MARK1

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

Log-Odds: S Sites / S Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
O00267	S804	Sugiyama	SUPT5H SPT5 SPT5H	tPMYGsQtPLQDGsRtPHyGsQtPLHDGsRtPAQsGAWDPN
O00410	S726	Sugiyama	IPO5 KPNB3 RANBP5	LMVPLLKFYFHDGVRVAAAEsMPLLLECARVRGPEYLTQMW
O00468	S641	Sugiyama	AGRN AGRIN	PRCEHPPPGPVCGSDGVTyGsACELREAACLQQtQIEEARA
O00541	S282	Sugiyama	PES1	EGTyALDSESCMEKLAALsAsLARVVVPATEEEAEVDEFPt
O14974	S910	Sugiyama	PPP1R12A MBS MYPT1	yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O14980	S1055	Sugiyama	XPO1 CRM1	LEEREIALRQADEEKHKRQMsVPGIFNPHEIPEEMCD____
O15013	S1282	Sugiyama	ARHGEF10 KIAA0294	PDAAIWLGDSLGSMTQKsDLssssGsLsLsHGsssLEHRSE
O15226	S618	Sugiyama	NKRF ITBA4 NRF	VNKIAKRDIEQIIRNYARsEsHtDLtFsRELTNDERKQIHQ
O15355	S349	Sugiyama	PPM1G PPM1C	tTAVVALIRGKQLIVANAGDsRCVVsEAGKALDMsyDHKPE
O15460	S531	Sugiyama	P4HA2 UNQ290/PRO330	KWVSNKWFHERGQEFLRPCGstEVD________________
O43290	S378	Sugiyama	SART1	DGLRERELEEIRAKLRLQAQsLSTVGPRLASEYLtPEEMVT
O43290	S624	Sugiyama	SART1	IGWSTVNLDEEKQQQDFSASsTtILDEEPIVNRGLAAALLL
O43318	S439	Sugiyama	MAP3K7 TAK1	GNILDVPEIVISGNGQPRRRsIQDLtVtGTEPGQVssRsss
O43399	S96	Sugiyama	TPD52L2	ELKRRLGLstLGELKQNLsRsWHDVQVssAyVKTSEKLGEW
O43707	S763	Sugiyama	ACTN4	IARTINEVENQILtRDAKGIsQEQMQEFRASFNHFDKDHGG
O43815	S227	Sugiyama	STRN	NGTEAEVKETAMIAKSELtDsAsVLDNFKFLEsAAADFsDE
O43823	S323	Sugiyama	AKAP8 AKAP95	RKRKQFQLyEEPDtKLARVDsEGDFsENDDAAGDFRsGDEE
O43852	S69	Sugiyama	CALU	HDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKDGFVt
O60291	S515	Sugiyama	MGRN1 KIAA0544 RNF156	sFItEEVDESssPQQGTRAAsIENVLQDssPEHCGRGPPAD
O60333	S1057	Sugiyama	KIF1B KIAA0591 KIAA1448	DNEYFNQSDFSSVAMTRsGLsLEELRIVEGQGQSSEVItPP
O60664	S179	Sugiyama	PLIN3 M6PRBP1 TIP47	QSGVDKTKsVVtGGVQsVMGsRLGQMVLsGVDtVLGKsEEW
O60749	S119	Sugiyama	SNX2 TRG9	AVtPVtPttLIAPRIESKsMsAPVIFDRsREEIEEEANGDI
O60763	S32	Sugiyama	USO1 VDP	SAGPQHTEAEtIQKLCDRVAssTLLDDRRNAVRALKSLSKK
O60841	S186	Sugiyama	EIF5B IF2 KIAA0741	EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O75390	S453	Sugiyama	CS	LAQLIWSRALGFPLERPKSMsTEGLMKFVDSKSG_______
O75822	S127	Sugiyama	EIF3J EIF3S1 PRO0391	VLtPEEQLADKLRLKKLQEEsDLELAKEtFGVNNAVyGIDA
O94776	S54	Sugiyama	MTA2 MTA1L1 PID	ANGNVEAKVVCLFRRRDIsssLNSLADSNAREFEEESKQPG
O95155	S105	Sugiyama	UBE4B HDNB1 KIAA0684 UFD2	LsssPsNsLEtQsQsLsRsQsMDIDGVSCEKsMsQVDVDsG
O95218	S181	Sugiyama	ZRANB2 ZIS ZNF265	DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
O95376	S113	Sugiyama	ARIH2 ARI2 TRIAD1 HT005	LILVNFHWQVSEILDRYKSNsAQLLVEARVQPNPSKHVPTS
O95757	S599	Sugiyama	HSPA4L APG1 HSPH3 OSP94	sIDLPIQssLCRQLGQDLLNsyIENEGKMIMQDKLEKERND
O95819	S800	Sugiyama	MAP4K4 HGK KIAA0687 NIK	DVEQEGADESTSGPEDTRAAsSLNLSNGETESVKTMIVHDD
P00338	S105	Sugiyama	LDHA PIG19	VTANsKLVIItAGARQQEGEsRLNLVQRNVNIFKFIIPNVV
P00338	S161	Sugiyama	LDHA PIG19	DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00491	S176	Sugiyama	PNP NP	GDRFPAMsDAyDRtMRQRALstWKQMGEQRELQEGTYVMVA
P00558	S174	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	LSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKEL
P00558	S175	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	SKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKELN
P02545	S295	Sugiyama	LMNA LMN1	RQsAERNsNLVGAAHEELQQsRIRIDsLsAQLsQLQKQLAA
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04083	S201	Sugiyama	ANXA1 ANX1 LPC1	LsLAKGDRsEDFGVNEDLADsDARALyEAGERRKGtDVNVF
P04406	S241	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406	T237	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792	S78	Sugiyama	HSPB1 HSP27 HSP28	LPPAAIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVs
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05023	S520	Sugiyama	ATP1A1	EPQHLLVMKGAPERILDRCssILLHGKEQPLDEELKDAFQN
P05198	S219	Sugiyama	EIF2S1 EIF2A	CYGYEGIDAVKEALRAGLNCsTENMPIKINLIAPPRYVMTT
P06280	S176	Sugiyama	GLA	AQTFADWGVDLLKFDGCYCDsLENLADGYKHMSLALNRTGR
P06733	S27	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P07195	S106	Sugiyama	LDHB	VtANSKIVVVtAGVRQQEGEsRLNLVQRNVNVFKFIIPQIV
P07195	S162	Sugiyama	LDHB	DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195	S303	Sugiyama	LDHB	GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195	S320	Sugiyama	LDHB	GLtsVINQKLKDDEVAQLKKsADtLWDIQKDLKDL______
P07195	S44	Sugiyama	LDHB	ITVVGVGQVGMACAISILGKsLADELALVDVLEDKLKGEMM
P07195	T323	Sugiyama	LDHB	sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07339	S42	Sugiyama	CTSD CPSD	VRIPLHKFTSIRRtMsEVGGsVEDLIAKGPVSKYSQAVPAV
P07384	S474	Sugiyama	CAPN1 CANPL1 PIG30	GQPAVHLKRDFFLANAsRARsEQFINLREVSTRFRLPPGEY
P07437	S40	Sugiyama	TUBB TUBB5 OK/SW-cl.56	FWEVISDEHGIDPTGtyHGDsDLQLDRIsVyyNEAtGGKyV
P07737	S30	Sugiyama	PFN1	NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07814	S335	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	PIEKNLQMWEEMKKGsQFGQsCCLRAKIDMSSNNGCMRDPt
P07814	S747	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	ETSAPFKERPtPsLNNNCttsEDsLVLyNRVAVQGDVVREL
P07864	S161	Sugiyama	LDHC LDH3 LDHX	DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900	S164	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	VAEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGT
P07900	S399	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNLVKK
P07900	S52	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900	S53	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P08238	S159	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	VAEKVVVITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGT
P08238	S391	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNIVKK
P08238	S462	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238	S48	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P09923	S189	Sugiyama	ALPI	RVQHAsPAGtyAHtVNRNWysDADMPASARQEGCQDIATQL
P0CAP2	S187	Sugiyama	POLR2M GRINL1A	EASEHHPRHRVssQAEDtSssFDNLFIDRLQRITIADQGEQ
P10398	S157	Sugiyama	ARAF ARAF1 PKS PKS2	SSKVPTVCVDMSTNRQQFyHsVQDLsGGsRQHEAPsNRPLN
P10636	S235	iPTMNet\|EPSD	MAPT MAPTL MTBT1 TAU	KEEVDEDRDVDESsPQDsPPsKAsPAQDGRPPQTAAREATS
P10636	S579	GPS6\|SIGNOR\|EPSD	MAPT MAPTL MTBT1 TAU	RLQTAPVPMPDLKNVKsKIGstENLKHQPGGGKVQIINKKL
P10636	S610	GPS6\|EPSD	MAPT MAPTL MTBT1 TAU	GKVQIINKKLDLsNVQsKCGsKDNIKHVPGGGsVQIVyKPV
P10636	S622	GPS6\|EPSD	MAPT MAPTL MTBT1 TAU	sNVQsKCGsKDNIKHVPGGGsVQIVyKPVDLSKVTsKCGsL
P10636	S637	SIGNOR	MAPT MAPTL MTBT1 TAU	VPGGGsVQIVyKPVDLSKVTsKCGsLGNIHHKPGGGQVEVK
P10636	S641	GPS6\|SIGNOR\|EPSD	MAPT MAPTL MTBT1 TAU	GsVQIVyKPVDLSKVTsKCGsLGNIHHKPGGGQVEVKSEKL
P10636	S673	GPS6\|SIGNOR\|EPSD	MAPT MAPTL MTBT1 TAU	QVEVKSEKLDFKDRVQsKIGsLDNITHVPGGGNKKIEtHKL
P10809	S488	Sugiyama	HSPD1 HSP60	IKRTLKIPAMtIAKNAGVEGsLIVEKIMQSSsEVGYDAMAG
P11137	S1540	SIGNOR\|EPSD	MAP2	FKQAKDKVSDGVtKsPEKRssLPRPSSILPPRRGVsGDRDE
P11137	S1679	SIGNOR\|EPSD	MAP2	QLRLINQPLPDLKNVKsKIGsTDNIKYQPKGGQVQIVTKKI
P11137	S1710	SIGNOR\|EPSD	MAP2	GQVQIVTKKIDLSHVTSKCGsLKNIRHRPGGGRVKIESVKL
P11137	S1795	SIGNOR\|EPSD	MAP2	GAEIItQsPGRssVAsPRRLsNVsssGsINLLEsPQLATLA
P11137	S1799	SIGNOR\|EPSD	MAP2	ItQsPGRssVAsPRRLsNVsssGsINLLEsPQLATLAEDVT
P11137	S1802	SIGNOR\|EPSD	MAP2	sPGRssVAsPRRLsNVsssGsINLLEsPQLATLAEDVTAAL
P11137	S385	iPTMNet	MAP2	SFKIEEPHEAKPDKMAEAPPsEAMTLPKDAHIPVVEEHVMG
P11142	S40	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142	T163	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11279	S141	Sugiyama	LAMP1	NLSDTHLFPNASSKEIKtVEsITDIRADIDKKYRCVSGTQV
P11586	S765	Sugiyama	MTHFD1 MTHFC MTHFD	ARMFGIPVVVAVNAFKTDTEsELDLIsRLSREHGAFDAVKC
P12268	S416	Sugiyama	IMPDH2 IMPD2	APGEYFFSDGIRLKKyRGMGsLDAMDKHLssQNRyFsEADK
P12814	S744	Sugiyama	ACTN1	IARTINEVENQILtRDAKGIsQEQMNEFRAsFNHFDRDHsG
P13473	S155	Sugiyama	LAMP2	LTVDELLAIRIPLNDLFRCNsLSTLEKNDVVQHYWDVLVQA
P13489	S178	Sugiyama	RNH1 PRI RNH	SCEPLASVLRAKPDFKELtVsNNDINEAGVRVLCQGLKDSP
P13489	S225	Sugiyama	RNH1 PRI RNH	KLEsCGVTSDNCRDLCGIVAsKASLRELALGSNKLGDVGMA
P13639	S38	Sugiyama	EEF2 EF2	NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13639	S732	Sugiyama	EEF2 EF2	DAIHRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQCP
P13667	S470	Sugiyama	PDIA4 ERP70 ERP72	FAIADEEDyAGEVKDLGLsEsGEDVNAAILDEsGKKFAMEP
P13797	S540	Sugiyama	PLS3	NDDIIVNWVNRTLSEAGKSTsIQSFKDKTISSSLAVVDLID
P13798	S187	Sugiyama	APEH D3F15S2 D3S48E DNF15S2	EKKRPKAEsFFQTKALDVsAsDDEIARLKKPDQAIKGDQFV
P13798	S27	Sugiyama	APEH D3F15S2 D3S48E DNF15S2	LsEPEEAAALyRGLSRQPALsAACLGPEVtTQyGGQyRTVH
P14314	S108	Sugiyama	PRKCSH G19P1	PSNRVNDGVCDCCDGtDEyNsGVICENtCKEKGRKEREsLQ
P14314	S126	Sugiyama	PRKCSH G19P1	yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14618	S205	Sugiyama	PKM OIP3 PK2 PK3 PKM2	VKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVsEKD
P14625	S109	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P14625	S447	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	PKyLNFVKGVVDsDDLPLNVsREtLQQHKLLKVIRKKLVRK
P14625	T171	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	GVGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSEL
P15311	S535	Sugiyama	EZR VIL2	EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15531	S122	Sugiyama	NME1 NDPKA NM23	GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P16949	S46	Sugiyama	STMN1 C1orf215 LAP18 OP18	PRsKEsVPEFPLsPPKKKDLsLEEIQKKLEAAEERRKsHEA
P17066	S42	Sugiyama	HSPA6 HSP70B'	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17987	S374	Sugiyama	TCP1 CCT1 CCTA	ERICDDELILIKNTKARTsAsIILRGANDFMCDEMERSLHD
P17987	S544	Sugiyama	TCP1 CCT1 CCTA	ILRIDDLIKLHPESKDDKHGsyEDAVHsGALND________
P18206	S809	Sugiyama	VCL	ELsKtIsPMVMDAKAVAGNIsDPGLQKsFLDsGyRILGAVA
P18615	S115	Sugiyama	NELFE RD RDBP	KLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLyEs
P18669	S14	Sugiyama	PGAM1 PGAMA CDABP0006	_______MAAYKLVLIRHGEsAWNLENRFsGWyDADLsPAG
P18669	S152	Sugiyama	PGAM1 PGAMA CDABP0006	FysNIsKDRRyADLtEDQLPsCEsLKDtIARALPFWNEEIV
P19338	S328	Sugiyama	NCL	NLFVGNLNFNKSAPELKtGIsDVFAKNDLAVVDVRIGMTRK
P19338	S356	Sugiyama	NCL	LAVVDVRIGMTRKFGyVDFEsAEDLEKALELtGLKVFGNEI
P19338	S460	Sugiyama	NCL	ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P20618	Y158	Sugiyama	PSMB1 PSC5	IGGLDEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLLD
P20674	S104	Sugiyama	COX5A	PEPKIIDAALRACRRLNDFAstVRILEVVKDKAGPHKEIYP
P21108	S11	Sugiyama	PRPS1L1 PRPS3 PRPSL	__________MPNIKIFsGssHQDLSQKIADRLGLELGKVV
P21333	S2152	Sugiyama	FLNA FLN FLN1	VKVTGEGRVKEsITRRRRAPsVANVGsHCDLsLKIPEIsIQ
P21333	S2158	Sugiyama	FLNA FLN FLN1	GRVKEsITRRRRAPsVANVGsHCDLsLKIPEIsIQDMtAQV
P22059	S386	Sugiyama	OSBP OSBP1	ITMPENLGHKRtGsNIsGAssDIsLDEQyKHQLEETKKEKR
P22090	S204	Sugiyama	RPS4Y1 RPS4Y PRO2646	IGGANLGRVGVITNRERHPGsFDVVHVKDANGNSFATRLSN
P22314	S46	Sugiyama	UBA1 A1S9T UBE1	AQsVLsEVPSVPTNGMAKNGsEADIDEGLysRQLyVLGHEA
P22626	S189	Sugiyama	HNRNPA2B1 HNRPA2B1	IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P23284	S150	Sugiyama	PPIB CYPB	LKHyGPGWVsMANAGKDTNGsQFFITTVKTAWLDGKHVVFG
P23588	S122	Sugiyama	EIF4B	NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P24534	S174	Sugiyama	EEF1B2 EEF1B EF1B	DMAKLEECVRsIQADGLVWGssKLVPVGyGIKKLQIQCVVE
P25054	S1389	Sugiyama	APC DP2.5	PKsPPEHYVQETPLMFsRCTsVSsLDSFESRSIASSVQSEP
P25054	S1861	Sugiyama	APC DP2.5	DsPHHytPIEGTPYCFsRNDsLssLDFDDDDVDLSREKAEL
P26232	S667	Sugiyama	CTNNA2 CAPR	YDVRsRtsVQtEDDQLIAGQsARAIMAQLPQEEKAKIAEQV
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373	T107	Sugiyama	RPL13 BBC1 OK/SW-cl.46	HKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILF
P27448	S96	Sugiyama	MARK3 CTAK1 EMK2	ILTGREVAIKIIDKtQLNPtsLQKLFREVRIMKILNHPNIV
P27797	S52	Sugiyama	CALR CRTC	GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27816	S1073	SIGNOR\|ELM\|iPTMNet\|EPSD	MAP4	DVKIEsQKLNFKEKAQAKVGsLDNVGHLPAGGAVKTEGGGS
P27816	S928	SIGNOR\|iPTMNet\|EPSD	MAP4	PTSAKPssttPRLSRLAtNtsAPDLKNVRsKVGstENIKHQ
P27816	S941	SIGNOR\|ELM\|iPTMNet\|EPSD	MAP4	SRLAtNtsAPDLKNVRsKVGstENIKHQPGGGRAKVEKKTE
P28066	S180	Sugiyama	PSMA5	GtFVQCDARAIGsAsEGAQssLQEVyHKSMTLKEAIKSSLI
P28838	S180	Sugiyama	LAP3 LAPEP PEPS	YEYDDLKQKKKMAVSAKLyGsGDQEAWQKGVLFAsGQNLAR
P28838	S194	Sugiyama	LAP3 LAPEP PEPS	SAKLyGsGDQEAWQKGVLFAsGQNLARQLMETPANEMTPtR
P29144	S176	Sugiyama	TPP2	FDVANNGSsQANKLIKEELQsQVELLNsFEKKYSDPGPVYD
P30050	S138	Sugiyama	RPL12	HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30086	S54	Sugiyama	PEBP1 PBP PEBP	VDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPDAP
P30622	S195	Sugiyama	CLIP1 CYLN1 RSN	AAKEPsAtPPISNLTKtAsEsIsNLsEAGsIKKGERELKIG
P31327	S537	Sugiyama	CPS1	GVELFKRGVLKEYGVKVLGtsVEsIMATEDRQLFSDKLNEI
P31327	S835	Sugiyama	CPS1	MCHPsIEGFTPRLPMNKEWPsNLDLRKELSEPSsTRIyAIA
P34897	S90	Sugiyama	SHMT2	GLELIAsENFCsRAALEALGsCLNNKYSEGYPGKRyyGGAE
P34931	S42	Sugiyama	HSPA1L	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34932	T364	Sugiyama	HSPA4 APG2 HSPH2	ATRIPAVKEKISKFFGKELsttLNADEAVTRGCALQCAILs
P35221	S668	Sugiyama	CTNNA1	FDVRsRtsVQtEDDQLIAGQsARAIMAQLPQEQKAKIAEQV
P35241	S533	Sugiyama	RDX	ERVTETQKNERVKKQLQALssELAQARDETKKTQNDVLHAE
P35606	S350	Sugiyama	COPB2	MGDAEIKDGERLPLAVKDMGsCEIyPQtIQHNPNGRFVVVC
P35613	S228	Sugiyama	BSG UNQ6505/PRO21383	EPMGTANIQLHGPPRVKAVKssEHINEGEtAMLVCKSEsVP
P37802	S163	Sugiyama	TAGLN2 KIAA0120 CDABP0035	LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802	S185	Sugiyama	TAGLN2 KIAA0120 CDABP0035	NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P38646	S89	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646	T398	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39748	S255	Sugiyama	FEN1 RAD2	CESIRGIGPKRAVDLIQKHKsIEEIVRRLDPNKYPVPENWL
P40818	S718	Sugiyama	USP8 KIAA0055 UBPY	AKPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtP
P43034	S152	Sugiyama	PAFAH1B1 LIS1 MDCR MDS PAFAHA	IKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADM
P43487	S60	Sugiyama	RANBP1	TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P43490	S472	Sugiyama	NAMPT PBEF PBEF1	EYGQDLLHTVFKNGKVTKsysFDEIRKNAQLNIELEAAHH_
P46013	S1098	Sugiyama	MKI67	PAARVTGMKKWPRtPKEEAQsLEDLAGFKELFQtPGPsEEs
P46013	S651	Sugiyama	MKI67	ISRsQHDILQMICSKRRsGAsEANLIVAKSWADVVKLGAKQ
P46776	S68	Sugiyama	RPL27A	yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777	S176	Sugiyama	RPL5 MSTP030	GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P46777	S224	Sugiyama	RPL5 MSTP030	VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46783	S146	Sugiyama	RPS10	TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P46940	S1448	Sugiyama	IQGAP1 KIAA0051	AIRDAKTPDKMKKsKsVKEDsNLtLQEKKEKIQTGLKKLTE
P46940	S482	Sugiyama	IQGAP1 KIAA0051	LINRALESGDVNTVWKQLsssVtGLTNIEEENCQRYLDELM
P47756	S192	Sugiyama	CAPZB	TVMLWLQTNKSGsGtMNLGGsLtRQMEKDEtVsDCsPHIAN
P48741	S42	Sugiyama	HSPA7 HSP70B	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49321	S662	Sugiyama	NASP	LKELLPEIREKIEDAKEsQRsGNVAELALKATLVEsstsGF
P49327	S265	Sugiyama	FASN FAS	TILNAGTNTDGFKEQGVtFPsGDIQEQLIRSLyQsAGVAPE
P49368	S458	Sugiyama	CCT3 CCTG TRIC5	RAVAQALEVIPRTLIQNCGAstIRLLtSLRAKHtQENCEtW
P49588	S775	Sugiyama	AARS1 AARS	VTGAEAQKALRKAESLKKCLsVMEAKVKAQTAPNKDVQREI
P49736	S170	Sugiyama	MCM2 BM28 CCNL1 CDCL1 KIAA0030	KRRQVERAtEDGEEDEEMIEsIENLEDLKGHSVREWVsMAG
P49790	S607	Sugiyama	NUP153	KtPPEDCEGPFRPAEILKEGsVLDILKsPGFAsPKIDSVAA
P50395	S396	Sugiyama	GDI2 RABGDIB	IEQKFVsISDLLVPKDLGtEsQIFIsRTyDAttHFEttCDD
P50395	S427	Sugiyama	GDI2 RABGDIB	ttHFEttCDDIKNIYKRMtGsEFDFEEMKRKKNDIYGED__
P50402	S29	Sugiyama	EMD EDMD STA	DtELttLLRRyNIPHGPVVGstRRLyEKKIFEyEtQRRRLs
P51946	S15	Sugiyama	CCNH	______MYHNsSQKRHWtFSsEEQLARLRADANRKFRCKAV
P52298	S13	Sugiyama	NCBP2 CBP20 PIG55	________MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQE
P52597	S187	Sugiyama	HNRNPF HNRPF	KALGKHKERIGHRYIEVFKssQEEVRsysDPPLKFMsVQRP
P52597	S63	Sugiyama	HNRNPF HNRPF	VHFIYTREGRQsGEAFVELGsEDDVKMALKKDRESMGHRyI
P53621	S389	Sugiyama	COPA	SYNPAENAVLLCTRAsNLENstyDLytIPKDADsQNPDAPE
P53999	S56	Sugiyama	SUB1 PC4 RPO2TC1	PVKKQKTGETsRALsssKQssssRDDNMFQIGKMRYVSVRD
P53999	S58	Sugiyama	SUB1 PC4 RPO2TC1	KKQKTGETsRALsssKQssssRDDNMFQIGKMRYVSVRDFK
P54105	S42	Sugiyama	CLNS1A CLCI ICLN	DTEAVLNGKGLGtGtLyIAEsRLSWLDGsGLGFSLEYPTIS
P54252	S260	Sugiyama	ATXN3 ATX3 MJD MJD1 SCA3	IDMEDEEADLRRAIQLsMQGssRNIsQDMtQtsGTNLTSEE
P54652	S41	Sugiyama	HSPA2	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P55036	S266	Sugiyama	PSMD4 MCB1	AGIATTGtEDsDDALLKMtIsQQEFGRTGLPDLSSMTEEEQ
P55060	S931	Sugiyama	CSE1L CAS XPO2	KKEHDPVGQMVNNPKIHLAQsLHKLSTACPGRVPSMVSTSL
P55769	S122	Sugiyama	SNU13 NHP2L1	CSVTIKEGSQLKQQIQsIQQsIERLLV______________
P55957	S78	Sugiyama	BID	QtDGNRssHsRLGRIEADsEsQEDIIRNIARHLAQVGDsMD
P60174	S212	Sugiyama	TPI1 TPI	WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709	S323	Sugiyama	ACTB	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709	T324	Sugiyama	ACTB	tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P60891	S11	Sugiyama	PRPS1	__________MPNIKIFsGssHQDLSQKIADRLGLELGKVV
P61081	S175	Sugiyama	UBE2M UBC12	NNRRLFEQNVQRSMRGGyIGstyFERCLK____________
P61163	T248	Sugiyama	ACTR1A CTRN1	PQKDETLETEKAQyyLPDGstIEIGPSRFRAPELLFRPDLI
P61313	S97	Sugiyama	RPL15 EC45 TCBAP0781	KGAtyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLN
P61326	S106	Sugiyama	MAGOH MAGOHA	QELEIVIGDEHISFTTSKIGsLIDVNQSKDPEGLRVFYYLV
P61916	S29	Sugiyama	NPC2 HE1	LLLALSTAAQAEPVQFKDCGsVDGVIKEVNVsPCPtQPCQL
P61978	S401	Sugiyama	HNRNPK HNRPK	GDLGGPIIttQVtIPKDLAGsIIGKGGQRIKQIRHEsGAsI
P61978	S75	Sugiyama	HNRNPK HNRPK	GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P62241	S115	Sugiyama	RPS8 OK/SW-cl.83	TLVKNCIVLIDStPYRQWyEsHyALPLGRKKGAKLtPEEEE
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62273	Y7	Sugiyama	RPS29	______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277	S12	Sugiyama	RPS13	_________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62701	S204	Sugiyama	RPS4X CCG2 RPS4 SCAR	tGGANLGRIGVITNRERHPGsFDVVHVKDANGNSFATRLsN
P62736	S325	Sugiyama	ACTA2 ACTSA ACTVS GIG46	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736	T326	Sugiyama	ACTA2 ACTSA ACTVS GIG46	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P63104	S28	Sugiyama	YWHAZ	QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104	S57	Sugiyama	YWHAZ	sNEERNLLsVAyKNVVGARRssWRVVssIEQKTEGAEKKQQ
P63104	S58	Sugiyama	YWHAZ	NEERNLLsVAyKNVVGARRssWRVVssIEQKTEGAEKKQQM
P63104	T30	Sugiyama	YWHAZ	AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63220	S65	Sugiyama	RPS21	RFNGQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF__
P63220	S68	Sugiyama	RPS21	GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____
P63261	S323	Sugiyama	ACTG1 ACTG	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261	T324	Sugiyama	ACTG1 ACTG	tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63267	S324	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267	T325	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032	S325	Sugiyama	ACTC1 ACTC	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032	T326	Sugiyama	ACTC1 ACTC	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133	S325	Sugiyama	ACTA1 ACTA	TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133	T326	Sugiyama	ACTA1 ACTA	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P78371	S470	Sugiyama	CCT2 99D8.1 CCTB	IADNAGYDSADLVAQLRAAHsEGNttAGLDMREGTIGDMAI
P83731	S38	Sugiyama	RPL24	GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P84098	S37	Sugiyama	RPL19	CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
Q00587	S350	Sugiyama	CDC42EP1 BORG5 CEP1 MSE55	HyPEMDARQERVEVLPQARAsWEsLDEEWRAPQAGsRtPVP
Q00613	S375	Sugiyama	HSF1 HSTF1	TDtEGRPPsPPPtstPEKCLsVACLDKNELSDHLDAMDSNL
Q01082	S1388	Sugiyama	SPTBN1 SPTB2	TTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSDDy
Q01105	S161	Sugiyama	SET	FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q01105	S168	Sugiyama	SET	ENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQN
Q01105	T169	Sugiyama	SET	NKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQNK
Q01581	S404	Sugiyama	HMGCS1 HMGCS	YSLKVTQDATPGSALDKITAsLCDLKSRLDSRTGVAPDVFA
Q01650	S35	Sugiyama	SLC7A5 CD98LC LAT1 MPE16	AAEEKEEAREKMLAAKsADGsAPAGEGEGVtLQRNITLLNG
Q02878	S255	Sugiyama	RPL6 TXREB1	tEKEKYEITEQRKIDQKAVDsQILPKIKAIPQLQGYLRSVF
Q04637	S1238	Sugiyama	EIF4G1 EIF4F EIF4G EIF4GI	RDAVKREAALPPVsPLKAALsEEELEKKsKAIIEEyLHLND
Q04721	S1621	Sugiyama	NOTCH2	KKQRMTRRSLPGEQEQEVAGsKVFLEIDNRQCVQDSDHCFK
Q04726	S622	Sugiyama	TLE3 KIAA1547	VWDLHNQTLVRQFQGHTDGAsCIDISHDGTKLWTGGLDNTV
Q06210	S261	Sugiyama	GFPT1 GFAT GFPT	GsQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDA
Q07021	S213	Sugiyama	C1QBP GC1QBP HABP1 SF2P32	VGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDSLDW
Q08209	S492	Sugiyama	PPP3CA CALNA CNA	EAKGLDRINERMPPRRDAMPsDANLNsINKALTSETNGTDS
Q08379	S123	Sugiyama	GOLGA2	SQNHDADNVPNLMDETKTFSsTESLRQLSQQLNGLVCESAT
Q09028	S146	Sugiyama	RBBP4 RBAP48	EVNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGE
Q09028	S147	Sugiyama	RBBP4 RBAP48	VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC
Q09666	S220	Sugiyama	AHNAK PM227	QsGKtVIRLPsGsGAAsPtGsAVDIRAGAIsAsGPELQGAG
Q12931	S361	Sugiyama	TRAP1 HSP75 HSPC5	SIFYVPDMKPSMFDVSRELGsSVALYSRKVLIQTKATDILP
Q13098	S483	Sugiyama	GPS1 COPS1 CSN1	QIHVKsPPREGsQGELtPANsQsRMstNM____________
Q13098	S485	Sugiyama	GPS1 COPS1 CSN1	HVKsPPREGsQGELtPANsQsRMstNM______________
Q13136	S338	Sugiyama	PPFIA1 LIP1	MEERITTLEKRYLAAQREATsVHDLNDKLENEIANKDSMHR
Q13136	S668	Sugiyama	PPFIA1 LIP1	EEKENTEQRAEEIESRVGsGsLDNLGRFRSMssIPPYPAss
Q13164	T553	Sugiyama	MAPK7 BMK1 ERK5 PRKM7	KRRQERERKERGAGASGGPStDPLAGLVLsDNDRsLLERWT
Q13200	S147	Sugiyama	PSMD2 TRAP2	SVLAMTMSGERECLKYRLVGsQEELASWGHEYVRHLAGEVA
Q13263	S473	Sugiyama	TRIM28 KAP1 RNF96 TIF1B	sGDDPyssAEPHVsGVKRsRsGEGEVsGLMRKVPRVsLERL
Q13263	S784	Sugiyama	TRIM28 KAP1 RNF96 TIF1B	DVGRMFKQFNKLTEDKADVQsIIGLQRFFETRMNEAFGDTK
Q13283	S362	Sugiyama	G3BP1 G3BP	LFIGNLPHEVDKSELKDFFQsyGNVVELRINsGGKLPNFGF
Q13283	S67	Sugiyama	G3BP1 G3BP	sNGKPADAVyGQKEIHRKVMsQNFtNCHTKIRHVDAHATLN
Q13347	S217	Sugiyama	EIF3I EIF3S2 TRIP1	sRDMtMFVtASKDNTAKLFDsttLEHQKTFRTERPVNSAAL
Q13470	S502	SIGNOR\|PSP	TNK1	PPARGQRRNMPLERMKGIsRsLEsVLsLGPRPtGGGssPPE
Q13765	S186	Sugiyama	NACA HSD48	sEEEEVDEtGVEVKDIELVMsQANVsRAKAVRALKNNSNDI
Q14141	T418	Sugiyama	SEPTIN6 KIAA0128 SEP2 SEPT6	QRKTAAELLQsQGsQAGGsQtLKRDKEKKNNPWLCTE____
Q14152	S492	Sugiyama	EIF3A EIF3S10 KIAA0139	VDAARHCDLQVRIDHTSRTLsFGsDLNyAtREDAPIGPHLQ
Q14192	S238	Sugiyama	FHL2 DRAL SLIM3	AKKCAGCTNPISGLGGtKyIsFEERQWHNDCFNCKKCsLsL
Q14204	S3257	Sugiyama	DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325	NDKLKKMVKDQQEAEKKKVMsQEIQEQLHKQQEVIADKQMS
Q14258	S340	Sugiyama	TRIM25 EFP RNF147 ZNF147	KPVYIPEVELNHKLIKGIHQstIDLKNELKQCIGRLQEPTP
Q14568	S164	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	VAEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGT
Q14568	S52	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14568	S53	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14677	S163	Sugiyama	CLINT1 ENTH EPN4 EPNR KIAA0171	DRLREERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSK
Q14738	S598	Sugiyama	PPP2R5D	DVyTIKALEAHKRAEEFLTAsQEAL________________
Q14789	S1568	Sugiyama	GOLGB1	RDKLITEMDRSLLENQSLSssCEsLKLALEGLTEDKEKLVK
Q14974	S531	Sugiyama	KPNB1 NTF97	LETTDRPDGHQNNLRSSAyEsLMEIVKNSAKDCYPAVQKTT
Q14980	S1181	Sugiyama	NUMA1 NMP22 NUMA	DsALEtLQGQLEEKAQELGHsQsALAsAQRELAAFRTKVQD
Q15075	S356	Sugiyama	EEA1 ZFYVE2	QATLHQKDLDCQQLQsRLsAsEtsLHRIHVELSEKGEATQK
Q15293	S80	Sugiyama	RCN1 RCN	HEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGDGFVt
Q155Q3	S592	EPSD\|PSP	DIXDC1 CCD1 KIAA1735	QVGSEYRESWPPNSKLPHsQssPTVSSTCTKVLYFTDRSLT
Q15642	S296	Sugiyama	TRIP10 CIP4 STOT STP	FARPGDVEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRS
Q15785	S8	Sugiyama	TOMM34 URCC3	_____________MAPKFPDsVEELRAAGNESFRNGQyAEA
Q15818	S91	Sugiyama	NPTX1	TILSQKETIRELTAKLGRCEsQsTLDPGAGEARAGGGRKQP
Q16204	S325	Sugiyama	CCDC6 D10S170 TST1	QRKLQREMERREALCRQLsEsEssLEMDDERYFNEMsAQGL
Q16513	S583	Sugiyama	PKN2 PRK2 PRKCL2	VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs
Q16531	T1125	Sugiyama	DDB1 XAP1	MQEVVANLQYDDGSGMKREAtADDLIKVVEELtRIH_____
Q16576	S145	Sugiyama	RBBP7 RBAP46	EVNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGE
Q16576	S146	Sugiyama	RBBP7 RBAP46	VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC
Q16658	S237	Sugiyama	FSCN1 FAN1 HSN SNL	RsGKVAFRDCEGRyLAPsGPsGtLKAGKATKVGKDELFALE
Q53EL6	S46	Sugiyama	PDCD4 H731	GDEENAGTEEIKNEINGNWIsAssINEARINAKAKRRLRKN
Q5BKZ1	Y93	Sugiyama	ZNF326 ZIRD	PYESyDsRsSLGGRDLYRsGyGFNEPEQSRFGGSYGGRFES
Q5T035	S66	Sugiyama	FAM120A2P C9orf129	LSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyERSLPI
Q5VT06	S2431	Sugiyama	CEP350 CAP350 KIAA0480 GM133	SCRDKPQPMRSSTSGATSFGsNEEISECLSEKsLSIHSNVH
Q5VT52	S1070	Sugiyama	RPRD2 KIAA0460 HSPC099	TATDQQQQEEHYRIETRVsssCLDLPDSTEEKGAPIETLGy
Q5VWQ8	S747	Sugiyama	DAB2IP AF9Q34 AIP1 KIAA1743	ssysEANEPDLQMANGGKsLsMVDLQDARTLDGEAGsPAGP
Q6FI81	S170	Sugiyama	CIAPIN1 CUA001 PRO0915	ESDNLLFVQITGKKPNFEVGsSRQLKLsITKKssPsVKPAV
Q6GYQ0	T798	Sugiyama	RALGAPA1 GARNL1 KIAA0884 TULIP1	tGNEVFGALNEEQPLPRssstsDILEPFTVERAKVNKEDMS
Q6NVY1	S381	Sugiyama	HIBCH	PADLKEVtEEDLNNHFKSLGsSDLKF_______________
Q6P1J9	S178	Sugiyama	CDC73 C1orf28 HRPT2	EGHKEGIVQTEQIRSLsEAMsVEKIAAIKAKIMAKKRSTIK
Q6P996	S722	Sugiyama	PDXDC1 KIAA0251	PGQKPFKRsLRGsDALsEtssVsHIEDLEKVERLssGPEQI
Q6PID6	S19	Sugiyama	TTC33	__MASFGWKRKIGEKVSKVTsQQFEAEAADEKDVVDNDEGN
Q6ZMR3	S161	Sugiyama	LDHAL6A LDHL2	DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q7L2H7	S367	Sugiyama	EIF3M HFLB5 PCID1 GA17 PNAS-125	WQQLyDTLNAWKQNLNKVKNsLLsLsDt_____________
Q7Z2W4	S492	Sugiyama	ZC3HAV1 ZC3HDC2 PRO1677	VQATGRIADDADPRVALVNDsLsDVtsTtssRVDDHDSEEI
Q7Z417	S671	Sugiyama	NUFIP2 KIAA1321 PIG1	DsWGsFDLRAAIVYHTKEMEsIWNLQKQDPKRIItyNEAMD
Q7Z460	S1196	Sugiyama	CLASP1 KIAA0622 MAST1	EEIYSSLRGVTEAIEKFsFRsQEDLNEPIKRDGKKECDIVs
Q7Z460	S545	Sugiyama	CLASP1 KIAA0622 MAST1	yHTLESSyQKALQSHLKNSDsIVsLPQsDRsssssQEsLNR
Q86V81	S239	Sugiyama	ALYREF ALY BEF THOC4	tRGGARGRGRGAGRNSKQQLsAEELDAQLDAyNARMDts__
Q86VQ1	S226	Sugiyama	GLCCI1	sCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQRSKQ
Q86W92	S636	Sugiyama	PPFIBP1 KIAA1230	RGGTRATAGPRLGWsRDLGQsNsDLDMPFAKWTKEQVCNWL
Q8IUD2	S824	Sugiyama	ERC1 ELKS KIAA1081 RAB6IP2	KKKsAQMLEEARRREDNLNDsSQQLQDSLRKKDDRIEELEE
Q8IZP0	S22	Sugiyama	ABI1 SSH3BP1	AELQMLLEEEIPSGKRALIEsyQNLTRVADyCENNyIQATD
Q8N806	S265	Sugiyama	UBR7 C14orf130	KDDVREVKVEQNsEPCAGsssEsDLQtVFKNESLNAESKSG
Q8TDD1	S624	Sugiyama	DDX54	FQQGQQGRQEQQEGPVGPAPsRPALQEKQPEKEEEEEAGEs
Q8WU90	S351	Sugiyama	ZC3H15 DFRP1 LEREPO4 HSPC303 HT010 MSTP012 PP730	DIDLSLYIPRDVDEtGItVAsLERFSTYTsDKDENKLsEAs
Q8WUI4	S155	ELM	HDAC7 HDAC7A	PPVPSLPSDPPEHFPLRKtVsEPNLKLRYKPKKSLERRKNP
Q8WWI1	S1421	Sugiyama	LMO7 FBX20 FBXO20 KIAA0858	yDIPKTEEAsSGFLPGDRNKsRsttELDDYSTNKNGNNKYL
Q8WWI1	S1510	Sugiyama	LMO7 FBX20 FBXO20 KIAA0858	RsAsVNKEPVSLPGIMRRGEsLDNLDsPRSNSWRQPPWLNQ
Q8WWI1	S704	Sugiyama	LMO7 FBX20 FBXO20 KIAA0858	KKRLMVERLFQKIYGENGsKsMsDVsAEDVQNLRQLRYEEM
Q8WWI1	S706	Sugiyama	LMO7 FBX20 FBXO20 KIAA0858	RLMVERLFQKIYGENGsKsMsDVsAEDVQNLRQLRYEEMQK
Q8WXH0	S2781	Sugiyama	SYNE2 KIAA1011 NUA	ILSQIRKCKVTHDGILARQQsVEsLAEEVKDKVPSLTTYEG
Q92609	S541	Sugiyama	TBC1D5 KIAA0210	EsMPVQLNKGLSSKNIsssPsVEsLPGGREFtGsPPssAtK
Q92626	S1300	Sugiyama	PXDN KIAA0230 MG50 PRG2 PXD01 VPO VPO1	NITRVQSDVFRVAEFPHGyGsCDEIPRVDLRVWQDCCEDCR
Q92973	S339	Sugiyama	TNPO1 KPNB2 MIP1 TRN	SDIDIILLKGDVEEDEtIPDsEQDIRPRFHRSRTVAQQHDE
Q92974	S711	Sugiyama	ARHGEF2 KIAA0651 LFP40	sGGNtsPGVtANGEARTFNGsIELCRADsDssQRDRNGNQL
Q93045	S80	Sugiyama	STMN2 SCG10 SCGN10	PPsPISEAPRTLAsPKKKDLsLEEIQKKLEAAEERRKsQEA
Q96A72	S108	Sugiyama	MAGOHB MAGOH2	QELEIVIGDEHISFTTSKIGsLIDVNQSKDPEGLRVFYYLV
Q96D15	S98	Sugiyama	RCN3 UNQ239/PRO272	ARLGRIVDRMDRAGDGDGWVsLAELRAWIAHTQQRHIRDsV
Q96JP5	S177	Sugiyama	ZFP91 ZNF757 FKSG11	TSVSRHRDTENTRSSRSKTGsLQLICKSEPNTDQLDYDVGE
Q96KP4	S58	Sugiyama	CNDP2 CN2 CPGL HEL-S-13 PEPA	RGEIRRMMEVAAADVKQLGGsVELVDIGKQKLPDGSEIPLP
Q96N67	S1438	Sugiyama	DOCK7 KIAA1771	LGTYTIAsPPERsPsGsAFGsQENLRWRKDMTHWRQNTEKL
Q96S59	S181	Sugiyama	RANBP9 RANBPM	QEtPLPRSWsPKDKFsYIGLsQNNLRVHYKGHGKTPKDAAS
Q96S59	S613	Sugiyama	RANBP9 RANBPM	DCDtEMEVDSsQLRRQLCGGsQAAIERMIHFGRELQAMSEQ
Q99613	S865	Sugiyama	EIF3C EIF3S8	HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF
Q99689	S58	EPSD\|PSP	FEZ1	LEDPSLSELENFSSEIISFKsMEDLVNEFDEKLNVCFRNYN
Q9BX40	S165	Sugiyama	LSM14B C20orf40 FAM61B RAP55B	GFPSIPVGKsPMVEQAVQtGsADNLNAKKLLPGKGTTGTQL
Q9BX40	T163	Sugiyama	LSM14B C20orf40 FAM61B RAP55B	GAGFPSIPVGKsPMVEQAVQtGsADNLNAKKLLPGKGTTGT
Q9C0C2	S1158	Sugiyama	TNKS1BP1 KIAA1741 TAB182	sPssKMEGGHFVPPGKttAGsVDWTDQLGLRNLEVssCVGs
Q9H0H5	S257	Sugiyama	RACGAP1 KIAA1478 MGCRACGAP	ETVPYWtRSRRKtGtLQPWNsDstLNSRQLEPRTETDsVGt
Q9H2G2	S518	Sugiyama	SLK KIAA0204 STK2	tVDLVSQEtGEKEANIQAVDsEVGLTKEDtQEKLGEDDKTQ
Q9H501	Y72	Sugiyama	ESF1 ABTAP C20orf6 HDCMC28P	AVDKRGRPISHSTTEDLKRFyDLsDsDsNLsGEDSKALSQK
Q9H7E9	T40	Sugiyama	C8orf33	PCAsRGARLPGPVsSARNPstVCLCPEQPTCSNADSRAHPL
Q9HA77	S548	Sugiyama	CARS2 OK/SW-cl.10	TLRRGLTAHGINIKDRssttstWELLDQRTKDQKSAG____
Q9HCN4	S301	Sugiyama	GPN1 MBDIN RPAP4 XAB1 HUSSY-23	ANAESQQQREQLERLRKDMGsVALDAGtAKDsLsPVLHPsD
Q9HCN8	S40	Sugiyama	SDF2L1 UNQ1941/PRO4424	ALLVPGGGAAKTGAELVTCGsVLKLLNTHHRVRLHSHDIKY
Q9HD42	S101	Sugiyama	CHMP1A CHMP1 KIAA0047 PCOLN3 PRSM1	TMKGVTKNMAQVTKALDKALsTMDLQKVSSVMDRFEQQVQN
Q9NQ39	S157	Sugiyama	RPS10P5 RPS10L	TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9NR19	S30	Sugiyama	ACSS2 ACAS2	sGsGSRGQEEAGAGGRARsWsPPPEVsRSAHVPSLQRYREL
Q9NYB9	S22	Sugiyama	ABI2 ARGBPIA	AELQMLLEEEIPGGRRALFDsytNLERVADyCENNyIQSAD
Q9NZ52	S415	Sugiyama	GGA3 KIAA0154	LCLGLADPAPNVPPKESAGNsQWHLLQREQsDLDFFSPRPG
Q9NZB2	S417	Sugiyama	FAM120A C9orf10 KIAA0183 OSSA	LSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyERssPI
Q9P0L2	S100	Sugiyama	MARK1 KIAA1477 MARK	VLTGREVAVKIIDKTQLNPTsLQKLFREVRIMKILNHPNIV
Q9P0L2	S20	Sugiyama	MARK1 KIAA1477 MARK	_MSARTPLPTVNERDTENHTsVDGytEPHIQPTKSSSRQNI
Q9P0L2	S382	Sugiyama	MARK1 KIAA1477 MARK	MATYILLGRKPPEFEGGESLssGNLCQRsRPssDLNNstLQ
Q9P0L2	S383	Sugiyama	MARK1 KIAA1477 MARK	ATYILLGRKPPEFEGGESLssGNLCQRsRPssDLNNstLQs
Q9P0L2	S393	Sugiyama	MARK1 KIAA1477 MARK	PEFEGGESLssGNLCQRsRPssDLNNstLQsPAHLKVQRSI
Q9P0L2	S399	Sugiyama	MARK1 KIAA1477 MARK	ESLssGNLCQRsRPssDLNNstLQsPAHLKVQRSISANQKQ
Q9P0L2	S403	Sugiyama	MARK1 KIAA1477 MARK	sGNLCQRsRPssDLNNstLQsPAHLKVQRSISANQKQRRFs
Q9P0L2	S423	Sugiyama	MARK1 KIAA1477 MARK	sPAHLKVQRSISANQKQRRFsDHAGPSIPPAVsYTKRPQAN
Q9P0L2	S435	Sugiyama	MARK1 KIAA1477 MARK	ANQKQRRFsDHAGPSIPPAVsYTKRPQANsVEsEQKEEWDK
Q9P0L2	S444	Sugiyama	MARK1 KIAA1477 MARK	DHAGPSIPPAVsYTKRPQANsVEsEQKEEWDKDVARKLGst
Q9P0L2	S447	Sugiyama	MARK1 KIAA1477 MARK	GPSIPPAVsYTKRPQANsVEsEQKEEWDKDVARKLGsttVG
Q9P0L2	S46	Sugiyama	MARK1 KIAA1477 MARK	EPHIQPTKSSSRQNIPRCRNsITsAtDEQPHIGNYRLQKTI
Q9P0L2	S463	Sugiyama	MARK1 KIAA1477 MARK	NsVEsEQKEEWDKDVARKLGsttVGsKsEMTAsPLVGPERK
Q9P0L2	S470	Sugiyama	MARK1 KIAA1477 MARK	KEEWDKDVARKLGsttVGsKsEMTAsPLVGPERKKsstIPS
Q9P0L2	S475	Sugiyama	MARK1 KIAA1477 MARK	KDVARKLGsttVGsKsEMTAsPLVGPERKKsstIPSNNVYS
Q9P0L2	S485	Sugiyama	MARK1 KIAA1477 MARK	tVGsKsEMTAsPLVGPERKKsstIPSNNVYSGGsMARRNtY
Q9P0L2	S486	Sugiyama	MARK1 KIAA1477 MARK	VGsKsEMTAsPLVGPERKKsstIPSNNVYSGGsMARRNtYV
Q9P0L2	S49	Sugiyama	MARK1 KIAA1477 MARK	IQPTKSSSRQNIPRCRNsITsAtDEQPHIGNYRLQKTIGKG
Q9P0L2	S498	Sugiyama	MARK1 KIAA1477 MARK	VGPERKKsstIPSNNVYSGGsMARRNtYVCERTTDRYVALQ
Q9P0L2	S588	Sugiyama	MARK1 KIAA1477 MARK	TIKDGSEAYRPGTTQRVPAAsPsAHsISTAtPDRTRFPRGS
Q9P0L2	S590	Sugiyama	MARK1 KIAA1477 MARK	KDGSEAYRPGTTQRVPAAsPsAHsISTAtPDRTRFPRGSSS
Q9P0L2	S593	Sugiyama	MARK1 KIAA1477 MARK	SEAYRPGTTQRVPAAsPsAHsISTAtPDRTRFPRGSSSRst
Q9P0L2	S624	Sugiyama	MARK1 KIAA1477 MARK	FPRGSSSRstFHGEQLRERRsVAyNGPPAsPSHETGAFAHA
Q9P0L2	S633	Sugiyama	MARK1 KIAA1477 MARK	tFHGEQLRERRsVAyNGPPAsPSHETGAFAHARRGTsTGII
Q9P0L2	S711	Sugiyama	MARK1 KIAA1477 MARK	EGKDSKPRSLRFTWSMKTTSsMDPNDMMREIRKVLDANNCD
Q9P0L2	T25	Sugiyama	MARK1 KIAA1477 MARK	TPLPTVNERDTENHTsVDGytEPHIQPTKSSSRQNIPRCRN
Q9P0L2	T464	Sugiyama	MARK1 KIAA1477 MARK	sVEsEQKEEWDKDVARKLGsttVGsKsEMTAsPLVGPERKK
Q9P0L2	T465	Sugiyama	MARK1 KIAA1477 MARK	VEsEQKEEWDKDVARKLGsttVGsKsEMTAsPLVGPERKKs
Q9P0L2	T487	Sugiyama	MARK1 KIAA1477 MARK	GsKsEMTAsPLVGPERKKsstIPSNNVYSGGsMARRNtYVC
Q9P0L2	T51	Sugiyama	MARK1 KIAA1477 MARK	PTKSSSRQNIPRCRNsITsAtDEQPHIGNYRLQKTIGKGNF
Q9P0L2	Y24	Sugiyama	MARK1 KIAA1477 MARK	RTPLPTVNERDTENHTsVDGytEPHIQPTKSSSRQNIPRCR
Q9P1Y5	S431	Sugiyama	CAMSAP3 KIAA1543	FGLDSDVDVVMGDPVLLRsVssDsLGPPRPAPARTPtQPPP
Q9P265	S203	Sugiyama	DIP2B KIAA1463	stsssASSTLSHGEVKGtsGsLADVFANtRIENFSAPPDVT
Q9P2E9	S1233	Sugiyama	RRBP1 KIAA1398	SAECQNYAKEVAGLRQLLLEsQSQLDAAKSEAQKQSDELAL
Q9UBF8	T426	Sugiyama	PI4KB PIK4CB	CENFDTTSVPARIPENRIRstRsVENLPECGItHEQRAGSF
Q9UBU9	S223	Sugiyama	NXF1 TAP	ELKPEQVEQLKLIMSKRYDGsQQALDLKGLRSDPDLVAQNI
Q9UGU0	S1187	Sugiyama	TCF20 KIAA0292 SPBP	sDGLPNKGMELKHGSQKLQEsCWDLsRQTsPAKSSGPPGMS
Q9UI15	S185	Sugiyama	TAGLN3 NP25	EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UII2	S63	Sugiyama	ATP5IF1 ATPI ATPIF1	AGGAFGKREQAEEERyFRAQsREQLAALKKHHEEEIVHHKK
Q9UIQ6	S51	Sugiyama	LNPEP OTASE	AKEPCLHPLEPDEVEyEPRGsRLLVRGLGEHEMEEDEEDyE
Q9UPQ0	S201	Sugiyama	LIMCH1 KIAA1102	DCWDsERsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVV
Q9UQ35	S1541	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	ssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDs
Q9UQ35	S1542	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDss
Q9UQ80	S383	Sugiyama	PA2G4 EBP1	sRKtQKKKKKKAsKtAENAtsGEtLEENEAGD_________
Q9Y2B0	S116	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	IDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKFA
Q9Y2B0	S178	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	NVKDKLCSKRtDLCDHALHIsHDEL________________
Q9Y2B0	S63	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	AQVDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLE
Q9Y2I7	S307	Sugiyama	PIKFYVE KIAA0981 PIP5K3	TRLVSVQEDAGKsPARNRsAsItNLsLDRsGsPMVPSYEts
Q9Y3B8	S203	Sugiyama	REXO2 SFN SMFN CGI-114	EYEFAPKKAAsHRALDDIsEsIKELQFyRNNIFKKKIDEKK
Q9Y450	S67	Sugiyama	HBS1L HBS1 KIAA1038	KPsVEPVEEyDyEDLKEssNsVsNHQLSGFDQARLYsCLDH
Q9Y450	S69	Sugiyama	HBS1L HBS1 KIAA1038	sVEPVEEyDyEDLKEssNsVsNHQLSGFDQARLYsCLDHMR
Q9Y490	S1535	Sugiyama	TLN1 KIAA1027 TLN	RTTNPTAKRQFVQSAKEVANsTANLVKTIKALDGAFTEENR
Q9Y4G6	S1537	Sugiyama	TLN2 KIAA0320	KTANPVAKRHFVQSAKEVANsTANLVKTIKALDGDFSEDNR
Q9Y6E0	S400	Sugiyama	STK24 MST3 STK3	ISPLFAELKEKsQACGGNLGsIEELRGAIYLAEEACPGISD
Q9Y6Y8	T893	Sugiyama	SEC23IP MSTP053	GFISSLKSAWQTLNEFARAHtsstQLQEELEKVANQIKEEE

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Signal Transduction	R-HSA-162582	1.035188e-09	8.985
Mitotic Prometaphase	R-HSA-68877	8.812493e-08	7.055
Cell Cycle	R-HSA-1640170	3.067338e-07	6.513
Kinesins	R-HSA-983189	3.529194e-07	6.452
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	6.591819e-07	6.181
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.708289e-06	5.767
Cell Cycle, Mitotic	R-HSA-69278	2.123595e-06	5.673
Apoptotic cleavage of cellular proteins	R-HSA-111465	3.947438e-06	5.404
M Phase	R-HSA-68886	1.074048e-05	4.969
Membrane Trafficking	R-HSA-199991	1.319507e-05	4.880
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	1.750057e-05	4.757
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	2.359805e-05	4.627
Amplification of signal from the kinetochores	R-HSA-141424	2.359805e-05	4.627
Interleukin-37 signaling	R-HSA-9008059	2.526190e-05	4.598
Mitotic Spindle Checkpoint	R-HSA-69618	4.190767e-05	4.378
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	5.124500e-05	4.290
Cell Cycle Checkpoints	R-HSA-69620	6.032450e-05	4.220
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	7.204857e-05	4.142
AURKA Activation by TPX2	R-HSA-8854518	9.567029e-05	4.019
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.006354e-04	3.997
Separation of Sister Chromatids	R-HSA-2467813	1.056177e-04	3.976
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.293143e-04	3.888
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.293143e-04	3.888
Axon guidance	R-HSA-422475	1.218563e-04	3.914
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.370959e-04	3.863
Apoptotic execution phase	R-HSA-75153	1.423692e-04	3.847
Recycling pathway of L1	R-HSA-437239	1.802094e-04	3.744
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	2.075260e-04	3.683
Mitotic Anaphase	R-HSA-68882	2.113203e-04	3.675
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	2.094527e-04	3.679
Mitotic Metaphase and Anaphase	R-HSA-2555396	2.339394e-04	3.631
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	2.306194e-04	3.637
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	2.342876e-04	3.630
Autophagy	R-HSA-9612973	2.661973e-04	3.575
Nervous system development	R-HSA-9675108	2.835106e-04	3.547
Signaling by Hippo	R-HSA-2028269	4.025612e-04	3.395
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	4.640048e-04	3.333
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	4.817030e-04	3.317
Golgi-to-ER retrograde transport	R-HSA-8856688	5.069430e-04	3.295
Aggrephagy	R-HSA-9646399	5.601845e-04	3.252
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	8.161400e-04	3.088
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	8.776462e-04	3.057
Macroautophagy	R-HSA-1632852	8.867458e-04	3.052
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	1.089385e-03	2.963
Cilium Assembly	R-HSA-5617833	1.111418e-03	2.954
NRAGE signals death through JNK	R-HSA-193648	1.149404e-03	2.940
Centrosome maturation	R-HSA-380287	1.126322e-03	2.948
Activation of AMPK downstream of NMDARs	R-HSA-9619483	1.471368e-03	2.832
Rab regulation of trafficking	R-HSA-9007101	1.532192e-03	2.815
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	1.845640e-03	2.734
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	1.845640e-03	2.734
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	1.767218e-03	2.753
MyD88-independent TLR4 cascade	R-HSA-166166	1.832789e-03	2.737
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	1.832789e-03	2.737
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	1.883011e-03	2.725
Programmed Cell Death	R-HSA-5357801	1.732913e-03	2.761
Post NMDA receptor activation events	R-HSA-438064	1.772120e-03	2.752
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	1.674283e-03	2.776
Apoptosis	R-HSA-109581	1.641886e-03	2.785
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.780196e-03	2.750
FOXO-mediated transcription of cell death genes	R-HSA-9614657	2.016687e-03	2.695
Selective autophagy	R-HSA-9663891	2.033719e-03	2.692
Signaling by NTRKs	R-HSA-166520	2.090315e-03	2.680
Death Receptor Signaling	R-HSA-73887	2.203816e-03	2.657
AKT phosphorylates targets in the cytosol	R-HSA-198323	2.385598e-03	2.622
Cytokine Signaling in Immune system	R-HSA-1280215	2.320894e-03	2.634
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	2.402751e-03	2.619
Signaling by ALK in cancer	R-HSA-9700206	2.402751e-03	2.619
Cellular response to heat stress	R-HSA-3371556	2.430140e-03	2.614
L1CAM interactions	R-HSA-373760	2.523186e-03	2.598
Mitotic G2-G2/M phases	R-HSA-453274	2.572962e-03	2.590
Impaired BRCA2 binding to PALB2	R-HSA-9709603	2.724927e-03	2.565
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	2.701462e-03	2.568
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	3.037552e-03	2.517
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	3.189006e-03	2.496
Signaling by NTRK1 (TRKA)	R-HSA-187037	3.226254e-03	2.491
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	3.391576e-03	2.470
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	3.437366e-03	2.464
Post-chaperonin tubulin folding pathway	R-HSA-389977	3.619222e-03	2.441
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	3.619222e-03	2.441
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	3.619222e-03	2.441
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	3.619222e-03	2.441
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	3.619222e-03	2.441
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	3.481654e-03	2.458
PI Metabolism	R-HSA-1483255	4.114905e-03	2.386
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	4.641302e-03	2.333
PKR-mediated signaling	R-HSA-9833482	4.757692e-03	2.323
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	4.874973e-03	2.312
Impaired BRCA2 binding to RAD51	R-HSA-9709570	5.147520e-03	2.288
Striated Muscle Contraction	R-HSA-390522	5.683873e-03	2.245
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	5.545480e-03	2.256
Signaling downstream of RAS mutants	R-HSA-9649948	5.545480e-03	2.256
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	5.545480e-03	2.256
Resolution of D-Loop Structures	R-HSA-5693537	5.683873e-03	2.245
Signaling by RAF1 mutants	R-HSA-9656223	5.339957e-03	2.272
Signaling by RAS mutants	R-HSA-6802949	5.545480e-03	2.256
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	5.430535e-03	2.265
G2/M Transition	R-HSA-69275	5.679646e-03	2.246
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	5.708624e-03	2.243
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	6.033946e-03	2.219
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	6.083534e-03	2.216
Regulation of TP53 Activity	R-HSA-5633007	6.429246e-03	2.192
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	6.096448e-03	2.215
Transport of connexons to the plasma membrane	R-HSA-190872	6.432597e-03	2.192
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	6.635025e-03	2.178
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	6.905419e-03	2.161
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	6.905419e-03	2.161
TRP channels	R-HSA-3295583	7.066702e-03	2.151
G alpha (12/13) signalling events	R-HSA-416482	7.162623e-03	2.145
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	7.495569e-03	2.125
AKT phosphorylates targets in the nucleus	R-HSA-198693	8.049352e-03	2.094
ALK mutants bind TKIs	R-HSA-9700645	8.049352e-03	2.094
NGF-stimulated transcription	R-HSA-9031628	7.682348e-03	2.115
Organelle biogenesis and maintenance	R-HSA-1852241	8.165004e-03	2.088
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	8.743733e-03	2.058
Regulation of IFNG signaling	R-HSA-877312	8.748963e-03	2.058
Signaling by Interleukins	R-HSA-449147	9.198780e-03	2.036
Signaling by TCF7L2 mutants	R-HSA-5339700	9.378029e-03	2.028
Regulation of NFE2L2 gene expression	R-HSA-9818749	9.931343e-03	2.003
PI3K/AKT Signaling in Cancer	R-HSA-2219528	9.696595e-03	2.013
ISG15 antiviral mechanism	R-HSA-1169408	9.465552e-03	2.024
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	1.000059e-02	2.000
AKT-mediated inactivation of FOXO1A	R-HSA-211163	1.119091e-02	1.951
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	1.142034e-02	1.942
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.185029e-02	1.926
PKMTs methylate histone lysines	R-HSA-3214841	1.026637e-02	1.989
mRNA Splicing - Major Pathway	R-HSA-72163	1.053609e-02	1.977
Signaling by ERBB2	R-HSA-1227986	1.020835e-02	1.991
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	1.187200e-02	1.925
MAP kinase activation	R-HSA-450294	1.167663e-02	1.933
Vesicle-mediated transport	R-HSA-5653656	1.099699e-02	1.959
Muscle contraction	R-HSA-397014	1.162441e-02	1.935
Nephrin family interactions	R-HSA-373753	1.066495e-02	1.972
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	1.187200e-02	1.925
HSF1-dependent transactivation	R-HSA-3371571	1.207318e-02	1.918
Cellular responses to stress	R-HSA-2262752	1.222334e-02	1.913
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	1.343565e-02	1.872
Platelet calcium homeostasis	R-HSA-418360	1.303948e-02	1.885
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.262656e-02	1.899
Cellular responses to stimuli	R-HSA-8953897	1.341712e-02	1.872
Heme signaling	R-HSA-9707616	1.330732e-02	1.876
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.408120e-02	1.851
Intracellular signaling by second messengers	R-HSA-9006925	1.421190e-02	1.847
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	1.461168e-02	1.835
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	1.481396e-02	1.829
DNA Double-Strand Break Repair	R-HSA-5693532	1.485342e-02	1.828
TRIF-mediated programmed cell death	R-HSA-2562578	1.500877e-02	1.824
MHC class II antigen presentation	R-HSA-2132295	1.533768e-02	1.814
Regulation of localization of FOXO transcription factors	R-HSA-9614399	1.606877e-02	1.794
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	1.606877e-02	1.794
FOXO-mediated transcription	R-HSA-9614085	1.696611e-02	1.770
Downregulation of ERBB2 signaling	R-HSA-8863795	1.570376e-02	1.804
G2/M DNA damage checkpoint	R-HSA-69473	1.582216e-02	1.801
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	2.004171e-02	1.698
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	2.004171e-02	1.698
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	2.004171e-02	1.698
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	2.004171e-02	1.698
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	2.004171e-02	1.698
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	2.004171e-02	1.698
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	2.004171e-02	1.698
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	2.004171e-02	1.698
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	2.004171e-02	1.698
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	2.004171e-02	1.698
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	2.004171e-02	1.698
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	1.857960e-02	1.731
Chaperone Mediated Autophagy	R-HSA-9613829	1.863000e-02	1.730
Netrin-1 signaling	R-HSA-373752	1.900511e-02	1.721
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	1.857960e-02	1.731
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.992435e-02	1.701
Interleukin-17 signaling	R-HSA-448424	1.851516e-02	1.732
Toll-like Receptor Cascades	R-HSA-168898	1.956069e-02	1.709
Glycolysis	R-HSA-70171	1.867898e-02	1.729
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	2.073782e-02	1.683
Cargo trafficking to the periciliary membrane	R-HSA-5620920	2.074759e-02	1.683
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	2.158111e-02	1.666
Reduction of cytosolic Ca++ levels	R-HSA-418359	2.164212e-02	1.665
PIP3 activates AKT signaling	R-HSA-1257604	2.214411e-02	1.655
FLT3 Signaling	R-HSA-9607240	2.224223e-02	1.653
mRNA Splicing	R-HSA-72172	2.238454e-02	1.650
Regulation of TP53 Degradation	R-HSA-6804757	2.238587e-02	1.650
TNF signaling	R-HSA-75893	2.350360e-02	1.629
Intrinsic Pathway for Apoptosis	R-HSA-109606	2.350360e-02	1.629
HDR through Homologous Recombination (HRR)	R-HSA-5685942	2.430587e-02	1.614
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	2.437253e-02	1.613
Nuclear Receptor transcription pathway	R-HSA-383280	2.452741e-02	1.610
Interferon Signaling	R-HSA-913531	2.455605e-02	1.610
Diseases of DNA repair	R-HSA-9675135	2.507077e-02	1.601
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	2.839184e-02	1.547
Regulation of necroptotic cell death	R-HSA-5675482	2.614879e-02	1.583
Voltage gated Potassium channels	R-HSA-1296072	2.605348e-02	1.584
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	2.839184e-02	1.547
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	2.614879e-02	1.583
Signaling by LTK	R-HSA-9842663	2.839184e-02	1.547
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	2.614879e-02	1.583
Oncogenic MAPK signaling	R-HSA-6802957	2.839870e-02	1.547
Meiosis	R-HSA-1500620	2.839870e-02	1.547
Negative regulation of MET activity	R-HSA-6807004	2.856717e-02	1.544
p75 NTR receptor-mediated signalling	R-HSA-193704	2.862138e-02	1.543
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	3.342150e-02	1.476
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	3.342150e-02	1.476
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	2.978532e-02	1.526
TRAF3-dependent IRF activation pathway	R-HSA-918233	3.247153e-02	1.488
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	3.347133e-02	1.475
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	2.997542e-02	1.523
Neurodegenerative Diseases	R-HSA-8863678	2.997542e-02	1.523
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	3.055002e-02	1.515
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	3.059337e-02	1.514
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	3.006019e-02	1.522
Interleukin-1 family signaling	R-HSA-446652	3.272455e-02	1.485
Transcriptional Regulation by TP53	R-HSA-3700989	3.207162e-02	1.494
Transcriptional Regulation by MECP2	R-HSA-8986944	3.232615e-02	1.490
Regulation of TP53 Expression and Degradation	R-HSA-6806003	3.467086e-02	1.460
Signaling by ALK	R-HSA-201556	3.467086e-02	1.460
TNFR1-induced proapoptotic signaling	R-HSA-5357786	3.469936e-02	1.460
MET activates PTPN11	R-HSA-8865999	3.532060e-02	1.452
HDMs demethylate histones	R-HSA-3214842	3.568857e-02	1.447
Interleukin-7 signaling	R-HSA-1266695	3.568857e-02	1.447
COPI-mediated anterograde transport	R-HSA-6807878	3.628109e-02	1.440
Gap junction trafficking and regulation	R-HSA-157858	3.670536e-02	1.435
Gap junction trafficking	R-HSA-190828	3.824671e-02	1.417
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	3.824671e-02	1.417
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	3.972132e-02	1.401
MET activates RAP1 and RAC1	R-HSA-8875555	3.972132e-02	1.401
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	4.166539e-02	1.380
Platelet Aggregation (Plug Formation)	R-HSA-76009	4.327430e-02	1.364
Homology Directed Repair	R-HSA-5693538	4.178220e-02	1.379
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	4.136611e-02	1.383
Diseases of programmed cell death	R-HSA-9645723	4.117116e-02	1.385
Myogenesis	R-HSA-525793	4.210668e-02	1.376
CREB phosphorylation	R-HSA-199920	4.085108e-02	1.389
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	4.210668e-02	1.376
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	4.087385e-02	1.389
MyD88 cascade initiated on plasma membrane	R-HSA-975871	4.294418e-02	1.367
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	4.294418e-02	1.367
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	4.294418e-02	1.367
Neuronal System	R-HSA-112316	4.620024e-02	1.335
Tandem pore domain potassium channels	R-HSA-1296346	3.972132e-02	1.401
Meiotic recombination	R-HSA-912446	4.634786e-02	1.334
RET signaling	R-HSA-8853659	4.685102e-02	1.329
Protein-protein interactions at synapses	R-HSA-6794362	4.792811e-02	1.319
Signaling by ERBB2 ECD mutants	R-HSA-9665348	4.856443e-02	1.314
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	4.856443e-02	1.314
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	4.856443e-02	1.314
Nuclear Envelope Breakdown	R-HSA-2980766	4.895400e-02	1.310
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	4.925880e-02	1.308
CD28 dependent PI3K/Akt signaling	R-HSA-389357	4.925880e-02	1.308
Deubiquitination	R-HSA-5688426	4.979952e-02	1.303
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	5.115416e-02	1.291
Signaling by PTK6	R-HSA-8848021	5.115416e-02	1.291
Semaphorin interactions	R-HSA-373755	5.115416e-02	1.291
ChREBP activates metabolic gene expression	R-HSA-163765	5.145035e-02	1.289
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	5.145035e-02	1.289
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	5.339684e-02	1.272
TCF dependent signaling in response to WNT	R-HSA-201681	5.340447e-02	1.272
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	5.511873e-02	1.259
GRB7 events in ERBB2 signaling	R-HSA-1306955	5.511873e-02	1.259
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	5.590510e-02	1.253
RUNX3 regulates WNT signaling	R-HSA-8951430	5.590510e-02	1.253
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	5.590510e-02	1.253
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	6.499519e-02	1.187
Mitotic Telophase/Cytokinesis	R-HSA-68884	6.499519e-02	1.187
Signaling by GSK3beta mutants	R-HSA-5339716	6.499519e-02	1.187
DCC mediated attractive signaling	R-HSA-418885	5.640287e-02	1.249
Integrin signaling	R-HSA-354192	5.546897e-02	1.256
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	5.546897e-02	1.256
RIPK1-mediated regulated necrosis	R-HSA-5213460	6.052760e-02	1.218
IGF1R signaling cascade	R-HSA-2428924	5.643747e-02	1.248
Processing of DNA double-strand break ends	R-HSA-5693607	5.582012e-02	1.253
Protein folding	R-HSA-391251	6.248003e-02	1.204
Cytochrome c-mediated apoptotic response	R-HSA-111461	6.499519e-02	1.187
Chaperonin-mediated protein folding	R-HSA-390466	6.174490e-02	1.209
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	6.208531e-02	1.207
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	5.511873e-02	1.259
Transcriptional activation of p53 responsive genes	R-HSA-69560	5.511873e-02	1.259
Activation of PUMA and translocation to mitochondria	R-HSA-139915	5.590510e-02	1.253
Sodium/Calcium exchangers	R-HSA-425561	6.499519e-02	1.187
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	6.371183e-02	1.196
MAPK family signaling cascades	R-HSA-5683057	5.855323e-02	1.232
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	5.950796e-02	1.225
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	6.499519e-02	1.187
Cell-extracellular matrix interactions	R-HSA-446353	5.640287e-02	1.249
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	5.823069e-02	1.235
Glucose metabolism	R-HSA-70326	5.965570e-02	1.224
Unfolded Protein Response (UPR)	R-HSA-381119	6.329370e-02	1.199
Regulation of PTEN gene transcription	R-HSA-8943724	6.623513e-02	1.179
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	6.837419e-02	1.165
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	6.837419e-02	1.165
MyD88 dependent cascade initiated on endosome	R-HSA-975155	6.839835e-02	1.165
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	6.846303e-02	1.165
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	6.860877e-02	1.164
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	6.860877e-02	1.164
Co-inhibition by CTLA4	R-HSA-389513	6.898235e-02	1.161
RAF activation	R-HSA-5673000	7.186167e-02	1.144
Gap junction assembly	R-HSA-190861	7.186167e-02	1.144
Regulation by c-FLIP	R-HSA-3371378	7.354120e-02	1.133
Dimerization of procaspase-8	R-HSA-69416	7.354120e-02	1.133
DNA Double Strand Break Response	R-HSA-5693606	7.450505e-02	1.128
Activation of BH3-only proteins	R-HSA-114452	7.532836e-02	1.123
Interactions of Vpr with host cellular proteins	R-HSA-176033	7.659291e-02	1.116
Cardiac conduction	R-HSA-5576891	7.708769e-02	1.113
Ion homeostasis	R-HSA-5578775	7.783305e-02	1.109
Sema4D in semaphorin signaling	R-HSA-400685	7.844635e-02	1.105
SMAC (DIABLO) binds to IAPs	R-HSA-111463	7.911134e-02	1.102
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	7.911134e-02	1.102
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	7.911134e-02	1.102
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	7.978389e-02	1.098
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	8.034191e-02	1.095
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	8.034191e-02	1.095
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	8.034191e-02	1.095
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	8.034191e-02	1.095
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	8.034191e-02	1.095
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	8.034191e-02	1.095
Repression of WNT target genes	R-HSA-4641265	8.034191e-02	1.095
Regulated Necrosis	R-HSA-5218859	8.128913e-02	1.090
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	8.190166e-02	1.087
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	8.305068e-02	1.081
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	8.305068e-02	1.081
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	1.068300e-01	0.971
TRAIL signaling	R-HSA-75158	1.068300e-01	0.971
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	1.068300e-01	0.971
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	1.068300e-01	0.971
WNT mediated activation of DVL	R-HSA-201688	9.364622e-02	1.029
CASP8 activity is inhibited	R-HSA-5218900	9.364622e-02	1.029
Signaling by EGFRvIII in Cancer	R-HSA-5637812	9.669910e-02	1.015
Constitutive Signaling by EGFRvIII	R-HSA-5637810	9.669910e-02	1.015
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	9.669910e-02	1.015
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	9.383093e-02	1.028
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	9.383093e-02	1.028
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	1.023612e-01	0.990
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	9.356337e-02	1.029
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	8.718517e-02	1.060
Negative regulation of the PI3K/AKT network	R-HSA-199418	9.872064e-02	1.006
Regulation of TNFR1 signaling	R-HSA-5357905	8.897340e-02	1.051
MAP2K and MAPK activation	R-HSA-5674135	9.511056e-02	1.022
Response of endothelial cells to shear stress	R-HSA-9860931	1.030178e-01	0.987
Interleukin-6 signaling	R-HSA-1059683	9.744281e-02	1.011
VEGFR2 mediated vascular permeability	R-HSA-5218920	8.554342e-02	1.068
MTOR signalling	R-HSA-165159	1.052933e-01	0.978
Neurexins and neuroligins	R-HSA-6794361	9.159288e-02	1.038
Signaling by WNT in cancer	R-HSA-4791275	9.665814e-02	1.015
GP1b-IX-V activation signalling	R-HSA-430116	9.364622e-02	1.029
Signaling by TGFBR3	R-HSA-9839373	8.897340e-02	1.051
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	9.383093e-02	1.028
Reproduction	R-HSA-1474165	1.045499e-01	0.981
Potassium Channels	R-HSA-1296071	9.044752e-02	1.044
Signaling by NTRK2 (TRKB)	R-HSA-9006115	1.023612e-01	0.990
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	9.364622e-02	1.029
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	1.043747e-01	0.981
Specification of primordial germ cells	R-HSA-9827857	9.669910e-02	1.015
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	9.744281e-02	1.011
Regulation of IFNA/IFNB signaling	R-HSA-912694	1.078949e-01	0.967
Co-stimulation by CD28	R-HSA-389356	1.079594e-01	0.967
Chromatin modifying enzymes	R-HSA-3247509	1.081396e-01	0.966
Activation of ATR in response to replication stress	R-HSA-176187	1.085076e-01	0.965
Transport of the SLBP independent Mature mRNA	R-HSA-159227	1.085076e-01	0.965
SARS-CoV-2-host interactions	R-HSA-9705683	1.099881e-01	0.959
DSCAM interactions	R-HSA-376172	1.114135e-01	0.953
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	1.114135e-01	0.953
TWIK related potassium channel (TREK)	R-HSA-1299503	1.114135e-01	0.953
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	1.114135e-01	0.953
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	1.114135e-01	0.953
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization	R-HSA-180897	1.114135e-01	0.953
Ephrin signaling	R-HSA-3928664	1.128173e-01	0.948
Apoptotic factor-mediated response	R-HSA-111471	1.128173e-01	0.948
Regulation of the apoptosome activity	R-HSA-9627069	1.160505e-01	0.935
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	1.160505e-01	0.935
Folding of actin by CCT/TriC	R-HSA-390450	1.160505e-01	0.935
Formation of apoptosome	R-HSA-111458	1.160505e-01	0.935
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	1.160505e-01	0.935
Signaling by Leptin	R-HSA-2586552	1.160505e-01	0.935
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	1.162202e-01	0.935
Ub-specific processing proteases	R-HSA-5689880	1.166495e-01	0.933
Clathrin-mediated endocytosis	R-HSA-8856828	1.198411e-01	0.921
Cellular Senescence	R-HSA-2559583	1.203050e-01	0.920
DNA Repair	R-HSA-73894	1.206892e-01	0.918
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.210763e-01	0.917
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	1.211324e-01	0.917
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	1.211324e-01	0.917
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	1.230167e-01	0.910
Growth hormone receptor signaling	R-HSA-982772	1.230167e-01	0.910
Transcriptional Regulation by E2F6	R-HSA-8953750	1.249167e-01	0.903
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.323488e-01	0.878
MET interacts with TNS proteins	R-HSA-8875513	1.592048e-01	0.798
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	1.592048e-01	0.798
PTK6 promotes HIF1A stabilization	R-HSA-8857538	1.377260e-01	0.861
RHOBTB3 ATPase cycle	R-HSA-9706019	1.405411e-01	0.852
Signaling by APC mutants	R-HSA-4839744	1.405411e-01	0.852
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.405411e-01	0.852
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.405411e-01	0.852
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.405411e-01	0.852
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	1.668743e-01	0.778
Activation of RAC1	R-HSA-428540	1.668743e-01	0.778
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	1.365705e-01	0.865
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	1.365705e-01	0.865
Beta-catenin phosphorylation cascade	R-HSA-196299	1.365705e-01	0.865
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	1.583690e-01	0.800
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	1.583690e-01	0.800
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.487818e-01	0.827
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.684757e-01	0.773
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.684757e-01	0.773
Signaling by ERBB2 KD Mutants	R-HSA-9664565	1.298888e-01	0.886
Late endosomal microautophagy	R-HSA-9615710	1.298888e-01	0.886
Signaling by ERBB2 in Cancer	R-HSA-1227990	1.449454e-01	0.839
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	1.449454e-01	0.839
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.449454e-01	0.839
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.608161e-01	0.794
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.608161e-01	0.794
PERK regulates gene expression	R-HSA-381042	1.486297e-01	0.828
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.486297e-01	0.828
HSF1 activation	R-HSA-3371511	1.634495e-01	0.787
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	1.396826e-01	0.855
Signaling by EGFR	R-HSA-177929	1.301028e-01	0.886
Signaling by MET	R-HSA-6806834	1.296158e-01	0.887
EPH-Ephrin signaling	R-HSA-2682334	1.450764e-01	0.838
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	1.486297e-01	0.828
PI3K Cascade	R-HSA-109704	1.291403e-01	0.889
G2/M Checkpoints	R-HSA-69481	1.647655e-01	0.783
Mitotic Prophase	R-HSA-68875	1.513254e-01	0.820
Interleukin-2 family signaling	R-HSA-451927	1.375632e-01	0.861
Interleukin-6 family signaling	R-HSA-6783589	1.391558e-01	0.856
Evasion by RSV of host interferon responses	R-HSA-9833109	1.608161e-01	0.794
Trafficking of AMPA receptors	R-HSA-399719	1.608161e-01	0.794
ERK/MAPK targets	R-HSA-198753	1.684757e-01	0.773
Long-term potentiation	R-HSA-9620244	1.562624e-01	0.806
Signaling by FGFR1 in disease	R-HSA-5655302	1.647679e-01	0.783
Signaling by WNT	R-HSA-195721	1.352864e-01	0.869
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	1.449454e-01	0.839
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	1.637563e-01	0.786
FasL/ CD95L signaling	R-HSA-75157	1.592048e-01	0.798
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.487818e-01	0.827
RAF/MAP kinase cascade	R-HSA-5673001	1.558294e-01	0.807
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	1.583690e-01	0.800
MAPK1/MAPK3 signaling	R-HSA-5684996	1.581499e-01	0.801
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	1.592048e-01	0.798
Activation of BIM and translocation to mitochondria	R-HSA-111446	1.592048e-01	0.798
Signaling by AXIN mutants	R-HSA-4839735	1.668743e-01	0.778
Signaling by AMER1 mutants	R-HSA-4839748	1.668743e-01	0.778
Phase 4 - resting membrane potential	R-HSA-5576886	1.583690e-01	0.800
TGFBR3 expression	R-HSA-9839394	1.562624e-01	0.806
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.507896e-01	0.822
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	1.538002e-01	0.813
IRE1alpha activates chaperones	R-HSA-381070	1.363007e-01	0.866
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	1.629454e-01	0.788
XBP1(S) activates chaperone genes	R-HSA-381038	1.375994e-01	0.861
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.471881e-01	0.607
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.471881e-01	0.607
Diseases of Telomere Maintenance	R-HSA-9673013	2.471881e-01	0.607
Drug-mediated inhibition of MET activation	R-HSA-9734091	2.471881e-01	0.607
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.471881e-01	0.607
TGFBR2 MSI Frameshift Mutants in Cancer	R-HSA-3642279	2.471881e-01	0.607
Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ)	R-HSA-5619088	2.471881e-01	0.607
TWIK-related spinal cord K+ channel (TRESK)	R-HSA-1299344	2.471881e-01	0.607
Impaired BRCA2 translocation to the nucleus	R-HSA-9709275	2.471881e-01	0.607
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.471881e-01	0.607
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	2.471881e-01	0.607
TICAM1 deficiency - HSE	R-HSA-5602566	2.471881e-01	0.607
Impaired BRCA2 binding to SEM1 (DSS1)	R-HSA-9763198	2.471881e-01	0.607
PLCG1 events in ERBB2 signaling	R-HSA-1251932	2.099143e-01	0.678
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	2.099143e-01	0.678
Inhibition of TSC complex formation by PKB	R-HSA-165181	2.099143e-01	0.678
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	2.099143e-01	0.678
ARL13B-mediated ciliary trafficking of INPP5E	R-HSA-5624958	3.468334e-01	0.460
NFG and proNGF binds to p75NTR	R-HSA-205017	3.468334e-01	0.460
Interactions of Tat with host cellular proteins	R-HSA-176034	3.468334e-01	0.460
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome	R-HSA-5678420	3.468334e-01	0.460
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	3.468334e-01	0.460
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	R-HSA-5083628	3.468334e-01	0.460
XAV939 stabilizes AXIN	R-HSA-5545619	3.468334e-01	0.460
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	3.468334e-01	0.460
PTEN Loss of Function in Cancer	R-HSA-5674404	3.468334e-01	0.460
Defective GFPT1 causes CMSTA1	R-HSA-4085023	3.468334e-01	0.460
IKBKB deficiency causes SCID	R-HSA-5602636	3.468334e-01	0.460
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	3.468334e-01	0.460
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	3.468334e-01	0.460
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	3.468334e-01	0.460
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	3.468334e-01	0.460
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	R-HSA-5603027	3.468334e-01	0.460
TRAF3 deficiency - HSE	R-HSA-5602571	3.468334e-01	0.460
Intestinal infectious diseases	R-HSA-8942233	3.468334e-01	0.460
MET activates PI3K/AKT signaling	R-HSA-8851907	1.712173e-01	0.766
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	1.712173e-01	0.766
Regulation of PTEN localization	R-HSA-8948747	1.712173e-01	0.766
PTK6 Expression	R-HSA-8849473	1.712173e-01	0.766
Cohesin Loading onto Chromatin	R-HSA-2470946	1.712173e-01	0.766
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	2.619332e-01	0.582
IRS activation	R-HSA-74713	2.619332e-01	0.582
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	2.619332e-01	0.582
NOSIP mediated eNOS trafficking	R-HSA-203754	2.619332e-01	0.582
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.619332e-01	0.582
G2 Phase	R-HSA-68911	2.619332e-01	0.582
Defective F9 activation	R-HSA-9673221	2.619332e-01	0.582
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	2.619332e-01	0.582
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	2.619332e-01	0.582
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	2.619332e-01	0.582
Type I hemidesmosome assembly	R-HSA-446107	2.067219e-01	0.685
RSK activation	R-HSA-444257	2.067219e-01	0.685
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	2.067219e-01	0.685
p75NTR recruits signalling complexes	R-HSA-209543	1.947866e-01	0.710
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.947866e-01	0.710
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	2.436806e-01	0.613
ARMS-mediated activation	R-HSA-170984	2.436806e-01	0.613
Lipophagy	R-HSA-9613354	2.436806e-01	0.613
Interleukin-21 signaling	R-HSA-9020958	2.436806e-01	0.613
Gap junction degradation	R-HSA-190873	2.436806e-01	0.613
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	3.140274e-01	0.503
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	3.140274e-01	0.503
PDE3B signalling	R-HSA-165160	3.140274e-01	0.503
PKB-mediated events	R-HSA-109703	3.140274e-01	0.503
IkBA variant leads to EDA-ID	R-HSA-5603029	3.140274e-01	0.503
Phase 1 - inactivation of fast Na+ channels	R-HSA-5576894	3.140274e-01	0.503
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	4.332942e-01	0.363
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	4.332942e-01	0.363
Essential pentosuria	R-HSA-5662853	4.332942e-01	0.363
Potassium transport channels	R-HSA-1296067	4.332942e-01	0.363
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	4.332942e-01	0.363
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	4.332942e-01	0.363
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	R-HSA-5083633	4.332942e-01	0.363
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	R-HSA-5083629	4.332942e-01	0.363
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	1.814739e-01	0.741
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	2.240048e-01	0.650
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	2.240048e-01	0.650
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	2.240048e-01	0.650
2-LTR circle formation	R-HSA-164843	2.815731e-01	0.550
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	2.057314e-01	0.687
PI3K events in ERBB2 signaling	R-HSA-1963642	2.057314e-01	0.687
Elevation of cytosolic Ca2+ levels	R-HSA-139853	2.057314e-01	0.687
Listeria monocytogenes entry into host cells	R-HSA-8876384	1.891898e-01	0.723
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	2.542540e-01	0.595
Signaling by LTK in cancer	R-HSA-9842640	3.652661e-01	0.437
STAT5 Activation	R-HSA-9645135	3.652661e-01	0.437
FGFR2 alternative splicing	R-HSA-6803529	2.108222e-01	0.676
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	2.108222e-01	0.676
Interaction between L1 and Ankyrins	R-HSA-445095	1.931353e-01	0.714
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	2.852647e-01	0.545
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	2.852647e-01	0.545
IRF3-mediated induction of type I IFN	R-HSA-3270619	2.852647e-01	0.545
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	2.852647e-01	0.545
PI-3K cascade:FGFR3	R-HSA-5654710	2.570501e-01	0.590
IKK complex recruitment mediated by RIP1	R-HSA-937041	2.570501e-01	0.590
Interleukin receptor SHC signaling	R-HSA-912526	2.332645e-01	0.632
IPs transport between nucleus and cytosol	R-HSA-1855170	1.948195e-01	0.710
Vpr-mediated nuclear import of PICs	R-HSA-180910	1.789401e-01	0.747
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	2.128485e-01	0.672
Signaling by Erythropoietin	R-HSA-9006335	2.330823e-01	0.632
Downstream signaling of activated FGFR3	R-HSA-5654708	2.330823e-01	0.632
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	2.564039e-01	0.591
PI-3K cascade:FGFR4	R-HSA-5654720	2.837768e-01	0.547
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	2.837768e-01	0.547
Phosphorylation of the APC/C	R-HSA-176412	3.167780e-01	0.499
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	3.583219e-01	0.446
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	3.583219e-01	0.446
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	3.583219e-01	0.446
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	3.583219e-01	0.446
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	4.149634e-01	0.382
Activated NTRK2 signals through CDK5	R-HSA-9032845	4.149634e-01	0.382
CHL1 interactions	R-HSA-447041	4.149634e-01	0.382
Netrin mediated repulsion signals	R-HSA-418886	4.149634e-01	0.382
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	4.149634e-01	0.382
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	4.149634e-01	0.382
SOS-mediated signalling	R-HSA-112412	4.149634e-01	0.382
Recycling of eIF2:GDP	R-HSA-72731	4.149634e-01	0.382
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	4.149634e-01	0.382
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	2.117773e-01	0.674
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	2.314859e-01	0.635
Downstream signaling of activated FGFR4	R-HSA-5654716	2.540124e-01	0.595
SHC1 events in ERBB2 signaling	R-HSA-1250196	2.540124e-01	0.595
SWI/SNF chromatin remodelers	R-HSA-9932451	2.801251e-01	0.553
ATP-dependent chromatin remodelers	R-HSA-9932444	2.801251e-01	0.553
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	2.290366e-01	0.640
Attenuation phase	R-HSA-3371568	2.290366e-01	0.640
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	3.485498e-01	0.458
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	3.485498e-01	0.458
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	3.485498e-01	0.458
EGFR downregulation	R-HSA-182971	2.754688e-01	0.560
Ribosomal scanning and start codon recognition	R-HSA-72702	2.049888e-01	0.688
Signaling by EGFR in Cancer	R-HSA-1643713	3.043121e-01	0.517
MET activates RAS signaling	R-HSA-8851805	3.963932e-01	0.402
SHC-related events triggered by IGF1R	R-HSA-2428933	3.963932e-01	0.402
IRAK1 recruits IKK complex	R-HSA-937039	3.963932e-01	0.402
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	3.963932e-01	0.402
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	3.963932e-01	0.402
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	3.803537e-01	0.420
ROBO receptors bind AKAP5	R-HSA-9010642	4.626298e-01	0.335
MET receptor recycling	R-HSA-8875656	4.626298e-01	0.335
Formation of annular gap junctions	R-HSA-196025	4.626298e-01	0.335
FGFR1b ligand binding and activation	R-HSA-190370	4.626298e-01	0.335
Activated NTRK2 signals through PI3K	R-HSA-9028335	4.626298e-01	0.335
Regulation of PTEN stability and activity	R-HSA-8948751	2.542105e-01	0.595
PI-3K cascade:FGFR1	R-HSA-5654689	3.662574e-01	0.436
Notch-HLH transcription pathway	R-HSA-350054	3.662574e-01	0.436
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	2.164372e-01	0.665
Translation initiation complex formation	R-HSA-72649	2.704927e-01	0.568
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	1.899363e-01	0.721
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	4.338293e-01	0.363
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	1.961980e-01	0.707
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	2.104732e-01	0.677
GAB1 signalosome	R-HSA-180292	4.119834e-01	0.385
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	2.601560e-01	0.585
Signaling by CSF3 (G-CSF)	R-HSA-9674555	3.785307e-01	0.422
Nonsense-Mediated Decay (NMD)	R-HSA-927802	2.376447e-01	0.624
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	2.376447e-01	0.624
mRNA 3'-end processing	R-HSA-72187	3.492047e-01	0.457
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	3.608495e-01	0.443
Downstream signaling of activated FGFR1	R-HSA-5654687	3.876448e-01	0.412
Downstream signaling of activated FGFR2	R-HSA-5654696	3.876448e-01	0.412
Activation of the pre-replicative complex	R-HSA-68962	4.034599e-01	0.394
TRAF6 mediated NF-kB activation	R-HSA-933542	4.216409e-01	0.375
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	4.703706e-01	0.328
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	4.703706e-01	0.328
Regulated proteolysis of p75NTR	R-HSA-193692	5.079324e-01	0.294
Inactivation of CDC42 and RAC1	R-HSA-428543	5.079324e-01	0.294
Metabolism of non-coding RNA	R-HSA-194441	3.559532e-01	0.449
snRNP Assembly	R-HSA-191859	3.559532e-01	0.449
Meiotic synapsis	R-HSA-1221632	3.677590e-01	0.434
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	3.806077e-01	0.420
G1/S-Specific Transcription	R-HSA-69205	4.104721e-01	0.387
PI-3K cascade:FGFR2	R-HSA-5654695	4.490426e-01	0.348
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	5.058053e-01	0.296
ERBB2 Regulates Cell Motility	R-HSA-6785631	5.058053e-01	0.296
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	4.760941e-01	0.322
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	5.040812e-01	0.297
Cellular response to starvation	R-HSA-9711097	3.690516e-01	0.433
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	4.783477e-01	0.320
Dual incision in TC-NER	R-HSA-6782135	4.612457e-01	0.336
Processive synthesis on the C-strand of the telomere	R-HSA-174414	5.026920e-01	0.299
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	5.026920e-01	0.299
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	5.026920e-01	0.299
Cristae formation	R-HSA-8949613	5.026920e-01	0.299
Formation of a pool of free 40S subunits	R-HSA-72689	4.368307e-01	0.360
Neutrophil degranulation	R-HSA-6798695	3.212274e-01	0.493
HIV Transcription Elongation	R-HSA-167169	5.005457e-01	0.301
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	5.005457e-01	0.301
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	5.005457e-01	0.301
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	4.654594e-01	0.332
Condensation of Prophase Chromosomes	R-HSA-2299718	4.996775e-01	0.301
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	4.996775e-01	0.301
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	4.982009e-01	0.303
Interferon gamma signaling	R-HSA-877300	1.879094e-01	0.726
Eukaryotic Translation Initiation	R-HSA-72613	2.323762e-01	0.634
Cap-dependent Translation Initiation	R-HSA-72737	2.323762e-01	0.634
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	3.108522e-01	0.507
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	2.649964e-01	0.577
HATs acetylate histones	R-HSA-3214847	4.949367e-01	0.305
Nucleotide Excision Repair	R-HSA-5696398	4.944950e-01	0.306
IRS-related events triggered by IGF1R	R-HSA-2428928	1.890213e-01	0.723
DARPP-32 events	R-HSA-180024	3.785307e-01	0.422
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	3.479283e-01	0.459
Circadian clock	R-HSA-9909396	2.840490e-01	0.547
Germ layer formation at gastrulation	R-HSA-9754189	2.570501e-01	0.590
Chromatin organization	R-HSA-4839726	1.910536e-01	0.719
Prolonged ERK activation events	R-HSA-169893	3.167780e-01	0.499
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	4.297159e-01	0.367
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	4.297159e-01	0.367
Sensing of DNA Double Strand Breaks	R-HSA-5693548	3.583219e-01	0.446
IRS-mediated signalling	R-HSA-112399	2.192369e-01	0.659
Eukaryotic Translation Elongation	R-HSA-156842	2.865119e-01	0.543
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	3.920166e-01	0.407
G1/S Transition	R-HSA-69206	3.453096e-01	0.462
Signaling by FGFR	R-HSA-190236	4.804853e-01	0.318
Insulin receptor signalling cascade	R-HSA-74751	2.294645e-01	0.639
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	4.297159e-01	0.367
Developmental Lineages of the Mammary Gland	R-HSA-9924644	1.726345e-01	0.763
Signaling by FGFR2	R-HSA-5654738	2.738453e-01	0.562
KEAP1-NFE2L2 pathway	R-HSA-9755511	2.948007e-01	0.530
Signal attenuation	R-HSA-74749	2.815731e-01	0.550
Integration of provirus	R-HSA-162592	3.583219e-01	0.446
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	2.374583e-01	0.624
p75NTR signals via NF-kB	R-HSA-193639	2.852647e-01	0.545
EPHB-mediated forward signaling	R-HSA-3928662	2.099566e-01	0.678
Frs2-mediated activation	R-HSA-170968	4.338293e-01	0.363
TRAF6 mediated IRF7 activation	R-HSA-933541	4.332456e-01	0.363
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	3.507351e-01	0.455
Josephin domain DUBs	R-HSA-5689877	2.815731e-01	0.550
Depolymerization of the Nuclear Lamina	R-HSA-4419969	2.309790e-01	0.636
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	2.946251e-01	0.531
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	3.384477e-01	0.471
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	4.216409e-01	0.375
Signaling by FGFR4	R-HSA-5654743	3.025327e-01	0.519
NPAS4 regulates expression of target genes	R-HSA-9768919	2.314859e-01	0.635
Degradation of beta-catenin by the destruction complex	R-HSA-195253	4.294642e-01	0.367
Interleukin-15 signaling	R-HSA-8983432	1.947866e-01	0.710
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	4.159161e-01	0.381
PTEN Regulation	R-HSA-6807070	2.316078e-01	0.635
Activation of the AP-1 family of transcription factors	R-HSA-450341	2.436806e-01	0.613
Aryl hydrocarbon receptor signalling	R-HSA-8937144	3.140274e-01	0.503
Regulation of CDH11 function	R-HSA-9762292	2.815731e-01	0.550
PI3K/AKT activation	R-HSA-198203	2.815731e-01	0.550
Diseases of mitotic cell cycle	R-HSA-9675126	1.774573e-01	0.751
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	4.338293e-01	0.363
DNA Damage Recognition in GG-NER	R-HSA-5696394	3.421363e-01	0.466
CRMPs in Sema3A signaling	R-HSA-399956	4.703706e-01	0.328
VxPx cargo-targeting to cilium	R-HSA-5620916	4.740003e-01	0.324
Formation of Incision Complex in GG-NER	R-HSA-5696395	5.005457e-01	0.301
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	1.999853e-01	0.699
Signaling by FGFR1	R-HSA-5654736	4.238792e-01	0.373
Signaling by FGFR3	R-HSA-5654741	3.412149e-01	0.467
Signalling to ERKs	R-HSA-187687	3.876448e-01	0.412
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	2.542540e-01	0.595
Effects of PIP2 hydrolysis	R-HSA-114508	2.128485e-01	0.672
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	2.738453e-01	0.562
Interleukin-9 signaling	R-HSA-8985947	2.067219e-01	0.685
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	2.099143e-01	0.678
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	1.712173e-01	0.766
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	2.619332e-01	0.582
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	2.067219e-01	0.685
Role of second messengers in netrin-1 signaling	R-HSA-418890	1.947866e-01	0.710
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	3.652661e-01	0.437
Intraflagellar transport	R-HSA-5620924	1.788147e-01	0.748
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	3.963932e-01	0.402
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	3.940038e-01	0.404
Cyclin E associated events during G1/S transition	R-HSA-69202	4.294642e-01	0.367
Hedgehog 'off' state	R-HSA-5610787	4.099269e-01	0.387
Nuclear RNA decay	R-HSA-9930044	1.948195e-01	0.710
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	2.104732e-01	0.677
G1/S DNA Damage Checkpoints	R-HSA-69615	4.268946e-01	0.370
Signaling by FLT3 fusion proteins	R-HSA-9703465	3.043121e-01	0.517
Cellular responses to mechanical stimuli	R-HSA-9855142	1.924054e-01	0.716
Transcriptional Regulation by NPAS4	R-HSA-9634815	3.492047e-01	0.457
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	3.652661e-01	0.437
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	3.288500e-01	0.483
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	3.662574e-01	0.436
IL-6-type cytokine receptor ligand interactions	R-HSA-6788467	4.338293e-01	0.363
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	2.595936e-01	0.586
Mitotic G1 phase and G1/S transition	R-HSA-453279	2.452965e-01	0.610
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	4.760941e-01	0.322
Oxidative Stress Induced Senescence	R-HSA-2559580	1.899363e-01	0.721
S Phase	R-HSA-69242	4.918591e-01	0.308
Cellular response to mitochondrial stress	R-HSA-9840373	2.436806e-01	0.613
Calcineurin activates NFAT	R-HSA-2025928	2.436806e-01	0.613
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	3.140274e-01	0.503
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	2.542540e-01	0.595
NOD1/2 Signaling Pathway	R-HSA-168638	2.314859e-01	0.635
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	2.540124e-01	0.595
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	3.485498e-01	0.458
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	3.803537e-01	0.420
Defects in biotin (Btn) metabolism	R-HSA-3323169	5.079324e-01	0.294
Sema3A PAK dependent Axon repulsion	R-HSA-399954	5.058053e-01	0.296
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	5.040812e-01	0.297
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	4.982009e-01	0.303
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	4.982009e-01	0.303
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	4.982009e-01	0.303
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	4.982009e-01	0.303
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	3.485498e-01	0.458
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	3.421363e-01	0.466
Signaling by NOTCH1	R-HSA-1980143	4.154047e-01	0.382
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	3.043121e-01	0.517
Signaling by FGFR in disease	R-HSA-1226099	4.969639e-01	0.304
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	4.514136e-01	0.345
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	4.703706e-01	0.328
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	5.026920e-01	0.299
ER to Golgi Anterograde Transport	R-HSA-199977	1.957112e-01	0.708
Biotin transport and metabolism	R-HSA-196780	5.058053e-01	0.296
Extra-nuclear estrogen signaling	R-HSA-9009391	4.240465e-01	0.373
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	3.955073e-01	0.403
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	2.099143e-01	0.678
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	2.542540e-01	0.595
FGFR1 mutant receptor activation	R-HSA-1839124	1.948195e-01	0.710
Activated NTRK3 signals through PI3K	R-HSA-9603381	4.149634e-01	0.382
Polo-like kinase mediated events	R-HSA-156711	4.119834e-01	0.385
Host Interactions of HIV factors	R-HSA-162909	4.044359e-01	0.393
RMTs methylate histone arginines	R-HSA-3214858	3.217578e-01	0.492
Signaling by TGF-beta Receptor Complex	R-HSA-170834	2.793518e-01	0.554
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	2.904197e-01	0.537
Regulation of TP53 Activity through Methylation	R-HSA-6804760	4.119834e-01	0.385
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	4.216409e-01	0.375
ESR-mediated signaling	R-HSA-8939211	2.466110e-01	0.608
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	2.067219e-01	0.685
Neurofascin interactions	R-HSA-447043	3.652661e-01	0.437
Ovarian tumor domain proteases	R-HSA-5689896	1.789401e-01	0.747
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	3.196168e-01	0.495
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	3.735733e-01	0.428
Rap1 signalling	R-HSA-392517	4.432536e-01	0.353
VEGFA-VEGFR2 Pathway	R-HSA-4420097	2.220528e-01	0.654
mRNA Editing	R-HSA-75072	5.079324e-01	0.294
Estrogen-dependent gene expression	R-HSA-9018519	2.039699e-01	0.690
Spry regulation of FGF signaling	R-HSA-1295596	5.058053e-01	0.296
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	3.190657e-01	0.496
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	2.801251e-01	0.553
G-protein beta:gamma signalling	R-HSA-397795	3.196168e-01	0.495
Signaling by TGFB family members	R-HSA-9006936	3.909748e-01	0.408
Signaling by ROBO receptors	R-HSA-376176	2.329458e-01	0.633
Signaling by VEGF	R-HSA-194138	3.453096e-01	0.462
Formation of editosomes by ADAR proteins	R-HSA-77042	2.471881e-01	0.607
Manipulation of host energy metabolism	R-HSA-9636667	3.468334e-01	0.460
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	3.468334e-01	0.460
Co-stimulation by ICOS	R-HSA-9927354	2.067219e-01	0.685
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	3.140274e-01	0.503
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	3.140274e-01	0.503
mRNA Editing: A to I Conversion	R-HSA-75064	4.332942e-01	0.363
Influenza Virus Induced Apoptosis	R-HSA-168277	4.332942e-01	0.363
C6 deamination of adenosine	R-HSA-75102	4.332942e-01	0.363
Defective ABCC8 can cause hypo- and hyper-glycemias	R-HSA-5683177	4.332942e-01	0.363
Regulation of cortical dendrite branching	R-HSA-8985801	4.332942e-01	0.363
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	4.332942e-01	0.363
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	2.240048e-01	0.650
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	1.950633e-01	0.710
Negative regulation of FLT3	R-HSA-9706369	3.167780e-01	0.499
Cation-coupled Chloride cotransporters	R-HSA-426117	4.149634e-01	0.382
Phase 3 - rapid repolarisation	R-HSA-5576890	4.149634e-01	0.382
FLT3 signaling in disease	R-HSA-9682385	2.703366e-01	0.568
Mitochondrial calcium ion transport	R-HSA-8949215	3.385385e-01	0.470
Adrenoceptors	R-HSA-390696	4.626298e-01	0.335
Phase 0 - rapid depolarisation	R-HSA-5576892	3.536259e-01	0.451
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	3.648397e-01	0.438
Prolactin receptor signaling	R-HSA-1170546	4.703706e-01	0.328
Physiological factors	R-HSA-5578768	4.703706e-01	0.328
Unwinding of DNA	R-HSA-176974	5.079324e-01	0.294
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	5.079324e-01	0.294
Metalloprotease DUBs	R-HSA-5689901	4.760941e-01	0.322
rRNA modification in the nucleus and cytosol	R-HSA-6790901	4.268946e-01	0.370
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	4.789917e-01	0.320
Regulation of T cell activation by CD28 family	R-HSA-388841	3.461013e-01	0.461
Regulation of PD-L1(CD274) expression	R-HSA-9909648	4.578775e-01	0.339
Signaling by Nuclear Receptors	R-HSA-9006931	2.372790e-01	0.625
Signaling by FGFR4 in disease	R-HSA-5655291	4.703706e-01	0.328
Inositol phosphate metabolism	R-HSA-1483249	2.376447e-01	0.624
Platelet activation, signaling and aggregation	R-HSA-76002	3.256230e-01	0.487
Early Phase of HIV Life Cycle	R-HSA-162594	5.040812e-01	0.297
Signaling by NOTCH1 in Cancer	R-HSA-2644603	4.982009e-01	0.303
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.763414e-01	0.754
Platelet homeostasis	R-HSA-418346	4.119681e-01	0.385
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	2.049888e-01	0.688
Regulation of NPAS4 gene transcription	R-HSA-9768777	5.079324e-01	0.294
Interactions of Rev with host cellular proteins	R-HSA-177243	2.290366e-01	0.640
Downstream signal transduction	R-HSA-186763	2.754688e-01	0.560
Signaling by SCF-KIT	R-HSA-1433557	1.943507e-01	0.711
PECAM1 interactions	R-HSA-210990	3.199268e-01	0.495
TBC/RABGAPs	R-HSA-8854214	1.943507e-01	0.711
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	2.192369e-01	0.659
Adaptive Immune System	R-HSA-1280218	4.942246e-01	0.306
STING mediated induction of host immune responses	R-HSA-1834941	4.432536e-01	0.353
Signaling by PDGFR in disease	R-HSA-9671555	3.385385e-01	0.470
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	3.196168e-01	0.495
Gluconeogenesis	R-HSA-70263	4.004366e-01	0.397
Transcriptional regulation by RUNX1	R-HSA-8878171	3.841917e-01	0.415
Transcriptional regulation of granulopoiesis	R-HSA-9616222	2.958510e-01	0.529
Muscarinic acetylcholine receptors	R-HSA-390648	2.619332e-01	0.582
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	2.436806e-01	0.613
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	3.140274e-01	0.503
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	2.128485e-01	0.672
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	2.837768e-01	0.547
Transcriptional regulation by small RNAs	R-HSA-5578749	4.633627e-01	0.334
RAB geranylgeranylation	R-HSA-8873719	4.982009e-01	0.303
DAG and IP3 signaling	R-HSA-1489509	3.412149e-01	0.467
Regulation of KIT signaling	R-HSA-1433559	4.703706e-01	0.328
Smooth Muscle Contraction	R-HSA-445355	4.989026e-01	0.302
Interleukin-12 family signaling	R-HSA-447115	2.940216e-01	0.532
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	2.260585e-01	0.646
Calmodulin induced events	R-HSA-111933	4.104721e-01	0.387
Breakdown of the nuclear lamina	R-HSA-352238	3.468334e-01	0.460
Inhibition of membrane repair	R-HSA-9635644	3.468334e-01	0.460
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	3.140274e-01	0.503
Platelet sensitization by LDL	R-HSA-432142	2.309790e-01	0.636
Synthesis of PI	R-HSA-1483226	3.199268e-01	0.495
Syndecan interactions	R-HSA-3000170	2.332645e-01	0.632
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	1.948195e-01	0.710
OAS antiviral response	R-HSA-8983711	3.963932e-01	0.402
Maturation of nucleoprotein	R-HSA-9683610	4.338293e-01	0.363
MAPK1 (ERK2) activation	R-HSA-112411	5.079324e-01	0.294
CaM pathway	R-HSA-111997	4.104721e-01	0.387
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	4.530017e-01	0.344
G0 and Early G1	R-HSA-1538133	4.530017e-01	0.344
GPVI-mediated activation cascade	R-HSA-114604	4.104721e-01	0.387
Formation of definitive endoderm	R-HSA-9823730	4.740003e-01	0.324
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	3.652661e-01	0.437
Nuclear import of Rev protein	R-HSA-180746	2.314859e-01	0.635
Regulation of MECP2 expression and activity	R-HSA-9022692	3.196168e-01	0.495
Tie2 Signaling	R-HSA-210993	4.119834e-01	0.385
Malate-aspartate shuttle	R-HSA-9856872	4.703706e-01	0.328
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	5.026920e-01	0.299
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	1.814739e-01	0.741
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	5.058053e-01	0.296
Formation of the anterior neural plate	R-HSA-9823739	5.058053e-01	0.296
Co-inhibition by BTLA	R-HSA-9927353	2.619332e-01	0.582
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	4.332942e-01	0.363
Displacement of DNA glycosylase by APEX1	R-HSA-110357	4.149634e-01	0.382
MECP2 regulates transcription factors	R-HSA-9022707	4.149634e-01	0.382
Sodium/Proton exchangers	R-HSA-425986	4.626298e-01	0.335
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	3.735733e-01	0.428
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	5.079324e-01	0.294
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	3.043121e-01	0.517
P2Y receptors	R-HSA-417957	4.703706e-01	0.328
MITF-M-dependent gene expression	R-HSA-9856651	4.337199e-01	0.363
Metal ion SLC transporters	R-HSA-425410	2.769440e-01	0.558
Regulation of CDH11 gene transcription	R-HSA-9762293	5.079324e-01	0.294
Regulation of CDH19 Expression and Function	R-HSA-9764302	3.140274e-01	0.503
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	1.891898e-01	0.723
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	3.199268e-01	0.495
Uptake and function of diphtheria toxin	R-HSA-5336415	4.149634e-01	0.382
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	4.626298e-01	0.335
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	4.626298e-01	0.335
Respiratory syncytial virus genome replication	R-HSA-9834752	5.079324e-01	0.294
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	5.058053e-01	0.296
Activation of BAD and translocation to mitochondria	R-HSA-111447	5.058053e-01	0.296
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	4.996775e-01	0.301
Interleukin-12 signaling	R-HSA-9020591	2.207224e-01	0.656
SARS-CoV-2 Infection	R-HSA-9694516	4.846336e-01	0.315
NS1 Mediated Effects on Host Pathways	R-HSA-168276	3.315666e-01	0.479
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	5.079324e-01	0.294
Zinc transporters	R-HSA-435354	4.703706e-01	0.328
Butyrophilin (BTN) family interactions	R-HSA-8851680	5.079324e-01	0.294
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	3.662574e-01	0.436
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	4.119834e-01	0.385
Axonal growth stimulation	R-HSA-209563	5.083144e-01	0.294
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	5.083144e-01	0.294
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	5.083144e-01	0.294
Defective CYP7B1 causes SPG5A and CBAS3	R-HSA-5579013	5.083144e-01	0.294
Invadopodia formation	R-HSA-8941237	5.083144e-01	0.294
Defective GCLC causes HAGGSD	R-HSA-5578999	5.083144e-01	0.294
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	5.083144e-01	0.294
STAT6-mediated induction of chemokines	R-HSA-3249367	5.083144e-01	0.294
MET activates STAT3	R-HSA-8875791	5.083144e-01	0.294
Activation of BMF and translocation to mitochondria	R-HSA-139910	5.083144e-01	0.294
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	5.083144e-01	0.294
Histamine receptors	R-HSA-390650	5.083144e-01	0.294
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	5.102472e-01	0.292
Peptide chain elongation	R-HSA-156902	5.112631e-01	0.291
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	5.123692e-01	0.290
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	5.129743e-01	0.290
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	5.135831e-01	0.289
HIV Life Cycle	R-HSA-162587	5.144636e-01	0.289
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	5.149275e-01	0.288
RNA Polymerase II Transcription Termination	R-HSA-73856	5.164328e-01	0.287
Transcriptional regulation by RUNX2	R-HSA-8878166	5.199587e-01	0.284
Interleukin-1 signaling	R-HSA-9020702	5.235814e-01	0.281
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	5.249850e-01	0.280
Dual Incision in GG-NER	R-HSA-5696400	5.252324e-01	0.280
HIV Infection	R-HSA-162906	5.273625e-01	0.278
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	5.287449e-01	0.277
HIV elongation arrest and recovery	R-HSA-167287	5.287449e-01	0.277
Pausing and recovery of HIV elongation	R-HSA-167290	5.287449e-01	0.277
Telomere Extension By Telomerase	R-HSA-171319	5.287449e-01	0.277
Negative regulation of FGFR3 signaling	R-HSA-5654732	5.287449e-01	0.277
Pyroptosis	R-HSA-5620971	5.287449e-01	0.277
MITF-M-regulated melanocyte development	R-HSA-9730414	5.290192e-01	0.277
Signaling by NTRK3 (TRKC)	R-HSA-9034015	5.333748e-01	0.273
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	5.333748e-01	0.273
Mitochondrial protein import	R-HSA-1268020	5.344561e-01	0.272
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	5.344561e-01	0.272
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	5.399661e-01	0.268
Regulation of NF-kappa B signaling	R-HSA-9758274	5.399661e-01	0.268
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	5.399661e-01	0.268
Negative regulation of MAPK pathway	R-HSA-5675221	5.439452e-01	0.264
Platelet degranulation	R-HSA-114608	5.442152e-01	0.264
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	5.506617e-01	0.259
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	5.506617e-01	0.259
Arachidonate production from DAG	R-HSA-426048	5.506617e-01	0.259
Interleukin-27 signaling	R-HSA-9020956	5.506617e-01	0.259
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	5.506617e-01	0.259
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	5.506617e-01	0.259
Receptor Mediated Mitophagy	R-HSA-8934903	5.506617e-01	0.259
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	5.506617e-01	0.259
Defective factor IX causes hemophilia B	R-HSA-9668250	5.506617e-01	0.259
MAPK3 (ERK1) activation	R-HSA-110056	5.506617e-01	0.259
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	5.506617e-01	0.259
rRNA processing in the nucleus and cytosol	R-HSA-8868773	5.536492e-01	0.257
CLEC7A (Dectin-1) signaling	R-HSA-5607764	5.540640e-01	0.256
Negative regulation of FGFR4 signaling	R-HSA-5654733	5.541729e-01	0.256
Regulation of CDH11 Expression and Function	R-HSA-9759475	5.541729e-01	0.256
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	5.558415e-01	0.255
MAPK6/MAPK4 signaling	R-HSA-5687128	5.593391e-01	0.252
Transmission across Chemical Synapses	R-HSA-112315	5.596933e-01	0.252
DNA Damage Bypass	R-HSA-73893	5.600429e-01	0.252
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	5.600429e-01	0.252
p53-Dependent G1 DNA Damage Response	R-HSA-69563	5.600429e-01	0.252
Cell-Cell communication	R-HSA-1500931	5.606549e-01	0.251
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	5.617799e-01	0.250
mTORC1-mediated signalling	R-HSA-166208	5.617799e-01	0.250
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	5.650457e-01	0.248
Ca-dependent events	R-HSA-111996	5.650457e-01	0.248
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	5.658534e-01	0.247
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	5.697554e-01	0.244
RUNX2 regulates bone development	R-HSA-8941326	5.711619e-01	0.243
Influenza Viral RNA Transcription and Replication	R-HSA-168273	5.725843e-01	0.242
Processing of Intronless Pre-mRNAs	R-HSA-77595	5.727254e-01	0.242
Transcriptional regulation of testis differentiation	R-HSA-9690406	5.727254e-01	0.242
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	5.727254e-01	0.242
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	5.727254e-01	0.242
TNFR1-mediated ceramide production	R-HSA-5626978	5.734073e-01	0.242
NADE modulates death signalling	R-HSA-205025	5.734073e-01	0.242
ATP sensitive Potassium channels	R-HSA-1296025	5.734073e-01	0.242
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	5.734073e-01	0.242
FBXW7 Mutants and NOTCH1 in Cancer	R-HSA-2644605	5.734073e-01	0.242
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	R-HSA-2644607	5.734073e-01	0.242
Regulation of gap junction activity	R-HSA-191650	5.734073e-01	0.242
Transmission across Electrical Synapses	R-HSA-112307	5.734073e-01	0.242
Electric Transmission Across Gap Junctions	R-HSA-112303	5.734073e-01	0.242
Activation of NOXA and translocation to mitochondria	R-HSA-111448	5.734073e-01	0.242
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	5.734073e-01	0.242
Dopamine receptors	R-HSA-390651	5.734073e-01	0.242
Regulation of HMOX1 expression and activity	R-HSA-9707587	5.734073e-01	0.242
Interleukin-38 signaling	R-HSA-9007892	5.734073e-01	0.242
Generic Transcription Pathway	R-HSA-212436	5.747538e-01	0.241
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	5.789074e-01	0.237
Activation of HOX genes during differentiation	R-HSA-5619507	5.793804e-01	0.237
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	5.793804e-01	0.237
RSV-host interactions	R-HSA-9833110	5.793804e-01	0.237
trans-Golgi Network Vesicle Budding	R-HSA-199992	5.823494e-01	0.235
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	5.856880e-01	0.232
Defective pyroptosis	R-HSA-9710421	5.856880e-01	0.232
Signaling by Insulin receptor	R-HSA-74752	5.859229e-01	0.232
Mitochondrial biogenesis	R-HSA-1592230	5.867242e-01	0.232
Interleukin-20 family signaling	R-HSA-8854691	5.892139e-01	0.230
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	5.892139e-01	0.230
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	5.896918e-01	0.229
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	5.907051e-01	0.229
Activated NTRK3 signals through RAS	R-HSA-9034864	5.907051e-01	0.229
CD163 mediating an anti-inflammatory response	R-HSA-9662834	5.907051e-01	0.229
Formation of the posterior neural plate	R-HSA-9832991	5.907051e-01	0.229
Interleukin-2 signaling	R-HSA-9020558	5.907051e-01	0.229
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	5.907051e-01	0.229
Suppression of apoptosis	R-HSA-9635465	5.907051e-01	0.229
Ca2+ pathway	R-HSA-4086398	5.985677e-01	0.223
Co-inhibition by PD-1	R-HSA-389948	6.025035e-01	0.220
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	6.025951e-01	0.220
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	6.028909e-01	0.220
Budding and maturation of HIV virion	R-HSA-162588	6.028909e-01	0.220
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	6.039910e-01	0.219
Cyclin D associated events in G1	R-HSA-69231	6.058345e-01	0.218
G1 Phase	R-HSA-69236	6.058345e-01	0.218
Metabolism of RNA	R-HSA-8953854	6.058701e-01	0.218
Extension of Telomeres	R-HSA-180786	6.099662e-01	0.215
Deadenylation-dependent mRNA decay	R-HSA-429914	6.099662e-01	0.215
Signaling by Hedgehog	R-HSA-5358351	6.141971e-01	0.212
Signaling by ERBB4	R-HSA-1236394	6.144883e-01	0.211
MET promotes cell motility	R-HSA-8875878	6.147969e-01	0.211
SLC-mediated transport of inorganic anions	R-HSA-9958790	6.147969e-01	0.211
Deadenylation of mRNA	R-HSA-429947	6.156122e-01	0.211
Complex III assembly	R-HSA-9865881	6.156122e-01	0.211
Formation of RNA Pol II elongation complex	R-HSA-112382	6.170514e-01	0.210
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	6.194686e-01	0.208
Regulation of CDH1 Expression and Function	R-HSA-9764265	6.218385e-01	0.206
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	6.218385e-01	0.206
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	6.260762e-01	0.203
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	6.260762e-01	0.203
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	6.280249e-01	0.202
Condensation of Prometaphase Chromosomes	R-HSA-2514853	6.280249e-01	0.202
Activated NTRK2 signals through RAS	R-HSA-9026519	6.280249e-01	0.202
NF-kB is activated and signals survival	R-HSA-209560	6.280249e-01	0.202
RNA Polymerase II Transcription	R-HSA-73857	6.287701e-01	0.202
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	6.290289e-01	0.201
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	6.298859e-01	0.201
Defective CYP17A1 causes AH5	R-HSA-5579028	6.298859e-01	0.201
FLT3 signaling by CBL mutants	R-HSA-9706377	6.298859e-01	0.201
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	6.298859e-01	0.201
PTK6 Down-Regulation	R-HSA-8849472	6.298859e-01	0.201
Activation of AKT2	R-HSA-165158	6.298859e-01	0.201
Activation of C3 and C5	R-HSA-174577	6.298859e-01	0.201
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	6.298859e-01	0.201
Inositol transporters	R-HSA-429593	6.298859e-01	0.201
NrCAM interactions	R-HSA-447038	6.298859e-01	0.201
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	6.298859e-01	0.201
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	6.298859e-01	0.201
Zinc efflux and compartmentalization by the SLC30 family	R-HSA-435368	6.298859e-01	0.201
Non-integrin membrane-ECM interactions	R-HSA-3000171	6.300929e-01	0.201
Stimuli-sensing channels	R-HSA-2672351	6.324292e-01	0.199
PKA activation	R-HSA-163615	6.337017e-01	0.198
PKA activation in glucagon signalling	R-HSA-164378	6.337017e-01	0.198
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	6.337017e-01	0.198
Nucleotide-like (purinergic) receptors	R-HSA-418038	6.337017e-01	0.198
RNA Polymerase II Transcription Elongation	R-HSA-75955	6.351613e-01	0.197
Golgi Associated Vesicle Biogenesis	R-HSA-432722	6.351613e-01	0.197
Nuclear events mediated by NFE2L2	R-HSA-9759194	6.365092e-01	0.196
Hemostasis	R-HSA-109582	6.368590e-01	0.196
TP53 Regulates Metabolic Genes	R-HSA-5628897	6.406729e-01	0.193
Eukaryotic Translation Termination	R-HSA-72764	6.419879e-01	0.192
Regulation of RUNX2 expression and activity	R-HSA-8939902	6.441200e-01	0.191
Viral Messenger RNA Synthesis	R-HSA-168325	6.441200e-01	0.191
PLC beta mediated events	R-HSA-112043	6.441200e-01	0.191
mRNA Splicing - Minor Pathway	R-HSA-72165	6.445137e-01	0.191
Negative regulation of FGFR1 signaling	R-HSA-5654726	6.484259e-01	0.188
Assembly of the ORC complex at the origin of replication	R-HSA-68616	6.484259e-01	0.188
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	6.484259e-01	0.188
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	6.484259e-01	0.188
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	6.524638e-01	0.185
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	6.535321e-01	0.185
Inhibition of DNA recombination at telomere	R-HSA-9670095	6.558241e-01	0.183
Diseases of Immune System	R-HSA-5260271	6.558241e-01	0.183
Diseases associated with the TLR signaling cascade	R-HSA-5602358	6.558241e-01	0.183
Maternal to zygotic transition (MZT)	R-HSA-9816359	6.602711e-01	0.180
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	6.612217e-01	0.180
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	6.618232e-01	0.179
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	6.618232e-01	0.179
Signaling by FGFR2 IIIa TM	R-HSA-8851708	6.618232e-01	0.179
Translesion Synthesis by POLH	R-HSA-110320	6.618232e-01	0.179
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	6.618232e-01	0.179
Specification of the neural plate border	R-HSA-9834899	6.618232e-01	0.179
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	6.618232e-01	0.179
Other interleukin signaling	R-HSA-449836	6.618232e-01	0.179
Maturation of nucleoprotein	R-HSA-9694631	6.618232e-01	0.179
RUNX3 regulates p14-ARF	R-HSA-8951936	6.626403e-01	0.179
Serotonin clearance from the synaptic cleft	R-HSA-380615	6.626403e-01	0.179
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	6.626403e-01	0.179
RUNX3 regulates NOTCH signaling	R-HSA-8941856	6.626403e-01	0.179
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	6.626403e-01	0.179
Interleukin-35 Signalling	R-HSA-8984722	6.626403e-01	0.179
VLDLR internalisation and degradation	R-HSA-8866427	6.626403e-01	0.179
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	6.629955e-01	0.178
Gene expression (Transcription)	R-HSA-74160	6.695275e-01	0.174
Late Phase of HIV Life Cycle	R-HSA-162599	6.698181e-01	0.174
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	6.699120e-01	0.174
Epigenetic regulation of gene expression	R-HSA-212165	6.715223e-01	0.173
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	6.752907e-01	0.171
Potential therapeutics for SARS	R-HSA-9679191	6.763268e-01	0.170
Nef Mediated CD8 Down-regulation	R-HSA-182218	6.788899e-01	0.168
Noncanonical activation of NOTCH3	R-HSA-9017802	6.788899e-01	0.168
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	6.788899e-01	0.168
PTK6 Regulates Cell Cycle	R-HSA-8849470	6.788899e-01	0.168
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	6.788899e-01	0.168
Defective CSF2RB causes SMDP5	R-HSA-5688849	6.788899e-01	0.168
Defective CSF2RA causes SMDP4	R-HSA-5688890	6.788899e-01	0.168
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	6.788899e-01	0.168
CLEC7A/inflammasome pathway	R-HSA-5660668	6.788899e-01	0.168
Pentose phosphate pathway disease	R-HSA-6791465	6.788899e-01	0.168
CDC6 association with the ORC:origin complex	R-HSA-68689	6.788899e-01	0.168
Phosphorylation of Emi1	R-HSA-176417	6.788899e-01	0.168
Ceramide signalling	R-HSA-193681	6.788899e-01	0.168
Formation of the Editosome	R-HSA-75094	6.788899e-01	0.168
Signalling to p38 via RIT and RIN	R-HSA-187706	6.788899e-01	0.168
Negative feedback regulation of MAPK pathway	R-HSA-5674499	6.788899e-01	0.168
Sodium-coupled phosphate cotransporters	R-HSA-427652	6.788899e-01	0.168
Release of apoptotic factors from the mitochondria	R-HSA-111457	6.788899e-01	0.168
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	6.788899e-01	0.168
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	6.788899e-01	0.168
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	6.788899e-01	0.168
Release of Hh-Np from the secreting cell	R-HSA-5362798	6.788899e-01	0.168
Phospholipid metabolism	R-HSA-1483257	6.798517e-01	0.168
Influenza Infection	R-HSA-168255	6.813166e-01	0.167
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	6.864994e-01	0.163
EPHA-mediated growth cone collapse	R-HSA-3928663	6.881780e-01	0.162
Packaging Of Telomere Ends	R-HSA-171306	6.881780e-01	0.162
Signaling by FGFR3 in disease	R-HSA-5655332	6.881780e-01	0.162
RNA Polymerase I Promoter Opening	R-HSA-73728	6.881780e-01	0.162
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	6.883437e-01	0.162
Pregnenolone biosynthesis	R-HSA-196108	6.883437e-01	0.162
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	6.883437e-01	0.162
Signal transduction by L1	R-HSA-445144	6.883437e-01	0.162
Sensory processing of sound	R-HSA-9659379	6.890529e-01	0.162
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	6.905147e-01	0.161
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	6.905147e-01	0.161
Mitophagy	R-HSA-5205647	6.905147e-01	0.161
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	6.905147e-01	0.161
Negative regulation of FGFR2 signaling	R-HSA-5654727	6.905147e-01	0.161
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	6.905147e-01	0.161
Class I MHC mediated antigen processing & presentation	R-HSA-983169	6.912828e-01	0.160
Ion transport by P-type ATPases	R-HSA-936837	6.920641e-01	0.160
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	6.940347e-01	0.159
Intra-Golgi traffic	R-HSA-6811438	6.940347e-01	0.159
Formation of axial mesoderm	R-HSA-9796292	6.946132e-01	0.158
FGFR1c ligand binding and activation	R-HSA-190373	6.946132e-01	0.158
Chylomicron remodeling	R-HSA-8963901	6.946132e-01	0.158
Membrane binding and targetting of GAG proteins	R-HSA-174490	6.946132e-01	0.158
Processing of SMDT1	R-HSA-8949664	6.946132e-01	0.158
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	6.946132e-01	0.158
Platelet Adhesion to exposed collagen	R-HSA-75892	6.946132e-01	0.158
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	7.100866e-01	0.149
Formation of the Early Elongation Complex	R-HSA-113418	7.100866e-01	0.149
Oncogene Induced Senescence	R-HSA-2559585	7.102220e-01	0.149
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	7.120443e-01	0.147
SHC-mediated cascade:FGFR3	R-HSA-5654704	7.132710e-01	0.147
MyD88 deficiency (TLR2/4)	R-HSA-5602498	7.132710e-01	0.147
Signalling to RAS	R-HSA-167044	7.132710e-01	0.147
PKA-mediated phosphorylation of CREB	R-HSA-111931	7.132710e-01	0.147
Zygotic genome activation (ZGA)	R-HSA-9819196	7.132710e-01	0.147
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	7.162987e-01	0.145
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	7.180851e-01	0.144
Erythropoietin activates STAT5	R-HSA-9027283	7.214081e-01	0.142
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	7.214081e-01	0.142
Autointegration results in viral DNA circles	R-HSA-177539	7.214081e-01	0.142
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors	R-HSA-629587	7.214081e-01	0.142
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	7.214081e-01	0.142
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	7.214081e-01	0.142
Defective CYP11A1 causes AICSR	R-HSA-5579026	7.214081e-01	0.142
Hydrolysis of LPE	R-HSA-1483152	7.214081e-01	0.142
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	7.214081e-01	0.142
MET Receptor Activation	R-HSA-6806942	7.214081e-01	0.142
Integration of viral DNA into host genomic DNA	R-HSA-175567	7.214081e-01	0.142
Nef and signal transduction	R-HSA-164944	7.214081e-01	0.142
Leukotriene receptors	R-HSA-391906	7.214081e-01	0.142
HDL clearance	R-HSA-8964011	7.214081e-01	0.142
Retrograde neurotrophin signalling	R-HSA-177504	7.240363e-01	0.140
Synthesis of IPs in the nucleus	R-HSA-1855191	7.240363e-01	0.140
NRIF signals cell death from the nucleus	R-HSA-205043	7.240363e-01	0.140
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	7.240363e-01	0.140
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	7.240363e-01	0.140
Signal regulatory protein family interactions	R-HSA-391160	7.240363e-01	0.140
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	7.253228e-01	0.139
Lysosome Vesicle Biogenesis	R-HSA-432720	7.290289e-01	0.137
PRC2 methylates histones and DNA	R-HSA-212300	7.290289e-01	0.137
Regulation of endogenous retroelements	R-HSA-9842860	7.297273e-01	0.137
DNA methylation	R-HSA-5334118	7.308486e-01	0.136
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	7.308486e-01	0.136
Termination of translesion DNA synthesis	R-HSA-5656169	7.308486e-01	0.136
Regulation of gene expression in beta cells	R-HSA-210745	7.308486e-01	0.136
G-protein mediated events	R-HSA-112040	7.357691e-01	0.133
FRS-mediated FGFR3 signaling	R-HSA-5654706	7.366284e-01	0.133
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	7.366284e-01	0.133
SHC-mediated cascade:FGFR4	R-HSA-5654719	7.366284e-01	0.133
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	7.366284e-01	0.133
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	7.371633e-01	0.132
Interferon alpha/beta signaling	R-HSA-909733	7.382838e-01	0.132
TCR signaling	R-HSA-202403	7.449210e-01	0.128
Amine ligand-binding receptors	R-HSA-375280	7.458384e-01	0.127
SIRT1 negatively regulates rRNA expression	R-HSA-427359	7.469366e-01	0.127
Cleavage of the damaged purine	R-HSA-110331	7.469366e-01	0.127
DAP12 signaling	R-HSA-2424491	7.504744e-01	0.125
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	7.504744e-01	0.125
Erythropoietin activates RAS	R-HSA-9027284	7.510243e-01	0.124
SHC1 events in EGFR signaling	R-HSA-180336	7.510243e-01	0.124
Translesion synthesis by REV1	R-HSA-110312	7.510243e-01	0.124
Telomere C-strand synthesis initiation	R-HSA-174430	7.510243e-01	0.124
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	7.510243e-01	0.124
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	7.510243e-01	0.124
Protein methylation	R-HSA-8876725	7.510243e-01	0.124
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	7.510243e-01	0.124
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	7.510243e-01	0.124
Transport to the Golgi and subsequent modification	R-HSA-948021	7.521644e-01	0.124
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	7.542128e-01	0.123
NOSTRIN mediated eNOS trafficking	R-HSA-203641	7.582986e-01	0.120
IFNG signaling activates MAPKs	R-HSA-9732724	7.582986e-01	0.120
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	7.582986e-01	0.120
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	7.582986e-01	0.120
DAG1 core M1 glycosylations	R-HSA-8932506	7.582986e-01	0.120
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	7.582986e-01	0.120
mRNA Editing: C to U Conversion	R-HSA-72200	7.582986e-01	0.120
Nef Mediated CD4 Down-regulation	R-HSA-167590	7.582986e-01	0.120
Electron transport from NADPH to Ferredoxin	R-HSA-2395516	7.582986e-01	0.120
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	7.582986e-01	0.120
VLDL clearance	R-HSA-8964046	7.582986e-01	0.120
Maturation of replicase proteins	R-HSA-9694301	7.582986e-01	0.120
FRS-mediated FGFR4 signaling	R-HSA-5654712	7.584524e-01	0.120
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.584524e-01	0.120
Signaling by KIT in disease	R-HSA-9669938	7.584524e-01	0.120
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	7.584524e-01	0.120
LDL clearance	R-HSA-8964038	7.584524e-01	0.120
Telomere Maintenance	R-HSA-157579	7.598309e-01	0.119
Amino acids regulate mTORC1	R-HSA-9639288	7.609492e-01	0.119
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	7.609492e-01	0.119
Fanconi Anemia Pathway	R-HSA-6783310	7.616229e-01	0.118
Immune System	R-HSA-168256	7.627083e-01	0.118
Depurination	R-HSA-73927	7.639521e-01	0.117
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	7.640123e-01	0.117
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	7.669274e-01	0.115
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	7.689817e-01	0.114
tRNA processing in the nucleus	R-HSA-6784531	7.746634e-01	0.111
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	7.750787e-01	0.111
Class I peroxisomal membrane protein import	R-HSA-9603798	7.757061e-01	0.110
Translesion synthesis by POLI	R-HSA-5656121	7.757061e-01	0.110
Killing mechanisms	R-HSA-9664420	7.757061e-01	0.110
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	7.757061e-01	0.110
WNT5A-dependent internalization of FZD4	R-HSA-5099900	7.757061e-01	0.110
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	7.757061e-01	0.110
Differentiation of T cells	R-HSA-9945266	7.757061e-01	0.110
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	7.757061e-01	0.110
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	7.757061e-01	0.110
Serotonin and melatonin biosynthesis	R-HSA-209931	7.757061e-01	0.110
Activation of SMO	R-HSA-5635838	7.757061e-01	0.110
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	7.757061e-01	0.110
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	7.787895e-01	0.109
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	7.800869e-01	0.108
SARS-CoV-1-host interactions	R-HSA-9692914	7.832390e-01	0.106
Inwardly rectifying K+ channels	R-HSA-1296065	7.863950e-01	0.104
DNA strand elongation	R-HSA-69190	7.863950e-01	0.104
HDACs deacetylate histones	R-HSA-3214815	7.885640e-01	0.103
Signaling by NOTCH3	R-HSA-9012852	7.885640e-01	0.103
Assembly of the pre-replicative complex	R-HSA-68867	7.897656e-01	0.103
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	7.903060e-01	0.102
EGFR interacts with phospholipase C-gamma	R-HSA-212718	7.903060e-01	0.102
DAG1 core M2 glycosylations	R-HSA-8932504	7.903060e-01	0.102
Myoclonic epilepsy of Lafora	R-HSA-3785653	7.903060e-01	0.102
Signaling by MRAS-complex mutants	R-HSA-9660537	7.903060e-01	0.102
Highly calcium permeable nicotinic acetylcholine receptors	R-HSA-629597	7.903060e-01	0.102
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	7.903060e-01	0.102
Axonal growth inhibition (RHOA activation)	R-HSA-193634	7.903060e-01	0.102
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	7.903060e-01	0.102
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	7.903060e-01	0.102
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	7.903060e-01	0.102
Fructose biosynthesis	R-HSA-5652227	7.903060e-01	0.102
Downregulation of ERBB4 signaling	R-HSA-1253288	7.903060e-01	0.102
TGFBR3 PTM regulation	R-HSA-9839383	7.903060e-01	0.102
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	7.903060e-01	0.102
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	7.903060e-01	0.102
Alpha-defensins	R-HSA-1462054	7.903060e-01	0.102
SARS-CoV Infections	R-HSA-9679506	7.919179e-01	0.101
PPARA activates gene expression	R-HSA-1989781	7.920048e-01	0.101
Gene Silencing by RNA	R-HSA-211000	7.929918e-01	0.101
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	7.953569e-01	0.099
Chromosome Maintenance	R-HSA-73886	7.968372e-01	0.099
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	7.976942e-01	0.098
SHC-mediated cascade:FGFR1	R-HSA-5654688	7.976942e-01	0.098
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	7.976942e-01	0.098
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	7.976942e-01	0.098
CD209 (DC-SIGN) signaling	R-HSA-5621575	7.976942e-01	0.098
GRB2 events in ERBB2 signaling	R-HSA-1963640	7.982191e-01	0.098
Translesion synthesis by POLK	R-HSA-5655862	7.982191e-01	0.098
Acetylcholine regulates insulin secretion	R-HSA-399997	7.982191e-01	0.098
Formation of xylulose-5-phosphate	R-HSA-5661270	7.982191e-01	0.098
Galactose catabolism	R-HSA-70370	7.982191e-01	0.098
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	7.982191e-01	0.098
Mitochondrial protein degradation	R-HSA-9837999	7.999655e-01	0.097
Cellular response to chemical stress	R-HSA-9711123	8.004201e-01	0.097
Selenocysteine synthesis	R-HSA-2408557	8.010811e-01	0.096
Cardiogenesis	R-HSA-9733709	8.027437e-01	0.095
GPER1 signaling	R-HSA-9634597	8.046036e-01	0.094
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	8.046036e-01	0.094
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	8.076555e-01	0.093
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	8.097817e-01	0.092
Resolution of Abasic Sites (AP sites)	R-HSA-73933	8.097817e-01	0.092
Transcriptional Regulation by VENTX	R-HSA-8853884	8.097817e-01	0.092
Switching of origins to a post-replicative state	R-HSA-69052	8.099996e-01	0.092
DNA Replication Pre-Initiation	R-HSA-69002	8.115526e-01	0.091
Cell junction organization	R-HSA-446728	8.150421e-01	0.089
FRS-mediated FGFR1 signaling	R-HSA-5654693	8.152269e-01	0.089
Polymerase switching on the C-strand of the telomere	R-HSA-174411	8.152269e-01	0.089
Integration of energy metabolism	R-HSA-163685	8.172384e-01	0.088
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	8.180618e-01	0.087
Miscellaneous transport and binding events	R-HSA-5223345	8.180618e-01	0.087
p75NTR regulates axonogenesis	R-HSA-193697	8.180764e-01	0.087
MASTL Facilitates Mitotic Progression	R-HSA-2465910	8.180764e-01	0.087
5-Phosphoribose 1-diphosphate biosynthesis	R-HSA-73843	8.180764e-01	0.087
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	8.180764e-01	0.087
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	8.180764e-01	0.087
Regulation of signaling by NODAL	R-HSA-1433617	8.180764e-01	0.087
Interleukin-1 processing	R-HSA-448706	8.180764e-01	0.087
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	8.187047e-01	0.087
Regulation of FZD by ubiquitination	R-HSA-4641263	8.187047e-01	0.087
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	8.187047e-01	0.087
Regulation of NPAS4 gene expression	R-HSA-9768759	8.187047e-01	0.087
Uptake and function of anthrax toxins	R-HSA-5210891	8.187047e-01	0.087
Viral mRNA Translation	R-HSA-192823	8.196777e-01	0.086
Ion channel transport	R-HSA-983712	8.233667e-01	0.084
Opioid Signalling	R-HSA-111885	8.284781e-01	0.082
Signaling by FGFR2 in disease	R-HSA-5655253	8.297385e-01	0.081
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	8.309047e-01	0.080
Adipogenesis	R-HSA-9843745	8.313375e-01	0.080
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	8.314519e-01	0.080
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	8.314519e-01	0.080
SARS-CoV-1 Infection	R-HSA-9678108	8.328504e-01	0.079
Cleavage of the damaged pyrimidine	R-HSA-110329	8.361882e-01	0.078
Depyrimidination	R-HSA-73928	8.361882e-01	0.078
Transcriptional regulation by RUNX3	R-HSA-8878159	8.371606e-01	0.077
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	8.373051e-01	0.077
Synaptic adhesion-like molecules	R-HSA-8849932	8.373051e-01	0.077
FGFR1 ligand binding and activation	R-HSA-190242	8.373051e-01	0.077
Mismatch Repair	R-HSA-5358508	8.373051e-01	0.077
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	8.373051e-01	0.077
UCH proteinases	R-HSA-5689603	8.406675e-01	0.075
Activation of NF-kappaB in B cells	R-HSA-1169091	8.413000e-01	0.075
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	R-HSA-629594	8.421705e-01	0.075
Pexophagy	R-HSA-9664873	8.421705e-01	0.075
Binding and entry of HIV virion	R-HSA-173107	8.421705e-01	0.075
TET1,2,3 and TDG demethylate DNA	R-HSA-5221030	8.421705e-01	0.075
EGFR Transactivation by Gastrin	R-HSA-2179392	8.421705e-01	0.075
Metabolism of serotonin	R-HSA-380612	8.421705e-01	0.075
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	8.421705e-01	0.075
Formation of intermediate mesoderm	R-HSA-9761174	8.421705e-01	0.075
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	8.421705e-01	0.075
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	8.421705e-01	0.075
Maturation of spike protein	R-HSA-9683686	8.421705e-01	0.075
Metal sequestration by antimicrobial proteins	R-HSA-6799990	8.421705e-01	0.075
Apoptosis induced DNA fragmentation	R-HSA-140342	8.421705e-01	0.075
SHC-mediated cascade:FGFR2	R-HSA-5654699	8.464365e-01	0.072
RNA Polymerase I Transcription Termination	R-HSA-73863	8.464365e-01	0.072
Sphingolipid de novo biosynthesis	R-HSA-1660661	8.470000e-01	0.072
Orc1 removal from chromatin	R-HSA-68949	8.522171e-01	0.069
RNA Polymerase I Promoter Escape	R-HSA-73772	8.522171e-01	0.069
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	8.522171e-01	0.069
Regulation of signaling by CBL	R-HSA-912631	8.541601e-01	0.068
E2F mediated regulation of DNA replication	R-HSA-113510	8.541601e-01	0.068
The NLRP3 inflammasome	R-HSA-844456	8.541601e-01	0.068
Crosslinking of collagen fibrils	R-HSA-2243919	8.541601e-01	0.068
Diseases of hemostasis	R-HSA-9671793	8.541601e-01	0.068
Pre-NOTCH Processing in Golgi	R-HSA-1912420	8.541601e-01	0.068
Collagen degradation	R-HSA-1442490	8.569715e-01	0.067
Vif-mediated degradation of APOBEC3G	R-HSA-180585	8.582170e-01	0.066
Triglyceride catabolism	R-HSA-163560	8.582170e-01	0.066
DAP12 interactions	R-HSA-2172127	8.595134e-01	0.066
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	8.602491e-01	0.065
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	8.602491e-01	0.065
FRS-mediated FGFR2 signaling	R-HSA-5654700	8.602491e-01	0.065
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	8.625110e-01	0.064
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	8.627885e-01	0.064
DAG1 core M3 glycosylations	R-HSA-8932505	8.630748e-01	0.064
Presynaptic depolarization and calcium channel opening	R-HSA-112308	8.630748e-01	0.064
LGI-ADAM interactions	R-HSA-5682910	8.630748e-01	0.064
FGFR2b ligand binding and activation	R-HSA-190377	8.630748e-01	0.064
vRNA Synthesis	R-HSA-192814	8.630748e-01	0.064
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	8.630748e-01	0.064
vRNP Assembly	R-HSA-192905	8.630748e-01	0.064
Cholesterol biosynthesis via desmosterol	R-HSA-6807047	8.630748e-01	0.064
Bicarbonate transporters	R-HSA-425381	8.630748e-01	0.064
Chylomicron assembly	R-HSA-8963888	8.630748e-01	0.064
Transport of RCbl within the body	R-HSA-9758890	8.630748e-01	0.064
Dissolution of Fibrin Clot	R-HSA-75205	8.630748e-01	0.064
HCMV Early Events	R-HSA-9609690	8.655064e-01	0.063
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	8.664078e-01	0.062
Signaling by PDGF	R-HSA-186797	8.664078e-01	0.062
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	8.671762e-01	0.062
Formation of ATP by chemiosmotic coupling	R-HSA-163210	8.694057e-01	0.061
Glycogen synthesis	R-HSA-3322077	8.694057e-01	0.061
Signaling by NODAL	R-HSA-1181150	8.694057e-01	0.061
Collagen chain trimerization	R-HSA-8948216	8.698072e-01	0.061
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	8.700925e-01	0.060
Nucleosome assembly	R-HSA-774815	8.700925e-01	0.060
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	8.700925e-01	0.060
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	8.700925e-01	0.060
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	8.700925e-01	0.060
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	8.707712e-01	0.060
Regulation of mitotic cell cycle	R-HSA-453276	8.707712e-01	0.060
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	8.707712e-01	0.060
NoRC negatively regulates rRNA expression	R-HSA-427413	8.707712e-01	0.060
Base-Excision Repair, AP Site Formation	R-HSA-73929	8.722040e-01	0.059
Beta-catenin independent WNT signaling	R-HSA-3858494	8.724656e-01	0.059
mRNA Capping	R-HSA-72086	8.729587e-01	0.059
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	8.753536e-01	0.058
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	8.790098e-01	0.056
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	8.805717e-01	0.055
Presynaptic nicotinic acetylcholine receptors	R-HSA-622323	8.812113e-01	0.055
PI3K events in ERBB4 signaling	R-HSA-1250342	8.812113e-01	0.055
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	8.812113e-01	0.055
Signaling by activated point mutants of FGFR1	R-HSA-1839122	8.812113e-01	0.055
ERKs are inactivated	R-HSA-202670	8.812113e-01	0.055
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	8.812113e-01	0.055
Lagging Strand Synthesis	R-HSA-69186	8.831725e-01	0.054
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	8.831725e-01	0.054
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	8.831725e-01	0.054
RNA Polymerase III Transcription Initiation	R-HSA-76046	8.846335e-01	0.053
Synthesis of PC	R-HSA-1483191	8.892358e-01	0.051
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	8.898795e-01	0.051
Stabilization of p53	R-HSA-69541	8.905541e-01	0.050
Plasma lipoprotein clearance	R-HSA-8964043	8.905541e-01	0.050
rRNA processing	R-HSA-72312	8.929277e-01	0.049
Downstream TCR signaling	R-HSA-202424	8.938622e-01	0.049
RNA Polymerase II Pre-transcription Events	R-HSA-674695	8.941874e-01	0.049
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.953407e-01	0.048
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	8.955847e-01	0.048
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	8.955847e-01	0.048
Assembly Of The HIV Virion	R-HSA-175474	8.955847e-01	0.048
Scavenging by Class F Receptors	R-HSA-3000484	8.969465e-01	0.047
Polymerase switching	R-HSA-69091	8.969465e-01	0.047
Leading Strand Synthesis	R-HSA-69109	8.969465e-01	0.047
GRB2 events in EGFR signaling	R-HSA-179812	8.969465e-01	0.047
Proline catabolism	R-HSA-70688	8.969465e-01	0.047
Diseases associated with surfactant metabolism	R-HSA-5687613	8.969465e-01	0.047
Trafficking and processing of endosomal TLR	R-HSA-1679131	8.969465e-01	0.047
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	8.969465e-01	0.047
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	8.969465e-01	0.047
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	8.969465e-01	0.047
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	8.969465e-01	0.047
Estrogen biosynthesis	R-HSA-193144	8.969465e-01	0.047
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	8.969465e-01	0.047
Adherens junctions interactions	R-HSA-418990	9.002472e-01	0.046
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.054317e-01	0.043
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	9.067595e-01	0.043
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	9.067595e-01	0.043
Fructose metabolism	R-HSA-5652084	9.067595e-01	0.043
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	9.067595e-01	0.043
Ethanol oxidation	R-HSA-71384	9.067595e-01	0.043
RAF-independent MAPK1/3 activation	R-HSA-112409	9.067595e-01	0.043
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	9.067595e-01	0.043
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	9.083454e-01	0.042
Acetylcholine binding and downstream events	R-HSA-181431	9.105982e-01	0.041
Postsynaptic nicotinic acetylcholine receptors	R-HSA-622327	9.105982e-01	0.041
Adenylate cyclase activating pathway	R-HSA-170660	9.105982e-01	0.041
FGFR2c ligand binding and activation	R-HSA-190375	9.105982e-01	0.041
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	9.105982e-01	0.041
FGFR4 ligand binding and activation	R-HSA-190322	9.105982e-01	0.041
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	9.105982e-01	0.041
Signaling by activated point mutants of FGFR3	R-HSA-1839130	9.105982e-01	0.041
PI5P Regulates TP53 Acetylation	R-HSA-6811555	9.105982e-01	0.041
Reversible hydration of carbon dioxide	R-HSA-1475029	9.105982e-01	0.041
FGFR3 mutant receptor activation	R-HSA-2033514	9.105982e-01	0.041
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	9.105982e-01	0.041
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	9.105982e-01	0.041
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.124709e-01	0.040
Regulation of beta-cell development	R-HSA-186712	9.124709e-01	0.040
Transcription of the HIV genome	R-HSA-167172	9.128017e-01	0.040
Regulation of RAS by GAPs	R-HSA-5658442	9.133787e-01	0.039
Translation of Structural Proteins	R-HSA-9683701	9.162388e-01	0.038
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	9.168068e-01	0.038
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	9.168068e-01	0.038
Regulation of PTEN mRNA translation	R-HSA-8943723	9.168068e-01	0.038
Organic anion transport by SLCO transporters	R-HSA-879518	9.168068e-01	0.038
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	9.168068e-01	0.038
GABA receptor activation	R-HSA-977443	9.190504e-01	0.037
RNA Polymerase I Transcription	R-HSA-73864	9.197789e-01	0.036
Developmental Cell Lineages	R-HSA-9734767	9.204201e-01	0.036
Protein localization	R-HSA-9609507	9.221377e-01	0.035
Glucagon signaling in metabolic regulation	R-HSA-163359	9.222988e-01	0.035
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	9.224420e-01	0.035
Removal of the Flap Intermediate	R-HSA-69166	9.224420e-01	0.035
FGFR3c ligand binding and activation	R-HSA-190372	9.224420e-01	0.035
Transport of fatty acids	R-HSA-804914	9.224420e-01	0.035
Hydrolysis of LPC	R-HSA-1483115	9.224420e-01	0.035
cGMP effects	R-HSA-418457	9.224420e-01	0.035
HDL assembly	R-HSA-8963896	9.224420e-01	0.035
Collagen formation	R-HSA-1474290	9.227899e-01	0.035
Ribosome-associated quality control	R-HSA-9948299	9.242088e-01	0.034
Aquaporin-mediated transport	R-HSA-445717	9.251934e-01	0.034
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	9.258293e-01	0.033
Plasma lipoprotein assembly	R-HSA-8963898	9.258293e-01	0.033
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.267834e-01	0.033
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	9.267834e-01	0.033
Uptake and actions of bacterial toxins	R-HSA-5339562	9.267834e-01	0.033
HCMV Infection	R-HSA-9609646	9.293610e-01	0.032
eNOS activation	R-HSA-203615	9.297658e-01	0.032
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.297658e-01	0.032
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.297658e-01	0.032
Response of Mtb to phagocytosis	R-HSA-9637690	9.302246e-01	0.031
Adenylate cyclase inhibitory pathway	R-HSA-170670	9.327174e-01	0.030
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	9.327174e-01	0.030
G beta:gamma signalling through BTK	R-HSA-8964315	9.327174e-01	0.030
Processive synthesis on the lagging strand	R-HSA-69183	9.327174e-01	0.030
p38MAPK events	R-HSA-171007	9.327174e-01	0.030
FGFR3 ligand binding and activation	R-HSA-190239	9.327174e-01	0.030
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	9.327174e-01	0.030
Protein lipoylation	R-HSA-9857492	9.327174e-01	0.030
Lysosphingolipid and LPA receptors	R-HSA-419408	9.327174e-01	0.030
DNA Damage Reversal	R-HSA-73942	9.327174e-01	0.030
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	9.327673e-01	0.030
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	9.339220e-01	0.030
Activation of G protein gated Potassium channels	R-HSA-1296041	9.339220e-01	0.030
G protein gated Potassium channels	R-HSA-1296059	9.339220e-01	0.030
Laminin interactions	R-HSA-3000157	9.339220e-01	0.030
Glycogen breakdown (glycogenolysis)	R-HSA-70221	9.339220e-01	0.030
Formation of the nephric duct	R-HSA-9830364	9.339220e-01	0.030
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	9.363943e-01	0.029
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	9.383100e-01	0.028
Base Excision Repair	R-HSA-73884	9.401275e-01	0.027
Urea cycle	R-HSA-70635	9.411729e-01	0.026
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	9.411729e-01	0.026
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.411729e-01	0.026
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	9.416320e-01	0.026
Defective GALNT12 causes CRCS1	R-HSA-5083636	9.416320e-01	0.026
Defective GALNT3 causes HFTC	R-HSA-5083625	9.416320e-01	0.026
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	9.416320e-01	0.026
Regulation of BACH1 activity	R-HSA-9708530	9.416320e-01	0.026
Fructose catabolism	R-HSA-70350	9.416320e-01	0.026
Induction of Cell-Cell Fusion	R-HSA-9733458	9.416320e-01	0.026
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	9.416320e-01	0.026
Attachment and Entry	R-HSA-9678110	9.416320e-01	0.026
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	9.427554e-01	0.026
RNA Polymerase III Transcription	R-HSA-74158	9.427554e-01	0.026
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	9.427554e-01	0.026
FGFR2 mutant receptor activation	R-HSA-1839126	9.427554e-01	0.026
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.427554e-01	0.026
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	9.434384e-01	0.025
Cytoprotection by HMOX1	R-HSA-9707564	9.441222e-01	0.025
Regulation of insulin secretion	R-HSA-422356	9.446980e-01	0.025
Signaling by NOTCH	R-HSA-157118	9.459396e-01	0.024
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	9.472692e-01	0.024
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	9.476630e-01	0.023
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.476630e-01	0.023
Signaling by BMP	R-HSA-201451	9.476630e-01	0.023
Insulin processing	R-HSA-264876	9.476630e-01	0.023
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	R-HSA-83936	9.476630e-01	0.023
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.481787e-01	0.023
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	9.483792e-01	0.023
Degradation of DVL	R-HSA-4641258	9.483792e-01	0.023
Synthesis of DNA	R-HSA-69239	9.489809e-01	0.023
SHC1 events in ERBB4 signaling	R-HSA-1250347	9.493659e-01	0.023
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	9.493659e-01	0.023
Biosynthesis of maresin-like SPMs	R-HSA-9027307	9.493659e-01	0.023
Heme assimilation	R-HSA-9927020	9.493659e-01	0.023
Phase 2 - plateau phase	R-HSA-5576893	9.493659e-01	0.023
Passive transport by Aquaporins	R-HSA-432047	9.493659e-01	0.023
Disorders of Developmental Biology	R-HSA-9675151	9.493659e-01	0.023
Coenzyme A biosynthesis	R-HSA-196783	9.493659e-01	0.023
tRNA modification in the mitochondrion	R-HSA-6787450	9.493659e-01	0.023
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	9.520423e-01	0.021
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	9.520423e-01	0.021
RNA Polymerase I Promoter Clearance	R-HSA-73854	9.526321e-01	0.021
Inflammasomes	R-HSA-622312	9.534665e-01	0.021
Elastic fibre formation	R-HSA-1566948	9.534846e-01	0.021
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.553676e-01	0.020
C-type lectin receptors (CLRs)	R-HSA-5621481	9.559812e-01	0.020
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	9.560754e-01	0.020
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	9.560754e-01	0.020
Glycogen storage diseases	R-HSA-3229121	9.560754e-01	0.020
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	9.560754e-01	0.020
Catecholamine biosynthesis	R-HSA-209905	9.560754e-01	0.020
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.581148e-01	0.019
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.586514e-01	0.018
Triglyceride metabolism	R-HSA-8979227	9.603151e-01	0.018
HCMV Late Events	R-HSA-9610379	9.605444e-01	0.017
G beta:gamma signalling through PLC beta	R-HSA-418217	9.618961e-01	0.017
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	9.618961e-01	0.017
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	9.618961e-01	0.017
Activated point mutants of FGFR2	R-HSA-2033519	9.618961e-01	0.017
Presynaptic function of Kainate receptors	R-HSA-500657	9.618961e-01	0.017
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.623098e-01	0.017
Negative regulation of NOTCH4 signaling	R-HSA-9604323	9.623098e-01	0.017
Glycogen metabolism	R-HSA-8982491	9.623098e-01	0.017
Generation of second messenger molecules	R-HSA-202433	9.623098e-01	0.017
Nuclear signaling by ERBB4	R-HSA-1251985	9.623098e-01	0.017
Neurotransmitter clearance	R-HSA-112311	9.632797e-01	0.016
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	9.644002e-01	0.016
COPII-mediated vesicle transport	R-HSA-204005	9.644002e-01	0.016
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.661071e-01	0.015
Maturation of spike protein	R-HSA-9694548	9.661071e-01	0.015
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	9.669459e-01	0.015
Pyrimidine biosynthesis	R-HSA-500753	9.669459e-01	0.015
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	9.669459e-01	0.015
O2/CO2 exchange in erythrocytes	R-HSA-1480926	9.669459e-01	0.015
HDL remodeling	R-HSA-8964058	9.669459e-01	0.015
Hedgehog 'on' state	R-HSA-5632684	9.673282e-01	0.014
Cargo concentration in the ER	R-HSA-5694530	9.674078e-01	0.014
Aspartate and asparagine metabolism	R-HSA-8963693	9.674078e-01	0.014
Cell-cell junction organization	R-HSA-421270	9.679410e-01	0.014
Degradation of GLI2 by the proteasome	R-HSA-5610783	9.695411e-01	0.013
Degradation of GLI1 by the proteasome	R-HSA-5610780	9.695411e-01	0.013
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.695411e-01	0.013
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.695635e-01	0.013
DNA Replication	R-HSA-69306	9.700571e-01	0.013
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.713266e-01	0.013
Acyl chain remodelling of PI	R-HSA-1482922	9.713266e-01	0.013
Creatine metabolism	R-HSA-71288	9.713266e-01	0.013
Common Pathway of Fibrin Clot Formation	R-HSA-140875	9.713266e-01	0.013
Protein hydroxylation	R-HSA-9629569	9.713266e-01	0.013
Eicosanoid ligand-binding receptors	R-HSA-391903	9.713266e-01	0.013
Pre-NOTCH Transcription and Translation	R-HSA-1912408	9.719801e-01	0.012
Activation of GABAB receptors	R-HSA-991365	9.726441e-01	0.012
GABA B receptor activation	R-HSA-977444	9.726441e-01	0.012
RNA Polymerase I Transcription Initiation	R-HSA-73762	9.726441e-01	0.012
Viral Infection Pathways	R-HSA-9824446	9.738692e-01	0.011
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.743637e-01	0.011
FGFR2 ligand binding and activation	R-HSA-190241	9.751270e-01	0.011
Matriglycan biosynthesis on DAG1	R-HSA-9939291	9.751270e-01	0.011
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	9.751270e-01	0.011
Basigin interactions	R-HSA-210991	9.751270e-01	0.011
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	9.751270e-01	0.011
ABC-family proteins mediated transport	R-HSA-382556	9.752865e-01	0.011
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	9.757844e-01	0.011
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.761155e-01	0.010
Cellular response to hypoxia	R-HSA-1234174	9.771337e-01	0.010
Vpu mediated degradation of CD4	R-HSA-180534	9.772800e-01	0.010
Acyl chain remodelling of PC	R-HSA-1482788	9.772800e-01	0.010
Heme degradation	R-HSA-189483	9.772800e-01	0.010
Gastrulation	R-HSA-9758941	9.778580e-01	0.010
Androgen biosynthesis	R-HSA-193048	9.784239e-01	0.009
Molybdenum cofactor biosynthesis	R-HSA-947581	9.784239e-01	0.009
Serine metabolism	R-HSA-977347	9.784239e-01	0.009
Glucocorticoid biosynthesis	R-HSA-194002	9.784239e-01	0.009
Glutathione synthesis and recycling	R-HSA-174403	9.784239e-01	0.009
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	9.784239e-01	0.009
Attachment and Entry	R-HSA-9694614	9.784239e-01	0.009
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	9.798738e-01	0.009
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	9.798738e-01	0.009
RA biosynthesis pathway	R-HSA-5365859	9.798738e-01	0.009
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.802512e-01	0.009
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.802512e-01	0.009
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.802512e-01	0.009
Developmental Biology	R-HSA-1266738	9.804235e-01	0.009
Translation of Structural Proteins	R-HSA-9694635	9.807205e-01	0.008
Metabolism of steroid hormones	R-HSA-196071	9.810635e-01	0.008
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.812839e-01	0.008
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.812839e-01	0.008
Cellular hexose transport	R-HSA-189200	9.812839e-01	0.008
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	9.821794e-01	0.008
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	9.821794e-01	0.008
Acyl chain remodelling of PE	R-HSA-1482839	9.821794e-01	0.008
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.821794e-01	0.008
Regulation of pyruvate metabolism	R-HSA-9861718	9.823034e-01	0.008
Integrin cell surface interactions	R-HSA-216083	9.823779e-01	0.008
PCP/CE pathway	R-HSA-4086400	9.823779e-01	0.008
Pre-NOTCH Expression and Processing	R-HSA-1912422	9.826765e-01	0.008
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.827819e-01	0.008
Termination of O-glycan biosynthesis	R-HSA-977068	9.837650e-01	0.007
Free fatty acids regulate insulin secretion	R-HSA-400451	9.837650e-01	0.007
Biosynthesis of maresins	R-HSA-9018682	9.837650e-01	0.007
Carnitine shuttle	R-HSA-200425	9.837650e-01	0.007
ABC transporters in lipid homeostasis	R-HSA-1369062	9.837650e-01	0.007
G alpha (s) signalling events	R-HSA-418555	9.842602e-01	0.007
Peroxisomal protein import	R-HSA-9033241	9.854053e-01	0.006
Plasma lipoprotein remodeling	R-HSA-8963899	9.858123e-01	0.006
CYP2E1 reactions	R-HSA-211999	9.859173e-01	0.006
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	9.859173e-01	0.006
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.859173e-01	0.006
Mitochondrial RNA degradation	R-HSA-9836573	9.859173e-01	0.006
TNFs bind their physiological receptors	R-HSA-5669034	9.859173e-01	0.006
Degradation of AXIN	R-HSA-4641257	9.860460e-01	0.006
SLC-mediated transport of organic cations	R-HSA-549127	9.860460e-01	0.006
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.860460e-01	0.006
Metabolism of folate and pterines	R-HSA-196757	9.860460e-01	0.006
Post-translational protein phosphorylation	R-HSA-8957275	9.865641e-01	0.006
Signaling by Retinoic Acid	R-HSA-5362517	9.868323e-01	0.006
Degradation of CDH1	R-HSA-9766229	9.873060e-01	0.006
Chemokine receptors bind chemokines	R-HSA-380108	9.873060e-01	0.006
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.877843e-01	0.005
Tight junction interactions	R-HSA-420029	9.877843e-01	0.005
Alpha-oxidation of phytanate	R-HSA-389599	9.877843e-01	0.005
VEGFR2 mediated cell proliferation	R-HSA-5218921	9.877843e-01	0.005
Acyl chain remodelling of PS	R-HSA-1482801	9.877843e-01	0.005
Beta-oxidation of pristanoyl-CoA	R-HSA-389887	9.877843e-01	0.005
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.877843e-01	0.005
Formation of paraxial mesoderm	R-HSA-9793380	9.881259e-01	0.005
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.890908e-01	0.005
Pentose phosphate pathway	R-HSA-71336	9.890908e-01	0.005
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.890908e-01	0.005
MET activates PTK2 signaling	R-HSA-8874081	9.894040e-01	0.005
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.894040e-01	0.005
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	9.894040e-01	0.005
Suppression of phagosomal maturation	R-HSA-9637687	9.894040e-01	0.005
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.895952e-01	0.005
Neddylation	R-HSA-8951664	9.898197e-01	0.004
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.898526e-01	0.004
Hedgehog ligand biogenesis	R-HSA-5358346	9.898526e-01	0.004
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.902633e-01	0.004
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	9.903595e-01	0.004
Regulation of RUNX3 expression and activity	R-HSA-8941858	9.903595e-01	0.004
Signaling by NOTCH4	R-HSA-9013694	9.903771e-01	0.004
Triglyceride biosynthesis	R-HSA-75109	9.908089e-01	0.004
Synthesis of PE	R-HSA-1483213	9.908089e-01	0.004
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.908089e-01	0.004
Maturation of hRSV A proteins	R-HSA-9828806	9.908089e-01	0.004
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	9.909336e-01	0.004
Protein ubiquitination	R-HSA-8852135	9.912817e-01	0.004
Citric acid cycle (TCA cycle)	R-HSA-71403	9.912817e-01	0.004
CD22 mediated BCR regulation	R-HSA-5690714	9.913185e-01	0.004
Hh mutants are degraded by ERAD	R-HSA-5362768	9.914837e-01	0.004
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	9.914837e-01	0.004
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.914837e-01	0.004
Nucleotide biosynthesis	R-HSA-8956320	9.919030e-01	0.004
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.920277e-01	0.003
Insulin receptor recycling	R-HSA-77387	9.920277e-01	0.003
Degradation of CRY and PER proteins	R-HSA-9932298	9.924793e-01	0.003
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	9.924793e-01	0.003
HIV Transcription Initiation	R-HSA-167161	9.924793e-01	0.003
RNA Polymerase II Transcription Initiation	R-HSA-75953	9.924793e-01	0.003
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	9.924793e-01	0.003
Scavenging by Class A Receptors	R-HSA-3000480	9.924793e-01	0.003
Pyruvate metabolism	R-HSA-70268	9.930250e-01	0.003
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.930849e-01	0.003
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.933607e-01	0.003
G alpha (z) signalling events	R-HSA-418597	9.935501e-01	0.003
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.940020e-01	0.003
RNA Polymerase II Promoter Escape	R-HSA-73776	9.941406e-01	0.003
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.941406e-01	0.003
ER-Phagosome pathway	R-HSA-1236974	9.942377e-01	0.003
Metabolism of amine-derived hormones	R-HSA-209776	9.942469e-01	0.003
Neurotransmitter release cycle	R-HSA-112310	9.947660e-01	0.002
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	9.947974e-01	0.002
Molecules associated with elastic fibres	R-HSA-2129379	9.947974e-01	0.002
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	9.947974e-01	0.002
Proteasome assembly	R-HSA-9907900	9.948306e-01	0.002
Surfactant metabolism	R-HSA-5683826	9.948306e-01	0.002
Regulation of CDH1 Function	R-HSA-9764561	9.948705e-01	0.002
Amyloid fiber formation	R-HSA-977225	9.952240e-01	0.002
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.954159e-01	0.002
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.954406e-01	0.002
Somitogenesis	R-HSA-9824272	9.954406e-01	0.002
Asymmetric localization of PCP proteins	R-HSA-4608870	9.954406e-01	0.002
DAG1 glycosylations	R-HSA-8931838	9.954875e-01	0.002
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.954875e-01	0.002
ECM proteoglycans	R-HSA-3000178	9.958848e-01	0.002
Retinoid metabolism and transport	R-HSA-975634	9.958848e-01	0.002
Metabolism of cofactors	R-HSA-8978934	9.958848e-01	0.002
Amino acid transport across the plasma membrane	R-HSA-352230	9.959268e-01	0.002
Selenoamino acid metabolism	R-HSA-2408522	9.959767e-01	0.002
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.959798e-01	0.002
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.959798e-01	0.002
Recycling of bile acids and salts	R-HSA-159418	9.960860e-01	0.002
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.963072e-01	0.002
G alpha (q) signalling events	R-HSA-416476	9.963310e-01	0.002
Glutathione conjugation	R-HSA-156590	9.963724e-01	0.002
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.964119e-01	0.002
Endogenous sterols	R-HSA-211976	9.967703e-01	0.001
Signal amplification	R-HSA-392518	9.970555e-01	0.001
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	9.970555e-01	0.001
Signaling by NOTCH2	R-HSA-1980145	9.970555e-01	0.001
Calnexin/calreticulin cycle	R-HSA-901042	9.970555e-01	0.001
NCAM signaling for neurite out-growth	R-HSA-375165	9.971256e-01	0.001
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.972383e-01	0.001
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.972485e-01	0.001
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.973326e-01	0.001
Regulation of Apoptosis	R-HSA-169911	9.974462e-01	0.001
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	R-HSA-193775	9.974462e-01	0.001
Glycosphingolipid transport	R-HSA-9845576	9.977850e-01	0.001
Antigen processing-Cross presentation	R-HSA-1236975	9.980414e-01	0.001
ABC transporter disorders	R-HSA-5619084	9.980869e-01	0.001
Cholesterol biosynthesis	R-HSA-191273	9.980869e-01	0.001
Synthesis of bile acids and bile salts	R-HSA-192105	9.982300e-01	0.001
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.982877e-01	0.001
Purine salvage	R-HSA-74217	9.983338e-01	0.001
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.983338e-01	0.001
Bile acid and bile salt metabolism	R-HSA-194068	9.983857e-01	0.001
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.984029e-01	0.001
SLC-mediated transport of amino acids	R-HSA-9958863	9.984029e-01	0.001
GPCR downstream signalling	R-HSA-388396	9.984145e-01	0.001
SLC transporter disorders	R-HSA-5619102	9.985205e-01	0.001
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.985549e-01	0.001
Metabolism of steroids	R-HSA-8957322	9.986096e-01	0.001
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.986295e-01	0.001
Paracetamol ADME	R-HSA-9753281	9.987197e-01	0.001
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	9.987466e-01	0.001
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	9.987466e-01	0.001
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.989046e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.989431e-01	0.000
Dectin-2 family	R-HSA-5621480	9.990096e-01	0.000
Synthesis of PA	R-HSA-1483166	9.990096e-01	0.000
Cytosolic tRNA aminoacylation	R-HSA-379716	9.991824e-01	0.000
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.991882e-01	0.000
Diseases of carbohydrate metabolism	R-HSA-5663084	9.992187e-01	0.000
Defensins	R-HSA-1461973	9.992909e-01	0.000
Synthesis of very long-chain fatty acyl-CoAs	R-HSA-75876	9.992909e-01	0.000
Pyrimidine catabolism	R-HSA-73621	9.992909e-01	0.000
Transport of vitamins, nucleosides, and related molecules	R-HSA-425397	9.993071e-01	0.000
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.993850e-01	0.000
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.993850e-01	0.000
Complex I biogenesis	R-HSA-6799198	9.995437e-01	0.000
Interleukin-10 signaling	R-HSA-6783783	9.995725e-01	0.000
FCERI mediated MAPK activation	R-HSA-2871796	9.995811e-01	0.000
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.995989e-01	0.000
Xenobiotics	R-HSA-211981	9.995993e-01	0.000
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.996214e-01	0.000
Formation of the cornified envelope	R-HSA-6809371	9.996721e-01	0.000
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.996911e-01	0.000
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.996983e-01	0.000
FCERI mediated NF-kB activation	R-HSA-2871837	9.997177e-01	0.000
Nicotinate metabolism	R-HSA-196807	9.997288e-01	0.000
Kidney development	R-HSA-9830369	9.997288e-01	0.000
Extracellular matrix organization	R-HSA-1474244	9.997357e-01	0.000
Azathioprine ADME	R-HSA-9748787	9.997384e-01	0.000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.997384e-01	0.000
O-linked glycosylation of mucins	R-HSA-913709	9.997620e-01	0.000
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.997789e-01	0.000
Innate Immune System	R-HSA-168249	9.997937e-01	0.000
tRNA processing	R-HSA-72306	9.998279e-01	0.000
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.998392e-01	0.000
Metabolism of porphyrins	R-HSA-189445	9.998392e-01	0.000
Parasite infection	R-HSA-9664407	9.998471e-01	0.000
Leishmania phagocytosis	R-HSA-9664417	9.998471e-01	0.000
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.998471e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.998477e-01	0.000
Purine catabolism	R-HSA-74259	9.998590e-01	0.000
Digestion	R-HSA-8935690	9.998887e-01	0.000
Signaling by GPCR	R-HSA-372790	9.998898e-01	0.000
ROS and RNS production in phagocytes	R-HSA-1222556	9.998915e-01	0.000
SLC-mediated transport of organic anions	R-HSA-9955298	9.999359e-01	0.000
tRNA Aminoacylation	R-HSA-379724	9.999371e-01	0.000
Metabolism of polyamines	R-HSA-351202	9.999371e-01	0.000
Nucleotide salvage	R-HSA-8956321	9.999454e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.999501e-01	0.000
Translation	R-HSA-72766	9.999527e-01	0.000
Disorders of transmembrane transporters	R-HSA-5619115	9.999548e-01	0.000
Digestion and absorption	R-HSA-8963743	9.999590e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.999680e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.999710e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999837e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.999842e-01	0.000
Parasitic Infection Pathways	R-HSA-9824443	9.999857e-01	0.000
Leishmania infection	R-HSA-9658195	9.999857e-01	0.000
Metal ion assimilation from the host	R-HSA-9638482	9.999869e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999872e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999877e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.999886e-01	0.000
Aspirin ADME	R-HSA-9749641	9.999901e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999916e-01	0.000
Iron uptake and transport	R-HSA-917937	9.999926e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999938e-01	0.000
Asparagine N-linked glycosylation	R-HSA-446203	9.999949e-01	0.000
Scavenging of heme from plasma	R-HSA-2168880	9.999955e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999958e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999958e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.999961e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999962e-01	0.000
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.999969e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.999970e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999985e-01	0.000
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.999987e-01	0.000
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999988e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999991e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.999991e-01	0.000
Post-translational protein modification	R-HSA-597592	9.999992e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999994e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999994e-01	0.000
Transport of small molecules	R-HSA-382551	9.999994e-01	0.000
Regulation of Complement cascade	R-HSA-977606	9.999995e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999999e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999999e-01	0.000
Disease	R-HSA-1643685	9.999999e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999999e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.999999e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.999999e-01	0.000
Sphingolipid metabolism	R-HSA-428157	1.000000e+00	0.000
Nucleotide catabolism	R-HSA-8956319	1.000000e+00	0.000
Complement cascade	R-HSA-166658	1.000000e+00	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Keratinization	R-HSA-6805567	1.000000e+00	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	1.000000e+00	0.000
Infectious disease	R-HSA-5663205	1.000000e+00	0.000
Initial triggering of complement	R-HSA-166663	1.000000e+00	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
Mitochondrial translation	R-HSA-5368287	1.000000e+00	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000
Sensory perception of taste	R-HSA-9717189	1.000000e+00	0.000
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000e+00	0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Drug ADME	R-HSA-9748784	1.000000e+00	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Cellular response to heat stress	R-HSA-3371556	5.995204e-15	14.222
HSF1-dependent transactivation	R-HSA-3371571	5.995204e-14	13.222
Attenuation phase	R-HSA-3371568	3.236300e-13	12.490
Cellular responses to stress	R-HSA-2262752	7.241985e-13	12.140
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	3.841705e-12	11.415
Cellular responses to stimuli	R-HSA-8953897	1.951550e-11	10.710
Cell Cycle	R-HSA-1640170	1.724940e-09	8.763
HSF1 activation	R-HSA-3371511	2.258069e-09	8.646
Apoptotic execution phase	R-HSA-75153	5.020277e-09	8.299
M Phase	R-HSA-68886	1.143673e-08	7.942
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	2.053523e-08	7.688
Cell Cycle, Mitotic	R-HSA-69278	2.317754e-08	7.635
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	6.149640e-08	7.211
Mitotic Anaphase	R-HSA-68882	9.877052e-08	7.005
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.120387e-07	6.951
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	3.873876e-07	6.412
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	8.513233e-07	6.070
Mitotic Prometaphase	R-HSA-68877	8.747327e-07	6.058
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	1.155529e-06	5.937
Separation of Sister Chromatids	R-HSA-2467813	1.528295e-06	5.816
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	1.865748e-06	5.729
PKR-mediated signaling	R-HSA-9833482	2.053391e-06	5.688
Membrane Trafficking	R-HSA-199991	2.527391e-06	5.597
Apoptotic cleavage of cellular proteins	R-HSA-111465	5.461470e-06	5.263
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	6.357049e-06	5.197
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	7.131385e-06	5.147
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	8.617188e-06	5.065
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	1.144763e-05	4.941
Nervous system development	R-HSA-9675108	1.287201e-05	4.890
Aggrephagy	R-HSA-9646399	1.643335e-05	4.784
Transport of connexons to the plasma membrane	R-HSA-190872	1.715121e-05	4.766
Autophagy	R-HSA-9612973	1.768341e-05	4.752
Axon guidance	R-HSA-422475	1.746307e-05	4.758
Interferon Signaling	R-HSA-913531	2.042616e-05	4.690
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	2.409690e-05	4.618
Signaling downstream of RAS mutants	R-HSA-9649948	2.409690e-05	4.618
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	2.409690e-05	4.618
Signaling by RAS mutants	R-HSA-6802949	2.409690e-05	4.618
Signaling by RAF1 mutants	R-HSA-9656223	2.692419e-05	4.570
Recycling pathway of L1	R-HSA-437239	3.018301e-05	4.520
Eukaryotic Translation Initiation	R-HSA-72613	3.052651e-05	4.515
Cap-dependent Translation Initiation	R-HSA-72737	3.052651e-05	4.515
Activation of AMPK downstream of NMDARs	R-HSA-9619483	3.114144e-05	4.507
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	3.398626e-05	4.469
Post-chaperonin tubulin folding pathway	R-HSA-389977	3.623730e-05	4.441
Translation initiation complex formation	R-HSA-72649	3.979209e-05	4.400
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	4.261015e-05	4.370
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	4.565404e-05	4.341
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	4.890353e-05	4.311
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	4.890353e-05	4.311
Interleukin-12 family signaling	R-HSA-447115	6.934432e-05	4.159
Macroautophagy	R-HSA-1632852	7.407881e-05	4.130
Interleukin-12 signaling	R-HSA-9020591	7.884806e-05	4.103
SARS-CoV-2-host interactions	R-HSA-9705683	8.120260e-05	4.090
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	8.663306e-05	4.062
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	1.017351e-04	3.993
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.090268e-04	3.962
Transport of the SLBP independent Mature mRNA	R-HSA-159227	1.209501e-04	3.917
Oncogenic MAPK signaling	R-HSA-6802957	1.175952e-04	3.930
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	1.209501e-04	3.917
Kinesins	R-HSA-983189	1.246564e-04	3.904
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.353878e-04	3.868
Gap junction trafficking and regulation	R-HSA-157858	1.517239e-04	3.819
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	1.543640e-04	3.811
Programmed Cell Death	R-HSA-5357801	1.603434e-04	3.795
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.686750e-04	3.773
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	1.711901e-04	3.767
Post NMDA receptor activation events	R-HSA-438064	1.819129e-04	3.740
Gap junction trafficking	R-HSA-190828	1.806511e-04	3.743
Signal Transduction	R-HSA-162582	1.783420e-04	3.749
Ribosomal scanning and start codon recognition	R-HSA-72702	1.821054e-04	3.740
ISG15 antiviral mechanism	R-HSA-1169408	1.852796e-04	3.732
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	1.988941e-04	3.701
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	2.123772e-04	3.673
Interactions of Rev with host cellular proteins	R-HSA-177243	2.123772e-04	3.673
Nuclear Envelope Breakdown	R-HSA-2980766	2.174097e-04	3.663
Influenza Infection	R-HSA-168255	2.199520e-04	3.658
Mitotic Spindle Checkpoint	R-HSA-69618	2.217419e-04	3.654
PKMTs methylate histone lysines	R-HSA-3214841	2.618219e-04	3.582
Mitotic Prophase	R-HSA-68875	2.805281e-04	3.552
Apoptosis induced DNA fragmentation	R-HSA-140342	2.841778e-04	3.546
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	2.857016e-04	3.544
Metabolism of non-coding RNA	R-HSA-194441	3.062327e-04	3.514
snRNP Assembly	R-HSA-191859	3.062327e-04	3.514
MAP2K and MAPK activation	R-HSA-5674135	3.208388e-04	3.494
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	3.209544e-04	3.494
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	3.498373e-04	3.456
Amplification of signal from the kinetochores	R-HSA-141424	3.498373e-04	3.456
Apoptosis	R-HSA-109581	3.409018e-04	3.467
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	3.637824e-04	3.439
Protein folding	R-HSA-391251	4.089617e-04	3.388
Cohesin Loading onto Chromatin	R-HSA-2470946	4.375262e-04	3.359
Nonsense-Mediated Decay (NMD)	R-HSA-927802	4.577351e-04	3.339
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	4.577351e-04	3.339
ChREBP activates metabolic gene expression	R-HSA-163765	4.403989e-04	3.356
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	4.665427e-04	3.331
Signaling by ROBO receptors	R-HSA-376176	4.675912e-04	3.330
Selective autophagy	R-HSA-9663891	5.212116e-04	3.283
Glycolysis	R-HSA-70171	5.264109e-04	3.279
Transcriptional Regulation by E2F6	R-HSA-8953750	5.703320e-04	3.244
NS1 Mediated Effects on Host Pathways	R-HSA-168276	5.703320e-04	3.244
Golgi-to-ER retrograde transport	R-HSA-8856688	5.768124e-04	3.239
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	6.048990e-04	3.218
Late endosomal microautophagy	R-HSA-9615710	6.323216e-04	3.199
RAF activation	R-HSA-5673000	6.782516e-04	3.169
Formation of a pool of free 40S subunits	R-HSA-72689	6.727351e-04	3.172
Mitotic Telophase/Cytokinesis	R-HSA-68884	6.585777e-04	3.181
Nuclear import of Rev protein	R-HSA-180746	6.782516e-04	3.169
Gap junction assembly	R-HSA-190861	6.782516e-04	3.169
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	6.405297e-04	3.193
Influenza Viral RNA Transcription and Replication	R-HSA-168273	7.287002e-04	3.137
COPI-mediated anterograde transport	R-HSA-6807878	7.581400e-04	3.120
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	7.927257e-04	3.101
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	8.165105e-04	3.088
Metabolism of RNA	R-HSA-8953854	8.531860e-04	3.069
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	8.601659e-04	3.065
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	9.854908e-04	3.006
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	9.854908e-04	3.006
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	9.443163e-04	3.025
Cellular Senescence	R-HSA-2559583	9.287461e-04	3.032
Chaperonin-mediated protein folding	R-HSA-390466	1.100433e-03	2.958
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	1.142501e-03	2.942
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.173344e-03	2.931
Vpr-mediated nuclear import of PICs	R-HSA-180910	1.229345e-03	2.910
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	1.241580e-03	2.906
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	1.253330e-03	2.902
IPs transport between nucleus and cytosol	R-HSA-1855170	1.487713e-03	2.827
Cell Cycle Checkpoints	R-HSA-69620	1.492502e-03	2.826
Cytokine Signaling in Immune system	R-HSA-1280215	1.531677e-03	2.815
Vesicle-mediated transport	R-HSA-5653656	1.742108e-03	2.759
Transcriptional Regulation by MECP2	R-HSA-8986944	1.761322e-03	2.754
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	1.785892e-03	2.748
Cargo trafficking to the periciliary membrane	R-HSA-5620920	1.795233e-03	2.746
Striated Muscle Contraction	R-HSA-390522	1.808031e-03	2.743
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	1.808031e-03	2.743
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.822129e-03	2.739
L1CAM interactions	R-HSA-373760	1.870394e-03	2.728
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.950185e-03	2.710
Eukaryotic Translation Elongation	R-HSA-156842	2.201852e-03	2.657
Interactions of Vpr with host cellular proteins	R-HSA-176033	2.108344e-03	2.676
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	2.297911e-03	2.639
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	2.330887e-03	2.632
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	2.617374e-03	2.582
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	2.771416e-03	2.557
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	2.858129e-03	2.544
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	3.272816e-03	2.485
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	3.893679e-03	2.410
Meiosis	R-HSA-1500620	4.046503e-03	2.393
Chromatin organization	R-HSA-4839726	4.116212e-03	2.386
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	3.907769e-03	2.408
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	3.812375e-03	2.419
Semaphorin interactions	R-HSA-373755	3.812375e-03	2.419
Glucose metabolism	R-HSA-70326	4.174303e-03	2.379
Regulation of CDH1 Gene Transcription	R-HSA-9764560	3.792907e-03	2.421
Signaling by MRAS-complex mutants	R-HSA-9660537	4.264302e-03	2.370
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	4.264302e-03	2.370
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	4.264302e-03	2.370
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	4.270777e-03	2.369
HCMV Infection	R-HSA-9609646	4.371304e-03	2.359
Chromatin modifying enzymes	R-HSA-3247509	4.607909e-03	2.336
Regulation of MECP2 expression and activity	R-HSA-9022692	4.629593e-03	2.334
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	4.710904e-03	2.327
MAPK family signaling cascades	R-HSA-5683057	4.950389e-03	2.305
ER to Golgi Anterograde Transport	R-HSA-199977	5.124084e-03	2.290
SARS-CoV-1-host interactions	R-HSA-9692914	5.180433e-03	2.286
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	5.394784e-03	2.268
SARS-CoV-2 Infection	R-HSA-9694516	5.469193e-03	2.262
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	6.104954e-03	2.214
Regulation of PTEN gene transcription	R-HSA-8943724	6.289398e-03	2.201
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	6.405632e-03	2.193
Peptide chain elongation	R-HSA-156902	6.131490e-03	2.212
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	6.104954e-03	2.214
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	6.289398e-03	2.201
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	6.475128e-03	2.189
Regulation of endogenous retroelements	R-HSA-9842860	6.618730e-03	2.179
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	6.767226e-03	2.170
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	6.767226e-03	2.170
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	6.767226e-03	2.170
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	6.767226e-03	2.170
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	6.767226e-03	2.170
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	6.767226e-03	2.170
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	6.767226e-03	2.170
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	6.767226e-03	2.170
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	6.767226e-03	2.170
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	6.767226e-03	2.170
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	6.767226e-03	2.170
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	6.908163e-03	2.161
Chaperone Mediated Autophagy	R-HSA-9613829	6.922974e-03	2.160
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	6.922974e-03	2.160
Eukaryotic Translation Termination	R-HSA-72764	7.039730e-03	2.152
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	7.423317e-03	2.129
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	7.878038e-03	2.104
tRNA processing in the nucleus	R-HSA-6784531	7.974837e-03	2.098
SARS-CoV Infections	R-HSA-9679506	8.060542e-03	2.094
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	8.442571e-03	2.074
Folding of actin by CCT/TriC	R-HSA-390450	8.442571e-03	2.074
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	1.016001e-02	1.993
HCMV Early Events	R-HSA-9609690	9.362539e-03	2.029
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	1.013350e-02	1.994
Cell-extracellular matrix interactions	R-HSA-446353	1.016001e-02	1.993
TBC/RABGAPs	R-HSA-8854214	1.050211e-02	1.979
HIV Life Cycle	R-HSA-162587	1.051374e-02	1.978
Transcriptional regulation by small RNAs	R-HSA-5578749	1.066561e-02	1.972
Viral Infection Pathways	R-HSA-9824446	1.220753e-02	1.913
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	1.233454e-02	1.909
Diseases of programmed cell death	R-HSA-9645723	1.266482e-02	1.897
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	1.319433e-02	1.880
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	1.335214e-02	1.874
G2/M Transition	R-HSA-69275	1.424063e-02	1.846
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	1.442816e-02	1.841
Ribosome-associated quality control	R-HSA-9948299	1.458970e-02	1.836
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	1.484069e-02	1.829
Meiotic synapsis	R-HSA-1221632	1.498662e-02	1.824
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	1.552211e-02	1.809
Mitotic G2-G2/M phases	R-HSA-453274	1.601173e-02	1.796
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	1.676844e-02	1.776
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	1.733567e-02	1.761
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	1.760478e-02	1.754
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	1.780545e-02	1.749
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.780545e-02	1.749
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	2.138373e-02	1.670
Formation of annular gap junctions	R-HSA-196025	2.138373e-02	1.670
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.946964e-02	1.711
HDACs deacetylate histones	R-HSA-3214815	1.870523e-02	1.728
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.970289e-02	1.705
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.970289e-02	1.705
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	1.854902e-02	1.732
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	1.989772e-02	1.701
Late Phase of HIV Life Cycle	R-HSA-162599	2.031834e-02	1.692
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	2.090080e-02	1.680
Signaling by ALK in cancer	R-HSA-9700206	2.090080e-02	1.680
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	1.848048e-02	1.733
Developmental Lineages of the Mammary Gland	R-HSA-9924644	2.237329e-02	1.650
Selenocysteine synthesis	R-HSA-2408557	2.275301e-02	1.643
Depolymerization of the Nuclear Lamina	R-HSA-4419969	2.346357e-02	1.630
Interleukin-6 signaling	R-HSA-1059683	2.387043e-02	1.622
Death Receptor Signaling	R-HSA-73887	2.523569e-02	1.598
TRAF6 mediated NF-kB activation	R-HSA-933542	2.560274e-02	1.592
rRNA processing in the nucleus and cytosol	R-HSA-8868773	2.590173e-02	1.587
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	2.629734e-02	1.580
AURKA Activation by TPX2	R-HSA-8854518	2.630718e-02	1.580
Viral mRNA Translation	R-HSA-192823	2.641568e-02	1.578
Gap junction degradation	R-HSA-190873	2.817118e-02	1.550
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	2.947355e-02	1.531
Regulation of CDH1 Expression and Function	R-HSA-9764265	2.949801e-02	1.530
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	2.949801e-02	1.530
IRS activation	R-HSA-74713	2.950783e-02	1.530
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.950783e-02	1.530
Cell-Cell communication	R-HSA-1500931	3.087872e-02	1.510
Cellular response to starvation	R-HSA-9711097	3.178623e-02	1.498
SARS-CoV-1 Infection	R-HSA-9678108	3.284092e-02	1.484
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	3.316925e-02	1.479
Manipulation of host energy metabolism	R-HSA-9636667	3.325763e-02	1.478
Breakdown of the nuclear lamina	R-HSA-352238	3.325763e-02	1.478
mRNA Splicing - Major Pathway	R-HSA-72163	3.530170e-02	1.452
Sema3A PAK dependent Axon repulsion	R-HSA-399954	3.584191e-02	1.446
MET activates RAP1 and RAC1	R-HSA-8875555	3.610297e-02	1.442
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	3.610297e-02	1.442
Josephin domain DUBs	R-HSA-5689877	3.610297e-02	1.442
Organelle biogenesis and maintenance	R-HSA-1852241	3.616989e-02	1.442
Negative feedback regulation of MAPK pathway	R-HSA-5674499	4.114962e-02	1.386
IkBA variant leads to EDA-ID	R-HSA-5603029	4.114962e-02	1.386
Interaction between L1 and Ankyrins	R-HSA-445095	3.947350e-02	1.404
DNA Damage Recognition in GG-NER	R-HSA-5696394	3.868626e-02	1.412
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	4.000993e-02	1.398
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	4.007133e-02	1.397
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	3.947350e-02	1.404
Cilium Assembly	R-HSA-5617833	4.480512e-02	1.349
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	3.947350e-02	1.404
Muscle contraction	R-HSA-397014	3.745179e-02	1.427
Cell junction organization	R-HSA-446728	4.209367e-02	1.376
XBP1(S) activates chaperone genes	R-HSA-381038	3.994365e-02	1.399
MHC class II antigen presentation	R-HSA-2132295	4.016387e-02	1.396
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	4.520216e-02	1.345
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	4.520216e-02	1.345
Signaling by PDGFR in disease	R-HSA-9671555	4.520216e-02	1.345
Negative regulation of MAPK pathway	R-HSA-5675221	4.608282e-02	1.336
Rab regulation of trafficking	R-HSA-9007101	4.693198e-02	1.329
DNA Damage Bypass	R-HSA-73893	4.749942e-02	1.323
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	4.779703e-02	1.321
Regulation of CDH1 Function	R-HSA-9764561	4.812106e-02	1.318
TRAF3-dependent IRF activation pathway	R-HSA-918233	5.094815e-02	1.293
Disorders of Developmental Biology	R-HSA-9675151	5.094815e-02	1.293
Inositol phosphate metabolism	R-HSA-1483249	5.164530e-02	1.287
mTORC1-mediated signalling	R-HSA-166208	5.210431e-02	1.283
PRC2 methylates histones and DNA	R-HSA-212300	5.447202e-02	1.264
Regulation of NFE2L2 gene expression	R-HSA-9818749	5.475673e-02	1.262
Signaling by TGF-beta Receptor Complex	R-HSA-170834	5.520471e-02	1.258
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	5.544822e-02	1.256
Centrosome maturation	R-HSA-380287	5.568707e-02	1.254
Protein ubiquitination	R-HSA-8852135	5.568707e-02	1.254
DNA Repair	R-HSA-73894	5.602205e-02	1.252
Signaling by TGFB family members	R-HSA-9006936	5.615669e-02	1.251
Epigenetic regulation of gene expression	R-HSA-212165	5.692824e-02	1.245
mRNA Splicing	R-HSA-72172	5.891349e-02	1.230
MAPK1/MAPK3 signaling	R-HSA-5684996	5.892317e-02	1.230
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	5.970407e-02	1.224
IRE1alpha activates chaperones	R-HSA-381070	6.081421e-02	1.216
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	6.114525e-02	1.214
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	6.196983e-02	1.208
Neutrophil degranulation	R-HSA-6798695	6.197722e-02	1.208
mRNA 3'-end processing	R-HSA-72187	6.234791e-02	1.205
Protein-protein interactions at synapses	R-HSA-6794362	6.268202e-02	1.203
HATs acetylate histones	R-HSA-3214847	6.268999e-02	1.203
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	7.022436e-02	1.154
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	6.684512e-02	1.175
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	7.935644e-02	1.100
Impaired BRCA2 binding to PALB2	R-HSA-9709603	7.961228e-02	1.099
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	6.773498e-02	1.169
Long-term potentiation	R-HSA-9620244	7.646618e-02	1.117
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	6.789498e-02	1.168
Nuclear Receptor transcription pathway	R-HSA-383280	6.910172e-02	1.161
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	6.684512e-02	1.175
Platelet sensitization by LDL	R-HSA-432142	6.926171e-02	1.160
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	7.912963e-02	1.102
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	6.684512e-02	1.175
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	7.646618e-02	1.117
RAF/MAP kinase cascade	R-HSA-5673001	6.407200e-02	1.193
CD209 (DC-SIGN) signaling	R-HSA-5621575	6.773498e-02	1.169
Disorders of Nervous System Development	R-HSA-9697154	6.684512e-02	1.175
Pervasive developmental disorders	R-HSA-9005895	6.684512e-02	1.175
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	6.684512e-02	1.175
Neurodegenerative Diseases	R-HSA-8863678	6.773498e-02	1.169
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	6.773498e-02	1.169
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	7.097429e-02	1.149
HIV Infection	R-HSA-162906	7.154299e-02	1.145
PI Metabolism	R-HSA-1483255	7.516219e-02	1.124
Smooth Muscle Contraction	R-HSA-445355	6.789498e-02	1.168
Reproduction	R-HSA-1474165	6.702204e-02	1.174
Viral Messenger RNA Synthesis	R-HSA-168325	6.715014e-02	1.173
Transcriptional Regulation by TP53	R-HSA-3700989	7.769454e-02	1.110
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	7.935644e-02	1.100
Unfolded Protein Response (UPR)	R-HSA-381119	7.102955e-02	1.149
Gene Silencing by RNA	R-HSA-211000	6.419870e-02	1.192
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	7.992657e-02	1.097
Homology Directed Repair	R-HSA-5693538	8.144971e-02	1.089
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	8.179942e-02	1.087
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	8.179942e-02	1.087
Processing of DNA double-strand break ends	R-HSA-5693607	8.447465e-02	1.073
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	8.700091e-02	1.060
Type I hemidesmosome assembly	R-HSA-446107	8.741976e-02	1.058
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	8.741976e-02	1.058
Intraflagellar transport	R-HSA-5620924	8.800695e-02	1.055
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	8.837937e-02	1.054
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	8.883888e-02	1.051
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	9.007698e-02	1.045
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	9.007698e-02	1.045
Clathrin-mediated endocytosis	R-HSA-8856828	9.041159e-02	1.044
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	9.074059e-02	1.042
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	9.074059e-02	1.042
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	9.074059e-02	1.042
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	9.074059e-02	1.042
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	9.074059e-02	1.042
Nephrin family interactions	R-HSA-373753	9.074059e-02	1.042
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	9.190812e-02	1.037
G2/M DNA damage checkpoint	R-HSA-69473	9.354431e-02	1.029
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	9.418327e-02	1.026
DNA Double-Strand Break Repair	R-HSA-5693532	9.421737e-02	1.026
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	9.476356e-02	1.023
Dual Incision in GG-NER	R-HSA-5696400	9.731731e-02	1.012
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	1.018443e-01	0.992
p75 NTR receptor-mediated signalling	R-HSA-193704	1.042024e-01	0.982
MTOR signalling	R-HSA-165159	1.054435e-01	0.977
RNA Polymerase I Transcription Initiation	R-HSA-73762	1.054435e-01	0.977
Regulation of gap junction activity	R-HSA-191650	1.109254e-01	0.955
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	1.109254e-01	0.955
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	1.061909e-01	0.974
ALK mutants bind TKIs	R-HSA-9700645	1.061909e-01	0.974
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	1.263734e-01	0.898
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	1.075451e-01	0.968
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.075451e-01	0.968
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	1.231098e-01	0.910
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	1.395672e-01	0.855
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	1.152406e-01	0.938
Termination of translesion DNA synthesis	R-HSA-5656169	1.173500e-01	0.931
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	1.173500e-01	0.931
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	1.289943e-01	0.889
G1/S-Specific Transcription	R-HSA-69205	1.166195e-01	0.933
RNA Polymerase II Transcription Termination	R-HSA-73856	1.232797e-01	0.909
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	1.395672e-01	0.855
MAPK6/MAPK4 signaling	R-HSA-5687128	1.080792e-01	0.966
Regulation of IFNA/IFNB signaling	R-HSA-912694	1.285545e-01	0.891
Deadenylation-dependent mRNA decay	R-HSA-429914	1.076059e-01	0.968
Prolonged ERK activation events	R-HSA-169893	1.231098e-01	0.910
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	1.348374e-01	0.870
RNA Polymerase I Transcription	R-HSA-73864	1.200289e-01	0.921
NoRC negatively regulates rRNA expression	R-HSA-427413	1.335681e-01	0.874
RNA Polymerase I Promoter Clearance	R-HSA-73854	1.062994e-01	0.973
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	1.395672e-01	0.855
Neurexins and neuroligins	R-HSA-6794361	1.196376e-01	0.922
rRNA processing	R-HSA-72312	1.208927e-01	0.918
MyD88-independent TLR4 cascade	R-HSA-166166	1.218681e-01	0.914
Evasion by RSV of host interferon responses	R-HSA-9833109	1.411704e-01	0.850
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	1.218681e-01	0.914
TCF dependent signaling in response to WNT	R-HSA-201681	1.083456e-01	0.965
Signal attenuation	R-HSA-74749	1.263734e-01	0.898
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.067337e-01	0.972
Deubiquitination	R-HSA-5688426	1.372414e-01	0.863
S Phase	R-HSA-69242	1.129490e-01	0.947
Notch-HLH transcription pathway	R-HSA-350054	1.285545e-01	0.891
Budding and maturation of HIV virion	R-HSA-162588	1.411704e-01	0.850
Ovarian tumor domain proteases	R-HSA-5689896	1.269637e-01	0.896
Heme signaling	R-HSA-9707616	1.315611e-01	0.881
HCMV Late Events	R-HSA-9610379	1.119122e-01	0.951
Platelet degranulation	R-HSA-114608	1.321156e-01	0.879
G2/M Checkpoints	R-HSA-69481	1.321156e-01	0.879
Regulated proteolysis of p75NTR	R-HSA-193692	1.061909e-01	0.974
Regulation of TP53 Activity	R-HSA-5633007	1.264535e-01	0.898
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	1.075451e-01	0.968
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	1.395672e-01	0.855
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	1.285545e-01	0.891
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.269637e-01	0.896
Host Interactions of HIV factors	R-HSA-162909	1.100301e-01	0.958
Transport to the Golgi and subsequent modification	R-HSA-948021	1.097493e-01	0.960
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	1.109254e-01	0.955
Defective pyroptosis	R-HSA-9710421	1.143465e-01	0.942
p75NTR signals via NF-kB	R-HSA-193639	1.075451e-01	0.968
CASP4 inflammasome assembly	R-HSA-9948001	1.263734e-01	0.898
Signaling by Interleukins	R-HSA-449147	1.334866e-01	0.875
Sensory processing of sound	R-HSA-9659379	1.272545e-01	0.895
Interleukin-1 processing	R-HSA-448706	1.061909e-01	0.974
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	1.422563e-01	0.847
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	1.422563e-01	0.847
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	1.425318e-01	0.846
Adherens junctions interactions	R-HSA-418990	1.429015e-01	0.845
Condensation of Prophase Chromosomes	R-HSA-2299718	1.433708e-01	0.844
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	1.477966e-01	0.830
Signaling by APC mutants	R-HSA-4839744	1.477966e-01	0.830
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.477966e-01	0.830
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.477966e-01	0.830
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.477966e-01	0.830
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	1.482910e-01	0.829
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	1.489731e-01	0.827
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.720450e-01	0.764
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	1.720450e-01	0.764
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.720450e-01	0.764
Diseases of Telomere Maintenance	R-HSA-9673013	1.720450e-01	0.764
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.720450e-01	0.764
Impaired BRCA2 binding to SEM1 (DSS1)	R-HSA-9763198	1.720450e-01	0.764
TICAM1 deficiency - HSE	R-HSA-5602566	1.720450e-01	0.764
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function	R-HSA-9645722	1.720450e-01	0.764
Impaired BRCA2 translocation to the nucleus	R-HSA-9709275	1.720450e-01	0.764
Hereditary fructose intolerance	R-HSA-5657560	1.720450e-01	0.764
RPIA deficiency: failed conversion of R5P to RU5P	R-HSA-5659996	1.720450e-01	0.764
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	1.720450e-01	0.764
RPIA deficiency: failed conversion of RU5P to R5P	R-HSA-6791461	1.720450e-01	0.764
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.720450e-01	0.764
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	2.466335e-01	0.608
Defective SLC26A2 causes chondrodysplasias	R-HSA-3560792	2.466335e-01	0.608
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	2.466335e-01	0.608
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	2.466335e-01	0.608
Defective GFPT1 causes CMSTA1	R-HSA-4085023	2.466335e-01	0.608
TRAF3 deficiency - HSE	R-HSA-5602571	2.466335e-01	0.608
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.466335e-01	0.608
PTEN Loss of Function in Cancer	R-HSA-5674404	2.466335e-01	0.608
Signaling by TCF7L2 mutants	R-HSA-5339700	2.466335e-01	0.608
Pentose phosphate pathway disease	R-HSA-6791465	1.751590e-01	0.757
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	3.145065e-01	0.502
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	3.145065e-01	0.502
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.145065e-01	0.502
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.145065e-01	0.502
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	1.702878e-01	0.769
Signaling by GSK3beta mutants	R-HSA-5339716	1.702878e-01	0.769
TRIF-mediated programmed cell death	R-HSA-2562578	2.436164e-01	0.613
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	2.436164e-01	0.613
Recycling of eIF2:GDP	R-HSA-72731	2.436164e-01	0.613
SOS-mediated signalling	R-HSA-112412	2.436164e-01	0.613
FasL/ CD95L signaling	R-HSA-75157	3.762683e-01	0.425
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	3.762683e-01	0.425
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	3.762683e-01	0.425
MET activates PTPN11	R-HSA-8865999	3.762683e-01	0.425
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.936761e-01	0.713
Polymerase switching	R-HSA-69091	1.936761e-01	0.713
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	1.936761e-01	0.713
Leading Strand Synthesis	R-HSA-69109	1.936761e-01	0.713
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	1.936761e-01	0.713
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	1.936761e-01	0.713
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	1.936761e-01	0.713
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	1.936761e-01	0.713
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	1.568444e-01	0.805
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	2.177950e-01	0.662
Signaling by ERBB2 ECD mutants	R-HSA-9665348	1.748649e-01	0.757
Deadenylation of mRNA	R-HSA-429947	1.571332e-01	0.804
ARMS-mediated activation	R-HSA-170984	3.129456e-01	0.505
Lipophagy	R-HSA-9613354	3.129456e-01	0.505
WNT mediated activation of DVL	R-HSA-201688	3.129456e-01	0.505
MAPK1 (ERK2) activation	R-HSA-112411	3.129456e-01	0.505
Hypusine synthesis from eIF5A-lysine	R-HSA-204626	3.129456e-01	0.505
CASP8 activity is inhibited	R-HSA-5218900	3.129456e-01	0.505
AKT-mediated inactivation of FOXO1A	R-HSA-211163	4.324688e-01	0.364
PLCG1 events in ERBB2 signaling	R-HSA-1251932	4.324688e-01	0.364
Inhibition of TSC complex formation by PKB	R-HSA-165181	4.324688e-01	0.364
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	4.324688e-01	0.364
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	4.324688e-01	0.364
Signaling by MAP2K mutants	R-HSA-9652169	4.324688e-01	0.364
GRB7 events in ERBB2 signaling	R-HSA-1306955	4.324688e-01	0.364
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	4.324688e-01	0.364
SWI/SNF chromatin remodelers	R-HSA-9932451	1.723167e-01	0.764
ATP-dependent chromatin remodelers	R-HSA-9932444	1.723167e-01	0.764
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	1.723167e-01	0.764
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	2.128168e-01	0.672
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	2.128168e-01	0.672
Diseases of mitotic cell cycle	R-HSA-9675126	1.538549e-01	0.813
Beta-catenin phosphorylation cascade	R-HSA-196299	2.675941e-01	0.573
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	1.670220e-01	0.777
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	2.325866e-01	0.633
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	3.471778e-01	0.459
2-LTR circle formation	R-HSA-164843	3.471778e-01	0.459
Cristae formation	R-HSA-8949613	2.042491e-01	0.690
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	2.929809e-01	0.533
Class I peroxisomal membrane protein import	R-HSA-9603798	2.929809e-01	0.533
Phosphorylation of the APC/C	R-HSA-176412	2.929809e-01	0.533
DNA methylation	R-HSA-5334118	2.379518e-01	0.624
Impaired BRCA2 binding to RAD51	R-HSA-9709570	2.379518e-01	0.624
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	2.733125e-01	0.563
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	3.185132e-01	0.497
RHOBTB3 ATPase cycle	R-HSA-9706019	3.808217e-01	0.419
Activation of the pre-replicative complex	R-HSA-68962	2.553446e-01	0.593
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	2.553446e-01	0.593
SIRT1 negatively regulates rRNA expression	R-HSA-427359	2.390713e-01	0.621
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	3.440697e-01	0.463
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	4.137055e-01	0.383
Nucleosome assembly	R-HSA-774815	2.379845e-01	0.623
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	2.379845e-01	0.623
FOXO-mediated transcription of cell death genes	R-HSA-9614657	3.695396e-01	0.432
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	3.695396e-01	0.432
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	3.948228e-01	0.404
IKK complex recruitment mediated by RIP1	R-HSA-937041	3.948228e-01	0.404
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	4.456931e-01	0.351
Scavenging by Class F Receptors	R-HSA-3000484	4.456931e-01	0.351
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	3.457680e-01	0.461
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	3.785289e-01	0.422
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	3.348976e-01	0.475
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	4.198298e-01	0.377
Formation of ATP by chemiosmotic coupling	R-HSA-163210	4.198298e-01	0.377
Formation of RNA Pol II elongation complex	R-HSA-112382	3.397283e-01	0.469
TNFR1-induced proapoptotic signaling	R-HSA-5357786	4.444811e-01	0.352
RNA Polymerase II Transcription Elongation	R-HSA-75955	3.548065e-01	0.450
Signaling by Erythropoietin	R-HSA-9006335	4.205591e-01	0.376
Signaling by ERBB2 KD Mutants	R-HSA-9664565	4.205591e-01	0.376
Signaling by ERBB2 in Cancer	R-HSA-1227990	4.413303e-01	0.355
Inhibition of DNA recombination at telomere	R-HSA-9670095	4.559131e-01	0.341
Dual incision in TC-NER	R-HSA-6782135	4.306459e-01	0.366
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	3.184982e-01	0.497
Chromosome Maintenance	R-HSA-73886	2.983805e-01	0.525
Interferon alpha/beta signaling	R-HSA-909733	3.368830e-01	0.473
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	3.457680e-01	0.461
Lagging Strand Synthesis	R-HSA-69186	4.444811e-01	0.352
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	1.726358e-01	0.763
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	3.573777e-01	0.447
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	1.702878e-01	0.769
Nucleotide Excision Repair	R-HSA-5696398	2.221233e-01	0.653
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	2.553446e-01	0.593
Integration of provirus	R-HSA-162592	4.137055e-01	0.383
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	1.875894e-01	0.727
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	2.083475e-01	0.681
TRAF6 mediated IRF7 activation	R-HSA-933541	4.011177e-01	0.397
DNA Double Strand Break Response	R-HSA-5693606	2.810375e-01	0.551
RET signaling	R-HSA-8853659	3.826781e-01	0.417
RIPK1-mediated regulated necrosis	R-HSA-5213460	2.545010e-01	0.594
HDMs demethylate histones	R-HSA-3214842	3.362146e-01	0.473
Activation of PUMA and translocation to mitochondria	R-HSA-139915	2.436164e-01	0.613
PI3K/AKT activation	R-HSA-198203	3.471778e-01	0.459
Formation of Incision Complex in GG-NER	R-HSA-5696395	1.606067e-01	0.794
Regulation of localization of FOXO transcription factors	R-HSA-9614399	3.808217e-01	0.419
Synthesis of PIPs at the ER membrane	R-HSA-1483248	3.808217e-01	0.419
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	3.440697e-01	0.463
DNA strand elongation	R-HSA-69190	2.909668e-01	0.536
VEGFR2 mediated vascular permeability	R-HSA-5218920	3.022252e-01	0.520
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	1.994654e-01	0.700
Downregulation of ERBB2 signaling	R-HSA-8863795	2.553446e-01	0.593
PTEN Regulation	R-HSA-6807070	3.091655e-01	0.510
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	2.929809e-01	0.533
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	3.457680e-01	0.461
Regulation of necroptotic cell death	R-HSA-5675482	1.670220e-01	0.777
Sodium/Proton exchangers	R-HSA-425986	2.783381e-01	0.555
Regulation by c-FLIP	R-HSA-3371378	2.783381e-01	0.555
Microbial factors inhibit CASP4 activity	R-HSA-9956593	2.177950e-01	0.662
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	3.185132e-01	0.497
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	2.239375e-01	0.650
E2F mediated regulation of DNA replication	R-HSA-113510	3.948228e-01	0.404
Regulation of IFNG signaling	R-HSA-877312	4.456931e-01	0.351
DNA Replication Pre-Initiation	R-HSA-69002	3.579368e-01	0.446
Ca-dependent events	R-HSA-111996	3.348976e-01	0.475
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	4.295081e-01	0.367
Nuclear events mediated by NFE2L2	R-HSA-9759194	2.983805e-01	0.525
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	2.042491e-01	0.690
Repression of WNT target genes	R-HSA-4641265	4.456931e-01	0.351
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	3.642146e-01	0.439
CaM pathway	R-HSA-111997	3.826781e-01	0.417
HDR through Homologous Recombination (HRR)	R-HSA-5685942	4.131465e-01	0.384
RNA Polymerase II Pre-transcription Events	R-HSA-674695	2.513205e-01	0.600
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	3.471778e-01	0.459
Meiotic recombination	R-HSA-912446	1.987999e-01	0.702
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	4.194942e-01	0.377
Calmodulin induced events	R-HSA-111933	3.826781e-01	0.417
Resolution of D-Loop Structures	R-HSA-5693537	3.273812e-01	0.485
Activation and oligomerization of BAK protein	R-HSA-111452	1.720450e-01	0.764
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	2.436164e-01	0.613
Dimerization of procaspase-8	R-HSA-69416	2.783381e-01	0.555
Calcineurin activates NFAT	R-HSA-2025928	3.129456e-01	0.505
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	4.137055e-01	0.383
Polymerase switching on the C-strand of the telomere	R-HSA-174411	3.362146e-01	0.473
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	3.090988e-01	0.510
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	3.152106e-01	0.501
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	3.152106e-01	0.501
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	3.152106e-01	0.501
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	3.152106e-01	0.501
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	4.505886e-01	0.346
Regulation of TNFR1 signaling	R-HSA-5357905	2.519349e-01	0.599
Assembly of the pre-replicative complex	R-HSA-68867	2.716778e-01	0.566
Translation	R-HSA-72766	2.607396e-01	0.584
Ephrin signaling	R-HSA-3928664	3.695396e-01	0.432
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	4.272282e-01	0.369
Oncogene Induced Senescence	R-HSA-2559585	2.091332e-01	0.680
Circadian clock	R-HSA-9909396	2.406872e-01	0.619
Synaptic adhesion-like molecules	R-HSA-8849932	3.695396e-01	0.432
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	4.456931e-01	0.351
TNF signaling	R-HSA-75893	1.566278e-01	0.805
Interleukin-6 family signaling	R-HSA-6783589	1.571332e-01	0.804
Frs2-mediated activation	R-HSA-170968	2.177950e-01	0.662
Interleukin-35 Signalling	R-HSA-8984722	4.456931e-01	0.351
Signaling by FLT3 fusion proteins	R-HSA-9703465	3.573777e-01	0.447
Aryl hydrocarbon receptor signalling	R-HSA-8937144	1.751590e-01	0.757
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	2.424848e-01	0.615
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	4.324688e-01	0.364
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	1.880375e-01	0.726
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	1.537848e-01	0.813
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	2.733125e-01	0.563
Chylomicron assembly	R-HSA-8963888	3.808217e-01	0.419
Polo-like kinase mediated events	R-HSA-156711	3.695396e-01	0.432
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	2.298209e-01	0.639
Signaling by WNT	R-HSA-195721	3.818405e-01	0.418
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	1.604264e-01	0.795
MET promotes cell motility	R-HSA-8875878	2.545010e-01	0.594
KEAP1-NFE2L2 pathway	R-HSA-9755511	3.356927e-01	0.474
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	3.573777e-01	0.447
Adipogenesis	R-HSA-9843745	2.325884e-01	0.633
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	2.128168e-01	0.672
Myogenesis	R-HSA-525793	1.880375e-01	0.726
Rap1 signalling	R-HSA-392517	3.948228e-01	0.404
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	2.805215e-01	0.552
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	3.573777e-01	0.447
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	3.462333e-01	0.461
Maternal to zygotic transition (MZT)	R-HSA-9816359	3.174550e-01	0.498
EPH-Ephrin signaling	R-HSA-2682334	3.703834e-01	0.431
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	2.209807e-01	0.656
Formation of editosomes by ADAR proteins	R-HSA-77042	1.720450e-01	0.764
Activation, translocation and oligomerization of BAX	R-HSA-114294	1.720450e-01	0.764
Inhibition of PKR	R-HSA-169131	1.720450e-01	0.764
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	2.466335e-01	0.608
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	2.466335e-01	0.608
Transport of connexins along the secretory pathway	R-HSA-190827	2.466335e-01	0.608
Inhibition of Host mRNA Processing and RNA Silencing	R-HSA-168315	2.466335e-01	0.608
mRNA Editing: A to I Conversion	R-HSA-75064	3.145065e-01	0.502
C6 deamination of adenosine	R-HSA-75102	3.145065e-01	0.502
CREB phosphorylation	R-HSA-199920	2.090968e-01	0.680
Signaling by AMER1 mutants	R-HSA-4839748	1.702878e-01	0.769
Signaling by AXIN mutants	R-HSA-4839735	1.702878e-01	0.769
STAT6-mediated induction of chemokines	R-HSA-3249367	3.762683e-01	0.425
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	3.762683e-01	0.425
MET interacts with TNS proteins	R-HSA-8875513	3.762683e-01	0.425
Membrane binding and targetting of GAG proteins	R-HSA-174490	2.177950e-01	0.662
Physiological factors	R-HSA-5578768	2.424848e-01	0.615
Inactivation of CDC42 and RAC1	R-HSA-428543	3.129456e-01	0.505
Unwinding of DNA	R-HSA-176974	3.129456e-01	0.505
Interleukin-27 signaling	R-HSA-9020956	3.471778e-01	0.459
Platelet calcium homeostasis	R-HSA-418360	2.379518e-01	0.624
Bicarbonate transporters	R-HSA-425381	3.808217e-01	0.419
NF-kB is activated and signals survival	R-HSA-209560	4.137055e-01	0.383
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	3.695396e-01	0.432
RNA Polymerase I Promoter Opening	R-HSA-73728	3.785289e-01	0.422
Phase 0 - rapid depolarisation	R-HSA-5576892	3.996080e-01	0.398
Diseases of Immune System	R-HSA-5260271	4.559131e-01	0.341
Diseases associated with the TLR signaling cascade	R-HSA-5602358	4.559131e-01	0.341
Cellular responses to mechanical stimuli	R-HSA-9855142	3.068101e-01	0.513
Regulated Necrosis	R-HSA-5218859	1.870987e-01	0.728
Response of endothelial cells to shear stress	R-HSA-9860931	4.033808e-01	0.394
Toll-like Receptor Cascades	R-HSA-168898	3.406957e-01	0.468
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	1.880375e-01	0.726
Mismatch Repair	R-HSA-5358508	3.695396e-01	0.432
Ion transport by P-type ATPases	R-HSA-936837	3.708890e-01	0.431
Gene expression (Transcription)	R-HSA-74160	2.021869e-01	0.694
Sema4D in semaphorin signaling	R-HSA-400685	1.723167e-01	0.764
Early Phase of HIV Life Cycle	R-HSA-162594	4.444811e-01	0.352
Assembly of the ORC complex at the origin of replication	R-HSA-68616	3.090988e-01	0.510
Cellular response to chemical stress	R-HSA-9711123	3.883979e-01	0.411
Regulation of NPAS4 gene transcription	R-HSA-9768777	3.129456e-01	0.505
Estrogen-dependent gene expression	R-HSA-9018519	3.746837e-01	0.426
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	2.290855e-01	0.640
MAP kinase activation	R-HSA-450294	3.290013e-01	0.483
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	2.091332e-01	0.680
NGF-stimulated transcription	R-HSA-9031628	2.805215e-01	0.552
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	3.129456e-01	0.505
ERK/MAPK targets	R-HSA-198753	4.444811e-01	0.352
RNA Polymerase II Transcription	R-HSA-73857	4.098335e-01	0.387
Oxidative Stress Induced Senescence	R-HSA-2559580	2.749083e-01	0.561
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	4.011177e-01	0.397
Ion homeostasis	R-HSA-5578775	2.614342e-01	0.583
Signaling by NOTCH1 in Cancer	R-HSA-2644603	3.152106e-01	0.501
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	4.413303e-01	0.355
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	1.806440e-01	0.743
Nef and signal transduction	R-HSA-164944	2.090968e-01	0.680
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	2.424848e-01	0.615
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	3.129456e-01	0.505
Activation of NOXA and translocation to mitochondria	R-HSA-111448	4.324688e-01	0.364
Signaling by LTK	R-HSA-9842663	4.456931e-01	0.351
Interleukin-17 signaling	R-HSA-448424	4.552805e-01	0.342
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.813932e-01	0.551
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	3.472864e-01	0.459
TGFBR3 expression	R-HSA-9839394	1.723167e-01	0.764
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	2.042491e-01	0.690
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	2.861121e-01	0.543
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	2.861121e-01	0.543
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	1.764382e-01	0.753
Signaling by MET	R-HSA-6806834	4.502740e-01	0.347
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	4.082667e-01	0.389
Regulation of PD-L1(CD274) expression	R-HSA-9909648	4.404787e-01	0.356
Oligomerization of connexins into connexons	R-HSA-190704	2.466335e-01	0.608
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	1.751590e-01	0.757
Reduction of cytosolic Ca++ levels	R-HSA-418359	1.702878e-01	0.769
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	3.762683e-01	0.425
Signaling by Hippo	R-HSA-2028269	1.568444e-01	0.805
GP1b-IX-V activation signalling	R-HSA-430116	3.129456e-01	0.505
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	3.129456e-01	0.505
Cellular response to mitochondrial stress	R-HSA-9840373	3.129456e-01	0.505
Protein methylation	R-HSA-8876725	2.675941e-01	0.573
Activation of ATR in response to replication stress	R-HSA-176187	1.670220e-01	0.777
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	2.929809e-01	0.533
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	2.614342e-01	0.583
Signaling by NODAL	R-HSA-1181150	4.198298e-01	0.377
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	4.444811e-01	0.352
DARPP-32 events	R-HSA-180024	4.205591e-01	0.376
G alpha (12/13) signalling events	R-HSA-416482	4.239268e-01	0.373
Nuclear signaling by ERBB4	R-HSA-1251985	4.559131e-01	0.341
Cell-cell junction organization	R-HSA-421270	1.626578e-01	0.789
MyD88 cascade initiated on plasma membrane	R-HSA-975871	3.362129e-01	0.473
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	4.205591e-01	0.376
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	3.362129e-01	0.473
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	3.362129e-01	0.473
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	2.290855e-01	0.640
Transcriptional Regulation by VENTX	R-HSA-8853884	3.022252e-01	0.520
Formation of definitive endoderm	R-HSA-9823730	4.198298e-01	0.377
MyD88 dependent cascade initiated on endosome	R-HSA-975155	3.579368e-01	0.446
Potential therapeutics for SARS	R-HSA-9679191	1.768307e-01	0.752
Signaling by TGFBR3	R-HSA-9839373	2.519349e-01	0.599
Resolution of Abasic Sites (AP sites)	R-HSA-73933	3.022252e-01	0.520
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	2.347625e-01	0.629
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	3.319525e-01	0.479
Gluconeogenesis	R-HSA-70263	1.645488e-01	0.784
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	2.661224e-01	0.575
Signaling by NTRKs	R-HSA-166520	3.094830e-01	0.509
Histamine receptors	R-HSA-390650	3.762683e-01	0.425
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	2.424848e-01	0.615
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	3.471778e-01	0.459
The NLRP3 inflammasome	R-HSA-844456	1.935492e-01	0.713
Non-integrin membrane-ECM interactions	R-HSA-3000171	1.675070e-01	0.776
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	4.009746e-01	0.397
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	4.444811e-01	0.352
Diseases of DNA repair	R-HSA-9675135	4.011156e-01	0.397
CLEC7A/inflammasome pathway	R-HSA-5660668	1.751590e-01	0.757
Sodium/Calcium exchangers	R-HSA-425561	1.702878e-01	0.769
Displacement of DNA glycosylase by APEX1	R-HSA-110357	2.436164e-01	0.613
AKT phosphorylates targets in the nucleus	R-HSA-198693	3.129456e-01	0.505
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	3.471778e-01	0.459
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	2.527782e-01	0.597
Metal ion SLC transporters	R-HSA-425410	1.645488e-01	0.784
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	2.108932e-01	0.676
Activation of RAC1	R-HSA-428540	4.137055e-01	0.383
Negative regulation of MET activity	R-HSA-6807004	4.198298e-01	0.377
Mitochondrial biogenesis	R-HSA-1592230	2.613542e-01	0.583
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.954555e-01	0.709
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	4.334653e-01	0.363
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	3.397283e-01	0.469
Zinc transporters	R-HSA-435354	2.424848e-01	0.615
p75NTR recruits signalling complexes	R-HSA-209543	4.456931e-01	0.351
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	3.843135e-01	0.415
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	3.339840e-01	0.476
Growth hormone receptor signaling	R-HSA-982772	2.941124e-01	0.531
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	2.746307e-01	0.561
MITF-M-regulated melanocyte development	R-HSA-9730414	4.430614e-01	0.354
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	2.436164e-01	0.613
Uptake and function of diphtheria toxin	R-HSA-5336415	2.436164e-01	0.613
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	2.783381e-01	0.555
Respiratory syncytial virus genome replication	R-HSA-9834752	3.129456e-01	0.505
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	3.808217e-01	0.419
Inflammasomes	R-HSA-622312	3.996080e-01	0.398
MITF-M-dependent gene expression	R-HSA-9856651	4.198682e-01	0.377
Triglyceride catabolism	R-HSA-163560	3.826781e-01	0.417
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	3.185132e-01	0.497
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	2.941124e-01	0.531
NRAGE signals death through JNK	R-HSA-193648	2.614342e-01	0.583
Signaling by ALK	R-HSA-201556	4.377709e-01	0.359
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	3.129456e-01	0.505
Butyrophilin (BTN) family interactions	R-HSA-8851680	3.129456e-01	0.505
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	1.566278e-01	0.805
Selenoamino acid metabolism	R-HSA-2408522	2.059750e-01	0.686
Non-canonical inflammasome activation	R-HSA-9686114	2.424848e-01	0.615
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	3.580161e-01	0.446
Interleukin-7 signaling	R-HSA-1266695	3.362146e-01	0.473
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	4.444811e-01	0.352
Signaling by Leptin	R-HSA-2586552	3.471778e-01	0.459
Pyroptosis	R-HSA-5620971	3.996080e-01	0.398
Maturation of hRSV A proteins	R-HSA-9828806	3.785289e-01	0.422
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	1.748649e-01	0.757
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	2.733125e-01	0.563
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	4.575130e-01	0.340
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	4.575844e-01	0.340
Signaling by ERBB2	R-HSA-1227986	4.607720e-01	0.337
Sphingolipid de novo biosynthesis	R-HSA-1660661	4.607720e-01	0.337
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	4.687068e-01	0.329
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	4.687068e-01	0.329
Assembly Of The HIV Virion	R-HSA-175474	4.687068e-01	0.329
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	4.738884e-01	0.324
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	4.766793e-01	0.322
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	4.766793e-01	0.322
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	4.766793e-01	0.322
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	4.766793e-01	0.322
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	4.766793e-01	0.322
CD28 dependent Vav1 pathway	R-HSA-389359	4.766793e-01	0.322
G0 and Early G1	R-HSA-1538133	4.821471e-01	0.317
Signaling by WNT in cancer	R-HSA-4791275	4.821471e-01	0.317
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	4.821471e-01	0.317
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	4.821471e-01	0.317
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	4.836085e-01	0.316
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	4.836085e-01	0.316
PTK6 Down-Regulation	R-HSA-8849472	4.836085e-01	0.316
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	4.836085e-01	0.316
Activation of C3 and C5	R-HSA-174577	4.836085e-01	0.316
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	4.836085e-01	0.316
Muscarinic acetylcholine receptors	R-HSA-390648	4.836085e-01	0.316
Inositol transporters	R-HSA-429593	4.836085e-01	0.316
Zinc efflux and compartmentalization by the SLC30 family	R-HSA-435368	4.836085e-01	0.316
Assembly of Viral Components at the Budding Site	R-HSA-168316	4.836085e-01	0.316
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	4.883396e-01	0.311
Cytoprotection by HMOX1	R-HSA-9707564	4.894241e-01	0.310
Transcriptional regulation of granulopoiesis	R-HSA-9616222	4.905324e-01	0.309
FGFR2 alternative splicing	R-HSA-6803529	4.924465e-01	0.308
RAF-independent MAPK1/3 activation	R-HSA-112409	4.924465e-01	0.308
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	4.924465e-01	0.308
Switching of origins to a post-replicative state	R-HSA-69052	4.968391e-01	0.304
RNA Polymerase I Promoter Escape	R-HSA-73772	4.990936e-01	0.302
Integrin signaling	R-HSA-354192	5.021102e-01	0.299
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	5.021102e-01	0.299
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	5.021102e-01	0.299
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	5.021102e-01	0.299
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	5.023236e-01	0.299
rRNA modification in the nucleus and cytosol	R-HSA-6790901	5.052298e-01	0.297
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	5.065847e-01	0.295
Removal of the Flap Intermediate	R-HSA-69166	5.065847e-01	0.295
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	5.065847e-01	0.295
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	5.065847e-01	0.295
CRMPs in Sema3A signaling	R-HSA-399956	5.065847e-01	0.295
Golgi Associated Vesicle Biogenesis	R-HSA-432722	5.149388e-01	0.288
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	5.156482e-01	0.288
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	5.197830e-01	0.284
Heme degradation	R-HSA-189483	5.217281e-01	0.283
Miscellaneous transport and binding events	R-HSA-5223345	5.217281e-01	0.283
Opioid Signalling	R-HSA-111885	5.230770e-01	0.281
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	5.240250e-01	0.281
Immune System	R-HSA-168256	5.277986e-01	0.278
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	5.278257e-01	0.278
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	5.301428e-01	0.276
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	5.301428e-01	0.276
Loss-of-function mutations in DBT cause MSUD2	R-HSA-9865113	5.301428e-01	0.276
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	5.301428e-01	0.276
Loss-of-function mutations in DLD cause MSUD3/DLDD	R-HSA-9907570	5.301428e-01	0.276
Noncanonical activation of NOTCH3	R-HSA-9017802	5.301428e-01	0.276
Cam-PDE 1 activation	R-HSA-111957	5.301428e-01	0.276
CDC6 association with the ORC:origin complex	R-HSA-68689	5.301428e-01	0.276
Signalling to p38 via RIT and RIN	R-HSA-187706	5.301428e-01	0.276
Orexin and neuropeptides FF and QRFP bind to their respective receptors	R-HSA-389397	5.301428e-01	0.276
Regulation of CDH19 Expression and Function	R-HSA-9764302	5.301428e-01	0.276
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	5.301428e-01	0.276
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	5.301428e-01	0.276
RSV-host interactions	R-HSA-9833110	5.344823e-01	0.272
Erythropoietin activates RAS	R-HSA-9027284	5.353526e-01	0.271
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	5.353526e-01	0.271
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	5.353526e-01	0.271
Processive synthesis on the lagging strand	R-HSA-69183	5.353526e-01	0.271
IRF3-mediated induction of type I IFN	R-HSA-3270619	5.353526e-01	0.271
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	5.353526e-01	0.271
Biotin transport and metabolism	R-HSA-196780	5.353526e-01	0.271
Other semaphorin interactions	R-HSA-416700	5.353526e-01	0.271
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	5.353526e-01	0.271
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	5.353526e-01	0.271
DCC mediated attractive signaling	R-HSA-418885	5.353526e-01	0.271
Signaling by NOTCH1	R-HSA-1980143	5.374215e-01	0.270
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	5.382682e-01	0.269
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	5.409698e-01	0.267
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	5.409698e-01	0.267
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	5.409698e-01	0.267
RMTs methylate histone arginines	R-HSA-3214858	5.435522e-01	0.265
Signaling by NOTCH3	R-HSA-9012852	5.460252e-01	0.263
DNA Replication	R-HSA-69306	5.477889e-01	0.261
Transmission across Chemical Synapses	R-HSA-112315	5.508568e-01	0.259
CLEC7A (Dectin-1) signaling	R-HSA-5607764	5.549690e-01	0.256
Platelet homeostasis	R-HSA-418346	5.570067e-01	0.254
Signalling to ERKs	R-HSA-187687	5.598078e-01	0.252
Tight junction interactions	R-HSA-420029	5.602703e-01	0.252
Glycogen breakdown (glycogenolysis)	R-HSA-70221	5.602703e-01	0.252
DAG and IP3 signaling	R-HSA-1489509	5.602869e-01	0.252
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	5.602869e-01	0.252
G1/S Transition	R-HSA-69206	5.608907e-01	0.251
Signaling by EGFR	R-HSA-177929	5.612315e-01	0.251
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	5.629451e-01	0.250
Killing mechanisms	R-HSA-9664420	5.629451e-01	0.250
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	5.629451e-01	0.250
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	5.629451e-01	0.250
Mineralocorticoid biosynthesis	R-HSA-193993	5.629451e-01	0.250
Synthesis of DNA	R-HSA-69239	5.681109e-01	0.246
Signaling by LTK in cancer	R-HSA-9842640	5.724862e-01	0.242
Erythropoietin activates STAT5	R-HSA-9027283	5.724862e-01	0.242
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	5.724862e-01	0.242
Autointegration results in viral DNA circles	R-HSA-177539	5.724862e-01	0.242
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	5.724862e-01	0.242
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	5.724862e-01	0.242
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	5.724862e-01	0.242
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD	R-HSA-9865125	5.724862e-01	0.242
H139Hfs13* PPM1K causes a mild variant of MSUD	R-HSA-9912529	5.724862e-01	0.242
Abacavir transmembrane transport	R-HSA-2161517	5.724862e-01	0.242
Integration of viral DNA into host genomic DNA	R-HSA-175567	5.724862e-01	0.242
HDL clearance	R-HSA-8964011	5.724862e-01	0.242
VLDL assembly	R-HSA-8866423	5.724862e-01	0.242
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	5.782183e-01	0.238
RNA Polymerase III Transcription	R-HSA-74158	5.782183e-01	0.238
FLT3 signaling in disease	R-HSA-9682385	5.782183e-01	0.238
Metalloprotease DUBs	R-HSA-5689901	5.816252e-01	0.235
TRP channels	R-HSA-3295583	5.816252e-01	0.235
Platelet activation, signaling and aggregation	R-HSA-76002	5.833187e-01	0.234
Neuronal System	R-HSA-112316	5.892650e-01	0.230
G beta:gamma signalling through CDC42	R-HSA-8964616	5.893405e-01	0.230
Processing of Intronless Pre-mRNAs	R-HSA-77595	5.893405e-01	0.230
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	5.893405e-01	0.230
Synthesis of PG	R-HSA-1483148	5.893405e-01	0.230
Base Excision Repair	R-HSA-73884	5.893613e-01	0.230
Early SARS-CoV-2 Infection Events	R-HSA-9772572	5.908944e-01	0.228
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	5.927987e-01	0.227
Cleavage of the damaged purine	R-HSA-110331	5.961812e-01	0.225
TCR signaling	R-HSA-202403	6.007105e-01	0.221
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	6.008053e-01	0.221
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	6.008053e-01	0.221
Hedgehog 'off' state	R-HSA-5610787	6.008243e-01	0.221
Signaling by Hedgehog	R-HSA-5358351	6.014406e-01	0.221
Processive synthesis on the C-strand of the telomere	R-HSA-174414	6.023101e-01	0.220
EPHA-mediated growth cone collapse	R-HSA-3928663	6.023101e-01	0.220
Packaging Of Telomere Ends	R-HSA-171306	6.023101e-01	0.220
Signaling by BMP	R-HSA-201451	6.023101e-01	0.220
Triglyceride metabolism	R-HSA-8979227	6.053247e-01	0.218
Co-stimulation by CD28	R-HSA-389356	6.085446e-01	0.216
RUNX3 regulates WNT signaling	R-HSA-8951430	6.110159e-01	0.214
MET activates PI3K/AKT signaling	R-HSA-8851907	6.110159e-01	0.214
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	6.110159e-01	0.214
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	6.110159e-01	0.214
Regulation of PTEN localization	R-HSA-8948747	6.110159e-01	0.214
IFNG signaling activates MAPKs	R-HSA-9732724	6.110159e-01	0.214
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	6.110159e-01	0.214
PTK6 Expression	R-HSA-8849473	6.110159e-01	0.214
Activated NTRK2 signals through CDK5	R-HSA-9032845	6.110159e-01	0.214
Activated NTRK3 signals through PI3K	R-HSA-9603381	6.110159e-01	0.214
VLDL clearance	R-HSA-8964046	6.110159e-01	0.214
LDL remodeling	R-HSA-8964041	6.110159e-01	0.214
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	6.110159e-01	0.214
Cation-coupled Chloride cotransporters	R-HSA-426117	6.110159e-01	0.214
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	6.110159e-01	0.214
CHL1 interactions	R-HSA-447041	6.110159e-01	0.214
tRNA processing	R-HSA-72306	6.116746e-01	0.213
Depurination	R-HSA-73927	6.136793e-01	0.212
SLC-mediated transport of inorganic anions	R-HSA-9958790	6.136793e-01	0.212
Constitutive Signaling by EGFRvIII	R-HSA-5637810	6.145305e-01	0.211
Signaling by EGFRvIII in Cancer	R-HSA-5637812	6.145305e-01	0.211
PI3K events in ERBB2 signaling	R-HSA-1963642	6.145305e-01	0.211
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	6.145305e-01	0.211
Regulation of FZD by ubiquitination	R-HSA-4641263	6.145305e-01	0.211
Elevation of cytosolic Ca2+ levels	R-HSA-139853	6.145305e-01	0.211
Regulation of NPAS4 gene expression	R-HSA-9768759	6.145305e-01	0.211
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	6.145305e-01	0.211
Specification of primordial germ cells	R-HSA-9827857	6.145305e-01	0.211
Uptake and function of anthrax toxins	R-HSA-5210891	6.145305e-01	0.211
Regulation of mitotic cell cycle	R-HSA-453276	6.164348e-01	0.210
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	6.164348e-01	0.210
ESR-mediated signaling	R-HSA-8939211	6.295913e-01	0.201
Generic Transcription Pathway	R-HSA-212436	6.306225e-01	0.200
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	6.306988e-01	0.200
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	6.309372e-01	0.200
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	6.309372e-01	0.200
PLC beta mediated events	R-HSA-112043	6.333277e-01	0.198
Regulation of RUNX2 expression and activity	R-HSA-8939902	6.333277e-01	0.198
Ub-specific processing proteases	R-HSA-5689880	6.368875e-01	0.196
GAB1 signalosome	R-HSA-180292	6.385178e-01	0.195
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	6.385178e-01	0.195
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	6.385178e-01	0.195
RNA Polymerase III Transcription Termination	R-HSA-73980	6.385178e-01	0.195
Regulation of TP53 Activity through Methylation	R-HSA-6804760	6.385178e-01	0.195
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	6.385178e-01	0.195
ROBO receptors bind AKAP5	R-HSA-9010642	6.460751e-01	0.190
ALKBH3 mediated reversal of alkylation damage	R-HSA-112126	6.460751e-01	0.190
RSK activation	R-HSA-444257	6.460751e-01	0.190
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	6.460751e-01	0.190
phospho-PLA2 pathway	R-HSA-111995	6.460751e-01	0.190
Activated NTRK2 signals through PI3K	R-HSA-9028335	6.460751e-01	0.190
MET receptor recycling	R-HSA-8875656	6.460751e-01	0.190
Myoclonic epilepsy of Lafora	R-HSA-3785653	6.460751e-01	0.190
FGFR1b ligand binding and activation	R-HSA-190370	6.460751e-01	0.190
Interleukin-9 signaling	R-HSA-8985947	6.460751e-01	0.190
Adrenoceptors	R-HSA-390696	6.460751e-01	0.190
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	6.460751e-01	0.190
TGFBR3 PTM regulation	R-HSA-9839383	6.460751e-01	0.190
Alpha-defensins	R-HSA-1462054	6.460751e-01	0.190
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	6.460751e-01	0.190
Interleukin-23 signaling	R-HSA-9020933	6.460751e-01	0.190
Glycogen metabolism	R-HSA-8982491	6.472288e-01	0.189
Generation of second messenger molecules	R-HSA-202433	6.472288e-01	0.189
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	6.547573e-01	0.184
Activation of HOX genes during differentiation	R-HSA-5619507	6.547573e-01	0.184
Developmental Biology	R-HSA-1266738	6.568961e-01	0.183
Developmental Cell Lineages	R-HSA-9734767	6.576473e-01	0.182
Class I MHC mediated antigen processing & presentation	R-HSA-983169	6.593499e-01	0.181
Activation of BH3-only proteins	R-HSA-114452	6.602002e-01	0.180
Interleukin-37 signaling	R-HSA-9008059	6.602002e-01	0.180
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	6.613147e-01	0.180
Translesion Synthesis by POLH	R-HSA-110320	6.613147e-01	0.180
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	6.613147e-01	0.180
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	6.613147e-01	0.180
STING mediated induction of host immune responses	R-HSA-1834941	6.613147e-01	0.180
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	6.632609e-01	0.178
Adaptive Immune System	R-HSA-1280218	6.637182e-01	0.178
Orc1 removal from chromatin	R-HSA-68949	6.678525e-01	0.175
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	6.678525e-01	0.175
Transcriptional Regulation by NPAS4	R-HSA-9634815	6.678525e-01	0.175
Intracellular signaling by second messengers	R-HSA-9006925	6.700422e-01	0.174
VEGFA-VEGFR2 Pathway	R-HSA-4420097	6.719005e-01	0.173
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	6.729431e-01	0.172
Co-inhibition by PD-1	R-HSA-389948	6.746731e-01	0.171
MASTL Facilitates Mitotic Progression	R-HSA-2465910	6.779764e-01	0.169
Interleukin-21 signaling	R-HSA-9020958	6.779764e-01	0.169
mRNA Editing	R-HSA-75072	6.779764e-01	0.169
Regulation of signaling by NODAL	R-HSA-1433617	6.779764e-01	0.169
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	6.779764e-01	0.169
Regulation of CDH11 gene transcription	R-HSA-9762293	6.779764e-01	0.169
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	6.779764e-01	0.169
Defects in biotin (Btn) metabolism	R-HSA-3323169	6.779764e-01	0.169
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	6.780850e-01	0.169
EGFR downregulation	R-HSA-182971	6.780850e-01	0.169
Trafficking of AMPA receptors	R-HSA-399719	6.780850e-01	0.169
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	6.787894e-01	0.168
Signaling by FGFR1 in disease	R-HSA-5655302	6.787894e-01	0.168
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	6.817197e-01	0.166
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	6.817197e-01	0.166
VxPx cargo-targeting to cilium	R-HSA-5620916	6.829408e-01	0.166
Co-inhibition by CTLA4	R-HSA-389513	6.829408e-01	0.166
Signal transduction by L1	R-HSA-445144	6.829408e-01	0.166
Protein hydroxylation	R-HSA-9629569	6.829408e-01	0.166
Regulation of T cell activation by CD28 family	R-HSA-388841	6.844895e-01	0.165
Integration of energy metabolism	R-HSA-163685	6.846906e-01	0.165
Telomere Maintenance	R-HSA-157579	6.894348e-01	0.162
Cleavage of the damaged pyrimidine	R-HSA-110329	6.938108e-01	0.159
Depyrimidination	R-HSA-73928	6.938108e-01	0.159
Base-Excision Repair, AP Site Formation	R-HSA-73929	6.951925e-01	0.158
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	7.034220e-01	0.153
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	7.034220e-01	0.153
G-protein activation	R-HSA-202040	7.034220e-01	0.153
Zygotic genome activation (ZGA)	R-HSA-9819196	7.034220e-01	0.153
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	7.034220e-01	0.153
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	7.070039e-01	0.151
Regulation of CDH11 function	R-HSA-9762292	7.070039e-01	0.151
Binding and entry of HIV virion	R-HSA-173107	7.070039e-01	0.151
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	7.070039e-01	0.151
Receptor Mediated Mitophagy	R-HSA-8934903	7.070039e-01	0.151
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	7.070039e-01	0.151
MAPK3 (ERK1) activation	R-HSA-110056	7.070039e-01	0.151
Transcriptional regulation by RUNX1	R-HSA-8878171	7.073741e-01	0.150
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	7.082680e-01	0.150
Signaling by SCF-KIT	R-HSA-1433557	7.083238e-01	0.150
G-protein mediated events	R-HSA-112040	7.099263e-01	0.149
Nuclear RNA decay	R-HSA-9930044	7.117368e-01	0.148
FGFR1 mutant receptor activation	R-HSA-1839124	7.117368e-01	0.148
Cardiogenesis	R-HSA-9733709	7.117368e-01	0.148
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	7.117368e-01	0.148
PIP3 activates AKT signaling	R-HSA-1257604	7.189290e-01	0.143
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	7.209451e-01	0.142
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	7.209451e-01	0.142
EPHB-mediated forward signaling	R-HSA-3928662	7.223291e-01	0.141
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	7.227888e-01	0.141
Listeria monocytogenes entry into host cells	R-HSA-8876384	7.227888e-01	0.141
Glucocorticoid biosynthesis	R-HSA-194002	7.227888e-01	0.141
Serine metabolism	R-HSA-977347	7.227888e-01	0.141
Androgen biosynthesis	R-HSA-193048	7.227888e-01	0.141
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	7.233269e-01	0.141
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	7.275156e-01	0.138
Effects of PIP2 hydrolysis	R-HSA-114508	7.275156e-01	0.138
Interleukin-1 signaling	R-HSA-9020702	7.286742e-01	0.137
Cardiac conduction	R-HSA-5576891	7.304751e-01	0.136
Synthesis of PA	R-HSA-1483166	7.332234e-01	0.135
PECAM1 interactions	R-HSA-210990	7.334165e-01	0.135
LGI-ADAM interactions	R-HSA-5682910	7.334165e-01	0.135
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	7.334165e-01	0.135
Ionotropic activity of kainate receptors	R-HSA-451306	7.334165e-01	0.135
vRNA Synthesis	R-HSA-192814	7.334165e-01	0.135
vRNP Assembly	R-HSA-192905	7.334165e-01	0.135
Cholesterol biosynthesis via desmosterol	R-HSA-6807047	7.334165e-01	0.135
SARS-CoV-2 modulates autophagy	R-HSA-9754560	7.334165e-01	0.135
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	7.334165e-01	0.135
Suppression of apoptosis	R-HSA-9635465	7.334165e-01	0.135
CD163 mediating an anti-inflammatory response	R-HSA-9662834	7.334165e-01	0.135
Transport of RCbl within the body	R-HSA-9758890	7.334165e-01	0.135
Asymmetric localization of PCP proteins	R-HSA-4608870	7.358290e-01	0.133
Platelet Aggregation (Plug Formation)	R-HSA-76009	7.358290e-01	0.133
Fanconi Anemia Pathway	R-HSA-6783310	7.358290e-01	0.133
Hemostasis	R-HSA-109582	7.373956e-01	0.132
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.410758e-01	0.130
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	7.410758e-01	0.130
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	7.410758e-01	0.130
Signaling by KIT in disease	R-HSA-9669938	7.410758e-01	0.130
Cellular hexose transport	R-HSA-189200	7.410758e-01	0.130
LDL clearance	R-HSA-8964038	7.410758e-01	0.130
NOD1/2 Signaling Pathway	R-HSA-168638	7.426086e-01	0.129
Mitophagy	R-HSA-5205647	7.426086e-01	0.129
Signaling by NOTCH2	R-HSA-1980145	7.426086e-01	0.129
NPAS4 regulates expression of target genes	R-HSA-9768919	7.426086e-01	0.129
Degradation of beta-catenin by the destruction complex	R-HSA-195253	7.438469e-01	0.129
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	7.438469e-01	0.129
Infectious disease	R-HSA-5663205	7.479388e-01	0.126
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	7.488276e-01	0.126
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	7.488276e-01	0.126
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	7.488276e-01	0.126
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	7.488276e-01	0.126
Extension of Telomeres	R-HSA-180786	7.565894e-01	0.121
Sensing of DNA Double Strand Breaks	R-HSA-5693548	7.574494e-01	0.121
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	7.574494e-01	0.121
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	7.574494e-01	0.121
ERKs are inactivated	R-HSA-202670	7.574494e-01	0.121
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	7.574494e-01	0.121
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	7.574494e-01	0.121
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	7.574494e-01	0.121
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	7.574494e-01	0.121
FMO oxidises nucleophiles	R-HSA-217271	7.574494e-01	0.121
Regulation of PTEN mRNA translation	R-HSA-8943723	7.583201e-01	0.120
Mitochondrial mRNA modification	R-HSA-9937008	7.583201e-01	0.120
Interleukin-20 family signaling	R-HSA-8854691	7.583201e-01	0.120
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	7.583201e-01	0.120
Syndecan interactions	R-HSA-3000170	7.583201e-01	0.120
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	7.583201e-01	0.120
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	7.613302e-01	0.118
trans-Golgi Network Vesicle Budding	R-HSA-199992	7.648189e-01	0.116
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	7.648189e-01	0.116
TP53 Regulates Metabolic Genes	R-HSA-5628897	7.657695e-01	0.116
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	7.674611e-01	0.115
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	7.674611e-01	0.115
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	7.674611e-01	0.115
Signaling by VEGF	R-HSA-194138	7.674611e-01	0.115
Mitotic G1 phase and G1/S transition	R-HSA-453279	7.715961e-01	0.113
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	7.745611e-01	0.111
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	7.745611e-01	0.111
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	7.745611e-01	0.111
Mitochondrial RNA degradation	R-HSA-9836573	7.745611e-01	0.111
Plasma lipoprotein assembly	R-HSA-8963898	7.745611e-01	0.111
Maple Syrup Urine Disease	R-HSA-9865114	7.793171e-01	0.108
RUNX3 regulates p14-ARF	R-HSA-8951936	7.793171e-01	0.108
RUNX3 regulates NOTCH signaling	R-HSA-8941856	7.793171e-01	0.108
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	7.793171e-01	0.108
Serotonin clearance from the synaptic cleft	R-HSA-380615	7.793171e-01	0.108
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	7.793171e-01	0.108
Trafficking and processing of endosomal TLR	R-HSA-1679131	7.793171e-01	0.108
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	7.793171e-01	0.108
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	7.793171e-01	0.108
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	7.793171e-01	0.108
AKT phosphorylates targets in the cytosol	R-HSA-198323	7.793171e-01	0.108
OAS antiviral response	R-HSA-8983711	7.793171e-01	0.108
Interferon gamma signaling	R-HSA-877300	7.806392e-01	0.108
Voltage gated Potassium channels	R-HSA-1296072	7.839037e-01	0.106
Degradation of DVL	R-HSA-4641258	7.839037e-01	0.106
Degradation of CDH1	R-HSA-9766229	7.848758e-01	0.105
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	7.887069e-01	0.103
C-type lectin receptors (CLRs)	R-HSA-5621481	7.891564e-01	0.103
G protein gated Potassium channels	R-HSA-1296059	7.898395e-01	0.102
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	7.898395e-01	0.102
Activation of G protein gated Potassium channels	R-HSA-1296041	7.898395e-01	0.102
Laminin interactions	R-HSA-3000157	7.898395e-01	0.102
Acyl chain remodelling of PS	R-HSA-1482801	7.898395e-01	0.102
VEGFR2 mediated cell proliferation	R-HSA-5218921	7.898395e-01	0.102
Regulation of RAS by GAPs	R-HSA-5658442	7.959353e-01	0.099
PI3K/AKT Signaling in Cancer	R-HSA-2219528	7.965762e-01	0.099
Transcriptional regulation by RUNX3	R-HSA-8878159	7.976921e-01	0.098
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	7.986491e-01	0.098
Signaling by PTK6	R-HSA-8848021	7.986491e-01	0.098
Formation of axial mesoderm	R-HSA-9796292	7.992144e-01	0.097
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	7.992144e-01	0.097
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	7.992144e-01	0.097
FGFR1c ligand binding and activation	R-HSA-190373	7.992144e-01	0.097
IL-6-type cytokine receptor ligand interactions	R-HSA-6788467	7.992144e-01	0.097
PI5P Regulates TP53 Acetylation	R-HSA-6811555	7.992144e-01	0.097
rRNA modification in the mitochondrion	R-HSA-6793080	7.992144e-01	0.097
Replication of the SARS-CoV-1 genome	R-HSA-9682706	7.992144e-01	0.097
Pyruvate metabolism	R-HSA-70268	7.995951e-01	0.097
Signaling by EGFR in Cancer	R-HSA-1643713	8.041969e-01	0.095
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	8.041969e-01	0.095
Activation of NF-kappaB in B cells	R-HSA-1169091	8.065319e-01	0.093
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	8.074189e-01	0.093
Pentose phosphate pathway	R-HSA-71336	8.082715e-01	0.092
Plasma lipoprotein clearance	R-HSA-8964043	8.082715e-01	0.092
FOXO-mediated transcription	R-HSA-9614085	8.132568e-01	0.090
Uptake and actions of bacterial toxins	R-HSA-5339562	8.166761e-01	0.088
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV	R-HSA-9859138	8.173188e-01	0.088
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	8.173188e-01	0.088
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	8.173188e-01	0.088
Regulation of KIT signaling	R-HSA-1433559	8.173188e-01	0.088
Hydrolysis of LPC	R-HSA-1483115	8.173188e-01	0.088
Signaling by FGFR4 in disease	R-HSA-5655291	8.173188e-01	0.088
NRIF signals cell death from the nucleus	R-HSA-205043	8.173188e-01	0.088
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.173188e-01	0.088
Ciprofloxacin ADME	R-HSA-9793528	8.173188e-01	0.088
Acyl chain remodeling of CL	R-HSA-1482798	8.173188e-01	0.088
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	8.173188e-01	0.088
RNA Polymerase I Transcription Termination	R-HSA-73863	8.176750e-01	0.087
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	8.176750e-01	0.087
Insulin processing	R-HSA-264876	8.176750e-01	0.087
Signaling by NTRK2 (TRKB)	R-HSA-9006115	8.176750e-01	0.087
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	8.195602e-01	0.086
Regulation of RUNX3 expression and activity	R-HSA-8941858	8.195602e-01	0.086
PCP/CE pathway	R-HSA-4086400	8.200438e-01	0.086
Amino acids regulate mTORC1	R-HSA-9639288	8.263788e-01	0.083
Nucleotide biosynthesis	R-HSA-8956320	8.263788e-01	0.083
Extra-nuclear estrogen signaling	R-HSA-9009391	8.278889e-01	0.082
SLC transporter disorders	R-HSA-5619102	8.294579e-01	0.081
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	8.302778e-01	0.081
FLT3 Signaling	R-HSA-9607240	8.302778e-01	0.081
Telomere Extension By Telomerase	R-HSA-171319	8.303156e-01	0.081
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	8.303156e-01	0.081
Formation of the Early Elongation Complex	R-HSA-113418	8.303156e-01	0.081
Activation of kainate receptors upon glutamate binding	R-HSA-451326	8.303156e-01	0.081
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	8.303156e-01	0.081
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	8.303156e-01	0.081
Pre-NOTCH Transcription and Translation	R-HSA-1912408	8.311913e-01	0.080
G beta:gamma signalling through BTK	R-HSA-8964315	8.337917e-01	0.079
ERBB2 Regulates Cell Motility	R-HSA-6785631	8.337917e-01	0.079
Translesion synthesis by REV1	R-HSA-110312	8.337917e-01	0.079
Telomere C-strand synthesis initiation	R-HSA-174430	8.337917e-01	0.079
DNA Damage Reversal	R-HSA-73942	8.337917e-01	0.079
FASTK family proteins regulate processing and stability of mitochondrial RNAs	R-HSA-9837092	8.337917e-01	0.079
Lysosphingolipid and LPA receptors	R-HSA-419408	8.337917e-01	0.079
Transport and metabolism of PAPS	R-HSA-174362	8.337917e-01	0.079
Activation of BAD and translocation to mitochondria	R-HSA-111447	8.337917e-01	0.079
Spry regulation of FGF signaling	R-HSA-1295596	8.337917e-01	0.079
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	8.337917e-01	0.079
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	8.337917e-01	0.079
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	8.337917e-01	0.079
Signaling by Activin	R-HSA-1502540	8.337917e-01	0.079
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	8.356517e-01	0.078
HIV Transcription Initiation	R-HSA-167161	8.404440e-01	0.075
RNA Polymerase II Transcription Initiation	R-HSA-75953	8.404440e-01	0.075
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	8.404440e-01	0.075
Intra-Golgi traffic	R-HSA-6811438	8.404440e-01	0.075
mRNA Capping	R-HSA-72086	8.421602e-01	0.075
Regulation of CDH11 Expression and Function	R-HSA-9759475	8.421602e-01	0.075
Transcription of the HIV genome	R-HSA-167172	8.429173e-01	0.074
Amyloid fiber formation	R-HSA-977225	8.435329e-01	0.074
Paracetamol ADME	R-HSA-9753281	8.445066e-01	0.073
Signaling by NOTCH	R-HSA-157118	8.484211e-01	0.071
Translesion synthesis by POLI	R-HSA-5656121	8.487801e-01	0.071
Defective GALNT12 causes CRCS1	R-HSA-5083636	8.487801e-01	0.071
Defective GALNT3 causes HFTC	R-HSA-5083625	8.487801e-01	0.071
WNT5A-dependent internalization of FZD4	R-HSA-5099900	8.487801e-01	0.071
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	8.487801e-01	0.071
Fructose catabolism	R-HSA-70350	8.487801e-01	0.071
Differentiation of T cells	R-HSA-9945266	8.487801e-01	0.071
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	8.487801e-01	0.071
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	8.487801e-01	0.071
Attachment and Entry	R-HSA-9678110	8.487801e-01	0.071
Negative regulation of FLT3	R-HSA-9706369	8.487801e-01	0.071
Virus Assembly and Release	R-HSA-168268	8.487801e-01	0.071
Cytosolic tRNA aminoacylation	R-HSA-379716	8.500790e-01	0.071
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	8.500790e-01	0.071
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	8.507354e-01	0.070
Intrinsic Pathway for Apoptosis	R-HSA-109606	8.529560e-01	0.069
Detoxification of Reactive Oxygen Species	R-HSA-3299685	8.529560e-01	0.069
Beta-catenin independent WNT signaling	R-HSA-3858494	8.530301e-01	0.069
RNA Polymerase III Transcription Initiation	R-HSA-76046	8.532494e-01	0.069
SHC1 events in ERBB2 signaling	R-HSA-1250196	8.532494e-01	0.069
GABA synthesis, release, reuptake and degradation	R-HSA-888590	8.532494e-01	0.069
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.532494e-01	0.069
COPII-mediated vesicle transport	R-HSA-204005	8.582275e-01	0.066
Cyclin E associated events during G1/S transition	R-HSA-69202	8.582275e-01	0.066
RNA Polymerase II Promoter Escape	R-HSA-73776	8.592030e-01	0.066
Response of Mtb to phagocytosis	R-HSA-9637690	8.592030e-01	0.066
GRB2 events in ERBB2 signaling	R-HSA-1963640	8.624177e-01	0.064
Translesion synthesis by POLK	R-HSA-5655862	8.624177e-01	0.064
Transcriptional regulation of testis differentiation	R-HSA-9690406	8.624177e-01	0.064
Passive transport by Aquaporins	R-HSA-432047	8.624177e-01	0.064
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	8.636232e-01	0.064
Cargo concentration in the ER	R-HSA-5694530	8.636232e-01	0.064
Downstream signal transduction	R-HSA-186763	8.636232e-01	0.064
Amine ligand-binding receptors	R-HSA-375280	8.678362e-01	0.062
Netrin-1 signaling	R-HSA-373752	8.678362e-01	0.062
Inwardly rectifying K+ channels	R-HSA-1296065	8.733203e-01	0.059
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	8.733203e-01	0.059
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	8.748261e-01	0.058
Glycogen storage diseases	R-HSA-3229121	8.748261e-01	0.058
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	8.748261e-01	0.058
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	8.748261e-01	0.058
Replication of the SARS-CoV-2 genome	R-HSA-9694686	8.748261e-01	0.058
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	8.759990e-01	0.057
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	8.759990e-01	0.057
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	8.759990e-01	0.057
Interleukin-1 family signaling	R-HSA-446652	8.766128e-01	0.057
Stimuli-sensing channels	R-HSA-2672351	8.776266e-01	0.057
Ca2+ pathway	R-HSA-4086398	8.788368e-01	0.056
Ion channel transport	R-HSA-983712	8.817213e-01	0.055
G-protein beta:gamma signalling	R-HSA-397795	8.823785e-01	0.054
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	8.823785e-01	0.054
tRNA Aminoacylation	R-HSA-379724	8.829499e-01	0.054
mRNA Splicing - Minor Pathway	R-HSA-72165	8.837112e-01	0.054
Regulation of pyruvate metabolism	R-HSA-9861718	8.837112e-01	0.054
Signaling by FGFR in disease	R-HSA-1226099	8.851143e-01	0.053
Signaling by ERBB4	R-HSA-1236394	8.851143e-01	0.053
Signaling by NOTCH4	R-HSA-9013694	8.851143e-01	0.053
G beta:gamma signalling through PLC beta	R-HSA-418217	8.861161e-01	0.053
Presynaptic function of Kainate receptors	R-HSA-500657	8.861161e-01	0.053
FGFR1 ligand binding and activation	R-HSA-190242	8.861161e-01	0.053
PKA activation	R-HSA-163615	8.861161e-01	0.053
Apoptotic factor-mediated response	R-HSA-111471	8.861161e-01	0.053
Metabolism of proteins	R-HSA-392499	8.874706e-01	0.052
Post-translational protein phosphorylation	R-HSA-8957275	8.878557e-01	0.052
Acyl chain remodelling of PC	R-HSA-1482788	8.908339e-01	0.050
PI-3K cascade:FGFR3	R-HSA-5654710	8.963884e-01	0.048
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	8.963884e-01	0.048
Signaling by FGFR2 IIIa TM	R-HSA-8851708	8.963884e-01	0.048
Pyrimidine biosynthesis	R-HSA-500753	8.963884e-01	0.048
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	8.963884e-01	0.048
Regulation of signaling by CBL	R-HSA-912631	8.963884e-01	0.048
Maturation of nucleoprotein	R-HSA-9694631	8.963884e-01	0.048
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	8.963884e-01	0.048
UCH proteinases	R-HSA-5689603	8.968358e-01	0.047
ABC-family proteins mediated transport	R-HSA-382556	8.980111e-01	0.047
Post-translational protein modification	R-HSA-597592	8.983910e-01	0.047
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	8.987217e-01	0.046
Signal amplification	R-HSA-392518	8.987217e-01	0.046
eNOS activation	R-HSA-203615	8.987217e-01	0.046
Hyaluronan metabolism	R-HSA-2142845	8.987217e-01	0.046
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	8.987217e-01	0.046
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.043401e-01	0.044
Neurotransmitter release cycle	R-HSA-112310	9.043966e-01	0.044
Downstream TCR signaling	R-HSA-202424	9.043966e-01	0.044
PI-3K cascade:FGFR4	R-HSA-5654720	9.057347e-01	0.043
Glycogen synthesis	R-HSA-3322077	9.057347e-01	0.043
Acyl chain remodelling of PI	R-HSA-1482922	9.057347e-01	0.043
Creatine metabolism	R-HSA-71288	9.057347e-01	0.043
Regulation of Apoptosis	R-HSA-169911	9.060754e-01	0.043
Acyl chain remodelling of PE	R-HSA-1482839	9.060754e-01	0.043
PERK regulates gene expression	R-HSA-381042	9.060754e-01	0.043
Insulin receptor signalling cascade	R-HSA-74751	9.074719e-01	0.042
Azathioprine ADME	R-HSA-9748787	9.104438e-01	0.041
PI3K Cascade	R-HSA-109704	9.104438e-01	0.041
Regulation of TP53 Degradation	R-HSA-6804757	9.129272e-01	0.040
RUNX2 regulates bone development	R-HSA-8941326	9.129272e-01	0.040
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.142384e-01	0.039
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	9.142384e-01	0.039
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	9.142384e-01	0.039
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.142384e-01	0.039
PKA-mediated phosphorylation of CREB	R-HSA-111931	9.142384e-01	0.039
Vitamin C (ascorbate) metabolism	R-HSA-196836	9.142384e-01	0.039
Basigin interactions	R-HSA-210991	9.142384e-01	0.039
Acyl chain remodelling of PG	R-HSA-1482925	9.142384e-01	0.039
Phospholipid metabolism	R-HSA-1483257	9.143483e-01	0.039
Hedgehog ligand biogenesis	R-HSA-5358346	9.161918e-01	0.038
Signaling by FGFR2	R-HSA-5654738	9.172000e-01	0.038
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.216015e-01	0.035
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	9.219755e-01	0.035
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.219755e-01	0.035
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	9.219755e-01	0.035
Glutathione synthesis and recycling	R-HSA-174403	9.219755e-01	0.035
Signaling by NTRK3 (TRKC)	R-HSA-9034015	9.219755e-01	0.035
Mitochondrial calcium ion transport	R-HSA-8949215	9.219755e-01	0.035
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	9.219755e-01	0.035
Attachment and Entry	R-HSA-9694614	9.219755e-01	0.035
Ribavirin ADME	R-HSA-9755088	9.219755e-01	0.035
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.252462e-01	0.034
Regulation of PTEN stability and activity	R-HSA-8948751	9.266899e-01	0.033
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.282848e-01	0.032
PI-3K cascade:FGFR1	R-HSA-5654689	9.290150e-01	0.032
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	9.290150e-01	0.032
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	9.290150e-01	0.032
Fructose metabolism	R-HSA-5652084	9.290150e-01	0.032
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	9.307704e-01	0.031
Stabilization of p53	R-HSA-69541	9.307704e-01	0.031
Regulation of TP53 Expression and Degradation	R-HSA-6806003	9.307704e-01	0.031
Transcriptional regulation by RUNX2	R-HSA-8878166	9.328524e-01	0.030
PPARA activates gene expression	R-HSA-1989781	9.342002e-01	0.030
Termination of O-glycan biosynthesis	R-HSA-977068	9.354197e-01	0.029
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	9.354197e-01	0.029
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	9.354197e-01	0.029
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	9.354197e-01	0.029
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	9.354197e-01	0.029
Organic anion transport by SLCO transporters	R-HSA-879518	9.354197e-01	0.029
Carnitine shuttle	R-HSA-200425	9.354197e-01	0.029
ABC transporters in lipid homeostasis	R-HSA-1369062	9.354197e-01	0.029
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.357320e-01	0.029
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	9.359068e-01	0.029
HIV Transcription Elongation	R-HSA-167169	9.359068e-01	0.029
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	9.359068e-01	0.029
G alpha (z) signalling events	R-HSA-418597	9.359681e-01	0.029
Hedgehog 'on' state	R-HSA-5632684	9.395967e-01	0.027
Metabolism of porphyrins	R-HSA-189445	9.395967e-01	0.027
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.396390e-01	0.027
Signaling by FGFR1	R-HSA-5654736	9.401891e-01	0.027
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.406803e-01	0.027
Hh mutants are degraded by ERAD	R-HSA-5362768	9.406803e-01	0.027
Thromboxane signalling through TP receptor	R-HSA-428930	9.412469e-01	0.026
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	9.412469e-01	0.026
Synthesis of dolichyl-phosphate	R-HSA-446199	9.412469e-01	0.026
Complex III assembly	R-HSA-9865881	9.412469e-01	0.026
TNFs bind their physiological receptors	R-HSA-5669034	9.412469e-01	0.026
Signaling by FGFR	R-HSA-190236	9.436652e-01	0.025
IRS-mediated signalling	R-HSA-112399	9.441510e-01	0.025
Degradation of CRY and PER proteins	R-HSA-9932298	9.451147e-01	0.025
Scavenging by Class A Receptors	R-HSA-3000480	9.451147e-01	0.025
PI-3K cascade:FGFR2	R-HSA-5654695	9.465486e-01	0.024
Beta-oxidation of pristanoyl-CoA	R-HSA-389887	9.465486e-01	0.024
Hyaluronan degradation	R-HSA-2160916	9.465486e-01	0.024
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.465486e-01	0.024
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.465486e-01	0.024
Diseases of carbohydrate metabolism	R-HSA-5663084	9.466980e-01	0.024
Formation of the cornified envelope	R-HSA-6809371	9.474210e-01	0.023
Activation of GABAB receptors	R-HSA-991365	9.492321e-01	0.023
GABA B receptor activation	R-HSA-977444	9.492321e-01	0.023
Pre-NOTCH Expression and Processing	R-HSA-1912422	9.494260e-01	0.023
Metabolism of steroids	R-HSA-8957322	9.497987e-01	0.022
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.513536e-01	0.022
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.513722e-01	0.022
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	9.513722e-01	0.022
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	9.513722e-01	0.022
MET activates PTK2 signaling	R-HSA-8874081	9.513722e-01	0.022
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.513722e-01	0.022
Attachment of bacteria to epithelial cells	R-HSA-9638630	9.513722e-01	0.022
Urea cycle	R-HSA-70635	9.513722e-01	0.022
Sphingolipid catabolism	R-HSA-9845614	9.513722e-01	0.022
Abacavir ADME	R-HSA-2161522	9.513722e-01	0.022
Asparagine N-linked glycosylation	R-HSA-446203	9.519507e-01	0.021
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.530537e-01	0.021
Signaling by FGFR4	R-HSA-5654743	9.530537e-01	0.021
Signaling by Nuclear Receptors	R-HSA-9006931	9.531628e-01	0.021
ER-Phagosome pathway	R-HSA-1236974	9.533886e-01	0.021
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.544717e-01	0.020
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	9.557608e-01	0.020
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	9.557608e-01	0.020
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.557608e-01	0.020
Signaling by FGFR3 in disease	R-HSA-5655332	9.557608e-01	0.020
Triglyceride biosynthesis	R-HSA-75109	9.557608e-01	0.020
Synthesis of PE	R-HSA-1483213	9.557608e-01	0.020
CD28 dependent PI3K/Akt signaling	R-HSA-389357	9.557608e-01	0.020
Proteasome assembly	R-HSA-9907900	9.565994e-01	0.019
Cyclin D associated events in G1	R-HSA-69231	9.565994e-01	0.019
G1 Phase	R-HSA-69236	9.565994e-01	0.019
IRS-related events triggered by IGF1R	R-HSA-2428928	9.576815e-01	0.019
Aquaporin-mediated transport	R-HSA-445717	9.576815e-01	0.019
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.586573e-01	0.018
HIV elongation arrest and recovery	R-HSA-167287	9.597535e-01	0.018
Pausing and recovery of HIV elongation	R-HSA-167290	9.597535e-01	0.018
Insulin receptor recycling	R-HSA-77387	9.597535e-01	0.018
Negative regulation of FGFR3 signaling	R-HSA-5654732	9.597535e-01	0.018
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.597535e-01	0.018
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.598877e-01	0.018
Signaling by FGFR3	R-HSA-5654741	9.598877e-01	0.018
Protein localization	R-HSA-9609507	9.603759e-01	0.018
Mitochondrial protein import	R-HSA-1268020	9.605480e-01	0.017
NCAM signaling for neurite out-growth	R-HSA-375165	9.605480e-01	0.017
Signaling by PDGF	R-HSA-186797	9.605480e-01	0.017
Integrin cell surface interactions	R-HSA-216083	9.612321e-01	0.017
Cholesterol biosynthesis	R-HSA-191273	9.612321e-01	0.017
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.629363e-01	0.016
Negative regulation of the PI3K/AKT network	R-HSA-199418	9.630996e-01	0.016
Signaling by Insulin receptor	R-HSA-74752	9.632914e-01	0.016
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.632914e-01	0.016
Signaling by CSF3 (G-CSF)	R-HSA-9674555	9.633861e-01	0.016
Downstream signaling of activated FGFR3	R-HSA-5654708	9.633861e-01	0.016
Regulation of gene expression in beta cells	R-HSA-210745	9.633861e-01	0.016
Negative regulation of FGFR4 signaling	R-HSA-5654733	9.633861e-01	0.016
Glucagon-type ligand receptors	R-HSA-420092	9.633861e-01	0.016
IGF1R signaling cascade	R-HSA-2428924	9.657420e-01	0.015
DAP12 signaling	R-HSA-2424491	9.666910e-01	0.015
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.666910e-01	0.015
Downstream signaling of activated FGFR4	R-HSA-5654716	9.666910e-01	0.015
Neurotransmitter clearance	R-HSA-112311	9.666910e-01	0.015
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	9.674810e-01	0.014
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	9.680904e-01	0.014
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.696978e-01	0.013
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.702861e-01	0.013
p53-Dependent G1 DNA Damage Response	R-HSA-69563	9.708031e-01	0.013
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	9.708031e-01	0.013
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.724333e-01	0.012
Potassium Channels	R-HSA-1296071	9.729433e-01	0.012
Signaling by FGFR2 in disease	R-HSA-5655253	9.730474e-01	0.012
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	9.735223e-01	0.012
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.745967e-01	0.011
Negative regulation of FGFR1 signaling	R-HSA-5654726	9.749221e-01	0.011
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.749221e-01	0.011
The phototransduction cascade	R-HSA-2514856	9.751247e-01	0.011
Disease	R-HSA-1643685	9.751248e-01	0.011
Vpu mediated degradation of CD4	R-HSA-180534	9.771862e-01	0.010
Glucagon signaling in metabolic regulation	R-HSA-163359	9.771862e-01	0.010
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.771862e-01	0.010
Synthesis of bile acids and bile salts	R-HSA-192105	9.775428e-01	0.010
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.785467e-01	0.009
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.792461e-01	0.009
Calnexin/calreticulin cycle	R-HSA-901042	9.792461e-01	0.009
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	9.792461e-01	0.009
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	9.792461e-01	0.009
RA biosynthesis pathway	R-HSA-5365859	9.792461e-01	0.009
Negative regulation of FGFR2 signaling	R-HSA-5654727	9.792461e-01	0.009
Disorders of transmembrane transporters	R-HSA-5619115	9.803998e-01	0.009
Parasite infection	R-HSA-9664407	9.804680e-01	0.009
Leishmania phagocytosis	R-HSA-9664417	9.804680e-01	0.009
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.804680e-01	0.009
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	9.811201e-01	0.008
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	9.811201e-01	0.008
Downstream signaling of activated FGFR2	R-HSA-5654696	9.811201e-01	0.008
Downstream signaling of activated FGFR1	R-HSA-5654687	9.811201e-01	0.008
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.811201e-01	0.008
Vif-mediated degradation of APOBEC3G	R-HSA-180585	9.828250e-01	0.008
Lysosome Vesicle Biogenesis	R-HSA-432720	9.828250e-01	0.008
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.828250e-01	0.008
GPVI-mediated activation cascade	R-HSA-114604	9.828250e-01	0.008
FGFR2 mutant receptor activation	R-HSA-1839126	9.828250e-01	0.008
Degradation of AXIN	R-HSA-4641257	9.843760e-01	0.007
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	9.843760e-01	0.007
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.843760e-01	0.007
SLC-mediated transport of organic cations	R-HSA-549127	9.843760e-01	0.007
Metabolism of folate and pterines	R-HSA-196757	9.843760e-01	0.007
Dectin-2 family	R-HSA-5621480	9.846917e-01	0.007
Innate Immune System	R-HSA-168249	9.850560e-01	0.007
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.857871e-01	0.006
Biofilm formation	R-HSA-9931953	9.857871e-01	0.006
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	9.857871e-01	0.006
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.858909e-01	0.006
Peroxisomal protein import	R-HSA-9033241	9.869984e-01	0.006
Regulation of beta-cell development	R-HSA-186712	9.869984e-01	0.006
RAS processing	R-HSA-9648002	9.870707e-01	0.006
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.870707e-01	0.006
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.870707e-01	0.006
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.870707e-01	0.006
GABA receptor activation	R-HSA-977443	9.880211e-01	0.005
Glutathione conjugation	R-HSA-156590	9.880211e-01	0.005
Antigen processing-Cross presentation	R-HSA-1236975	9.881270e-01	0.005
Negative regulation of NOTCH4 signaling	R-HSA-9604323	9.882385e-01	0.005
rRNA processing in the mitochondrion	R-HSA-8868766	9.882385e-01	0.005
Interleukin-2 family signaling	R-HSA-451927	9.882385e-01	0.005
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.882385e-01	0.005
Mitochondrial protein degradation	R-HSA-9837999	9.883739e-01	0.005
Collagen formation	R-HSA-1474290	9.883739e-01	0.005
Formation of paraxial mesoderm	R-HSA-9793380	9.889652e-01	0.005
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	9.893009e-01	0.005
Maturation of spike protein	R-HSA-9694548	9.893009e-01	0.005
Bile acid and bile salt metabolism	R-HSA-194068	9.895771e-01	0.005
Neddylation	R-HSA-8951664	9.900459e-01	0.004
Degradation of GLI1 by the proteasome	R-HSA-5610780	9.902674e-01	0.004
Degradation of GLI2 by the proteasome	R-HSA-5610783	9.902674e-01	0.004
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	9.902674e-01	0.004
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.902674e-01	0.004
Heme biosynthesis	R-HSA-189451	9.902674e-01	0.004
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.905536e-01	0.004
Complex I biogenesis	R-HSA-6799198	9.906405e-01	0.004
G1/S DNA Damage Checkpoints	R-HSA-69615	9.906405e-01	0.004
Extracellular matrix organization	R-HSA-1474244	9.907249e-01	0.004
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.911467e-01	0.004
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	9.911467e-01	0.004
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.914813e-01	0.004
Defensins	R-HSA-1461973	9.919465e-01	0.004
Cellular response to hypoxia	R-HSA-1234174	9.920665e-01	0.003
Parasitic Infection Pathways	R-HSA-9824443	9.920904e-01	0.003
Leishmania infection	R-HSA-9658195	9.920904e-01	0.003
DAP12 interactions	R-HSA-2172127	9.926741e-01	0.003
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	9.926741e-01	0.003
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.926741e-01	0.003
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.926741e-01	0.003
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.932103e-01	0.003
Metabolism of steroid hormones	R-HSA-196071	9.932792e-01	0.003
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.933235e-01	0.003
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.933361e-01	0.003
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	9.933361e-01	0.003
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	9.933361e-01	0.003
Somitogenesis	R-HSA-9824272	9.933361e-01	0.003
Degradation of cysteine and homocysteine	R-HSA-1614558	9.933361e-01	0.003
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.933361e-01	0.003
O-linked glycosylation of mucins	R-HSA-913709	9.938155e-01	0.003
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.938575e-01	0.003
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.944860e-01	0.002
Synthesis of PC	R-HSA-1483191	9.944860e-01	0.002
Degradation of the extracellular matrix	R-HSA-1474228	9.945108e-01	0.002
GPER1 signaling	R-HSA-9634597	9.949843e-01	0.002
Plasma lipoprotein remodeling	R-HSA-8963899	9.949843e-01	0.002
Metabolism of cofactors	R-HSA-8978934	9.951850e-01	0.002
Chemokine receptors bind chemokines	R-HSA-380108	9.954376e-01	0.002
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.955716e-01	0.002
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.958500e-01	0.002
Branched-chain amino acid catabolism	R-HSA-70895	9.962251e-01	0.002
Complex IV assembly	R-HSA-9864848	9.962251e-01	0.002
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.962251e-01	0.002
Iron uptake and transport	R-HSA-917937	9.965575e-01	0.001
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.965948e-01	0.001
Translation of Structural Proteins	R-HSA-9694635	9.970914e-01	0.001
ABC transporter disorders	R-HSA-5619084	9.973269e-01	0.001
Interleukin-10 signaling	R-HSA-6783783	9.973269e-01	0.001
FCERI mediated NF-kB activation	R-HSA-2871837	9.978019e-01	0.001
Regulation of insulin secretion	R-HSA-422356	9.978659e-01	0.001
Role of phospholipids in phagocytosis	R-HSA-2029485	9.980574e-01	0.001
Amino acid transport across the plasma membrane	R-HSA-352230	9.982312e-01	0.001
Peptide hormone metabolism	R-HSA-2980736	9.983242e-01	0.001
Signaling by Retinoic Acid	R-HSA-5362517	9.983912e-01	0.001
Metabolism of polyamines	R-HSA-351202	9.983912e-01	0.001
Peroxisomal lipid metabolism	R-HSA-390918	9.983930e-01	0.001
Gastrulation	R-HSA-9758941	9.984275e-01	0.001
Collagen degradation	R-HSA-1442490	9.985367e-01	0.001
Class B/2 (Secretin family receptors)	R-HSA-373080	9.991165e-01	0.000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.991716e-01	0.000
SLC-mediated transport of amino acids	R-HSA-9958863	9.991716e-01	0.000
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.992465e-01	0.000
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.993173e-01	0.000
FCERI mediated MAPK activation	R-HSA-2871796	9.993505e-01	0.000
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.994331e-01	0.000
ECM proteoglycans	R-HSA-3000178	9.994331e-01	0.000
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.995658e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.995660e-01	0.000
Keratinization	R-HSA-6805567	9.997075e-01	0.000
SLC-mediated transport of organic anions	R-HSA-9955298	9.997082e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.997331e-01	0.000
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.997346e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.998365e-01	0.000
Sulfur amino acid metabolism	R-HSA-1614635	9.998758e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.998816e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.998898e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999069e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.999286e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999286e-01	0.000
G alpha (q) signalling events	R-HSA-416476	9.999408e-01	0.000
FCGR activation	R-HSA-2029481	9.999419e-01	0.000
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.999520e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.999603e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.999672e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999735e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999796e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999827e-01	0.000
G alpha (s) signalling events	R-HSA-418555	9.999828e-01	0.000
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999831e-01	0.000
Arachidonate metabolism	R-HSA-2142753	9.999853e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999867e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999895e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999896e-01	0.000
Drug ADME	R-HSA-9748784	9.999904e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999929e-01	0.000
Initial triggering of complement	R-HSA-166663	9.999941e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999959e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999962e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999966e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999973e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.999976e-01	0.000
Regulation of Complement cascade	R-HSA-977606	9.999981e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999985e-01	0.000
Infection with Enterobacteria	R-HSA-9640148	9.999987e-01	0.000
Transport of small molecules	R-HSA-382551	9.999988e-01	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.999989e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.999991e-01	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	9.999992e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.999996e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.999996e-01	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	9.999996e-01	0.000
Complement cascade	R-HSA-166658	9.999998e-01	0.000
Bacterial Infection Pathways	R-HSA-9824439	9.999999e-01	0.000
GPCR downstream signalling	R-HSA-388396	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000