NEK9

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A5A3E0 S1065 Sugiyama POTEF A26C1B ILASLSTFQQMWISKQEyDEsGPsIVHRKCL__________
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
A5A3E0 T949 Sugiyama POTEF A26C1B TVAsSSSLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
A5A3E0 Y940 Sugiyama POTEF A26C1B ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
B2RPK0 S121 Sugiyama HMGB1P1 HMG1L1 HMGB1L1 AFFLFCSEYHPKIKGEHPGLsIGDVAKKLGEMWNNTAADDK
B2RPK0 S15 Sugiyama HMGB1P1 HMG1L1 HMGB1L1 ______MGKGDPKKPRGKMssyAFFVQtCREEHKKKHSDAS
B2RPK0 T22 Sugiyama HMGB1P1 HMG1L1 HMGB1L1 GKGDPKKPRGKMssyAFFVQtCREEHKKKHSDASVNFSEFS
O00115 S57 Sugiyama DNASE2 DNASE2A DNL2 ALRGSGEAAQRGLQYKyLDEssGGWRDGRALINsPEGAVGR
O00151 S31 Sugiyama PDLIM1 CLIM1 CLP36 PGPWGFRLVGGKDFEQPLAIsRVtPGSKAALANLCIGDVIT
O00170 S53 Sugiyama AIP XAP2 KATFHYRtLHsDDEGtVLDDsRARGKPMELIIGKKFKLPVW
O00170 T48 Sugiyama AIP XAP2 FQDGTKATFHYRtLHsDDEGtVLDDsRARGKPMELIIGKKF
O00273 S302 Sugiyama DFFA DFF1 DFF45 H13 TETVQEACERELALRLQQtQsLHsLRsIsAsKAsPPGDLQN
O00273 T300 Sugiyama DFFA DFF1 DFF45 H13 KKTETVQEACERELALRLQQtQsLHsLRsIsAsKAsPPGDL
O14737 S42 Sugiyama PDCD5 TFAR19 GDPGDAAQQEAKHREAEMRNsILAQVLDQsARARLsNLALV
O14737 S51 Sugiyama PDCD5 TFAR19 EAKHREAEMRNsILAQVLDQsARARLsNLALVKPEKTKAVE
O15212 S53 Sugiyama PFDN6 HKE2 PFD6 LEAQLtENNIVKEELALLDGsNVVFKLLGPVLVKQELGEAR
O15355 S349 Sugiyama PPM1G PPM1C tTAVVALIRGKQLIVANAGDsRCVVsEAGKALDMsyDHKPE
O15446 S64 Sugiyama POLR1G ASE1 CAST CD3EAP PAF49 LIQAPADFAPECFNGRHVPLsGsQIVKGKLAGKRHRyRVLS
O43290 T430 Sugiyama SART1 RKKEKEVVVRADDLLPLGDQtQDGDFGsRLRGRGRRRVsEV
O43390 T141 Sugiyama HNRNPR HNRPR GPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVYSGVQP
O43390 Y136 Sugiyama HNRNPR HNRPR QESTKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVY
O43399 S21 Sugiyama TPD52L2 MDsAGQDINLNsPNKGLLsDsMtDVPVDTGVAARtPAVEGL
O43423 S100 Sugiyama ANP32CP PP32R1 AEKCPNLTHLYLSGNKIKDLstIEPLKQLENLKSLDLFNCE
O43615 S94 Sugiyama TIMM44 MIMT44 TIM44 NKEMKESIKKFRDEARRLEEsDVLQEARRKyKtIESETVRT
O43715 S32 Sugiyama TRIAP1 15E1.1 HSPC132 KREYDQCFNRWFAEKFLKGDssGDPCTDLFKRYQQCVQKAI
O43852 S261 Sugiyama CALU RDKNRDGKMDKEEtKDWILPsDyDHAEAEARHLVyEsDQNK
O43852 S44 Sugiyama CALU KKDRVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQL
O43852 S69 Sugiyama CALU HDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKDGFVt
O60506 T138 Sugiyama SYNCRIP HNRPQ NSAP1 GPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVYSGQQP
O60506 Y133 Sugiyama SYNCRIP HNRPQ NSAP1 ADSSKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVY
O60814 S39 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
O60841 S222 Sugiyama EIF5B IF2 KIAA0741 KNQKNKPGPNIEsGNEDDDAsFKIKTVAQKKAEKKERERKK
O60927 T75 Sugiyama PPP1R11 HCGV TCTE5 RRssKCCCIyEKPRAFGEsstEsDEEEEEGCGHtHCVRGHR
O75348 S65 Sugiyama ATP6V1G1 ATP6G ATP6G1 ATP6J EQyRLQREKEFKAKEAAALGsRGsCstEVEKETQEKMTILQ
O75534 S782 Sugiyama CSDE1 D1S155E KIAA0885 NRU UNR LDDAsAPRLMVLRQPRGPDNsMGFGAERKIRQAGVID____
O75821 S189 Sugiyama EIF3G EIF3S4 CPYKDtLGPMQKELAEQLGLstGEKEKLPGELEPVQAtQNK
O95218 S181 Sugiyama ZRANB2 ZIS ZNF265 DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
O95626 S104 Sugiyama ANP32D PP32R2 AEKCPNLIHLNLSGNKIKDLstIEPLKKLENLESLDLFTCE
O95678 S162 Sugiyama KRT75 K6HF KB18 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
O95757 S599 Sugiyama HSPA4L APG1 HSPH3 OSP94 sIDLPIQssLCRQLGQDLLNsyIENEGKMIMQDKLEKERND
O95757 Y600 Sugiyama HSPA4L APG1 HSPH3 OSP94 IDLPIQssLCRQLGQDLLNsyIENEGKMIMQDKLEKERNDA
P00338 S105 Sugiyama LDHA PIG19 VTANsKLVIItAGARQQEGEsRLNLVQRNVNIFKFIIPNVV
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00338 S167 Sugiyama LDHA PIG19 AWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVHPLSCHG
P00338 T322 Sugiyama LDHA PIG19 DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P02538 S176 Sugiyama KRT6A K6A KRT6D IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P04075 S336 Sugiyama ALDOA ALDA GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04083 S201 Sugiyama ANXA1 ANX1 LPC1 LsLAKGDRsEDFGVNEDLADsDARALyEAGERRKGtDVNVF
P04259 S176 Sugiyama KRT6B K6B KRTL1 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406 S151 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 FVMGVNHEKYDNSLKIIsNAsCttNCLAPLAKVIHDNFGIV
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 S312 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 sstFDAGAGIALNDHFVKLIsWyDNEFGysNRVVDLMAHMA
P04406 S321 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IALNDHFVKLIsWyDNEFGysNRVVDLMAHMAsKE______
P04406 T154 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 GVNHEKYDNSLKIIsNAsCttNCLAPLAKVIHDNFGIVEGL
P04406 T246 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 GKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKVVKQAS
P04792 S187 Sugiyama HSPB1 HSP27 HSP28 APMPKLAtQsNEItIPVtFEsRAQLGGPEAAKsDETAAK__
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04792 S86 Sugiyama HSPB1 HSP27 HSP28 PAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNHFAP
P04792 T180 Sugiyama HSPB1 HSP27 HSP28 EGtLTVEAPMPKLAtQsNEItIPVtFEsRAQLGGPEAAKsD
P05198 S219 Sugiyama EIF2S1 EIF2A CYGYEGIDAVKEALRAGLNCsTENMPIKINLIAPPRYVMTT
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05455 S325 Sugiyama SSB VLEGEVEKEALKKIIEDQQEsLNKWKSKGRRFKGKGKGNKA
P05787 S104 Sugiyama KRT8 CYK8 IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P06703 S46 Sugiyama S100A6 CACY KHTLSKKELKELIQKELtIGsKLQDAEIARLMEDLDRNKDQ
P06703 T43 Sugiyama S100A6 CACY EGDKHTLSKKELKELIQKELtIGsKLQDAEIARLMEDLDRN
P06733 S14 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 _______MSILKIHAREIFDsRGNPtVEVDLFtsKGLFRAA
P06733 S27 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P06733 S37 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 NPtVEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRY
P06733 T100 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 KKLNVtEQEKIDKLMIEMDGtENKsKFGANAILGVsLAVCK
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06733 T41 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 EVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKG
P06748 S137 Sugiyama NPM1 NPM VAVEEDAEsEDEEEEDVKLLsIsGKRsAPGGGsKVPQKKVK
P07195 S106 Sugiyama LDHB VtANSKIVVVtAGVRQQEGEsRLNLVQRNVNVFKFIIPQIV
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 S168 Sugiyama LDHB TWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIHPSSCHG
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195 S44 Sugiyama LDHB ITVVGVGQVGMACAISILGKsLADELALVDVLEDKLKGEMM
P07195 T302 Sugiyama LDHB YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07305 S66 Sugiyama H1-0 H1F0 H1FV SRQsIQKYIKSHYKVGENADsQIKLsIKRLVTTGVLKQTKG
P07305 S71 Sugiyama H1-0 H1F0 H1FV QKYIKSHYKVGENADsQIKLsIKRLVTTGVLKQTKGVGASG
P07437 S115 Sugiyama TUBB TUBB5 OK/SW-cl.56 sGAGNNWAKGHytEGAELVDsVLDVVRKEAESCDCLQGFQL
P07437 S75 Sugiyama TUBB TUBB5 OK/SW-cl.56 tGGKyVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
P07737 S57 Sugiyama PFN1 GKtFVNITPAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDs
P07737 S85 Sugiyama PFN1 tLGGQKCsVIRDsLLQDGEFsMDLRtKstGGAPTFNVtVtK
P07737 T65 Sugiyama PFN1 PAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQDGEFs
P07814 S335 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 PIEKNLQMWEEMKKGsQFGQsCCLRAKIDMSSNNGCMRDPt
P07814 T1506 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 LCELQPGAKCVCGKNPAKyytLFGRsy______________
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07864 S167 Sugiyama LDHC LDH3 LDHX VWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVHPTSCHG
P07900 S399 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNLVKK
P07900 S53 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P08195 S292 Sugiyama SLC3A2 MDU1 VAQtDLLQIDPNFGsKEDFDsLLQsAKKKSIRVILDLTPNY
P08195 S296 Sugiyama SLC3A2 MDU1 DLLQIDPNFGsKEDFDsLLQsAKKKSIRVILDLTPNYRGEN
P08195 S403 Sugiyama SLC3A2 MDU1 SDLQQILSLLESNKDLLLtssyLsDsGstGEHtKSLVTQYL
P08195 S598 Sugiyama SLC3A2 MDU1 LQASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEP
P08195 T599 Sugiyama SLC3A2 MDU1 QASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEPH
P08238 S391 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNIVKK
P08238 S45 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238 S468 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238 S470 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB RLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItGEs
P08238 S48 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08238 S497 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB KEtQKsIyyItGEsKEQVANsAFVERVRKRGFEVVyMtEPI
P08238 S532 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB yMtEPIDEyCVQQLKEFDGKsLVsVtKEGLELPEDEEEKKK
P08238 S535 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB EPIDEyCVQQLKEFDGKsLVsVtKEGLELPEDEEEKKKMEE
P08238 Y457 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB LKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMK
P08729 S104 Sugiyama KRT7 SCL LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P09104 S37 Sugiyama ENO2 NPtVEVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRY
P09104 T41 Sugiyama ENO2 EVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRYLGKG
P09382 S63 Sugiyama LGALS1 CLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVFPFQPG
P09382 T58 Sugiyama LGALS1 DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P09429 S121 Sugiyama HMGB1 HMG1 AFFLFCSEYRPKIKGEHPGLsIGDVAKKLGEMWNNTAADDK
P09429 S15 Sugiyama HMGB1 HMG1 ______MGKGDPKKPRGKMssyAFFVQtCREEHKKKHPDAs
P09429 S35 Sugiyama HMGB1 HMG1 syAFFVQtCREEHKKKHPDAsVNFsEFsKKCsERWKtMsAK
P09429 S42 Sugiyama HMGB1 HMG1 tCREEHKKKHPDAsVNFsEFsKKCsERWKtMsAKEKGKFED
P09429 T22 Sugiyama HMGB1 HMG1 GKGDPKKPRGKMssyAFFVQtCREEHKKKHPDAsVNFsEFs
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P09661 S212 Sugiyama SNRPA1 KKGGPsPGDVEAIKNAIANAstLAEVERLKGLLQsGQIPGR
P09661 S226 Sugiyama SNRPA1 NAIANAstLAEVERLKGLLQsGQIPGRERRsGPtDDGEEEM
P09874 S185 Sugiyama PARP1 ADPRT PPOL KNREELGFRPEYsAsQLKGFsLLAtEDKEALKKQLPGVKSE
P09874 T189 Sugiyama PARP1 ADPRT PPOL ELGFRPEYsAsQLKGFsLLAtEDKEALKKQLPGVKSEGKRK
P0CG38 S1065 Sugiyama POTEI ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1028 Sugiyama POTEJ ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0DPH7 T73 Sugiyama TUBA3C TUBA2 FsEtGAGKHVPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLI
P0DPH7 T80 Sugiyama TUBA3C TUBA2 KHVPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLItGKEDAA
P0DPH7 T82 Sugiyama TUBA3C TUBA2 VPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLItGKEDAANN
P0DPH7 Y83 Sugiyama TUBA3C TUBA2 PRAVFVDLEPtVVDEVRtGtyRQLFHPEQLItGKEDAANNy
P10412 S41 Sugiyama H1-4 H1F4 HIST1H1E KKKARKsAGAAKRKAsGPPVsELItKAVAASKERsGVsLAA
P10412 S55 Sugiyama H1-4 H1F4 HIST1H1E AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P10412 S58 Sugiyama H1-4 H1F4 HIST1H1E PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P10412 T45 Sugiyama H1-4 H1F4 HIST1H1E RKsAGAAKRKAsGPPVsELItKAVAASKERsGVsLAALKKA
P10809 S453 Sugiyama HSPD1 HSP60 EEGIVLGGGCALLRCIPALDsLtPANEDQKIGIEIIKRTLK
P10809 T428 Sugiyama HSPD1 HSP60 GtsDVEVNEKKDRVtDALNAtRAAVEEGIVLGGGCALLRCI
P11142 S85 Sugiyama HSPA8 HSC70 HSP73 HSPA10 NtVFDAKRLIGRRFDDAVVQsDMKHWPFMVVNDAGRPKVQV
P11142 T163 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142 T47 Sugiyama HSPA8 HSC70 HSP73 HSPA10 EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtNtV
P11142 Y41 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P11940 T191 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 GRFKSRKEREAELGARAKEFtNVyIKNFGEDMDDERLKDLF
P11940 T319 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 KNLDDGIDDERLRKEFsPFGtItsAKVMMEGGRSKGFGFVC
P11940 Y194 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 KSRKEREAELGARAKEFtNVyIKNFGEDMDDERLKDLFGKF
P12035 S211 Sugiyama KRT3 IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P13639 S38 Sugiyama EEF2 EF2 NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13639 S732 Sugiyama EEF2 EF2 DAIHRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQCP
P13639 T735 Sugiyama EEF2 EF2 HRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQCPEQV
P13647 S181 Sugiyama KRT5 IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13667 S468 Sugiyama PDIA4 ERP70 ERP72 ytFAIADEEDyAGEVKDLGLsEsGEDVNAAILDEsGKKFAM
P13667 S482 Sugiyama PDIA4 ERP70 ERP72 VKDLGLsEsGEDVNAAILDEsGKKFAMEPEEFDsDtLREFV
P13929 S37 Sugiyama ENO3 NPtVEVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRY
P13929 T41 Sugiyama ENO3 EVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRYLGKG
P13987 T76 Sugiyama CD59 MIC11 MIN1 MIN2 MIN3 MSK21 AGLQVYNKCWKFEHCNFNDVtTRLRENELtyyCCKKDLCNF
P14314 S478 Sugiyama PRKCSH G19P1 DKFSAMKyEQGtGCWQGPNRstTVRLLCGKEtMVtStTEPS
P14618 S202 Sugiyama PKM OIP3 PK2 PK3 PKM2 SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs
P14618 S205 Sugiyama PKM OIP3 PK2 PK3 PKM2 VKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVsEKD
P14618 S77 Sugiyama PKM OIP3 PK2 PK3 PKM2 sVEtLKEMIKsGMNVARLNFsHGtHEyHAEtIKNVRtAtEs
P14618 T195 Sugiyama PKM OIP3 PK2 PK3 PKM2 yVDDGLISLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAA
P14618 T87 Sugiyama PKM OIP3 PK2 PK3 PKM2 sGMNVARLNFsHGtHEyHAEtIKNVRtAtEsFAsDPILyRP
P14625 S106 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625 S109 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P14625 S64 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 tDDEVVQREEEAIQLDGLNAsQIRELREKSEKFAFQAEVNR
P14625 S674 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 WsGNMERIMKAQAYQtGKDIstNyyAsQKKTFEINPRHPLI
P15311 S413 Sugiyama EZR VIL2 RMAALRAKEELERQAVDQIKsQEQLAAELAEytAKIALLEE
P15311 S535 Sugiyama EZR VIL2 EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15311 T425 Sugiyama EZR VIL2 RQAVDQIKsQEQLAAELAEytAKIALLEEARRRKEDEVEEW
P15311 T533 Sugiyama EZR VIL2 NEEKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDII
P16070 T76 Sugiyama CD44 LHR MDU2 MDU3 MIC4 FNSTLPTMAQMEKALsIGFEtCRyGFIEGHVVIPRIHPNSI
P16402 S42 Sugiyama H1-3 H1F3 HIST1H1D KKAKKAGATAGKRKAsGPPVsELItKAVAASKERsGVsLAA
P16402 S56 Sugiyama H1-3 H1F3 HIST1H1D AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16402 S59 Sugiyama H1-3 H1F3 HIST1H1D PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P16402 T46 Sugiyama H1-3 H1F3 HIST1H1D KAGATAGKRKAsGPPVsELItKAVAASKERsGVsLAALKKA
P16403 S41 Sugiyama H1-2 H1F2 HIST1H1C KKKAAKKAGGtPRKAsGPPVsELItKAVAASKERsGVsLAA
P16403 S55 Sugiyama H1-2 H1F2 HIST1H1C AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403 S58 Sugiyama H1-2 H1F2 HIST1H1C PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P16403 T45 Sugiyama H1-2 H1F2 HIST1H1C AKKAGGtPRKAsGPPVsELItKAVAASKERsGVsLAALKKA
P17275 S312 Sugiyama JUNB RIARLEDKVKTLKAENAGLSstAGLLREQVAQLKQKVMTHV
P17275 T313 Sugiyama JUNB IARLEDKVKTLKAENAGLSstAGLLREQVAQLKQKVMTHVS
P17987 S119 Sugiyama TCP1 CCT1 CCTA ELLKNADELVKQKIHPTSVIsGYRLACKEAVRYINENLIVN
P18615 S135 Sugiyama NELFE RD RDBP sADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEG
P18615 S138 Sugiyama NELFE RD RDBP DDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEGPGA
P18621 S141 Sugiyama RPL17 KAPKMRRRTYRAHGRINPyMssPCHIEMILtEKEQIVPKPE
P18621 T151 Sugiyama RPL17 RAHGRINPyMssPCHIEMILtEKEQIVPKPEEEVAQKKKIS
P19338 S458 Sugiyama NCL TEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKN
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19338 S619 Sugiyama NCL RIVTDRETGssKGFGFVDFNsEEDAKAAKEAMEDGEIDGNK
P20042 S67 Sugiyama EIF2S2 EIF2B EPtEDKDLEADEEDTRKKDAsDDLDDLNFFNQKKKKKKTKK
P20290 S30 Sugiyama BTF3 NACB OK/SW-cl.8 ADSRGRGRARGGCPGGEAtLsQPPPRGGTRGQEPQMKETIM
P20290 T28 Sugiyama BTF3 NACB OK/SW-cl.8 AQADSRGRGRARGGCPGGEAtLsQPPPRGGTRGQEPQMKET
P20618 S157 Sugiyama PSMB1 PSC5 IIGGLDEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLL
P20618 S162 Sugiyama PSMB1 PSC5 DEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLLDNQVG
P20674 T105 Sugiyama COX5A EPKIIDAALRACRRLNDFAstVRILEVVKDKAGPHKEIYPY
P20810 S297 Sugiyama CAST KKRKVEKDtMsDQALEALsAsLGTRQAEPELDLRsIKEVDE
P22626 S212 Sugiyama HNRNPA2B1 HNRPA2B1 EMQEVQssRsGRGGNFGFGDsRGGGGNFGPGPGsNFRGGsD
P23246 S283 Sugiyama SFPQ PSF GPGGRsEEKIsDsEGFKANLsLLRRPGEKTyTQRCRLFVGN
P23396 S35 Sugiyama RPS3 OK/SW-cl.26 GIFKAELNEFLtRELAEDGysGVEVRVtPTRTEIIILATRT
P23396 T26 Sugiyama RPS3 OK/SW-cl.26 sKKRKFVADGIFKAELNEFLtRELAEDGysGVEVRVtPTRT
P23526 S183 Sugiyama AHCY SAHH NLyKMMANGILKVPAINVNDsVtKsKFDNLyGCRESLIDGI
P23528 T63 Sugiyama CFL1 CFL DKKNIILEEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyA
P25398 S107 Sugiyama RPS12 EWVGLCKIDREGKPRKVVGCsCVVVKDYGKESQAKDVIEEy
P25786 T11 Sugiyama PSMA1 HC2 NU PROS30 PSC2 __________MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQ
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373 T148 Sugiyama RPL13 BBC1 OK/SW-cl.46 PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373 T151 Sugiyama RPL13 BBC1 OK/SW-cl.46 PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P26583 S15 Sugiyama HMGB2 HMG2 ______MGKGDPNKPRGKMssyAFFVQtCREEHKKKHPDss
P26583 S35 Sugiyama HMGB2 HMG2 syAFFVQtCREEHKKKHPDssVNFAEFSKKCSERWKTMSAK
P26583 T22 Sugiyama HMGB2 HMG2 GKGDPNKPRGKMssyAFFVQtCREEHKKKHPDssVNFAEFS
P26639 S522 Sugiyama TARS1 TARS PEKFLGDIEVWDQAEKQLENsLNEFGEKWELNsGDGAFyGP
P27348 S145 Sugiyama YWHAQ YFRyLAEVACGDDRKQtIDNsQGAyQEAFDIsKKEMQPTHP
P27348 S156 Sugiyama YWHAQ DDRKQtIDNsQGAyQEAFDIsKKEMQPTHPIRLGLALNFSV
P27695 S129 Sugiyama APEX1 APE APE1 APEX APX HAP1 REF1 QELPGLSHQYWSAPsDKEGysGVGLLsRQCPLKVsyGIGDE
P27695 S135 Sugiyama APEX1 APE APE1 APEX APX HAP1 REF1 SHQYWSAPsDKEGysGVGLLsRQCPLKVsyGIGDEEHDQEG
P27695 T97 Sugiyama APEX1 APE APE1 APEX APX HAP1 REF1 KKKGLDWVKEEAPDILCLQEtKCSENKLPAELQELPGLSHQ
P27695 Y128 Sugiyama APEX1 APE APE1 APEX APX HAP1 REF1 LQELPGLSHQYWSAPsDKEGysGVGLLsRQCPLKVsyGIGD
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27797 S53 Sugiyama CALR CRTC WtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDAR
P29401 S190 Sugiyama TKT ASIYKLDNLVAILDINRLGQsDPAPLQHQMDIyQKRCEAFG
P29692 S37 Sugiyama EEF1D EF1D KYDDAERRFyEQMNGPVAGAsRQENGAsVILRDIARARENI
P29692 S44 Sugiyama EEF1D EF1D RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P29692 S64 Sugiyama EEF1D EF1D sVILRDIARARENIQKsLAGssGPGAssGtsGDHGELVVRI
P29692 S65 Sugiyama EEF1D EF1D VILRDIARARENIQKsLAGssGPGAssGtsGDHGELVVRIA
P30041 S186 Sugiyama PRDX6 AOP2 KIAA0106 SLQLTAEKRVAtPVDWKDGDsVMVLPtIPEEEAKKLFPKGV
P30041 T192 Sugiyama PRDX6 AOP2 KIAA0106 EKRVAtPVDWKDGDsVMVLPtIPEEEAKKLFPKGVFtKELP
P30050 S138 Sugiyama RPL12 HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30050 S26 Sugiyama RPL12 DPNEIKVVYLRCtGGEVGAtsALAPKIGPLGLsPKKVGDDI
P30086 S139 Sugiyama PEBP1 PBP PEBP RyVWLVyEQDRPLKCDEPILsNRsGDHRGKFKVAsFRKKyE
P30086 S52 Sugiyama PEBP1 PBP PEBP AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P30086 S60 Sugiyama PEBP1 PBP PEBP VLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPDAPsRKDPK
P30533 S230 Sugiyama LRPAP1 A2MRAP SDIKGSVLHSRHTELKEKLRsINQGLDRLRRVsHQGystEA
P31943 S285 Sugiyama HNRNPH1 HNRPH HNRPH1 NyCFsGMsDHRyGDGGstFQsttGHCVHMRGLPYRAtENDI
P31948 S16 Sugiyama STIP1 _____MEQVNELKEKGNKALsVGNIDDALQCysEAIKLDPH
P31948 S28 Sugiyama STIP1 KEKGNKALsVGNIDDALQCysEAIKLDPHNHVLysNRsAAy
P31948 S459 Sugiyama STIP1 EAMKDytKAMDVYQKALDLDssCKEAADGYQRCMMAQyNRH
P31948 S460 Sugiyama STIP1 AMKDytKAMDVYQKALDLDssCKEAADGYQRCMMAQyNRHD
P33176 S443 Sugiyama KIF5B KNS KNS1 EEIAKLYKQLDDKDEEINQQsQLVEKLKTQMLDQEELLAST
P33176 S950 Sugiyama KIF5B KNS KNS1 PAAsPtHPSAIRGGGAFVQNsQPVAVRGGGGKQV_______
P33316 S164 Sugiyama DUT YTIPPMEKAVVKTDIQIALPsGCyGRVAPRSGLAAKHFIDV
P34931 T49 Sugiyama HSPA1L EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQNTV
P34931 Y43 Sugiyama HSPA1L FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P35269 S431 Sugiyama GTF2F1 RAP74 GKRVSEMPAAKRLRLDtGPQsLsGKstPQPPsGKttPNsGD
P35269 S436 Sugiyama GTF2F1 RAP74 EMPAAKRLRLDtGPQsLsGKstPQPPsGKttPNsGDVQVTE
P35269 T437 Sugiyama GTF2F1 RAP74 MPAAKRLRLDtGPQsLsGKstPQPPsGKttPNsGDVQVTED
P35579 S1304 Sugiyama MYH9 NVtGLLsQsDSKSSKLTKDFsALEsQLQDtQELLQEENRQK
P35579 S1308 Sugiyama MYH9 LLsQsDSKSSKLTKDFsALEsQLQDtQELLQEENRQKLsLs
P35579 S1714 Sugiyama MYH9 RAKRQAQQERDELADEIANssGKGALALEEKRRLEARIAQL
P35579 S1892 Sugiyama MYH9 LKQLKRQLEEAEEEAQRANAsRRKLQRELEDAtEtADAMNR
P35579 S1915 Sugiyama MYH9 KLQRELEDAtEtADAMNREVssLKNKLRRGDLPFVVPRRMA
P35579 S1916 Sugiyama MYH9 LQRELEDAtEtADAMNREVssLKNKLRRGDLPFVVPRRMAR
P35579 S876 Sugiyama MYH9 KVREKQLAAENRLTEMEtLQsQLMAEKLQLQEQLQAETELC
P35579 T1313 Sugiyama MYH9 DSKSSKLTKDFsALEsQLQDtQELLQEENRQKLsLstKLKQ
P35579 T1904 Sugiyama MYH9 EEAQRANAsRRKLQRELEDAtEtADAMNREVssLKNKLRRG
P35579 T1906 Sugiyama MYH9 AQRANAsRRKLQRELEDAtEtADAMNREVssLKNKLRRGDL
P35579 T873 Sugiyama MYH9 ELVKVREKQLAAENRLTEMEtLQsQLMAEKLQLQEQLQAET
P35580 S1371 Sugiyama MYH10 QQEEEEEARKNLEKQVLALQsQLADtKKKVDDDLGTIESLE
P35580 T1376 Sugiyama MYH10 EEARKNLEKQVLALQsQLADtKKKVDDDLGTIESLEEAKKK
P35637 S360 Sugiyama FUS TLS sFDDPPsAKAAIDWFDGKEFsGNPIKVsFATRRADFNRGGG
P35908 S191 Sugiyama KRT2 KRT2A KRT2E IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P36578 S365 Sugiyama RPL4 RPL1 RNHKLRVDKAAAAAAALQAKsDEKAAVAGKKPVVGKKGKKA
P36578 S55 Sugiyama RPL4 RPL1 DIVNFVHTNLRKNNRQPyAVsELAGHQtsAEsWGtGRAVAR
P36578 S66 Sugiyama RPL4 RPL1 KNNRQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGGGtHR
P36578 S87 Sugiyama RPL4 RPL1 WGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAPTKT
P36578 T62 Sugiyama RPL4 RPL1 TNLRKNNRQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGG
P36578 T69 Sugiyama RPL4 RPL1 RQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGGGtHRsGQ
P36578 T84 Sugiyama RPL4 RPL1 AEsWGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAP
P37802 S145 Sugiyama TAGLN2 KIAA0120 CDABP0035 VQRTLMNLGGLAVARDDGLFsGDPNWFPKKSKENPRNFsDN
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P37802 T190 Sugiyama TAGLN2 KIAA0120 CDABP0035 GKNVIGLQMGtNRGAsQAGMtGyGMPRQIL___________
P37802 Y192 Sugiyama TAGLN2 KIAA0120 CDABP0035 NVIGLQMGtNRGAsQAGMtGyGMPRQIL_____________
P38646 T116 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646 T120 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P38646 Y118 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 ERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIK
P39019 S59 Sugiyama RPS19 LAKHKELAPyDENWFytRAAstARHLYLRGGAGVGsMTKIY
P39019 S93 Sugiyama RPS19 GsMTKIYGGRQRNGVMPsHFsRGsKsVARRVLQALEGLKMV
P39019 T36 Sugiyama RPS19 RALAAFLKKSGKLKVPEWVDtVKLAKHKELAPyDENWFytR
P39019 T55 Sugiyama RPS19 DtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGsM
P39019 T60 Sugiyama RPS19 AKHKELAPyDENWFytRAAstARHLYLRGGAGVGsMTKIYG
P39019 Y54 Sugiyama RPS19 VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P39687 S104 Sugiyama ANP32A C15orf1 LANP MAPM PHAP1 AEKCPNLTHLNLsGNKIKDLstIEPLKKLENLKsLDLFNCE
P39687 S27 Sugiyama ANP32A C15orf1 LANP MAPM PHAP1 IHLELRNRtPsDVKELVLDNsRsNEGKLEGLTDEFEELEFL
P42677 S78 Sugiyama RPS27 MPS1 GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P42766 S29 Sugiyama RPL35 LRGKKKEELLKQLDDLKVELsQLRVAKVTGGAASKLsKIRV
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46776 S83 Sugiyama RPL27A LKRNQsFCPtVNLDKLWtLVsEQtRVNAAKNKtGAAPIIDV
P46776 T72 Sugiyama RPL27A yFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRVNAAK
P46776 T80 Sugiyama RPL27A HYHLKRNQsFCPtVNLDKLWtLVsEQtRVNAAKNKtGAAPI
P46777 S172 Sugiyama RPL5 MSTP030 RTTTGNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNA
P46777 S176 Sugiyama RPL5 MSTP030 GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P46777 T177 Sugiyama RPL5 MSTP030 NKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHRK
P46778 T29 Sugiyama RPL21 RGTRYMFSRPFRKHGVVPLAtyMRIYKKGDIVDIKGMGTVQ
P46778 Y30 Sugiyama RPL21 GTRYMFSRPFRKHGVVPLAtyMRIYKKGDIVDIKGMGTVQK
P46783 S146 Sugiyama RPS10 TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P46783 T148 Sugiyama RPS10 RRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ___
P46937 S388 Sugiyama YAP1 YAP65 PGMsQELRTMttNssDPFLNsGtyHsRDEstDsGLsMssys
P46937 S405 Sugiyama YAP1 YAP65 FLNsGtyHsRDEstDsGLsMssysVPRtPDDFLNsVDEMDT
P47756 S192 Sugiyama CAPZB TVMLWLQTNKSGsGtMNLGGsLtRQMEKDEtVsDCsPHIAN
P47914 S142 Sugiyama RPL29 KAKAKAKAKDQTKAQAAAPAsVPAQAPKRtQAPtKAsE___
P47914 T151 Sugiyama RPL29 DQTKAQAAAPAsVPAQAPKRtQAPtKAsE____________
P48668 S176 Sugiyama KRT6C KRT6E IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P50991 S51 Sugiyama CCT4 CCTD SRB AQIRFsNISAAKAVADAIRtsLGPKGMDKMIQDGKGDVtIt
P50991 T50 Sugiyama CCT4 CCTD SRB PAQIRFsNISAAKAVADAIRtsLGPKGMDKMIQDGKGDVtI
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51116 T598 Sugiyama FXR2 FMR1L2 DESRPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRA
P51116 T610 Sugiyama FXR2 FMR1L2 RRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQsRQRPPLER
P52272 S633 Sugiyama HNRNPM HNRPM NAGR1 GGGGAsFDRAIEMERGNFGGsFAGsFGGAGGHAPGVARKAC
P52272 S637 Sugiyama HNRNPM HNRPM NAGR1 AsFDRAIEMERGNFGGsFAGsFGGAGGHAPGVARKACQIFV
P54652 T48 Sugiyama HSPA2 EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTNTI
P54652 Y42 Sugiyama HSPA2 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P55854 S27 Sugiyama SUMO3 SMT3A SMT3H1 KEGVKTENDHINLKVAGQDGsVVQFKIKRHTPLSKLMKAYC
P57053 S39 Sugiyama H2BC12L H2BFS H2BS1 VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P58876 S39 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60174 S97 Sugiyama TPI1 TPI GEIsPGMIKDCGAtWVVLGHsERRHVFGEsDELIGQKVAHA
P60174 T217 Sugiyama TPI1 TPI VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60174 T90 Sugiyama TPI1 TPI VTNGAFtGEIsPGMIKDCGAtWVVLGHsERRHVFGEsDELI
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S365 Sugiyama ACTB ILAsLstFQQMWISKQEyDEsGPsIVHRKCF__________
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 S60 Sugiyama ACTB HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P60709 T249 Sugiyama ACTB tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P60709 Y240 Sugiyama ACTB ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P60842 S78 Sugiyama EIF4A1 DDX2A EIF4A IQQRAILPCIKGyDVIAQAQsGtGKTATFAISILQQIELDL
P61221 Y594 Sugiyama ABCE1 RLI RNASEL1 RNASELI RNS4I OK/SW-cl.40 RPRINKLNsIKDVEQKKsGNyFFLDD_______________
P61247 S263 Sugiyama RPS3A FTE1 MFTL GDEtGAKVERADGyEPPVQEsV___________________
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61313 S97 Sugiyama RPL15 EC45 TCBAP0781 KGAtyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLN
P61353 S34 Sugiyama RPL27 LAGRYSGRKAVIVKNIDDGtsDRPysHALVAGIDRyPRKVT
P61353 T33 Sugiyama RPL27 VLAGRYSGRKAVIVKNIDDGtsDRPysHALVAGIDRyPRKV
P61353 Y38 Sugiyama RPL27 YSGRKAVIVKNIDDGtsDRPysHALVAGIDRyPRKVTAAMG
P61604 T45 Sugiyama HSPE1 TVTKGGIMLPEKSQGKVLQAtVVAVGsGsKGKGGEIQPVsV
P61956 S28 Sugiyama SUMO2 SMT3B SMT3H2 EGVKtENNDHINLKVAGQDGsVVQFKIKRHTPLSKLMKAYC
P61978 S401 Sugiyama HNRNPK HNRPK GDLGGPIIttQVtIPKDLAGsIIGKGGQRIKQIRHEsGAsI
P61978 T70 Sugiyama HNRNPK HNRPK QSKNAGAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsI
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62263 S70 Sugiyama RPS14 PRO2640 KETICRVTGGMKVKADRDEssPyAAMLAAQDVAQRCKELGI
P62266 S45 Sugiyama RPS23 KQYKKAHLGtALKANPFGGAsHAKGIVLEKVGVEAKQPNSA
P62273 S9 Sugiyama RPS29 ____________MGHQQLyWsHPRKFGQGSRSCRVCSNRHG
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280 T28 Sugiyama RPS11 RAyQKQPtIFQNKKRVLLGEtGKEKLPRYYKNIGLGFKtPK
P62280 T54 Sugiyama RPS11 PRYYKNIGLGFKtPKEAIEGtyIDKKCPFTGNVsIRGRILs
P62316 S30 Sugiyama SNRPD2 SNRPD1 EMtPEELQKREEEEFNtGPLsVLtQsVKNNtQVLINCRNNK
P62316 S35 Sugiyama SNRPD2 SNRPD1 ELQKREEEEFNtGPLsVLtQsVKNNtQVLINCRNNKKLLGR
P62316 T26 Sugiyama SNRPD2 SNRPD1 KPKsEMtPEELQKREEEEFNtGPLsVLtQsVKNNtQVLINC
P62424 T84 Sugiyama RPL7A SURF-3 SURF3 QRQRAILyKRLKVPPAINQFtQALDRQTAtQLLKLAHKYRP
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 S62 Sugiyama ACTA2 ACTSA ACTVS GIG46 HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P62736 T251 Sugiyama ACTA2 ACTSA ACTVS GIG46 tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P62736 Y242 Sugiyama ACTA2 ACTSA ACTVS GIG46 ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62750 T126 Sugiyama RPL23A KHQIKQAVKKLyDIDVAKVNtLIRPDGEKKAYVRLAPDyDA
P62753 S148 Sugiyama RPS6 OK/SW-cl.2 tVPRRLGPKRASRIRKLFNLsKEDDVRQyVVRKPLNKEGKK
P62753 T127 Sugiyama RPS6 OK/SW-cl.2 SVLNLVIVKKGEKDIPGLtDttVPRRLGPKRASRIRKLFNL
P62753 T128 Sugiyama RPS6 OK/SW-cl.2 VLNLVIVKKGEKDIPGLtDttVPRRLGPKRASRIRKLFNLs
P62807 S39 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA
P62826 T66 Sugiyama RAN ARA24 OK/SW-cl.81 EVHPLVFHTNRGPIKFNVWDtAGQEKFGGLRDGYYIQAQCA
P62829 S115 Sugiyama RPL23 FLYFEDNAGVIVNNKGEMKGsAItGPVAKECADLWPRIASN
P62829 T118 Sugiyama RPL23 FEDNAGVIVNNKGEMKGsAItGPVAKECADLWPRIASNAGs
P62851 S74 Sugiyama RPS25 tyDKLCKEVPNYKLItPAVVsERLKIRGSLARAALQELLsK
P62857 S39 Sugiyama RPS28 GRtGsQGQCtQVRVEFMDDtsRsIIRNVKGPVREGDVLtLL
P62857 S61 Sugiyama RPS28 sIIRNVKGPVREGDVLtLLEsEREARRLR____________
P62857 T38 Sugiyama RPS28 LGRtGsQGQCtQVRVEFMDDtsRsIIRNVKGPVREGDVLtL
P62857 T57 Sugiyama RPS28 DtsRsIIRNVKGPVREGDVLtLLEsEREARRLR________
P62899 S15 Sugiyama RPL31 ______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62899 T107 Sugiyama RPL31 RLSRKRNEDEDsPNKLytLVtyVPVttFKNLQtVNVDEN__
P62899 T113 Sugiyama RPL31 NEDEDsPNKLytLVtyVPVttFKNLQtVNVDEN________
P62899 T22 Sugiyama RPL31 APAKKGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRA
P62899 T26 Sugiyama RPL31 KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62899 Y108 Sugiyama RPL31 LSRKRNEDEDsPNKLytLVtyVPVttFKNLQtVNVDEN___
P62906 S113 Sugiyama RPL10A NEDD6 LNKNKKLVKKLAKKyDAFLAsEsLIKQIPRILGPGLNKAGK
P62906 S115 Sugiyama RPL10A NEDD6 KNKKLVKKLAKKyDAFLAsEsLIKQIPRILGPGLNKAGKFP
P62913 S51 Sugiyama RPL11 DRLtRAAKVLEQLtGQtPVFsKARyTVRsFGIRRNEKIAVH
P62913 T44 Sugiyama RPL11 ICVGEsGDRLtRAAKVLEQLtGQtPVFsKARyTVRsFGIRR
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 S138 Sugiyama RPL8 EKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVI
P62917 S14 Sugiyama RPL8 _______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917 T143 Sugiyama RPL8 RGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVISSANR
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62942 T7 Sugiyama FKBP1A FKBP1 FKBP12 ______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P62979 S123 Sugiyama RPS27A UBA80 UBCEP1 LKYYKVDENGKIsRLRRECPsDECGAGVFMAsHFDRHyCGK
P62979 S134 Sugiyama RPS27A UBA80 UBCEP1 IsRLRRECPsDECGAGVFMAsHFDRHyCGKCCLtyCFNKPE
P63104 S145 Sugiyama YWHAZ YYRyLAEVAAGDDKKGIVDQsQQAyQEAFEIsKKEMQPTHP
P63104 S156 Sugiyama YWHAZ DDKKGIVDQsQQAyQEAFEIsKKEMQPTHPIRLGLALNFSV
P63104 S28 Sugiyama YWHAZ QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63173 T14 Sugiyama RPL38 _______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63220 S65 Sugiyama RPS21 RFNGQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF__
P63220 S68 Sugiyama RPS21 GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S365 Sugiyama ACTG1 ACTG ILAsLstFQQMWISKQEyDEsGPsIVHRKCF__________
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 S60 Sugiyama ACTG1 ACTG HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P63261 T249 Sugiyama ACTG1 ACTG tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P63261 Y240 Sugiyama ACTG1 ACTG ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 S61 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P63267 T250 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P63267 Y241 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P67809 S102 Sugiyama YBX1 NSEP1 YB1 EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P67809 S136 Sugiyama YBX1 NSEP1 YB1 GEKGAEAANVtGPGGVPVQGsKYAADRNHYRRYPRRRGPPR
P67809 S209 Sugiyama YBX1 NSEP1 YB1 RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P67809 T108 Sugiyama YBX1 NSEP1 YB1 QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P67809 Y99 Sugiyama YBX1 NSEP1 YB1 DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 S62 Sugiyama ACTC1 ACTC HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68032 T251 Sugiyama ACTC1 ACTC tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68032 Y242 Sugiyama ACTC1 ACTC ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 S62 Sugiyama ACTA1 ACTA HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68133 T251 Sugiyama ACTA1 ACTA tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68133 Y242 Sugiyama ACTA1 ACTA ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P83731 S86 Sugiyama RPL24 EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731 T52 Sugiyama RPL24 LNAKCEsAFLSKRNPRQINWtVLyRRKHKKGQsEEIQKKRT
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P83731 Y55 Sugiyama RPL24 KCEsAFLSKRNPRQINWtVLyRRKHKKGQsEEIQKKRTRRA
P84098 S12 Sugiyama RPL19 _________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
P84098 S122 Sugiyama RPL19 LRRLLRRYRESKKIDRHMyHsLyLKVKGNVFKNKRILMEHI
P84098 S13 Sugiyama RPL19 ________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEIA
P84098 S37 Sugiyama RPL19 CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
P84098 T29 Sugiyama RPL19 RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
P84098 Y124 Sugiyama RPL19 RLLRRYRESKKIDRHMyHsLyLKVKGNVFKNKRILMEHIHK
Q00839 S585 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 KFIEIAARKKRNFILDQtNVsAAAQRRKMCLFAGFQRKAVV
Q00839 T582 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 CLGKFIEIAARKKRNFILDQtNVsAAAQRRKMCLFAGFQRK
Q01082 S1388 Sugiyama SPTBN1 SPTB2 TTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSDDy
Q01105 S161 Sugiyama SET FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q01546 S196 Sugiyama KRT76 KRT2B KRT2P IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q02818 S378 Sugiyama NUCB1 NUC EAELNAKAQRLsQETEALGRsQGRLEAQKRELQQAVLHMEQ
Q02878 T213 Sugiyama RPL6 TXREB1 FVIAtsTKIDISNVKIPKHLtDAyFKKKKLRKPRHQEGEIF
Q02878 Y216 Sugiyama RPL6 TXREB1 AtsTKIDISNVKIPKHLtDAyFKKKKLRKPRHQEGEIFDtE
Q06323 S55 Sugiyama PSME1 IFI5111 KKIsELDAFLKEPALNEANLsNLKAPLDIPVPDPVKEKEKE
Q06830 S152 Sugiyama PRDX1 PAGA PAGB TDPX2 IIDDKGILRQItVNDLPVGRsVDEtLRLVQAFQFtDKHGEV
Q06830 T156 Sugiyama PRDX1 PAGA PAGB TDPX2 KGILRQItVNDLPVGRsVDEtLRLVQAFQFtDKHGEVCPAG
Q07020 S140 Sugiyama RPL18 ILtFDQLALDsPKGCGtVLLsGPRKGREVYRHFGKAPGtPH
Q07020 T136 Sugiyama RPL18 AGGKILtFDQLALDsPKGCGtVLLsGPRKGREVYRHFGKAP
Q07020 T39 Sugiyama RPL18 KSQDIyLRLLVKLYRFLARRtNstFNQVVLKRLFMSRtNRP
Q07020 T42 Sugiyama RPL18 DIyLRLLVKLYRFLARRtNstFNQVVLKRLFMSRtNRPPLs
Q13243 S153 Sugiyama SRSF5 HRS SFRS5 SRP40 EVTFADAHRPKLNEGVVEFAsYGDLKNAIEKLSGKEINGRK
Q13283 S362 Sugiyama G3BP1 G3BP LFIGNLPHEVDKSELKDFFQsyGNVVELRINsGGKLPNFGF
Q13283 S38 Sugiyama G3BP1 G3BP QyytLLNQAPDMLHRFYGKNssyVHGGLDsNGKPADAVyGQ
Q13283 S47 Sugiyama G3BP1 G3BP PDMLHRFYGKNssyVHGGLDsNGKPADAVyGQKEIHRKVMs
Q13310 T191 Sugiyama PABPC4 APP1 PABP4 GRFKSRKEREAELGAKAKEFtNVyIKNFGEEVDDEsLKELF
Q13310 Y194 Sugiyama PABPC4 APP1 PABP4 KSRKEREAELGAKAKEFtNVyIKNFGEEVDDEsLKELFsQF
Q13428 S1410 Sugiyama TCOF1 AKRDKASGDVKEKKGKGsLGsQGAKDEPEEELQKGMGTVEG
Q13509 S115 Sugiyama TUBB3 TUBB4 SGAGNNWAKGHytEGAELVDsVLDVVRKECENCDCLQGFQL
Q13509 S75 Sugiyama TUBB3 TUBB4 SSHKYVPRAILVDLEPGtMDsVRSGAFGHLFRPDNFIFGQS
Q13561 S391 Sugiyama DCTN2 DCTN50 LTQVQTTMRENLATVEGNFAsIDERMKKLGK__________
Q13601 S284 Sugiyama KRR1 HRB2 KEYtPFPPPQPESQIDKELAsGEyFLKANQKKRQKMEAIKA
Q13765 S117 Sugiyama NACA HSD48 RKSKNILFVITKPDVYKSPAsDtyIVFGEAKIEDLsQQAQL
Q13765 S132 Sugiyama NACA HSD48 YKSPAsDtyIVFGEAKIEDLsQQAQLAAAEKFKVQGEAVsN
Q13765 S186 Sugiyama NACA HSD48 sEEEEVDEtGVEVKDIELVMsQANVsRAKAVRALKNNSNDI
Q13765 S191 Sugiyama NACA HSD48 VDEtGVEVKDIELVMsQANVsRAKAVRALKNNSNDIVNAIM
Q13765 T119 Sugiyama NACA HSD48 SKNILFVITKPDVYKSPAsDtyIVFGEAKIEDLsQQAQLAA
Q13765 Y120 Sugiyama NACA HSD48 KNILFVITKPDVYKSPAsDtyIVFGEAKIEDLsQQAQLAAA
Q13885 S115 Sugiyama TUBB2A TUBB2 sGAGNNWAKGHytEGAELVDsVLDVVRKESESCDCLQGFQL
Q13885 S75 Sugiyama TUBB2A TUBB2 AGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q14103 S271 Sugiyama HNRNPD AUF1 HNRPD KCEIKVAMSKEQyQQQQQWGsRGGFAGRARGRGGGPSQNWN
Q14151 S613 Sugiyama SAFB2 KIAA0138 ERSSKSQDRKSESKEKRDILsFDKIKEQRERERQRQREREI
Q14152 S584 Sugiyama EIF3A EIF3S10 KIAA0139 EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14157 S859 Sugiyama UBAP2L KIAA0144 NICE4 FPtPttPLtGRDGsLAsNPysGDLtKFGRGDASSPAPATTL
Q14157 T23 Sugiyama UBAP2L KIAA0144 NICE4 TSVGTNRARGNWEQPQNQNQtQHKQRPQATAEQIRLAQMIS
Q14192 T234 Sugiyama FHL2 DRAL SLIM3 CDLyAKKCAGCTNPISGLGGtKyIsFEERQWHNDCFNCKKC
Q14240 S79 Sugiyama EIF4A2 DDX2B EIF4F IQQRAIIPCIKGyDVIAQAQsGtGKTATFAISILQQLEIEF
Q14247 S117 Sugiyama CTTN EMS1 KsAVGHEyQSKLsKHCsQVDsVRGFGGKFGVQMDRVDQsAV
Q14444 T303 Sugiyama CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105 YTEQSEVESTEYVNRQFMAEtQFtsGEKEQVDEWTVETVEV
Q14568 S53 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14677 S166 Sugiyama CLINT1 ENTH EPN4 EPNR KIAA0171 REERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSKWDE
Q14847 S99 Sugiyama LASP1 MLN50 ELQsQVRYKEEFEKNKGKGFsVVADtPELQRIKKTQDQIsN
Q14978 S637 Sugiyama NOLC1 KIAA0035 NS5ATP13 GEKRAssPFRRVREEEIEVDsRVADNsFDAKRGAAGDWGER
Q14978 S643 Sugiyama NOLC1 KIAA0035 NS5ATP13 sPFRRVREEEIEVDsRVADNsFDAKRGAAGDWGERANQVLK
Q14CN4 S138 Sugiyama KRT72 K6IRS2 KB35 KRT6 KRT6IRS2 IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15056 S66 Sugiyama EIF4H KIAA0038 WBSCR1 WSCR1 VGNLPFNTVQGDIDAIFKDLsIRsVRLVRDKDTDKFKGFCy
Q15056 S69 Sugiyama EIF4H KIAA0038 WBSCR1 WSCR1 LPFNTVQGDIDAIFKDLsIRsVRLVRDKDTDKFKGFCyVEF
Q15084 S169 Sugiyama PDIA6 ERP5 P5 TXNDC7 GKQGRSDsSSKKDVIELtDDsFDKNVLDSEDVWMVEFYAPW
Q15185 S118 Sugiyama PTGES3 P23 TEBP WLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGDEDVDL
Q15293 T100 Sugiyama RCN1 RCN sKERLGKIVDRIDNDGDGFVttEELKtWIKRVQKRyIFDNV
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q3SY84 S143 Sugiyama KRT71 K6IRS1 KB34 KRT6IRS1 IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q562R1 T107 Sugiyama ACTBL2 WYHTFYNELRVAPDEHPILLtEAPLNPKINREKMTQIMFEA
Q562R1 T250 Sugiyama ACTBL2 RAAAssSPERsyELPDGQVItIGNERFRCPEAIFQPSFLGI
Q562R1 Y241 Sugiyama ACTBL2 ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q58FF7 S370 Sugiyama HSP90AB3P HSP90BC KETQKSTYYITGESKEQVANsAFVERVRKQGFEVVYMTEPI
Q58FF7 S405 Sugiyama HSP90AB3P HSP90BC YMTEPIDEYCVQQLKEFDGKsLVsVtKEGLELPEDEEEKKK
Q58FF7 S408 Sugiyama HSP90AB3P HSP90BC EPIDEYCVQQLKEFDGKsLVsVtKEGLELPEDEEEKKKMEE
Q58FF8 S305 Sugiyama HSP90AB2P HSP90BB RVVYMTEPIDGYQLKEFDGKsLVsVtKEGLELPEDGEEKKR
Q58FF8 S308 Sugiyama HSP90AB2P HSP90BB YMTEPIDGYQLKEFDGKsLVsVtKEGLELPEDGEEKKRMEE
Q5QNW6 S39 Sugiyama H2BC18 HIST2H2BF VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q5T3I0 S272 Sugiyama GPATCH4 GPATC4 VsDEREGTTKGNEKEDAAGtsGLGELNSREQtNQSLRKGKK
Q5XKE5 S155 Sugiyama KRT79 K6L KB38 KRT6L IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q6EEV6 S28 Sugiyama SUMO4 SMT3H4 EEVKTENNNHINLKVAGQDGsVVQFKIKRQTPLSKLMKAYC
Q6PEY2 T73 Sugiyama TUBA3E FsEtGAGKHVPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLI
Q6PEY2 T80 Sugiyama TUBA3E KHVPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLITGKEDAA
Q6PEY2 T82 Sugiyama TUBA3E VPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLITGKEDAASN
Q6PEY2 Y83 Sugiyama TUBA3E PRAVFVDLEPtVVDEVRtGtyRQLFHPEQLITGKEDAASNY
Q6S8J3 S1065 Sugiyama POTEE A26C1A POTE2 ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6S8J3 T949 Sugiyama POTEE A26C1A POTE2 tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q6S8J3 Y940 Sugiyama POTEE A26C1A POTE2 ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q6ZMR3 S167 Sugiyama LDHAL6A LDHL2 AWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIHSESCHG
Q71UM5 S78 Sugiyama RPS27L GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q7KZI7 S479 Sugiyama MARK2 EMK1 PGLERKKttPtPstNSVLststNRsRNsPLLERAsLGQAsI
Q7RTS7 S153 Sugiyama KRT74 K6IRS4 KB37 KRT5C KRT6IRS4 IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z417 S652 Sugiyama NUFIP2 KIAA1321 PIG1 NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z4V5 S369 Sugiyama HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 EKERRRERADRGEAERGsGGssGDELREDDEPVKKRGRKGR
Q7Z794 S177 Sugiyama KRT77 KRT1B IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86SG6 T162 EPSD NEK8 JCK NEK12A VVKIGDFGISKILSSKSKAYtVVGTPCYISPELCEGKPYNQ
Q86U42 S235 Sugiyama PABPN1 PAB2 PABP2 FAyIEFSDKEsVRTSLALDEsLFRGRQIKVIPKRTNRPGIS
Q86V81 S145 Sugiyama ALYREF ALY BEF THOC4 LFAEFGtLKKAAVHYDRsGRsLGtADVHFERKADALKAMKQ
Q86V81 S8 Sugiyama ALYREF ALY BEF THOC4 _____________MADKMDMsLDDIIKLNRSQRGGRGGGRG
Q86Y46 S145 Sugiyama KRT73 K6IRS3 KB36 KRT6IRS3 IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8N6H7 S368 Sugiyama ARFGAP2 ZNF289 Nbla10535 VGTFASGPPKYKDNPFsLGEsFGsRWDTDAAWGMDRVEEKE
Q8NBS9 S255 Sugiyama TXNDC5 TLP46 UNQ364/PRO700 EHSETVKIGKVDCtQHyELCsGNQVRGyPtLLWFRDGKKVD
Q8NHV4 S377 SIGNOR|EPSD|PSP NEDD1 MTSAMGKGTVAVQEKAGLPRsINTDtLSKEtDsGKNQDFss
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8TD19 S29 iPTMNet|EPSD NEK9 KIAA1995 NEK8 NERCC RHCDsINSDFGSEsGGCGDssPGPSASQGPRAGGGAAEQEE
Q8TD19 S332 iPTMNet|EPSD NEK9 KIAA1995 NEK8 NERCC RREMEEKVTLLNAPTKRPRsstVtEAPIAVVTSRTSEVYVW
Q8TD19 S735 iPTMNet|EPSD NEK9 KIAA1995 NEK8 NERCC CRGWHTILIVEKVLNSKTIRsNssGLsIGtVFQSssPGGGG
Q8TD19 S76 Sugiyama NEK9 KIAA1995 NEK8 NERCC RVLGRGAFGEAtLyRRTEDDsLVVWKEVDLTRLSEKERRDA
Q8TD19 S855 Sugiyama NEK9 KIAA1995 NEK8 NERCC FsEsEKDTLPyEELQGLKVAsEAPLEHKPQVEAssPRLNPA
Q8TD19 S868 iPTMNet|EPSD|Sugiyama NEK9 KIAA1995 NEK8 NERCC LQGLKVAsEAPLEHKPQVEAssPRLNPAVtCAGKGtPLtPP
Q8TD19 S869 Sugiyama NEK9 KIAA1995 NEK8 NERCC QGLKVAsEAPLEHKPQVEAssPRLNPAVtCAGKGtPLtPPA
Q8TD19 S944 SIGNOR|EPSD|PSP|Sugiyama NEK9 KIAA1995 NEK8 NERCC FTQLQKLNKKLEGGQQVGMHsKGTQTAKEEMEMDPKPDLDS
Q8TD19 T210 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP NEK9 KIAA1995 NEK8 NERCC IKLGDYGLAKKLNSEYSMAEtLVGtPYYMSPELCQGVKYNF
Q8TD19 T333 iPTMNet|EPSD|Sugiyama NEK9 KIAA1995 NEK8 NERCC REMEEKVTLLNAPTKRPRsstVtEAPIAVVTSRTSEVYVWG
Q8TD19 T335 iPTMNet|EPSD NEK9 KIAA1995 NEK8 NERCC MEEKVTLLNAPTKRPRsstVtEAPIAVVTSRTSEVYVWGGG
Q8TD19 T358 iPTMNet|EPSD NEK9 KIAA1995 NEK8 NERCC PIAVVTSRTSEVYVWGGGKStPQKLDVIKSGCSARQVCAGN
Q8TD19 T67 Sugiyama NEK9 KIAA1995 NEK8 NERCC QEELHyIPIRVLGRGAFGEAtLyRRTEDDsLVVWKEVDLTR
Q8TD19 T877 Sugiyama NEK9 KIAA1995 NEK8 NERCC APLEHKPQVEAssPRLNPAVtCAGKGtPLtPPACACSSLQV
Q8TD19 T886 iPTMNet|EPSD NEK9 KIAA1995 NEK8 NERCC EAssPRLNPAVtCAGKGtPLtPPACACSSLQVEVERLQGLV
Q8TD19 Y52 Sugiyama NEK9 KIAA1995 NEK8 NERCC PSASQGPRAGGGAAEQEELHyIPIRVLGRGAFGEAtLyRRT
Q8TD19 Y69 Sugiyama NEK9 KIAA1995 NEK8 NERCC ELHyIPIRVLGRGAFGEAtLyRRTEDDsLVVWKEVDLTRLS
Q8TDX7 S195 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP NEK7 VKLGDLGLGRFFssKttAAHsLVGtPyYMsPERIHENGYNF
Q92522 T101 Sugiyama H1-10 H1FX DQQNGRTYLKYSIKALVQNDtLLQVKGTGANGSFKLNRKKL
Q92890 S299 Sugiyama UFD1 UFD1L KKVEEDEAGGRFVAFsGEGQsLRKKGRKP____________
Q93079 S39 Sugiyama H2BC9 H2BFJ HIST1H2BH VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q96HC4 T80 Sugiyama PDLIM5 ENH L9 GMTHLEAQNKIKGCTGsLNMtLQRAsAAPKPEPVPVQKGEP
Q99848 S270 Sugiyama EBNA1BP2 EBP2 FGGKKKGSKWNtREsyDDVssFRAKTAHGRGLKRPGKKGSN
Q99877 S39 Sugiyama H2BC15 H2BFD HIST1H2BN VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99879 S39 Sugiyama H2BC14 H2BFE HIST1H2BM INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99880 S39 Sugiyama H2BC13 H2BFC HIST1H2BL VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q9BQ39 S140 Sugiyama DDX50 KSSDNKLEETLTREQKEGAFsNFPIsEEtIKLLKGRGVTYL
Q9BQ39 S145 Sugiyama DDX50 KLEETLTREQKEGAFsNFPIsEEtIKLLKGRGVTYLFPIQV
Q9BVA1 S115 Sugiyama TUBB2B sGAGNNWAKGHytEGAELVDsVLDVVRKESESCDCLQGFQL
Q9BVA1 S75 Sugiyama TUBB2B tGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q9BX40 S349 Sugiyama LSM14B C20orf40 FAM61B RAP55B SSRRTTWAEERKLNtEtFGVsGRFLRGRSSRGGFRGGRGNG
Q9BX40 T345 Sugiyama LSM14B C20orf40 FAM61B RAP55B ELKTSSRRTTWAEERKLNtEtFGVsGRFLRGRSSRGGFRGG
Q9BYX7 S365 Sugiyama POTEKP ACTBL3 FKSG30 ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9BYX7 T249 Sugiyama POTEKP ACTBL3 FKSG30 MAASSSSVEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q9BYX7 Y240 Sugiyama POTEKP ACTBL3 FKSG30 ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9BZI7 S166 Sugiyama UPF3B RENT3B UPF3X KRDTKVGtIDDDPEyRKFLEsyAtDNEKMTstPEtLLEEIE
Q9GZQ8 T50 SIGNOR|PSP MAP1LC3B MAP1ALC3 KIPVIIERYKGEKQLPVLDKtKFLVPDHVNMSELIKIIRRR
Q9H444 T85 Sugiyama CHMP4B C20orf178 SHAX1 ALQALKRKKRYEKQLAQIDGtLstIEFQREALENANtNtEV
Q9H444 T88 Sugiyama CHMP4B C20orf178 SHAX1 ALKRKKRYEKQLAQIDGtLstIEFQREALENANtNtEVLKN
Q9H788 S159 Sugiyama SH2D4A PPP1R38 SH2A NQQtKDIWKKVAEKEELEQGsRPAPTLEEEKIRSLSSSSRN
Q9HC98 S206 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP NEK6 VKLGDLGLGRFFssEttAAHsLVGtPYYMSPERIHENGYNF
Q9NQ39 S157 Sugiyama RPS10P5 RPS10L TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9NQ39 T159 Sugiyama RPS10P5 RPS10L RRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ___
Q9NR30 S189 Sugiyama DDX21 EEsNsEIEQEIPVEQKEGAFsNFPIsEEtIKLLKGRGVTFL
Q9NR30 S194 Sugiyama DDX21 EIEQEIPVEQKEGAFsNFPIsEEtIKLLKGRGVTFLFPIQA
Q9NSB2 S178 Sugiyama KRT84 KRTHB4 AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9NZZ3 S86 Sugiyama CHMP5 C9orf83 SNF7DC2 CGI-34 HSPC177 PNAS-114 PNAS-2 LRVLKQKRMYEQQRDNLAQQsFNMEQANytIQsLKDTKTTV
Q9NZZ3 T95 Sugiyama CHMP5 C9orf83 SNF7DC2 CGI-34 HSPC177 PNAS-114 PNAS-2 YEQQRDNLAQQsFNMEQANytIQsLKDTKTTVDAMKLGVKE
Q9NZZ3 Y94 Sugiyama CHMP5 C9orf83 SNF7DC2 CGI-34 HSPC177 PNAS-114 PNAS-2 MYEQQRDNLAQQsFNMEQANytIQsLKDTKTTVDAMKLGVK
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UI15 T190 Sugiyama TAGLN3 NP25 GQNVIGLQMGSNKGAsQAGMtGyGMPRQIM___________
Q9UI15 Y192 Sugiyama TAGLN3 NP25 NVIGLQMGSNKGAsQAGMtGyGMPRQIM_____________
Q9UII2 S39 Sugiyama ATP5IF1 ATPI ATPIF1 TMQARGFGsDQSENVDRGAGsIREAGGAFGKREQAEEERyF
Q9UKX7 S52 Sugiyama NUP50 NPAP60L PRO1146 EEVLKNRAIKKAKRRNVGFEsDtGGAFKGFKGLVVPSGGGR
Q9UPQ9 S1086 Sugiyama TNRC6B KIAA1093 FSNMGLLSQTEDNPSSKMDLsVGSLSDKKFDVDKRAMNLGD
Q9UQ35 S1653 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 PRRSRSGSSSKGRGPsPEGssstEssPEHPPKSRTARRGsR
Q9UQ35 S2459 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 LLPPAQDQPRsPVPsAFsDQsRCLIAQTTPVAGSQSLSSGA
Q9UQ35 S2692 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9Y2B0 S115 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 QIDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKF
Q9Y2B0 S55 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDELEWEIAQVDPKKTIQMGsFRINPDGsQsVVEVPyARsE
Q9Y2B0 S63 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 AQVDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLE
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2W1 T227 Sugiyama THRAP3 BCLAF2 TRAP150 sGGtsQDTKAsEssKPWPDAtyGtGsAsRAsAVsELsPRER
Q9Y2W1 T230 Sugiyama THRAP3 BCLAF2 TRAP150 tsQDTKAsEssKPWPDAtyGtGsAsRAsAVsELsPRERsPA
Q9Y3U8 S91 Sugiyama RPL36 KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Q9Y3U8 Y53 Sugiyama RPL36 LTKHTKFVRDMIREVCGFAPyERRAMELLKVSKDKRALKFI
Q9Y5L4 S57 Sugiyama TIMM13 TIM13B TIMM13A TIMM13B ELLQRMTDKCFRKCIGKPGGsLDNSEQKCIAMCMDRyMDAW
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 9.534484e-11 10.021 1 0
Cell Cycle, Mitotic R-HSA-69278 9.846102e-11 10.007 1 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 5.682269e-10 9.245 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.488732e-09 8.827 0 0
Interleukin-12 signaling R-HSA-9020591 6.428402e-09 8.192 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 8.660099e-09 8.062 1 1
Apoptotic cleavage of cellular proteins R-HSA-111465 1.177490e-08 7.929 0 0
Apoptotic execution phase R-HSA-75153 1.862810e-08 7.730 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 4.035060e-08 7.394 0 0
Interleukin-12 family signaling R-HSA-447115 7.691514e-08 7.114 0 0
HSF1-dependent transactivation R-HSA-3371571 1.218367e-07 6.914 0 0
M Phase R-HSA-68886 1.218208e-07 6.914 1 0
Mitotic Prometaphase R-HSA-68877 1.688891e-07 6.772 1 0
Cellular responses to stress R-HSA-2262752 1.746770e-07 6.758 0 0
Mitotic Anaphase R-HSA-68882 2.485003e-07 6.605 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.901967e-07 6.537 0 0
Cellular responses to stimuli R-HSA-8953897 2.809702e-07 6.551 0 0
Axon guidance R-HSA-422475 3.396289e-07 6.469 0 0
Signal Transduction R-HSA-162582 4.070341e-07 6.390 0 0
Cellular response to heat stress R-HSA-3371556 5.282307e-07 6.277 0 0
Separation of Sister Chromatids R-HSA-2467813 6.975832e-07 6.156 0 0
Nervous system development R-HSA-9675108 6.782215e-07 6.169 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.235395e-06 5.908 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.340759e-06 5.873 0 0
Post NMDA receptor activation events R-HSA-438064 1.347442e-06 5.870 0 0
Attenuation phase R-HSA-3371568 1.966063e-06 5.706 0 0
EPH-Ephrin signaling R-HSA-2682334 2.214147e-06 5.655 0 0
Transport of connexons to the plasma membrane R-HSA-190872 2.346265e-06 5.630 0 0
Kinesins R-HSA-983189 5.856841e-06 5.232 0 0
Recycling pathway of L1 R-HSA-437239 8.787213e-06 5.056 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 9.128249e-06 5.040 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 9.415360e-06 5.026 0 0
Selective autophagy R-HSA-9663891 9.961177e-06 5.002 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.075912e-05 4.968 0 0
L1CAM interactions R-HSA-373760 1.067805e-05 4.972 0 0
Semaphorin interactions R-HSA-373755 1.287166e-05 4.890 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.522375e-05 4.817 0 0
HSF1 activation R-HSA-3371511 1.592005e-05 4.798 0 0
Aggrephagy R-HSA-9646399 1.911146e-05 4.719 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.159559e-05 4.666 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.238164e-05 4.650 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.321601e-05 4.634 0 0
RAF activation R-HSA-5673000 2.542489e-05 4.595 0 0
Apoptosis R-HSA-109581 3.126052e-05 4.505 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.863687e-05 4.413 0 0
PKR-mediated signaling R-HSA-9833482 4.372658e-05 4.359 0 0
Programmed Cell Death R-HSA-5357801 5.292430e-05 4.276 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 5.715747e-05 4.243 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 6.503919e-05 4.187 0 0
Amplification of signal from the kinetochores R-HSA-141424 6.476425e-05 4.189 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 6.476425e-05 4.189 0 0
Mitotic Spindle Checkpoint R-HSA-69618 6.931159e-05 4.159 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 8.075672e-05 4.093 0 0
Membrane Trafficking R-HSA-199991 8.211478e-05 4.086 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 9.835155e-05 4.007 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 9.963189e-05 4.002 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.003937e-04 3.998 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.013943e-04 3.994 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.119602e-04 3.951 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.389177e-04 3.857 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.389177e-04 3.857 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.389177e-04 3.857 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.310901e-04 3.882 0 0
Signaling by RAS mutants R-HSA-6802949 1.389177e-04 3.857 0 0
Signaling by ALK in cancer R-HSA-9700206 1.310901e-04 3.882 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.504454e-04 3.823 0 0
Autophagy R-HSA-9612973 1.640094e-04 3.785 0 0
G2/M Transition R-HSA-69275 2.422854e-04 3.616 0 0
Regulation of KIT signaling R-HSA-1433559 2.560348e-04 3.592 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.658542e-04 3.575 0 0
Gap junction trafficking and regulation R-HSA-157858 2.887961e-04 3.539 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.933322e-04 3.533 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.117807e-04 3.506 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.234334e-04 3.490 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 3.448293e-04 3.462 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.588421e-04 3.445 0 0
Cell-extracellular matrix interactions R-HSA-446353 4.008082e-04 3.397 0 0
Macroautophagy R-HSA-1632852 4.039792e-04 3.394 0 0
Signaling by VEGF R-HSA-194138 4.178553e-04 3.379 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 4.324062e-04 3.364 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 5.277450e-04 3.278 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 5.030571e-04 3.298 0 0
Gap junction trafficking R-HSA-190828 5.535839e-04 3.257 0 0
Cell-Cell communication R-HSA-1500931 5.862120e-04 3.232 0 0
Cellular Senescence R-HSA-2559583 6.142663e-04 3.212 0 0
Long-term potentiation R-HSA-9620244 8.170959e-04 3.088 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 8.189494e-04 3.087 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 8.231694e-04 3.085 0 0
Notch-HLH transcription pathway R-HSA-350054 9.653003e-04 3.015 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.023040e-03 2.990 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.048165e-03 2.980 0 0
Cell junction organization R-HSA-446728 1.077242e-03 2.968 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.079417e-03 2.967 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.097631e-03 2.960 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.127630e-03 2.948 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.211008e-03 2.917 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.178514e-03 2.929 0 0
Striated Muscle Contraction R-HSA-390522 1.271348e-03 2.896 0 0
Signaling by Hippo R-HSA-2028269 1.296953e-03 2.887 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.342348e-03 2.872 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.587313e-03 2.799 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.495856e-03 2.825 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.609538e-03 2.793 0 0
Gap junction assembly R-HSA-190861 1.625575e-03 2.789 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.637760e-03 2.786 0 0
MHC class II antigen presentation R-HSA-2132295 1.700716e-03 2.769 0 0
MAPK family signaling cascades R-HSA-5683057 1.986068e-03 2.702 0 0
Oncogene Induced Senescence R-HSA-2559585 2.059121e-03 2.686 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.329612e-03 2.633 0 0
Cell Cycle Checkpoints R-HSA-69620 2.522125e-03 2.598 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.542899e-03 2.595 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 2.552521e-03 2.593 0 0
PECAM1 interactions R-HSA-210990 2.572130e-03 2.590 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.611668e-03 2.583 0 0
Signaling by ERBB2 R-HSA-1227986 2.636338e-03 2.579 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.861452e-03 2.543 0 0
Cytokine Signaling in Immune system R-HSA-1280215 2.902369e-03 2.537 0 0
Co-stimulation by CD28 R-HSA-389356 3.006423e-03 2.522 0 0
Metalloprotease DUBs R-HSA-5689901 3.038767e-03 2.517 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.218098e-03 2.492 0 0
Chaperonin-mediated protein folding R-HSA-390466 3.293079e-03 2.482 0 0
Nucleosome assembly R-HSA-774815 3.764680e-03 2.424 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.764680e-03 2.424 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 3.922745e-03 2.406 0 0
Regulation of TP53 Activity R-HSA-5633007 3.860934e-03 2.413 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.727652e-03 2.429 0 0
Intracellular signaling by second messengers R-HSA-9006925 4.142082e-03 2.383 0 0
Nef and signal transduction R-HSA-164944 4.144008e-03 2.383 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 4.178612e-03 2.379 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 4.610585e-03 2.336 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 4.610585e-03 2.336 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 4.610585e-03 2.336 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 4.610585e-03 2.336 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 4.610585e-03 2.336 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 4.610585e-03 2.336 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 4.610585e-03 2.336 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 4.610585e-03 2.336 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 4.610585e-03 2.336 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 4.610585e-03 2.336 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 4.610585e-03 2.336 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 4.556332e-03 2.341 0 0
mRNA Splicing R-HSA-72172 4.351759e-03 2.361 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 4.977197e-03 2.303 0 0
RAF/MAP kinase cascade R-HSA-5673001 5.564629e-03 2.255 0 0
Signaling by Interleukins R-HSA-449147 5.617413e-03 2.250 0 0
Mitotic Prophase R-HSA-68875 6.197410e-03 2.208 1 0
Integrin signaling R-HSA-354192 6.234607e-03 2.205 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 6.499845e-03 2.187 0 0
MECP2 regulates transcription factors R-HSA-9022707 6.805406e-03 2.167 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 6.805406e-03 2.167 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.685330e-03 2.175 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 6.303405e-03 2.200 0 0
Netrin-1 signaling R-HSA-373752 6.826203e-03 2.166 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 6.847606e-03 2.164 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 7.151714e-03 2.146 0 0
Protein folding R-HSA-391251 7.206072e-03 2.142 0 0
CD28 dependent Vav1 pathway R-HSA-389359 7.970981e-03 2.098 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 7.970981e-03 2.098 0 0
MAP2K and MAPK activation R-HSA-5674135 8.578773e-03 2.067 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 9.578806e-03 2.019 0 0
Diseases of DNA repair R-HSA-9675135 9.635386e-03 2.016 0 0
HDACs deacetylate histones R-HSA-3214815 9.883340e-03 2.005 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.110281e-02 1.955 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.110281e-02 1.955 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.052754e-02 1.978 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.052754e-02 1.978 0 0
CRMPs in Sema3A signaling R-HSA-399956 1.094754e-02 1.961 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.136073e-02 1.945 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.148419e-02 1.940 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.177575e-02 1.929 0 0
Signaling by SCF-KIT R-HSA-1433557 1.210942e-02 1.917 0 0
Chromatin organization R-HSA-4839726 1.284350e-02 1.891 0 0
Signaling by AXIN mutants R-HSA-4839735 1.316221e-02 1.881 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.316221e-02 1.881 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.467418e-02 1.833 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.443801e-02 1.840 0 0
Signaling by NOTCH R-HSA-157118 1.418602e-02 1.848 0 0
GPVI-mediated activation cascade R-HSA-114604 1.361069e-02 1.866 0 0
DCC mediated attractive signaling R-HSA-418885 1.467418e-02 1.833 0 0
Interferon Signaling R-HSA-913531 1.447561e-02 1.839 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.361104e-02 1.866 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.328462e-02 1.877 1 0
Chromatin modifying enzymes R-HSA-3247509 1.345105e-02 1.871 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.339343e-02 1.873 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.339343e-02 1.873 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.490075e-02 1.827 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.524043e-02 1.817 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 1.538615e-02 1.813 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.550277e-02 1.810 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.555000e-02 1.808 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.555000e-02 1.808 0 0
Cellular response to chemical stress R-HSA-9711123 1.585999e-02 1.800 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 1.809145e-02 1.743 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 1.809145e-02 1.743 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 1.809145e-02 1.743 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.754082e-02 1.756 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 1.802615e-02 1.744 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.802615e-02 1.744 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.802615e-02 1.744 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.802615e-02 1.744 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.802615e-02 1.744 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.802615e-02 1.744 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.808691e-02 1.743 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.658066e-02 1.780 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.814473e-02 1.741 0 0
FOXO-mediated transcription R-HSA-9614085 1.772954e-02 1.751 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.802615e-02 1.744 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.808691e-02 1.743 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.685552e-02 1.773 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.924557e-02 1.716 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.926092e-02 1.715 0 0
Cell-cell junction organization R-HSA-421270 2.063051e-02 1.685 0 0
NRAGE signals death through JNK R-HSA-193648 2.185112e-02 1.661 0 0
Signal attenuation R-HSA-74749 2.190652e-02 1.659 0 0
Receptor Mediated Mitophagy R-HSA-8934903 2.190652e-02 1.659 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.190652e-02 1.659 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.217059e-02 1.654 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 2.292891e-02 1.640 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.319586e-02 1.635 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.380786e-02 1.623 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.429331e-02 1.615 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.460191e-02 1.609 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.592678e-02 1.586 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.606055e-02 1.584 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 2.606055e-02 1.584 0 0
Diseases of Cellular Senescence R-HSA-9630747 2.910350e-02 1.536 0 0
Diseases of cellular response to stress R-HSA-9675132 2.910350e-02 1.536 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 2.910350e-02 1.536 0 0
Signaling by APC mutants R-HSA-4839744 2.988955e-02 1.524 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.988955e-02 1.524 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.988955e-02 1.524 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.988955e-02 1.524 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.914991e-02 1.535 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.954459e-02 1.530 0 0
ER to Golgi Anterograde Transport R-HSA-199977 2.697237e-02 1.569 0 0
HATs acetylate histones R-HSA-3214847 2.890835e-02 1.539 0 0
RMTs methylate histone arginines R-HSA-3214858 2.821134e-02 1.550 0 0
NrCAM interactions R-HSA-447038 2.954459e-02 1.530 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.821134e-02 1.550 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.847777e-02 1.545 0 0
FLT3 Signaling R-HSA-9607240 3.066523e-02 1.513 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 3.070800e-02 1.513 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 3.094915e-02 1.509 0 0
G alpha (12/13) signalling events R-HSA-416482 3.094915e-02 1.509 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.245261e-02 1.489 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.293953e-02 1.482 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.335753e-02 1.477 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 3.570935e-02 1.447 0 0
Muscle contraction R-HSA-397014 3.570935e-02 1.447 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 3.605978e-02 1.443 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.684618e-02 1.434 0 0
Formation of annular gap junctions R-HSA-196025 3.684618e-02 1.434 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.718509e-02 1.430 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.718509e-02 1.430 0 0
Adherens junctions interactions R-HSA-418990 3.718972e-02 1.430 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 4.346866e-02 1.362 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 4.346866e-02 1.362 0 0
Diseases of Telomere Maintenance R-HSA-9673013 4.346866e-02 1.362 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 4.346866e-02 1.362 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 4.346866e-02 1.362 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 4.346866e-02 1.362 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 4.346866e-02 1.362 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 4.346866e-02 1.362 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 4.346866e-02 1.362 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 4.346866e-02 1.362 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 3.957213e-02 1.403 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 3.987695e-02 1.399 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 3.987695e-02 1.399 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.987695e-02 1.399 0 0
Chaperone Mediated Autophagy R-HSA-9613829 3.887910e-02 1.410 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.193312e-02 1.377 0 0
Mitophagy R-HSA-5205647 4.204011e-02 1.376 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 4.204011e-02 1.376 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 4.204011e-02 1.376 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 4.065898e-02 1.391 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 4.229883e-02 1.374 0 0
Ephrin signaling R-HSA-3928664 3.887910e-02 1.410 0 0
Platelet sensitization by LDL R-HSA-432142 3.887910e-02 1.410 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 4.223296e-02 1.374 0 0
TRP channels R-HSA-3295583 4.193312e-02 1.377 0 0
Signaling by AMER1 mutants R-HSA-4839748 3.957213e-02 1.403 0 0
Neurexins and neuroligins R-HSA-6794361 4.358760e-02 1.361 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 4.446691e-02 1.352 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 4.446691e-02 1.352 0 0
Regulation of CDH1 Function R-HSA-9764561 4.457905e-02 1.351 0 0
Signaling by KIT in disease R-HSA-9669938 4.488140e-02 1.348 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 4.488140e-02 1.348 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 4.570654e-02 1.340 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 4.618589e-02 1.335 0 0
Vesicle-mediated transport R-HSA-5653656 4.667506e-02 1.331 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.763224e-02 1.322 0 0
Deubiquitination R-HSA-5688426 4.843573e-02 1.315 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 4.867812e-02 1.313 1 1
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.957316e-02 1.305 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 4.987581e-02 1.302 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 4.987581e-02 1.302 0 0
GP1b-IX-V activation signalling R-HSA-430116 5.001358e-02 1.301 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 5.001358e-02 1.301 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 5.001358e-02 1.301 0 0
Gap junction degradation R-HSA-190873 5.001358e-02 1.301 0 0
ALK mutants bind TKIs R-HSA-9700645 5.001358e-02 1.301 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 5.050316e-02 1.297 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 5.050316e-02 1.297 0 0
Signaling by PTK6 R-HSA-8848021 5.052414e-02 1.297 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.052414e-02 1.297 0 0
IRE1alpha activates chaperones R-HSA-381070 5.055725e-02 1.296 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 5.063111e-02 1.296 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 5.104011e-02 1.292 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.104011e-02 1.292 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 5.104011e-02 1.292 0 0
Signaling by LTK R-HSA-9842663 5.104011e-02 1.292 0 0
Estrogen-dependent gene expression R-HSA-9018519 5.183439e-02 1.285 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 6.289577e-02 1.201 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 5.809070e-02 1.236 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 6.149457e-02 1.211 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 6.149457e-02 1.211 0 0
Signaling by NOTCH4 R-HSA-9013694 5.635971e-02 1.249 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 5.410054e-02 1.267 0 0
Meiosis R-HSA-1500620 6.125139e-02 1.213 0 0
Diseases of mitotic cell cycle R-HSA-9675126 5.320944e-02 1.274 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 6.133054e-02 1.212 0 0
Signaling by NOTCH3 R-HSA-9012852 6.152607e-02 1.211 0 0
HIV Infection R-HSA-162906 6.200232e-02 1.208 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 6.149457e-02 1.211 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 6.216953e-02 1.206 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 6.133054e-02 1.212 0 0
Sensory processing of sound R-HSA-9659379 5.623412e-02 1.250 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 6.434292e-02 1.191 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 6.560941e-02 1.183 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 6.560941e-02 1.183 0 0
Negative regulation of MAPK pathway R-HSA-5675221 6.586301e-02 1.181 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.751061e-02 1.171 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 6.751061e-02 1.171 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 6.765187e-02 1.170 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 6.840514e-02 1.165 0 0
AURKA Activation by TPX2 R-HSA-8854518 6.863955e-02 1.163 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 7.058189e-02 1.151 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 7.058189e-02 1.151 0 0
Defective Base Excision Repair Associated with OGG1 R-HSA-9656249 8.800375e-02 1.055 0 0
Transport of glycerol from adipocytes to the liver by Aquaporins R-HSA-432030 8.800375e-02 1.055 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 8.800375e-02 1.055 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 8.800375e-02 1.055 0 0
Manipulation of host energy metabolism R-HSA-9636667 8.800375e-02 1.055 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 8.800375e-02 1.055 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 8.800375e-02 1.055 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 8.800375e-02 1.055 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 8.800375e-02 1.055 0 0
IKBKB deficiency causes SCID R-HSA-5602636 8.800375e-02 1.055 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 7.762499e-02 1.110 0 0
Regulation of gap junction activity R-HSA-191650 7.762499e-02 1.110 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 7.762499e-02 1.110 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 7.762499e-02 1.110 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 7.762499e-02 1.110 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 7.762499e-02 1.110 0 0
Signaling by MAP2K mutants R-HSA-9652169 7.762499e-02 1.110 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 7.762499e-02 1.110 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 8.472640e-02 1.072 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 8.472640e-02 1.072 0 0
Ionotropic activity of kainate receptors R-HSA-451306 8.361420e-02 1.078 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 7.949319e-02 1.100 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 8.868847e-02 1.052 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 8.114992e-02 1.091 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 7.784995e-02 1.109 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 7.784995e-02 1.109 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 7.784995e-02 1.109 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 8.911762e-02 1.050 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 8.911762e-02 1.050 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 8.224963e-02 1.085 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 8.391873e-02 1.076 0 0
Meiotic synapsis R-HSA-1221632 8.408481e-02 1.075 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 8.408481e-02 1.075 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 8.351565e-02 1.078 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 8.351565e-02 1.078 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 8.289877e-02 1.081 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 8.211891e-02 1.086 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 8.211891e-02 1.086 0 0
HCMV Early Events R-HSA-9609690 8.614016e-02 1.065 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 7.585804e-02 1.120 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 8.711118e-02 1.060 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 7.406594e-02 1.130 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 7.406594e-02 1.130 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 8.589948e-02 1.066 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.531002e-02 1.069 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 7.277063e-02 1.138 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 8.048534e-02 1.094 0 0
Trafficking of AMPA receptors R-HSA-399719 8.911762e-02 1.050 0 0
Interleukin-2 signaling R-HSA-9020558 8.361420e-02 1.078 0 0
Nuclear import of Rev protein R-HSA-180746 8.048534e-02 1.094 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 8.224963e-02 1.085 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 8.211891e-02 1.086 0 0
Apoptotic factor-mediated response R-HSA-111471 8.868847e-02 1.052 0 0
Breakdown of the nuclear lamina R-HSA-352238 8.800375e-02 1.055 0 0
Diseases of programmed cell death R-HSA-9645723 8.575311e-02 1.067 0 0
Metabolism of RNA R-HSA-8953854 7.342054e-02 1.134 0 0
Ca-dependent events R-HSA-111996 7.427159e-02 1.129 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 8.114992e-02 1.091 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.426703e-02 1.129 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 7.762499e-02 1.110 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 8.224963e-02 1.085 0 0
Signal regulatory protein family interactions R-HSA-391160 7.949319e-02 1.100 0 0
Interleukin-37 signaling R-HSA-9008059 7.784995e-02 1.109 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 9.121250e-02 1.040 0 0
snRNP Assembly R-HSA-191859 9.243074e-02 1.034 0 0
Metabolism of non-coding RNA R-HSA-194441 9.243074e-02 1.034 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 9.246831e-02 1.034 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 9.246831e-02 1.034 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 9.246831e-02 1.034 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 9.310748e-02 1.031 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 9.646793e-02 1.016 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 9.646793e-02 1.016 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 9.646793e-02 1.016 0 0
Centrosome maturation R-HSA-380287 9.752841e-02 1.011 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 9.879525e-02 1.005 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 9.879525e-02 1.005 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 9.896766e-02 1.005 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.013142e-01 0.994 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.014583e-01 0.994 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.014583e-01 0.994 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.014583e-01 0.994 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.014583e-01 0.994 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.014583e-01 0.994 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.022359e-01 0.990 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.027646e-01 0.988 0 0
Calmodulin induced events R-HSA-111933 1.027646e-01 0.988 0 0
CaM pathway R-HSA-111997 1.027646e-01 0.988 0 0
RUNX2 regulates bone development R-HSA-8941326 1.027646e-01 0.988 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.030222e-01 0.987 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.034284e-01 0.985 0 0
Activation of RAC1 R-HSA-428540 1.039483e-01 0.983 0 0
Integration of provirus R-HSA-162592 1.039483e-01 0.983 0 0
Regulation of signaling by CBL R-HSA-912631 1.045758e-01 0.981 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.045758e-01 0.981 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.045758e-01 0.981 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.047591e-01 0.980 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.051839e-01 0.978 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 1.097713e-01 0.960 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 1.097713e-01 0.960 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 1.097713e-01 0.960 0 0
IRS activation R-HSA-74713 1.097713e-01 0.960 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.097713e-01 0.960 0 0
Type I hemidesmosome assembly R-HSA-446107 1.097386e-01 0.960 0 0
MAPK1 (ERK2) activation R-HSA-112411 1.376246e-01 0.861 0 0
Pervasive developmental disorders R-HSA-9005895 1.264798e-01 0.898 0 0
Disorders of Nervous System Development R-HSA-9697154 1.264798e-01 0.898 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.264798e-01 0.898 0 0
Regulation of IFNG signaling R-HSA-877312 1.264798e-01 0.898 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.264798e-01 0.898 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.152108e-01 0.939 0 0
Disorders of Developmental Biology R-HSA-9675151 1.356355e-01 0.868 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 1.356355e-01 0.868 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 1.356355e-01 0.868 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 1.356355e-01 0.868 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.356355e-01 0.868 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.356355e-01 0.868 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.218887e-01 0.914 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.218887e-01 0.914 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.218887e-01 0.914 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.218887e-01 0.914 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.218887e-01 0.914 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.144319e-01 0.941 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.144319e-01 0.941 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.248073e-01 0.904 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.341782e-01 0.872 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.168688e-01 0.932 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.124125e-01 0.949 0 0
Neutrophil degranulation R-HSA-6798695 1.057720e-01 0.976 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.168688e-01 0.932 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.144319e-01 0.941 0 0
ESR-mediated signaling R-HSA-8939211 1.302850e-01 0.885 0 0
Signaling by NOTCH1 R-HSA-1980143 1.058778e-01 0.975 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.365510e-01 0.865 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.230342e-01 0.910 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.097386e-01 0.960 0 0
Meiotic recombination R-HSA-912446 1.136660e-01 0.944 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.151361e-01 0.939 0 0
RNA Polymerase I Transcription R-HSA-73864 1.238690e-01 0.907 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 1.097386e-01 0.960 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.300024e-01 0.886 0 0
Death Receptor Signaling R-HSA-73887 1.205608e-01 0.919 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.058778e-01 0.975 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.400686e-01 0.854 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 1.275536e-01 0.894 0 0
MTOR signalling R-HSA-165159 1.275536e-01 0.894 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.277196e-01 0.894 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 1.376246e-01 0.861 0 0
Signal transduction by L1 R-HSA-445144 1.218887e-01 0.914 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.257296e-01 0.901 0 0
Co-inhibition by BTLA R-HSA-9927353 1.097713e-01 0.960 0 0
Intraflagellar transport R-HSA-5620924 1.387494e-01 0.858 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 1.341782e-01 0.872 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.124484e-01 0.949 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.226724e-01 0.911 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.210895e-01 0.917 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.275536e-01 0.894 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 1.146583e-01 0.941 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.144319e-01 0.941 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.284549e-01 0.891 0 0
Stimuli-sensing channels R-HSA-2672351 1.402725e-01 0.853 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.144319e-01 0.941 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.283154e-01 0.892 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.235282e-01 0.908 0 0
Signaling by FGFR4 R-HSA-5654743 1.406963e-01 0.852 0 0
HIV Life Cycle R-HSA-162587 1.409324e-01 0.851 0 0
mRNA Editing: A to I Conversion R-HSA-75064 1.409967e-01 0.851 0 0
Regulation of TP53 Expression R-HSA-6804754 1.409967e-01 0.851 0 0
C6 deamination of adenosine R-HSA-75102 1.409967e-01 0.851 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.409967e-01 0.851 0 0
Tight junction interactions R-HSA-420029 1.429468e-01 0.845 0 0
TGFBR3 expression R-HSA-9839394 1.429468e-01 0.845 0 0
Ub-specific processing proteases R-HSA-5689880 1.432781e-01 0.844 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 1.433592e-01 0.844 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.433592e-01 0.844 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.435676e-01 0.843 0 0
DAP12 signaling R-HSA-2424491 1.436948e-01 0.843 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.436948e-01 0.843 0 0
Cilium Assembly R-HSA-5617833 1.450162e-01 0.839 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.460935e-01 0.835 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.460935e-01 0.835 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 1.460935e-01 0.835 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 1.460935e-01 0.835 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 1.460935e-01 0.835 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 1.460935e-01 0.835 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.460935e-01 0.835 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.462286e-01 0.835 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.479818e-01 0.830 0 0
Homology Directed Repair R-HSA-5693538 1.495586e-01 0.825 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.510334e-01 0.821 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.510334e-01 0.821 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 1.510334e-01 0.821 0 0
Interleukin-6 signaling R-HSA-1059683 1.510334e-01 0.821 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.514788e-01 0.820 0 0
KIT mutants bind TKIs R-HSA-9669921 1.514788e-01 0.820 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.514788e-01 0.820 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.514788e-01 0.820 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.514788e-01 0.820 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.514788e-01 0.820 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.514788e-01 0.820 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.514788e-01 0.820 0 0
Defective OGG1 Substrate Binding R-HSA-9656255 1.514788e-01 0.820 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.514788e-01 0.820 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.514788e-01 0.820 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.514788e-01 0.820 0 0
Defective OGG1 Localization R-HSA-9657050 1.514788e-01 0.820 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.514788e-01 0.820 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.514788e-01 0.820 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.514788e-01 0.820 0 0
Deletions in the AXIN1 gene destabilize the destruction complex R-HSA-5467345 1.514788e-01 0.820 0 0
Host Interactions of HIV factors R-HSA-162909 1.538743e-01 0.813 0 0
Cyclin D associated events in G1 R-HSA-69231 1.545357e-01 0.811 0 0
G1 Phase R-HSA-69236 1.545357e-01 0.811 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 1.566087e-01 0.805 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 1.570186e-01 0.804 0 0
Hedgehog 'off' state R-HSA-5610787 1.574780e-01 0.803 0 0
Glycolysis R-HSA-70171 1.574780e-01 0.803 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.576293e-01 0.802 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 1.576293e-01 0.802 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.581025e-01 0.801 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.581025e-01 0.801 0 0
UCH proteinases R-HSA-5689603 1.581058e-01 0.801 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.581149e-01 0.801 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.581149e-01 0.801 0 0
Generic Transcription Pathway R-HSA-212436 1.608498e-01 0.794 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.610627e-01 0.793 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 1.612603e-01 0.792 0 0
Myogenesis R-HSA-525793 1.612603e-01 0.792 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.612603e-01 0.792 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.622653e-01 0.790 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 1.680152e-01 0.775 0 0
2-LTR circle formation R-HSA-164843 1.680152e-01 0.775 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.680152e-01 0.775 0 0
Regulation of CDH11 function R-HSA-9762292 1.680152e-01 0.775 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.680152e-01 0.775 0 0
Signaling by Leptin R-HSA-2586552 1.680152e-01 0.775 0 0
Signaling by FGFR3 R-HSA-5654741 1.690483e-01 0.772 0 0
DAG and IP3 signaling R-HSA-1489509 1.690483e-01 0.772 0 0
PLC beta mediated events R-HSA-112043 1.708564e-01 0.767 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.988651e-01 0.701 0 0
Axonal growth stimulation R-HSA-209563 1.988651e-01 0.701 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 1.988651e-01 0.701 0 0
MET activates PTPN11 R-HSA-8865999 1.988651e-01 0.701 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 1.856887e-01 0.731 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.856887e-01 0.731 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 1.856887e-01 0.731 0 0
CHL1 interactions R-HSA-447041 2.276650e-01 0.643 0 0
Netrin mediated repulsion signals R-HSA-418886 2.276650e-01 0.643 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.276650e-01 0.643 0 0
TRIF-mediated programmed cell death R-HSA-2562578 2.276650e-01 0.643 0 0
PTK6 Expression R-HSA-8849473 2.276650e-01 0.643 0 0
IFNG signaling activates MAPKs R-HSA-9732724 2.276650e-01 0.643 0 0
SOS-mediated signalling R-HSA-112412 2.276650e-01 0.643 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 2.276650e-01 0.643 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 2.005039e-01 0.698 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.773997e-01 0.751 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.773997e-01 0.751 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 2.346670e-01 0.630 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.346670e-01 0.630 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.053447e-01 0.688 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.053447e-01 0.688 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.810578e-01 0.742 0 0
GAB1 signalosome R-HSA-180292 1.810578e-01 0.742 0 0
Germ layer formation at gastrulation R-HSA-9754189 2.057689e-01 0.687 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.346180e-01 0.630 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 1.806030e-01 0.743 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.806030e-01 0.743 0 0
G0 and Early G1 R-HSA-1538133 1.784649e-01 0.748 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 2.008974e-01 0.697 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 1.756790e-01 0.755 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.756790e-01 0.755 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.583702e-01 0.588 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 2.220578e-01 0.654 0 0
Late endosomal microautophagy R-HSA-9615710 2.220578e-01 0.654 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.512451e-01 0.600 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 2.110589e-01 0.676 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.297666e-01 0.639 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 2.490741e-01 0.604 0 0
Regulated Necrosis R-HSA-5218859 1.921467e-01 0.716 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.187947e-01 0.660 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.342554e-01 0.630 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 2.368282e-01 0.626 0 0
Co-inhibition by PD-1 R-HSA-389948 1.755093e-01 0.756 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.231917e-01 0.651 0 0
DNA Double Strand Break Response R-HSA-5693606 2.572132e-01 0.590 0 0
Signaling by NOTCH2 R-HSA-1980145 2.368009e-01 0.626 0 0
Signaling by EGFR R-HSA-177929 1.752658e-01 0.756 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.810578e-01 0.742 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 2.346670e-01 0.630 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.490741e-01 0.604 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.806030e-01 0.743 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.752658e-01 0.756 0 0
Synaptic adhesion-like molecules R-HSA-8849932 1.810578e-01 0.742 0 0
Platelet calcium homeostasis R-HSA-418360 2.220578e-01 0.654 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.973776e-01 0.705 0 0
Parasite infection R-HSA-9664407 1.741745e-01 0.759 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 1.741745e-01 0.759 0 0
Leishmania phagocytosis R-HSA-9664417 1.741745e-01 0.759 0 0
Interleukin-2 family signaling R-HSA-451927 2.490741e-01 0.604 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 2.110589e-01 0.676 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 2.276650e-01 0.643 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.187947e-01 0.660 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.791021e-01 0.747 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.971511e-01 0.705 0 0
RNA Polymerase II Transcription R-HSA-73857 2.090047e-01 0.680 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.936410e-01 0.713 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.936410e-01 0.713 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.936410e-01 0.713 0 0
G-protein mediated events R-HSA-112040 2.572132e-01 0.590 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.485284e-01 0.605 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.810578e-01 0.742 0 0
Ion homeostasis R-HSA-5578775 1.752658e-01 0.756 0 0
Signaling by TGFBR3 R-HSA-9839373 1.842060e-01 0.735 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.010425e-01 0.697 0 0
Circadian clock R-HSA-9909396 2.516064e-01 0.599 0 0
Formation of paraxial mesoderm R-HSA-9793380 2.501408e-01 0.602 0 0
Signaling by WNT in cancer R-HSA-4791275 1.784649e-01 0.748 0 0
Depurination R-HSA-73927 2.110589e-01 0.676 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.485284e-01 0.605 0 0
DNA Repair R-HSA-73894 2.155283e-01 0.666 0 0
Defective pyroptosis R-HSA-9710421 2.229343e-01 0.652 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 2.490741e-01 0.604 0 0
Diseases of Immune System R-HSA-5260271 2.490741e-01 0.604 0 0
Signalling to ERKs R-HSA-187687 2.576173e-01 0.589 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.211354e-01 0.655 0 0
Toll-like Receptor Cascades R-HSA-168898 1.932554e-01 0.714 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.005039e-01 0.698 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.053447e-01 0.688 0 0
Signaling by Hedgehog R-HSA-5358351 2.070464e-01 0.684 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.271720e-01 0.644 0 0
Neurodegenerative Diseases R-HSA-8863678 2.271720e-01 0.644 0 0
Hemostasis R-HSA-109582 2.027504e-01 0.693 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.971511e-01 0.705 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.576173e-01 0.589 0 0
Activation of BH3-only proteins R-HSA-114452 2.439916e-01 0.613 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.039477e-01 0.690 0 0
Basigin interactions R-HSA-210991 2.583702e-01 0.588 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.930111e-01 0.714 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 1.996045e-01 0.700 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 2.053447e-01 0.688 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.127046e-01 0.672 0 0
Ion channel transport R-HSA-983712 2.238862e-01 0.650 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 2.583702e-01 0.588 0 0
Growth hormone receptor signaling R-HSA-982772 2.039477e-01 0.690 0 0
Signaling by ALK R-HSA-201556 2.297666e-01 0.639 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.490741e-01 0.604 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 2.589173e-01 0.587 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 2.589173e-01 0.587 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.589173e-01 0.587 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.589173e-01 0.587 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.589173e-01 0.587 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 2.589173e-01 0.587 0 0
Dopamine receptors R-HSA-390651 2.589173e-01 0.587 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 2.589173e-01 0.587 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 2.589173e-01 0.587 0 0
Signaling by FGFR1 R-HSA-5654736 2.590030e-01 0.587 0 0
Defective OGG1 Substrate Processing R-HSA-9656256 2.800191e-01 0.553 0 0
TGFBR2 MSI Frameshift Mutants in Cancer R-HSA-3642279 2.800191e-01 0.553 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 2.800191e-01 0.553 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.800191e-01 0.553 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.800191e-01 0.553 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 2.800191e-01 0.553 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.800191e-01 0.553 0 0
Defective F8 binding to von Willebrand factor R-HSA-9672393 2.800191e-01 0.553 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.800191e-01 0.553 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.800191e-01 0.553 0 0
SARS-CoV-1 targets PDZ proteins in cell-cell junction R-HSA-9692912 2.800191e-01 0.553 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.800191e-01 0.553 0 0
Nef mediated downregulation of CD28 cell surface expression R-HSA-164939 3.890934e-01 0.410 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 3.890934e-01 0.410 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 3.890934e-01 0.410 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 3.890934e-01 0.410 0 0
Defective SLC12A3 causes Gitelman syndrome (GS) R-HSA-5619087 3.890934e-01 0.410 0 0
XAV939 stabilizes AXIN R-HSA-5545619 3.890934e-01 0.410 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.890934e-01 0.410 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 3.890934e-01 0.410 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 3.890934e-01 0.410 0 0
Defective VWF binding to collagen type I R-HSA-9845622 3.890934e-01 0.410 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.890934e-01 0.410 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 3.890934e-01 0.410 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.890934e-01 0.410 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 3.890934e-01 0.410 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 3.890934e-01 0.410 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 3.890934e-01 0.410 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.890934e-01 0.410 0 0
MPS IIID - Sanfilippo syndrome D R-HSA-2206305 3.890934e-01 0.410 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.890934e-01 0.410 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 3.890934e-01 0.410 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 3.890934e-01 0.410 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.890934e-01 0.410 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.890934e-01 0.410 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 3.191648e-01 0.496 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 3.191648e-01 0.496 0 0
Activation of AKT2 R-HSA-165158 3.191648e-01 0.496 0 0
Suppression of autophagy R-HSA-9636569 3.191648e-01 0.496 0 0
G2 Phase R-HSA-68911 3.191648e-01 0.496 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 3.191648e-01 0.496 0 0
NTRK2 activates RAC1 R-HSA-9032759 3.191648e-01 0.496 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 3.191648e-01 0.496 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 3.191648e-01 0.496 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 3.191648e-01 0.496 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.711845e-01 0.567 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 2.711845e-01 0.567 0 0
FGFR1b ligand binding and activation R-HSA-190370 2.711845e-01 0.567 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 2.711845e-01 0.567 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.700806e-01 0.569 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 2.700806e-01 0.569 0 0
IRAK1 recruits IKK complex R-HSA-937039 2.700806e-01 0.569 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 2.700806e-01 0.569 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.154883e-01 0.501 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 3.154883e-01 0.501 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.154883e-01 0.501 0 0
WNT mediated activation of DVL R-HSA-201688 3.154883e-01 0.501 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 3.781708e-01 0.422 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 3.781708e-01 0.422 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 3.781708e-01 0.422 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 3.781708e-01 0.422 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 3.781708e-01 0.422 0 0
PDE3B signalling R-HSA-165160 3.781708e-01 0.422 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 3.781708e-01 0.422 0 0
PKB-mediated events R-HSA-109703 3.781708e-01 0.422 0 0
Phosphorylation of Emi1 R-HSA-176417 3.781708e-01 0.422 0 0
Signaling by MAPK mutants R-HSA-9652817 3.781708e-01 0.422 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.816487e-01 0.317 0 0
Defective UGT1A4 causes hyperbilirubinemia R-HSA-5579016 4.816487e-01 0.317 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 4.816487e-01 0.317 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 4.816487e-01 0.317 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 4.816487e-01 0.317 0 0
Potassium transport channels R-HSA-1296067 4.816487e-01 0.317 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 4.816487e-01 0.317 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 4.816487e-01 0.317 0 0
Defective F8 cleavage by thrombin R-HSA-9672391 4.816487e-01 0.317 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 4.816487e-01 0.317 0 0
Defective SLC12A1 causes Bartter syndrome 1 (BS1) R-HSA-5619104 4.816487e-01 0.317 0 0
Defective visual phototransduction due to STRA6 loss of function R-HSA-9918449 4.816487e-01 0.317 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 2.649615e-01 0.577 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 3.063337e-01 0.514 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 3.063337e-01 0.514 0 0
Regulation of the apoptosome activity R-HSA-9627069 3.599105e-01 0.444 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 3.599105e-01 0.444 0 0
MAPK3 (ERK1) activation R-HSA-110056 3.599105e-01 0.444 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.961159e-01 0.529 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.961159e-01 0.529 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.961159e-01 0.529 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 2.961159e-01 0.529 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 4.349293e-01 0.362 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 4.349293e-01 0.362 1 1
STAT5 Activation R-HSA-9645135 4.349293e-01 0.362 0 0
Erythropoietin activates STAT5 R-HSA-9027283 4.349293e-01 0.362 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 4.349293e-01 0.362 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 4.349293e-01 0.362 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 3.140324e-01 0.503 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.140324e-01 0.503 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 4.038821e-01 0.394 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 4.038821e-01 0.394 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 4.038821e-01 0.394 0 0
Packaging Of Telomere Ends R-HSA-171306 3.014154e-01 0.521 0 0
Erythropoietin activates RAS R-HSA-9027284 3.798373e-01 0.420 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 3.798373e-01 0.420 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 3.598489e-01 0.444 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 3.272464e-01 0.485 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 2.892303e-01 0.539 0 0
HIV Transcription Initiation R-HSA-167161 2.892303e-01 0.539 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 2.892303e-01 0.539 0 0
mRNA 3'-end processing R-HSA-72187 2.866521e-01 0.543 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 3.713352e-01 0.430 0 0
Deadenylation of mRNA R-HSA-429947 3.713352e-01 0.430 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 3.919522e-01 0.407 0 0
Phosphorylation of the APC/C R-HSA-176412 4.164077e-01 0.380 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 4.469307e-01 0.350 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.469307e-01 0.350 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 4.469307e-01 0.350 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 4.469307e-01 0.350 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 4.887673e-01 0.311 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 4.887673e-01 0.311 0 0
Disinhibition of SNARE formation R-HSA-114516 4.887673e-01 0.311 0 0
Recycling of eIF2:GDP R-HSA-72731 4.887673e-01 0.311 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 3.309890e-01 0.480 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 3.617372e-01 0.442 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.891208e-01 0.539 0 0
Activation of the pre-replicative complex R-HSA-68962 3.797398e-01 0.421 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 4.239224e-01 0.373 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 4.239224e-01 0.373 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 4.239224e-01 0.373 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 4.239224e-01 0.373 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.683749e-01 0.434 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 4.524646e-01 0.344 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 4.524646e-01 0.344 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 3.737919e-01 0.427 0 0
RET signaling R-HSA-8853659 4.106804e-01 0.386 0 0
Regulation of endogenous retroelements R-HSA-9842860 3.148836e-01 0.502 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 3.954105e-01 0.403 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 4.555643e-01 0.341 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 4.555643e-01 0.341 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 4.555643e-01 0.341 0 0
Signaling by ERBB4 R-HSA-1236394 3.733239e-01 0.428 0 0
Signaling by FGFR2 R-HSA-5654738 3.760621e-01 0.425 0 0
IGF1R signaling cascade R-HSA-2428924 4.041405e-01 0.393 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.194121e-01 0.377 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.928078e-01 0.406 0 0
Translation initiation complex formation R-HSA-72649 4.399889e-01 0.357 0 0
Pyroptosis R-HSA-5620971 4.856409e-01 0.314 0 0
Regulation of RAS by GAPs R-HSA-5658442 4.817784e-01 0.317 0 0
Interleukin receptor SHC signaling R-HSA-912526 5.171845e-01 0.286 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 5.133347e-01 0.290 0 0
DNA methylation R-HSA-5334118 5.133347e-01 0.290 0 0
Dual Incision in GG-NER R-HSA-5696400 5.101665e-01 0.292 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 5.074713e-01 0.295 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 5.074713e-01 0.295 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 5.074713e-01 0.295 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 5.162935e-01 0.287 0 0
Insulin receptor signalling cascade R-HSA-74751 5.186227e-01 0.285 0 0
Signaling by EGFR in Cancer R-HSA-1643713 4.289364e-01 0.368 0 0
Transcription of the HIV genome R-HSA-167172 3.702236e-01 0.432 0 0
Interferon gamma signaling R-HSA-877300 3.842840e-01 0.415 0 0
EGFR downregulation R-HSA-182971 4.061479e-01 0.391 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 4.433598e-01 0.353 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 4.867031e-01 0.313 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.897839e-01 0.538 0 0
Chromosome Maintenance R-HSA-73886 3.007594e-01 0.522 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.594753e-01 0.586 0 0
Formation of apoptosome R-HSA-111458 3.599105e-01 0.444 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 2.961159e-01 0.529 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 4.038821e-01 0.394 0 0
Intra-Golgi traffic R-HSA-6811438 2.892303e-01 0.539 0 0
Signalling to RAS R-HSA-167044 4.239224e-01 0.373 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 4.229597e-01 0.374 0 0
mRNA Editing R-HSA-75072 3.154883e-01 0.501 0 0
Activation of SMO R-HSA-5635838 4.164077e-01 0.380 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.601899e-01 0.585 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.912752e-01 0.408 0 0
p75NTR signals via NF-kB R-HSA-193639 3.798373e-01 0.420 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 3.599105e-01 0.444 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 3.008359e-01 0.522 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.001772e-01 0.398 0 0
Epigenetic regulation of gene expression R-HSA-212165 4.827998e-01 0.316 0 0
Interleukin-15 signaling R-HSA-8983432 4.886750e-01 0.311 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.733239e-01 0.428 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 3.781708e-01 0.422 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 4.887673e-01 0.311 0 0
MET activates RAS signaling R-HSA-8851805 4.886750e-01 0.311 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 4.867031e-01 0.313 0 0
PCP/CE pathway R-HSA-4086400 4.429445e-01 0.354 0 0
G1/S Transition R-HSA-69206 4.444928e-01 0.352 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 3.374562e-01 0.472 0 0
Killing mechanisms R-HSA-9664420 4.164077e-01 0.380 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 4.164077e-01 0.380 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 4.886750e-01 0.311 0 0
Activation of ATR in response to replication stress R-HSA-176187 4.586924e-01 0.338 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.859083e-01 0.544 0 0
Resolution of D-Loop Structures R-HSA-5693537 3.374562e-01 0.472 0 0
Early Phase of HIV Life Cycle R-HSA-162594 4.239224e-01 0.373 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 2.762603e-01 0.559 0 0
Gene expression (Transcription) R-HSA-74160 2.829507e-01 0.548 0 0
Mismatch Repair R-HSA-5358508 3.278265e-01 0.484 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 2.762603e-01 0.559 0 0
NADPH regeneration R-HSA-389542 4.349293e-01 0.362 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 3.134371e-01 0.504 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 4.887673e-01 0.311 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 4.886750e-01 0.311 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 4.106804e-01 0.386 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 3.132713e-01 0.504 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 3.853681e-01 0.414 0 0
mTORC1-mediated signalling R-HSA-166208 4.867031e-01 0.313 0 0
G2/M Checkpoints R-HSA-69481 4.718214e-01 0.326 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.746061e-01 0.561 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 3.571735e-01 0.447 0 0
Activation of HOX genes during differentiation R-HSA-5619507 3.571735e-01 0.447 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 3.132713e-01 0.504 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.008359e-01 0.522 0 0
PTEN Regulation R-HSA-6807070 3.444767e-01 0.463 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 4.770158e-01 0.321 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.954105e-01 0.403 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 2.760371e-01 0.559 0 0
Signaling by TGFB family members R-HSA-9006936 2.656754e-01 0.576 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 4.151211e-01 0.382 0 0
TNF signaling R-HSA-75893 3.626147e-01 0.441 0 0
DNA Replication Pre-Initiation R-HSA-69002 3.453924e-01 0.462 0 0
Somitogenesis R-HSA-9824272 5.051216e-01 0.297 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 3.148723e-01 0.502 0 0
HCMV Infection R-HSA-9609646 3.099606e-01 0.509 0 0
Signaling by Nuclear Receptors R-HSA-9006931 4.120367e-01 0.385 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 3.191648e-01 0.496 0 0
Cleavage of the damaged purine R-HSA-110331 3.008359e-01 0.522 0 0
Effects of PIP2 hydrolysis R-HSA-114508 3.374562e-01 0.472 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 4.469307e-01 0.350 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 4.469307e-01 0.350 0 0
Ca2+ activated K+ channels R-HSA-1296052 4.887673e-01 0.311 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.789057e-01 0.555 0 0
NOD1/2 Signaling Pathway R-HSA-168638 3.617372e-01 0.442 0 0
G-protein beta:gamma signalling R-HSA-397795 4.586924e-01 0.338 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.048985e-01 0.516 0 0
Rab regulation of trafficking R-HSA-9007101 4.026400e-01 0.395 0 0
Signaling by WNT R-HSA-195721 3.176821e-01 0.498 0 0
Developmental Biology R-HSA-1266738 3.530048e-01 0.452 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 4.524646e-01 0.344 0 0
MAP kinase activation R-HSA-450294 3.481402e-01 0.458 0 0
S Phase R-HSA-69242 3.243792e-01 0.489 0 0
Frs2-mediated activation R-HSA-170968 3.063337e-01 0.514 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 3.430385e-01 0.465 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.134371e-01 0.504 0 0
Neuronal System R-HSA-112316 3.130313e-01 0.504 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.606909e-01 0.584 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 3.191648e-01 0.496 0 0
Neurofascin interactions R-HSA-447043 4.349293e-01 0.362 0 0
tRNA processing in the nucleus R-HSA-6784531 2.664173e-01 0.574 0 0
TBC/RABGAPs R-HSA-8854214 4.600091e-01 0.337 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 4.051339e-01 0.392 0 0
Interleukin-17 signaling R-HSA-448424 5.162935e-01 0.287 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 4.297503e-01 0.367 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 4.142325e-01 0.383 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.612621e-01 0.442 0 0
FLT3 signaling in disease R-HSA-9682385 4.106804e-01 0.386 0 0
Transmission across Chemical Synapses R-HSA-112315 3.780700e-01 0.422 0 0
Protein methylation R-HSA-8876725 3.798373e-01 0.420 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 4.887673e-01 0.311 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 4.877617e-01 0.312 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.653005e-01 0.576 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 4.777447e-01 0.321 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 4.524646e-01 0.344 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 4.016365e-01 0.396 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 4.854478e-01 0.314 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.140324e-01 0.503 0 0
Prolonged ERK activation events R-HSA-169893 4.164077e-01 0.380 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 4.863416e-01 0.313 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 2.897748e-01 0.538 0 0
DAP12 interactions R-HSA-2172127 4.826823e-01 0.316 0 0
Inhibition of PKR R-HSA-169131 2.800191e-01 0.553 0 0
Transport of connexins along the secretory pathway R-HSA-190827 3.890934e-01 0.410 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.890934e-01 0.410 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 3.191648e-01 0.496 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.781708e-01 0.422 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 4.816487e-01 0.317 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 3.063337e-01 0.514 0 0
The NLRP3 inflammasome R-HSA-844456 3.598489e-01 0.444 0 0
Negative regulation of FLT3 R-HSA-9706369 4.164077e-01 0.380 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 4.887673e-01 0.311 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 3.737919e-01 0.427 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 4.886750e-01 0.311 0 0
Mitochondrial calcium ion transport R-HSA-8949215 4.555643e-01 0.341 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 4.574683e-01 0.340 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.062346e-01 0.391 0 0
Degradation of CDH1 R-HSA-9766229 4.603289e-01 0.337 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 4.605770e-01 0.337 0 0
Signaling by NTRKs R-HSA-166520 3.243792e-01 0.489 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.706141e-01 0.568 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.859925e-01 0.413 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.041405e-01 0.393 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 4.586924e-01 0.338 0 0
Platelet degranulation R-HSA-114608 4.718214e-01 0.326 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.014154e-01 0.521 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 3.224326e-01 0.492 0 0
Smooth Muscle Contraction R-HSA-445355 3.052385e-01 0.515 0 0
Suppression of apoptosis R-HSA-9635465 4.038821e-01 0.394 0 0
Gene Silencing by RNA R-HSA-211000 4.005284e-01 0.397 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 4.602124e-01 0.337 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 4.555643e-01 0.341 0 0
Ion transport by P-type ATPases R-HSA-936837 4.041405e-01 0.393 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.784643e-01 0.555 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 4.887673e-01 0.311 0 0
Glucose metabolism R-HSA-70326 4.026400e-01 0.395 0 0
Reproduction R-HSA-1474165 4.444693e-01 0.352 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.700806e-01 0.569 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 4.856409e-01 0.314 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 4.877617e-01 0.312 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 3.497481e-01 0.456 0 0
Oligomerization of connexins into connexons R-HSA-190704 3.890934e-01 0.410 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.154883e-01 0.501 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 3.278265e-01 0.484 0 0
OAS antiviral response R-HSA-8983711 4.886750e-01 0.311 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 3.781708e-01 0.422 0 0
Diseases of Base Excision Repair R-HSA-9605308 3.781708e-01 0.422 0 0
Adrenoceptors R-HSA-390696 2.711845e-01 0.567 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 3.781708e-01 0.422 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 2.689174e-01 0.570 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 4.887673e-01 0.311 0 0
Uptake and function of anthrax toxins R-HSA-5210891 4.877617e-01 0.312 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 2.866521e-01 0.543 0 0
Other semaphorin interactions R-HSA-416700 3.798373e-01 0.420 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 3.617372e-01 0.442 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 4.038821e-01 0.394 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 3.617372e-01 0.442 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 5.206956e-01 0.283 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 5.211883e-01 0.283 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 5.220909e-01 0.282 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 5.220909e-01 0.282 0 0
Polo-like kinase mediated events R-HSA-156711 5.220909e-01 0.282 0 0
Tie2 Signaling R-HSA-210993 5.220909e-01 0.282 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 5.240443e-01 0.281 0 0
Assembly of the pre-replicative complex R-HSA-68867 5.246596e-01 0.280 0 0
Adenylate cyclase activating pathway R-HSA-170660 5.288176e-01 0.277 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 5.288176e-01 0.277 0 0
FGFR1c ligand binding and activation R-HSA-190373 5.288176e-01 0.277 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.288176e-01 0.277 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 5.288176e-01 0.277 0 0
Maturation of nucleoprotein R-HSA-9683610 5.288176e-01 0.277 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 5.309547e-01 0.275 0 0
TCR signaling R-HSA-202403 5.335653e-01 0.273 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 5.392669e-01 0.268 0 0
phospho-PLA2 pathway R-HSA-111995 5.392669e-01 0.268 0 0
MET receptor recycling R-HSA-8875656 5.392669e-01 0.268 0 0
Activation of RAS in B cells R-HSA-1169092 5.392669e-01 0.268 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 5.392669e-01 0.268 0 0
Interleukin-9 signaling R-HSA-8985947 5.392669e-01 0.268 0 0
Regulation by c-FLIP R-HSA-3371378 5.392669e-01 0.268 0 0
Dimerization of procaspase-8 R-HSA-69416 5.392669e-01 0.268 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 5.392669e-01 0.268 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 5.392669e-01 0.268 0 0
RSK activation R-HSA-444257 5.392669e-01 0.268 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 5.404432e-01 0.267 0 0
Regulation of beta-cell development R-HSA-186712 5.409691e-01 0.267 0 0
Regulation of PTEN stability and activity R-HSA-8948751 5.447569e-01 0.264 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 5.468757e-01 0.262 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 5.468757e-01 0.262 0 0
Interleukin-6 family signaling R-HSA-6783589 5.468757e-01 0.262 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 5.490548e-01 0.260 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 5.490548e-01 0.260 0 0
Signaling by ROBO receptors R-HSA-376176 5.534264e-01 0.257 0 0
Signaling by FGFR1 in disease R-HSA-5655302 5.540101e-01 0.256 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 5.552808e-01 0.255 0 0
Translesion Synthesis by POLH R-HSA-110320 5.552808e-01 0.255 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 5.552808e-01 0.255 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 5.552808e-01 0.255 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 5.552808e-01 0.255 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 5.552808e-01 0.255 0 0
Rap1 signalling R-HSA-392517 5.552808e-01 0.255 0 0
Other interleukin signaling R-HSA-449836 5.552808e-01 0.255 0 0
Maturation of nucleoprotein R-HSA-9694631 5.552808e-01 0.255 0 0
G1/S-Specific Transcription R-HSA-69205 5.598386e-01 0.252 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 5.601859e-01 0.252 0 0
Activation of Na-permeable kainate receptors R-HSA-451307 5.601859e-01 0.252 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 5.601859e-01 0.252 0 0
Defective ABCA1 causes TGD R-HSA-5682113 5.601859e-01 0.252 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 5.601859e-01 0.252 0 0
Defective HPRT1 disrupts guanine and hypoxanthine salvage R-HSA-9734281 5.601859e-01 0.252 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 5.601859e-01 0.252 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 5.601859e-01 0.252 0 0
Classical Kir channels R-HSA-1296053 5.601859e-01 0.252 0 0
Invadopodia formation R-HSA-8941237 5.601859e-01 0.252 0 0
MET interacts with TNS proteins R-HSA-8875513 5.601859e-01 0.252 0 0
Tachykinin receptors bind tachykinins R-HSA-380095 5.601859e-01 0.252 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 5.601859e-01 0.252 0 0
Histamine receptors R-HSA-390650 5.601859e-01 0.252 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 5.601859e-01 0.252 0 0
Inositol phosphate metabolism R-HSA-1483249 5.625291e-01 0.250 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 5.651263e-01 0.248 0 0
Budding and maturation of HIV virion R-HSA-162588 5.668737e-01 0.247 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.668737e-01 0.247 0 0
Downstream signal transduction R-HSA-186763 5.668737e-01 0.247 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 5.671363e-01 0.246 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.671363e-01 0.246 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 5.671363e-01 0.246 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 5.671363e-01 0.246 0 0
Malate-aspartate shuttle R-HSA-9856872 5.671363e-01 0.246 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 5.684596e-01 0.245 0 0
NGF-stimulated transcription R-HSA-9031628 5.704391e-01 0.244 0 0
Interleukin-7 signaling R-HSA-1266695 5.756639e-01 0.240 0 0
HDMs demethylate histones R-HSA-3214842 5.756639e-01 0.240 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 5.765776e-01 0.239 0 0
Depyrimidination R-HSA-73928 5.765776e-01 0.239 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 5.851104e-01 0.233 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 5.862040e-01 0.232 0 0
Regulated proteolysis of p75NTR R-HSA-193692 5.862040e-01 0.232 0 0
Interleukin-21 signaling R-HSA-9020958 5.862040e-01 0.232 0 0
Lipophagy R-HSA-9613354 5.862040e-01 0.232 0 0
CASP8 activity is inhibited R-HSA-5218900 5.862040e-01 0.232 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 5.862040e-01 0.232 0 0
p75NTR regulates axonogenesis R-HSA-193697 5.862040e-01 0.232 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 5.862040e-01 0.232 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 5.862040e-01 0.232 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 5.862040e-01 0.232 0 0
Calcineurin activates NFAT R-HSA-2025928 5.862040e-01 0.232 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 5.862040e-01 0.232 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 5.862040e-01 0.232 0 0
Interleukin-1 processing R-HSA-448706 5.862040e-01 0.232 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 5.862040e-01 0.232 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 5.862040e-01 0.232 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 5.862040e-01 0.232 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 5.870502e-01 0.231 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 5.871949e-01 0.231 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 5.871949e-01 0.231 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 5.871949e-01 0.231 0 0
Signaling by NODAL R-HSA-1181150 5.871949e-01 0.231 0 0
DNA Damage Bypass R-HSA-73893 5.913707e-01 0.228 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 5.913707e-01 0.228 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 5.913707e-01 0.228 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 5.919724e-01 0.228 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.983971e-01 0.223 0 0
Heme signaling R-HSA-9707616 5.983971e-01 0.223 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 5.986044e-01 0.223 0 0
Response of Mtb to phagocytosis R-HSA-9637690 5.986044e-01 0.223 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 5.992346e-01 0.222 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 6.034566e-01 0.219 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 6.034566e-01 0.219 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 6.034749e-01 0.219 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 6.034749e-01 0.219 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 6.034749e-01 0.219 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.034749e-01 0.219 0 0
p38MAPK events R-HSA-171007 6.034749e-01 0.219 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.034749e-01 0.219 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.034749e-01 0.219 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 6.034749e-01 0.219 0 0
Immune System R-HSA-168256 6.045542e-01 0.219 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 6.046712e-01 0.218 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 6.046712e-01 0.218 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 6.046712e-01 0.218 0 0
Adaptive Immune System R-HSA-1280218 6.116287e-01 0.214 0 0
PI3K Cascade R-HSA-109704 6.118077e-01 0.213 0 0
Opioid Signalling R-HSA-111885 6.126224e-01 0.213 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 6.168436e-01 0.210 0 0
Signaling by FGFR R-HSA-190236 6.169794e-01 0.210 0 0
Cardiogenesis R-HSA-9733709 6.173934e-01 0.209 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 6.173934e-01 0.209 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 6.177287e-01 0.209 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 6.177287e-01 0.209 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 6.177287e-01 0.209 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 6.177287e-01 0.209 0 0
Adipogenesis R-HSA-9843745 6.203040e-01 0.207 0 0
Cardiac conduction R-HSA-5576891 6.203040e-01 0.207 0 0
MTF1 activates gene expression R-HSA-5660489 6.268274e-01 0.203 0 0
HCN channels R-HSA-1296061 6.268274e-01 0.203 0 0
NADE modulates death signalling R-HSA-205025 6.268274e-01 0.203 0 0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine R-HSA-9735763 6.268274e-01 0.203 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 6.268274e-01 0.203 0 0
ATP sensitive Potassium channels R-HSA-1296025 6.268274e-01 0.203 0 0
Nucleotide catabolism defects R-HSA-9735786 6.268274e-01 0.203 0 0
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate R-HSA-2978092 6.268274e-01 0.203 0 0
TNFR1-mediated ceramide production R-HSA-5626978 6.268274e-01 0.203 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 6.268274e-01 0.203 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 6.268274e-01 0.203 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 6.268274e-01 0.203 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 6.268274e-01 0.203 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.279338e-01 0.202 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 6.294988e-01 0.201 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 6.294988e-01 0.201 0 0
PI3K/AKT activation R-HSA-198203 6.294988e-01 0.201 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 6.294988e-01 0.201 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 6.294988e-01 0.201 0 0
Interleukin-27 signaling R-HSA-9020956 6.294988e-01 0.201 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 6.294988e-01 0.201 0 0
Josephin domain DUBs R-HSA-5689877 6.294988e-01 0.201 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 6.294988e-01 0.201 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 6.297234e-01 0.201 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 6.297234e-01 0.201 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 6.297234e-01 0.201 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 6.301799e-01 0.201 0 0
Cristae formation R-HSA-8949613 6.301799e-01 0.201 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 6.301799e-01 0.201 0 0
Interferon alpha/beta signaling R-HSA-909733 6.319085e-01 0.199 0 0
Phase 4 - resting membrane potential R-HSA-5576886 6.377342e-01 0.195 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 6.377342e-01 0.195 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 6.377342e-01 0.195 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.377342e-01 0.195 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 6.377342e-01 0.195 0 0
Atorvastatin ADME R-HSA-9754706 6.377342e-01 0.195 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.377342e-01 0.195 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 6.377342e-01 0.195 0 0
Differentiation of T cells R-HSA-9945266 6.377342e-01 0.195 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 6.413609e-01 0.193 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 6.449058e-01 0.191 0 0
Regulation of mitotic cell cycle R-HSA-453276 6.449058e-01 0.191 0 0
Hedgehog 'on' state R-HSA-5632684 6.449058e-01 0.191 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 6.468071e-01 0.189 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.468071e-01 0.189 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 6.468071e-01 0.189 0 0
Assembly Of The HIV Virion R-HSA-175474 6.468071e-01 0.189 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 6.510558e-01 0.186 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 6.510558e-01 0.186 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.510558e-01 0.186 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 6.515734e-01 0.186 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 6.515734e-01 0.186 0 0
HIV Transcription Elongation R-HSA-167169 6.515734e-01 0.186 0 0
Generation of second messenger molecules R-HSA-202433 6.515734e-01 0.186 0 0
Platelet homeostasis R-HSA-418346 6.546584e-01 0.184 0 0
Formation of the Early Elongation Complex R-HSA-113418 6.557774e-01 0.183 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 6.557774e-01 0.183 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 6.557774e-01 0.183 0 0
Inflammasomes R-HSA-622312 6.557774e-01 0.183 0 0
Leishmania infection R-HSA-9658195 6.565532e-01 0.183 0 0
Parasitic Infection Pathways R-HSA-9824443 6.565532e-01 0.183 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 6.610111e-01 0.180 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 6.614576e-01 0.179 0 0
Developmental Cell Lineages R-HSA-9734767 6.635717e-01 0.178 0 0
Signal amplification R-HSA-392518 6.644055e-01 0.178 0 0
Interleukin-1 family signaling R-HSA-446652 6.686639e-01 0.175 0 0
FGFR2b ligand binding and activation R-HSA-190377 6.691773e-01 0.174 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 6.691773e-01 0.174 0 0
Dissolution of Fibrin Clot R-HSA-75205 6.691773e-01 0.174 0 0
Chylomicron assembly R-HSA-8963888 6.691773e-01 0.174 0 0
vRNP Assembly R-HSA-192905 6.691773e-01 0.174 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 6.691773e-01 0.174 0 0
Prostanoid ligand receptors R-HSA-391908 6.691773e-01 0.174 0 0
LGI-ADAM interactions R-HSA-5682910 6.691773e-01 0.174 0 0
ChREBP activates metabolic gene expression R-HSA-163765 6.691773e-01 0.174 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 6.698086e-01 0.174 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 6.698630e-01 0.174 0 0
Passive transport by Aquaporins R-HSA-432047 6.698630e-01 0.174 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 6.726376e-01 0.172 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 6.726376e-01 0.172 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 6.743809e-01 0.171 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 6.743809e-01 0.171 0 0
FGFR2 alternative splicing R-HSA-6803529 6.743809e-01 0.171 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 6.743809e-01 0.171 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 6.743809e-01 0.171 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 6.743809e-01 0.171 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 6.782041e-01 0.169 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.795373e-01 0.168 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 6.802092e-01 0.167 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 6.804780e-01 0.167 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 6.833745e-01 0.165 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 6.833745e-01 0.165 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.833745e-01 0.165 0 0
Defective F9 activation R-HSA-9673221 6.833745e-01 0.165 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 6.833745e-01 0.165 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 6.833745e-01 0.165 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 6.833745e-01 0.165 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 6.833745e-01 0.165 0 0
Reelin signalling pathway R-HSA-8866376 6.833745e-01 0.165 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 6.833745e-01 0.165 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 6.833745e-01 0.165 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 6.833745e-01 0.165 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 6.833745e-01 0.165 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 6.833745e-01 0.165 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 6.864950e-01 0.163 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 6.864950e-01 0.163 0 0
PERK regulates gene expression R-HSA-381042 6.864950e-01 0.163 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 6.950804e-01 0.158 0 0
Viral Messenger RNA Synthesis R-HSA-168325 6.950804e-01 0.158 0 0
GPER1 signaling R-HSA-9634597 6.992372e-01 0.155 0 0
Gluconeogenesis R-HSA-70263 6.992372e-01 0.155 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.998502e-01 0.155 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 6.998502e-01 0.155 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.998502e-01 0.155 0 0
Specification of primordial germ cells R-HSA-9827857 6.998502e-01 0.155 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.002496e-01 0.155 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 7.004242e-01 0.155 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.004242e-01 0.155 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.004242e-01 0.155 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 7.004242e-01 0.155 0 0
Syndecan interactions R-HSA-3000170 7.004242e-01 0.155 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 7.004242e-01 0.155 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 7.034497e-01 0.153 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 7.034497e-01 0.153 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 7.053414e-01 0.152 0 0
ERKs are inactivated R-HSA-202670 7.053414e-01 0.152 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 7.053414e-01 0.152 0 0
NF-kB is activated and signals survival R-HSA-209560 7.053414e-01 0.152 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 7.053414e-01 0.152 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 7.053414e-01 0.152 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 7.053414e-01 0.152 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 7.076075e-01 0.150 0 0
RNA Polymerase III Transcription R-HSA-74158 7.076075e-01 0.150 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 7.115297e-01 0.148 0 0
Mitochondrial protein import R-HSA-1268020 7.115297e-01 0.148 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 7.123126e-01 0.147 0 0
Thromboxane signalling through TP receptor R-HSA-428930 7.249308e-01 0.140 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 7.249308e-01 0.140 0 0
Nucleotide Excision Repair R-HSA-5696398 7.253759e-01 0.139 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 7.274010e-01 0.138 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 7.274010e-01 0.138 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 7.277171e-01 0.138 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 7.277171e-01 0.138 0 0
FGFR1 ligand binding and activation R-HSA-190242 7.277171e-01 0.138 0 0
PKA activation in glucagon signalling R-HSA-164378 7.277171e-01 0.138 0 0
PKA activation R-HSA-163615 7.277171e-01 0.138 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 7.277171e-01 0.138 0 0
Voltage gated Potassium channels R-HSA-1296072 7.277300e-01 0.138 0 0
Degradation of DVL R-HSA-4641258 7.277300e-01 0.138 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 7.277300e-01 0.138 0 0
TRAIL signaling R-HSA-75158 7.313558e-01 0.136 0 0
Plus-strand DNA synthesis R-HSA-164525 7.313558e-01 0.136 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 7.313558e-01 0.136 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 7.313558e-01 0.136 0 0
NGF-independant TRKA activation R-HSA-187024 7.313558e-01 0.136 0 0
Pentose phosphate pathway disease R-HSA-6791465 7.313558e-01 0.136 0 0
Proton/oligopeptide cotransporters R-HSA-427975 7.313558e-01 0.136 0 0
Formation of the Editosome R-HSA-75094 7.313558e-01 0.136 0 0
Ceramide signalling R-HSA-193681 7.313558e-01 0.136 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 7.313558e-01 0.136 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 7.313558e-01 0.136 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 7.313558e-01 0.136 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 7.313558e-01 0.136 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 7.313558e-01 0.136 0 0
Ligand-receptor interactions R-HSA-5632681 7.313558e-01 0.136 0 0
VEGF ligand-receptor interactions R-HSA-194313 7.313558e-01 0.136 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 7.324275e-01 0.135 0 0
Mitochondrial biogenesis R-HSA-1592230 7.365120e-01 0.133 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 7.381449e-01 0.132 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 7.381449e-01 0.132 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 7.381449e-01 0.132 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.381449e-01 0.132 0 0
Scavenging by Class F Receptors R-HSA-3000484 7.381449e-01 0.132 0 0
Interleukin-35 Signalling R-HSA-8984722 7.381449e-01 0.132 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 7.381449e-01 0.132 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 7.381449e-01 0.132 0 0
IRS-mediated signalling R-HSA-112399 7.385518e-01 0.132 0 0
Formation of the cornified envelope R-HSA-6809371 7.417859e-01 0.130 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 7.426330e-01 0.129 0 0
SARS-CoV-2 Infection R-HSA-9694516 7.429483e-01 0.129 0 0
MET promotes cell motility R-HSA-8875878 7.468583e-01 0.127 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 7.468583e-01 0.127 0 0
Base Excision Repair R-HSA-73884 7.470065e-01 0.127 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.479118e-01 0.126 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 7.479118e-01 0.126 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.479118e-01 0.126 0 0
Formation of the nephric duct R-HSA-9830364 7.479118e-01 0.126 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.511392e-01 0.124 0 0
Viral Infection Pathways R-HSA-9824446 7.515149e-01 0.124 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 7.535113e-01 0.123 0 0
Dual incision in TC-NER R-HSA-6782135 7.541156e-01 0.123 0 0
PI Metabolism R-HSA-1483255 7.562106e-01 0.121 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 7.606503e-01 0.119 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 7.631157e-01 0.117 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 7.631157e-01 0.117 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 7.631157e-01 0.117 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.643815e-01 0.117 0 0
Stabilization of p53 R-HSA-69541 7.649954e-01 0.116 0 0
Pentose phosphate pathway R-HSA-71336 7.649954e-01 0.116 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 7.655123e-01 0.116 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 7.655123e-01 0.116 0 0
Nuclear RNA decay R-HSA-9930044 7.659582e-01 0.116 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 7.669627e-01 0.115 0 0
FGFR2c ligand binding and activation R-HSA-190375 7.677757e-01 0.115 0 0
Formation of axial mesoderm R-HSA-9796292 7.677757e-01 0.115 0 0
Diseases of nucleotide metabolism R-HSA-9735804 7.677757e-01 0.115 0 0
FGFR4 ligand binding and activation R-HSA-190322 7.677757e-01 0.115 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 7.677757e-01 0.115 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 7.677757e-01 0.115 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 7.677757e-01 0.115 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 7.677757e-01 0.115 0 0
FGFR3 mutant receptor activation R-HSA-2033514 7.677757e-01 0.115 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 7.677757e-01 0.115 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.693924e-01 0.114 0 0
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) R-HSA-3656244 7.720683e-01 0.112 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 7.720683e-01 0.112 0 0
Uncoating of the HIV Virion R-HSA-162585 7.720683e-01 0.112 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 7.720683e-01 0.112 0 0
Defective ST3GAL3 causes MCT12 and EIEE15 R-HSA-3656243 7.720683e-01 0.112 0 0
Defective CHST6 causes MCDC1 R-HSA-3656225 7.720683e-01 0.112 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 7.720683e-01 0.112 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 7.720683e-01 0.112 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 7.720683e-01 0.112 0 0
G2/M DNA replication checkpoint R-HSA-69478 7.720683e-01 0.112 0 0
Abacavir transmembrane transport R-HSA-2161517 7.720683e-01 0.112 0 0
Defective factor VIII causes hemophilia A R-HSA-9662001 7.720683e-01 0.112 0 0
Metabolism of vitamin K R-HSA-6806664 7.720683e-01 0.112 0 0
Signaling by LTK in cancer R-HSA-9842640 7.720683e-01 0.112 0 0
VLDL assembly R-HSA-8866423 7.720683e-01 0.112 0 0
Signaling by MET R-HSA-6806834 7.771419e-01 0.109 0 0
Formation of definitive endoderm R-HSA-9823730 7.773001e-01 0.109 0 0
Nephrin family interactions R-HSA-373753 7.773001e-01 0.109 0 0
Negative regulation of MET activity R-HSA-6807004 7.773001e-01 0.109 0 0
Protein hydroxylation R-HSA-9629569 7.773001e-01 0.109 0 0
SARS-CoV-1 Infection R-HSA-9678108 7.784116e-01 0.109 0 0
Potential therapeutics for SARS R-HSA-9679191 7.798978e-01 0.108 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 7.815565e-01 0.107 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 7.820493e-01 0.107 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 7.821509e-01 0.107 0 0
RAB geranylgeranylation R-HSA-8873719 7.832733e-01 0.106 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.894098e-01 0.103 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 7.894098e-01 0.103 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 7.894098e-01 0.103 0 0
Maturation of hRSV A proteins R-HSA-9828806 7.894098e-01 0.103 0 0
Removal of the Flap Intermediate R-HSA-69166 7.944419e-01 0.100 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 7.944419e-01 0.100 0 0
cGMP effects R-HSA-418457 7.944419e-01 0.100 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 7.944419e-01 0.100 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 7.944419e-01 0.100 0 0
NRIF signals cell death from the nucleus R-HSA-205043 7.944419e-01 0.100 0 0
FGFR3c ligand binding and activation R-HSA-190372 7.944419e-01 0.100 0 0
Prolactin receptor signaling R-HSA-1170546 7.944419e-01 0.100 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 7.964057e-01 0.099 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 7.983403e-01 0.098 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 7.983403e-01 0.098 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 7.983403e-01 0.098 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.991661e-01 0.097 0 0
ERK/MAPK targets R-HSA-198753 7.991661e-01 0.097 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 7.991661e-01 0.097 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 7.991661e-01 0.097 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 7.994039e-01 0.097 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 7.994039e-01 0.097 0 0
Protein ubiquitination R-HSA-8852135 7.994039e-01 0.097 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 8.017329e-01 0.096 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 8.017329e-01 0.096 0 0
Hyaluronan metabolism R-HSA-2142845 8.017329e-01 0.096 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.017329e-01 0.096 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.017329e-01 0.096 0 0
DNA Replication R-HSA-69306 8.060462e-01 0.094 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 8.066129e-01 0.093 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 8.066129e-01 0.093 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 8.066129e-01 0.093 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 8.066129e-01 0.093 0 0
FGFR3b ligand binding and activation R-HSA-190371 8.066129e-01 0.093 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 8.066129e-01 0.093 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 8.066129e-01 0.093 0 0
mRNA Editing: C to U Conversion R-HSA-72200 8.066129e-01 0.093 0 0
Attachment of GPI anchor to uPAR R-HSA-162791 8.066129e-01 0.093 0 0
LDL remodeling R-HSA-8964041 8.066129e-01 0.093 0 0
SLC-mediated transport of oligopeptides R-HSA-9959399 8.066129e-01 0.093 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 8.066129e-01 0.093 0 0
Activation of TRKA receptors R-HSA-187015 8.066129e-01 0.093 0 0
Regulation of PTEN localization R-HSA-8948747 8.066129e-01 0.093 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 8.066129e-01 0.093 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.080105e-01 0.093 0 0
HIV elongation arrest and recovery R-HSA-167287 8.080105e-01 0.093 0 0
Pausing and recovery of HIV elongation R-HSA-167290 8.080105e-01 0.093 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.080105e-01 0.093 0 0
Degradation of CRY and PER proteins R-HSA-9932298 8.135841e-01 0.090 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 8.142611e-01 0.089 0 0
Interleukin-1 signaling R-HSA-9020702 8.176679e-01 0.087 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 8.179267e-01 0.087 0 0
Regulation of Apoptosis R-HSA-169911 8.179267e-01 0.087 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 8.179267e-01 0.087 0 0
Translesion synthesis by REV1 R-HSA-110312 8.183615e-01 0.087 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.183615e-01 0.087 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 8.183615e-01 0.087 0 0
Processive synthesis on the lagging strand R-HSA-69183 8.183615e-01 0.087 0 0
FGFR3 ligand binding and activation R-HSA-190239 8.183615e-01 0.087 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.183615e-01 0.087 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.183615e-01 0.087 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.183615e-01 0.087 0 0
Signaling by Activin R-HSA-1502540 8.183615e-01 0.087 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 8.192028e-01 0.087 0 0
Signaling by PDGFR in disease R-HSA-9671555 8.192028e-01 0.087 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 8.229704e-01 0.085 0 0
Downstream TCR signaling R-HSA-202424 8.244065e-01 0.084 0 0
Signaling by Erythropoietin R-HSA-9006335 8.252484e-01 0.083 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.252484e-01 0.083 0 0
mRNA Capping R-HSA-72086 8.252484e-01 0.083 0 0
Regulation of gene expression in beta cells R-HSA-210745 8.252484e-01 0.083 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 8.289708e-01 0.081 0 0
Antigen processing-Cross presentation R-HSA-1236975 8.289708e-01 0.081 0 0
SARS-CoV Infections R-HSA-9679506 8.296425e-01 0.081 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.306301e-01 0.081 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.330392e-01 0.079 0 0
Potassium Channels R-HSA-1296071 8.353442e-01 0.078 0 0
Reverse Transcription of HIV RNA R-HSA-162589 8.359237e-01 0.078 0 0
Minus-strand DNA synthesis R-HSA-164516 8.359237e-01 0.078 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 8.359237e-01 0.078 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 8.359237e-01 0.078 0 0
Co-stimulation by ICOS R-HSA-9927354 8.359237e-01 0.078 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 8.359237e-01 0.078 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 8.359237e-01 0.078 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 8.359237e-01 0.078 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 8.359237e-01 0.078 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 8.359237e-01 0.078 0 0
TGFBR3 PTM regulation R-HSA-9839383 8.359237e-01 0.078 0 0
Nucleotide salvage defects R-HSA-9734207 8.359237e-01 0.078 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 8.359237e-01 0.078 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 8.359237e-01 0.078 0 0
Interleukin-23 signaling R-HSA-9020933 8.359237e-01 0.078 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.375107e-01 0.077 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.375107e-01 0.077 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 8.393877e-01 0.076 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.397542e-01 0.076 0 0
Translesion synthesis by POLI R-HSA-5656121 8.397542e-01 0.076 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.397542e-01 0.076 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.397542e-01 0.076 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 8.397542e-01 0.076 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 8.397542e-01 0.076 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.402357e-01 0.076 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.411829e-01 0.075 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.411829e-01 0.075 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 8.438639e-01 0.074 0 0
Degradation of AXIN R-HSA-4641257 8.471111e-01 0.072 0 0
Signaling by Insulin receptor R-HSA-74752 8.529518e-01 0.069 0 0
Eukaryotic Translation Elongation R-HSA-156842 8.529518e-01 0.069 0 0
Amine ligand-binding receptors R-HSA-375280 8.539043e-01 0.069 0 0
Switching of origins to a post-replicative state R-HSA-69052 8.540333e-01 0.069 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 8.541945e-01 0.068 0 0
Termination of O-glycan biosynthesis R-HSA-977068 8.541945e-01 0.068 0 0
Interleukin-20 family signaling R-HSA-8854691 8.541945e-01 0.068 0 0
Cap-dependent Translation Initiation R-HSA-72737 8.556596e-01 0.068 0 0
Eukaryotic Translation Initiation R-HSA-72613 8.556596e-01 0.068 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 8.558774e-01 0.068 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 8.588366e-01 0.066 0 0
Translesion synthesis by POLK R-HSA-5655862 8.588366e-01 0.066 0 0
Phase 2 - plateau phase R-HSA-5576893 8.588366e-01 0.066 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 8.588366e-01 0.066 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 8.588366e-01 0.066 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 8.588366e-01 0.066 0 0
Synthesis of PG R-HSA-1483148 8.588366e-01 0.066 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 8.588366e-01 0.066 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 8.607934e-01 0.065 0 0
Unwinding of DNA R-HSA-176974 8.607934e-01 0.065 0 0
ARMS-mediated activation R-HSA-170984 8.607934e-01 0.065 0 0
Regulation of signaling by NODAL R-HSA-1433617 8.607934e-01 0.065 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 8.607934e-01 0.065 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 8.607934e-01 0.065 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.607934e-01 0.065 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.609478e-01 0.065 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 8.656429e-01 0.063 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.693608e-01 0.061 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.693608e-01 0.061 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 8.693608e-01 0.061 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.693608e-01 0.061 0 0
Inwardly rectifying K+ channels R-HSA-1296065 8.693977e-01 0.061 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 8.693977e-01 0.061 0 0
Integration of energy metabolism R-HSA-163685 8.729580e-01 0.059 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 8.758172e-01 0.058 0 0
Sulfide oxidation to sulfate R-HSA-1614517 8.758172e-01 0.058 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.765871e-01 0.057 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 8.765871e-01 0.057 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.765871e-01 0.057 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.765871e-01 0.057 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 8.772432e-01 0.057 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.777592e-01 0.057 0 0
ER-Phagosome pathway R-HSA-1236974 8.784932e-01 0.056 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 8.815016e-01 0.055 0 0
Binding and entry of HIV virion R-HSA-173107 8.818947e-01 0.055 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 8.818947e-01 0.055 0 0
DNA replication initiation R-HSA-68952 8.818947e-01 0.055 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 8.818947e-01 0.055 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 8.818947e-01 0.055 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.818947e-01 0.055 0 0
Maturation of spike protein R-HSA-9683686 8.818947e-01 0.055 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 8.818947e-01 0.055 0 0
Pexophagy R-HSA-9664873 8.818947e-01 0.055 0 0
Tandem pore domain potassium channels R-HSA-1296346 8.818947e-01 0.055 0 0
HCMV Late Events R-HSA-9610379 8.820689e-01 0.054 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.831157e-01 0.054 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.831157e-01 0.054 0 0
Hyaluronan degradation R-HSA-2160916 8.831157e-01 0.054 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 8.852432e-01 0.053 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.866746e-01 0.052 0 0
Activated point mutants of FGFR2 R-HSA-2033519 8.908949e-01 0.050 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 8.908949e-01 0.050 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 8.931849e-01 0.049 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.931849e-01 0.049 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 8.938971e-01 0.049 0 0
Maturation of spike protein R-HSA-9694548 8.938971e-01 0.049 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.955637e-01 0.048 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 8.955637e-01 0.048 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 8.981656e-01 0.047 0 0
Telomere Maintenance R-HSA-157579 8.990997e-01 0.046 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 8.997985e-01 0.046 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.997985e-01 0.046 0 0
Conjugation of benzoate with glycine R-HSA-177135 8.997985e-01 0.046 0 0
Synthesis of PI R-HSA-1483226 8.997985e-01 0.046 0 0
Bicarbonate transporters R-HSA-425381 8.997985e-01 0.046 0 0
Transport of RCbl within the body R-HSA-9758890 8.997985e-01 0.046 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.997985e-01 0.046 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.997985e-01 0.046 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.034553e-01 0.044 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.034553e-01 0.044 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.035860e-01 0.044 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 9.042561e-01 0.044 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.042561e-01 0.044 0 0
Diseases of hemostasis R-HSA-9671793 9.042561e-01 0.044 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.042561e-01 0.044 0 0
RSV-host interactions R-HSA-9833110 9.044244e-01 0.044 0 0
Signaling by BMP R-HSA-201451 9.068060e-01 0.042 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.068060e-01 0.042 0 0
Dectin-2 family R-HSA-5621480 9.075298e-01 0.042 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.087247e-01 0.042 0 0
Cellular response to hypoxia R-HSA-1234174 9.105816e-01 0.041 0 0
GABA B receptor activation R-HSA-977444 9.122539e-01 0.040 0 0
Activation of GABAB receptors R-HSA-991365 9.122539e-01 0.040 0 0
Gastrulation R-HSA-9758941 9.129920e-01 0.040 0 0
Azathioprine ADME R-HSA-9748787 9.131454e-01 0.039 0 0
Ca2+ pathway R-HSA-4086398 9.139216e-01 0.039 0 0
DS-GAG biosynthesis R-HSA-2022923 9.149890e-01 0.039 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 9.149890e-01 0.039 0 0
Scavenging by Class H Receptors R-HSA-3000497 9.149890e-01 0.039 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 9.149890e-01 0.039 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 9.149890e-01 0.039 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 9.149890e-01 0.039 0 0
Sodium/Calcium exchangers R-HSA-425561 9.149890e-01 0.039 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 9.149890e-01 0.039 0 0
Pyruvate metabolism R-HSA-70268 9.149997e-01 0.039 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 9.160747e-01 0.038 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.160747e-01 0.038 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.160747e-01 0.038 0 0
Keratan sulfate degradation R-HSA-2022857 9.160747e-01 0.038 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.160747e-01 0.038 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.160747e-01 0.038 0 0
Glycogen synthesis R-HSA-3322077 9.160747e-01 0.038 0 0
Prednisone ADME R-HSA-9757110 9.169402e-01 0.038 0 0
Amyloid fiber formation R-HSA-977225 9.173960e-01 0.037 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.203402e-01 0.036 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.206637e-01 0.036 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.206637e-01 0.036 0 0
rRNA processing R-HSA-72312 9.223076e-01 0.035 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.260590e-01 0.033 0 0
Influenza Infection R-HSA-168255 9.264211e-01 0.033 0 0
G-protein activation R-HSA-202040 9.265113e-01 0.033 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.265113e-01 0.033 0 0
Lagging Strand Synthesis R-HSA-69186 9.265113e-01 0.033 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.265113e-01 0.033 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.265113e-01 0.033 0 0
VLDLR internalisation and degradation R-HSA-8866427 9.278774e-01 0.033 0 0
Acetylation R-HSA-156582 9.278774e-01 0.033 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 9.278774e-01 0.033 0 0
Conjugation of salicylate with glycine R-HSA-177128 9.278774e-01 0.033 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 9.278774e-01 0.033 0 0
Leading Strand Synthesis R-HSA-69109 9.278774e-01 0.033 0 0
Polymerase switching R-HSA-69091 9.278774e-01 0.033 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 9.278774e-01 0.033 0 0
tRNA Aminoacylation R-HSA-379724 9.284974e-01 0.032 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.296013e-01 0.032 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.296013e-01 0.032 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.342504e-01 0.030 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.342504e-01 0.030 0 0
Aquaporin-mediated transport R-HSA-445717 9.344975e-01 0.029 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.344975e-01 0.029 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.345578e-01 0.029 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.345578e-01 0.029 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.345578e-01 0.029 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.345578e-01 0.029 0 0
Serine metabolism R-HSA-977347 9.357132e-01 0.029 0 0
Ribavirin ADME R-HSA-9755088 9.357132e-01 0.029 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.367490e-01 0.028 0 0
Purine salvage R-HSA-74217 9.367490e-01 0.028 0 0
Translation of Structural Proteins R-HSA-9694635 9.372560e-01 0.028 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 9.380344e-01 0.028 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 9.388125e-01 0.027 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 9.388125e-01 0.027 0 0
Chylomicron remodeling R-HSA-8963901 9.388125e-01 0.027 0 0
Processing of SMDT1 R-HSA-8949664 9.388125e-01 0.027 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 9.388125e-01 0.027 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 9.388125e-01 0.027 0 0
Signaling by PDGF R-HSA-186797 9.400499e-01 0.027 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.407768e-01 0.027 0 0
COPII-mediated vesicle transport R-HSA-204005 9.408749e-01 0.026 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.415969e-01 0.026 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.432308e-01 0.025 0 0
Free fatty acid receptors R-HSA-444209 9.438149e-01 0.025 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.438149e-01 0.025 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.438149e-01 0.025 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.438948e-01 0.025 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.438948e-01 0.025 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.438948e-01 0.025 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.448984e-01 0.025 0 0
G alpha (z) signalling events R-HSA-418597 9.453206e-01 0.024 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.480804e-01 0.023 0 0
Retrograde neurotrophin signalling R-HSA-177504 9.480901e-01 0.023 0 0
HDL assembly R-HSA-8963896 9.480901e-01 0.023 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 9.480901e-01 0.023 0 0
Signaling by FGFR4 in disease R-HSA-5655291 9.480901e-01 0.023 0 0
Hydrolysis of LPC R-HSA-1483115 9.480901e-01 0.023 0 0
N-glycan trimming and elongation in the cis-Golgi R-HSA-964739 9.480901e-01 0.023 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 9.480901e-01 0.023 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.480901e-01 0.023 0 0
Non-canonical inflammasome activation R-HSA-9686114 9.480901e-01 0.023 0 0
Acyl chain remodeling of CL R-HSA-1482798 9.480901e-01 0.023 0 0
Zinc transporters R-HSA-435354 9.480901e-01 0.023 0 0
P2Y receptors R-HSA-417957 9.480901e-01 0.023 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 9.480901e-01 0.023 0 0
DNA strand elongation R-HSA-69190 9.481757e-01 0.023 0 0
Glycogen metabolism R-HSA-8982491 9.491002e-01 0.023 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.509382e-01 0.022 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.509382e-01 0.022 0 0
ABC-family proteins mediated transport R-HSA-382556 9.511157e-01 0.022 0 0
Synthesis of DNA R-HSA-69239 9.528179e-01 0.021 0 0
Protein localization R-HSA-9609507 9.545668e-01 0.020 0 0
G alpha (q) signalling events R-HSA-416476 9.548486e-01 0.020 0 0
Peptide chain elongation R-HSA-156902 9.557052e-01 0.020 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.559614e-01 0.020 0 0
Telomere C-strand synthesis initiation R-HSA-174430 9.559614e-01 0.020 0 0
Synthesis of 12-eicosatetraenoic acid derivatives R-HSA-2142712 9.559614e-01 0.020 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.559614e-01 0.020 0 0
Transport and metabolism of PAPS R-HSA-174362 9.559614e-01 0.020 0 0
Biotin transport and metabolism R-HSA-196780 9.559614e-01 0.020 0 0
Formation of the anterior neural plate R-HSA-9823739 9.559614e-01 0.020 0 0
DNA Damage Reversal R-HSA-73942 9.559614e-01 0.020 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.563641e-01 0.019 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.571937e-01 0.019 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.571937e-01 0.019 0 0
Complex III assembly R-HSA-9865881 9.571937e-01 0.019 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.571937e-01 0.019 0 0
Signaling by FGFR in disease R-HSA-1226099 9.581922e-01 0.019 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.592006e-01 0.018 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.592006e-01 0.018 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.592006e-01 0.018 0 0
Translation of Structural Proteins R-HSA-9683701 9.592006e-01 0.018 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.593120e-01 0.018 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.593120e-01 0.018 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.593120e-01 0.018 0 0
PPARA activates gene expression R-HSA-1989781 9.599111e-01 0.018 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.600368e-01 0.018 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.619054e-01 0.017 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.619054e-01 0.017 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.626396e-01 0.017 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 9.626396e-01 0.017 0 0
Attachment and Entry R-HSA-9678110 9.626396e-01 0.017 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.626807e-01 0.017 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.626807e-01 0.017 0 0
G protein gated Potassium channels R-HSA-1296059 9.626807e-01 0.017 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 9.626807e-01 0.017 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.628733e-01 0.016 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.631376e-01 0.016 0 0
eNOS activation R-HSA-203615 9.639973e-01 0.016 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.639973e-01 0.016 0 0
MET activates PTK2 signaling R-HSA-8874081 9.674883e-01 0.014 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.674883e-01 0.014 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.674883e-01 0.014 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.681706e-01 0.014 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.681706e-01 0.014 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 9.683054e-01 0.014 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.683054e-01 0.014 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.683054e-01 0.014 0 0
Scavenging by Class B Receptors R-HSA-3000471 9.683054e-01 0.014 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 9.683054e-01 0.014 0 0
Vitamin B6 activation to pyridoxal phosphate R-HSA-964975 9.683054e-01 0.014 0 0
Coenzyme A biosynthesis R-HSA-196783 9.683054e-01 0.014 0 0
Fibronectin matrix formation R-HSA-1566977 9.683054e-01 0.014 0 0
Formation of xylulose-5-phosphate R-HSA-5661270 9.683054e-01 0.014 0 0
Galactose catabolism R-HSA-70370 9.683054e-01 0.014 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.683054e-01 0.014 0 0
Response to metal ions R-HSA-5660526 9.683054e-01 0.014 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.683054e-01 0.014 0 0
Regulation of insulin secretion R-HSA-422356 9.685789e-01 0.014 0 0
Ribosome-associated quality control R-HSA-9948299 9.693862e-01 0.014 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.697133e-01 0.013 0 0
ABC transporter disorders R-HSA-5619084 9.708132e-01 0.013 0 0
Proteasome assembly R-HSA-9907900 9.709202e-01 0.013 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.709202e-01 0.013 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.716964e-01 0.012 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.718837e-01 0.012 0 0
Triglyceride catabolism R-HSA-163560 9.718837e-01 0.012 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.731122e-01 0.012 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.731122e-01 0.012 0 0
Synthesis of 15-eicosatetraenoic acid derivatives R-HSA-2142770 9.731122e-01 0.012 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.731122e-01 0.012 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.731122e-01 0.012 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.740685e-01 0.011 0 0
Telomere Extension By Telomerase R-HSA-171319 9.753762e-01 0.011 0 0
Insulin receptor recycling R-HSA-77387 9.753762e-01 0.011 0 0
Pyrimidine salvage R-HSA-73614 9.753762e-01 0.011 0 0
tRNA processing R-HSA-72306 9.771038e-01 0.010 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 9.771903e-01 0.010 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.771903e-01 0.010 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.771903e-01 0.010 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.771903e-01 0.010 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.773495e-01 0.010 0 0
Innate Immune System R-HSA-168249 9.778941e-01 0.010 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.785911e-01 0.009 0 0
DARPP-32 events R-HSA-180024 9.785911e-01 0.009 0 0
Glucagon-type ligand receptors R-HSA-420092 9.785911e-01 0.009 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.791470e-01 0.009 0 0
Eukaryotic Translation Termination R-HSA-72764 9.792346e-01 0.009 0 0
Pyrimidine biosynthesis R-HSA-500753 9.806500e-01 0.008 0 0
Specification of the neural plate border R-HSA-9834899 9.806500e-01 0.008 0 0
Amino Acid conjugation R-HSA-156587 9.806500e-01 0.008 0 0
Conjugation of carboxylic acids R-HSA-159424 9.806500e-01 0.008 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.806500e-01 0.008 0 0
E2F mediated regulation of DNA replication R-HSA-113510 9.806500e-01 0.008 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.806500e-01 0.008 0 0
Transport of nucleotide sugars R-HSA-727802 9.806500e-01 0.008 0 0
HDL remodeling R-HSA-8964058 9.806500e-01 0.008 0 0
Crosslinking of collagen fibrils R-HSA-2243919 9.806500e-01 0.008 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.806500e-01 0.008 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.807111e-01 0.008 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.807111e-01 0.008 0 0
Neurotransmitter clearance R-HSA-112311 9.813975e-01 0.008 0 0
Synthesis of PA R-HSA-1483166 9.814070e-01 0.008 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.817364e-01 0.008 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.819436e-01 0.008 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.828556e-01 0.008 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.835851e-01 0.007 0 0
Cargo concentration in the ER R-HSA-5694530 9.838453e-01 0.007 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.838453e-01 0.007 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.840610e-01 0.007 0 0
Extension of Telomeres R-HSA-180786 9.850949e-01 0.007 0 0
Peroxisomal protein import R-HSA-9033241 9.850949e-01 0.007 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.857487e-01 0.006 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.860752e-01 0.006 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.860752e-01 0.006 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.860752e-01 0.006 0 0
GABA receptor activation R-HSA-977443 9.866690e-01 0.006 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.866690e-01 0.006 0 0
Integrin cell surface interactions R-HSA-216083 9.870038e-01 0.006 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.870190e-01 0.006 0 0
Nucleotide salvage R-HSA-8956321 9.880850e-01 0.005 0 0
CS-GAG biosynthesis R-HSA-2022870 9.881877e-01 0.005 0 0
Eicosanoids R-HSA-211979 9.881877e-01 0.005 0 0
Miscellaneous substrates R-HSA-211958 9.881877e-01 0.005 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.881877e-01 0.005 0 0
Glutathione synthesis and recycling R-HSA-174403 9.881877e-01 0.005 0 0
Attachment and Entry R-HSA-9694614 9.881877e-01 0.005 0 0
Cellular response to starvation R-HSA-9711097 9.883592e-01 0.005 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.884446e-01 0.005 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.884446e-01 0.005 0 0
Orc1 removal from chromatin R-HSA-68949 9.886186e-01 0.005 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.892366e-01 0.005 0 0
Metabolism of cofactors R-HSA-8978934 9.892366e-01 0.005 0 0
SLC transporter disorders R-HSA-5619102 9.894399e-01 0.005 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.894539e-01 0.005 0 0
Heme degradation R-HSA-189483 9.894539e-01 0.005 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.894539e-01 0.005 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.899100e-01 0.004 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 9.899797e-01 0.004 0 0
LDL clearance R-HSA-8964038 9.899797e-01 0.004 0 0
Reactions specific to the complex N-glycan synthesis pathway R-HSA-975578 9.899797e-01 0.004 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.899797e-01 0.004 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.908604e-01 0.004 0 0
Neddylation R-HSA-8951664 9.914402e-01 0.004 0 0
Fatty acids R-HSA-211935 9.915000e-01 0.004 0 0
Formation of the ureteric bud R-HSA-9830674 9.915000e-01 0.004 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.915000e-01 0.004 0 0
Carnitine shuttle R-HSA-200425 9.915000e-01 0.004 0 0
Biosynthesis of maresins R-HSA-9018682 9.915000e-01 0.004 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.920830e-01 0.003 0 0
Paracetamol ADME R-HSA-9753281 9.920850e-01 0.003 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 9.927897e-01 0.003 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.927897e-01 0.003 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.931451e-01 0.003 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.934040e-01 0.003 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.938838e-01 0.003 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.938838e-01 0.003 0 0
Retinoid cycle disease events R-HSA-2453864 9.938838e-01 0.003 0 0
Diseases associated with visual transduction R-HSA-2474795 9.938838e-01 0.003 0 0
Diseases of the neuronal system R-HSA-9675143 9.938838e-01 0.003 0 0
Laminin interactions R-HSA-3000157 9.938838e-01 0.003 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.938838e-01 0.003 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.940077e-01 0.003 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.940672e-01 0.003 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.940672e-01 0.003 0 0
Collagen chain trimerization R-HSA-8948216 9.940672e-01 0.003 0 0
FCGR activation R-HSA-2029481 9.943964e-01 0.002 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.945256e-01 0.002 0 0
Selenocysteine synthesis R-HSA-2408557 9.945445e-01 0.002 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.947395e-01 0.002 0 0
Metal ion SLC transporters R-HSA-425410 9.947395e-01 0.002 0 0
Urea cycle R-HSA-70635 9.948119e-01 0.002 0 0
Abacavir ADME R-HSA-2161522 9.948119e-01 0.002 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.948674e-01 0.002 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.951642e-01 0.002 0 0
Triglyceride metabolism R-HSA-8979227 9.951642e-01 0.002 0 0
Viral mRNA Translation R-HSA-192823 9.955279e-01 0.002 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.955992e-01 0.002 0 0
Triglyceride biosynthesis R-HSA-75109 9.955992e-01 0.002 0 0
Insulin processing R-HSA-264876 9.955992e-01 0.002 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.955992e-01 0.002 0 0
Glutathione conjugation R-HSA-156590 9.957307e-01 0.002 0 0
Metabolism of polyamines R-HSA-351202 9.957307e-01 0.002 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.959706e-01 0.002 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.960679e-01 0.002 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.961630e-01 0.002 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.962937e-01 0.002 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.966748e-01 0.001 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.966843e-01 0.001 0 0
Thyroxine biosynthesis R-HSA-209968 9.968337e-01 0.001 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.968337e-01 0.001 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.968337e-01 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 9.973085e-01 0.001 0 0
Mucopolysaccharidoses R-HSA-2206281 9.973143e-01 0.001 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.973335e-01 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.973826e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.976037e-01 0.001 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.976304e-01 0.001 0 0
Glucuronidation R-HSA-156588 9.976493e-01 0.001 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.977219e-01 0.001 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.977219e-01 0.001 0 0
Extracellular matrix organization R-HSA-1474244 9.977560e-01 0.001 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.980678e-01 0.001 0 0
Mitochondrial protein degradation R-HSA-9837999 9.980959e-01 0.001 0 0
Collagen formation R-HSA-1474290 9.980959e-01 0.001 0 0
Kidney development R-HSA-9830369 9.982403e-01 0.001 0 0
Keratan sulfate biosynthesis R-HSA-2022854 9.983611e-01 0.001 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.983611e-01 0.001 0 0
Infectious disease R-HSA-5663205 9.984042e-01 0.001 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.984103e-01 0.001 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.984103e-01 0.001 0 0
CS/DS degradation R-HSA-2024101 9.986099e-01 0.001 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.986290e-01 0.001 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.988179e-01 0.001 0 0
Synthesis of PC R-HSA-1483191 9.988179e-01 0.001 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.988210e-01 0.001 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.988210e-01 0.001 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.988210e-01 0.001 0 0
Neurotransmitter release cycle R-HSA-112310 9.988795e-01 0.000 0 0
Disease R-HSA-1643685 9.989155e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.990993e-01 0.000 0 0
Keratan sulfate/keratin metabolism R-HSA-1638074 9.991219e-01 0.000 0 0
Glycosphingolipid transport R-HSA-9845576 9.991518e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.991543e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.991913e-01 0.000 0 0
Keratinization R-HSA-6805567 9.992443e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.992709e-01 0.000 0 0
Ubiquinol biosynthesis R-HSA-2142789 9.992806e-01 0.000 0 0
NCAM1 interactions R-HSA-419037 9.992806e-01 0.000 0 0
Metabolism of folate and pterines R-HSA-196757 9.992806e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.993484e-01 0.000 0 0
The phototransduction cascade R-HSA-2514856 9.993484e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.993779e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.993779e-01 0.000 0 0
Elastic fibre formation R-HSA-1566948 9.993899e-01 0.000 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.994825e-01 0.000 0 0
RAS processing R-HSA-9648002 9.994825e-01 0.000 0 0
N-glycan antennae elongation in the medial/trans-Golgi R-HSA-975576 9.995611e-01 0.000 0 0
Tryptophan catabolism R-HSA-71240 9.995611e-01 0.000 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.995611e-01 0.000 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.996278e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.996380e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.996380e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.996609e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.996609e-01 0.000 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.996843e-01 0.000 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.997729e-01 0.000 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.997833e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.998073e-01 0.000 0 0
Surfactant metabolism R-HSA-5683826 9.998074e-01 0.000 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.998074e-01 0.000 0 0
Methylation R-HSA-156581 9.998074e-01 0.000 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.998074e-01 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 9.998319e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.998331e-01 0.000 0 0
The canonical retinoid cycle in rods (twilight vision) R-HSA-2453902 9.998367e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.998749e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.998844e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.998989e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.999083e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.999083e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.999155e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.999181e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.999181e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.999268e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.999291e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999377e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.999420e-01 0.000 0 0
Translation R-HSA-72766 9.999435e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999468e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999482e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999490e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.999633e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999685e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.999685e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.999685e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.999686e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999727e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.999734e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999768e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.999801e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999841e-01 0.000 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.999862e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999875e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.999883e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999908e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.999916e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999924e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999957e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999958e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999959e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999971e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999973e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999980e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999980e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999989e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999992e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999993e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999996e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999996e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999996e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999998e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999999e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999999e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999999e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999999e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Visual phototransduction R-HSA-2187338 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 1.000000e+00 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.110223e-16 15.955 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.110223e-16 15.955 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.110223e-16 15.955 0 0
M Phase R-HSA-68886 1.110223e-16 15.955 1 0
Axon guidance R-HSA-422475 1.110223e-16 15.955 0 0
Nervous system development R-HSA-9675108 1.110223e-16 15.955 0 0
Metabolism of RNA R-HSA-8953854 1.110223e-16 15.955 0 0
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 1 0
Cell Cycle, Mitotic R-HSA-69278 1.110223e-16 15.955 1 0
Cell-Cell communication R-HSA-1500931 1.110223e-16 15.955 0 0
Cellular responses to stress R-HSA-2262752 1.110223e-16 15.955 0 0
Cellular responses to stimuli R-HSA-8953897 1.110223e-16 15.955 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.330669e-16 15.477 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.443290e-15 14.841 0 0
Mitotic Anaphase R-HSA-68882 4.996004e-15 14.301 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 6.106227e-15 14.214 0 0
Signaling by ROBO receptors R-HSA-376176 9.214851e-15 14.036 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.121325e-14 13.950 0 0
Separation of Sister Chromatids R-HSA-2467813 2.320366e-14 13.634 0 0
Cell junction organization R-HSA-446728 7.016610e-14 13.154 0 0
Influenza Infection R-HSA-168255 6.894485e-14 13.161 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.980905e-14 13.001 0 0
Peptide chain elongation R-HSA-156902 1.119105e-13 12.951 0 0
Interleukin-12 signaling R-HSA-9020591 1.367795e-13 12.864 0 0
Mitotic Prometaphase R-HSA-68877 3.713696e-13 12.430 1 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 3.885781e-13 12.411 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 5.088152e-13 12.293 0 0
Translation initiation complex formation R-HSA-72649 5.381251e-13 12.269 0 0
Ribosome-associated quality control R-HSA-9948299 9.174883e-13 12.037 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.011857e-12 11.995 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.000533e-12 12.000 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.000533e-12 12.000 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.196265e-12 11.922 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.266764e-12 11.897 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.314615e-12 11.881 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.446687e-12 11.463 0 0
Cellular response to heat stress R-HSA-3371556 4.318879e-12 11.365 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.917178e-12 11.308 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 5.083378e-12 11.294 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 6.264544e-12 11.203 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 6.264544e-12 11.203 0 0
Interleukin-12 family signaling R-HSA-447115 6.273759e-12 11.202 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 7.284839e-12 11.138 0 0
Cell Cycle Checkpoints R-HSA-69620 8.148260e-12 11.089 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.069189e-11 10.971 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.170697e-11 10.932 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.513667e-11 10.820 0 0
Eukaryotic Translation Termination R-HSA-72764 2.578326e-11 10.589 0 0
Viral Infection Pathways R-HSA-9824446 3.517320e-11 10.454 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 8.333656e-11 10.079 1 1
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 8.602652e-11 10.065 0 0
Apoptotic execution phase R-HSA-75153 8.602652e-11 10.065 0 0
Selenocysteine synthesis R-HSA-2408557 1.196903e-10 9.922 0 0
Mitotic Prophase R-HSA-68875 1.394315e-10 9.856 1 0
Viral mRNA Translation R-HSA-192823 1.947724e-10 9.710 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.261770e-10 9.646 0 0
Nucleosome assembly R-HSA-774815 2.972090e-10 9.527 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 2.972090e-10 9.527 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 3.324447e-10 9.478 0 0
Cell-cell junction organization R-HSA-421270 3.294069e-10 9.482 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.712288e-10 9.430 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 5.306563e-10 9.275 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 5.396908e-10 9.268 0 0
Assembly of the pre-replicative complex R-HSA-68867 6.116367e-10 9.214 0 0
Adherens junctions interactions R-HSA-418990 7.233136e-10 9.141 0 0
Aggrephagy R-HSA-9646399 7.576824e-10 9.121 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 8.377633e-10 9.077 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.113946e-09 8.953 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.684438e-09 8.774 0 0
HDACs deacetylate histones R-HSA-3214815 2.065366e-09 8.685 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.524764e-09 8.598 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 3.869588e-09 8.412 0 0
Meiotic synapsis R-HSA-1221632 4.782281e-09 8.320 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.782281e-09 8.320 0 0
rRNA processing R-HSA-72312 5.409176e-09 8.267 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 5.718188e-09 8.243 0 0
Diseases of programmed cell death R-HSA-9645723 6.473701e-09 8.189 0 0
HCMV Early Events R-HSA-9609690 6.900707e-09 8.161 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 9.493477e-09 8.023 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.036836e-08 7.984 0 0
Recycling pathway of L1 R-HSA-437239 1.351114e-08 7.869 0 0
Selenoamino acid metabolism R-HSA-2408522 1.415383e-08 7.849 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.501845e-08 7.823 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.678044e-08 7.775 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.678044e-08 7.775 0 0
Selective autophagy R-HSA-9663891 2.239618e-08 7.650 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.973534e-08 7.527 0 0
Translation R-HSA-72766 3.315390e-08 7.479 0 0
Cellular response to starvation R-HSA-9711097 3.918456e-08 7.407 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 5.057714e-08 7.296 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 5.545405e-08 7.256 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 5.642021e-08 7.249 0 0
L1CAM interactions R-HSA-373760 5.961693e-08 7.225 0 0
Regulation of endogenous retroelements R-HSA-9842860 6.369662e-08 7.196 0 0
Ub-specific processing proteases R-HSA-5689880 6.545625e-08 7.184 0 0
Cellular Senescence R-HSA-2559583 7.127123e-08 7.147 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 8.198510e-08 7.086 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 8.183937e-08 7.087 0 0
Attenuation phase R-HSA-3371568 8.825370e-08 7.054 0 0
Cell-extracellular matrix interactions R-HSA-446353 8.826473e-08 7.054 0 0
Deubiquitination R-HSA-5688426 1.008287e-07 6.996 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.042094e-07 6.982 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.123059e-07 6.950 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.526993e-07 6.816 0 0
G2/M Transition R-HSA-69275 1.648873e-07 6.783 0 0
Striated Muscle Contraction R-HSA-390522 1.718240e-07 6.765 0 0
G2/M Checkpoints R-HSA-69481 1.720272e-07 6.764 0 0
HSF1-dependent transactivation R-HSA-3371571 1.919482e-07 6.717 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.953580e-07 6.709 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.161166e-07 6.665 0 0
DNA Double Strand Break Response R-HSA-5693606 2.313551e-07 6.636 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.385388e-07 6.622 0 0
Regulation of CDH1 Function R-HSA-9764561 2.520124e-07 6.599 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.752820e-07 6.560 0 0
HCMV Infection R-HSA-9609646 2.802813e-07 6.552 0 0
Packaging Of Telomere Ends R-HSA-171306 3.107566e-07 6.508 0 0
ESR-mediated signaling R-HSA-8939211 3.080469e-07 6.511 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 3.107566e-07 6.508 0 0
PKR-mediated signaling R-HSA-9833482 3.824646e-07 6.417 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 3.824646e-07 6.417 0 0
Muscle contraction R-HSA-397014 4.073781e-07 6.390 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.344910e-07 6.362 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 4.541136e-07 6.343 0 0
mRNA Splicing - Major Pathway R-HSA-72163 4.741828e-07 6.324 0 0
Apoptosis R-HSA-109581 4.707422e-07 6.327 0 0
HSF1 activation R-HSA-3371511 4.811139e-07 6.318 0 0
SARS-CoV-1 Infection R-HSA-9678108 5.348826e-07 6.272 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 5.749890e-07 6.240 0 0
Gene Silencing by RNA R-HSA-211000 5.879058e-07 6.231 0 0
DNA methylation R-HSA-5334118 6.651818e-07 6.177 0 0
Transport of connexons to the plasma membrane R-HSA-190872 7.402855e-07 6.131 0 0
Developmental Biology R-HSA-1266738 8.392064e-07 6.076 0 0
Nuclear Envelope Breakdown R-HSA-2980766 9.342501e-07 6.030 1 0
Mitotic Spindle Checkpoint R-HSA-69618 1.179289e-06 5.928 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.193136e-06 5.923 0 0
Defective pyroptosis R-HSA-9710421 1.288456e-06 5.890 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.399879e-06 5.854 0 0
Host Interactions of HIV factors R-HSA-162909 1.787337e-06 5.748 0 0
Signal Transduction R-HSA-162582 1.787382e-06 5.748 0 0
mRNA Splicing R-HSA-72172 1.821062e-06 5.740 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.892283e-06 5.723 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.184269e-06 5.661 0 0
Chromatin modifying enzymes R-HSA-3247509 2.309255e-06 5.637 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.319236e-06 5.635 0 0
Chromatin organization R-HSA-4839726 2.516714e-06 5.599 0 0
RNA Polymerase I Transcription R-HSA-73864 2.583727e-06 5.588 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 2.844902e-06 5.546 0 0
Meiosis R-HSA-1500620 3.276106e-06 5.485 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.360130e-06 5.474 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.947488e-06 5.404 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.947488e-06 5.404 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.459675e-06 5.351 0 0
Programmed Cell Death R-HSA-5357801 4.511548e-06 5.346 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 4.555880e-06 5.341 0 0
Signaling by ALK in cancer R-HSA-9700206 4.555880e-06 5.341 0 0
Processing of DNA double-strand break ends R-HSA-5693607 4.626525e-06 5.335 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 4.839929e-06 5.315 0 0
DNA Double-Strand Break Repair R-HSA-5693532 4.868267e-06 5.313 0 0
DNA Replication R-HSA-69306 4.868267e-06 5.313 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 4.872255e-06 5.312 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.387091e-06 5.269 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 6.224963e-06 5.206 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 6.660349e-06 5.177 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 6.660349e-06 5.177 0 0
Autophagy R-HSA-9612973 7.144514e-06 5.146 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 7.588557e-06 5.120 0 0
TCF dependent signaling in response to WNT R-HSA-201681 7.778807e-06 5.109 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 8.705329e-06 5.060 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.705329e-06 5.060 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 9.231109e-06 5.035 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 9.775943e-06 5.010 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.050352e-05 4.979 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.141680e-05 4.942 0 0
Cleavage of the damaged purine R-HSA-110331 1.151646e-05 4.939 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.249662e-05 4.903 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.296008e-05 4.887 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.576965e-05 4.802 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.631137e-05 4.788 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.508248e-05 4.822 0 0
Smooth Muscle Contraction R-HSA-445355 1.562722e-05 4.806 0 0
Post NMDA receptor activation events R-HSA-438064 1.619040e-05 4.791 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.631137e-05 4.788 0 0
Depurination R-HSA-73927 1.508248e-05 4.822 0 0
SARS-CoV Infections R-HSA-9679506 1.533649e-05 4.814 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.706339e-05 4.768 0 0
HIV Life Cycle R-HSA-162587 1.855415e-05 4.732 0 0
Interferon Signaling R-HSA-913531 1.886500e-05 4.724 0 0
Nuclear import of Rev protein R-HSA-180746 1.992727e-05 4.701 0 0
Signaling by ERBB2 R-HSA-1227986 2.112473e-05 4.675 0 0
HIV Infection R-HSA-162906 2.133884e-05 4.671 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.303169e-05 4.638 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.378735e-05 4.624 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.753602e-05 4.560 0 0
Macroautophagy R-HSA-1632852 2.817225e-05 4.550 0 0
Homology Directed Repair R-HSA-5693538 3.094610e-05 4.509 0 0
G2/M DNA damage checkpoint R-HSA-69473 3.293475e-05 4.482 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 3.756751e-05 4.425 0 0
Meiotic recombination R-HSA-912446 3.363804e-05 4.473 0 0
Neutrophil degranulation R-HSA-6798695 4.021909e-05 4.396 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 4.114999e-05 4.386 0 0
EPH-Ephrin signaling R-HSA-2682334 4.261056e-05 4.370 0 0
Chaperonin-mediated protein folding R-HSA-390466 4.441608e-05 4.352 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 4.482888e-05 4.348 0 0
SARS-CoV-2 Infection R-HSA-9694516 4.542584e-05 4.343 0 0
Chromosome Maintenance R-HSA-73886 4.611535e-05 4.336 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 4.995000e-05 4.301 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 5.198010e-05 4.284 0 0
Depyrimidination R-HSA-73928 5.198010e-05 4.284 0 0
HATs acetylate histones R-HSA-3214847 5.437938e-05 4.265 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 5.587561e-05 4.253 0 0
Neurodegenerative Diseases R-HSA-8863678 5.703105e-05 4.244 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 5.703105e-05 4.244 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 5.703105e-05 4.244 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 5.980746e-05 4.223 0 0
Glycolysis R-HSA-70171 6.279998e-05 4.202 0 0
Kinesins R-HSA-983189 6.539447e-05 4.184 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 7.162412e-05 4.145 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 7.895262e-05 4.103 0 0
Late Phase of HIV Life Cycle R-HSA-162599 8.067070e-05 4.093 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 7.640526e-05 4.117 0 0
Gap junction trafficking and regulation R-HSA-157858 7.193308e-05 4.143 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 7.162412e-05 4.145 0 0
Gap junction trafficking R-HSA-190828 8.139448e-05 4.089 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 8.323472e-05 4.080 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 9.045239e-05 4.044 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 9.816631e-05 4.008 1 1
KEAP1-NFE2L2 pathway R-HSA-9755511 1.009484e-04 3.996 0 0
Amyloid fiber formation R-HSA-977225 1.057512e-04 3.976 0 0
Protein ubiquitination R-HSA-8852135 1.097263e-04 3.960 0 0
Protein folding R-HSA-391251 1.101944e-04 3.958 0 0
Semaphorin interactions R-HSA-373755 1.133048e-04 3.946 0 0
Ephrin signaling R-HSA-3928664 1.191749e-04 3.924 0 0
UCH proteinases R-HSA-5689603 1.288909e-04 3.890 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.314374e-04 3.881 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.374590e-04 3.862 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.576552e-04 3.802 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.631786e-04 3.787 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.714407e-04 3.766 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.840939e-04 3.735 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.904246e-04 3.720 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 2.156526e-04 3.666 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.181315e-04 3.661 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.181315e-04 3.661 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.215009e-04 3.655 0 0
Degradation of CDH1 R-HSA-9766229 2.261684e-04 3.646 0 0
Nephrin family interactions R-HSA-373753 2.306749e-04 3.637 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 2.458543e-04 3.609 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 2.468219e-04 3.608 0 0
Infectious disease R-HSA-5663205 2.535149e-04 3.596 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.713306e-04 3.567 0 0
Gap junction assembly R-HSA-190861 2.753083e-04 3.560 0 0
DNA Repair R-HSA-73894 2.974006e-04 3.527 0 0
Cilium Assembly R-HSA-5617833 2.997830e-04 3.523 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.000825e-04 3.523 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.042732e-04 3.517 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.091885e-04 3.510 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 3.523168e-04 3.453 0 0
Folding of actin by CCT/TriC R-HSA-390450 3.523168e-04 3.453 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 3.523168e-04 3.453 0 0
Hedgehog 'off' state R-HSA-5610787 3.701094e-04 3.432 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 3.819074e-04 3.418 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 3.819074e-04 3.418 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.892887e-04 3.410 0 0
Metalloprotease DUBs R-HSA-5689901 4.095652e-04 3.388 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 4.225543e-04 3.374 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 4.287262e-04 3.368 0 0
Base Excision Repair R-HSA-73884 4.450186e-04 3.352 0 0
AURKA Activation by TPX2 R-HSA-8854518 5.153837e-04 3.288 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 5.281079e-04 3.277 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 5.293537e-04 3.276 0 0
Platelet degranulation R-HSA-114608 5.346567e-04 3.272 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 5.444047e-04 3.264 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 5.560211e-04 3.255 0 0
Switching of origins to a post-replicative state R-HSA-69052 5.633623e-04 3.249 0 0
Signaling by WNT R-HSA-195721 5.812985e-04 3.236 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 5.925261e-04 3.227 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 6.029152e-04 3.220 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 6.029152e-04 3.220 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 6.062366e-04 3.217 0 0
Spry regulation of FGF signaling R-HSA-1295596 6.845961e-04 3.165 0 0
Co-inhibition by PD-1 R-HSA-389948 7.060173e-04 3.151 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 7.106977e-04 3.148 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 8.619576e-04 3.065 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 8.117457e-04 3.091 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 8.595758e-04 3.066 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 8.595758e-04 3.066 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 8.117457e-04 3.091 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 8.585736e-04 3.066 0 0
RMTs methylate histone arginines R-HSA-3214858 8.053150e-04 3.094 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 7.485458e-04 3.126 0 0
Glucose metabolism R-HSA-70326 7.541095e-04 3.123 0 0
Reproduction R-HSA-1474165 8.083917e-04 3.092 0 0
Membrane Trafficking R-HSA-199991 8.924592e-04 3.049 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 9.626360e-04 3.017 0 0
Signaling by Nuclear Receptors R-HSA-9006931 9.813043e-04 3.008 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 9.862832e-04 3.006 0 0
Signaling by Interleukins R-HSA-449147 1.019150e-03 2.992 0 0
Orc1 removal from chromatin R-HSA-68949 1.110641e-03 2.954 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 1.110641e-03 2.954 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.145037e-03 2.941 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.145037e-03 2.941 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.145037e-03 2.941 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.145037e-03 2.941 0 0
Signaling by RAS mutants R-HSA-6802949 1.145037e-03 2.941 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.153324e-03 2.938 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.180864e-03 2.928 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.194479e-03 2.923 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.194479e-03 2.923 0 0
Metabolism of non-coding RNA R-HSA-194441 1.232932e-03 2.909 0 0
snRNP Assembly R-HSA-191859 1.232932e-03 2.909 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.270800e-03 2.896 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.270800e-03 2.896 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.270800e-03 2.896 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.302642e-03 2.885 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 1.302642e-03 2.885 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.309879e-03 2.883 0 0
S Phase R-HSA-69242 1.336142e-03 2.874 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.338744e-03 2.873 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 1.355557e-03 2.868 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.382562e-03 2.859 0 0
MAP2K and MAPK activation R-HSA-5674135 1.382562e-03 2.859 0 0
HCMV Late Events R-HSA-9610379 1.522391e-03 2.817 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.646975e-03 2.783 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.650508e-03 2.782 0 0
Nucleotide Excision Repair R-HSA-5696398 1.656009e-03 2.781 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.656975e-03 2.781 0 0
Degradation of DVL R-HSA-4641258 1.656975e-03 2.781 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.770943e-03 2.752 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.819478e-03 2.740 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.857937e-03 2.731 0 0
Signaling by VEGF R-HSA-194138 1.875448e-03 2.727 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.994457e-03 2.700 0 0
Josephin domain DUBs R-HSA-5689877 1.994457e-03 2.700 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 2.053254e-03 2.688 0 0
Signaling by EGFR R-HSA-177929 2.053254e-03 2.688 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.128943e-03 2.672 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.186815e-03 2.660 0 0
Signaling by PTK6 R-HSA-8848021 2.186815e-03 2.660 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.261971e-03 2.646 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.266329e-03 2.645 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 2.266329e-03 2.645 0 0
PECAM1 interactions R-HSA-210990 2.867891e-03 2.542 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 3.045752e-03 2.516 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 3.045752e-03 2.516 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.910965e-03 2.536 0 0
Late endosomal microautophagy R-HSA-9615710 2.818678e-03 2.550 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.816370e-03 2.550 0 0
Telomere Maintenance R-HSA-157579 2.904391e-03 2.537 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.816370e-03 2.550 0 0
Activation of HOX genes during differentiation R-HSA-5619507 3.141049e-03 2.503 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 3.141049e-03 2.503 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.655061e-03 2.576 0 0
TCR signaling R-HSA-202403 2.762840e-03 2.559 0 0
Signaling by NOTCH R-HSA-157118 2.543886e-03 2.595 0 0
Cellular response to chemical stress R-HSA-9711123 3.208851e-03 2.494 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.317685e-03 2.479 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.324209e-03 2.478 0 0
Regulation of PTEN localization R-HSA-8948747 3.330188e-03 2.478 0 0
Regulation of Apoptosis R-HSA-169911 3.427599e-03 2.465 0 0
Signaling by Hedgehog R-HSA-5358351 3.663719e-03 2.436 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 3.687795e-03 2.433 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.710372e-03 2.431 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 3.710372e-03 2.431 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 3.903543e-03 2.409 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 3.903543e-03 2.409 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 3.921244e-03 2.407 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 3.999896e-03 2.398 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 3.999896e-03 2.398 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 4.015112e-03 2.396 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.045204e-03 2.393 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.045204e-03 2.393 0 0
RET signaling R-HSA-8853659 4.073438e-03 2.390 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.173318e-03 2.380 0 0
Centrosome maturation R-HSA-380287 4.206499e-03 2.376 0 0
Intraflagellar transport R-HSA-5620924 4.254090e-03 2.371 0 0
ER to Golgi Anterograde Transport R-HSA-199977 4.425216e-03 2.354 0 0
Platelet activation, signaling and aggregation R-HSA-76002 4.582221e-03 2.339 0 0
Antigen processing-Cross presentation R-HSA-1236975 4.624633e-03 2.335 0 0
tRNA processing in the nucleus R-HSA-6784531 4.641277e-03 2.333 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 4.641277e-03 2.333 0 0
Basigin interactions R-HSA-210991 4.669718e-03 2.331 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 4.812677e-03 2.318 0 0
Signaling by EGFR in Cancer R-HSA-1643713 4.945990e-03 2.306 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 4.945990e-03 2.306 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 4.955005e-03 2.305 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 4.955005e-03 2.305 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 5.100963e-03 2.292 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 5.201836e-03 2.284 0 0
MHC class II antigen presentation R-HSA-2132295 5.515257e-03 2.258 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 5.648531e-03 2.248 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 5.792928e-03 2.237 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 5.808676e-03 2.236 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 5.808676e-03 2.236 0 0
Assembly Of The HIV Virion R-HSA-175474 5.808676e-03 2.236 0 0
PCP/CE pathway R-HSA-4086400 5.898573e-03 2.229 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.952949e-03 2.225 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.952949e-03 2.225 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.995106e-03 2.222 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 5.995106e-03 2.222 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 6.056547e-03 2.218 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 6.141802e-03 2.212 0 0
Stabilization of p53 R-HSA-69541 6.607855e-03 2.180 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 6.634080e-03 2.178 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 6.986084e-03 2.156 0 0
Vpu mediated degradation of CD4 R-HSA-180534 6.988762e-03 2.156 0 0
GP1b-IX-V activation signalling R-HSA-430116 7.074489e-03 2.150 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.147466e-03 2.146 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 7.466850e-03 2.127 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 7.682805e-03 2.114 0 0
Regulation of TNFR1 signaling R-HSA-5357905 8.126966e-03 2.090 0 0
Metabolism of proteins R-HSA-392499 8.145981e-03 2.089 0 0
Mitophagy R-HSA-5205647 8.215985e-03 2.085 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.215985e-03 2.085 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.215985e-03 2.085 0 0
Synthesis of DNA R-HSA-69239 8.324251e-03 2.080 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 8.340357e-03 2.079 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.370785e-03 2.077 0 0
Maturation of protein E R-HSA-9694493 8.421571e-03 2.075 0 0
Maturation of protein E R-HSA-9683683 8.421571e-03 2.075 0 0
Syndecan interactions R-HSA-3000170 8.706651e-03 2.060 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 8.889086e-03 2.051 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.889086e-03 2.051 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.291487e-03 2.032 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 9.369762e-03 2.028 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 9.756890e-03 2.011 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 9.756890e-03 2.011 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.195751e-02 1.922 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.195751e-02 1.922 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.195751e-02 1.922 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.034916e-02 1.985 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.050693e-02 1.979 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.018601e-02 1.992 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.018601e-02 1.992 0 0
TNF signaling R-HSA-75893 1.204743e-02 1.919 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 9.602420e-03 2.018 0 0
Degradation of CRY and PER proteins R-HSA-9932298 1.023675e-02 1.990 0 0
Budding and maturation of HIV virion R-HSA-162588 1.198317e-02 1.921 0 0
Signal transduction by L1 R-HSA-445144 1.268856e-02 1.897 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.198317e-02 1.921 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.602420e-03 2.018 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.602420e-03 2.018 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.023675e-02 1.990 0 0
Ion homeostasis R-HSA-5578775 1.204743e-02 1.919 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 1.116055e-02 1.952 0 0
ER-Phagosome pathway R-HSA-1236974 9.548431e-03 2.020 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 9.923177e-03 2.003 0 0
Immune System R-HSA-168256 1.243113e-02 1.905 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.290294e-02 1.889 0 0
Degradation of AXIN R-HSA-4641257 1.290294e-02 1.889 0 0
PTEN Regulation R-HSA-6807070 1.316301e-02 1.881 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 1.339700e-02 1.873 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.341895e-02 1.872 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.357335e-02 1.867 0 0
MAPK family signaling cascades R-HSA-5683057 1.407084e-02 1.852 0 0
Negative regulation of FLT3 R-HSA-9706369 1.501094e-02 1.824 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.529182e-02 1.816 0 0
Hedgehog ligand biogenesis R-HSA-5358346 1.529182e-02 1.816 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.627227e-02 1.789 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.627227e-02 1.789 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.627227e-02 1.789 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.656645e-02 1.781 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 1.682345e-02 1.774 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.682345e-02 1.774 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 1.699050e-02 1.770 0 0
Activation of RAC1 R-HSA-428540 1.705934e-02 1.768 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 1.705934e-02 1.768 0 0
mRNA 3'-end processing R-HSA-72187 1.717015e-02 1.765 0 0
Potential therapeutics for SARS R-HSA-9679191 1.720004e-02 1.764 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 1.724543e-02 1.763 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 1.724543e-02 1.763 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.724543e-02 1.763 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.724543e-02 1.763 0 0
Signaling by NOTCH4 R-HSA-9013694 1.742785e-02 1.759 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 1.755893e-02 1.756 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.755893e-02 1.756 0 0
Adaptive Immune System R-HSA-1280218 1.846036e-02 1.734 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 1.856678e-02 1.731 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.879507e-02 1.726 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.052593e-02 1.688 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 2.052593e-02 1.688 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.080194e-02 1.682 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 2.158996e-02 1.666 0 0
Dual Incision in GG-NER R-HSA-5696400 2.158996e-02 1.666 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.178785e-02 1.662 0 0
VLDLR internalisation and degradation R-HSA-8866427 2.178785e-02 1.662 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 2.178785e-02 1.662 0 0
IRAK1 recruits IKK complex R-HSA-937039 2.178785e-02 1.662 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.178785e-02 1.662 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.184638e-02 1.661 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.186306e-02 1.660 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 2.195759e-02 1.658 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.196360e-02 1.658 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 2.196360e-02 1.658 0 0
Death Receptor Signaling R-HSA-73887 2.216166e-02 1.654 0 0
Signaling by Hippo R-HSA-2028269 2.265873e-02 1.645 0 0
Unfolded Protein Response (UPR) R-HSA-381119 2.271051e-02 1.644 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.383223e-02 1.623 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 2.383223e-02 1.623 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.383223e-02 1.623 0 0
Formation of annular gap junctions R-HSA-196025 2.400003e-02 1.620 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 2.400003e-02 1.620 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.400003e-02 1.620 0 0
Modulation by Mtb of host immune system R-HSA-9637628 2.400003e-02 1.620 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.400026e-02 1.620 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 2.422862e-02 1.616 0 0
Gluconeogenesis R-HSA-70263 2.448493e-02 1.611 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.467122e-02 1.608 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.514481e-02 1.600 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 2.656193e-02 1.576 0 0
Hedgehog 'on' state R-HSA-5632684 2.656193e-02 1.576 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.729429e-02 1.564 0 0
GAB1 signalosome R-HSA-180292 2.731692e-02 1.564 0 0
DNA Damage Bypass R-HSA-73893 2.732810e-02 1.563 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.732810e-02 1.563 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.732810e-02 1.563 0 0
Signaling by FGFR2 R-HSA-5654738 2.984538e-02 1.525 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.021045e-02 1.520 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.025467e-02 1.519 0 0
Cellular response to hypoxia R-HSA-1234174 3.068673e-02 1.513 0 0
Signaling by FGFR4 R-HSA-5654743 3.128741e-02 1.505 0 0
EGFR downregulation R-HSA-182971 3.153021e-02 1.501 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 3.153021e-02 1.501 0 0
Gap junction degradation R-HSA-190873 3.153745e-02 1.501 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 3.153745e-02 1.501 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.153745e-02 1.501 0 0
Signaling by TGFB family members R-HSA-9006936 3.161343e-02 1.500 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 3.171988e-02 1.499 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 3.174635e-02 1.498 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.190258e-02 1.496 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 3.231889e-02 1.491 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 3.231889e-02 1.491 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.551237e-02 1.450 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 4.496150e-02 1.347 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 4.496150e-02 1.347 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 3.361307e-02 1.473 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 4.076989e-02 1.390 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 4.878165e-02 1.312 0 0
Integrin signaling R-HSA-354192 4.077456e-02 1.390 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 4.481821e-02 1.349 0 0
Signaling by ERBB4 R-HSA-1236394 3.455580e-02 1.461 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 3.576489e-02 1.447 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 3.922860e-02 1.406 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 3.922860e-02 1.406 0 0
Translesion Synthesis by POLH R-HSA-110320 3.256759e-02 1.487 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 4.077456e-02 1.390 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 3.922860e-02 1.406 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 3.361307e-02 1.473 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 3.727352e-02 1.429 0 0
PIP3 activates AKT signaling R-HSA-1257604 4.392533e-02 1.357 0 0
Long-term potentiation R-HSA-9620244 3.510118e-02 1.455 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.551237e-02 1.450 0 0
DCC mediated attractive signaling R-HSA-418885 4.076989e-02 1.390 0 0
Negative regulation of MET activity R-HSA-6807004 3.843274e-02 1.415 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 3.371402e-02 1.472 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 3.256759e-02 1.487 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 4.076989e-02 1.390 0 0
Signaling by FGFR3 R-HSA-5654741 3.886934e-02 1.410 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 4.496150e-02 1.347 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.811747e-02 1.419 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 4.594524e-02 1.338 0 0
NRIF signals cell death from the nucleus R-HSA-205043 3.361307e-02 1.473 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 4.734165e-02 1.325 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 3.361307e-02 1.473 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 4.261358e-02 1.370 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 4.878165e-02 1.312 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 4.110997e-02 1.386 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.440605e-02 1.463 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.700979e-02 1.432 0 0
G1/S Transition R-HSA-69206 3.922860e-02 1.406 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 4.031511e-02 1.395 0 0
Disease R-HSA-1643685 3.770642e-02 1.424 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.886934e-02 1.410 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.734165e-02 1.325 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 3.493533e-02 1.457 0 0
Inositol phosphate metabolism R-HSA-1483249 4.039003e-02 1.394 0 0
p75NTR signals via NF-kB R-HSA-193639 4.076989e-02 1.390 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 3.886934e-02 1.410 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 4.496150e-02 1.347 0 0
IRE1alpha activates chaperones R-HSA-381070 4.433150e-02 1.353 0 0
Pexophagy R-HSA-9664873 4.031511e-02 1.395 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 4.987140e-02 1.302 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 4.987140e-02 1.302 0 0
Clathrin-mediated endocytosis R-HSA-8856828 5.016974e-02 1.300 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 5.034238e-02 1.298 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 5.034238e-02 1.298 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 5.067701e-02 1.295 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.067701e-02 1.295 0 0
XBP1(S) activates chaperone genes R-HSA-381038 5.139406e-02 1.289 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 5.148922e-02 1.288 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 5.166269e-02 1.287 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 5.166269e-02 1.287 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 5.207197e-02 1.283 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 5.207197e-02 1.283 0 0
Vesicle-mediated transport R-HSA-5653656 5.353047e-02 1.271 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.412579e-02 1.267 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 5.412579e-02 1.267 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 5.412579e-02 1.267 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 5.548569e-02 1.256 0 0
Signaling by MET R-HSA-6806834 5.548826e-02 1.256 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 5.732349e-02 1.242 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 5.765655e-02 1.239 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 5.765655e-02 1.239 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 5.765655e-02 1.239 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 5.765655e-02 1.239 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 5.926214e-02 1.227 0 0
mRNA Editing: A to I Conversion R-HSA-75064 5.926214e-02 1.227 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 5.926214e-02 1.227 0 0
C6 deamination of adenosine R-HSA-75102 5.926214e-02 1.227 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 5.926214e-02 1.227 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 5.926214e-02 1.227 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 5.926214e-02 1.227 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 5.926214e-02 1.227 0 0
Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) R-HSA-1299308 5.926214e-02 1.227 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 5.926214e-02 1.227 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 5.926214e-02 1.227 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 5.926214e-02 1.227 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 5.926214e-02 1.227 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 5.926214e-02 1.227 0 0
Termination of translesion DNA synthesis R-HSA-5656169 5.948876e-02 1.226 0 0
Nef and signal transduction R-HSA-164944 5.968719e-02 1.224 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 5.986727e-02 1.223 0 0
mTORC1-mediated signalling R-HSA-166208 5.986727e-02 1.223 0 0
Integration of provirus R-HSA-162592 6.160987e-02 1.210 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 6.160987e-02 1.210 0 0
NF-kB is activated and signals survival R-HSA-209560 6.160987e-02 1.210 0 0
Circadian clock R-HSA-9909396 6.236818e-02 1.205 0 0
Regulation of TP53 Degradation R-HSA-6804757 6.426431e-02 1.192 0 0
Response of endothelial cells to shear stress R-HSA-9860931 6.513214e-02 1.186 0 0
Response of Mtb to phagocytosis R-HSA-9637690 6.722179e-02 1.172 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 6.739439e-02 1.171 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 6.739439e-02 1.171 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.739439e-02 1.171 0 0
Downstream TCR signaling R-HSA-202424 6.766234e-02 1.170 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 7.190348e-02 1.143 0 0
MITF-M-dependent gene expression R-HSA-9856651 7.204442e-02 1.142 0 0
EPHB-mediated forward signaling R-HSA-3928662 7.375139e-02 1.132 0 0
Proteasome assembly R-HSA-9907900 7.375139e-02 1.132 0 0
Netrin-1 signaling R-HSA-373752 7.375139e-02 1.132 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 7.409131e-02 1.130 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 7.409131e-02 1.130 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 7.409131e-02 1.130 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 7.409131e-02 1.130 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 7.519343e-02 1.124 0 0
Regulation of PTEN gene transcription R-HSA-8943724 7.542834e-02 1.122 0 0
Recycling of eIF2:GDP R-HSA-72731 7.636833e-02 1.117 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 7.636833e-02 1.117 0 0
Regulation of TP53 Activity R-HSA-5633007 7.662858e-02 1.116 0 0
Deadenylation of mRNA R-HSA-429947 7.742746e-02 1.111 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 7.798691e-02 1.108 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 7.798691e-02 1.108 0 0
Protein-protein interactions at synapses R-HSA-6794362 7.850665e-02 1.105 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 7.992628e-02 1.097 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 8.065856e-02 1.093 0 0
Somitogenesis R-HSA-9824272 8.065856e-02 1.093 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.147763e-02 1.089 0 0
G alpha (12/13) signalling events R-HSA-416482 8.541738e-02 1.068 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 8.645814e-02 1.063 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 8.645814e-02 1.063 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.645814e-02 1.063 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 8.681165e-02 1.061 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 8.696777e-02 1.061 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 8.696777e-02 1.061 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 8.696777e-02 1.061 0 0
MET activates PTPN11 R-HSA-8865999 8.696777e-02 1.061 0 0
Tight junction interactions R-HSA-420029 8.718601e-02 1.060 0 0
HDMs demethylate histones R-HSA-3214842 8.718601e-02 1.060 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 8.774566e-02 1.057 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 8.774566e-02 1.057 0 0
Regulation of pyruvate metabolism R-HSA-9861718 8.794393e-02 1.056 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 8.921803e-02 1.050 0 0
Regulation of signaling by CBL R-HSA-912631 8.941837e-02 1.049 0 0
Rap1 signalling R-HSA-392517 8.941837e-02 1.049 0 0
Hemostasis R-HSA-109582 8.995286e-02 1.046 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 9.223374e-02 1.035 0 0
Defective SFTPA2 causes IPF R-HSA-5687868 9.323595e-02 1.030 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 9.323595e-02 1.030 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 9.484847e-02 1.023 0 0
Adrenoceptors R-HSA-390696 9.484847e-02 1.023 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 9.758542e-02 1.011 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.758542e-02 1.011 0 0
Developmental Cell Lineages R-HSA-9734767 9.918795e-02 1.004 0 0
Ion transport by P-type ATPases R-HSA-936837 1.013851e-01 0.994 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 1.016661e-01 0.993 0 0
Glycogen synthesis R-HSA-3322077 1.016661e-01 0.993 0 0
Signal regulatory protein family interactions R-HSA-391160 1.025192e-01 0.989 0 0
Signaling by FGFR1 R-HSA-5654736 1.028449e-01 0.988 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.034500e-01 0.985 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 1.049652e-01 0.979 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.086120e-01 0.964 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 1.086120e-01 0.964 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 1.096457e-01 0.960 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.117324e-01 0.952 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.147011e-01 0.940 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.147011e-01 0.940 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 1.147011e-01 0.940 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 1.147011e-01 0.940 0 0
Gene expression (Transcription) R-HSA-74160 1.149464e-01 0.940 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 1.149521e-01 0.939 0 0
WNT mediated activation of DVL R-HSA-201688 1.149521e-01 0.939 0 0
ALK mutants bind TKIs R-HSA-9700645 1.149521e-01 0.939 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.149521e-01 0.939 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.149521e-01 0.939 0 0
Unwinding of DNA R-HSA-176974 1.149521e-01 0.939 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.149521e-01 0.939 0 0
Regulation of gap junction activity R-HSA-191650 1.176861e-01 0.929 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.176861e-01 0.929 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.176861e-01 0.929 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.176861e-01 0.929 0 0
TNFR1-mediated ceramide production R-HSA-5626978 1.176861e-01 0.929 0 0
MTF1 activates gene expression R-HSA-5660489 1.176861e-01 0.929 0 0
Translesion synthesis by REV1 R-HSA-110312 1.183476e-01 0.927 0 0
Protein methylation R-HSA-8876725 1.183476e-01 0.927 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.183476e-01 0.927 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.777839e-01 0.750 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.777839e-01 0.750 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.777839e-01 0.750 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.777839e-01 0.750 0 0
Hereditary fructose intolerance R-HSA-5657560 1.777839e-01 0.750 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.777839e-01 0.750 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.777839e-01 0.750 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 1.777839e-01 0.750 0 0
SARS-CoV-1 targets PDZ proteins in cell-cell junction R-HSA-9692912 1.777839e-01 0.750 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 1.777839e-01 0.750 0 0
Defective F8 binding to von Willebrand factor R-HSA-9672393 1.777839e-01 0.750 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.777839e-01 0.750 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.777839e-01 0.750 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.777839e-01 0.750 0 0
Defective ACTH causes obesity and POMCD R-HSA-5579031 1.777839e-01 0.750 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.506153e-01 0.822 0 0
Co-inhibition by BTLA R-HSA-9927353 1.506153e-01 0.822 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.506153e-01 0.822 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.506153e-01 0.822 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 1.506153e-01 0.822 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 1.506153e-01 0.822 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 1.850767e-01 0.733 0 0
Pentose phosphate pathway disease R-HSA-6791465 1.850767e-01 0.733 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.850767e-01 0.733 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 1.850767e-01 0.733 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 1.850767e-01 0.733 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 1.364923e-01 0.865 0 0
2-LTR circle formation R-HSA-164843 1.364923e-01 0.865 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.204988e-01 0.657 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.204988e-01 0.657 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 2.204988e-01 0.657 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 2.204988e-01 0.657 1 1
Autointegration results in viral DNA circles R-HSA-177539 2.204988e-01 0.657 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 2.204988e-01 0.657 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 1.351580e-01 0.869 0 0
Translesion synthesis by POLI R-HSA-5656121 1.351580e-01 0.869 0 0
Phosphorylation of the APC/C R-HSA-176412 1.351580e-01 0.869 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 1.831151e-01 0.737 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 1.831151e-01 0.737 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 1.831151e-01 0.737 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.831151e-01 0.737 0 0
Disorders of Developmental Biology R-HSA-9675151 1.528707e-01 0.816 0 0
Translesion synthesis by POLK R-HSA-5655862 1.528707e-01 0.816 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.078176e-01 0.682 0 0
Disorders of Nervous System Development R-HSA-9697154 2.078176e-01 0.682 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.078176e-01 0.682 0 0
Pervasive developmental disorders R-HSA-9005895 2.078176e-01 0.682 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.078176e-01 0.682 0 0
Scavenging by Class F Receptors R-HSA-3000484 2.078176e-01 0.682 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.078176e-01 0.682 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.078176e-01 0.682 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.078176e-01 0.682 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.078176e-01 0.682 0 0
FGFR2 alternative splicing R-HSA-6803529 1.429897e-01 0.845 0 0
HIV elongation arrest and recovery R-HSA-167287 1.202483e-01 0.920 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.202483e-01 0.920 0 0
Formation of axial mesoderm R-HSA-9796292 2.332033e-01 0.632 0 0
Activation of the pre-replicative complex R-HSA-68962 1.452631e-01 0.838 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 2.310128e-01 0.636 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.724259e-01 0.763 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.245559e-01 0.649 0 0
Cristae formation R-HSA-8949613 2.245559e-01 0.649 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.245559e-01 0.649 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 2.014926e-01 0.696 0 0
Dual incision in TC-NER R-HSA-6782135 2.032551e-01 0.692 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.383365e-01 0.623 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.273204e-01 0.643 0 0
Post-translational protein phosphorylation R-HSA-8957275 1.882333e-01 0.725 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.880716e-01 0.726 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.204615e-01 0.919 0 0
Interferon alpha/beta signaling R-HSA-909733 2.034453e-01 0.692 0 0
MET promotes cell motility R-HSA-8875878 1.565916e-01 0.805 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 1.506153e-01 0.822 0 0
Regulation of CDH11 function R-HSA-9762292 1.364923e-01 0.865 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 1.351580e-01 0.869 0 0
Generation of second messenger molecules R-HSA-202433 1.816853e-01 0.741 0 0
CREB phosphorylation R-HSA-199920 2.204988e-01 0.657 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.528707e-01 0.816 0 0
Myogenesis R-HSA-525793 2.072038e-01 0.684 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 1.644460e-01 0.784 0 0
MyD88-independent TLR4 cascade R-HSA-166166 2.218826e-01 0.654 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 2.218826e-01 0.654 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 1.850767e-01 0.733 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 1.714012e-01 0.766 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.903183e-01 0.721 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.221690e-01 0.653 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 2.347686e-01 0.629 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 2.332033e-01 0.632 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.332033e-01 0.632 0 0
Post-translational protein modification R-HSA-597592 2.021585e-01 0.694 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 1.585904e-01 0.800 0 0
Pentose phosphate pathway R-HSA-71336 1.689332e-01 0.772 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 1.506153e-01 0.822 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.324734e-01 0.878 0 0
MAP kinase activation R-HSA-450294 2.389876e-01 0.622 0 0
Regulated Necrosis R-HSA-5218859 2.161368e-01 0.665 0 0
Neurexins and neuroligins R-HSA-6794361 1.394583e-01 0.856 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 1.678151e-01 0.775 0 0
Pyruvate metabolism R-HSA-70268 1.542301e-01 0.812 0 0
Signaling by FGFR R-HSA-190236 1.221529e-01 0.913 0 0
Inhibition of PKR R-HSA-169131 1.777839e-01 0.750 0 0
Proton/oligopeptide cotransporters R-HSA-427975 1.850767e-01 0.733 0 0
Mitochondrial calcium ion transport R-HSA-8949215 1.284888e-01 0.891 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 1.714012e-01 0.766 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 2.332033e-01 0.632 0 0
Platelet calcium homeostasis R-HSA-418360 1.324734e-01 0.878 0 0
NOD1/2 Signaling Pathway R-HSA-168638 2.166552e-01 0.664 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.867378e-01 0.729 0 0
Formation of paraxial mesoderm R-HSA-9793380 1.449145e-01 0.839 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 2.221690e-01 0.653 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 1.807612e-01 0.743 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 1.528707e-01 0.816 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 2.162588e-01 0.665 0 0
DAG and IP3 signaling R-HSA-1489509 1.532959e-01 0.814 0 0
Iron uptake and transport R-HSA-917937 1.960328e-01 0.708 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 1.867378e-01 0.729 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.724259e-01 0.763 0 0
Protein hydroxylation R-HSA-9629569 2.310128e-01 0.636 0 0
Neuronal System R-HSA-112316 1.319874e-01 0.879 0 0
FLT3 signaling in disease R-HSA-9682385 1.332240e-01 0.875 0 0
Transmission across Chemical Synapses R-HSA-112315 1.926880e-01 0.715 0 0
PERK regulates gene expression R-HSA-381042 2.321894e-01 0.634 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.429897e-01 0.845 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.221600e-01 0.913 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 1.506153e-01 0.822 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.204988e-01 0.657 0 0
Maturation of nucleoprotein R-HSA-9683610 2.332033e-01 0.632 0 0
CD28 dependent Vav1 pathway R-HSA-389359 2.332033e-01 0.632 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 1.724259e-01 0.763 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.867378e-01 0.729 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.364923e-01 0.865 0 0
Sensory processing of sound R-HSA-9659379 1.520162e-01 0.818 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 1.394583e-01 0.856 0 0
Maturation of nucleoprotein R-HSA-9694631 2.105623e-01 0.677 0 0
Oncogene Induced Senescence R-HSA-2559585 1.222356e-01 0.913 0 0
Insulin processing R-HSA-264876 2.245559e-01 0.649 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.083280e-01 0.681 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 2.245559e-01 0.649 0 0
ABC-family proteins mediated transport R-HSA-382556 2.055674e-01 0.687 0 0
FLT3 Signaling R-HSA-9607240 1.948250e-01 0.710 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 1.846375e-01 0.734 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 1.528707e-01 0.816 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 2.310128e-01 0.636 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.906616e-01 0.720 0 0
Suppression of phagosomal maturation R-HSA-9637687 2.072038e-01 0.684 0 0
ABC transporter disorders R-HSA-5619084 2.270624e-01 0.644 0 0
Regulation of BACH1 activity R-HSA-9708530 1.351580e-01 0.869 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 2.105623e-01 0.677 0 0
Translation of Structural Proteins R-HSA-9683701 2.083280e-01 0.681 0 0
Glycogen storage diseases R-HSA-3229121 1.714012e-01 0.766 0 0
Interleukin-37 signaling R-HSA-9008059 1.452631e-01 0.838 0 0
Disorders of transmembrane transporters R-HSA-5619115 2.474795e-01 0.606 0 0
Calmodulin induced events R-HSA-111933 2.480581e-01 0.605 0 0
CaM pathway R-HSA-111997 2.480581e-01 0.605 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.487550e-01 0.604 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.516415e-01 0.599 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 2.519235e-01 0.599 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 2.544531e-01 0.594 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.544531e-01 0.594 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.544531e-01 0.594 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 2.544531e-01 0.594 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 2.544531e-01 0.594 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.544531e-01 0.594 0 0
Defective VWF binding to collagen type I R-HSA-9845622 2.544531e-01 0.594 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 2.544531e-01 0.594 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 2.544531e-01 0.594 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 2.544531e-01 0.594 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 2.544531e-01 0.594 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.544531e-01 0.594 0 0
IKBKB deficiency causes SCID R-HSA-5602636 2.544531e-01 0.594 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.544531e-01 0.594 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.544531e-01 0.594 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.544531e-01 0.594 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.544531e-01 0.594 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.564033e-01 0.591 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 2.564033e-01 0.591 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 2.564033e-01 0.591 0 0
TRIF-mediated programmed cell death R-HSA-2562578 2.564033e-01 0.591 0 0
Disinhibition of SNARE formation R-HSA-114516 2.564033e-01 0.591 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 2.564033e-01 0.591 0 0
Netrin mediated repulsion signals R-HSA-418886 2.564033e-01 0.591 0 0
CHL1 interactions R-HSA-447041 2.564033e-01 0.591 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 2.564033e-01 0.591 0 0
SLC-mediated transport of oligopeptides R-HSA-9959399 2.564033e-01 0.591 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 2.564033e-01 0.591 0 0
Regulation of KIT signaling R-HSA-1433559 2.590997e-01 0.587 0 0
Malate-aspartate shuttle R-HSA-9856872 2.590997e-01 0.587 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 2.604410e-01 0.584 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.614865e-01 0.583 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.621166e-01 0.582 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.732061e-01 0.564 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.732061e-01 0.564 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 2.732061e-01 0.564 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.776294e-01 0.557 0 0
Cardiac conduction R-HSA-5576891 2.777683e-01 0.556 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.788639e-01 0.555 0 0
G alpha (z) signalling events R-HSA-418597 2.789148e-01 0.555 0 0
Signaling by NOTCH3 R-HSA-9012852 2.789148e-01 0.555 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.803757e-01 0.552 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 2.803757e-01 0.552 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 2.825804e-01 0.549 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.853446e-01 0.545 0 0
G beta:gamma signalling through BTK R-HSA-8964315 2.853446e-01 0.545 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.853446e-01 0.545 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 2.853446e-01 0.545 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.853446e-01 0.545 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.853446e-01 0.545 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.853446e-01 0.545 0 0
Type I hemidesmosome assembly R-HSA-446107 2.923926e-01 0.534 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 2.923926e-01 0.534 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 2.923926e-01 0.534 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 2.923926e-01 0.534 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 2.923926e-01 0.534 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 2.923926e-01 0.534 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 2.923926e-01 0.534 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 2.923926e-01 0.534 0 0
NRAGE signals death through JNK R-HSA-193648 2.928395e-01 0.533 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 2.954992e-01 0.529 0 0
Plasma lipoprotein clearance R-HSA-8964043 2.972925e-01 0.527 0 0
RAS processing R-HSA-9648002 2.972925e-01 0.527 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 2.972925e-01 0.527 0 0
Trafficking of AMPA receptors R-HSA-399719 2.975343e-01 0.526 0 0
Downstream signal transduction R-HSA-186763 2.975343e-01 0.526 0 0
Molecules associated with elastic fibres R-HSA-2129379 2.975343e-01 0.526 0 0
Ion channel transport R-HSA-983712 3.064544e-01 0.514 0 0
Interleukin-1 signaling R-HSA-9020702 3.066944e-01 0.513 0 0
Activation of SMO R-HSA-5635838 3.117874e-01 0.506 0 0
Killing mechanisms R-HSA-9664420 3.117874e-01 0.506 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 3.117874e-01 0.506 0 0
Interleukin-1 family signaling R-HSA-446652 3.118628e-01 0.506 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 3.141201e-01 0.503 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.160146e-01 0.500 0 0
Protein localization R-HSA-9609507 3.206110e-01 0.494 0 0
Translation of Structural Proteins R-HSA-9694635 3.234223e-01 0.490 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.239772e-01 0.489 0 0
Defective ALG9 causes CDG-1l R-HSA-4720454 3.239772e-01 0.489 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 3.239772e-01 0.489 0 0
Defective F8 cleavage by thrombin R-HSA-9672391 3.239772e-01 0.489 0 0
Defective AHCY causes HMAHCHD R-HSA-5578997 3.239772e-01 0.489 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 3.239772e-01 0.489 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.239772e-01 0.489 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.239772e-01 0.489 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 3.239772e-01 0.489 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 3.239772e-01 0.489 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 3.239772e-01 0.489 0 0
Potassium transport channels R-HSA-1296067 3.239772e-01 0.489 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.239772e-01 0.489 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.239772e-01 0.489 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 3.239772e-01 0.489 0 0
Lipophagy R-HSA-9613354 3.281389e-01 0.484 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 3.281389e-01 0.484 0 0
mRNA Editing R-HSA-75072 3.281389e-01 0.484 0 0
Calcineurin activates NFAT R-HSA-2025928 3.281389e-01 0.484 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.281389e-01 0.484 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.281389e-01 0.484 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.281389e-01 0.484 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.281389e-01 0.484 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 3.281389e-01 0.484 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 3.310932e-01 0.480 0 0
Nuclear RNA decay R-HSA-9930044 3.354047e-01 0.474 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.354047e-01 0.474 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.355014e-01 0.474 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 3.382893e-01 0.471 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 3.382893e-01 0.471 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 3.384415e-01 0.471 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.384415e-01 0.471 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 3.495134e-01 0.457 0 0
Interleukin-17 signaling R-HSA-448424 3.563663e-01 0.448 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 3.565805e-01 0.448 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 3.565805e-01 0.448 0 0
The phototransduction cascade R-HSA-2514856 3.574347e-01 0.447 0 0
Binding and entry of HIV virion R-HSA-173107 3.633749e-01 0.440 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 3.633749e-01 0.440 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 3.633749e-01 0.440 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 3.633749e-01 0.440 0 0
Receptor Mediated Mitophagy R-HSA-8934903 3.633749e-01 0.440 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.633749e-01 0.440 0 0
Signaling by Leptin R-HSA-2586552 3.633749e-01 0.440 0 0
Tandem pore domain potassium channels R-HSA-1296346 3.633749e-01 0.440 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 3.642535e-01 0.439 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 3.647241e-01 0.438 0 0
MTOR signalling R-HSA-165159 3.653297e-01 0.437 0 0
Ca-dependent events R-HSA-111996 3.653297e-01 0.437 0 0
Signaling by NOTCH2 R-HSA-1980145 3.736411e-01 0.428 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 3.736411e-01 0.428 0 0
Calnexin/calreticulin cycle R-HSA-901042 3.736411e-01 0.428 0 0
Mitochondrial protein import R-HSA-1268020 3.790327e-01 0.421 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 3.823069e-01 0.418 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 3.823069e-01 0.418 0 0
PLC-gamma1 signalling R-HSA-167021 3.870217e-01 0.412 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 3.870217e-01 0.412 0 0
Axonal growth stimulation R-HSA-209563 3.870217e-01 0.412 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 3.870217e-01 0.412 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 3.870217e-01 0.412 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 3.870217e-01 0.412 0 0
MET interacts with TNS proteins R-HSA-8875513 3.870217e-01 0.412 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 3.870217e-01 0.412 0 0
Intracellular oxygen transport R-HSA-8981607 3.870217e-01 0.412 0 0
FasL/ CD95L signaling R-HSA-75157 3.870217e-01 0.412 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 3.888802e-01 0.410 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 3.909778e-01 0.408 0 0
Synaptic adhesion-like molecules R-HSA-8849932 3.909778e-01 0.408 0 0
Polo-like kinase mediated events R-HSA-156711 3.909778e-01 0.408 0 0
Platelet sensitization by LDL R-HSA-432142 3.909778e-01 0.408 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 3.909778e-01 0.408 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 3.978850e-01 0.400 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 3.978850e-01 0.400 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 3.978850e-01 0.400 0 0
Formation of the posterior neural plate R-HSA-9832991 3.978850e-01 0.400 0 0
Bicarbonate transporters R-HSA-425381 3.978850e-01 0.400 0 0
Signaling by APC mutants R-HSA-4839744 3.978850e-01 0.400 0 0
Suppression of apoptosis R-HSA-9635465 3.978850e-01 0.400 0 0
Cyclin D associated events in G1 R-HSA-69231 3.997188e-01 0.398 0 0
G1 Phase R-HSA-69236 3.997188e-01 0.398 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 4.023483e-01 0.395 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.082502e-01 0.389 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 4.118615e-01 0.385 0 0
G1/S-Specific Transcription R-HSA-69205 4.118615e-01 0.385 0 0
Fanconi Anemia Pathway R-HSA-6783310 4.168869e-01 0.380 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.169485e-01 0.380 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 4.179955e-01 0.379 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.287990e-01 0.368 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 4.314983e-01 0.365 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.314983e-01 0.365 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 4.314983e-01 0.365 0 0
Signaling by AXIN mutants R-HSA-4839735 4.314983e-01 0.365 0 0
Signaling by AMER1 mutants R-HSA-4839748 4.314983e-01 0.365 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 4.314983e-01 0.365 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 4.425462e-01 0.354 0 0
Co-inhibition by CTLA4 R-HSA-389513 4.425462e-01 0.354 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 4.425462e-01 0.354 0 0
Formation of definitive endoderm R-HSA-9823730 4.425462e-01 0.354 0 0
Metabolism of amino acids and derivatives R-HSA-71291 4.429486e-01 0.354 0 0
HCN channels R-HSA-1296061 4.441902e-01 0.352 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 4.441902e-01 0.352 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.441902e-01 0.352 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.441902e-01 0.352 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.441902e-01 0.352 0 0
Extrinsic Pathway of Fibrin Clot Formation R-HSA-140834 4.441902e-01 0.352 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 4.441902e-01 0.352 0 0
Dopamine receptors R-HSA-390651 4.441902e-01 0.352 0 0
NADE modulates death signalling R-HSA-205025 4.441902e-01 0.352 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 4.441902e-01 0.352 0 0
Toxicity of tetanus toxin (tetX) R-HSA-5250982 4.441902e-01 0.352 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 4.472988e-01 0.349 0 0
SLC transporter disorders R-HSA-5619102 4.477264e-01 0.349 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 4.497198e-01 0.347 0 0
Elastic fibre formation R-HSA-1566948 4.497198e-01 0.347 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 4.499048e-01 0.347 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 4.508512e-01 0.346 0 0
Opioid Signalling R-HSA-111885 4.512589e-01 0.346 0 0
G-protein mediated events R-HSA-112040 4.519651e-01 0.345 0 0
Signaling by NTRKs R-HSA-166520 4.585967e-01 0.339 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.640821e-01 0.333 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 4.640821e-01 0.333 0 0
Regulation of IFNG signaling R-HSA-877312 4.640821e-01 0.333 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 4.640821e-01 0.333 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 4.640821e-01 0.333 0 0
Integrin cell surface interactions R-HSA-216083 4.655841e-01 0.332 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 4.676921e-01 0.330 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 4.676921e-01 0.330 0 0
G-protein activation R-HSA-202040 4.676921e-01 0.330 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 4.676921e-01 0.330 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 4.676921e-01 0.330 0 0
GPER1 signaling R-HSA-9634597 4.679172e-01 0.330 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 4.679172e-01 0.330 0 0
Co-stimulation by CD28 R-HSA-389356 4.679172e-01 0.330 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 4.684157e-01 0.329 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 4.719273e-01 0.326 0 0
Peroxisomal protein import R-HSA-9033241 4.826597e-01 0.316 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 4.843579e-01 0.315 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 4.843579e-01 0.315 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 4.846755e-01 0.315 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 4.846755e-01 0.315 0 0
HIV Transcription Elongation R-HSA-167169 4.869094e-01 0.313 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.869094e-01 0.313 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 4.869094e-01 0.313 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 4.869094e-01 0.313 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 4.869094e-01 0.313 0 0
Diseases of Immune System R-HSA-5260271 4.869094e-01 0.313 0 0
Glycogen metabolism R-HSA-8982491 4.869094e-01 0.313 0 0
Toll-like Receptor Cascades R-HSA-168898 4.902026e-01 0.310 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 4.923180e-01 0.308 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 4.923180e-01 0.308 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 4.923180e-01 0.308 0 0
Ribavirin ADME R-HSA-9755088 4.923180e-01 0.308 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.955359e-01 0.305 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 4.955359e-01 0.305 0 0
Interleukin-6 signaling R-HSA-1059683 4.955359e-01 0.305 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 4.955359e-01 0.305 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 4.960301e-01 0.304 0 0
IRS activation R-HSA-74713 4.960301e-01 0.304 0 0
Defective F9 activation R-HSA-9673221 4.960301e-01 0.304 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 4.960301e-01 0.304 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 4.960301e-01 0.304 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 4.960301e-01 0.304 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 4.960301e-01 0.304 0 0
NTRK2 activates RAC1 R-HSA-9032759 4.960301e-01 0.304 0 0
Suppression of autophagy R-HSA-9636569 4.960301e-01 0.304 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 4.960301e-01 0.304 0 0
Muscarinic acetylcholine receptors R-HSA-390648 4.960301e-01 0.304 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 4.960301e-01 0.304 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 4.979675e-01 0.303 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 4.979675e-01 0.303 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 4.979675e-01 0.303 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 4.979675e-01 0.303 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 4.979675e-01 0.303 0 0
tRNA Aminoacylation R-HSA-379724 4.979675e-01 0.303 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 5.001924e-01 0.301 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 5.001924e-01 0.301 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 5.001924e-01 0.301 0 0
Azathioprine ADME R-HSA-9748787 5.012651e-01 0.300 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 5.051692e-01 0.297 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 5.092056e-01 0.293 0 0
DNA strand elongation R-HSA-69190 5.099941e-01 0.292 0 0
PLC beta mediated events R-HSA-112043 5.131289e-01 0.290 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 5.163659e-01 0.287 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 5.163659e-01 0.287 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 5.206175e-01 0.283 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 5.233052e-01 0.281 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.257873e-01 0.279 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 5.257873e-01 0.279 0 0
Signaling by FGFR4 in disease R-HSA-5655291 5.257873e-01 0.279 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 5.257873e-01 0.279 0 0
Signaling by PDGF R-HSA-186797 5.281261e-01 0.277 0 0
G-protein beta:gamma signalling R-HSA-397795 5.301743e-01 0.276 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 5.301743e-01 0.276 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 5.338470e-01 0.273 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 5.391938e-01 0.268 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 5.391938e-01 0.268 0 0
RNA Polymerase II Transcription R-HSA-73857 5.395833e-01 0.268 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 5.397871e-01 0.268 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 5.397871e-01 0.268 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.397871e-01 0.268 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 5.403000e-01 0.267 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 5.408733e-01 0.267 0 0
Plus-strand DNA synthesis R-HSA-164525 5.430376e-01 0.265 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.430376e-01 0.265 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.430376e-01 0.265 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 5.430376e-01 0.265 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 5.430376e-01 0.265 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.430376e-01 0.265 0 0
Intestinal hexose absorption R-HSA-8981373 5.430376e-01 0.265 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 5.430376e-01 0.265 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 5.430376e-01 0.265 0 0
TRAIL signaling R-HSA-75158 5.430376e-01 0.265 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 5.430376e-01 0.265 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 5.499366e-01 0.260 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 5.499366e-01 0.260 0 0
Miscellaneous transport and binding events R-HSA-5223345 5.499366e-01 0.260 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 5.509345e-01 0.259 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 5.544233e-01 0.256 0 0
p38MAPK events R-HSA-171007 5.547869e-01 0.256 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 5.547869e-01 0.256 0 0
Formation of the anterior neural plate R-HSA-9823739 5.547869e-01 0.256 0 0
Signaling by SCF-KIT R-HSA-1433557 5.582672e-01 0.253 0 0
TBC/RABGAPs R-HSA-8854214 5.582672e-01 0.253 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 5.625417e-01 0.250 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 5.646597e-01 0.248 0 0
Gastrulation R-HSA-9758941 5.676896e-01 0.246 0 0
Signal amplification R-HSA-392518 5.692524e-01 0.245 0 0
RAF activation R-HSA-5673000 5.692524e-01 0.245 0 0
eNOS activation R-HSA-203615 5.692524e-01 0.245 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 5.692524e-01 0.245 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 5.708142e-01 0.244 0 0
Amine ligand-binding receptors R-HSA-375280 5.753264e-01 0.240 0 0
Signaling by NOTCH1 R-HSA-1980143 5.778821e-01 0.238 0 0
tRNA processing R-HSA-72306 5.779760e-01 0.238 0 0
RSV-host interactions R-HSA-9833110 5.820666e-01 0.235 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.825050e-01 0.235 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 5.825050e-01 0.235 0 0
Phase 4 - resting membrane potential R-HSA-5576886 5.825050e-01 0.235 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 5.825050e-01 0.235 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 5.825050e-01 0.235 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 5.833553e-01 0.234 0 0
TGFBR3 expression R-HSA-9839394 5.845978e-01 0.233 0 0
Laminin interactions R-HSA-3000157 5.845978e-01 0.233 0 0
Interleukin-7 signaling R-HSA-1266695 5.845978e-01 0.233 0 0
Signaling by LTK in cancer R-HSA-9842640 5.856631e-01 0.232 0 0
STAT5 Activation R-HSA-9645135 5.856631e-01 0.232 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.856631e-01 0.232 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 5.856631e-01 0.232 0 0
Uncoating of the HIV Virion R-HSA-162585 5.856631e-01 0.232 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 5.856631e-01 0.232 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 5.856631e-01 0.232 0 0
G2/M DNA replication checkpoint R-HSA-69478 5.856631e-01 0.232 0 0
Defective factor VIII causes hemophilia A R-HSA-9662001 5.856631e-01 0.232 0 0
HDL clearance R-HSA-8964011 5.856631e-01 0.232 0 0
Leukotriene receptors R-HSA-391906 5.856631e-01 0.232 0 0
VLDL assembly R-HSA-8866423 5.856631e-01 0.232 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 5.856631e-01 0.232 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 5.856631e-01 0.232 0 0
Neurofascin interactions R-HSA-447043 5.856631e-01 0.232 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 5.856631e-01 0.232 0 0
Platelet homeostasis R-HSA-418346 6.043872e-01 0.219 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 6.059306e-01 0.218 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 6.059306e-01 0.218 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 6.059306e-01 0.218 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 6.064502e-01 0.217 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 6.089285e-01 0.215 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 6.089285e-01 0.215 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.089285e-01 0.215 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 6.089285e-01 0.215 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 6.089285e-01 0.215 0 0
Response to metal ions R-HSA-5660526 6.089285e-01 0.215 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 6.109284e-01 0.214 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.243148e-01 0.205 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 6.243148e-01 0.205 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.243148e-01 0.205 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 6.243148e-01 0.205 0 0
SOS-mediated signalling R-HSA-112412 6.243148e-01 0.205 0 0
DAG1 core M1 glycosylations R-HSA-8932506 6.243148e-01 0.205 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.243148e-01 0.205 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 6.243148e-01 0.205 0 0
LDL remodeling R-HSA-8964041 6.243148e-01 0.205 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.243148e-01 0.205 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 6.243148e-01 0.205 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.243148e-01 0.205 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 6.243188e-01 0.205 0 0
Synthesis of PC R-HSA-1483191 6.243188e-01 0.205 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 6.265223e-01 0.203 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 6.265223e-01 0.203 0 0
Maturation of hRSV A proteins R-HSA-9828806 6.265223e-01 0.203 0 0
Specification of primordial germ cells R-HSA-9827857 6.340575e-01 0.198 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 6.340575e-01 0.198 0 0
NGF-stimulated transcription R-HSA-9031628 6.398736e-01 0.194 0 0
COPII-mediated vesicle transport R-HSA-204005 6.404252e-01 0.194 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 6.416169e-01 0.193 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 6.419664e-01 0.192 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 6.463607e-01 0.190 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 6.463607e-01 0.190 0 0
Metabolism of polyamines R-HSA-351202 6.535957e-01 0.185 0 0
Neddylation R-HSA-8951664 6.573247e-01 0.182 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 6.579037e-01 0.182 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.579037e-01 0.182 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 6.579037e-01 0.182 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.579037e-01 0.182 0 0
Presynaptic function of Kainate receptors R-HSA-500657 6.579037e-01 0.182 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 6.584067e-01 0.182 0 0
Reverse Transcription of HIV RNA R-HSA-162589 6.593629e-01 0.181 0 0
Minus-strand DNA synthesis R-HSA-164516 6.593629e-01 0.181 0 0
DAG1 core M2 glycosylations R-HSA-8932504 6.593629e-01 0.181 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 6.593629e-01 0.181 0 0
MET receptor recycling R-HSA-8875656 6.593629e-01 0.181 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.593629e-01 0.181 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 6.593629e-01 0.181 0 0
Regulation by c-FLIP R-HSA-3371378 6.593629e-01 0.181 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.593629e-01 0.181 0 0
Dimerization of procaspase-8 R-HSA-69416 6.593629e-01 0.181 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.593629e-01 0.181 0 0
SLC-mediated bile acid transport R-HSA-9958517 6.593629e-01 0.181 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 6.593629e-01 0.181 0 0
Intestinal absorption R-HSA-8963676 6.593629e-01 0.181 0 0
Interleukin-23 signaling R-HSA-9020933 6.593629e-01 0.181 0 0
Signaling by Erythropoietin R-HSA-9006335 6.654394e-01 0.177 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 6.654394e-01 0.177 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 6.654394e-01 0.177 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 6.729419e-01 0.172 0 0
Generic Transcription Pathway R-HSA-212436 6.748555e-01 0.171 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 6.782910e-01 0.169 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.804876e-01 0.167 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.804876e-01 0.167 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 6.804876e-01 0.167 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.804876e-01 0.167 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 6.804876e-01 0.167 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.804876e-01 0.167 0 0
The NLRP3 inflammasome R-HSA-844456 6.804876e-01 0.167 0 0
Diseases of hemostasis R-HSA-9671793 6.804876e-01 0.167 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 6.804876e-01 0.167 0 0
Extracellular matrix organization R-HSA-1474244 6.811562e-01 0.167 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 6.837564e-01 0.165 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 6.837564e-01 0.165 0 0
DAP12 signaling R-HSA-2424491 6.837564e-01 0.165 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 6.837564e-01 0.165 0 0
Activation of BH3-only proteins R-HSA-114452 6.837564e-01 0.165 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 6.903626e-01 0.161 0 0
CASP8 activity is inhibited R-HSA-5218900 6.911431e-01 0.160 0 0
p75NTR regulates axonogenesis R-HSA-193697 6.911431e-01 0.160 0 0
ARMS-mediated activation R-HSA-170984 6.911431e-01 0.160 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 6.911431e-01 0.160 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 6.911431e-01 0.160 0 0
Regulation of signaling by NODAL R-HSA-1433617 6.911431e-01 0.160 0 0
MAPK1 (ERK2) activation R-HSA-112411 6.911431e-01 0.160 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 6.911431e-01 0.160 0 0
Regulated proteolysis of p75NTR R-HSA-193692 6.911431e-01 0.160 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 6.911431e-01 0.160 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 6.911431e-01 0.160 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.979603e-01 0.156 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 7.006800e-01 0.154 0 0
Aspartate and asparagine metabolism R-HSA-8963693 7.013141e-01 0.154 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.018372e-01 0.154 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 7.018372e-01 0.154 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 7.018372e-01 0.154 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 7.018372e-01 0.154 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 7.018372e-01 0.154 0 0
Creatine metabolism R-HSA-71288 7.018372e-01 0.154 0 0
Signaling by FGFR1 in disease R-HSA-5655302 7.055221e-01 0.151 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 7.055221e-01 0.151 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.181187e-01 0.144 0 0
G0 and Early G1 R-HSA-1538133 7.181187e-01 0.144 0 0
Signaling by WNT in cancer R-HSA-4791275 7.181187e-01 0.144 0 0
PI3K/AKT activation R-HSA-198203 7.199601e-01 0.143 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.199601e-01 0.143 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.199601e-01 0.143 0 0
DNA replication initiation R-HSA-68952 7.199601e-01 0.143 0 0
Signal attenuation R-HSA-74749 7.199601e-01 0.143 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.199601e-01 0.143 0 0
MAPK3 (ERK1) activation R-HSA-110056 7.199601e-01 0.143 0 0
Peptide hormone biosynthesis R-HSA-209952 7.199601e-01 0.143 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.219862e-01 0.141 0 0
ERK/MAPK targets R-HSA-198753 7.219862e-01 0.141 0 0
Signalling to RAS R-HSA-167044 7.219862e-01 0.141 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 7.219862e-01 0.141 0 0
Innate Immune System R-HSA-168249 7.237520e-01 0.140 0 0
Rab regulation of trafficking R-HSA-9007101 7.336576e-01 0.135 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 7.341795e-01 0.134 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 7.341795e-01 0.134 0 0
Stimuli-sensing channels R-HSA-2672351 7.355184e-01 0.133 0 0
Regulation of insulin secretion R-HSA-422356 7.380591e-01 0.132 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.409727e-01 0.130 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 7.409727e-01 0.130 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 7.409727e-01 0.130 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.460900e-01 0.127 0 0
DAG1 core M3 glycosylations R-HSA-8932505 7.460900e-01 0.127 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 7.460900e-01 0.127 0 0
vRNP Assembly R-HSA-192905 7.460900e-01 0.127 0 0
Conjugation of benzoate with glycine R-HSA-177135 7.460900e-01 0.127 0 0
vRNA Synthesis R-HSA-192814 7.460900e-01 0.127 0 0
Chylomicron assembly R-HSA-8963888 7.460900e-01 0.127 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.460900e-01 0.127 0 0
Propionyl-CoA catabolism R-HSA-71032 7.460900e-01 0.127 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.460900e-01 0.127 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.460900e-01 0.127 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.460900e-01 0.127 0 0
Surfactant metabolism R-HSA-5683826 7.477353e-01 0.126 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 7.495086e-01 0.125 0 0
Effects of PIP2 hydrolysis R-HSA-114508 7.495086e-01 0.125 0 0
Transcription of the HIV genome R-HSA-167172 7.523690e-01 0.124 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 7.588382e-01 0.120 0 0
Notch-HLH transcription pathway R-HSA-350054 7.588382e-01 0.120 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.588382e-01 0.120 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 7.588382e-01 0.120 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 7.588382e-01 0.120 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 7.588382e-01 0.120 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 7.607318e-01 0.119 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 7.607318e-01 0.119 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 7.641205e-01 0.117 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 7.641205e-01 0.117 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 7.641205e-01 0.117 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 7.654998e-01 0.116 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.697832e-01 0.114 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 7.697832e-01 0.114 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 7.697832e-01 0.114 0 0
Plasmalogen biosynthesis R-HSA-75896 7.697832e-01 0.114 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 7.697832e-01 0.114 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 7.697832e-01 0.114 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 7.697832e-01 0.114 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 7.702795e-01 0.113 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 7.723281e-01 0.112 0 0
Signaling by TGFBR3 R-HSA-9839373 7.732021e-01 0.112 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.756265e-01 0.110 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.756265e-01 0.110 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 7.756265e-01 0.110 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 7.756265e-01 0.110 0 0
Biosynthesis of maresins R-HSA-9018682 7.756265e-01 0.110 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 7.756265e-01 0.110 0 0
Interleukin-20 family signaling R-HSA-8854691 7.756265e-01 0.110 0 0
Transferrin endocytosis and recycling R-HSA-917977 7.780317e-01 0.109 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 7.780317e-01 0.109 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.780317e-01 0.109 0 0
Signalling to ERKs R-HSA-187687 7.780317e-01 0.109 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 7.780317e-01 0.109 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 7.790781e-01 0.108 0 0
ECM proteoglycans R-HSA-3000178 7.836140e-01 0.106 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 7.912603e-01 0.102 0 0
RNA Polymerase III Transcription R-HSA-74158 7.912603e-01 0.102 0 0
RUNX2 regulates bone development R-HSA-8941326 7.912603e-01 0.102 0 0
Triglyceride catabolism R-HSA-163560 7.912603e-01 0.102 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 7.912667e-01 0.102 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.912667e-01 0.102 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 7.912667e-01 0.102 0 0
Acetylation R-HSA-156582 7.912667e-01 0.102 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 7.912667e-01 0.102 0 0
Conjugation of salicylate with glycine R-HSA-177128 7.912667e-01 0.102 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 7.912667e-01 0.102 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 7.912667e-01 0.102 0 0
Polymerase switching R-HSA-69091 7.912667e-01 0.102 0 0
Leading Strand Synthesis R-HSA-69109 7.912667e-01 0.102 0 0
Maple Syrup Urine Disease R-HSA-9865114 7.912667e-01 0.102 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 7.912667e-01 0.102 0 0
Signaling by LTK R-HSA-9842663 7.912667e-01 0.102 0 0
OAS antiviral response R-HSA-8983711 7.912667e-01 0.102 0 0
Thromboxane signalling through TP receptor R-HSA-428930 7.913831e-01 0.102 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 7.913831e-01 0.102 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.913831e-01 0.102 0 0
Plasma lipoprotein assembly R-HSA-8963898 7.913831e-01 0.102 0 0
Interleukin-6 family signaling R-HSA-6783589 7.913831e-01 0.102 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 7.933381e-01 0.101 0 0
RAB geranylgeranylation R-HSA-8873719 7.937554e-01 0.100 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 7.937554e-01 0.100 0 0
Mitochondrial protein degradation R-HSA-9837999 7.963057e-01 0.099 0 0
FCERI mediated NF-kB activation R-HSA-2871837 7.984462e-01 0.098 0 0
Ca2+ pathway R-HSA-4086398 8.027233e-01 0.095 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.061543e-01 0.094 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 8.061543e-01 0.094 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 8.061543e-01 0.094 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 8.061543e-01 0.094 0 0
G protein gated Potassium channels R-HSA-1296059 8.061543e-01 0.094 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 8.061543e-01 0.094 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.061543e-01 0.094 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 8.107466e-01 0.091 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 8.107466e-01 0.091 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 8.107466e-01 0.091 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.107466e-01 0.091 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 8.107466e-01 0.091 0 0
Processing of SMDT1 R-HSA-8949664 8.107466e-01 0.091 0 0
Frs2-mediated activation R-HSA-170968 8.107466e-01 0.091 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 8.135697e-01 0.090 0 0
Heme signaling R-HSA-9707616 8.135697e-01 0.090 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 8.157489e-01 0.088 0 0
MET activates PTK2 signaling R-HSA-8874081 8.199866e-01 0.086 0 0
TRP channels R-HSA-3295583 8.199866e-01 0.086 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.199866e-01 0.086 0 0
Potassium Channels R-HSA-1296071 8.202309e-01 0.086 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 8.270507e-01 0.082 0 0
Removal of the Flap Intermediate R-HSA-69166 8.284095e-01 0.082 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.284095e-01 0.082 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 8.284095e-01 0.082 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.284095e-01 0.082 0 0
Physiological factors R-HSA-5578768 8.284095e-01 0.082 0 0
Prolactin receptor signaling R-HSA-1170546 8.284095e-01 0.082 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.284095e-01 0.082 0 0
HDL assembly R-HSA-8963896 8.284095e-01 0.082 0 0
Zinc transporters R-HSA-435354 8.284095e-01 0.082 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.329267e-01 0.079 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.329267e-01 0.079 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.444250e-01 0.073 0 0
Erythropoietin activates RAS R-HSA-9027284 8.444250e-01 0.073 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.444250e-01 0.073 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.444250e-01 0.073 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 8.444250e-01 0.073 0 0
Processive synthesis on the lagging strand R-HSA-69183 8.444250e-01 0.073 0 0
Biotin transport and metabolism R-HSA-196780 8.444250e-01 0.073 0 0
Other semaphorin interactions R-HSA-416700 8.444250e-01 0.073 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.450206e-01 0.073 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.450206e-01 0.073 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 8.450206e-01 0.073 0 0
Insulin receptor recycling R-HSA-77387 8.450206e-01 0.073 0 0
Inflammasomes R-HSA-622312 8.450206e-01 0.073 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.450206e-01 0.073 0 0
Nucleotide biosynthesis R-HSA-8956320 8.466152e-01 0.072 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 8.471265e-01 0.072 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 8.548649e-01 0.068 0 0
mRNA Capping R-HSA-72086 8.563134e-01 0.067 0 0
DARPP-32 events R-HSA-180024 8.563134e-01 0.067 0 0
Glucagon-type ligand receptors R-HSA-420092 8.563134e-01 0.067 0 0
SLC-mediated transport of amino acids R-HSA-9958863 8.564595e-01 0.067 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.574504e-01 0.067 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.574504e-01 0.067 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 8.589465e-01 0.066 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.589465e-01 0.066 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.589465e-01 0.066 0 0
Prolonged ERK activation events R-HSA-169893 8.589465e-01 0.066 0 0
Activation of the phototransduction cascade R-HSA-2485179 8.589465e-01 0.066 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.589465e-01 0.066 0 0
Atorvastatin ADME R-HSA-9754706 8.589465e-01 0.066 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 8.589465e-01 0.066 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 8.589465e-01 0.066 0 0
Fructose catabolism R-HSA-70350 8.589465e-01 0.066 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 8.589465e-01 0.066 0 0
Attachment and Entry R-HSA-9678110 8.589465e-01 0.066 0 0
Paracetamol ADME R-HSA-9753281 8.634986e-01 0.064 0 0
Formation of the cornified envelope R-HSA-6809371 8.661636e-01 0.062 0 0
Activation of GABAB receptors R-HSA-991365 8.664900e-01 0.062 0 0
GABA B receptor activation R-HSA-977444 8.664900e-01 0.062 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.668492e-01 0.062 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 8.713266e-01 0.060 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 8.721133e-01 0.059 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 8.721133e-01 0.059 0 0
Fibronectin matrix formation R-HSA-1566977 8.721133e-01 0.059 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 8.721133e-01 0.059 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 8.721133e-01 0.059 0 0
Passive transport by Aquaporins R-HSA-432047 8.721133e-01 0.059 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.721133e-01 0.059 0 0
Galactose catabolism R-HSA-70370 8.721133e-01 0.059 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 8.721133e-01 0.059 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.733051e-01 0.059 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.766711e-01 0.057 0 0
Integration of energy metabolism R-HSA-163685 8.814331e-01 0.055 0 0
DAP12 interactions R-HSA-2172127 8.830639e-01 0.054 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 8.840518e-01 0.054 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 8.840518e-01 0.054 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.840518e-01 0.054 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 8.840518e-01 0.054 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 8.840518e-01 0.054 0 0
Sulfide oxidation to sulfate R-HSA-1614517 8.840518e-01 0.054 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 8.840518e-01 0.054 0 0
Choline catabolism R-HSA-6798163 8.840518e-01 0.054 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.840518e-01 0.054 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 8.840518e-01 0.054 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.858203e-01 0.053 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.858261e-01 0.053 0 0
Extension of Telomeres R-HSA-180786 8.925264e-01 0.049 0 0
Amino acid transport across the plasma membrane R-HSA-352230 8.925264e-01 0.049 0 0
Mitochondrial biogenesis R-HSA-1592230 8.927304e-01 0.049 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 8.943369e-01 0.048 0 0
FGFR1 mutant receptor activation R-HSA-1839124 8.943369e-01 0.048 0 0
PKA activation R-HSA-163615 8.948764e-01 0.048 0 0
PKA activation in glucagon signalling R-HSA-164378 8.948764e-01 0.048 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 8.948764e-01 0.048 0 0
Tie2 Signaling R-HSA-210993 8.948764e-01 0.048 0 0
Mismatch Repair R-HSA-5358508 8.948764e-01 0.048 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 8.948764e-01 0.048 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 8.948764e-01 0.048 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.977779e-01 0.047 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.977779e-01 0.047 0 0
Diseases of DNA repair R-HSA-9675135 8.977779e-01 0.047 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.993758e-01 0.046 0 0
Leishmania phagocytosis R-HSA-9664417 8.993758e-01 0.046 0 0
Parasite infection R-HSA-9664407 8.993758e-01 0.046 0 0
Resolution of D-Loop Structures R-HSA-5693537 9.022592e-01 0.045 0 0
Signaling by FGFR in disease R-HSA-1226099 9.023890e-01 0.045 0 0
Germ layer formation at gastrulation R-HSA-9754189 9.046910e-01 0.043 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.046910e-01 0.043 0 0
Specification of the neural plate border R-HSA-9834899 9.046910e-01 0.043 0 0
Conjugation of carboxylic acids R-HSA-159424 9.046910e-01 0.043 0 0
Amino Acid conjugation R-HSA-156587 9.046910e-01 0.043 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.046910e-01 0.043 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.046910e-01 0.043 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.046910e-01 0.043 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.046910e-01 0.043 0 0
Other interleukin signaling R-HSA-449836 9.046910e-01 0.043 0 0
Aquaporin-mediated transport R-HSA-445717 9.048985e-01 0.043 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.104888e-01 0.041 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.105982e-01 0.041 0 0
FOXO-mediated transcription R-HSA-9614085 9.119742e-01 0.040 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.135899e-01 0.039 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.135899e-01 0.039 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.135899e-01 0.039 0 0
Signaling by NODAL R-HSA-1181150 9.135899e-01 0.039 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.135899e-01 0.039 0 0
Pregnenolone biosynthesis R-HSA-196108 9.135899e-01 0.039 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.135899e-01 0.039 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.174466e-01 0.037 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.177846e-01 0.037 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.216583e-01 0.035 0 0
Lagging Strand Synthesis R-HSA-69186 9.216583e-01 0.035 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 9.216583e-01 0.035 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.216583e-01 0.035 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.216583e-01 0.035 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.216583e-01 0.035 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.223029e-01 0.035 0 0
PI3K Cascade R-HSA-109704 9.223029e-01 0.035 0 0
GPVI-mediated activation cascade R-HSA-114604 9.228190e-01 0.035 0 0
Voltage gated Potassium channels R-HSA-1296072 9.287144e-01 0.032 0 0
Androgen biosynthesis R-HSA-193048 9.289738e-01 0.032 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.289738e-01 0.032 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 9.289738e-01 0.032 0 0
Serine metabolism R-HSA-977347 9.289738e-01 0.032 0 0
Glucocorticoid biosynthesis R-HSA-194002 9.289738e-01 0.032 0 0
Glutathione synthesis and recycling R-HSA-174403 9.289738e-01 0.032 0 0
Attachment and Entry R-HSA-9694614 9.289738e-01 0.032 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.356066e-01 0.029 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.356066e-01 0.029 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.356066e-01 0.029 0 0
Signaling by KIT in disease R-HSA-9669938 9.356066e-01 0.029 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.356066e-01 0.029 0 0
LDL clearance R-HSA-8964038 9.356066e-01 0.029 0 0
Fructose metabolism R-HSA-5652084 9.356066e-01 0.029 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.356066e-01 0.029 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.370246e-01 0.028 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.392510e-01 0.027 0 0
Signaling by ALK R-HSA-201556 9.392510e-01 0.027 0 0
Peptide hormone metabolism R-HSA-2980736 9.414441e-01 0.026 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.416203e-01 0.026 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.416203e-01 0.026 0 0
Formation of the ureteric bud R-HSA-9830674 9.416203e-01 0.026 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.416203e-01 0.026 0 0
Growth hormone receptor signaling R-HSA-982772 9.416203e-01 0.026 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.422796e-01 0.026 0 0
CYP2E1 reactions R-HSA-211999 9.470728e-01 0.024 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.470728e-01 0.024 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.470728e-01 0.024 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.470728e-01 0.024 0 0
Complex III assembly R-HSA-9865881 9.470728e-01 0.024 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.470728e-01 0.024 0 0
Maturation of spike protein R-HSA-9694548 9.482970e-01 0.023 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.520163e-01 0.021 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.520163e-01 0.021 0 0
Hyaluronan degradation R-HSA-2160916 9.520163e-01 0.021 0 0
Formation of the nephric duct R-HSA-9830364 9.520163e-01 0.021 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.520163e-01 0.021 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.520163e-01 0.021 0 0
Intra-Golgi traffic R-HSA-6811438 9.523233e-01 0.021 0 0
IRS-mediated signalling R-HSA-112399 9.526573e-01 0.021 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.547311e-01 0.020 0 0
Aspirin ADME R-HSA-9749641 9.558669e-01 0.020 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.560489e-01 0.020 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 9.564983e-01 0.019 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.564983e-01 0.019 0 0
Urea cycle R-HSA-70635 9.564983e-01 0.019 0 0
Sphingolipid catabolism R-HSA-9845614 9.564983e-01 0.019 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.564983e-01 0.019 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.564983e-01 0.019 0 0
Parasitic Infection Pathways R-HSA-9824443 9.581853e-01 0.019 0 0
Leishmania infection R-HSA-9658195 9.581853e-01 0.019 0 0
Triglyceride metabolism R-HSA-8979227 9.590371e-01 0.018 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.605619e-01 0.017 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 9.605619e-01 0.017 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.613637e-01 0.017 0 0
GABA receptor activation R-HSA-977443 9.619156e-01 0.017 0 0
Methylation R-HSA-156581 9.626807e-01 0.017 0 0
Telomere Extension By Telomerase R-HSA-171319 9.642461e-01 0.016 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.642461e-01 0.016 0 0
Prednisone ADME R-HSA-9757110 9.642461e-01 0.016 0 0
Pyroptosis R-HSA-5620971 9.642461e-01 0.016 0 0
PI Metabolism R-HSA-1483255 9.642491e-01 0.016 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.646031e-01 0.016 0 0
Neurotransmitter release cycle R-HSA-112310 9.646844e-01 0.016 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.656252e-01 0.015 0 0
Thyroxine biosynthesis R-HSA-209968 9.675864e-01 0.014 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.675864e-01 0.014 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 9.706148e-01 0.013 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 9.706148e-01 0.013 0 0
Neurotransmitter clearance R-HSA-112311 9.706148e-01 0.013 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.706148e-01 0.013 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 9.706148e-01 0.013 0 0
Signaling by Insulin receptor R-HSA-74752 9.707807e-01 0.013 0 0
Insulin receptor signalling cascade R-HSA-74751 9.716321e-01 0.012 0 0
IGF1R signaling cascade R-HSA-2428924 9.716321e-01 0.012 0 0
Metal ion SLC transporters R-HSA-425410 9.731769e-01 0.012 0 0
Cargo concentration in the ER R-HSA-5694530 9.733604e-01 0.012 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.736654e-01 0.012 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.742729e-01 0.011 0 0
Adipogenesis R-HSA-9843745 9.749739e-01 0.011 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.753174e-01 0.011 0 0
DAG1 glycosylations R-HSA-8931838 9.758496e-01 0.011 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.772922e-01 0.010 0 0
Cardiogenesis R-HSA-9733709 9.781063e-01 0.010 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.781063e-01 0.010 0 0
Recycling of bile acids and salts R-HSA-159418 9.781063e-01 0.010 0 0
Complex IV assembly R-HSA-9864848 9.791137e-01 0.009 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.799207e-01 0.009 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.801523e-01 0.009 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.801523e-01 0.009 0 0
Hyaluronan metabolism R-HSA-2142845 9.820072e-01 0.008 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.820072e-01 0.008 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.820072e-01 0.008 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.820072e-01 0.008 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.836889e-01 0.007 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.836889e-01 0.007 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.836889e-01 0.007 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.852134e-01 0.006 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.865956e-01 0.006 0 0
Metabolism of folate and pterines R-HSA-196757 9.865956e-01 0.006 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.866767e-01 0.006 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.878486e-01 0.005 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.878486e-01 0.005 0 0
Diseases associated with N-glycosylation of proteins R-HSA-3781860 9.889846e-01 0.005 0 0
G alpha (q) signalling events R-HSA-416476 9.893773e-01 0.005 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.893781e-01 0.005 0 0
Peptide ligand-binding receptors R-HSA-375276 9.899093e-01 0.004 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.900144e-01 0.004 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.900144e-01 0.004 0 0
Tryptophan catabolism R-HSA-71240 9.900144e-01 0.004 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.900144e-01 0.004 0 0
Interleukin-2 family signaling R-HSA-451927 9.900144e-01 0.004 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.909480e-01 0.004 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.909516e-01 0.004 0 0
Collagen formation R-HSA-1474290 9.910874e-01 0.004 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.917944e-01 0.004 0 0
HIV Transcription Initiation R-HSA-167161 9.917944e-01 0.004 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.917944e-01 0.004 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.917944e-01 0.004 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.924579e-01 0.003 0 0
Xenobiotics R-HSA-211981 9.930794e-01 0.003 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.932573e-01 0.003 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.938878e-01 0.003 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.938897e-01 0.003 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.941758e-01 0.003 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.944595e-01 0.002 0 0
Metabolism of steroid hormones R-HSA-196071 9.946582e-01 0.002 0 0
Kidney development R-HSA-9830369 9.946582e-01 0.002 0 0
Nicotinate metabolism R-HSA-196807 9.946582e-01 0.002 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.951013e-01 0.002 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.951803e-01 0.002 0 0
G alpha (s) signalling events R-HSA-418555 9.952354e-01 0.002 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.958733e-01 0.002 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.958821e-01 0.002 0 0
Transport of small molecules R-HSA-382551 9.960677e-01 0.002 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.961364e-01 0.002 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.962253e-01 0.002 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.962593e-01 0.002 0 0
Drug ADME R-HSA-9748784 9.964266e-01 0.002 0 0
Visual phototransduction R-HSA-2187338 9.964890e-01 0.002 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.964981e-01 0.002 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.969265e-01 0.001 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.974625e-01 0.001 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.979544e-01 0.001 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.979544e-01 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 9.979544e-01 0.001 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.981194e-01 0.001 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.981659e-01 0.001 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.981834e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.982954e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.982954e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.983433e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.983433e-01 0.001 0 0
Interferon gamma signaling R-HSA-877300 9.984111e-01 0.001 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.984296e-01 0.001 0 0
Regulation of beta-cell development R-HSA-186712 9.985996e-01 0.001 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.986325e-01 0.001 0 0
Keratinization R-HSA-6805567 9.986796e-01 0.001 0 0
Metabolism of nucleotides R-HSA-15869 9.987168e-01 0.001 0 0
Glutathione conjugation R-HSA-156590 9.987306e-01 0.001 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.987306e-01 0.001 0 0
Endogenous sterols R-HSA-211976 9.988495e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.990548e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.990548e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.990582e-01 0.000 0 0
PPARA activates gene expression R-HSA-1989781 9.993235e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.994219e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.994640e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.995251e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.995481e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.995498e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.995696e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.996099e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.996223e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.996796e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.997096e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.997450e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.997760e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.997778e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.998041e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.998041e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.998837e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999188e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999391e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.999571e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999600e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999727e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999746e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999775e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999794e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999797e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999853e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999863e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999892e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999913e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999921e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999931e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999957e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999967e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.999977e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.999978e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999988e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999990e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 9.999990e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999998e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.999998e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.999998e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999999e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999999e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999999e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways