ROCK2

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
O14950 S20 Sugiyama MYL12B MRLC2 MYLC2B _MSSKKAKTKTTKKRPQRAtsNVFAMFDQSQIQEFKEAFNM
O14950 T19 Sugiyama MYL12B MRLC2 MYLC2B __MSSKKAKTKTTKKRPQRAtsNVFAMFDQSQIQEFKEAFN
O14974 S692 Sugiyama PPP1R12A MBS MYPT1 PVRDEEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIG
O14974 S695 Sugiyama PPP1R12A MBS MYPT1 DEEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSR
O14974 S852 EPSD PPP1R12A MBS MYPT1 EDKSQPKSIRERRRPREKRRstGVSFWtQDsDENEQEQQsD
O14974 T696 GPS6|EPSD|PSP|Sugiyama PPP1R12A MBS MYPT1 EEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSRS
O14974 T700 Sugiyama PPP1R12A MBS MYPT1 sQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSRSTRTR
O14974 T853 SIGNOR|iPTMNet|EPSD PPP1R12A MBS MYPT1 DKSQPKSIRERRRPREKRRstGVSFWtQDsDENEQEQQsDt
O15212 T107 Sugiyama PFDN6 HKE2 PFD6 IKRYESQLRDLERQsEQQREtLAQLQQEFQRAQAAKAGAPG
O15446 T433 Sugiyama POLR1G ASE1 CAST CD3EAP PAF49 EPQAAPtstKKKKKKKERGHtVtEPIQPLEPELPGEGQPEA
O15446 T435 Sugiyama POLR1G ASE1 CAST CD3EAP PAF49 QAAPtstKKKKKKKERGHtVtEPIQPLEPELPGEGQPEARA
O43175 T78 Sugiyama PHGDH PGDH3 KVTADVINAAEKLQVVGRAGtGVDNVDLEAAtRKGILVMNT
O43318 S439 Sugiyama MAP3K7 TAK1 GNILDVPEIVISGNGQPRRRsIQDLtVtGTEPGQVssRsss
O60814 S37 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
O60814 S39 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
O75116 S134 Sugiyama ROCK2 KIAA0619 SQKVYAMKLLSKFEMIKRSDsAFFWEERDIMAFANSPWVVQ
O75116 S1366 PSP ROCK2 KIAA0619 KKIPKKPPAPDPFARssPRTsMKIQQNQsIRRPsRQLAPNK
O75116 S1374 PSP ROCK2 KIAA0619 APDPFARssPRTsMKIQQNQsIRRPsRQLAPNKPS______
O75116 S1379 PSP ROCK2 KIAA0619 ARssPRTsMKIQQNQsIRRPsRQLAPNKPS___________
O75116 S425 Sugiyama ROCK2 KIAA0619 GNQLPFIGFTYYRENLLLsDsPSCRETDSIQSRKNEESQEI
O75116 S535 Sugiyama ROCK2 KIAA0619 YQRKADHEADKKRNLENDVNsLKDQLEDLKKRNQNSQISTE
O75116 T235 Sugiyama ROCK2 KIAA0619 VKPDNMLLDKHGHLKLADFGtCMKMDETGMVHCDtAVGTPD
O75116 T489 Sugiyama ROCK2 KIAA0619 KCKSVNTRLEKTAKELEEEItLRKSVESALRQLEREKALLQ
O75400 T948 Sugiyama PRPF40A FBP11 FLAF1 FNBP3 HIP10 HYPA HSPC225 GNWDtsGsELsEGELEKRRRtLLEQLDDDQ___________
O75534 T761 Sugiyama CSDE1 D1S155E KIAA0885 NRU UNR GPKAVAAPRPDRLVNRLKNItLDDAsAPRLMVLRQPRGPDN
O75665 S899 Sugiyama OFD1 CXorf5 EEKIREQQVKERRQREERRQsNLQEVLERERRELEKLyQER
O95218 S181 Sugiyama ZRANB2 ZIS ZNF265 DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
O95644 S241 EPSD|PSP NFATC1 NFAT2 NFATC FPRGLGACtLLGsPRHsPstsPRAsVTEESWLGARssRPAs
P00338 T322 Sugiyama LDHA PIG19 DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P06733 T19 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 __MSILKIHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGA
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06733 T26 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 IHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEA
P07195 T302 Sugiyama LDHB YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07737 T65 Sugiyama PFN1 PAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQDGEFs
P07737 Y60 Sugiyama PFN1 FVNITPAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQ
P07900 S63 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPN
P07900 S641 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DNstMGyMAAKKHLEINPDHsIIEtLRQKAEADKNDKSVKD
P07900 T645 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MGyMAAKKHLEINPDHsIIEtLRQKAEADKNDKSVKDLVIL
P08238 S45 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 S58 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPN
P08238 T85 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB LDsGKELKIDIIPNPQERtLtLVDtGIGMtKADLINNLGtI
P08238 T89 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB KELKIDIIPNPQERtLtLVDtGIGMtKADLINNLGtIAKSG
P08670 S39 GPS6|EPSD VIM GtAsRPsssRsYVttsTRtYsLGsALRPstsRsLyAssPGG
P08670 S72 GPS6|ELM|PSP VIM LyAssPGGVyAtRssAVRLRssVPGVRLLQDsVDFsLADAI
P08670 T327 Sugiyama VIM DALRQAKQESTEYRRQVQsLtCEVDALKGtNEsLERQMREM
P09382 T58 Sugiyama LGALS1 DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P10412 S36 Sugiyama H1-4 H1F4 HIST1H1E EKtPVKKKARKsAGAAKRKAsGPPVsELItKAVAASKERsG
P10412 S41 Sugiyama H1-4 H1F4 HIST1H1E KKKARKsAGAAKRKAsGPPVsELItKAVAASKERsGVsLAA
P10412 S55 Sugiyama H1-4 H1F4 HIST1H1E AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P10916 S15 PSP MYL2 MLC2 ______MAPKKAKKRAGGANsNVFsMFEQTQIQEFKEAFTI
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142 T158 Sugiyama HSPA8 HSC70 HSP73 HSPA10 tVTNAVVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtA
P11142 T163 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11940 T191 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 GRFKSRKEREAELGARAKEFtNVyIKNFGEDMDDERLKDLF
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 T5 Sugiyama EEF2 EF2 ________________MVNFtVDQIRAIMDKKANIRNMsVI
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14136 S13 ELM GFAP ________MERRRItsAARRsYVssGEMMVGGLAPGRRLGP
P14136 S38 ELM GFAP GEMMVGGLAPGRRLGPGTRLsLARMPPPLPTRVDFSLAGAL
P14136 T7 ELM GFAP ______________MERRRItsAARRsYVssGEMMVGGLAP
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14598 S345 PSP NCF1 NOXO2 SH3PXD1A RRNsVRFLQQRRRQARPGPQsPGsPLEEERQtQRsKPQPAV
P14618 S202 Sugiyama PKM OIP3 PK2 PK3 PKM2 SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs
P14618 T45 Sugiyama PKM OIP3 PK2 PK3 PKM2 TFLEHMCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMI
P14618 T50 Sugiyama PKM OIP3 PK2 PK3 PKM2 MCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMIKsGMN
P14625 S106 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625 S515 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 GVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQ
P14625 T519 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 DHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQDKIy
P15880 T202 Sugiyama RPS2 RPS4 CKVTGRCGsVLVRLIPAPRGtGIVsAPVPKKLLMMAGIDDC
P16402 S37 Sugiyama H1-3 H1F3 HIST1H1D KtPVKKKAKKAGATAGKRKAsGPPVsELItKAVAASKERsG
P16402 S42 Sugiyama H1-3 H1F3 HIST1H1D KKAKKAGATAGKRKAsGPPVsELItKAVAASKERsGVsLAA
P16402 S56 Sugiyama H1-3 H1F3 HIST1H1D AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403 S36 Sugiyama H1-2 H1F2 HIST1H1C EKAPVKKKAAKKAGGtPRKAsGPPVsELItKAVAASKERsG
P16403 S41 Sugiyama H1-2 H1F2 HIST1H1C KKKAAKKAGGtPRKAsGPPVsELItKAVAASKERsGVsLAA
P16403 S55 Sugiyama H1-2 H1F2 HIST1H1C AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17661 T17 ELM DES ____MSQAYSSsQRVssYRRtFGGAPGFPLGsPLssPVFPR
P17661 T76 ELM DES VSRtsGGAGGLGsLRAsRLGttRtPssyGAGELLDFsLADA
P17661 T77 ELM DES SRtsGGAGGLGsLRAsRLGttRtPssyGAGELLDFsLADAV
P18124 T170 Sugiyama RPL7 VNELIyKRGYGKINKKRIALtDNALIARSLGKyGIICMEDL
P18615 S131 Sugiyama NELFE RD RDBP QRsIsADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGE
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P18621 T79 Sugiyama RPL17 PFRRYNGGVGRCAQAKQWGWtQGRWPKKSAEFLLHMLKNAE
P18669 T146 Sugiyama PGAM1 PGAMA CDABP0006 MEPDHPFysNIsKDRRyADLtEDQLPsCEsLKDtIARALPF
P18669 T159 Sugiyama PGAM1 PGAMA CDABP0006 DRRyADLtEDQLPsCEsLKDtIARALPFWNEEIVPQIKEGK
P19105 S19 Sugiyama MYL12A MLCB MRLC3 RLC __MSSKRTKTKTKKRPQRAtsNVFAMFDQSQIQEFKEAFNM
P19105 T18 Sugiyama MYL12A MLCB MRLC3 RLC ___MSSKRTKTKTKKRPQRAtsNVFAMFDQSQIQEFKEAFN
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19634 T653 EPSD|PSP SLC9A1 APNH1 NHE1 KILRNNLQKTRQRLRsyNRHtLVADPyEEAWNQMLLRRQKA
P24844 S20 GPS6|SIGNOR|Sugiyama MYL9 MLC2 MRLC1 MYRL2 _MssKRAKAKtTKKRPQRAtsNVFAMFDQSQIQEFKEAFNM
P24844 T19 GPS6|SIGNOR|EPSD|Sugiyama MYL9 MLC2 MRLC1 MYRL2 __MssKRAKAKtTKKRPQRAtsNVFAMFDQSQIQEFKEAFN
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P26038 T526 Sugiyama MSN EERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHA
P26038 T558 GPS6|ELM|EPSD MSN KTANDMIHAENMRLGRDKYKtLRQIRQGNTKQRIDEFEsM_
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373 T107 Sugiyama RPL13 BBC1 OK/SW-cl.46 HKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILF
P26373 T148 Sugiyama RPL13 BBC1 OK/SW-cl.46 PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373 T151 Sugiyama RPL13 BBC1 OK/SW-cl.46 PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P26373 T24 Sugiyama RPL13 BBC1 OK/SW-cl.46 SRNGMVLKPHFHKDWQRRVAtWFNQPARKIRRRKARQAKAR
P26641 T287 Sugiyama EEF1G EF1G PRO1608 EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P27708 S1859 Sugiyama CAD RGIPGLPDGRFHLPPRIHRAsDPGLPAEEPKEKSSRKVAEP
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P30086 S52 Sugiyama PEBP1 PBP PEBP AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P30086 S54 Sugiyama PEBP1 PBP PEBP VDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPDAP
P30086 T167 Sugiyama PEBP1 PBP PEBP GKFKVAsFRKKyELRAPVAGtCyQAEWDDyVPKLyEQLsGK
P30086 T51 Sugiyama PEBP1 PBP PEBP GAAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDP
P30086 T65 Sugiyama PEBP1 PBP PEBP QVKNRPtsIsWDGLDsGKLytLVLtDPDAPsRKDPKYREWH
P30086 Y64 Sugiyama PEBP1 PBP PEBP tQVKNRPtsIsWDGLDsGKLytLVLtDPDAPsRKDPKYREW
P32119 T142 Sugiyama PRDX2 NKEFB TDPX1 EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34932 S76 Sugiyama HSPA4 APG2 HSPH2 VISNAKNTVQGFKRFHGRAFsDPFVEAEKSNLAYDIVQLPT
P35241 T564 ELM RDX KTQNDVLHAENVKAGRDKYKtLRQIRQGNtKQRIDEFEAM_
P35241 T573 ELM RDX ENVKAGRDKYKtLRQIRQGNtKQRIDEFEAM__________
P35269 T154 Sugiyama GTF2F1 RAP74 AFEAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHF
P35269 T156 Sugiyama GTF2F1 RAP74 EAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHFSI
P35611 T445 GPS6|ELM|EPSD ADD1 ADDA GDsGtCsPLRHsFQKQQREKtRWLNSGRGDEASEEGQNGss
P35611 T480 GPS6|ELM|EPSD ADD1 ADDA GQNGssPKsKTKWTKEDGHRtstsAVPNLFVPLNTNPKEVQ
P36578 S55 Sugiyama RPL4 RPL1 DIVNFVHTNLRKNNRQPyAVsELAGHQtsAEsWGtGRAVAR
P36578 T62 Sugiyama RPL4 RPL1 TNLRKNNRQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGG
P36578 T69 Sugiyama RPL4 RPL1 RQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGGGtHRsGQ
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P37837 S13 Sugiyama TALDO1 TAL TALDO TALDOR ________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646 T111 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VAFtADGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDP
P38646 T116 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646 T398 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P38646 T94 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 QAKVLENAEGARttPsVVAFtADGERLVGMPAKRQAVtNPN
P39019 Y54 Sugiyama RPS19 VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P42677 T74 Sugiyama RPS27 MPS1 VLCVGCSTVLCQPTGGKARLtEGCsFRRKQH__________
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46776 T72 Sugiyama RPL27A yFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRVNAAK
P46776 T95 Sugiyama RPL27A LDKLWtLVsEQtRVNAAKNKtGAAPIIDVVRsGyyKVLGKG
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46783 T148 Sugiyama RPS10 RRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ___
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51116 T610 Sugiyama FXR2 FMR1L2 RRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQsRQRPPLER
P53667 T508 ELM LIMK1 LIMK EKTQPEGLRSLKKPDRKKRYtVVGNPyWMAPEMINGRSYDE
P53671 T505 ELM|EPSD|PSP LIMK2 MEKATTKKRtLRKNDRKKRYtVVGNPYWMAPEMLNGKSYDE
P53999 S118 Sugiyama SUB1 PC4 RPO2TC1 PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P56817 S498 EPSD|PSP BACE1 BACE KIAA1149 CQWRCLRCLRQQHDDFADDIsLLK_________________
P57053 S37 Sugiyama H2BC12L H2BFS H2BS1 KAVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIss
P57053 S39 Sugiyama H2BC12L H2BFS H2BS1 VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P58876 S37 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
P58876 S39 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P60174 S21 Sugiyama TPI1 TPI MAPSRKFFVGGNWKMNGRKQsLGELIGtLNAAKVPADtEVV
P60174 T28 Sugiyama TPI1 TPI FVGGNWKMNGRKQsLGELIGtLNAAKVPADtEVVCAPPtAy
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 T318 Sugiyama ACTB VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P61254 T8 Sugiyama RPL26 _____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P61353 T94 Sugiyama RPL27 VyNyNHLMPtRysVDIPLDKtVVNKDVFRDPALKRKARREA
P61981 T31 Sugiyama YWHAG ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62263 S70 Sugiyama RPS14 PRO2640 KETICRVTGGMKVKADRDEssPyAAMLAAQDVAQRCKELGI
P62269 S96 Sugiyama RPS18 D6S218E QYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLKK
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280 T15 Sugiyama RPS11 ______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62316 T40 Sugiyama SNRPD2 SNRPD1 EEEEFNtGPLsVLtQsVKNNtQVLINCRNNKKLLGRVKAFD
P62424 T84 Sugiyama RPL7A SURF-3 SURF3 QRQRAILyKRLKVPPAINQFtQALDRQTAtQLLKLAHKYRP
P62701 T247 Sugiyama RPS4X CCG2 RPS4 SCAR VIGKGNKPWIsLPRGKGIRLtIAEERDKRLAAKQSSG____
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 T320 Sugiyama ACTA2 ACTSA ACTVS GIG46 VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62753 T34 Sugiyama RPS6 OK/SW-cl.2 KLIEVDDERKLRtFyEKRMAtEVAADALGEEWKGYVVRIsG
P62805 S48 Sugiyama H4C1 H4/A H4FA HIST1H4A; H4C2 H4/I H4FI HIST1H4B; H4C3 H4/G H4FG HIST1H4C; H4C4 H4/B H4FB HIST1H4D; H4C5 H4/J H4FJ HIST1H4E; H4C6 H4/C H4FC HIST1H4F; H4C8 H4/H H4FH HIST1H4H; H4C9 H4/M H4FM HIST1H4I; H4C11 H4/E H4FE HIST1H4J; H4C12 H4/D H4FD HIST1H4K; H4C13 H4/K H4FK HIST1H4L; H4C14 H4/N H4F2 H4FN HIST2H4 HIST2H4A; H4C15 H4/O H4FO HIST2H4B; H4C16 H4-16 HIST4H4 QGItKPAIRRLARRGGVKRIsGLIyEETRGVLKVFLENVIR
P62807 S37 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI KAVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIss
P62807 S39 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA
P62826 T66 Sugiyama RAN ARA24 OK/SW-cl.81 EVHPLVFHTNRGPIKFNVWDtAGQEKFGGLRDGYYIQAQCA
P62857 T28 Sugiyama RPS28 PIKLARVTKVLGRtGsQGQCtQVRVEFMDDtsRsIIRNVKG
P62899 S15 Sugiyama RPL31 ______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62899 T22 Sugiyama RPL31 APAKKGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRA
P62899 T26 Sugiyama RPL31 KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62899 Y25 Sugiyama RPL31 KKGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRA
P62906 S64 Sugiyama RPL10A NEDD6 QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62906 T9 Sugiyama RPL10A NEDD6 ____________MSSKVsRDtLyEAVREVLHGNQRKRRKFL
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917 T146 Sugiyama RPL8 LARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVISSANRAVV
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62937 T157 Sugiyama PPIA CYPA NIVEAMERFGsRNGKTSKKItIADCGQLE____________
P62942 T22 Sugiyama FKBP1A FKBP1 FKBP12 GVQVEtIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRD
P63173 T14 Sugiyama RPL38 _______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 T318 Sugiyama ACTG1 ACTG VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 T319 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P67809 S102 Sugiyama YBX1 NSEP1 YB1 EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P67809 T108 Sugiyama YBX1 NSEP1 YB1 QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P67809 T80 Sugiyama YBX1 NSEP1 YB1 LGTVKWFNVRNGyGFINRNDtKEDVFVHQtAIKKNNPRKyL
P67809 Y99 Sugiyama YBX1 NSEP1 YB1 DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 T320 Sugiyama ACTC1 ACTC VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68104 T261 Sugiyama EEF1A1 EEF1A EF1A LENG7 PTDKPLRLPLQDVyKIGGIGtVPVGRVEtGVLKPGMVVtFA
P68104 T432 EPSD|PSP|Sugiyama EEF1A1 EEF1A EF1A LENG7 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 T320 Sugiyama ACTA1 ACTA VMSGGTTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68363 T73 Sugiyama TUBA1B FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363 T82 Sugiyama TUBA1B VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
P78316 S29 Sugiyama NOP14 C4orf9 NOL14 RES4-25 ARRKASGAPAGARGGPAKANsNPFEVKVNRQKFQILGRKTR
P83731 S86 Sugiyama RPL24 EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098 S12 Sugiyama RPL19 _________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
P84098 S13 Sugiyama RPL19 ________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEIA
P84098 T29 Sugiyama RPL19 RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
P98082 S723 EPSD|PSP DAB2 DOC2 DANQLLNKINEPPKPAPRQVsLPVTKstDNAFENPFFKDsF
Q01105 S166 Sugiyama SET yFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQT
Q01105 T169 Sugiyama SET NKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQNK
Q02543 T101 Sugiyama RPL18A WLRYDsRSGtHNMYREyRDLttAGAVtQCyRDMGARHRARA
Q02543 T107 Sugiyama RPL18A RSGtHNMYREyRDLttAGAVtQCyRDMGARHRARAHsIQIM
Q02543 Y97 Sugiyama RPL18A NFGIWLRYDsRSGtHNMYREyRDLttAGAVtQCyRDMGARH
Q02878 T213 Sugiyama RPL6 TXREB1 FVIAtsTKIDISNVKIPKHLtDAyFKKKKLRKPRHQEGEIF
Q05639 T261 Sugiyama EEF1A2 EEF1AL STN PTDKPLRLPLQDVyKIGGIGtVPVGRVETGILRPGMVVTFA
Q05639 T432 Sugiyama EEF1A2 EEF1AL STN VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q06830 T143 Sugiyama PRDX1 PAGA PAGB TDPX2 EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q13247 S297 Sugiyama SRSF6 SFRS6 SRP55 RSRSPKENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsP
Q13283 S250 Sugiyama G3BP1 G3BP sssPAPADIAQtVQEDLRtFsWAsVtsKNLPPSGAVPVTGI
Q13283 T255 Sugiyama G3BP1 G3BP PADIAQtVQEDLRtFsWAsVtsKNLPPSGAVPVTGIPPHVV
Q13310 T191 Sugiyama PABPC4 APP1 PABP4 GRFKSRKEREAELGAKAKEFtNVyIKNFGEEVDDEsLKELF
Q13442 S19 Sugiyama PDAP1 HASPP28 __MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEEE
Q13442 T18 Sugiyama PDAP1 HASPP28 ___MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEE
Q13442 T93 Sugiyama PDAP1 HASPP28 KRKGVEGLIDIENPNRVAQttKKVtQLDLDGPKELSRRERE
Q13442 T97 Sugiyama PDAP1 HASPP28 VEGLIDIENPNRVAQttKKVtQLDLDGPKELSRREREEIEK
Q13464 S118 Sugiyama ROCK1 TRKVYAMKLLSKFEMIKRSDsAFFWEERDIMAFANSPWVVQ
Q13464 T219 Sugiyama ROCK1 VKPDNMLLDKSGHLKLADFGtCMKMNKEGMVRCDtAVGtPD
Q14160 S1378 Sugiyama SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL QKyFELEVRVPQAEGPPKRVsLVGADDLRKMQEEEARKLQQ
Q14247 T401 Sugiyama CTTN EMS1 RQEQEEARRKLEEQARAKtQtPPVsPAPQPtEERLPssPVy
Q14847 S99 Sugiyama LASP1 MLN50 ELQsQVRYKEEFEKNKGKGFsVVADtPELQRIKKTQDQIsN
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15306 S447 SIGNOR IRF4 MUM1 GyDLPEHISNPEDYHRSIRHssIQE________________
Q15306 S448 SIGNOR IRF4 MUM1 yDLPEHISNPEDYHRSIRHssIQE_________________
Q15417 S293 EPSD|PSP CNN3 CAAPTEPVIHNGSQGTGTNGsEIsDSDYQAEYPDEYHGEYQ
Q16555 T555 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP DPYSL2 CRMP2 ULIP2 HQsGFsLsGAQIDDNIPRRTtQRIVAPPGGRANITSLG___
Q58FF6 S34 Sugiyama HSP90AB4P IFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDIIPN
Q58FF7 S58 Sugiyama HSP90AB3P HSP90BC IFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FF8 S58 Sugiyama HSP90AB2P HSP90BB IFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q5QNW6 S37 Sugiyama H2BC18 HIST2H2BF KAVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q5QNW6 S39 Sugiyama H2BC18 HIST2H2BF VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q5VTE0 T261 Sugiyama EEF1A1P5 EEF1AL3 PTDKPLRLPLQDVyKIGGIGtVPVGRVEtGVLKPGMVVtFA
Q5VTE0 T432 Sugiyama EEF1A1P5 EEF1AL3 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q6QNY0 T16 Sugiyama BLOC1S3 BLOS3 _____MASQGRRRRPLRRPEtVVPGEAtEtDsERsAsssEE
Q71U36 T73 Sugiyama TUBA1A TUBA3 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36 T82 Sugiyama TUBA1A TUBA3 VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
Q71UM5 T74 Sugiyama RPS27L VLCVGCSTVLCQPTGGKARLtEGCsFRRKQH__________
Q86UK7 T857 Sugiyama ZNF598 REKPLSTKSKKNKKsAWQATtQQAGLDCRVCPTCQQVLAHG
Q86VM9 S601 Sugiyama ZC3H18 NHN1 SYSSRSSRHSSFSGSRSRsRsFsssPsPsPtPsPHRPsIRT
Q86VM9 S603 Sugiyama ZC3H18 NHN1 SSRSSRHSSFSGSRSRsRsFsssPsPsPtPsPHRPsIRTKG
Q86VM9 S618 Sugiyama ZC3H18 NHN1 RsRsFsssPsPsPtPsPHRPsIRTKGEPAPPPGKAGEKSVK
Q8NFD5 S1744 Sugiyama ARID1B BAF250B DAN15 KIAA1235 OSA2 ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8TD47 T247 Sugiyama RPS4Y2 RPS4Y2P VIGNGNKPWISLPRGKGIRLtIAEERDKRLAAKQSSG____
Q8WWI1 T932 Sugiyama LMO7 FBX20 FBXO20 KIAA0858 VtPRPFGsQtRGISsLPRsYtMDDAWKYNGDVEDIKRtPNN
Q92673 S2206 GPS6|EPSD|PSP SORL1 C11orf32 FSSGDDLGEDDEDAPMITGFsDDVPMVIA____________
Q92688 S104 Sugiyama ANP32B APRIL PHAPI2 AEKLPNLTHLNLsGNKLKDIstLEPLKKLECLKsLDLFNCE
Q93079 S37 Sugiyama H2BC9 H2BFJ HIST1H2BH KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q93079 S39 Sugiyama H2BC9 H2BFJ HIST1H2BH VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q96A00 T38 SIGNOR|EPSD|PSP PPP1R14A CPI17 PPP1INL SRARGPGGsPGGLQKRHARVtVKYDRRELQRRLDVEKWIDG
Q96C90 T57 EPSD|PSP PPP1R14B PLCB3N PNG AGEGPGGADDEGPVRRQGKVtVKYDRKELRKRLNLEEWILE
Q99613 T157 Sugiyama EIF3C EIF3S8 ALSTLRQKIRKyNRDFEsHItSyKQNPEQsADEDAEKNEED
Q99733 S22 Sugiyama NAP1L4 NAP2 ADHsFsDGVPsDsVEAAKNAsNtEKLtDQVMQNPRVLAALQ
Q99733 T28 Sugiyama NAP1L4 NAP2 DGVPsDsVEAAKNAsNtEKLtDQVMQNPRVLAALQERLDNV
Q99848 T261 Sugiyama EBNA1BP2 EBP2 RRYKNQKFGFGGKKKGSKWNtREsyDDVssFRAKTAHGRGL
Q99877 S37 Sugiyama H2BC15 H2BFD HIST1H2BN KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99877 S39 Sugiyama H2BC15 H2BFD HIST1H2BN VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99879 S37 Sugiyama H2BC14 H2BFE HIST1H2BM KAINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99879 S39 Sugiyama H2BC14 H2BFE HIST1H2BM INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99880 S37 Sugiyama H2BC13 H2BFC HIST1H2BL KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99880 S39 Sugiyama H2BC13 H2BFC HIST1H2BL VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99962 T14 SIGNOR|EPSD|PSP SH3GL2 CNSA2 SH3D2A _______MSVAGLKKQFHKAtQKVSEKVGGAEGTKLDDDFK
Q9BQE3 T73 Sugiyama TUBA1C TUBA6 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3 T82 Sugiyama TUBA1C TUBA6 VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
Q9BUJ2 T113 Sugiyama HNRNPUL1 E1BAP5 HNRPUL1 SGPDGHYAMDNITRQNQFyDtQVIKQENESGyERRPLEMEQ
Q9BZL4 T560 GPS6 PPP1R12C LENG3 MBS85 EESESQRKARSRLMRQSRRstQGVtLTDLKEAEKAAGKAPE
Q9NQ39 T159 Sugiyama RPS10P5 RPS10L RRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ___
Q9UNX3 T8 Sugiyama RPL26L1 RPL26P1 _____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Q9UQ35 S1099 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sHsEsPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRG
Q9UQ35 S2692 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9UQ80 T377 Sugiyama PA2G4 EBP1 LLQssAsRKtQKKKKKKAsKtAENAtsGEtLEENEAGD___
Q9Y2B0 S116 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 IDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKFA
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2T7 S137 Sugiyama YBX2 CSDA3 MSY2 EDVFVHQtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEA
Q9Y2T7 T115 Sugiyama YBX2 CSDA3 MSY2 LGTVKWFNVRNGyGFINRNDtKEDVFVHQtAIKRNNPRKFL
Q9Y2T7 T143 Sugiyama YBX2 CSDA3 MSY2 QtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEATNVTGP
Q9Y3U8 S91 Sugiyama RPL36 KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 6.801571e-09 8.167 0 0
Axon guidance R-HSA-422475 1.577473e-07 6.802 1 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.625291e-07 6.581 0 0
Apoptotic execution phase R-HSA-75153 2.869352e-07 6.542 0 0
Nervous system development R-HSA-9675108 2.259025e-07 6.646 1 0
Signal Transduction R-HSA-162582 2.802668e-06 5.552 1 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 3.077515e-06 5.512 0 0
Cell Cycle R-HSA-1640170 4.269040e-06 5.370 0 0
Semaphorin interactions R-HSA-373755 6.603836e-06 5.180 1 0
Cellular Senescence R-HSA-2559583 2.048119e-05 4.689 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.376614e-05 4.472 0 0
Developmental Biology R-HSA-1266738 3.840235e-05 4.416 1 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 5.069608e-05 4.295 0 0
FOXO-mediated transcription R-HSA-9614085 5.896814e-05 4.229 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 6.085138e-05 4.216 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 7.296640e-05 4.137 0 0
Activation of RAC1 R-HSA-428540 7.403579e-05 4.131 0 0
RNA Polymerase II Transcription R-HSA-73857 7.866579e-05 4.104 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.035655e-04 3.985 1 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.703694e-04 3.769 1 1
G alpha (12/13) signalling events R-HSA-416482 1.959687e-04 3.708 1 1
Cell Cycle Checkpoints R-HSA-69620 2.309852e-04 3.636 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.598191e-04 3.585 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 2.581291e-04 3.588 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.703517e-04 3.568 0 0
Signaling by Interleukins R-HSA-449147 3.709608e-04 3.431 0 0
PKMTs methylate histone lysines R-HSA-3214841 4.100344e-04 3.387 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 4.435593e-04 3.353 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 4.442713e-04 3.352 0 0
Gene expression (Transcription) R-HSA-74160 4.488322e-04 3.348 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 5.037061e-04 3.298 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 5.284596e-04 3.277 0 0
Signaling by ROBO receptors R-HSA-376176 6.530775e-04 3.185 0 0
Generic Transcription Pathway R-HSA-212436 7.745316e-04 3.111 0 0
Germ layer formation at gastrulation R-HSA-9754189 8.841284e-04 3.053 0 0
RET signaling R-HSA-8853659 8.894297e-04 3.051 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.028344e-03 2.988 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 9.949394e-04 3.002 1 1
Transcriptional Regulation by TP53 R-HSA-3700989 9.646201e-04 3.016 0 0
Death Receptor Signaling R-HSA-73887 1.078887e-03 2.967 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.439741e-03 2.842 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.439741e-03 2.842 0 0
Cell Cycle, Mitotic R-HSA-69278 1.607380e-03 2.794 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.698606e-03 2.770 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 1.698606e-03 2.770 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.766706e-03 2.753 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.890419e-03 2.723 0 0
Meiotic synapsis R-HSA-1221632 2.129812e-03 2.672 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.974816e-03 2.704 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.114302e-03 2.675 0 0
Signaling by VEGF R-HSA-194138 2.174700e-03 2.663 1 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.281023e-03 2.642 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.322306e-03 2.634 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 2.698437e-03 2.569 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 2.698437e-03 2.569 0 0
Dopamine receptors R-HSA-390651 2.698437e-03 2.569 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.692863e-03 2.570 0 0
Neurodegenerative Diseases R-HSA-8863678 2.692863e-03 2.570 0 0
EPH-Ephrin signaling R-HSA-2682334 2.787799e-03 2.555 1 0
NRAGE signals death through JNK R-HSA-193648 2.918434e-03 2.535 0 0
MAPK family signaling cascades R-HSA-5683057 3.173624e-03 2.498 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 3.227171e-03 2.491 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.834543e-03 2.416 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.834543e-03 2.416 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.834543e-03 2.416 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.834543e-03 2.416 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.834543e-03 2.416 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.144983e-03 2.382 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 4.060416e-03 2.391 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 3.983196e-03 2.400 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.942055e-03 2.404 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 4.011293e-03 2.397 0 0
Programmed Cell Death R-HSA-5357801 3.826509e-03 2.417 0 0
Apoptosis R-HSA-109581 4.103556e-03 2.387 0 0
Regulation of TP53 Activity R-HSA-5633007 3.680703e-03 2.434 0 0
Polo-like kinase mediated events R-HSA-156711 4.246476e-03 2.372 0 0
Ephrin signaling R-HSA-3928664 4.246476e-03 2.372 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.264813e-03 2.370 0 0
mRNA Splicing - Major Pathway R-HSA-72163 4.571561e-03 2.340 0 0
Mitotic Prometaphase R-HSA-68877 4.354580e-03 2.361 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.367066e-03 2.360 0 0
Intracellular signaling by second messengers R-HSA-9006925 4.905208e-03 2.309 0 0
Rap1 signalling R-HSA-392517 5.065761e-03 2.295 0 0
Interleukin-12 signaling R-HSA-9020591 5.585346e-03 2.253 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.985530e-03 2.223 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 6.151782e-03 2.211 0 0
mRNA 3'-end processing R-HSA-72187 6.632172e-03 2.178 0 0
mRNA Splicing R-HSA-72172 7.602850e-03 2.119 0 0
Formation of axial mesoderm R-HSA-9796292 7.847449e-03 2.105 0 0
Diseases of mitotic cell cycle R-HSA-9675126 8.255127e-03 2.083 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 7.847449e-03 2.105 0 0
Reproduction R-HSA-1474165 7.672508e-03 2.115 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 8.374955e-03 2.077 0 0
TNF signaling R-HSA-75893 9.535132e-03 2.021 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.005296e-02 1.998 0 0
Netrin-1 signaling R-HSA-373752 1.025118e-02 1.989 0 0
Meiosis R-HSA-1500620 1.087244e-02 1.964 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.088617e-02 1.963 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.238169e-02 1.907 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.244198e-02 1.905 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.257424e-02 1.901 0 0
Mitotic Anaphase R-HSA-68882 1.258552e-02 1.900 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.309621e-02 1.883 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.437987e-02 1.842 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.441916e-02 1.841 0 0
Recycling pathway of L1 R-HSA-437239 1.355877e-02 1.868 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.353955e-02 1.868 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.353955e-02 1.868 0 0
Interleukin-12 family signaling R-HSA-447115 1.328795e-02 1.877 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.445425e-02 1.840 0 0
Co-stimulation by CD28 R-HSA-389356 1.481393e-02 1.829 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.524365e-02 1.817 1 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.553099e-02 1.809 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 1.589514e-02 1.799 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.641483e-02 1.785 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 1.770670e-02 1.752 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.846506e-02 1.734 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.853136e-02 1.732 0 0
Specification of primordial germ cells R-HSA-9827857 1.849301e-02 1.733 0 0
Developmental Cell Lineages R-HSA-9734767 2.031097e-02 1.692 0 0
Separation of Sister Chromatids R-HSA-2467813 2.058657e-02 1.686 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.133952e-02 1.671 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.133952e-02 1.671 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.157289e-02 1.666 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 2.168558e-02 1.664 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.178721e-02 1.662 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.295710e-02 1.639 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 2.405804e-02 1.619 0 0
Chromatin modifying enzymes R-HSA-3247509 2.454637e-02 1.610 0 0
FLT3 Signaling R-HSA-9607240 2.318186e-02 1.635 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.277447e-02 1.643 0 0
Signaling by FGFR1 in disease R-HSA-5655302 2.528960e-02 1.597 0 0
G2/M Transition R-HSA-69275 2.659111e-02 1.575 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.779889e-02 1.556 0 0
Formation of definitive endoderm R-HSA-9823730 2.779889e-02 1.556 0 0
TNFR1-mediated ceramide production R-HSA-5626978 3.066181e-02 1.513 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 3.066181e-02 1.513 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 3.066181e-02 1.513 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 3.066181e-02 1.513 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 3.135507e-02 1.504 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 3.044073e-02 1.517 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 3.066181e-02 1.513 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 3.135507e-02 1.504 0 0
M Phase R-HSA-68886 2.981353e-02 1.526 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 3.135507e-02 1.504 0 0
MTF1 activates gene expression R-HSA-5660489 3.066181e-02 1.513 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.867450e-02 1.543 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 3.013077e-02 1.521 0 0
Amine ligand-binding receptors R-HSA-375280 3.236596e-02 1.490 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.236596e-02 1.490 1 1
G-protein beta:gamma signalling R-HSA-397795 3.344833e-02 1.476 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.344833e-02 1.476 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 3.369083e-02 1.472 0 0
Diseases of programmed cell death R-HSA-9645723 3.446362e-02 1.463 0 0
G2/M DNA damage checkpoint R-HSA-69473 3.494385e-02 1.457 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 3.683656e-02 1.434 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 4.052996e-02 1.392 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 3.683656e-02 1.434 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 4.052996e-02 1.392 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 4.052996e-02 1.392 0 0
Chromatin organization R-HSA-4839726 3.989937e-02 1.399 0 0
Signaling by TGFBR3 R-HSA-9839373 3.773333e-02 1.423 0 0
Muscle contraction R-HSA-397014 3.773650e-02 1.423 0 0
NrCAM interactions R-HSA-447038 4.052996e-02 1.392 0 0
L1CAM interactions R-HSA-373760 3.681694e-02 1.434 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.900844e-02 1.409 0 0
S Phase R-HSA-69242 4.161254e-02 1.381 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 4.277472e-02 1.369 0 0
CD28 dependent Vav1 pathway R-HSA-389359 4.277472e-02 1.369 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 4.354874e-02 1.361 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 4.363752e-02 1.360 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 4.414425e-02 1.355 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 4.457299e-02 1.351 0 0
SARS-CoV-1-host interactions R-HSA-9692914 4.468506e-02 1.350 0 0
RAF/MAP kinase cascade R-HSA-5673001 4.487467e-02 1.348 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 5.141564e-02 1.289 0 0
Signaling by MAPK mutants R-HSA-9652817 5.141564e-02 1.289 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 5.027828e-02 1.299 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 4.847905e-02 1.314 0 0
ESR-mediated signaling R-HSA-8939211 4.758718e-02 1.323 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 5.141564e-02 1.289 0 0
HDMs demethylate histones R-HSA-3214842 5.350099e-02 1.272 0 0
TGFBR3 expression R-HSA-9839394 5.350099e-02 1.272 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 4.905449e-02 1.309 0 0
Calmodulin induced events R-HSA-111933 4.727986e-02 1.325 0 0
CaM pathway R-HSA-111997 4.727986e-02 1.325 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 5.141564e-02 1.289 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 4.678902e-02 1.330 0 0
Signaling by ALK in cancer R-HSA-9700206 4.678902e-02 1.330 0 0
HDL assembly R-HSA-8963896 4.916045e-02 1.308 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 5.416329e-02 1.266 0 0
Cell junction organization R-HSA-446728 5.461880e-02 1.263 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 5.529360e-02 1.257 0 0
Cell-extracellular matrix interactions R-HSA-446353 5.598270e-02 1.252 0 0
Formation of the anterior neural plate R-HSA-9823739 5.598270e-02 1.252 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 5.709626e-02 1.243 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 5.830719e-02 1.234 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 5.830719e-02 1.234 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 5.871134e-02 1.231 0 0
TRP channels R-HSA-3295583 5.871134e-02 1.231 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 5.966580e-02 1.224 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 6.026216e-02 1.220 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 6.080929e-02 1.216 0 0
Smooth Muscle Contraction R-HSA-445355 6.080929e-02 1.216 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.321004e-02 1.199 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 6.321004e-02 1.199 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 7.581197e-02 1.120 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 7.581197e-02 1.120 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 6.418207e-02 1.193 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 6.990988e-02 1.155 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 6.404324e-02 1.194 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 7.088455e-02 1.149 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 7.088455e-02 1.149 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 6.418207e-02 1.193 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 6.339050e-02 1.198 0 0
Generation of second messenger molecules R-HSA-202433 6.404324e-02 1.194 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 7.088455e-02 1.149 0 0
Ion homeostasis R-HSA-5578775 7.278835e-02 1.138 0 0
Cellular responses to stimuli R-HSA-8953897 6.322263e-02 1.199 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 6.321004e-02 1.199 0 0
Glycolysis R-HSA-70171 6.815488e-02 1.167 0 0
MECP2 regulates transcription factors R-HSA-9022707 7.581197e-02 1.120 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 7.581197e-02 1.120 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 6.648396e-02 1.177 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.329560e-02 1.199 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 7.278835e-02 1.138 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 7.589083e-02 1.120 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 7.589083e-02 1.120 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 7.589083e-02 1.120 0 0
DARPP-32 events R-HSA-180024 7.589083e-02 1.120 0 0
Glucose metabolism R-HSA-70326 7.731676e-02 1.112 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 7.755594e-02 1.110 0 0
Ca-dependent events R-HSA-111996 7.853612e-02 1.105 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 7.893475e-02 1.103 0 0
Signaling by Hippo R-HSA-2028269 7.893475e-02 1.103 0 0
Uptake and function of anthrax toxins R-HSA-5210891 7.893475e-02 1.103 0 0
Homology Directed Repair R-HSA-5693538 8.031279e-02 1.095 0 0
Response of endothelial cells to shear stress R-HSA-9860931 8.061027e-02 1.094 0 0
Signaling by FGFR in disease R-HSA-1226099 8.147170e-02 1.089 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 8.147174e-02 1.089 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 8.212036e-02 1.086 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 8.634235e-02 1.064 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 8.634235e-02 1.064 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 8.634235e-02 1.064 0 0
Activation of RAS in B cells R-HSA-1169092 8.912735e-02 1.050 0 0
FGFR1b ligand binding and activation R-HSA-190370 8.912735e-02 1.050 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.030688e-01 0.987 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 9.615248e-02 1.017 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.003478e-01 0.998 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.003478e-01 0.998 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.003478e-01 0.998 0 0
Centrosome maturation R-HSA-380287 8.549959e-02 1.068 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.825078e-02 1.008 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.022467e-01 0.990 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 8.602079e-02 1.065 0 0
G0 and Early G1 R-HSA-1538133 9.530417e-02 1.021 0 0
Signaling by RAS mutants R-HSA-6802949 1.003478e-01 0.998 0 0
Adrenoceptors R-HSA-390696 8.912735e-02 1.050 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 8.912735e-02 1.050 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.022467e-01 0.990 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.552863e-02 1.020 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 1.030688e-01 0.987 0 0
Kinesins R-HSA-983189 9.070682e-02 1.042 0 0
Specification of the neural plate border R-HSA-9834899 9.615248e-02 1.017 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 1.030688e-01 0.987 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 8.736309e-02 1.059 0 0
PKA activation R-HSA-163615 8.736309e-02 1.059 0 0
PKA activation in glucagon signalling R-HSA-164378 8.736309e-02 1.059 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.030688e-01 0.987 0 0
PLC beta mediated events R-HSA-112043 9.552863e-02 1.020 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.003478e-01 0.998 0 0
DAG and IP3 signaling R-HSA-1489509 9.463494e-02 1.024 0 0
Sensory processing of sound R-HSA-9659379 1.027214e-01 0.988 0 0
Signaling by SCF-KIT R-HSA-1433557 8.372661e-02 1.077 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 8.912735e-02 1.050 0 0
Cardiogenesis R-HSA-9733709 1.022467e-01 0.990 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 8.715805e-02 1.060 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.052852e-01 0.978 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.052852e-01 0.978 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.052852e-01 0.978 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.052852e-01 0.978 0 0
Signaling by NODAL R-HSA-1181150 1.052852e-01 0.978 0 0
Protein hydroxylation R-HSA-9629569 1.052852e-01 0.978 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.055740e-01 0.976 0 0
Signaling by PTK6 R-HSA-8848021 1.055740e-01 0.976 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 1.266800e-01 0.897 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 1.266800e-01 0.897 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 1.266800e-01 0.897 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 1.266800e-01 0.897 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 1.266800e-01 0.897 0 0
Intestinal infectious diseases R-HSA-8942233 1.266800e-01 0.897 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 1.266800e-01 0.897 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.652391e-01 0.782 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.652391e-01 0.782 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 1.652391e-01 0.782 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.652391e-01 0.782 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.652391e-01 0.782 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 1.652391e-01 0.782 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.652391e-01 0.782 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.652391e-01 0.782 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.652391e-01 0.782 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.652391e-01 0.782 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 1.652391e-01 0.782 0 0
Potassium transport channels R-HSA-1296067 1.652391e-01 0.782 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.652391e-01 0.782 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.652391e-01 0.782 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 1.652391e-01 0.782 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.652391e-01 0.782 0 0
Invadopodia formation R-HSA-8941237 2.020979e-01 0.694 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 2.020979e-01 0.694 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 2.020979e-01 0.694 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 2.373314e-01 0.625 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.373314e-01 0.625 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.373314e-01 0.625 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.175554e-01 0.930 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 1.175554e-01 0.930 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 1.325119e-01 0.878 0 0
IRS activation R-HSA-74713 2.710111e-01 0.567 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.710111e-01 0.567 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 2.710111e-01 0.567 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.710111e-01 0.567 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 2.710111e-01 0.567 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 2.710111e-01 0.567 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.710111e-01 0.567 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 1.478687e-01 0.830 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 1.478687e-01 0.830 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.478687e-01 0.830 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.635616e-01 0.786 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.635616e-01 0.786 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.635616e-01 0.786 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.635616e-01 0.786 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.635616e-01 0.786 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 3.032055e-01 0.518 0 0
PKB-mediated events R-HSA-109703 3.032055e-01 0.518 0 0
PDE3B signalling R-HSA-165160 3.032055e-01 0.518 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 3.032055e-01 0.518 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 3.032055e-01 0.518 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 3.032055e-01 0.518 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 3.032055e-01 0.518 0 0
Signaling by RNF43 mutants R-HSA-5340588 3.032055e-01 0.518 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 1.795309e-01 0.746 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.795309e-01 0.746 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 1.147431e-01 0.940 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.957219e-01 0.708 0 0
STAT5 Activation R-HSA-9645135 3.339799e-01 0.476 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.339799e-01 0.476 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.120840e-01 0.673 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.120840e-01 0.673 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.120840e-01 0.673 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.285705e-01 0.641 0 0
Phosphorylation of the APC/C R-HSA-176412 2.285705e-01 0.641 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.285705e-01 0.641 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 3.633969e-01 0.440 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.633969e-01 0.440 0 0
Netrin mediated repulsion signals R-HSA-418886 3.633969e-01 0.440 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 3.633969e-01 0.440 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.633969e-01 0.440 0 0
TRIF-mediated programmed cell death R-HSA-2562578 3.633969e-01 0.440 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 3.633969e-01 0.440 0 0
SOS-mediated signalling R-HSA-112412 3.633969e-01 0.440 0 0
Disinhibition of SNARE formation R-HSA-114516 3.633969e-01 0.440 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.633969e-01 0.440 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 1.168003e-01 0.933 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 1.662543e-01 0.779 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 2.451387e-01 0.611 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.401932e-01 0.853 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.884777e-01 0.725 1 1
Packaging Of Telomere Ends R-HSA-171306 1.884777e-01 0.725 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.617492e-01 0.582 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 2.617492e-01 0.582 0 0
Type I hemidesmosome assembly R-HSA-446107 3.915163e-01 0.407 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 3.915163e-01 0.407 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 3.915163e-01 0.407 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.915163e-01 0.407 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.915163e-01 0.407 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.783662e-01 0.555 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 2.949567e-01 0.530 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.949567e-01 0.530 0 0
CASP8 activity is inhibited R-HSA-5218900 4.183954e-01 0.378 0 0
ALK mutants bind TKIs R-HSA-9700645 4.183954e-01 0.378 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.448638e-01 0.839 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.216208e-01 0.915 0 0
Translation initiation complex formation R-HSA-72649 1.518236e-01 0.819 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.918060e-01 0.717 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.661498e-01 0.780 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.588095e-01 0.587 0 0
Striated Muscle Contraction R-HSA-390522 2.708877e-01 0.567 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.708877e-01 0.567 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.290424e-01 0.640 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 3.442825e-01 0.463 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.442825e-01 0.463 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.442825e-01 0.463 0 0
RAF activation R-HSA-5673000 2.830256e-01 0.548 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.830256e-01 0.548 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 3.604930e-01 0.443 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.604930e-01 0.443 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.200410e-01 0.657 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.200410e-01 0.657 0 0
PRC2 methylates histones and DNA R-HSA-212300 3.074226e-01 0.512 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.760979e-01 0.754 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.765523e-01 0.424 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.924420e-01 0.406 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.066215e-01 0.685 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 3.441187e-01 0.463 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 4.081458e-01 0.389 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 3.563274e-01 0.448 0 0
Attenuation phase R-HSA-3371568 3.563274e-01 0.448 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 3.563274e-01 0.448 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 3.685051e-01 0.434 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.762752e-01 0.559 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 2.993208e-01 0.524 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 2.936922e-01 0.532 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 3.007317e-01 0.522 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 4.167009e-01 0.380 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 3.384477e-01 0.471 0 0
Viral mRNA Translation R-HSA-192823 4.098604e-01 0.387 0 0
Signaling by FGFR2 R-HSA-5654738 3.658585e-01 0.437 0 0
HIV Transcription Elongation R-HSA-167169 3.563274e-01 0.448 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 1.652711e-01 0.782 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 1.652711e-01 0.782 0 0
Signaling by FGFR4 R-HSA-5654743 2.009340e-01 0.697 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 3.196542e-01 0.495 0 0
EGFR downregulation R-HSA-182971 2.348935e-01 0.629 0 0
Signaling by FGFR R-HSA-190236 3.701340e-01 0.432 0 0
Telomere Extension By Telomerase R-HSA-171319 1.998622e-01 0.699 0 0
Chromosome Maintenance R-HSA-73886 2.686412e-01 0.571 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.915957e-01 0.535 0 0
Signaling by FGFR3 R-HSA-5654741 2.195610e-01 0.658 0 0
Telomere Maintenance R-HSA-157579 3.621945e-01 0.441 0 0
Signaling by EGFR R-HSA-177929 3.279565e-01 0.484 0 0
Signaling by FGFR1 R-HSA-5654736 1.661498e-01 0.780 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.570239e-01 0.804 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.563274e-01 0.448 0 0
Estrogen-dependent gene expression R-HSA-9018519 3.874348e-01 0.412 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.884777e-01 0.725 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 2.949567e-01 0.530 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.828137e-01 0.738 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 3.114907e-01 0.507 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 3.604930e-01 0.443 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 4.081458e-01 0.389 0 0
Signaling by ERBB2 R-HSA-1227986 1.962920e-01 0.707 0 0
Frs2-mediated activation R-HSA-170968 1.795309e-01 0.746 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 3.196542e-01 0.495 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.279565e-01 0.484 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.175554e-01 0.930 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 2.230874e-01 0.652 0 0
MAP2K and MAPK activation R-HSA-5674135 1.828137e-01 0.738 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.441187e-01 0.463 0 0
Peptide chain elongation R-HSA-156902 2.762752e-01 0.559 0 0
HATs acetylate histones R-HSA-3214847 3.780799e-01 0.422 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 3.384477e-01 0.471 0 0
DNA Double Strand Break Response R-HSA-5693606 1.272229e-01 0.895 0 0
Myogenesis R-HSA-525793 1.772690e-01 0.751 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.168003e-01 0.933 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.468062e-01 0.608 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 1.635616e-01 0.786 0 0
Telomere C-strand synthesis initiation R-HSA-174430 2.120840e-01 0.673 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.633969e-01 0.440 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 3.915163e-01 0.407 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 4.183954e-01 0.378 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 3.924420e-01 0.406 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.869837e-01 0.542 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.869837e-01 0.542 0 0
Epigenetic regulation of gene expression R-HSA-212165 3.825687e-01 0.417 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.728111e-01 0.564 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.728111e-01 0.564 0 0
Prolonged ERK activation events R-HSA-169893 2.285705e-01 0.641 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.783662e-01 0.555 0 0
Neurexins and neuroligins R-HSA-6794361 1.380457e-01 0.860 0 0
Formation of the posterior neural plate R-HSA-9832991 1.325119e-01 0.878 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.635616e-01 0.786 0 0
FGFR1c ligand binding and activation R-HSA-190373 1.795309e-01 0.746 0 0
mRNA Editing: C to U Conversion R-HSA-72200 3.633969e-01 0.440 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 3.633969e-01 0.440 0 0
Tight junction interactions R-HSA-420029 1.662543e-01 0.779 0 0
Calcineurin activates NFAT R-HSA-2025928 4.183954e-01 0.378 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.828137e-01 0.738 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.329477e-01 0.876 0 0
IRS-mediated signalling R-HSA-112399 1.735066e-01 0.761 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 3.279409e-01 0.484 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.797461e-01 0.745 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 4.081458e-01 0.389 0 0
Aggrephagy R-HSA-9646399 3.563274e-01 0.448 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 3.043070e-01 0.517 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.007317e-01 0.522 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.484949e-01 0.605 0 0
Cyclin D associated events in G1 R-HSA-69231 2.101886e-01 0.677 0 0
G1 Phase R-HSA-69236 2.101886e-01 0.677 0 0
Mitotic Prophase R-HSA-68875 2.623349e-01 0.581 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 1.094144e-01 0.961 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.230874e-01 0.652 0 0
Signaling by WNT in cancer R-HSA-4791275 2.468062e-01 0.608 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.529565e-01 0.597 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.708877e-01 0.567 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 2.373314e-01 0.625 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.325119e-01 0.878 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.710111e-01 0.567 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 2.120840e-01 0.673 0 0
Eukaryotic Translation Termination R-HSA-72764 3.463478e-01 0.460 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 1.772690e-01 0.751 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.588095e-01 0.587 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 3.685051e-01 0.434 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.147431e-01 0.940 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 3.339799e-01 0.476 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 2.451387e-01 0.611 0 0
FGFR1 ligand binding and activation R-HSA-190242 2.783662e-01 0.555 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.114907e-01 0.507 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.725944e-01 0.429 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.884777e-01 0.725 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.949567e-01 0.530 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 4.183954e-01 0.378 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.588095e-01 0.587 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.725944e-01 0.429 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.075682e-01 0.683 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.129552e-01 0.672 0 0
G alpha (q) signalling events R-HSA-416476 4.071844e-01 0.390 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.735066e-01 0.761 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.697292e-01 0.770 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 3.987891e-01 0.399 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 3.998513e-01 0.398 0 0
Gastrulation R-HSA-9758941 2.272526e-01 0.643 0 0
Regulated Necrosis R-HSA-5218859 2.613726e-01 0.583 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.480224e-01 0.830 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.652391e-01 0.782 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.373314e-01 0.625 0 0
Ionotropic activity of kainate receptors R-HSA-451306 1.325119e-01 0.878 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.710111e-01 0.567 0 0
Formation of the Editosome R-HSA-75094 3.032055e-01 0.518 0 0
Synthesis of PS R-HSA-1483101 3.032055e-01 0.518 0 0
Phosphorylation of Emi1 R-HSA-176417 3.032055e-01 0.518 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.795309e-01 0.746 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.795309e-01 0.746 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 3.633969e-01 0.440 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.168003e-01 0.933 0 0
Regulation by c-FLIP R-HSA-3371378 3.915163e-01 0.407 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 1.998622e-01 0.699 0 0
PI3K Cascade R-HSA-109704 1.248521e-01 0.904 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.114046e-01 0.675 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 4.183954e-01 0.378 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.183954e-01 0.378 0 0
Signalling to ERKs R-HSA-187687 2.952086e-01 0.530 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.244878e-01 0.489 0 0
GPCR downstream signalling R-HSA-388396 2.121643e-01 0.673 1 0
Signaling by Nuclear Receptors R-HSA-9006931 2.860233e-01 0.544 0 0
Insulin receptor signalling cascade R-HSA-74751 2.281467e-01 0.642 0 0
Signaling by TGFB family members R-HSA-9006936 4.125242e-01 0.385 0 0
Integration of energy metabolism R-HSA-163685 3.874348e-01 0.412 0 0
IGF1R signaling cascade R-HSA-2428924 1.107943e-01 0.955 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 1.554520e-01 0.808 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.167807e-01 0.933 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.588095e-01 0.587 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.317859e-01 0.880 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 3.633969e-01 0.440 0 0
Eukaryotic Translation Elongation R-HSA-156842 3.148823e-01 0.502 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.537619e-01 0.451 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.915163e-01 0.407 0 0
Long-term potentiation R-HSA-9620244 4.081458e-01 0.389 0 0
Opioid Signalling R-HSA-111885 1.534387e-01 0.814 0 0
FLT3 signaling in disease R-HSA-9682385 1.321975e-01 0.879 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 1.161439e-01 0.935 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.175554e-01 0.930 0 0
G2/M Checkpoints R-HSA-69481 1.971253e-01 0.705 0 0
Signaling by WNT R-HSA-195721 3.656676e-01 0.437 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.828137e-01 0.738 0 0
Ca2+ pathway R-HSA-4086398 3.043070e-01 0.517 0 0
Signaling by LTK R-HSA-9842663 1.635616e-01 0.786 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.633969e-01 0.440 0 0
Interleukin-1 processing R-HSA-448706 4.183954e-01 0.378 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 4.183954e-01 0.378 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.183954e-01 0.378 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.588095e-01 0.587 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 4.019222e-01 0.396 0 0
Post NMDA receptor activation events R-HSA-438064 2.686873e-01 0.571 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.635616e-01 0.786 0 0
Regulation of BACH1 activity R-HSA-9708530 2.285705e-01 0.641 0 0
Platelet calcium homeostasis R-HSA-418360 2.114046e-01 0.675 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 2.200410e-01 0.657 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.801050e-01 0.744 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.401932e-01 0.853 0 0
Ub-specific processing proteases R-HSA-5689880 2.545608e-01 0.594 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.621945e-01 0.441 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.647817e-01 0.783 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.647817e-01 0.783 0 0
Cell-cell junction organization R-HSA-421270 1.712718e-01 0.766 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.266800e-01 0.897 0 0
DSCAM interactions R-HSA-376172 1.652391e-01 0.782 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 2.020979e-01 0.694 0 0
NADE modulates death signalling R-HSA-205025 2.373314e-01 0.625 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 3.032055e-01 0.518 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.032055e-01 0.518 0 0
Abacavir transmembrane transport R-HSA-2161517 3.339799e-01 0.476 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.168003e-01 0.933 0 0
Disorders of Developmental Biology R-HSA-9675151 2.451387e-01 0.611 0 0
Phase 2 - plateau phase R-HSA-5576893 2.451387e-01 0.611 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 3.915163e-01 0.407 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 3.915163e-01 0.407 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 3.915163e-01 0.407 0 0
Dimerization of procaspase-8 R-HSA-69416 3.915163e-01 0.407 0 0
ARMS-mediated activation R-HSA-170984 4.183954e-01 0.378 0 0
Regulation of signaling by NODAL R-HSA-1433617 4.183954e-01 0.378 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.809860e-01 0.742 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 3.924420e-01 0.406 0 0
Maturation of spike protein R-HSA-9694548 3.685051e-01 0.434 0 0
Adherens junctions interactions R-HSA-418990 2.827433e-01 0.549 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.214846e-01 0.915 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 4.235300e-01 0.373 0 0
Cell-Cell communication R-HSA-1500931 1.320776e-01 0.879 0 0
G1/S Transition R-HSA-69206 1.867282e-01 0.729 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.915163e-01 0.407 0 0
Cellular responses to stress R-HSA-2262752 1.596026e-01 0.797 0 0
G-protein mediated events R-HSA-112040 1.272229e-01 0.895 0 0
Pyroptosis R-HSA-5620971 1.998622e-01 0.699 0 0
Histamine receptors R-HSA-390650 2.020979e-01 0.694 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.339799e-01 0.476 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.345597e-01 0.871 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.120840e-01 0.673 0 0
Apoptotic factor-mediated response R-HSA-111471 2.783662e-01 0.555 0 0
Interleukin-37 signaling R-HSA-9008059 2.230874e-01 0.652 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.588095e-01 0.587 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.588095e-01 0.587 0 0
Selenocysteine synthesis R-HSA-2408557 3.939772e-01 0.405 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 3.568364e-01 0.448 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.729609e-01 0.762 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.451387e-01 0.611 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.580526e-01 0.588 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.580526e-01 0.588 0 0
Signaling by GPCR R-HSA-372790 3.134089e-01 0.504 1 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.508337e-01 0.822 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.563274e-01 0.448 0 0
Deubiquitination R-HSA-5688426 3.624191e-01 0.441 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 2.020979e-01 0.694 0 0
Estrogen biosynthesis R-HSA-193144 1.635616e-01 0.786 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.339799e-01 0.476 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.633969e-01 0.440 0 0
Regulation of PTEN localization R-HSA-8948747 3.633969e-01 0.440 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 3.915163e-01 0.407 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 4.183954e-01 0.378 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.442825e-01 0.463 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 3.765523e-01 0.424 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 3.927256e-01 0.406 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 4.177889e-01 0.379 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 3.785993e-01 0.422 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.447558e-01 0.839 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 3.685051e-01 0.434 0 0
mRNA Editing R-HSA-75072 4.183954e-01 0.378 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 4.183954e-01 0.378 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.279409e-01 0.484 0 0
Effects of PIP2 hydrolysis R-HSA-114508 2.708877e-01 0.567 0 0
Cleavage of the damaged purine R-HSA-110331 3.196542e-01 0.495 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.830256e-01 0.548 0 0
TBC/RABGAPs R-HSA-8854214 4.047485e-01 0.393 0 0
Cardiac conduction R-HSA-5576891 2.241370e-01 0.649 0 0
Signaling by ERBB4 R-HSA-1236394 3.130276e-01 0.504 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.949567e-01 0.530 0 0
Depurination R-HSA-73927 3.318903e-01 0.479 0 0
Diseases of DNA repair R-HSA-9675135 2.290424e-01 0.640 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 3.032055e-01 0.518 0 0
Lipid particle organization R-HSA-8964572 3.339799e-01 0.476 0 0
Nef and signal transduction R-HSA-164944 3.339799e-01 0.476 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.120840e-01 0.673 0 0
Synthesis of PG R-HSA-1483148 2.451387e-01 0.611 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.114907e-01 0.507 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 2.468062e-01 0.608 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.588095e-01 0.587 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.952086e-01 0.530 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.765523e-01 0.424 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 3.806413e-01 0.419 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 3.806413e-01 0.419 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.684768e-01 0.434 0 0
Aquaporin-mediated transport R-HSA-445717 3.785993e-01 0.422 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 3.684768e-01 0.434 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.927256e-01 0.406 0 0
Signal transduction by L1 R-HSA-445144 3.114907e-01 0.507 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 1.523736e-01 0.817 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 1.478687e-01 0.830 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.321975e-01 0.879 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 2.708877e-01 0.567 0 0
Glycosphingolipid transport R-HSA-9845576 3.074226e-01 0.512 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 3.077770e-01 0.512 0 0
Formation of the nephric duct R-HSA-9830364 4.081458e-01 0.389 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 3.077770e-01 0.512 0 0
Stimuli-sensing channels R-HSA-2672351 3.007317e-01 0.522 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.918060e-01 0.717 0 0
Depyrimidination R-HSA-73928 1.918060e-01 0.717 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.168003e-01 0.933 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.567384e-01 0.805 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.183954e-01 0.378 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.442825e-01 0.463 0 0
G1/S-Specific Transcription R-HSA-69205 3.074226e-01 0.512 0 0
MTOR signalling R-HSA-165159 3.927256e-01 0.406 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 3.279409e-01 0.484 0 0
Syndecan interactions R-HSA-3000170 3.765523e-01 0.424 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.188736e-01 0.925 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.633969e-01 0.440 0 0
Synaptic adhesion-like molecules R-HSA-8849932 2.783662e-01 0.555 0 0
Acyl chain remodelling of PS R-HSA-1482801 4.081458e-01 0.389 0 0
Triglyceride metabolism R-HSA-8979227 3.583444e-01 0.446 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 2.877312e-01 0.541 0 0
Triglyceride catabolism R-HSA-163560 3.074226e-01 0.512 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 3.619431e-01 0.441 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.783662e-01 0.555 0 0
Integrin signaling R-HSA-354192 2.588095e-01 0.587 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 3.604930e-01 0.443 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.729609e-01 0.762 0 0
Response to metal ions R-HSA-5660526 2.451387e-01 0.611 0 0
Plasma lipoprotein assembly R-HSA-8963898 1.554520e-01 0.808 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 4.236492e-01 0.373 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 4.236492e-01 0.373 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.236492e-01 0.373 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 4.285741e-01 0.368 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 4.285741e-01 0.368 0 0
Nucleosome assembly R-HSA-774815 4.285741e-01 0.368 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 4.285741e-01 0.368 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 4.285741e-01 0.368 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 4.285741e-01 0.368 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.285741e-01 0.368 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 4.288452e-01 0.368 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.336045e-01 0.363 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.389393e-01 0.358 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 4.389393e-01 0.358 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 4.389393e-01 0.358 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 4.389393e-01 0.358 0 0
Signaling by FGFR3 in disease R-HSA-5655332 4.389393e-01 0.358 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.389393e-01 0.358 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 4.403601e-01 0.356 0 0
Clathrin-mediated endocytosis R-HSA-8856828 4.414471e-01 0.355 0 0
Regulation of CDH11 function R-HSA-9762292 4.440886e-01 0.353 0 0
PI3K/AKT activation R-HSA-198203 4.440886e-01 0.353 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 4.440886e-01 0.353 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 4.440886e-01 0.353 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.440886e-01 0.353 0 0
Signal attenuation R-HSA-74749 4.440886e-01 0.353 0 0
Formation of intermediate mesoderm R-HSA-9761174 4.440886e-01 0.353 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 4.440886e-01 0.353 0 0
Receptor Mediated Mitophagy R-HSA-8934903 4.440886e-01 0.353 0 0
Maturation of spike protein R-HSA-9683686 4.440886e-01 0.353 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 4.440886e-01 0.353 0 0
Tandem pore domain potassium channels R-HSA-1296346 4.440886e-01 0.353 0 0
Signaling by Leptin R-HSA-2586552 4.440886e-01 0.353 0 0
SARS-CoV-2-host interactions R-HSA-9705683 4.443483e-01 0.352 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 4.540046e-01 0.343 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 4.540046e-01 0.343 0 0
HIV elongation arrest and recovery R-HSA-167287 4.540046e-01 0.343 0 0
Formation of the Early Elongation Complex R-HSA-113418 4.540046e-01 0.343 0 0
Pausing and recovery of HIV elongation R-HSA-167290 4.540046e-01 0.343 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 4.582936e-01 0.339 0 0
Base Excision Repair R-HSA-73884 4.623808e-01 0.335 0 0
GPER1 signaling R-HSA-9634597 4.636408e-01 0.334 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 4.636408e-01 0.334 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 4.682622e-01 0.330 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.686483e-01 0.329 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 4.686483e-01 0.329 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.686483e-01 0.329 0 0
Signaling by APC mutants R-HSA-4839744 4.686483e-01 0.329 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.686483e-01 0.329 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.686483e-01 0.329 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.686483e-01 0.329 0 0
FGFR2b ligand binding and activation R-HSA-190377 4.686483e-01 0.329 0 0
Interleukin-2 signaling R-HSA-9020558 4.686483e-01 0.329 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 4.686483e-01 0.329 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 4.686483e-01 0.329 0 0
Bicarbonate transporters R-HSA-425381 4.686483e-01 0.329 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.686483e-01 0.329 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 4.686483e-01 0.329 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 4.686483e-01 0.329 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 4.688353e-01 0.329 0 0
Late endosomal microautophagy R-HSA-9615710 4.688353e-01 0.329 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 4.688353e-01 0.329 0 0
Regulation of gene expression in beta cells R-HSA-210745 4.688353e-01 0.329 0 0
Cilium Assembly R-HSA-5617833 4.701712e-01 0.328 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.727686e-01 0.325 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.727686e-01 0.325 0 0
TCR signaling R-HSA-202403 4.727686e-01 0.325 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 4.749131e-01 0.323 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 4.818263e-01 0.317 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.834226e-01 0.316 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 4.834226e-01 0.316 0 0
DAP12 signaling R-HSA-2424491 4.834226e-01 0.316 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.834226e-01 0.316 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 4.834226e-01 0.316 0 0
Signaling by FGFR2 in disease R-HSA-5655253 4.864883e-01 0.313 0 0
Signaling by Insulin receptor R-HSA-74752 4.880598e-01 0.312 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.921243e-01 0.308 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 4.921243e-01 0.308 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 4.921243e-01 0.308 0 0
ERKs are inactivated R-HSA-202670 4.921243e-01 0.308 0 0
Signaling by AXIN mutants R-HSA-4839735 4.921243e-01 0.308 0 0
Signaling by AMER1 mutants R-HSA-4839748 4.921243e-01 0.308 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 4.921243e-01 0.308 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 4.921243e-01 0.308 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 4.921243e-01 0.308 0 0
Sodium/Calcium exchangers R-HSA-425561 4.921243e-01 0.308 0 0
Adipogenesis R-HSA-9843745 4.953192e-01 0.305 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 4.965234e-01 0.304 0 0
HSF1-dependent transactivation R-HSA-3371571 4.977344e-01 0.303 0 0
Meiotic recombination R-HSA-912446 4.977344e-01 0.303 0 0
The phototransduction cascade R-HSA-2514856 4.977344e-01 0.303 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 4.977592e-01 0.303 0 0
Trafficking of AMPA receptors R-HSA-399719 4.977592e-01 0.303 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 4.977592e-01 0.303 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.088550e-01 0.293 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 5.144105e-01 0.289 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 5.145646e-01 0.289 0 0
IRAK1 recruits IKK complex R-HSA-937039 5.145646e-01 0.289 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 5.145646e-01 0.289 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.145646e-01 0.289 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 5.145646e-01 0.289 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.145646e-01 0.289 0 0
Disorders of Nervous System Development R-HSA-9697154 5.145646e-01 0.289 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.145646e-01 0.289 0 0
Pervasive developmental disorders R-HSA-9005895 5.145646e-01 0.289 0 0
Interleukin-15 signaling R-HSA-8983432 5.145646e-01 0.289 0 0
OAS antiviral response R-HSA-8983711 5.145646e-01 0.289 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 5.198452e-01 0.284 0 0
Regulation of necroptotic cell death R-HSA-5675482 5.256557e-01 0.279 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 5.256557e-01 0.279 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 5.256557e-01 0.279 0 0
FGFR2c ligand binding and activation R-HSA-190375 5.360146e-01 0.271 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 5.360146e-01 0.271 0 0
FGFR4 ligand binding and activation R-HSA-190322 5.360146e-01 0.271 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 5.360146e-01 0.271 0 0
Chylomicron remodeling R-HSA-8963901 5.360146e-01 0.271 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 5.360146e-01 0.271 0 0
FGFR3 mutant receptor activation R-HSA-2033514 5.360146e-01 0.271 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.360146e-01 0.271 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 5.360146e-01 0.271 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 5.360146e-01 0.271 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 5.379906e-01 0.269 0 0
Cellular response to chemical stress R-HSA-9711123 5.381433e-01 0.269 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 5.392062e-01 0.268 0 0
Miscellaneous transport and binding events R-HSA-5223345 5.392062e-01 0.268 0 0
Signaling by NOTCH3 R-HSA-9012852 5.414172e-01 0.266 0 0
Interleukin-10 signaling R-HSA-6783783 5.437452e-01 0.265 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 5.457820e-01 0.263 0 0
Regulation of insulin secretion R-HSA-422356 5.460960e-01 0.263 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 5.460960e-01 0.263 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 5.460960e-01 0.263 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 5.460960e-01 0.263 0 0
DNA Repair R-HSA-73894 5.485106e-01 0.261 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 5.519912e-01 0.258 0 0
eNOS activation R-HSA-203615 5.524866e-01 0.258 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 5.524866e-01 0.258 0 0
NOD1/2 Signaling Pathway R-HSA-168638 5.524866e-01 0.258 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 5.527940e-01 0.257 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 5.527940e-01 0.257 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 5.557171e-01 0.255 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 5.557171e-01 0.255 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 5.565180e-01 0.255 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.565180e-01 0.255 0 0
FGFR3c ligand binding and activation R-HSA-190372 5.565180e-01 0.255 0 0
Signaling by FGFR4 in disease R-HSA-5655291 5.565180e-01 0.255 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.565180e-01 0.255 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 5.565180e-01 0.255 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.565180e-01 0.255 0 0
Regulation of KIT signaling R-HSA-1433559 5.565180e-01 0.255 0 0
Ciprofloxacin ADME R-HSA-9793528 5.565180e-01 0.255 0 0
Non-canonical inflammasome activation R-HSA-9686114 5.565180e-01 0.255 0 0
P2Y receptors R-HSA-417957 5.565180e-01 0.255 0 0
PTEN Regulation R-HSA-6807070 5.574152e-01 0.254 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 5.617468e-01 0.250 0 0
Hedgehog 'off' state R-HSA-5610787 5.621002e-01 0.250 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 5.654943e-01 0.248 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 5.654943e-01 0.248 0 0
Metabolism of RNA R-HSA-8953854 5.657071e-01 0.247 0 0
Cellular response to heat stress R-HSA-3371556 5.701575e-01 0.244 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 5.701575e-01 0.244 0 0
DCC mediated attractive signaling R-HSA-418885 5.761166e-01 0.239 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 5.761166e-01 0.239 0 0
SHC1 events in EGFR signaling R-HSA-180336 5.761166e-01 0.239 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 5.761166e-01 0.239 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 5.761166e-01 0.239 0 0
G beta:gamma signalling through BTK R-HSA-8964315 5.761166e-01 0.239 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.761166e-01 0.239 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 5.761166e-01 0.239 0 0
Signaling by Activin R-HSA-1502540 5.761166e-01 0.239 0 0
p38MAPK events R-HSA-171007 5.761166e-01 0.239 0 0
FGFR3 ligand binding and activation R-HSA-190239 5.761166e-01 0.239 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 5.761166e-01 0.239 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 5.761166e-01 0.239 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 5.761166e-01 0.239 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 5.772913e-01 0.239 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 5.772913e-01 0.239 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 5.778154e-01 0.238 0 0
HSF1 activation R-HSA-3371511 5.782276e-01 0.238 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 5.782276e-01 0.238 0 0
FGFR2 mutant receptor activation R-HSA-1839126 5.782276e-01 0.238 0 0
Extension of Telomeres R-HSA-180786 5.828268e-01 0.234 0 0
Regulation of beta-cell development R-HSA-186712 5.828268e-01 0.234 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 5.839119e-01 0.234 0 0
MHC class II antigen presentation R-HSA-2132295 5.843654e-01 0.233 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 5.913209e-01 0.228 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 5.928010e-01 0.227 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 5.932271e-01 0.227 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 5.948503e-01 0.226 0 0
Phase 4 - resting membrane potential R-HSA-5576886 5.948503e-01 0.226 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 5.948503e-01 0.226 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 5.948503e-01 0.226 0 0
Differentiation of T cells R-HSA-9945266 5.948503e-01 0.226 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 5.948503e-01 0.226 0 0
Activation of SMO R-HSA-5635838 5.948503e-01 0.226 0 0
Fructose catabolism R-HSA-70350 5.948503e-01 0.226 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.948503e-01 0.226 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 5.948503e-01 0.226 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 5.948503e-01 0.226 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.948503e-01 0.226 0 0
SARS-CoV-2 Infection R-HSA-9694516 5.988801e-01 0.223 0 0
MAP kinase activation R-HSA-450294 6.026195e-01 0.220 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 6.028667e-01 0.220 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 6.028667e-01 0.220 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 6.052166e-01 0.218 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 6.052166e-01 0.218 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 6.052166e-01 0.218 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 6.122805e-01 0.213 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 6.122805e-01 0.213 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 6.127570e-01 0.213 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 6.127570e-01 0.213 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 6.127570e-01 0.213 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 6.127570e-01 0.213 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.127570e-01 0.213 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 6.127570e-01 0.213 0 0
Passive transport by Aquaporins R-HSA-432047 6.127570e-01 0.213 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 6.127570e-01 0.213 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 6.147721e-01 0.211 0 0
Signaling by ALK R-HSA-201556 6.147721e-01 0.211 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 6.215445e-01 0.207 0 0
Signaling by NTRKs R-HSA-166520 6.221370e-01 0.206 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 6.254851e-01 0.204 0 0
Interleukin-2 family signaling R-HSA-451927 6.264021e-01 0.203 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 6.298734e-01 0.201 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 6.298734e-01 0.201 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 6.298734e-01 0.201 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 6.298734e-01 0.201 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 6.298734e-01 0.201 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.298734e-01 0.201 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.298734e-01 0.201 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.298734e-01 0.201 0 0
Sulfide oxidation to sulfate R-HSA-1614517 6.298734e-01 0.201 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 6.303478e-01 0.200 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 6.311247e-01 0.200 0 0
Immune System R-HSA-168256 6.341040e-01 0.198 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 6.375202e-01 0.196 0 0
Selective autophagy R-HSA-9663891 6.376540e-01 0.195 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 6.377576e-01 0.195 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 6.377576e-01 0.195 0 0
Cellular response to hypoxia R-HSA-1234174 6.403057e-01 0.194 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 6.462342e-01 0.190 0 0
GAB1 signalosome R-HSA-180292 6.462342e-01 0.190 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.462342e-01 0.190 0 0
Activated point mutants of FGFR2 R-HSA-2033519 6.462342e-01 0.190 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.462342e-01 0.190 0 0
Presynaptic function of Kainate receptors R-HSA-500657 6.462342e-01 0.190 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 6.462342e-01 0.190 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 6.462342e-01 0.190 0 0
Tie2 Signaling R-HSA-210993 6.462342e-01 0.190 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 6.462342e-01 0.190 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.462342e-01 0.190 0 0
Interleukin-1 family signaling R-HSA-446652 6.465126e-01 0.189 0 0
Adaptive Immune System R-HSA-1280218 6.480326e-01 0.188 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.488404e-01 0.188 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 6.488404e-01 0.188 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 6.488404e-01 0.188 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 6.488404e-01 0.188 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 6.558216e-01 0.183 0 0
Metabolism of steroid hormones R-HSA-196071 6.581823e-01 0.182 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 6.618728e-01 0.179 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.618728e-01 0.179 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.618728e-01 0.179 0 0
The NLRP3 inflammasome R-HSA-844456 6.618728e-01 0.179 0 0
Other interleukin signaling R-HSA-449836 6.618728e-01 0.179 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 6.641761e-01 0.178 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 6.653376e-01 0.177 0 0
Transcription of the HIV genome R-HSA-167172 6.668772e-01 0.176 0 0
Autophagy R-HSA-9612973 6.699428e-01 0.174 0 0
Defective pyroptosis R-HSA-9710421 6.701953e-01 0.174 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 6.759353e-01 0.170 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 6.768209e-01 0.170 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.768209e-01 0.170 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 6.768209e-01 0.170 0 0
Pregnenolone biosynthesis R-HSA-196108 6.768209e-01 0.170 0 0
DAP12 interactions R-HSA-2172127 6.804724e-01 0.167 0 0
RMTs methylate histone arginines R-HSA-3214858 6.804724e-01 0.167 0 0
Interleukin-17 signaling R-HSA-448424 6.837799e-01 0.165 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 6.852653e-01 0.164 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 6.904864e-01 0.161 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 6.911091e-01 0.160 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 6.911091e-01 0.160 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 6.911091e-01 0.160 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 6.911091e-01 0.160 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 6.911091e-01 0.160 0 0
FGFR2 ligand binding and activation R-HSA-190241 6.911091e-01 0.160 0 0
G-protein activation R-HSA-202040 6.911091e-01 0.160 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.911091e-01 0.160 0 0
Signalling to RAS R-HSA-167044 6.911091e-01 0.160 0 0
ERK/MAPK targets R-HSA-198753 6.911091e-01 0.160 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 6.911091e-01 0.160 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 6.911091e-01 0.160 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.911091e-01 0.160 0 0
Basigin interactions R-HSA-210991 6.911091e-01 0.160 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 6.919881e-01 0.160 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 6.919881e-01 0.160 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 6.919881e-01 0.160 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 7.000349e-01 0.155 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 7.002405e-01 0.155 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 7.002405e-01 0.155 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 7.002405e-01 0.155 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 7.002405e-01 0.155 0 0
Ribosome-associated quality control R-HSA-9948299 7.002411e-01 0.155 0 0
Signaling by Hedgehog R-HSA-5358351 7.002411e-01 0.155 0 0
rRNA processing R-HSA-72312 7.008580e-01 0.154 0 0
Rab regulation of trafficking R-HSA-9007101 7.043767e-01 0.152 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 7.047664e-01 0.152 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.047664e-01 0.152 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 7.047664e-01 0.152 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.047664e-01 0.152 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 7.047664e-01 0.152 0 0
Mitochondrial calcium ion transport R-HSA-8949215 7.047664e-01 0.152 0 0
Signaling by PDGFR in disease R-HSA-9671555 7.047664e-01 0.152 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 7.097380e-01 0.149 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 7.097380e-01 0.149 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.101843e-01 0.149 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 7.113174e-01 0.148 0 0
Signaling by NOTCH4 R-HSA-9013694 7.156469e-01 0.145 0 0
Macroautophagy R-HSA-1632852 7.172716e-01 0.144 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.178207e-01 0.144 0 0
FGFR2 alternative splicing R-HSA-6803529 7.178207e-01 0.144 0 0
Notch-HLH transcription pathway R-HSA-350054 7.178207e-01 0.144 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.178207e-01 0.144 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.178207e-01 0.144 0 0
Fructose metabolism R-HSA-5652084 7.178207e-01 0.144 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.178207e-01 0.144 0 0
mTORC1-mediated signalling R-HSA-166208 7.178207e-01 0.144 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 7.178207e-01 0.144 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.178207e-01 0.144 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 7.197862e-01 0.143 0 0
Ion channel transport R-HSA-983712 7.214804e-01 0.142 0 0
Protein ubiquitination R-HSA-8852135 7.232139e-01 0.141 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 7.232139e-01 0.141 0 0
Degradation of CDH1 R-HSA-9766229 7.279780e-01 0.138 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 7.302985e-01 0.136 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 7.302985e-01 0.136 0 0
Growth hormone receptor signaling R-HSA-982772 7.302985e-01 0.136 0 0
Toll-like Receptor Cascades R-HSA-168898 7.310425e-01 0.136 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.367282e-01 0.133 0 0
Translation of Structural Proteins R-HSA-9694635 7.378752e-01 0.132 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 7.422253e-01 0.129 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 7.422253e-01 0.129 0 0
Thromboxane signalling through TP receptor R-HSA-428930 7.422253e-01 0.129 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.422253e-01 0.129 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 7.422253e-01 0.129 0 0
Deadenylation of mRNA R-HSA-429947 7.422253e-01 0.129 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 7.422253e-01 0.129 0 0
TNFs bind their physiological receptors R-HSA-5669034 7.422253e-01 0.129 0 0
Interleukin-1 signaling R-HSA-9020702 7.437932e-01 0.129 0 0
Host Interactions of HIV factors R-HSA-162909 7.457703e-01 0.127 0 0
Membrane Trafficking R-HSA-199991 7.496161e-01 0.125 0 0
Regulation of endogenous retroelements R-HSA-9842860 7.499432e-01 0.125 0 0
SARS-CoV Infections R-HSA-9679506 7.530350e-01 0.123 1 0
RNA Polymerase I Promoter Escape R-HSA-73772 7.535095e-01 0.123 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.535095e-01 0.123 0 0
G alpha (s) signalling events R-HSA-418555 7.536231e-01 0.123 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 7.536253e-01 0.123 0 0
Alpha-oxidation of phytanate R-HSA-389599 7.536253e-01 0.123 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 7.536253e-01 0.123 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 7.536253e-01 0.123 0 0
Interleukin-7 signaling R-HSA-1266695 7.536253e-01 0.123 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.587050e-01 0.120 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.615490e-01 0.118 0 0
Signaling by EGFR in Cancer R-HSA-1643713 7.645218e-01 0.117 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 7.645218e-01 0.117 0 0
Metalloprotease DUBs R-HSA-5689901 7.645218e-01 0.117 0 0
Abacavir ADME R-HSA-2161522 7.645218e-01 0.117 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.645218e-01 0.117 0 0
Amyloid fiber formation R-HSA-977225 7.653443e-01 0.116 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 7.749371e-01 0.111 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.749371e-01 0.111 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 7.749371e-01 0.111 0 0
Cristae formation R-HSA-8949613 7.749371e-01 0.111 0 0
Triglyceride biosynthesis R-HSA-75109 7.749371e-01 0.111 0 0
Synthesis of PE R-HSA-1483213 7.749371e-01 0.111 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 7.749371e-01 0.111 0 0
Signaling by BMP R-HSA-201451 7.749371e-01 0.111 0 0
Neuronal System R-HSA-112316 7.762832e-01 0.110 0 0
HDACs deacetylate histones R-HSA-3214815 7.769479e-01 0.110 0 0
Platelet homeostasis R-HSA-418346 7.790023e-01 0.108 0 0
HIV Infection R-HSA-162906 7.832432e-01 0.106 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 7.836846e-01 0.106 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 7.843162e-01 0.106 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.843162e-01 0.106 0 0
Inflammasomes R-HSA-622312 7.848923e-01 0.105 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.848923e-01 0.105 0 0
Influenza Infection R-HSA-168255 7.893021e-01 0.103 0 0
Regulation of CDH1 Function R-HSA-9764561 7.914698e-01 0.102 0 0
Synthesis of PA R-HSA-1483166 7.914698e-01 0.102 0 0
DNA methylation R-HSA-5334118 7.944077e-01 0.100 0 0
Thyroxine biosynthesis R-HSA-209968 7.944077e-01 0.100 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 7.944077e-01 0.100 0 0
mRNA Capping R-HSA-72086 7.944077e-01 0.100 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 7.944077e-01 0.100 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 7.944077e-01 0.100 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 7.944077e-01 0.100 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 7.963379e-01 0.099 0 0
Dual incision in TC-NER R-HSA-6782135 7.984131e-01 0.098 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 8.018990e-01 0.096 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 8.021092e-01 0.096 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 8.035027e-01 0.095 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.035027e-01 0.095 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 8.035027e-01 0.095 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.035027e-01 0.095 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.035027e-01 0.095 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 8.035027e-01 0.095 0 0
Activation of BH3-only proteins R-HSA-114452 8.035027e-01 0.095 0 0
snRNP Assembly R-HSA-191859 8.051509e-01 0.094 0 0
Metabolism of non-coding RNA R-HSA-194441 8.051509e-01 0.094 0 0
Cellular response to starvation R-HSA-9711097 8.052645e-01 0.094 0 0
FCERI mediated MAPK activation R-HSA-2871796 8.102707e-01 0.091 0 0
Signaling by Retinoic Acid R-HSA-5362517 8.116878e-01 0.091 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 8.121959e-01 0.090 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 8.121959e-01 0.090 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 8.121959e-01 0.090 0 0
Budding and maturation of HIV virion R-HSA-162588 8.121959e-01 0.090 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.121959e-01 0.090 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 8.121959e-01 0.090 0 0
Downstream signal transduction R-HSA-186763 8.121959e-01 0.090 0 0
Formation of paraxial mesoderm R-HSA-9793380 8.180282e-01 0.087 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.197140e-01 0.086 0 0
Inwardly rectifying K+ channels R-HSA-1296065 8.205051e-01 0.086 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.241767e-01 0.084 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 8.241767e-01 0.084 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 8.284471e-01 0.082 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 8.284471e-01 0.082 0 0
Nuclear RNA decay R-HSA-9930044 8.284471e-01 0.082 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 8.284471e-01 0.082 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 8.284471e-01 0.082 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 8.289400e-01 0.081 0 0
Selenoamino acid metabolism R-HSA-2408522 8.293595e-01 0.081 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 8.360381e-01 0.078 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 8.360381e-01 0.078 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 8.360381e-01 0.078 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.360381e-01 0.078 0 0
Heme degradation R-HSA-189483 8.360381e-01 0.078 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.387669e-01 0.076 0 0
Organelle biogenesis and maintenance R-HSA-1852241 8.401615e-01 0.076 0 0
Phospholipid metabolism R-HSA-1483257 8.411100e-01 0.075 0 0
Nuclear import of Rev protein R-HSA-180746 8.432937e-01 0.074 0 0
Signal amplification R-HSA-392518 8.432937e-01 0.074 0 0
Mitophagy R-HSA-5205647 8.432937e-01 0.074 0 0
Calnexin/calreticulin cycle R-HSA-901042 8.432937e-01 0.074 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.432937e-01 0.074 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.432937e-01 0.074 0 0
Late Phase of HIV Life Cycle R-HSA-162599 8.477677e-01 0.072 0 0
Mitochondrial protein degradation R-HSA-9837999 8.481026e-01 0.072 0 0
Collagen formation R-HSA-1474290 8.481026e-01 0.072 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 8.502287e-01 0.070 0 0
Regulation of Apoptosis R-HSA-169911 8.502287e-01 0.070 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 8.502287e-01 0.070 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.502287e-01 0.070 0 0
Oncogene Induced Senescence R-HSA-2559585 8.502287e-01 0.070 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 8.502287e-01 0.070 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 8.502287e-01 0.070 0 0
HCMV Early Events R-HSA-9609690 8.520026e-01 0.070 0 0
Kidney development R-HSA-9830369 8.522004e-01 0.069 0 0
Platelet activation, signaling and aggregation R-HSA-76002 8.538636e-01 0.069 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.568571e-01 0.067 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.568571e-01 0.067 0 0
RNA Polymerase III Transcription R-HSA-74158 8.568571e-01 0.067 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.568571e-01 0.067 0 0
RUNX2 regulates bone development R-HSA-8941326 8.568571e-01 0.067 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 8.572924e-01 0.067 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 8.572924e-01 0.067 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 8.612241e-01 0.065 0 0
Potassium Channels R-HSA-1296071 8.612241e-01 0.065 0 0
Voltage gated Potassium channels R-HSA-1296072 8.631926e-01 0.064 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 8.631926e-01 0.064 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 8.631926e-01 0.064 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 8.631926e-01 0.064 0 0
Collagen chain trimerization R-HSA-8948216 8.631926e-01 0.064 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 8.669984e-01 0.062 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 8.669984e-01 0.062 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.672971e-01 0.062 0 0
Neutrophil degranulation R-HSA-6798695 8.688775e-01 0.061 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 8.692480e-01 0.061 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.692480e-01 0.061 0 0
G alpha (i) signalling events R-HSA-418594 8.694944e-01 0.061 0 0
Hedgehog 'on' state R-HSA-5632684 8.716209e-01 0.060 0 0
Metabolism of cofactors R-HSA-8978934 8.716209e-01 0.060 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.723446e-01 0.059 0 0
Pentose phosphate pathway R-HSA-71336 8.750358e-01 0.058 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 8.750358e-01 0.058 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 8.750358e-01 0.058 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 8.750358e-01 0.058 0 0
RAS processing R-HSA-9648002 8.750358e-01 0.058 0 0
Potential therapeutics for SARS R-HSA-9679191 8.753053e-01 0.058 1 1
Transcriptional regulation by small RNAs R-HSA-5578749 8.760951e-01 0.057 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 8.760951e-01 0.057 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 8.760951e-01 0.057 0 0
Switching of origins to a post-replicative state R-HSA-69052 8.804252e-01 0.055 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 8.805677e-01 0.055 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 8.805677e-01 0.055 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 8.805677e-01 0.055 0 0
Diseases of Immune System R-HSA-5260271 8.805677e-01 0.055 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.805677e-01 0.055 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.805677e-01 0.055 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 8.805677e-01 0.055 0 0
Platelet degranulation R-HSA-114608 8.829546e-01 0.054 0 0
PI Metabolism R-HSA-1483255 8.845114e-01 0.053 0 0
ROS and RNS production in phagocytes R-HSA-1222556 8.846152e-01 0.053 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 8.858550e-01 0.053 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 8.886689e-01 0.051 0 0
ISG15 antiviral mechanism R-HSA-1169408 8.886689e-01 0.051 0 0
Translation of Structural Proteins R-HSA-9683701 8.909086e-01 0.050 0 0
Heme biosynthesis R-HSA-189451 8.909086e-01 0.050 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 8.925902e-01 0.049 0 0
Signaling by NOTCH1 R-HSA-1980143 8.925902e-01 0.049 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 8.957387e-01 0.048 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 8.957387e-01 0.048 0 0
HIV Life Cycle R-HSA-162587 8.958174e-01 0.048 0 0
Nucleotide Excision Repair R-HSA-5696398 8.980363e-01 0.047 0 0
RNA Polymerase I Transcription R-HSA-73864 9.000506e-01 0.046 0 0
Cholesterol biosynthesis R-HSA-191273 9.000506e-01 0.046 0 0
Integrin cell surface interactions R-HSA-216083 9.000506e-01 0.046 0 0
Signaling by NOTCH R-HSA-157118 9.002856e-01 0.046 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.003553e-01 0.046 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.003553e-01 0.046 0 0
Surfactant metabolism R-HSA-5683826 9.047677e-01 0.043 0 0
Transmission across Chemical Synapses R-HSA-112315 9.056987e-01 0.043 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.089849e-01 0.041 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 9.089849e-01 0.041 0 0
Somitogenesis R-HSA-9824272 9.089849e-01 0.041 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.089849e-01 0.041 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.089849e-01 0.041 0 0
Hemostasis R-HSA-109582 9.128062e-01 0.040 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.130157e-01 0.040 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 9.130157e-01 0.040 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.166392e-01 0.038 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.168682e-01 0.038 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.168682e-01 0.038 0 0
Synthesis of PC R-HSA-1483191 9.168682e-01 0.038 0 0
Inositol phosphate metabolism R-HSA-1483249 9.183127e-01 0.037 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 9.196307e-01 0.036 0 0
SLC transporter disorders R-HSA-5619102 9.200298e-01 0.036 0 0
HCMV Infection R-HSA-9609646 9.202177e-01 0.036 0 0
Intraflagellar transport R-HSA-5620924 9.205503e-01 0.036 0 0
NGF-stimulated transcription R-HSA-9031628 9.205503e-01 0.036 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.205503e-01 0.036 0 0
Gluconeogenesis R-HSA-70263 9.205503e-01 0.036 0 0
Metal ion SLC transporters R-HSA-425410 9.205503e-01 0.036 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.208888e-01 0.036 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 9.240695e-01 0.034 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.240695e-01 0.034 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.258994e-01 0.033 0 0
XBP1(S) activates chaperone genes R-HSA-381038 9.280103e-01 0.032 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.304672e-01 0.031 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.306478e-01 0.031 0 0
Complex IV assembly R-HSA-9864848 9.306478e-01 0.031 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.306478e-01 0.031 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 9.320446e-01 0.031 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.337203e-01 0.030 0 0
Orc1 removal from chromatin R-HSA-68949 9.337203e-01 0.030 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.337203e-01 0.030 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.366568e-01 0.028 0 0
Neurotransmitter release cycle R-HSA-112310 9.379056e-01 0.028 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.394635e-01 0.027 0 0
Visual phototransduction R-HSA-2187338 9.397639e-01 0.027 0 0
Innate Immune System R-HSA-168249 9.406398e-01 0.027 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.421459e-01 0.026 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.421459e-01 0.026 0 0
G alpha (z) signalling events R-HSA-418597 9.421459e-01 0.026 0 0
Paracetamol ADME R-HSA-9753281 9.421459e-01 0.026 0 0
IRE1alpha activates chaperones R-HSA-381070 9.423556e-01 0.026 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.447096e-01 0.025 0 0
Digestion R-HSA-8935690 9.447096e-01 0.025 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.447096e-01 0.025 0 0
Assembly of the pre-replicative complex R-HSA-68867 9.465014e-01 0.024 0 0
Formation of the cornified envelope R-HSA-6809371 9.482435e-01 0.023 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.495017e-01 0.023 0 0
Peroxisomal protein import R-HSA-9033241 9.517399e-01 0.021 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 9.517399e-01 0.021 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.517399e-01 0.021 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.521917e-01 0.021 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.531605e-01 0.021 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 9.538790e-01 0.021 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 9.538790e-01 0.021 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 9.538790e-01 0.021 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 9.538790e-01 0.021 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 9.538790e-01 0.021 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 9.538790e-01 0.021 0 0
GABA receptor activation R-HSA-977443 9.538790e-01 0.021 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.539565e-01 0.020 0 0
Extracellular matrix organization R-HSA-1474244 9.550180e-01 0.020 0 0
HCMV Late Events R-HSA-9610379 9.554978e-01 0.020 0 0
Viral Messenger RNA Synthesis R-HSA-168325 9.559234e-01 0.020 0 0
Collagen degradation R-HSA-1442490 9.559234e-01 0.020 0 0
tRNA processing in the nucleus R-HSA-6784531 9.578773e-01 0.019 0 0
Heme signaling R-HSA-9707616 9.578773e-01 0.019 0 0
Signaling by PDGF R-HSA-186797 9.578773e-01 0.019 0 0
Digestion and absorption R-HSA-8963743 9.597448e-01 0.018 0 0
Neddylation R-HSA-8951664 9.607610e-01 0.017 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.615295e-01 0.017 0 0
Ion transport by P-type ATPases R-HSA-936837 9.615295e-01 0.017 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.625773e-01 0.017 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.648654e-01 0.016 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.664234e-01 0.015 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.664234e-01 0.015 0 0
RSV-host interactions R-HSA-9833110 9.672683e-01 0.014 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.672683e-01 0.014 0 0
Co-inhibition by PD-1 R-HSA-389948 9.693471e-01 0.014 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.698334e-01 0.013 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.706954e-01 0.013 0 0
Synthesis of DNA R-HSA-69239 9.708174e-01 0.013 0 0
Gene Silencing by RNA R-HSA-211000 9.708174e-01 0.013 0 0
Vesicle-mediated transport R-HSA-5653656 9.715450e-01 0.013 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.719157e-01 0.012 0 0
Metabolism of porphyrins R-HSA-189445 9.719952e-01 0.012 0 0
ECM proteoglycans R-HSA-3000178 9.719952e-01 0.012 0 0
Retinoid metabolism and transport R-HSA-975634 9.719952e-01 0.012 0 0
Metabolism of steroids R-HSA-8957322 9.728866e-01 0.012 0 0
DNA Replication Pre-Initiation R-HSA-69002 9.729741e-01 0.012 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 9.732374e-01 0.012 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.738383e-01 0.012 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.738383e-01 0.012 0 0
Iron uptake and transport R-HSA-917937 9.766435e-01 0.010 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.766435e-01 0.010 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.771153e-01 0.010 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.793756e-01 0.009 0 0
ABC transporter disorders R-HSA-5619084 9.796166e-01 0.009 0 0
PCP/CE pathway R-HSA-4086400 9.796166e-01 0.009 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.801607e-01 0.009 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.810566e-01 0.008 0 0
PKR-mediated signaling R-HSA-9833482 9.813856e-01 0.008 0 0
Mitochondrial biogenesis R-HSA-1592230 9.816450e-01 0.008 0 0
Peptide hormone metabolism R-HSA-2980736 9.816450e-01 0.008 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.822117e-01 0.008 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.822117e-01 0.008 0 0
Leishmania infection R-HSA-9658195 9.825220e-01 0.008 0 0
Parasitic Infection Pathways R-HSA-9824443 9.825220e-01 0.008 0 0
Protein localization R-HSA-9609507 9.833044e-01 0.007 0 0
DNA Replication R-HSA-69306 9.833044e-01 0.007 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.837558e-01 0.007 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 9.838837e-01 0.007 0 0
Viral Infection Pathways R-HSA-9824446 9.839629e-01 0.007 1 0
PPARA activates gene expression R-HSA-1989781 9.844438e-01 0.007 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.844768e-01 0.007 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.844768e-01 0.007 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.855085e-01 0.006 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.858245e-01 0.006 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.864539e-01 0.006 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.870553e-01 0.006 0 0
ER-Phagosome pathway R-HSA-1236974 9.881794e-01 0.005 0 0
Downstream TCR signaling R-HSA-202424 9.887043e-01 0.005 0 0
Protein folding R-HSA-391251 9.901435e-01 0.004 0 0
Circadian clock R-HSA-9909396 9.905878e-01 0.004 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.905878e-01 0.004 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.908004e-01 0.004 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.921468e-01 0.003 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.928292e-01 0.003 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.931479e-01 0.003 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.931529e-01 0.003 0 0
ABC-family proteins mediated transport R-HSA-382556 9.934524e-01 0.003 0 0
Disease R-HSA-1643685 9.941448e-01 0.003 1 0
Peptide ligand-binding receptors R-HSA-375276 9.951114e-01 0.002 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.952257e-01 0.002 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.960296e-01 0.002 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.968375e-01 0.001 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.970508e-01 0.001 0 0
Interferon gamma signaling R-HSA-877300 9.970595e-01 0.001 0 0
Sphingolipid metabolism R-HSA-428157 9.972010e-01 0.001 0 0
Keratinization R-HSA-6805567 9.977658e-01 0.001 0 0
tRNA processing R-HSA-72306 9.981963e-01 0.001 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.987279e-01 0.001 0 0
Leishmania phagocytosis R-HSA-9664417 9.991935e-01 0.000 0 0
Parasite infection R-HSA-9664407 9.991935e-01 0.000 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.991935e-01 0.000 0 0
Translation R-HSA-72766 9.994469e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.995183e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.996288e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.996452e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.997158e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.997501e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.998508e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.998701e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.998813e-01 0.000 1 0
Metabolism of nucleotides R-HSA-15869 9.998889e-01 0.000 0 0
Interferon Signaling R-HSA-913531 9.999397e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999534e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999641e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999801e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999859e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999958e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999991e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999998e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999999e-01 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
M Phase R-HSA-68886 1.110223e-16 15.955 0 0
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 0 0
Cell Cycle, Mitotic R-HSA-69278 1.110223e-16 15.955 0 0
Axon guidance R-HSA-422475 1.110223e-16 15.955 1 0
Cellular responses to stimuli R-HSA-8953897 1.110223e-16 15.955 0 0
Cellular responses to stress R-HSA-2262752 1.110223e-16 15.955 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.220446e-16 15.654 0 0
Nervous system development R-HSA-9675108 1.110223e-15 14.955 1 0
Cellular Senescence R-HSA-2559583 1.443290e-15 14.841 0 0
Mitotic Prophase R-HSA-68875 1.484368e-13 12.828 0 0
Cellular response to heat stress R-HSA-3371556 1.804112e-13 12.744 0 0
Nucleosome assembly R-HSA-774815 2.416956e-13 12.617 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 2.416956e-13 12.617 0 0
Signaling by ROBO receptors R-HSA-376176 2.357003e-13 12.628 0 0
Cell Cycle Checkpoints R-HSA-69620 3.591571e-13 12.445 0 0
PRC2 methylates histones and DNA R-HSA-212300 5.144773e-13 12.289 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.979417e-12 11.703 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.979417e-12 11.703 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.372325e-12 11.625 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.348899e-12 11.629 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.282707e-12 11.484 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.536038e-12 11.343 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.536038e-12 11.343 0 0
Metabolism of RNA R-HSA-8953854 5.170753e-12 11.286 0 0
Eukaryotic Translation Elongation R-HSA-156842 6.986633e-12 11.156 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 7.065570e-12 11.151 0 0
Packaging Of Telomere Ends R-HSA-171306 9.049650e-12 11.043 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 8.375967e-12 11.077 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 8.607892e-12 11.065 0 0
Assembly of the pre-replicative complex R-HSA-68867 8.624434e-12 11.064 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.049650e-12 11.043 0 0
Defective pyroptosis R-HSA-9710421 9.342194e-12 11.030 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.052902e-11 10.978 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.167200e-11 10.933 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.167200e-11 10.933 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 2.104705e-11 10.677 0 0
DNA methylation R-HSA-5334118 2.130673e-11 10.671 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.262324e-11 10.645 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 2.262324e-11 10.645 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.379685e-11 10.623 0 0
Meiotic synapsis R-HSA-1221632 2.511058e-11 10.600 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.545397e-11 10.594 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 4.374678e-11 10.359 0 0
Influenza Infection R-HSA-168255 4.344936e-11 10.362 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 4.402567e-11 10.356 0 0
DNA Replication Pre-Initiation R-HSA-69002 5.242629e-11 10.280 0 0
Cleavage of the damaged purine R-HSA-110331 6.612244e-11 10.180 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 7.051848e-11 10.152 0 0
Peptide chain elongation R-HSA-156902 8.079193e-11 10.093 0 0
Diseases of programmed cell death R-HSA-9645723 8.079193e-11 10.093 0 0
Depurination R-HSA-73927 9.284196e-11 10.032 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 9.796686e-11 10.009 0 0
HSF1-dependent transactivation R-HSA-3371571 1.057042e-10 9.976 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.075707e-10 9.968 0 0
Adherens junctions interactions R-HSA-418990 1.125265e-10 9.949 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.633667e-10 9.787 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.794115e-10 9.746 0 0
Attenuation phase R-HSA-3371568 1.785491e-10 9.748 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.447255e-10 9.611 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 2.447255e-10 9.611 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 2.695116e-10 9.569 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 2.907367e-10 9.537 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 3.836920e-10 9.416 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.072973e-10 9.390 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 4.498237e-10 9.347 0 0
Depyrimidination R-HSA-73928 4.498237e-10 9.347 0 0
Cell junction organization R-HSA-446728 4.876622e-10 9.312 0 0
Cell-Cell communication R-HSA-1500931 5.606110e-10 9.251 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 5.654055e-10 9.248 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 8.408243e-10 9.075 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.030759e-10 9.044 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.072625e-09 8.970 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.403519e-09 8.853 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.622671e-09 8.790 0 0
HDACs deacetylate histones R-HSA-3214815 2.073834e-09 8.683 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.037949e-09 8.691 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.037949e-09 8.691 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.965796e-09 8.706 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.331497e-09 8.632 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.391768e-09 8.621 0 0
Chromosome Maintenance R-HSA-73886 2.467917e-09 8.608 0 0
Amyloid fiber formation R-HSA-977225 2.753619e-09 8.560 0 0
Cell-cell junction organization R-HSA-421270 3.766541e-09 8.424 0 0
Mitotic Anaphase R-HSA-68882 3.933140e-09 8.405 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.050598e-09 8.392 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 4.367950e-09 8.360 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 4.857656e-09 8.314 0 0
DNA Double Strand Break Response R-HSA-5693606 5.092452e-09 8.293 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.636903e-09 8.249 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 6.518014e-09 8.186 0 0
Regulation of endogenous retroelements R-HSA-9842860 7.514113e-09 8.124 0 0
RNA Polymerase I Transcription R-HSA-73864 8.284339e-09 8.082 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.438255e-09 8.025 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.024963e-08 7.989 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.032380e-08 7.986 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.168121e-08 7.933 0 0
Eukaryotic Translation Termination R-HSA-72764 1.128471e-08 7.948 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.191772e-08 7.924 0 0
Developmental Biology R-HSA-1266738 1.376193e-08 7.861 1 0
Processing of DNA double-strand break ends R-HSA-5693607 1.446609e-08 7.840 0 0
Separation of Sister Chromatids R-HSA-2467813 1.883299e-08 7.725 0 0
DNA Replication R-HSA-69306 1.886598e-08 7.724 0 0
Gene Silencing by RNA R-HSA-211000 1.909031e-08 7.719 0 0
HSF1 activation R-HSA-3371511 2.593063e-08 7.586 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.570542e-08 7.590 0 0
Selenocysteine synthesis R-HSA-2408557 2.929830e-08 7.533 0 0
Meiosis R-HSA-1500620 2.937066e-08 7.532 0 0
Meiotic recombination R-HSA-912446 3.265749e-08 7.486 0 0
Viral mRNA Translation R-HSA-192823 3.969391e-08 7.401 0 0
Mitotic Prometaphase R-HSA-68877 4.137744e-08 7.383 0 0
Activation of HOX genes during differentiation R-HSA-5619507 5.341571e-08 7.272 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 5.341571e-08 7.272 0 0
HCMV Early Events R-HSA-9609690 5.620816e-08 7.250 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 6.160432e-08 7.210 0 0
Telomere Maintenance R-HSA-157579 7.099281e-08 7.149 0 0
Base Excision Repair R-HSA-73884 7.935265e-08 7.100 0 0
Recycling pathway of L1 R-HSA-437239 8.114185e-08 7.091 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.051582e-07 6.978 0 0
G2/M Checkpoints R-HSA-69481 1.096582e-07 6.960 0 0
Ribosome-associated quality control R-HSA-9948299 1.423315e-07 6.847 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.749281e-07 6.757 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.765554e-07 6.753 0 0
rRNA processing R-HSA-72312 1.862353e-07 6.730 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.910911e-07 6.719 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.251751e-07 6.647 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.422409e-07 6.616 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.927899e-07 6.533 0 0
Viral Infection Pathways R-HSA-9824446 3.038348e-07 6.517 1 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.287691e-07 6.483 0 0
Homology Directed Repair R-HSA-5693538 4.619734e-07 6.335 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 5.441460e-07 6.264 0 0
Co-inhibition by PD-1 R-HSA-389948 8.203201e-07 6.086 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 8.370990e-07 6.077 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.707456e-07 6.013 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.339397e-06 5.873 0 0
Signaling by ALK in cancer R-HSA-9700206 1.339397e-06 5.873 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.439293e-06 5.842 0 0
Smooth Muscle Contraction R-HSA-445355 1.623684e-06 5.789 0 0
HATs acetylate histones R-HSA-3214847 1.654873e-06 5.781 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.883423e-06 5.725 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.274328e-06 5.643 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.274328e-06 5.643 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.274328e-06 5.643 0 0
Signaling by RAS mutants R-HSA-6802949 2.274328e-06 5.643 0 0
HCMV Infection R-HSA-9609646 2.299482e-06 5.638 0 0
Apoptotic execution phase R-HSA-75153 2.274328e-06 5.643 0 0
Reproduction R-HSA-1474165 2.331570e-06 5.632 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.388518e-06 5.622 0 0
Selenoamino acid metabolism R-HSA-2408522 2.474831e-06 5.606 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.734920e-06 5.563 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.759469e-06 5.559 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.013807e-06 5.521 0 0
Aggrephagy R-HSA-9646399 3.073271e-06 5.512 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.172334e-06 5.499 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.172334e-06 5.499 0 0
Interleukin-12 signaling R-HSA-9020591 3.227324e-06 5.491 0 0
Epigenetic regulation of gene expression R-HSA-212165 3.262341e-06 5.486 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 3.324277e-06 5.478 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 3.588239e-06 5.445 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 3.889991e-06 5.410 0 0
Cellular response to starvation R-HSA-9711097 4.408884e-06 5.356 0 0
Signaling by RAF1 mutants R-HSA-9656223 4.662160e-06 5.331 0 0
L1CAM interactions R-HSA-373760 4.910906e-06 5.309 0 0
Chromatin modifying enzymes R-HSA-3247509 5.049731e-06 5.297 0 0
TCF dependent signaling in response to WNT R-HSA-201681 4.925176e-06 5.308 0 0
Muscle contraction R-HSA-397014 7.016587e-06 5.154 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 7.043728e-06 5.152 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 9.426328e-06 5.026 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 9.533708e-06 5.021 0 0
Protein ubiquitination R-HSA-8852135 1.193385e-05 4.923 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.412237e-05 4.850 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.412237e-05 4.850 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.412237e-05 4.850 0 0
Chromatin organization R-HSA-4839726 1.481637e-05 4.829 0 0
Regulation of CDH1 Function R-HSA-9764561 1.598759e-05 4.796 0 0
Interleukin-12 family signaling R-HSA-447115 1.646552e-05 4.783 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.727337e-05 4.763 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.870000e-05 4.728 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.401793e-05 4.619 0 0
MAP2K and MAPK activation R-HSA-5674135 2.533046e-05 4.596 0 0
Translation R-HSA-72766 2.279877e-05 4.642 0 0
Signal Transduction R-HSA-162582 2.372712e-05 4.625 1 0
Signaling by WNT R-HSA-195721 2.340564e-05 4.631 0 0
DNA Repair R-HSA-73894 2.930846e-05 4.533 0 0
EPH-Ephrin signaling R-HSA-2682334 3.372434e-05 4.472 1 0
HCMV Late Events R-HSA-9610379 3.638768e-05 4.439 0 0
Semaphorin interactions R-HSA-373755 3.921973e-05 4.406 1 0
Translation initiation complex formation R-HSA-72649 4.572806e-05 4.340 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 4.908106e-05 4.309 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 6.160364e-05 4.210 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 7.712904e-05 4.113 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.087422e-04 3.964 0 0
Signaling by NOTCH R-HSA-157118 1.243815e-04 3.905 0 0
G2/M Transition R-HSA-69275 1.305352e-04 3.884 0 0
Striated Muscle Contraction R-HSA-390522 1.332507e-04 3.875 0 0
Ub-specific processing proteases R-HSA-5689880 1.355931e-04 3.868 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.394995e-04 3.855 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.408153e-04 3.851 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.498626e-04 3.824 0 0
Apoptosis R-HSA-109581 1.500535e-04 3.824 0 0
Metalloprotease DUBs R-HSA-5689901 1.542457e-04 3.812 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.597996e-04 3.796 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.812003e-04 3.742 0 0
Formation of annular gap junctions R-HSA-196025 1.869271e-04 3.728 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.239308e-04 3.650 0 0
Gap junction trafficking R-HSA-190828 2.025656e-04 3.693 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.375276e-04 3.624 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.539138e-04 3.595 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.671910e-04 3.573 0 0
Gap junction degradation R-HSA-190873 2.780666e-04 3.556 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 2.780666e-04 3.556 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.932465e-04 3.533 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 3.033647e-04 3.518 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 3.554036e-04 3.449 0 0
Cytokine Signaling in Immune system R-HSA-1280215 3.568517e-04 3.448 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 3.994959e-04 3.398 0 0
Gap junction trafficking and regulation R-HSA-157858 4.136961e-04 3.383 0 0
mRNA Splicing R-HSA-72172 4.464781e-04 3.350 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 4.796463e-04 3.319 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 5.150955e-04 3.288 0 0
SARS-CoV-1-host interactions R-HSA-9692914 5.387371e-04 3.269 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 5.571961e-04 3.254 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 5.571961e-04 3.254 0 0
ESR-mediated signaling R-HSA-8939211 5.588296e-04 3.253 0 0
Maturation of protein E R-HSA-9683683 5.845790e-04 3.233 0 0
Maturation of protein E R-HSA-9694493 5.845790e-04 3.233 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 5.903985e-04 3.229 0 0
Selective autophagy R-HSA-9663891 7.690567e-04 3.114 0 0
RMTs methylate histone arginines R-HSA-3214858 8.698552e-04 3.061 0 0
Interferon Signaling R-HSA-913531 8.233029e-04 3.084 0 0
Hedgehog 'off' state R-HSA-5610787 8.755908e-04 3.058 0 0
Host Interactions of HIV factors R-HSA-162909 9.371136e-04 3.028 0 0
VLDLR internalisation and degradation R-HSA-8866427 1.007329e-03 2.997 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.015328e-03 2.993 0 0
PKR-mediated signaling R-HSA-9833482 1.043822e-03 2.981 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.043822e-03 2.981 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.056153e-03 2.976 0 0
FLT3 signaling in disease R-HSA-9682385 1.056153e-03 2.976 0 0
Programmed Cell Death R-HSA-5357801 1.093884e-03 2.961 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.258988e-03 2.900 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.296395e-03 2.887 1 1
Regulation of PTEN localization R-HSA-8948747 1.326988e-03 2.877 0 0
Deubiquitination R-HSA-5688426 1.410837e-03 2.851 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.519315e-03 2.818 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.519315e-03 2.818 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.557212e-03 2.808 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.607574e-03 2.794 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.649577e-03 2.783 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.683515e-03 2.774 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.713811e-03 2.766 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 1.833366e-03 2.737 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.833366e-03 2.737 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.873564e-03 2.727 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 1.873564e-03 2.727 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 1.873564e-03 2.727 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.873564e-03 2.727 0 0
Modulation by Mtb of host immune system R-HSA-9637628 1.873564e-03 2.727 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.873564e-03 2.727 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.946252e-03 2.711 0 0
mTORC1-mediated signalling R-HSA-166208 2.194268e-03 2.659 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 2.124682e-03 2.673 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 2.365421e-03 2.626 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.946252e-03 2.711 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 2.106262e-03 2.676 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 2.018993e-03 2.695 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.124682e-03 2.673 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.365421e-03 2.626 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 2.124682e-03 2.673 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.124682e-03 2.673 0 0
S Phase R-HSA-69242 2.414807e-03 2.617 0 0
MAPK family signaling cascades R-HSA-5683057 2.479199e-03 2.606 0 0
Glycolysis R-HSA-70171 2.489021e-03 2.604 0 0
Negative regulation of FLT3 R-HSA-9706369 2.644649e-03 2.578 0 0
Signaling by VEGF R-HSA-194138 2.799936e-03 2.553 1 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.833906e-03 2.548 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 2.911557e-03 2.536 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 2.911557e-03 2.536 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 3.073749e-03 2.512 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.073749e-03 2.512 0 0
Platelet degranulation R-HSA-114608 3.187857e-03 2.497 0 0
Signaling by Interleukins R-HSA-449147 3.226941e-03 2.491 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 3.251075e-03 2.488 0 0
Josephin domain DUBs R-HSA-5689877 3.399468e-03 2.469 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 3.399468e-03 2.469 0 0
Pexophagy R-HSA-9664873 3.399468e-03 2.469 0 0
Dual Incision in GG-NER R-HSA-5696400 3.414125e-03 2.467 0 0
Nuclear import of Rev protein R-HSA-180746 3.414125e-03 2.467 0 0
Autophagy R-HSA-9612973 3.848117e-03 2.415 0 0
Nucleotide Excision Repair R-HSA-5696398 3.854821e-03 2.414 0 0
Oncogene Induced Senescence R-HSA-2559585 3.886633e-03 2.410 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 3.951638e-03 2.403 0 0
Infectious disease R-HSA-5663205 4.019714e-03 2.396 1 0
HIV Life Cycle R-HSA-162587 4.068520e-03 2.391 0 0
Signaling by EGFR in Cancer R-HSA-1643713 4.192828e-03 2.377 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 4.221275e-03 2.375 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.221275e-03 2.375 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 4.444033e-03 2.352 0 0
Ephrin signaling R-HSA-3928664 4.753976e-03 2.323 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 4.753976e-03 2.323 0 0
Transport of connexons to the plasma membrane R-HSA-190872 4.753976e-03 2.323 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 4.829860e-03 2.316 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 4.978653e-03 2.303 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 5.016796e-03 2.300 0 0
Kinesins R-HSA-983189 5.119066e-03 2.291 0 0
Switching of origins to a post-replicative state R-HSA-69052 5.252749e-03 2.280 0 0
Late endosomal microautophagy R-HSA-9615710 6.399449e-03 2.194 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 6.698128e-03 2.174 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 6.698128e-03 2.174 0 0
Chaperonin-mediated protein folding R-HSA-390466 6.033980e-03 2.219 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 7.029231e-03 2.153 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.605941e-03 2.251 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 6.694053e-03 2.174 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 7.000462e-03 2.155 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 6.446635e-03 2.191 0 0
HIV Infection R-HSA-162906 6.793912e-03 2.168 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 7.293896e-03 2.137 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 6.286659e-03 2.202 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 7.029231e-03 2.153 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 7.029231e-03 2.153 0 0
UCH proteinases R-HSA-5689603 6.697173e-03 2.174 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 6.185138e-03 2.209 0 0
Negative regulation of MET activity R-HSA-6807004 6.694053e-03 2.174 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 5.605941e-03 2.251 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 7.000462e-03 2.155 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 7.000462e-03 2.155 0 0
MHC class II antigen presentation R-HSA-2132295 5.682675e-03 2.245 0 0
Regulation of signaling by CBL R-HSA-912631 5.665641e-03 2.247 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 6.694053e-03 2.174 1 1
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.605941e-03 2.251 0 0
NF-kB is activated and signals survival R-HSA-209560 5.605941e-03 2.251 0 0
IRAK1 recruits IKK complex R-HSA-937039 7.000462e-03 2.155 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 7.000462e-03 2.155 0 0
SARS-CoV-2-host interactions R-HSA-9705683 7.091194e-03 2.149 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 5.488852e-03 2.261 0 0
p75NTR recruits signalling complexes R-HSA-209543 7.000462e-03 2.155 0 0
Orc1 removal from chromatin R-HSA-68949 7.738343e-03 2.111 0 0
mRNA 3'-end processing R-HSA-72187 7.738343e-03 2.111 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 7.834907e-03 2.106 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 7.846454e-03 2.105 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.846454e-03 2.105 0 0
Response of endothelial cells to shear stress R-HSA-9860931 8.576466e-03 2.067 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 8.606626e-03 2.065 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 8.606626e-03 2.065 0 0
AURKA Activation by TPX2 R-HSA-8854518 8.626397e-03 2.064 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 8.706727e-03 2.060 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 8.706727e-03 2.060 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 8.706727e-03 2.060 0 0
Breakdown of the nuclear lamina R-HSA-352238 8.820728e-03 2.054 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 8.872391e-03 2.052 0 0
Immune System R-HSA-168256 9.051950e-03 2.043 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 9.129870e-03 2.040 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 9.129870e-03 2.040 0 0
Protein folding R-HSA-391251 9.220200e-03 2.035 0 0
Diseases of mitotic cell cycle R-HSA-9675126 9.348014e-03 2.029 0 0
Glucose metabolism R-HSA-70326 9.436645e-03 2.025 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 9.618920e-03 2.017 1 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.043627e-02 1.981 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.043627e-02 1.981 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.043627e-02 1.981 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.043627e-02 1.981 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.051644e-02 1.978 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 1.055108e-02 1.977 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.064194e-02 1.973 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.064194e-02 1.973 0 0
Synthesis of DNA R-HSA-69239 1.098662e-02 1.959 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.108049e-02 1.955 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.166373e-02 1.933 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.174916e-02 1.930 1 1
Cyclin D associated events in G1 R-HSA-69231 1.174916e-02 1.930 0 0
G1 Phase R-HSA-69236 1.174916e-02 1.930 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.176521e-02 1.929 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.176521e-02 1.929 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.211656e-02 1.917 0 0
Translesion synthesis by REV1 R-HSA-110312 1.250014e-02 1.903 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.250014e-02 1.903 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 1.250014e-02 1.903 0 0
p75NTR signals via NF-kB R-HSA-193639 1.250014e-02 1.903 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.521134e-02 1.818 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.521134e-02 1.818 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.521134e-02 1.818 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.521134e-02 1.818 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.521134e-02 1.818 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.521134e-02 1.818 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.521134e-02 1.818 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.521134e-02 1.818 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.521134e-02 1.818 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.521134e-02 1.818 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.521134e-02 1.818 0 0
Translesion synthesis by POLI R-HSA-5656121 1.480791e-02 1.830 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 1.736810e-02 1.760 0 0
Translesion synthesis by POLK R-HSA-5655862 1.736810e-02 1.760 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.463775e-02 1.835 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.416282e-02 1.849 0 0
Dual incision in TC-NER R-HSA-6782135 1.310355e-02 1.883 0 0
snRNP Assembly R-HSA-191859 1.421068e-02 1.847 0 0
Metabolism of non-coding RNA R-HSA-194441 1.421068e-02 1.847 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.473799e-02 1.832 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.695909e-02 1.771 0 0
Centrosome maturation R-HSA-380287 1.695909e-02 1.771 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.549389e-02 1.810 0 0
DNA Damage Bypass R-HSA-73893 1.841826e-02 1.735 0 0
Unwinding of DNA R-HSA-176974 1.900322e-02 1.721 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.662674e-02 1.779 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.642296e-02 1.785 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.841826e-02 1.735 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.841826e-02 1.735 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.691148e-02 1.772 0 0
tRNA processing in the nucleus R-HSA-6784531 1.793981e-02 1.746 0 0
G1/S Transition R-HSA-69206 1.550348e-02 1.810 0 0
Calmodulin induced events R-HSA-111933 1.623024e-02 1.790 0 0
CaM pathway R-HSA-111997 1.623024e-02 1.790 0 0
Signaling by ERBB2 R-HSA-1227986 1.538438e-02 1.813 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.793844e-02 1.746 0 0
Post NMDA receptor activation events R-HSA-438064 1.573766e-02 1.803 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.513914e-02 1.820 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 1.773862e-02 1.751 0 0
Signaling by Hedgehog R-HSA-5358351 1.527549e-02 1.816 0 0
Macroautophagy R-HSA-1632852 1.767031e-02 1.753 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.736810e-02 1.760 0 0
RET signaling R-HSA-8853659 1.623024e-02 1.790 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.383248e-02 1.859 0 0
Neurodegenerative Diseases R-HSA-8863678 1.383248e-02 1.859 0 0
Disease R-HSA-1643685 1.474140e-02 1.831 1 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 1.736810e-02 1.760 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 1.480791e-02 1.830 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.570468e-02 1.804 1 0
Regulation of BACH1 activity R-HSA-9708530 1.480791e-02 1.830 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.976589e-02 1.704 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.993937e-02 1.700 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.993937e-02 1.700 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.993937e-02 1.700 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 2.018810e-02 1.695 0 0
Glycogen storage diseases R-HSA-3229121 2.018810e-02 1.695 0 0
Cilium Assembly R-HSA-5617833 2.028104e-02 1.693 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.171600e-02 1.663 0 0
Plasma lipoprotein clearance R-HSA-8964043 2.171600e-02 1.663 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.231160e-02 1.651 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.231160e-02 1.651 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 2.271690e-02 1.644 0 0
Adaptive Immune System R-HSA-1280218 2.279173e-02 1.642 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.327417e-02 1.633 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 2.336206e-02 1.631 0 0
2-LTR circle formation R-HSA-164843 2.336206e-02 1.631 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 2.349940e-02 1.629 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.356778e-02 1.628 0 0
Signaling by MET R-HSA-6806834 2.356778e-02 1.628 0 0
Signaling by FGFR2 R-HSA-5654738 2.356778e-02 1.628 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.379197e-02 1.624 0 0
Termination of translesion DNA synthesis R-HSA-5656169 2.485958e-02 1.605 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.485958e-02 1.605 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 2.538809e-02 1.595 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.538809e-02 1.595 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.599682e-02 1.585 0 0
Translesion Synthesis by POLH R-HSA-110320 2.663143e-02 1.575 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 2.663143e-02 1.575 0 0
Rap1 signalling R-HSA-392517 2.663143e-02 1.575 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.758713e-02 1.559 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.758713e-02 1.559 0 0
Activation of the pre-replicative complex R-HSA-68962 2.758713e-02 1.559 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 2.947138e-02 1.531 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 2.947138e-02 1.531 0 0
Signaling by NOTCH3 R-HSA-9012852 2.947138e-02 1.531 0 0
Signal transduction by L1 R-HSA-445144 3.026392e-02 1.519 0 0
Protein hydroxylation R-HSA-9629569 3.026392e-02 1.519 0 0
Glycogen synthesis R-HSA-3322077 3.026392e-02 1.519 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 3.049765e-02 1.516 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 3.049765e-02 1.516 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 3.049765e-02 1.516 0 0
EGFR downregulation R-HSA-182971 3.049765e-02 1.516 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 3.049765e-02 1.516 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 3.049765e-02 1.516 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.053119e-02 1.515 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.080417e-02 1.511 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 3.080417e-02 1.511 0 0
MTOR signalling R-HSA-165159 3.080417e-02 1.511 0 0
Ca-dependent events R-HSA-111996 3.080417e-02 1.511 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.080417e-02 1.511 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 3.167006e-02 1.499 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.167006e-02 1.499 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 3.221650e-02 1.492 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 3.283043e-02 1.484 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 3.325422e-02 1.478 0 0
Regulation of mitotic cell cycle R-HSA-453276 3.325422e-02 1.478 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 3.325422e-02 1.478 0 0
Signaling by FGFR4 R-HSA-5654743 3.341166e-02 1.476 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 3.341166e-02 1.476 0 0
Activation of RAC1 R-HSA-428540 3.356321e-02 1.474 0 0
Integration of provirus R-HSA-162592 3.356321e-02 1.474 0 0
DNA strand elongation R-HSA-69190 3.359409e-02 1.474 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 3.359409e-02 1.474 0 0
Early Phase of HIV Life Cycle R-HSA-162594 3.417460e-02 1.466 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 3.417460e-02 1.466 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 3.417460e-02 1.466 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.432979e-02 1.464 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.537607e-02 1.451 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.615798e-02 1.442 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.687896e-02 1.433 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.687896e-02 1.433 0 0
G-protein beta:gamma signalling R-HSA-397795 3.687896e-02 1.433 0 0
Regulation of necroptotic cell death R-HSA-5675482 3.687896e-02 1.433 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 3.687896e-02 1.433 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 3.687896e-02 1.433 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 3.758757e-02 1.425 0 0
Gene expression (Transcription) R-HSA-74160 3.828307e-02 1.417 0 0
Assembly Of The HIV Virion R-HSA-175474 3.836535e-02 1.416 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.836535e-02 1.416 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 3.836535e-02 1.416 0 0
DAG and IP3 signaling R-HSA-1489509 3.904507e-02 1.408 0 0
Signaling by FGFR3 R-HSA-5654741 3.904507e-02 1.408 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.909239e-02 1.408 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 3.909239e-02 1.408 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 3.939681e-02 1.405 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 4.035432e-02 1.394 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 4.035432e-02 1.394 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 4.035432e-02 1.394 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 4.035432e-02 1.394 0 0
Clathrin-mediated endocytosis R-HSA-8856828 4.071412e-02 1.390 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 4.089896e-02 1.388 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 4.198398e-02 1.377 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 4.207464e-02 1.376 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 4.207464e-02 1.376 0 0
IRS activation R-HSA-74713 4.255155e-02 1.371 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 4.283710e-02 1.368 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 4.283710e-02 1.368 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 4.283710e-02 1.368 0 0
RAF activation R-HSA-5673000 4.402181e-02 1.356 0 0
NOD1/2 Signaling Pathway R-HSA-168638 4.402181e-02 1.356 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 4.402181e-02 1.356 0 0
Gap junction assembly R-HSA-190861 4.402181e-02 1.356 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 4.417662e-02 1.355 0 0
Viral Messenger RNA Synthesis R-HSA-168325 4.430438e-02 1.354 0 0
PLC beta mediated events R-HSA-112043 4.430438e-02 1.354 0 0
MAP kinase activation R-HSA-450294 4.430438e-02 1.354 0 0
Developmental Cell Lineages R-HSA-9734767 4.476087e-02 1.349 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 4.524815e-02 1.344 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 4.533073e-02 1.344 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 4.570858e-02 1.340 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 4.570858e-02 1.340 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 4.570858e-02 1.340 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 4.570858e-02 1.340 0 0
Membrane Trafficking R-HSA-199991 4.577928e-02 1.339 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 4.716972e-02 1.326 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 4.788259e-02 1.320 0 0
Regulation of Apoptosis R-HSA-169911 4.788259e-02 1.320 0 0
GPER1 signaling R-HSA-9634597 4.856685e-02 1.314 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.015069e-02 1.300 0 0
Regulation of TP53 Degradation R-HSA-6804757 5.193742e-02 1.285 0 0
Degradation of CDH1 R-HSA-9766229 5.203174e-02 1.284 0 0
HDL assembly R-HSA-8963896 5.248764e-02 1.280 0 0
Deadenylation of mRNA R-HSA-429947 5.262232e-02 1.279 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 5.324879e-02 1.274 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 5.393814e-02 1.268 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.393814e-02 1.268 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 5.393814e-02 1.268 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 5.393814e-02 1.268 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 8.860921e-02 1.053 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 8.860921e-02 1.053 0 0
Diseases of Telomere Maintenance R-HSA-9673013 8.860921e-02 1.053 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 8.860921e-02 1.053 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 8.860921e-02 1.053 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 8.860921e-02 1.053 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 8.860921e-02 1.053 0 0
Autointegration results in viral DNA circles R-HSA-177539 6.625997e-02 1.179 0 0
SOS-mediated signalling R-HSA-112412 7.940909e-02 1.100 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 7.940909e-02 1.100 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 9.328541e-02 1.030 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 9.328541e-02 1.030 0 0
ALK mutants bind TKIs R-HSA-9700645 1.077962e-01 0.967 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 5.972111e-02 1.224 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 6.739440e-02 1.171 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 6.739440e-02 1.171 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 7.549150e-02 1.122 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 8.399517e-02 1.076 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.288722e-02 1.032 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 5.793294e-02 1.237 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 5.793294e-02 1.237 0 0
E2F mediated regulation of DNA replication R-HSA-113510 1.021487e-01 0.991 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 6.937673e-02 1.159 0 0
Interaction between L1 and Ankyrins R-HSA-445095 6.937673e-02 1.159 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 6.937673e-02 1.159 1 1
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 8.189042e-02 1.087 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 6.526732e-02 1.185 0 0
Neutrophil degranulation R-HSA-6798695 6.212118e-02 1.207 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 7.511904e-02 1.124 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 6.351891e-02 1.197 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 7.549150e-02 1.122 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 7.511904e-02 1.124 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 8.228557e-02 1.085 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 1.030301e-01 0.987 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.618662e-02 1.250 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 7.511904e-02 1.124 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.708261e-02 1.013 0 0
Inhibition of PKR R-HSA-169131 8.860921e-02 1.053 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 9.288722e-02 1.032 0 0
PKA activation R-HSA-163615 9.288722e-02 1.032 0 0
PKA activation in glucagon signalling R-HSA-164378 9.288722e-02 1.032 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.288722e-02 1.032 0 0
Budding and maturation of HIV virion R-HSA-162588 9.543246e-02 1.020 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 7.156773e-02 1.145 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.030301e-01 0.987 0 0
Signaling by EGFR R-HSA-177929 8.041441e-02 1.095 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 7.431348e-02 1.129 0 0
COPI-mediated anterograde transport R-HSA-6807878 6.509805e-02 1.186 0 0
Platelet activation, signaling and aggregation R-HSA-76002 6.091754e-02 1.215 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 9.288722e-02 1.032 0 0
Protein methylation R-HSA-8876725 5.972111e-02 1.224 0 0
Signaling by Hippo R-HSA-2028269 8.399517e-02 1.076 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.077962e-01 0.967 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.091541e-01 0.962 0 0
CHL1 interactions R-HSA-447041 7.940909e-02 1.100 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.077962e-01 0.967 0 0
Cellular response to hypoxia R-HSA-1234174 5.646300e-02 1.248 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 1.030301e-01 0.987 0 0
Regulation of PTEN gene transcription R-HSA-8943724 9.984849e-02 1.001 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.041441e-02 1.095 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 6.739440e-02 1.171 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.090185e-01 0.962 0 0
Opioid Signalling R-HSA-111885 9.139650e-02 1.039 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 6.625997e-02 1.179 0 0
TNF signaling R-HSA-75893 8.041441e-02 1.095 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 6.063009e-02 1.217 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.045607e-01 0.981 0 0
G-protein mediated events R-HSA-112040 6.324689e-02 1.199 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 6.808784e-02 1.167 0 0
Interleukin-17 signaling R-HSA-448424 7.431348e-02 1.129 0 0
Signaling by FGFR R-HSA-190236 7.116234e-02 1.148 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 7.940909e-02 1.100 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.739440e-02 1.171 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 7.511904e-02 1.124 0 0
Signaling by FGFR1 R-HSA-5654736 8.041441e-02 1.095 0 0
PCP/CE pathway R-HSA-4086400 1.090185e-01 0.962 0 0
Ion homeostasis R-HSA-5578775 8.041441e-02 1.095 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 9.522587e-02 1.021 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 6.526732e-02 1.185 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 6.937673e-02 1.159 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 8.828481e-02 1.054 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 8.505698e-02 1.070 0 0
Signaling by NTRKs R-HSA-166520 9.043395e-02 1.044 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.021487e-01 0.991 0 0
Nef and signal transduction R-HSA-164944 6.625997e-02 1.179 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 9.328541e-02 1.030 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 1.077962e-01 0.967 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 5.972111e-02 1.224 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 6.509805e-02 1.186 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 7.431348e-02 1.129 0 0
Signaling by Nuclear Receptors R-HSA-9006931 5.863619e-02 1.232 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.022800e-01 0.990 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 1.077962e-01 0.967 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 8.041441e-02 1.095 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 1.080137e-01 0.967 0 0
Suppression of phagosomal maturation R-HSA-9637687 6.351891e-02 1.197 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.131490e-02 1.039 0 0
SARS-CoV Infections R-HSA-9679506 9.412418e-02 1.026 1 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 7.550220e-02 1.122 0 0
SARS-CoV-2 Infection R-HSA-9694516 6.487014e-02 1.188 0 0
Translation of Structural Proteins R-HSA-9683701 8.033058e-02 1.095 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 8.189042e-02 1.087 0 0
FLT3 Signaling R-HSA-9607240 7.511904e-02 1.124 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.099520e-01 0.959 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.099520e-01 0.959 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.117599e-01 0.952 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.117599e-01 0.952 0 0
Nephrin family interactions R-HSA-373753 1.117599e-01 0.952 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 1.154510e-01 0.938 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 1.154510e-01 0.938 0 0
Vpu mediated degradation of CD4 R-HSA-180534 1.175603e-01 0.930 0 0
TCR signaling R-HSA-202403 1.188517e-01 0.925 0 0
RNA Polymerase II Transcription R-HSA-73857 1.202026e-01 0.920 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 1.215268e-01 0.915 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.217010e-01 0.915 0 0
Intraflagellar transport R-HSA-5620924 1.219169e-01 0.914 0 0
Gluconeogenesis R-HSA-70263 1.219169e-01 0.914 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.228556e-01 0.911 0 0
PI3K/AKT activation R-HSA-198203 1.228556e-01 0.911 0 0
Signal attenuation R-HSA-74749 1.228556e-01 0.911 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.228556e-01 0.911 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 1.228556e-01 0.911 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.228556e-01 0.911 0 0
Signaling by Leptin R-HSA-2586552 1.228556e-01 0.911 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.246666e-01 0.904 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 1.253905e-01 0.902 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 1.253905e-01 0.902 0 0
Calnexin/calreticulin cycle R-HSA-901042 1.253905e-01 0.902 0 0
Signaling by NOTCH2 R-HSA-1980145 1.253905e-01 0.902 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.253905e-01 0.902 0 0
Mitophagy R-HSA-5205647 1.253905e-01 0.902 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 1.299282e-01 0.886 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 1.299282e-01 0.886 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 1.299282e-01 0.886 0 0
NTRK3 as a dependence receptor R-HSA-9603505 1.299282e-01 0.886 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.319515e-01 0.880 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 1.334343e-01 0.875 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 1.334343e-01 0.875 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.334343e-01 0.875 0 0
Metabolism of proteins R-HSA-392499 1.358483e-01 0.867 0 0
PECAM1 interactions R-HSA-210990 1.383841e-01 0.859 0 0
Regulation of insulin secretion R-HSA-422356 1.386212e-01 0.858 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.391795e-01 0.856 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 1.416832e-01 0.849 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 1.416832e-01 0.849 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 1.422869e-01 0.847 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.422869e-01 0.847 0 0
FGFR2 alternative splicing R-HSA-6803529 1.424911e-01 0.846 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.436167e-01 0.843 0 0
Regulated Necrosis R-HSA-5218859 1.453157e-01 0.838 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.453157e-01 0.838 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.493859e-01 0.826 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 1.493859e-01 0.826 0 0
Degradation of DVL R-HSA-4641258 1.501282e-01 0.824 0 0
Degradation of AXIN R-HSA-4641257 1.501282e-01 0.824 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 1.501282e-01 0.824 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.515731e-01 0.819 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 1.532991e-01 0.814 0 0
Syndecan interactions R-HSA-3000170 1.532991e-01 0.814 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.532991e-01 0.814 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 1.543086e-01 0.812 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 1.543086e-01 0.812 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.543086e-01 0.812 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.566312e-01 0.805 0 0
MET promotes cell motility R-HSA-8875878 1.587604e-01 0.799 0 0
Plasma lipoprotein assembly R-HSA-8963898 1.643551e-01 0.784 0 0
Hedgehog 'on' state R-HSA-5632684 1.644389e-01 0.784 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.674424e-01 0.776 0 0
Stabilization of p53 R-HSA-69541 1.675705e-01 0.776 0 0
RAS processing R-HSA-9648002 1.675705e-01 0.776 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.693764e-01 0.771 0 0
Regulation of cortical dendrite branching R-HSA-8985801 1.693764e-01 0.771 0 0
Potassium transport channels R-HSA-1296067 1.693764e-01 0.771 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 1.693764e-01 0.771 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 1.693764e-01 0.771 0 0
Defective DHDDS causes RP59 R-HSA-4755609 1.693764e-01 0.771 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.693764e-01 0.771 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 1.693764e-01 0.771 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 1.693764e-01 0.771 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.698818e-01 0.770 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.705613e-01 0.768 0 0
Leading Strand Synthesis R-HSA-69109 1.705613e-01 0.768 0 0
Polymerase switching R-HSA-69091 1.705613e-01 0.768 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.705613e-01 0.768 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.705613e-01 0.768 0 0
ER-Phagosome pathway R-HSA-1236974 1.743237e-01 0.759 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 1.765491e-01 0.753 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 1.765491e-01 0.753 0 0
Generation of second messenger molecules R-HSA-202433 1.765491e-01 0.753 0 0
Glycogen metabolism R-HSA-8982491 1.765491e-01 0.753 0 0
Signaling by FGFR in disease R-HSA-1226099 1.845659e-01 0.734 0 0
Signaling by NOTCH4 R-HSA-9013694 1.845659e-01 0.734 0 0
Signaling by ERBB4 R-HSA-1236394 1.845659e-01 0.734 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 1.856867e-01 0.731 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.856867e-01 0.731 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 1.856867e-01 0.731 0 0
Frs2-mediated activation R-HSA-170968 1.870798e-01 0.728 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 1.870798e-01 0.728 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.870798e-01 0.728 0 0
Cellular response to chemical stress R-HSA-9711123 1.895788e-01 0.722 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 1.914819e-01 0.718 0 0
IRE1alpha activates chaperones R-HSA-381070 1.928320e-01 0.715 0 0
PTEN Regulation R-HSA-6807070 1.933613e-01 0.714 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.933613e-01 0.714 0 0
Degradation of CRY and PER proteins R-HSA-9932298 1.949739e-01 0.710 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.949739e-01 0.710 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.957420e-01 0.708 0 0
Stimuli-sensing channels R-HSA-2672351 1.981431e-01 0.703 0 0
Cristae formation R-HSA-8949613 1.988095e-01 0.702 0 0
Peroxisomal protein import R-HSA-9033241 2.028847e-01 0.693 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.038067e-01 0.691 0 0
Removal of the Flap Intermediate R-HSA-69166 2.038067e-01 0.691 0 0
Retrograde neurotrophin signalling R-HSA-177504 2.038067e-01 0.691 0 0
Regulation of KIT signaling R-HSA-1433559 2.038067e-01 0.691 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.044008e-01 0.690 0 0
Translation of Structural Proteins R-HSA-9694635 2.056022e-01 0.687 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 2.070383e-01 0.684 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 2.070383e-01 0.684 0 0
MET activates PTPN11 R-HSA-8865999 2.070383e-01 0.684 0 0
MET interacts with TNS proteins R-HSA-8875513 2.070383e-01 0.684 0 0
Histamine receptors R-HSA-390650 2.070383e-01 0.684 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 2.106571e-01 0.676 0 0
G alpha (12/13) signalling events R-HSA-416482 2.127991e-01 0.672 1 1
Hh mutants abrogate ligand secretion R-HSA-5387390 2.139580e-01 0.670 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 2.186570e-01 0.660 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 2.192294e-01 0.659 0 0
Aquaporin-mediated transport R-HSA-445717 2.192294e-01 0.659 0 0
Sensory processing of sound R-HSA-9659379 2.200820e-01 0.657 0 0
Erythropoietin activates RAS R-HSA-9027284 2.206894e-01 0.656 0 0
G beta:gamma signalling through BTK R-HSA-8964315 2.206894e-01 0.656 0 0
Processive synthesis on the lagging strand R-HSA-69183 2.206894e-01 0.656 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 2.206894e-01 0.656 0 0
Signaling by Erythropoietin R-HSA-9006335 2.226541e-01 0.652 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.226541e-01 0.652 0 0
DARPP-32 events R-HSA-180024 2.226541e-01 0.652 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.226541e-01 0.652 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.237921e-01 0.650 0 0
Fanconi Anemia Pathway R-HSA-6783310 2.334245e-01 0.632 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 2.334245e-01 0.632 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 2.334245e-01 0.632 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 2.334245e-01 0.632 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 2.334245e-01 0.632 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 2.334245e-01 0.632 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.347819e-01 0.629 0 0
Signaling by PTK6 R-HSA-8848021 2.359611e-01 0.627 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.359611e-01 0.627 0 0
Phosphorylation of the APC/C R-HSA-176412 2.376793e-01 0.624 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 2.376793e-01 0.624 0 0
Prolonged ERK activation events R-HSA-169893 2.376793e-01 0.624 0 0
Hemostasis R-HSA-109582 2.385551e-01 0.622 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 2.429948e-01 0.614 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 2.429948e-01 0.614 0 0
Regulation of pyruvate metabolism R-HSA-9861718 2.433147e-01 0.614 0 0
Generic Transcription Pathway R-HSA-212436 2.449667e-01 0.611 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.456321e-01 0.610 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.456321e-01 0.610 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.456321e-01 0.610 0 0
Trafficking of AMPA receptors R-HSA-399719 2.470225e-01 0.607 0 0
Vesicle-mediated transport R-HSA-5653656 2.472244e-01 0.607 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 2.532970e-01 0.596 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.547322e-01 0.594 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 2.547322e-01 0.594 0 0
Disorders of Developmental Biology R-HSA-9675151 2.547322e-01 0.594 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 2.547322e-01 0.594 0 0
Inwardly rectifying K+ channels R-HSA-1296065 2.593583e-01 0.586 0 0
G0 and Early G1 R-HSA-1538133 2.593583e-01 0.586 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 2.713650e-01 0.566 0 0
Integrin signaling R-HSA-354192 2.717724e-01 0.566 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.717724e-01 0.566 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.717724e-01 0.566 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.717724e-01 0.566 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.718075e-01 0.566 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.718075e-01 0.566 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.718075e-01 0.566 0 0
Specification of primordial germ cells R-HSA-9827857 2.718075e-01 0.566 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 2.735004e-01 0.563 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.735004e-01 0.563 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.773229e-01 0.557 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.773229e-01 0.557 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.773229e-01 0.557 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.773229e-01 0.557 0 0
Reelin signalling pathway R-HSA-8866376 2.773229e-01 0.557 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 2.773229e-01 0.557 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 2.792103e-01 0.554 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 2.792103e-01 0.554 0 0
Death Receptor Signaling R-HSA-73887 2.800780e-01 0.553 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.809632e-01 0.551 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.809632e-01 0.551 0 0
Azathioprine ADME R-HSA-9748787 2.837032e-01 0.547 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.837032e-01 0.547 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.842484e-01 0.546 0 0
Hedgehog ligand biogenesis R-HSA-5358346 2.939614e-01 0.532 0 0
RSV-host interactions R-HSA-9833110 2.950449e-01 0.530 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 2.967705e-01 0.528 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 2.968924e-01 0.527 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 2.991047e-01 0.524 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 2.991047e-01 0.524 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 3.022852e-01 0.520 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.042663e-01 0.517 0 0
Neurexins and neuroligins R-HSA-6794361 3.042663e-01 0.517 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 3.058805e-01 0.514 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 3.058805e-01 0.514 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 3.058805e-01 0.514 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 3.058805e-01 0.514 0 0
Maturation of nucleoprotein R-HSA-9694631 3.058805e-01 0.514 0 0
Signalling to ERKs R-HSA-187687 3.093235e-01 0.510 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 3.100963e-01 0.509 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 3.100963e-01 0.509 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 3.100963e-01 0.509 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 3.100963e-01 0.509 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 3.100963e-01 0.509 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 3.100963e-01 0.509 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 3.100963e-01 0.509 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 3.100963e-01 0.509 0 0
Downstream TCR signaling R-HSA-202424 3.127291e-01 0.505 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 3.143090e-01 0.503 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 3.146093e-01 0.502 0 0
Regulation of PTEN stability and activity R-HSA-8948751 3.146093e-01 0.502 0 0
G1/S-Specific Transcription R-HSA-69205 3.218928e-01 0.492 0 0
Triglyceride catabolism R-HSA-163560 3.218928e-01 0.492 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 3.228138e-01 0.491 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 3.228138e-01 0.491 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 3.228138e-01 0.491 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 3.228138e-01 0.491 0 0
Formation of definitive endoderm R-HSA-9823730 3.228138e-01 0.491 0 0
Ca2+ pathway R-HSA-4086398 3.237867e-01 0.490 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.242111e-01 0.489 0 0
Antigen processing-Cross presentation R-HSA-1236975 3.242111e-01 0.489 0 0
Neddylation R-HSA-8951664 3.304293e-01 0.481 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 3.315782e-01 0.479 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 3.369218e-01 0.472 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.389695e-01 0.470 0 0
MyD88-independent TLR4 cascade R-HSA-166166 3.389695e-01 0.470 0 0
Lagging Strand Synthesis R-HSA-69186 3.396403e-01 0.469 0 0
G-protein activation R-HSA-202040 3.396403e-01 0.469 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 3.396403e-01 0.469 0 0
Basigin interactions R-HSA-210991 3.396403e-01 0.469 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.396403e-01 0.469 0 0
Signaling by LTK in cancer R-HSA-9842640 3.413853e-01 0.467 0 0
Erythropoietin activates STAT5 R-HSA-9027283 3.413853e-01 0.467 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.413853e-01 0.467 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.413853e-01 0.467 0 0
CREB phosphorylation R-HSA-199920 3.413853e-01 0.467 0 0
Iron uptake and transport R-HSA-917937 3.418639e-01 0.466 0 0
NRAGE signals death through JNK R-HSA-193648 3.457839e-01 0.461 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 3.470252e-01 0.460 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 3.470252e-01 0.460 0 0
Signaling by NOTCH1 R-HSA-1980143 3.509307e-01 0.455 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.563349e-01 0.448 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.563349e-01 0.448 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.563349e-01 0.448 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 3.563349e-01 0.448 0 0
Ribavirin ADME R-HSA-9755088 3.563349e-01 0.448 0 0
ER to Golgi Anterograde Transport R-HSA-199977 3.590527e-01 0.445 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.595623e-01 0.444 0 0
Signaling by ALK R-HSA-201556 3.595623e-01 0.444 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 3.595623e-01 0.444 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 3.612595e-01 0.442 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 3.655161e-01 0.437 0 0
Integrin cell surface interactions R-HSA-216083 3.690946e-01 0.433 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 3.712571e-01 0.430 0 0
IFNG signaling activates MAPKs R-HSA-9732724 3.712571e-01 0.430 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.712571e-01 0.430 0 0
Disinhibition of SNARE formation R-HSA-114516 3.712571e-01 0.430 0 0
DAG1 core M1 glycosylations R-HSA-8932506 3.712571e-01 0.430 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 3.712571e-01 0.430 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 3.712571e-01 0.430 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.712571e-01 0.430 0 0
VLDL clearance R-HSA-8964046 3.712571e-01 0.430 0 0
LDL clearance R-HSA-8964038 3.728751e-01 0.428 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.728751e-01 0.428 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.770115e-01 0.424 0 0
MITF-M-dependent gene expression R-HSA-9856651 3.784778e-01 0.422 0 0
Circadian clock R-HSA-9909396 3.811682e-01 0.419 0 0
tRNA processing R-HSA-72306 3.818068e-01 0.418 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.836628e-01 0.416 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.857989e-01 0.414 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 3.873979e-01 0.412 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 3.873979e-01 0.412 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 3.873979e-01 0.412 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 3.873979e-01 0.412 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 3.873979e-01 0.412 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 3.892406e-01 0.410 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 3.892406e-01 0.410 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 3.892406e-01 0.410 0 0
Growth hormone receptor signaling R-HSA-982772 3.892406e-01 0.410 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.918875e-01 0.407 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 3.963412e-01 0.402 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.977289e-01 0.400 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 3.977613e-01 0.400 0 0
Protein localization R-HSA-9609507 3.979793e-01 0.400 0 0
Type I hemidesmosome assembly R-HSA-446107 3.997758e-01 0.398 0 0
DAG1 core M2 glycosylations R-HSA-8932504 3.997758e-01 0.398 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 3.997758e-01 0.398 0 0
MET receptor recycling R-HSA-8875656 3.997758e-01 0.398 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 3.997758e-01 0.398 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.997758e-01 0.398 0 0
Fructose biosynthesis R-HSA-5652227 3.997758e-01 0.398 0 0
Sodium/Proton exchangers R-HSA-425986 3.997758e-01 0.398 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.997758e-01 0.398 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 4.054131e-01 0.392 0 0
Thromboxane signalling through TP receptor R-HSA-428930 4.054131e-01 0.392 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 4.054131e-01 0.392 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 4.054131e-01 0.392 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.054131e-01 0.392 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 4.054131e-01 0.392 0 0
Mitochondrial biogenesis R-HSA-1592230 4.061036e-01 0.391 0 0
Integration of energy metabolism R-HSA-163685 4.158786e-01 0.381 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 4.183930e-01 0.378 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 4.213766e-01 0.375 0 0
G protein gated Potassium channels R-HSA-1296059 4.213766e-01 0.375 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 4.213766e-01 0.375 0 0
Long-term potentiation R-HSA-9620244 4.213766e-01 0.375 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 4.213766e-01 0.375 0 0
HDMs demethylate histones R-HSA-3214842 4.213766e-01 0.375 0 0
Hyaluronan degradation R-HSA-2160916 4.213766e-01 0.375 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 4.213766e-01 0.375 0 0
Interleukin-7 signaling R-HSA-1266695 4.213766e-01 0.375 0 0
Lipophagy R-HSA-9613354 4.270025e-01 0.370 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.270025e-01 0.370 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 4.270025e-01 0.370 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 4.270025e-01 0.370 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.270025e-01 0.370 0 0
ARMS-mediated activation R-HSA-170984 4.270025e-01 0.370 0 0
Regulation of signaling by NODAL R-HSA-1433617 4.270025e-01 0.370 0 0
GP1b-IX-V activation signalling R-HSA-430116 4.270025e-01 0.370 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.270025e-01 0.370 0 0
IGF1R signaling cascade R-HSA-2428924 4.286488e-01 0.368 0 0
Protein-protein interactions at synapses R-HSA-6794362 4.324738e-01 0.364 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 4.371167e-01 0.359 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 4.371167e-01 0.359 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.371167e-01 0.359 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 4.371167e-01 0.359 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 4.388568e-01 0.358 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 4.414426e-01 0.355 0 0
Signaling by TGFB family members R-HSA-9006936 4.435062e-01 0.353 0 0
Regulation of TP53 Activity R-HSA-5633007 4.435062e-01 0.353 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.457221e-01 0.351 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.457221e-01 0.351 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 4.503775e-01 0.346 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 4.503775e-01 0.346 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 4.526209e-01 0.344 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 4.526209e-01 0.344 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.526209e-01 0.344 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 4.526209e-01 0.344 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.529958e-01 0.344 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.529958e-01 0.344 0 0
DNA replication initiation R-HSA-68952 4.529958e-01 0.344 0 0
Regulation of CDH11 function R-HSA-9762292 4.529958e-01 0.344 0 0
Binding and entry of HIV virion R-HSA-173107 4.529958e-01 0.344 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 4.529958e-01 0.344 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.529958e-01 0.344 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 4.576859e-01 0.339 0 0
Post-translational protein modification R-HSA-597592 4.667094e-01 0.331 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 4.678783e-01 0.330 0 0
HIV elongation arrest and recovery R-HSA-167287 4.678783e-01 0.330 0 0
Formation of the Early Elongation Complex R-HSA-113418 4.678783e-01 0.330 0 0
Pausing and recovery of HIV elongation R-HSA-167290 4.678783e-01 0.330 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 4.678783e-01 0.330 0 0
DAG1 core M3 glycosylations R-HSA-8932505 4.778115e-01 0.321 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.778115e-01 0.321 0 0
LGI-ADAM interactions R-HSA-5682910 4.778115e-01 0.321 0 0
vRNP Assembly R-HSA-192905 4.778115e-01 0.321 0 0
vRNA Synthesis R-HSA-192814 4.778115e-01 0.321 0 0
Bicarbonate transporters R-HSA-425381 4.778115e-01 0.321 0 0
Suppression of apoptosis R-HSA-9635465 4.778115e-01 0.321 0 0
Dissolution of Fibrin Clot R-HSA-75205 4.778115e-01 0.321 0 0
NGF-stimulated transcription R-HSA-9031628 4.812737e-01 0.318 0 0
Co-stimulation by CD28 R-HSA-389356 4.812737e-01 0.318 0 0
mRNA Capping R-HSA-72086 4.828793e-01 0.316 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 4.828793e-01 0.316 0 0
Glucagon-type ligand receptors R-HSA-420092 4.828793e-01 0.316 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 4.889908e-01 0.311 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 4.976158e-01 0.303 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.976158e-01 0.303 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.976158e-01 0.303 0 0
Ion channel transport R-HSA-983712 4.979902e-01 0.303 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 5.015028e-01 0.300 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 5.015028e-01 0.300 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 5.015028e-01 0.300 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 5.015028e-01 0.300 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 5.015028e-01 0.300 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 5.015028e-01 0.300 0 0
PI3K Cascade R-HSA-109704 5.043648e-01 0.297 0 0
Signaling by FGFR2 in disease R-HSA-5655253 5.043648e-01 0.297 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 5.085320e-01 0.294 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 5.085320e-01 0.294 0 0
Toll-like Receptor Cascades R-HSA-168898 5.099853e-01 0.292 0 0
Molecules associated with elastic fibres R-HSA-2129379 5.120810e-01 0.291 0 0
Inositol phosphate metabolism R-HSA-1483249 5.142321e-01 0.289 0 0
The phototransduction cascade R-HSA-2514856 5.157097e-01 0.288 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 5.181756e-01 0.286 0 0
Adipogenesis R-HSA-9843745 5.235847e-01 0.281 0 0
Scavenging by Class F Receptors R-HSA-3000484 5.241207e-01 0.281 0 0
Signaling by LTK R-HSA-9842663 5.241207e-01 0.281 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 5.241207e-01 0.281 0 0
Pervasive developmental disorders R-HSA-9005895 5.241207e-01 0.281 0 0
Disorders of Nervous System Development R-HSA-9697154 5.241207e-01 0.281 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.241207e-01 0.281 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 5.262691e-01 0.279 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 5.269139e-01 0.278 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 5.277297e-01 0.278 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 5.316972e-01 0.274 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 5.389073e-01 0.268 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 5.401755e-01 0.267 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 5.401755e-01 0.267 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 5.401755e-01 0.267 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.457136e-01 0.263 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 5.457136e-01 0.263 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 5.457136e-01 0.263 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 5.457136e-01 0.263 0 0
Maturation of nucleoprotein R-HSA-9683610 5.457136e-01 0.263 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 5.457136e-01 0.263 0 0
Interferon alpha/beta signaling R-HSA-909733 5.524111e-01 0.258 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.536661e-01 0.257 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 5.536661e-01 0.257 0 0
Miscellaneous transport and binding events R-HSA-5223345 5.537966e-01 0.257 0 0
G alpha (z) signalling events R-HSA-418597 5.596397e-01 0.252 0 0
ABC transporter disorders R-HSA-5619084 5.649837e-01 0.248 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.663280e-01 0.247 0 0
Signaling by FGFR4 in disease R-HSA-5655291 5.663280e-01 0.247 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 5.663280e-01 0.247 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 5.663280e-01 0.247 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 5.671295e-01 0.246 0 0
Signal amplification R-HSA-392518 5.671295e-01 0.246 0 0
eNOS activation R-HSA-203615 5.671295e-01 0.246 0 0
Hyaluronan metabolism R-HSA-2142845 5.671295e-01 0.246 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 5.671295e-01 0.246 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 5.740420e-01 0.241 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 5.746483e-01 0.241 0 0
Interferon gamma signaling R-HSA-877300 5.769691e-01 0.239 0 0
IRS-mediated signalling R-HSA-112399 5.806815e-01 0.236 0 0
Telomere C-strand synthesis initiation R-HSA-174430 5.860081e-01 0.232 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 5.860081e-01 0.232 0 0
p38MAPK events R-HSA-171007 5.860081e-01 0.232 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 5.860081e-01 0.232 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.860081e-01 0.232 0 0
Other semaphorin interactions R-HSA-416700 5.860081e-01 0.232 0 0
DCC mediated attractive signaling R-HSA-418885 5.860081e-01 0.232 0 0
Neuronal System R-HSA-112316 5.873684e-01 0.231 0 0
Glycosphingolipid transport R-HSA-9845576 5.929244e-01 0.227 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 5.929244e-01 0.227 0 0
FGFR2 mutant receptor activation R-HSA-1839126 5.929244e-01 0.227 0 0
Interleukin-1 signaling R-HSA-9020702 5.938265e-01 0.226 0 0
Extension of Telomeres R-HSA-180786 6.010765e-01 0.221 0 0
Triglyceride metabolism R-HSA-8979227 6.010765e-01 0.221 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 6.047963e-01 0.218 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 6.047963e-01 0.218 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 6.047963e-01 0.218 0 0
Activation of SMO R-HSA-5635838 6.047963e-01 0.218 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.047963e-01 0.218 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.047963e-01 0.218 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.047963e-01 0.218 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 6.091818e-01 0.215 0 0
RAB geranylgeranylation R-HSA-8873719 6.110259e-01 0.214 0 0
Elastic fibre formation R-HSA-1566948 6.175537e-01 0.209 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 6.227330e-01 0.206 0 0
Fibronectin matrix formation R-HSA-1566977 6.227330e-01 0.206 0 0
Galactose catabolism R-HSA-70370 6.227330e-01 0.206 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 6.227330e-01 0.206 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 6.227330e-01 0.206 0 0
Transmission across Chemical Synapses R-HSA-112315 6.261239e-01 0.203 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 6.294321e-01 0.201 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 6.294321e-01 0.201 0 0
Mitochondrial protein import R-HSA-1268020 6.304209e-01 0.200 0 0
Heme signaling R-HSA-9707616 6.304209e-01 0.200 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.343365e-01 0.198 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.398566e-01 0.194 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.398566e-01 0.194 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.398566e-01 0.194 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.398566e-01 0.194 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 6.398566e-01 0.194 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.398566e-01 0.194 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.398566e-01 0.194 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 6.398566e-01 0.194 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 6.410212e-01 0.193 0 0
HIV Transcription Elongation R-HSA-167169 6.410212e-01 0.193 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 6.410212e-01 0.193 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 6.410212e-01 0.193 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 6.410212e-01 0.193 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 6.410212e-01 0.193 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 6.410212e-01 0.193 0 0
Metabolism of amino acids and derivatives R-HSA-71291 6.469390e-01 0.189 0 0
Insulin receptor signalling cascade R-HSA-74751 6.491366e-01 0.188 0 0
Pyruvate metabolism R-HSA-70268 6.505137e-01 0.187 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 6.523228e-01 0.186 0 0
G alpha (s) signalling events R-HSA-418555 6.551733e-01 0.184 0 0
GAB1 signalosome R-HSA-180292 6.562040e-01 0.183 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.562040e-01 0.183 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.562040e-01 0.183 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.562040e-01 0.183 0 0
Platelet sensitization by LDL R-HSA-432142 6.562040e-01 0.183 0 0
Polo-like kinase mediated events R-HSA-156711 6.562040e-01 0.183 0 0
Apoptotic factor-mediated response R-HSA-111471 6.562040e-01 0.183 0 0
Mismatch Repair R-HSA-5358508 6.562040e-01 0.183 0 0
Potential therapeutics for SARS R-HSA-9679191 6.619455e-01 0.179 1 1
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.633391e-01 0.178 0 0
HIV Transcription Initiation R-HSA-167161 6.633391e-01 0.178 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.633391e-01 0.178 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.633391e-01 0.178 0 0
Intra-Golgi traffic R-HSA-6811438 6.633391e-01 0.178 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.718103e-01 0.173 0 0
The NLRP3 inflammasome R-HSA-844456 6.718103e-01 0.173 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.718103e-01 0.173 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 6.718103e-01 0.173 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 6.740727e-01 0.171 0 0
Activation of GABAB receptors R-HSA-991365 6.740727e-01 0.171 0 0
GABA B receptor activation R-HSA-977444 6.740727e-01 0.171 0 0
Cardiac conduction R-HSA-5576891 6.767228e-01 0.170 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 6.814132e-01 0.167 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 6.845266e-01 0.165 0 0
Signaling by SCF-KIT R-HSA-1433557 6.845266e-01 0.165 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 6.867090e-01 0.163 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.867090e-01 0.163 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 6.867090e-01 0.163 0 0
Signaling by NODAL R-HSA-1181150 6.867090e-01 0.163 0 0
Creatine metabolism R-HSA-71288 6.867090e-01 0.163 0 0
Pregnenolone biosynthesis R-HSA-196108 6.867090e-01 0.163 0 0
Disorders of transmembrane transporters R-HSA-5619115 6.938343e-01 0.159 0 0
Netrin-1 signaling R-HSA-373752 6.947040e-01 0.158 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 6.964859e-01 0.157 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.009323e-01 0.154 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 7.009323e-01 0.154 0 0
Signalling to RAS R-HSA-167044 7.009323e-01 0.154 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 7.032728e-01 0.153 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.046085e-01 0.152 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 7.075847e-01 0.150 0 0
ECM proteoglycans R-HSA-3000178 7.092519e-01 0.149 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 7.092519e-01 0.149 0 0
Mitochondrial protein degradation R-HSA-9837999 7.103491e-01 0.149 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.145107e-01 0.146 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 7.145107e-01 0.146 0 0
Serine metabolism R-HSA-977347 7.145107e-01 0.146 0 0
Signaling by PDGFR in disease R-HSA-9671555 7.145107e-01 0.146 0 0
Rab regulation of trafficking R-HSA-9007101 7.262166e-01 0.139 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 7.274734e-01 0.138 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.274734e-01 0.138 0 0
Fructose metabolism R-HSA-5652084 7.274734e-01 0.138 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 7.274734e-01 0.138 0 0
Potassium Channels R-HSA-1296071 7.307606e-01 0.136 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 7.398482e-01 0.131 0 0
Formation of the ureteric bud R-HSA-9830674 7.398482e-01 0.131 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 7.497085e-01 0.125 0 0
Extracellular matrix organization R-HSA-1474244 7.506560e-01 0.125 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 7.516619e-01 0.124 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 7.516619e-01 0.124 0 0
Complex III assembly R-HSA-9865881 7.516619e-01 0.124 0 0
SLC transporter disorders R-HSA-5619102 7.540016e-01 0.123 0 0
ABC-family proteins mediated transport R-HSA-382556 7.562730e-01 0.121 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 7.629398e-01 0.118 0 0
Laminin interactions R-HSA-3000157 7.629398e-01 0.118 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 7.629398e-01 0.118 0 0
TGFBR3 expression R-HSA-9839394 7.629398e-01 0.118 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 7.629398e-01 0.118 0 0
Formation of the cornified envelope R-HSA-6809371 7.663224e-01 0.116 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 7.737061e-01 0.111 0 0
Myogenesis R-HSA-525793 7.737061e-01 0.111 0 0
MET activates PTK2 signaling R-HSA-8874081 7.737061e-01 0.111 0 0
TRP channels R-HSA-3295583 7.737061e-01 0.111 0 0
Urea cycle R-HSA-70635 7.737061e-01 0.111 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 7.737061e-01 0.111 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.839841e-01 0.106 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.839841e-01 0.106 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 7.839841e-01 0.106 0 0
Signaling by FGFR3 in disease R-HSA-5655332 7.839841e-01 0.106 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 7.839841e-01 0.106 0 0
Insulin processing R-HSA-264876 7.839841e-01 0.106 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.933976e-01 0.101 0 0
Telomere Extension By Telomerase R-HSA-171319 7.937959e-01 0.100 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.937959e-01 0.100 0 0
Inflammasomes R-HSA-622312 7.937959e-01 0.100 0 0
Pyroptosis R-HSA-5620971 7.937959e-01 0.100 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 7.967537e-01 0.099 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 8.031627e-01 0.095 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.031627e-01 0.095 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.073375e-01 0.093 0 0
DAP12 signaling R-HSA-2424491 8.121044e-01 0.090 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.121044e-01 0.090 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 8.121044e-01 0.090 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.121044e-01 0.090 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 8.121044e-01 0.090 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.121044e-01 0.090 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.206405e-01 0.086 0 0
Downstream signal transduction R-HSA-186763 8.206405e-01 0.086 0 0
GABA receptor activation R-HSA-977443 8.233755e-01 0.084 0 0
tRNA Aminoacylation R-HSA-379724 8.233755e-01 0.084 0 0
Leishmania infection R-HSA-9658195 8.243571e-01 0.084 0 0
Parasitic Infection Pathways R-HSA-9824443 8.243571e-01 0.084 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.248613e-01 0.084 0 0
DAG1 glycosylations R-HSA-8931838 8.287893e-01 0.082 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 8.354765e-01 0.078 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 8.365683e-01 0.077 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 8.365683e-01 0.077 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 8.365683e-01 0.077 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 8.374145e-01 0.077 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 8.439944e-01 0.074 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.439944e-01 0.074 0 0
Ion transport by P-type ATPases R-HSA-936837 8.468234e-01 0.072 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 8.510834e-01 0.070 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.510834e-01 0.070 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 8.510834e-01 0.070 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.510834e-01 0.070 0 0
Signaling by Insulin receptor R-HSA-74752 8.517067e-01 0.070 0 0
Parasite infection R-HSA-9664407 8.525934e-01 0.069 0 0
Leishmania phagocytosis R-HSA-9664417 8.525934e-01 0.069 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.525934e-01 0.069 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 8.574544e-01 0.067 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.578508e-01 0.067 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.578508e-01 0.067 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 8.578508e-01 0.067 0 0
PERK regulates gene expression R-HSA-381042 8.578508e-01 0.067 0 0
Innate Immune System R-HSA-168249 8.590652e-01 0.066 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.606155e-01 0.065 0 0
GPVI-mediated activation cascade R-HSA-114604 8.643110e-01 0.063 0 0
RUNX2 regulates bone development R-HSA-8941326 8.643110e-01 0.063 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.643110e-01 0.063 0 0
RNA Polymerase III Transcription R-HSA-74158 8.643110e-01 0.063 0 0
Transcription of the HIV genome R-HSA-167172 8.674072e-01 0.062 0 0
FCERI mediated NF-kB activation R-HSA-2871837 8.703116e-01 0.060 0 0
Voltage gated Potassium channels R-HSA-1296072 8.704779e-01 0.060 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 8.763650e-01 0.057 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 8.800012e-01 0.056 0 0
Leishmania parasite growth and survival R-HSA-9664433 8.800012e-01 0.056 0 0
FOXO-mediated transcription R-HSA-9614085 8.845816e-01 0.053 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.873495e-01 0.052 0 0
Diseases of Immune System R-HSA-5260271 8.873495e-01 0.052 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 8.873495e-01 0.052 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 8.917135e-01 0.050 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 8.919748e-01 0.050 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 8.924706e-01 0.049 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.932737e-01 0.049 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.943711e-01 0.048 0 0
Interleukin-1 family signaling R-HSA-446652 8.949042e-01 0.048 0 0
Scavenging by Class A Receptors R-HSA-3000480 8.973592e-01 0.047 0 0
PPARA activates gene expression R-HSA-1989781 9.030303e-01 0.044 0 0
TBC/RABGAPs R-HSA-8854214 9.064806e-01 0.043 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.081392e-01 0.042 0 0
Cholesterol biosynthesis R-HSA-191273 9.082351e-01 0.042 0 0
DAP12 interactions R-HSA-2172127 9.107331e-01 0.041 0 0
Amine ligand-binding receptors R-HSA-375280 9.107331e-01 0.041 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.107331e-01 0.041 0 0
Platelet homeostasis R-HSA-418346 9.107966e-01 0.041 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.186674e-01 0.037 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.186674e-01 0.037 0 0
Signaling by TGFBR3 R-HSA-9839373 9.186674e-01 0.037 0 0
Diseases of DNA repair R-HSA-9675135 9.186674e-01 0.037 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.258974e-01 0.033 0 0
Metal ion SLC transporters R-HSA-425410 9.258974e-01 0.033 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.267770e-01 0.033 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.292680e-01 0.032 0 0
Complex IV assembly R-HSA-9864848 9.355567e-01 0.029 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.412870e-01 0.026 0 0
Nucleotide biosynthesis R-HSA-8956320 9.412870e-01 0.026 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.497356e-01 0.022 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.527800e-01 0.021 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.534839e-01 0.021 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.556010e-01 0.020 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.613921e-01 0.017 0 0
Signaling by PDGF R-HSA-186797 9.613921e-01 0.017 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.618714e-01 0.017 0 0
Complex I biogenesis R-HSA-6799198 9.631497e-01 0.016 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.641928e-01 0.016 0 0
PI Metabolism R-HSA-1483255 9.673925e-01 0.014 0 0
Kidney development R-HSA-9830369 9.694164e-01 0.013 0 0
Metabolism of steroid hormones R-HSA-196071 9.694164e-01 0.013 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.746186e-01 0.011 0 0
Metabolism of cofactors R-HSA-8978934 9.746186e-01 0.011 0 0
G alpha (q) signalling events R-HSA-416476 9.775034e-01 0.010 0 0
G alpha (i) signalling events R-HSA-418594 9.783404e-01 0.010 0 0
Keratinization R-HSA-6805567 9.793186e-01 0.009 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.793742e-01 0.009 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.812713e-01 0.008 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.816868e-01 0.008 0 0
Visual phototransduction R-HSA-2187338 9.824112e-01 0.008 0 0
Neurotransmitter release cycle R-HSA-112310 9.900150e-01 0.004 0 0
FCGR activation R-HSA-2029481 9.917158e-01 0.004 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.917158e-01 0.004 0 0
Metabolism of nucleotides R-HSA-15869 9.920683e-01 0.003 0 0
Bacterial Infection Pathways R-HSA-9824439 9.920749e-01 0.003 0 0
Collagen formation R-HSA-1474290 9.920937e-01 0.003 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.940257e-01 0.003 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.940655e-01 0.003 0 0
Drug ADME R-HSA-9748784 9.954435e-01 0.002 0 0
Peptide ligand-binding receptors R-HSA-375276 9.960277e-01 0.002 0 0
Metabolism of steroids R-HSA-8957322 9.961628e-01 0.002 0 0
Gastrulation R-HSA-9758941 9.963369e-01 0.002 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.964859e-01 0.002 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.965898e-01 0.001 0 0
GPCR downstream signalling R-HSA-388396 9.972847e-01 0.001 1 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.975416e-01 0.001 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.975416e-01 0.001 0 0
Peptide hormone metabolism R-HSA-2980736 9.977612e-01 0.001 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.983090e-01 0.001 0 0
Sensory perception of taste R-HSA-9717189 9.989411e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.989411e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.989470e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.989589e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.989895e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.991928e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.992370e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.992388e-01 0.000 1 0
Glycosaminoglycan metabolism R-HSA-1630316 9.994497e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.996395e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.997148e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.998880e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 9.999668e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999736e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999765e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999916e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999938e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.999986e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.999991e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999997e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways