NDR1

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A6NMY6 S164 Sugiyama ANXA2P2 ANX2L2 ANX2P2 LPC2B NRVyKEMYKtDLEKDIIsDtsGDFRKLMVALAKGRRAEDGS
O00488 S98 Sugiyama ZNF593 ZT86 THFRSKDHKKRLKQLsVEPysQEEAERAAGMGSYVPPRRLA
O14980 S1055 SIGNOR|PSP|Sugiyama XPO1 CRM1 LEEREIALRQADEEKHKRQMsVPGIFNPHEIPEEMCD____
O60814 S37 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
O60814 S39 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04083 S173 Sugiyama ANXA1 ANX1 LPC1 NRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRsEDFG
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04792 S78 Sugiyama HSPB1 HSP27 HSP28 LPPAAIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVs
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P06733 S27 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P06899 S37 Sugiyama H2BC11 H2BFR HIST1H2BJ KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISS
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07355 S164 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D NRVyKEMYKtDLEKDIIsDtsGDFRKLMVALAKGRRAEDGs
P07814 S335 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 PIEKNLQMWEEMKKGsQFGQsCCLRAKIDMSSNNGCMRDPt
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900 S53 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P07900 Y284 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DEEEEKKDGDKKKKKKIKEKyIDQEELNKtKPIWtRNPDDI
P08238 Y276 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DEEDDsGKDKKKKTKKIKEKyIDQEELNKtKPIWtRNPDDI
P11142 T163 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14618 T50 Sugiyama PKM OIP3 PK2 PK3 PKM2 MCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMIKsGMN
P14625 S514 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK
P18621 T79 Sugiyama RPL17 PFRRYNGGVGRCAQAKQWGWtQGRWPKKSAEFLLHMLKNAE
P22059 S379 Sugiyama OSBP OSBP1 FFDAPEIITMPENLGHKRtGsNIsGAssDIsLDEQyKHQLE
P23526 S183 Sugiyama AHCY SAHH NLyKMMANGILKVPAINVNDsVtKsKFDNLyGCRESLIDGI
P23527 S37 Sugiyama H2BC17 H2BFH H2BFN HIST1H2BO KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISS
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P27348 S45 Sugiyama YWHAQ CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P29692 S65 Sugiyama EEF1D EF1D VILRDIARARENIQKsLAGssGPGAssGtsGDHGELVVRIA
P29692 S74 Sugiyama EEF1D EF1D RENIQKsLAGssGPGAssGtsGDHGELVVRIAsLEVENQsL
P30086 S52 Sugiyama PEBP1 PBP PEBP AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P31946 S47 Sugiyama YWHAB AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947 S45 Sugiyama SFN HME1 FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P31949 T33 Sugiyama S100A11 MLN70 S100C CIESLIAVFQKYAGKDGyNytLsKtEFLsFMNTELAAFTKN
P33316 S120 Sugiyama DUT PsKRARPAEVGGMQLRFARLsEHAtAPTRGsARAAGYDLYS
P33778 S37 Sugiyama H2BC3 H2BFF HIST1H2BB KAITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISS
P34932 S76 Sugiyama HSPA4 APG2 HSPH2 VISNAKNTVQGFKRFHGRAFsDPFVEAEKSNLAYDIVQLPT
P35269 T41 Sugiyama GTF2F1 RAP74 NTTKKyNIMAFNAADKVNFAtWNQARLERDLSNKKIyQEEE
P36578 T84 Sugiyama RPL4 RPL1 AEsWGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAP
P37108 Y27 Sugiyama SRP14 EQFLtELTRLFQKCRTSGsVyItLKKYDGRTKPIPKKGtVE
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38936 S146 SIGNOR CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1 QAEGsPGGPGDSQGRKRRQtsMTDFYHsKRRLIFSKRKP__
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46783 S146 Sugiyama RPS10 TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P46937 S109 SIGNOR|EPSD|PSP|Sugiyama YAP1 YAP65 RKLPDsFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssP
P46937 S127 SIGNOR|EPSD|PSP YAP1 YAP65 QAstDAGtAGALtPQHVRAHssPAsLQLGAVsPGtLtPtGV
P46937 S164 EPSD|PSP YAP1 YAP65 PtGVVsGPAAtPTAQHLRQssFEIPDDVPLPAGWEMAKTSS
P46937 S61 EPSD|PSP YAP1 YAP65 tQAAPQAPPAGHQIVHVRGDsEtDLEALFNAVMNPKtANVP
P47712 S727 Sugiyama PLA2G4A CPLA2 PLA2G4 VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P49321 S659 Sugiyama NASP IEELKELLPEIREKIEDAKEsQRsGNVAELALKATLVEsst
P49321 S662 Sugiyama NASP LKELLPEIREKIEDAKEsQRsGNVAELALKATLVEsstsGF
P50990 S23 Sugiyama CCT8 C21orf112 CCTQ KIAA0002 LHVPKAPGFAQMLKEGAKHFsGLEEAVyRNIQACKELAQTT
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51116 T598 Sugiyama FXR2 FMR1L2 DESRPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRA
P51532 S1382 Sugiyama SMARCA4 BAF190A BRG1 SNF2B SNF2L4 EEEKMFGRGSRHRKEVDYsDsLTEKQWLKAIEEGtLEEIEE
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53396 S459 Sugiyama ACLY LNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMPQDsV
P57053 S37 Sugiyama H2BC12L H2BFS H2BS1 KAVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIss
P57053 S39 Sugiyama H2BC12L H2BFS H2BS1 VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P58876 S37 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
P58876 S39 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61221 Y594 Sugiyama ABCE1 RLI RNASEL1 RNASELI RNS4I OK/SW-cl.40 RPRINKLNsIKDVEQKKsGNyFFLDD_______________
P61247 S236 Sugiyama RPS3A FTE1 MFTL KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61247 S238 Sugiyama RPS3A FTE1 MFTL LKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGyEP
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61978 T70 Sugiyama HNRNPK HNRPK QSKNAGAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsI
P61981 S46 Sugiyama YWHAG AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S46 Sugiyama YWHAE SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62263 S137 Sugiyama RPS14 PRO2640 RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62424 T84 Sugiyama RPL7A SURF-3 SURF3 QRQRAILyKRLKVPPAINQFtQALDRQTAtQLLKLAHKYRP
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62807 S37 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI KAVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIss
P62807 S39 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA
P62899 S15 Sugiyama RPL31 ______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P63104 S45 Sugiyama YWHAZ CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63173 T14 Sugiyama RPL38 _______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P67809 S209 Sugiyama YBX1 NSEP1 YB1 RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P78345 S253 Sugiyama RPP38 DtsFEDLsKPKRKLADGRQAsVtLQPLKIKKLIPNPNKIRK
Q00839 Y260 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 GDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVEEED
Q02241 S716 EPSD|PSP KIF23 KNSL5 MKLP1 AQISNGQQLMSQPQLHRRsNsCssISVASCISEWEQKIPTy
Q02241 S814 EPSD|PSP KIF23 KNSL5 MKLP1 LLFQPDQNAPPIRLRHRRsRsAGDRWVDHKPASNMQTETVM
Q04917 S46 Sugiyama YWHAH YWHA1 AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q07020 T136 Sugiyama RPL18 AGGKILtFDQLALDsPKGCGtVLLsGPRKGREVYRHFGKAP
Q07020 T85 Sugiyama RPL18 RMIRKMKLPGRENKtAVVVGtItDDVRVQEVPKLKVCALRV
Q13247 S297 Sugiyama SRSF6 SFRS6 SRP55 RSRSPKENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsP
Q13442 S19 Sugiyama PDAP1 HASPP28 __MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEEE
Q13561 Y81 Sugiyama DCTN2 DCTN50 RVGTKGLDFsDRIGKTKRtGyEsGEyEMLGEGLGVKETPQQ
Q14568 S53 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14568 Y283 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 sDEEEEKKDGDKKKKKTKEKyIDQEELNKTKPIWTRNPDDI
Q14847 S61 Sugiyama LASP1 MLN50 MKNYKGYEKKPYCNAHyPKQsFtMVADtPENLRLKQQSELQ
Q14978 S686 Sugiyama NOLC1 KIAA0035 NS5ATP13 KGKSFRHEKTKKKRGsYRGGsIsVQVNsIKFDsE_______
Q15208 S281 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP STK38 NDR1 NMNsKRKAEtWKRNRRQLAFstVGtPDYIAPEVFMQTGYNK
Q15208 S32 Sugiyama STK38 NDR1 MSNHTKERVTMTKVTLENFysNLIAQHEEREMRQKKLEKVM
Q15208 S398 Sugiyama STK38 NDR1 SNSFFEGVDWEHIRERPAAIsIEIKSIDDtSNFDEFPESDI
Q15208 S459 Sugiyama STK38 NDR1 VFINytYKRFEGLtARGAIPsYMKAAK______________
Q15208 T444 SIGNOR|iPTMNet|EPSD|PSP|Sugiyama STK38 NDR1 ATSNHPETDYKNKDWVFINytYKRFEGLtARGAIPsYMKAA
Q15208 T452 Sugiyama STK38 NDR1 DYKNKDWVFINytYKRFEGLtARGAIPsYMKAAK_______
Q15208 T74 SIGNOR|iPTMNet|EPSD|Sugiyama STK38 NDR1 EEGLKDEEKRLRRSAHARKEtEFLRLKRTRLGLEDFEsLKV
Q15208 Y443 Sugiyama STK38 NDR1 VATSNHPETDYKNKDWVFINytYKRFEGLtARGAIPsYMKA
Q15293 Y115 Sugiyama RCN1 RCN GDGFVttEELKtWIKRVQKRyIFDNVAKVWKDYDRDKDDKI
Q16658 T239 Sugiyama FSCN1 FAN1 HSN SNL GKVAFRDCEGRyLAPsGPsGtLKAGKATKVGKDELFALEQs
Q16778 S37 Sugiyama H2BC21 H2BFQ HIST2H2BE KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIss
Q2M2I8 S637 SIGNOR AAK1 KIAA1048 GsLtPPssPKTQRAGHRRILsDVtHsAVFGVPAsKstQLLQ
Q58FF8 Y198 Sugiyama HSP90AB2P HSP90BB DEEDDsGKDKKKKTKKIKEKyIDQEELNKTKPIWTRNTEDI
Q5QNW6 S37 Sugiyama H2BC18 HIST2H2BF KAVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q5QNW6 S39 Sugiyama H2BC18 HIST2H2BF VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q5T5C0 S692 Sugiyama STXBP5 LLGL3 YGSNDPYRREPRSPRKsRQPsGAGLCDIsEGtVVPEDRCKS
Q6DN03 S37 Sugiyama H2BC20P HIST2H2BC KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWC
Q6DRA6 S37 Sugiyama H2BC19P HIST2H2BD KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWC
Q6P6C2 S361 Sugiyama ALKBH5 ABH5 OFOXD1 EMDKEENRRSVLLPTHRRRGsFssENYWRKsyEssEDCsEA
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q7Z417 S655 Sugiyama NUFIP2 KIAA1321 PIG1 LGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsIWNL
Q7Z4V5 S454 Sugiyama HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 VRPEEKQQAKPVKVERTRKRsEGFsMDRKVEKKKEPSVEEK
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q8N257 S37 Sugiyama H2BC26 H2BU1 HIST3H2BB KAVTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIss
Q93079 S37 Sugiyama H2BC9 H2BFJ HIST1H2BH KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q93079 S39 Sugiyama H2BC9 H2BFJ HIST1H2BH VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q96QF0 S288 SIGNOR|EPSD|PSP RAB3IP RABIN8 tQEPLPGGKTPFKKGHTRNKstssAMsGsHQDLSVIQPIVK
Q96RD6 S514 SIGNOR PANX2 GPAPAPAPPPAPDKKHARHFsLDVHPYILGTKKAKAEAVPA
Q99877 S37 Sugiyama H2BC15 H2BFD HIST1H2BN KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99877 S39 Sugiyama H2BC15 H2BFD HIST1H2BN VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99879 S37 Sugiyama H2BC14 H2BFE HIST1H2BM KAINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99879 S39 Sugiyama H2BC14 H2BFE HIST1H2BM INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99880 S37 Sugiyama H2BC13 H2BFC HIST1H2BL KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99880 S39 Sugiyama H2BC13 H2BFC HIST1H2BL VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q9BTU6 S462 Sugiyama PI4K2A HLVQMPPVIVETARSHQRsssEsyTQsFQSRKPFFSWW___
Q9BXF6 S307 SIGNOR RAB11FIP5 GAF1 KIAA0857 RIP11 TEGGRDsAQsPKLFTHKRtYsDEANQMRVAPPRALLDLQGH
Q9GZL7 S206 Sugiyama WDR12 RGHAGSVDSIAVDGSGTKFCsGSWDKMLKIWStVPtDEEDE
Q9H1K0 S548 Sugiyama RBSN ZFYVE20 RELEREREQFRVASLHTRTRsLDFREIGPFQLEPSREPRTH
Q9NQ39 S157 Sugiyama RPS10P5 RPS10L TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9NTI5 S1257 Sugiyama PDS5B APRIN AS3 KIAA0979 LVQEQKPKGSQRSRKRGHtAsEsDEQQWPEEKRLKEDILEN
Q9UBF8 S277 SIGNOR PI4KB PIK4CB LsPAPDtGLsPsKRTHQRsKsDAtAsISLSSNLKRTAsNPK
Q9UGV2 S331 Sugiyama NDRG3 QGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQ
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UKX7 S52 Sugiyama NUP50 NPAP60L PRO1146 EEVLKNRAIKKAKRRNVGFEsDtGGAFKGFKGLVVPSGGGR
Q9UPQ0 S201 Sugiyama LIMCH1 KIAA1102 DCWDsERsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVV
Q9UQ35 S2692 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9UQE7 S961 Sugiyama SMC3 BAM BMH CSPG6 SMC3L1 KKIRELGSLPQEAFEKYQtLsLKQLFRKLEQCNTELKKYSH
Q9UQE7 T959 Sugiyama SMC3 BAM BMH CSPG6 SMC3L1 CMKKIRELGSLPQEAFEKYQtLsLKQLFRKLEQCNTELKKY
Q9Y2H1 T75 Sugiyama STK38L KIAA0965 NDR2 EEGLADEEKKLRRSQHARKEtEFLRLKRTRLGLDDFESLKV
Q9Y5M8 S257 Sugiyama SRPRB PSEC0230 LPLKVEFLECSAKGGRGDVGsADIQDLEKWLAKIA______
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Chromatin modifying enzymes R-HSA-3247509 5.936080e-07 6.227 0 0
Chromatin organization R-HSA-4839726 1.694982e-06 5.771 0 0
PKMTs methylate histone lysines R-HSA-3214841 5.157315e-06 5.288 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.543131e-05 4.812 0 0
Gene expression (Transcription) R-HSA-74160 1.792156e-05 4.747 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 3.536869e-05 4.451 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 3.645184e-05 4.438 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 4.342138e-05 4.362 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 4.459275e-05 4.351 0 0
mRNA Splicing - Major Pathway R-HSA-72163 5.530779e-05 4.257 0 0
RNA Polymerase II Transcription R-HSA-73857 5.693850e-05 4.245 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 7.704724e-05 4.113 0 0
mRNA Splicing R-HSA-72172 8.973879e-05 4.047 0 0
mRNA 3'-end processing R-HSA-72187 1.002622e-04 3.999 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.777902e-04 3.750 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.961270e-04 3.707 0 0
Axon guidance R-HSA-422475 2.084426e-04 3.681 0 0
G alpha (12/13) signalling events R-HSA-416482 2.324438e-04 3.634 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.305170e-04 3.637 0 0
Apoptotic execution phase R-HSA-75153 2.421381e-04 3.616 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.247476e-04 3.488 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 3.727502e-04 3.429 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.822708e-04 3.418 0 0
Nervous system development R-HSA-9675108 4.837472e-04 3.315 0 0
Germ layer formation at gastrulation R-HSA-9754189 5.708942e-04 3.243 0 0
Regulation of TP53 Activity R-HSA-5633007 5.607490e-04 3.251 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.125614e-03 2.949 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.125614e-03 2.949 0 0
Cellular Senescence R-HSA-2559583 1.179661e-03 2.928 0 0
Specification of primordial germ cells R-HSA-9827857 1.198151e-03 2.921 0 0
Cell Cycle R-HSA-1640170 1.364318e-03 2.865 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.780918e-03 2.749 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.809263e-03 2.742 0 0
Generic Transcription Pathway R-HSA-212436 1.769973e-03 2.752 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.214558e-03 2.655 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.412196e-03 2.618 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.821066e-03 2.550 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.829821e-03 2.548 0 0
Signal Transduction R-HSA-162582 2.967688e-03 2.528 1 0
Oncogenic MAPK signaling R-HSA-6802957 3.215896e-03 2.493 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 3.296596e-03 2.482 0 0
HDMs demethylate histones R-HSA-3214842 3.645351e-03 2.438 0 0
NRAGE signals death through JNK R-HSA-193648 3.685537e-03 2.433 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 3.570680e-03 2.447 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.925913e-03 2.406 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 4.034701e-03 2.394 0 0
Signaling by ROBO receptors R-HSA-376176 4.326992e-03 2.364 0 0
PIP3 activates AKT signaling R-HSA-1257604 4.572039e-03 2.340 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 4.598837e-03 2.337 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 4.984630e-03 2.302 0 0
HATs acetylate histones R-HSA-3214847 5.266550e-03 2.278 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 5.402887e-03 2.267 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 5.402887e-03 2.267 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 5.755180e-03 2.240 0 0
Estrogen-dependent gene expression R-HSA-9018519 7.191119e-03 2.143 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 6.810127e-03 2.167 0 0
Rap1 signalling R-HSA-392517 7.318458e-03 2.136 0 0
Metabolism of RNA R-HSA-8953854 7.073876e-03 2.150 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 7.091192e-03 2.149 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 9.156032e-03 2.038 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 9.156032e-03 2.038 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.935068e-03 2.049 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 9.166284e-03 2.038 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 9.421060e-03 2.026 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 9.421060e-03 2.026 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.195000e-02 1.923 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.182193e-02 1.927 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.353646e-02 1.868 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 1.429357e-02 1.845 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.388555e-02 1.857 0 0
Signaling by Hippo R-HSA-2028269 1.474139e-02 1.831 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.547653e-02 1.810 0 0
Cell Cycle Checkpoints R-HSA-69620 1.547654e-02 1.810 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.587017e-02 1.799 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.807530e-02 1.743 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 1.828604e-02 1.738 0 0
Polo-like kinase mediated events R-HSA-156711 1.828604e-02 1.738 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.807530e-02 1.743 0 0
Heme signaling R-HSA-9707616 1.745340e-02 1.758 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.889963e-02 1.724 0 0
Cell Cycle, Mitotic R-HSA-69278 1.894221e-02 1.723 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.907561e-02 1.720 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.907561e-02 1.720 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.032961e-02 1.692 0 0
Semaphorin interactions R-HSA-373755 1.949688e-02 1.710 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.044485e-02 1.689 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.065056e-02 1.685 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.258244e-02 1.646 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.258244e-02 1.646 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.258244e-02 1.646 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.258244e-02 1.646 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.258244e-02 1.646 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.205564e-02 1.656 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.274591e-02 1.643 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.452000e-02 1.610 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.452000e-02 1.610 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.452000e-02 1.610 0 0
Signaling by RAS mutants R-HSA-6802949 2.452000e-02 1.610 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.378393e-02 1.624 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.434233e-02 1.614 0 0
Neurodegenerative Diseases R-HSA-8863678 2.434233e-02 1.614 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.523670e-02 1.598 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.680929e-02 1.572 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.680929e-02 1.572 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 2.732576e-02 1.563 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.795584e-02 1.554 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.779740e-02 1.556 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.854891e-02 1.544 0 0
RET signaling R-HSA-8853659 2.915300e-02 1.535 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 2.925765e-02 1.534 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 2.949732e-02 1.530 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 3.264769e-02 1.486 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 3.080518e-02 1.511 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 3.105690e-02 1.508 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 3.264769e-02 1.486 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.253689e-02 1.488 0 0
MTOR signalling R-HSA-165159 3.228535e-02 1.491 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.304517e-02 1.481 0 0
TRP channels R-HSA-3295583 3.363926e-02 1.473 0 0
Reproduction R-HSA-1474165 3.433863e-02 1.464 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.514053e-02 1.454 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.840356e-02 1.416 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.576762e-02 1.447 0 0
ESR-mediated signaling R-HSA-8939211 3.583369e-02 1.446 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.872819e-02 1.412 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.872819e-02 1.412 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 3.884952e-02 1.411 0 0
Interaction between L1 and Ankyrins R-HSA-445095 3.908620e-02 1.408 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.922414e-02 1.406 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.924727e-02 1.406 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.924727e-02 1.406 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 4.716293e-02 1.326 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 4.806159e-02 1.318 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.476051e-02 1.349 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 4.507082e-02 1.346 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 4.806159e-02 1.318 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 4.771540e-02 1.321 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.554910e-02 1.342 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 4.806159e-02 1.318 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 5.069330e-02 1.295 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 5.095039e-02 1.293 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 5.164974e-02 1.287 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 5.164974e-02 1.287 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 5.167384e-02 1.287 0 0
Kinesins R-HSA-983189 5.406125e-02 1.267 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 6.565605e-02 1.183 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 6.565605e-02 1.183 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 6.435281e-02 1.191 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 6.051957e-02 1.218 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 5.884352e-02 1.230 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 6.639701e-02 1.178 0 0
Specification of the neural plate border R-HSA-9834899 6.080268e-02 1.216 0 0
NGF-stimulated transcription R-HSA-9031628 6.212231e-02 1.207 0 0
DNA Double-Strand Break Repair R-HSA-5693532 6.403742e-02 1.194 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 6.456637e-02 1.190 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 5.487005e-02 1.261 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 6.565605e-02 1.183 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 5.884352e-02 1.230 0 0
Ca-dependent events R-HSA-111996 6.639701e-02 1.178 0 0
Calmodulin induced events R-HSA-111933 6.332535e-02 1.198 0 0
CaM pathway R-HSA-111997 6.332535e-02 1.198 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 6.435281e-02 1.191 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 6.435281e-02 1.191 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 6.051957e-02 1.218 0 0
Interleukin-37 signaling R-HSA-9008059 5.884352e-02 1.230 0 0
Trafficking of AMPA receptors R-HSA-399719 6.661064e-02 1.176 0 0
Regulation of endogenous retroelements R-HSA-9842860 6.733021e-02 1.172 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 6.787835e-02 1.168 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 7.003517e-02 1.155 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 7.073483e-02 1.150 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 7.085663e-02 1.150 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.083134e-01 0.965 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.083134e-01 0.965 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.083134e-01 0.965 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.083134e-01 0.965 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.083134e-01 0.965 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.083134e-01 0.965 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.083134e-01 0.965 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.083134e-01 0.965 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.083134e-01 0.965 0 0
Regulation of TP53 Expression R-HSA-6804754 7.788512e-02 1.109 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 7.788512e-02 1.109 0 0
Potassium transport channels R-HSA-1296067 7.788512e-02 1.109 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.049007e-01 0.688 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.049007e-01 0.688 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.049007e-01 0.688 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.049007e-01 0.688 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.131316e-01 0.946 0 0
Axonal growth stimulation R-HSA-209563 1.131316e-01 0.946 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 8.617867e-02 1.065 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.515630e-01 0.819 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.515630e-01 0.819 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 2.910307e-01 0.536 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 2.910307e-01 0.536 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 2.910307e-01 0.536 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.910307e-01 0.536 0 0
Intestinal infectious diseases R-HSA-8942233 2.910307e-01 0.536 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 2.910307e-01 0.536 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.910307e-01 0.536 0 0
IKBKB deficiency causes SCID R-HSA-5602636 2.910307e-01 0.536 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 2.910307e-01 0.536 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.910307e-01 0.536 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 2.910307e-01 0.536 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.910307e-01 0.536 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.090405e-01 0.962 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 1.920767e-01 0.717 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 1.920767e-01 0.717 0 0
IRS activation R-HSA-74713 1.920767e-01 0.717 0 0
Type I hemidesmosome assembly R-HSA-446107 1.339473e-01 0.873 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 1.339473e-01 0.873 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 1.339473e-01 0.873 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 1.339473e-01 0.873 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 9.604585e-02 1.018 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 9.604585e-02 1.018 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.141690e-01 0.942 0 0
p75NTR regulates axonogenesis R-HSA-193697 1.605919e-01 0.794 0 0
ARMS-mediated activation R-HSA-170984 1.605919e-01 0.794 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.337714e-01 0.631 0 0
Signaling by MAPK mutants R-HSA-9652817 2.337714e-01 0.631 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.678351e-01 0.434 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.678351e-01 0.434 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.678351e-01 0.434 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.678351e-01 0.434 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.678351e-01 0.434 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.678351e-01 0.434 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 3.678351e-01 0.434 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) R-HSA-5619049 3.678351e-01 0.434 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.678351e-01 0.434 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.678351e-01 0.434 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.678351e-01 0.434 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.678351e-01 0.434 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.678351e-01 0.434 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.678351e-01 0.434 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 3.678351e-01 0.434 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 3.678351e-01 0.434 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.678351e-01 0.434 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.678351e-01 0.434 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 9.666507e-02 1.015 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 9.666507e-02 1.015 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.336655e-01 0.874 0 0
PI3K/AKT activation R-HSA-198203 1.886660e-01 0.724 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 1.886660e-01 0.724 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.116457e-01 0.952 0 0
CREB phosphorylation R-HSA-199920 2.759164e-01 0.559 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 2.759164e-01 0.559 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 2.759164e-01 0.559 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 7.885090e-02 1.103 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 2.178688e-01 0.662 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.178688e-01 0.662 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.762645e-01 0.754 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.762645e-01 0.754 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.446758e-01 0.840 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 1.000659e-01 1.000 0 0
Deadenylation of mRNA R-HSA-429947 1.342576e-01 0.872 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.625926e-01 0.789 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.625926e-01 0.789 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.625926e-01 0.789 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.625926e-01 0.789 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.625926e-01 0.789 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.990895e-01 0.701 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.479130e-01 0.606 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.479130e-01 0.606 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.179255e-01 0.498 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.179255e-01 0.498 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 3.179255e-01 0.498 0 0
Regulation of PTEN localization R-HSA-8948747 3.179255e-01 0.498 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.179255e-01 0.498 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 3.179255e-01 0.498 0 0
SOS-mediated signalling R-HSA-112412 3.179255e-01 0.498 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 3.179255e-01 0.498 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 4.363231e-01 0.360 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.363231e-01 0.360 0 0
Defective ABCA1 causes TGD R-HSA-5682113 4.363231e-01 0.360 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.363231e-01 0.360 0 0
Defective ABCA3 causes SMDP3 R-HSA-5683678 4.363231e-01 0.360 0 0
Invadopodia formation R-HSA-8941237 4.363231e-01 0.360 0 0
Defective ABCA3 causes SMDP3 R-HSA-5688399 4.363231e-01 0.360 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 4.363231e-01 0.360 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 4.363231e-01 0.360 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 1.240827e-01 0.906 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.493828e-01 0.826 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.493828e-01 0.826 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.227395e-01 0.652 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.785292e-01 0.555 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.785292e-01 0.555 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.785292e-01 0.555 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.785292e-01 0.555 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.785292e-01 0.555 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.785292e-01 0.555 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 1.258209e-01 0.900 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.008475e-01 0.697 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 8.971050e-02 1.047 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.817591e-01 0.741 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.817591e-01 0.741 0 0
Formation of annular gap junctions R-HSA-196025 3.593337e-01 0.445 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 9.761075e-02 1.011 0 0
Meiotic synapsis R-HSA-1221632 9.761075e-02 1.011 0 0
HIV elongation arrest and recovery R-HSA-167287 1.989086e-01 0.701 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.989086e-01 0.701 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.094689e-01 0.509 0 0
Formation of axial mesoderm R-HSA-9796292 3.094689e-01 0.509 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.094689e-01 0.509 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.798230e-01 0.745 0 0
PKA activation in glucagon signalling R-HSA-164378 2.719376e-01 0.566 0 0
Late endosomal microautophagy R-HSA-9615710 2.166257e-01 0.664 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.166257e-01 0.664 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.951852e-01 0.710 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.951852e-01 0.710 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.766150e-01 0.753 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.766150e-01 0.753 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.972044e-01 0.527 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 3.405060e-01 0.468 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 3.405060e-01 0.468 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.997786e-01 0.398 0 0
Gap junction degradation R-HSA-190873 3.997786e-01 0.398 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 3.997786e-01 0.398 0 0
WNT mediated activation of DVL R-HSA-201688 3.997786e-01 0.398 0 0
MTF1 activates gene expression R-HSA-5660489 4.973948e-01 0.303 0 0
Regulation of gap junction activity R-HSA-191650 4.973948e-01 0.303 0 0
NADE modulates death signalling R-HSA-205025 4.973948e-01 0.303 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.973948e-01 0.303 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.973948e-01 0.303 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.973948e-01 0.303 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.973948e-01 0.303 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.973948e-01 0.303 0 0
Defective CP causes aceruloplasminemia (ACERULOP) R-HSA-5619060 4.973948e-01 0.303 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.278266e-01 0.893 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.273602e-01 0.643 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.494110e-01 0.826 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.846589e-01 0.546 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.454404e-01 0.837 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.187429e-01 0.925 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.035061e-01 0.985 0 0
DCC mediated attractive signaling R-HSA-418885 3.714374e-01 0.430 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.714374e-01 0.430 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 3.714374e-01 0.430 0 0
Centrosome maturation R-HSA-380287 1.642838e-01 0.784 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.977481e-01 0.704 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.977481e-01 0.704 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.919878e-01 0.535 0 0
2-LTR circle formation R-HSA-164843 4.389830e-01 0.358 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.389830e-01 0.358 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 4.389830e-01 0.358 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.575582e-01 0.803 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 2.786119e-01 0.555 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.786119e-01 0.555 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.288147e-01 0.483 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.660521e-01 0.780 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.550782e-01 0.809 0 0
Phosphorylation of the APC/C R-HSA-176412 4.020834e-01 0.396 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 4.020834e-01 0.396 0 0
HIV Transcription Elongation R-HSA-167169 2.963150e-01 0.528 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 2.963150e-01 0.528 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.963150e-01 0.528 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 3.741041e-01 0.427 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.697288e-01 0.569 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.580184e-01 0.588 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 3.315154e-01 0.479 0 0
RAF activation R-HSA-5673000 3.315154e-01 0.479 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 3.315154e-01 0.479 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 3.142521e-01 0.503 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 2.131936e-01 0.671 0 0
HDACs deacetylate histones R-HSA-3214815 3.000903e-01 0.523 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.323778e-01 0.478 0 0
DNA methylation R-HSA-5334118 3.735678e-01 0.428 0 0
FGFR2 alternative splicing R-HSA-6803529 3.997100e-01 0.398 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 3.997100e-01 0.398 0 0
Phase 2 - plateau phase R-HSA-5576893 4.322869e-01 0.364 0 0
Signaling by APC mutants R-HSA-4839744 4.767412e-01 0.322 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.767412e-01 0.322 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.767412e-01 0.322 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.767412e-01 0.322 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 5.518528e-01 0.258 0 0
G2 Phase R-HSA-68911 5.518528e-01 0.258 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 5.518528e-01 0.258 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.515054e-01 0.599 0 0
Viral mRNA Translation R-HSA-192823 2.418815e-01 0.616 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.959728e-01 0.402 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.003704e-01 0.698 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 4.619125e-01 0.335 0 0
snRNP Assembly R-HSA-191859 3.628838e-01 0.440 0 0
Metabolism of non-coding RNA R-HSA-194441 3.628838e-01 0.440 0 0
ERKs are inactivated R-HSA-202670 5.129064e-01 0.290 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 4.404843e-01 0.356 0 0
Ephrin signaling R-HSA-3928664 4.908454e-01 0.309 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 4.908454e-01 0.309 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.243006e-01 0.372 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 4.048904e-01 0.393 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 4.518808e-01 0.345 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 4.076267e-01 0.390 0 0
Striated Muscle Contraction R-HSA-390522 4.841775e-01 0.315 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 5.189901e-01 0.285 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 5.189901e-01 0.285 0 0
p75NTR recruits signalling complexes R-HSA-209543 5.473806e-01 0.262 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.473806e-01 0.262 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 5.473806e-01 0.262 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.473806e-01 0.262 0 0
IRAK1 recruits IKK complex R-HSA-937039 5.473806e-01 0.262 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 5.473806e-01 0.262 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 6.004131e-01 0.222 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 6.004131e-01 0.222 0 0
PDE3B signalling R-HSA-165160 6.004131e-01 0.222 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.004131e-01 0.222 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 6.004131e-01 0.222 0 0
PKB-mediated events R-HSA-109703 6.004131e-01 0.222 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.004131e-01 0.222 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.004131e-01 0.222 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.004131e-01 0.222 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.350735e-01 0.361 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.232003e-01 0.281 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 5.462687e-01 0.263 0 0
Transcription of the HIV genome R-HSA-167172 5.061263e-01 0.296 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 5.464746e-01 0.262 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 5.464746e-01 0.262 0 0
Formation of the Early Elongation Complex R-HSA-113418 5.464746e-01 0.262 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 5.726197e-01 0.242 0 0
Signaling by Erythropoietin R-HSA-9006335 5.691429e-01 0.245 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.691429e-01 0.245 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 5.674465e-01 0.246 0 0
Voltage gated Potassium channels R-HSA-1296072 5.674465e-01 0.246 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.666926e-01 0.247 0 0
Nucleosome assembly R-HSA-774815 5.666926e-01 0.247 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.911654e-01 0.228 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 5.911654e-01 0.228 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 5.979961e-01 0.223 0 0
Prolactin receptor signaling R-HSA-1170546 6.110560e-01 0.214 0 0
Retrograde neurotrophin signalling R-HSA-177504 6.110560e-01 0.214 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.437141e-01 0.191 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.437141e-01 0.191 0 0
Autointegration results in viral DNA circles R-HSA-177539 6.437141e-01 0.191 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.437141e-01 0.191 0 0
PPARA activates gene expression R-HSA-1989781 6.051506e-01 0.218 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 6.125093e-01 0.213 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 6.125093e-01 0.213 0 0
Notch-HLH transcription pathway R-HSA-350054 6.223643e-01 0.206 0 0
Spry regulation of FGF signaling R-HSA-1295596 6.402319e-01 0.194 0 0
Erythropoietin activates RAS R-HSA-9027284 6.402319e-01 0.194 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 6.402319e-01 0.194 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 6.402319e-01 0.194 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 6.402319e-01 0.194 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 6.432327e-01 0.192 0 0
FOXO-mediated transcription R-HSA-9614085 1.370060e-01 0.863 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.631456e-01 0.787 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.273602e-01 0.643 0 0
RNA Polymerase III Transcription R-HSA-74158 1.258209e-01 0.900 0 0
Integrin signaling R-HSA-354192 2.919878e-01 0.535 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 5.357097e-01 0.271 0 0
Developmental Cell Lineages R-HSA-9734767 4.149633e-01 0.382 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.532911e-01 0.814 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 2.610327e-01 0.583 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 2.610327e-01 0.583 0 0
EPH-Ephrin signaling R-HSA-2682334 8.480669e-02 1.072 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.501591e-01 0.823 0 0
Downstream signal transduction R-HSA-186763 6.125093e-01 0.213 0 0
Recycling pathway of L1 R-HSA-437239 6.023315e-01 0.220 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 6.250821e-01 0.204 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 6.250821e-01 0.204 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 2.610327e-01 0.583 0 0
EPHB-mediated forward signaling R-HSA-3928662 8.094223e-02 1.092 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 2.348524e-01 0.629 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 6.125093e-01 0.213 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.008475e-01 0.697 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.550782e-01 0.809 0 0
Signaling by ERBB2 R-HSA-1227986 5.183626e-01 0.285 0 0
EGFR downregulation R-HSA-182971 2.535288e-01 0.596 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.919878e-01 0.535 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 5.462687e-01 0.263 0 0
Telomere Extension By Telomerase R-HSA-171319 5.464746e-01 0.262 0 0
Prolonged ERK activation events R-HSA-169893 8.278097e-02 1.082 0 0
Chromosome Maintenance R-HSA-73886 4.807527e-01 0.318 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 4.322869e-01 0.364 0 0
Signaling by EGFR R-HSA-177929 3.155730e-01 0.501 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.217560e-01 0.915 0 0
Synaptic adhesion-like molecules R-HSA-8849932 1.276701e-01 0.894 0 0
DNA Double Strand Break Response R-HSA-5693606 1.593050e-01 0.798 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.426673e-01 0.846 0 0
Circadian clock R-HSA-9909396 4.327147e-01 0.364 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.813437e-01 0.741 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.110446e-01 0.676 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.278266e-01 0.893 0 0
Integration of provirus R-HSA-162592 5.129064e-01 0.290 0 0
Myogenesis R-HSA-525793 4.993681e-01 0.302 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 6.110560e-01 0.214 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 5.666926e-01 0.247 0 0
Adipogenesis R-HSA-9843745 5.182968e-01 0.285 0 0
Frs2-mediated activation R-HSA-170968 1.336655e-01 0.874 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.798230e-01 0.745 0 0
p75NTR signals via NF-kB R-HSA-193639 6.402319e-01 0.194 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 3.288147e-01 0.483 0 0
Mitotic Prometaphase R-HSA-68877 7.530001e-02 1.123 0 0
MAP2K and MAPK activation R-HSA-5674135 1.155305e-01 0.937 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.649968e-01 0.783 0 0
DARPP-32 events R-HSA-180024 2.166257e-01 0.664 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.144209e-01 0.941 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.364768e-01 0.865 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.919878e-01 0.535 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.389830e-01 0.358 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.596356e-01 0.444 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 4.502621e-01 0.347 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.547117e-01 0.810 0 0
RMTs methylate histone arginines R-HSA-3214858 1.484382e-01 0.828 0 0
Homology Directed Repair R-HSA-5693538 1.313549e-01 0.882 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 4.322869e-01 0.364 0 0
GAB1 signalosome R-HSA-180292 4.908454e-01 0.309 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.790212e-01 0.320 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.790212e-01 0.320 0 0
Nuclear RNA decay R-HSA-9930044 1.649968e-01 0.783 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.501747e-01 0.823 0 0
Peptide chain elongation R-HSA-156902 9.848167e-02 1.007 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 4.020834e-01 0.396 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 3.997100e-01 0.398 0 0
LGI-ADAM interactions R-HSA-5682910 4.767412e-01 0.322 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.624300e-01 0.581 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 5.817497e-01 0.235 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 6.432327e-01 0.192 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 5.194548e-01 0.284 0 0
Pyroptosis R-HSA-5620971 3.511566e-01 0.454 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 3.465829e-01 0.460 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 5.670260e-01 0.246 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.377261e-01 0.861 0 0
RNA Polymerase I Transcription R-HSA-73864 5.245744e-01 0.280 0 0
Formation of definitive endoderm R-HSA-9823730 3.227372e-01 0.491 0 0
Cyclin D associated events in G1 R-HSA-69231 3.874431e-01 0.412 0 0
G1 Phase R-HSA-69236 3.874431e-01 0.412 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.728626e-01 0.762 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.920767e-01 0.717 0 0
Adrenoceptors R-HSA-390696 1.339473e-01 0.873 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 1.605919e-01 0.794 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 2.785292e-01 0.555 0 0
PKA activation R-HSA-163615 2.719376e-01 0.566 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.163565e-01 0.665 0 0
Separation of Sister Chromatids R-HSA-2467813 2.728484e-01 0.564 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 5.473806e-01 0.262 0 0
Opioid Signalling R-HSA-111885 2.522366e-01 0.598 0 0
Regulated Necrosis R-HSA-5218859 6.418693e-01 0.193 0 0
Netrin-1 signaling R-HSA-373752 3.874431e-01 0.412 0 0
G-protein mediated events R-HSA-112040 1.593050e-01 0.798 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.728626e-01 0.762 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.993681e-01 0.302 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.627584e-01 0.580 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.627584e-01 0.580 0 0
Hedgehog 'off' state R-HSA-5610787 5.066157e-01 0.295 0 0
Signaling by FGFR1 in disease R-HSA-5655302 2.049423e-01 0.688 0 0
Long-term potentiation R-HSA-9620244 2.846589e-01 0.546 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.959728e-01 0.402 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 2.328728e-01 0.633 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 5.232003e-01 0.281 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 3.198035e-01 0.495 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.683106e-01 0.774 0 0
Intra-Golgi traffic R-HSA-6811438 4.912171e-01 0.309 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 4.951611e-01 0.305 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 5.871675e-01 0.231 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 4.414157e-01 0.355 0 0
Meiosis R-HSA-1500620 7.505094e-02 1.125 0 0
M Phase R-HSA-68886 8.582776e-02 1.066 0 0
Neurexins and neuroligins R-HSA-6794361 2.549069e-01 0.594 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.567907e-01 0.805 0 0
Calcineurin activates NFAT R-HSA-2025928 1.605919e-01 0.794 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.336655e-01 0.874 0 0
HDL assembly R-HSA-8963896 1.544093e-01 0.811 0 0
Ca2+ activated K+ channels R-HSA-1296052 3.179255e-01 0.498 0 0
Disorders of Developmental Biology R-HSA-9675151 2.227395e-01 0.652 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 2.470697e-01 0.607 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.593337e-01 0.445 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 4.322869e-01 0.364 0 0
Formation of the posterior neural plate R-HSA-9832991 4.767412e-01 0.322 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 4.619125e-01 0.335 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.129064e-01 0.290 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 2.759473e-01 0.559 0 0
Tight junction interactions R-HSA-420029 4.750338e-01 0.323 0 0
Activation of ATR in response to replication stress R-HSA-176187 4.624622e-01 0.335 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 5.189901e-01 0.285 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 5.105384e-01 0.292 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 6.402319e-01 0.194 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.572711e-01 0.340 0 0
PLC beta mediated events R-HSA-112043 1.050708e-01 0.979 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.668013e-01 0.778 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 2.401438e-01 0.620 0 0
Triglyceride catabolism R-HSA-163560 5.472522e-01 0.262 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.714806e-01 0.430 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 4.841775e-01 0.315 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.572711e-01 0.340 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 4.924371e-01 0.308 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 5.221791e-01 0.282 0 0
Death Receptor Signaling R-HSA-73887 1.402705e-01 0.853 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 4.676452e-01 0.330 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.744580e-01 0.562 0 0
Signaling by FGFR in disease R-HSA-1226099 4.653058e-01 0.332 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.714806e-01 0.430 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.714806e-01 0.430 0 0
Host Interactions of HIV factors R-HSA-162909 6.162814e-01 0.210 0 0
mTORC1-mediated signalling R-HSA-166208 1.063538e-01 0.973 0 0
Acyl chain remodelling of PS R-HSA-1482801 2.846589e-01 0.546 0 0
Signalling to ERKs R-HSA-187687 3.515303e-01 0.454 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 4.924371e-01 0.308 0 0
Mitotic Prophase R-HSA-68875 1.449603e-01 0.839 0 0
Membrane Trafficking R-HSA-199991 5.018200e-01 0.299 0 0
Gastrulation R-HSA-9758941 4.526147e-01 0.344 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 8.941596e-02 1.049 0 0
HIV Life Cycle R-HSA-162587 5.357097e-01 0.271 0 0
HIV Infection R-HSA-162906 6.241630e-01 0.205 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.984683e-01 0.702 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.785292e-01 0.555 0 0
Disorders of Nervous System Development R-HSA-9697154 2.785292e-01 0.555 0 0
Pervasive developmental disorders R-HSA-9005895 2.785292e-01 0.555 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.649968e-01 0.783 0 0
Lipophagy R-HSA-9613354 3.997786e-01 0.398 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 4.973948e-01 0.303 0 0
Eukaryotic Translation Termination R-HSA-72764 1.660521e-01 0.780 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.518528e-01 0.258 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 5.518528e-01 0.258 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 4.619125e-01 0.335 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.628838e-01 0.440 0 0
Mitotic Anaphase R-HSA-68882 1.921785e-01 0.716 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.367419e-01 0.626 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.912171e-01 0.309 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 5.098340e-01 0.293 0 0
G2/M Checkpoints R-HSA-69481 5.611748e-01 0.251 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.008568e-01 0.300 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 4.280057e-01 0.369 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 5.705755e-01 0.244 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 9.604585e-02 1.018 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 2.227395e-01 0.652 0 0
PTEN Regulation R-HSA-6807070 2.592206e-01 0.586 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.716515e-01 0.326 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 6.250821e-01 0.204 0 0
Developmental Biology R-HSA-1266738 9.079514e-02 1.042 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 4.421164e-01 0.354 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 5.129064e-01 0.290 0 0
Signaling by WNT R-HSA-195721 6.189672e-01 0.208 0 0
Response of endothelial cells to shear stress R-HSA-9860931 4.471659e-01 0.350 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 4.269220e-01 0.370 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.389587e-01 0.622 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.520281e-01 0.599 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 5.489909e-01 0.260 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 3.749594e-01 0.426 0 0
Diseases of programmed cell death R-HSA-9645723 1.541585e-01 0.812 0 0
Nuclear Envelope Breakdown R-HSA-2980766 3.312186e-01 0.480 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 5.390715e-01 0.268 0 0
DAG and IP3 signaling R-HSA-1489509 1.603475e-01 0.795 0 0
G-protein beta:gamma signalling R-HSA-397795 4.624622e-01 0.335 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.534176e-01 0.452 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.615569e-01 0.792 0 0
G0 and Early G1 R-HSA-1538133 1.507430e-01 0.822 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.861667e-01 0.543 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 5.344357e-01 0.272 0 0
Post NMDA receptor activation events R-HSA-438064 1.456784e-01 0.837 0 0
MyD88-independent TLR4 cascade R-HSA-166166 5.344357e-01 0.272 0 0
G2/M Transition R-HSA-69275 2.000291e-01 0.699 0 0
Inhibition of PKR R-HSA-169131 2.049007e-01 0.688 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.910307e-01 0.536 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 1.339473e-01 0.873 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 1.605919e-01 0.794 0 0
Bicarbonate transporters R-HSA-425381 2.178688e-01 0.662 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.762645e-01 0.754 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 4.363231e-01 0.360 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.363231e-01 0.360 0 0
MET interacts with TNS proteins R-HSA-8875513 4.363231e-01 0.360 0 0
TGFBR3 expression R-HSA-9839394 1.493828e-01 0.826 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.008475e-01 0.697 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.719376e-01 0.566 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 3.405060e-01 0.468 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.547117e-01 0.810 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 4.389830e-01 0.358 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.735678e-01 0.428 0 0
Ionotropic activity of kainate receptors R-HSA-451306 4.767412e-01 0.322 0 0
Reelin signalling pathway R-HSA-8866376 5.518528e-01 0.258 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 4.251266e-01 0.371 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 3.917750e-01 0.407 0 0
Meiotic recombination R-HSA-912446 3.660426e-01 0.436 0 0
MET promotes cell motility R-HSA-8875878 4.118959e-01 0.385 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 5.129064e-01 0.290 0 0
Signaling by AMER1 mutants R-HSA-4839748 5.129064e-01 0.290 0 0
Signaling by AXIN mutants R-HSA-4839735 5.129064e-01 0.290 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.319472e-01 0.365 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 4.151142e-01 0.382 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 5.473806e-01 0.262 0 0
NGF-independant TRKA activation R-HSA-187024 6.004131e-01 0.222 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.004131e-01 0.222 0 0
Formation of the Editosome R-HSA-75094 6.004131e-01 0.222 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 6.004131e-01 0.222 0 0
Ceramide signalling R-HSA-193681 6.004131e-01 0.222 0 0
Phosphorylation of Emi1 R-HSA-176417 6.004131e-01 0.222 0 0
Synthesis of PS R-HSA-1483101 6.004131e-01 0.222 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 5.232003e-01 0.281 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 5.105384e-01 0.292 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.555247e-01 0.341 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 5.464746e-01 0.262 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.801057e-01 0.236 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 5.801057e-01 0.236 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 5.294424e-01 0.276 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 5.297450e-01 0.276 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 5.297450e-01 0.276 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 5.691429e-01 0.245 0 0
rRNA processing R-HSA-72312 5.916595e-01 0.228 0 0
cGMP effects R-HSA-418457 6.110560e-01 0.214 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 6.250821e-01 0.204 0 0
Interleukin-1 family signaling R-HSA-446652 4.840302e-01 0.315 0 0
Signaling by NTRKs R-HSA-166520 7.308230e-02 1.136 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 4.053672e-01 0.392 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.723760e-01 0.326 0 0
Cell junction organization R-HSA-446728 4.657044e-01 0.332 0 0
Chaperone Mediated Autophagy R-HSA-9613829 4.908454e-01 0.309 0 0
DNA Repair R-HSA-73894 6.156353e-01 0.211 0 0
Glycogen metabolism R-HSA-8982491 6.250821e-01 0.204 0 0
S Phase R-HSA-69242 6.251088e-01 0.204 0 0
Muscle contraction R-HSA-397014 1.260496e-01 0.899 0 0
Ion homeostasis R-HSA-5578775 1.237067e-01 0.908 0 0
MAP kinase activation R-HSA-450294 2.719805e-01 0.565 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 4.423722e-01 0.354 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 4.058844e-01 0.392 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 6.402319e-01 0.194 0 0
Cardiogenesis R-HSA-9733709 1.649968e-01 0.783 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.335235e-01 0.874 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.152262e-01 0.501 0 0
Smooth Muscle Contraction R-HSA-445355 4.002199e-01 0.398 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 4.750338e-01 0.323 0 0
MAPK family signaling cascades R-HSA-5683057 2.903604e-01 0.537 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 3.849010e-01 0.415 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.004338e-01 0.522 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.605919e-01 0.794 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 8.395606e-02 1.076 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 9.726599e-02 1.012 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.997786e-01 0.398 0 0
Signal attenuation R-HSA-74749 4.389830e-01 0.358 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.741041e-01 0.427 0 0
Interleukin-17 signaling R-HSA-448424 4.048904e-01 0.393 0 0
Rab regulation of trafficking R-HSA-9007101 4.337047e-01 0.363 0 0
TBC/RABGAPs R-HSA-8854214 5.295795e-01 0.276 0 0
Cellular response to starvation R-HSA-9711097 5.458848e-01 0.263 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.352669e-01 0.197 0 0
Cardiac conduction R-HSA-5576891 1.834215e-01 0.737 0 0
Formation of the nephric duct R-HSA-9830364 1.493828e-01 0.826 0 0
Programmed Cell Death R-HSA-5357801 2.878969e-01 0.541 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 6.125093e-01 0.213 0 0
Signaling by VEGF R-HSA-194138 4.389380e-01 0.358 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.179255e-01 0.498 0 0
Interleukin-1 processing R-HSA-448706 3.997786e-01 0.398 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.973948e-01 0.303 0 0
Protein hydroxylation R-HSA-9629569 3.227372e-01 0.491 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.629189e-01 0.788 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.518528e-01 0.258 0 0
Syndecan interactions R-HSA-3000170 4.251266e-01 0.371 0 0
Signaling by LTK R-HSA-9842663 5.473806e-01 0.262 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 6.004131e-01 0.222 0 0
GPVI-mediated activation cascade R-HSA-114604 5.472522e-01 0.262 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 6.110560e-01 0.214 0 0
Signaling by PTK6 R-HSA-8848021 3.005539e-01 0.522 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.005539e-01 0.522 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.155730e-01 0.501 0 0
NOD1/2 Signaling Pathway R-HSA-168638 5.055781e-01 0.296 0 0
Amine ligand-binding receptors R-HSA-375280 5.483074e-01 0.261 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 3.142521e-01 0.503 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 3.094689e-01 0.509 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 3.997786e-01 0.398 0 0
HSF1-dependent transactivation R-HSA-3371571 5.147179e-01 0.288 0 0
Cellular responses to stimuli R-HSA-8953897 5.722972e-01 0.242 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 4.908454e-01 0.309 0 0
Cellular responses to stress R-HSA-2262752 5.925386e-01 0.227 0 0
Aquaporin-mediated transport R-HSA-445717 5.346767e-01 0.272 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.259233e-01 0.371 0 0
L1CAM interactions R-HSA-373760 3.261493e-01 0.487 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.187429e-01 0.925 0 0
Uptake and function of anthrax toxins R-HSA-5210891 4.619125e-01 0.335 0 0
Glycolysis R-HSA-70171 1.445935e-01 0.840 0 0
Kidney development R-HSA-9830369 3.596356e-01 0.444 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.910307e-01 0.536 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.910307e-01 0.536 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.337714e-01 0.631 0 0
DSCAM interactions R-HSA-376172 3.678351e-01 0.434 0 0
Formation of the anterior neural plate R-HSA-9823739 1.762645e-01 0.754 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 8.395606e-02 1.076 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 4.363231e-01 0.360 0 0
Alpha-defensins R-HSA-1462054 3.593337e-01 0.445 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 3.405060e-01 0.468 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 4.973948e-01 0.303 0 0
Sensory perception of sour taste R-HSA-9729555 4.973948e-01 0.303 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.861325e-01 0.730 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 4.322869e-01 0.364 0 0
Synthesis of PI R-HSA-1483226 4.767412e-01 0.322 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 5.518528e-01 0.258 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 5.518528e-01 0.258 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 4.624622e-01 0.335 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.004131e-01 0.222 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.004131e-01 0.222 0 0
Creatine metabolism R-HSA-71288 5.462687e-01 0.263 0 0
Early Phase of HIV Life Cycle R-HSA-162594 5.726197e-01 0.242 0 0
Regulation of gene expression in beta cells R-HSA-210745 5.691429e-01 0.245 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.437141e-01 0.191 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 6.437141e-01 0.191 0 0
Signaling by NOTCH3 R-HSA-9012852 5.831805e-01 0.234 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 3.959728e-01 0.402 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.446758e-01 0.840 0 0
Plasma lipoprotein assembly R-HSA-8963898 4.502621e-01 0.347 0 0
Stimuli-sensing channels R-HSA-2672351 4.036702e-01 0.394 0 0
ISG15 antiviral mechanism R-HSA-1169408 4.802795e-01 0.319 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.629442e-01 0.580 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.652329e-01 0.782 0 0
Apoptosis R-HSA-109581 2.558981e-01 0.592 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.605919e-01 0.794 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 4.851831e-01 0.314 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 4.404843e-01 0.356 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 1.813437e-01 0.741 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.759164e-01 0.559 0 0
Histamine receptors R-HSA-390650 4.363231e-01 0.360 0 0
Selenocysteine synthesis R-HSA-2408557 2.217075e-01 0.654 0 0
PI Metabolism R-HSA-1483255 5.321981e-01 0.274 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 5.726197e-01 0.242 0 0
Diseases of DNA repair R-HSA-9675135 4.243006e-01 0.372 0 0
Signaling by TGFBR3 R-HSA-9839373 4.243006e-01 0.372 0 0
Signaling by TGFB family members R-HSA-9006936 5.660257e-01 0.247 0 0
NrCAM interactions R-HSA-447038 1.920767e-01 0.717 0 0
Activation of RAC1 R-HSA-428540 9.604585e-02 1.018 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.179255e-01 0.498 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 3.179255e-01 0.498 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 4.363231e-01 0.360 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 4.363231e-01 0.360 0 0
Sodium/Proton exchangers R-HSA-425986 3.593337e-01 0.445 0 0
Interleukin-18 signaling R-HSA-9012546 3.593337e-01 0.445 0 0
Dopamine receptors R-HSA-390651 4.973948e-01 0.303 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.973948e-01 0.303 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 5.518528e-01 0.258 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.518528e-01 0.258 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.522366e-01 0.598 0 0
Estrogen biosynthesis R-HSA-193144 5.473806e-01 0.262 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 6.004131e-01 0.222 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.004131e-01 0.222 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 5.464746e-01 0.262 0 0
NADPH regeneration R-HSA-389542 6.437141e-01 0.191 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.437141e-01 0.191 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 7.187363e-02 1.143 0 0
Glucose metabolism R-HSA-70326 2.519323e-01 0.599 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 5.473806e-01 0.262 0 0
RUNX2 regulates bone development R-HSA-8941326 5.472522e-01 0.262 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.762645e-01 0.754 0 0
OAS antiviral response R-HSA-8983711 2.785292e-01 0.555 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 6.004131e-01 0.222 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 6.004131e-01 0.222 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 6.004131e-01 0.222 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 6.004131e-01 0.222 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 6.004131e-01 0.222 0 0
Lipid particle organization R-HSA-8964572 6.437141e-01 0.191 0 0
Leukotriene receptors R-HSA-391906 6.437141e-01 0.191 0 0
Signaling by Interleukins R-HSA-449147 5.662512e-01 0.247 0 0
Interleukin-7 signaling R-HSA-1266695 1.493828e-01 0.826 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 4.974111e-01 0.303 0 0
Influenza Infection R-HSA-168255 4.196904e-01 0.377 0 0
Signaling by ALK in cancer R-HSA-9700206 4.974111e-01 0.303 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.719376e-01 0.566 0 0
Metal ion SLC transporters R-HSA-425410 6.195411e-01 0.208 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.886660e-01 0.724 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 6.004131e-01 0.222 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.518528e-01 0.258 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 6.402319e-01 0.194 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.298359e-01 0.482 0 0
XBP1(S) activates chaperone genes R-HSA-381038 4.076267e-01 0.390 0 0
IRE1alpha activates chaperones R-HSA-381070 4.896488e-01 0.310 0 0
Signaling by Leptin R-HSA-2586552 4.389830e-01 0.358 0 0
Interleukin-12 signaling R-HSA-9020591 4.951611e-01 0.305 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 4.908454e-01 0.309 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 6.223643e-01 0.206 0 0
Formation of the ureteric bud R-HSA-9830674 6.457023e-01 0.190 0 0
Growth hormone receptor signaling R-HSA-982772 6.457023e-01 0.190 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 6.489965e-01 0.188 0 0
Nuclear Receptor transcription pathway R-HSA-383280 6.516334e-01 0.186 0 0
PI3K Cascade R-HSA-109704 6.526520e-01 0.185 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 6.530648e-01 0.185 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 6.530648e-01 0.185 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 6.530648e-01 0.185 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 6.530648e-01 0.185 0 0
Late Phase of HIV Life Cycle R-HSA-162599 6.555732e-01 0.183 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 6.584596e-01 0.181 0 0
Interleukin-12 family signaling R-HSA-447115 6.606988e-01 0.180 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 6.608236e-01 0.180 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 6.608236e-01 0.180 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 6.608236e-01 0.180 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 6.637301e-01 0.178 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 6.676544e-01 0.175 0 0
Phase 4 - resting membrane potential R-HSA-5576886 6.676544e-01 0.175 0 0
Regulation of BACH1 activity R-HSA-9708530 6.676544e-01 0.175 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 6.676544e-01 0.175 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.676544e-01 0.175 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.676544e-01 0.175 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.676544e-01 0.175 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 6.679984e-01 0.175 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 6.679984e-01 0.175 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 6.697890e-01 0.174 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.697890e-01 0.174 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 6.722433e-01 0.172 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 6.722433e-01 0.172 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 6.722433e-01 0.172 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 6.722433e-01 0.172 0 0
Acyl chain remodelling of PC R-HSA-1482788 6.722433e-01 0.172 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 6.722433e-01 0.172 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 6.760166e-01 0.170 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 6.823250e-01 0.166 0 0
Netrin mediated repulsion signals R-HSA-418886 6.823250e-01 0.166 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.823250e-01 0.166 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.823250e-01 0.166 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.823250e-01 0.166 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 6.823250e-01 0.166 0 0
Disinhibition of SNARE formation R-HSA-114516 6.823250e-01 0.166 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 6.823250e-01 0.166 0 0
mRNA Editing: C to U Conversion R-HSA-72200 6.823250e-01 0.166 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.823250e-01 0.166 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.823250e-01 0.166 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 6.823250e-01 0.166 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.823250e-01 0.166 0 0
VLDL clearance R-HSA-8964046 6.823250e-01 0.166 0 0
Activation of TRKA receptors R-HSA-187015 6.823250e-01 0.166 0 0
Glycoprotein hormones R-HSA-209822 6.823250e-01 0.166 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.823250e-01 0.166 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 6.839322e-01 0.165 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 6.906760e-01 0.161 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.906760e-01 0.161 0 0
Nuclear import of Rev protein R-HSA-180746 6.906760e-01 0.161 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 6.906760e-01 0.161 0 0
Telomere Maintenance R-HSA-157579 6.921738e-01 0.160 0 0
Toll-like Receptor Cascades R-HSA-168898 6.927336e-01 0.159 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 6.933608e-01 0.159 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 6.933608e-01 0.159 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 6.933608e-01 0.159 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 6.933608e-01 0.159 0 0
Passive transport by Aquaporins R-HSA-432047 6.933608e-01 0.159 0 0
Synthesis of PG R-HSA-1483148 6.933608e-01 0.159 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 6.933608e-01 0.159 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 6.934563e-01 0.159 0 0
Defective pyroptosis R-HSA-9710421 6.942822e-01 0.158 0 0
Ribosome-associated quality control R-HSA-9948299 6.959216e-01 0.157 0 0
Ub-specific processing proteases R-HSA-5689880 6.960575e-01 0.157 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 6.963507e-01 0.157 0 0
Deubiquitination R-HSA-5688426 6.994483e-01 0.155 0 0
Regulation of insulin secretion R-HSA-422356 7.033001e-01 0.153 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 7.038905e-01 0.152 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 7.083596e-01 0.150 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 7.083596e-01 0.150 0 0
Acyl chain remodelling of PE R-HSA-1482839 7.083596e-01 0.150 0 0
Oncogene Induced Senescence R-HSA-2559585 7.083596e-01 0.150 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 7.083866e-01 0.150 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 7.094625e-01 0.149 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.094625e-01 0.149 0 0
phospho-PLA2 pathway R-HSA-111995 7.167536e-01 0.145 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.167536e-01 0.145 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.167536e-01 0.145 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 7.167536e-01 0.145 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.167536e-01 0.145 0 0
MET receptor recycling R-HSA-8875656 7.167536e-01 0.145 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 7.167536e-01 0.145 0 0
Regulation by c-FLIP R-HSA-3371378 7.167536e-01 0.145 0 0
Co-stimulation by ICOS R-HSA-9927354 7.167536e-01 0.145 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.167536e-01 0.145 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 7.167536e-01 0.145 0 0
Dimerization of procaspase-8 R-HSA-69416 7.167536e-01 0.145 0 0
IGF1R signaling cascade R-HSA-2428924 7.172169e-01 0.144 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 7.172169e-01 0.144 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 7.174011e-01 0.144 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 7.174011e-01 0.144 0 0
FLT3 signaling in disease R-HSA-9682385 7.252946e-01 0.139 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 7.254029e-01 0.139 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 7.254029e-01 0.139 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 7.254029e-01 0.139 0 0
Fanconi Anemia Pathway R-HSA-6783310 7.254029e-01 0.139 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 7.254029e-01 0.139 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.286478e-01 0.137 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.286478e-01 0.137 0 0
Packaging Of Telomere Ends R-HSA-171306 7.286478e-01 0.137 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 7.286478e-01 0.137 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 7.301317e-01 0.137 0 0
Mitochondrial biogenesis R-HSA-1592230 7.348502e-01 0.134 0 0
Cell-cell junction organization R-HSA-421270 7.350738e-01 0.134 0 0
Cell-Cell communication R-HSA-1500931 7.386961e-01 0.132 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 7.398343e-01 0.131 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 7.398343e-01 0.131 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 7.398343e-01 0.131 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 7.398343e-01 0.131 0 0
Presynaptic function of Kainate receptors R-HSA-500657 7.398343e-01 0.131 0 0
Apoptotic factor-mediated response R-HSA-111471 7.398343e-01 0.131 0 0
Platelet sensitization by LDL R-HSA-432142 7.398343e-01 0.131 0 0
Nephron development R-HSA-9831926 7.398343e-01 0.131 0 0
Regulation of TNFR1 signaling R-HSA-5357905 7.400822e-01 0.131 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 7.400822e-01 0.131 0 0
TNF signaling R-HSA-75893 7.407598e-01 0.130 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 7.414859e-01 0.130 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 7.468233e-01 0.127 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.474528e-01 0.126 0 0
CASP8 activity is inhibited R-HSA-5218900 7.474528e-01 0.126 0 0
ALK mutants bind TKIs R-HSA-9700645 7.474528e-01 0.126 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.474528e-01 0.126 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.474528e-01 0.126 0 0
Unwinding of DNA R-HSA-176974 7.474528e-01 0.126 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.474528e-01 0.126 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 7.474528e-01 0.126 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.474528e-01 0.126 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.474528e-01 0.126 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.474528e-01 0.126 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.474528e-01 0.126 0 0
mRNA Editing R-HSA-75072 7.474528e-01 0.126 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.474528e-01 0.126 0 0
GP1b-IX-V activation signalling R-HSA-430116 7.474528e-01 0.126 0 0
Clathrin-mediated endocytosis R-HSA-8856828 7.490960e-01 0.125 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.533859e-01 0.123 0 0
IRS-mediated signalling R-HSA-112399 7.537565e-01 0.123 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 7.541771e-01 0.123 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.559065e-01 0.122 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 7.607263e-01 0.119 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 7.607263e-01 0.119 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 7.607263e-01 0.119 0 0
The NLRP3 inflammasome R-HSA-844456 7.607263e-01 0.119 0 0
Regulation of signaling by CBL R-HSA-912631 7.607263e-01 0.119 0 0
Integration of energy metabolism R-HSA-163685 7.614402e-01 0.118 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.616754e-01 0.118 0 0
Adherens junctions interactions R-HSA-418990 7.627823e-01 0.118 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 7.640116e-01 0.117 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 7.640116e-01 0.117 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 7.640116e-01 0.117 0 0
Platelet calcium homeostasis R-HSA-418360 7.640116e-01 0.117 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 7.646593e-01 0.117 0 0
Co-stimulation by CD28 R-HSA-389356 7.676925e-01 0.115 0 0
Cellular response to heat stress R-HSA-3371556 7.710337e-01 0.113 0 0
Signaling by ALK R-HSA-201556 7.716720e-01 0.113 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.748263e-01 0.111 0 0
Formation of apoptosome R-HSA-111458 7.748263e-01 0.111 0 0
Regulation of CDH11 function R-HSA-9762292 7.748263e-01 0.111 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 7.748263e-01 0.111 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.748263e-01 0.111 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 7.748263e-01 0.111 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.748263e-01 0.111 0 0
Formation of intermediate mesoderm R-HSA-9761174 7.748263e-01 0.111 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.748263e-01 0.111 0 0
Maturation of spike protein R-HSA-9683686 7.748263e-01 0.111 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 7.748263e-01 0.111 0 0
Peptide hormone biosynthesis R-HSA-209952 7.748263e-01 0.111 0 0
Tandem pore domain potassium channels R-HSA-1296346 7.748263e-01 0.111 0 0
Signaling by Hedgehog R-HSA-5358351 7.776448e-01 0.109 0 0
Extension of Telomeres R-HSA-180786 7.783076e-01 0.109 0 0
Triglyceride metabolism R-HSA-8979227 7.783076e-01 0.109 0 0
Regulation of beta-cell development R-HSA-186712 7.783076e-01 0.109 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.801477e-01 0.108 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 7.801477e-01 0.108 0 0
Signaling by NODAL R-HSA-1181150 7.801477e-01 0.108 0 0
Activation of BH3-only proteins R-HSA-114452 7.802387e-01 0.108 0 0
Potassium Channels R-HSA-1296071 7.809758e-01 0.107 0 0
Aggrephagy R-HSA-9646399 7.856914e-01 0.105 0 0
Diseases of Immune System R-HSA-5260271 7.856914e-01 0.105 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.856914e-01 0.105 0 0
Signaling by FGFR2 R-HSA-5654738 7.883489e-01 0.103 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 7.883489e-01 0.103 0 0
SARS-CoV-1-host interactions R-HSA-9692914 7.918082e-01 0.101 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.955340e-01 0.099 0 0
Budding and maturation of HIV virion R-HSA-162588 7.955340e-01 0.099 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 7.955340e-01 0.099 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 7.981717e-01 0.098 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 7.981717e-01 0.098 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.981717e-01 0.098 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.981717e-01 0.098 0 0
Acyl chain remodelling of PG R-HSA-1482925 7.981717e-01 0.098 0 0
ERK/MAPK targets R-HSA-198753 7.981717e-01 0.098 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 7.981717e-01 0.098 0 0
Hedgehog 'on' state R-HSA-5632684 7.989733e-01 0.097 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 7.990154e-01 0.097 0 0
FLT3 Signaling R-HSA-9607240 7.990154e-01 0.097 0 0
ChREBP activates metabolic gene expression R-HSA-163765 7.992342e-01 0.097 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 7.992342e-01 0.097 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 7.992342e-01 0.097 0 0
FGFR2b ligand binding and activation R-HSA-190377 7.992342e-01 0.097 0 0
Interleukin-2 signaling R-HSA-9020558 7.992342e-01 0.097 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 7.992342e-01 0.097 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.992342e-01 0.097 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.992342e-01 0.097 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 7.992342e-01 0.097 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.992342e-01 0.097 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 7.992342e-01 0.097 0 0
Suppression of apoptosis R-HSA-9635465 7.992342e-01 0.097 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 8.048393e-01 0.094 0 0
Signaling by WNT in cancer R-HSA-4791275 8.099293e-01 0.092 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 8.099293e-01 0.092 0 0
tRNA processing in the nucleus R-HSA-6784531 8.116039e-01 0.091 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 8.116613e-01 0.091 0 0
Ion channel transport R-HSA-983712 8.132144e-01 0.090 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 8.148730e-01 0.089 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 8.148730e-01 0.089 0 0
Mitochondrial calcium ion transport R-HSA-8949215 8.148730e-01 0.089 0 0
Glutathione synthesis and recycling R-HSA-174403 8.148730e-01 0.089 0 0
Assembly Of The HIV Virion R-HSA-175474 8.148730e-01 0.089 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.169641e-01 0.088 0 0
Ca2+ pathway R-HSA-4086398 8.186942e-01 0.087 0 0
Cilium Assembly R-HSA-5617833 8.193034e-01 0.087 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 8.209977e-01 0.086 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 8.209977e-01 0.086 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.209977e-01 0.086 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.209977e-01 0.086 0 0
NF-kB is activated and signals survival R-HSA-209560 8.209977e-01 0.086 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 8.209977e-01 0.086 0 0
Sodium/Calcium exchangers R-HSA-425561 8.209977e-01 0.086 0 0
Uptake of dietary cobalamins into enterocytes R-HSA-9758881 8.209977e-01 0.086 0 0
Cytokine Signaling in Immune system R-HSA-1280215 8.226178e-01 0.085 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 8.234581e-01 0.084 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.234581e-01 0.084 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 8.236485e-01 0.084 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.236485e-01 0.084 0 0
Depyrimidination R-HSA-73928 8.236485e-01 0.084 0 0
TCR signaling R-HSA-202403 8.243781e-01 0.084 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 8.268753e-01 0.083 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 8.297807e-01 0.081 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.303265e-01 0.081 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.303265e-01 0.081 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 8.303265e-01 0.081 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 8.303265e-01 0.081 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 8.303265e-01 0.081 0 0
LDL clearance R-HSA-8964038 8.303265e-01 0.081 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 8.303265e-01 0.081 0 0
Insulin receptor signalling cascade R-HSA-74751 8.315338e-01 0.080 0 0
Assembly of the pre-replicative complex R-HSA-68867 8.328100e-01 0.079 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 8.343263e-01 0.079 0 0
Signaling by FGFR4 R-HSA-5654743 8.349972e-01 0.078 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 8.361555e-01 0.078 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.361555e-01 0.078 0 0
Translation initiation complex formation R-HSA-72649 8.371125e-01 0.077 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 8.371125e-01 0.077 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 8.404031e-01 0.076 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 8.404031e-01 0.076 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.404031e-01 0.076 0 0
Repression of WNT target genes R-HSA-4641265 8.404031e-01 0.076 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.404031e-01 0.076 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.404031e-01 0.076 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.404031e-01 0.076 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.404031e-01 0.076 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.404031e-01 0.076 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 8.404031e-01 0.076 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.404031e-01 0.076 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 8.404031e-01 0.076 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.404031e-01 0.076 0 0
Autophagy R-HSA-9612973 8.421279e-01 0.075 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 8.446065e-01 0.073 0 0
Carnitine shuttle R-HSA-200425 8.446065e-01 0.073 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 8.446065e-01 0.073 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 8.446065e-01 0.073 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.450747e-01 0.073 0 0
Signaling by NOTCH1 R-HSA-1980143 8.454044e-01 0.073 0 0
Signaling by NOTCH2 R-HSA-1980145 8.480570e-01 0.072 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 8.480570e-01 0.072 0 0
Organelle biogenesis and maintenance R-HSA-1852241 8.536841e-01 0.069 0 0
Signaling by FGFR3 R-HSA-5654741 8.558650e-01 0.068 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 8.560968e-01 0.067 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 8.560968e-01 0.067 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.577058e-01 0.067 0 0
FGFR2c ligand binding and activation R-HSA-190375 8.577058e-01 0.067 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 8.577058e-01 0.067 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.577058e-01 0.067 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.577058e-01 0.067 0 0
FGFR4 ligand binding and activation R-HSA-190322 8.577058e-01 0.067 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 8.577058e-01 0.067 0 0
Chylomicron remodeling R-HSA-8963901 8.577058e-01 0.067 0 0
Mtb iron assimilation by chelation R-HSA-1222449 8.577058e-01 0.067 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 8.577058e-01 0.067 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.577058e-01 0.067 0 0
FGFR3 mutant receptor activation R-HSA-2033514 8.577058e-01 0.067 0 0
Processing of SMDT1 R-HSA-8949664 8.577058e-01 0.067 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 8.577058e-01 0.067 0 0
rRNA modification in the mitochondrion R-HSA-6793080 8.577058e-01 0.067 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.577058e-01 0.067 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.577058e-01 0.067 0 0
Maturation of nucleoprotein R-HSA-9683610 8.577058e-01 0.067 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 8.577856e-01 0.067 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.577856e-01 0.067 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 8.577856e-01 0.067 0 0
Interferon gamma signaling R-HSA-877300 8.593636e-01 0.066 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 8.625002e-01 0.064 0 0
Macroautophagy R-HSA-1632852 8.642919e-01 0.063 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.654287e-01 0.063 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.654287e-01 0.063 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.696175e-01 0.061 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.696175e-01 0.061 0 0
G1/S-Specific Transcription R-HSA-69205 8.696175e-01 0.061 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.699346e-01 0.061 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.699346e-01 0.061 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.699346e-01 0.061 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 8.731336e-01 0.059 0 0
NRIF signals cell death from the nucleus R-HSA-205043 8.731336e-01 0.059 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.731336e-01 0.059 0 0
FGFR3c ligand binding and activation R-HSA-190372 8.731336e-01 0.059 0 0
Signaling by FGFR4 in disease R-HSA-5655291 8.731336e-01 0.059 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 8.731336e-01 0.059 0 0
Hydrolysis of LPC R-HSA-1483115 8.731336e-01 0.059 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 8.731336e-01 0.059 0 0
Removal of the Flap Intermediate R-HSA-69166 8.731336e-01 0.059 0 0
Vitamin B2 (riboflavin) metabolism R-HSA-196843 8.731336e-01 0.059 0 0
Physiological factors R-HSA-5578768 8.731336e-01 0.059 0 0
Malate-aspartate shuttle R-HSA-9856872 8.731336e-01 0.059 0 0
Regulation of KIT signaling R-HSA-1433559 8.731336e-01 0.059 0 0
Non-canonical inflammasome activation R-HSA-9686114 8.731336e-01 0.059 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.731336e-01 0.059 0 0
P2Y receptors R-HSA-417957 8.731336e-01 0.059 0 0
Zinc transporters R-HSA-435354 8.731336e-01 0.059 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 8.731973e-01 0.059 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 8.744425e-01 0.058 0 0
Signaling by MET R-HSA-6806834 8.759949e-01 0.057 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.793490e-01 0.056 0 0
Cleavage of the damaged purine R-HSA-110331 8.793490e-01 0.056 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 8.801612e-01 0.055 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.811221e-01 0.055 0 0
Metalloprotease DUBs R-HSA-5689901 8.811221e-01 0.055 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 8.811221e-01 0.055 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.811221e-01 0.055 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 8.811221e-01 0.055 0 0
Amyloid fiber formation R-HSA-977225 8.828058e-01 0.054 0 0
GPER1 signaling R-HSA-9634597 8.829295e-01 0.054 0 0
Selenoamino acid metabolism R-HSA-2408522 8.848107e-01 0.053 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.868894e-01 0.052 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.868894e-01 0.052 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.868894e-01 0.052 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.868894e-01 0.052 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.868894e-01 0.052 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 8.868894e-01 0.052 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.868894e-01 0.052 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.868894e-01 0.052 0 0
p38MAPK events R-HSA-171007 8.868894e-01 0.052 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.868894e-01 0.052 0 0
Biotin transport and metabolism R-HSA-196780 8.868894e-01 0.052 0 0
FGFR3 ligand binding and activation R-HSA-190239 8.868894e-01 0.052 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 8.868894e-01 0.052 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 8.868894e-01 0.052 0 0
Other semaphorin interactions R-HSA-416700 8.868894e-01 0.052 0 0
Processive synthesis on the lagging strand R-HSA-69183 8.868894e-01 0.052 0 0
DNA Damage Reversal R-HSA-73942 8.868894e-01 0.052 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 8.882773e-01 0.051 0 0
Regulation of mitotic cell cycle R-HSA-453276 8.882773e-01 0.051 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.882773e-01 0.051 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 8.884288e-01 0.051 0 0
Depurination R-HSA-73927 8.884288e-01 0.051 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.884288e-01 0.051 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 8.885421e-01 0.051 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 8.885421e-01 0.051 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 8.885421e-01 0.051 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 8.885421e-01 0.051 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 8.885421e-01 0.051 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.885421e-01 0.051 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 8.909126e-01 0.050 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.914135e-01 0.050 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.914135e-01 0.050 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 8.914135e-01 0.050 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 8.914135e-01 0.050 0 0
Interleukin-1 signaling R-HSA-9020702 8.934848e-01 0.049 0 0
Viral Messenger RNA Synthesis R-HSA-168325 8.955969e-01 0.048 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.955969e-01 0.048 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.968922e-01 0.047 0 0
Stabilization of p53 R-HSA-69541 8.968922e-01 0.047 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 8.969370e-01 0.047 0 0
Regulation of RAS by GAPs R-HSA-5658442 8.984146e-01 0.047 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.984146e-01 0.047 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.991545e-01 0.046 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 8.991545e-01 0.046 0 0
Killing mechanisms R-HSA-9664420 8.991545e-01 0.046 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.991545e-01 0.046 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.991545e-01 0.046 0 0
Differentiation of T cells R-HSA-9945266 8.991545e-01 0.046 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.991545e-01 0.046 0 0
Activation of SMO R-HSA-5635838 8.991545e-01 0.046 0 0
Fructose catabolism R-HSA-70350 8.991545e-01 0.046 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.991545e-01 0.046 0 0
Negative regulation of FLT3 R-HSA-9706369 8.991545e-01 0.046 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 8.991545e-01 0.046 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.008716e-01 0.045 0 0
Inflammasomes R-HSA-622312 9.008716e-01 0.045 0 0
Pyrimidine salvage R-HSA-73614 9.008716e-01 0.045 0 0
Inositol phosphate metabolism R-HSA-1483249 9.012758e-01 0.045 0 0
Signaling by PDGF R-HSA-186797 9.022620e-01 0.045 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.030222e-01 0.044 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.047732e-01 0.043 0 0
Generation of second messenger molecules R-HSA-202433 9.047732e-01 0.043 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.050489e-01 0.043 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.061811e-01 0.043 0 0
Signaling by ERBB4 R-HSA-1236394 9.071085e-01 0.042 0 0
mRNA Capping R-HSA-72086 9.095562e-01 0.041 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.095562e-01 0.041 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 9.100902e-01 0.041 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.100902e-01 0.041 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.100902e-01 0.041 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.100902e-01 0.041 0 0
Vitamin B6 activation to pyridoxal phosphate R-HSA-964975 9.100902e-01 0.041 0 0
Coenzyme A biosynthesis R-HSA-196783 9.100902e-01 0.041 0 0
Response to metal ions R-HSA-5660526 9.100902e-01 0.041 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 9.100902e-01 0.041 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.120651e-01 0.040 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 9.120651e-01 0.040 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.120651e-01 0.040 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.121050e-01 0.040 0 0
Maturation of spike protein R-HSA-9694548 9.121050e-01 0.040 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 9.121050e-01 0.040 0 0
Potential therapeutics for SARS R-HSA-9679191 9.121474e-01 0.040 0 0
MHC class II antigen presentation R-HSA-2132295 9.129084e-01 0.040 0 0
RSV-host interactions R-HSA-9833110 9.138821e-01 0.039 0 0
Ion transport by P-type ATPases R-HSA-936837 9.144876e-01 0.039 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.175236e-01 0.037 0 0
Activation of the pre-replicative complex R-HSA-68962 9.175236e-01 0.037 0 0
DAP12 signaling R-HSA-2424491 9.175236e-01 0.037 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.175236e-01 0.037 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.177427e-01 0.037 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 9.182576e-01 0.037 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.182576e-01 0.037 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.189199e-01 0.037 0 0
HIV Transcription Initiation R-HSA-167161 9.189199e-01 0.037 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.189199e-01 0.037 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.189199e-01 0.037 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.189199e-01 0.037 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.198407e-01 0.036 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 9.198407e-01 0.036 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.198407e-01 0.036 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 9.198407e-01 0.036 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 9.198407e-01 0.036 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.198407e-01 0.036 0 0
Glycogen storage diseases R-HSA-3229121 9.198407e-01 0.036 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.198407e-01 0.036 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.198407e-01 0.036 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.198407e-01 0.036 0 0
Cellular response to hypoxia R-HSA-1234174 9.200801e-01 0.036 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 9.212423e-01 0.036 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.240566e-01 0.034 0 0
Neutrophil degranulation R-HSA-6798695 9.245526e-01 0.034 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.248273e-01 0.034 0 0
Cargo concentration in the ER R-HSA-5694530 9.248273e-01 0.034 0 0
Gene Silencing by RNA R-HSA-211000 9.269109e-01 0.033 0 0
Integrin cell surface interactions R-HSA-216083 9.279060e-01 0.032 0 0
Transport of connexons to the plasma membrane R-HSA-190872 9.285342e-01 0.032 0 0
Activated point mutants of FGFR2 R-HSA-2033519 9.285342e-01 0.032 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.285342e-01 0.032 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 9.285342e-01 0.032 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.285342e-01 0.032 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.285342e-01 0.032 0 0
Tie2 Signaling R-HSA-210993 9.285342e-01 0.032 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.285342e-01 0.032 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.306709e-01 0.031 0 0
Signaling by FGFR R-HSA-190236 9.306709e-01 0.031 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.310224e-01 0.031 0 0
ER-Phagosome pathway R-HSA-1236974 9.311077e-01 0.031 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.311217e-01 0.031 0 0
Signaling by SCF-KIT R-HSA-1433557 9.311217e-01 0.031 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.315175e-01 0.031 0 0
DNA strand elongation R-HSA-69190 9.315175e-01 0.031 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.324170e-01 0.030 0 0
Signaling by FGFR1 R-HSA-5654736 9.345565e-01 0.029 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 9.345565e-01 0.029 0 0
DNA Replication Pre-Initiation R-HSA-69002 9.346207e-01 0.029 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.362854e-01 0.029 0 0
E2F mediated regulation of DNA replication R-HSA-113510 9.362854e-01 0.029 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.362854e-01 0.029 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.362854e-01 0.029 0 0
Maturation of nucleoprotein R-HSA-9694631 9.362854e-01 0.029 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.365669e-01 0.028 0 0
Surfactant metabolism R-HSA-5683826 9.365669e-01 0.028 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.376413e-01 0.028 0 0
Synthesis of PA R-HSA-1483166 9.392967e-01 0.027 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.416119e-01 0.026 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.416119e-01 0.026 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.431962e-01 0.025 0 0
Co-inhibition by CTLA4 R-HSA-389513 9.431962e-01 0.025 0 0
Glycogen synthesis R-HSA-3322077 9.431962e-01 0.025 0 0
Negative regulation of MET activity R-HSA-6807004 9.431962e-01 0.025 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.431962e-01 0.025 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.431962e-01 0.025 0 0
Pregnenolone biosynthesis R-HSA-196108 9.431962e-01 0.025 0 0
Signal transduction by L1 R-HSA-445144 9.431962e-01 0.025 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.431962e-01 0.025 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.432428e-01 0.025 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.432428e-01 0.025 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 9.434540e-01 0.025 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.437223e-01 0.025 0 0
Neuronal System R-HSA-112316 9.455072e-01 0.024 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 9.462826e-01 0.024 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.462826e-01 0.024 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.483633e-01 0.023 0 0
Signal amplification R-HSA-392518 9.483633e-01 0.023 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.483633e-01 0.023 0 0
G alpha (s) signalling events R-HSA-418555 9.487597e-01 0.023 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 9.493400e-01 0.023 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.493579e-01 0.023 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 9.493579e-01 0.023 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 9.493579e-01 0.023 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.493579e-01 0.023 0 0
G-protein activation R-HSA-202040 9.493579e-01 0.023 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.493579e-01 0.023 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.493579e-01 0.023 0 0
Signalling to RAS R-HSA-167044 9.493579e-01 0.023 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.493579e-01 0.023 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.493579e-01 0.023 0 0
Basigin interactions R-HSA-210991 9.493579e-01 0.023 0 0
Lagging Strand Synthesis R-HSA-69186 9.493579e-01 0.023 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.495539e-01 0.022 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.506037e-01 0.022 0 0
Interferon Signaling R-HSA-913531 9.507757e-01 0.022 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 9.509311e-01 0.022 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 9.509311e-01 0.022 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.530411e-01 0.021 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.530411e-01 0.021 0 0
Switching of origins to a post-replicative state R-HSA-69052 9.543223e-01 0.020 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 9.545987e-01 0.020 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.548515e-01 0.020 0 0
Attachment and Entry R-HSA-9694614 9.548515e-01 0.020 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.548515e-01 0.020 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.548515e-01 0.020 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.563003e-01 0.019 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.573121e-01 0.019 0 0
G1/S Transition R-HSA-69206 9.583773e-01 0.018 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.586262e-01 0.018 0 0
Platelet homeostasis R-HSA-418346 9.596412e-01 0.018 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.597494e-01 0.018 0 0
Fructose metabolism R-HSA-5652084 9.597494e-01 0.018 0 0
Ethanol oxidation R-HSA-71384 9.597494e-01 0.018 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.597494e-01 0.018 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 9.597494e-01 0.018 0 0
SARS-CoV-2-host interactions R-HSA-9705683 9.604626e-01 0.018 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.604713e-01 0.018 0 0
Protein ubiquitination R-HSA-8852135 9.604713e-01 0.018 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.604713e-01 0.018 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.609883e-01 0.017 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.612094e-01 0.017 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.612094e-01 0.017 0 0
NCAM1 interactions R-HSA-419037 9.612094e-01 0.017 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.626402e-01 0.017 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.641163e-01 0.016 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.641163e-01 0.016 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.641163e-01 0.016 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.641163e-01 0.016 0 0
Biosynthesis of maresins R-HSA-9018682 9.641163e-01 0.016 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.641163e-01 0.016 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.643709e-01 0.016 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.646720e-01 0.016 0 0
Elastic fibre formation R-HSA-1566948 9.647639e-01 0.016 0 0
Co-inhibition by PD-1 R-HSA-389948 9.647719e-01 0.016 0 0
The phototransduction cascade R-HSA-2514856 9.648426e-01 0.016 0 0
Selective autophagy R-HSA-9663891 9.654658e-01 0.015 0 0
Orc1 removal from chromatin R-HSA-68949 9.677429e-01 0.014 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.680039e-01 0.014 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.680096e-01 0.014 0 0
Complex III assembly R-HSA-9865881 9.680096e-01 0.014 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.680096e-01 0.014 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 9.680096e-01 0.014 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.680096e-01 0.014 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.680096e-01 0.014 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.680096e-01 0.014 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.680096e-01 0.014 0 0
Phospholipid metabolism R-HSA-1483257 9.680484e-01 0.014 0 0
PCP/CE pathway R-HSA-4086400 9.682816e-01 0.014 0 0
Downstream TCR signaling R-HSA-202424 9.699595e-01 0.013 0 0
Base Excision Repair R-HSA-73884 9.699595e-01 0.013 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.704161e-01 0.013 0 0
Vesicle-mediated transport R-HSA-5653656 9.705423e-01 0.013 0 0
Sensory processing of sound R-HSA-9659379 9.705503e-01 0.013 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.709559e-01 0.013 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 9.709559e-01 0.013 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.709559e-01 0.013 0 0
Attenuation phase R-HSA-3371568 9.709559e-01 0.013 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 9.711839e-01 0.013 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 9.714807e-01 0.013 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.714807e-01 0.013 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.714807e-01 0.013 0 0
G protein gated Potassium channels R-HSA-1296059 9.714807e-01 0.013 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 9.714807e-01 0.013 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.714807e-01 0.013 0 0
Hyaluronan degradation R-HSA-2160916 9.714807e-01 0.013 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.714807e-01 0.013 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.714807e-01 0.013 0 0
PKR-mediated signaling R-HSA-9833482 9.726678e-01 0.012 0 0
Cellular response to chemical stress R-HSA-9711123 9.730961e-01 0.012 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 9.742670e-01 0.011 0 0
Signaling by EGFR in Cancer R-HSA-1643713 9.745753e-01 0.011 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 9.745753e-01 0.011 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.745753e-01 0.011 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.754351e-01 0.011 0 0
Signaling by Insulin receptor R-HSA-74752 9.756996e-01 0.011 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.760914e-01 0.011 0 0
Translation of Structural Proteins R-HSA-9683701 9.760914e-01 0.011 0 0
Formation of the cornified envelope R-HSA-6809371 9.761924e-01 0.010 0 0
Signaling by NOTCH R-HSA-157118 9.771590e-01 0.010 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 9.772320e-01 0.010 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.772320e-01 0.010 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.772352e-01 0.010 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.773343e-01 0.010 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.773343e-01 0.010 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.773343e-01 0.010 0 0
Triglyceride biosynthesis R-HSA-75109 9.773343e-01 0.010 0 0
Synthesis of PE R-HSA-1483213 9.773343e-01 0.010 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.773343e-01 0.010 0 0
Insulin processing R-HSA-264876 9.773343e-01 0.010 0 0
Signaling by BMP R-HSA-201451 9.773343e-01 0.010 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.773343e-01 0.010 0 0
COPII-mediated vesicle transport R-HSA-204005 9.781059e-01 0.010 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.782013e-01 0.010 0 0
Activation of GABAB receptors R-HSA-991365 9.783179e-01 0.010 0 0
GABA B receptor activation R-HSA-977444 9.783179e-01 0.010 0 0
Collagen formation R-HSA-1474290 9.789430e-01 0.009 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.794123e-01 0.009 0 0
Neddylation R-HSA-8951664 9.796842e-01 0.009 0 0
HCMV Late Events R-HSA-9610379 9.797591e-01 0.009 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.798000e-01 0.009 0 0
Nucleotide Excision Repair R-HSA-5696398 9.800384e-01 0.009 0 0
Defensins R-HSA-1461973 9.803430e-01 0.009 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.803430e-01 0.009 0 0
Platelet degranulation R-HSA-114608 9.815066e-01 0.008 0 0
Thyroxine biosynthesis R-HSA-209968 9.819870e-01 0.008 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.819870e-01 0.008 0 0
Termination of translesion DNA synthesis R-HSA-5656169 9.819870e-01 0.008 0 0
Glucagon-type ligand receptors R-HSA-420092 9.819870e-01 0.008 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.819870e-01 0.008 0 0
Gap junction trafficking R-HSA-190828 9.821840e-01 0.008 0 0
DAP12 interactions R-HSA-2172127 9.821840e-01 0.008 0 0
Proteasome assembly R-HSA-9907900 9.821840e-01 0.008 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.825358e-01 0.008 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.838571e-01 0.007 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.839421e-01 0.007 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.839421e-01 0.007 0 0
GABA receptor activation R-HSA-977443 9.840245e-01 0.007 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.840245e-01 0.007 0 0
Transmission across Chemical Synapses R-HSA-112315 9.848979e-01 0.007 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.853770e-01 0.006 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.853770e-01 0.006 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.853912e-01 0.006 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.856850e-01 0.006 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.856850e-01 0.006 0 0
HCMV Early Events R-HSA-9609690 9.858215e-01 0.006 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.858809e-01 0.006 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.862199e-01 0.006 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.866453e-01 0.006 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.866453e-01 0.006 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.867573e-01 0.006 0 0
DNA Replication R-HSA-69306 9.869945e-01 0.006 0 0
HS-GAG degradation R-HSA-2024096 9.872389e-01 0.006 0 0
Translation of Structural Proteins R-HSA-9694635 9.877051e-01 0.005 0 0
G alpha (q) signalling events R-HSA-416476 9.879588e-01 0.005 0 0
Intraflagellar transport R-HSA-5620924 9.880104e-01 0.005 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.880104e-01 0.005 0 0
Recycling of bile acids and salts R-HSA-159418 9.886242e-01 0.005 0 0
Hemostasis R-HSA-109582 9.890000e-01 0.005 0 0
Gap junction trafficking and regulation R-HSA-157858 9.891475e-01 0.005 0 0
Degradation of CDH1 R-HSA-9766229 9.891475e-01 0.005 0 0
DNA Damage Bypass R-HSA-73893 9.891475e-01 0.005 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.891475e-01 0.005 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.898592e-01 0.004 0 0
Heme degradation R-HSA-189483 9.898592e-01 0.004 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.907497e-01 0.004 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.909601e-01 0.004 0 0
eNOS activation R-HSA-203615 9.909601e-01 0.004 0 0
Gap junction assembly R-HSA-190861 9.909601e-01 0.004 0 0
Hyaluronan metabolism R-HSA-2142845 9.909601e-01 0.004 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.909601e-01 0.004 0 0
RA biosynthesis pathway R-HSA-5365859 9.909601e-01 0.004 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.909601e-01 0.004 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.909601e-01 0.004 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.909749e-01 0.004 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.911147e-01 0.004 0 0
Nicotinate metabolism R-HSA-196807 9.915137e-01 0.004 0 0
Metabolism of steroid hormones R-HSA-196071 9.915137e-01 0.004 0 0
Adaptive Immune System R-HSA-1280218 9.915335e-01 0.004 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.919416e-01 0.004 0 0
PERK regulates gene expression R-HSA-381042 9.919416e-01 0.004 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.919416e-01 0.004 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.919416e-01 0.004 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.919416e-01 0.004 0 0
HCMV Infection R-HSA-9609646 9.919502e-01 0.004 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.919630e-01 0.004 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.919630e-01 0.004 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.922562e-01 0.003 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.927319e-01 0.003 0 0
HS-GAG biosynthesis R-HSA-2022928 9.928166e-01 0.003 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.928166e-01 0.003 0 0
HSF1 activation R-HSA-3371511 9.928166e-01 0.003 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.928166e-01 0.003 0 0
Synthesis of DNA R-HSA-69239 9.931165e-01 0.003 0 0
Leishmania phagocytosis R-HSA-9664417 9.931374e-01 0.003 0 0
Parasite infection R-HSA-9664407 9.931374e-01 0.003 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.931374e-01 0.003 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.934287e-01 0.003 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.935966e-01 0.003 0 0
Degradation of DVL R-HSA-4641258 9.935966e-01 0.003 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.935966e-01 0.003 0 0
Collagen chain trimerization R-HSA-8948216 9.935966e-01 0.003 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.940599e-01 0.003 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.940599e-01 0.003 0 0
G alpha (z) signalling events R-HSA-418597 9.940599e-01 0.003 0 0
Retinoid metabolism and transport R-HSA-975634 9.941258e-01 0.003 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.942810e-01 0.002 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.942920e-01 0.002 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.945132e-01 0.002 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 9.946315e-01 0.002 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.947549e-01 0.002 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.949119e-01 0.002 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.949119e-01 0.002 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.949119e-01 0.002 0 0
RAS processing R-HSA-9648002 9.949119e-01 0.002 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.949119e-01 0.002 0 0
Parasitic Infection Pathways R-HSA-9824443 9.949432e-01 0.002 0 0
Leishmania infection R-HSA-9658195 9.949432e-01 0.002 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.951019e-01 0.002 0 0
Regulation of CDH1 Function R-HSA-9764561 9.951491e-01 0.002 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.951909e-01 0.002 0 0
Interleukin-2 family signaling R-HSA-451927 9.954645e-01 0.002 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.954645e-01 0.002 0 0
Tryptophan catabolism R-HSA-71240 9.954645e-01 0.002 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.954753e-01 0.002 0 0
Signaling by NOTCH4 R-HSA-9013694 9.955544e-01 0.002 0 0
Dual incision in TC-NER R-HSA-6782135 9.956176e-01 0.002 0 0
GPCR downstream signalling R-HSA-388396 9.958520e-01 0.002 0 0
Iron uptake and transport R-HSA-917937 9.959507e-01 0.002 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.959571e-01 0.002 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.959571e-01 0.002 0 0
Peroxisomal protein import R-HSA-9033241 9.960416e-01 0.002 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 9.962208e-01 0.002 0 0
UCH proteinases R-HSA-5689603 9.963126e-01 0.002 0 0
RAB geranylgeranylation R-HSA-8873719 9.964252e-01 0.002 0 0
Glutathione conjugation R-HSA-156590 9.964252e-01 0.002 0 0
Nucleotide salvage R-HSA-8956321 9.967722e-01 0.001 0 0
Collagen degradation R-HSA-1442490 9.967722e-01 0.001 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.967877e-01 0.001 0 0
Interferon alpha/beta signaling R-HSA-909733 9.968539e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.969443e-01 0.001 0 0
Cholesterol biosynthesis R-HSA-191273 9.969443e-01 0.001 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.971367e-01 0.001 0 0
Pyrimidine catabolism R-HSA-73621 9.971367e-01 0.001 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.971367e-01 0.001 0 0
Protein folding R-HSA-391251 9.971584e-01 0.001 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.974477e-01 0.001 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.974477e-01 0.001 0 0
Mitochondrial protein degradation R-HSA-9837999 9.976202e-01 0.001 0 0
SLC transporter disorders R-HSA-5619102 9.976617e-01 0.001 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.976728e-01 0.001 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.976988e-01 0.001 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.977250e-01 0.001 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.977250e-01 0.001 0 0
Somitogenesis R-HSA-9824272 9.977250e-01 0.001 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.977250e-01 0.001 0 0
SARS-CoV Infections R-HSA-9679506 9.977624e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.979610e-01 0.001 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.979722e-01 0.001 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.980677e-01 0.001 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.981925e-01 0.001 0 0
Synthesis of PC R-HSA-1483191 9.981925e-01 0.001 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.982570e-01 0.001 0 0
Gluconeogenesis R-HSA-70263 9.983889e-01 0.001 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 9.984280e-01 0.001 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.985640e-01 0.001 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.986099e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.987218e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.988110e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.988477e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.988477e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.988477e-01 0.001 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.988592e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.988592e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.989613e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.990277e-01 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 9.990937e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.991564e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.991942e-01 0.000 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.992399e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.993583e-01 0.000 0 0
Digestion R-HSA-8935690 9.993583e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.994143e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.994281e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.994443e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.995361e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.995457e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.995457e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.996391e-01 0.000 0 0
Protein localization R-HSA-9609507 9.996782e-01 0.000 0 0
Mitochondrial protein import R-HSA-1268020 9.996784e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.997133e-01 0.000 0 0
ABC-family proteins mediated transport R-HSA-382556 9.997270e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.997419e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.997445e-01 0.000 0 0
tRNA processing R-HSA-72306 9.997656e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.997723e-01 0.000 0 0
Viral Infection Pathways R-HSA-9824446 9.997749e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.997988e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.997998e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.998192e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.998254e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.998354e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.998388e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.998449e-01 0.000 0 0
Neurotransmitter release cycle R-HSA-112310 9.998587e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.998587e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.998859e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.998959e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999020e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999094e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999173e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.999252e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999280e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999453e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999453e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999491e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999546e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999548e-01 0.000 0 0
Immune System R-HSA-168256 9.999618e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999635e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999640e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999745e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999820e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999828e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999839e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999899e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999928e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999951e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999952e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999958e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999965e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999970e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999976e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999983e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999989e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999993e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999998e-01 0.000 0 0
Translation R-HSA-72766 9.999999e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999999e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999999e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cellular responses to stimuli R-HSA-8953897 5.995204e-14 13.222 0 0
Metabolism of RNA R-HSA-8953854 1.415534e-13 12.849 0 0
M Phase R-HSA-68886 2.322587e-13 12.634 0 0
Cellular responses to stress R-HSA-2262752 3.008704e-13 12.522 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.980194e-12 11.703 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.911582e-12 11.719 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.911582e-12 11.719 0 0
Signaling by ROBO receptors R-HSA-376176 1.396327e-12 11.855 0 0
Cell Cycle R-HSA-1640170 1.978084e-12 11.704 0 0
Axon guidance R-HSA-422475 2.634892e-12 11.579 0 0
Cell Cycle, Mitotic R-HSA-69278 5.410339e-12 11.267 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 7.359446e-12 11.133 0 0
Cellular Senescence R-HSA-2559583 1.269262e-11 10.896 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.523115e-11 10.817 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.506462e-11 10.822 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.715605e-11 10.766 0 0
Nervous system development R-HSA-9675108 2.728628e-11 10.564 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 3.329825e-11 10.478 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 4.555711e-11 10.341 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.802636e-11 10.319 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 5.796852e-11 10.237 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.087054e-10 9.964 0 0
Mitotic Prophase R-HSA-68875 2.028557e-10 9.693 0 0
Cell-Cell communication R-HSA-1500931 2.150781e-10 9.667 0 0
Cell Cycle Checkpoints R-HSA-69620 2.354590e-10 9.628 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 4.188040e-10 9.378 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 5.129958e-10 9.290 0 0
Cell junction organization R-HSA-446728 6.251965e-10 9.204 0 0
Peptide chain elongation R-HSA-156902 6.781132e-10 9.169 0 0
G2/M Checkpoints R-HSA-69481 1.091234e-09 8.962 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.184963e-09 8.926 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.149216e-09 8.940 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.389406e-09 8.857 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.519603e-09 8.818 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.740661e-09 8.759 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.630257e-09 8.580 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.630257e-09 8.580 0 0
Apoptotic execution phase R-HSA-75153 2.661378e-09 8.575 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.971577e-09 8.527 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.971577e-09 8.527 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 3.994882e-09 8.398 0 0
HATs acetylate histones R-HSA-3214847 4.372406e-09 8.359 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 4.737448e-09 8.324 0 0
PRC2 methylates histones and DNA R-HSA-212300 5.225962e-09 8.282 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 5.751376e-09 8.240 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 9.157618e-09 8.038 0 0
G2/M DNA damage checkpoint R-HSA-69473 9.762616e-09 8.010 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.016078e-08 7.993 0 0
Ribosome-associated quality control R-HSA-9948299 1.272454e-08 7.895 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.229834e-08 7.910 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.279113e-08 7.893 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.411940e-08 7.850 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.411940e-08 7.850 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.419326e-08 7.848 0 0
Apoptosis R-HSA-109581 1.485850e-08 7.828 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.734263e-08 7.761 0 0
Eukaryotic Translation Termination R-HSA-72764 1.978400e-08 7.704 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.149381e-08 7.668 0 0
Chromatin modifying enzymes R-HSA-3247509 2.614469e-08 7.583 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 2.947700e-08 7.531 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.852625e-08 7.545 0 0
DNA methylation R-HSA-5334118 2.950177e-08 7.530 0 0
Chromatin organization R-HSA-4839726 3.254587e-08 7.488 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 3.461568e-08 7.461 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.649538e-08 7.438 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 3.797366e-08 7.421 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.334008e-08 7.363 0 0
HDACs deacetylate histones R-HSA-3214815 4.658679e-08 7.332 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 4.839179e-08 7.315 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 5.138525e-08 7.289 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.818854e-08 7.235 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 6.382380e-08 7.195 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 6.439569e-08 7.191 0 0
Cellular response to heat stress R-HSA-3371556 6.910472e-08 7.160 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 8.474154e-08 7.072 0 0
Influenza Infection R-HSA-168255 8.867009e-08 7.052 0 0
RNA Polymerase I Transcription R-HSA-73864 9.331204e-08 7.030 0 0
Defective pyroptosis R-HSA-9710421 8.966187e-08 7.047 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.558011e-07 6.807 0 0
Selenocysteine synthesis R-HSA-2408557 2.120353e-07 6.674 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 2.256431e-07 6.647 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.294921e-07 6.639 0 0
Programmed Cell Death R-HSA-5357801 2.438830e-07 6.613 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.566436e-07 6.591 0 0
DNA Double Strand Break Response R-HSA-5693606 2.909295e-07 6.536 0 0
Viral mRNA Translation R-HSA-192823 3.098624e-07 6.509 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 3.124366e-07 6.505 0 0
Packaging Of Telomere Ends R-HSA-171306 3.663550e-07 6.436 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.691811e-07 6.433 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 4.728743e-07 6.325 0 0
Adherens junctions interactions R-HSA-418990 5.329643e-07 6.273 0 0
rRNA processing R-HSA-72312 5.583445e-07 6.253 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 5.869140e-07 6.231 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 6.318008e-07 6.199 0 0
Interleukin-12 signaling R-HSA-9020591 6.684369e-07 6.175 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 6.842211e-07 6.165 0 0
Nucleosome assembly R-HSA-774815 6.842211e-07 6.165 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 7.934177e-07 6.100 0 0
Signaling by RAF1 mutants R-HSA-9656223 8.683515e-07 6.061 0 0
Signaling downstream of RAS mutants R-HSA-9649948 9.068280e-07 6.042 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 9.068280e-07 6.042 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 9.068280e-07 6.042 0 0
Signaling by RAS mutants R-HSA-6802949 9.068280e-07 6.042 0 0
Meiotic recombination R-HSA-912446 9.129394e-07 6.040 0 0
Diseases of programmed cell death R-HSA-9645723 9.734495e-07 6.012 0 0
Cell-cell junction organization R-HSA-421270 9.997735e-07 6.000 0 0
DNA Replication R-HSA-69306 1.115362e-06 5.953 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.141188e-06 5.943 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.189884e-06 5.924 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.460088e-06 5.836 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.560937e-06 5.807 0 0
Meiotic synapsis R-HSA-1221632 1.528646e-06 5.816 0 0
Signaling by WNT R-HSA-195721 1.580733e-06 5.801 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.635066e-06 5.786 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.888602e-06 5.724 0 0
Translation initiation complex formation R-HSA-72649 1.961269e-06 5.707 0 0
Gene Silencing by RNA R-HSA-211000 2.141373e-06 5.669 0 0
Cellular response to starvation R-HSA-9711097 2.210179e-06 5.656 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 2.218192e-06 5.654 0 0
Homology Directed Repair R-HSA-5693538 2.419505e-06 5.616 0 0
Interleukin-12 family signaling R-HSA-447115 2.418365e-06 5.616 0 0
Signal Transduction R-HSA-162582 2.564024e-06 5.591 1 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 2.632434e-06 5.580 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.632434e-06 5.580 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 2.969613e-06 5.527 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 3.176772e-06 5.498 0 0
mRNA Splicing - Major Pathway R-HSA-72163 3.459793e-06 5.461 0 0
MAP2K and MAPK activation R-HSA-5674135 3.481322e-06 5.458 0 0
Meiosis R-HSA-1500620 4.085584e-06 5.389 0 0
Cell-extracellular matrix interactions R-HSA-446353 4.649772e-06 5.333 0 0
SARS-CoV-1-host interactions R-HSA-9692914 4.938886e-06 5.306 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 5.692042e-06 5.245 0 0
DNA Double-Strand Break Repair R-HSA-5693532 6.443984e-06 5.191 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 6.557376e-06 5.183 0 0
Co-inhibition by PD-1 R-HSA-389948 6.875521e-06 5.163 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 7.599133e-06 5.119 0 0
Estrogen-dependent gene expression R-HSA-9018519 8.076865e-06 5.093 0 0
SARS-CoV-2-host interactions R-HSA-9705683 7.649305e-06 5.116 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 9.253128e-06 5.034 0 0
Mitotic Anaphase R-HSA-68882 9.547677e-06 5.020 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 9.653195e-06 5.015 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.060291e-05 4.975 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.122696e-05 4.950 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.186122e-05 4.926 0 0
mRNA Splicing R-HSA-72172 1.187654e-05 4.925 0 0
Signaling by NOTCH R-HSA-157118 1.250459e-05 4.903 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.396697e-05 4.855 0 0
Cleavage of the damaged purine R-HSA-110331 1.340871e-05 4.873 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.519374e-05 4.818 0 0
Signaling by ALK in cancer R-HSA-9700206 1.519374e-05 4.818 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.579972e-05 4.801 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.635723e-05 4.786 0 0
Amyloid fiber formation R-HSA-977225 1.670055e-05 4.777 0 0
Depurination R-HSA-73927 1.754090e-05 4.756 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.855586e-05 4.544 0 0
Host Interactions of HIV factors R-HSA-162909 3.599252e-05 4.444 0 0
Regulation of CDH1 Function R-HSA-9764561 4.293811e-05 4.367 0 0
Nuclear Envelope Breakdown R-HSA-2980766 4.293811e-05 4.367 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.876314e-05 4.312 0 0
mRNA 3'-end processing R-HSA-72187 4.876314e-05 4.312 0 0
Translation R-HSA-72766 4.529601e-05 4.344 0 0
Telomere Maintenance R-HSA-157579 4.965989e-05 4.304 0 0
Selenoamino acid metabolism R-HSA-2408522 5.358310e-05 4.271 0 0
Chromosome Maintenance R-HSA-73886 5.759420e-05 4.240 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 5.971405e-05 4.224 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 6.011478e-05 4.221 0 0
Depyrimidination R-HSA-73928 6.011478e-05 4.221 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 8.218082e-05 4.085 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.036689e-04 3.984 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.246013e-04 3.904 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.396893e-04 3.855 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.318395e-04 3.880 0 0
ESR-mediated signaling R-HSA-8939211 1.397756e-04 3.855 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.433338e-04 3.844 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.934055e-04 3.714 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.984909e-04 3.702 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.458087e-04 3.609 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 2.483417e-04 3.605 0 0
Negative regulation of MET activity R-HSA-6807004 2.546380e-04 3.594 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.658601e-04 3.575 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 3.099009e-04 3.509 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 3.122488e-04 3.505 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.444657e-04 3.463 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 3.618349e-04 3.441 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.758720e-04 3.425 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 3.795988e-04 3.421 0 0
HIV Infection R-HSA-162906 3.969702e-04 3.401 0 0
PKMTs methylate histone lysines R-HSA-3214841 4.228954e-04 3.374 0 0
Signaling by Hippo R-HSA-2028269 4.351367e-04 3.361 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 4.613904e-04 3.336 0 0
Epigenetic regulation of gene expression R-HSA-212165 4.878241e-04 3.312 0 0
Mitotic Prometaphase R-HSA-68877 4.935623e-04 3.307 0 0
Developmental Biology R-HSA-1266738 4.750585e-04 3.323 0 0
Reproduction R-HSA-1474165 4.675719e-04 3.330 0 0
Base Excision Repair R-HSA-73884 5.245643e-04 3.280 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 5.747146e-04 3.241 0 0
Viral Infection Pathways R-HSA-9824446 5.773910e-04 3.239 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 5.939215e-04 3.226 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 6.345404e-04 3.198 0 0
HCMV Early Events R-HSA-9609690 6.367252e-04 3.196 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 7.276689e-04 3.138 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 7.277132e-04 3.138 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 7.420728e-04 3.130 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 7.420728e-04 3.130 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 7.420728e-04 3.130 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 7.516408e-04 3.124 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 7.516408e-04 3.124 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 7.608455e-04 3.119 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 7.608455e-04 3.119 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 8.332461e-04 3.079 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 8.727886e-04 3.059 0 0
Protein ubiquitination R-HSA-8852135 8.656114e-04 3.063 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 8.727886e-04 3.059 0 0
Separation of Sister Chromatids R-HSA-2467813 9.250811e-04 3.034 0 0
HCMV Late Events R-HSA-9610379 9.585834e-04 3.018 0 0
G2/M Transition R-HSA-69275 9.703010e-04 3.013 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 9.832415e-04 3.007 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 9.832415e-04 3.007 0 0
Semaphorin interactions R-HSA-373755 9.832415e-04 3.007 0 0
UCH proteinases R-HSA-5689603 9.924620e-04 3.003 0 0
Deubiquitination R-HSA-5688426 1.023757e-03 2.990 0 0
Nuclear import of Rev protein R-HSA-180746 1.025748e-03 2.989 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.031487e-03 2.987 0 0
HSF1-dependent transactivation R-HSA-3371571 1.066675e-03 2.972 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.071973e-03 2.970 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.143028e-03 2.942 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.167138e-03 2.933 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.221205e-03 2.913 0 0
MAPK family signaling cascades R-HSA-5683057 1.326439e-03 2.877 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.361534e-03 2.866 0 0
Metabolism of non-coding RNA R-HSA-194441 1.399369e-03 2.854 0 0
snRNP Assembly R-HSA-191859 1.399369e-03 2.854 0 0
EGFR downregulation R-HSA-182971 1.445067e-03 2.840 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.445067e-03 2.840 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.445067e-03 2.840 0 0
Smooth Muscle Contraction R-HSA-445355 1.470201e-03 2.833 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.515893e-03 2.819 0 0
HSF1 activation R-HSA-3371511 1.522354e-03 2.817 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.522354e-03 2.817 0 0
FLT3 signaling in disease R-HSA-9682385 1.522354e-03 2.817 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.542835e-03 2.812 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.542835e-03 2.812 0 0
Metalloprotease DUBs R-HSA-5689901 1.630775e-03 2.788 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.605772e-03 2.794 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.783398e-03 2.749 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.783398e-03 2.749 0 0
HIV Life Cycle R-HSA-162587 1.839511e-03 2.735 0 0
Signaling by NOTCH3 R-HSA-9012852 1.994417e-03 2.700 0 0
Centrosome maturation R-HSA-380287 2.079202e-03 2.682 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 2.115079e-03 2.675 0 0
Josephin domain DUBs R-HSA-5689877 2.122638e-03 2.673 0 0
Ub-specific processing proteases R-HSA-5689880 2.142015e-03 2.669 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.163911e-03 2.665 0 0
Glycolysis R-HSA-70171 2.172723e-03 2.663 0 0
Gene expression (Transcription) R-HSA-74160 2.219567e-03 2.654 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.247125e-03 2.648 0 0
mTORC1-mediated signalling R-HSA-166208 2.269697e-03 2.644 0 0
Signaling by EGFR R-HSA-177929 2.309858e-03 2.636 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 2.471270e-03 2.607 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.619241e-03 2.582 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.625004e-03 2.581 0 0
Membrane Trafficking R-HSA-199991 2.672700e-03 2.573 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.707658e-03 2.567 0 0
DNA Repair R-HSA-73894 2.758643e-03 2.559 0 0
S Phase R-HSA-69242 3.060755e-03 2.514 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.078584e-03 2.512 0 0
Attenuation phase R-HSA-3371568 3.111667e-03 2.507 0 0
Rap1 signalling R-HSA-392517 3.138996e-03 2.503 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 3.245254e-03 2.489 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 3.245254e-03 2.489 0 0
Spry regulation of FGF signaling R-HSA-1295596 3.261371e-03 2.487 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 3.261371e-03 2.487 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.324868e-03 2.478 0 0
Regulation of PTEN localization R-HSA-8948747 3.511598e-03 2.454 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 3.555706e-03 2.449 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 3.633648e-03 2.440 0 0
Activation of HOX genes during differentiation R-HSA-5619507 3.633648e-03 2.440 0 0
SARS-CoV-2 Infection R-HSA-9694516 3.720749e-03 2.429 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.761385e-03 2.425 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 4.303718e-03 2.366 0 0
EPH-Ephrin signaling R-HSA-2682334 3.768310e-03 2.424 0 0
Prolonged ERK activation events R-HSA-169893 4.294990e-03 2.367 0 0
CaM pathway R-HSA-111997 4.465425e-03 2.350 0 0
Calmodulin induced events R-HSA-111933 4.465425e-03 2.350 0 0
Signaling by NOTCH4 R-HSA-9013694 4.227679e-03 2.374 0 0
Signaling by MET R-HSA-6806834 3.796559e-03 2.421 0 0
Activation of BH3-only proteins R-HSA-114452 3.741459e-03 2.427 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 4.512560e-03 2.346 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.711823e-03 2.327 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 4.874892e-03 2.312 0 0
Ca-dependent events R-HSA-111996 5.023669e-03 2.299 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.187850e-03 2.285 0 0
Formation of annular gap junctions R-HSA-196025 5.219820e-03 2.282 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 5.219820e-03 2.282 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 5.219820e-03 2.282 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 5.219820e-03 2.282 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 5.222693e-03 2.282 0 0
RAF/MAP kinase cascade R-HSA-5673001 5.224897e-03 2.282 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 5.270280e-03 2.278 0 0
Platelet activation, signaling and aggregation R-HSA-76002 5.672663e-03 2.246 0 0
VLDLR internalisation and degradation R-HSA-8866427 5.764380e-03 2.239 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.871661e-03 2.231 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 6.244478e-03 2.205 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 6.426387e-03 2.192 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 6.431100e-03 2.192 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.548726e-03 2.184 0 0
G alpha (12/13) signalling events R-HSA-416482 6.638542e-03 2.178 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 6.750125e-03 2.171 0 0
RMTs methylate histone arginines R-HSA-3214858 6.750125e-03 2.171 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 6.750125e-03 2.171 0 0
Uptake and function of anthrax toxins R-HSA-5210891 7.082210e-03 2.150 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 7.221079e-03 2.141 0 0
Gap junction degradation R-HSA-190873 7.445339e-03 2.128 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 7.593593e-03 2.120 0 0
Frs2-mediated activation R-HSA-170968 7.641169e-03 2.117 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 7.772912e-03 2.109 0 0
DAG and IP3 signaling R-HSA-1489509 7.772912e-03 2.109 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 9.922419e-03 2.003 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 8.894829e-03 2.051 0 0
Ephrin signaling R-HSA-3928664 8.894829e-03 2.051 0 0
RAF activation R-HSA-5673000 8.917835e-03 2.050 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 8.913294e-03 2.050 0 0
Orc1 removal from chromatin R-HSA-68949 8.122999e-03 2.090 0 0
Synthesis of DNA R-HSA-69239 9.484572e-03 2.023 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.693908e-03 2.014 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 8.789506e-03 2.056 0 0
Switching of origins to a post-replicative state R-HSA-69052 8.325834e-03 2.080 0 0
G-protein mediated events R-HSA-112040 9.366353e-03 2.028 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 8.793207e-03 2.056 0 0
Mitotic Spindle Checkpoint R-HSA-69618 9.070708e-03 2.042 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 8.205778e-03 2.086 0 0
HCMV Infection R-HSA-9609646 9.386782e-03 2.027 0 0
RNA Polymerase II Transcription R-HSA-73857 9.411173e-03 2.026 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.917835e-03 2.050 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 9.046134e-03 2.044 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 8.894829e-03 2.051 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 8.913294e-03 2.050 0 0
Intracellular signaling by second messengers R-HSA-9006925 9.302771e-03 2.031 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 8.282678e-03 2.082 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 8.325834e-03 2.080 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 9.693908e-03 2.014 0 0
Maturation of protein E R-HSA-9683683 8.789506e-03 2.056 0 0
Maturation of protein E R-HSA-9694493 8.789506e-03 2.056 0 0
Recycling pathway of L1 R-HSA-437239 1.017991e-02 1.992 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 1.017991e-02 1.992 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 1.025845e-02 1.989 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.025845e-02 1.989 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.025845e-02 1.989 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.025845e-02 1.989 0 0
Regulation of Apoptosis R-HSA-169911 1.041202e-02 1.982 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.043636e-02 1.981 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.043636e-02 1.981 0 0
PLC beta mediated events R-HSA-112043 1.051450e-02 1.978 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.098112e-02 1.959 0 0
Regulation of signaling by CBL R-HSA-912631 1.102617e-02 1.958 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.102617e-02 1.958 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 1.115209e-02 1.953 0 0
Signaling by Interleukins R-HSA-449147 1.136406e-02 1.944 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.147974e-02 1.940 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.157340e-02 1.937 0 0
SARS-CoV Infections R-HSA-9679506 1.177396e-02 1.929 0 0
tRNA processing in the nucleus R-HSA-6784531 1.177583e-02 1.929 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.208915e-02 1.918 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.265041e-02 1.898 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.265041e-02 1.898 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.265041e-02 1.898 0 0
p75NTR signals via NF-kB R-HSA-193639 1.265041e-02 1.898 0 0
MTOR signalling R-HSA-165159 1.277224e-02 1.894 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.277224e-02 1.894 0 0
Opioid Signalling R-HSA-111885 1.284734e-02 1.891 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.284734e-02 1.891 0 0
Nef and signal transduction R-HSA-164944 1.303903e-02 1.885 0 0
Degradation of CDH1 R-HSA-9766229 1.312699e-02 1.882 0 0
Regulation of TP53 Activity R-HSA-5633007 1.327762e-02 1.877 0 0
Glucose metabolism R-HSA-70326 1.355206e-02 1.868 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.372442e-02 1.863 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.372442e-02 1.863 0 0
PCP/CE pathway R-HSA-4086400 1.391865e-02 1.856 0 0
Degradation of DVL R-HSA-4641258 1.396228e-02 1.855 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.474549e-02 1.831 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.474549e-02 1.831 0 0
Nucleotide Excision Repair R-HSA-5696398 1.515461e-02 1.819 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.586531e-02 1.800 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.586531e-02 1.800 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 1.586531e-02 1.800 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.595127e-02 1.797 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.595127e-02 1.797 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.635997e-02 1.786 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.635997e-02 1.786 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.635997e-02 1.786 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.722521e-02 1.764 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.722521e-02 1.764 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.722521e-02 1.764 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.722521e-02 1.764 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.722521e-02 1.764 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.722521e-02 1.764 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.841093e-02 1.735 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.841093e-02 1.735 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.961722e-02 1.707 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.748942e-02 1.757 0 0
Striated Muscle Contraction R-HSA-390522 2.018071e-02 1.695 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 1.834821e-02 1.736 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 1.871536e-02 1.728 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 2.092488e-02 1.679 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.092488e-02 1.679 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.960455e-02 1.708 0 0
NF-kB is activated and signals survival R-HSA-209560 1.790205e-02 1.747 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.790205e-02 1.747 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.191150e-02 1.659 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 2.120351e-02 1.674 0 0
Stabilization of p53 R-HSA-69541 1.834821e-02 1.736 0 0
Kinesins R-HSA-983189 2.051493e-02 1.688 0 0
Cilium Assembly R-HSA-5617833 1.988699e-02 1.701 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.790205e-02 1.747 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 2.088638e-02 1.680 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.834821e-02 1.736 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.868904e-02 1.728 0 0
Vpu mediated degradation of CD4 R-HSA-180534 2.018071e-02 1.695 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 2.256666e-02 1.647 0 0
Disorders of Nervous System Development R-HSA-9697154 2.284255e-02 1.641 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.284255e-02 1.641 0 0
Pervasive developmental disorders R-HSA-9005895 2.284255e-02 1.641 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.284255e-02 1.641 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.284255e-02 1.641 0 0
Dual Incision in GG-NER R-HSA-5696400 2.315856e-02 1.635 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.315856e-02 1.635 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 2.315856e-02 1.635 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.330206e-02 1.633 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 2.367106e-02 1.626 0 0
FLT3 Signaling R-HSA-9607240 2.367106e-02 1.626 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.379178e-02 1.624 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.390219e-02 1.622 0 0
Organelle biogenesis and maintenance R-HSA-1852241 2.394360e-02 1.621 0 0
Type I hemidesmosome assembly R-HSA-446107 2.497922e-02 1.602 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 2.497922e-02 1.602 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 2.497922e-02 1.602 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 2.497922e-02 1.602 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.497922e-02 1.602 0 0
Modulation by Mtb of host immune system R-HSA-9637628 2.497922e-02 1.602 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 2.512076e-02 1.600 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 2.541593e-02 1.595 0 0
Late endosomal microautophagy R-HSA-9615710 2.541593e-02 1.595 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 2.541593e-02 1.595 0 0
Termination of translesion DNA synthesis R-HSA-5656169 2.541593e-02 1.595 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.541593e-02 1.595 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 2.591570e-02 1.586 0 0
Signaling by VEGF R-HSA-194138 2.599274e-02 1.585 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 2.643743e-02 1.578 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 2.643743e-02 1.578 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.654146e-02 1.576 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.654146e-02 1.576 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.743767e-02 1.562 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 2.858871e-02 1.544 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 2.858871e-02 1.544 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 2.871355e-02 1.542 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 2.871355e-02 1.542 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.878848e-02 1.541 0 0
DNA Damage Bypass R-HSA-73893 2.953090e-02 1.530 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.953090e-02 1.530 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.002652e-02 1.522 0 0
RET signaling R-HSA-8853659 3.003101e-02 1.522 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 3.003101e-02 1.522 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.176629e-02 1.498 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 3.184149e-02 1.497 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.204502e-02 1.494 0 0
ARMS-mediated activation R-HSA-170984 3.279437e-02 1.484 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.279437e-02 1.484 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 3.279437e-02 1.484 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 3.279437e-02 1.484 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.279437e-02 1.484 0 0
Regulation of RAS by GAPs R-HSA-5658442 3.281936e-02 1.484 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 3.335551e-02 1.477 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 3.355978e-02 1.474 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 3.361918e-02 1.473 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.395208e-02 1.469 0 0
Degradation of AXIN R-HSA-4641257 3.395208e-02 1.469 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 3.395208e-02 1.469 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 3.428942e-02 1.465 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.450788e-02 1.462 0 0
Clathrin-mediated endocytosis R-HSA-8856828 3.502300e-02 1.456 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 3.517439e-02 1.454 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 3.517439e-02 1.454 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 3.517439e-02 1.454 0 0
NRIF signals cell death from the nucleus R-HSA-205043 3.517439e-02 1.454 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.633161e-02 1.440 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 3.714263e-02 1.430 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 3.714263e-02 1.430 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.714263e-02 1.430 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.822951e-02 1.418 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 4.015803e-02 1.396 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 4.015803e-02 1.396 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 4.042648e-02 1.393 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 4.042648e-02 1.393 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 4.042648e-02 1.393 0 0
Nephrin family interactions R-HSA-373753 4.042648e-02 1.393 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.042648e-02 1.393 0 0
Protein hydroxylation R-HSA-9629569 4.042648e-02 1.393 0 0
Developmental Cell Lineages R-HSA-9734767 4.073958e-02 1.390 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 6.058206e-02 1.218 0 0
Regulation of TP53 Expression R-HSA-6804754 6.058206e-02 1.218 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 6.058206e-02 1.218 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 6.058206e-02 1.218 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 6.058206e-02 1.218 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 6.058206e-02 1.218 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 6.058206e-02 1.218 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 6.058206e-02 1.218 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 6.058206e-02 1.218 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 6.058206e-02 1.218 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 6.058206e-02 1.218 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 6.058206e-02 1.218 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 6.058206e-02 1.218 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 6.058206e-02 1.218 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 4.636389e-02 1.334 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 4.636389e-02 1.334 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.188418e-02 1.378 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 4.262425e-02 1.370 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 4.262425e-02 1.370 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 4.262425e-02 1.370 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 5.095370e-02 1.293 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 6.016907e-02 1.221 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 5.467105e-02 1.262 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 5.467105e-02 1.262 0 0
Interaction between L1 and Ankyrins R-HSA-445095 4.886938e-02 1.311 0 0
Integrin signaling R-HSA-354192 4.331530e-02 1.363 0 0
Aggrephagy R-HSA-9646399 4.779231e-02 1.321 0 0
Signaling by EGFR in Cancer R-HSA-1643713 4.274639e-02 1.369 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 4.520031e-02 1.345 0 0
Chaperonin-mediated protein folding R-HSA-390466 6.004692e-02 1.222 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 4.372495e-02 1.359 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 4.372495e-02 1.359 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 4.721641e-02 1.326 0 0
Post NMDA receptor activation events R-HSA-438064 6.004692e-02 1.222 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 6.116902e-02 1.213 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 5.312957e-02 1.275 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 4.372495e-02 1.359 0 0
Disorders of Developmental Biology R-HSA-9675151 6.016907e-02 1.221 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 4.094917e-02 1.388 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 5.312957e-02 1.275 0 0
Hedgehog 'off' state R-HSA-5610787 5.534327e-02 1.257 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.550233e-02 1.256 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.550233e-02 1.256 0 0
Signaling by FGFR1 in disease R-HSA-5655302 5.884132e-02 1.230 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 4.636389e-02 1.334 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.886938e-02 1.311 0 0
Degradation of CRY and PER proteins R-HSA-9932298 5.884132e-02 1.230 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.165331e-02 1.380 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 5.477695e-02 1.261 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 4.570258e-02 1.340 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 6.116902e-02 1.213 0 0
Signalling to ERKs R-HSA-187687 6.116902e-02 1.213 0 0
Generic Transcription Pathway R-HSA-212436 6.026570e-02 1.220 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 4.331530e-02 1.363 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 4.168401e-02 1.380 0 0
Signaling by NOTCH2 R-HSA-1980145 5.477695e-02 1.261 0 0
Signaling by NOTCH1 R-HSA-1980143 4.439033e-02 1.353 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 4.168401e-02 1.380 0 0
G1/S Transition R-HSA-69206 4.372495e-02 1.359 0 0
Signaling by Nuclear Receptors R-HSA-9006931 4.588043e-02 1.338 0 0
Hedgehog 'on' state R-HSA-5632684 5.550233e-02 1.256 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 4.168401e-02 1.380 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 4.274639e-02 1.369 0 0
Regulation of PTEN gene transcription R-HSA-8943724 4.210030e-02 1.376 0 0
Signaling by ERBB2 R-HSA-1227986 4.210030e-02 1.376 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 5.225516e-02 1.282 0 0
Muscle contraction R-HSA-397014 4.231152e-02 1.374 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 4.779231e-02 1.321 0 0
Cytokine Signaling in Immune system R-HSA-1280215 4.813320e-02 1.318 0 0
Signaling by PTK6 R-HSA-8848021 5.463279e-02 1.263 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.463279e-02 1.263 0 0
Negative regulation of FLT3 R-HSA-9706369 5.095370e-02 1.293 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 5.312957e-02 1.275 0 0
Pexophagy R-HSA-9664873 4.188418e-02 1.378 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 5.808637e-02 1.236 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 6.149685e-02 1.211 0 0
DARPP-32 events R-HSA-180024 6.271081e-02 1.203 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 6.279739e-02 1.202 0 0
Death Receptor Signaling R-HSA-73887 6.378293e-02 1.195 0 0
L1CAM interactions R-HSA-373760 6.456545e-02 1.190 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 6.493303e-02 1.188 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 6.493303e-02 1.188 0 0
MyD88-independent TLR4 cascade R-HSA-166166 6.580466e-02 1.182 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 6.580466e-02 1.182 0 0
PTEN Regulation R-HSA-6807070 6.723305e-02 1.172 0 0
ER-Phagosome pathway R-HSA-1236974 6.876032e-02 1.163 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 7.044062e-02 1.152 0 0
TBC/RABGAPs R-HSA-8854214 7.140877e-02 1.146 0 0
Signaling by FGFR4 R-HSA-5654743 7.140877e-02 1.146 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 7.159752e-02 1.145 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.159752e-02 1.145 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.346496e-02 1.134 0 0
Hedgehog ligand biogenesis R-HSA-5358346 7.346496e-02 1.134 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 7.530120e-02 1.123 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 7.677166e-02 1.115 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 7.677166e-02 1.115 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 7.677166e-02 1.115 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 7.677166e-02 1.115 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 7.677166e-02 1.115 0 0
IRAK1 recruits IKK complex R-HSA-937039 7.677166e-02 1.115 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 7.677166e-02 1.115 0 0
EPHB-mediated forward signaling R-HSA-3928662 7.827116e-02 1.106 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 7.861809e-02 1.104 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 7.861809e-02 1.104 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 7.861809e-02 1.104 0 0
Platelet degranulation R-HSA-114608 7.864985e-02 1.104 0 0
Neurexins and neuroligins R-HSA-6794361 7.992319e-02 1.097 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 8.008033e-02 1.096 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 8.063675e-02 1.093 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 8.063675e-02 1.093 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 8.063675e-02 1.093 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 8.063675e-02 1.093 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 8.063675e-02 1.093 0 0
Deadenylation of mRNA R-HSA-429947 8.106876e-02 1.091 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 8.106876e-02 1.091 0 0
Neurodegenerative Diseases R-HSA-8863678 8.106876e-02 1.091 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 8.123949e-02 1.090 0 0
PKA activation R-HSA-163615 8.123949e-02 1.090 0 0
Presynaptic function of Kainate receptors R-HSA-500657 8.123949e-02 1.090 0 0
Regulation of insulin secretion R-HSA-422356 8.177355e-02 1.087 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 8.285874e-02 1.082 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 8.374035e-02 1.077 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 8.552133e-02 1.068 0 0
Signaling by FGFR3 R-HSA-5654741 8.552133e-02 1.068 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 8.552133e-02 1.068 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.552133e-02 1.068 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.552133e-02 1.068 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.702099e-02 1.060 0 0
Viral Messenger RNA Synthesis R-HSA-168325 8.702099e-02 1.060 0 0
G0 and Early G1 R-HSA-1538133 8.752429e-02 1.058 0 0
Protein folding R-HSA-391251 8.860986e-02 1.053 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 8.883681e-02 1.051 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 8.883681e-02 1.051 0 0
MET activates PTPN11 R-HSA-8865999 8.883681e-02 1.051 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 9.084153e-02 1.042 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 9.084153e-02 1.042 0 0
Interleukin-6 signaling R-HSA-1059683 9.084153e-02 1.042 0 0
Long-term potentiation R-HSA-9620244 9.120385e-02 1.040 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 9.124117e-02 1.040 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.124117e-02 1.040 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 9.295809e-02 1.032 0 0
Translesion Synthesis by POLH R-HSA-110320 9.306531e-02 1.031 0 0
Drug resistance of KIT mutants R-HSA-9669937 9.436149e-02 1.025 0 0
KIT mutants bind TKIs R-HSA-9669921 9.436149e-02 1.025 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 9.436149e-02 1.025 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 9.436149e-02 1.025 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 9.436149e-02 1.025 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 9.436149e-02 1.025 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 9.436149e-02 1.025 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 9.436149e-02 1.025 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 9.436149e-02 1.025 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 9.436149e-02 1.025 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 9.436149e-02 1.025 0 0
Stimuli-sensing channels R-HSA-2672351 9.480392e-02 1.023 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 9.610526e-02 1.017 0 0
G-protein beta:gamma signalling R-HSA-397795 9.687157e-02 1.014 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 9.687157e-02 1.014 0 0
FGFR1 mutant receptor activation R-HSA-1839124 9.687157e-02 1.014 0 0
PIP3 activates AKT signaling R-HSA-1257604 9.714687e-02 1.013 0 0
Interleukin-1 signaling R-HSA-9020702 9.731350e-02 1.012 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 9.756227e-02 1.011 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 9.756227e-02 1.011 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 9.950727e-02 1.002 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.988534e-02 1.000 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.000684e-01 1.000 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.019911e-01 0.991 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.026938e-01 0.988 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.043413e-01 0.982 0 0
CRMPs in Sema3A signaling R-HSA-399956 1.060458e-01 0.975 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 1.067466e-01 0.972 0 0
Signaling by NTRKs R-HSA-166520 1.087335e-01 0.964 0 0
Signaling by FGFR1 R-HSA-5654736 1.091407e-01 0.962 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.091407e-01 0.962 0 0
NRAGE signals death through JNK R-HSA-193648 1.091407e-01 0.962 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 1.134147e-01 0.945 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.134147e-01 0.945 0 0
Cristae formation R-HSA-8949613 1.134147e-01 0.945 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.134147e-01 0.945 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.134147e-01 0.945 0 0
Inositol phosphate metabolism R-HSA-1483249 1.169353e-01 0.932 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.171392e-01 0.931 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 1.171392e-01 0.931 0 0
Interferon Signaling R-HSA-913531 1.180329e-01 0.928 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 1.180593e-01 0.928 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.181451e-01 0.928 0 0
ALK mutants bind TKIs R-HSA-9700645 1.181451e-01 0.928 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.181451e-01 0.928 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.181451e-01 0.928 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 1.191710e-01 0.924 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.191710e-01 0.924 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.191710e-01 0.924 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.191710e-01 0.924 0 0
Basigin interactions R-HSA-210991 1.191710e-01 0.924 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 1.191710e-01 0.924 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.201252e-01 0.920 0 0
Regulation of gap junction activity R-HSA-191650 1.201252e-01 0.920 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.201252e-01 0.920 0 0
Dopamine receptors R-HSA-390651 1.201252e-01 0.920 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.201252e-01 0.920 0 0
Vesicle-mediated transport R-HSA-5653656 1.219373e-01 0.914 0 0
Processive synthesis on the lagging strand R-HSA-69183 1.223154e-01 0.913 0 0
Translesion synthesis by REV1 R-HSA-110312 1.223154e-01 0.913 0 0
Protein methylation R-HSA-8876725 1.223154e-01 0.913 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.223154e-01 0.913 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.245674e-01 0.905 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 1.254549e-01 0.902 0 0
Dual incision in TC-NER R-HSA-6782135 1.257555e-01 0.900 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.283871e-01 0.891 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.798239e-01 0.745 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.798239e-01 0.745 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 1.798239e-01 0.745 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 1.798239e-01 0.745 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 2.572261e-01 0.590 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 2.572261e-01 0.590 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 2.572261e-01 0.590 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.572261e-01 0.590 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 2.572261e-01 0.590 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 2.572261e-01 0.590 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.572261e-01 0.590 0 0
Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 R-HSA-9916720 2.572261e-01 0.590 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 2.572261e-01 0.590 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 1.536240e-01 0.814 0 0
IRS activation R-HSA-74713 1.536240e-01 0.814 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.536240e-01 0.814 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 1.886380e-01 0.724 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.886380e-01 0.724 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 1.886380e-01 0.724 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.886380e-01 0.724 0 0
PI3K/AKT activation R-HSA-198203 1.401715e-01 0.853 0 0
2-LTR circle formation R-HSA-164843 1.401715e-01 0.853 0 0
STAT5 Activation R-HSA-9645135 2.245835e-01 0.649 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.245835e-01 0.649 0 0
Translesion synthesis by POLI R-HSA-5656121 1.395728e-01 0.855 0 0
Activation of RAC1 R-HSA-428540 1.877571e-01 0.726 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.609732e-01 0.583 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 2.609732e-01 0.583 0 0
Disinhibition of SNARE formation R-HSA-114516 2.609732e-01 0.583 0 0
Recycling of eIF2:GDP R-HSA-72731 2.609732e-01 0.583 0 0
SOS-mediated signalling R-HSA-112412 2.609732e-01 0.583 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 1.577341e-01 0.802 0 0
Translesion synthesis by POLK R-HSA-5655862 1.577341e-01 0.802 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 2.129232e-01 0.672 0 0
Leading Strand Synthesis R-HSA-69109 2.129232e-01 0.672 0 0
Polymerase switching R-HSA-69091 2.129232e-01 0.672 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.333812e-01 0.875 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 2.387532e-01 0.622 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 1.964094e-01 0.707 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.801208e-01 0.744 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.650281e-01 0.782 0 0
HDMs demethylate histones R-HSA-3214842 1.969039e-01 0.706 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 2.141990e-01 0.669 0 0
Lagging Strand Synthesis R-HSA-69186 2.589098e-01 0.587 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 1.894806e-01 0.722 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 1.894806e-01 0.722 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.723010e-01 0.764 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.384628e-01 0.623 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.388129e-01 0.622 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 2.282242e-01 0.642 0 0
Signaling by SCF-KIT R-HSA-1433557 2.456375e-01 0.610 0 0
MET promotes cell motility R-HSA-8875878 1.635913e-01 0.786 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.387532e-01 0.622 0 0
Activation of the pre-replicative complex R-HSA-68962 1.512895e-01 0.820 0 0
DNA strand elongation R-HSA-69190 1.792728e-01 0.746 0 0
Integration of provirus R-HSA-162592 1.877571e-01 0.726 0 0
Repression of WNT target genes R-HSA-4641265 2.129232e-01 0.672 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.571417e-01 0.804 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.536240e-01 0.814 0 0
GPER1 signaling R-HSA-9634597 1.964464e-01 0.707 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.601158e-01 0.796 0 0
Regulation of IFNG signaling R-HSA-877312 2.129232e-01 0.672 0 0
Budding and maturation of HIV virion R-HSA-162588 1.650281e-01 0.782 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 2.589098e-01 0.587 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 1.483080e-01 0.829 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.307118e-01 0.884 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 1.574120e-01 0.803 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 2.085631e-01 0.681 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 1.536240e-01 0.814 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.512895e-01 0.820 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 1.607590e-01 0.794 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 1.577341e-01 0.802 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.129232e-01 0.672 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 2.311177e-01 0.636 0 0
G alpha (z) signalling events R-HSA-418597 1.785751e-01 0.748 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 1.886380e-01 0.724 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 1.886380e-01 0.724 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.250361e-01 0.648 0 0
G1 Phase R-HSA-69236 1.495931e-01 0.825 0 0
Cyclin D associated events in G1 R-HSA-69231 1.495931e-01 0.825 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 1.842028e-01 0.735 0 0
Signaling by FGFR2 R-HSA-5654738 1.703017e-01 0.769 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.316062e-01 0.881 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 1.577341e-01 0.802 0 0
MAP kinase activation R-HSA-450294 1.530852e-01 0.815 0 0
Antigen processing-Cross presentation R-HSA-1236975 2.177181e-01 0.662 0 0
Adaptive Immune System R-HSA-1280218 1.884186e-01 0.725 0 0
Rab regulation of trafficking R-HSA-9007101 1.624516e-01 0.789 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.399859e-01 0.854 0 0
Interleukin-17 signaling R-HSA-448424 2.502098e-01 0.602 0 0
SDK interactions R-HSA-373756 1.798239e-01 0.745 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 2.572261e-01 0.590 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.572261e-01 0.590 0 0
Manipulation of host energy metabolism R-HSA-9636667 2.572261e-01 0.590 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 1.395728e-01 0.855 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.609732e-01 0.583 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 1.767102e-01 0.753 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 2.387532e-01 0.622 0 0
PKA activation in glucagon signalling R-HSA-164378 1.964094e-01 0.707 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.723010e-01 0.764 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 2.604155e-01 0.584 0 0
Interleukin-1 family signaling R-HSA-446652 2.505923e-01 0.601 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.571417e-01 0.804 0 0
TCR signaling R-HSA-202403 1.614755e-01 0.792 0 0
MHC class II antigen presentation R-HSA-2132295 2.079087e-01 0.682 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 1.577341e-01 0.802 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.228359e-01 0.652 0 0
Aquaporin-mediated transport R-HSA-445717 1.530852e-01 0.815 0 0
Circadian clock R-HSA-9909396 2.228359e-01 0.652 0 0
Integration of energy metabolism R-HSA-163685 1.913175e-01 0.718 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.939897e-01 0.712 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 1.939897e-01 0.712 0 0
Ion homeostasis R-HSA-5578775 1.897625e-01 0.722 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.609732e-01 0.583 0 0
Cellular response to hypoxia R-HSA-1234174 1.936963e-01 0.713 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 2.500997e-01 0.602 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.828300e-01 0.738 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 1.483080e-01 0.829 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.572261e-01 0.590 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.245835e-01 0.649 0 0
Platelet sensitization by LDL R-HSA-432142 1.964094e-01 0.707 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.792728e-01 0.746 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 1.370459e-01 0.863 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 2.456375e-01 0.610 0 0
Oncogene Induced Senescence R-HSA-2559585 2.406104e-01 0.619 0 0
Assembly Of The HIV Virion R-HSA-175474 1.333812e-01 0.875 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.030118e-01 0.692 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.578061e-01 0.802 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 1.769776e-01 0.752 0 0
PERK regulates gene expression R-HSA-381042 2.406104e-01 0.619 0 0
Regulated Necrosis R-HSA-5218859 1.400606e-01 0.854 0 0
ABC-family proteins mediated transport R-HSA-382556 1.453044e-01 0.838 0 0
Infectious disease R-HSA-5663205 2.114500e-01 0.675 0 0
FOXO-mediated transcription R-HSA-9614085 1.381921e-01 0.860 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 1.469209e-01 0.833 0 0
Pyruvate metabolism R-HSA-70268 2.491097e-01 0.604 0 0
ABC transporter disorders R-HSA-5619084 2.388129e-01 0.622 0 0
Signaling by Leptin R-HSA-2586552 1.401715e-01 0.853 0 0
Pyroptosis R-HSA-5620971 2.500997e-01 0.602 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 2.609732e-01 0.583 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 1.577341e-01 0.802 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 2.589098e-01 0.587 0 0
Interleukin-7 signaling R-HSA-1266695 1.969039e-01 0.706 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.558945e-01 0.807 0 0
IRE1alpha activates chaperones R-HSA-381070 2.088261e-01 0.680 0 0
Regulation of BACH1 activity R-HSA-9708530 1.395728e-01 0.855 0 0
Glycogen storage diseases R-HSA-3229121 1.767102e-01 0.753 0 0
Glycogen synthesis R-HSA-3322077 2.376024e-01 0.624 0 0
Regulation of KIT signaling R-HSA-1433559 2.650701e-01 0.577 0 0
Removal of the Flap Intermediate R-HSA-69166 2.650701e-01 0.577 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 2.650701e-01 0.577 0 0
HDL assembly R-HSA-8963896 2.650701e-01 0.577 0 0
Neutrophil degranulation R-HSA-6798695 2.666758e-01 0.574 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.805691e-01 0.552 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.805691e-01 0.552 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 2.805691e-01 0.552 0 0
Signaling by Hedgehog R-HSA-5358351 2.818444e-01 0.550 0 0
Signaling by FGFR R-HSA-190236 2.895361e-01 0.538 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.895361e-01 0.538 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.895361e-01 0.538 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.895361e-01 0.538 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 2.901300e-01 0.537 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 2.901300e-01 0.537 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 2.907218e-01 0.537 0 0
Regulation of pyruvate metabolism R-HSA-9861718 2.907218e-01 0.537 0 0
G beta:gamma signalling through BTK R-HSA-8964315 2.917080e-01 0.535 0 0
DCC mediated attractive signaling R-HSA-418885 2.917080e-01 0.535 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.917080e-01 0.535 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 2.927517e-01 0.534 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 2.974037e-01 0.527 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 2.974037e-01 0.527 0 0
Adrenoceptors R-HSA-390696 2.974037e-01 0.527 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.981443e-01 0.526 0 0
Signaling by FGFR in disease R-HSA-1226099 2.989949e-01 0.524 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 3.024921e-01 0.519 0 0
TNF signaling R-HSA-75893 3.042722e-01 0.517 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 3.042722e-01 0.517 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 3.061606e-01 0.514 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 3.063720e-01 0.514 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 3.063720e-01 0.514 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.068320e-01 0.513 0 0
RAS processing R-HSA-9648002 3.070973e-01 0.513 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.070973e-01 0.513 0 0
Signaling by TGFB family members R-HSA-9006936 3.170304e-01 0.499 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 3.172758e-01 0.499 0 0
Phosphorylation of the APC/C R-HSA-176412 3.185134e-01 0.497 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.185134e-01 0.497 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 3.185134e-01 0.497 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.217559e-01 0.492 0 0
Mitochondrial biogenesis R-HSA-1592230 3.227776e-01 0.491 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 3.245941e-01 0.489 0 0
Syndecan interactions R-HSA-3000170 3.245941e-01 0.489 0 0
Growth hormone receptor signaling R-HSA-982772 3.245941e-01 0.489 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 3.255502e-01 0.487 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.273278e-01 0.485 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.273278e-01 0.485 0 0
Defective AHCY causes HMAHCHD R-HSA-5578997 3.273278e-01 0.485 0 0
Signalling to ERK5 R-HSA-198765 3.273278e-01 0.485 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.273278e-01 0.485 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 3.329563e-01 0.478 0 0
p75NTR regulates axonogenesis R-HSA-193697 3.335433e-01 0.477 0 0
Calcineurin activates NFAT R-HSA-2025928 3.335433e-01 0.477 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.335433e-01 0.477 0 0
Unwinding of DNA R-HSA-176974 3.335433e-01 0.477 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.335433e-01 0.477 0 0
Interleukin-1 processing R-HSA-448706 3.335433e-01 0.477 0 0
Regulated proteolysis of p75NTR R-HSA-193692 3.335433e-01 0.477 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.335433e-01 0.477 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 3.335433e-01 0.477 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.414886e-01 0.467 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 3.414886e-01 0.467 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.423495e-01 0.466 0 0
Toll-like Receptor Cascades R-HSA-168898 3.435396e-01 0.464 0 0
Nuclear RNA decay R-HSA-9930044 3.448484e-01 0.462 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.448484e-01 0.462 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.448484e-01 0.462 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.453454e-01 0.462 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.453454e-01 0.462 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 3.467940e-01 0.460 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 3.467940e-01 0.460 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 3.467940e-01 0.460 0 0
Interleukin-6 family signaling R-HSA-6783589 3.467940e-01 0.460 0 0
Regulation of beta-cell development R-HSA-186712 3.477777e-01 0.459 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 3.500706e-01 0.456 0 0
PI3K Cascade R-HSA-109704 3.532992e-01 0.452 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 3.598506e-01 0.444 0 0
Autophagy R-HSA-9612973 3.671332e-01 0.435 0 0
Selective autophagy R-HSA-9663891 3.686271e-01 0.433 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 3.690155e-01 0.433 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 3.690155e-01 0.433 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 3.691228e-01 0.433 0 0
MAPK3 (ERK1) activation R-HSA-110056 3.691228e-01 0.433 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 3.691228e-01 0.433 0 0
DNA replication initiation R-HSA-68952 3.691228e-01 0.433 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 3.691228e-01 0.433 0 0
Regulation of CDH11 function R-HSA-9762292 3.691228e-01 0.433 0 0
Signal attenuation R-HSA-74749 3.691228e-01 0.433 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.691228e-01 0.433 0 0
Hemostasis R-HSA-109582 3.717091e-01 0.430 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.720762e-01 0.429 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.720762e-01 0.429 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 3.720762e-01 0.429 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 3.720762e-01 0.429 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 3.720762e-01 0.429 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 3.836002e-01 0.416 0 0
Signal amplification R-HSA-392518 3.836002e-01 0.416 0 0
eNOS activation R-HSA-203615 3.836002e-01 0.416 0 0
Calnexin/calreticulin cycle R-HSA-901042 3.836002e-01 0.416 0 0
NOD1/2 Signaling Pathway R-HSA-168638 3.836002e-01 0.416 0 0
Mitophagy R-HSA-5205647 3.836002e-01 0.416 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 3.889513e-01 0.410 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 3.908171e-01 0.408 0 0
Axonal growth stimulation R-HSA-209563 3.908171e-01 0.408 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 3.908171e-01 0.408 0 0
Defective ABCA1 causes TGD R-HSA-5682113 3.908171e-01 0.408 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 3.908171e-01 0.408 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 3.908171e-01 0.408 0 0
MET interacts with TNS proteins R-HSA-8875513 3.908171e-01 0.408 0 0
Histamine receptors R-HSA-390650 3.908171e-01 0.408 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 3.911868e-01 0.408 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 3.911868e-01 0.408 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 3.911868e-01 0.408 0 0
Suppression of phagosomal maturation R-HSA-9637687 3.911868e-01 0.408 0 0
Heme signaling R-HSA-9707616 3.920042e-01 0.407 0 0
Downstream TCR signaling R-HSA-202424 3.933912e-01 0.405 0 0
Response of Mtb to phagocytosis R-HSA-9637690 3.936534e-01 0.405 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 3.975121e-01 0.401 0 0
GAB1 signalosome R-HSA-180292 3.985909e-01 0.399 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.985909e-01 0.399 0 0
Mismatch Repair R-HSA-5358508 3.985909e-01 0.399 0 0
Macroautophagy R-HSA-1632852 4.001470e-01 0.398 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.039260e-01 0.394 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.039260e-01 0.394 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.039260e-01 0.394 0 0
LGI-ADAM interactions R-HSA-5682910 4.039260e-01 0.394 0 0
Bicarbonate transporters R-HSA-425381 4.039260e-01 0.394 0 0
Signaling by APC mutants R-HSA-4839744 4.039260e-01 0.394 0 0
PECAM1 interactions R-HSA-210990 4.039260e-01 0.394 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.039260e-01 0.394 0 0
Netrin-1 signaling R-HSA-373752 4.110526e-01 0.386 0 0
Ca2+ pathway R-HSA-4086398 4.113803e-01 0.386 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 4.132410e-01 0.384 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.132410e-01 0.384 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 4.132410e-01 0.384 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.132410e-01 0.384 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 4.132410e-01 0.384 0 0
Insulin processing R-HSA-264876 4.132410e-01 0.384 0 0
GPVI-mediated activation cascade R-HSA-114604 4.222396e-01 0.374 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 4.247872e-01 0.372 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 4.247872e-01 0.372 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 4.247872e-01 0.372 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 4.247872e-01 0.372 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.247872e-01 0.372 0 0
Signaling by ERBB4 R-HSA-1236394 4.252445e-01 0.371 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 4.327752e-01 0.364 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 4.346867e-01 0.362 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 4.351164e-01 0.361 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.377827e-01 0.359 0 0
Signaling by GSK3beta mutants R-HSA-5339716 4.377827e-01 0.359 0 0
Signaling by AMER1 mutants R-HSA-4839748 4.377827e-01 0.359 0 0
Signaling by AXIN mutants R-HSA-4839735 4.377827e-01 0.359 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 4.377827e-01 0.359 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.377827e-01 0.359 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.377827e-01 0.359 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 4.443457e-01 0.352 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 4.456687e-01 0.351 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.470265e-01 0.350 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.470265e-01 0.350 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.483175e-01 0.348 0 0
HCN channels R-HSA-1296061 4.483175e-01 0.348 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.483175e-01 0.348 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.483175e-01 0.348 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.483175e-01 0.348 0 0
Alanine metabolism R-HSA-8964540 4.483175e-01 0.348 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 4.483175e-01 0.348 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.483175e-01 0.348 0 0
NADE modulates death signalling R-HSA-205025 4.483175e-01 0.348 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.483175e-01 0.348 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 4.505751e-01 0.346 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.505751e-01 0.346 0 0
Co-inhibition by CTLA4 R-HSA-389513 4.505751e-01 0.346 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 4.505751e-01 0.346 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 4.505751e-01 0.346 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 4.505751e-01 0.346 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 4.505751e-01 0.346 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 4.505751e-01 0.346 0 0
Signal transduction by L1 R-HSA-445144 4.505751e-01 0.346 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 4.505751e-01 0.346 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 4.543410e-01 0.343 0 0
Signaling by Erythropoietin R-HSA-9006335 4.567564e-01 0.340 0 0
Glucagon-type ligand receptors R-HSA-420092 4.567564e-01 0.340 0 0
Regulation of gene expression in beta cells R-HSA-210745 4.567564e-01 0.340 0 0
IRS-mediated signalling R-HSA-112399 4.645080e-01 0.333 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.705616e-01 0.327 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 4.705616e-01 0.327 0 0
Scavenging by Class F Receptors R-HSA-3000484 4.705616e-01 0.327 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 4.705616e-01 0.327 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 4.705616e-01 0.327 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 4.705616e-01 0.327 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 4.705616e-01 0.327 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.705616e-01 0.327 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 4.705616e-01 0.327 0 0
G-protein activation R-HSA-202040 4.758764e-01 0.323 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 4.758764e-01 0.323 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.781093e-01 0.320 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.781093e-01 0.320 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.781093e-01 0.320 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 4.781093e-01 0.320 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.781093e-01 0.320 0 0
Interleukin-37 signaling R-HSA-9008059 4.781093e-01 0.320 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 4.792363e-01 0.319 0 0
Signaling by ALK R-HSA-201556 4.792363e-01 0.319 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 4.797110e-01 0.319 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 4.797110e-01 0.319 0 0
Gluconeogenesis R-HSA-70263 4.798409e-01 0.319 0 0
Co-stimulation by CD28 R-HSA-389356 4.798409e-01 0.319 0 0
Sensory processing of sound R-HSA-9659379 4.939375e-01 0.306 0 0
Extension of Telomeres R-HSA-180786 4.956815e-01 0.305 0 0
Peroxisomal protein import R-HSA-9033241 4.956815e-01 0.305 0 0
Gap junction trafficking and regulation R-HSA-157858 4.966914e-01 0.304 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 4.966914e-01 0.304 0 0
Generation of second messenger molecules R-HSA-202433 4.978282e-01 0.303 0 0
Glycogen metabolism R-HSA-8982491 4.978282e-01 0.303 0 0
Trafficking of AMPA receptors R-HSA-399719 4.991288e-01 0.302 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 5.003936e-01 0.301 0 0
G2 Phase R-HSA-68911 5.003936e-01 0.301 0 0
PTK6 Down-Regulation R-HSA-8849472 5.003936e-01 0.301 0 0
Reelin signalling pathway R-HSA-8866376 5.003936e-01 0.301 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.003936e-01 0.301 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.003936e-01 0.301 0 0
Co-inhibition by BTLA R-HSA-9927353 5.003936e-01 0.301 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 5.003936e-01 0.301 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 5.003936e-01 0.301 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 5.003936e-01 0.301 0 0
Processing of SMDT1 R-HSA-8949664 5.021646e-01 0.299 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 5.021646e-01 0.299 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 5.036681e-01 0.298 0 0
PKR-mediated signaling R-HSA-9833482 5.074440e-01 0.295 0 0
tRNA Aminoacylation R-HSA-379724 5.110572e-01 0.292 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 5.233369e-01 0.281 0 0
Signaling by KIT in disease R-HSA-9669938 5.247601e-01 0.280 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 5.247601e-01 0.280 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 5.247601e-01 0.280 0 0
FGFR2 alternative splicing R-HSA-6803529 5.247601e-01 0.280 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 5.247601e-01 0.280 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.262670e-01 0.279 0 0
Formation of paraxial mesoderm R-HSA-9793380 5.262670e-01 0.279 0 0
Protein localization R-HSA-9609507 5.277506e-01 0.278 0 0
The phototransduction cascade R-HSA-2514856 5.297983e-01 0.276 0 0
Retrograde neurotrophin signalling R-HSA-177504 5.325216e-01 0.274 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 5.325216e-01 0.274 0 0
Signaling by FGFR4 in disease R-HSA-5655291 5.325216e-01 0.274 0 0
Signal regulatory protein family interactions R-HSA-391160 5.325216e-01 0.274 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.325216e-01 0.274 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 5.342095e-01 0.272 0 0
Translation of Structural Proteins R-HSA-9683701 5.342095e-01 0.272 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 5.400065e-01 0.268 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 5.400065e-01 0.268 0 0
Mitochondrial protein import R-HSA-1268020 5.412932e-01 0.267 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 5.460108e-01 0.263 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 5.472528e-01 0.262 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.475567e-01 0.262 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.475567e-01 0.262 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.475567e-01 0.262 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 5.475567e-01 0.262 0 0
Pentose phosphate pathway disease R-HSA-6791465 5.475567e-01 0.262 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 5.475567e-01 0.262 0 0
Cam-PDE 1 activation R-HSA-111957 5.475567e-01 0.262 0 0
Synthesis of PS R-HSA-1483101 5.475567e-01 0.262 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.475567e-01 0.262 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 5.475567e-01 0.262 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.475567e-01 0.262 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 5.475567e-01 0.262 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 5.475567e-01 0.262 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 5.482383e-01 0.261 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 5.482383e-01 0.261 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 5.561190e-01 0.255 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 5.561195e-01 0.255 0 0
Effects of PIP2 hydrolysis R-HSA-114508 5.597960e-01 0.252 0 0
Erythropoietin activates RAS R-HSA-9027284 5.615863e-01 0.251 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 5.615863e-01 0.251 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 5.615863e-01 0.251 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 5.615863e-01 0.251 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 5.615863e-01 0.251 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 5.619697e-01 0.250 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 5.650416e-01 0.248 0 0
Cellular response to chemical stress R-HSA-9711123 5.666076e-01 0.247 0 0
IGF1R signaling cascade R-HSA-2428924 5.707309e-01 0.244 0 0
Insulin receptor signalling cascade R-HSA-74751 5.707309e-01 0.244 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 5.707309e-01 0.244 0 0
Thromboxane signalling through TP receptor R-HSA-428930 5.710199e-01 0.243 0 0
Plasma lipoprotein assembly R-HSA-8963898 5.710199e-01 0.243 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 5.791142e-01 0.237 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 5.791142e-01 0.237 0 0
Hyaluronan metabolism R-HSA-2142845 5.791142e-01 0.237 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 5.791142e-01 0.237 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 5.791142e-01 0.237 0 0
Ion channel transport R-HSA-983712 5.843106e-01 0.233 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 5.851136e-01 0.233 0 0
Proteasome assembly R-HSA-9907900 5.863871e-01 0.232 0 0
Gap junction trafficking R-HSA-190828 5.863871e-01 0.232 0 0
Amine ligand-binding receptors R-HSA-375280 5.863871e-01 0.232 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 5.893322e-01 0.230 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 5.893322e-01 0.230 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.893322e-01 0.230 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 5.893322e-01 0.230 0 0
Differentiation of T cells R-HSA-9945266 5.893322e-01 0.230 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 5.893322e-01 0.230 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.893322e-01 0.230 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 5.893322e-01 0.230 0 0
HDL clearance R-HSA-8964011 5.902701e-01 0.229 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 5.902701e-01 0.229 0 0
Signaling by LTK in cancer R-HSA-9842640 5.902701e-01 0.229 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 5.902701e-01 0.229 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.902701e-01 0.229 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 5.902701e-01 0.229 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 5.902701e-01 0.229 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 5.902701e-01 0.229 0 0
CREB phosphorylation R-HSA-199920 5.902701e-01 0.229 0 0
Neurofascin interactions R-HSA-447043 5.902701e-01 0.229 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 5.930747e-01 0.227 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 5.930747e-01 0.227 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 5.930747e-01 0.227 0 0
G protein gated Potassium channels R-HSA-1296059 5.930747e-01 0.227 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 5.930747e-01 0.227 0 0
Tight junction interactions R-HSA-420029 5.930747e-01 0.227 0 0
Acyl chain remodelling of PS R-HSA-1482801 5.930747e-01 0.227 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 5.930747e-01 0.227 0 0
TGFBR3 expression R-HSA-9839394 5.930747e-01 0.227 0 0
Adipogenesis R-HSA-9843745 5.952182e-01 0.225 0 0
Potential therapeutics for SARS R-HSA-9679191 5.970940e-01 0.224 0 0
Fanconi Anemia Pathway R-HSA-6783310 6.030564e-01 0.220 0 0
Somitogenesis R-HSA-9824272 6.030564e-01 0.220 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 6.143798e-01 0.212 0 0
Myogenesis R-HSA-525793 6.143798e-01 0.212 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 6.143798e-01 0.212 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 6.157492e-01 0.211 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 6.157492e-01 0.211 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.157492e-01 0.211 0 0
Passive transport by Aquaporins R-HSA-432047 6.157492e-01 0.211 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 6.157492e-01 0.211 0 0
G1/S-Specific Transcription R-HSA-69205 6.162477e-01 0.210 0 0
Triglyceride catabolism R-HSA-163560 6.162477e-01 0.210 0 0
Signaling by TGFBR3 R-HSA-9839373 6.193361e-01 0.208 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 6.267680e-01 0.203 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.289534e-01 0.201 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.289534e-01 0.201 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.289534e-01 0.201 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.289534e-01 0.201 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.289534e-01 0.201 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 6.289534e-01 0.201 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.289534e-01 0.201 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 6.289534e-01 0.201 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.289534e-01 0.201 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.289534e-01 0.201 0 0
Reuptake of GABA R-HSA-888593 6.289534e-01 0.201 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.289534e-01 0.201 0 0
VLDL clearance R-HSA-8964046 6.289534e-01 0.201 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.289534e-01 0.201 0 0
Netrin mediated repulsion signals R-HSA-418886 6.289534e-01 0.201 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 6.349191e-01 0.197 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 6.349191e-01 0.197 0 0
Disease R-HSA-1643685 6.351405e-01 0.197 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 6.352130e-01 0.197 0 0
Disorders of transmembrane transporters R-HSA-5619115 6.396198e-01 0.194 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.408409e-01 0.193 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.408409e-01 0.193 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 6.408409e-01 0.193 0 0
Specification of primordial germ cells R-HSA-9827857 6.408409e-01 0.193 0 0
NGF-stimulated transcription R-HSA-9031628 6.506762e-01 0.187 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 6.512663e-01 0.186 0 0
Telomere Extension By Telomerase R-HSA-171319 6.546825e-01 0.184 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 6.546825e-01 0.184 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 6.546825e-01 0.184 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 6.639866e-01 0.178 0 0
phospho-PLA2 pathway R-HSA-111995 6.639866e-01 0.178 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.639866e-01 0.178 0 0
MET receptor recycling R-HSA-8875656 6.639866e-01 0.178 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 6.639866e-01 0.178 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 6.639866e-01 0.178 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 6.639866e-01 0.178 0 0
FGFR1b ligand binding and activation R-HSA-190370 6.639866e-01 0.178 0 0
Fructose biosynthesis R-HSA-5652227 6.639866e-01 0.178 0 0
Interleukin-9 signaling R-HSA-8985947 6.639866e-01 0.178 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.639866e-01 0.178 0 0
SLC-mediated bile acid transport R-HSA-9958517 6.639866e-01 0.178 0 0
Sodium/Proton exchangers R-HSA-425986 6.639866e-01 0.178 0 0
Alpha-defensins R-HSA-1462054 6.639866e-01 0.178 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 6.646220e-01 0.177 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.646220e-01 0.177 0 0
Synaptic adhesion-like molecules R-HSA-8849932 6.646220e-01 0.177 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.646220e-01 0.177 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.646220e-01 0.177 0 0
Polo-like kinase mediated events R-HSA-156711 6.646220e-01 0.177 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 6.646220e-01 0.177 0 0
Nephron development R-HSA-9831926 6.646220e-01 0.177 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 6.646220e-01 0.177 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.646220e-01 0.177 0 0
RAB geranylgeranylation R-HSA-8873719 6.653137e-01 0.177 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 6.688094e-01 0.175 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 6.736653e-01 0.172 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 6.736653e-01 0.172 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 6.736653e-01 0.172 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 6.736653e-01 0.172 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.736653e-01 0.172 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 6.784691e-01 0.168 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 6.840853e-01 0.165 0 0
Diseases of Immune System R-HSA-5260271 6.840853e-01 0.165 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 6.840853e-01 0.165 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.871164e-01 0.163 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.871164e-01 0.163 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 6.871164e-01 0.163 0 0
The NLRP3 inflammasome R-HSA-844456 6.871164e-01 0.163 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 6.918676e-01 0.160 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 6.957139e-01 0.158 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 6.957139e-01 0.158 0 0
Lipophagy R-HSA-9613354 6.957139e-01 0.158 0 0
WNT mediated activation of DVL R-HSA-201688 6.957139e-01 0.158 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 6.957139e-01 0.158 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 6.957139e-01 0.158 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 6.957139e-01 0.158 0 0
Interleukin-21 signaling R-HSA-9020958 6.957139e-01 0.158 0 0
MAPK1 (ERK2) activation R-HSA-112411 6.957139e-01 0.158 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 6.957139e-01 0.158 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 6.957139e-01 0.158 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 6.957139e-01 0.158 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 7.083549e-01 0.150 0 0
Pregnenolone biosynthesis R-HSA-196108 7.083549e-01 0.150 0 0
Formation of definitive endoderm R-HSA-9823730 7.083549e-01 0.150 0 0
Downstream signal transduction R-HSA-186763 7.092937e-01 0.149 0 0
Iron uptake and transport R-HSA-917937 7.141391e-01 0.146 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.146679e-01 0.146 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 7.244472e-01 0.140 0 0
Binding and entry of HIV virion R-HSA-173107 7.244472e-01 0.140 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 7.244472e-01 0.140 0 0
CASP4 inflammasome assembly R-HSA-9948001 7.244472e-01 0.140 0 0
Interleukin-27 signaling R-HSA-9020956 7.244472e-01 0.140 0 0
Sperm Motility And Taxes R-HSA-1300642 7.244472e-01 0.140 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 7.244472e-01 0.140 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 7.244472e-01 0.140 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.259516e-01 0.139 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 7.259516e-01 0.139 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.283741e-01 0.138 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 7.283741e-01 0.138 0 0
ERK/MAPK targets R-HSA-198753 7.283741e-01 0.138 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.283741e-01 0.138 0 0
Activation of GABAB receptors R-HSA-991365 7.291202e-01 0.137 0 0
GABA B receptor activation R-HSA-977444 7.291202e-01 0.137 0 0
Interferon alpha/beta signaling R-HSA-909733 7.304486e-01 0.136 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 7.418524e-01 0.130 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 7.418524e-01 0.130 0 0
Cardiogenesis R-HSA-9733709 7.418524e-01 0.130 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 7.418524e-01 0.130 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.472149e-01 0.127 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.472149e-01 0.127 0 0
Mitochondrial calcium ion transport R-HSA-8949215 7.472149e-01 0.127 0 0
Chylomicron assembly R-HSA-8963888 7.504687e-01 0.125 0 0
Ionotropic activity of kainate receptors R-HSA-451306 7.504687e-01 0.125 0 0
vRNP Assembly R-HSA-192905 7.504687e-01 0.125 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.504687e-01 0.125 0 0
Suppression of apoptosis R-HSA-9635465 7.504687e-01 0.125 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.504687e-01 0.125 0 0
Interleukin-2 signaling R-HSA-9020558 7.504687e-01 0.125 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.504687e-01 0.125 0 0
Neddylation R-HSA-8951664 7.520452e-01 0.124 0 0
Resolution of D-Loop Structures R-HSA-5693537 7.570098e-01 0.121 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 7.570098e-01 0.121 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.570098e-01 0.121 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.573978e-01 0.121 0 0
Interferon gamma signaling R-HSA-877300 7.618751e-01 0.118 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.649213e-01 0.116 0 0
Notch-HLH transcription pathway R-HSA-350054 7.649213e-01 0.116 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.649213e-01 0.116 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.649213e-01 0.116 0 0
LDL clearance R-HSA-8964038 7.649213e-01 0.116 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.649213e-01 0.116 0 0
tRNA processing R-HSA-72306 7.688074e-01 0.114 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 7.691707e-01 0.114 0 0
Immune System R-HSA-168256 7.719166e-01 0.112 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 7.740344e-01 0.111 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 7.740344e-01 0.111 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.740344e-01 0.111 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 7.740344e-01 0.111 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 7.740344e-01 0.111 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 7.740344e-01 0.111 0 0
Plasmalogen biosynthesis R-HSA-75896 7.740344e-01 0.111 0 0
ERKs are inactivated R-HSA-202670 7.740344e-01 0.111 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 7.740344e-01 0.111 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 7.740344e-01 0.111 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 7.740344e-01 0.111 0 0
Sodium/Calcium exchangers R-HSA-425561 7.740344e-01 0.111 0 0
Uptake of dietary cobalamins into enterocytes R-HSA-9758881 7.740344e-01 0.111 0 0
MITF-M-dependent gene expression R-HSA-9856651 7.765492e-01 0.110 0 0
Transmission across Chemical Synapses R-HSA-112315 7.789651e-01 0.108 0 0
Diseases of DNA repair R-HSA-9675135 7.814422e-01 0.107 0 0
Interleukin-20 family signaling R-HSA-8854691 7.815393e-01 0.107 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 7.815393e-01 0.107 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 7.847064e-01 0.105 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 7.851614e-01 0.105 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.851614e-01 0.105 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 7.851614e-01 0.105 0 0
Signaling by Insulin receptor R-HSA-74752 7.903350e-01 0.102 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 7.904014e-01 0.102 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.905511e-01 0.102 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 7.922002e-01 0.101 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 7.950331e-01 0.100 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 7.953757e-01 0.099 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 7.953757e-01 0.099 0 0
Interleukin-35 Signalling R-HSA-8984722 7.953757e-01 0.099 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 7.953757e-01 0.099 0 0
Signaling by LTK R-HSA-9842663 7.953757e-01 0.099 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 7.953757e-01 0.099 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 7.953757e-01 0.099 0 0
Estrogen biosynthesis R-HSA-193144 7.953757e-01 0.099 0 0
Interleukin-15 signaling R-HSA-8983432 7.953757e-01 0.099 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 7.953757e-01 0.099 0 0
OAS antiviral response R-HSA-8983711 7.953757e-01 0.099 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 7.971167e-01 0.098 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.971167e-01 0.098 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 7.971167e-01 0.098 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 7.981931e-01 0.098 0 0
RNA Polymerase III Transcription R-HSA-74158 7.981931e-01 0.098 0 0
Glycosphingolipid transport R-HSA-9845576 7.981931e-01 0.098 0 0
RUNX2 regulates bone development R-HSA-8941326 7.981931e-01 0.098 0 0
Metabolism of polyamines R-HSA-351202 8.024918e-01 0.096 0 0
Intraflagellar transport R-HSA-5620924 8.044245e-01 0.095 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.071001e-01 0.093 0 0
Mitochondrial protein degradation R-HSA-9837999 8.071001e-01 0.093 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.105563e-01 0.091 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.117017e-01 0.091 0 0
Hyaluronan degradation R-HSA-2160916 8.117017e-01 0.091 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.117017e-01 0.091 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 8.147026e-01 0.089 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 8.147026e-01 0.089 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.147026e-01 0.089 0 0
Formation of axial mesoderm R-HSA-9796292 8.147026e-01 0.089 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 8.147026e-01 0.089 0 0
Chylomicron remodeling R-HSA-8963901 8.147026e-01 0.089 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.147026e-01 0.089 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.147026e-01 0.089 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.147026e-01 0.089 0 0
Maturation of nucleoprotein R-HSA-9683610 8.147026e-01 0.089 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 8.218608e-01 0.085 0 0
Signaling by PDGF R-HSA-186797 8.218608e-01 0.085 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.222726e-01 0.085 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.253428e-01 0.083 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 8.292988e-01 0.081 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.293249e-01 0.081 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.322052e-01 0.080 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.322052e-01 0.080 0 0
Hydrolysis of LPC R-HSA-1483115 8.322052e-01 0.080 0 0
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA R-HSA-77310 8.322052e-01 0.080 0 0
Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-HSA-77350 8.322052e-01 0.080 0 0
Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-HSA-77348 8.322052e-01 0.080 0 0
Physiological factors R-HSA-5578768 8.322052e-01 0.080 0 0
Prolactin receptor signaling R-HSA-1170546 8.322052e-01 0.080 0 0
Malate-aspartate shuttle R-HSA-9856872 8.322052e-01 0.080 0 0
Non-canonical inflammasome activation R-HSA-9686114 8.322052e-01 0.080 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.322052e-01 0.080 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.329534e-01 0.079 0 0
Pentose phosphate pathway R-HSA-71336 8.333647e-01 0.079 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.333647e-01 0.079 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.380881e-01 0.077 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.380881e-01 0.077 0 0
Interleukin-2 family signaling R-HSA-451927 8.438557e-01 0.074 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.444814e-01 0.073 0 0
Translation of Structural Proteins R-HSA-9694635 8.453376e-01 0.073 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.480554e-01 0.072 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.480554e-01 0.072 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.480554e-01 0.072 0 0
p38MAPK events R-HSA-171007 8.480554e-01 0.072 0 0
Beta oxidation of butanoyl-CoA to acetyl-CoA R-HSA-77352 8.480554e-01 0.072 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 8.480554e-01 0.072 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.480554e-01 0.072 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.480554e-01 0.072 0 0
DNA Damage Reversal R-HSA-73942 8.480554e-01 0.072 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 8.488117e-01 0.071 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.499850e-01 0.071 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 8.499850e-01 0.071 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.499850e-01 0.071 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.499850e-01 0.071 0 0
Inflammasomes R-HSA-622312 8.499850e-01 0.071 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.532773e-01 0.069 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.533428e-01 0.069 0 0
Cardiac conduction R-HSA-5576891 8.602319e-01 0.065 0 0
mRNA Capping R-HSA-72086 8.610802e-01 0.065 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.624092e-01 0.064 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.624092e-01 0.064 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 8.624092e-01 0.064 0 0
Killing mechanisms R-HSA-9664420 8.624092e-01 0.064 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.624092e-01 0.064 0 0
Atorvastatin ADME R-HSA-9754706 8.624092e-01 0.064 0 0
Activation of SMO R-HSA-5635838 8.624092e-01 0.064 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.624092e-01 0.064 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.624092e-01 0.064 0 0
Attachment and Entry R-HSA-9678110 8.624092e-01 0.064 0 0
Virus Assembly and Release R-HSA-168268 8.624092e-01 0.064 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.631275e-01 0.064 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 8.697824e-01 0.061 0 0
PI Metabolism R-HSA-1483255 8.701257e-01 0.060 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 8.701571e-01 0.060 0 0
Transcription of the HIV genome R-HSA-167172 8.708901e-01 0.060 0 0
DAP12 signaling R-HSA-2424491 8.714188e-01 0.060 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.714188e-01 0.060 0 0
Neurotransmitter clearance R-HSA-112311 8.714188e-01 0.060 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.714188e-01 0.060 0 0
SLC transporter disorders R-HSA-5619102 8.751387e-01 0.058 0 0
Scavenging by Class B Receptors R-HSA-3000471 8.754078e-01 0.058 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 8.754078e-01 0.058 0 0
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-HSA-77346 8.754078e-01 0.058 0 0
Synthesis of PG R-HSA-1483148 8.754078e-01 0.058 0 0
Galactose catabolism R-HSA-70370 8.754078e-01 0.058 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 8.754078e-01 0.058 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 8.754078e-01 0.058 0 0
Coenzyme A biosynthesis R-HSA-196783 8.754078e-01 0.058 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.773951e-01 0.057 0 0
Neuronal System R-HSA-112316 8.793111e-01 0.056 0 0
Leishmania infection R-HSA-9658195 8.818166e-01 0.055 0 0
Parasitic Infection Pathways R-HSA-9824443 8.818166e-01 0.055 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 8.871791e-01 0.052 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.871791e-01 0.052 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 8.871791e-01 0.052 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 8.871791e-01 0.052 0 0
Choline catabolism R-HSA-6798163 8.871791e-01 0.052 0 0
Surfactant metabolism R-HSA-5683826 8.881109e-01 0.052 0 0
Signaling by WNT in cancer R-HSA-4791275 8.900003e-01 0.051 0 0
Platelet homeostasis R-HSA-418346 8.971632e-01 0.047 0 0
Transport of connexons to the plasma membrane R-HSA-190872 8.978389e-01 0.047 0 0
FGFR1 ligand binding and activation R-HSA-190242 8.978389e-01 0.047 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 8.978389e-01 0.047 0 0
Tie2 Signaling R-HSA-210993 8.978389e-01 0.047 0 0
Triglyceride metabolism R-HSA-8979227 8.979433e-01 0.047 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 8.983262e-01 0.047 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.024178e-01 0.045 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.024178e-01 0.045 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.025358e-01 0.045 0 0
GABA receptor activation R-HSA-977443 9.040867e-01 0.044 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.043786e-01 0.044 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.060616e-01 0.043 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 9.060616e-01 0.043 0 0
HDL remodeling R-HSA-8964058 9.074921e-01 0.042 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.074921e-01 0.042 0 0
Germ layer formation at gastrulation R-HSA-9754189 9.074921e-01 0.042 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 9.074921e-01 0.042 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.074921e-01 0.042 0 0
Maturation of nucleoprotein R-HSA-9694631 9.074921e-01 0.042 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.074921e-01 0.042 0 0
Other interleukin signaling R-HSA-449836 9.074921e-01 0.042 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.132435e-01 0.039 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.136591e-01 0.039 0 0
Metal ion SLC transporters R-HSA-425410 9.150513e-01 0.039 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.153985e-01 0.038 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.162337e-01 0.038 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.162337e-01 0.038 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.162337e-01 0.038 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.199076e-01 0.036 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.207927e-01 0.036 0 0
Signalling to RAS R-HSA-167044 9.241497e-01 0.034 0 0
Abacavir metabolism R-HSA-2161541 9.241497e-01 0.034 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.241497e-01 0.034 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.241497e-01 0.034 0 0
Ion transport by P-type ATPases R-HSA-936837 9.255033e-01 0.034 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.261772e-01 0.033 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.272034e-01 0.033 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.313181e-01 0.031 0 0
Ribavirin ADME R-HSA-9755088 9.313181e-01 0.031 0 0
Glutathione synthesis and recycling R-HSA-174403 9.313181e-01 0.031 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.313181e-01 0.031 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.313181e-01 0.031 0 0
Attachment and Entry R-HSA-9694614 9.313181e-01 0.031 0 0
Metabolism of proteins R-HSA-392499 9.335783e-01 0.030 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.378093e-01 0.028 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.378093e-01 0.028 0 0
Fructose metabolism R-HSA-5652084 9.378093e-01 0.028 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.378093e-01 0.028 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.378093e-01 0.028 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.391127e-01 0.027 0 0
RSV-host interactions R-HSA-9833110 9.402776e-01 0.027 0 0
Gastrulation R-HSA-9758941 9.405028e-01 0.027 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.412720e-01 0.026 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.412720e-01 0.026 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 9.420331e-01 0.026 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.436875e-01 0.025 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.436875e-01 0.025 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.436875e-01 0.025 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.436875e-01 0.025 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.436875e-01 0.025 0 0
Biosynthesis of maresins R-HSA-9018682 9.436875e-01 0.025 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.461537e-01 0.024 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.465789e-01 0.024 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 9.465789e-01 0.024 0 0
HIV Transcription Elongation R-HSA-167169 9.465789e-01 0.024 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 9.465789e-01 0.024 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.472121e-01 0.024 0 0
Leishmania phagocytosis R-HSA-9664417 9.472121e-01 0.024 0 0
Parasite infection R-HSA-9664407 9.472121e-01 0.024 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.490103e-01 0.023 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.490103e-01 0.023 0 0
Complex III assembly R-HSA-9865881 9.490103e-01 0.023 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.496176e-01 0.022 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.507837e-01 0.022 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.538303e-01 0.021 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.538303e-01 0.021 0 0
Fertilization R-HSA-1187000 9.538303e-01 0.021 0 0
Laminin interactions R-HSA-3000157 9.538303e-01 0.021 0 0
HIV Transcription Initiation R-HSA-167161 9.546712e-01 0.020 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.546712e-01 0.020 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.546712e-01 0.020 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.546712e-01 0.020 0 0
Dectin-2 family R-HSA-5621480 9.553899e-01 0.020 0 0
MET activates PTK2 signaling R-HSA-8874081 9.581950e-01 0.019 0 0
TRP channels R-HSA-3295583 9.581950e-01 0.019 0 0
Urea cycle R-HSA-70635 9.581950e-01 0.019 0 0
Sphingolipid catabolism R-HSA-9845614 9.581950e-01 0.019 0 0
Abacavir ADME R-HSA-2161522 9.581950e-01 0.019 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.581950e-01 0.019 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.581950e-01 0.019 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.585470e-01 0.018 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.585470e-01 0.018 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.586209e-01 0.018 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.614935e-01 0.017 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.615827e-01 0.017 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.615827e-01 0.017 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 9.621472e-01 0.017 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 9.621472e-01 0.017 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.621472e-01 0.017 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.621472e-01 0.017 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.642422e-01 0.016 0 0
DAP12 interactions R-HSA-2172127 9.646472e-01 0.016 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.646472e-01 0.016 0 0
HIV elongation arrest and recovery R-HSA-167287 9.657260e-01 0.015 0 0
Pausing and recovery of HIV elongation R-HSA-167290 9.657260e-01 0.015 0 0
Insulin receptor recycling R-HSA-77387 9.657260e-01 0.015 0 0
Pyrimidine salvage R-HSA-73614 9.657260e-01 0.015 0 0
Prednisone ADME R-HSA-9757110 9.657260e-01 0.015 0 0
Collagen degradation R-HSA-1442490 9.668053e-01 0.015 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.673630e-01 0.014 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.674760e-01 0.014 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.676056e-01 0.014 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.684761e-01 0.014 0 0
Thyroxine biosynthesis R-HSA-209968 9.689667e-01 0.014 0 0
Platelet calcium homeostasis R-HSA-418360 9.689667e-01 0.014 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.689667e-01 0.014 0 0
Integrin cell surface interactions R-HSA-216083 9.706814e-01 0.013 0 0
Cholesterol biosynthesis R-HSA-191273 9.706814e-01 0.013 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.719011e-01 0.012 0 0
Synthesis of PC R-HSA-1483191 9.724936e-01 0.012 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.738865e-01 0.011 0 0
Peptide hormone metabolism R-HSA-2980736 9.742979e-01 0.011 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.745582e-01 0.011 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.747848e-01 0.011 0 0
PPARA activates gene expression R-HSA-1989781 9.763395e-01 0.010 0 0
Collagen formation R-HSA-1474290 9.763774e-01 0.010 0 0
Azathioprine ADME R-HSA-9748787 9.786452e-01 0.009 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.786747e-01 0.009 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.786954e-01 0.009 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.788879e-01 0.009 0 0
Metabolism of steroid hormones R-HSA-196071 9.788879e-01 0.009 0 0
G alpha (s) signalling events R-HSA-418555 9.805475e-01 0.009 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.806099e-01 0.009 0 0
Potassium Channels R-HSA-1296071 9.806099e-01 0.009 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.811154e-01 0.008 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.821558e-01 0.008 0 0
Gap junction assembly R-HSA-190861 9.829016e-01 0.007 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.829016e-01 0.007 0 0
Formation of the cornified envelope R-HSA-6809371 9.830361e-01 0.007 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.845190e-01 0.007 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.845190e-01 0.007 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.845190e-01 0.007 0 0
Purine catabolism R-HSA-74259 9.856291e-01 0.006 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.859834e-01 0.006 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.859834e-01 0.006 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.859834e-01 0.006 0 0
Paracetamol ADME R-HSA-9753281 9.860565e-01 0.006 0 0
Extracellular matrix organization R-HSA-1474244 9.868160e-01 0.006 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.872036e-01 0.006 0 0
Voltage gated Potassium channels R-HSA-1296072 9.873094e-01 0.006 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.873094e-01 0.006 0 0
Collagen chain trimerization R-HSA-8948216 9.873094e-01 0.006 0 0
Synthesis of PA R-HSA-1483166 9.882586e-01 0.005 0 0
Neurotransmitter release cycle R-HSA-112310 9.883247e-01 0.005 0 0
Elastic fibre formation R-HSA-1566948 9.885100e-01 0.005 0 0
Purine salvage R-HSA-74217 9.885100e-01 0.005 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.885100e-01 0.005 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.902773e-01 0.004 0 0
Tryptophan catabolism R-HSA-71240 9.905814e-01 0.004 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.905814e-01 0.004 0 0
Maturation of spike protein R-HSA-9694548 9.914727e-01 0.004 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.914727e-01 0.004 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.918279e-01 0.004 0 0
Visual phototransduction R-HSA-2187338 9.921540e-01 0.003 0 0
Intra-Golgi traffic R-HSA-6811438 9.922796e-01 0.003 0 0
G alpha (i) signalling events R-HSA-418594 9.929007e-01 0.003 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.930102e-01 0.003 0 0
Defensins R-HSA-1461973 9.936718e-01 0.003 0 0
Methylation R-HSA-156581 9.942707e-01 0.002 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.946291e-01 0.002 0 0
mitochondrial fatty acid beta-oxidation of saturated fatty acids R-HSA-77286 9.948130e-01 0.002 0 0
Kidney development R-HSA-9830369 9.950800e-01 0.002 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.956203e-01 0.002 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.957468e-01 0.002 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.961510e-01 0.002 0 0
COPII-mediated vesicle transport R-HSA-204005 9.962213e-01 0.002 0 0
Retinoid metabolism and transport R-HSA-975634 9.965404e-01 0.002 0 0
Metabolism of cofactors R-HSA-8978934 9.965404e-01 0.002 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.968331e-01 0.001 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.969355e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.971440e-01 0.001 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.971440e-01 0.001 0 0
G alpha (q) signalling events R-HSA-416476 9.976395e-01 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 9.976593e-01 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 9.981413e-01 0.001 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.982196e-01 0.001 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.982634e-01 0.001 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.983577e-01 0.001 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.985783e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.987945e-01 0.001 0 0
Glutathione conjugation R-HSA-156590 9.988337e-01 0.001 0 0
Nucleotide salvage R-HSA-8956321 9.989442e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.990723e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.991017e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.991235e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.991348e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.992168e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.992792e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.994741e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.994741e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.995546e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.995979e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.996099e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.996099e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.996648e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.996804e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.997107e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.997206e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.997381e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.997414e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.997672e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.998058e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.998170e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.998242e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.998242e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.998436e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.998517e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.998527e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.998560e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999208e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999226e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999293e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999356e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.999414e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999597e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999736e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999771e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999880e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999914e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999956e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999959e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999966e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999967e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999984e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999988e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999988e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999992e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999994e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999996e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999998e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999998e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.999999e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999999e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways