANXA2 ANX2 ANX2L4 CAL1H LPC2D	AQyDAsELKAsMKGLGtDEDsLIEIICsRtNQELQEINRVy
P07355	T123	Sugiyama	ANXA2 ANX2 ANX2L4 CAL1H LPC2D	LKtPAQyDAsELKAsMKGLGtDEDsLIEIICsRtNQELQEI
P07355	T163	Sugiyama	ANXA2 ANX2 ANX2L4 CAL1H LPC2D	INRVyKEMYKtDLEKDIIsDtsGDFRKLMVALAKGRRAEDG
P07437	S75	Sugiyama	TUBB TUBB5 OK/SW-cl.56	tGGKyVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
P07437	T72	Sugiyama	TUBB TUBB5 OK/SW-cl.56	NEAtGGKyVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVF
P07711	S329	Sugiyama	CTSL CTSL1	GGyVKMAKDRRNHCGIAsAAsyPtV________________
P07737	S30	Sugiyama	PFN1	NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07737	S57	Sugiyama	PFN1	GKtFVNITPAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDs
P07737	S85	Sugiyama	PFN1	tLGGQKCsVIRDsLLQDGEFsMDLRtKstGGAPTFNVtVtK
P07737	T65	Sugiyama	PFN1	PAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQDGEFs
P07737	Y60	Sugiyama	PFN1	FVNITPAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQ
P07814	T746	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	NETSAPFKERPtPsLNNNCttsEDsLVLyNRVAVQGDVVRE
P07900	S53	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P07900	S641	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	DNstMGyMAAKKHLEINPDHsIIEtLRQKAEADKNDKSVKD
P07900	T195	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	DTGEPMGRGTKVILHLKEDQtEyLEERRIKEIVKKHSQFIG
P07900	T305	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	IDQEELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLA
P07900	T317	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	WtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08174	T59	Sugiyama	CD55 CR DAF	PPDVPNAQPALEGRTsFPEDtVItyKCEEsFVKIPGEKDsV
P08238	S45	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238	T190	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
P08238	T297	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	IDQEELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLA
P08238	T309	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	WtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08238	T467	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	NRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyIt
P08621	S410	Sugiyama	SNRNP70 RNPU1Z RPU1 SNRP70 U1AP1	DEARGGGGGQDNGLEGLGNDsRDMYMESEGGDGYLAPENGY
P08670	T202	Sugiyama	VIM	IMRLREKLQEEMLQREEAENtLQsFRQDVDNAsLARLDLER
P09104	S37	Sugiyama	ENO2	NPtVEVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRY
P09104	T41	Sugiyama	ENO2	EVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRYLGKG
P09382	S63	Sugiyama	LGALS1	CLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVFPFQPG
P09493	T282	Sugiyama	TPM1 C15orf13 TMSA	AQKLKYKAISEELDHALNDMtsI__________________
P09651	S95	Sugiyama	HNRNPA1 HNRPA1	RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P09972	T123	Sugiyama	ALDOC ALDC	IVVGIKVDKGVVPLAGtDGEtttQGLDGLsERCAQYKKDGA
P0DPH7	S48	Sugiyama	TUBA3C TUBA2	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P0DPH7	S54	Sugiyama	TUBA3C TUBA2	GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
P10809	S70	Sugiyama	HSPD1 HSP60	AVAVTMGPKGRtVIIEQsWGsPKVTKDGVtVAKsIDLKDKY
P11142	T226	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142	T37	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P11142	T64	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	FtDtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQ
P11142	T66	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P11387	S10	Sugiyama	TOP1	___________MsGDHLHNDsQIEADFRLNDsHKHKDKHKD
P13073	S34	Sugiyama	COX4I1 COX4	AISTSVCVRAHESVVKsEDFsLPAyMDRRDHPLPEVAHVKH
P13489	S290	Sugiyama	RNH1 PRI RNH	AKGCGDLCRVLRAKESLKELsLAGNELGDEGARLLCETLLE
P13929	S37	Sugiyama	ENO3	NPtVEVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRY
P13929	T41	Sugiyama	ENO3	EVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRYLGKG
P14314	T115	Sugiyama	PRKCSH G19P1	GVCDCCDGtDEyNsGVICENtCKEKGRKEREsLQQMAEVtR
P14314	T134	Sugiyama	PRKCSH G19P1	NtCKEKGRKEREsLQQMAEVtREGFRLKKILIEDWKKAREE
P14618	S202	Sugiyama	PKM OIP3 PK2 PK3 PKM2	SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs
P14625	S106	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625	S64	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	tDDEVVQREEEAIQLDGLNAsQIRELREKSEKFAFQAEVNR
P14649	S87	Sugiyama	MYL6B MLC1SA	EEFKEAFELFDRVGDGKILysQCGDVMRALGQNPtNAEVLK
P14854	S52	Sugiyama	COX6B1 COX6B	QNyLDFHRCQKAMTAKGGDIsVCEWyQRVYQsLCPtsWVTD
P15311	S535	Sugiyama	EZR VIL2	EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15311	S539	Sugiyama	EZR VIL2	TEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNENMR
P15311	T533	Sugiyama	EZR VIL2	NEEKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDII
P15531	S120	Sugiyama	NME1 NDPKA NM23	KPGtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELV
P15531	S122	Sugiyama	NME1 NDPKA NM23	GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P18621	T79	Sugiyama	RPL17	PFRRYNGGVGRCAQAKQWGWtQGRWPKKSAEFLLHMLKNAE
P19105	T159	Sugiyama	MYL12A MLCB MRLC3 RLC	DELyREAPIDKKGNFNyIEFtRILKHGAKDKDD________
P19338	S458	Sugiyama	NCL	TEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKN
P19338	S460	Sugiyama	NCL	ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19338	T583	Sugiyama	NCL	sPNARSQPSKTLFVKGLsEDttEEtLKEsFDGsVRARIVTD
P20042	T31	Sugiyama	EIF2S2 EIF2B	tMsKKKKKKKKPFMLDEEGDtQtEEtQPsETKEVEPEPtED
P20042	T33	Sugiyama	EIF2S2 EIF2B	sKKKKKKKKPFMLDEEGDtQtEEtQPsETKEVEPEPtEDKD
P20042	T36	Sugiyama	EIF2S2 EIF2B	KKKKKKPFMLDEEGDtQtEEtQPsETKEVEPEPtEDKDLEA
P20810	S295	Sugiyama	CAST	QEKKRKVEKDtMsDQALEALsAsLGTRQAEPELDLRsIKEV
P20810	S297	Sugiyama	CAST	KKRKVEKDtMsDQALEALsAsLGTRQAEPELDLRsIKEVDE
P22626	S212	Sugiyama	HNRNPA2B1 HNRPA2B1	EMQEVQssRsGRGGNFGFGDsRGGGGNFGPGPGsNFRGGsD
P23526	T157	Sugiyama	AHCY SAHH	NLIHTKYPQLLPGIRGIsEEtTTGVHNLyKMMANGILKVPA
P23528	T63	Sugiyama	CFL1 CFL	DKKNIILEEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyA
P23528	T70	Sugiyama	CFL1 CFL	EEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyALyDAtyE
P23588	S207	Sugiyama	EIF4B	DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P25205	S704	Sugiyama	MCM3	DQEQKRKRRKTRQPDAKDGDsyDPyDFsDtEEEMPQVHtPK
P25786	T11	Sugiyama	PSMA1 HC2 NU PROS30 PSC2	__________MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQ
P26038	S576	Sugiyama	MSN	YKtLRQIRQGNTKQRIDEFEsM___________________
P26373	T148	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373	T151	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P26639	S522	Sugiyama	TARS1 TARS	PEKFLGDIEVWDQAEKQLENsLNEFGEKWELNsGDGAFyGP
P27348	S145	Sugiyama	YWHAQ	YFRyLAEVACGDDRKQtIDNsQGAyQEAFDIsKKEMQPTHP
P27348	S37	Sugiyama	YWHAQ	ERyDDMAtCMKAVtEQGAELsNEERNLLsVAyKNVVGGRRS
P27797	S214	Sugiyama	CALR CRTC	GsLEDDWDFLPPKKIKDPDAsKPEDWDERAKIDDPtDsKPE
P27797	T34	Sugiyama	CALR CRTC	LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P27816	S643	Sugiyama	MAP4	IsPEtVTGtGKKCsLPAEEDsVLEKLGERKPCNsQPSELSS
P27816	T57	Sugiyama	MAP4	VVGETVGKTDyIPLLDVDEKtGNsESKKKPCsEtsQIEDtP
P29401	T342	Sugiyama	TKT	GQALAKLGHAsDRIIALDGDtKNstFsEIFKKEHPDRFIEC
P29401	T444	Sugiyama	TKT	DGPSQMALEDLAMFRsVPtstVFyPsDGVAtEKAVELAANT
P29692	S162	Sugiyama	EEF1D EF1D	AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P29692	S44	Sugiyama	EEF1D EF1D	RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P29692	S64	Sugiyama	EEF1D EF1D	sVILRDIARARENIQKsLAGssGPGAssGtsGDHGELVVRI
P30040	T62	Sugiyama	ERP29 C12orf8 ERP28	DtVtFyKVIPKSKFVLVKFDtQyPyGEKQDEFKRLAENSAS
P30086	T101	Sugiyama	PEBP1 PBP PEBP	YREWHHFLVVNMKGNDIssGtVLsDyVGsGPPKGtGLHRyV
P30101	T485	Sugiyama	PDIA3 ERP57 ERP60 GRP58	KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P31153	T240	Sugiyama	MAT2A AMS2 MATA2	DALKEKVIKAVVPAKyLDEDtIyHLQPsGRFVIGGPQGDAG
P34931	T39	Sugiyama	HSPA1L	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P34932	S414	Sugiyama	HSPA4 APG2 HSPH2	ITDVVPYPISLRWNsPAEEGssDCEVFSKNHAAPFSKVLTF
P35579	S1308	Sugiyama	MYH9	LLsQsDSKSSKLTKDFsALEsQLQDtQELLQEENRQKLsLs
P35579	S169	Sugiyama	MYH9	HIyAITDtAyRSMMQDREDQsILCTGESGAGKTENTKKVIQ
P35579	S1915	Sugiyama	MYH9	KLQRELEDAtEtADAMNREVssLKNKLRRGDLPFVVPRRMA
P35579	T1151	Sugiyama	MYH9	EKQKRDLGEELEALKtELEDtLDstAAQQELRSKREQEVNI
P35579	T1313	Sugiyama	MYH9	DSKSSKLTKDFsALEsQLQDtQELLQEENRQKLsLstKLKQ
P35579	T1745	Sugiyama	MYH9	RRLEARIAQLEEELEEEQGNtELINDRLKKANLQIDQINtD
P35579	T1827	Sugiyama	MYH9	AsITALEAKIAQLEEQLDNEtKERQAACKQVRRTEKKLKDV
P35579	T1904	Sugiyama	MYH9	EEAQRANAsRRKLQRELEDAtEtADAMNREVssLKNKLRRG
P35579	T1906	Sugiyama	MYH9	AQRANAsRRKLQRELEDAtEtADAMNREVssLKNKLRRGDL
P35580	T1158	Sugiyama	MYH10	EKQKRDLsEELEALKTELEDtLDTTAAQQELRTKREQEVAE
P35580	T1433	Sugiyama	MYH10	LAYDKLEKTKNRLQQELDDLtVDLDHQRQVASNLEKKQKKF
P35580	T1718	Sugiyama	MYH10	SsERARRHAEQERDELADEItNSASGKSALLDEKRRLEARI
P35637	S462	Sugiyama	FUS TLS	NECNQCKAPKPDGPGGGPGGsHMGGNyGDDRRGGRGGYDRG
P35659	S227	Sugiyama	DEK	ERNsSGMARKAKRTKCPEILsDEsssDEDEKKNKEEssDDE
P35659	S231	Sugiyama	DEK	SGMARKAKRTKCPEILsDEsssDEDEKKNKEEssDDEDKEs
P35659	S306	Sugiyama	DEK	DSSTTKKNQNSSKKEsEsEDssDDEPLIKKLKKPPTDEELK
P36954	S73	Sugiyama	POLR2I	IyVNKITHEVDELtQIIADVsQDPTLPRTEDHPCQKCGHKE
P36954	T66	Sugiyama	POLR2I	QEADNSCIyVNKITHEVDELtQIIADVsQDPTLPRTEDHPC
P37802	S185	Sugiyama	TAGLN2 KIAA0120 CDABP0035	NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37802	T180	Sugiyama	TAGLN2 KIAA0120 CDABP0035	RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P38398	S395	Sugiyama	BRCA1 RNF53	LNssIQKVNEWFSRSDELLGsDDsHDGEsESNAKVADVLDV
P38398	S398	Sugiyama	BRCA1 RNF53	sIQKVNEWFSRSDELLGsDDsHDGEsESNAKVADVLDVLNE
P38646	T116	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P39019	Y54	Sugiyama	RPS19	VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P39687	T126	Sugiyama	ANP32A C15orf1 LANP MAPM PHAP1	IEPLKKLENLKsLDLFNCEVtNLNDyRENVFKLLPQLtyLD
P41091	T21	Sugiyama	EIF2S3 EIF2G	MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
P43121	T299	Sugiyama	MCAM MUC18	PPHFSISKQNPstREAEEEttNDNGVLVLEPARKEHSGRYE
P46013	T1972	Sugiyama	MKI67	EDLAGFKELFQtPGHtEEsMtDDKITEVsCKsPQPDPVKtP
P46013	T2093	Sugiyama	MKI67	LEDLAGFKELFQtPDHTEESttDDKTTKIACKsPPPEsMDt
P46013	T896	Sugiyama	MKI67	GRSTEFRNIQKLPVESKSEEtNTEIVECILKRGQKATLLQQ
P46087	S40	Sugiyama	NOP2 NOL1 NSUN1	KQKGAEtELVRFLPAVsDENsKRLsSRARKRAAKRRLGsVE
P46777	S172	Sugiyama	RPL5 MSTP030	RTTTGNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNA
P46777	S224	Sugiyama	RPL5 MSTP030	VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46783	T148	Sugiyama	RPS10	RRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ___
P46937	S382	Sugiyama	YAP1 YAP65	QNPVssPGMsQELRTMttNssDPFLNsGtyHsRDEstDsGL
P46937	S403	Sugiyama	YAP1 YAP65	DPFLNsGtyHsRDEstDsGLsMssysVPRtPDDFLNsVDEM
P47756	T202	Sugiyama	CAPZB	SGsGtMNLGGsLtRQMEKDEtVsDCsPHIANIGRLVEDMEN
P49327	T2215	Sugiyama	FASN FAS	DEAsELACPtPKEDGLAQQQtQLNLRSLLVNPEGPtLMRLN
P49790	S94	Sugiyama	NUP153	EVPRWPENKEDHLVYADEESsNITDGRItPEPAVSNTEEPS
P50395	S396	Sugiyama	GDI2 RABGDIB	IEQKFVsISDLLVPKDLGtEsQIFIsRTyDAttHFEttCDD
P50395	T412	Sugiyama	GDI2 RABGDIB	LGtEsQIFIsRTyDAttHFEttCDDIKNIYKRMtGsEFDFE
P50552	T331	Sugiyama	VASP	EKNstTLPRMKssssVttsEtQPCtPsSSDySDLQRVKQEL
P52272	S633	Sugiyama	HNRNPM HNRPM NAGR1	GGGGAsFDRAIEMERGNFGGsFAGsFGGAGGHAPGVARKAC
P52272	S637	Sugiyama	HNRNPM HNRPM NAGR1	AsFDRAIEMERGNFGGsFAGsFGGAGGHAPGVARKACQIFV
P52948	S683	Sugiyama	NUP98 ADAR2	IAKPIPQtPEsAGNKHsNsNsVDDtIVALNMRAALRNGLEG
P52948	T687	Sugiyama	NUP98 ADAR2	IPQtPEsAGNKHsNsNsVDDtIVALNMRAALRNGLEGssEE
P52948	T822	Sugiyama	NUP98 ADAR2	YLDDNQKPPVGEGLNRKAEVtLDGVWPTDKTSRCLIKsPDR
P53999	S12	Sugiyama	SUB1 PC4 RPO2TC1	_________MPKSKELVsssssGsDsDsEVDKKLKRKKQVA
P54105	S42	Sugiyama	CLNS1A CLCI ICLN	DTEAVLNGKGLGtGtLyIAEsRLSWLDGsGLGFSLEYPTIS
P54652	T229	Sugiyama	HSPA2	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P54652	T38	Sugiyama	HSPA2	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P55196	S1510	Sugiyama	AFDN AF6 MLLT4	IERRDLQyItVsKEELssGDsLsPDPWKRDAKEKLEKQQQM
P60174	S212	Sugiyama	TPI1 TPI	WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60174	T217	Sugiyama	TPI1 TPI	VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60174	T90	Sugiyama	TPI1 TPI	VTNGAFtGEIsPGMIKDCGAtWVVLGHsERRHVFGEsDELI
P60660	S30	Sugiyama	MYL6	AEFKEAFQLFDRtGDGKILysQCGDVMRALGQNPtNAEVLK
P60660	T103	Sugiyama	MYL6	QGtyEDyVEGLRVFDKEGNGtVMGAEIRHVLVtLGEKMTEE
P60660	T22	Sugiyama	MYL6	CDFTEDQTAEFKEAFQLFDRtGDGKILysQCGDVMRALGQN
P60709	S60	Sugiyama	ACTB	HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P60709	T249	Sugiyama	ACTB	tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P60709	Y53	Sugiyama	ACTB	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61247	S236	Sugiyama	RPS3A FTE1 MFTL	KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61353	T33	Sugiyama	RPL27	VLAGRYSGRKAVIVKNIDDGtsDRPysHALVAGIDRyPRKV
P61604	S21	Sugiyama	HSPE1	MAGQAFRKFLPLFDRVLVERsAAETVTKGGIMLPEKSQGKV
P61604	T79	Sugiyama	HSPE1	EIQPVsVKVGDKVLLPEyGGtKVVLDDKDyFLFRDGDILGK
P61978	S401	Sugiyama	HNRNPK HNRPK	GDLGGPIIttQVtIPKDLAGsIIGKGGQRIKQIRHEsGAsI
P61978	S75	Sugiyama	HNRNPK HNRPK	GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981	T31	Sugiyama	YWHAG	ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P62258	S148	Sugiyama	YWHAE	YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62269	S96	Sugiyama	RPS18 D6S218E	QYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLKK
P62277	S12	Sugiyama	RPS13	_________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62495	S295	Sugiyama	ETF1 ERF1 RF1 SUP45L1	LSNVKFIQEKKLIGRyFDEIsQDtGKyCFGVEDTLKALEMG
P62736	S62	Sugiyama	ACTA2 ACTSA ACTVS GIG46	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P62736	T251	Sugiyama	ACTA2 ACTSA ACTVS GIG46	tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P62736	Y55	Sugiyama	ACTA2 ACTSA ACTVS GIG46	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62854	S57	Sugiyama	RPS26	KKFVIRNIVEAAAVRDIsEAsVFDAyVLPKLYVKLHYCVSC
P62857	S39	Sugiyama	RPS28	GRtGsQGQCtQVRVEFMDDtsRsIIRNVKGPVREGDVLtLL
P62857	T38	Sugiyama	RPS28	LGRtGsQGQCtQVRVEFMDDtsRsIIRNVKGPVREGDVLtL
P62857	T57	Sugiyama	RPS28	DtsRsIIRNVKGPVREGDVLtLLEsEREARRLR________
P63220	S68	Sugiyama	RPS21	GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____
P63261	S60	Sugiyama	ACTG1 ACTG	HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P63261	T249	Sugiyama	ACTG1 ACTG	tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P63261	Y53	Sugiyama	ACTG1 ACTG	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267	S61	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P63267	T250	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P63267	Y54	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68032	S62	Sugiyama	ACTC1 ACTC	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68032	T251	Sugiyama	ACTC1 ACTC	tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68032	Y55	Sugiyama	ACTC1 ACTC	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68133	S62	Sugiyama	ACTA1 ACTA	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68133	T251	Sugiyama	ACTA1 ACTA	tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68133	Y55	Sugiyama	ACTA1 ACTA	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68363	S48	Sugiyama	TUBA1B	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P68363	S54	Sugiyama	TUBA1B	GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
P68363	T73	Sugiyama	TUBA1B	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363	T80	Sugiyama	TUBA1B	KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
P68363	Y83	Sugiyama	TUBA1B	PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
P68431	S11	SIGNOR\|EPSD	H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J	__________MARtKQtARKstGGKAPRKQLATKAARKsAP
P84098	S37	Sugiyama	RPL19	CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
P84098	T29	Sugiyama	RPL19	RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
Q01082	S2115	Sugiyama	SPTBN1 SPTB2	ERKRRPPsPEPstKVsEEAEsQQQWDtsKGEQVsQNGLPAE
Q01082	S35	Sugiyama	SPTBN1 SPTB2	QQQYSDVNNRWDVDDWDNENsSARLFERSRIKALADEREAV
Q01105	S133	Sugiyama	SET	DEEALHYLTRVEVtEFEDIKsGyRIDFyFDENPyFENKVLS
Q01105	S161	Sugiyama	SET	FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q01105	S165	Sugiyama	SET	PyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQ
Q02952	T577	Sugiyama	AKAP12 AKAP250	sQEEQKGEssAssPEEPEEItCLEKGLAEVQQDGEAEEGAt
Q04721	T132	Sugiyama	NOTCH2	SRPCLNGGTCHMLSRDtyECtCQVGFTGKECQWTDACLSHP
Q04760	T112	Sugiyama	GLO1	ALSRKATLELTHNWGtEDDEtQsyHNGNsDPRGFGHIGIAV
Q05682	S129	Sugiyama	CALD1 CAD CDM	KRLQEALERQKEFDPtItDAsLsLPsRRMQNDTAENETTEK
Q05682	S131	Sugiyama	CALD1 CAD CDM	LQEALERQKEFDPtItDAsLsLPsRRMQNDTAENETTEKEE
Q05682	T86	Sugiyama	CALD1 CAD CDM	VEVNAQNsVPDEEAKTTtTNtQVEGDDEAAFLERLARREER
Q07021	S210	Sugiyama	C1QBP GC1QBP HABP1 SF2P32	EDEVGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDS
Q07157	S1064	Sugiyama	TJP1 ZO1	PYVEKQAsRDLEQPtyRyEsssytDQFsRNYEHRLRYEDRV
Q07157	S1680	Sugiyama	TJP1 ZO1	QGAIPEGVEQEIYFKVCRDNsILPPLDKEKGETLLSPLVMC
Q09666	S1170	Sugiyama	AHNAK PM227	LPKADVVVSGPKVDIEAPDVsLEGPEGKLKGPKFKMPEMHF
Q09666	T146	Sugiyama	AHNAK PM227	ttKIKPRLKsEDGVEGDLGEtQsRTITVTRRVtAytVDVTG
Q09666	T38	Sugiyama	AHNAK PM227	sGsHGLTIAQRDDGVFVQEVtQNsPAARTGVVKEGDQIVGA
Q12805	T219	Sugiyama	EFEMP1 FBLN3 FBNL	CQCPPGYQKRGEQCVDIDECtIPPYCHQRCVNTPGSFYCQC
Q13155	S48	Sugiyama	AIMP2 JTV1 PRO0992	PNVHGRSyGPAPGAGHVQEEsNLsLQALESRQDDILKRLYE
Q13242	T177	Sugiyama	SRSF9 SFRS9 SRP30C	DMEYALRKLDDTKFRsHEGEtsYIRVYPERstsYGYsRsRS
Q13263	S501	Sugiyama	TRIM28 KAP1 RNF96 TIF1B	LMRKVPRVsLERLDLDLtADsQPPVFKVFPGsttEDyNLIV
Q13283	T241	Sugiyama	G3BP1 G3BP	ETAPEDAQKsssPAPADIAQtVQEDLRtFsWAsVtsKNLPP
Q13442	S63	Sugiyama	PDAP1 HASPP28	GGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGVEGLIDI
Q13509	S75	Sugiyama	TUBB3 TUBB4	SSHKYVPRAILVDLEPGtMDsVRSGAFGHLFRPDNFIFGQS
Q13509	T72	Sugiyama	TUBB3 TUBB4	NEASSHKYVPRAILVDLEPGtMDsVRSGAFGHLFRPDNFIF
Q13541	S112	Sugiyama	EIF4EBP1	EAsQsHLRNsPEDKRAGGEEsQFEMDI______________
Q13596	S229	Sugiyama	SNX1	PPPPEKSLIGMTKVKVGKEDsssAEFLEKRRAALERYLQRI
Q13765	S132	Sugiyama	NACA HSD48	YKSPAsDtyIVFGEAKIEDLsQQAQLAAAEKFKVQGEAVsN
Q13885	S75	Sugiyama	TUBB2A TUBB2	AGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q13885	T72	Sugiyama	TUBB2A TUBB2	NEAAGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVF
Q14151	S207	Sugiyama	SAFB2 KIAA0138	FKNtLEtssLNFKVtPDIEEsLLEPENEKILDILGEtCKsE
Q14152	T1378	Sugiyama	EIF3A EIF3S10 KIAA0139	AEKDREsLRRTKNEtDEDGWttVRR________________
Q14157	S855	Sugiyama	UBAP2L KIAA0144 NICE4	ysIPFPtPttPLtGRDGsLAsNPysGDLtKFGRGDASSPAP
Q14157	T256	Sugiyama	UBAP2L KIAA0144 NICE4	AWRtAtEEWGtEDWNEDLsEtKIFtAsNVssVPLPAENVtI
Q14157	T863	Sugiyama	UBAP2L KIAA0144 NICE4	ttPLtGRDGsLAsNPysGDLtKFGRGDASSPAPATTLAQPQ
Q14247	S331	Sugiyama	CTTN EMS1	GVQKDRMDKNAstFEDVtQVssAyQKTVPVEAVtsKtsNIR
Q14247	T328	Sugiyama	CTTN EMS1	GKyGVQKDRMDKNAstFEDVtQVssAyQKTVPVEAVtsKts
Q14257	T137	Sugiyama	RCN2 ERC55	VTWDEyNIQMyDRVIDFDENtALDDAEEEsFRKLHLKDKKR
Q14444	T103	Sugiyama	CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105	NKGERLNQDQLDAVsKyQEVtNNLEFAKELQRsFMALsQDI
Q14444	T303	Sugiyama	CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105	YTEQSEVESTEYVNRQFMAEtQFtsGEKEQVDEWTVETVEV
Q14498	S336	Sugiyama	RBM39 HCC1 RNPC2	LAGRPMKVGHVTERtDAssAssFLDsDELERtGIDLGtTGR
Q14568	S53	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14671	S180	Sugiyama	PUM1 KIAA0099 PUMH1	KDGPKGIFLGDQWRDsAWGTsDHsVsQPIMVQRRPGQsFHV
Q14671	S185	Sugiyama	PUM1 KIAA0099 PUMH1	GIFLGDQWRDsAWGTsDHsVsQPIMVQRRPGQsFHVNsEVN
Q14676	S498	Sugiyama	MDC1 KIAA0170 NFBD1	RALVRAHsEKDQPPFGDsDDsVEADKssPGIHLERsQAstt
Q14676	S763	Sugiyama	MDC1 KIAA0170 NFBD1	LDEPWEVLATQPFCLREsEDsEtQPFDtHLEAyGPCLsPPR
Q14676	T765	Sugiyama	MDC1 KIAA0170 NFBD1	EPWEVLATQPFCLREsEDsEtQPFDtHLEAyGPCLsPPRAI
Q14677	S166	Sugiyama	CLINT1 ENTH EPN4 EPNR KIAA0171	REERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSKWDE
Q14978	S637	Sugiyama	NOLC1 KIAA0035 NS5ATP13	GEKRAssPFRRVREEEIEVDsRVADNsFDAKRGAAGDWGER
Q14978	S643	Sugiyama	NOLC1 KIAA0035 NS5ATP13	sPFRRVREEEIEVDsRVADNsFDAKRGAAGDWGERANQVLK
Q14980	S1181	Sugiyama	NUMA1 NMP22 NUMA	DsALEtLQGQLEEKAQELGHsQsALAsAQRELAAFRTKVQD
Q15047	S86	Sugiyama	SETDB1 ESET KIAA0067 KMT1E	TWVIQKESEVAHVDQLFDDAsRAVTNCEsLVKDFYSKLGLQ
Q15056	S110	Sugiyama	EIF4H KIAA0038 WBSCR1 WSCR1	DEVDsLKEALtyDGALLGDRsLRVDIAEGRKQDKGGFGFRK
Q15056	T100	Sugiyama	EIF4H KIAA0038 WBSCR1 WSCR1	KFKGFCyVEFDEVDsLKEALtyDGALLGDRsLRVDIAEGRK
Q15080	S67	Sugiyama	NCF4 SH3PXD4	TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15084	T166	Sugiyama	PDIA6 ERP5 P5 TXNDC7	YSSGKQGRSDsSSKKDVIELtDDsFDKNVLDSEDVWMVEFY
Q15185	S118	Sugiyama	PTGES3 P23 TEBP	WLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGDEDVDL
Q15185	S72	Sugiyama	PTGES3 P23 TEBP	EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE
Q15185	S82	Sugiyama	PTGES3 P23 TEBP	NDsKHKRtDRsILCCLRKGEsGQsWPRLTKERAKLNWLsVD
Q15293	S158	Sugiyama	RCN1 RCN	EEyKQAtyGyyLGNPAEFHDssDHHtFKKMLPRDERRFKAA
Q15293	S69	Sugiyama	RCN1 RCN	PPEDNQsFQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVD
Q15293	S80	Sugiyama	RCN1 RCN	HEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGDGFVt
Q15293	T318	Sugiyama	RCN1 RCN	EKLTKEEILENWNMFVGsQAtNyGEDLtKNHDEL_______
Q15293	T325	Sugiyama	RCN1 RCN	ILENWNMFVGsQAtNyGEDLtKNHDEL______________
Q15293	T71	Sugiyama	RCN1 RCN	EDNQsFQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVDRI
Q15459	S690	Sugiyama	SF3A1 SAP114	VHPPPPMEDEPTSKKLKTEDsLMPEEEFLRRNKGPVSIKVQ
Q15527	T184	Sugiyama	SURF2	DDsMtDLYPPELFTRKDLGstEDGDGtDDFLtDKEDEKAKP
Q15650	S341	Sugiyama	TRIP4 RQT4	RLSKKVTIDFAGRKILEEENsLAEyHSRLDETIQAIANGTL
Q15652	T513	Sugiyama	JMJD1C JHDM2C KIAA1380 TRIP8	LLPKEKFVSRPPtPKCVIDItNDtNLEKVAQENSSTFGLQT
Q15652	T516	Sugiyama	JMJD1C JHDM2C KIAA1380 TRIP8	KEKFVSRPPtPKCVIDItNDtNLEKVAQENSSTFGLQTLQK
Q16513	S19	Sugiyama	PKN2 PRK2 PRKCL2	__MAsNPERGEILLTELQGDsRsLPFSENVsAVQKLDFsDt
Q16513	S591	Sugiyama	PKN2 PRK2 PRKCL2	EPEPPPAPPRAssLGEIDEssELRVLDIPGQDsEtVFDIQN
Q16513	T605	Sugiyama	PKN2 PRK2 PRKCL2	GEIDEssELRVLDIPGQDsEtVFDIQNDRNsILPKsQsEyK
Q16513	T951	Sugiyama	PKN2 PRK2 PRKCL2	PPFIPTIRGREDVSNFDDEFtsEAPILtPPREPRILsEEEQ
Q16513	T958	Sugiyama	PKN2 PRK2 PRKCL2	RGREDVSNFDDEFtsEAPILtPPREPRILsEEEQEMFRDFD
Q16531	T1137	Sugiyama	DDB1 XAP1	GSGMKREAtADDLIKVVEELtRIH_________________
Q16576	T10	Sugiyama	RBBP7 RBAP46	___________MAsKEMFEDtVEERVINEEYKIWKKNTPFL
Q2VIR3	T21	Sugiyama	EIF2S3B	MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
Q32MZ4	T477	Sugiyama	LRRFIP1 GCF2 TRIP	MVEVPQELEtstGHsLEKEFtNQEAAEPKEVPAHsTEVGRD
Q32P51	S95	Sugiyama	HNRNPA1L2 HNRNPA1L	TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q3ZCM7	S75	Sugiyama	TUBB8	SGGRYVPRAVLVDLEPGtMDsVRSGPFGQVFRPDNFIFGQC
Q3ZCM7	T72	Sugiyama	TUBB8	NEASGGRYVPRAVLVDLEPGtMDsVRSGPFGQVFRPDNFIF
Q4V328	S666	Sugiyama	GRIPAP1 KIAA1167	EELVLsEMNsPSRtQtGDsssIssFsYREILREKEssAVPA
Q562R1	T250	Sugiyama	ACTBL2	RAAAssSPERsyELPDGQVItIGNERFRCPEAIFQPSFLGI
Q58FF6	T165	Sugiyama	HSP90AB4P	DHGEPIDRDTKVILHLKEDQtEyLEERWVKEVVKKHPQFIG
Q58FF7	T169	Sugiyama	HSP90AB3P HSP90BC	DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
Q5JSH3	S71	Sugiyama	WDR44 RPH11	PVQELKQDVSKKIIEsIIEEsQKVLQLEDDsLDSKGKELsD
Q5JSH3	S81	Sugiyama	WDR44 RPH11	KKIIEsIIEEsQKVLQLEDDsLDSKGKELsDQAtAsPIVAR
Q5QJE6	T241	Sugiyama	DNTTIP2 ERBP TDIF2	IVPGNEKQIVGtPVNsEDsDtRQtsHLQARsLsEINKPNFY
Q5QJE6	T244	Sugiyama	DNTTIP2 ERBP TDIF2	GNEKQIVGtPVNsEDsDtRQtsHLQARsLsEINKPNFYNND
Q5RKV6	S14	Sugiyama	EXOSC6 MTR3	_______MPGDHRRIRGPEEsQPPQLyAADEEEAPGTRDPT
Q5T200	S1382	Sugiyama	ZC3H13 KIAA0853	LIsDsVERDRDRDRDRTFESsQIEsVKRCEAKLEGEHERDL
Q5UIP0	S1810	Sugiyama	RIF1	EHHsVNFHLGLKEDNDtINDsLIVSETKSKENTMQEsLPSG
Q5UIP0	T1806	Sugiyama	RIF1	QFLDEHHsVNFHLGLKEDNDtINDsLIVSETKSKENTMQEs
Q5VTR2	S138	Sugiyama	RNF20 BRE1A	GDLLTERKALVVPEPEPDsDsNQERKDDRERGEGQEPAFSF
Q6FI81	T250	Sugiyama	CIAPIN1 CUA001 PRO0915	ASLRAASCGEGKKRKACKNCtCGLAEELEKEKSREQMSSQP
Q6P996	S721	Sugiyama	PDXDC1 KIAA0251	LPGQKPFKRsLRGsDALsEtssVsHIEDLEKVERLssGPEQ
Q6P996	S722	Sugiyama	PDXDC1 KIAA0251	PGQKPFKRsLRGsDALsEtssVsHIEDLEKVERLssGPEQI
Q6P996	S779	Sugiyama	PDXDC1 KIAA0251	QHtDQtEAFQKGVPHPEDDHsQVEGPEsLR___________
Q6PEY2	S48	Sugiyama	TUBA3E	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q6PEY2	S54	Sugiyama	TUBA3E	GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q6S8J3	T949	Sugiyama	POTEE A26C1A POTE2	tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q6UXH1	S295	Sugiyama	CRELD2 UNQ185/PRO211	KECISGYAREHGQCADVDECsLAEKtCVRKNENCYNTPGSY
Q71U36	S48	Sugiyama	TUBA1A TUBA3	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q71U36	S54	Sugiyama	TUBA1A TUBA3	GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q71U36	T73	Sugiyama	TUBA1A TUBA3	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36	T80	Sugiyama	TUBA1A TUBA3	KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q71U36	Y83	Sugiyama	TUBA1A TUBA3	PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q7LBC6	S314	Sugiyama	KDM3B C5orf7 JHDM2B JMJD1B KIAA1082	GCDPASKKLKGDRGEVDsNGsDGGEAsRGPWKGGNASGEPG
Q7LBC6	S320	Sugiyama	KDM3B C5orf7 JHDM2B JMJD1B KIAA1082	KKLKGDRGEVDsNGsDGGEAsRGPWKGGNASGEPGLDQRAK
Q7Z3K3	S28	Sugiyama	POGZ KIAA0461 SUHW5 ZNF280E ZNF635 Nbla00003	MECEEEELEPWQKISDVIEDsVVEDyNsVDKTTTVSVSQQP
Q7Z3T8	S319	Sugiyama	ZFYVE16 KIAA0305	TSALTCSLPKNEDLCLNDsNsRDENFKLPDFsFQEDKTVIK
Q7Z417	S608	Sugiyama	NUFIP2 KIAA1321 PIG1	sGALsLEPsHIGDLQKADtssQGALVFLSKDYEIEsQNPLA
Q7Z417	S652	Sugiyama	NUFIP2 KIAA1321 PIG1	NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z417	T117	Sugiyama	NUFIP2 KIAA1321 PIG1	LNGNAGEREISLKNLssDEAtNPIsRVLNGNQQVVDTsLKQ
Q7Z417	T606	Sugiyama	NUFIP2 KIAA1321 PIG1	sEsGALsLEPsHIGDLQKADtssQGALVFLSKDYEIEsQNP
Q86SQ0	S719	Sugiyama	PHLDB2 LL5B	SMREQLQQQLKRDADLLDVEsKHFEDLEFQQLEHESRLDEE
Q86TU7	S505	Sugiyama	SETD3 C14orf154	NREYYRQQMEEKAPLPKyEEsNLGLLEssVGDSRLPLVLRN
Q86UE4	S323	Sugiyama	MTDH AEG1 LYRIC	KWNsVsPAsAGKRKtEPSAWsQDtGDANtNGKDWGRsWsDR
Q86UE4	T326	Sugiyama	MTDH AEG1 LYRIC	sVsPAsAGKRKtEPSAWsQDtGDANtNGKDWGRsWsDRsIF
Q86UE4	T331	Sugiyama	MTDH AEG1 LYRIC	sAGKRKtEPSAWsQDtGDANtNGKDWGRsWsDRsIFsGIGs
Q86UE8	S686	Sugiyama	TLK2	SVGVIFYQCLYGRKPFGHNQsQQDILQENtILKATEVQFPP
Q86UE8	T695	Sugiyama	TLK2	LYGRKPFGHNQsQQDILQENtILKATEVQFPPKPVVTPEAK
Q86V81	S145	Sugiyama	ALYREF ALY BEF THOC4	LFAEFGtLKKAAVHYDRsGRsLGtADVHFERKADALKAMKQ
Q86V81	S8	Sugiyama	ALYREF ALY BEF THOC4	_____________MADKMDMsLDDIIKLNRSQRGGRGGGRG
Q8IUD2	S824	Sugiyama	ERC1 ELKS KIAA1081 RAB6IP2	KKKsAQMLEEARRREDNLNDsSQQLQDSLRKKDDRIEELEE
Q8IW41	S160	SIGNOR\|PSP	MAPKAPK5 PRAK	HLLNIAHRDLKPENLLFKDNsLDAPVKLCDFGFAKIDQGDL
Q8IW41	S354	SIGNOR\|PSP	MAPKAPK5 PRAK	AEQLANMRIQDLKVSLKPLHsVNNPILRKRKLLGTKPKDSV
Q8IW41	S386	SIGNOR\|PSP	MAPKAPK5 PRAK	LGTKPKDSVYIHDHENGAEDsNVALEKLRDVIAQCILPQAG
Q8N1G0	S316	Sugiyama	ZNF687 KIAA1441	KSSPGsPQSPSSGAEAADEDsNDSPASSSSRPLKVRIKTIK
Q8N6T3	T291	Sugiyama	ARFGAP1 ARF1GAP	GVsQLAsKVQGVGSKGWRDVttFFsGKAEGPLDsPSEGHSy
Q8N6T3	T354	Sugiyama	ARFGAP1 ARF1GAP	SAEPTKtRKsPssDsWtCADtstERRssDsWEVWGSASTNR
Q8NE71	S595	Sugiyama	ABCF1 ABC50	TKEALTRKQQKCRRKNQDEEsQEAPELLKRPKEYTVRFTFP
Q8NEF9	S279	Sugiyama	SRFBP1	EYFDDstEERFYKQSsMSEDsDsGDDFFIGKVRRTRKKESS
Q8NEM2	S42	Sugiyama	SHCBP1	GWAVEQELASLEKGLFQDEDsCsDCsYRDKPGssLQSFMPE
Q8TAM6	S280	Sugiyama	ERMN KIAA1189	TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8TEW0	S840	Sugiyama	PARD3 PAR3 PAR3A	REGFGRQsMsEKRtKQFsDAsQLDFVKTRKsKsMDLGIADE
Q8WU90	T348	Sugiyama	ZC3H15 DFRP1 LEREPO4 HSPC303 HT010 MSTP012 PP730	sVNDIDLSLYIPRDVDEtGItVAsLERFSTYTsDKDENKLs
Q8WUA2	S425	Sugiyama	PPIL4	KNTNQDIYREMGFGHYEEEEsCWEKQKSEKRDRTQNRSRSR
Q8WUD4	S149	Sugiyama	CCDC12	KRTQRAIAELIRERLKGQEDsLAsAVDAATEQKtCDsD___
Q8WVC0	S72	Sugiyama	LEO1 RDL	DSGQPSNKELFGDDsEDEGAsHHsGSDNHSERSDNRsEAsE
Q8WWI1	S1177	Sugiyama	LMO7 FBX20 FBXO20 KIAA0858	SESLQSSNIESKEINGIHDEsNAFEsKASEsISLKNLKRRs
Q8WWI1	S1410	Sugiyama	LMO7 FBX20 FBXO20 KIAA0858	RIYQYRRPVDsyDIPKTEEAsSGFLPGDRNKsRsttELDDY
Q8WWM7	S563	Sugiyama	ATXN2L A2D A2LG A2LP A2RP	EELRKFGAQFKLQPsssPENsLDPFPPRILKEEPKGKEKEV
Q92688	T126	Sugiyama	ANP32B APRIL PHAPI2	LEPLKKLECLKsLDLFNCEVtNLNDyREsVFKLLPQLTYLD
Q92785	S142	Sugiyama	DPF2 BAF45D REQ UBID4	LLRTDPLEKRGAPDPRVDDDsLGEFPVTNsRARKRILEPDD
Q92974	S953	Sugiyama	ARHGEF2 KIAA0651 LFP40	PEERLQDssDPDtGsEEEGssRLsPPHsPRDFtRMQDIPEE
Q92974	S976	Sugiyama	ARHGEF2 KIAA0651 LFP40	sPPHsPRDFtRMQDIPEEtEsRDGEAVASES__________
Q969U7	S166	Sugiyama	PSMG2 HCCA3 PAC2 TNFSF5IP1	SMQKSVQNKIKSLNWEEMEKsRCIPEIDDSEFCIRIPGGGI
Q96AY4	T2170	Sugiyama	TTC28 KIAA1043 TPRBK	QEESNPKLDPQELAQKILEEtQSHLIAVERLQRSGGQVSKS
Q96B36	T233	Sugiyama	AKT1S1 PRAS40	PDLDRIAAsMRALVLREAEDtQVFGDLPRPRLNtsDFQKLK
Q96CT7	S122	Sugiyama	CCDC124	DtLRRDHQLREAPDTAEKAKsHLEVPLEENVNRRVLEEGsV
Q96G46	T82	Sugiyama	DUS3L	PAGNELAEPEAKRIRLEDGQtADGQtEEAAEPGEQLQtQKR
Q96HE7	S143	Sugiyama	ERO1A ERO1L UNQ434/PRO865	EANNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSD
Q96HE7	T148	Sugiyama	ERO1A ERO1L UNQ434/PRO865	IEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSDNFCEA
Q96PY6	S14	EPSD\|PSP	NEK1 KIAA1901	_______MEKYVRLQKIGEGsFGKAILVKstEDGRQYVIKE
Q96PY6	T141	SIGNOR\|EPSD\|PSP	NEK1 KIAA1901	DRKILHRDIKSQNIFLTKDGtVQLGDFGIARVLNstVELAR
Q96PY6	Y315	EPSD\|PSP	NEK1 KIAA1901	sGQNsISVMPAQKITKPAAKyGIPLAyKKYGDKKLHEKKPL
Q99638	S328	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	RAD9A	IAMETTIGNEGSRVLPsIsLsPGPQPPKsPGPHsEEEDEAE
Q99638	T355	SIGNOR\|EPSD\|PSP	RAD9A	KsPGPHsEEEDEAEPStVPGtPPPKKFRsLFFGsILAPVRs
Q99832	T351	Sugiyama	CCT7 CCTH NIP7-1	QtSVNALSADVLGRCQVFEEtQIGGERyNFFtGCPKAKTCt
Q9BQE3	S439	Sugiyama	TUBA1C TUBA6	SEAREDMAALEKDyEEVGADsADGEDEGEEy__________
Q9BQE3	S48	Sugiyama	TUBA1C TUBA6	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9BQE3	S54	Sugiyama	TUBA1C TUBA6	GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q9BQE3	T73	Sugiyama	TUBA1C TUBA6	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3	T80	Sugiyama	TUBA1C TUBA6	KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q9BQE3	Y83	Sugiyama	TUBA1C TUBA6	PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q9BRK5	T193	Sugiyama	SDF4 CAB45 PSEC0034	SEKEVADAIRLNEELKVDEEtQEVLENLKDRWYQADsPPAD
Q9BRQ0	S349	Sugiyama	PYGO2 PP7910	PCGACRSEVNDDQDAILCEAsCQKWFHRECTGMTESAYGLL
Q9BRS2	S21	Sugiyama	RIOK1 RIO1	MDYRRLLMSRVVPGQFDDADssDsENRDLKTVKEKDDILFE
Q9BSJ8	S1086	Sugiyama	ESYT1 FAM62A KIAA0747 MBC2	MsRERELLGKVQLDLAETDLsQGVARWYDLMDNKDKGss__
Q9BVA1	S75	Sugiyama	TUBB2B	tGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q9BVA1	T72	Sugiyama	TUBB2B	NEAtGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVF
Q9BY43	T98	Sugiyama	CHMP4A C14orf123 SHAX2 CDA04 HSPC134	QTDGtLStLEFQREAIENATtNAEVLRTMELAAQSMKKAYQ
Q9BYW2	S968	Sugiyama	SETD2 HIF1 HYPB KIAA1732 KMT3A SET2 HSPC069	NRRNNGLSGKCLQEAQEEGNsILPERRGRPEISLDERGEGG
Q9BYX7	T249	Sugiyama	POTEKP ACTBL3 FKSG30	MAASSSSVEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q9C086	S127	Sugiyama	INO80B HMGA1L4 PAPA1 ZNHIT4	EEEPMEGVPLEQYRAWLDEDsNLsPsPLRDLsGGLGGQEEE
Q9C0C2	S1046	Sugiyama	TNKS1BP1 KIAA1741 TAB182	GLFsPstAHVPDGALGQRDQssWQNsDAsQEVGGHQERQQA
Q9C0C2	S1054	Sugiyama	TNKS1BP1 KIAA1741 TAB182	HVPDGALGQRDQssWQNsDAsQEVGGHQERQQAGAQGPGsA
Q9C0C2	S1331	Sugiyama	TNKS1BP1 KIAA1741 TAB182	WGNNLGLRDLEVtCDPDsGGsQGLRGCGVGQMDWTQDLAPQ
Q9C0C2	S1371	Sugiyama	TNKS1BP1 KIAA1741 TAB182	QNVELFGAPSEAREHGVGGVsQCPEPGLRHNGsLsPGLEAR
Q9C0C2	S806	Sugiyama	TNKS1BP1 KIAA1741 TAB182	STREWASRCGIGQEEMEAsSsQDQSKVSAPGVLTAQDRVVG
Q9C0C2	S882	Sugiyama	TNKS1BP1 KIAA1741 TAB182	LQDQEFGKRDsLGtyssRDVsLGDWEFGKRDsLGAyAsQDA
Q9C0C2	S936	Sugiyama	TNKS1BP1 KIAA1741 TAB182	GRyssQDADEQDWEFQKRDVsLGTyGSRAAEPQEQEFGKSA
Q9C0C2	T1228	Sugiyama	TNKS1BP1 KIAA1741 TAB182	CLESGGSEEPGGIGVGEKDWtsDVNVKSKDLAEVGEGGGHs
Q9C0C2	T1323	Sugiyama	TNKS1BP1 KIAA1741 TAB182	ELGVGQMDWGNNLGLRDLEVtCDPDsGGsQGLRGCGVGQMD
Q9GZV5	S296	Sugiyama	WWTR1 TAZ	QAAVNPPTMtPDMRSItNNssDPFLNGGPyHsREQsTDsGL
Q9H3Q1	T314	Sugiyama	CDC42EP4 BORG4 CEP4	GsARSMGSHTTRDSSsLssCtsGILEERsPAFRGPDRARAA
Q9H425	T300	Sugiyama	C1orf198	PsQLEGKLPsPDVRQDDGEDtLFSEPKFAQVSSSNVVLKTG
Q9H444	T101	Sugiyama	CHMP4B C20orf178 SHAX1	QIDGtLstIEFQREALENANtNtEVLKNMGYAAKAMKAAHD
Q9H4L7	S239	Sugiyama	SMARCAD1 KIAA1122	EDEFNDDQSIKKtRLDHGEEsNEsAEsSsNWEKQESIVLKL
Q9H501	S79	Sugiyama	ESF1 ABTAP C20orf6 HDCMC28P	PISHSTTEDLKRFyDLsDsDsNLsGEDSKALSQKKIKKKKT
Q9H788	S159	Sugiyama	SH2D4A PPP1R38 SH2A	NQQtKDIWKKVAEKEELEQGsRPAPTLEEEKIRSLSSSSRN
Q9H814	T49	Sugiyama	PHAX RNUXA	LQLPKVLGGDsAMRAFQNTAtACAPVSHyRAVESVDSSEES
Q9H8T0	S237	PSP	AKTIP FTS	VKVCTARLFDQPKIEDPYAIsFSPWNPSVHDEAREKMLTQK
Q9H8T0	T22	PSP	AKTIP FTS	NPFWSMSTSsVRKRSEGEEKtLTGDVKtsPPRTAPKKQLPS
Q9NP61	S374	Sugiyama	ARFGAP3 ARFGAP1	SSYFDEPVELRsssFssWDDssDSyWKKETSKDTETVLKTT
Q9NP81	S184	Sugiyama	SARS2 SARSM	YLQALKLPNQTHPDVPVGDEsQARVLHMVGDKPVFSFQPRG
Q9NQ39	T159	Sugiyama	RPS10P5 RPS10L	RRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ___
Q9NRX4	T119	Sugiyama	PHPT1 PHP14 CGI-202 HSPC141	PAQHAISTEKIKAKyPDyEVtWANDGy______________
Q9NS15	S871	Sugiyama	LTBP3	LCPQGHRLVGGRKCQDIDECsQDPSLCLPHGACKNLQGSYV
Q9NUU7	T73	Sugiyama	DDX19A DDX19L	EDRAAQsLLNKLIRSNLVDNtNQVEVLQRDPNsPLysVKsF
Q9NW75	T235	Sugiyama	GPATCH2 GPATC2	KIIRQGPKIQDEGVVLESEEtNQTNKDKMECEEQKVSDELM
Q9NXG6	S485	Sugiyama	P4HTM PH4	ARQALFQQEMARLAREGGtDsQPEWALDRAYRDARVEL___
Q9NYF8	S198	Sugiyama	BCLAF1 BTF KIAA0164	PLKsKsQEEPKDtFEHDPsEsIDEFNKssAtsGDIWPGLsA
Q9NYF8	S345	Sugiyama	BCLAF1 BTF KIAA0164	GGDQETAKtGKFLKRFtDEEsRVFLLDRGNtRDKEASKEKG
Q9NYF8	T208	Sugiyama	BCLAF1 BTF KIAA0164	KDtFEHDPsEsIDEFNKssAtsGDIWPGLsAyDNsPRsPHs
Q9NZ53	T603	Sugiyama	PODXL2 UNQ1861/PRO3742	WGALMGGKRDPEDsDVFEEDtHL__________________
Q9P2E9	T1120	Sugiyama	RRBP1 KIAA1398	PPAPAEPSSDLASKLREAEEtQstLQAECDQYRSILAETEG
Q9P2E9	T1306	Sugiyama	RRBP1 KIAA1398	DPVQLKTQLEWTEAILEDEQtQRQKLTAEFEEAQTsACRLQ
Q9UI15	S185	Sugiyama	TAGLN3 NP25	EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UKI8	S147	Sugiyama	TLK1 KIAA0137	AENQNEssQGKSIGGRGHKIsDyFEYQGGNGssPVRGIPPA
Q9UKI8	S158	Sugiyama	TLK1 KIAA0137	SIGGRGHKIsDyFEYQGGNGssPVRGIPPAIRsPQNsHsHs
Q9UKI8	S159	Sugiyama	TLK1 KIAA0137	IGGRGHKIsDyFEYQGGNGssPVRGIPPAIRsPQNsHsHst
Q9UKI8	S226	Sugiyama	TLK1 KIAA0137	QLSFKIIQTDLTMLKLAALEsNKIQDLEKKEGRIDDLLRAN
Q9UKI8	S54	Sugiyama	TLK1 KIAA0137	LLNHtPPsGRPREGAMDELHsLDPRRQELLEARFTGVAsGs
Q9UKI8	S679	Sugiyama	TLK1 KIAA0137	SVGVIFFQCLYGRKPFGHNQsQQDILQENtILKATEVQFPV
Q9UKI8	T688	Sugiyama	TLK1 KIAA0137	LYGRKPFGHNQsQQDILQENtILKATEVQFPVKPVVSSEAK
Q9UKV3	S661	Sugiyama	ACIN1 ACINUS KIAA0670	SRSRSRSASSNSRKsLsPGVsRDsstsytEtKDPssGQEVA
Q9UKV3	Y668	Sugiyama	ACIN1 ACINUS KIAA0670	ASSNSRKsLsPGVsRDsstsytEtKDPssGQEVAtPPVPQL
Q9UMR2	T74	Sugiyama	DDX19B DBP5 DDX19 TDBP	EDRAAQsLLNKLIRSNLVDNtNQVEVLQRDPNsPLysVKsF
Q9UMX5	T76	Sugiyama	NENF CIR2 SPUF	GGEEEDQPIyLAVKGVVFDVtSGKEFYGRGAPYNALTGKDS
Q9UPQ0	S201	Sugiyama	LIMCH1 KIAA1102	DCWDsERsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVV
Q9UQ35	S2459	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	LLPPAQDQPRsPVPsAFsDQsRCLIAQTTPVAGSQSLSSGA
Q9Y2B0	S116	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	IDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKFA
Q9Y2B0	S63	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	AQVDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLE
Q9Y2B0	S65	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2T3	S49	Sugiyama	GDA KIAA1258	LRDHLLGVSDSGKIVFLEEAsQQEKLAKEWCFKPCEIRELS
Q9Y2W1	S217	Sugiyama	THRAP3 BCLAF2 TRAP150	QGDEAKEQtFsGGtsQDTKAsEssKPWPDAtyGtGsAsRAs
Q9Y2W1	S234	Sugiyama	THRAP3 BCLAF2 TRAP150	TKAsEssKPWPDAtyGtGsAsRAsAVsELsPRERsPALKsP
Q9Y2X3	S434	Sugiyama	NOP58 NOL5 NOP5 HSPC120	AKTEKYEHKSEVKtyDPSGDstLPtCsKKRKIEQVDKEDEI
Q9Y2X7	T601	Sugiyama	GIT1	sRHtsKLsRHGsGADsDyENtQSGDPLLGLEGKRFLELGKE
Q9Y3U8	S91	Sugiyama	RPL36	KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Q9Y450	S65	Sugiyama	HBS1L HBS1 KIAA1038	RDKPsVEPVEEyDyEDLKEssNsVsNHQLSGFDQARLYsCL
Q9Y450	S67	Sugiyama	HBS1L HBS1 KIAA1038	KPsVEPVEEyDyEDLKEssNsVsNHQLSGFDQARLYsCLDH
Q9Y4L1	S742	Sugiyama	HYOU1 GRP170 HSPH4 ORP150	KLQDLTLRDLEKQEREKAANsLEAFIFEtQDKLyQPEyQEV
Q9Y4L1	T750	Sugiyama	HYOU1 GRP170 HSPH4 ORP150	DLEKQEREKAANsLEAFIFEtQDKLyQPEyQEVsTEEQREE
Q9Y4X5	S514	Sugiyama	ARIH1 ARI MOP6 UBCH7BP HUSSY-27	NQADLENATEVLSGYLERDIsQDsLQDIKQKVQDKYRYCES
Q9Y608	S25	Sugiyama	LRRFIP2	ASGRKRTPVKDRFsAEDEALsNIAREAEARLAAKRAARAEA

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Cell Cycle	R-HSA-1640170	2.177003e-11	10.662
Cell Cycle, Mitotic	R-HSA-69278	2.259358e-07	6.646
Chromatin organization	R-HSA-4839726	2.279869e-06	5.642
Apoptotic cleavage of cellular proteins	R-HSA-111465	2.305104e-06	5.637
Cell Cycle Checkpoints	R-HSA-69620	4.667609e-06	5.331
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.082584e-05	4.966
Chromatin modifying enzymes	R-HSA-3247509	1.076549e-05	4.968
Apoptotic execution phase	R-HSA-75153	1.575990e-05	4.802
Cohesin Loading onto Chromatin	R-HSA-2470946	2.545218e-05	4.594
Mitotic Telophase/Cytokinesis	R-HSA-68884	2.678791e-05	4.572
Mitotic Prometaphase	R-HSA-68877	3.692267e-05	4.433
M Phase	R-HSA-68886	5.838851e-05	4.234
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	6.070980e-05	4.217
PKMTs methylate histone lysines	R-HSA-3214841	1.065739e-04	3.972
MITF-M-regulated melanocyte development	R-HSA-9730414	1.756868e-04	3.755
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.783510e-04	3.749
Signaling by ALK in cancer	R-HSA-9700206	1.783510e-04	3.749
Mitotic Metaphase and Anaphase	R-HSA-2555396	2.301972e-04	3.638
Mitotic Anaphase	R-HSA-68882	2.153207e-04	3.667
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	2.474775e-04	3.606
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	2.913906e-04	3.536
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	3.963329e-04	3.402
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	3.910131e-04	3.408
Activation of ATR in response to replication stress	R-HSA-176187	4.196358e-04	3.377
Nuclear Envelope Breakdown	R-HSA-2980766	3.755797e-04	3.425
Nephrin family interactions	R-HSA-373753	5.944922e-04	3.226
MITF-M-dependent gene expression	R-HSA-9856651	6.638155e-04	3.178
Mitotic Spindle Checkpoint	R-HSA-69618	6.616180e-04	3.179
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	7.067514e-04	3.151
Separation of Sister Chromatids	R-HSA-2467813	7.701872e-04	3.113
Smooth Muscle Contraction	R-HSA-445355	7.828165e-04	3.106
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	9.268004e-04	3.033
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	9.449068e-04	3.025
mRNA Splicing - Major Pathway	R-HSA-72163	1.173024e-03	2.931
Epigenetic regulation of gene expression	R-HSA-212165	1.162363e-03	2.935
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	1.557035e-03	2.808
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	1.557035e-03	2.808
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	1.557035e-03	2.808
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	1.557035e-03	2.808
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	1.557035e-03	2.808
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	1.557035e-03	2.808
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	1.557035e-03	2.808
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	1.557035e-03	2.808
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	1.557035e-03	2.808
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	1.557035e-03	2.808
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	1.557035e-03	2.808
Interactions of Rev with host cellular proteins	R-HSA-177243	1.526632e-03	2.816
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.349131e-03	2.870
Signaling by Hippo	R-HSA-2028269	1.648539e-03	2.783
DNA Double-Strand Break Repair	R-HSA-5693532	1.904164e-03	2.720
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	1.950616e-03	2.710
DNA Repair	R-HSA-73894	1.808794e-03	2.743
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	1.800921e-03	2.745
Signaling by ERBB2 ECD mutants	R-HSA-9665348	2.055018e-03	2.687
Ephrin signaling	R-HSA-3928664	2.055018e-03	2.687
Striated Muscle Contraction	R-HSA-390522	2.102365e-03	2.677
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	2.055018e-03	2.687
Developmental Lineages of the Mammary Gland	R-HSA-9924644	2.159202e-03	2.666
mRNA Splicing	R-HSA-72172	2.238296e-03	2.650
Cellular Senescence	R-HSA-2559583	2.308537e-03	2.637
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	2.883097e-03	2.540
Amplification of signal from the kinetochores	R-HSA-141424	2.883097e-03	2.540
ESR-mediated signaling	R-HSA-8939211	3.213522e-03	2.493
G2/M Checkpoints	R-HSA-69481	3.184120e-03	2.497
AURKA Activation by TPX2	R-HSA-8854518	3.462739e-03	2.461
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	3.675088e-03	2.435
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	3.675088e-03	2.435
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	3.599373e-03	2.444
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	4.250472e-03	2.372
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	4.415951e-03	2.355
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	4.550370e-03	2.342
Cell-Cell communication	R-HSA-1500931	5.234795e-03	2.281
EPH-Ephrin signaling	R-HSA-2682334	5.613428e-03	2.251
Interactions of Vpr with host cellular proteins	R-HSA-176033	5.473264e-03	2.262
PI3K/AKT activation	R-HSA-198203	6.438391e-03	2.191
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	7.414493e-03	2.130
Loss of Nlp from mitotic centrosomes	R-HSA-380259	7.414493e-03	2.130
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	7.379015e-03	2.132
VEGFA-VEGFR2 Pathway	R-HSA-4420097	6.932627e-03	2.159
G2/M Transition	R-HSA-69275	6.622312e-03	2.179
Mitotic G2-G2/M phases	R-HSA-453274	7.338828e-03	2.134
S Phase	R-HSA-69242	6.629320e-03	2.179
G2/M DNA damage checkpoint	R-HSA-69473	7.248466e-03	2.140
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	6.942158e-03	2.159
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	7.788411e-03	2.109
Signaling by EGFRvIII in Cancer	R-HSA-5637812	8.376659e-03	2.077
Constitutive Signaling by EGFRvIII	R-HSA-5637810	8.376659e-03	2.077
SWI/SNF chromatin remodelers	R-HSA-9932451	8.522786e-03	2.069
ATP-dependent chromatin remodelers	R-HSA-9932444	8.522786e-03	2.069
Meiotic synapsis	R-HSA-1221632	8.134124e-03	2.090
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	8.655092e-03	2.063
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	8.938646e-03	2.049
Nuclear import of Rev protein	R-HSA-180746	8.938646e-03	2.049
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	1.000432e-02	2.000
Polo-like kinase mediated events	R-HSA-156711	1.000432e-02	2.000
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	9.252521e-03	2.034
Myogenesis	R-HSA-525793	9.849633e-03	2.007
Mitotic Prophase	R-HSA-68875	9.566736e-03	2.019
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	9.696716e-03	2.013
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.009910e-02	1.996
Noncanonical activation of NOTCH3	R-HSA-9017802	1.057485e-02	1.976
Interaction between L1 and Ankyrins	R-HSA-445095	1.131719e-02	1.946
Extra-nuclear estrogen signaling	R-HSA-9009391	1.157331e-02	1.937
Processing of DNA double-strand break ends	R-HSA-5693607	1.270184e-02	1.896
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	1.388434e-02	1.857
snRNP Assembly	R-HSA-191859	1.421034e-02	1.847
Metabolism of non-coding RNA	R-HSA-194441	1.421034e-02	1.847
Signaling by VEGF	R-HSA-194138	1.370806e-02	1.863
Neurofascin interactions	R-HSA-447043	1.445722e-02	1.840
Signaling by ERBB2 KD Mutants	R-HSA-9664565	1.470319e-02	1.833
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.470319e-02	1.833
Impaired BRCA2 binding to RAD51	R-HSA-9709570	1.470319e-02	1.833
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	1.584784e-02	1.800
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.615766e-02	1.792
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.615766e-02	1.792
Signaling by ERBB2	R-HSA-1227986	1.548229e-02	1.810
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.581736e-02	1.801
Signaling by ALK	R-HSA-201556	1.585172e-02	1.800
Transcriptional Regulation by TP53	R-HSA-3700989	1.663087e-02	1.779
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.663537e-02	1.779
Signaling by ERBB2 in Cancer	R-HSA-1227990	1.663537e-02	1.779
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.710842e-02	1.767
Activated NTRK3 signals through PI3K	R-HSA-9603381	1.904426e-02	1.720
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	1.904426e-02	1.720
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.873566e-02	1.727
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.873566e-02	1.727
Centrosome maturation	R-HSA-380287	1.983783e-02	1.703
Homology Directed Repair	R-HSA-5693538	1.818838e-02	1.740
Downstream signal transduction	R-HSA-186763	1.873566e-02	1.727
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	1.866594e-02	1.729
Heme signaling	R-HSA-9707616	1.827411e-02	1.738
ISG15 antiviral mechanism	R-HSA-1169408	1.983783e-02	1.703
PI3K/AKT Signaling in Cancer	R-HSA-2219528	1.818838e-02	1.740
Cation-coupled Chloride cotransporters	R-HSA-426117	1.904426e-02	1.720
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	2.269955e-02	1.644
IPs transport between nucleus and cytosol	R-HSA-1855170	2.346444e-02	1.630
Transport of the SLBP independent Mature mRNA	R-HSA-159227	2.346444e-02	1.630
DCC mediated attractive signaling	R-HSA-418885	2.269955e-02	1.644
Sema3A PAK dependent Axon repulsion	R-HSA-399954	2.269955e-02	1.644
Integrin signaling	R-HSA-354192	2.346444e-02	1.630
Diseases of mitotic cell cycle	R-HSA-9675126	2.101012e-02	1.678
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	2.346444e-02	1.630
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	2.346444e-02	1.630
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization	R-HSA-180897	2.140944e-02	1.669
Signaling by FGFR1 in disease	R-HSA-5655302	2.146878e-02	1.668
FGFR1 mutant receptor activation	R-HSA-1839124	2.346444e-02	1.630
Deubiquitination	R-HSA-5688426	2.304309e-02	1.637
Cellular response to heat stress	R-HSA-3371556	2.149908e-02	1.668
Muscle contraction	R-HSA-397014	2.282376e-02	1.642
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	2.442072e-02	1.612
Regulation of TP53 Activity	R-HSA-5633007	2.455743e-02	1.610
Gene expression (Transcription)	R-HSA-74160	2.506859e-02	1.601
Host Interactions of HIV factors	R-HSA-162909	2.524292e-02	1.598
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	2.610393e-02	1.583
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	2.610393e-02	1.583
Phosphorylation of the APC/C	R-HSA-176412	2.670540e-02	1.573
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	2.670540e-02	1.573
Estrogen-dependent gene expression	R-HSA-9018519	2.734063e-02	1.563
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	2.768174e-02	1.558
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	2.893347e-02	1.539
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	2.893347e-02	1.539
Classical Kir channels	R-HSA-1296053	3.226049e-02	1.491
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	3.092039e-02	1.510
GP1b-IX-V activation signalling	R-HSA-430116	3.035874e-02	1.518
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	3.035874e-02	1.518
Regulated proteolysis of p75NTR	R-HSA-193692	3.035874e-02	1.518
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	3.035874e-02	1.518
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	3.195748e-02	1.495
Unfolded Protein Response (UPR)	R-HSA-381119	3.156829e-02	1.501
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	3.365889e-02	1.473
Diseases of DNA repair	R-HSA-9675135	3.365889e-02	1.473
Signaling by EGFR in Cancer	R-HSA-1643713	3.500065e-02	1.456
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	3.500065e-02	1.456
Regulation of TP53 Degradation	R-HSA-6804757	3.517997e-02	1.454
RET signaling	R-HSA-8853659	3.517997e-02	1.454
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	3.591277e-02	1.445
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	3.591277e-02	1.445
Meiosis	R-HSA-1500620	3.839473e-02	1.416
Vpr-mediated nuclear import of PICs	R-HSA-180910	3.860445e-02	1.413
GAB1 signalosome	R-HSA-180292	4.112187e-02	1.386
Chaperone Mediated Autophagy	R-HSA-9613829	4.112187e-02	1.386
Depolymerization of the Nuclear Lamina	R-HSA-4419969	4.112187e-02	1.386
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	4.223397e-02	1.374
SLC-mediated transport of inorganic anions	R-HSA-9958790	4.223397e-02	1.374
Regulation of gap junction activity	R-HSA-191650	4.480801e-02	1.349
PLCG1 events in ERBB2 signaling	R-HSA-1251932	4.480801e-02	1.349
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	4.449594e-02	1.352
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	4.607110e-02	1.337
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	4.838598e-02	1.315
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	4.480801e-02	1.349
Regulation of TP53 Expression and Degradation	R-HSA-6806003	4.607110e-02	1.337
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	4.692913e-02	1.329
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	4.607110e-02	1.337
HSF1-dependent transactivation	R-HSA-3371571	4.975375e-02	1.303
Signal Transduction	R-HSA-162582	4.841175e-02	1.315
NS1 Mediated Effects on Host Pathways	R-HSA-168276	4.607110e-02	1.337
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	5.011790e-02	1.300
Nuclear signaling by ERBB4	R-HSA-1251985	5.011790e-02	1.300
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	5.258862e-02	1.279
DAP12 signaling	R-HSA-2424491	5.293369e-02	1.276
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	5.293369e-02	1.276
Downregulation of ERBB2 signaling	R-HSA-8863795	5.293369e-02	1.276
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	5.348571e-02	1.272
VEGFR2 mediated vascular permeability	R-HSA-5218920	5.437597e-02	1.265
Resolution of Abasic Sites (AP sites)	R-HSA-73933	5.437597e-02	1.265
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	5.437597e-02	1.265
Oxidative Stress Induced Senescence	R-HSA-2559580	5.536049e-02	1.257
Axon guidance	R-HSA-422475	5.626921e-02	1.250
NrCAM interactions	R-HSA-447038	5.883673e-02	1.230
IRS activation	R-HSA-74713	5.883673e-02	1.230
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	5.883673e-02	1.230
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	5.883673e-02	1.230
Signaling by NTRK1 (TRKA)	R-HSA-187037	6.130871e-02	1.212
Repression of WNT target genes	R-HSA-4641265	6.133611e-02	1.212
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	6.133611e-02	1.212
Signaling by LTK	R-HSA-9842663	6.133611e-02	1.212
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	6.135920e-02	1.212
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	7.414968e-02	1.130
Phosphorylation of Emi1	R-HSA-176417	7.414968e-02	1.130
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	7.071282e-02	1.151
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	6.978261e-02	1.156
Signaling by EGFR	R-HSA-177929	7.002872e-02	1.155
L1CAM interactions	R-HSA-373760	6.423747e-02	1.192
Interleukin-6 signaling	R-HSA-1059683	7.071282e-02	1.151
mTORC1-mediated signalling	R-HSA-166208	7.319214e-02	1.136
TCF dependent signaling in response to WNT	R-HSA-201681	6.448662e-02	1.191
Aryl hydrocarbon receptor signalling	R-HSA-8937144	7.414968e-02	1.130
CDC6 association with the ORC:origin complex	R-HSA-68689	7.414968e-02	1.130
Negative regulation of the PI3K/AKT network	R-HSA-199418	6.669191e-02	1.176
Signaling by NTRK3 (TRKC)	R-HSA-9034015	6.598797e-02	1.181
Cellular responses to stimuli	R-HSA-8953897	7.106793e-02	1.148
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	7.414968e-02	1.130
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	7.319214e-02	1.136
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	7.071282e-02	1.151
Signaling by PDGFR in disease	R-HSA-9671555	6.598797e-02	1.181
Signaling by NOTCH3	R-HSA-9012852	6.563222e-02	1.183
Sodium-coupled phosphate cotransporters	R-HSA-427652	7.414968e-02	1.130
Regulation of CDH19 Expression and Function	R-HSA-9764302	7.414968e-02	1.130
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	6.598797e-02	1.181
Ub-specific processing proteases	R-HSA-5689880	7.601344e-02	1.119
Cell junction organization	R-HSA-446728	7.704680e-02	1.113
Cellular responses to stress	R-HSA-2262752	7.712141e-02	1.113
Platelet Aggregation (Plug Formation)	R-HSA-76009	7.885669e-02	1.103
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	7.933595e-02	1.101
NRIF signals cell death from the nucleus	R-HSA-205043	8.069032e-02	1.093
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	8.077778e-02	1.093
Cilium Assembly	R-HSA-5617833	8.165684e-02	1.088
CREB phosphorylation	R-HSA-199920	9.056684e-02	1.043
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	9.056684e-02	1.043
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	1.023229e-01	0.990
PRC2 methylates histones and DNA	R-HSA-212300	9.500773e-02	1.022
mRNA Splicing - Minor Pathway	R-HSA-72165	8.438852e-02	1.074
Degradation of CDH1	R-HSA-9766229	1.022287e-01	0.990
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	8.932622e-02	1.049
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	8.932622e-02	1.049
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	1.023229e-01	0.990
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	9.056684e-02	1.043
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	8.424605e-02	1.074
Transcriptional regulation by small RNAs	R-HSA-5578749	8.252282e-02	1.083
Viral Messenger RNA Synthesis	R-HSA-168325	9.457543e-02	1.024
HATs acetylate histones	R-HSA-3214847	9.225438e-02	1.035
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.020939e-01	0.991
Nef and signal transduction	R-HSA-164944	9.056684e-02	1.043
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	8.334469e-02	1.079
Metabolism of RNA	R-HSA-8953854	9.708957e-02	1.013
Co-stimulation by CD28	R-HSA-389356	9.607686e-02	1.017
Signaling by FGFR in disease	R-HSA-1226099	9.173811e-02	1.037
Signaling by PDGF	R-HSA-186797	9.999235e-02	1.000
Regulation of NFE2L2 gene expression	R-HSA-9818749	9.056684e-02	1.043
Signaling by NTRKs	R-HSA-166520	8.588454e-02	1.066
Signaling by LTK in cancer	R-HSA-9842640	9.056684e-02	1.043
Signaling by ERBB4	R-HSA-1236394	9.173811e-02	1.037
IRF3-mediated induction of type I IFN	R-HSA-3270619	9.123785e-02	1.040
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	8.820579e-02	1.055
XBP1(S) activates chaperone genes	R-HSA-381038	8.820579e-02	1.055
Interleukin-7 signaling	R-HSA-1266695	9.705511e-02	1.013
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.054323e-01	0.977
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	1.054323e-01	0.977
Diseases of Telomere Maintenance	R-HSA-9673013	1.054323e-01	0.977
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.054323e-01	0.977
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	1.054323e-01	0.977
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.054323e-01	0.977
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.054323e-01	0.977
Semaphorin interactions	R-HSA-373755	1.055754e-01	0.976
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	1.057247e-01	0.976
VLDL clearance	R-HSA-8964046	1.079239e-01	0.967
SOS-mediated signalling	R-HSA-112412	1.079239e-01	0.967
MECP2 regulates transcription factors	R-HSA-9022707	1.079239e-01	0.967
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	1.079239e-01	0.967
Uptake and function of diphtheria toxin	R-HSA-5336415	1.079239e-01	0.967
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	1.079239e-01	0.967
TRAF3-dependent IRF activation pathway	R-HSA-918233	1.139117e-01	0.943
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	1.139117e-01	0.943
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	1.139117e-01	0.943
Nervous system development	R-HSA-9675108	1.141647e-01	0.942
EPHA-mediated growth cone collapse	R-HSA-3928663	1.147318e-01	0.940
IRE1alpha activates chaperones	R-HSA-381070	1.159796e-01	0.936
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	1.168718e-01	0.932
Developmental Cell Lineages	R-HSA-9734767	1.170602e-01	0.932
Intracellular signaling by second messengers	R-HSA-9006925	1.171320e-01	0.931
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	1.539081e-01	0.813
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	1.539081e-01	0.813
Signaling by TCF7L2 mutants	R-HSA-5339700	1.539081e-01	0.813
Defective GFPT1 causes CMSTA1	R-HSA-4085023	1.539081e-01	0.813
TRAF3 deficiency - HSE	R-HSA-5602571	1.539081e-01	0.813
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	1.539081e-01	0.813
EGFR interacts with phospholipase C-gamma	R-HSA-212718	1.260711e-01	0.899
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	1.260711e-01	0.899
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	1.448720e-01	0.839
ALK mutants bind TKIs	R-HSA-9700645	1.448720e-01	0.839
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	1.513502e-01	0.820
Translation initiation complex formation	R-HSA-72649	1.359341e-01	0.867
Ribosomal scanning and start codon recognition	R-HSA-72702	1.507140e-01	0.822
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	1.424394e-01	0.846
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.491189e-01	0.826
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	1.233910e-01	0.909
Regulation of CDH1 Expression and Function	R-HSA-9764265	1.233910e-01	0.909
Activation of the pre-replicative complex	R-HSA-68962	1.436399e-01	0.843
Generation of second messenger molecules	R-HSA-202433	1.248577e-01	0.904
DNA Double Strand Break Response	R-HSA-5693606	1.295273e-01	0.888
Adherens junctions interactions	R-HSA-418990	1.225972e-01	0.912
Cell-cell junction organization	R-HSA-421270	1.282912e-01	0.892
Platelet sensitization by LDL	R-HSA-432142	1.384607e-01	0.859
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	1.436399e-01	0.843
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	1.448720e-01	0.839
HDR through Homologous Recombination (HRR)	R-HSA-5685942	1.295273e-01	0.888
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	1.539081e-01	0.813
Co-stimulation by ICOS	R-HSA-9927354	1.260711e-01	0.899
E2F mediated regulation of DNA replication	R-HSA-113510	1.513502e-01	0.820
Regulation of signaling by CBL	R-HSA-912631	1.513502e-01	0.820
Regulation of TP53 Activity through Methylation	R-HSA-6804760	1.384607e-01	0.859
Attenuation phase	R-HSA-3371568	1.248577e-01	0.904
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.233011e-01	0.909
Breakdown of the nuclear lamina	R-HSA-352238	1.539081e-01	0.813
TGFBR3 PTM regulation	R-HSA-9839383	1.260711e-01	0.899
Organelle biogenesis and maintenance	R-HSA-1852241	1.452190e-01	0.838
Transcriptional regulation by RUNX1	R-HSA-8878171	1.506303e-01	0.822
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	1.448720e-01	0.839
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	1.448720e-01	0.839
Transcriptional Regulation by VENTX	R-HSA-8853884	1.329250e-01	0.876
SARS-CoV-2-host interactions	R-HSA-9705683	1.581521e-01	0.801
Signaling by TGFB family members	R-HSA-9006936	1.282193e-01	0.892
Signaling by TGF-beta Receptor Complex	R-HSA-170834	1.537273e-01	0.813
Respiratory syncytial virus genome replication	R-HSA-9834752	1.448720e-01	0.839
PIP3 activates AKT signaling	R-HSA-1257604	1.186214e-01	0.926
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	1.491189e-01	0.826
Apoptosis	R-HSA-109581	1.362604e-01	0.866
Programmed Cell Death	R-HSA-5357801	1.312542e-01	0.882
Tie2 Signaling	R-HSA-210993	1.384607e-01	0.859
STING mediated induction of host immune responses	R-HSA-1834941	1.513502e-01	0.820
Regulation of CDH1 Function	R-HSA-9764561	1.583627e-01	0.800
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	1.583627e-01	0.800
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	1.997598e-01	0.699
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	1.997598e-01	0.699
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	2.431292e-01	0.614
Activated NTRK3 signals through PLCG1	R-HSA-9034793	2.431292e-01	0.614
PLC-gamma1 signalling	R-HSA-167021	2.431292e-01	0.614
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	2.431292e-01	0.614
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	2.431292e-01	0.614
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	2.431292e-01	0.614
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	2.431292e-01	0.614
Defective ABCC2 causes DJS	R-HSA-5679001	2.431292e-01	0.614
Activated NTRK2 signals through PLCG1	R-HSA-9026527	2.841508e-01	0.546
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine	R-HSA-9735763	2.841508e-01	0.546
Nucleotide catabolism defects	R-HSA-9735786	2.841508e-01	0.546
GRB7 events in ERBB2 signaling	R-HSA-1306955	2.841508e-01	0.546
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.642028e-01	0.785
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	1.642028e-01	0.785
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.839511e-01	0.735
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.839511e-01	0.735
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.839511e-01	0.735
Regulation of MITF-M dependent genes involved in invasion	R-HSA-9854909	3.229513e-01	0.491
Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)	R-HSA-5619067	3.229513e-01	0.491
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	2.040149e-01	0.690
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	2.040149e-01	0.690
Signaling by GSK3beta mutants	R-HSA-5339716	2.040149e-01	0.690
RUNX3 regulates p14-ARF	R-HSA-8951936	2.243023e-01	0.649
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	2.243023e-01	0.649
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	2.243023e-01	0.649
Scavenging by Class F Receptors	R-HSA-3000484	2.243023e-01	0.649
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	2.243023e-01	0.649
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	2.243023e-01	0.649
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	2.243023e-01	0.649
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	2.243023e-01	0.649
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	3.596510e-01	0.444
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	3.596510e-01	0.444
PTK6 Regulates Cell Cycle	R-HSA-8849470	3.596510e-01	0.444
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.646024e-01	0.784
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	1.781821e-01	0.749
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	3.943635e-01	0.404
PTK6 promotes HIF1A stabilization	R-HSA-8857538	3.943635e-01	0.404
VLDL assembly	R-HSA-8866423	3.943635e-01	0.404
Chylomicron clearance	R-HSA-8964026	3.943635e-01	0.404
Erythropoietin activates STAT5	R-HSA-9027283	3.943635e-01	0.404
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	R-HSA-3656244	3.943635e-01	0.404
Defective CHST6 causes MCDC1	R-HSA-3656225	3.943635e-01	0.404
Defective ST3GAL3 causes MCT12 and EIEE15	R-HSA-3656243	3.943635e-01	0.404
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	3.943635e-01	0.404
FGFR2 alternative splicing	R-HSA-6803529	2.061857e-01	0.686
Beta-catenin phosphorylation cascade	R-HSA-196299	2.857166e-01	0.544
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	2.350919e-01	0.629
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	4.271962e-01	0.369
RUNX3 regulates WNT signaling	R-HSA-8951430	4.271962e-01	0.369
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	4.271962e-01	0.369
Recycling of eIF2:GDP	R-HSA-72731	4.271962e-01	0.369
PERK regulates gene expression	R-HSA-381042	2.085664e-01	0.681
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	1.858035e-01	0.731
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	1.952790e-01	0.709
PI3K events in ERBB2 signaling	R-HSA-1963642	3.466194e-01	0.460
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	4.582509e-01	0.339
phospho-PLA2 pathway	R-HSA-111995	4.582509e-01	0.339
Activated NTRK2 signals through PI3K	R-HSA-9028335	4.582509e-01	0.339
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.700087e-01	0.770
Signaling by Erythropoietin	R-HSA-9006335	3.096797e-01	0.509
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	3.862790e-01	0.413
Impaired BRCA2 binding to PALB2	R-HSA-9709603	3.862790e-01	0.413
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	2.249919e-01	0.648
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	2.552226e-01	0.593
Co-inhibition by CTLA4	R-HSA-389513	4.057145e-01	0.392
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	4.057145e-01	0.392
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	4.057145e-01	0.392
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	4.057145e-01	0.392
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	4.057145e-01	0.392
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	2.393651e-01	0.621
Nucleosome assembly	R-HSA-774815	3.420664e-01	0.466
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	3.420664e-01	0.466
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	3.849019e-01	0.415
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	3.545657e-01	0.450
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	4.436557e-01	0.353
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	4.436557e-01	0.353
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	4.436557e-01	0.353
Dual Incision in GG-NER	R-HSA-5696400	3.997728e-01	0.398
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	4.621160e-01	0.335
Formation of RNA Pol II elongation complex	R-HSA-112382	4.291137e-01	0.367
RNA Polymerase II Transcription Elongation	R-HSA-75955	4.413572e-01	0.355
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	4.413572e-01	0.355
Post-translational protein phosphorylation	R-HSA-8957275	4.052550e-01	0.392
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	3.642535e-01	0.439
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	4.775772e-01	0.321
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	4.775772e-01	0.321
Regulation of mitotic cell cycle	R-HSA-453276	4.491216e-01	0.348
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	4.491216e-01	0.348
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	2.447302e-01	0.611
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	1.839511e-01	0.735
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	2.205422e-01	0.657
Telomere Extension By Telomerase	R-HSA-171319	2.946116e-01	0.531
Chromosome Maintenance	R-HSA-73886	3.405057e-01	0.468
Nucleotide Excision Repair	R-HSA-5696398	2.098470e-01	0.678
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	2.646461e-01	0.577
Cap-dependent Translation Initiation	R-HSA-72737	4.373672e-01	0.359
Regulation of endogenous retroelements	R-HSA-9842860	1.839379e-01	0.735
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	2.040149e-01	0.690
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	3.264648e-01	0.486
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	4.248482e-01	0.372
Signaling downstream of RAS mutants	R-HSA-9649948	3.545657e-01	0.450
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	3.545657e-01	0.450
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	3.545657e-01	0.450
G0 and Early G1	R-HSA-1538133	3.549262e-01	0.450
TRAF6 mediated IRF7 activation	R-HSA-933541	2.318375e-01	0.635
Type I hemidesmosome assembly	R-HSA-446107	4.582509e-01	0.339
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	2.061857e-01	0.686
Eukaryotic Translation Initiation	R-HSA-72613	4.373672e-01	0.359
Regulation of CDH11 function	R-HSA-9762292	1.642028e-01	0.785
VxPx cargo-targeting to cilium	R-HSA-5620916	4.057145e-01	0.392
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	2.559011e-01	0.592
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	4.436557e-01	0.353
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	3.997728e-01	0.398
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	3.514497e-01	0.454
EPHB-mediated forward signaling	R-HSA-3928662	3.295793e-01	0.482
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	2.246084e-01	0.649
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	3.596510e-01	0.444
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	3.264648e-01	0.486
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	4.582509e-01	0.339
Degradation of beta-catenin by the destruction complex	R-HSA-195253	4.383882e-01	0.358
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	4.352622e-01	0.361
Activation of HOX genes during differentiation	R-HSA-5619507	2.032348e-01	0.692
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	2.032348e-01	0.692
Oncogenic MAPK signaling	R-HSA-6802957	2.642923e-01	0.578
RUNX3 regulates NOTCH signaling	R-HSA-8941856	2.243023e-01	0.649
Long-term potentiation	R-HSA-9620244	2.498032e-01	0.602
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	2.795915e-01	0.553
Signaling by RAF1 mutants	R-HSA-9656223	2.923286e-01	0.534
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	2.799418e-01	0.553
Cyclin D associated events in G1	R-HSA-69231	3.295793e-01	0.482
G1 Phase	R-HSA-69236	3.295793e-01	0.482
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	1.693662e-01	0.771
Late Phase of HIV Life Cycle	R-HSA-162599	4.010225e-01	0.397
TNFR1-mediated ceramide production	R-HSA-5626978	2.841508e-01	0.546
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	3.229513e-01	0.491
PTK6 Down-Regulation	R-HSA-8849472	3.229513e-01	0.491
Sensing of DNA Double Strand Breaks	R-HSA-5693548	2.040149e-01	0.690
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	2.243023e-01	0.649
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	2.652240e-01	0.576
LDL remodeling	R-HSA-8964041	4.271962e-01	0.369
RAF activation	R-HSA-5673000	1.971948e-01	0.705
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	2.498032e-01	0.602
G protein gated Potassium channels	R-HSA-1296059	2.498032e-01	0.602
Activation of G protein gated Potassium channels	R-HSA-1296041	2.498032e-01	0.602
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	4.582509e-01	0.339
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	2.231918e-01	0.651
Fanconi Anemia Pathway	R-HSA-6783310	3.420664e-01	0.466
Signaling by RAS mutants	R-HSA-6802949	3.545657e-01	0.450
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	3.997728e-01	0.398
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	4.437099e-01	0.353
DNA Replication Pre-Initiation	R-HSA-69002	3.624882e-01	0.441
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	2.678162e-01	0.572
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	2.678162e-01	0.572
Spry regulation of FGF signaling	R-HSA-1295596	2.857166e-01	0.544
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	4.291137e-01	0.367
Signaling by FLT3 fusion proteins	R-HSA-9703465	2.646461e-01	0.577
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	3.596510e-01	0.444
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	3.943635e-01	0.404
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	3.943635e-01	0.404
p38MAPK events	R-HSA-171007	2.857166e-01	0.544
DNA Damage Recognition in GG-NER	R-HSA-5696394	1.860213e-01	0.730
Nuclear RNA decay	R-HSA-9930044	3.699468e-01	0.432
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	2.646461e-01	0.577
Adipogenesis	R-HSA-9843745	4.338616e-01	0.363
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	2.040149e-01	0.690
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	1.860213e-01	0.730
NoRC negatively regulates rRNA expression	R-HSA-427413	2.799418e-01	0.553
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	2.085664e-01	0.681
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	2.049184e-01	0.688
Signaling by WNT in cancer	R-HSA-4791275	3.549262e-01	0.450
Interleukin-6 family signaling	R-HSA-6783589	2.350919e-01	0.629
Golgi-to-ER retrograde transport	R-HSA-8856688	4.416512e-01	0.355
Mitotic G1 phase and G1/S transition	R-HSA-453279	3.096531e-01	0.509
Signal transduction by L1	R-HSA-445144	1.646024e-01	0.784
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	3.873018e-01	0.412
Signaling by SCF-KIT	R-HSA-1433557	3.171178e-01	0.499
Transcriptional regulation by RUNX3	R-HSA-8878159	2.577707e-01	0.589
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	2.349880e-01	0.629
Signaling by WNT	R-HSA-195721	2.450540e-01	0.611
Influenza Virus Induced Apoptosis	R-HSA-168277	1.997598e-01	0.699
MET interacts with TNS proteins	R-HSA-8875513	2.431292e-01	0.614
Signaling by APC mutants	R-HSA-4839744	1.839511e-01	0.735
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	3.229513e-01	0.491
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	2.040149e-01	0.690
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	2.040149e-01	0.690
Signaling by AXIN mutants	R-HSA-4839735	2.040149e-01	0.690
Signaling by AMER1 mutants	R-HSA-4839748	2.040149e-01	0.690
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	3.943635e-01	0.404
G2/M DNA replication checkpoint	R-HSA-69478	3.943635e-01	0.404
Phase 4 - resting membrane potential	R-HSA-5576886	3.061480e-01	0.514
VEGFR2 mediated cell proliferation	R-HSA-5218921	2.498032e-01	0.602
Axonal growth inhibition (RHOA activation)	R-HSA-193634	4.582509e-01	0.339
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	4.436557e-01	0.353
MET promotes cell motility	R-HSA-8875878	4.580798e-01	0.339
Influenza Viral RNA Transcription and Replication	R-HSA-168273	3.713731e-01	0.430
Signaling by Nuclear Receptors	R-HSA-9006931	1.788555e-01	0.747
Oncogene Induced Senescence	R-HSA-2559585	2.085664e-01	0.681
Signaling by FGFR2	R-HSA-5654738	2.231918e-01	0.651
RMTs methylate histone arginines	R-HSA-3214858	3.295793e-01	0.482
MTOR signalling	R-HSA-165159	3.046961e-01	0.516
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	3.862790e-01	0.413
TCR signaling	R-HSA-202403	2.441304e-01	0.612
Autophagy	R-HSA-9612973	3.783381e-01	0.422
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	3.707855e-01	0.431
Signal attenuation	R-HSA-74749	1.642028e-01	0.785
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	4.582509e-01	0.339
Inwardly rectifying K+ channels	R-HSA-1296065	3.549262e-01	0.450
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	3.699468e-01	0.432
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	3.699468e-01	0.432
HSF1 activation	R-HSA-3371511	4.291926e-01	0.367
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	2.835668e-01	0.547
DAP12 interactions	R-HSA-2172127	1.673831e-01	0.776
MyD88-independent TLR4 cascade	R-HSA-166166	3.707855e-01	0.431
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	3.295232e-01	0.482
Adrenoceptors	R-HSA-390696	4.582509e-01	0.339
Signaling by FGFR4	R-HSA-5654743	3.171178e-01	0.499
Response of endothelial cells to shear stress	R-HSA-9860931	3.132317e-01	0.504
HIV Infection	R-HSA-162906	3.060720e-01	0.514
Developmental Biology	R-HSA-1266738	2.097217e-01	0.678
Muscarinic acetylcholine receptors	R-HSA-390648	3.229513e-01	0.491
Signaling by FGFR4 in disease	R-HSA-5655291	2.652240e-01	0.576
MET activates PI3K/AKT signaling	R-HSA-8851907	4.271962e-01	0.369
Regulation of PTEN gene transcription	R-HSA-8943724	1.822768e-01	0.739
Molecules associated with elastic fibres	R-HSA-2129379	3.398604e-01	0.469
HDACs deacetylate histones	R-HSA-3214815	2.761386e-01	0.559
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	2.893945e-01	0.539
Signaling by FGFR3	R-HSA-5654741	3.420664e-01	0.466
Opioid Signalling	R-HSA-111885	4.588448e-01	0.338
Listeria monocytogenes entry into host cells	R-HSA-8876384	1.920546e-01	0.717
Netrin-1 signaling	R-HSA-373752	1.673831e-01	0.776
NGF-stimulated transcription	R-HSA-9031628	2.049184e-01	0.688
PI5P Regulates TP53 Acetylation	R-HSA-6811555	2.447302e-01	0.611
Ca2+ pathway	R-HSA-4086398	4.704203e-01	0.328
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	3.264648e-01	0.486
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	4.167871e-01	0.380
Cellular responses to mechanical stimuli	R-HSA-9855142	2.728435e-01	0.564
Ovarian tumor domain proteases	R-HSA-5689896	4.437099e-01	0.353
Macroautophagy	R-HSA-1632852	3.862901e-01	0.413
Signaling by FGFR1	R-HSA-5654736	4.775772e-01	0.321
HDMs demethylate histones	R-HSA-3214842	2.498032e-01	0.602
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	4.704203e-01	0.328
Platelet activation, signaling and aggregation	R-HSA-76002	3.756670e-01	0.425
LDL clearance	R-HSA-8964038	4.621160e-01	0.335
Signaling by KIT in disease	R-HSA-9669938	2.061857e-01	0.686
Signaling by FGFR	R-HSA-190236	4.052550e-01	0.392
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	2.431292e-01	0.614
Metalloprotease DUBs	R-HSA-5689901	2.646461e-01	0.577
CD28 dependent PI3K/Akt signaling	R-HSA-389357	2.795915e-01	0.553
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	4.582509e-01	0.339
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	4.582509e-01	0.339
Defective pyroptosis	R-HSA-9710421	3.171178e-01	0.499
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	3.096797e-01	0.509
MAP kinase activation	R-HSA-450294	3.405677e-01	0.468
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	1.642028e-01	0.785
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	1.989661e-01	0.701
Uptake and function of anthrax toxins	R-HSA-5210891	3.466194e-01	0.460
Signalling to RAS	R-HSA-167044	4.248482e-01	0.372
Base Excision Repair	R-HSA-73884	3.160368e-01	0.500
Uptake and actions of bacterial toxins	R-HSA-5339562	2.449145e-01	0.611
PECAM1 interactions	R-HSA-210990	1.839511e-01	0.735
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	2.857166e-01	0.544
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	2.857166e-01	0.544
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	2.857166e-01	0.544
DAG and IP3 signaling	R-HSA-1489509	3.420664e-01	0.466
Interleukin-17 signaling	R-HSA-448424	4.383882e-01	0.358
Signaling by PTK6	R-HSA-8848021	3.623481e-01	0.441
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	3.623481e-01	0.441
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	2.857166e-01	0.544
CD209 (DC-SIGN) signaling	R-HSA-5621575	2.350919e-01	0.629
RNA Polymerase II Transcription	R-HSA-73857	1.931926e-01	0.714
Syndecan interactions	R-HSA-3000170	2.205422e-01	0.657
FLT3 signaling through SRC family kinases	R-HSA-9706374	2.841508e-01	0.546
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	1.642028e-01	0.785
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	2.205422e-01	0.657
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	3.061480e-01	0.514
Netrin mediated repulsion signals	R-HSA-418886	4.271962e-01	0.369
TGFBR3 expression	R-HSA-9839394	2.498032e-01	0.602
Sodium/Proton exchangers	R-HSA-425986	4.582509e-01	0.339
FLT3 signaling in disease	R-HSA-9682385	4.291926e-01	0.367
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	4.535216e-01	0.343
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	2.646461e-01	0.577
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	2.727588e-01	0.564
Elastic fibre formation	R-HSA-1566948	4.580798e-01	0.339
Generic Transcription Pathway	R-HSA-212436	2.178039e-01	0.662
Formation of definitive endoderm	R-HSA-9823730	1.646024e-01	0.784
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	3.247706e-01	0.488
AKT phosphorylates targets in the cytosol	R-HSA-198323	2.243023e-01	0.649
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	2.243023e-01	0.649
Synthesis of DNA	R-HSA-69239	3.459528e-01	0.461
SLC-mediated transport of amino acids	R-HSA-9958863	4.059337e-01	0.392
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	3.765873e-01	0.424
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	2.061857e-01	0.686
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	2.061857e-01	0.686
Influenza Infection	R-HSA-168255	3.138597e-01	0.503
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	3.596510e-01	0.444
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	3.596510e-01	0.444
Cell-extracellular matrix interactions	R-HSA-446353	2.857166e-01	0.544
CHL1 interactions	R-HSA-447041	4.271962e-01	0.369
Downregulation of ERBB4 signaling	R-HSA-1253288	4.582509e-01	0.339
FOXO-mediated transcription of cell death genes	R-HSA-9614657	3.665698e-01	0.436
Switching of origins to a post-replicative state	R-HSA-69052	2.989125e-01	0.524
Signaling by MET	R-HSA-6806834	3.667916e-01	0.436
Interleukin-12 family signaling	R-HSA-447115	2.898965e-01	0.538
Signaling by NOTCH2	R-HSA-1980145	1.971948e-01	0.705
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	3.171178e-01	0.499
Transcriptional Regulation by MECP2	R-HSA-8986944	3.248449e-01	0.488
Reproduction	R-HSA-1474165	2.994805e-01	0.524
G1/S-Specific Transcription	R-HSA-69205	4.291926e-01	0.367
FOXO-mediated transcription	R-HSA-9614085	4.142258e-01	0.383
Inositol phosphate metabolism	R-HSA-1483249	2.583585e-01	0.588
Negative regulation of MET activity	R-HSA-6807004	4.057145e-01	0.392
SARS-CoV-1-host interactions	R-HSA-9692914	2.165445e-01	0.664
PI3K Cascade	R-HSA-109704	4.044282e-01	0.393
Interleukin receptor SHC signaling	R-HSA-912526	4.802118e-01	0.319
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	4.437099e-01	0.353
FLT3 Signaling	R-HSA-9607240	2.800302e-01	0.553
Signaling by NTRK2 (TRKB)	R-HSA-9006115	2.795915e-01	0.553
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	3.046961e-01	0.516
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	4.248482e-01	0.372
Transcriptional Regulation by E2F6	R-HSA-8953750	2.557021e-01	0.592
Gene Silencing by RNA	R-HSA-211000	2.233246e-01	0.651
PI Metabolism	R-HSA-1483255	2.971109e-01	0.527
Zinc efflux and compartmentalization by the SLC30 family	R-HSA-435368	3.229513e-01	0.491
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	3.229513e-01	0.491
Growth hormone receptor signaling	R-HSA-982772	2.205422e-01	0.657
Activated NTRK2 signals through FYN	R-HSA-9032500	4.582509e-01	0.339
tRNA processing in the nucleus	R-HSA-6784531	1.989661e-01	0.701
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	4.057145e-01	0.392
Regulation of necroptotic cell death	R-HSA-5675482	3.699468e-01	0.432
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	4.410614e-01	0.356
RIPK1-mediated regulated necrosis	R-HSA-5213460	4.580798e-01	0.339
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	4.775772e-01	0.321
Signaling by TGFBR3	R-HSA-9839373	1.858035e-01	0.731
Glycolysis	R-HSA-70171	4.231867e-01	0.373
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.693662e-01	0.771
Displacement of DNA glycosylase by APEX1	R-HSA-110357	4.271962e-01	0.369
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	3.264648e-01	0.486
Synaptic adhesion-like molecules	R-HSA-8849932	3.665698e-01	0.436
rRNA modification in the nucleus and cytosol	R-HSA-6790901	3.623481e-01	0.441
RUNX2 regulates bone development	R-HSA-8941326	4.291926e-01	0.367
GPVI-mediated activation cascade	R-HSA-114604	4.291926e-01	0.367
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	2.445849e-01	0.612
Insulin processing	R-HSA-264876	2.795915e-01	0.553
Zygotic genome activation (ZGA)	R-HSA-9819196	4.248482e-01	0.372
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	2.152538e-01	0.667
NPAS4 regulates expression of target genes	R-HSA-9768919	1.971948e-01	0.705
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	4.248482e-01	0.372
Miscellaneous transport and binding events	R-HSA-5223345	3.849019e-01	0.415
Signaling by Leptin	R-HSA-2586552	1.642028e-01	0.785
Signal regulatory protein family interactions	R-HSA-391160	2.652240e-01	0.576
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	4.582509e-01	0.339
SARS-CoV-2 Infection	R-HSA-9694516	4.033144e-01	0.394
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	3.623481e-01	0.441
Transcriptional Regulation by NPAS4	R-HSA-9634815	4.291137e-01	0.367
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	4.580798e-01	0.339
SARS-CoV Infections	R-HSA-9679506	4.592845e-01	0.338
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	2.249919e-01	0.648
Diseases of programmed cell death	R-HSA-9645723	4.546448e-01	0.342
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	3.997728e-01	0.398
Interleukin-12 signaling	R-HSA-9020591	3.277896e-01	0.484
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	4.722892e-01	0.326
MAPK family signaling cascades	R-HSA-5683057	4.806779e-01	0.318
Signaling by NOTCH4	R-HSA-9013694	4.809729e-01	0.318
rRNA processing in the nucleus and cytosol	R-HSA-8868773	4.842296e-01	0.315
Inhibition of DNA recombination at telomere	R-HSA-9670095	4.863265e-01	0.313
Aggrephagy	R-HSA-9646399	4.863265e-01	0.313
Regulation of RUNX3 expression and activity	R-HSA-8941858	4.863265e-01	0.313
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	4.876238e-01	0.312
WNT mediated activation of DVL	R-HSA-201688	4.876238e-01	0.312
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	4.876238e-01	0.312
Inactivation of CDC42 and RAC1	R-HSA-428543	4.876238e-01	0.312
p75NTR regulates axonogenesis	R-HSA-193697	4.876238e-01	0.312
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	4.876238e-01	0.312
MAPK1 (ERK2) activation	R-HSA-112411	4.876238e-01	0.312
Unwinding of DNA	R-HSA-176974	4.876238e-01	0.312
MASTL Facilitates Mitotic Progression	R-HSA-2465910	4.876238e-01	0.312
AKT phosphorylates targets in the nucleus	R-HSA-198693	4.876238e-01	0.312
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	4.876238e-01	0.312
Cellular response to mitochondrial stress	R-HSA-9840373	4.876238e-01	0.312
IRS-mediated signalling	R-HSA-112399	4.894515e-01	0.310
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	4.914530e-01	0.309
MAPK1/MAPK3 signaling	R-HSA-5684996	4.943486e-01	0.306
Deadenylation of mRNA	R-HSA-429947	4.979281e-01	0.303
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	4.979281e-01	0.303
Neurodegenerative Diseases	R-HSA-8863678	4.979281e-01	0.303
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	4.979281e-01	0.303
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	5.001807e-01	0.301
Dual incision in TC-NER	R-HSA-6782135	5.012134e-01	0.300
UCH proteinases	R-HSA-5689603	5.018550e-01	0.299
Signaling by NOTCH1	R-HSA-1980143	5.018550e-01	0.299
Signaling by Insulin receptor	R-HSA-74752	5.023223e-01	0.299
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	5.026956e-01	0.299
HIV Life Cycle	R-HSA-162587	5.107195e-01	0.292
Assembly of the pre-replicative complex	R-HSA-68867	5.116874e-01	0.291
Extension of Telomeres	R-HSA-180786	5.128555e-01	0.290
Amino acid transport across the plasma membrane	R-HSA-352230	5.128555e-01	0.290
MAP2K and MAPK activation	R-HSA-5674135	5.138422e-01	0.289
Scavenging by Class A Receptors	R-HSA-3000480	5.138422e-01	0.289
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	5.152530e-01	0.288
Polymerase switching on the C-strand of the telomere	R-HSA-174411	5.152530e-01	0.288
Tight junction interactions	R-HSA-420029	5.152530e-01	0.288
Acyl chain remodelling of PS	R-HSA-1482801	5.152530e-01	0.288
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	5.152530e-01	0.288
Sema4D in semaphorin signaling	R-HSA-400685	5.152530e-01	0.288
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	5.154057e-01	0.288
Folding of actin by CCT/TriC	R-HSA-390450	5.154057e-01	0.288
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	5.154057e-01	0.288
EGFR Transactivation by Gastrin	R-HSA-2179392	5.154057e-01	0.288
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	5.154057e-01	0.288
Interleukin-27 signaling	R-HSA-9020956	5.154057e-01	0.288
Pexophagy	R-HSA-9664873	5.154057e-01	0.288
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	5.154057e-01	0.288
Maturation of spike protein	R-HSA-9683686	5.154057e-01	0.288
MAPK3 (ERK1) activation	R-HSA-110056	5.154057e-01	0.288
Receptor Mediated Mitophagy	R-HSA-8934903	5.154057e-01	0.288
SARS-CoV-1 Infection	R-HSA-9678108	5.174197e-01	0.286
G1/S Transition	R-HSA-69206	5.190816e-01	0.285
Nuclear Receptor transcription pathway	R-HSA-383280	5.224031e-01	0.282
Integrin cell surface interactions	R-HSA-216083	5.224031e-01	0.282
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	5.243714e-01	0.280
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	5.243714e-01	0.280
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	5.243714e-01	0.280
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	5.243714e-01	0.280
Kinesins	R-HSA-983189	5.243714e-01	0.280
Signaling by NOTCH1 in Cancer	R-HSA-2644603	5.243714e-01	0.280
RNA Polymerase I Transcription Initiation	R-HSA-73762	5.273021e-01	0.278
Ca-dependent events	R-HSA-111996	5.273021e-01	0.278
Activation of GABAB receptors	R-HSA-991365	5.273021e-01	0.278
GABA B receptor activation	R-HSA-977444	5.273021e-01	0.278
MET activates PTK2 signaling	R-HSA-8874081	5.321768e-01	0.274
Urea cycle	R-HSA-70635	5.321768e-01	0.274
IRS-related events triggered by IGF1R	R-HSA-2428928	5.357548e-01	0.271
PLC beta mediated events	R-HSA-112043	5.357548e-01	0.271
HCMV Early Events	R-HSA-9609690	5.364466e-01	0.270
ChREBP activates metabolic gene expression	R-HSA-163765	5.416829e-01	0.266
Chylomicron assembly	R-HSA-8963888	5.416829e-01	0.266
Regulation of localization of FOXO transcription factors	R-HSA-9614399	5.416829e-01	0.266
vRNP Assembly	R-HSA-192905	5.416829e-01	0.266
vRNA Synthesis	R-HSA-192814	5.416829e-01	0.266
RHOBTB3 ATPase cycle	R-HSA-9706019	5.416829e-01	0.266
Bicarbonate transporters	R-HSA-425381	5.416829e-01	0.266
Suppression of apoptosis	R-HSA-9635465	5.416829e-01	0.266
CD163 mediating an anti-inflammatory response	R-HSA-9662834	5.416829e-01	0.266
Dissolution of Fibrin Clot	R-HSA-75205	5.416829e-01	0.266
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	5.470000e-01	0.262
NCAM signaling for neurite out-growth	R-HSA-375165	5.470000e-01	0.262
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	5.486922e-01	0.261
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	5.486922e-01	0.261
Signaling by FGFR3 in disease	R-HSA-5655332	5.486922e-01	0.261
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	5.486922e-01	0.261
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	5.486922e-01	0.261
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	R-HSA-83936	5.486922e-01	0.261
RAF/MAP kinase cascade	R-HSA-5673001	5.537048e-01	0.257
Telomere Maintenance	R-HSA-157579	5.574382e-01	0.254
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	5.619414e-01	0.250
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	5.623434e-01	0.250
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	5.647936e-01	0.248
Formation of the Early Elongation Complex	R-HSA-113418	5.647936e-01	0.248
HIV elongation arrest and recovery	R-HSA-167287	5.647936e-01	0.248
Pausing and recovery of HIV elongation	R-HSA-167290	5.647936e-01	0.248
Negative regulation of FGFR3 signaling	R-HSA-5654732	5.647936e-01	0.248
Phase 0 - rapid depolarisation	R-HSA-5576892	5.647936e-01	0.248
Insulin receptor recycling	R-HSA-77387	5.647936e-01	0.248
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	5.647936e-01	0.248
MyD88 cascade initiated on plasma membrane	R-HSA-975871	5.663489e-01	0.247
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	5.663489e-01	0.247
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	5.663489e-01	0.247
Condensation of Prometaphase Chromosomes	R-HSA-2514853	5.665366e-01	0.247
Scavenging by Class H Receptors	R-HSA-3000497	5.665366e-01	0.247
PI3K events in ERBB4 signaling	R-HSA-1250342	5.665366e-01	0.247
NF-kB is activated and signals survival	R-HSA-209560	5.665366e-01	0.247
ERKs are inactivated	R-HSA-202670	5.665366e-01	0.247
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	5.665366e-01	0.247
Activation of RAC1	R-HSA-428540	5.665366e-01	0.247
IGF1R signaling cascade	R-HSA-2428924	5.690552e-01	0.245
Insulin receptor signalling cascade	R-HSA-74751	5.690552e-01	0.245
p75 NTR receptor-mediated signalling	R-HSA-193704	5.751724e-01	0.240
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	5.772240e-01	0.239
Condensation of Prophase Chromosomes	R-HSA-2299718	5.789806e-01	0.237
Regulation of TNFR1 signaling	R-HSA-5357905	5.789806e-01	0.237
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	5.798560e-01	0.237
Late endosomal microautophagy	R-HSA-9615710	5.804774e-01	0.236
DARPP-32 events	R-HSA-180024	5.804774e-01	0.236
DNA methylation	R-HSA-5334118	5.804774e-01	0.236
Negative regulation of FGFR4 signaling	R-HSA-5654733	5.804774e-01	0.236
Downstream signaling of activated FGFR3	R-HSA-5654708	5.804774e-01	0.236
Regulation of CDH11 Expression and Function	R-HSA-9759475	5.804774e-01	0.236
SLC transporter disorders	R-HSA-5619102	5.805408e-01	0.236
IRAK1 recruits IKK complex	R-HSA-937039	5.900441e-01	0.229
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	5.900441e-01	0.229
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	5.900441e-01	0.229
Polymerase switching	R-HSA-69091	5.900441e-01	0.229
Leading Strand Synthesis	R-HSA-69109	5.900441e-01	0.229
p75NTR recruits signalling complexes	R-HSA-209543	5.900441e-01	0.229
GRB2 events in EGFR signaling	R-HSA-179812	5.900441e-01	0.229
Role of second messengers in netrin-1 signaling	R-HSA-418890	5.900441e-01	0.229
Serotonin clearance from the synaptic cleft	R-HSA-380615	5.900441e-01	0.229
Interleukin-35 Signalling	R-HSA-8984722	5.900441e-01	0.229
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	5.900441e-01	0.229
Trafficking and processing of endosomal TLR	R-HSA-1679131	5.900441e-01	0.229
Regulation of IFNG signaling	R-HSA-877312	5.900441e-01	0.229
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	5.900441e-01	0.229
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	5.900441e-01	0.229
Protein-protein interactions at synapses	R-HSA-6794362	5.911585e-01	0.228
Recycling pathway of L1	R-HSA-437239	5.913311e-01	0.228
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	5.913311e-01	0.228
Potential therapeutics for SARS	R-HSA-9679191	5.914248e-01	0.228
Mitochondrial biogenesis	R-HSA-1592230	5.943248e-01	0.226
Rab regulation of trafficking	R-HSA-9007101	5.943248e-01	0.226
Glucose metabolism	R-HSA-70326	5.943248e-01	0.226
Downstream signaling of activated FGFR4	R-HSA-5654716	5.957415e-01	0.225
Interleukin-37 signaling	R-HSA-9008059	5.957415e-01	0.225
G-protein mediated events	R-HSA-112040	6.009840e-01	0.221
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	6.100524e-01	0.215
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	6.100524e-01	0.215
EGFR downregulation	R-HSA-182971	6.105853e-01	0.214
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	6.105853e-01	0.214
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	6.105853e-01	0.214
Trafficking of AMPA receptors	R-HSA-399719	6.105853e-01	0.214
Evasion by RSV of host interferon responses	R-HSA-9833109	6.105853e-01	0.214
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	6.113045e-01	0.214
Chylomicron remodeling	R-HSA-8963901	6.122780e-01	0.213
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	6.122780e-01	0.213
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	6.122780e-01	0.213
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	6.122780e-01	0.213
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	6.122780e-01	0.213
Diseases of nucleotide metabolism	R-HSA-9735804	6.122780e-01	0.213
IL-6-type cytokine receptor ligand interactions	R-HSA-6788467	6.122780e-01	0.213
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	6.122780e-01	0.213
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	6.122780e-01	0.213
CD28 dependent Vav1 pathway	R-HSA-389359	6.122780e-01	0.213
DNA Replication	R-HSA-69306	6.122942e-01	0.213
DNA Damage Bypass	R-HSA-73893	6.153190e-01	0.211
Post NMDA receptor activation events	R-HSA-438064	6.188971e-01	0.208
Death Receptor Signaling	R-HSA-73887	6.191296e-01	0.208
Toll-like Receptor Cascades	R-HSA-168898	6.215409e-01	0.207
DNA strand elongation	R-HSA-69190	6.250095e-01	0.204
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	6.250095e-01	0.204
PPARA activates gene expression	R-HSA-1989781	6.259022e-01	0.203
RSV-host interactions	R-HSA-9833110	6.261355e-01	0.203
Regulation of RAS by GAPs	R-HSA-5658442	6.269507e-01	0.203
Signaling by FGFR2 in disease	R-HSA-5655253	6.269507e-01	0.203
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	6.276736e-01	0.202
Selective autophagy	R-HSA-9663891	6.278917e-01	0.202
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	6.330202e-01	0.199
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	6.330202e-01	0.199
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	6.333073e-01	0.198
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	6.333073e-01	0.198
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	6.333073e-01	0.198
Regulation of KIT signaling	R-HSA-1433559	6.333073e-01	0.198
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	6.333073e-01	0.198
Hydrolysis of LPC	R-HSA-1483115	6.333073e-01	0.198
cGMP effects	R-HSA-418457	6.333073e-01	0.198
Glycerophospholipid catabolism	R-HSA-6814848	6.333073e-01	0.198
Acyl chain remodeling of CL	R-HSA-1482798	6.333073e-01	0.198
Zinc transporters	R-HSA-435354	6.333073e-01	0.198
Assembly of the ORC complex at the origin of replication	R-HSA-68616	6.390159e-01	0.194
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	6.390159e-01	0.194
Negative regulation of FGFR1 signaling	R-HSA-5654726	6.390159e-01	0.194
Regulation of MECP2 expression and activity	R-HSA-9022692	6.390159e-01	0.194
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	6.390159e-01	0.194
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	6.390159e-01	0.194
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	6.390159e-01	0.194
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	6.392541e-01	0.194
ECM proteoglycans	R-HSA-3000178	6.412586e-01	0.193
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	6.494795e-01	0.187
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	6.494795e-01	0.187
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	6.509004e-01	0.186
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	6.509004e-01	0.186
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	6.526074e-01	0.185
Resolution of D-Loop Structures	R-HSA-5693537	6.526074e-01	0.185
Erythropoietin activates RAS	R-HSA-9027284	6.531972e-01	0.185
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	6.531972e-01	0.185
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	6.531972e-01	0.185
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	6.531972e-01	0.185
SHC1 events in EGFR signaling	R-HSA-180336	6.531972e-01	0.185
RNA Polymerase III Chain Elongation	R-HSA-73780	6.531972e-01	0.185
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	6.531972e-01	0.185
G beta:gamma signalling through BTK	R-HSA-8964315	6.531972e-01	0.185
ERBB2 Regulates Cell Motility	R-HSA-6785631	6.531972e-01	0.185
Translesion synthesis by REV1	R-HSA-110312	6.531972e-01	0.185
Telomere C-strand synthesis initiation	R-HSA-174430	6.531972e-01	0.185
p75NTR signals via NF-kB	R-HSA-193639	6.531972e-01	0.185
Activation of BAD and translocation to mitochondria	R-HSA-111447	6.531972e-01	0.185
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	6.531972e-01	0.185
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	6.531972e-01	0.185
Protein methylation	R-HSA-8876725	6.531972e-01	0.185
DNA Damage Reversal	R-HSA-73942	6.531972e-01	0.185
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	6.580716e-01	0.182
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	6.580716e-01	0.182
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	6.603744e-01	0.180
MyD88 dependent cascade initiated on endosome	R-HSA-975155	6.657855e-01	0.177
Negative regulation of FGFR2 signaling	R-HSA-5654727	6.657878e-01	0.177
Calnexin/calreticulin cycle	R-HSA-901042	6.657878e-01	0.177
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	6.657878e-01	0.177
Signal amplification	R-HSA-392518	6.657878e-01	0.177
RNA Polymerase II Pre-transcription Events	R-HSA-674695	6.696604e-01	0.174
Membrane Trafficking	R-HSA-199991	6.709143e-01	0.173
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	6.720095e-01	0.173
Translesion synthesis by POLI	R-HSA-5656121	6.720095e-01	0.173
Killing mechanisms	R-HSA-9664420	6.720095e-01	0.173
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	6.720095e-01	0.173
Activation of SMO	R-HSA-5635838	6.720095e-01	0.173
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	6.720095e-01	0.173
Induction of Cell-Cell Fusion	R-HSA-9733458	6.720095e-01	0.173
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	6.720095e-01	0.173
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	6.720095e-01	0.173
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	6.720095e-01	0.173
Regulation of NF-kappa B signaling	R-HSA-9758274	6.720095e-01	0.173
Atorvastatin ADME	R-HSA-9754706	6.720095e-01	0.173
Clathrin-mediated endocytosis	R-HSA-8856828	6.735478e-01	0.172
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	6.748240e-01	0.171
Platelet degranulation	R-HSA-114608	6.765611e-01	0.170
Downstream signaling of activated FGFR2	R-HSA-5654696	6.785618e-01	0.168
Downstream signaling of activated FGFR1	R-HSA-5654687	6.785618e-01	0.168
Signalling to ERKs	R-HSA-187687	6.785618e-01	0.168
Protein ubiquitination	R-HSA-8852135	6.787764e-01	0.168
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	6.790847e-01	0.168
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	6.814229e-01	0.167
Translesion synthesis by POLK	R-HSA-5655862	6.898023e-01	0.161
Scavenging by Class B Receptors	R-HSA-3000471	6.898023e-01	0.161
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	6.898023e-01	0.161
Processing of Intronless Pre-mRNAs	R-HSA-77595	6.898023e-01	0.161
GRB2 events in ERBB2 signaling	R-HSA-1963640	6.898023e-01	0.161
Transcriptional regulation of testis differentiation	R-HSA-9690406	6.898023e-01	0.161
Synthesis of PG	R-HSA-1483148	6.898023e-01	0.161
Disorders of Developmental Biology	R-HSA-9675151	6.898023e-01	0.161
Calmodulin induced events	R-HSA-111933	6.909345e-01	0.161
CaM pathway	R-HSA-111997	6.909345e-01	0.161
Ion homeostasis	R-HSA-5578775	6.915772e-01	0.160
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	6.915772e-01	0.160
TNF signaling	R-HSA-75893	6.915772e-01	0.160
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	6.955271e-01	0.158
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	7.066309e-01	0.151
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	7.066309e-01	0.151
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	7.066309e-01	0.151
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	7.066309e-01	0.151
Elevation of cytosolic Ca2+ levels	R-HSA-139853	7.066309e-01	0.151
Regulation of FZD by ubiquitination	R-HSA-4641263	7.066309e-01	0.151
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	7.066309e-01	0.151
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	7.066309e-01	0.151
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	7.069655e-01	0.151
COPI-mediated anterograde transport	R-HSA-6807878	7.104831e-01	0.148
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	7.104831e-01	0.148
Purine salvage	R-HSA-74217	7.145005e-01	0.146
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	7.166432e-01	0.145
Circadian clock	R-HSA-9909396	7.167185e-01	0.145
Signaling by Interleukins	R-HSA-449147	7.176343e-01	0.144
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	7.216990e-01	0.142
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	7.225475e-01	0.141
RNA Polymerase III Transcription Termination	R-HSA-73980	7.225475e-01	0.141
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	7.225475e-01	0.141
Mismatch Repair	R-HSA-5358508	7.225475e-01	0.141
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	7.225475e-01	0.141
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	7.230723e-01	0.141
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	7.257072e-01	0.139
Plasma lipoprotein clearance	R-HSA-8964043	7.257072e-01	0.139
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	7.257072e-01	0.139
RAB geranylgeranylation	R-HSA-8873719	7.297522e-01	0.137
GABA receptor activation	R-HSA-977443	7.297522e-01	0.137
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	7.365394e-01	0.133
HIV Transcription Elongation	R-HSA-167169	7.365394e-01	0.133
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	7.365394e-01	0.133
Formation of Incision Complex in GG-NER	R-HSA-5696395	7.365394e-01	0.133
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	7.365394e-01	0.133
Diseases associated with the TLR signaling cascade	R-HSA-5602358	7.365394e-01	0.133
Diseases of Immune System	R-HSA-5260271	7.365394e-01	0.133
Interleukin-2 family signaling	R-HSA-451927	7.365394e-01	0.133
PI-3K cascade:FGFR3	R-HSA-5654710	7.376015e-01	0.132
Translesion Synthesis by POLH	R-HSA-110320	7.376015e-01	0.132
Signaling by FGFR2 IIIa TM	R-HSA-8851708	7.376015e-01	0.132
IKK complex recruitment mediated by RIP1	R-HSA-937041	7.376015e-01	0.132
Rap1 signalling	R-HSA-392517	7.376015e-01	0.132
The NLRP3 inflammasome	R-HSA-844456	7.376015e-01	0.132
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	7.376015e-01	0.132
Crosslinking of collagen fibrils	R-HSA-2243919	7.376015e-01	0.132
Maturation of nucleoprotein	R-HSA-9694631	7.376015e-01	0.132
rRNA processing	R-HSA-72312	7.451064e-01	0.128
Cytoprotection by HMOX1	R-HSA-9707564	7.453343e-01	0.128
Maturation of spike protein	R-HSA-9694548	7.470045e-01	0.127
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	7.473999e-01	0.126
Transcriptional regulation of granulopoiesis	R-HSA-9616222	7.473999e-01	0.126
Beta-catenin independent WNT signaling	R-HSA-3858494	7.475079e-01	0.126
PI-3K cascade:FGFR4	R-HSA-5654720	7.518396e-01	0.124
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	7.518396e-01	0.124
Formation of ATP by chemiosmotic coupling	R-HSA-163210	7.518396e-01	0.124
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	7.518396e-01	0.124
Keratan sulfate degradation	R-HSA-2022857	7.518396e-01	0.124
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	7.518396e-01	0.124
Acyl chain remodelling of PI	R-HSA-1482922	7.518396e-01	0.124
Synthesis of Ketone Bodies	R-HSA-77111	7.518396e-01	0.124
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	7.534132e-01	0.123
G1/S DNA Damage Checkpoints	R-HSA-69615	7.558722e-01	0.122
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	7.571107e-01	0.121
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	7.571107e-01	0.121
Intra-Golgi traffic	R-HSA-6811438	7.571107e-01	0.121
Negative regulation of MAPK pathway	R-HSA-5675221	7.571107e-01	0.121
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	7.571107e-01	0.121
Cytokine Signaling in Immune system	R-HSA-1280215	7.642290e-01	0.117
Regulation of T cell activation by CD28 family	R-HSA-388841	7.644676e-01	0.117
MyD88 deficiency (TLR2/4)	R-HSA-5602498	7.653058e-01	0.116
G-protein activation	R-HSA-202040	7.653058e-01	0.116
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	7.653058e-01	0.116
PKA-mediated phosphorylation of CREB	R-HSA-111931	7.653058e-01	0.116
Lagging Strand Synthesis	R-HSA-69186	7.653058e-01	0.116
ERK/MAPK targets	R-HSA-198753	7.653058e-01	0.116
Acyl chain remodelling of PG	R-HSA-1482925	7.653058e-01	0.116
Basigin interactions	R-HSA-210991	7.653058e-01	0.116
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	7.666191e-01	0.115
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	7.666191e-01	0.115
Cleavage of the damaged pyrimidine	R-HSA-110329	7.668659e-01	0.115
Depyrimidination	R-HSA-73928	7.668659e-01	0.115
Parasite infection	R-HSA-9664407	7.703762e-01	0.113
Leishmania phagocytosis	R-HSA-9664417	7.703762e-01	0.113
FCGR3A-mediated phagocytosis	R-HSA-9664422	7.703762e-01	0.113
Cellular response to hypoxia	R-HSA-1234174	7.721282e-01	0.112
Maternal to zygotic transition (MZT)	R-HSA-9816359	7.738008e-01	0.111
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	7.758496e-01	0.110
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	7.780421e-01	0.109
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	7.780421e-01	0.109
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	7.780421e-01	0.109
Ribavirin ADME	R-HSA-9755088	7.780421e-01	0.109
Amine ligand-binding receptors	R-HSA-375280	7.853571e-01	0.105
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	7.900880e-01	0.102
PI-3K cascade:FGFR1	R-HSA-5654689	7.900880e-01	0.102
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	7.900880e-01	0.102
Notch-HLH transcription pathway	R-HSA-350054	7.900880e-01	0.102
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	7.900880e-01	0.102
Neurotoxicity of clostridium toxins	R-HSA-168799	7.900880e-01	0.102
Regulation of IFNA/IFNB signaling	R-HSA-912694	7.900880e-01	0.102
RAF-independent MAPK1/3 activation	R-HSA-112409	7.900880e-01	0.102
Cellular hexose transport	R-HSA-189200	7.900880e-01	0.102
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	7.900880e-01	0.102
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	7.908100e-01	0.102
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	7.908100e-01	0.102
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	7.908100e-01	0.102
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	7.948398e-01	0.100
Regulated Necrosis	R-HSA-5218859	7.948398e-01	0.100
Interferon Signaling	R-HSA-913531	8.013578e-01	0.096
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	8.014808e-01	0.096
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	8.014808e-01	0.096
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	8.014808e-01	0.096
Formation of the ureteric bud	R-HSA-9830674	8.014808e-01	0.096
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	8.014808e-01	0.096
Organic anion transport by SLCO transporters	R-HSA-879518	8.014808e-01	0.096
Ketone body metabolism	R-HSA-74182	8.014808e-01	0.096
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	8.025458e-01	0.096
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	8.025458e-01	0.096
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	8.025458e-01	0.096
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	8.089075e-01	0.092
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	8.106732e-01	0.091
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	8.122560e-01	0.090
Plasma lipoprotein assembly	R-HSA-8963898	8.122560e-01	0.090
TRAF6 mediated NF-kB activation	R-HSA-933542	8.122560e-01	0.090
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	8.122560e-01	0.090
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	8.122560e-01	0.090
TNFs bind their physiological receptors	R-HSA-5669034	8.122560e-01	0.090
Hedgehog 'on' state	R-HSA-5632684	8.156308e-01	0.089
Cargo trafficking to the periciliary membrane	R-HSA-5620920	8.156308e-01	0.089
Metal ion SLC transporters	R-HSA-425410	8.185008e-01	0.087
Late SARS-CoV-2 Infection Events	R-HSA-9772573	8.189508e-01	0.087
HCMV Infection	R-HSA-9609646	8.201264e-01	0.086
PI-3K cascade:FGFR2	R-HSA-5654695	8.224469e-01	0.085
MicroRNA (miRNA) biogenesis	R-HSA-203927	8.224469e-01	0.085
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	8.224469e-01	0.085
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	8.260372e-01	0.083
p53-Dependent G1 DNA Damage Response	R-HSA-69563	8.260372e-01	0.083
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	8.260372e-01	0.083
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	8.260372e-01	0.083
Gap junction trafficking and regulation	R-HSA-157858	8.260372e-01	0.083
Cardiac conduction	R-HSA-5576891	8.266701e-01	0.083
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	8.284761e-01	0.082
KEAP1-NFE2L2 pathway	R-HSA-9755511	8.297892e-01	0.081
Mitochondrial protein degradation	R-HSA-9837999	8.302601e-01	0.081
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	8.320852e-01	0.080
TRP channels	R-HSA-3295583	8.320852e-01	0.080
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	8.320852e-01	0.080
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	8.320852e-01	0.080
Sphingolipid catabolism	R-HSA-9845614	8.320852e-01	0.080
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	8.341404e-01	0.079
Non-integrin membrane-ECM interactions	R-HSA-3000171	8.405466e-01	0.075
Formation of a pool of free 40S subunits	R-HSA-72689	8.409755e-01	0.075
Processive synthesis on the C-strand of the telomere	R-HSA-174414	8.412008e-01	0.075
Packaging Of Telomere Ends	R-HSA-171306	8.412008e-01	0.075
RNA Polymerase I Transcription Termination	R-HSA-73863	8.412008e-01	0.075
Cristae formation	R-HSA-8949613	8.412008e-01	0.075
Signaling by BMP	R-HSA-201451	8.412008e-01	0.075
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	8.412008e-01	0.075
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	8.412008e-01	0.075
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	8.412008e-01	0.075
ER Quality Control Compartment (ERQC)	R-HSA-901032	8.412008e-01	0.075
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	8.412008e-01	0.075
Maturation of hRSV A proteins	R-HSA-9828806	8.412008e-01	0.075
RNA Polymerase I Promoter Clearance	R-HSA-73854	8.463018e-01	0.072
mRNA 3'-end processing	R-HSA-72187	8.469840e-01	0.072
Neurexins and neuroligins	R-HSA-6794361	8.469840e-01	0.072
Orc1 removal from chromatin	R-HSA-68949	8.469840e-01	0.072
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	8.498222e-01	0.071
Inflammasomes	R-HSA-622312	8.498222e-01	0.071
Pyrimidine salvage	R-HSA-73614	8.498222e-01	0.071
Translation of Structural Proteins	R-HSA-9694635	8.518756e-01	0.070
Golgi Associated Vesicle Biogenesis	R-HSA-432722	8.534401e-01	0.069
Amino acids regulate mTORC1	R-HSA-9639288	8.534401e-01	0.069
HCMV Late Events	R-HSA-9610379	8.545866e-01	0.068
Parasitic Infection Pathways	R-HSA-9824443	8.552459e-01	0.068
Leishmania infection	R-HSA-9658195	8.552459e-01	0.068
RNA Polymerase I Transcription	R-HSA-73864	8.572724e-01	0.067
mRNA Capping	R-HSA-72086	8.579759e-01	0.067
Termination of translesion DNA synthesis	R-HSA-5656169	8.579759e-01	0.067
Signaling by CSF3 (G-CSF)	R-HSA-9674555	8.579759e-01	0.067
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	8.579759e-01	0.067
Platelet calcium homeostasis	R-HSA-418360	8.579759e-01	0.067
Cellular response to starvation	R-HSA-9711097	8.584208e-01	0.066
Class I MHC mediated antigen processing & presentation	R-HSA-983169	8.589428e-01	0.066
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	8.596468e-01	0.066
Base-Excision Repair, AP Site Formation	R-HSA-73929	8.596468e-01	0.066
Transcriptional regulation by RUNX2	R-HSA-8878166	8.622050e-01	0.064
Sensory processing of sound	R-HSA-9659379	8.624964e-01	0.064
PTEN Regulation	R-HSA-6807070	8.653790e-01	0.063
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	8.656121e-01	0.063
SHC1 events in ERBB2 signaling	R-HSA-1250196	8.656874e-01	0.063
RNA Polymerase III Transcription Initiation	R-HSA-76046	8.656874e-01	0.063
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	8.656874e-01	0.063
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	8.656874e-01	0.063
Neurotransmitter clearance	R-HSA-112311	8.656874e-01	0.063
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.656874e-01	0.063
Activation of BH3-only proteins	R-HSA-114452	8.656874e-01	0.063
PKR-mediated signaling	R-HSA-9833482	8.675516e-01	0.062
Signaling by ROBO receptors	R-HSA-376176	8.692838e-01	0.061
Nuclear events mediated by NFE2L2	R-HSA-9759194	8.704600e-01	0.060
NRAGE signals death through JNK	R-HSA-193648	8.713439e-01	0.060
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	8.729807e-01	0.059
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	8.729807e-01	0.059
Synthesis of PA	R-HSA-1483166	8.768501e-01	0.057
Disorders of transmembrane transporters	R-HSA-5619115	8.772856e-01	0.057
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	8.798783e-01	0.056
Defective B3GALTL causes PpS	R-HSA-5083635	8.864018e-01	0.052
Keratan sulfate biosynthesis	R-HSA-2022854	8.864018e-01	0.052
G-protein beta:gamma signalling	R-HSA-397795	8.864018e-01	0.052
Cardiogenesis	R-HSA-9733709	8.864018e-01	0.052
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	8.864018e-01	0.052
Deadenylation-dependent mRNA decay	R-HSA-429914	8.872154e-01	0.052
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	8.872154e-01	0.052
Regulation of beta-cell development	R-HSA-186712	8.872154e-01	0.052
Post-translational protein modification	R-HSA-597592	8.883821e-01	0.051
MAPK6/MAPK4 signaling	R-HSA-5687128	8.904415e-01	0.050
SLC-mediated transmembrane transport	R-HSA-425407	8.914735e-01	0.050
Effects of PIP2 hydrolysis	R-HSA-114508	8.925713e-01	0.049
Acyl chain remodelling of PC	R-HSA-1482788	8.925713e-01	0.049
Heme degradation	R-HSA-189483	8.925713e-01	0.049
Phospholipid metabolism	R-HSA-1483257	8.926813e-01	0.049
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	8.927539e-01	0.049
Platelet homeostasis	R-HSA-418346	8.939473e-01	0.049
RNA Polymerase II Transcription Termination	R-HSA-73856	8.967670e-01	0.047
Nucleotide salvage	R-HSA-8956321	8.967670e-01	0.047
Regulation of RUNX2 expression and activity	R-HSA-8939902	8.967670e-01	0.047
Formation of paraxial mesoderm	R-HSA-9793380	8.967670e-01	0.047
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	8.983585e-01	0.047
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	8.984062e-01	0.047
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	8.984062e-01	0.047
eNOS activation	R-HSA-203615	8.984062e-01	0.047
NOD1/2 Signaling Pathway	R-HSA-168638	8.984062e-01	0.047
Regulation of TLR by endogenous ligand	R-HSA-5686938	8.984062e-01	0.047
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	8.984062e-01	0.047
Mitophagy	R-HSA-5205647	8.984062e-01	0.047
tRNA processing	R-HSA-72306	9.011448e-01	0.045
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	9.039244e-01	0.044
Regulation of Apoptosis	R-HSA-169911	9.039244e-01	0.044
Acyl chain remodelling of PE	R-HSA-1482839	9.039244e-01	0.044
Regulation of PD-L1(CD274) expression	R-HSA-9909648	9.066345e-01	0.043
Vesicle-mediated transport	R-HSA-5653656	9.082522e-01	0.042
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	9.091433e-01	0.041
RNA Polymerase III Transcription	R-HSA-74158	9.091433e-01	0.041
FGFR2 mutant receptor activation	R-HSA-1839126	9.091433e-01	0.041
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	9.096906e-01	0.041
G alpha (i) signalling events	R-HSA-418594	9.108149e-01	0.041
Downstream TCR signaling	R-HSA-202424	9.131892e-01	0.039
Signaling by NOTCH	R-HSA-157118	9.133291e-01	0.039
Degradation of AXIN	R-HSA-4641257	9.140790e-01	0.039
O-glycosylation of TSR domain-containing proteins	R-HSA-5173214	9.140790e-01	0.039
SIRT1 negatively regulates rRNA expression	R-HSA-427359	9.140790e-01	0.039
Degradation of DVL	R-HSA-4641258	9.140790e-01	0.039
Cleavage of the damaged purine	R-HSA-110331	9.140790e-01	0.039
Collagen chain trimerization	R-HSA-8948216	9.140790e-01	0.039
Metabolism of folate and pterines	R-HSA-196757	9.140790e-01	0.039
Nonsense-Mediated Decay (NMD)	R-HSA-927802	9.140990e-01	0.039
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	9.140990e-01	0.039
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	9.143793e-01	0.039
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.187468e-01	0.037
Depurination	R-HSA-73927	9.187468e-01	0.037
Eukaryotic Translation Elongation	R-HSA-156842	9.228733e-01	0.035
Stabilization of p53	R-HSA-69541	9.231613e-01	0.035
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.231613e-01	0.035
Transcription of the HIV genome	R-HSA-167172	9.245745e-01	0.034
Cellular response to chemical stress	R-HSA-9711123	9.258666e-01	0.033
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.267034e-01	0.033
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	9.273362e-01	0.033
Negative regulation of NOTCH4 signaling	R-HSA-9604323	9.273362e-01	0.033
Role of phospholipids in phagocytosis	R-HSA-2029485	9.282064e-01	0.032
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.282064e-01	0.032
Cyclin E associated events during G1/S transition	R-HSA-69202	9.311186e-01	0.031
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	9.312845e-01	0.031
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	9.312845e-01	0.031
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	9.312845e-01	0.031
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	9.315593e-01	0.031
Peptide hormone metabolism	R-HSA-2980736	9.332389e-01	0.030
Viral Infection Pathways	R-HSA-9824446	9.345576e-01	0.029
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	9.350185e-01	0.029
HIV Transcription Initiation	R-HSA-167161	9.350185e-01	0.029
RNA Polymerase II Transcription Initiation	R-HSA-75953	9.350185e-01	0.029
Degradation of GLI1 by the proteasome	R-HSA-5610780	9.350185e-01	0.029
Degradation of GLI2 by the proteasome	R-HSA-5610783	9.350185e-01	0.029
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.350185e-01	0.029
Translation of Structural Proteins	R-HSA-9683701	9.350185e-01	0.029
CLEC7A (Dectin-1) signaling	R-HSA-5607764	9.368399e-01	0.028
Potassium Channels	R-HSA-1296071	9.368399e-01	0.028
trans-Golgi Network Vesicle Budding	R-HSA-199992	9.371231e-01	0.028
Peptide ligand-binding receptors	R-HSA-375276	9.382202e-01	0.028
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	9.385498e-01	0.028
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.385498e-01	0.028
RNA Polymerase II Promoter Escape	R-HSA-73776	9.418894e-01	0.026
Response of Mtb to phagocytosis	R-HSA-9637690	9.418894e-01	0.026
Transport of vitamins, nucleosides, and related molecules	R-HSA-425397	9.426289e-01	0.026
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	9.450477e-01	0.025
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.452068e-01	0.024
Hedgehog 'off' state	R-HSA-5610787	9.462895e-01	0.024
ABC-family proteins mediated transport	R-HSA-382556	9.462895e-01	0.024
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.480345e-01	0.023
Asymmetric localization of PCP proteins	R-HSA-4608870	9.480345e-01	0.023
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.480345e-01	0.023
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.480345e-01	0.023
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	9.480345e-01	0.023
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	9.480345e-01	0.023
Formation of the cornified envelope	R-HSA-6809371	9.484336e-01	0.023
Regulation of pyruvate metabolism	R-HSA-9861718	9.508592e-01	0.022
ER to Golgi Anterograde Transport	R-HSA-199977	9.519584e-01	0.021
PCP/CE pathway	R-HSA-4086400	9.522949e-01	0.021
G alpha (12/13) signalling events	R-HSA-416482	9.522949e-01	0.021
C-type lectin receptors (CLRs)	R-HSA-5621481	9.529417e-01	0.021
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	9.535305e-01	0.021
Synthesis of PC	R-HSA-1483191	9.535305e-01	0.021
G alpha (q) signalling events	R-HSA-416476	9.540943e-01	0.020
Gastrulation	R-HSA-9758941	9.552070e-01	0.020
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.559472e-01	0.020
Leishmania parasite growth and survival	R-HSA-9664433	9.559472e-01	0.020
Intraflagellar transport	R-HSA-5620924	9.560567e-01	0.020
Plasma lipoprotein remodeling	R-HSA-8963899	9.560567e-01	0.020
GPER1 signaling	R-HSA-9634597	9.560567e-01	0.020
Keratan sulfate/keratin metabolism	R-HSA-1638074	9.584457e-01	0.018
Co-inhibition by PD-1	R-HSA-389948	9.599769e-01	0.018
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.607050e-01	0.017
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.622018e-01	0.017
Adaptive Immune System	R-HSA-1280218	9.625266e-01	0.017
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.628416e-01	0.016
Meiotic recombination	R-HSA-912446	9.628416e-01	0.016
Complex IV assembly	R-HSA-9864848	9.628416e-01	0.016
Cytosolic sulfonation of small molecules	R-HSA-156584	9.628416e-01	0.016
Stimuli-sensing channels	R-HSA-2672351	9.629497e-01	0.016
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	9.639309e-01	0.016
Degradation of the extracellular matrix	R-HSA-1474228	9.646903e-01	0.016
RNA Polymerase I Promoter Escape	R-HSA-73772	9.648622e-01	0.016
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.674846e-01	0.014
Transmission across Chemical Synapses	R-HSA-112315	9.683741e-01	0.014
FCERI mediated MAPK activation	R-HSA-2871796	9.686727e-01	0.014
Chaperonin-mediated protein folding	R-HSA-390466	9.701170e-01	0.013
Paracetamol ADME	R-HSA-9753281	9.702887e-01	0.013
Peptide chain elongation	R-HSA-156902	9.714959e-01	0.013
Intrinsic Pathway for Apoptosis	R-HSA-109606	9.719047e-01	0.012
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.719047e-01	0.012
Ribosome-associated quality control	R-HSA-9948299	9.730821e-01	0.012
TP53 Regulates Metabolic Genes	R-HSA-5628897	9.735533e-01	0.012
Cell surface interactions at the vascular wall	R-HSA-202733	9.743218e-01	0.011
Interferon alpha/beta signaling	R-HSA-909733	9.746556e-01	0.011
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.748780e-01	0.011
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.748780e-01	0.011
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	9.752740e-01	0.011
Pre-NOTCH Transcription and Translation	R-HSA-1912408	9.752740e-01	0.011
Peroxisomal protein import	R-HSA-9033241	9.762447e-01	0.010
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	9.764223e-01	0.010
Protein folding	R-HSA-391251	9.775188e-01	0.010
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.775188e-01	0.010
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.775370e-01	0.010
FCGR activation	R-HSA-2029481	9.785659e-01	0.009
Collagen degradation	R-HSA-1442490	9.787591e-01	0.009
Collagen formation	R-HSA-1474290	9.795658e-01	0.009
Mitochondrial protein import	R-HSA-1268020	9.799148e-01	0.009
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.805203e-01	0.009
Eukaryotic Translation Termination	R-HSA-72764	9.814316e-01	0.008
MHC class II antigen presentation	R-HSA-2132295	9.820294e-01	0.008
Ion transport by P-type ATPases	R-HSA-936837	9.820412e-01	0.008
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.823014e-01	0.008
Neutrophil degranulation	R-HSA-6798695	9.824011e-01	0.008
Hemostasis	R-HSA-109582	9.834198e-01	0.007
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.839376e-01	0.007
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.839427e-01	0.007
Kidney development	R-HSA-9830369	9.848166e-01	0.007
Nicotinate metabolism	R-HSA-196807	9.848166e-01	0.007
Interleukin-1 family signaling	R-HSA-446652	9.851838e-01	0.006
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.856430e-01	0.006
Selenocysteine synthesis	R-HSA-2408557	9.860901e-01	0.006
Interleukin-1 signaling	R-HSA-9020702	9.860901e-01	0.006
Neuronal System	R-HSA-112316	9.867167e-01	0.006
Extracellular matrix organization	R-HSA-1474244	9.870186e-01	0.006
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.873735e-01	0.006
Viral mRNA Translation	R-HSA-192823	9.873735e-01	0.006
Retinoid metabolism and transport	R-HSA-975634	9.878623e-01	0.005
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.878623e-01	0.005
Metabolism of cofactors	R-HSA-8978934	9.878623e-01	0.005
Metabolism of porphyrins	R-HSA-189445	9.878623e-01	0.005
Disease	R-HSA-1643685	9.883487e-01	0.005
Purine catabolism	R-HSA-74259	9.885231e-01	0.005
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.885231e-01	0.005
Aspirin ADME	R-HSA-9749641	9.891480e-01	0.005
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.900979e-01	0.004
Antigen processing-Cross presentation	R-HSA-1236975	9.905693e-01	0.004
Integration of energy metabolism	R-HSA-163685	9.911048e-01	0.004
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.913255e-01	0.004
ABC transporter disorders	R-HSA-5619084	9.917980e-01	0.004
SLC-mediated transport of organic anions	R-HSA-9955298	9.917980e-01	0.004
Cholesterol biosynthesis	R-HSA-191273	9.917980e-01	0.004
Signaling by Hedgehog	R-HSA-5358351	9.918641e-01	0.004
Pre-NOTCH Expression and Processing	R-HSA-1912422	9.926167e-01	0.003
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.930666e-01	0.003
Transport to the Golgi and subsequent modification	R-HSA-948021	9.941315e-01	0.003
Glycerophospholipid biosynthesis	R-HSA-1483206	9.943608e-01	0.002
Pyruvate metabolism	R-HSA-70268	9.953159e-01	0.002
ER-Phagosome pathway	R-HSA-1236974	9.958125e-01	0.002
Neurotransmitter release cycle	R-HSA-112310	9.960408e-01	0.002
Protein localization	R-HSA-9609507	9.960523e-01	0.002
Regulation of Complement cascade	R-HSA-977606	9.963041e-01	0.002
Ion channel transport	R-HSA-983712	9.969827e-01	0.001
Interferon gamma signaling	R-HSA-877300	9.970019e-01	0.001
Nucleotide catabolism	R-HSA-8956319	9.971197e-01	0.001
Translation	R-HSA-72766	9.972655e-01	0.001
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.973259e-01	0.001
Mitochondrial translation elongation	R-HSA-5389840	9.974717e-01	0.001
Mitochondrial translation initiation	R-HSA-5368286	9.977400e-01	0.001
Regulation of insulin secretion	R-HSA-422356	9.977400e-01	0.001
Synthesis of bile acids and bile salts	R-HSA-192105	9.978632e-01	0.001
Mitochondrial translation	R-HSA-5368287	9.983417e-01	0.001
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.984739e-01	0.001
Metabolism of proteins	R-HSA-392499	9.984992e-01	0.001
Keratinization	R-HSA-6805567	9.986250e-01	0.001
Immune System	R-HSA-168256	9.986402e-01	0.001
Metabolism of steroids	R-HSA-8957322	9.987532e-01	0.001
Infectious disease	R-HSA-5663205	9.987884e-01	0.001
Mitochondrial translation termination	R-HSA-5419276	9.988473e-01	0.001
Complement cascade	R-HSA-166658	9.988932e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.989102e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.989697e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.991094e-01	0.000
Innate Immune System	R-HSA-168249	9.991302e-01	0.000
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	9.992244e-01	0.000
Arachidonate metabolism	R-HSA-2142753	9.992244e-01	0.000
Neddylation	R-HSA-8951664	9.992950e-01	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	9.993346e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.994748e-01	0.000
Selenoamino acid metabolism	R-HSA-2408522	9.995799e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.996423e-01	0.000
Bacterial Infection Pathways	R-HSA-9824439	9.997203e-01	0.000
G alpha (s) signalling events	R-HSA-418555	9.997215e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.997324e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.997493e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.998195e-01	0.000
FCERI mediated NF-kB activation	R-HSA-2871837	9.998849e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999028e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999030e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999413e-01	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.999446e-01	0.000
Transport of small molecules	R-HSA-382551	9.999618e-01	0.000
Asparagine N-linked glycosylation	R-HSA-446203	9.999758e-01	0.000
Drug ADME	R-HSA-9748784	9.999771e-01	0.000
Signaling by GPCR	R-HSA-372790	9.999805e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999840e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999878e-01	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	9.999931e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999940e-01	0.000
Phase I - Functionalization of compounds	R-HSA-211945	9.999991e-01	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	9.999992e-01	0.000
Phase II - Conjugation of compounds	R-HSA-156580	9.999995e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999997e-01	0.000
GPCR ligand binding	R-HSA-500792	9.999997e-01	0.000
Fatty acid metabolism	R-HSA-8978868	9.999999e-01	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Biological oxidations	R-HSA-211859	1.000000e+00	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Cell Cycle	R-HSA-1640170	1.110223e-16	15.955
M Phase	R-HSA-68886	1.554312e-15	14.808
Mitotic Anaphase	R-HSA-68882	2.886580e-15	14.540
Mitotic Metaphase and Anaphase	R-HSA-2555396	3.552714e-15	14.449
Separation of Sister Chromatids	R-HSA-2467813	5.773160e-15	14.239
Cell Cycle, Mitotic	R-HSA-69278	5.440093e-15	14.264
Mitotic Prometaphase	R-HSA-68877	4.674039e-14	13.330
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.212364e-13	12.916
Cellular responses to stimuli	R-HSA-8953897	3.265166e-13	12.486
Cellular responses to stress	R-HSA-2262752	4.786171e-13	12.320
Apoptotic execution phase	R-HSA-75153	7.069900e-13	12.151
Metabolism of RNA	R-HSA-8953854	8.045231e-12	11.094
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	4.017497e-11	10.396
Cell-Cell communication	R-HSA-1500931	6.692613e-11	10.174
Axon guidance	R-HSA-422475	7.982170e-11	10.098
Cell Cycle Checkpoints	R-HSA-69620	1.042825e-10	9.982
Cellular response to heat stress	R-HSA-3371556	1.895373e-10	9.722
Apoptotic cleavage of cellular proteins	R-HSA-111465	3.672030e-10	9.435
Nervous system development	R-HSA-9675108	4.009395e-10	9.397
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	8.401383e-10	9.076
Cell junction organization	R-HSA-446728	1.784772e-09	8.748
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.861372e-09	8.730
Recycling pathway of L1	R-HSA-437239	3.113299e-09	8.507
G2/M Transition	R-HSA-69275	3.164434e-09	8.500
Aggrephagy	R-HSA-9646399	3.419626e-09	8.466
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	4.081284e-09	8.389
Mitotic G2-G2/M phases	R-HSA-453274	4.367102e-09	8.360
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	4.946783e-09	8.306
Apoptosis	R-HSA-109581	6.107480e-09	8.214
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	6.589711e-09	8.181
Regulation of CDH1 Expression and Function	R-HSA-9764265	6.589711e-09	8.181
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	7.026829e-09	8.153
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	8.250257e-09	8.084
L1CAM interactions	R-HSA-373760	1.781394e-08	7.749
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	2.767312e-08	7.558
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	3.679289e-08	7.434
Transport of connexons to the plasma membrane	R-HSA-190872	4.888431e-08	7.311
Adherens junctions interactions	R-HSA-418990	6.946939e-08	7.158
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	1.309888e-07	6.883
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.428224e-07	6.845
Programmed Cell Death	R-HSA-5357801	1.491212e-07	6.826
Cell-cell junction organization	R-HSA-421270	1.832374e-07	6.737
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	1.769531e-07	6.752
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	2.301266e-07	6.638
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	2.940917e-07	6.532
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	2.896850e-07	6.538
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	3.866349e-07	6.413
Selective autophagy	R-HSA-9663891	4.049584e-07	6.393
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	4.221086e-07	6.375
Signaling by ALK in cancer	R-HSA-9700206	4.221086e-07	6.375
Membrane Trafficking	R-HSA-199991	5.435923e-07	6.265
Ribosomal scanning and start codon recognition	R-HSA-72702	7.650636e-07	6.116
Signaling by Hippo	R-HSA-2028269	1.106166e-06	5.956
G2/M Checkpoints	R-HSA-69481	1.150981e-06	5.939
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	1.273159e-06	5.895
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	1.245872e-06	5.905
Gap junction trafficking and regulation	R-HSA-157858	1.549391e-06	5.810
Translation initiation complex formation	R-HSA-72649	1.610893e-06	5.793
Cohesin Loading onto Chromatin	R-HSA-2470946	1.790258e-06	5.747
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	2.031500e-06	5.692
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	2.031500e-06	5.692
Mitotic Spindle Checkpoint	R-HSA-69618	2.107452e-06	5.676
HSF1-dependent transactivation	R-HSA-3371571	2.623192e-06	5.581
Post NMDA receptor activation events	R-HSA-438064	2.901551e-06	5.537
Signal Transduction	R-HSA-162582	3.275354e-06	5.485
Regulation of CDH1 Function	R-HSA-9764561	3.385118e-06	5.470
Post-chaperonin tubulin folding pathway	R-HSA-389977	4.361981e-06	5.360
PKR-mediated signaling	R-HSA-9833482	5.158791e-06	5.287
Gap junction trafficking	R-HSA-190828	5.351206e-06	5.272
Chromatin organization	R-HSA-4839726	5.842948e-06	5.233
Activation of AMPK downstream of NMDARs	R-HSA-9619483	5.883093e-06	5.230
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	7.148274e-06	5.146
Interleukin-12 signaling	R-HSA-9020591	6.868349e-06	5.163
Cap-dependent Translation Initiation	R-HSA-72737	7.186141e-06	5.144
Eukaryotic Translation Initiation	R-HSA-72613	7.186141e-06	5.144
HIV Life Cycle	R-HSA-162587	9.427959e-06	5.026
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	9.612174e-06	5.017
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.101088e-05	4.958
Downregulation of ERBB2 signaling	R-HSA-8863795	1.141653e-05	4.942
Macroautophagy	R-HSA-1632852	1.201274e-05	4.920
Estrogen-dependent gene expression	R-HSA-9018519	1.417683e-05	4.848
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.432260e-05	4.844
Influenza Infection	R-HSA-168255	1.489802e-05	4.827
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	1.579033e-05	4.802
Amplification of signal from the kinetochores	R-HSA-141424	1.579033e-05	4.802
SARS-CoV-1-host interactions	R-HSA-9692914	1.777747e-05	4.750
Autophagy	R-HSA-9612973	1.852476e-05	4.732
COPI-mediated anterograde transport	R-HSA-6807878	2.022948e-05	4.694
Kinesins	R-HSA-983189	2.127848e-05	4.672
Interleukin-12 family signaling	R-HSA-447115	2.238144e-05	4.650
Downregulation of ERBB4 signaling	R-HSA-1253288	3.016776e-05	4.520
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	3.129914e-05	4.504
Oncogenic MAPK signaling	R-HSA-6802957	3.583472e-05	4.446
Late Phase of HIV Life Cycle	R-HSA-162599	3.521286e-05	4.453
Cellular Senescence	R-HSA-2559583	3.518859e-05	4.454
DNA Damage Recognition in GG-NER	R-HSA-5696394	3.761092e-05	4.425
mRNA Splicing - Major Pathway	R-HSA-72163	3.793854e-05	4.421
G2/M DNA damage checkpoint	R-HSA-69473	3.847893e-05	4.415
HIV Infection	R-HSA-162906	3.852287e-05	4.414
Chromatin modifying enzymes	R-HSA-3247509	3.905426e-05	4.408
Clathrin-mediated endocytosis	R-HSA-8856828	3.987181e-05	4.399
Mitotic Telophase/Cytokinesis	R-HSA-68884	4.305167e-05	4.366
Listeria monocytogenes entry into host cells	R-HSA-8876384	4.546592e-05	4.342
ISG15 antiviral mechanism	R-HSA-1169408	4.606929e-05	4.337
Cell-extracellular matrix interactions	R-HSA-446353	4.890409e-05	4.311
Chaperone Mediated Autophagy	R-HSA-9613829	4.900144e-05	4.310
Gap junction assembly	R-HSA-190861	4.944064e-05	4.306
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	5.132941e-05	4.290
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	5.860632e-05	4.232
mRNA Splicing	R-HSA-72172	5.887474e-05	4.230
Signaling by ERBB2	R-HSA-1227986	6.375985e-05	4.195
Attenuation phase	R-HSA-3371568	6.493875e-05	4.187
MITF-M-regulated melanocyte development	R-HSA-9730414	7.294766e-05	4.137
Developmental Lineages of the Mammary Gland	R-HSA-9924644	7.418289e-05	4.130
HSF1 activation	R-HSA-3371511	8.322403e-05	4.080
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	8.835380e-05	4.054
rRNA processing in the nucleus and cytosol	R-HSA-8868773	8.256511e-05	4.083
MITF-M-dependent gene expression	R-HSA-9856651	9.164734e-05	4.038
Signaling by ROBO receptors	R-HSA-376176	9.495598e-05	4.022
Signaling downstream of RAS mutants	R-HSA-9649948	9.920051e-05	4.003
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	9.920051e-05	4.003
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	9.920051e-05	4.003
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	9.920051e-05	4.003
Signaling by RAS mutants	R-HSA-6802949	9.920051e-05	4.003
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	1.101625e-04	3.958
Signaling by RAF1 mutants	R-HSA-9656223	1.041676e-04	3.982
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	1.036745e-04	3.984
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	1.101625e-04	3.958
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.126482e-04	3.948
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.126482e-04	3.948
Host Interactions of HIV factors	R-HSA-162909	1.216802e-04	3.915
FLT3 signaling by CBL mutants	R-HSA-9706377	1.232304e-04	3.909
Centrosome maturation	R-HSA-380287	1.241017e-04	3.906
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.323048e-04	3.878
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	1.419902e-04	3.848
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	1.487102e-04	3.828
Chaperonin-mediated protein folding	R-HSA-390466	1.491864e-04	3.826
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.419214e-04	3.848
Eukaryotic Translation Elongation	R-HSA-156842	1.480837e-04	3.829
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	1.573928e-04	3.803
Influenza Viral RNA Transcription and Replication	R-HSA-168273	1.598619e-04	3.796
SWI/SNF chromatin remodelers	R-HSA-9932451	1.628597e-04	3.788
ATP-dependent chromatin remodelers	R-HSA-9932444	1.628597e-04	3.788
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	1.630217e-04	3.788
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	1.754543e-04	3.756
AURKA Activation by TPX2	R-HSA-8854518	1.921013e-04	3.716
Cilium Assembly	R-HSA-5617833	1.982849e-04	3.703
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	2.111854e-04	3.675
Interactions of Rev with host cellular proteins	R-HSA-177243	2.146721e-04	3.668
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	2.111854e-04	3.675
Hedgehog 'off' state	R-HSA-5610787	2.207380e-04	3.656
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	2.335554e-04	3.632
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	2.487682e-04	3.604
NF-kB is activated and signals survival	R-HSA-209560	2.492623e-04	3.603
Transcriptional Regulation by MECP2	R-HSA-8986944	2.678619e-04	3.572
Gene Silencing by RNA	R-HSA-211000	2.761831e-04	3.559
Transcriptional Regulation by TP53	R-HSA-3700989	2.935009e-04	3.532
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	2.990049e-04	3.524
Semaphorin interactions	R-HSA-373755	3.088991e-04	3.510
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	3.159060e-04	3.500
S Phase	R-HSA-69242	3.160514e-04	3.500
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	3.534199e-04	3.452
Protein folding	R-HSA-391251	3.537880e-04	3.451
Regulation of MECP2 expression and activity	R-HSA-9022692	3.683358e-04	3.434
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	3.546001e-04	3.450
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	3.534199e-04	3.452
MAPK family signaling cascades	R-HSA-5683057	3.390336e-04	3.470
Smooth Muscle Contraction	R-HSA-445355	3.990087e-04	3.399
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	4.066212e-04	3.391
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	4.326161e-04	3.364
Cargo trafficking to the periciliary membrane	R-HSA-5620920	4.355299e-04	3.361
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	4.397851e-04	3.357
Unfolded Protein Response (UPR)	R-HSA-381119	4.542861e-04	3.343
Regulation of CDH11 Expression and Function	R-HSA-9759475	4.775114e-04	3.321
Nucleotide Excision Repair	R-HSA-5696398	4.796355e-04	3.319
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	4.964128e-04	3.304
Transcriptional regulation by small RNAs	R-HSA-5578749	5.079796e-04	3.294
SARS-CoV-2-host interactions	R-HSA-9705683	5.172420e-04	3.286
Apoptosis induced DNA fragmentation	R-HSA-140342	5.671502e-04	3.246
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	5.687889e-04	3.245
Nuclear import of Rev protein	R-HSA-180746	5.829619e-04	3.234
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	5.906576e-04	3.229
ESR-mediated signaling	R-HSA-8939211	5.969985e-04	3.224
Signaling by EGFR	R-HSA-177929	6.747599e-04	3.171
Long-term potentiation	R-HSA-9620244	6.126412e-04	3.213
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	6.040103e-04	3.219
SARS-CoV-1 Infection	R-HSA-9678108	6.534021e-04	3.185
RNA Polymerase II Pre-transcription Events	R-HSA-674695	6.847314e-04	3.164
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	6.890719e-04	3.162
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	7.452384e-04	3.128
Processing of DNA double-strand break ends	R-HSA-5693607	7.712245e-04	3.113
Nuclear Envelope Breakdown	R-HSA-2980766	7.972018e-04	3.098
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	8.134976e-04	3.090
PKMTs methylate histone lysines	R-HSA-3214841	8.142450e-04	3.089
Ribosome-associated quality control	R-HSA-9948299	8.240724e-04	3.084
Signaling by Hedgehog	R-HSA-5358351	8.240724e-04	3.084
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	8.244278e-04	3.084
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	9.632657e-04	3.016
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	9.632657e-04	3.016
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	9.632657e-04	3.016
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	9.632657e-04	3.016
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	9.632657e-04	3.016
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	9.632657e-04	3.016
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	9.632657e-04	3.016
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	9.632657e-04	3.016
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	9.632657e-04	3.016
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	9.632657e-04	3.016
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	9.632657e-04	3.016
Post-transcriptional silencing by small RNAs	R-HSA-426496	1.016899e-03	2.993
mTORC1-mediated signalling	R-HSA-166208	1.014673e-03	2.994
Regulation of PD-L1(CD274) expression	R-HSA-9909648	9.376160e-04	3.028
MAP2K and MAPK activation	R-HSA-5674135	9.875387e-04	3.005
Vesicle-mediated transport	R-HSA-5653656	9.792922e-04	3.009
Regulation of mitotic cell cycle	R-HSA-453276	1.077449e-03	2.968
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	1.077449e-03	2.968
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	1.085911e-03	2.964
Vpr-mediated nuclear import of PICs	R-HSA-180910	1.096858e-03	2.960
Metabolism of non-coding RNA	R-HSA-194441	1.099734e-03	2.959
snRNP Assembly	R-HSA-191859	1.099734e-03	2.959
p75NTR signals via NF-kB	R-HSA-193639	1.143954e-03	2.942
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	1.143954e-03	2.942
Activation of BAD and translocation to mitochondria	R-HSA-111447	1.143954e-03	2.942
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	1.154110e-03	2.938
Transport of the SLBP independent Mature mRNA	R-HSA-159227	1.197318e-03	2.922
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	1.197318e-03	2.922
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.248288e-03	2.904
Intraflagellar transport	R-HSA-5620924	1.249840e-03	2.903
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	1.288829e-03	2.890
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	1.288829e-03	2.890
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	1.288829e-03	2.890
MAPK6/MAPK4 signaling	R-HSA-5687128	1.313568e-03	2.882
Transcriptional regulation by RUNX1	R-HSA-8878171	1.373917e-03	2.862
Switching of origins to a post-replicative state	R-HSA-69052	1.426583e-03	2.846
Striated Muscle Contraction	R-HSA-390522	1.475925e-03	2.831
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	1.475925e-03	2.831
Degradation of CDH1	R-HSA-9766229	1.480771e-03	2.830
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	1.500742e-03	2.824
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	1.616210e-03	2.792
Negative regulation of MET activity	R-HSA-6807004	1.685596e-03	2.773
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	1.753667e-03	2.756
Protein ubiquitination	R-HSA-8852135	1.867463e-03	2.729
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	1.733118e-03	2.761
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	1.818441e-03	2.740
Gene expression (Transcription)	R-HSA-74160	1.887262e-03	2.724
Regulation of TP53 Activity	R-HSA-5633007	1.923515e-03	2.716
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.943841e-03	2.711
Interactions of Vpr with host cellular proteins	R-HSA-176033	1.943841e-03	2.711
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.982643e-03	2.703
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	2.005006e-03	2.698
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	2.021666e-03	2.694
Nucleosome assembly	R-HSA-774815	2.021666e-03	2.694
Interferon Signaling	R-HSA-913531	2.070132e-03	2.684
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	2.121916e-03	2.673
ER to Golgi Anterograde Transport	R-HSA-199977	2.126950e-03	2.672
rRNA processing	R-HSA-72312	2.127553e-03	2.672
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	2.187531e-03	2.660
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	2.187531e-03	2.660
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	2.194180e-03	2.659
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	2.216997e-03	2.654
Nonsense-Mediated Decay (NMD)	R-HSA-927802	2.239663e-03	2.650
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	2.239663e-03	2.650
Glycolysis	R-HSA-70171	2.355009e-03	2.628
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	2.387535e-03	2.622
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	2.387535e-03	2.622
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	2.397750e-03	2.620
EGFR downregulation	R-HSA-182971	2.440069e-03	2.613
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	2.440069e-03	2.613
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	2.440069e-03	2.613
Homology Directed Repair	R-HSA-5693538	2.521272e-03	2.598
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	2.584952e-03	2.588
Regulation of TP53 Degradation	R-HSA-6804757	2.648070e-03	2.577
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	2.648070e-03	2.577
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	2.656420e-03	2.576
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	3.006303e-03	2.522
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	2.967077e-03	2.528
Folding of actin by CCT/TriC	R-HSA-390450	2.967077e-03	2.528
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	2.806324e-03	2.552
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	2.792114e-03	2.554
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	3.150134e-03	2.502
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	3.031458e-03	2.518
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	3.048655e-03	2.516
Formation of a pool of free 40S subunits	R-HSA-72689	2.832688e-03	2.548
Co-inhibition by PD-1	R-HSA-389948	2.832032e-03	2.548
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	2.735655e-03	2.563
Josephin domain DUBs	R-HSA-5689877	2.967077e-03	2.528
Golgi-to-ER retrograde transport	R-HSA-8856688	3.076588e-03	2.512
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	3.238486e-03	2.490
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	2.967077e-03	2.528
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	3.238486e-03	2.490
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	3.274527e-03	2.485
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	3.292850e-03	2.482
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	3.408968e-03	2.467
NRIF signals cell death from the nucleus	R-HSA-205043	3.525387e-03	2.453
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	3.525387e-03	2.453
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	3.544751e-03	2.450
DNA Double-Strand Break Repair	R-HSA-5693532	3.558314e-03	2.449
IPs transport between nucleus and cytosol	R-HSA-1855170	3.610433e-03	2.442
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	3.610433e-03	2.442
Signaling by NOTCH3	R-HSA-9012852	3.741858e-03	2.427
EPH-Ephrin signaling	R-HSA-2682334	3.804208e-03	2.420
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	3.847084e-03	2.415
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	3.935296e-03	2.405
Developmental Biology	R-HSA-1266738	4.006761e-03	2.397
tRNA processing in the nucleus	R-HSA-6784531	4.135099e-03	2.384
MAPK1/MAPK3 signaling	R-HSA-5684996	4.295356e-03	2.367
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	4.307474e-03	2.366
p75 NTR receptor-mediated signalling	R-HSA-193704	4.333985e-03	2.363
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	4.344195e-03	2.362
RAF/MAP kinase cascade	R-HSA-5673001	4.480360e-03	2.349
Regulation of TP53 Expression and Degradation	R-HSA-6806003	4.484626e-03	2.348
NS1 Mediated Effects on Host Pathways	R-HSA-168276	4.484626e-03	2.348
Peptide chain elongation	R-HSA-156902	4.583690e-03	2.339
Regulation of PTEN localization	R-HSA-8948747	4.671993e-03	2.330
DNA Repair	R-HSA-73894	4.686965e-03	2.329
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	4.705876e-03	2.327
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	4.705876e-03	2.327
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	4.714769e-03	2.327
Signaling by PTK6	R-HSA-8848021	4.714769e-03	2.327
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	4.826816e-03	2.316
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	5.050078e-03	2.297
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	5.225444e-03	2.282
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	5.250427e-03	2.280
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	5.360121e-03	2.271
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	5.488501e-03	2.261
Dual incision in TC-NER	R-HSA-6782135	5.647636e-03	2.248
Viral Infection Pathways	R-HSA-9824446	5.694949e-03	2.245
Regulation of endogenous retroelements	R-HSA-9842860	5.851529e-03	2.233
Deubiquitination	R-HSA-5688426	5.854380e-03	2.233
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	5.899352e-03	2.229
Formation of RNA Pol II elongation complex	R-HSA-112382	5.899352e-03	2.229
Nephrin family interactions	R-HSA-373753	5.949177e-03	2.226
Signaling by ERBB2 in Cancer	R-HSA-1227990	5.952101e-03	2.225
Formation of annular gap junctions	R-HSA-196025	6.906540e-03	2.161
Regulation of NPAS4 mRNA translation	R-HSA-9768778	6.906540e-03	2.161
Negative regulation of FLT3	R-HSA-9706369	6.161963e-03	2.210
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	6.161963e-03	2.210
Sema4D in semaphorin signaling	R-HSA-400685	6.726756e-03	2.172
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	7.036664e-03	2.153
RNA Polymerase II Transcription Elongation	R-HSA-75955	6.762938e-03	2.170
Golgi Associated Vesicle Biogenesis	R-HSA-432722	6.762938e-03	2.170
PTEN Regulation	R-HSA-6807070	6.121101e-03	2.213
TGFBR3 expression	R-HSA-9839394	6.726756e-03	2.172
trans-Golgi Network Vesicle Budding	R-HSA-199992	6.410255e-03	2.193
Regulation of T cell activation by CD28 family	R-HSA-388841	6.217551e-03	2.206
Death Receptor Signaling	R-HSA-73887	6.852369e-03	2.164
DNA Replication Pre-Initiation	R-HSA-69002	6.456588e-03	2.190
Oncogene Induced Senescence	R-HSA-2559585	6.164989e-03	2.210
Transcriptional Regulation by VENTX	R-HSA-8853884	6.193721e-03	2.208
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	6.906540e-03	2.161
XBP1(S) activates chaperone genes	R-HSA-381038	7.613448e-03	2.118
IRE1alpha activates chaperones	R-HSA-381070	6.984186e-03	2.156
DNA Double Strand Break Response	R-HSA-5693606	7.731231e-03	2.112
p75NTR recruits signalling complexes	R-HSA-209543	7.922459e-03	2.101
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	7.929893e-03	2.101
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	8.094262e-03	2.092
Signaling by EGFR in Cancer	R-HSA-1643713	8.168614e-03	2.088
Assembly of the pre-replicative complex	R-HSA-68867	8.521760e-03	2.069
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	8.992355e-03	2.046
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	9.188247e-03	2.037
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	9.331382e-03	2.030
Gap junction degradation	R-HSA-190873	9.797457e-03	2.009
ALK mutants bind TKIs	R-HSA-9700645	9.797457e-03	2.009
Cellular response to mitochondrial stress	R-HSA-9840373	9.797457e-03	2.009
Interaction between L1 and Ankyrins	R-HSA-445095	9.834070e-03	2.007
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	9.971262e-03	2.001
UCH proteinases	R-HSA-5689603	1.001736e-02	1.999
Activation of ATR in response to replication stress	R-HSA-176187	1.004570e-02	1.998
HCMV Early Events	R-HSA-9609690	1.013027e-02	1.994
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	1.020326e-02	1.991
Synthesis of DNA	R-HSA-69239	1.020326e-02	1.991
Organelle biogenesis and maintenance	R-HSA-1852241	1.031568e-02	1.987
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	1.044349e-02	1.981
SARS-CoV Infections	R-HSA-9679506	1.047134e-02	1.980
Signaling by TGFB family members	R-HSA-9006936	1.063297e-02	1.973
Mitotic Prophase	R-HSA-68875	1.077352e-02	1.968
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	1.106552e-02	1.956
Maturation of protein E	R-HSA-9694493	1.106552e-02	1.956
Maturation of protein E	R-HSA-9683683	1.106552e-02	1.956
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	1.123012e-02	1.950
Oxidative Stress Induced Senescence	R-HSA-2559580	1.125663e-02	1.949
Chromosome Maintenance	R-HSA-73886	1.168523e-02	1.932
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.212686e-02	1.916
Ephrin signaling	R-HSA-3928664	1.254632e-02	1.901
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.270113e-02	1.896
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	1.274068e-02	1.895
SARS-CoV-2 Infection	R-HSA-9694516	1.314745e-02	1.881
TCR signaling	R-HSA-202403	1.319783e-02	1.879
Formation of Incision Complex in GG-NER	R-HSA-5696395	1.334944e-02	1.875
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	1.342613e-02	1.872
Pexophagy	R-HSA-9664873	1.342613e-02	1.872
Orc1 removal from chromatin	R-HSA-68949	1.362799e-02	1.866
Sensory processing of sound	R-HSA-9659379	1.365822e-02	1.865
MHC class II antigen presentation	R-HSA-2132295	1.369467e-02	1.863
Dual Incision in GG-NER	R-HSA-5696400	1.377972e-02	1.861
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	1.377972e-02	1.861
Calnexin/calreticulin cycle	R-HSA-901042	1.377972e-02	1.861
Intracellular signaling by second messengers	R-HSA-9006925	1.380475e-02	1.860
Signaling by ERBB2 KD Mutants	R-HSA-9664565	1.391637e-02	1.856
Late endosomal microautophagy	R-HSA-9615710	1.391637e-02	1.856
PIP3 activates AKT signaling	R-HSA-1257604	1.451272e-02	1.838
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	1.452475e-02	1.838
Regulation of TNFR1 signaling	R-HSA-5357905	1.452475e-02	1.838
Signaling by TGFBR3	R-HSA-9839373	1.452475e-02	1.838
Glucose metabolism	R-HSA-70326	1.519018e-02	1.818
Hh mutants are degraded by ERAD	R-HSA-5362768	1.534016e-02	1.814
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	1.534016e-02	1.814
Meiotic synapsis	R-HSA-1221632	1.538302e-02	1.813
Translesion Synthesis by POLH	R-HSA-110320	1.546568e-02	1.811
Cellular response to starvation	R-HSA-9711097	1.553549e-02	1.809
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.599608e-02	1.796
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	1.628925e-02	1.788
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	1.632946e-02	1.787
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	1.709978e-02	1.767
ERBB2 Regulates Cell Motility	R-HSA-6785631	1.709978e-02	1.767
Spry regulation of FGF signaling	R-HSA-1295596	1.709978e-02	1.767
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	1.709978e-02	1.767
Epigenetic regulation of gene expression	R-HSA-212165	1.755044e-02	1.756
ABC-family proteins mediated transport	R-HSA-382556	1.760504e-02	1.754
Muscle contraction	R-HSA-397014	1.774385e-02	1.751
Viral Messenger RNA Synthesis	R-HSA-168325	1.784031e-02	1.749
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	1.786571e-02	1.748
Regulation of localization of FOXO transcription factors	R-HSA-9614399	1.786571e-02	1.748
FLT3 signaling in disease	R-HSA-9682385	1.846639e-02	1.734
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	1.957076e-02	1.708
Phosphorylation of the APC/C	R-HSA-176412	2.132832e-02	1.671
Regulation of PD-L1(CD274) translation	R-HSA-9909620	1.883751e-02	1.725
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.883751e-02	1.725
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	1.913333e-02	1.718
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	2.193799e-02	1.659
MicroRNA (miRNA) biogenesis	R-HSA-203927	1.935709e-02	1.713
PCP/CE pathway	R-HSA-4086400	2.428104e-02	1.615
Myogenesis	R-HSA-525793	2.281585e-02	1.642
Degradation of DVL	R-HSA-4641258	2.120604e-02	1.674
Diseases of mitotic cell cycle	R-HSA-9675126	2.221553e-02	1.653
Hh mutants abrogate ligand secretion	R-HSA-5387390	2.265333e-02	1.645
NRAGE signals death through JNK	R-HSA-193648	2.168799e-02	1.664
VEGFA-VEGFR2 Pathway	R-HSA-4420097	2.291438e-02	1.640
Eukaryotic Translation Termination	R-HSA-72764	2.123005e-02	1.673
Signaling by TGF-beta Receptor Complex	R-HSA-170834	2.501275e-02	1.602
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	2.102175e-02	1.677
Regulation of BACH1 activity	R-HSA-9708530	2.132832e-02	1.671
Beta-catenin independent WNT signaling	R-HSA-3858494	2.534597e-02	1.596
RMTs methylate histone arginines	R-HSA-3214858	2.557990e-02	1.592
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	2.563787e-02	1.591
Ub-specific processing proteases	R-HSA-5689880	2.619117e-02	1.582
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	2.621212e-02	1.581
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	2.621212e-02	1.581
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	2.621212e-02	1.581
Hedgehog ligand biogenesis	R-HSA-5358346	2.641372e-02	1.578
KEAP1-NFE2L2 pathway	R-HSA-9755511	2.652572e-02	1.576
EPHA-mediated growth cone collapse	R-HSA-3928663	2.668791e-02	1.574
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	2.668791e-02	1.574
Regulation of gap junction activity	R-HSA-191650	2.687670e-02	1.571
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	2.687670e-02	1.571
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	2.687670e-02	1.571
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	2.706175e-02	1.568
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	2.706175e-02	1.568
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	2.706175e-02	1.568
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	2.755253e-02	1.560
Stabilization of p53	R-HSA-69541	2.755253e-02	1.560
Transcriptional Regulation by E2F6	R-HSA-8953750	2.755253e-02	1.560
Cytokine Signaling in Immune system	R-HSA-1280215	2.781904e-02	1.556
Asymmetric localization of PCP proteins	R-HSA-4608870	2.877090e-02	1.541
Defective CFTR causes cystic fibrosis	R-HSA-5678895	2.877090e-02	1.541
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	2.941965e-02	1.531
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	2.941965e-02	1.531
VLDLR internalisation and degradation	R-HSA-8866427	2.941965e-02	1.531
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	2.945866e-02	1.531
mRNA 3'-end processing	R-HSA-72187	2.945866e-02	1.531
Transcriptional Regulation by NPAS4	R-HSA-9634815	2.945866e-02	1.531
Myoclonic epilepsy of Lafora	R-HSA-3785653	3.096034e-02	1.509
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	3.096034e-02	1.509
Modulation by Mtb of host immune system	R-HSA-9637628	3.096034e-02	1.509
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	3.099402e-02	1.509
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	3.118735e-02	1.506
Regulation of RUNX3 expression and activity	R-HSA-8941858	3.118735e-02	1.506
Negative regulation of NOTCH4 signaling	R-HSA-9604323	3.118735e-02	1.506
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	3.178598e-02	1.498
Regulation of NPAS4 gene expression	R-HSA-9768759	3.178598e-02	1.498
Signaling by NOTCH4	R-HSA-9013694	3.224335e-02	1.492
HDR through Homologous Recombination (HRR)	R-HSA-5685942	3.266302e-02	1.486
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	3.274910e-02	1.485
Regulation of PTEN gene transcription	R-HSA-8943724	3.285711e-02	1.483
Mitophagy	R-HSA-5205647	3.357010e-02	1.474
Selenocysteine synthesis	R-HSA-2408557	3.408465e-02	1.467
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	3.514725e-02	1.454
Transcription of the HIV genome	R-HSA-167172	3.581127e-02	1.446
ER-Phagosome pathway	R-HSA-1236974	3.636160e-02	1.439
Regulation of PTEN mRNA translation	R-HSA-8943723	3.743833e-02	1.427
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	3.801723e-02	1.420
Signaling by ERBB2 ECD mutants	R-HSA-9665348	3.807894e-02	1.419
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	3.807894e-02	1.419
Depolymerization of the Nuclear Lamina	R-HSA-4419969	3.807894e-02	1.419
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	3.807894e-02	1.419
Regulation of TP53 Activity through Methylation	R-HSA-6804760	3.807894e-02	1.419
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	3.811052e-02	1.419
Regulation of Apoptosis	R-HSA-169911	3.811052e-02	1.419
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	3.811052e-02	1.419
Viral mRNA Translation	R-HSA-192823	3.944123e-02	1.404
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	3.944410e-02	1.404
Degradation of GLI1 by the proteasome	R-HSA-5610780	3.944410e-02	1.404
HIV Transcription Initiation	R-HSA-167161	3.944410e-02	1.404
RNA Polymerase II Transcription Initiation	R-HSA-75953	3.944410e-02	1.404
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	3.953255e-02	1.403
NrCAM interactions	R-HSA-447038	3.953255e-02	1.403
GP1b-IX-V activation signalling	R-HSA-430116	4.043977e-02	1.393
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	4.043977e-02	1.393
RNA Polymerase II Transcription	R-HSA-73857	4.065886e-02	1.391
SHC1 events in ERBB2 signaling	R-HSA-1250196	4.098172e-02	1.387
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	4.098172e-02	1.387
Activation of BH3-only proteins	R-HSA-114452	4.098172e-02	1.387
Manipulation of host energy metabolism	R-HSA-9636667	4.109460e-02	1.386
rRNA modification in the nucleus and cytosol	R-HSA-6790901	4.359824e-02	1.361
Meiosis	R-HSA-1500620	4.389141e-02	1.358
MTOR signalling	R-HSA-165159	4.408874e-02	1.356
TNF signaling	R-HSA-75893	4.418192e-02	1.355
DNA Damage Bypass	R-HSA-73893	4.439514e-02	1.353
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	4.439514e-02	1.353
p53-Dependent G1 DNA Damage Response	R-HSA-69563	4.439514e-02	1.353
Regulation of KIT signaling	R-HSA-1433559	4.482895e-02	1.348
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	4.482895e-02	1.348
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	4.482895e-02	1.348
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	4.482895e-02	1.348
Regulation of signaling by CBL	R-HSA-912631	4.511394e-02	1.346
IKK complex recruitment mediated by RIP1	R-HSA-937041	4.511394e-02	1.346
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	4.527778e-02	1.344
Budding and maturation of HIV virion	R-HSA-162588	4.669459e-02	1.331
DNA Replication	R-HSA-69306	4.730086e-02	1.325
Signaling by VEGF	R-HSA-194138	4.823410e-02	1.317
Signaling by NOTCH	R-HSA-157118	4.857470e-02	1.314
RNA Polymerase II Promoter Escape	R-HSA-73776	4.909088e-02	1.309
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	6.822409e-02	1.166
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	5.468562e-02	1.262
IkBA variant leads to EDA-ID	R-HSA-5603029	5.468562e-02	1.262
PECAM1 interactions	R-HSA-210990	6.379264e-02	1.195
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	5.404262e-02	1.267
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	5.404262e-02	1.267
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	5.404262e-02	1.267
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	5.404262e-02	1.267
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	5.404262e-02	1.267
Class I peroxisomal membrane protein import	R-HSA-9603798	6.427208e-02	1.192
Translesion synthesis by POLI	R-HSA-5656121	6.427208e-02	1.192
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	6.427208e-02	1.192
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	6.526516e-02	1.185
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	6.684645e-02	1.175
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	5.445903e-02	1.264
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	6.020043e-02	1.220
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	7.282516e-02	1.138
Neutrophil degranulation	R-HSA-6798695	5.032355e-02	1.298
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	6.146985e-02	1.211
EPHB-mediated forward signaling	R-HSA-3928662	5.445903e-02	1.264
Regulation of necroptotic cell death	R-HSA-5675482	5.961869e-02	1.225
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	5.739218e-02	1.241
HATs acetylate histones	R-HSA-3214847	5.070939e-02	1.295
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	5.058976e-02	1.296
DCC mediated attractive signaling	R-HSA-418885	5.404262e-02	1.267
Sema3A PAK dependent Axon repulsion	R-HSA-399954	5.404262e-02	1.267
Metalloprotease DUBs	R-HSA-5689901	5.739218e-02	1.241
Regulation of CDH11 function	R-HSA-9762292	5.138827e-02	1.289
Translesion synthesis by REV1	R-HSA-110312	5.404262e-02	1.267
TCF dependent signaling in response to WNT	R-HSA-201681	6.744590e-02	1.171
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	5.182820e-02	1.285
Translation	R-HSA-72766	6.101875e-02	1.215
HCMV Infection	R-HSA-9609646	5.256866e-02	1.279
HDMs demethylate histones	R-HSA-3214842	5.013602e-02	1.300
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	6.655509e-02	1.177
Platelet degranulation	R-HSA-114608	5.443277e-02	1.264
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	5.322523e-02	1.274
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	6.822409e-02	1.166
Negative regulation of FGFR3 signaling	R-HSA-5654732	7.375896e-02	1.132
RNA Polymerase II Transcription Termination	R-HSA-73856	6.888135e-02	1.162
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	5.739218e-02	1.241
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	6.020043e-02	1.220
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	6.020043e-02	1.220
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	6.164636e-02	1.210
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	7.080461e-02	1.150
Nef and signal transduction	R-HSA-164944	7.219056e-02	1.142
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	6.379264e-02	1.195
Vpu mediated degradation of CD4	R-HSA-180534	6.684645e-02	1.175
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	7.080461e-02	1.150
ER Quality Control Compartment (ERQC)	R-HSA-901032	6.526516e-02	1.185
Regulation of CDH19 Expression and Function	R-HSA-9764302	5.468562e-02	1.262
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	7.411818e-02	1.130
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	7.411818e-02	1.130
VEGFR2 mediated vascular permeability	R-HSA-5218920	7.411818e-02	1.130
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	7.411818e-02	1.130
RAF activation	R-HSA-5673000	7.459128e-02	1.127
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	7.459128e-02	1.127
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	7.459128e-02	1.127
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	7.459128e-02	1.127
GRB2 events in ERBB2 signaling	R-HSA-1963640	7.551036e-02	1.122
Translesion synthesis by POLK	R-HSA-5655862	7.551036e-02	1.122
Transport to the Golgi and subsequent modification	R-HSA-948021	7.598194e-02	1.119
PI3K/AKT Signaling in Cancer	R-HSA-2219528	7.603494e-02	1.119
Integration of provirus	R-HSA-162592	7.761662e-02	1.110
Cyclin E associated events during G1/S transition	R-HSA-69202	7.762434e-02	1.110
Gluconeogenesis	R-HSA-70263	7.971611e-02	1.098
G1/S DNA Damage Checkpoints	R-HSA-69615	8.086169e-02	1.092
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	8.090923e-02	1.092
Degradation of GLI2 by the proteasome	R-HSA-5610783	8.164748e-02	1.088
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	8.164748e-02	1.088
Degradation of CRY and PER proteins	R-HSA-9932298	8.164748e-02	1.088
Negative regulation of MAPK pathway	R-HSA-5675221	8.164748e-02	1.088
PERK regulates gene expression	R-HSA-381042	8.285480e-02	1.082
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	8.285480e-02	1.082
Termination of translesion DNA synthesis	R-HSA-5656169	8.287361e-02	1.082
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	8.287361e-02	1.082
Impaired BRCA2 binding to RAD51	R-HSA-9709570	8.287361e-02	1.082
Negative regulation of FGFR4 signaling	R-HSA-5654733	8.287361e-02	1.082
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	8.357633e-02	1.078
Hedgehog 'on' state	R-HSA-5632684	8.357633e-02	1.078
Cellular responses to mechanical stimuli	R-HSA-9855142	8.485830e-02	1.071
Constitutive Signaling by EGFRvIII	R-HSA-5637810	8.773988e-02	1.057
Signaling by EGFRvIII in Cancer	R-HSA-5637812	8.773988e-02	1.057
PI3K events in ERBB2 signaling	R-HSA-1963642	8.773988e-02	1.057
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	8.773988e-02	1.057
Regulation of FZD by ubiquitination	R-HSA-4641263	8.773988e-02	1.057
RNA Polymerase I Transcription Initiation	R-HSA-73762	8.962135e-02	1.048
Nuclear events mediated by NFE2L2	R-HSA-9759194	8.977268e-02	1.047
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	9.104055e-02	1.041
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	9.163591e-02	1.038
RNA Polymerase III Transcription	R-HSA-74158	9.163591e-02	1.038
Vif-mediated degradation of APOBEC3G	R-HSA-180585	9.163591e-02	1.038
Signaling by MET	R-HSA-6806834	9.166396e-02	1.038
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	9.177506e-02	1.037
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	9.177506e-02	1.037
Recycling of eIF2:GDP	R-HSA-72731	9.185712e-02	1.037
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	9.185712e-02	1.037
RNA Polymerase III Transcription Initiation	R-HSA-76046	9.260526e-02	1.033
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	9.260526e-02	1.033
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	9.280406e-02	1.032
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	9.280406e-02	1.032
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	9.280406e-02	1.032
IRAK1 recruits IKK complex	R-HSA-937039	9.280406e-02	1.032
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	9.280406e-02	1.032
MET interacts with TNS proteins	R-HSA-8875513	9.961337e-02	1.002
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	9.961337e-02	1.002
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	9.961337e-02	1.002
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	9.961337e-02	1.002
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	9.961337e-02	1.002
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	9.961337e-02	1.002
MET activates PTPN11	R-HSA-8865999	9.961337e-02	1.002
Drug resistance of FLT3 mutants	R-HSA-9702506	1.006946e-01	0.997
Drug resistance of KIT mutants	R-HSA-9669937	1.006946e-01	0.997
KIT mutants bind TKIs	R-HSA-9669921	1.006946e-01	0.997
FLT3 mutants bind TKIs	R-HSA-9702509	1.006946e-01	0.997
ponatinib-resistant FLT3 mutants	R-HSA-9702614	1.006946e-01	0.997
Imatinib-resistant KIT mutants	R-HSA-9669917	1.006946e-01	0.997
tandutinib-resistant FLT3 mutants	R-HSA-9702636	1.006946e-01	0.997
KW2449-resistant FLT3 mutants	R-HSA-9702569	1.006946e-01	0.997
lestaurtinib-resistant FLT3 mutants	R-HSA-9702596	1.006946e-01	0.997
crenolanib-resistant FLT3 mutants	R-HSA-9702581	1.006946e-01	0.997
Dasatinib-resistant KIT mutants	R-HSA-9669914	1.006946e-01	0.997
linifanib-resistant FLT3 mutants	R-HSA-9702998	1.006946e-01	0.997
sunitinib-resistant FLT3 mutants	R-HSA-9702632	1.006946e-01	0.997
Sorafenib-resistant KIT mutants	R-HSA-9669936	1.006946e-01	0.997
Regorafenib-resistant KIT mutants	R-HSA-9669929	1.006946e-01	0.997
tamatinib-resistant FLT3 mutants	R-HSA-9703009	1.006946e-01	0.997
quizartinib-resistant FLT3 mutants	R-HSA-9702620	1.006946e-01	0.997
pexidartinib-resistant FLT3 mutants	R-HSA-9702605	1.006946e-01	0.997
gilteritinib-resistant FLT3 mutants	R-HSA-9702590	1.006946e-01	0.997
Sunitinib-resistant KIT mutants	R-HSA-9669934	1.006946e-01	0.997
semaxanib-resistant FLT3 mutants	R-HSA-9702577	1.006946e-01	0.997
sorafenib-resistant FLT3 mutants	R-HSA-9702624	1.006946e-01	0.997
Masitinib-resistant KIT mutants	R-HSA-9669924	1.006946e-01	0.997
Nilotinib-resistant KIT mutants	R-HSA-9669926	1.006946e-01	0.997
midostaurin-resistant FLT3 mutants	R-HSA-9702600	1.006946e-01	0.997
Ovarian tumor domain proteases	R-HSA-5689896	1.009309e-01	0.996
Degradation of AXIN	R-HSA-4641257	1.009309e-01	0.996
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	1.009309e-01	0.996
GAB1 signalosome	R-HSA-180292	1.009333e-01	0.996
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	1.009333e-01	0.996
Activation of NF-kappaB in B cells	R-HSA-1169091	1.027187e-01	0.988
Trafficking of AMPA receptors	R-HSA-399719	1.029463e-01	0.987
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	1.029463e-01	0.987
Evasion by RSV of host interferon responses	R-HSA-9833109	1.029463e-01	0.987
Deadenylation of mRNA	R-HSA-429947	1.033877e-01	0.986
CD209 (DC-SIGN) signaling	R-HSA-5621575	1.033877e-01	0.986
G1 Phase	R-HSA-69236	1.068956e-01	0.971
Cyclin D associated events in G1	R-HSA-69231	1.068956e-01	0.971
Membrane binding and targetting of GAG proteins	R-HSA-174490	1.092820e-01	0.961
RIPK1-mediated regulated necrosis	R-HSA-5213460	1.107335e-01	0.956
Downstream TCR signaling	R-HSA-202424	1.118625e-01	0.951
Response of endothelial cells to shear stress	R-HSA-9860931	1.120046e-01	0.951
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.127105e-01	0.948
Signaling by MRAS-complex mutants	R-HSA-9660537	1.134656e-01	0.945
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	1.134656e-01	0.945
G0 and Early G1	R-HSA-1538133	1.138853e-01	0.944
G1/S Transition	R-HSA-69206	1.160506e-01	0.935
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	1.161875e-01	0.935
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	1.185387e-01	0.926
Transcriptional regulation by RUNX3	R-HSA-8878159	1.185794e-01	0.926
Regulation of PTEN stability and activity	R-HSA-8948751	1.199790e-01	0.921
Signaling by WNT	R-HSA-195721	1.219524e-01	0.914
Regulation of RUNX2 expression and activity	R-HSA-8939902	1.225528e-01	0.912
Diseases of Telomere Maintenance	R-HSA-9673013	1.912551e-01	0.718
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	1.912551e-01	0.718
Drug-mediated inhibition of MET activation	R-HSA-9734091	1.912551e-01	0.718
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.912551e-01	0.718
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.912551e-01	0.718
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	1.912551e-01	0.718
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.912551e-01	0.718
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function	R-HSA-9645722	1.912551e-01	0.718
RPIA deficiency: failed conversion of R5P to RU5P	R-HSA-5659996	1.912551e-01	0.718
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)	R-HSA-5619043	1.912551e-01	0.718
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	1.912551e-01	0.718
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	1.912551e-01	0.718
RPIA deficiency: failed conversion of RU5P to R5P	R-HSA-6791461	1.912551e-01	0.718
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.912551e-01	0.718
TICAM1 deficiency - HSE	R-HSA-5602566	1.912551e-01	0.718
FLT3 signaling through SRC family kinases	R-HSA-9706374	1.341305e-01	0.872
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	1.341305e-01	0.872
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	1.341305e-01	0.872
NADE modulates death signalling	R-HSA-205025	1.341305e-01	0.872
PLCG1 events in ERBB2 signaling	R-HSA-1251932	1.341305e-01	0.872
IRS activation	R-HSA-74713	1.708282e-01	0.767
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	1.708282e-01	0.767
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	1.708282e-01	0.767
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	1.708282e-01	0.767
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	1.367792e-01	0.864
Regulated proteolysis of p75NTR	R-HSA-193692	1.367792e-01	0.864
Phosphorylation of Emi1	R-HSA-176417	2.089179e-01	0.680
Noncanonical activation of NOTCH3	R-HSA-9017802	2.089179e-01	0.680
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	2.089179e-01	0.680
MET activates RAP1 and RAC1	R-HSA-8875555	1.615535e-01	0.792
2-LTR circle formation	R-HSA-164843	1.615535e-01	0.792
Signaling by LTK in cancer	R-HSA-9842640	2.477478e-01	0.606
Autointegration results in viral DNA circles	R-HSA-177539	2.477478e-01	0.606
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	1.655425e-01	0.781
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	1.655425e-01	0.781
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	2.145115e-01	0.669
Condensation of Prometaphase Chromosomes	R-HSA-2514853	2.145115e-01	0.669
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	2.145115e-01	0.669
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	2.145115e-01	0.669
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	1.458972e-01	0.836
Disorders of Developmental Biology	R-HSA-9675151	1.862232e-01	0.730
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	1.625117e-01	0.789
RNA Polymerase I Transcription Termination	R-HSA-73863	1.424828e-01	0.846
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	1.424828e-01	0.846
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	1.424828e-01	0.846
FGFR2 alternative splicing	R-HSA-6803529	1.798418e-01	0.745
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	1.798418e-01	0.745
HIV elongation arrest and recovery	R-HSA-167287	1.568360e-01	0.805
Pausing and recovery of HIV elongation	R-HSA-167290	1.568360e-01	0.805
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	1.978227e-01	0.704
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	1.318235e-01	0.880
PRC2 methylates histones and DNA	R-HSA-212300	1.769265e-01	0.752
HDACs deacetylate histones	R-HSA-3214815	1.387377e-01	0.858
Regulation of RAS by GAPs	R-HSA-5658442	1.688664e-01	0.772
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	2.205381e-01	0.657
Nuclear signaling by ERBB4	R-HSA-1251985	2.358592e-01	0.627
HIV Transcription Elongation	R-HSA-167169	2.358592e-01	0.627
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	2.358592e-01	0.627
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	2.358592e-01	0.627
Signaling by ERBB4	R-HSA-1236394	1.685967e-01	0.773
Post-translational protein phosphorylation	R-HSA-8957275	1.896898e-01	0.722
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	2.157584e-01	0.666
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	1.331620e-01	0.876
Early Phase of HIV Life Cycle	R-HSA-162594	1.458972e-01	0.836
mRNA Capping	R-HSA-72086	1.717912e-01	0.765
FLT3 Signaling	R-HSA-9607240	1.430863e-01	0.844
Activation of the pre-replicative complex	R-HSA-68962	1.873082e-01	0.727
Integrin signaling	R-HSA-354192	1.254077e-01	0.902
NoRC negatively regulates rRNA expression	R-HSA-427413	2.235602e-01	0.651
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	2.163872e-01	0.665
RET signaling	R-HSA-8853659	1.769265e-01	0.752
Platelet Aggregation (Plug Formation)	R-HSA-76009	2.058944e-01	0.686
Toxicity of botulinum toxin type G (botG)	R-HSA-5250989	1.708282e-01	0.767
PI3K/AKT activation	R-HSA-198203	1.615535e-01	0.792
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	2.477478e-01	0.606
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	2.477478e-01	0.606
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	1.625117e-01	0.789
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	1.798418e-01	0.745
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	1.501273e-01	0.824
RNA Polymerase I Transcription	R-HSA-73864	1.330878e-01	0.876
Degradation of beta-catenin by the destruction complex	R-HSA-195253	2.121992e-01	0.673
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	1.501273e-01	0.824
Generation of second messenger molecules	R-HSA-202433	1.318235e-01	0.880
CREB phosphorylation	R-HSA-199920	2.477478e-01	0.606
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	1.862232e-01	0.730
RNA Polymerase I Promoter Clearance	R-HSA-73854	1.882909e-01	0.725
MyD88-independent TLR4 cascade	R-HSA-166166	2.311048e-01	0.636
Signaling by FGFR1 in disease	R-HSA-5655302	1.548073e-01	0.810
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	1.287687e-01	0.890
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	2.311048e-01	0.636
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	1.865634e-01	0.729
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	2.163872e-01	0.665
Neurodegenerative Diseases	R-HSA-8863678	2.163872e-01	0.665
Activation and oligomerization of BAK protein	R-HSA-111452	1.912551e-01	0.718
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.424828e-01	0.846
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	1.254077e-01	0.902
Signal transduction by L1	R-HSA-445144	1.300593e-01	0.886
Developmental Cell Lineages	R-HSA-9734767	1.569458e-01	0.804
Aryl hydrocarbon receptor signalling	R-HSA-8937144	2.089179e-01	0.680
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	1.269640e-01	0.896
Mitochondrial calcium ion transport	R-HSA-8949215	1.625117e-01	0.789
Diseases of programmed cell death	R-HSA-9645723	1.572969e-01	0.803
Ca2+ pathway	R-HSA-4086398	2.469786e-01	0.607
Ion homeostasis	R-HSA-5578775	1.486609e-01	0.828
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	2.477478e-01	0.606
Regulation of NFE2L2 gene expression	R-HSA-9818749	2.477478e-01	0.606
FGFR1 mutant receptor activation	R-HSA-1839124	2.367925e-01	0.626
Protein methylation	R-HSA-8876725	1.457526e-01	0.836
Adaptive Immune System	R-HSA-1280218	2.094401e-01	0.679
Signaling by FGFR2	R-HSA-5654738	1.497080e-01	0.825
Cellular response to chemical stress	R-HSA-9711123	2.318987e-01	0.635
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	2.315956e-01	0.635
Signaling by FGFR4	R-HSA-5654743	1.795517e-01	0.746
Activation, translocation and oligomerization of BAX	R-HSA-114294	1.912551e-01	0.718
Formation of editosomes by ADAR proteins	R-HSA-77042	1.912551e-01	0.718
Inhibition of PKR	R-HSA-169131	1.912551e-01	0.718
MTF1 activates gene expression	R-HSA-5660489	1.341305e-01	0.872
Unwinding of DNA	R-HSA-176974	1.367792e-01	0.864
Bicarbonate transporters	R-HSA-425381	1.875438e-01	0.727
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	2.145115e-01	0.669
Signaling by LTK	R-HSA-9842663	2.422274e-01	0.616
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	2.297995e-01	0.639
Negative regulation of FGFR2 signaling	R-HSA-5654727	1.501273e-01	0.824
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	1.501273e-01	0.824
Diseases associated with the TLR signaling cascade	R-HSA-5602358	2.358592e-01	0.627
Diseases of Immune System	R-HSA-5260271	2.358592e-01	0.627
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	1.479882e-01	0.830
Resolution of Abasic Sites (AP sites)	R-HSA-73933	1.430863e-01	0.844
Signaling by FGFR3	R-HSA-5654741	2.058944e-01	0.686
Negative regulation of FGFR1 signaling	R-HSA-5654726	1.254077e-01	0.902
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	1.325095e-01	0.878
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	1.862232e-01	0.730
Platelet activation, signaling and aggregation	R-HSA-76002	2.152149e-01	0.667
Regulation of CDH11 gene transcription	R-HSA-9762293	1.367792e-01	0.864
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	2.367925e-01	0.626
Signaling by Nuclear Receptors	R-HSA-9006931	1.390721e-01	0.857
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	2.336488e-01	0.631
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	2.089179e-01	0.680
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	2.055869e-01	0.687
Antigen processing-Cross presentation	R-HSA-1236975	1.452592e-01	0.838
G alpha (12/13) signalling events	R-HSA-416482	2.089953e-01	0.680
Generic Transcription Pathway	R-HSA-212436	1.940104e-01	0.712
Formation of definitive endoderm	R-HSA-9823730	1.300593e-01	0.886
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	1.910390e-01	0.719
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	2.439518e-01	0.613
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	2.198545e-01	0.658
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	1.798418e-01	0.745
Ion transport by P-type ATPases	R-HSA-936837	2.396275e-01	0.620
Intrinsic Pathway for Apoptosis	R-HSA-109606	1.486609e-01	0.828
Regulation of MITF-M dependent genes involved in invasion	R-HSA-9854909	1.708282e-01	0.767
Integration of viral DNA into host genomic DNA	R-HSA-175567	2.477478e-01	0.606
Signaling by PDGFR in disease	R-HSA-9671555	1.625117e-01	0.789
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	1.254077e-01	0.902
Potential therapeutics for SARS	R-HSA-9679191	1.882896e-01	0.725
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	1.254077e-01	0.902
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	1.632798e-01	0.787
Diseases of DNA repair	R-HSA-9675135	2.196075e-01	0.658
TP53 Regulates Metabolic Genes	R-HSA-5628897	1.436520e-01	0.843
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	1.363356e-01	0.865
Assembly Of The HIV Virion	R-HSA-175474	1.625117e-01	0.789
Plasma lipoprotein clearance	R-HSA-8964043	2.205381e-01	0.657
Inositol phosphate metabolism	R-HSA-1483249	1.754023e-01	0.756
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	1.615535e-01	0.792
Interleukin-7 signaling	R-HSA-1266695	2.354660e-01	0.628
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	1.625117e-01	0.789
ABC transporter disorders	R-HSA-5619084	2.089953e-01	0.680
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	1.708282e-01	0.767
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	1.458972e-01	0.836
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	1.862232e-01	0.730
Regulation of NF-kappa B signaling	R-HSA-9758274	1.655425e-01	0.781
Signaling by Interleukins	R-HSA-449147	2.293037e-01	0.640
Glycogen storage diseases	R-HSA-3229121	2.076805e-01	0.683
Assembly of Viral Components at the Budding Site	R-HSA-168316	1.708282e-01	0.767
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	2.479921e-01	0.606
CLEC7A (Dectin-1) signaling	R-HSA-5607764	2.521304e-01	0.598
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	2.524656e-01	0.598
Impaired BRCA2 binding to PALB2	R-HSA-9709603	2.524656e-01	0.598
Rap1 signalling	R-HSA-392517	2.524656e-01	0.598
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	2.549892e-01	0.593
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	2.549892e-01	0.593
Signaling by FGFR in disease	R-HSA-1226099	2.590075e-01	0.587
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	2.704756e-01	0.568
CD28 dependent Vav1 pathway	R-HSA-389359	2.704756e-01	0.568
Formation of axial mesoderm	R-HSA-9796292	2.704756e-01	0.568
Non-integrin membrane-ECM interactions	R-HSA-3000171	2.712301e-01	0.567
Iron uptake and transport	R-HSA-917937	2.712301e-01	0.567
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	2.717609e-01	0.566
Signaling by NOTCH2	R-HSA-1980145	2.717609e-01	0.566
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	2.717609e-01	0.566
NPAS4 regulates expression of target genes	R-HSA-9768919	2.717609e-01	0.566
Interactions of Tat with host cellular proteins	R-HSA-176034	2.727010e-01	0.564
Signaling by juxtamembrane domain KIT mutants	R-HSA-9669935	2.727010e-01	0.564
NFG and proNGF binds to p75NTR	R-HSA-205017	2.727010e-01	0.564
Signaling by extracellular domain mutants of KIT	R-HSA-9680187	2.727010e-01	0.564
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	2.727010e-01	0.564
PTEN Loss of Function in Cancer	R-HSA-5674404	2.727010e-01	0.564
Signaling by kinase domain mutants of KIT	R-HSA-9669933	2.727010e-01	0.564
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.727010e-01	0.564
TRAF3 deficiency - HSE	R-HSA-5602571	2.727010e-01	0.564
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.727010e-01	0.564
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	R-HSA-5083628	2.727010e-01	0.564
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	2.727010e-01	0.564
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	2.727010e-01	0.564
Transport of connexins along the secretory pathway	R-HSA-190827	2.727010e-01	0.564
Oligomerization of connexins into connexons	R-HSA-190704	2.727010e-01	0.564
Breakdown of the nuclear lamina	R-HSA-352238	2.727010e-01	0.564
Signaling by NTRK2 (TRKB)	R-HSA-9006115	2.748865e-01	0.561
Insulin processing	R-HSA-264876	2.748865e-01	0.561
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	2.748865e-01	0.561
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	2.755662e-01	0.560
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	2.755662e-01	0.560
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	2.755662e-01	0.560
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	2.755662e-01	0.560
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	2.755662e-01	0.560
Glycogen synthesis	R-HSA-3322077	2.755662e-01	0.560
Ca-dependent events	R-HSA-111996	2.836939e-01	0.547
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	2.836939e-01	0.547
Deadenylation-dependent mRNA decay	R-HSA-429914	2.852007e-01	0.545
MECP2 regulates transcription factors	R-HSA-9022707	2.867828e-01	0.542
Activated NTRK2 signals through CDK5	R-HSA-9032845	2.867828e-01	0.542
MET activates PI3K/AKT signaling	R-HSA-8851907	2.867828e-01	0.542
RUNX3 regulates WNT signaling	R-HSA-8951430	2.867828e-01	0.542
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	2.867828e-01	0.542
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	2.867828e-01	0.542
TRIF-mediated programmed cell death	R-HSA-2562578	2.867828e-01	0.542
SOS-mediated signalling	R-HSA-112412	2.867828e-01	0.542
Activated NTRK3 signals through PI3K	R-HSA-9603381	2.867828e-01	0.542
PTK6 Expression	R-HSA-8849473	2.867828e-01	0.542
CHL1 interactions	R-HSA-447041	2.867828e-01	0.542
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	2.867828e-01	0.542
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	2.867828e-01	0.542
Uptake and function of diphtheria toxin	R-HSA-5336415	2.867828e-01	0.542
Regulated Necrosis	R-HSA-5218859	2.912992e-01	0.536
Maternal to zygotic transition (MZT)	R-HSA-9816359	2.918768e-01	0.535
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	2.925627e-01	0.534
Reproduction	R-HSA-1474165	2.937392e-01	0.532
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	2.950885e-01	0.530
Formation of the Early Elongation Complex	R-HSA-113418	2.950885e-01	0.530
Basigin interactions	R-HSA-210991	2.989921e-01	0.524
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	2.989921e-01	0.524
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	2.989921e-01	0.524
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	2.989921e-01	0.524
CRMPs in Sema3A signaling	R-HSA-399956	2.990549e-01	0.524
Signal regulatory protein family interactions	R-HSA-391160	2.990549e-01	0.524
Defective pyroptosis	R-HSA-9710421	3.001435e-01	0.523
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	3.046759e-01	0.516
Neurexins and neuroligins	R-HSA-6794361	3.078403e-01	0.512
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	3.078403e-01	0.512
Lysosome Vesicle Biogenesis	R-HSA-432720	3.078634e-01	0.512
Calmodulin induced events	R-HSA-111933	3.078634e-01	0.512
CaM pathway	R-HSA-111997	3.078634e-01	0.512
Nuclear Receptor transcription pathway	R-HSA-383280	3.089059e-01	0.510
Circadian clock	R-HSA-9909396	3.130354e-01	0.504
MAP kinase activation	R-HSA-450294	3.136787e-01	0.504
Regulation of gene expression in beta cells	R-HSA-210745	3.155264e-01	0.501
Signaling by CSF3 (G-CSF)	R-HSA-9674555	3.155264e-01	0.501
Type I hemidesmosome assembly	R-HSA-446107	3.255883e-01	0.487
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	3.255883e-01	0.487
MET receptor recycling	R-HSA-8875656	3.255883e-01	0.487
Toxicity of botulinum toxin type B (botB)	R-HSA-5250958	3.255883e-01	0.487
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	3.255883e-01	0.487
ROBO receptors bind AKAP5	R-HSA-9010642	3.255883e-01	0.487
IRF3-mediated induction of type I IFN	R-HSA-3270619	3.277804e-01	0.484
Fanconi Anemia Pathway	R-HSA-6783310	3.335838e-01	0.477
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	3.347054e-01	0.475
Class I MHC mediated antigen processing & presentation	R-HSA-983169	3.349881e-01	0.475
MET promotes cell motility	R-HSA-8875878	3.447151e-01	0.463
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	3.459490e-01	0.461
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	3.459490e-01	0.461
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	3.459490e-01	0.461
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	R-HSA-5083629	3.459490e-01	0.461
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.459490e-01	0.461
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	R-HSA-5083633	3.459490e-01	0.461
mRNA Editing: A to I Conversion	R-HSA-75064	3.459490e-01	0.461
C6 deamination of adenosine	R-HSA-75102	3.459490e-01	0.461
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	3.459490e-01	0.461
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis	R-HSA-9708296	3.459490e-01	0.461
ATF6B (ATF6-beta) activates chaperones	R-HSA-8874177	3.459490e-01	0.461
Signaling by KIT in disease	R-HSA-9669938	3.464045e-01	0.460
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	3.464045e-01	0.460
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	3.464045e-01	0.460
mRNA Splicing - Minor Pathway	R-HSA-72165	3.505030e-01	0.455
Regulation of pyruvate metabolism	R-HSA-9861718	3.505030e-01	0.455
Prolonged ERK activation events	R-HSA-169893	3.564842e-01	0.448
WNT5A-dependent internalization of FZD4	R-HSA-5099900	3.564842e-01	0.448
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	3.568457e-01	0.448
Telomere Maintenance	R-HSA-157579	3.625475e-01	0.441
Signaling by ALK	R-HSA-201556	3.633050e-01	0.440
ARMS-mediated activation	R-HSA-170984	3.638147e-01	0.439
Lipophagy	R-HSA-9613354	3.638147e-01	0.439
WNT mediated activation of DVL	R-HSA-201688	3.638147e-01	0.439
Hypusine synthesis from eIF5A-lysine	R-HSA-204626	3.638147e-01	0.439
5-Phosphoribose 1-diphosphate biosynthesis	R-HSA-73843	3.638147e-01	0.439
MASTL Facilitates Mitotic Progression	R-HSA-2465910	3.638147e-01	0.439
Calcineurin activates NFAT	R-HSA-2025928	3.638147e-01	0.439
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	3.638147e-01	0.439
Inactivation of CDC42 and RAC1	R-HSA-428543	3.638147e-01	0.439
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	3.638147e-01	0.439
Respiratory syncytial virus genome replication	R-HSA-9834752	3.638147e-01	0.439
Interleukin-1 processing	R-HSA-448706	3.638147e-01	0.439
Butyrophilin (BTN) family interactions	R-HSA-8851680	3.638147e-01	0.439
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	3.675082e-01	0.435
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	3.701971e-01	0.432
Syndecan interactions	R-HSA-3000170	3.701971e-01	0.432
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	3.701971e-01	0.432
Signaling by FGFR1	R-HSA-5654736	3.703051e-01	0.431
Cellular response to hypoxia	R-HSA-1234174	3.721659e-01	0.429
Negative regulation of the PI3K/AKT network	R-HSA-199418	3.733581e-01	0.428
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	3.742457e-01	0.427
Pre-NOTCH Transcription and Translation	R-HSA-1912408	3.744885e-01	0.427
Signaling by FGFR	R-HSA-190236	3.746013e-01	0.426
DNA strand elongation	R-HSA-69190	3.776004e-01	0.423
Selenoamino acid metabolism	R-HSA-2408522	3.799997e-01	0.420
Inhibition of DNA recombination at telomere	R-HSA-9670095	3.819440e-01	0.418
Glycogen metabolism	R-HSA-8982491	3.819440e-01	0.418
Co-stimulation by CD28	R-HSA-389356	3.845651e-01	0.415
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	3.846720e-01	0.415
SHC1 events in ERBB4 signaling	R-HSA-1250347	3.850154e-01	0.415
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	3.850154e-01	0.415
Synthesis of PG	R-HSA-1483148	3.850154e-01	0.415
TRAF6 mediated NF-kB activation	R-HSA-933542	3.939278e-01	0.405
Nuclear RNA decay	R-HSA-9930044	3.983386e-01	0.400
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	3.983386e-01	0.400
Protein-protein interactions at synapses	R-HSA-6794362	4.006561e-01	0.397
Binding and entry of HIV virion	R-HSA-173107	4.011855e-01	0.397
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	4.011855e-01	0.397
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	4.011855e-01	0.397
EGFR Transactivation by Gastrin	R-HSA-2179392	4.011855e-01	0.397
Signal attenuation	R-HSA-74749	4.011855e-01	0.397
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	4.011855e-01	0.397
Signaling by Leptin	R-HSA-2586552	4.011855e-01	0.397
Disorders of transmembrane transporters	R-HSA-5619115	4.015336e-01	0.396
Signaling by NTRKs	R-HSA-166520	4.018134e-01	0.396
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	4.019628e-01	0.396
Interleukin-1 signaling	R-HSA-9020702	4.110083e-01	0.386
Axonal growth stimulation	R-HSA-209563	4.118239e-01	0.385
Defective ABCC2 causes DJS	R-HSA-5679001	4.118239e-01	0.385
MET activates STAT3	R-HSA-8875791	4.118239e-01	0.385
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	4.118239e-01	0.385
Histamine receptors	R-HSA-390650	4.118239e-01	0.385
Transmission across Chemical Synapses	R-HSA-112315	4.169571e-01	0.380
Tight junction interactions	R-HSA-420029	4.175152e-01	0.379
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	4.175152e-01	0.379
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	4.175152e-01	0.379
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	4.190044e-01	0.378
Translation of Structural Proteins	R-HSA-9683701	4.191989e-01	0.378
Meiotic recombination	R-HSA-912446	4.357193e-01	0.361
Formation of the posterior neural plate	R-HSA-9832991	4.374852e-01	0.359
Synthesis of PI	R-HSA-1483226	4.374852e-01	0.359
Ionotropic activity of kainate receptors	R-HSA-451306	4.374852e-01	0.359
vRNP Assembly	R-HSA-192905	4.374852e-01	0.359
Signaling by FLT3 fusion proteins	R-HSA-9703465	4.408845e-01	0.356
Suppression of phagosomal maturation	R-HSA-9637687	4.408845e-01	0.356
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	4.410406e-01	0.356
RNA Polymerase III Transcription Termination	R-HSA-73980	4.410406e-01	0.356
Polo-like kinase mediated events	R-HSA-156711	4.410406e-01	0.356
Interleukin-17 signaling	R-HSA-448424	4.463018e-01	0.350
Signaling by NTRK1 (TRKA)	R-HSA-187037	4.500631e-01	0.347
Protein localization	R-HSA-9609507	4.516881e-01	0.345
RNA Polymerase I Promoter Escape	R-HSA-73772	4.526619e-01	0.344
Signaling by SCF-KIT	R-HSA-1433557	4.561563e-01	0.341
Response of Mtb to phagocytosis	R-HSA-9637690	4.561563e-01	0.341
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	4.567940e-01	0.340
Activation of HOX genes during differentiation	R-HSA-5619507	4.596836e-01	0.338
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	4.596836e-01	0.338
Signalling to ERKs	R-HSA-187687	4.599116e-01	0.337
CD28 dependent PI3K/Akt signaling	R-HSA-389357	4.639675e-01	0.334
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	4.682810e-01	0.329
Signaling by FGFR2 IIIa TM	R-HSA-8851708	4.683150e-01	0.329
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	4.683150e-01	0.329
The NLRP3 inflammasome	R-HSA-844456	4.683150e-01	0.329
Maturation of nucleoprotein	R-HSA-9694631	4.683150e-01	0.329
STING mediated induction of host immune responses	R-HSA-1834941	4.683150e-01	0.329
GRB7 events in ERBB2 signaling	R-HSA-1306955	4.710675e-01	0.327
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	4.710675e-01	0.327
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	4.710675e-01	0.327
Defective LFNG causes SCDO3	R-HSA-5083630	4.710675e-01	0.327
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	4.710675e-01	0.327
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	4.710675e-01	0.327
Toxicity of tetanus toxin (tetX)	R-HSA-5250982	4.710675e-01	0.327
PI3K events in ERBB4 signaling	R-HSA-1250342	4.725506e-01	0.326
Sensing of DNA Double Strand Breaks	R-HSA-5693548	4.725506e-01	0.326
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	4.725506e-01	0.326
Reduction of cytosolic Ca++ levels	R-HSA-418359	4.725506e-01	0.326
Activation of RAC1	R-HSA-428540	4.725506e-01	0.326
Proteasome assembly	R-HSA-9907900	4.744312e-01	0.324
Netrin-1 signaling	R-HSA-373752	4.744312e-01	0.324
Base Excision Repair	R-HSA-73884	4.802953e-01	0.318
Telomere Extension By Telomerase	R-HSA-171319	4.867029e-01	0.313
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	4.867029e-01	0.313
MyD88 cascade initiated on plasma membrane	R-HSA-975871	4.884561e-01	0.311
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	4.884561e-01	0.311
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	4.884561e-01	0.311
DAG and IP3 signaling	R-HSA-1489509	4.925254e-01	0.308
VxPx cargo-targeting to cilium	R-HSA-5620916	4.949763e-01	0.305
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	4.949763e-01	0.305
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	4.955163e-01	0.305
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	5.062623e-01	0.296
Repression of WNT target genes	R-HSA-4641265	5.062623e-01	0.296
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	5.062623e-01	0.296
Disorders of Nervous System Development	R-HSA-9697154	5.062623e-01	0.296
Pervasive developmental disorders	R-HSA-9005895	5.062623e-01	0.296
Polymerase switching	R-HSA-69091	5.062623e-01	0.296
Leading Strand Synthesis	R-HSA-69109	5.062623e-01	0.296
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	5.062623e-01	0.296
Scavenging by Class F Receptors	R-HSA-3000484	5.062623e-01	0.296
AKT phosphorylates targets in the cytosol	R-HSA-198323	5.062623e-01	0.296
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	5.078526e-01	0.294
DNA methylation	R-HSA-5334118	5.090361e-01	0.293
DARPP-32 events	R-HSA-180024	5.090361e-01	0.293
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	5.090361e-01	0.293
SLC-mediated transport of inorganic anions	R-HSA-9958790	5.195290e-01	0.284
MyD88 dependent cascade initiated on endosome	R-HSA-975155	5.197375e-01	0.284
TNFR1-induced proapoptotic signaling	R-HSA-5357786	5.209513e-01	0.283
MyD88 deficiency (TLR2/4)	R-HSA-5602498	5.209513e-01	0.283
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	5.209513e-01	0.283
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	5.209513e-01	0.283
Post-translational protein modification	R-HSA-597592	5.210035e-01	0.283
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	5.243469e-01	0.280
G2 Phase	R-HSA-68911	5.243469e-01	0.280
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	5.243469e-01	0.280
Defective F9 activation	R-HSA-9673221	5.243469e-01	0.280
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	5.243469e-01	0.280
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	5.243469e-01	0.280
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	5.243469e-01	0.280
PTK6 Down-Regulation	R-HSA-8849472	5.243469e-01	0.280
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	5.243469e-01	0.280
Reelin signalling pathway	R-HSA-8866376	5.243469e-01	0.280
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	5.243469e-01	0.280
Muscarinic acetylcholine receptors	R-HSA-390648	5.243469e-01	0.280
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	5.243469e-01	0.280
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	5.243469e-01	0.280
SMAC (DIABLO) binds to IAPs	R-HSA-111463	5.243469e-01	0.280
DAP12 signaling	R-HSA-2424491	5.309187e-01	0.275
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	5.309187e-01	0.275
Interleukin-37 signaling	R-HSA-9008059	5.309187e-01	0.275
Signaling by NOTCH1	R-HSA-1980143	5.333961e-01	0.273
Ion channel transport	R-HSA-983712	5.352835e-01	0.271
tRNA processing	R-HSA-72306	5.354802e-01	0.271
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	5.385371e-01	0.269
Frs2-mediated activation	R-HSA-170968	5.385371e-01	0.269
Processing of SMDT1	R-HSA-8949664	5.385371e-01	0.269
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	5.385371e-01	0.269
Replication of the SARS-CoV-1 genome	R-HSA-9682706	5.385371e-01	0.269
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	5.387802e-01	0.269
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	5.387802e-01	0.269
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	5.387802e-01	0.269
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	5.387802e-01	0.269
C-type lectin receptors (CLRs)	R-HSA-5621481	5.449081e-01	0.264
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	5.461796e-01	0.263
Translation of Structural Proteins	R-HSA-9694635	5.474650e-01	0.262
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	5.481963e-01	0.261
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	5.481963e-01	0.261
Transcriptional regulation by RUNX2	R-HSA-8878166	5.481963e-01	0.261
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	5.625137e-01	0.250
Pre-NOTCH Expression and Processing	R-HSA-1912422	5.663661e-01	0.247
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	5.663661e-01	0.247
Extension of Telomeres	R-HSA-180786	5.669837e-01	0.246
Peroxisomal protein import	R-HSA-9033241	5.669837e-01	0.246
Signaling by FGFR4 in disease	R-HSA-5655291	5.693226e-01	0.245
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	5.693226e-01	0.245
Neurotoxicity of clostridium toxins	R-HSA-168799	5.706129e-01	0.244
Plus-strand DNA synthesis	R-HSA-164525	5.722624e-01	0.242
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	5.722624e-01	0.242
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	5.722624e-01	0.242
PTK6 Regulates Cell Cycle	R-HSA-8849470	5.722624e-01	0.242
Signaling by RNF43 mutants	R-HSA-5340588	5.722624e-01	0.242
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	5.722624e-01	0.242
Pentose phosphate pathway disease	R-HSA-6791465	5.722624e-01	0.242
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	5.722624e-01	0.242
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	5.722624e-01	0.242
Ceramide signalling	R-HSA-193681	5.722624e-01	0.242
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	5.722624e-01	0.242
Negative feedback regulation of MAPK pathway	R-HSA-5674499	5.722624e-01	0.242
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	5.722624e-01	0.242
Orexin and neuropeptides FF and QRFP bind to their respective receptors	R-HSA-389397	5.722624e-01	0.242
CLEC7A/inflammasome pathway	R-HSA-5660668	5.722624e-01	0.242
Sodium-coupled phosphate cotransporters	R-HSA-427652	5.722624e-01	0.242
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	5.731698e-01	0.242
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	5.761593e-01	0.239
PI3K Cascade	R-HSA-109704	5.792885e-01	0.237
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	5.813330e-01	0.236
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	5.813330e-01	0.236
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	5.855536e-01	0.232
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	5.886122e-01	0.230
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	5.934719e-01	0.227
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	5.942134e-01	0.226
Growth hormone receptor signaling	R-HSA-982772	5.942134e-01	0.226
PLC beta mediated events	R-HSA-112043	5.976174e-01	0.224
RNA Polymerase III Chain Elongation	R-HSA-73780	5.985912e-01	0.223
p38MAPK events	R-HSA-171007	5.985912e-01	0.223
Other semaphorin interactions	R-HSA-416700	5.985912e-01	0.223
Formation of the anterior neural plate	R-HSA-9823739	5.985912e-01	0.223
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	5.985912e-01	0.223
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	6.001495e-01	0.222
Gastrulation	R-HSA-9758941	6.009710e-01	0.221
Mitochondrial protein import	R-HSA-1268020	6.125086e-01	0.213
Heme signaling	R-HSA-9707616	6.125086e-01	0.213
Resolution of D-Loop Structures	R-HSA-5693537	6.131897e-01	0.212
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	6.131897e-01	0.212
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	6.136334e-01	0.212
PTK6 promotes HIF1A stabilization	R-HSA-8857538	6.153535e-01	0.211
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	6.153535e-01	0.211
STAT5 Activation	R-HSA-9645135	6.153535e-01	0.211
Erythropoietin activates STAT5	R-HSA-9027283	6.153535e-01	0.211
G2/M DNA replication checkpoint	R-HSA-69478	6.153535e-01	0.211
Uncoating of the HIV Virion	R-HSA-162585	6.153535e-01	0.211
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)	R-HSA-5619070	6.153535e-01	0.211
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	6.153535e-01	0.211
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	6.153535e-01	0.211
MET Receptor Activation	R-HSA-6806942	6.153535e-01	0.211
Neurofascin interactions	R-HSA-447043	6.153535e-01	0.211
Abacavir transmembrane transport	R-HSA-2161517	6.153535e-01	0.211
Lactose synthesis	R-HSA-5653890	6.153535e-01	0.211
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	6.153535e-01	0.211
HDL clearance	R-HSA-8964011	6.153535e-01	0.211
VLDL assembly	R-HSA-8866423	6.153535e-01	0.211
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	6.169533e-01	0.210
Killing mechanisms	R-HSA-9664420	6.263361e-01	0.203
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	6.263361e-01	0.203
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	6.263361e-01	0.203
Activation of SMO	R-HSA-5635838	6.263361e-01	0.203
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	6.263361e-01	0.203
Atorvastatin ADME	R-HSA-9754706	6.263361e-01	0.203
Virus Assembly and Release	R-HSA-168268	6.263361e-01	0.203
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	6.279240e-01	0.202
Interleukin-1 family signaling	R-HSA-446652	6.296063e-01	0.201
NOD1/2 Signaling Pathway	R-HSA-168638	6.323030e-01	0.199
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	6.323030e-01	0.199
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	6.323030e-01	0.199
VEGFR2 mediated cell proliferation	R-HSA-5218921	6.388135e-01	0.195
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	6.413761e-01	0.193
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	6.481373e-01	0.188
G beta:gamma signalling through CDC42	R-HSA-8964616	6.525673e-01	0.185
Processing of Intronless Pre-mRNAs	R-HSA-77595	6.525673e-01	0.185
Acetylcholine regulates insulin secretion	R-HSA-399997	6.525673e-01	0.185
Response to metal ions	R-HSA-5660526	6.525673e-01	0.185
IFNG signaling activates MAPKs	R-HSA-9732724	6.541059e-01	0.184
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	6.541059e-01	0.184
Disinhibition of SNARE formation	R-HSA-114516	6.541059e-01	0.184
DAG1 core M1 glycosylations	R-HSA-8932506	6.541059e-01	0.184
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	6.541059e-01	0.184
VLDL clearance	R-HSA-8964046	6.541059e-01	0.184
LDL remodeling	R-HSA-8964041	6.541059e-01	0.184
Netrin mediated repulsion signals	R-HSA-418886	6.541059e-01	0.184
Cation-coupled Chloride cotransporters	R-HSA-426117	6.541059e-01	0.184
Nef Mediated CD4 Down-regulation	R-HSA-167590	6.541059e-01	0.184
Displacement of DNA glycosylase by APEX1	R-HSA-110357	6.541059e-01	0.184
MET activates PTK2 signaling	R-HSA-8874081	6.597827e-01	0.181
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	6.597827e-01	0.181
Somitogenesis	R-HSA-9824272	6.620054e-01	0.179
Hemostasis	R-HSA-109582	6.638881e-01	0.178
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	6.686590e-01	0.175
G1/S-Specific Transcription	R-HSA-69205	6.686590e-01	0.175
Opioid Signalling	R-HSA-111885	6.746756e-01	0.171
HCMV Late Events	R-HSA-9610379	6.750216e-01	0.171
SLC transporter disorders	R-HSA-5619102	6.756353e-01	0.170
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	6.773081e-01	0.169
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	6.773081e-01	0.169
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	6.773081e-01	0.169
Specification of primordial germ cells	R-HSA-9827857	6.773081e-01	0.169
Replication of the SARS-CoV-2 genome	R-HSA-9694686	6.773081e-01	0.169
Condensation of Prophase Chromosomes	R-HSA-2299718	6.777475e-01	0.169
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	6.791791e-01	0.168
Packaging Of Telomere Ends	R-HSA-171306	6.798566e-01	0.168
Cristae formation	R-HSA-8949613	6.798566e-01	0.168
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	6.798566e-01	0.168
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	6.798566e-01	0.168
RNA Polymerase I Promoter Opening	R-HSA-73728	6.798566e-01	0.168
G-protein mediated events	R-HSA-112040	6.822429e-01	0.166
IRS-mediated signalling	R-HSA-112399	6.866330e-01	0.163
Pyruvate metabolism	R-HSA-70268	6.886996e-01	0.162
Reverse Transcription of HIV RNA	R-HSA-162589	6.889561e-01	0.162
Minus-strand DNA synthesis	R-HSA-164516	6.889561e-01	0.162
phospho-PLA2 pathway	R-HSA-111995	6.889561e-01	0.162
EGFR interacts with phospholipase C-gamma	R-HSA-212718	6.889561e-01	0.162
DAG1 core M2 glycosylations	R-HSA-8932504	6.889561e-01	0.162
Activated NTRK2 signals through PI3K	R-HSA-9028335	6.889561e-01	0.162
Axonal growth inhibition (RHOA activation)	R-HSA-193634	6.889561e-01	0.162
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	6.889561e-01	0.162
Regulation by c-FLIP	R-HSA-3371378	6.889561e-01	0.162
Co-stimulation by ICOS	R-HSA-9927354	6.889561e-01	0.162
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	6.889561e-01	0.162
Adrenoceptors	R-HSA-390696	6.889561e-01	0.162
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	6.889561e-01	0.162
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	6.889561e-01	0.162
TGFBR3 PTM regulation	R-HSA-9839383	6.889561e-01	0.162
Dimerization of procaspase-8	R-HSA-69416	6.889561e-01	0.162
Activated NTRK2 signals through FYN	R-HSA-9032500	6.889561e-01	0.162
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	6.889561e-01	0.162
Interleukin-23 signaling	R-HSA-9020933	6.889561e-01	0.162
Insulin receptor recycling	R-HSA-77387	6.990368e-01	0.155
Phase 0 - rapid depolarisation	R-HSA-5576892	6.990368e-01	0.155
Inflammasomes	R-HSA-622312	6.990368e-01	0.155
Platelet sensitization by LDL	R-HSA-432142	7.005926e-01	0.155
Mismatch Repair	R-HSA-5358508	7.005926e-01	0.155
Apoptotic factor-mediated response	R-HSA-111471	7.005926e-01	0.155
Synaptic adhesion-like molecules	R-HSA-8849932	7.005926e-01	0.155
Nephron development	R-HSA-9831926	7.005926e-01	0.155
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	7.005926e-01	0.155
NGF-stimulated transcription	R-HSA-9031628	7.077359e-01	0.150
Regulation of beta-cell development	R-HSA-186712	7.137454e-01	0.146
Immune System	R-HSA-168256	7.139938e-01	0.146
Platelet calcium homeostasis	R-HSA-418360	7.173304e-01	0.144
Pentose phosphate pathway	R-HSA-71336	7.184057e-01	0.144
RAS processing	R-HSA-9648002	7.184057e-01	0.144
CASP8 activity is inhibited	R-HSA-5218900	7.202968e-01	0.142
p75NTR regulates axonogenesis	R-HSA-193697	7.202968e-01	0.142
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	7.202968e-01	0.142
Activation of the AP-1 family of transcription factors	R-HSA-450341	7.202968e-01	0.142
mRNA Editing	R-HSA-75072	7.202968e-01	0.142
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	7.202968e-01	0.142
Regulation of signaling by NODAL	R-HSA-1433617	7.202968e-01	0.142
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	7.202968e-01	0.142
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	7.202968e-01	0.142
Regulation of NPAS4 gene transcription	R-HSA-9768777	7.202968e-01	0.142
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	7.202968e-01	0.142
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	7.202968e-01	0.142
Pre-NOTCH Processing in Golgi	R-HSA-1912420	7.224629e-01	0.141
PI-3K cascade:FGFR3	R-HSA-5654710	7.224629e-01	0.141
Germ layer formation at gastrulation	R-HSA-9754189	7.224629e-01	0.141
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	7.224629e-01	0.141
Specification of the neural plate border	R-HSA-9834899	7.224629e-01	0.141
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	7.224629e-01	0.141
Other interleukin signaling	R-HSA-449836	7.224629e-01	0.141
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	7.224629e-01	0.141
Amyloid fiber formation	R-HSA-977225	7.263576e-01	0.139
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	7.266806e-01	0.139
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	7.266806e-01	0.139
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	7.266806e-01	0.139
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	7.266806e-01	0.139
Signaling by NOTCH1 in Cancer	R-HSA-2644603	7.266806e-01	0.139
Sphingolipid de novo biosynthesis	R-HSA-1660661	7.266806e-01	0.139
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	7.337062e-01	0.134
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	7.337062e-01	0.134
GABA synthesis, release, reuptake and degradation	R-HSA-888590	7.347489e-01	0.134
Signaling by FGFR2 in disease	R-HSA-5655253	7.357119e-01	0.133
Azathioprine ADME	R-HSA-9748787	7.357119e-01	0.133
IRS-related events triggered by IGF1R	R-HSA-2428928	7.391999e-01	0.131
Formation of paraxial mesoderm	R-HSA-9793380	7.391999e-01	0.131
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	7.429676e-01	0.129
PI-3K cascade:FGFR4	R-HSA-5654720	7.429676e-01	0.129
Formation of ATP by chemiosmotic coupling	R-HSA-163210	7.429676e-01	0.129
Co-inhibition by CTLA4	R-HSA-389513	7.429676e-01	0.129
Common Pathway of Fibrin Clot Formation	R-HSA-140875	7.429676e-01	0.129
Protein hydroxylation	R-HSA-9629569	7.429676e-01	0.129
Creatine metabolism	R-HSA-71288	7.429676e-01	0.129
Asparagine N-linked glycosylation	R-HSA-446203	7.437078e-01	0.129
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	7.483721e-01	0.126
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	7.484813e-01	0.126
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	7.484813e-01	0.126
DNA replication initiation	R-HSA-68952	7.484813e-01	0.126
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	7.484813e-01	0.126
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	7.484813e-01	0.126
MAPK3 (ERK1) activation	R-HSA-110056	7.484813e-01	0.126
Defective factor IX causes hemophilia B	R-HSA-9668250	7.484813e-01	0.126
Metal sequestration by antimicrobial proteins	R-HSA-6799990	7.484813e-01	0.126
Interleukin-27 signaling	R-HSA-9020956	7.484813e-01	0.126
Receptor Mediated Mitophagy	R-HSA-8934903	7.484813e-01	0.126
Maturation of spike protein	R-HSA-9683686	7.484813e-01	0.126
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	7.513039e-01	0.124
NCAM signaling for neurite out-growth	R-HSA-375165	7.513039e-01	0.124
Transcriptional regulation of granulopoiesis	R-HSA-9616222	7.513039e-01	0.124
Signaling by Insulin receptor	R-HSA-74752	7.529572e-01	0.123
Late SARS-CoV-2 Infection Events	R-HSA-9772573	7.529572e-01	0.123
Metabolism of proteins	R-HSA-392499	7.575413e-01	0.121
Uptake and actions of bacterial toxins	R-HSA-5339562	7.616817e-01	0.118
Lagging Strand Synthesis	R-HSA-69186	7.621598e-01	0.118
ERK/MAPK targets	R-HSA-198753	7.621598e-01	0.118
Signalling to RAS	R-HSA-167044	7.621598e-01	0.118
Zygotic genome activation (ZGA)	R-HSA-9819196	7.621598e-01	0.118
Intra-Golgi traffic	R-HSA-6811438	7.624112e-01	0.118
SLC-mediated transport of neurotransmitters	R-HSA-442660	7.624112e-01	0.118
Infectious disease	R-HSA-5663205	7.631652e-01	0.117
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	7.670258e-01	0.115
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	7.670258e-01	0.115
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	7.738273e-01	0.111
DAG1 core M3 glycosylations	R-HSA-8932505	7.738273e-01	0.111
vRNA Synthesis	R-HSA-192814	7.738273e-01	0.111
Chylomicron assembly	R-HSA-8963888	7.738273e-01	0.111
RHOBTB3 ATPase cycle	R-HSA-9706019	7.738273e-01	0.111
CD163 mediating an anti-inflammatory response	R-HSA-9662834	7.738273e-01	0.111
Interleukin-2 signaling	R-HSA-9020558	7.738273e-01	0.111
Dissolution of Fibrin Clot	R-HSA-75205	7.738273e-01	0.111
IGF1R signaling cascade	R-HSA-2428924	7.742733e-01	0.111
Insulin receptor signalling cascade	R-HSA-74751	7.742733e-01	0.111
Cleavage of the damaged pyrimidine	R-HSA-110329	7.758328e-01	0.110
Depyrimidination	R-HSA-73928	7.758328e-01	0.110
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	7.759408e-01	0.110
Signaling by NTRK3 (TRKC)	R-HSA-9034015	7.800957e-01	0.108
Serine metabolism	R-HSA-977347	7.800957e-01	0.108
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	7.800957e-01	0.108
Ribavirin ADME	R-HSA-9755088	7.800957e-01	0.108
G-protein beta:gamma signalling	R-HSA-397795	7.819242e-01	0.107
Cardiogenesis	R-HSA-9733709	7.819242e-01	0.107
Assembly of the ORC complex at the origin of replication	R-HSA-68616	7.819242e-01	0.107
RSV-host interactions	R-HSA-9833110	7.846875e-01	0.105
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	7.851451e-01	0.105
Toll-like Receptor Cascades	R-HSA-168898	7.869531e-01	0.104
Neddylation	R-HSA-8951664	7.886487e-01	0.103
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	7.960266e-01	0.099
Signaling by GSK3beta mutants	R-HSA-5339716	7.966204e-01	0.099
Proton-coupled monocarboxylate transport	R-HSA-433692	7.966204e-01	0.099
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	7.966204e-01	0.099
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	7.966204e-01	0.099
Cytochrome c-mediated apoptotic response	R-HSA-111461	7.966204e-01	0.099
PI-3K cascade:FGFR1	R-HSA-5654689	7.968337e-01	0.099
Regulation of IFNA/IFNB signaling	R-HSA-912694	7.968337e-01	0.099
Notch-HLH transcription pathway	R-HSA-350054	7.968337e-01	0.099
LDL clearance	R-HSA-8964038	7.968337e-01	0.099
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	7.968337e-01	0.099
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	7.968337e-01	0.099
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	7.968337e-01	0.099
DAP12 interactions	R-HSA-2172127	8.008711e-01	0.096
Disease	R-HSA-1643685	8.013622e-01	0.096
Integrin cell surface interactions	R-HSA-216083	8.052846e-01	0.094
ABC transporters in lipid homeostasis	R-HSA-1369062	8.124328e-01	0.090
Stimuli-sensing channels	R-HSA-2672351	8.169975e-01	0.088
MET activates RAS signaling	R-HSA-8851805	8.171178e-01	0.088
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	8.171178e-01	0.088
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	8.171178e-01	0.088
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	8.171178e-01	0.088
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	8.171178e-01	0.088
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	8.171178e-01	0.088
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	8.171178e-01	0.088
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	8.171178e-01	0.088
RUNX3 regulates NOTCH signaling	R-HSA-8941856	8.171178e-01	0.088
GRB2 events in EGFR signaling	R-HSA-179812	8.171178e-01	0.088
Serotonin clearance from the synaptic cleft	R-HSA-380615	8.171178e-01	0.088
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	8.171178e-01	0.088
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	8.171178e-01	0.088
Trafficking and processing of endosomal TLR	R-HSA-1679131	8.171178e-01	0.088
Regulation of IFNG signaling	R-HSA-877312	8.171178e-01	0.088
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	8.171178e-01	0.088
Interleukin-35 Signalling	R-HSA-8984722	8.171178e-01	0.088
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	8.171178e-01	0.088
Transferrin endocytosis and recycling	R-HSA-917977	8.219462e-01	0.085
FOXO-mediated transcription	R-HSA-9614085	8.233635e-01	0.084
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	8.269527e-01	0.083
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	8.269527e-01	0.083
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	8.269527e-01	0.083
Early SARS-CoV-2 Infection Events	R-HSA-9772572	8.279830e-01	0.082
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	8.315883e-01	0.080
GPVI-mediated activation cascade	R-HSA-114604	8.338177e-01	0.079
FGFR2 mutant receptor activation	R-HSA-1839126	8.338177e-01	0.079
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	8.344811e-01	0.079
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	8.355504e-01	0.078
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	8.355504e-01	0.078
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	8.355504e-01	0.078
Platelet Adhesion to exposed collagen	R-HSA-75892	8.355504e-01	0.078
Maturation of nucleoprotein	R-HSA-9683610	8.355504e-01	0.078
Interleukin-6 signaling	R-HSA-1059683	8.355504e-01	0.078
Extra-nuclear estrogen signaling	R-HSA-9009391	8.383143e-01	0.077
PI-3K cascade:FGFR2	R-HSA-5654695	8.404523e-01	0.075
Polymerase switching on the C-strand of the telomere	R-HSA-174411	8.404523e-01	0.075
Glycogen breakdown (glycogenolysis)	R-HSA-70221	8.404523e-01	0.075
Acyl chain remodelling of PS	R-HSA-1482801	8.404523e-01	0.075
SIRT1 negatively regulates rRNA expression	R-HSA-427359	8.450011e-01	0.073
Cleavage of the damaged purine	R-HSA-110331	8.450011e-01	0.073
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	8.459914e-01	0.073
Removal of the Flap Intermediate	R-HSA-69166	8.521262e-01	0.069
Retrograde neurotrophin signalling	R-HSA-177504	8.521262e-01	0.069
cGMP effects	R-HSA-418457	8.521262e-01	0.069
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	8.521262e-01	0.069
Hydrolysis of LPC	R-HSA-1483115	8.521262e-01	0.069
Malate-aspartate shuttle	R-HSA-9856872	8.521262e-01	0.069
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.521262e-01	0.069
Acyl chain remodeling of CL	R-HSA-1482798	8.521262e-01	0.069
Zinc transporters	R-HSA-435354	8.521262e-01	0.069
Neuronal System	R-HSA-112316	8.521297e-01	0.069
TRP channels	R-HSA-3295583	8.529897e-01	0.069
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	8.529897e-01	0.069
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	8.529897e-01	0.069
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	8.529897e-01	0.069
Depurination	R-HSA-73927	8.555252e-01	0.068
Processive synthesis on the C-strand of the telomere	R-HSA-174414	8.646218e-01	0.063
Signaling by FGFR3 in disease	R-HSA-5655332	8.646218e-01	0.063
Maturation of hRSV A proteins	R-HSA-9828806	8.646218e-01	0.063
Erythropoietin activates RAS	R-HSA-9027284	8.670320e-01	0.062
Beta-catenin phosphorylation cascade	R-HSA-196299	8.670320e-01	0.062
SHC1 events in EGFR signaling	R-HSA-180336	8.670320e-01	0.062
G beta:gamma signalling through BTK	R-HSA-8964315	8.670320e-01	0.062
Processive synthesis on the lagging strand	R-HSA-69183	8.670320e-01	0.062
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	8.670320e-01	0.062
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	8.670320e-01	0.062
Lysosphingolipid and LPA receptors	R-HSA-419408	8.670320e-01	0.062
DNA Damage Reversal	R-HSA-73942	8.670320e-01	0.062
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	8.684547e-01	0.061
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	8.710420e-01	0.060
Activation of kainate receptors upon glutamate binding	R-HSA-451326	8.754036e-01	0.058
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	8.754036e-01	0.058
Pyroptosis	R-HSA-5620971	8.754036e-01	0.058
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	8.804362e-01	0.055
Defective GALNT12 causes CRCS1	R-HSA-5083636	8.804362e-01	0.055
Defective GALNT3 causes HFTC	R-HSA-5083625	8.804362e-01	0.055
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	8.804362e-01	0.055
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	8.804362e-01	0.055
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	8.804362e-01	0.055
Attachment and Entry	R-HSA-9678110	8.804362e-01	0.055
Signaling by Erythropoietin	R-HSA-9006335	8.853882e-01	0.053
Downstream signaling of activated FGFR3	R-HSA-5654708	8.853882e-01	0.053
Amino acids regulate mTORC1	R-HSA-9639288	8.868003e-01	0.052
Mitochondrial biogenesis	R-HSA-1592230	8.869044e-01	0.052
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	8.916017e-01	0.050
Scavenging by Class A Receptors	R-HSA-3000480	8.916017e-01	0.050
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	8.924898e-01	0.049
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	8.924898e-01	0.049
TRAF3-dependent IRF activation pathway	R-HSA-918233	8.924898e-01	0.049
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	8.924898e-01	0.049
tRNA modification in the mitochondrion	R-HSA-6787450	8.924898e-01	0.049
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	8.924898e-01	0.049
Base-Excision Repair, AP Site Formation	R-HSA-73929	8.939938e-01	0.049
Downstream signaling of activated FGFR4	R-HSA-5654716	8.946269e-01	0.048
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	8.946269e-01	0.048
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	8.946269e-01	0.048
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	8.983830e-01	0.047
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.031684e-01	0.044
Molecules associated with elastic fibres	R-HSA-2129379	9.031684e-01	0.044
Downstream signal transduction	R-HSA-186763	9.031684e-01	0.044
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	9.033289e-01	0.044
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	9.033289e-01	0.044
Elevation of cytosolic Ca2+ levels	R-HSA-139853	9.033289e-01	0.044
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	9.033289e-01	0.044
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	9.033289e-01	0.044
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.071845e-01	0.042
Adipogenesis	R-HSA-9843745	9.089557e-01	0.041
PI Metabolism	R-HSA-1483255	9.109407e-01	0.041
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.110233e-01	0.040
Signaling by WNT in cancer	R-HSA-4791275	9.110594e-01	0.040
PKA activation	R-HSA-163615	9.130758e-01	0.039
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	9.130758e-01	0.039
PKA activation in glucagon signalling	R-HSA-164378	9.130758e-01	0.039
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	9.130758e-01	0.039
FOXO-mediated transcription of cell death genes	R-HSA-9614657	9.130758e-01	0.039
Tie2 Signaling	R-HSA-210993	9.130758e-01	0.039
Amine ligand-binding receptors	R-HSA-375280	9.131212e-01	0.039
Synthesis of PA	R-HSA-1483166	9.132171e-01	0.039
Cytoprotection by HMOX1	R-HSA-9707564	9.193965e-01	0.036
E2F mediated regulation of DNA replication	R-HSA-113510	9.218404e-01	0.035
O2/CO2 exchange in erythrocytes	R-HSA-1480926	9.218404e-01	0.035
Diseases of hemostasis	R-HSA-9671793	9.218404e-01	0.035
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	9.218404e-01	0.035
Amino acid transport across the plasma membrane	R-HSA-352230	9.242425e-01	0.034
Acyl chain remodelling of PC	R-HSA-1482788	9.250648e-01	0.034
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.252273e-01	0.034
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.252273e-01	0.034
Metabolism of polyamines	R-HSA-351202	9.292685e-01	0.032
Signaling by NODAL	R-HSA-1181150	9.297218e-01	0.032
Acyl chain remodelling of PI	R-HSA-1482922	9.297218e-01	0.032
Diseases of carbohydrate metabolism	R-HSA-5663084	9.302841e-01	0.031
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.312609e-01	0.031
Signal amplification	R-HSA-392518	9.312609e-01	0.031
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	9.325628e-01	0.030
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	9.354942e-01	0.029
Matriglycan biosynthesis on DAG1	R-HSA-9939291	9.368089e-01	0.028
G-protein activation	R-HSA-202040	9.368089e-01	0.028
PKA-mediated phosphorylation of CREB	R-HSA-111931	9.368089e-01	0.028
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.368089e-01	0.028
Vitamin C (ascorbate) metabolism	R-HSA-196836	9.368089e-01	0.028
Acyl chain remodelling of PG	R-HSA-1482925	9.368089e-01	0.028
Downstream signaling of activated FGFR2	R-HSA-5654696	9.369698e-01	0.028
Downstream signaling of activated FGFR1	R-HSA-5654687	9.369698e-01	0.028
Acyl chain remodelling of PE	R-HSA-1482839	9.369698e-01	0.028
Signaling by PDGF	R-HSA-186797	9.384266e-01	0.028
RUNX2 regulates bone development	R-HSA-8941326	9.422269e-01	0.026
FRS-mediated FGFR3 signaling	R-HSA-5654706	9.431816e-01	0.025
Attachment and Entry	R-HSA-9694614	9.431816e-01	0.025
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.461287e-01	0.024
TRAF6 mediated IRF7 activation	R-HSA-933541	9.470651e-01	0.024
Cardiac conduction	R-HSA-5576891	9.481830e-01	0.023
FRS-mediated FGFR4 signaling	R-HSA-5654712	9.489121e-01	0.023
Cellular hexose transport	R-HSA-189200	9.489121e-01	0.023
RAF-independent MAPK1/3 activation	R-HSA-112409	9.489121e-01	0.023
Elastic fibre formation	R-HSA-1566948	9.515154e-01	0.022
Termination of O-glycan biosynthesis	R-HSA-977068	9.540648e-01	0.020
Interleukin receptor SHC signaling	R-HSA-912526	9.540648e-01	0.020
Interleukin-20 family signaling	R-HSA-8854691	9.540648e-01	0.020
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.556069e-01	0.020
FCERI mediated NF-kB activation	R-HSA-2871837	9.559085e-01	0.020
SLC-mediated transport of amino acids	R-HSA-9958863	9.567904e-01	0.019
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	9.586982e-01	0.018
Plasma lipoprotein assembly	R-HSA-8963898	9.586982e-01	0.018
Mitochondrial RNA degradation	R-HSA-9836573	9.586982e-01	0.018
Complex III assembly	R-HSA-9865881	9.586982e-01	0.018
Interleukin-6 family signaling	R-HSA-6783589	9.586982e-01	0.018
Interleukin-2 family signaling	R-HSA-451927	9.593666e-01	0.018
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.596563e-01	0.018
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	9.603200e-01	0.018
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	9.603200e-01	0.018
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	9.603200e-01	0.018
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	9.605429e-01	0.017
Paracetamol ADME	R-HSA-9753281	9.627651e-01	0.016
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.628198e-01	0.016
Maturation of spike protein	R-HSA-9694548	9.628198e-01	0.016
FRS-mediated FGFR1 signaling	R-HSA-5654693	9.628644e-01	0.016
Hyaluronan degradation	R-HSA-2160916	9.628644e-01	0.016
Formation of the nephric duct	R-HSA-9830364	9.628644e-01	0.016
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	9.628644e-01	0.016
Laminin interactions	R-HSA-3000157	9.628644e-01	0.016
Interferon alpha/beta signaling	R-HSA-909733	9.631084e-01	0.016
Mitochondrial protein degradation	R-HSA-9837999	9.637388e-01	0.016
COPII-mediated vesicle transport	R-HSA-204005	9.652296e-01	0.015
Urea cycle	R-HSA-70635	9.666106e-01	0.015
Sphingolipid catabolism	R-HSA-9845614	9.666106e-01	0.015
Abacavir ADME	R-HSA-2161522	9.666106e-01	0.015
Rab regulation of trafficking	R-HSA-9007101	9.671626e-01	0.015
Cytosolic tRNA aminoacylation	R-HSA-379716	9.688994e-01	0.014
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.688994e-01	0.014
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	9.688994e-01	0.014
Signaling by BMP	R-HSA-201451	9.699791e-01	0.013
TBC/RABGAPs	R-HSA-8854214	9.715680e-01	0.013
FRS-mediated FGFR2 signaling	R-HSA-5654700	9.730079e-01	0.012
Prednisone ADME	R-HSA-9757110	9.730079e-01	0.012
Regulation of insulin secretion	R-HSA-422356	9.737708e-01	0.012
RAB geranylgeranylation	R-HSA-8873719	9.750598e-01	0.011
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.757313e-01	0.011
Neurotransmitter clearance	R-HSA-112311	9.781801e-01	0.010
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.781801e-01	0.010
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.783128e-01	0.010
Neurotransmitter release cycle	R-HSA-112310	9.792783e-01	0.009
Interferon gamma signaling	R-HSA-877300	9.800388e-01	0.009
GPER1 signaling	R-HSA-9634597	9.819182e-01	0.008
Metal ion SLC transporters	R-HSA-425410	9.819182e-01	0.008
DAG1 glycosylations	R-HSA-8931838	9.823616e-01	0.008
Recycling of bile acids and salts	R-HSA-159418	9.841417e-01	0.007
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.847455e-01	0.007
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.851170e-01	0.007
Leishmania phagocytosis	R-HSA-9664417	9.851170e-01	0.007
Parasite infection	R-HSA-9664407	9.851170e-01	0.007
Peptide hormone metabolism	R-HSA-2980736	9.851986e-01	0.006
Platelet homeostasis	R-HSA-418346	9.856528e-01	0.006
Glucagon signaling in metabolic regulation	R-HSA-163359	9.857422e-01	0.006
Miscellaneous transport and binding events	R-HSA-5223345	9.857422e-01	0.006
Effects of PIP2 hydrolysis	R-HSA-114508	9.857422e-01	0.006
Heme degradation	R-HSA-189483	9.857422e-01	0.006
Kidney development	R-HSA-9830369	9.859600e-01	0.006
The phototransduction cascade	R-HSA-2514856	9.862588e-01	0.006
eNOS activation	R-HSA-203615	9.871813e-01	0.006
Hyaluronan metabolism	R-HSA-2142845	9.871813e-01	0.006
Nucleotide biosynthesis	R-HSA-8956320	9.885696e-01	0.005
Triglyceride catabolism	R-HSA-163560	9.896386e-01	0.005
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.899523e-01	0.004
ECM proteoglycans	R-HSA-3000178	9.899523e-01	0.004
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.904177e-01	0.004
G alpha (z) signalling events	R-HSA-418597	9.904997e-01	0.004
Formation of the cornified envelope	R-HSA-6809371	9.906798e-01	0.004
Voltage gated Potassium channels	R-HSA-1296072	9.906845e-01	0.004
SLC-mediated transport of organic cations	R-HSA-549127	9.906845e-01	0.004
Metabolism of folate and pterines	R-HSA-196757	9.906845e-01	0.004
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.907646e-01	0.004
Aspirin ADME	R-HSA-9749641	9.915132e-01	0.004
tRNA processing in the mitochondrion	R-HSA-6785470	9.916250e-01	0.004
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.916250e-01	0.004
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.918015e-01	0.004
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.932308e-01	0.003
rRNA processing in the mitochondrion	R-HSA-8868766	9.932308e-01	0.003
Tryptophan catabolism	R-HSA-71240	9.932308e-01	0.003
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.932308e-01	0.003
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.934524e-01	0.003
tRNA Aminoacylation	R-HSA-379724	9.940370e-01	0.003
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	9.945288e-01	0.002
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.956850e-01	0.002
Surfactant metabolism	R-HSA-5683826	9.960247e-01	0.002
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.960247e-01	0.002
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.964262e-01	0.002
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.964262e-01	0.002
Integration of energy metabolism	R-HSA-163685	9.966821e-01	0.001
Synthesis of PC	R-HSA-1483191	9.971117e-01	0.001
Plasma lipoprotein remodeling	R-HSA-8963899	9.974035e-01	0.001
Extracellular matrix organization	R-HSA-1474244	9.974631e-01	0.001
Chemokine receptors bind chemokines	R-HSA-380108	9.976658e-01	0.001
Role of phospholipids in phagocytosis	R-HSA-2029485	9.977980e-01	0.001
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.979017e-01	0.001
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.980802e-01	0.001
Complex IV assembly	R-HSA-9864848	9.981137e-01	0.001
Cytosolic sulfonation of small molecules	R-HSA-156584	9.981137e-01	0.001
ROS and RNS production in phagocytes	R-HSA-1222556	9.984161e-01	0.001
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.987480e-01	0.001
Collagen formation	R-HSA-1474290	9.988548e-01	0.000
Innate Immune System	R-HSA-168249	9.988659e-01	0.000
SLC-mediated transport of organic anions	R-HSA-9955298	9.989208e-01	0.000
Interleukin-10 signaling	R-HSA-6783783	9.989208e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.989378e-01	0.000
Dectin-2 family	R-HSA-5621480	9.990046e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.990236e-01	0.000
Triglyceride metabolism	R-HSA-8979227	9.991957e-01	0.000
PPARA activates gene expression	R-HSA-1989781	9.992239e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.993312e-01	0.000
Aquaporin-mediated transport	R-HSA-445717	9.993501e-01	0.000
Phospholipid metabolism	R-HSA-1483257	9.994112e-01	0.000
Complex I biogenesis	R-HSA-6799198	9.994749e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.995192e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.995341e-01	0.000
Nicotinate metabolism	R-HSA-196807	9.996572e-01	0.000
O-linked glycosylation of mucins	R-HSA-913709	9.996918e-01	0.000
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.996918e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.996936e-01	0.000
Parasitic Infection Pathways	R-HSA-9824443	9.997250e-01	0.000
Leishmania infection	R-HSA-9658195	9.997250e-01	0.000
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.997510e-01	0.000
Metabolism of cofactors	R-HSA-8978934	9.997762e-01	0.000
Metabolism of porphyrins	R-HSA-189445	9.997762e-01	0.000
G alpha (s) signalling events	R-HSA-418555	9.997867e-01	0.000
FCGR activation	R-HSA-2029481	9.997927e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.998113e-01	0.000
FCERI mediated MAPK activation	R-HSA-2871796	9.998130e-01	0.000
Citric acid cycle (TCA cycle)	R-HSA-71403	9.998539e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.998744e-01	0.000
Transport of small molecules	R-HSA-382551	9.998841e-01	0.000
Drug ADME	R-HSA-9748784	9.999424e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.999441e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.999614e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999803e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999810e-01	0.000
G alpha (q) signalling events	R-HSA-416476	9.999820e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999830e-01	0.000
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.999841e-01	0.000
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.999861e-01	0.000
Keratinization	R-HSA-6805567	9.999879e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.999887e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.999887e-01	0.000
Potassium Channels	R-HSA-1296071	9.999887e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.999897e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.999909e-01	0.000
Bacterial Infection Pathways	R-HSA-9824439	9.999921e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999950e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999975e-01	0.000
Arachidonate metabolism	R-HSA-2142753	9.999975e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999979e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.999979e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999981e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999987e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999990e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999996e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999998e-01	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	9.999999e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.999999e-01	0.000
Metabolism of steroids	R-HSA-8957322	1.000000e+00	0.000
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000
GPCR downstream signalling	R-HSA-388396	1.000000e+00	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	1.000000e+00	0.000
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000