PASK

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

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substrate_uniprot	site	source	substrate_genes	site_seq
O14974	S695	Sugiyama	PPP1R12A MBS MYPT1	DEEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSR
O60814	S37	Sugiyama	H2BC12 H2BFT HIRIP1 HIST1H2BK	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
O95218	S181	Sugiyama	ZRANB2 ZIS ZNF265	DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075	S46	Sugiyama	ALDOA ALDA	PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04406	S210	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	GPsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtG
P04406	T211	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	PsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtGM
P04406	T237	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P06899	S37	Sugiyama	H2BC11 H2BFR HIST1H2BJ	KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISS
P08238	S462	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P11142	T163	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P13639	S593	Sugiyama	EEF2 EF2	SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13639	T5	Sugiyama	EEF2 EF2	________________MVNFtVDQIRAIMDKKANIRNMsVI
P13861	S99	Sugiyama	PRKAR2A PKR2 PRKAR2	EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P18615	S115	Sugiyama	NELFE RD RDBP	KLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLyEs
P23527	S37	Sugiyama	H2BC17 H2BFH H2BFN HIST1H2BO	KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISS
P26038	T526	Sugiyama	MSN	EERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHA
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26641	T287	Sugiyama	EEF1G EF1G PRO1608	EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P31327	T45	Sugiyama	CPS1	AHQKWKFSRPGIRLLSVKAQtAHIVLEDGtKMKGYSFGHPS
P33778	S37	Sugiyama	H2BC3 H2BFF HIST1H2BB	KAITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISS
P35269	T156	Sugiyama	GTF2F1 RAP74	EAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHFSI
P37108	S25	Sugiyama	SRP14	EsEQFLtELTRLFQKCRTSGsVyItLKKYDGRTKPIPKKGt
P37802	S163	Sugiyama	TAGLN2 KIAA0120 CDABP0035	LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37837	S13	Sugiyama	TALDO1 TAL TALDO TALDOR	________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P43487	S60	Sugiyama	RANBP1	TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46776	S68	Sugiyama	RPL27A	yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777	S176	Sugiyama	RPL5 MSTP030	GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P46937	S109	Sugiyama	YAP1 YAP65	RKLPDsFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssP
P46937	T114	Sugiyama	YAP1 YAP65	sFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssPAsLQL
P52747	T352	Sugiyama	ZNF143 SBF STAF	EGCGRSFTTSNIRKVHVRTHtGERPYyCTEPGCGRAFASAT
P57053	S37	Sugiyama	H2BC12L H2BFS H2BS1	KAVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIss
P58876	S37	Sugiyama	H2BC5 H2BFB HIRIP2 HIST1H2BD	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
P60709	S52	Sugiyama	ACTB	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P61964	S49	PSP	WDR5 BIG3	tPVKPNYALKFTLAGHTKAVsSVKFSPNGEWLASSSADKLI
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62277	S12	Sugiyama	RPS13	_________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62736	S54	Sugiyama	ACTA2 ACTSA ACTVS GIG46	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62753	S235	EPSD	RPS6 OK/SW-cl.2	KRMKEAKEKRQEQIAKRRRLssLRAstsKsEssQK______
P62753	S236	EPSD	RPS6 OK/SW-cl.2	RMKEAKEKRQEQIAKRRRLssLRAstsKsEssQK_______
P62807	S37	Sugiyama	H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI	KAVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIss
P63261	S52	Sugiyama	ACTG1 ACTG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63267	S53	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P67809	T108	Sugiyama	YBX1 NSEP1 YB1	QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P68032	S54	Sugiyama	ACTC1 ACTC	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68104	T432	EPSD\|PSP	EEF1A1 EEF1A EF1A LENG7	VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133	S54	Sugiyama	ACTA1 ACTA	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P84098	S12	Sugiyama	RPL19	_________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
Q02878	Y216	Sugiyama	RPL6 TXREB1	AtsTKIDISNVKIPKHLtDAyFKKKKLRKPRHQEGEIFDtE
Q13442	T18	Sugiyama	PDAP1 HASPP28	___MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEE
Q15080	S67	Sugiyama	NCF4 SH3PXD4	TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q16778	S37	Sugiyama	H2BC21 H2BFQ HIST2H2BE	KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIss
Q5QNW6	S37	Sugiyama	H2BC18 HIST2H2BF	KAVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q6DN03	S37	Sugiyama	H2BC20P HIST2H2BC	KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWC
Q6DRA6	S37	Sugiyama	H2BC19P HIST2H2BD	KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWC
Q86VQ1	S223	Sugiyama	GLCCI1	QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q8N257	S37	Sugiyama	H2BC26 H2BU1 HIST3H2BB	KAVTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIss
Q92597	T366	Sugiyama	NDRG1 CAP43 DRG1 RTP	tSEGTRsRsHtsEGtRsRsHtsEGAHLDItPNsGAAGNsAG
Q93079	S37	Sugiyama	H2BC9 H2BFJ HIST1H2BH	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q96RG2	S1273	Sugiyama	PASK KIAA0135	QPVNLADYTWEEVFRVNKPEsGVLsAAsLEMGNRsLsDVAQ
Q96RG2	S1277	Sugiyama	PASK KIAA0135	LADYTWEEVFRVNKPEsGVLsAAsLEMGNRsLsDVAQAQEL
Q96RG2	S1280	Sugiyama	PASK KIAA0135	YTWEEVFRVNKPEsGVLsAAsLEMGNRsLsDVAQAQELCGG
Q96RG2	S996	Sugiyama	PASK KIAA0135	FEEPPKAVELEGLAACEGEYsQKYSTMSPLGSGAFGFVWTA
Q96RG2	T1161	ELM\|iPTMNet\|EPSD\|PSP	PASK KIAA0135	TIKLIDFGSAAYLERGKLFYtFCGtIEYCAPEVLMGNPYRG
Q96RG2	T1165	ELM\|iPTMNet\|EPSD\|PSP	PASK KIAA0135	IDFGSAAYLERGKLFYtFCGtIEYCAPEVLMGNPYRGPELE
Q96RG2	T307	PSP	PASK KIAA0135	GQHIPKNLKIQRSVGRARDGtTFPLSLKLKSQPSSEEATTG
Q99877	S37	Sugiyama	H2BC15 H2BFD HIST1H2BN	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99879	S37	Sugiyama	H2BC14 H2BFE HIST1H2BM	KAINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99880	S37	Sugiyama	H2BC13 H2BFC HIST1H2BL	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q9UGV2	S327	Sugiyama	NDRG3	KYFLQGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsV
Q9UGV2	S334	Sugiyama	NDRG3	GYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsDG
Q9UGV2	T332	Sugiyama	NDRG3	GMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQs
Q9Y2I7	S307	Sugiyama	PIKFYVE KIAA0981 PIP5K3	TRLVSVQEDAGKsPARNRsAsItNLsLDRsGsPMVPSYEts
Q9Y2T7	T143	Sugiyama	YBX2 CSDA3 MSY2	QtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEATNVTGP

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Transport of the SLBP independent Mature mRNA	R-HSA-159227	0.000008	5.087
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	0.000010	4.993
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	0.000024	4.625
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	0.000033	4.482
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	0.000039	4.405
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	0.000053	4.277
Signaling by Hippo	R-HSA-2028269	0.000049	4.307
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	0.000055	4.262
Cell Cycle	R-HSA-1640170	0.000052	4.284
Nuclear Envelope Breakdown	R-HSA-2980766	0.000124	3.907
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	0.000148	3.829
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	0.000150	3.824
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	0.000172	3.765
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	0.000206	3.686
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	0.000206	3.686
Interactions of Rev with host cellular proteins	R-HSA-177243	0.000206	3.686
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	0.000224	3.651
Apoptotic cleavage of cellular proteins	R-HSA-111465	0.000246	3.609
IPs transport between nucleus and cytosol	R-HSA-1855170	0.000292	3.534
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	0.000345	3.462
Nuclear import of Rev protein	R-HSA-180746	0.000406	3.392
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	0.000475	3.324
Transcriptional Regulation by TP53	R-HSA-3700989	0.000475	3.323
Membrane Trafficking	R-HSA-199991	0.000501	3.300
Vpr-mediated nuclear import of PICs	R-HSA-180910	0.000641	3.193
Cell Cycle, Mitotic	R-HSA-69278	0.000694	3.159
Viral Messenger RNA Synthesis	R-HSA-168325	0.000813	3.090
NS1 Mediated Effects on Host Pathways	R-HSA-168276	0.000851	3.070
Interactions of Vpr with host cellular proteins	R-HSA-176033	0.000975	3.011
Mitotic Spindle Checkpoint	R-HSA-69618	0.001032	2.986
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	0.001082	2.966
M Phase	R-HSA-68886	0.001132	2.946
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	0.001113	2.954
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	0.001234	2.909
Signal Transduction	R-HSA-162582	0.001204	2.919
mTORC1-mediated signalling	R-HSA-166208	0.001324	2.878
MTOR signalling	R-HSA-165159	0.001435	2.843
Late Phase of HIV Life Cycle	R-HSA-162599	0.001491	2.827
Rab regulation of trafficking	R-HSA-9007101	0.001579	2.802
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	0.002054	2.687
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	0.002190	2.659
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	0.002190	2.659
Transcriptional activation of p53 responsive genes	R-HSA-69560	0.002190	2.659
Oncogenic MAPK signaling	R-HSA-6802957	0.002262	2.645
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	0.002301	2.638
Apoptotic execution phase	R-HSA-75153	0.002301	2.638
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	0.002453	2.610
Amplification of signal from the kinetochores	R-HSA-141424	0.002453	2.610
snRNP Assembly	R-HSA-191859	0.002419	2.616
Metabolism of non-coding RNA	R-HSA-194441	0.002419	2.616
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	0.002571	2.590
Inositol phosphate metabolism	R-HSA-1483249	0.002683	2.571
Mitotic Anaphase	R-HSA-68882	0.002851	2.545
Mitotic Metaphase and Anaphase	R-HSA-2555396	0.002986	2.525
ISG15 antiviral mechanism	R-HSA-1169408	0.003091	2.510
HIV Life Cycle	R-HSA-162587	0.003556	2.449
Cell Cycle Checkpoints	R-HSA-69620	0.004045	2.393
Formation of RNA Pol II elongation complex	R-HSA-112382	0.004313	2.365
Gene expression (Transcription)	R-HSA-74160	0.004422	2.354
RNA Polymerase II Transcription Elongation	R-HSA-75955	0.004751	2.323
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	0.004881	2.311
Regulation of CDH19 Expression and Function	R-HSA-9764302	0.004881	2.311
Mitotic Prophase	R-HSA-68875	0.005073	2.295
Cellular response to heat stress	R-HSA-3371556	0.005384	2.269
Diseases of mitotic cell cycle	R-HSA-9675126	0.005846	2.233
Nuclear RNA decay	R-HSA-9930044	0.006600	2.180
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	0.006600	2.180
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	0.006600	2.180
Host Interactions of HIV factors	R-HSA-162909	0.006412	2.193
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	0.007010	2.154
Transcriptional regulation by small RNAs	R-HSA-5578749	0.007466	2.127
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	0.008092	2.092
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	0.008895	2.051
Regulation of PTEN gene transcription	R-HSA-8943724	0.008829	2.054
Cell-extracellular matrix interactions	R-HSA-446353	0.008895	2.051
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	0.008966	2.047
Regulation of endogenous retroelements	R-HSA-9842860	0.009264	2.033
VEGFA-VEGFR2 Pathway	R-HSA-4420097	0.009438	2.025
Nervous system development	R-HSA-9675108	0.009481	2.023
HIV Infection	R-HSA-162906	0.009533	2.021
SWI/SNF chromatin remodelers	R-HSA-9932451	0.010561	1.976
ATP-dependent chromatin remodelers	R-HSA-9932444	0.010561	1.976
Axon guidance	R-HSA-422475	0.009976	2.001
tRNA processing in the nucleus	R-HSA-6784531	0.010371	1.984
Chromatin organization	R-HSA-4839726	0.011196	1.951
Separation of Sister Chromatids	R-HSA-2467813	0.011351	1.945
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	0.011458	1.941
Regulation of TP53 Expression	R-HSA-6804754	0.012565	1.901
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	0.012388	1.907
Chromatin modifying enzymes	R-HSA-3247509	0.012454	1.905
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	0.012441	1.905
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	0.013069	1.884
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	0.013152	1.881
Signaling by ALK in cancer	R-HSA-9700206	0.013152	1.881
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	0.013501	1.870
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	0.013501	1.870
Inactivation of CDC42 and RAC1	R-HSA-428543	0.014574	1.836
HIV elongation arrest and recovery	R-HSA-167287	0.015159	1.819
Pausing and recovery of HIV elongation	R-HSA-167290	0.015159	1.819
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	0.013968	1.855
Specification of primordial germ cells	R-HSA-9827857	0.014510	1.838
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	0.014690	1.833
HIV Transcription Elongation	R-HSA-167169	0.015357	1.814
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	0.015357	1.814
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	0.015357	1.814
PIP3 activates AKT signaling	R-HSA-1257604	0.015519	1.809
Ephrin signaling	R-HSA-3928664	0.016783	1.775
Regulation of CDH11 function	R-HSA-9762292	0.017974	1.745
VEGFR2 mediated vascular permeability	R-HSA-5218920	0.016839	1.774
Regulation of CDH11 Expression and Function	R-HSA-9759475	0.016948	1.771
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	0.017974	1.745
Signaling by VEGF	R-HSA-194138	0.016840	1.774
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	0.016783	1.775
Signaling by RAF1 mutants	R-HSA-9656223	0.018416	1.735
MAP2K and MAPK activation	R-HSA-5674135	0.018416	1.735
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	0.018871	1.724
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	0.019267	1.715
Rap1 signalling	R-HSA-392517	0.019267	1.715
Clathrin-mediated endocytosis	R-HSA-8856828	0.020382	1.691
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	0.021968	1.658
EPHB-mediated forward signaling	R-HSA-3928662	0.023746	1.624
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	0.022598	1.646
RNA Polymerase II Pre-transcription Events	R-HSA-674695	0.024067	1.619
TBC/RABGAPs	R-HSA-8854214	0.021867	1.660
PI Metabolism	R-HSA-1483255	0.022819	1.642
Vesicle-mediated transport	R-HSA-5653656	0.024109	1.618
PI3K/AKT Signaling in Cancer	R-HSA-2219528	0.025673	1.591
PLCG1 events in ERBB2 signaling	R-HSA-1251932	0.026766	1.572
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	0.026766	1.572
MITF-M-dependent gene expression	R-HSA-9856651	0.027426	1.562
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	0.027821	1.556
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	0.027821	1.556
Signaling downstream of RAS mutants	R-HSA-9649948	0.027821	1.556
Signaling by RAS mutants	R-HSA-6802949	0.027821	1.556
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	0.028031	1.552
Transcriptional regulation of granulopoiesis	R-HSA-9616222	0.029987	1.523
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	0.029987	1.523
EPH-Ephrin signaling	R-HSA-2682334	0.030294	1.519
Repression of WNT target genes	R-HSA-4641265	0.030596	1.514
PTEN Regulation	R-HSA-6807070	0.034455	1.463
Influenza Viral RNA Transcription and Replication	R-HSA-168273	0.033449	1.476
AKT phosphorylates targets in the cytosol	R-HSA-198323	0.030596	1.514
Cellular responses to stress	R-HSA-2262752	0.034235	1.466
Intracellular signaling by second messengers	R-HSA-9006925	0.034744	1.459
DNA Damage Bypass	R-HSA-73893	0.034757	1.459
IRS activation	R-HSA-74713	0.035452	1.450
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	0.035608	1.448
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	0.035608	1.448
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	0.035608	1.448
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	0.035608	1.448
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	0.035608	1.448
RUNX2 regulates bone development	R-HSA-8941326	0.036372	1.439
RNA Polymerase II Transcription	R-HSA-73857	0.036827	1.434
Mitotic Prometaphase	R-HSA-68877	0.036883	1.433
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	0.041053	1.387
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	0.041053	1.387
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	0.045066	1.346
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	0.045066	1.346
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	0.038822	1.411
Negative feedback regulation of MAPK pathway	R-HSA-5674499	0.045066	1.346
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	0.039478	1.404
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	0.040778	1.390
Cellular Senescence	R-HSA-2559583	0.044368	1.353
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	0.045066	1.346
Sodium-coupled phosphate cotransporters	R-HSA-427652	0.045066	1.346
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	0.046160	1.336
Signaling by ALK	R-HSA-201556	0.046160	1.336
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	0.046417	1.333
Sema3A PAK dependent Axon repulsion	R-HSA-399954	0.046810	1.330
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	0.047147	1.327
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	0.047161	1.326
Myogenesis	R-HSA-525793	0.047161	1.326
Glycolysis	R-HSA-70171	0.047165	1.326
Cell-Cell communication	R-HSA-1500931	0.048527	1.314
XBP1(S) activates chaperone genes	R-HSA-381038	0.049556	1.305
Cell junction organization	R-HSA-446728	0.049929	1.302
Golgi-to-ER retrograde transport	R-HSA-8856688	0.050797	1.294
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	0.055515	1.256
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	0.052985	1.276
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	0.059530	1.225
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	0.056415	1.249
Formation of the Early Elongation Complex	R-HSA-113418	0.056415	1.249
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	0.061381	1.212
mRNA Splicing	R-HSA-72172	0.054210	1.266
Nucleotide Excision Repair	R-HSA-5696398	0.061335	1.212
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	0.051742	1.286
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	0.059530	1.225
RNA Polymerase I Transcription Initiation	R-HSA-73762	0.061426	1.212
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	0.051620	1.287
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	0.056415	1.249
Metabolism of RNA	R-HSA-8953854	0.053486	1.272
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	0.052985	1.276
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	0.054989	1.260
Dual incision in TC-NER	R-HSA-6782135	0.061843	1.209
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	0.062373	1.205
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	0.064978	1.187
Regulation of CDH1 Expression and Function	R-HSA-9764265	0.064978	1.187
IRE1alpha activates chaperones	R-HSA-381070	0.065670	1.183
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	0.066570	1.177
Gene Silencing by RNA	R-HSA-211000	0.066603	1.177
Regulation of PTEN localization	R-HSA-8948747	0.066717	1.176
SOS-mediated signalling	R-HSA-112412	0.066717	1.176
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	0.066717	1.176
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	0.066717	1.176
RUNX3 regulates WNT signaling	R-HSA-8951430	0.066717	1.176
Cell-cell junction organization	R-HSA-421270	0.068533	1.164
mRNA Splicing - Major Pathway	R-HSA-72163	0.068984	1.161
Generic Transcription Pathway	R-HSA-212436	0.069489	1.158
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	0.080422	1.095
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	0.080422	1.095
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	0.080422	1.095
Diseases of Telomere Maintenance	R-HSA-9673013	0.080422	1.095
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	0.080422	1.095
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	0.080422	1.095
Impaired BRCA2 translocation to the nucleus	R-HSA-9709275	0.080422	1.095
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	0.080422	1.095
Impaired BRCA2 binding to SEM1 (DSS1)	R-HSA-9763198	0.080422	1.095
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	0.080422	1.095
Signaling by MRAS-complex mutants	R-HSA-9660537	0.078590	1.105
Formation of annular gap junctions	R-HSA-196025	0.078590	1.105
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	0.078590	1.105
Signaling by ROBO receptors	R-HSA-376176	0.088837	1.051
Signaling by FGFR2 IIIa TM	R-HSA-8851708	0.081275	1.090
Adherens junctions interactions	R-HSA-418990	0.080692	1.093
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	0.083446	1.079
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	0.074534	1.128
Semaphorin interactions	R-HSA-373755	0.081089	1.091
Depolymerization of the Nuclear Lamina	R-HSA-4419969	0.073688	1.133
Signaling by NTRK1 (TRKA)	R-HSA-187037	0.082607	1.083
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	0.083446	1.079
NGF-stimulated transcription	R-HSA-9031628	0.089039	1.050
Cellular responses to stimuli	R-HSA-8953897	0.079298	1.101
Transcriptional regulation by RUNX3	R-HSA-8878159	0.088140	1.055
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	0.078590	1.105
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	0.078590	1.105
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	0.089039	1.050
Influenza Infection	R-HSA-168255	0.078045	1.108
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	0.089185	1.050
DNA Damage Recognition in GG-NER	R-HSA-5696394	0.089494	1.048
Gap junction degradation	R-HSA-190873	0.091062	1.041
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	0.091062	1.041
Regulation of CDH11 gene transcription	R-HSA-9762293	0.091062	1.041
TP53 Regulates Metabolic Genes	R-HSA-5628897	0.093738	1.028
S Phase	R-HSA-69242	0.094490	1.025
Signaling by NTRKs	R-HSA-166520	0.094490	1.025
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	0.095747	1.019
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	0.097403	1.011
MAPK family signaling cascades	R-HSA-5683057	0.097540	1.011
Transcriptional regulation by RUNX1	R-HSA-8878171	0.099045	1.004
Transcription of the HIV genome	R-HSA-167172	0.103304	0.986
Glucose metabolism	R-HSA-70326	0.104032	0.983
PI3K/AKT activation	R-HSA-198203	0.104064	0.983
Signal attenuation	R-HSA-74749	0.104064	0.983
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	0.104064	0.983
Josephin domain DUBs	R-HSA-5689877	0.104064	0.983
Signaling by Leptin	R-HSA-2586552	0.104064	0.983
HSF1-dependent transactivation	R-HSA-3371571	0.104894	0.979
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	0.105915	0.975
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	0.108208	0.966
mRNA 3'-end processing	R-HSA-72187	0.110469	0.957
Regulation of CDH1 Gene Transcription	R-HSA-9764560	0.112995	0.947
Estrogen-dependent gene expression	R-HSA-9018519	0.114284	0.942
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	0.114555	0.941
FGFR2 alternative splicing	R-HSA-6803529	0.114706	0.940
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	0.115681	0.937
Interactions of Tat with host cellular proteins	R-HSA-176034	0.118178	0.927
PTEN Loss of Function in Cancer	R-HSA-5674404	0.118178	0.927
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	0.118178	0.927
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	0.118178	0.927
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	0.154385	0.811
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	0.154385	0.811
Regulation of cortical dendrite branching	R-HSA-8985801	0.154385	0.811
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	0.154385	0.811
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	0.154385	0.811
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	0.154385	0.811
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	0.154385	0.811
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	0.154385	0.811
Potassium transport channels	R-HSA-1296067	0.154385	0.811
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	0.154385	0.811
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	0.154385	0.811
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	0.154385	0.811
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	0.154385	0.811
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	0.154385	0.811
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	0.131403	0.881
Deadenylation of mRNA	R-HSA-429947	0.133066	0.876
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	0.134145	0.872
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	0.139130	0.857
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	0.126226	0.899
Formation of Incision Complex in GG-NER	R-HSA-5696395	0.137259	0.862
Mitotic Telophase/Cytokinesis	R-HSA-68884	0.131403	0.881
VLDLR internalisation and degradation	R-HSA-8866427	0.145625	0.837
HCMV Early Events	R-HSA-9609690	0.123654	0.908
Signaling by FLT3 fusion proteins	R-HSA-9703465	0.152363	0.817
Regulation of PTEN mRNA translation	R-HSA-8943723	0.123761	0.907
Formation of the posterior neural plate	R-HSA-9832991	0.117531	0.930
Regulation of CDH1 Function	R-HSA-9764561	0.140393	0.853
Epigenetic regulation of gene expression	R-HSA-212165	0.137026	0.863
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	0.142605	0.846
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	0.154385	0.811
Signaling by FGFR in disease	R-HSA-1226099	0.133692	0.874
DNA Repair	R-HSA-73894	0.125207	0.902
Breakdown of the nuclear lamina	R-HSA-352238	0.118178	0.927
Transcriptional Regulation by E2F6	R-HSA-8953750	0.129894	0.886
HDMs demethylate histones	R-HSA-3214842	0.142605	0.846
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	0.140393	0.853
ChREBP activates metabolic gene expression	R-HSA-163765	0.117531	0.930
Regulation of TP53 Expression and Degradation	R-HSA-6806003	0.129894	0.886
MITF-M-regulated melanocyte development	R-HSA-9730414	0.117537	0.930
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	0.140000	0.854
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	0.189108	0.723
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	0.222408	0.653
Inhibition of TSC complex formation by PKB	R-HSA-165181	0.222408	0.653
GRB7 events in ERBB2 signaling	R-HSA-1306955	0.222408	0.653
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	0.222408	0.653
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	0.254341	0.595
NOSIP mediated eNOS trafficking	R-HSA-203754	0.254341	0.595
Nef Mediated CD8 Down-regulation	R-HSA-182218	0.284966	0.545
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	0.284966	0.545
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	0.284966	0.545
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	0.174911	0.757
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	0.174911	0.757
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	0.174911	0.757
PTK6 promotes HIF1A stabilization	R-HSA-8857538	0.314334	0.503
Signaling by LTK in cancer	R-HSA-9842640	0.314334	0.503
Erythropoietin activates STAT5	R-HSA-9027283	0.314334	0.503
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	0.314334	0.503
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	0.314334	0.503
ERBB2 Regulates Cell Motility	R-HSA-6785631	0.189884	0.722
Phosphorylation of the APC/C	R-HSA-176412	0.205019	0.688
NOSTRIN mediated eNOS trafficking	R-HSA-203641	0.342498	0.465
IFNG signaling activates MAPKs	R-HSA-9732724	0.342498	0.465
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	0.342498	0.465
Cohesin Loading onto Chromatin	R-HSA-2470946	0.342498	0.465
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	0.342498	0.465
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	0.342498	0.465
Processing of Intronless Pre-mRNAs	R-HSA-77595	0.220278	0.657
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	0.220278	0.657
GRB2 events in ERBB2 signaling	R-HSA-1963640	0.220278	0.657
PI3K events in ERBB2 signaling	R-HSA-1963642	0.235626	0.628
EGFR interacts with phospholipase C-gamma	R-HSA-212718	0.369506	0.432
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	0.369506	0.432
Signaling by ERBB2 ECD mutants	R-HSA-9665348	0.251030	0.600
mRNA Capping	R-HSA-72086	0.182801	0.738
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	0.266459	0.574
Impaired BRCA2 binding to PALB2	R-HSA-9709603	0.266459	0.574
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	0.281885	0.550
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	0.281885	0.550
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	0.281885	0.550
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	0.281885	0.550
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	0.281885	0.550
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	0.420245	0.376
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	0.420245	0.376
Folding of actin by CCT/TriC	R-HSA-390450	0.420245	0.376
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	0.193036	0.714
mRNA Splicing - Minor Pathway	R-HSA-72165	0.193036	0.714
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	0.159869	0.796
RAF activation	R-HSA-5673000	0.247606	0.606
Dual Incision in GG-NER	R-HSA-5696400	0.247606	0.606
RNA Polymerase II Transcription Termination	R-HSA-73856	0.166594	0.778
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	0.327900	0.484
Signaling by APC mutants	R-HSA-4839744	0.444064	0.353
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	0.444064	0.353
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	0.444064	0.353
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	0.444064	0.353
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	0.180368	0.744
Loss of Nlp from mitotic centrosomes	R-HSA-380259	0.180368	0.744
Regulation of RAS by GAPs	R-HSA-5658442	0.227612	0.643
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	0.343078	0.465
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	0.343078	0.465
AURKA Activation by TPX2	R-HSA-8854518	0.201782	0.695
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	0.245453	0.610
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	0.358145	0.446
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	0.358145	0.446
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	0.466906	0.331
Activation of RAC1	R-HSA-428540	0.466906	0.331
Signaling by GSK3beta mutants	R-HSA-5339716	0.466906	0.331
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	0.254488	0.594
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	0.254488	0.594
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	0.373083	0.428
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	0.272750	0.564
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	0.281965	0.550
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	0.387879	0.411
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	0.224821	0.648
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	0.254667	0.594
Centrosome maturation	R-HSA-380287	0.270373	0.568
Signaling by ERBB2 KD Mutants	R-HSA-9664565	0.431281	0.365
Impaired BRCA2 binding to RAD51	R-HSA-9709570	0.431281	0.365
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	0.383179	0.417
Nucleosome assembly	R-HSA-774815	0.383179	0.417
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	0.394392	0.404
Signaling by ERBB2 in Cancer	R-HSA-1227990	0.445384	0.351
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	0.405550	0.392
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	0.403753	0.394
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	0.413077	0.384
RNA Polymerase I Promoter Escape	R-HSA-73772	0.460290	0.337
RNA Polymerase III Transcription Initiation	R-HSA-76046	0.445384	0.351
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	0.394402	0.404
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	0.192358	0.716
Activation of the pre-replicative complex	R-HSA-68962	0.445384	0.351
Degradation of beta-catenin by the destruction complex	R-HSA-195253	0.231561	0.635
EGFR downregulation	R-HSA-182971	0.459290	0.338
Signaling by EGFR	R-HSA-177929	0.281965	0.550
Frs2-mediated activation	R-HSA-170968	0.160143	0.795
SHC1 events in ERBB2 signaling	R-HSA-1250196	0.193286	0.714
GAB1 signalosome	R-HSA-180292	0.251030	0.600
VxPx cargo-targeting to cilium	R-HSA-5620916	0.281885	0.550
LGI-ADAM interactions	R-HSA-5682910	0.444064	0.353
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	0.444064	0.353
Recycling pathway of L1	R-HSA-437239	0.201524	0.696
Regulation of mitotic cell cycle	R-HSA-453276	0.239197	0.621
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	0.239197	0.621
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	0.269967	0.569
Processing of DNA double-strand break ends	R-HSA-5693607	0.318564	0.497
RNA Polymerase III Transcription	R-HSA-74158	0.269967	0.569
Regulation of gap junction activity	R-HSA-191650	0.222408	0.653
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	0.254341	0.595
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	0.254341	0.595
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	0.284966	0.545
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	0.369506	0.432
E2F mediated regulation of DNA replication	R-HSA-113510	0.266459	0.574
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	0.395407	0.403
RNA Polymerase I Transcription Termination	R-HSA-73863	0.402519	0.395
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	0.352469	0.453
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	0.465390	0.332
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	0.235626	0.628
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	0.239197	0.621
Cellular response to starvation	R-HSA-9711097	0.208752	0.680
Cyclin D associated events in G1	R-HSA-69231	0.371921	0.430
G1 Phase	R-HSA-69236	0.371921	0.430
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	0.279612	0.553
Circadian clock	R-HSA-9909396	0.426547	0.370
Prolonged ERK activation events	R-HSA-169893	0.205019	0.688
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	0.235626	0.628
Termination of translesion DNA synthesis	R-HSA-5656169	0.182801	0.738
Calcineurin activates NFAT	R-HSA-2025928	0.395407	0.403
TNFR1-induced proapoptotic signaling	R-HSA-5357786	0.297282	0.527
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	0.466906	0.331
Amino acids regulate mTORC1	R-HSA-9639288	0.254488	0.594
Tight junction interactions	R-HSA-420029	0.373083	0.428
RNA Polymerase I Transcription	R-HSA-73864	0.294299	0.531
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	0.326708	0.486
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	0.205019	0.688
Developmental Lineages of the Mammary Gland	R-HSA-9924644	0.431624	0.365
Homology Directed Repair	R-HSA-5693538	0.318873	0.496
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	0.254341	0.595
Aryl hydrocarbon receptor signalling	R-HSA-8937144	0.284966	0.545
Nef Mediated CD4 Down-regulation	R-HSA-167590	0.342498	0.465
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	0.235626	0.628
Lipophagy	R-HSA-9613354	0.395407	0.403
Cyclin E associated events during G1/S transition	R-HSA-69202	0.231561	0.635
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	0.387879	0.411
RNA Polymerase I Promoter Clearance	R-HSA-73854	0.278304	0.555
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	0.192358	0.716
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	0.246900	0.607
Adipogenesis	R-HSA-9843745	0.419801	0.377
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	0.326589	0.486
Downregulation of ERBB2 signaling	R-HSA-8863795	0.445384	0.351
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	0.345029	0.462
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	0.189108	0.723
MET interacts with TNS proteins	R-HSA-8875513	0.189108	0.723
Dopamine receptors	R-HSA-390651	0.222408	0.653
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	0.254341	0.595
CDC6 association with the ORC:origin complex	R-HSA-68689	0.284966	0.545
Synthesis of PS	R-HSA-1483101	0.284966	0.545
Activated NTRK2 signals through CDK5	R-HSA-9032845	0.342498	0.465
Sodium/Proton exchangers	R-HSA-425986	0.369506	0.432
EGFR Transactivation by Gastrin	R-HSA-2179392	0.420245	0.376
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	0.420245	0.376
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	0.420245	0.376
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	0.180368	0.744
Signaling by AXIN mutants	R-HSA-4839735	0.466906	0.331
Signaling by AMER1 mutants	R-HSA-4839748	0.466906	0.331
Switching of origins to a post-replicative state	R-HSA-69052	0.254667	0.594
Interaction between L1 and Ankyrins	R-HSA-445095	0.402519	0.395
Deadenylation-dependent mRNA decay	R-HSA-429914	0.309861	0.509
COPI-mediated anterograde transport	R-HSA-6807878	0.294248	0.531
Chromosome Maintenance	R-HSA-73886	0.338858	0.470
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	0.389343	0.410
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	0.441249	0.355
HCMV Infection	R-HSA-9609646	0.345873	0.461
Signaling by FGFR2	R-HSA-5654738	0.310445	0.508
Assembly of the pre-replicative complex	R-HSA-68867	0.433142	0.363
Aggrephagy	R-HSA-9646399	0.315227	0.501
RAF/MAP kinase cascade	R-HSA-5673001	0.230460	0.637
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	0.300526	0.522
Signaling by FGFR1 in disease	R-HSA-5655302	0.337949	0.471
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	0.343078	0.465
Synthesis of DNA	R-HSA-69239	0.381961	0.418
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	0.258754	0.587
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	0.251030	0.600
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	0.281885	0.550
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	0.338005	0.471
MAPK1/MAPK3 signaling	R-HSA-5684996	0.256951	0.590
Negative regulation of MAPK pathway	R-HSA-5675221	0.337949	0.471
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	0.302355	0.519
Activated NTRK3 signals through PI3K	R-HSA-9603381	0.342498	0.465
Downregulation of ERBB4 signaling	R-HSA-1253288	0.369506	0.432
Activation of the AP-1 family of transcription factors	R-HSA-450341	0.395407	0.403
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	0.395407	0.403
MET activates RAP1 and RAC1	R-HSA-8875555	0.420245	0.376
HATs acetylate histones	R-HSA-3214847	0.182787	0.738
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	0.402519	0.395
Degradation of CDH1	R-HSA-9766229	0.427675	0.369
Negative regulation of the PI3K/AKT network	R-HSA-199418	0.406289	0.391
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	0.420152	0.377
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	0.201782	0.695
G1/S Transition	R-HSA-69206	0.372488	0.429
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	0.167796	0.775
TGFBR3 expression	R-HSA-9839394	0.373083	0.428
Mitotic G1 phase and G1/S transition	R-HSA-453279	0.155944	0.807
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	0.465390	0.332
Negative regulation of FGFR3 signaling	R-HSA-5654732	0.416990	0.380
Negative regulation of FGFR4 signaling	R-HSA-5654733	0.431281	0.365
Sensory perception of sour taste	R-HSA-9729555	0.222408	0.653
Signalling to p38 via RIT and RIN	R-HSA-187706	0.284966	0.545
VLDL clearance	R-HSA-8964046	0.342498	0.465
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	0.369506	0.432
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	0.369506	0.432
ARMS-mediated activation	R-HSA-170984	0.395407	0.403
Synthesis of PI	R-HSA-1483226	0.444064	0.353
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	0.466906	0.331
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	0.338005	0.471
Autophagy	R-HSA-9612973	0.309400	0.509
ER to Golgi Anterograde Transport	R-HSA-199977	0.388768	0.410
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	0.420103	0.377
p53-Dependent G1 DNA Damage Response	R-HSA-69563	0.218819	0.660
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	0.218819	0.660
HCMV Late Events	R-HSA-9610379	0.315098	0.502
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	0.416647	0.380
Carnitine shuttle	R-HSA-200425	0.343078	0.465
Gap junction trafficking and regulation	R-HSA-157858	0.427675	0.369
Regulation of NFE2L2 gene expression	R-HSA-9818749	0.314334	0.503
Signaling by FGFR2 in disease	R-HSA-5655253	0.227612	0.643
Macroautophagy	R-HSA-1632852	0.345029	0.462
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	0.196268	0.707
Sphingolipid de novo biosynthesis	R-HSA-1660661	0.319223	0.496
Reproduction	R-HSA-1474165	0.272133	0.565
Selective autophagy	R-HSA-9663891	0.384096	0.416
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	0.319223	0.496
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	0.254341	0.595
NADPH regeneration	R-HSA-389542	0.314334	0.503
Alpha-defensins	R-HSA-1462054	0.369506	0.432
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	0.420245	0.376
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	0.201524	0.696
Bicarbonate transporters	R-HSA-425381	0.444064	0.353
FLT3 signaling in disease	R-HSA-9682385	0.269967	0.569
Ub-specific processing proteases	R-HSA-5689880	0.288657	0.540
G1/S DNA Damage Checkpoints	R-HSA-69615	0.347413	0.459
ESR-mediated signaling	R-HSA-8939211	0.393415	0.405
Transcriptional regulation by RUNX2	R-HSA-8878166	0.199127	0.701
Sema4D in semaphorin signaling	R-HSA-400685	0.373083	0.428
Signaling by TGF-beta Receptor Complex	R-HSA-170834	0.171796	0.765
PKMTs methylate histone lysines	R-HSA-3214841	0.326589	0.486
G2/M Transition	R-HSA-69275	0.358807	0.445
GP1b-IX-V activation signalling	R-HSA-430116	0.395407	0.403
Plasma lipoprotein clearance	R-HSA-8964043	0.303873	0.517
Potential therapeutics for SARS	R-HSA-9679191	0.275761	0.559
Mitotic G2-G2/M phases	R-HSA-453274	0.369836	0.432
Deubiquitination	R-HSA-5688426	0.185228	0.732
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	0.326589	0.486
Signaling by NTRK2 (TRKB)	R-HSA-9006115	0.402519	0.395
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	0.284966	0.545
Formation of the anterior neural plate	R-HSA-9823739	0.189884	0.722
Uptake and function of diphtheria toxin	R-HSA-5336415	0.342498	0.465
Respiratory syncytial virus genome replication	R-HSA-9834752	0.395407	0.403
Heme signaling	R-HSA-9707616	0.173428	0.761
LDL clearance	R-HSA-8964038	0.327900	0.484
Synthesis of PIPs at the ER membrane	R-HSA-1483248	0.444064	0.353
MAPK6/MAPK4 signaling	R-HSA-5687128	0.198703	0.702
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	0.246900	0.607
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	0.402519	0.395
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	0.189884	0.722
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	0.459290	0.338
Signaling by PDGFR in disease	R-HSA-9671555	0.312628	0.505
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	0.427675	0.369
PI3K Cascade	R-HSA-109704	0.438630	0.358
Neurexins and neuroligins	R-HSA-6794361	0.460290	0.337
TNF signaling	R-HSA-75893	0.281965	0.550
Transcriptional Regulation by VENTX	R-HSA-8853884	0.326589	0.486
Sensory processing of sound	R-HSA-9659379	0.302355	0.519
MHC class II antigen presentation	R-HSA-2132295	0.352272	0.453
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	0.314334	0.503
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	0.220278	0.657
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	0.395407	0.403
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	0.216510	0.665
NRAGE signals death through JNK	R-HSA-193648	0.281965	0.550
Neurodegenerative Diseases	R-HSA-8863678	0.358145	0.446
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	0.358145	0.446
RMTs methylate histone arginines	R-HSA-3214858	0.371921	0.430
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	0.466906	0.331
Interferon Signaling	R-HSA-913531	0.429608	0.367
Displacement of DNA glycosylase by APEX1	R-HSA-110357	0.342498	0.465
RET signaling	R-HSA-8853659	0.269967	0.569
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	0.281965	0.550
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	0.402519	0.395
Regulation of TP53 Activity	R-HSA-5633007	0.218211	0.661
Regulation of TNFR1 signaling	R-HSA-5357905	0.193036	0.714
SARS-CoV-2-host interactions	R-HSA-9705683	0.246066	0.609
G0 and Early G1	R-HSA-1538133	0.214677	0.668
Transport of RCbl within the body	R-HSA-9758890	0.444064	0.353
CD28 dependent PI3K/Akt signaling	R-HSA-389357	0.402519	0.395
KEAP1-NFE2L2 pathway	R-HSA-9755511	0.177080	0.752
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	0.327900	0.484
Uptake and function of anthrax toxins	R-HSA-5210891	0.235626	0.628
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	0.395407	0.403
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	0.312628	0.505
SLC-mediated transport of inorganic anions	R-HSA-9958790	0.292538	0.534
Death Receptor Signaling	R-HSA-73887	0.298077	0.526
Netrin-1 signaling	R-HSA-373752	0.176415	0.753
DCC mediated attractive signaling	R-HSA-418885	0.189884	0.722
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	0.358145	0.446
Apoptosis	R-HSA-109581	0.227838	0.642
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	0.327900	0.484
Interleukin-37 signaling	R-HSA-9008059	0.445384	0.351
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	0.440840	0.356
SARS-CoV Infections	R-HSA-9679506	0.457936	0.339
FGFR2 mutant receptor activation	R-HSA-1839126	0.269967	0.569
Unfolded Protein Response (UPR)	R-HSA-381119	0.212245	0.673
SLC transporter disorders	R-HSA-5619102	0.252586	0.598
Uptake and actions of bacterial toxins	R-HSA-5339562	0.460290	0.337
Interleukin-7 signaling	R-HSA-1266695	0.373083	0.428
Growth hormone receptor signaling	R-HSA-982772	0.343078	0.465
Signaling by NOTCH1	R-HSA-1980143	0.468203	0.330
Programmed Cell Death	R-HSA-5357801	0.469645	0.328
Signaling by TGFB family members	R-HSA-9006936	0.470068	0.328
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	0.470985	0.327
Regulation of PTEN stability and activity	R-HSA-8948751	0.470985	0.327
Meiotic synapsis	R-HSA-1221632	0.470985	0.327
TCF dependent signaling in response to WNT	R-HSA-201681	0.472809	0.325
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	0.472990	0.325
SARS-CoV-2 Infection	R-HSA-9694516	0.480247	0.319
Signaling by FGFR	R-HSA-190236	0.481309	0.318
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	0.481583	0.317
G alpha (12/13) signalling events	R-HSA-416482	0.486172	0.313
Integrin signaling	R-HSA-354192	0.486478	0.313
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	0.486478	0.313
Negative regulation of FGFR1 signaling	R-HSA-5654726	0.486478	0.313
FGFR1 mutant receptor activation	R-HSA-1839124	0.486478	0.313
Activation of ATR in response to replication stress	R-HSA-176187	0.486478	0.313
Regulation of MECP2 expression and activity	R-HSA-9022692	0.486478	0.313
FCGR3A-mediated phagocytosis	R-HSA-9664422	0.486647	0.313
Leishmania phagocytosis	R-HSA-9664417	0.486647	0.313
Parasite infection	R-HSA-9664407	0.486647	0.313
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	0.488811	0.311
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	0.488811	0.311
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	0.488811	0.311
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	0.488811	0.311
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	0.488811	0.311
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	0.488811	0.311
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	0.488811	0.311
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	0.488811	0.311
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	0.488811	0.311
GRB2 events in EGFR signaling	R-HSA-179812	0.488811	0.311
Serotonin clearance from the synaptic cleft	R-HSA-380615	0.488811	0.311
Signaling by LTK	R-HSA-9842663	0.488811	0.311
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	0.488811	0.311
Polymerase switching	R-HSA-69091	0.488811	0.311
Leading Strand Synthesis	R-HSA-69109	0.488811	0.311
MET activates RAS signaling	R-HSA-8851805	0.488811	0.311
OAS antiviral response	R-HSA-8983711	0.488811	0.311
p75NTR recruits signalling complexes	R-HSA-209543	0.488811	0.311
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	0.488811	0.311
p75 NTR receptor-mediated signalling	R-HSA-193704	0.489209	0.311
HDACs deacetylate histones	R-HSA-3214815	0.492079	0.308
Paracetamol ADME	R-HSA-9753281	0.492079	0.308
Nuclear events mediated by NFE2L2	R-HSA-9759194	0.498567	0.302
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	0.499679	0.301
Resolution of D-Loop Structures	R-HSA-5693537	0.499750	0.301
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	0.499750	0.301
Effects of PIP2 hydrolysis	R-HSA-114508	0.499750	0.301
Miscellaneous transport and binding events	R-HSA-5223345	0.499750	0.301
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	0.499750	0.301
Formation of axial mesoderm	R-HSA-9796292	0.509817	0.293
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	0.509817	0.293
PI5P Regulates TP53 Acetylation	R-HSA-6811555	0.509817	0.293
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	0.509817	0.293
Replication of the SARS-CoV-1 genome	R-HSA-9682706	0.509817	0.293
Oxidative Stress Induced Senescence	R-HSA-2559580	0.512635	0.290
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	0.512693	0.290
IRS-mediated signalling	R-HSA-112399	0.512751	0.290
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	0.512798	0.290
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	0.512798	0.290
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	0.512798	0.290
Negative regulation of FGFR2 signaling	R-HSA-5654727	0.512798	0.290
Cilium Assembly	R-HSA-5617833	0.513109	0.290
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	0.525621	0.279
Regulation of Apoptosis	R-HSA-169911	0.525621	0.279
Signalling to ERKs	R-HSA-187687	0.525621	0.279
Oncogene Induced Senescence	R-HSA-2559585	0.525621	0.279
Removal of the Flap Intermediate	R-HSA-69166	0.529961	0.276
Retrograde neurotrophin signalling	R-HSA-177504	0.529961	0.276
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	0.529961	0.276
Signaling by FGFR4 in disease	R-HSA-5655291	0.529961	0.276
Signal regulatory protein family interactions	R-HSA-391160	0.529961	0.276
CRMPs in Sema3A signaling	R-HSA-399956	0.529961	0.276
Physiological factors	R-HSA-5578768	0.529961	0.276
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	0.529961	0.276
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	0.532967	0.273
tRNA processing	R-HSA-72306	0.536929	0.270
HSF1 activation	R-HSA-3371511	0.538213	0.269
Regulation of TP53 Degradation	R-HSA-6804757	0.538213	0.269
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	0.538485	0.269
Developmental Biology	R-HSA-1266738	0.540679	0.267
Signaling by ERBB2	R-HSA-1227986	0.542896	0.265
Kinesins	R-HSA-983189	0.542896	0.265
Meiosis	R-HSA-1500620	0.546942	0.262
Protein-protein interactions at synapses	R-HSA-6794362	0.546942	0.262
G2/M Checkpoints	R-HSA-69481	0.547313	0.262
Erythropoietin activates RAS	R-HSA-9027284	0.549279	0.260
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	0.549279	0.260
SHC1 events in EGFR signaling	R-HSA-180336	0.549279	0.260
Beta-catenin phosphorylation cascade	R-HSA-196299	0.549279	0.260
Processive synthesis on the lagging strand	R-HSA-69183	0.549279	0.260
Lysosphingolipid and LPA receptors	R-HSA-419408	0.549279	0.260
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	0.549279	0.260
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	0.549279	0.260
FASTK family proteins regulate processing and stability of mitochondrial RNAs	R-HSA-9837092	0.549279	0.260
IRF3-mediated induction of type I IFN	R-HSA-3270619	0.549279	0.260
Spry regulation of FGF signaling	R-HSA-1295596	0.549279	0.260
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	0.549279	0.260
p75NTR signals via NF-kB	R-HSA-193639	0.549279	0.260
DNA Damage Reversal	R-HSA-73942	0.549279	0.260
Ovarian tumor domain proteases	R-HSA-5689896	0.550573	0.259
IRS-related events triggered by IGF1R	R-HSA-2428928	0.552702	0.258
MAP kinase activation	R-HSA-450294	0.552702	0.258
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	0.562382	0.250
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	0.562698	0.250
MET promotes cell motility	R-HSA-8875878	0.562698	0.250
Disorders of transmembrane transporters	R-HSA-5619115	0.563992	0.249
Stimuli-sensing channels	R-HSA-2672351	0.565448	0.248
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	0.567803	0.246
WNT5A-dependent internalization of FZD4	R-HSA-5099900	0.567803	0.246
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	0.567803	0.246
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	0.567803	0.246
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	0.571933	0.243
Signaling by PTK6	R-HSA-8848021	0.571933	0.243
rRNA modification in the nucleus and cytosol	R-HSA-6790901	0.571933	0.243
DNA Replication Pre-Initiation	R-HSA-69002	0.572754	0.242
Signaling by WNT	R-HSA-195721	0.574073	0.241
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	0.574587	0.241
DNA Double-Strand Break Repair	R-HSA-5693532	0.575904	0.240
IGF1R signaling cascade	R-HSA-2428924	0.581354	0.236
Insulin receptor signalling cascade	R-HSA-74751	0.581354	0.236
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	0.585568	0.232
Acetylcholine regulates insulin secretion	R-HSA-399997	0.585568	0.232
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	0.585568	0.232
Attenuation phase	R-HSA-3371568	0.586238	0.232
Inhibition of DNA recombination at telomere	R-HSA-9670095	0.586238	0.232
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	0.586238	0.232
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	0.586238	0.232
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	0.586238	0.232
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	0.586238	0.232
Mitochondrial tRNA aminoacylation	R-HSA-379726	0.586238	0.232
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	0.590643	0.229
Resolution of Abasic Sites (AP sites)	R-HSA-73933	0.597652	0.224
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	0.602603	0.220
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	0.602603	0.220
Signaling by EGFRvIII in Cancer	R-HSA-5637812	0.602603	0.220
Constitutive Signaling by EGFRvIII	R-HSA-5637810	0.602603	0.220
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	0.602603	0.220
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	0.602603	0.220
Replication of the SARS-CoV-2 genome	R-HSA-9694686	0.602603	0.220
Transcriptional Regulation by MECP2	R-HSA-8986944	0.603759	0.219
HDR through Homologous Recombination (HRR)	R-HSA-5685942	0.608818	0.216
DNA Double Strand Break Response	R-HSA-5693606	0.608818	0.216
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	0.608827	0.216
Degradation of GLI2 by the proteasome	R-HSA-5610783	0.608827	0.216
HIV Transcription Initiation	R-HSA-167161	0.608827	0.216
RNA Polymerase II Transcription Initiation	R-HSA-75953	0.608827	0.216
Degradation of GLI1 by the proteasome	R-HSA-5610780	0.608827	0.216
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	0.611515	0.214
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	0.618939	0.208
G beta:gamma signalling through PLC beta	R-HSA-418217	0.618939	0.208
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	0.618939	0.208
Chaperone Mediated Autophagy	R-HSA-9613829	0.618939	0.208
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	0.618939	0.208
RNA Polymerase III Transcription Termination	R-HSA-73980	0.618939	0.208
Presynaptic function of Kainate receptors	R-HSA-500657	0.618939	0.208
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	0.618939	0.208
Mismatch Repair	R-HSA-5358508	0.618939	0.208
Beta-catenin independent WNT signaling	R-HSA-3858494	0.619247	0.208
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	0.619764	0.208
Neutrophil degranulation	R-HSA-6798695	0.624254	0.205
RNA Polymerase II Promoter Escape	R-HSA-73776	0.630465	0.200
Signaling by FGFR4	R-HSA-5654743	0.630465	0.200
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	0.630465	0.200
PI-3K cascade:FGFR3	R-HSA-5654710	0.634604	0.197
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	0.634604	0.197
The NLRP3 inflammasome	R-HSA-844456	0.634604	0.197
Other interleukin signaling	R-HSA-449836	0.634604	0.197
Regulation of signaling by CBL	R-HSA-912631	0.634604	0.197
STING mediated induction of host immune responses	R-HSA-1834941	0.634604	0.197
Maturation of nucleoprotein	R-HSA-9694631	0.634604	0.197
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	0.634604	0.197
Interleukin-17 signaling	R-HSA-448424	0.635054	0.197
L1CAM interactions	R-HSA-373760	0.635455	0.197
Signaling by Nuclear Receptors	R-HSA-9006931	0.639811	0.194
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	0.640929	0.193
Gap junction trafficking	R-HSA-190828	0.640929	0.193
NoRC negatively regulates rRNA expression	R-HSA-427413	0.643522	0.191
Hedgehog 'on' state	R-HSA-5632684	0.643522	0.191
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	0.648862	0.188
PI-3K cascade:FGFR4	R-HSA-5654720	0.649627	0.187
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	0.649627	0.187
Nephrin family interactions	R-HSA-373753	0.649627	0.187
Protein hydroxylation	R-HSA-9629569	0.649627	0.187
Signal transduction by L1	R-HSA-445144	0.649627	0.187
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	0.651158	0.186
Platelet Aggregation (Plug Formation)	R-HSA-76009	0.651158	0.186
Asymmetric localization of PCP proteins	R-HSA-4608870	0.651158	0.186
Signaling by FGFR3	R-HSA-5654741	0.651158	0.186
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	0.651850	0.186
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	0.659069	0.181
Ca2+ pathway	R-HSA-4086398	0.660038	0.180
Diseases of DNA repair	R-HSA-9675135	0.661154	0.180
Signaling by TGFBR3	R-HSA-9839373	0.661154	0.180
Cellular response to chemical stress	R-HSA-9711123	0.662242	0.179
Telomere Maintenance	R-HSA-157579	0.663116	0.178
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	0.664032	0.178
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	0.664032	0.178
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	0.664032	0.178
Lagging Strand Synthesis	R-HSA-69186	0.664032	0.178
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	0.664032	0.178
Zygotic genome activation (ZGA)	R-HSA-9819196	0.664032	0.178
Basigin interactions	R-HSA-210991	0.664032	0.178
G2/M DNA damage checkpoint	R-HSA-69473	0.668087	0.175
Signaling by ERBB4	R-HSA-1236394	0.668087	0.175
Organelle biogenesis and maintenance	R-HSA-1852241	0.668168	0.175
Phospholipid metabolism	R-HSA-1483257	0.669355	0.174
Protein ubiquitination	R-HSA-8852135	0.675995	0.170
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	0.677846	0.169
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	0.677846	0.169
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	0.677846	0.169
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	0.677846	0.169
FRS-mediated FGFR3 signaling	R-HSA-5654706	0.677846	0.169
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	0.677846	0.169
Listeria monocytogenes entry into host cells	R-HSA-8876384	0.677846	0.169
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	0.677846	0.169
Molybdenum cofactor biosynthesis	R-HSA-947581	0.677846	0.169
Glutathione synthesis and recycling	R-HSA-174403	0.677846	0.169
Signaling by NTRK3 (TRKC)	R-HSA-9034015	0.677846	0.169
Neddylation	R-HSA-8951664	0.680314	0.167
Co-stimulation by CD28	R-HSA-389356	0.680454	0.167
Hedgehog 'off' state	R-HSA-5610787	0.683749	0.165
Regulation of PD-L1(CD274) expression	R-HSA-9909648	0.688852	0.162
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	0.691093	0.160
PI-3K cascade:FGFR1	R-HSA-5654689	0.691093	0.160
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	0.691093	0.160
FRS-mediated FGFR4 signaling	R-HSA-5654712	0.691093	0.160
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	0.691093	0.160
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	0.691093	0.160
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	0.691093	0.160
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	0.691093	0.160
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	0.691393	0.160
Nuclear Receptor transcription pathway	R-HSA-383280	0.698882	0.156
PCP/CE pathway	R-HSA-4086400	0.698882	0.156
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	0.703796	0.153
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	0.703796	0.153
Free fatty acids regulate insulin secretion	R-HSA-400451	0.703796	0.153
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	0.703796	0.153
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	0.703796	0.153
Meiotic recombination	R-HSA-912446	0.707710	0.150
Transport to the Golgi and subsequent modification	R-HSA-948021	0.707805	0.150
Response of endothelial cells to shear stress	R-HSA-9860931	0.709854	0.149
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	0.713446	0.147
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	0.713446	0.147
Signaling by MET	R-HSA-6806834	0.713446	0.147
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	0.715978	0.145
CD209 (DC-SIGN) signaling	R-HSA-5621575	0.715978	0.145
Mitochondrial RNA degradation	R-HSA-9836573	0.715978	0.145
Orc1 removal from chromatin	R-HSA-68949	0.716354	0.145
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	0.716354	0.145
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	0.716354	0.145
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	0.720521	0.142
DNA Replication	R-HSA-69306	0.721629	0.142
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	0.722304	0.141
Golgi Associated Vesicle Biogenesis	R-HSA-432722	0.724782	0.140
PI-3K cascade:FGFR2	R-HSA-5654695	0.727659	0.138
FRS-mediated FGFR1 signaling	R-HSA-5654693	0.727659	0.138
Long-term potentiation	R-HSA-9620244	0.727659	0.138
VEGFR2 mediated cell proliferation	R-HSA-5218921	0.727659	0.138
Polymerase switching on the C-strand of the telomere	R-HSA-174411	0.727659	0.138
MicroRNA (miRNA) biogenesis	R-HSA-203927	0.727659	0.138
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	0.727659	0.138
Glycogen breakdown (glycogenolysis)	R-HSA-70221	0.727659	0.138
Translation initiation complex formation	R-HSA-72649	0.732997	0.135
Signaling by EGFR in Cancer	R-HSA-1643713	0.738860	0.131
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	0.738860	0.131
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	0.738860	0.131
Metalloprotease DUBs	R-HSA-5689901	0.738860	0.131
TRP channels	R-HSA-3295583	0.738860	0.131
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	0.738860	0.131
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	0.738860	0.131
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	0.740229	0.131
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	0.740229	0.131
Ribosomal scanning and start codon recognition	R-HSA-72702	0.748803	0.126
Signaling by FGFR1	R-HSA-5654736	0.748803	0.126
Processive synthesis on the C-strand of the telomere	R-HSA-174414	0.749602	0.125
EPHA-mediated growth cone collapse	R-HSA-3928663	0.749602	0.125
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	0.749602	0.125
Signaling by FGFR3 in disease	R-HSA-5655332	0.749602	0.125
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	0.749602	0.125
Insulin processing	R-HSA-264876	0.749602	0.125
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	0.751684	0.124
MyD88-independent TLR4 cascade	R-HSA-166166	0.751684	0.124
Activation of AMPK downstream of NMDARs	R-HSA-9619483	0.759902	0.119
FRS-mediated FGFR2 signaling	R-HSA-5654700	0.759902	0.119
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	0.759902	0.119
Telomere Extension By Telomerase	R-HSA-171319	0.759902	0.119
Activation of kainate receptors upon glutamate binding	R-HSA-451326	0.759902	0.119
Inflammasomes	R-HSA-622312	0.759902	0.119
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	0.759902	0.119
Iron assimilation using enterobactin	R-HSA-9638334	0.759902	0.119
Pyrimidine salvage	R-HSA-73614	0.759902	0.119
Nonsense-Mediated Decay (NMD)	R-HSA-927802	0.762747	0.118
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	0.762747	0.118
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	0.763798	0.117
Signaling by Erythropoietin	R-HSA-9006335	0.769779	0.114
Downstream signaling of activated FGFR3	R-HSA-5654708	0.769779	0.114
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	0.769779	0.114
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	0.769779	0.114
Extension of Telomeres	R-HSA-180786	0.771000	0.113
Peptide chain elongation	R-HSA-156902	0.772295	0.112
Cellular responses to mechanical stimuli	R-HSA-9855142	0.773424	0.112
Ribosome-associated quality control	R-HSA-9948299	0.777370	0.109
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	0.778010	0.109
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	0.778010	0.109
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	0.778010	0.109
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	0.778010	0.109
Signaling by NOTCH1 in Cancer	R-HSA-2644603	0.778010	0.109
tRNA Aminoacylation	R-HSA-379724	0.778010	0.109
Downstream signaling of activated FGFR4	R-HSA-5654716	0.779250	0.108
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	0.779250	0.108
Neurotransmitter clearance	R-HSA-112311	0.779250	0.108
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	0.779250	0.108
PLC beta mediated events	R-HSA-112043	0.784832	0.105
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	0.788332	0.103
Trafficking of AMPA receptors	R-HSA-399719	0.788332	0.103
Budding and maturation of HIV virion	R-HSA-162588	0.788332	0.103
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	0.788332	0.103
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	0.788332	0.103
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	0.788332	0.103
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	0.789577	0.103
Eukaryotic Translation Initiation	R-HSA-72613	0.793638	0.100
Cap-dependent Translation Initiation	R-HSA-72737	0.793638	0.100
Signaling by WNT in cancer	R-HSA-4791275	0.797041	0.099
DNA strand elongation	R-HSA-69190	0.797041	0.099
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	0.797041	0.099
Inwardly rectifying K+ channels	R-HSA-1296065	0.797041	0.099
Viral Infection Pathways	R-HSA-9824446	0.798101	0.098
Class I MHC mediated antigen processing & presentation	R-HSA-983169	0.798135	0.098
Mitochondrial biogenesis	R-HSA-1592230	0.798460	0.098
Eukaryotic Translation Elongation	R-HSA-156842	0.800483	0.097
Signaling by Insulin receptor	R-HSA-74752	0.800483	0.097
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	0.800483	0.097
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	0.804201	0.095
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	0.805393	0.094
Assembly of the ORC complex at the origin of replication	R-HSA-68616	0.805393	0.094
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	0.805393	0.094
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	0.805393	0.094
G-protein beta:gamma signalling	R-HSA-397795	0.805393	0.094
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	0.805393	0.094
Co-inhibition by PD-1	R-HSA-389948	0.810987	0.091
Vpu mediated degradation of CD4	R-HSA-180534	0.813401	0.090
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	0.813401	0.090
Heme degradation	R-HSA-189483	0.813401	0.090
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	0.815950	0.088
Regulation of T cell activation by CD28 family	R-HSA-388841	0.816996	0.088
Formation of a pool of free 40S subunits	R-HSA-72689	0.820875	0.086
Eukaryotic Translation Termination	R-HSA-72764	0.820875	0.086
NPAS4 regulates expression of target genes	R-HSA-9768919	0.821080	0.086
eNOS activation	R-HSA-203615	0.821080	0.086
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	0.821080	0.086
Mitophagy	R-HSA-5205647	0.821080	0.086
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	0.821080	0.086
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	0.821080	0.086
NOD1/2 Signaling Pathway	R-HSA-168638	0.821080	0.086
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	0.821080	0.086
G-protein mediated events	R-HSA-112040	0.822006	0.085
Maternal to zygotic transition (MZT)	R-HSA-9816359	0.825503	0.083
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	0.827610	0.082
Downstream signaling of activated FGFR2	R-HSA-5654696	0.828443	0.082
Downstream signaling of activated FGFR1	R-HSA-5654687	0.828443	0.082
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	0.828443	0.082
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	0.828443	0.082
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	0.828443	0.082
PERK regulates gene expression	R-HSA-381042	0.828443	0.082
Formation of the cornified envelope	R-HSA-6809371	0.829706	0.081
MyD88 cascade initiated on plasma membrane	R-HSA-975871	0.834981	0.078
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	0.834981	0.078
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	0.834981	0.078
Lysosome Vesicle Biogenesis	R-HSA-432720	0.835504	0.078
Vif-mediated degradation of APOBEC3G	R-HSA-180585	0.835504	0.078
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	0.835504	0.078
Calmodulin induced events	R-HSA-111933	0.835504	0.078
CaM pathway	R-HSA-111997	0.835504	0.078
Developmental Cell Lineages	R-HSA-9734767	0.838111	0.077
COPII-mediated vesicle transport	R-HSA-204005	0.838344	0.077
Fatty acyl-CoA biosynthesis	R-HSA-75105	0.838344	0.077
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	0.838344	0.077
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	0.838344	0.077
FOXO-mediated transcription	R-HSA-9614085	0.839466	0.076
Degradation of DVL	R-HSA-4641258	0.842275	0.075
Degradation of AXIN	R-HSA-4641257	0.842275	0.075
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	0.842275	0.075
SLC-mediated transport of organic cations	R-HSA-549127	0.842275	0.075
Cargo trafficking to the periciliary membrane	R-HSA-5620920	0.843481	0.074
Metabolism of cofactors	R-HSA-8978934	0.843481	0.074
ABC-family proteins mediated transport	R-HSA-382556	0.843845	0.074
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	0.846737	0.072
Selenocysteine synthesis	R-HSA-2408557	0.848120	0.072
trans-Golgi Network Vesicle Budding	R-HSA-199992	0.848470	0.071
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	0.848767	0.071
PPARA activates gene expression	R-HSA-1989781	0.850193	0.070
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	0.854993	0.068
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	0.854993	0.068
Stabilization of p53	R-HSA-69541	0.854993	0.068
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	0.854993	0.068
Viral mRNA Translation	R-HSA-192823	0.856366	0.067
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	0.856913	0.067
Negative regulation of NOTCH4 signaling	R-HSA-9604323	0.860962	0.065
Regulation of RUNX3 expression and activity	R-HSA-8941858	0.860962	0.065
Nuclear signaling by ERBB4	R-HSA-1251985	0.860962	0.065
Generation of second messenger molecules	R-HSA-202433	0.860962	0.065
Glycogen metabolism	R-HSA-8982491	0.860962	0.065
Non-integrin membrane-ECM interactions	R-HSA-3000171	0.862579	0.064
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	0.862579	0.064
Hh mutants are degraded by ERAD	R-HSA-5362768	0.866687	0.062
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	0.866687	0.062
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	0.866687	0.062
Maturation of spike protein	R-HSA-9694548	0.866687	0.062
Aflatoxin activation and detoxification	R-HSA-5423646	0.866687	0.062
UCH proteinases	R-HSA-5689603	0.867009	0.062
Translation of Structural Proteins	R-HSA-9694635	0.871307	0.060
SARS-CoV-1-host interactions	R-HSA-9692914	0.871691	0.060
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	0.872175	0.059
Intra-Golgi traffic	R-HSA-6811438	0.872175	0.059
Degradation of CRY and PER proteins	R-HSA-9932298	0.872175	0.059
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	0.872175	0.059
SLC-mediated transport of neurotransmitters	R-HSA-442660	0.872175	0.059
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	0.872175	0.059
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	0.875289	0.058
Cholesterol biosynthesis	R-HSA-191273	0.875476	0.058
Interleukin-10 signaling	R-HSA-6783783	0.875476	0.058
Cleavage of the damaged pyrimidine	R-HSA-110329	0.877439	0.057
Depyrimidination	R-HSA-73928	0.877439	0.057
Ca-dependent events	R-HSA-111996	0.877439	0.057
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	0.877439	0.057
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	0.878797	0.056
MyD88 dependent cascade initiated on endosome	R-HSA-975155	0.882218	0.054
Defensins	R-HSA-1461973	0.882485	0.054
Hh mutants abrogate ligand secretion	R-HSA-5387390	0.882485	0.054
Signaling by SCF-KIT	R-HSA-1433557	0.882485	0.054
Integration of energy metabolism	R-HSA-163685	0.883222	0.054
TCR signaling	R-HSA-202403	0.885552	0.053
Amyloid fiber formation	R-HSA-977225	0.887250	0.052
Proteasome assembly	R-HSA-9907900	0.887325	0.052
Amine ligand-binding receptors	R-HSA-375280	0.887325	0.052
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	0.887325	0.052
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	0.887325	0.052
Signaling by Hedgehog	R-HSA-5358351	0.889122	0.051
Fanconi Anemia Pathway	R-HSA-6783310	0.891965	0.050
Defective CFTR causes cystic fibrosis	R-HSA-5678895	0.891965	0.050
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	0.891965	0.050
DAG and IP3 signaling	R-HSA-1489509	0.891965	0.050
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	0.891965	0.050
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	0.891965	0.050
Somitogenesis	R-HSA-9824272	0.891965	0.050
Cytoprotection by HMOX1	R-HSA-9707564	0.894516	0.048
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	0.895055	0.048
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	0.896414	0.047
Condensation of Prophase Chromosomes	R-HSA-2299718	0.896414	0.047
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	0.896414	0.047
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	0.896414	0.047
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	0.897213	0.047
Adaptive Immune System	R-HSA-1280218	0.901305	0.045
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	0.903844	0.044
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	0.904604	0.044
Intraflagellar transport	R-HSA-5620924	0.904772	0.043
Metal ion SLC transporters	R-HSA-425410	0.904772	0.043
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	0.907761	0.042
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	0.908695	0.042
Post NMDA receptor activation events	R-HSA-438064	0.910820	0.041
Azathioprine ADME	R-HSA-9748787	0.912456	0.040
Diseases of programmed cell death	R-HSA-9645723	0.913784	0.039
Activation of NF-kappaB in B cells	R-HSA-1169091	0.916063	0.038
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	0.916063	0.038
Hedgehog ligand biogenesis	R-HSA-5358346	0.916063	0.038
ER-Phagosome pathway	R-HSA-1236974	0.916656	0.038
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	0.917024	0.038
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	0.917024	0.038
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	0.917127	0.038
Signaling by NOTCH	R-HSA-157118	0.918826	0.037
Gastrulation	R-HSA-9758941	0.919330	0.037
Class B/2 (Secretin family receptors)	R-HSA-373080	0.919437	0.036
Base Excision Repair	R-HSA-73884	0.919437	0.036
Downstream TCR signaling	R-HSA-202424	0.919437	0.036
Transcriptional Regulation by NPAS4	R-HSA-9634815	0.919521	0.036
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	0.919521	0.036
Smooth Muscle Contraction	R-HSA-445355	0.922837	0.035
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	0.924120	0.034
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	0.924120	0.034
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	0.925628	0.034
Interleukin-1 family signaling	R-HSA-446652	0.925628	0.034
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	0.926016	0.033
Base-Excision Repair, AP Site Formation	R-HSA-73929	0.926016	0.033
Late SARS-CoV-2 Infection Events	R-HSA-9772573	0.927267	0.033
Cytokine Signaling in Immune system	R-HSA-1280215	0.928412	0.032
G alpha (z) signalling events	R-HSA-418597	0.929065	0.032
Signaling by NOTCH3	R-HSA-9012852	0.929065	0.032
rRNA processing in the nucleus and cytosol	R-HSA-8868773	0.934321	0.030
Leishmania infection	R-HSA-9658195	0.935962	0.029
Parasitic Infection Pathways	R-HSA-9824443	0.935962	0.029
Ion channel transport	R-HSA-983712	0.935979	0.029
Signaling by Interleukins	R-HSA-449147	0.937026	0.028
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	0.937479	0.028
Early SARS-CoV-2 Infection Events	R-HSA-9772572	0.937479	0.028
Interferon gamma signaling	R-HSA-877300	0.938636	0.028
CLEC7A (Dectin-1) signaling	R-HSA-5607764	0.938741	0.027
RAB geranylgeranylation	R-HSA-8873719	0.942527	0.026
Glutathione conjugation	R-HSA-156590	0.942527	0.026
Metabolism of polyamines	R-HSA-351202	0.942527	0.026
Regulation of RUNX2 expression and activity	R-HSA-8939902	0.944896	0.025
Nucleotide salvage	R-HSA-8956321	0.944896	0.025
Formation of paraxial mesoderm	R-HSA-9793380	0.944896	0.025
Collagen degradation	R-HSA-1442490	0.944896	0.025
Extra-nuclear estrogen signaling	R-HSA-9009391	0.948485	0.023
Interleukin-1 signaling	R-HSA-9020702	0.948485	0.023
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	0.950247	0.022
Cellular response to hypoxia	R-HSA-1234174	0.953437	0.021
Opioid Signalling	R-HSA-111885	0.953602	0.021
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	0.956220	0.019
Antigen processing-Cross presentation	R-HSA-1236975	0.961068	0.017
SARS-CoV-1 Infection	R-HSA-9678108	0.962060	0.017
Post-translational protein modification	R-HSA-597592	0.963391	0.016
Metal ion assimilation from the host	R-HSA-9638482	0.963834	0.016
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	0.963834	0.016
Metabolism of porphyrins	R-HSA-189445	0.963834	0.016
Signaling by NOTCH4	R-HSA-9013694	0.968128	0.014
ROS and RNS production in phagocytes	R-HSA-1222556	0.968128	0.014
Citric acid cycle (TCA cycle)	R-HSA-71403	0.969443	0.013
Interferon alpha/beta signaling	R-HSA-909733	0.971700	0.012
SLC-mediated transport of organic anions	R-HSA-9955298	0.973072	0.012
ABC transporter disorders	R-HSA-5619084	0.973072	0.012
PKR-mediated signaling	R-HSA-9833482	0.975249	0.011
Toll-like Receptor Cascades	R-HSA-168898	0.976257	0.010
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	0.978189	0.010
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	0.978248	0.010
rRNA processing	R-HSA-72312	0.980456	0.009
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	0.980932	0.008
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	0.980932	0.008
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	0.980932	0.008
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	0.981574	0.008
Selenoamino acid metabolism	R-HSA-2408522	0.982106	0.008
Chaperonin-mediated protein folding	R-HSA-390466	0.982334	0.008
Sphingolipid metabolism	R-HSA-428157	0.982412	0.008
Neurotransmitter release cycle	R-HSA-112310	0.984434	0.007
Pre-NOTCH Transcription and Translation	R-HSA-1912408	0.985077	0.007
Keratinization	R-HSA-6805567	0.985345	0.006
Degradation of the extracellular matrix	R-HSA-1474228	0.985735	0.006
C-type lectin receptors (CLRs)	R-HSA-5621481	0.986244	0.006
Protein folding	R-HSA-391251	0.986284	0.006
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	0.986851	0.006
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	0.987810	0.005
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	0.987915	0.005
Potassium Channels	R-HSA-1296071	0.988893	0.005
Metabolism of steroids	R-HSA-8957322	0.989621	0.005
Regulation of insulin secretion	R-HSA-422356	0.989792	0.004
Synthesis of bile acids and bile salts	R-HSA-192105	0.990214	0.004
Infectious disease	R-HSA-5663205	0.990845	0.004
FCERI mediated NF-kB activation	R-HSA-2871837	0.991463	0.004
G alpha (q) signalling events	R-HSA-416476	0.992267	0.003
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	0.992403	0.003
Activation of HOX genes during differentiation	R-HSA-5619507	0.992403	0.003
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	0.992403	0.003
RSV-host interactions	R-HSA-9833110	0.992403	0.003
Platelet homeostasis	R-HSA-418346	0.993019	0.003
Disease	R-HSA-1643685	0.993647	0.003
Protein localization	R-HSA-9609507	0.993883	0.003
Bile acid and bile salt metabolism	R-HSA-194068	0.994104	0.003
Platelet activation, signaling and aggregation	R-HSA-76002	0.994265	0.002
Antimicrobial peptides	R-HSA-6803157	0.994348	0.002
FCERI mediated MAPK activation	R-HSA-2871796	0.994581	0.002
Pre-NOTCH Expression and Processing	R-HSA-1912422	0.994805	0.002
Immune System	R-HSA-168256	0.994814	0.002
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	0.995323	0.002
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	0.995337	0.002
Asparagine N-linked glycosylation	R-HSA-446203	0.995403	0.002
Role of phospholipids in phagocytosis	R-HSA-2029485	0.995613	0.002
Peptide hormone metabolism	R-HSA-2980736	0.995969	0.002
Transmission across Chemical Synapses	R-HSA-112315	0.996003	0.002
Neuronal System	R-HSA-112316	0.996644	0.001
G alpha (s) signalling events	R-HSA-418555	0.996996	0.001
Drug ADME	R-HSA-9748784	0.997311	0.001
Platelet degranulation	R-HSA-114608	0.997468	0.001
Nucleotide catabolism	R-HSA-8956319	0.997673	0.001
Sensory perception of taste	R-HSA-9717189	0.997951	0.001
Cardiac conduction	R-HSA-5576891	0.997951	0.001
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	0.998117	0.001
Hemostasis	R-HSA-109582	0.998161	0.001
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	0.998234	0.001
Peptide ligand-binding receptors	R-HSA-375276	0.998298	0.001
Innate Immune System	R-HSA-168249	0.998399	0.001
Translation	R-HSA-72766	0.998518	0.001
SLC-mediated transmembrane transport	R-HSA-425407	0.998695	0.001
Glycerophospholipid biosynthesis	R-HSA-1483206	0.999111	0.000
Arachidonate metabolism	R-HSA-2142753	0.999226	0.000
Muscle contraction	R-HSA-397014	0.999395	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	0.999668	0.000
Extracellular matrix organization	R-HSA-1474244	0.999760	0.000
Metabolism of nucleotides	R-HSA-15869	0.999761	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	0.999770	0.000
Bacterial Infection Pathways	R-HSA-9824439	0.999865	0.000
Infection with Enterobacteria	R-HSA-9640148	0.999915	0.000
Transport of small molecules	R-HSA-382551	0.999962	0.000
Signaling by GPCR	R-HSA-372790	0.999972	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	0.999975	0.000
Metabolism of proteins	R-HSA-392499	0.999982	0.000
Phase II - Conjugation of compounds	R-HSA-156580	0.999982	0.000
G alpha (i) signalling events	R-HSA-418594	0.999984	0.000
Fatty acid metabolism	R-HSA-8978868	0.999984	0.000
GPCR downstream signalling	R-HSA-388396	0.999986	0.000
Phase I - Functionalization of compounds	R-HSA-211945	0.999997	0.000
GPCR ligand binding	R-HSA-500792	0.999999	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000	0.000
Metabolism of lipids	R-HSA-556833	1.000000	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000	0.000
Biological oxidations	R-HSA-211859	1.000000	0.000
Metabolism	R-HSA-1430728	1.000000	-0.000
Sensory Perception	R-HSA-9709957	1.000000	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Chromatin organization	R-HSA-4839726	7.114254e-11	10.148
Chromatin modifying enzymes	R-HSA-3247509	5.774224e-10	9.239
Cellular response to heat stress	R-HSA-3371556	1.372811e-09	8.862
Cell Cycle	R-HSA-1640170	3.882581e-09	8.411
M Phase	R-HSA-68886	1.080709e-08	7.966
Cellular responses to stress	R-HSA-2262752	1.893542e-08	7.723
Cell Cycle, Mitotic	R-HSA-69278	2.268960e-08	7.644
HATs acetylate histones	R-HSA-3214847	3.739315e-08	7.427
Cellular responses to stimuli	R-HSA-8953897	3.700496e-08	7.432
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	5.681068e-08	7.246
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	3.294332e-07	6.482
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	5.782079e-07	6.238
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	9.156499e-07	6.038
Mitotic Anaphase	R-HSA-68882	9.121493e-07	6.040
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.033211e-06	5.986
Cell Cycle Checkpoints	R-HSA-69620	1.620621e-06	5.790
Estrogen-dependent gene expression	R-HSA-9018519	1.960210e-06	5.708
HSF1-dependent transactivation	R-HSA-3371571	2.085874e-06	5.681
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	2.458107e-06	5.609
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	3.030092e-06	5.519
Transcriptional regulation by small RNAs	R-HSA-5578749	3.098613e-06	5.509
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	3.515167e-06	5.454
Mitotic Prophase	R-HSA-68875	3.465723e-06	5.460
Cellular Senescence	R-HSA-2559583	3.899401e-06	5.409
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	5.766319e-06	5.239
Metabolism of RNA	R-HSA-8953854	6.115192e-06	5.214
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	7.412988e-06	5.130
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.096560e-05	4.960
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.153101e-05	4.938
Signaling by ALK in cancer	R-HSA-9700206	1.153101e-05	4.938
Attenuation phase	R-HSA-3371568	1.197111e-05	4.922
Cell-extracellular matrix interactions	R-HSA-446353	1.598787e-05	4.796
ESR-mediated signaling	R-HSA-8939211	2.006458e-05	4.698
mRNA Splicing - Major Pathway	R-HSA-72163	2.111467e-05	4.675
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	2.290769e-05	4.640
Nuclear Envelope Breakdown	R-HSA-2980766	2.860375e-05	4.544
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	3.199663e-05	4.495
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	3.139619e-05	4.503
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	4.155470e-05	4.381
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	4.379737e-05	4.359
Separation of Sister Chromatids	R-HSA-2467813	4.409351e-05	4.356
Mitotic Spindle Checkpoint	R-HSA-69618	4.771320e-05	4.321
HSF1 activation	R-HSA-3371511	4.981436e-05	4.303
TCF dependent signaling in response to WNT	R-HSA-201681	5.084228e-05	4.294
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	5.150864e-05	4.288
Transport of the SLBP independent Mature mRNA	R-HSA-159227	5.884862e-05	4.230
Vpr-mediated nuclear import of PICs	R-HSA-180910	6.486536e-05	4.188
Epigenetic regulation of gene expression	R-HSA-212165	6.589703e-05	4.181
mRNA Splicing	R-HSA-72172	6.902698e-05	4.161
Apoptotic execution phase	R-HSA-75153	7.009059e-05	4.154
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	7.757955e-05	4.110
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	9.110582e-05	4.040
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	9.128111e-05	4.040
Meiosis	R-HSA-1500620	9.945968e-05	4.002
Nuclear import of Rev protein	R-HSA-180746	1.013242e-04	3.994
DNA Double-Strand Break Repair	R-HSA-5693532	1.076087e-04	3.968
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.208566e-04	3.918
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.208566e-04	3.918
Metabolism of non-coding RNA	R-HSA-194441	1.248415e-04	3.904
snRNP Assembly	R-HSA-191859	1.248415e-04	3.904
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.311690e-04	3.882
Interactions of Rev with host cellular proteins	R-HSA-177243	1.365278e-04	3.865
Interactions of Vpr with host cellular proteins	R-HSA-176033	1.365278e-04	3.865
Cell junction organization	R-HSA-446728	1.425212e-04	3.846
Apoptotic cleavage of cellular proteins	R-HSA-111465	1.583973e-04	3.800
Gene Silencing by RNA	R-HSA-211000	1.535361e-04	3.814
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.615747e-04	3.792
PRC2 methylates histones and DNA	R-HSA-212300	1.683773e-04	3.774
Nucleosome assembly	R-HSA-774815	1.716117e-04	3.765
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	1.716117e-04	3.765
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	1.760113e-04	3.754
IPs transport between nucleus and cytosol	R-HSA-1855170	2.056104e-04	3.687
DNA Double Strand Break Response	R-HSA-5693606	2.020218e-04	3.695
Meiotic recombination	R-HSA-912446	2.049041e-04	3.688
Assembly of the pre-replicative complex	R-HSA-68867	1.930883e-04	3.714
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	2.192053e-04	3.659
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	2.433284e-04	3.614
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	2.498811e-04	3.602
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	2.566227e-04	3.591
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	2.644695e-04	3.578
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	2.707281e-04	3.567
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	2.835461e-04	3.547
Amplification of signal from the kinetochores	R-HSA-141424	2.835461e-04	3.547
Mitotic Prometaphase	R-HSA-68877	2.763074e-04	3.559
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	2.709329e-04	3.567
Eukaryotic Translation Initiation	R-HSA-72613	2.948216e-04	3.530
Cap-dependent Translation Initiation	R-HSA-72737	2.948216e-04	3.530
Meiotic synapsis	R-HSA-1221632	3.032269e-04	3.518
Protein ubiquitination	R-HSA-8852135	3.033801e-04	3.518
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	3.372387e-04	3.472
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	3.372387e-04	3.472
Interleukin-12 signaling	R-HSA-9020591	3.555156e-04	3.449
Homology Directed Repair	R-HSA-5693538	3.770367e-04	3.424
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	3.987552e-04	3.399
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	4.055322e-04	3.392
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	4.233294e-04	3.373
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	4.264953e-04	3.370
DNA Replication Pre-Initiation	R-HSA-69002	4.407292e-04	3.356
Packaging Of Telomere Ends	R-HSA-171306	5.072214e-04	3.295
PKMTs methylate histone lysines	R-HSA-3214841	5.237732e-04	3.281
Ribosomal scanning and start codon recognition	R-HSA-72702	5.268329e-04	3.278
G2/M DNA damage checkpoint	R-HSA-69473	6.324304e-04	3.199
DNA methylation	R-HSA-5334118	8.390886e-04	3.076
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	8.286642e-04	3.082
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	8.390886e-04	3.076
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	8.074822e-04	3.093
Regulation of CDH1 Gene Transcription	R-HSA-9764560	8.273585e-04	3.082
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	8.651971e-04	3.063
Cell-Cell communication	R-HSA-1500931	8.832290e-04	3.054
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	9.339903e-04	3.030
Regulation of CDH1 Expression and Function	R-HSA-9764265	9.339903e-04	3.030
Translation initiation complex formation	R-HSA-72649	9.717433e-04	3.012
ATP-dependent chromatin remodelers	R-HSA-9932444	1.035719e-03	2.985
SWI/SNF chromatin remodelers	R-HSA-9932451	1.035719e-03	2.985
NS1 Mediated Effects on Host Pathways	R-HSA-168276	1.012085e-03	2.995
Cohesin Loading onto Chromatin	R-HSA-2470946	1.119771e-03	2.951
Signal Transduction	R-HSA-162582	1.128887e-03	2.947
G2/M Checkpoints	R-HSA-69481	1.169759e-03	2.932
HIV Life Cycle	R-HSA-162587	1.219803e-03	2.914
Inhibition of DNA recombination at telomere	R-HSA-9670095	1.234840e-03	2.908
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	1.497225e-03	2.825
Processing of DNA double-strand break ends	R-HSA-5693607	1.701862e-03	2.769
RNA Polymerase I Promoter Opening	R-HSA-73728	1.685313e-03	2.773
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	1.655709e-03	2.781
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	1.662095e-03	2.779
ISG15 antiviral mechanism	R-HSA-1169408	1.703675e-03	2.769
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.708030e-03	2.768
Signaling by WNT	R-HSA-195721	1.779936e-03	2.750
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	1.861494e-03	2.730
Influenza Viral RNA Transcription and Replication	R-HSA-168273	1.870971e-03	2.728
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	1.909014e-03	2.719
Interleukin-12 family signaling	R-HSA-447115	1.912160e-03	2.718
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.941267e-03	2.712
Assembly of the ORC complex at the origin of replication	R-HSA-68616	2.052121e-03	2.688
Cleavage of the damaged pyrimidine	R-HSA-110329	2.162411e-03	2.665
Depyrimidination	R-HSA-73928	2.162411e-03	2.665
Axon guidance	R-HSA-422475	2.285967e-03	2.641
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	2.604372e-03	2.584
Striated Muscle Contraction	R-HSA-390522	2.514014e-03	2.600
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	2.767789e-03	2.558
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	2.825068e-03	2.549
HIV Infection	R-HSA-162906	2.875906e-03	2.541
Nervous system development	R-HSA-9675108	3.097710e-03	2.509
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	3.266593e-03	2.486
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	3.603100e-03	2.443
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	3.962115e-03	2.402
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	4.012893e-03	2.397
Gene expression (Transcription)	R-HSA-74160	4.042690e-03	2.393
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	4.072091e-03	2.390
Adherens junctions interactions	R-HSA-418990	4.127435e-03	2.384
Signaling by Hippo	R-HSA-2028269	4.150538e-03	2.382
Condensation of Prophase Chromosomes	R-HSA-2299718	4.228859e-03	2.374
Transcriptional regulation by RUNX1	R-HSA-8878171	4.397295e-03	2.357
NoRC negatively regulates rRNA expression	R-HSA-427413	4.945871e-03	2.306
Regulation of PD-L1(CD274) expression	R-HSA-9909648	4.783927e-03	2.320
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	5.005690e-03	2.301
Membrane Trafficking	R-HSA-199991	5.166315e-03	2.287
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	5.252246e-03	2.280
SIRT1 negatively regulates rRNA expression	R-HSA-427359	5.277454e-03	2.278
Cleavage of the damaged purine	R-HSA-110331	5.277454e-03	2.278
Chaperone Mediated Autophagy	R-HSA-9613829	5.375492e-03	2.270
Nuclear Receptor transcription pathway	R-HSA-383280	5.436974e-03	2.265
RNA Polymerase I Transcription	R-HSA-73864	5.436974e-03	2.265
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	5.797105e-03	2.237
S Phase	R-HSA-69242	5.871271e-03	2.231
RNA Polymerase II Transcription Termination	R-HSA-73856	6.611686e-03	2.180
Regulation of endogenous retroelements	R-HSA-9842860	6.273599e-03	2.202
Signaling by Nuclear Receptors	R-HSA-9006931	6.146141e-03	2.211
Late Phase of HIV Life Cycle	R-HSA-162599	6.296035e-03	2.201
MAP kinase activation	R-HSA-450294	6.611686e-03	2.180
Pre-NOTCH Transcription and Translation	R-HSA-1912408	6.274024e-03	2.202
Viral Messenger RNA Synthesis	R-HSA-168325	6.611686e-03	2.180
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	5.979039e-03	2.223
Defective pyroptosis	R-HSA-9710421	6.520429e-03	2.186
Depurination	R-HSA-73927	6.251703e-03	2.204
HDACs deacetylate histones	R-HSA-3214815	6.673173e-03	2.176
Chromosome Maintenance	R-HSA-73886	7.590922e-03	2.120
DNA Repair	R-HSA-73894	7.740404e-03	2.111
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	7.966093e-03	2.099
Mitotic Telophase/Cytokinesis	R-HSA-68884	7.966093e-03	2.099
Influenza Infection	R-HSA-168255	8.049540e-03	2.094
RAF activation	R-HSA-5673000	8.255470e-03	2.083
Activation of HOX genes during differentiation	R-HSA-5619507	8.392131e-03	2.076
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	8.392131e-03	2.076
Semaphorin interactions	R-HSA-373755	8.516947e-03	2.070
Cell-cell junction organization	R-HSA-421270	8.660971e-03	2.062
mRNA 3'-end processing	R-HSA-72187	1.007076e-02	1.997
RNA Polymerase I Promoter Escape	R-HSA-73772	1.007076e-02	1.997
RNA Polymerase I Promoter Clearance	R-HSA-73854	8.931560e-03	2.049
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	1.004637e-02	1.998
Diseases of programmed cell death	R-HSA-9645723	9.032515e-03	2.044
Host Interactions of HIV factors	R-HSA-162909	9.829185e-03	2.007
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	1.013752e-02	1.994
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	1.108311e-02	1.955
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	1.108311e-02	1.955
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	1.108311e-02	1.955
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	1.108311e-02	1.955
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	1.108311e-02	1.955
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	1.108311e-02	1.955
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	1.108311e-02	1.955
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	1.108311e-02	1.955
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	1.108311e-02	1.955
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	1.108311e-02	1.955
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	1.108311e-02	1.955
Formation of a pool of free 40S subunits	R-HSA-72689	1.147104e-02	1.940
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	1.160000e-02	1.936
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	1.160000e-02	1.936
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	1.160000e-02	1.936
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	1.210358e-02	1.917
ERK/MAPK targets	R-HSA-198753	1.072677e-02	1.970
Myogenesis	R-HSA-525793	1.210358e-02	1.917
Clathrin-mediated endocytosis	R-HSA-8856828	1.176358e-02	1.929
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	1.165559e-02	1.933
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	1.106438e-02	1.956
Oxidative Stress Induced Senescence	R-HSA-2559580	1.181267e-02	1.928
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	1.210358e-02	1.917
Regulation of T cell activation by CD28 family	R-HSA-388841	1.159388e-02	1.936
Reproduction	R-HSA-1474165	1.079214e-02	1.967
Circadian clock	R-HSA-9909396	1.264797e-02	1.898
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.269630e-02	1.896
ALK mutants bind TKIs	R-HSA-9700645	1.269630e-02	1.896
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.269630e-02	1.896
Base-Excision Repair, AP Site Formation	R-HSA-73929	1.302707e-02	1.885
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	1.369995e-02	1.863
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	1.376435e-02	1.861
Regulation of TP53 Activity	R-HSA-5633007	1.449267e-02	1.839
DNA Replication	R-HSA-69306	1.460127e-02	1.836
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	1.519390e-02	1.818
tRNA processing in the nucleus	R-HSA-6784531	1.594431e-02	1.797
Deubiquitination	R-HSA-5688426	1.654143e-02	1.781
Apoptosis	R-HSA-109581	1.661923e-02	1.779
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	1.679981e-02	1.775
Depolymerization of the Nuclear Lamina	R-HSA-4419969	1.730528e-02	1.762
EPHB-mediated forward signaling	R-HSA-3928662	1.762392e-02	1.754
Glycolysis	R-HSA-70171	1.804045e-02	1.744
Regulation of CDH1 Function	R-HSA-9764561	1.866870e-02	1.729
Interleukin-17 signaling	R-HSA-448424	1.882890e-02	1.725
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	1.993004e-02	1.700
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	1.993004e-02	1.700
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	1.993004e-02	1.700
CREB phosphorylation	R-HSA-199920	2.020350e-02	1.695
Signaling by APC mutants	R-HSA-4839744	2.289753e-02	1.640
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	2.289753e-02	1.640
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	2.289753e-02	1.640
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	2.289753e-02	1.640
Sema3A PAK dependent Axon repulsion	R-HSA-399954	2.267893e-02	1.644
Regulation of NFE2L2 gene expression	R-HSA-9818749	2.020350e-02	1.695
Co-inhibition by PD-1	R-HSA-389948	1.975037e-02	1.704
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	2.306031e-02	1.637
Base Excision Repair	R-HSA-73884	2.076060e-02	1.683
rRNA processing in the nucleus and cytosol	R-HSA-8868773	2.315451e-02	1.635
Signaling by ROBO receptors	R-HSA-376176	2.351679e-02	1.629
Downregulation of ERBB2 signaling	R-HSA-8863795	2.370001e-02	1.625
RNA Polymerase III Transcription Initiation	R-HSA-76046	2.370001e-02	1.625
Telomere Maintenance	R-HSA-157579	2.501166e-02	1.602
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	2.515799e-02	1.599
MyD88-independent TLR4 cascade	R-HSA-166166	2.520562e-02	1.599
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	2.520562e-02	1.599
Eukaryotic Translation Elongation	R-HSA-156842	2.695059e-02	1.569
TGFBR3 expression	R-HSA-9839394	2.712472e-02	1.567
Sema4D in semaphorin signaling	R-HSA-400685	2.712472e-02	1.567
MyD88 cascade initiated on plasma membrane	R-HSA-975871	2.715037e-02	1.566
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	2.715037e-02	1.566
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	2.715037e-02	1.566
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	2.753574e-02	1.560
Programmed Cell Death	R-HSA-5357801	2.782743e-02	1.556
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	2.812994e-02	1.551
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	2.822868e-02	1.549
MECP2 regulates transcription factors	R-HSA-9022707	2.822868e-02	1.549
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	2.884984e-02	1.540
Nonsense-Mediated Decay (NMD)	R-HSA-927802	2.934999e-02	1.532
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	2.934999e-02	1.532
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	2.944925e-02	1.531
Signaling by GSK3beta mutants	R-HSA-5339716	2.954629e-02	1.529
Signaling by AXIN mutants	R-HSA-4839735	2.954629e-02	1.529
Signaling by AMER1 mutants	R-HSA-4839748	2.954629e-02	1.529
MTOR signalling	R-HSA-165159	3.011743e-02	1.521
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	3.077306e-02	1.512
Peptide chain elongation	R-HSA-156902	3.160379e-02	1.500
Pre-NOTCH Expression and Processing	R-HSA-1912422	3.160611e-02	1.500
GRB7 events in ERBB2 signaling	R-HSA-1306955	3.172450e-02	1.499
Transcriptional regulation of granulopoiesis	R-HSA-9616222	3.193355e-02	1.496
Ribosome-associated quality control	R-HSA-9948299	3.448710e-02	1.462
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	3.614145e-02	1.442
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	3.649200e-02	1.438
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	3.685304e-02	1.434
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	3.685304e-02	1.434
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	3.729821e-02	1.428
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	3.729821e-02	1.428
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	3.729821e-02	1.428
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	3.729821e-02	1.428
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	3.729821e-02	1.428
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	3.729821e-02	1.428
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	4.618698e-02	1.335
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	4.618698e-02	1.335
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	4.618698e-02	1.335
Notch-HLH transcription pathway	R-HSA-350054	4.287026e-02	1.368
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	4.000892e-02	1.398
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	4.261063e-02	1.370
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	4.034485e-02	1.394
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	4.361456e-02	1.360
Oncogenic MAPK signaling	R-HSA-6802957	4.030343e-02	1.395
Resolution of D-Loop Structures	R-HSA-5693537	4.161612e-02	1.381
RUNX3 regulates NOTCH signaling	R-HSA-8941856	3.729821e-02	1.428
Cellular response to hypoxia	R-HSA-1234174	4.261063e-02	1.370
mTORC1-mediated signalling	R-HSA-166208	4.287026e-02	1.368
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	3.697497e-02	1.432
Maternal to zygotic transition (MZT)	R-HSA-9816359	4.413421e-02	1.355
MyD88 dependent cascade initiated on endosome	R-HSA-975155	3.960832e-02	1.402
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	3.790287e-02	1.421
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	3.915747e-02	1.407
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	4.618698e-02	1.335
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	3.811486e-02	1.419
Breakdown of the nuclear lamina	R-HSA-352238	4.621259e-02	1.335
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	4.643107e-02	1.333
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	4.643107e-02	1.333
Switching of origins to a post-replicative state	R-HSA-69052	4.715682e-02	1.326
Signaling by RAS mutants	R-HSA-6802949	4.748572e-02	1.323
Signaling downstream of RAS mutants	R-HSA-9649948	4.748572e-02	1.323
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	4.748572e-02	1.323
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	4.748572e-02	1.323
Golgi Associated Vesicle Biogenesis	R-HSA-432722	4.919734e-02	1.308
Cellular response to mitochondrial stress	R-HSA-9840373	4.925122e-02	1.308
Regulation of PTEN gene transcription	R-HSA-8943724	5.032580e-02	1.298
Kinesins	R-HSA-983189	5.032580e-02	1.298
RNA Polymerase II Pre-transcription Events	R-HSA-674695	5.130216e-02	1.290
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	5.132088e-02	1.290
Signaling by NOTCH	R-HSA-157118	5.141054e-02	1.289
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	5.214929e-02	1.283
HCMV Early Events	R-HSA-9609690	5.369203e-02	1.270
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	5.767877e-02	1.239
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	5.821280e-02	1.235
STING mediated induction of host immune responses	R-HSA-1834941	5.821280e-02	1.235
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	5.988500e-02	1.223
RNA Polymerase III Transcription	R-HSA-74158	5.988500e-02	1.223
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	5.988500e-02	1.223
Heme signaling	R-HSA-9707616	6.022885e-02	1.220
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	6.226429e-02	1.206
Apoptosis induced DNA fragmentation	R-HSA-140342	6.226429e-02	1.206
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	6.284321e-02	1.202
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	6.560178e-02	1.183
Beta-catenin phosphorylation cascade	R-HSA-196299	6.743167e-02	1.171
DCC mediated attractive signaling	R-HSA-418885	6.743167e-02	1.171
IRF3-mediated induction of type I IFN	R-HSA-3270619	6.743167e-02	1.171
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	6.790392e-02	1.168
Co-inhibition by CTLA4	R-HSA-389513	6.790392e-02	1.168
G alpha (12/13) signalling events	R-HSA-416482	7.039577e-02	1.152
Response of endothelial cells to shear stress	R-HSA-9860931	7.044817e-02	1.152
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	7.044817e-02	1.152
Intracellular signaling by second messengers	R-HSA-9006925	7.094425e-02	1.149
HCMV Late Events	R-HSA-9610379	7.121412e-02	1.147
Diseases of mitotic cell cycle	R-HSA-9675126	7.128564e-02	1.147
PIP3 activates AKT signaling	R-HSA-1257604	7.226775e-02	1.141
Glucose metabolism	R-HSA-70326	7.588668e-02	1.120
Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)	R-HSA-1299308	7.637752e-02	1.117
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	7.637752e-02	1.117
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	8.396464e-02	1.076
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	1.063304e-01	0.973
SOS-mediated signalling	R-HSA-112412	1.063304e-01	0.973
Recycling of eIF2:GDP	R-HSA-72731	1.063304e-01	0.973
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	9.309787e-02	1.031
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	7.977837e-02	1.098
Phosphorylation of the APC/C	R-HSA-176412	7.977837e-02	1.098
G beta:gamma signalling through CDC42	R-HSA-8964616	9.324529e-02	1.030
Processing of Intronless Pre-mRNAs	R-HSA-77595	9.324529e-02	1.030
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	1.022117e-01	0.990
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	8.516649e-02	1.070
DNA Damage Recognition in GG-NER	R-HSA-5696394	8.909856e-02	1.050
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	9.207775e-02	1.036
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	1.005564e-01	0.998
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	9.208123e-02	1.036
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.019630e-02	1.045
Signaling by ERBB2	R-HSA-1227986	9.147112e-02	1.039
G-protein beta:gamma signalling	R-HSA-397795	7.989664e-02	1.097
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	7.989664e-02	1.097
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	9.309787e-02	1.031
UCH proteinases	R-HSA-5689603	1.025348e-01	0.989
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	7.977837e-02	1.098
Recycling pathway of L1	R-HSA-437239	1.005564e-01	0.998
rRNA processing	R-HSA-72312	9.838239e-02	1.007
CHL1 interactions	R-HSA-447041	1.063304e-01	0.973
Cellular responses to mechanical stimuli	R-HSA-9855142	8.768382e-02	1.057
Disorders of Developmental Biology	R-HSA-9675151	9.324529e-02	1.030
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	9.324529e-02	1.030
VEGFA-VEGFR2 Pathway	R-HSA-4420097	1.037912e-01	0.984
Signaling by NTRK1 (TRKA)	R-HSA-187037	9.734465e-02	1.012
Transcriptional Regulation by VENTX	R-HSA-8853884	1.003035e-01	0.999
RNA Polymerase II Transcription	R-HSA-73857	8.570166e-02	1.067
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	8.519766e-02	1.070
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	8.519766e-02	1.070
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	1.005229e-01	0.998
Activation of PUMA and translocation to mitochondria	R-HSA-139915	1.063304e-01	0.973
Uptake and function of diphtheria toxin	R-HSA-5336415	1.063304e-01	0.973
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	1.005229e-01	0.998
Transcriptional Regulation by E2F6	R-HSA-8953750	8.261874e-02	1.083
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	9.324529e-02	1.030
Amyloid fiber formation	R-HSA-977225	8.746394e-02	1.058
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	7.977837e-02	1.098
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	8.136023e-02	1.090
XBP1(S) activates chaperone genes	R-HSA-381038	8.006849e-02	1.097
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.070016e-01	0.971
Impaired BRCA2 binding to RAD51	R-HSA-9709570	1.070016e-01	0.971
DARPP-32 events	R-HSA-180024	1.070016e-01	0.971
Drug resistance of PDGFR mutants	R-HSA-9674415	1.071498e-01	0.970
PDGFR mutants bind TKIs	R-HSA-9674428	1.071498e-01	0.970
Sorafenib-resistant PDGFR mutants	R-HSA-9674404	1.071498e-01	0.970
Imatinib-resistant PDGFR mutants	R-HSA-9674396	1.071498e-01	0.970
Regorafenib-resistant PDGFR mutants	R-HSA-9674403	1.071498e-01	0.970
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	1.071498e-01	0.970
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.071498e-01	0.970
Sunitinib-resistant PDGFR mutants	R-HSA-9674401	1.071498e-01	0.970
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	1.077948e-01	0.967
Signaling by RAF1 mutants	R-HSA-9656223	1.098986e-01	0.959
Opioid Signalling	R-HSA-111885	1.105846e-01	0.956
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	1.107634e-01	0.956
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.107634e-01	0.956
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	1.107634e-01	0.956
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	1.107634e-01	0.956
MET interacts with TNS proteins	R-HSA-8875513	1.110296e-01	0.955
Defective SLC7A7 causes lysinuric protein intolerance (LPI)	R-HSA-5660862	1.110296e-01	0.955
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	1.110296e-01	0.955
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	1.153389e-01	0.938
Signaling by EGFR	R-HSA-177929	1.170417e-01	0.932
IRE1alpha activates chaperones	R-HSA-381070	1.176746e-01	0.929
Activation of the pre-replicative complex	R-HSA-68962	1.189407e-01	0.925
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	1.189407e-01	0.925
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.189407e-01	0.925
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	1.189407e-01	0.925
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	1.189407e-01	0.925
Inositol phosphate metabolism	R-HSA-1483249	1.194747e-01	0.923
G beta:gamma signalling through PLC beta	R-HSA-418217	1.233783e-01	0.909
Presynaptic function of Kainate receptors	R-HSA-500657	1.233783e-01	0.909
Signaling by VEGF	R-HSA-194138	1.235217e-01	0.908
EPH-Ephrin signaling	R-HSA-2682334	1.248172e-01	0.904
Transcriptional Regulation by TP53	R-HSA-3700989	1.258479e-01	0.900
PTEN Regulation	R-HSA-6807070	1.265463e-01	0.898
trans-Golgi Network Vesicle Budding	R-HSA-199992	1.285853e-01	0.891
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	1.288723e-01	0.890
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.288723e-01	0.890
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.292675e-01	0.889
Neurodegenerative Diseases	R-HSA-8863678	1.292675e-01	0.889
Formation of axial mesoderm	R-HSA-9796292	1.297926e-01	0.887
Type I hemidesmosome assembly	R-HSA-446107	1.307284e-01	0.884
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	1.307284e-01	0.884
Adrenoceptors	R-HSA-390696	1.307284e-01	0.884
SLC-mediated bile acid transport	R-HSA-9958517	1.307284e-01	0.884
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.307284e-01	0.884
EGFR downregulation	R-HSA-182971	1.315362e-01	0.881
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.316946e-01	0.880
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	1.329964e-01	0.876
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.028241e-01	0.693
Diseases of Telomere Maintenance	R-HSA-9673013	2.028241e-01	0.693
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.028241e-01	0.693
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	2.028241e-01	0.693
Impaired BRCA2 translocation to the nucleus	R-HSA-9709275	2.028241e-01	0.693
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.028241e-01	0.693
Defective Mismatch Repair Associated With MLH1	R-HSA-5545483	2.028241e-01	0.693
TICAM1 deficiency - HSE	R-HSA-5602566	2.028241e-01	0.693
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.028241e-01	0.693
Defective Mismatch Repair Associated With PMS2	R-HSA-5632987	2.028241e-01	0.693
Impaired BRCA2 binding to SEM1 (DSS1)	R-HSA-9763198	2.028241e-01	0.693
Inhibition of TSC complex formation by PKB	R-HSA-165181	1.488620e-01	0.827
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	1.488620e-01	0.827
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	1.887963e-01	0.724
IRS activation	R-HSA-74713	1.887963e-01	0.724
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	1.887963e-01	0.724
2-LTR circle formation	R-HSA-164843	1.844354e-01	0.734
CRMPs in Sema3A signaling	R-HSA-399956	1.500654e-01	0.824
G beta:gamma signalling through BTK	R-HSA-8964315	1.714525e-01	0.766
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	1.399377e-01	0.854
Impaired BRCA2 binding to PALB2	R-HSA-9709603	1.399377e-01	0.854
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	1.574071e-01	0.803
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	1.574071e-01	0.803
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	1.574071e-01	0.803
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	1.574071e-01	0.803
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	1.938176e-01	0.713
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	1.439615e-01	0.842
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	1.757139e-01	0.755
Signaling by PDGFR in disease	R-HSA-9671555	1.947803e-01	0.710
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	1.879531e-01	0.726
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	1.693496e-01	0.771
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	1.494214e-01	0.826
mRNA Splicing - Minor Pathway	R-HSA-72165	1.650564e-01	0.782
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	1.604313e-01	0.795
MAP2K and MAPK activation	R-HSA-5674135	1.968672e-01	0.706
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	1.968672e-01	0.706
HIV Transcription Initiation	R-HSA-167161	1.968672e-01	0.706
RNA Polymerase II Transcription Initiation	R-HSA-75953	1.968672e-01	0.706
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	1.835926e-01	0.736
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	1.957133e-01	0.708
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	1.477170e-01	0.831
Developmental Lineages of the Mammary Gland	R-HSA-9924644	2.030293e-01	0.692
Degradation of beta-catenin by the destruction complex	R-HSA-195253	1.812562e-01	0.742
PI3K/AKT Signaling in Cancer	R-HSA-2219528	1.768336e-01	0.752
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	1.679821e-01	0.775
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	1.574071e-01	0.803
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	1.585975e-01	0.800
Activation of the AP-1 family of transcription factors	R-HSA-450341	1.568629e-01	0.804
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	1.500654e-01	0.824
HDR through Homologous Recombination (HRR)	R-HSA-5685942	1.508371e-01	0.821
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	1.879531e-01	0.726
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	1.757139e-01	0.755
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	1.531091e-01	0.815
Nuclear events mediated by NFE2L2	R-HSA-9759194	1.412290e-01	0.850
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	1.844354e-01	0.734
KEAP1-NFE2L2 pathway	R-HSA-9755511	1.585125e-01	0.800
Signaling by WNT in cancer	R-HSA-4791275	1.447643e-01	0.839
Negative regulation of MET activity	R-HSA-6807004	1.574071e-01	0.803
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	1.879531e-01	0.726
VEGFR2 mediated vascular permeability	R-HSA-5218920	1.828837e-01	0.738
Ion homeostasis	R-HSA-5578775	1.957133e-01	0.708
rRNA modification in the nucleus and cytosol	R-HSA-6790901	1.883365e-01	0.725
Autophagy	R-HSA-9612973	1.403805e-01	0.853
Formation of definitive endoderm	R-HSA-9823730	1.574071e-01	0.803
HCMV Infection	R-HSA-9609646	1.840465e-01	0.735
Eukaryotic Translation Termination	R-HSA-72764	1.558309e-01	0.807
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.787342e-01	0.748
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	1.887963e-01	0.724
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	1.585975e-01	0.800
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	1.709153e-01	0.767
Protein methylation	R-HSA-8876725	1.714525e-01	0.766
Synthesis of DNA	R-HSA-69239	1.374525e-01	0.862
Macroautophagy	R-HSA-1632852	1.935089e-01	0.713
Transcriptional regulation by RUNX3	R-HSA-8878159	1.727560e-01	0.763
Negative regulation of MAPK pathway	R-HSA-5675221	1.968672e-01	0.706
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.845153e-01	0.734
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	1.395893e-01	0.855
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.754769e-01	0.756
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	1.718266e-01	0.765
Signaling by NOTCH4	R-HSA-9013694	1.460473e-01	0.836
Early Phase of HIV Life Cycle	R-HSA-162594	1.757139e-01	0.755
Protein-protein interactions at synapses	R-HSA-6794362	1.773985e-01	0.751
Muscle contraction	R-HSA-397014	1.531657e-01	0.815
Signaling by PTK6	R-HSA-8848021	1.883365e-01	0.725
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	1.883365e-01	0.725
NGF-stimulated transcription	R-HSA-9031628	1.902080e-01	0.721
Co-stimulation by CD28	R-HSA-389356	1.902080e-01	0.721
Formation of paraxial mesoderm	R-HSA-9793380	1.662118e-01	0.779
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	1.778486e-01	0.750
Smooth Muscle Contraction	R-HSA-445355	1.604313e-01	0.795
Ub-specific processing proteases	R-HSA-5689880	1.532441e-01	0.815
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	1.754769e-01	0.756
Diseases of DNA repair	R-HSA-9675135	1.650564e-01	0.782
SARS-CoV-2-host interactions	R-HSA-9705683	1.526354e-01	0.816
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	1.513649e-01	0.820
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	2.033719e-01	0.692
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	2.034051e-01	0.692
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	2.034051e-01	0.692
PKR-mediated signaling	R-HSA-9833482	2.053951e-01	0.687
Selenocysteine synthesis	R-HSA-2408557	2.092460e-01	0.679
Late endosomal microautophagy	R-HSA-9615710	2.095052e-01	0.679
Vesicle-mediated transport	R-HSA-5653656	2.103251e-01	0.677
Suppression of apoptosis	R-HSA-9635465	2.131538e-01	0.671
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	2.143297e-01	0.669
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	2.143297e-01	0.669
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	2.145250e-01	0.669
Regulation of RAS by GAPs	R-HSA-5658442	2.168986e-01	0.664
RUNX2 regulates bone development	R-HSA-8941326	2.193223e-01	0.659
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	2.208297e-01	0.656
AURKA Activation by TPX2	R-HSA-8854518	2.238497e-01	0.650
RNA Polymerase II Promoter Escape	R-HSA-73776	2.260682e-01	0.646
Signaling by ERBB2 in Cancer	R-HSA-1227990	2.273282e-01	0.643
SARS-CoV-2 Infection	R-HSA-9694516	2.284734e-01	0.641
Viral mRNA Translation	R-HSA-192823	2.287082e-01	0.641
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	2.299482e-01	0.638
Negative feedback regulation of MAPK pathway	R-HSA-5674499	2.299482e-01	0.638
Sodium-coupled phosphate cotransporters	R-HSA-427652	2.299482e-01	0.638
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	2.299482e-01	0.638
Regulation of CDH19 Expression and Function	R-HSA-9764302	2.299482e-01	0.638
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	2.348639e-01	0.629
Degradation of DVL	R-HSA-4641258	2.356645e-01	0.628
Mitochondrial biogenesis	R-HSA-1592230	2.375486e-01	0.624
Centrosome maturation	R-HSA-380287	2.376933e-01	0.624
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	2.376933e-01	0.624
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	2.389743e-01	0.622
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	2.409238e-01	0.618
G2/M Transition	R-HSA-69275	2.418181e-01	0.617
Integration of provirus	R-HSA-162592	2.427382e-01	0.615
Orc1 removal from chromatin	R-HSA-68949	2.449440e-01	0.611
Formation of RNA Pol II elongation complex	R-HSA-112382	2.449440e-01	0.611
G1/S Transition	R-HSA-69206	2.459110e-01	0.609
TRAF3 deficiency - HSE	R-HSA-5602571	2.882513e-01	0.540
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	2.882513e-01	0.540
Signaling by TCF7L2 mutants	R-HSA-5339700	2.882513e-01	0.540
Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)	R-HSA-5619045	2.882513e-01	0.540
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	2.882513e-01	0.540
Defective SLC34A2 causes PALM	R-HSA-5687583	2.882513e-01	0.540
Signalling to ERK5	R-HSA-198765	3.645285e-01	0.438
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.645285e-01	0.438
Signaling by RAS GAP mutants	R-HSA-9753510	3.645285e-01	0.438
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.645285e-01	0.438
Autointegration results in viral DNA circles	R-HSA-177539	2.715989e-01	0.566
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	2.715989e-01	0.566
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	3.131693e-01	0.504
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	4.326351e-01	0.364
Defective HPRT1 disrupts guanine and hypoxanthine salvage	R-HSA-9734281	4.326351e-01	0.364
Defective ABCA1 causes TGD	R-HSA-5682113	4.326351e-01	0.364
Invadopodia formation	R-HSA-8941237	4.326351e-01	0.364
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	2.729253e-01	0.564
RSK activation	R-HSA-444257	3.541986e-01	0.451
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	3.541986e-01	0.451
Signaling by MRAS-complex mutants	R-HSA-9660537	3.541986e-01	0.451
Regulation of NPAS4 mRNA translation	R-HSA-9768778	3.541986e-01	0.451
Formation of annular gap junctions	R-HSA-196025	3.541986e-01	0.451
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	3.541986e-01	0.451
Signaling by ERBB2 ECD mutants	R-HSA-9665348	2.653862e-01	0.576
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	2.557120e-01	0.592
Deadenylation of mRNA	R-HSA-429947	2.557120e-01	0.592
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	2.902736e-01	0.537
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	3.341530e-01	0.476
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	3.943257e-01	0.404
Lipophagy	R-HSA-9613354	3.943257e-01	0.404
WNT mediated activation of DVL	R-HSA-201688	3.943257e-01	0.404
Inactivation of CDC42 and RAC1	R-HSA-428543	3.943257e-01	0.404
Gap junction degradation	R-HSA-190873	3.943257e-01	0.404
CASP8 activity is inhibited	R-HSA-5218900	3.943257e-01	0.404
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	4.934459e-01	0.307
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	4.934459e-01	0.307
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	4.934459e-01	0.307
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine	R-HSA-9735763	4.934459e-01	0.307
PLCG1 events in ERBB2 signaling	R-HSA-1251932	4.934459e-01	0.307
Nucleotide catabolism defects	R-HSA-9735786	4.934459e-01	0.307
FBXW7 Mutants and NOTCH1 in Cancer	R-HSA-2644605	4.934459e-01	0.307
Signaling by MAP2K mutants	R-HSA-9652169	4.934459e-01	0.307
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	R-HSA-2644607	4.934459e-01	0.307
Defective LFNG causes SCDO3	R-HSA-5083630	4.934459e-01	0.307
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	4.934459e-01	0.307
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	3.154558e-01	0.501
Erythropoietin activates RAS	R-HSA-9027284	3.647704e-01	0.438
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	3.647704e-01	0.438
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	3.647704e-01	0.438
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	3.647704e-01	0.438
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	2.833457e-01	0.548
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	4.332728e-01	0.363
EPHA-mediated growth cone collapse	R-HSA-3928663	3.204608e-01	0.494
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	2.567096e-01	0.591
Aggrephagy	R-HSA-9646399	2.868160e-01	0.542
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	3.662167e-01	0.436
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	3.662167e-01	0.436
RNA Polymerase II Transcription Elongation	R-HSA-75955	2.594123e-01	0.586
Signaling by ERBB2 KD Mutants	R-HSA-9664565	3.646411e-01	0.438
FGFR2 alternative splicing	R-HSA-6803529	3.915701e-01	0.407
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	4.251200e-01	0.371
PECAM1 interactions	R-HSA-210990	4.708321e-01	0.327
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	2.889156e-01	0.539
Loss of Nlp from mitotic centrosomes	R-HSA-380259	2.889156e-01	0.539
RNA Polymerase I Transcription Initiation	R-HSA-73762	3.402397e-01	0.468
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	3.402397e-01	0.468
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	4.167690e-01	0.380
Signaling by EGFRvIII in Cancer	R-HSA-5637812	4.545599e-01	0.342
Constitutive Signaling by EGFRvIII	R-HSA-5637810	4.545599e-01	0.342
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	3.102362e-01	0.508
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	3.714550e-01	0.430
TRAF6 mediated NF-kB activation	R-HSA-933542	4.417217e-01	0.355
FOXO-mediated transcription of cell death genes	R-HSA-9614657	4.833490e-01	0.316
Ephrin signaling	R-HSA-3928664	4.833490e-01	0.316
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	4.833490e-01	0.316
G protein gated Potassium channels	R-HSA-1296059	4.663455e-01	0.331
Activation of G protein gated Potassium channels	R-HSA-1296041	4.663455e-01	0.331
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	4.663455e-01	0.331
Neutrophil degranulation	R-HSA-6798695	2.706954e-01	0.568
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	4.470530e-01	0.350
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	4.725704e-01	0.326
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	4.926174e-01	0.307
Transcription of the HIV genome	R-HSA-167172	2.488977e-01	0.604
Nucleotide Excision Repair	R-HSA-5696398	2.592512e-01	0.586
Signaling by NOTCH1	R-HSA-1980143	4.809446e-01	0.318
Polo-like kinase mediated events	R-HSA-156711	2.653862e-01	0.576
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	4.251200e-01	0.371
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	2.653862e-01	0.576
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	4.545599e-01	0.342
Asymmetric localization of PCP proteins	R-HSA-4608870	3.947661e-01	0.404
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	3.341530e-01	0.476
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	2.985943e-01	0.525
G-protein activation	R-HSA-202040	3.408090e-01	0.467
Mismatch Repair	R-HSA-5358508	2.653862e-01	0.576
Adipogenesis	R-HSA-9843745	3.139146e-01	0.503
Processing of SMDT1	R-HSA-8949664	3.034711e-01	0.518
VxPx cargo-targeting to cilium	R-HSA-5620916	3.154558e-01	0.501
Regulation of CDH11 function	R-HSA-9762292	4.332728e-01	0.363
PI3K/AKT activation	R-HSA-198203	4.332728e-01	0.363
Formation of Incision Complex in GG-NER	R-HSA-5696395	2.868160e-01	0.542
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	3.915701e-01	0.407
Elevation of cytosolic Ca2+ levels	R-HSA-139853	4.545599e-01	0.342
Deadenylation-dependent mRNA decay	R-HSA-429914	3.507663e-01	0.455
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	2.729253e-01	0.564
Killing mechanisms	R-HSA-9664420	3.951450e-01	0.403
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	3.951450e-01	0.403
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	3.951450e-01	0.403
Ca2+ pathway	R-HSA-4086398	3.153024e-01	0.501
Regulation by c-FLIP	R-HSA-3371378	3.541986e-01	0.451
Regulation of gap junction activity	R-HSA-191650	4.934459e-01	0.307
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	3.647704e-01	0.438
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	3.646411e-01	0.438
Regulation of mitotic cell cycle	R-HSA-453276	2.881845e-01	0.540
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	2.881845e-01	0.540
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	3.546211e-01	0.450
Thromboxane signalling through TP receptor	R-HSA-428930	4.417217e-01	0.355
Beta-catenin independent WNT signaling	R-HSA-3858494	3.759351e-01	0.425
Extra-nuclear estrogen signaling	R-HSA-9009391	2.935099e-01	0.532
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	4.905660e-01	0.309
Nuclear RNA decay	R-HSA-9930044	2.833457e-01	0.548
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	3.914652e-01	0.407
CD209 (DC-SIGN) signaling	R-HSA-5621575	2.557120e-01	0.592
Rap1 signalling	R-HSA-392517	2.902736e-01	0.537
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	2.523895e-01	0.598
GPER1 signaling	R-HSA-9634597	3.047982e-01	0.516
Listeria monocytogenes entry into host cells	R-HSA-8876384	3.662167e-01	0.436
Glycogen breakdown (glycogenolysis)	R-HSA-70221	2.769837e-01	0.558
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	3.204608e-01	0.494
Dimerization of procaspase-8	R-HSA-69416	3.541986e-01	0.451
Calcineurin activates NFAT	R-HSA-2025928	3.943257e-01	0.404
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	3.408090e-01	0.467
Hh mutants are degraded by ERAD	R-HSA-5362768	3.044299e-01	0.517
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	4.545599e-01	0.342
Post NMDA receptor activation events	R-HSA-438064	2.978789e-01	0.526
Activation of ATR in response to replication stress	R-HSA-176187	4.527417e-01	0.344
Degradation of GLI1 by the proteasome	R-HSA-5610780	4.803401e-01	0.318
Selective autophagy	R-HSA-9663891	4.199298e-01	0.377
Calmodulin induced events	R-HSA-111933	3.617926e-01	0.442
Regulation of MECP2 expression and activity	R-HSA-9022692	2.833457e-01	0.548
Prolonged ERK activation events	R-HSA-169893	3.951450e-01	0.403
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	3.647704e-01	0.438
CaM pathway	R-HSA-111997	3.617926e-01	0.442
G-protein mediated events	R-HSA-112040	4.770511e-01	0.321
DAG and IP3 signaling	R-HSA-1489509	3.947661e-01	0.404
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	3.541986e-01	0.451
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	2.902736e-01	0.537
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	2.567096e-01	0.591
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	2.885302e-01	0.540
Regulation of localization of FOXO transcription factors	R-HSA-9614399	4.708321e-01	0.327
Intra-Golgi traffic	R-HSA-6811438	4.803401e-01	0.318
Signaling by NOTCH3	R-HSA-9012852	4.221737e-01	0.375
Signaling by SCF-KIT	R-HSA-1433557	3.583491e-01	0.446
Resolution of Abasic Sites (AP sites)	R-HSA-73933	3.044299e-01	0.517
Glycogen metabolism	R-HSA-8982491	4.412413e-01	0.355
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	3.044299e-01	0.517
Hh mutants abrogate ligand secretion	R-HSA-5387390	3.583491e-01	0.446
Cellular response to starvation	R-HSA-9711097	2.744261e-01	0.562
CD28 dependent PI3K/Akt signaling	R-HSA-389357	3.204608e-01	0.494
Degradation of CRY and PER proteins	R-HSA-9932298	3.222523e-01	0.492
CLEC7A (Dectin-1) signaling	R-HSA-5607764	4.385610e-01	0.358
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	3.315882e-01	0.479
p75NTR signals via NF-kB	R-HSA-193639	3.647704e-01	0.438
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	4.663455e-01	0.331
Cellular response to chemical stress	R-HSA-9711123	3.617620e-01	0.442
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	2.882513e-01	0.540
Manipulation of host energy metabolism	R-HSA-9636667	2.882513e-01	0.540
Interleukin-33 signaling	R-HSA-9014843	3.645285e-01	0.438
Neurophilin interactions with VEGF and VEGFR	R-HSA-194306	3.645285e-01	0.438
Type II Na+/Pi cotransporters	R-HSA-427589	4.326351e-01	0.364
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	3.541986e-01	0.451
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	3.034711e-01	0.518
Regulation of KIT signaling	R-HSA-1433559	3.341530e-01	0.476
Unwinding of DNA	R-HSA-176974	3.943257e-01	0.404
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	4.934459e-01	0.307
AKT-mediated inactivation of FOXO1A	R-HSA-211163	4.934459e-01	0.307
Class I peroxisomal membrane protein import	R-HSA-9603798	3.951450e-01	0.403
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	3.425024e-01	0.465
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	3.402397e-01	0.468
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	3.816933e-01	0.418
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	4.089168e-01	0.388
RMTs methylate histone arginines	R-HSA-3214858	3.765382e-01	0.424
Defective CFTR causes cystic fibrosis	R-HSA-5678895	3.947661e-01	0.404
Golgi-to-ER retrograde transport	R-HSA-8856688	4.140562e-01	0.383
Mitotic G2-G2/M phases	R-HSA-453274	2.571599e-01	0.590
Somitogenesis	R-HSA-9824272	2.567096e-01	0.591
Neurexins and neuroligins	R-HSA-6794361	3.714550e-01	0.430
HDMs demethylate histones	R-HSA-3214842	2.769837e-01	0.558
Rab regulation of trafficking	R-HSA-9007101	4.161373e-01	0.381
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	4.905660e-01	0.309
Platelet sensitization by LDL	R-HSA-432142	2.653862e-01	0.576
tRNA modification in the mitochondrion	R-HSA-6787450	4.251200e-01	0.371
Signaling by MET	R-HSA-6806834	4.136100e-01	0.383
Regulation of necroptotic cell death	R-HSA-5675482	2.833457e-01	0.548
Signal attenuation	R-HSA-74749	4.332728e-01	0.363
TBC/RABGAPs	R-HSA-8854214	3.583491e-01	0.446
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	4.417217e-01	0.355
L1CAM interactions	R-HSA-373760	4.044992e-01	0.393
Toll-like Receptor Cascades	R-HSA-168898	4.296579e-01	0.367
FLT3 Signaling	R-HSA-9607240	3.044299e-01	0.517
Negative regulation of FLT3	R-HSA-9706369	3.951450e-01	0.403
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	3.524401e-01	0.453
Regulation of TP53 Activity through Methylation	R-HSA-6804760	4.833490e-01	0.316
Generic Transcription Pathway	R-HSA-212436	3.369159e-01	0.472
Nef and signal transduction	R-HSA-164944	2.715989e-01	0.566
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	3.222263e-01	0.492
Synthesis of PG	R-HSA-1483148	4.251200e-01	0.371
Degradation of GLI2 by the proteasome	R-HSA-5610783	4.803401e-01	0.318
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	4.803401e-01	0.318
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	2.748493e-01	0.561
Netrin-1 signaling	R-HSA-373752	3.765382e-01	0.424
RIPK1-mediated regulated necrosis	R-HSA-5213460	4.016015e-01	0.396
Integration of viral DNA into host genomic DNA	R-HSA-175567	2.715989e-01	0.566
Intracellular oxygen transport	R-HSA-8981607	4.326351e-01	0.364
GP1b-IX-V activation signalling	R-HSA-430116	3.943257e-01	0.404
Sensory perception of sour taste	R-HSA-9729555	4.934459e-01	0.307
Josephin domain DUBs	R-HSA-5689877	4.332728e-01	0.363
Glucagon signaling in metabolic regulation	R-HSA-163359	3.026716e-01	0.519
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	2.741426e-01	0.562
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	3.947661e-01	0.404
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	4.309171e-01	0.366
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	4.527417e-01	0.344
Negative regulation of NOTCH4 signaling	R-HSA-9604323	4.412413e-01	0.355
Signaling by NTRKs	R-HSA-166520	2.591535e-01	0.586
MAPK6/MAPK4 signaling	R-HSA-5687128	3.658360e-01	0.437
Signaling by TGF-beta Receptor Complex	R-HSA-170834	2.495508e-01	0.603
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	3.016635e-01	0.520
Transcriptional Regulation by MECP2	R-HSA-8986944	3.480325e-01	0.458
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	2.567096e-01	0.591
Signaling by TGFBR3	R-HSA-9839373	2.724893e-01	0.565
Signaling by TGFB family members	R-HSA-9006936	2.920305e-01	0.535
Cyclin E associated events during G1/S transition	R-HSA-69202	3.914652e-01	0.407
Degradation of CDH1	R-HSA-9766229	4.672926e-01	0.330
ABC-family proteins mediated transport	R-HSA-382556	3.807223e-01	0.419
Transcriptional regulation by RUNX2	R-HSA-8878166	4.394469e-01	0.357
Nuclear signaling by ERBB4	R-HSA-1251985	4.412413e-01	0.355
RET signaling	R-HSA-8853659	3.617926e-01	0.442
Histamine receptors	R-HSA-390650	4.326351e-01	0.364
Interleukin-37 signaling	R-HSA-9008059	3.868028e-01	0.413
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	3.616660e-01	0.442
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	4.214667e-01	0.375
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	3.947661e-01	0.404
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	3.947661e-01	0.404
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	4.833490e-01	0.316
Gastrulation	R-HSA-9758941	3.459995e-01	0.461
Displacement of DNA glycosylase by APEX1	R-HSA-110357	3.131693e-01	0.504
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	3.943257e-01	0.404
Regulation of HMOX1 expression and activity	R-HSA-9707587	4.934459e-01	0.307
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	4.332728e-01	0.363
Glucagon-type ligand receptors	R-HSA-420092	3.646411e-01	0.438
G1/S-Specific Transcription	R-HSA-69205	3.617926e-01	0.442
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	2.985943e-01	0.525
Regulation of PTEN stability and activity	R-HSA-8948751	3.883464e-01	0.411
Regulation of RUNX3 expression and activity	R-HSA-8941858	4.412413e-01	0.355
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	4.608799e-01	0.336
Cytokine Signaling in Immune system	R-HSA-1280215	4.798174e-01	0.319
Respiratory syncytial virus genome replication	R-HSA-9834752	3.943257e-01	0.404
Synthesis of PIPs at the ER membrane	R-HSA-1483248	4.708321e-01	0.327
Vpu mediated degradation of CD4	R-HSA-180534	4.743337e-01	0.324
Interleukin-7 signaling	R-HSA-1266695	4.663455e-01	0.331
Signaling by Interleukins	R-HSA-449147	2.605377e-01	0.584
Tandem pore domain potassium channels	R-HSA-1296346	4.332728e-01	0.363
Activation of kainate receptors upon glutamate binding	R-HSA-451326	3.425024e-01	0.465
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	4.251200e-01	0.371
Miscellaneous transport and binding events	R-HSA-5223345	4.743337e-01	0.324
Regulation of beta-cell development	R-HSA-186712	3.507663e-01	0.455
Uptake and function of anthrax toxins	R-HSA-5210891	4.545599e-01	0.342
NRAGE signals death through JNK	R-HSA-193648	4.390477e-01	0.357
Butyrophilin (BTN) family interactions	R-HSA-8851680	3.943257e-01	0.404
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	4.390477e-01	0.357
Unfolded Protein Response (UPR)	R-HSA-381119	3.204225e-01	0.494
Signaling by Leptin	R-HSA-2586552	4.332728e-01	0.363
Dual Incision in GG-NER	R-HSA-5696400	4.956406e-01	0.305
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	4.956406e-01	0.305
Signal amplification	R-HSA-392518	4.956406e-01	0.305
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	4.956406e-01	0.305
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	4.956406e-01	0.305
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	4.956406e-01	0.305
Ca-dependent events	R-HSA-111996	4.995826e-01	0.301
Activation of NF-kappaB in B cells	R-HSA-1169091	5.028309e-01	0.299
Hedgehog ligand biogenesis	R-HSA-5358346	5.028309e-01	0.299
Interleukin-1 signaling	R-HSA-9020702	5.030844e-01	0.298
Signaling by NOTCH1 in Cancer	R-HSA-2644603	5.056125e-01	0.296
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	5.056125e-01	0.296
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	5.056125e-01	0.296
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	5.056125e-01	0.296
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	5.056125e-01	0.296
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	5.068539e-01	0.295
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	5.068539e-01	0.295
ERKs are inactivated	R-HSA-202670	5.068539e-01	0.295
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	5.068539e-01	0.295
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	5.068539e-01	0.295
NF-kB is activated and signals survival	R-HSA-209560	5.068539e-01	0.295
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	5.068539e-01	0.295
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	5.068539e-01	0.295
Regulation of signaling by CBL	R-HSA-912631	5.113904e-01	0.291
IKK complex recruitment mediated by RIP1	R-HSA-937041	5.113904e-01	0.291
Signaling by FGFR2 IIIa TM	R-HSA-8851708	5.113904e-01	0.291
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	5.113904e-01	0.291
Maturation of nucleoprotein	R-HSA-9694631	5.113904e-01	0.291
Processive synthesis on the C-strand of the telomere	R-HSA-174414	5.143179e-01	0.289
Interaction between L1 and Ankyrins	R-HSA-445095	5.143179e-01	0.289
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	5.143179e-01	0.289
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	5.143179e-01	0.289
RNA Polymerase I Transcription Termination	R-HSA-73863	5.143179e-01	0.289
Insulin processing	R-HSA-264876	5.143179e-01	0.289
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	5.158023e-01	0.288
Signalling to ERKs	R-HSA-187687	5.166148e-01	0.287
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	5.166148e-01	0.287
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	5.166148e-01	0.287
Regulation of Apoptosis	R-HSA-169911	5.166148e-01	0.287
Translation	R-HSA-72766	5.194046e-01	0.284
Uptake and actions of bacterial toxins	R-HSA-5339562	5.203084e-01	0.284
PLC beta mediated events	R-HSA-112043	5.218909e-01	0.282
Aquaporin-mediated transport	R-HSA-445717	5.218909e-01	0.282
Regulation of RUNX2 expression and activity	R-HSA-8939902	5.218909e-01	0.282
Sensory processing of sound	R-HSA-9659379	5.247277e-01	0.280
Chaperonin-mediated protein folding	R-HSA-390466	5.260230e-01	0.279
Vif-mediated degradation of APOBEC3G	R-HSA-180585	5.372134e-01	0.270
Proteasome assembly	R-HSA-9907900	5.372712e-01	0.270
Telomere Extension By Telomerase	R-HSA-171319	5.375440e-01	0.270
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	5.375440e-01	0.270
Formation of the Early Elongation Complex	R-HSA-113418	5.375440e-01	0.270
HIV elongation arrest and recovery	R-HSA-167287	5.375440e-01	0.270
Pausing and recovery of HIV elongation	R-HSA-167290	5.375440e-01	0.270
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	5.375440e-01	0.270
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	5.379774e-01	0.269
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	5.379774e-01	0.269
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	5.384892e-01	0.269
Protein hydroxylation	R-HSA-9629569	5.386045e-01	0.269
RUNX3 regulates p14-ARF	R-HSA-8951936	5.412361e-01	0.267
Repression of WNT target genes	R-HSA-4641265	5.412361e-01	0.267
Scavenging by Class F Receptors	R-HSA-3000484	5.412361e-01	0.267
p75NTR recruits signalling complexes	R-HSA-209543	5.412361e-01	0.267
Pervasive developmental disorders	R-HSA-9005895	5.412361e-01	0.267
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	5.412361e-01	0.267
Disorders of Nervous System Development	R-HSA-9697154	5.412361e-01	0.267
SMAC (DIABLO) binds to IAPs	R-HSA-111463	5.477422e-01	0.261
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	5.477422e-01	0.261
NOSIP mediated eNOS trafficking	R-HSA-203754	5.477422e-01	0.261
Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)	R-HSA-5619067	5.477422e-01	0.261
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	5.477422e-01	0.261
FLT3 signaling by CBL mutants	R-HSA-9706377	5.477422e-01	0.261
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	5.477422e-01	0.261
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	5.477422e-01	0.261
Post-transcriptional silencing by small RNAs	R-HSA-426496	5.477422e-01	0.261
Muscarinic acetylcholine receptors	R-HSA-390648	5.477422e-01	0.261
Interleukin-36 pathway	R-HSA-9014826	5.477422e-01	0.261
NrCAM interactions	R-HSA-447038	5.477422e-01	0.261
Nectin/Necl trans heterodimerization	R-HSA-420597	5.477422e-01	0.261
Viral Infection Pathways	R-HSA-9824446	5.530433e-01	0.257
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	5.538509e-01	0.257
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	5.573983e-01	0.254
Degradation of AXIN	R-HSA-4641257	5.573983e-01	0.254
MITF-M-regulated melanocyte development	R-HSA-9730414	5.583003e-01	0.253
Termination of translesion DNA synthesis	R-HSA-5656169	5.601950e-01	0.252
Platelet calcium homeostasis	R-HSA-418360	5.601950e-01	0.252
Regulation of CDH11 Expression and Function	R-HSA-9759475	5.601950e-01	0.252
Regulation of gene expression in beta cells	R-HSA-210745	5.601950e-01	0.252
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	5.649274e-01	0.248
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	5.649274e-01	0.248
PKA-mediated phosphorylation of CREB	R-HSA-111931	5.649274e-01	0.248
Zygotic genome activation (ZGA)	R-HSA-9819196	5.649274e-01	0.248
Basigin interactions	R-HSA-210991	5.649274e-01	0.248
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	5.681949e-01	0.246
G alpha (z) signalling events	R-HSA-418597	5.712562e-01	0.243
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	5.739166e-01	0.241
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	5.739166e-01	0.241
Diseases of nucleotide metabolism	R-HSA-9735804	5.739166e-01	0.241
Frs2-mediated activation	R-HSA-170968	5.739166e-01	0.241
Maturation of nucleoprotein	R-HSA-9683610	5.739166e-01	0.241
Replication of the SARS-CoV-1 genome	R-HSA-9682706	5.739166e-01	0.241
Death Receptor Signaling	R-HSA-73887	5.755056e-01	0.240
SARS-CoV-1-host interactions	R-HSA-9692914	5.778225e-01	0.238
Cytoprotection by HMOX1	R-HSA-9707564	5.810531e-01	0.236
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.822294e-01	0.235
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	5.822294e-01	0.235
Activation of BH3-only proteins	R-HSA-114452	5.822294e-01	0.235
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	5.876678e-01	0.231
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	5.876678e-01	0.231
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	5.903099e-01	0.229
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	5.903099e-01	0.229
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	5.903099e-01	0.229
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	5.903099e-01	0.229
Attachment and Entry	R-HSA-9694614	5.903099e-01	0.229
Mitochondrial calcium ion transport	R-HSA-8949215	5.903099e-01	0.229
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	5.903099e-01	0.229
Ribavirin ADME	R-HSA-9755088	5.903099e-01	0.229
p75 NTR receptor-mediated signalling	R-HSA-193704	5.911531e-01	0.228
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	5.962214e-01	0.225
TRAIL signaling	R-HSA-75158	5.962214e-01	0.225
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	5.962214e-01	0.225
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	5.962214e-01	0.225
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	5.962214e-01	0.225
IkBA variant leads to EDA-ID	R-HSA-5603029	5.962214e-01	0.225
Noncanonical activation of NOTCH3	R-HSA-9017802	5.962214e-01	0.225
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	5.962214e-01	0.225
Signaling by RNF43 mutants	R-HSA-5340588	5.962214e-01	0.225
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	5.962214e-01	0.225
Aryl hydrocarbon receptor signalling	R-HSA-8937144	5.962214e-01	0.225
Pentose phosphate pathway disease	R-HSA-6791465	5.962214e-01	0.225
CDC6 association with the ORC:origin complex	R-HSA-68689	5.962214e-01	0.225
Synthesis of PS	R-HSA-1483101	5.962214e-01	0.225
CLEC7A/inflammasome pathway	R-HSA-5660668	5.962214e-01	0.225
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	5.963970e-01	0.224
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	5.963970e-01	0.224
Signaling by ALK	R-HSA-201556	5.963970e-01	0.224
Stabilization of p53	R-HSA-69541	5.963970e-01	0.224
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	5.970479e-01	0.224
Non-integrin membrane-ECM interactions	R-HSA-3000171	5.970479e-01	0.224
Hedgehog 'off' state	R-HSA-5610787	6.034755e-01	0.219
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	6.036128e-01	0.219
Downstream signal transduction	R-HSA-186763	6.036128e-01	0.219
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	6.048650e-01	0.218
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	6.048650e-01	0.218
HDL assembly	R-HSA-8963896	6.048650e-01	0.218
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	6.048650e-01	0.218
Malate-aspartate shuttle	R-HSA-9856872	6.048650e-01	0.218
Signal regulatory protein family interactions	R-HSA-391160	6.048650e-01	0.218
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	6.048650e-01	0.218
Protein folding	R-HSA-391251	6.055706e-01	0.218
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	6.073442e-01	0.217
SARS-CoV-1 Infection	R-HSA-9678108	6.129821e-01	0.213
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	6.147158e-01	0.211
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	6.151566e-01	0.211
HIV Transcription Elongation	R-HSA-167169	6.151566e-01	0.211
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	6.151566e-01	0.211
Early SARS-CoV-2 Infection Events	R-HSA-9772572	6.195190e-01	0.208
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	6.243177e-01	0.205
G0 and Early G1	R-HSA-1538133	6.243177e-01	0.205
Inwardly rectifying K+ channels	R-HSA-1296065	6.243177e-01	0.205
DNA strand elongation	R-HSA-69190	6.243177e-01	0.205
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	6.243177e-01	0.205
DNA Damage Bypass	R-HSA-73893	6.254942e-01	0.204
MITF-M-dependent gene expression	R-HSA-9856651	6.259993e-01	0.203
Regulated Necrosis	R-HSA-5218859	6.294017e-01	0.201
SARS-CoV Infections	R-HSA-9679506	6.304759e-01	0.200
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	6.333940e-01	0.198
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	6.333940e-01	0.198
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	6.340772e-01	0.198
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	6.340772e-01	0.198
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	6.340772e-01	0.198
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	6.340772e-01	0.198
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	6.340772e-01	0.198
ERBB2 Regulates Cell Motility	R-HSA-6785631	6.340772e-01	0.198
p38MAPK events	R-HSA-171007	6.340772e-01	0.198
Processive synthesis on the lagging strand	R-HSA-69183	6.340772e-01	0.198
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	6.340772e-01	0.198
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	6.340772e-01	0.198
Extension of Telomeres	R-HSA-180786	6.349273e-01	0.197
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	6.381205e-01	0.195
PCP/CE pathway	R-HSA-4086400	6.384944e-01	0.195
Signaling by LTK in cancer	R-HSA-9842640	6.395065e-01	0.194
Erythropoietin activates STAT5	R-HSA-9027283	6.395065e-01	0.194
STAT5 Activation	R-HSA-9645135	6.395065e-01	0.194
H139Hfs13* PPM1K causes a mild variant of MSUD	R-HSA-9912529	6.395065e-01	0.194
Defective CHST14 causes EDS, musculocontractural type	R-HSA-3595174	6.395065e-01	0.194
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	6.395065e-01	0.194
Defective CHST3 causes SEDCJD	R-HSA-3595172	6.395065e-01	0.194
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	6.395065e-01	0.194
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	6.395065e-01	0.194
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	6.395065e-01	0.194
G2/M DNA replication checkpoint	R-HSA-69478	6.395065e-01	0.194
Neurofascin interactions	R-HSA-447043	6.395065e-01	0.194
Abacavir transmembrane transport	R-HSA-2161517	6.395065e-01	0.194
Metabolism of vitamin K	R-HSA-6806664	6.395065e-01	0.194
NADPH regeneration	R-HSA-389542	6.395065e-01	0.194
HDL clearance	R-HSA-8964011	6.395065e-01	0.194
Leukotriene receptors	R-HSA-391906	6.395065e-01	0.194
Azathioprine ADME	R-HSA-9748787	6.419311e-01	0.193
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	6.443226e-01	0.191
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	6.443226e-01	0.191
FGFR1 mutant receptor activation	R-HSA-1839124	6.443226e-01	0.191
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	6.443226e-01	0.191
Interleukin-1 family signaling	R-HSA-446652	6.453301e-01	0.190
tRNA processing	R-HSA-72306	6.508197e-01	0.187
Signaling by FGFR1 in disease	R-HSA-5655302	6.510920e-01	0.186
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	6.517769e-01	0.186
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	6.605095e-01	0.180
Complex III assembly	R-HSA-9865881	6.605095e-01	0.180
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	6.615697e-01	0.179
Activation of SMO	R-HSA-5635838	6.615697e-01	0.179
Phase 4 - resting membrane potential	R-HSA-5576886	6.615697e-01	0.179
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	6.615697e-01	0.179
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	6.636121e-01	0.178
Activation of GABAB receptors	R-HSA-991365	6.682374e-01	0.175
GABA B receptor activation	R-HSA-977444	6.682374e-01	0.175
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	6.682374e-01	0.175
Hedgehog 'on' state	R-HSA-5632684	6.711740e-01	0.173
Negative regulation of the PI3K/AKT network	R-HSA-199418	6.726026e-01	0.172
RUNX3 regulates WNT signaling	R-HSA-8951430	6.781537e-01	0.169
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	6.781537e-01	0.169
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	6.781537e-01	0.169
TRIF-mediated programmed cell death	R-HSA-2562578	6.781537e-01	0.169
IFNG signaling activates MAPKs	R-HSA-9732724	6.781537e-01	0.169
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2	R-HSA-964827	6.781537e-01	0.169
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	6.781537e-01	0.169
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	6.781537e-01	0.169
Defective CHSY1 causes TPBS	R-HSA-3595177	6.781537e-01	0.169
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	6.781537e-01	0.169
PTK6 Expression	R-HSA-8849473	6.781537e-01	0.169
Disinhibition of SNARE formation	R-HSA-114516	6.781537e-01	0.169
Reuptake of GABA	R-HSA-888593	6.781537e-01	0.169
Activated NTRK3 signals through PI3K	R-HSA-9603381	6.781537e-01	0.169
VLDL clearance	R-HSA-8964046	6.781537e-01	0.169
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	6.781537e-01	0.169
Cation-coupled Chloride cotransporters	R-HSA-426117	6.781537e-01	0.169
Regulation of PTEN localization	R-HSA-8948747	6.781537e-01	0.169
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	6.781537e-01	0.169
Mitochondrial protein import	R-HSA-1268020	6.789349e-01	0.168
VEGFR2 mediated cell proliferation	R-HSA-5218921	6.818777e-01	0.166
Tight junction interactions	R-HSA-420029	6.818777e-01	0.166
Interferon Signaling	R-HSA-913531	6.821602e-01	0.166
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	6.821757e-01	0.166
Mitophagy	R-HSA-5205647	6.821757e-01	0.166
Signaling by NOTCH2	R-HSA-1980145	6.821757e-01	0.166
Platelet homeostasis	R-HSA-418346	6.844288e-01	0.165
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	6.848202e-01	0.164
MHC class II antigen presentation	R-HSA-2132295	6.862328e-01	0.164
GRB2 events in ERBB2 signaling	R-HSA-1963640	6.873755e-01	0.163
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	6.873755e-01	0.163
Defective B4GALT7 causes EDS, progeroid type	R-HSA-3560783	6.873755e-01	0.163
Defective B3GALT6 causes EDSP2 and SEMDJL1	R-HSA-4420332	6.873755e-01	0.163
Transcriptional regulation of testis differentiation	R-HSA-9690406	6.873755e-01	0.163
Acetylcholine regulates insulin secretion	R-HSA-399997	6.873755e-01	0.163
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	6.873755e-01	0.163
TRAF3-dependent IRF activation pathway	R-HSA-918233	6.873755e-01	0.163
Passive transport by Aquaporins	R-HSA-432047	6.873755e-01	0.163
G1/S DNA Damage Checkpoints	R-HSA-69615	6.928346e-01	0.159
Oncogene Induced Senescence	R-HSA-2559585	7.000081e-01	0.155
PERK regulates gene expression	R-HSA-381042	7.000081e-01	0.155
Amine ligand-binding receptors	R-HSA-375280	7.008336e-01	0.154
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	7.008336e-01	0.154
Signaling by EGFR in Cancer	R-HSA-1643713	7.022275e-01	0.154
Metalloprotease DUBs	R-HSA-5689901	7.022275e-01	0.154
Signaling by FLT3 fusion proteins	R-HSA-9703465	7.022275e-01	0.154
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	7.022275e-01	0.154
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	7.022275e-01	0.154
Ion transport by P-type ATPases	R-HSA-936837	7.063385e-01	0.151
Signaling by ERBB4	R-HSA-1236394	7.099579e-01	0.149
Signaling by FGFR in disease	R-HSA-1226099	7.099579e-01	0.149
PI3K events in ERBB2 signaling	R-HSA-1963642	7.115401e-01	0.148
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	7.115401e-01	0.148
Defective B3GAT3 causes JDSSDHD	R-HSA-3560801	7.115401e-01	0.148
Regulation of FZD by ubiquitination	R-HSA-4641263	7.115401e-01	0.148
Regulation of NPAS4 gene expression	R-HSA-9768759	7.115401e-01	0.148
Specification of primordial germ cells	R-HSA-9827857	7.115401e-01	0.148
Replication of the SARS-CoV-2 genome	R-HSA-9694686	7.115401e-01	0.148
Highly calcium permeable nicotinic acetylcholine receptors	R-HSA-629597	7.126597e-01	0.147
Myoclonic epilepsy of Lafora	R-HSA-3785653	7.126597e-01	0.147
MET receptor recycling	R-HSA-8875656	7.126597e-01	0.147
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	7.126597e-01	0.147
Axonal growth inhibition (RHOA activation)	R-HSA-193634	7.126597e-01	0.147
Fructose biosynthesis	R-HSA-5652227	7.126597e-01	0.147
Activation of RAS in B cells	R-HSA-1169092	7.126597e-01	0.147
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	7.126597e-01	0.147
Nucleotide salvage defects	R-HSA-9734207	7.126597e-01	0.147
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	7.126597e-01	0.147
ROBO receptors bind AKAP5	R-HSA-9010642	7.126597e-01	0.147
Fanconi Anemia Pathway	R-HSA-6783310	7.162737e-01	0.145
FLT3 signaling in disease	R-HSA-9682385	7.171081e-01	0.144
Regulation of TP53 Degradation	R-HSA-6804757	7.171081e-01	0.144
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	7.215683e-01	0.142
TCR signaling	R-HSA-202403	7.260033e-01	0.139
TNF signaling	R-HSA-75893	7.309988e-01	0.136
Regulation of TNFR1 signaling	R-HSA-5357905	7.311393e-01	0.136
PI Metabolism	R-HSA-1483255	7.322292e-01	0.135
TRAF6 mediated IRF7 activation	R-HSA-933541	7.334784e-01	0.135
Ovarian tumor domain proteases	R-HSA-5689896	7.334784e-01	0.135
PKA activation	R-HSA-163615	7.341189e-01	0.134
PKA activation in glucagon signalling	R-HSA-164378	7.341189e-01	0.134
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	7.341189e-01	0.134
Synaptic adhesion-like molecules	R-HSA-8849932	7.341189e-01	0.134
Tie2 Signaling	R-HSA-210993	7.341189e-01	0.134
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	7.341189e-01	0.134
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	7.341189e-01	0.134
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	7.365267e-01	0.133
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	7.365267e-01	0.133
Organelle biogenesis and maintenance	R-HSA-1852241	7.395138e-01	0.131
Activation of AMPK downstream of NMDARs	R-HSA-9619483	7.399153e-01	0.131
ARMS-mediated activation	R-HSA-170984	7.434680e-01	0.129
MAPK1 (ERK2) activation	R-HSA-112411	7.434680e-01	0.129
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	7.434680e-01	0.129
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	7.434680e-01	0.129
Enzymatic degradation of Dopamine by monoamine oxidase	R-HSA-379398	7.434680e-01	0.129
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	7.434680e-01	0.129
p75NTR regulates axonogenesis	R-HSA-193697	7.434680e-01	0.129
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	7.434680e-01	0.129
Regulation of signaling by NODAL	R-HSA-1433617	7.434680e-01	0.129
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	7.434680e-01	0.129
Regulation of CDH11 gene transcription	R-HSA-9762293	7.434680e-01	0.129
Interleukin-1 processing	R-HSA-448706	7.434680e-01	0.129
Regulated proteolysis of p75NTR	R-HSA-193692	7.434680e-01	0.129
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	7.434680e-01	0.129
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	7.441991e-01	0.128
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	7.454318e-01	0.128
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	7.454318e-01	0.128
Synthesis of PC	R-HSA-1483191	7.454318e-01	0.128
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	7.456163e-01	0.127
MET promotes cell motility	R-HSA-8875878	7.491252e-01	0.125
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	7.491252e-01	0.125
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	7.496078e-01	0.125
Pre-NOTCH Processing in Golgi	R-HSA-1912420	7.551739e-01	0.122
Translesion Synthesis by POLH	R-HSA-110320	7.551739e-01	0.122
E2F mediated regulation of DNA replication	R-HSA-113510	7.551739e-01	0.122
The NLRP3 inflammasome	R-HSA-844456	7.551739e-01	0.122
Specification of the neural plate border	R-HSA-9834899	7.551739e-01	0.122
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	7.551739e-01	0.122
ABC transporter disorders	R-HSA-5619084	7.567977e-01	0.121
Dual incision in TC-NER	R-HSA-6782135	7.569264e-01	0.121
Signaling by Erythropoietin	R-HSA-9006335	7.572883e-01	0.121
mRNA Capping	R-HSA-72086	7.572883e-01	0.121
Signaling by Hedgehog	R-HSA-5358351	7.634128e-01	0.117
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	7.640578e-01	0.117
Regulation of TP53 Expression and Degradation	R-HSA-6806003	7.640578e-01	0.117
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	7.709747e-01	0.113
Folding of actin by CCT/TriC	R-HSA-390450	7.709747e-01	0.113
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	R-HSA-629594	7.709747e-01	0.113
Binding and entry of HIV virion	R-HSA-173107	7.709747e-01	0.113
Enzymatic degradation of dopamine by COMT	R-HSA-379397	7.709747e-01	0.113
DNA replication initiation	R-HSA-68952	7.709747e-01	0.113
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	7.709747e-01	0.113
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	7.709747e-01	0.113
MET activates RAP1 and RAC1	R-HSA-8875555	7.709747e-01	0.113
Formation of intermediate mesoderm	R-HSA-9761174	7.709747e-01	0.113
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	7.709747e-01	0.113
Pexophagy	R-HSA-9664873	7.709747e-01	0.113
Maturation of spike protein	R-HSA-9683686	7.709747e-01	0.113
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	7.709747e-01	0.113
EGFR Transactivation by Gastrin	R-HSA-2179392	7.709747e-01	0.113
Regulation of the apoptosome activity	R-HSA-9627069	7.709747e-01	0.113
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	7.709747e-01	0.113
Formation of apoptosome	R-HSA-111458	7.709747e-01	0.113
Gap junction trafficking and regulation	R-HSA-157858	7.723133e-01	0.112
p53-Dependent G1 DNA Damage Response	R-HSA-69563	7.723133e-01	0.112
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	7.723133e-01	0.112
SLC transporter disorders	R-HSA-5619102	7.723679e-01	0.112
GABA synthesis, release, reuptake and degradation	R-HSA-888590	7.737112e-01	0.111
Signaling by NODAL	R-HSA-1181150	7.747724e-01	0.111
Pregnenolone biosynthesis	R-HSA-196108	7.747724e-01	0.111
Signal transduction by L1	R-HSA-445144	7.747724e-01	0.111
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	7.748221e-01	0.111
ER-Phagosome pathway	R-HSA-1236974	7.781625e-01	0.109
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	7.782880e-01	0.109
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	7.782880e-01	0.109
Generation of second messenger molecules	R-HSA-202433	7.782880e-01	0.109
MAPK family signaling cascades	R-HSA-5683057	7.852612e-01	0.105
Downstream TCR signaling	R-HSA-202424	7.877904e-01	0.104
Post-translational protein phosphorylation	R-HSA-8957275	7.880190e-01	0.103
Regulation of insulin secretion	R-HSA-422356	7.880190e-01	0.103
Trafficking of AMPA receptors	R-HSA-399719	7.892114e-01	0.103
Budding and maturation of HIV virion	R-HSA-162588	7.892114e-01	0.103
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	7.927811e-01	0.101
TNFR1-induced proapoptotic signaling	R-HSA-5357786	7.929846e-01	0.101
Signalling to RAS	R-HSA-167044	7.929846e-01	0.101
Lagging Strand Synthesis	R-HSA-69186	7.929846e-01	0.101
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	7.955335e-01	0.099
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	7.955335e-01	0.099
vRNP Assembly	R-HSA-192905	7.955335e-01	0.099
vRNA Synthesis	R-HSA-192814	7.955335e-01	0.099
RHOBTB3 ATPase cycle	R-HSA-9706019	7.955335e-01	0.099
Synthesis of PI	R-HSA-1483226	7.955335e-01	0.099
Hormone ligand-binding receptors	R-HSA-375281	7.955335e-01	0.099
Activated NTRK3 signals through RAS	R-HSA-9034864	7.955335e-01	0.099
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	7.955335e-01	0.099
Vitamin B1 (thiamin) metabolism	R-HSA-196819	7.955335e-01	0.099
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	7.955335e-01	0.099
CD163 mediating an anti-inflammatory response	R-HSA-9662834	7.955335e-01	0.099
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	7.999016e-01	0.097
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	8.046996e-01	0.094
Disorders of transmembrane transporters	R-HSA-5619115	8.067890e-01	0.093
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	8.098823e-01	0.092
Serine metabolism	R-HSA-977347	8.098823e-01	0.092
Signaling by NTRK3 (TRKC)	R-HSA-9034015	8.098823e-01	0.092
Platelet degranulation	R-HSA-114608	8.141451e-01	0.089
Cytosolic tRNA aminoacylation	R-HSA-379716	8.169148e-01	0.088
DS-GAG biosynthesis	R-HSA-2022923	8.174600e-01	0.088
Synthesis of diphthamide-EEF2	R-HSA-5358493	8.174600e-01	0.088
Condensation of Prometaphase Chromosomes	R-HSA-2514853	8.174600e-01	0.088
Endosomal/Vacuolar pathway	R-HSA-1236977	8.174600e-01	0.088
Sensing of DNA Double Strand Breaks	R-HSA-5693548	8.174600e-01	0.088
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	8.174600e-01	0.088
Presynaptic nicotinic acetylcholine receptors	R-HSA-622323	8.174600e-01	0.088
Reduction of cytosolic Ca++ levels	R-HSA-418359	8.174600e-01	0.088
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	8.174600e-01	0.088
Cytochrome c-mediated apoptotic response	R-HSA-111461	8.174600e-01	0.088
Sodium/Calcium exchangers	R-HSA-425561	8.174600e-01	0.088
Proton-coupled monocarboxylate transport	R-HSA-433692	8.174600e-01	0.088
Activated NTRK2 signals through RAS	R-HSA-9026519	8.174600e-01	0.088
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	8.175646e-01	0.087
Integrin signaling	R-HSA-354192	8.175646e-01	0.087
Cardiogenesis	R-HSA-9733709	8.175646e-01	0.087
Selenoamino acid metabolism	R-HSA-2408522	8.183376e-01	0.087
PPARA activates gene expression	R-HSA-1989781	8.235691e-01	0.084
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	8.255379e-01	0.083
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	8.255379e-01	0.083
Signaling by KIT in disease	R-HSA-9669938	8.255379e-01	0.083
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	8.255379e-01	0.083
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	8.255379e-01	0.083
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	8.258930e-01	0.083
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	8.261604e-01	0.083
RAF/MAP kinase cascade	R-HSA-5673001	8.262865e-01	0.083
Iron uptake and transport	R-HSA-917937	8.284877e-01	0.082
Response of Mtb to phagocytosis	R-HSA-9637690	8.284945e-01	0.082
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	8.286554e-01	0.082
Effects of PIP2 hydrolysis	R-HSA-114508	8.304825e-01	0.081
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	8.361143e-01	0.078
Adaptive Immune System	R-HSA-1280218	8.366885e-01	0.077
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	8.370364e-01	0.077
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	8.370364e-01	0.077
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	8.370364e-01	0.077
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	R-HSA-3656253	8.370364e-01	0.077
Defective EXT2 causes exostoses 2	R-HSA-3656237	8.370364e-01	0.077
Serotonin clearance from the synaptic cleft	R-HSA-380615	8.370364e-01	0.077
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	8.370364e-01	0.077
GRB2 events in EGFR signaling	R-HSA-179812	8.370364e-01	0.077
Signaling by LTK	R-HSA-9842663	8.370364e-01	0.077
MET activates RAS signaling	R-HSA-8851805	8.370364e-01	0.077
Maple Syrup Urine Disease	R-HSA-9865114	8.370364e-01	0.077
VLDLR internalisation and degradation	R-HSA-8866427	8.370364e-01	0.077
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	8.370364e-01	0.077
IRAK1 recruits IKK complex	R-HSA-937039	8.370364e-01	0.077
Regulation of IFNG signaling	R-HSA-877312	8.370364e-01	0.077
SHC-related events triggered by IGF1R	R-HSA-2428933	8.370364e-01	0.077
Diseases associated with surfactant metabolism	R-HSA-5687613	8.370364e-01	0.077
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	8.370364e-01	0.077
Interleukin-15 signaling	R-HSA-8983432	8.370364e-01	0.077
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	8.370364e-01	0.077
OAS antiviral response	R-HSA-8983711	8.370364e-01	0.077
Cyclin D associated events in G1	R-HSA-69231	8.394588e-01	0.076
G1 Phase	R-HSA-69236	8.394588e-01	0.076
Gap junction trafficking	R-HSA-190828	8.394588e-01	0.076
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	8.399270e-01	0.076
Paracetamol ADME	R-HSA-9753281	8.399270e-01	0.076
Regulation of PTEN mRNA translation	R-HSA-8943723	8.400236e-01	0.076
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	8.400236e-01	0.076
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	8.400236e-01	0.076
Interleukin receptor SHC signaling	R-HSA-912526	8.400236e-01	0.076
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	8.400236e-01	0.076
Growth hormone receptor signaling	R-HSA-982772	8.400236e-01	0.076
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	8.426066e-01	0.074
eNOS activation	R-HSA-203615	8.426066e-01	0.074
NOD1/2 Signaling Pathway	R-HSA-168638	8.426066e-01	0.074
Calnexin/calreticulin cycle	R-HSA-901042	8.426066e-01	0.074
Cardiac conduction	R-HSA-5576891	8.481661e-01	0.072
Intrinsic Pathway for Apoptosis	R-HSA-109606	8.494166e-01	0.071
Developmental Biology	R-HSA-1266738	8.508207e-01	0.070
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	8.534100e-01	0.069
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	8.534100e-01	0.069
Plasma lipoprotein assembly	R-HSA-8963898	8.534100e-01	0.069
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	8.538461e-01	0.069
COPI-mediated anterograde transport	R-HSA-6807878	8.539579e-01	0.069
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	8.545143e-01	0.068
Acetylcholine binding and downstream events	R-HSA-181431	8.545143e-01	0.068
Postsynaptic nicotinic acetylcholine receptors	R-HSA-622327	8.545143e-01	0.068
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	8.545143e-01	0.068
Reversible hydration of carbon dioxide	R-HSA-1475029	8.545143e-01	0.068
PI5P Regulates TP53 Acetylation	R-HSA-6811555	8.545143e-01	0.068
Membrane binding and targetting of GAG proteins	R-HSA-174490	8.545143e-01	0.068
rRNA modification in the mitochondrion	R-HSA-6793080	8.545143e-01	0.068
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	8.545143e-01	0.068
Interleukin-6 signaling	R-HSA-1059683	8.545143e-01	0.068
TP53 Regulates Metabolic Genes	R-HSA-5628897	8.565400e-01	0.067
MAPK1/MAPK3 signaling	R-HSA-5684996	8.578252e-01	0.067
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	8.596253e-01	0.066
Class I MHC mediated antigen processing & presentation	R-HSA-983169	8.635411e-01	0.064
C-type lectin receptors (CLRs)	R-HSA-5621481	8.644907e-01	0.063
FGFR2 mutant receptor activation	R-HSA-1839126	8.646132e-01	0.063
Long-term potentiation	R-HSA-9620244	8.657663e-01	0.063
MicroRNA (miRNA) biogenesis	R-HSA-203927	8.657663e-01	0.063
Acyl chain remodelling of PS	R-HSA-1482801	8.657663e-01	0.063
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	8.657663e-01	0.063
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	8.672829e-01	0.062
Removal of the Flap Intermediate	R-HSA-69166	8.701186e-01	0.060
N-glycan trimming and elongation in the cis-Golgi	R-HSA-964739	8.701186e-01	0.060
NRIF signals cell death from the nucleus	R-HSA-205043	8.701186e-01	0.060
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	8.701186e-01	0.060
Physiological factors	R-HSA-5578768	8.701186e-01	0.060
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.701186e-01	0.060
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	8.701186e-01	0.060
Ciprofloxacin ADME	R-HSA-9793528	8.701186e-01	0.060
Zinc transporters	R-HSA-435354	8.701186e-01	0.060
Signaling by FGFR4 in disease	R-HSA-5655291	8.701186e-01	0.060
Protein localization	R-HSA-9609507	8.701281e-01	0.060
Stimuli-sensing channels	R-HSA-2672351	8.712017e-01	0.060
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	8.771595e-01	0.057
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	8.771595e-01	0.057
Developmental Cell Lineages	R-HSA-9734767	8.818298e-01	0.055
Cargo trafficking to the periciliary membrane	R-HSA-5620920	8.820459e-01	0.055
GABA receptor activation	R-HSA-977443	8.828128e-01	0.054
Metabolism of polyamines	R-HSA-351202	8.828128e-01	0.054
SLC-mediated transport of inorganic anions	R-HSA-9958790	8.838638e-01	0.054
Adenylate cyclase inhibitory pathway	R-HSA-170670	8.840501e-01	0.054
RNA Polymerase III Chain Elongation	R-HSA-73780	8.840501e-01	0.054
Translesion synthesis by REV1	R-HSA-110312	8.840501e-01	0.054
Telomere C-strand synthesis initiation	R-HSA-174430	8.840501e-01	0.054
Dopamine clearance from the synaptic cleft	R-HSA-379401	8.840501e-01	0.054
Spry regulation of FGF signaling	R-HSA-1295596	8.840501e-01	0.054
SHC1 events in EGFR signaling	R-HSA-180336	8.840501e-01	0.054
Activation of BAD and translocation to mitochondria	R-HSA-111447	8.840501e-01	0.054
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	8.840501e-01	0.054
Other semaphorin interactions	R-HSA-416700	8.840501e-01	0.054
DNA Damage Reversal	R-HSA-73942	8.840501e-01	0.054
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	8.857973e-01	0.053
Platelet activation, signaling and aggregation	R-HSA-76002	8.862629e-01	0.052
Signaling by BMP	R-HSA-201451	8.876538e-01	0.052
Triglyceride biosynthesis	R-HSA-75109	8.876538e-01	0.052
ER Quality Control Compartment (ERQC)	R-HSA-901032	8.876538e-01	0.052
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	8.890854e-01	0.051
IRS-related events triggered by IGF1R	R-HSA-2428928	8.900988e-01	0.051
ER to Golgi Anterograde Transport	R-HSA-199977	8.909149e-01	0.050
Plasma lipoprotein clearance	R-HSA-8964043	8.925420e-01	0.049
Signaling by FGFR2 in disease	R-HSA-5655253	8.935224e-01	0.049
Translesion synthesis by POLI	R-HSA-5656121	8.964879e-01	0.047
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	8.964879e-01	0.047
WNT5A-dependent internalization of FZD4	R-HSA-5099900	8.964879e-01	0.047
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	8.964879e-01	0.047
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	8.964879e-01	0.047
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	8.964879e-01	0.047
Attachment and Entry	R-HSA-9678110	8.964879e-01	0.047
Regulation of NF-kappa B signaling	R-HSA-9758274	8.964879e-01	0.047
Signaling by PDGF	R-HSA-186797	8.969913e-01	0.047
Inflammasomes	R-HSA-622312	8.973111e-01	0.047
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	8.973111e-01	0.047
Pyroptosis	R-HSA-5620971	8.973111e-01	0.047
RSV-host interactions	R-HSA-9833110	9.075622e-01	0.042
Translesion synthesis by POLK	R-HSA-5655862	9.075923e-01	0.042
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	9.075923e-01	0.042
SHC1 events in ERBB4 signaling	R-HSA-1250347	9.075923e-01	0.042
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	9.075923e-01	0.042
Galactose catabolism	R-HSA-70370	9.075923e-01	0.042
Coenzyme A biosynthesis	R-HSA-196783	9.075923e-01	0.042
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	9.075923e-01	0.042
Maturation of spike protein	R-HSA-9694548	9.081713e-01	0.042
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.088254e-01	0.042
IGF1R signaling cascade	R-HSA-2428924	9.096588e-01	0.041
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	9.096588e-01	0.041
Leishmania infection	R-HSA-9658195	9.098660e-01	0.041
Parasitic Infection Pathways	R-HSA-9824443	9.098660e-01	0.041
Amino acids regulate mTORC1	R-HSA-9639288	9.140081e-01	0.039
Neurotransmitter clearance	R-HSA-112311	9.143466e-01	0.039
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.143466e-01	0.039
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.143881e-01	0.039
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	9.151867e-01	0.038
Translation of Structural Proteins	R-HSA-9683701	9.151867e-01	0.038
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	9.154649e-01	0.038
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	9.175059e-01	0.037
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	9.175059e-01	0.037
Glycogen storage diseases	R-HSA-3229121	9.175059e-01	0.037
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	9.175059e-01	0.037
Catecholamine biosynthesis	R-HSA-209905	9.175059e-01	0.037
Choline catabolism	R-HSA-6798163	9.175059e-01	0.037
Translation of Structural Proteins	R-HSA-9694635	9.182596e-01	0.037
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.218334e-01	0.035
Evasion by RSV of host interferon responses	R-HSA-9833109	9.218334e-01	0.035
SLC-mediated transport of organic anions	R-HSA-9955298	9.232441e-01	0.035
Antigen processing-Cross presentation	R-HSA-1236975	9.254303e-01	0.034
SLC-mediated transport of amino acids	R-HSA-9958863	9.260986e-01	0.033
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	9.263566e-01	0.033
RNA Polymerase III Transcription Termination	R-HSA-73980	9.263566e-01	0.033
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	9.263566e-01	0.033
Apoptotic factor-mediated response	R-HSA-111471	9.263566e-01	0.033
Transport of connexons to the plasma membrane	R-HSA-190872	9.263566e-01	0.033
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	9.263566e-01	0.033
GAB1 signalosome	R-HSA-180292	9.263566e-01	0.033
Integration of energy metabolism	R-HSA-163685	9.276578e-01	0.033
Signaling by FGFR2	R-HSA-5654738	9.324182e-01	0.030
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	9.342581e-01	0.030
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	9.342581e-01	0.030
Other interleukin signaling	R-HSA-449836	9.342581e-01	0.030
Recycling of bile acids and salts	R-HSA-159418	9.349939e-01	0.029
Neuronal System	R-HSA-112316	9.356427e-01	0.029
IRS-mediated signalling	R-HSA-112399	9.358272e-01	0.029
Cilium Assembly	R-HSA-5617833	9.377287e-01	0.028
Platelet Aggregation (Plug Formation)	R-HSA-76009	9.386199e-01	0.028
COPII-mediated vesicle transport	R-HSA-204005	9.398233e-01	0.027
Transmission across Chemical Synapses	R-HSA-112315	9.405200e-01	0.027
Leishmania phagocytosis	R-HSA-9664417	9.407151e-01	0.027
Parasite infection	R-HSA-9664407	9.407151e-01	0.027
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.407151e-01	0.027
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	9.407584e-01	0.027
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	9.407584e-01	0.027
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	9.407584e-01	0.027
Heme degradation	R-HSA-189483	9.407584e-01	0.027
Regulation of PD-L1(CD274) translation	R-HSA-9909620	9.413123e-01	0.026
Post-chaperonin tubulin folding pathway	R-HSA-389977	9.413123e-01	0.026
Glycogen synthesis	R-HSA-3322077	9.413123e-01	0.026
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	9.413123e-01	0.026
Creatine metabolism	R-HSA-71288	9.413123e-01	0.026
Eicosanoid ligand-binding receptors	R-HSA-391903	9.413123e-01	0.026
Amino acid transport across the plasma membrane	R-HSA-352230	9.447344e-01	0.025
Triglyceride metabolism	R-HSA-8979227	9.447344e-01	0.025
NPAS4 regulates expression of target genes	R-HSA-9768919	9.460347e-01	0.024
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.460347e-01	0.024
Gap junction assembly	R-HSA-190861	9.460347e-01	0.024
Hyaluronan metabolism	R-HSA-2142845	9.460347e-01	0.024
Matriglycan biosynthesis on DAG1	R-HSA-9939291	9.476099e-01	0.023
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	9.476099e-01	0.023
SHC-mediated cascade:FGFR3	R-HSA-5654704	9.476099e-01	0.023
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	9.476099e-01	0.023
tRNA Aminoacylation	R-HSA-379724	9.487505e-01	0.023
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	9.489710e-01	0.023
Transferrin endocytosis and recycling	R-HSA-917977	9.508613e-01	0.022
Gluconeogenesis	R-HSA-70263	9.520932e-01	0.021
CS-GAG biosynthesis	R-HSA-2022870	9.532320e-01	0.021
SHC-mediated cascade:FGFR4	R-HSA-5654719	9.532320e-01	0.021
FRS-mediated FGFR3 signaling	R-HSA-5654706	9.532320e-01	0.021
Glutathione synthesis and recycling	R-HSA-174403	9.532320e-01	0.021
Assembly Of The HIV Virion	R-HSA-175474	9.532320e-01	0.021
Lysosome Vesicle Biogenesis	R-HSA-432720	9.552738e-01	0.020
GPVI-mediated activation cascade	R-HSA-114604	9.552738e-01	0.020
Triglyceride catabolism	R-HSA-163560	9.552738e-01	0.020
Potassium Channels	R-HSA-1296071	9.577903e-01	0.019
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	9.582512e-01	0.019
Neurotoxicity of clostridium toxins	R-HSA-168799	9.582512e-01	0.019
RAF-independent MAPK1/3 activation	R-HSA-112409	9.582512e-01	0.019
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.582512e-01	0.019
FRS-mediated FGFR4 signaling	R-HSA-5654712	9.582512e-01	0.019
Fructose metabolism	R-HSA-5652084	9.582512e-01	0.019
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	9.582512e-01	0.019
Ethanol oxidation	R-HSA-71384	9.582512e-01	0.019
Cellular hexose transport	R-HSA-189200	9.582512e-01	0.019
LDL clearance	R-HSA-8964038	9.582512e-01	0.019
PI3K Cascade	R-HSA-109704	9.594827e-01	0.018
Ion channel transport	R-HSA-983712	9.598042e-01	0.018
Neddylation	R-HSA-8951664	9.616839e-01	0.017
Insulin receptor signalling cascade	R-HSA-74751	9.622753e-01	0.017
Free fatty acids regulate insulin secretion	R-HSA-400451	9.627319e-01	0.016
Carnitine shuttle	R-HSA-200425	9.627319e-01	0.016
ABC transporters in lipid homeostasis	R-HSA-1369062	9.627319e-01	0.016
Mitochondrial mRNA modification	R-HSA-9937008	9.627319e-01	0.016
Formation of the ureteric bud	R-HSA-9830674	9.627319e-01	0.016
Purine salvage	R-HSA-74217	9.629873e-01	0.016
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	9.629873e-01	0.016
Transcriptional Regulation by NPAS4	R-HSA-9634815	9.657916e-01	0.015
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	9.657916e-01	0.015
G alpha (s) signalling events	R-HSA-418555	9.664749e-01	0.015
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	9.667320e-01	0.015
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	9.667320e-01	0.015
SHC-mediated cascade:FGFR1	R-HSA-5654688	9.667320e-01	0.015
Mitochondrial RNA degradation	R-HSA-9836573	9.667320e-01	0.015
Interleukin-6 family signaling	R-HSA-6783589	9.667320e-01	0.015
Neurotransmitter release cycle	R-HSA-112310	9.675042e-01	0.014
Class B/2 (Secretin family receptors)	R-HSA-373080	9.675042e-01	0.014
Diseases associated with the TLR signaling cascade	R-HSA-5602358	9.694137e-01	0.013
Diseases of Immune System	R-HSA-5260271	9.694137e-01	0.013
rRNA processing in the mitochondrion	R-HSA-8868766	9.694137e-01	0.013
Interleukin-2 family signaling	R-HSA-451927	9.694137e-01	0.013
Polymerase switching on the C-strand of the telomere	R-HSA-174411	9.703029e-01	0.013
FRS-mediated FGFR1 signaling	R-HSA-5654693	9.703029e-01	0.013
Hyaluronan degradation	R-HSA-2160916	9.703029e-01	0.013
Laminin interactions	R-HSA-3000157	9.703029e-01	0.013
MET activates PTK2 signaling	R-HSA-8874081	9.734908e-01	0.012
Urea cycle	R-HSA-70635	9.734908e-01	0.012
Abacavir ADME	R-HSA-2161522	9.734908e-01	0.012
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	9.734908e-01	0.012
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.734908e-01	0.012
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.736155e-01	0.012
Immune System	R-HSA-168256	9.736866e-01	0.012
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.747575e-01	0.011
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.763366e-01	0.010
Cristae formation	R-HSA-8949613	9.763366e-01	0.010
SHC-mediated cascade:FGFR2	R-HSA-5654699	9.763366e-01	0.010
Synthesis of PE	R-HSA-1483213	9.763366e-01	0.010
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.763366e-01	0.010
Signaling by NTRK2 (TRKB)	R-HSA-9006115	9.763366e-01	0.010
Maturation of hRSV A proteins	R-HSA-9828806	9.763366e-01	0.010
Signaling by FGFR3 in disease	R-HSA-5655332	9.763366e-01	0.010
G alpha (q) signalling events	R-HSA-416476	9.767468e-01	0.010
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.785694e-01	0.009
Phase 0 - rapid depolarisation	R-HSA-5576892	9.788770e-01	0.009
Negative regulation of FGFR3 signaling	R-HSA-5654732	9.788770e-01	0.009
FRS-mediated FGFR2 signaling	R-HSA-5654700	9.788770e-01	0.009
Phosphate bond hydrolysis by NTPDase proteins	R-HSA-8850843	9.788770e-01	0.009
Insulin receptor recycling	R-HSA-77387	9.788770e-01	0.009
Iron assimilation using enterobactin	R-HSA-9638334	9.788770e-01	0.009
Signaling by FGFR4	R-HSA-5654743	9.791931e-01	0.009
Surfactant metabolism	R-HSA-5683826	9.811177e-01	0.008
Negative regulation of FGFR4 signaling	R-HSA-5654733	9.811449e-01	0.008
Downstream signaling of activated FGFR3	R-HSA-5654708	9.811449e-01	0.008
Signaling by CSF3 (G-CSF)	R-HSA-9674555	9.811449e-01	0.008
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.813148e-01	0.008
Potential therapeutics for SARS	R-HSA-9679191	9.824889e-01	0.008
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.828690e-01	0.008
Signaling by FGFR3	R-HSA-5654741	9.828690e-01	0.008
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.828859e-01	0.007
Downstream signaling of activated FGFR4	R-HSA-5654716	9.831693e-01	0.007
DAP12 signaling	R-HSA-2424491	9.831693e-01	0.007
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.834686e-01	0.007
Leishmania parasite growth and survival	R-HSA-9664433	9.834686e-01	0.007
Signaling by FGFR	R-HSA-190236	9.839806e-01	0.007
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.844620e-01	0.007
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.844620e-01	0.007
Regulation of pyruvate metabolism	R-HSA-9861718	9.844620e-01	0.007
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.844620e-01	0.007
Phospholipid metabolism	R-HSA-1483257	9.849421e-01	0.007
Molecules associated with elastic fibres	R-HSA-2129379	9.849765e-01	0.007
Cargo concentration in the ER	R-HSA-5694530	9.849765e-01	0.007
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	9.849765e-01	0.007
Aspartate and asparagine metabolism	R-HSA-8963693	9.849765e-01	0.007
FOXO-mediated transcription	R-HSA-9614085	9.851035e-01	0.007
NCAM signaling for neurite out-growth	R-HSA-375165	9.856571e-01	0.006
DAG1 glycosylations	R-HSA-8931838	9.865898e-01	0.006
HS-GAG degradation	R-HSA-2024096	9.865898e-01	0.006
Intraflagellar transport	R-HSA-5620924	9.872274e-01	0.006
Metal ion SLC transporters	R-HSA-425410	9.872274e-01	0.006
FCERI mediated NF-kB activation	R-HSA-2871837	9.876848e-01	0.005
Negative regulation of FGFR1 signaling	R-HSA-5654726	9.880299e-01	0.005
Transport to the Golgi and subsequent modification	R-HSA-948021	9.883091e-01	0.005
Chemokine receptors bind chemokines	R-HSA-380108	9.884239e-01	0.005
Infectious disease	R-HSA-5663205	9.888625e-01	0.005
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	9.892061e-01	0.005
CS/DS degradation	R-HSA-2024101	9.893155e-01	0.005
Acyl chain remodelling of PC	R-HSA-1482788	9.893155e-01	0.005
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.893155e-01	0.005
Signaling by Insulin receptor	R-HSA-74752	9.898569e-01	0.004
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.898569e-01	0.004
Negative regulation of FGFR2 signaling	R-HSA-5654727	9.904630e-01	0.004
RA biosynthesis pathway	R-HSA-5365859	9.904630e-01	0.004
Phosphate bond hydrolysis by NUDT proteins	R-HSA-2393930	9.904630e-01	0.004
Complex IV assembly	R-HSA-9864848	9.904979e-01	0.004
The phototransduction cascade	R-HSA-2514856	9.904979e-01	0.004
Acyl chain remodelling of PE	R-HSA-1482839	9.914873e-01	0.004
Downstream signaling of activated FGFR2	R-HSA-5654696	9.914873e-01	0.004
Downstream signaling of activated FGFR1	R-HSA-5654687	9.914873e-01	0.004
HS-GAG biosynthesis	R-HSA-2022928	9.924017e-01	0.003
Voltage gated Potassium channels	R-HSA-1296072	9.932179e-01	0.003
Collagen chain trimerization	R-HSA-8948216	9.932179e-01	0.003
Metabolism of cofactors	R-HSA-8978934	9.936182e-01	0.003
tRNA processing in the mitochondrion	R-HSA-6785470	9.939465e-01	0.003
Elastic fibre formation	R-HSA-1566948	9.939465e-01	0.003
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.942217e-01	0.003
Signaling by FGFR1	R-HSA-5654736	9.942217e-01	0.003
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.942421e-01	0.003
RAS processing	R-HSA-9648002	9.945969e-01	0.002
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.945969e-01	0.002
Pentose phosphate pathway	R-HSA-71336	9.945969e-01	0.002
Synthesis of PA	R-HSA-1483166	9.947720e-01	0.002
Post-translational protein modification	R-HSA-597592	9.950344e-01	0.002
Tryptophan catabolism	R-HSA-71240	9.951774e-01	0.002
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.951774e-01	0.002
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.956955e-01	0.002
Aflatoxin activation and detoxification	R-HSA-5423646	9.956955e-01	0.002
Peroxisomal protein import	R-HSA-9033241	9.957229e-01	0.002
Innate Immune System	R-HSA-168249	9.959645e-01	0.002
Hemostasis	R-HSA-109582	9.959807e-01	0.002
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	9.961581e-01	0.002
Scavenging by Class A Receptors	R-HSA-3000480	9.961581e-01	0.002
Heme biosynthesis	R-HSA-189451	9.961581e-01	0.002
Nucleotide salvage	R-HSA-8956321	9.965033e-01	0.002
Collagen degradation	R-HSA-1442490	9.965033e-01	0.002
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.965709e-01	0.001
Integrin cell surface interactions	R-HSA-216083	9.966504e-01	0.001
Glycerophospholipid biosynthesis	R-HSA-1483206	9.972632e-01	0.001
Methylation	R-HSA-156581	9.972683e-01	0.001
DAP12 interactions	R-HSA-2172127	9.972683e-01	0.001
Mitochondrial protein degradation	R-HSA-9837999	9.973573e-01	0.001
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.974677e-01	0.001
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.978932e-01	0.001
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	9.980579e-01	0.001
Metabolism of steroid hormones	R-HSA-196071	9.980971e-01	0.001
Formation of the cornified envelope	R-HSA-6809371	9.982715e-01	0.001
FCERI mediated MAPK activation	R-HSA-2871796	9.983135e-01	0.001
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.986438e-01	0.001
Pyruvate metabolism	R-HSA-70268	9.986910e-01	0.001
Retinoid metabolism and transport	R-HSA-975634	9.987354e-01	0.001
Metabolism of porphyrins	R-HSA-189445	9.987354e-01	0.001
Cytosolic sulfonation of small molecules	R-HSA-156584	9.987678e-01	0.001
Branched-chain amino acid catabolism	R-HSA-70895	9.987678e-01	0.001
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.987840e-01	0.001
Purine catabolism	R-HSA-74259	9.988586e-01	0.000
Interferon alpha/beta signaling	R-HSA-909733	9.988965e-01	0.000
Diseases of carbohydrate metabolism	R-HSA-5663084	9.989700e-01	0.000
Nucleotide biosynthesis	R-HSA-8956320	9.990185e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.990701e-01	0.000
Disease	R-HSA-1643685	9.991014e-01	0.000
Chondroitin sulfate/dermatan sulfate metabolism	R-HSA-1793185	9.992183e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.992433e-01	0.000
Metabolism of amine-derived hormones	R-HSA-209776	9.993023e-01	0.000
Interleukin-10 signaling	R-HSA-6783783	9.993846e-01	0.000
Cholesterol biosynthesis	R-HSA-191273	9.993846e-01	0.000
Collagen formation	R-HSA-1474290	9.993910e-01	0.000
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.994451e-01	0.000
Heparan sulfate/heparin (HS-GAG) metabolism	R-HSA-1638091	9.995041e-01	0.000
Glutathione conjugation	R-HSA-156590	9.995574e-01	0.000
Signaling by Retinoic Acid	R-HSA-5362517	9.995574e-01	0.000
Endogenous sterols	R-HSA-211976	9.996051e-01	0.000
Complex I biogenesis	R-HSA-6799198	9.996855e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.997229e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.997432e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.997895e-01	0.000
Nicotinate metabolism	R-HSA-196807	9.998005e-01	0.000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.998005e-01	0.000
Kidney development	R-HSA-9830369	9.998005e-01	0.000
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.998220e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.998414e-01	0.000
Respiratory electron transport	R-HSA-611105	9.998533e-01	0.000
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.998583e-01	0.000
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.998735e-01	0.000
ECM proteoglycans	R-HSA-3000178	9.998735e-01	0.000
Metal ion assimilation from the host	R-HSA-9638482	9.998735e-01	0.000
Metabolism of proteins	R-HSA-392499	9.998879e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.998900e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.998950e-01	0.000
FCGR activation	R-HSA-2029481	9.998954e-01	0.000
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.998954e-01	0.000
Aspirin ADME	R-HSA-9749641	9.998993e-01	0.000
Citric acid cycle (TCA cycle)	R-HSA-71403	9.999198e-01	0.000
Transport of small molecules	R-HSA-382551	9.999245e-01	0.000
Interferon gamma signaling	R-HSA-877300	9.999356e-01	0.000
Drug ADME	R-HSA-9748784	9.999462e-01	0.000
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.999476e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.999500e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.999636e-01	0.000
Extracellular matrix organization	R-HSA-1474244	9.999659e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.999712e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999874e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.999884e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999892e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999909e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999932e-01	0.000
Scavenging of heme from plasma	R-HSA-2168880	9.999942e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999947e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.999948e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.999948e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.999959e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999977e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999989e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999989e-01	0.000
Sensory perception of taste	R-HSA-9717189	9.999990e-01	0.000
Keratinization	R-HSA-6805567	9.999992e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999993e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999996e-01	0.000
Signaling by GPCR	R-HSA-372790	9.999998e-01	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999998e-01	0.000
Asparagine N-linked glycosylation	R-HSA-446203	9.999999e-01	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	9.999999e-01	0.000
Bacterial Infection Pathways	R-HSA-9824439	9.999999e-01	0.000
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000
O-linked glycosylation	R-HSA-5173105	1.000000e+00	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
Mitochondrial translation	R-HSA-5368287	1.000000e+00	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000
Sphingolipid metabolism	R-HSA-428157	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	-0.000