BMPR1B

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A0MZ66 S473 Sugiyama SHTN1 KIAA1598 LGtLNKSTSSRsLKsLDPENsEtELERILRRRKVtAEADss
A5A3E0 S1065 Sugiyama POTEF A26C1B ILASLSTFQQMWISKQEyDEsGPsIVHRKCL__________
A5A3E0 T949 Sugiyama POTEF A26C1B TVAsSSSLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
A5A3E0 Y940 Sugiyama POTEF A26C1B ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
O00170 T48 Sugiyama AIP XAP2 FQDGTKATFHYRtLHsDDEGtVLDDsRARGKPMELIIGKKF
O00238 S497 Sugiyama BMPR1B NPASRLTALRVKKTLAKMSEsQDIKL_______________
O00299 S156 Sugiyama CLIC1 G6 NCC27 ALKVLDNyLTsPLPEEVDEtsAEDEGVsQRKFLDGNELTLA
O00505 S60 Sugiyama KPNA3 QIP2 KRDEHLLKKRNVPQEEsLEDsDVDADFKAQNVTLEAILQNA
O15067 S530 Sugiyama PFAS KIAA0361 PICsLHDQGAGGNGNVLKELsDPAGAIIytsRFQLGDPTLN
O15270 T560 Sugiyama SPTLC2 KIAA0526 LCB2 SRHRLVPLLDRPFDETTyEEtED__________________
O43852 S261 Sugiyama CALU RDKNRDGKMDKEEtKDWILPsDyDHAEAEARHLVyEsDQNK
O60220 S96 Sugiyama TIMM8A DDP DDP1 TIM8A FILNRLEQTQKSKPVFSEsLsD___________________
O60231 S319 Sugiyama DHX16 DBP2 DDX16 KIAA0577 PRP2 HMPKETRGQPARAVDLVEEEsGAPGEEQRRWEEARLGAASL
O60664 S148 Sugiyama PLIN3 M6PRBP1 TIP47 KVsGAQEMVssAKDTVAtQLsEAVDATRGAVQSGVDKTKsV
O60664 S93 Sugiyama PLIN3 M6PRBP1 TIP47 AAVsGAQPILSKLEPQIAsAsEyAHRGLDKLEENLPILQQP
O60841 S66 Sugiyama EIF5B IF2 KIAA0741 KEKKKQDFDEDDILKELEELsLEAQGIKADREtVAVKPTEN
O60927 S74 Sugiyama PPP1R11 HCGV TCTE5 GRRssKCCCIyEKPRAFGEsstEsDEEEEEGCGHtHCVRGH
O75400 S938 Sugiyama PRPF40A FBP11 FLAF1 FNBP3 HIP10 HYPA HSPC225 SPKKKtGKDsGNWDtsGsELsEGELEKRRRtLLEQLDDDQ_
O75534 S74 Sugiyama CSDE1 D1S155E KIAA0885 NRU UNR SQYNGNLQDLKVGDDVEFEVsSDRRTGKPIAVKLVKIKQEI
O75821 S189 Sugiyama EIF3G EIF3S4 CPYKDtLGPMQKELAEQLGLstGEKEKLPGELEPVQAtQNK
O75821 S28 Sugiyama EIF3G EIF3S4 sKPsWADQVEEEGEDDKCVtsELLKGIPLAtGDtsPEPELL
O75821 T27 Sugiyama EIF3G EIF3S4 DsKPsWADQVEEEGEDDKCVtsELLKGIPLAtGDtsPEPEL
O95218 S188 Sugiyama ZRANB2 ZIS ZNF265 KLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRRSRSKSRS
O95630 S2 SIGNOR|iPTMNet STAMBP AMSH ___________________MsDHGDVSLPPEDRVRALSQLG
O95630 S243 SIGNOR|iPTMNet STAMBP AMSH TTVRPAKPPVVDRSLKPGALsNsEsIPTIDGLRHVVVPGRL
O95630 S245 SIGNOR|iPTMNet STAMBP AMSH VRPAKPPVVDRSLKPGALsNsEsIPTIDGLRHVVVPGRLCP
O95630 S247 SIGNOR|iPTMNet STAMBP AMSH PAKPPVVDRSLKPGALsNsEsIPTIDGLRHVVVPGRLCPQF
O95630 S48 SIGNOR|iPTMNet STAMBP AMSH NEDIPPRRYFRSGVEIIRMAsIYSEEGNIEHAFILYNKYIT
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00558 S393 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 GGDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDA
P00558 T394 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 GDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDAL
P04040 T28 Sugiyama CAT ASDQMQHWKEQRAAQKADVLttGAGNPVGDKLNVItVGPRG
P04075 S132 Sugiyama ALDOA ALDA GVVPLAGtNGEtttQGLDGLsERCAQYKKDGADFAKWRCVL
P04075 S17 Sugiyama ALDOA ALDA ____MPyQyPALtPEQKKELsDIAHRIVAPGKGILAADEst
P04075 S354 Sugiyama ALDOA ALDA ANsLACQGKytPsGQAGAAAsEsLFVsNHAy__________
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 T124 Sugiyama ALDOA ALDA VVGIKVDKGVVPLAGtNGEtttQGLDGLsERCAQYKKDGAD
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04083 S189 Sugiyama ANXA1 ANX1 LPC1 tsDtsGDFRNALLsLAKGDRsEDFGVNEDLADsDARALyEA
P04083 S201 Sugiyama ANXA1 ANX1 LPC1 LsLAKGDRsEDFGVNEDLADsDARALyEAGERRKGtDVNVF
P04083 T169 Sugiyama ANXA1 ANX1 LPC1 IRDINRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRs
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05388 S304 Sugiyama RPLP0 AttAAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD_______
P05388 S307 Sugiyama RPLP0 AAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD__________
P05455 S83 Sugiyama SSB TDFNVIVEALSKSKAELMEIsEDKTKIRRsPsKPLPEVTDE
P05787 S291 Sugiyama KRT8 CYK8 ANRsRAEAEsMyQIKyEELQsLAGKHGDDLRRTKTEISEMN
P06733 S40 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 VEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGK
P06733 T100 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 KKLNVtEQEKIDKLMIEMDGtENKsKFGANAILGVsLAVCK
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06733 T26 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 IHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEA
P06733 T41 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 EVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKG
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 T18 Sugiyama LDHB ___MATLKEKLIAPVAEEEAtVPNNKITVVGVGQVGMACAI
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07205 S393 Sugiyama PGK2 PGKB GGDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEA
P07205 T394 Sugiyama PGK2 PGKB GDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEAL
P07237 S88 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB GKLKAEGSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNG
P07237 T335 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB VRLITLEEEMTKyKPEsEELtAERItEFCHRFLEGKIKPHL
P07237 T85 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB KAAGKLKAEGSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFF
P07355 S184 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK
P07437 S115 Sugiyama TUBB TUBB5 OK/SW-cl.56 sGAGNNWAKGHytEGAELVDsVLDVVRKEAESCDCLQGFQL
P07437 T107 Sugiyama TUBB TUBB5 OK/SW-cl.56 PDNFVFGQsGAGNNWAKGHytEGAELVDsVLDVVRKEAESC
P07737 S30 Sugiyama PFN1 NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07737 S85 Sugiyama PFN1 tLGGQKCsVIRDsLLQDGEFsMDLRtKstGGAPTFNVtVtK
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900 S231 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA SQFIGyPITLFVEKERDKEVsDDEAEEKEDKEEEKEKEEKE
P07900 S263 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA EEKEKEEKEsEDKPEIEDVGsDEEEEKKDGDKKKKKKIKEK
P07900 S391 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MDNCEELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P07900 S52 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900 T195 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DTGEPMGRGTKVILHLKEDQtEyLEERRIKEIVKKHSQFIG
P07900 T305 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IDQEELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLA
P07900 T317 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA WtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08195 S598 Sugiyama SLC3A2 MDU1 LQASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEP
P08195 T275 Sugiyama SLC3A2 MDU1 KVKGLVLGPIHKNQKDDVAQtDLLQIDPNFGsKEDFDsLLQ
P08195 T599 Sugiyama SLC3A2 MDU1 QASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEPH
P08238 S383 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MDSCDELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P08238 S468 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238 S470 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB RLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItGEs
P08238 T190 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
P08238 T297 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IDQEELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLA
P08238 T309 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB WtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08238 T467 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB NRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyIt
P08238 Y301 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB ELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHF
P08238 Y472 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB sELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItGEsKE
P08708 S89 Sugiyama RPS17 RPS17L ISIKLQEEERERRDNyVPEVsALDQEIIEVDPDtKEMLKLL
P08758 T10 Sugiyama ANXA5 ANX5 ENX2 PP4 ___________MAQVLRGtVtDFPGFDERADAEtLRKAMKG
P09382 T58 Sugiyama LGALS1 DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P09972 S132 Sugiyama ALDOC ALDC GVVPLAGtDGEtttQGLDGLsERCAQYKKDGADFAKWRCVL
P09972 T125 Sugiyama ALDOC ALDC VGIKVDKGVVPLAGtDGEtttQGLDGLsERCAQYKKDGADF
P0CG38 S1065 Sugiyama POTEI ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
P0CG39 S1028 Sugiyama POTEJ ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
P10809 S67 Sugiyama HSPD1 HSP60 LADAVAVTMGPKGRtVIIEQsWGsPKVTKDGVtVAKsIDLK
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11586 T128 Sugiyama MTHFD1 MTHFC MTHFD SINTEEVINAIAPEKDVDGLtsINAGKLARGDLNDCFIPCt
P12004 S261 Sugiyama PCNA IADMGHLKyyLAPKIEDEEGs____________________
P12956 S27 Sugiyama XRCC6 G22P1 YYKtEGDEEAEEEQEENLEAsGDyKYsGRDsLIFLVDASKA
P13489 S290 Sugiyama RNH1 PRI RNH AKGCGDLCRVLRAKESLKELsLAGNELGDEGARLLCETLLE
P13489 T176 Sugiyama RNH1 PRI RNH AASCEPLASVLRAKPDFKELtVsNNDINEAGVRVLCQGLKD
P13639 S584 Sugiyama EEF2 EF2 DHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyM
P13639 S587 Sugiyama EEF2 EF2 CIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKAR
P13639 T5 Sugiyama EEF2 EF2 ________________MVNFtVDQIRAIMDKKANIRNMsVI
P13667 S379 Sugiyama PDIA4 ERP70 ERP72 QPEKFQSKYEPRSHMMDVQGstQDsAIKDFVLKyALPLVGH
P13667 S468 Sugiyama PDIA4 ERP70 ERP72 ytFAIADEEDyAGEVKDLGLsEsGEDVNAAILDEsGKKFAM
P13667 S470 Sugiyama PDIA4 ERP70 ERP72 FAIADEEDyAGEVKDLGLsEsGEDVNAAILDEsGKKFAMEP
P14618 S287 Sugiyama PKM OIP3 PK2 PK3 PKM2 IIsKIENHEGVRRFDEILEAsDGIMVARGDLGIEIPAEKVF
P14618 S346 Sugiyama PKM OIP3 PK2 PK3 PKM2 CAtQMLEsMIKKPRPTRAEGsDVANAVLDGADCIMLSGEtA
P14625 S439 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 TDDFHDMMPKyLNFVKGVVDsDDLPLNVsREtLQQHKLLKV
P14625 T522 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 NRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQDKIyFMA
P15311 S535 Sugiyama EZR VIL2 EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15311 S539 Sugiyama EZR VIL2 TEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNENMR
P15531 S120 Sugiyama NME1 NDPKA NM23 KPGtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELV
P15531 S122 Sugiyama NME1 NDPKA NM23 GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P17987 S551 Sugiyama TCP1 CCT1 CCTA IKLHPESKDDKHGsyEDAVHsGALND_______________
P18206 S726 Sugiyama VCL VEKMTGLVDEAIDtKsLLDAsEEAIKKDLDKCKVAMANIQP
P18669 T146 Sugiyama PGAM1 PGAMA CDABP0006 MEPDHPFysNIsKDRRyADLtEDQLPsCEsLKDtIARALPF
P20810 S373 Sugiyama CAST LPEPEEKPKPRsEsELIDELsEDFDRsECKEKPSKPTEKTE
P21291 S192 Sugiyama CSRP1 CSRP CYRP AKNFGPKGFGFGQGAGALVHsE___________________
P22314 S46 Sugiyama UBA1 A1S9T UBE1 AQsVLsEVPSVPTNGMAKNGsEADIDEGLysRQLyVLGHEA
P23396 T242 Sugiyama RPS3 OK/SW-cl.26 PIsEQKGGKPEPPAMPQPVPtA___________________
P23528 T63 Sugiyama CFL1 CFL DKKNIILEEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyA
P25788 S250 Sugiyama PSMA3 HC8 PSC8 KDIREEAEKyAKEsLKEEDEsDDDNM_______________
P26038 S527 Sugiyama MSN ERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHAE
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P26373 T148 Sugiyama RPL13 BBC1 OK/SW-cl.46 PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373 T151 Sugiyama RPL13 BBC1 OK/SW-cl.46 PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P26639 S39 Sugiyama TARS1 TARS PIGAGEEKQKEGGKKKNKEGsGDGGRAELNPWPEyIytRLE
P27348 S145 Sugiyama YWHAQ YFRyLAEVACGDDRKQtIDNsQGAyQEAFDIsKKEMQPTHP
P27348 S37 Sugiyama YWHAQ ERyDDMAtCMKAVtEQGAELsNEERNLLsVAyKNVVGGRRS
P27348 S45 Sugiyama YWHAQ CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27695 T19 Sugiyama APEX1 APE APE1 APEX APX HAP1 REF1 __MPKRGKKGAVAEDGDELRtEPEAKKSKTAAKKNDKEAAG
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27816 S643 Sugiyama MAP4 IsPEtVTGtGKKCsLPAEEDsVLEKLGERKPCNsQPSELSS
P28066 S174 Sugiyama PSMA5 FHMDPsGtFVQCDARAIGsAsEGAQssLQEVyHKSMTLKEA
P28066 S179 Sugiyama PSMA5 sGtFVQCDARAIGsAsEGAQssLQEVyHKSMTLKEAIKSSL
P29401 S190 Sugiyama TKT ASIYKLDNLVAILDINRLGQsDPAPLQHQMDIyQKRCEAFG
P29401 S295 Sugiyama TKT ysQIQsKKKILAtPPQEDAPsVDIANIRMPsLPsyKVGDKI
P29401 T454 Sugiyama TKT LAMFRsVPtstVFyPsDGVAtEKAVELAANTKGICFIRTsR
P29692 S70 Sugiyama EEF1D EF1D IARARENIQKsLAGssGPGAssGtsGDHGELVVRIAsLEVE
P30041 T49 Sugiyama PRDX6 AOP2 KIAA0106 LGDSWGILFSHPRDFtPVCttELGRAAKLAPEFAKRNVKLI
P30043 T199 Sugiyama BLVRB FLR SCAN HDLGHFMLRCLttDEyDGHstyPsHQyQ_____________
P30048 S86 Sugiyama PRDX3 AOP1 TQHAPYFKGTAVVNGEFKDLsLDDFKGKYLVLFFYPLDFTF
P30050 S157 Sugiyama RPL12 QsVGCNVDGRHPHDIIDDINsGAVECPAs____________
P30101 T485 Sugiyama PDIA3 ERP57 ERP60 GRP58 KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P31943 S63 Sugiyama HNRNPH1 HNRPH HNRPH1 IRFIYTREGRPsGEAFVELEsEDEVKLALKKDRETMGHRyV
P31946 S39 Sugiyama YWHAB ERyDDMAAAMKAVtEQGHELsNEERNLLsVAyKNVVGARRS
P31946 S47 Sugiyama YWHAB AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947 S37 Sugiyama SFN HME1 ERyEDMAAFMKGAVEKGEELsCEERNLLsVAyKNVVGGQRA
P31947 S45 Sugiyama SFN HME1 FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P34932 S31 Sugiyama HSPA4 APG2 HSPH2 QSCYVAVARAGGIETIANEysDRCtPACIsFGPKNRSIGAA
P34932 S414 Sugiyama HSPA4 APG2 HSPH2 ITDVVPYPISLRWNsPAEEGssDCEVFSKNHAAPFSKVLTF
P35269 S217 Sugiyama GTF2F1 RAP74 RGRRKASELRIHDLEDDLEMssDAsDAsGEEGGRVPKAKKK
P35579 S1943 Sugiyama MYH9 RGDLPFVVPRRMARKGAGDGsDEEVDGKADGAEAKPAE___
P35579 T1745 Sugiyama MYH9 RRLEARIAQLEEELEEEQGNtELINDRLKKANLQIDQINtD
P35579 T1904 Sugiyama MYH9 EEAQRANAsRRKLQRELEDAtEtADAMNREVssLKNKLRRG
P35580 T1911 Sugiyama MYH10 EEATRANASRRKLQRELDDAtEANEGLSREVSTLKNRLRRG
P35659 S231 Sugiyama DEK SGMARKAKRTKCPEILsDEsssDEDEKKNKEEssDDEDKEs
P36871 S477 Sugiyama PGM1 KQFSANDKVYtVEKADNFEysDPVDGsIsRNQGLRLIFTDG
P38646 T94 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 QAKVLENAEGARttPsVVAFtADGERLVGMPAKRQAVtNPN
P41091 T21 Sugiyama EIF2S3 EIF2G MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
P41227 S216 Sugiyama NAA10 ARD1 ARD1A TE2 EEKGLAAEDsGGDsKDLsEVsEtTEstDVKDssEAsDsAs_
P43121 T298 Sugiyama MCAM MUC18 PPPHFSISKQNPstREAEEEttNDNGVLVLEPARKEHSGRY
P43121 T299 Sugiyama MCAM MUC18 PPHFSISKQNPstREAEEEttNDNGVLVLEPARKEHSGRYE
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46783 S146 Sugiyama RPS10 TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P48643 S270 Sugiyama CCT5 CCTE KIAA0098 ILTCPFEPPKPKTKHKLDVtsVEDyKALQKYEKEKFEEMIQ
P48643 T269 Sugiyama CCT5 CCTE KIAA0098 AILTCPFEPPKPKTKHKLDVtsVEDyKALQKYEKEKFEEMI
P49327 S1129 Sugiyama FASN FAS QQVPILEKFCFtPHTEEGCLsERAALQEELQLCKGLVQALQ
P49327 S2198 Sugiyama FASN FAS EVRQLTLRKLQELSSKADEAsELACPtPKEDGLAQQQtQLN
P49588 T481 Sugiyama AARS1 AARS DLIMLDIYAIEELRARGLEVtDDsPKYNYHLDSSGSYVFEN
P51003 S672 Sugiyama PAPOLA PAP tssPHKEEsPKKTKTEEDETsEDANCLALsGHDKTEAKEQL
P52597 S107 Sugiyama HNRNPF HNRPF KSHRTEMDWVLKHsGPNsADsANDGFVRLRGLPFGCTKEEI
P52907 S106 Sugiyama CAPZA1 RFLDPRNKISFKFDHLRKEAsDPQPEEADGGLKsWREsCDs
P53675 S460 Sugiyama CLTCL1 CLH22 CLTCL CLTD LQQGRKQLLEKWLKEDKLECsEELGDLVKTTDPMLALSVYL
P53999 S118 Sugiyama SUB1 PC4 RPO2TC1 PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P53999 S19 Sugiyama SUB1 PC4 RPO2TC1 __MPKSKELVsssssGsDsDsEVDKKLKRKKQVAPEKPVKK
P54578 S492 Sugiyama USP14 TGT WHIAYVLLYGPRRVEIMEEEsEQ__________________
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P55060 S366 Sugiyama CSE1L CAS XPO2 KVIVPNMEFRAADEEAFEDNsEEyIRRDLEGsDIDTRRRAA
P57721 S82 Sugiyama PCBP3 PCBP3-OT1 PCBP3OT GKKGETVKKMREESGARINIsEGNCPERIVTITGPTDAIFK
P58546 T108 Sugiyama MTPN LSKGADKTVKGPDGLTAFEAtDNQAIKALLQ__________
P60174 T38 Sugiyama TPI1 TPI RKQsLGELIGtLNAAKVPADtEVVCAPPtAyIDFARQKLDP
P60709 S365 Sugiyama ACTB ILAsLstFQQMWISKQEyDEsGPsIVHRKCF__________
P60709 T106 Sugiyama ACTB WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P60709 T249 Sugiyama ACTB tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P60709 T318 Sugiyama ACTB VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P60709 Y240 Sugiyama ACTB ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P61221 S218 Sugiyama ABCE1 RLI RNASEL1 RNASELI RNS4I OK/SW-cl.40 AIVCQQLDLTHLKERNVEDLsGGELQRFACAVVCIQKADIF
P61247 S263 Sugiyama RPS3A FTE1 MFTL GDEtGAKVERADGyEPPVQEsV___________________
P61981 S38 Sugiyama YWHAG ERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKNVVGARRS
P61981 S46 Sugiyama YWHAG AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P61981 T31 Sugiyama YWHAG ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62258 S46 Sugiyama YWHAE SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62269 T60 Sugiyama RPS18 D6S218E YAHVVLRKADIDLTKRAGELtEDEVERVItIMQNPRQYKIP
P62280 T54 Sugiyama RPS11 PRYYKNIGLGFKtPKEAIEGtyIDKKCPFTGNVsIRGRILs
P62736 T251 Sugiyama ACTA2 ACTSA ACTVS GIG46 tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P62736 T320 Sugiyama ACTA2 ACTSA ACTVS GIG46 VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P62736 Y242 Sugiyama ACTA2 ACTSA ACTVS GIG46 ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62826 S150 Sugiyama RAN ARA24 OK/SW-cl.81 KVKAKsIVFHRKKNLQyyDIsAKSNyNFEKPFLWLARKLIG
P62942 T7 Sugiyama FKBP1A FKBP1 FKBP12 ______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P63104 S145 Sugiyama YWHAZ YYRyLAEVAAGDDKKGIVDQsQQAyQEAFEIsKKEMQPTHP
P63104 S28 Sugiyama YWHAZ QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104 S37 Sugiyama YWHAZ ERyDDMAACMKsVtEQGAELsNEERNLLsVAyKNVVGARRs
P63104 S45 Sugiyama YWHAZ CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63151 S409 Sugiyama PPP2R2A RTVLKPRKVCASGKRKKDEIsVDsLDFNKKILHTAWHPKEN
P63167 S14 Sugiyama DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1 _______MCDRKAVIKNADMsEEMQQDsVECAtQALEKYNI
P63261 S365 Sugiyama ACTG1 ACTG ILAsLstFQQMWISKQEyDEsGPsIVHRKCF__________
P63261 T106 Sugiyama ACTG1 ACTG WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P63261 T249 Sugiyama ACTG1 ACTG tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P63261 T318 Sugiyama ACTG1 ACTG VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P63261 Y240 Sugiyama ACTG1 ACTG ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63267 T250 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P63267 T319 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P63267 Y241 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P67809 T108 Sugiyama YBX1 NSEP1 YB1 QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P68032 T251 Sugiyama ACTC1 ACTC tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68032 T320 Sugiyama ACTC1 ACTC VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68032 Y242 Sugiyama ACTC1 ACTC ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68133 T251 Sugiyama ACTA1 ACTA tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68133 T320 Sugiyama ACTA1 ACTA VMSGGTTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68133 Y242 Sugiyama ACTA1 ACTA ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68363 S439 Sugiyama TUBA1B SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
P68363 T73 Sugiyama TUBA1B FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363 T80 Sugiyama TUBA1B KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
P78371 S150 Sugiyama CCT2 99D8.1 CCTB WREATKAAREALLssAVDHGsDEVKFRQDLMNIAGTTLssK
P84098 T29 Sugiyama RPL19 RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
Q00341 S35 Sugiyama HDLBP HBP VGL HRSGLVPQQIKVAtLNsEEEsDPPtyKDAFPPLPEKAACLE
Q00610 S460 Sugiyama CLTC CLH17 CLTCL2 KIAA0034 LQQGRKQLLEKWLKEDKLECsEELGDLVKSVDPTLALSVYL
Q01105 S166 Sugiyama SET yFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQT
Q01105 T169 Sugiyama SET NKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQNK
Q04637 S1430 Sugiyama EIF4G1 EIF4F EIF4G EIF4GI GQDIGAFVAEQKVEyTLGEEsEAPGQRALPsEELNRQLEKL
Q04917 S150 Sugiyama YWHAH YWHA1 YYRYLAEVASGEKKNsVVEAsEAAyKEAFEISKEQMQPTHP
Q04917 S46 Sugiyama YWHAH YWHA1 AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q06830 S152 Sugiyama PRDX1 PAGA PAGB TDPX2 IIDDKGILRQItVNDLPVGRsVDEtLRLVQAFQFtDKHGEV
Q08J23 T733 Sugiyama NSUN2 SAKI TRM4 EGVILtNEsAAstGQPDNDVtEGQRAGEPNsPDAEEANsPD
Q12792 T348 Sugiyama TWF1 PTK9 GPAGKRGIRRLIRGPAEtEAttD__________________
Q12792 T349 Sugiyama TWF1 PTK9 PAGKRGIRRLIRGPAEtEAttD___________________
Q12874 S482 Sugiyama SF3A3 SAP61 LKLQKASERWQPDtEEEyEDssGNVVNKKTYEDLKRQGLL_
Q12874 S483 Sugiyama SF3A3 SAP61 KLQKASERWQPDtEEEyEDssGNVVNKKTYEDLKRQGLL__
Q12906 T300 Sugiyama ILF3 DRBF MPHOSPH4 NF90 ASGIVMPDGSGIYDPCEKEAtDAIGHLDRQQREDItQsAQH
Q13283 T241 Sugiyama G3BP1 G3BP ETAPEDAQKsssPAPADIAQtVQEDLRtFsWAsVtsKNLPP
Q13371 S25 Sugiyama PDCL PHLOP1 PhLP1 DDKLLGEKLQyyysssEDEDsDHEDKDRGRCAPAsssVPAE
Q13428 S765 Sugiyama TCOF1 GKTGPTVTQVKAEKQEDsEssEEEsDSEEAAAsPAQVKTSV
Q13442 S63 Sugiyama PDAP1 HASPP28 GGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGVEGLIDI
Q13509 S115 Sugiyama TUBB3 TUBB4 SGAGNNWAKGHytEGAELVDsVLDVVRKECENCDCLQGFQL
Q13509 T107 Sugiyama TUBB3 TUBB4 PDNFIFGQSGAGNNWAKGHytEGAELVDsVLDVVRKECENC
Q13541 S112 Sugiyama EIF4EBP1 EAsQsHLRNsPEDKRAGGEEsQFEMDI______________
Q13547 S421 Sugiyama HDAC1 RPD3L1 PDKRIsICssDKRIACEEEFsDsEEEGEGGRKNsSNFKKAK
Q13561 T114 Sugiyama DCTN2 DCTN50 GVKETPQQKYQRLLHEVQELtTEVEKIKTTVKEsATEEKLt
Q13873 S375 Sugiyama BMPR2 PPH1 SMRLTGNRLVRPGEEDNAAIsEVGtIRYMAPEVLEGAVNLR
Q13873 S681 Sugiyama BMPR2 PPH1 EDLETNKLDPKEVDKNLKEssDENLMEHsLKQFSGPDPLSS
Q13873 S689 Sugiyama BMPR2 PPH1 DPKEVDKNLKEssDENLMEHsLKQFSGPDPLSSTSSSLLyP
Q13885 S115 Sugiyama TUBB2A TUBB2 sGAGNNWAKGHytEGAELVDsVLDVVRKESESCDCLQGFQL
Q13885 T107 Sugiyama TUBB2A TUBB2 PDNFVFGQsGAGNNWAKGHytEGAELVDsVLDVVRKESESC
Q14152 S1256 Sugiyama EIF3A EIF3S10 KIAA0139 EDRFRRPRDEGGWRRGPAEEsssWRDssRRDDRDRDDRRRE
Q14566 T321 Sugiyama MCM6 CCVAPTNPRFGGKELRDEEQtAEsIKNQMTVKEWEKVFEMs
Q14568 S52 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14677 S166 Sugiyama CLINT1 ENTH EPN4 EPNR KIAA0171 REERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSKWDE
Q14978 S90 Sugiyama NOLC1 KIAA0035 NS5ATP13 ANGPVAKKAKKKAsssDsEDssEEEEEVQGPPAKKAAVPAK
Q14C86 S576 Sugiyama GAPVD1 GAPEX5 KIAA1521 RAP6 HGKPDKTLRFSLCsDNLEGIsEGPSNRSNSVSSLDLEGESV
Q15007 S271 Sugiyama WTAP KIAA0105 TSRTTASEPVEQSEATSKDCsRLtNGPsNGsssRQRtsGSG
Q15007 S278 Sugiyama WTAP KIAA0105 EPVEQSEATSKDCsRLtNGPsNGsssRQRtsGSGFHREGNt
Q15007 S281 Sugiyama WTAP KIAA0105 EQSEATSKDCsRLtNGPsNGsssRQRtsGSGFHREGNtTED
Q15007 S282 Sugiyama WTAP KIAA0105 QSEATSKDCsRLtNGPsNGsssRQRtsGSGFHREGNtTEDD
Q15007 S283 Sugiyama WTAP KIAA0105 SEATSKDCsRLtNGPsNGsssRQRtsGSGFHREGNtTEDDF
Q15007 T274 Sugiyama WTAP KIAA0105 TTASEPVEQSEATSKDCsRLtNGPsNGsssRQRtsGSGFHR
Q15084 T166 Sugiyama PDIA6 ERP5 P5 TXNDC7 YSSGKQGRSDsSSKKDVIELtDDsFDKNVLDSEDVWMVEFY
Q15293 T100 Sugiyama RCN1 RCN sKERLGKIVDRIDNDGDGFVttEELKtWIKRVQKRyIFDNV
Q15365 S50 Sugiyama PCBP1 GKKGESVKRIREEsGARINIsEGNCPERIItLTGPTNAIFK
Q15366 S50 Sugiyama PCBP2 GKKGESVKKMREESGARINIsEGNCPERIITLAGPTNAIFK
Q15796 S464 GPS6|ELM|iPTMNet|EPSD|PSP SMAD2 MADH2 MADR2 GPLQWLDKVLTQMGsPsVRCssMs_________________
Q15796 S465 GPS6|ELM|iPTMNet|EPSD|PSP SMAD2 MADH2 MADR2 PLQWLDKVLTQMGsPsVRCssMs__________________
Q15796 S467 GPS6|ELM|iPTMNet|EPSD|PSP SMAD2 MADH2 MADR2 QWLDKVLTQMGsPsVRCssMs____________________
Q15797 S462 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP SMAD1 BSP1 MADH1 MADR1 GPLQWLDKVLTQMGsPHNPIssVs_________________
Q15797 S463 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP SMAD1 BSP1 MADH1 MADR1 PLQWLDKVLTQMGsPHNPIssVs__________________
Q15797 S465 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP SMAD1 BSP1 MADH1 MADR1 QWLDKVLTQMGsPHNPIssVs____________________
Q16576 T10 Sugiyama RBBP7 RBAP46 ___________MAsKEMFEDtVEERVINEEYKIWKKNTPFL
Q2T9J0 S171 Sugiyama TYSND1 FGDEAAEQWRFSSAARDDEVsEDEEADQLRALGWFALLGVR
Q2VIR3 T21 Sugiyama EIF2S3B MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q562R1 T250 Sugiyama ACTBL2 RAAAssSPERsyELPDGQVItIGNERFRCPEAIFQPSFLGI
Q562R1 Y241 Sugiyama ACTBL2 ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q58FF6 T165 Sugiyama HSP90AB4P DHGEPIDRDTKVILHLKEDQtEyLEERWVKEVVKKHPQFIG
Q58FF7 T169 Sugiyama HSP90AB3P HSP90BC DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
Q66LE6 S415 Sugiyama PPP2R2D KIAA1541 RASLKPRKVCTGGKRRKDEIsVDsLDFNKKILHTAWHPVDN
Q6NVY1 T368 Sugiyama HIBCH AVLIDKDQSPKWKPADLKEVtEEDLNNHFKSLGsSDLKF__
Q6PKG0 S631 Sugiyama LARP1 KIAA0731 LARP EEMEQMDGRKNtFtAWsDEEsDyEIDDRDVNKILIVtQtPH
Q6S8J3 S1065 Sugiyama POTEE A26C1A POTE2 ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
Q6S8J3 T949 Sugiyama POTEE A26C1A POTE2 tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q6S8J3 Y940 Sugiyama POTEE A26C1A POTE2 ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q6UXH1 S295 Sugiyama CRELD2 UNQ185/PRO211 KECISGYAREHGQCADVDECsLAEKtCVRKNENCYNTPGSY
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q71U36 S439 Sugiyama TUBA1A TUBA3 SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
Q71U36 T73 Sugiyama TUBA1A TUBA3 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36 T80 Sugiyama TUBA1A TUBA3 KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q7LDG7 T4 Sugiyama RASGRP2 CDC25L MCG7 _________________MAGtLDLDKGCTVEELLRGCIEAF
Q7Z460 S246 Sugiyama CLASP1 KIAA0622 MAST1 VQKSGNMIQSANDKNFDDEDsVDGNRPssAsStSSKAPPSS
Q86TG7 S10 Sugiyama PEG10 EDR KIAA1051e MAR2 MART2 MEF3L1 RGAG3 ___________MTERRRDELsEEINNLREKVMKQSEENNNL
Q8NBJ5 S616 Sugiyama COLGALT1 GLT25D1 PSEC0241 EQQALSREAKNsDVLQsPLDsAARDEL______________
Q8NE71 S595 Sugiyama ABCF1 ABC50 TKEALTRKQQKCRRKNQDEEsQEAPELLKRPKEYTVRFTFP
Q8NHW5 S304 Sugiyama RPLP0P6 DTTAAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD_______
Q8NHW5 S307 Sugiyama RPLP0P6 AAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD__________
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8TBF4 S216 Sugiyama ZCRB1 DDSRRPRIKKstYFsDEEELsD___________________
Q8WUM4 T464 Sugiyama PDCD6IP AIP1 ALIX KIAA1375 LQRNREILDEsLRLLDEEEAtDNDLRAKFKERWQRtPSNEL
Q92769 S422 Sugiyama HDAC2 PDKRIsIRAsDKRIACDEEFsDsEDEGEGGRRNVADHKKGA
Q92890 T210 Sugiyama UFD1 UFD1L DFDAPLGYKEPERQVQHEEstEGEADHsGyAGELGFRAFsG
Q96A49 S313 Sugiyama SYAP1 PRO3113 EMEQLVLDKKQEEtAVLEEDsADWEKELQQELQEyEVVtES
Q96A49 T306 Sugiyama SYAP1 PRO3113 NQEDLRKEMEQLVLDKKQEEtAVLEEDsADWEKELQQELQE
Q96D46 T470 Sugiyama NMD3 CGI-07 EAIRKNVNIyRDsAIPVEsDtDDEGAPRISLAEMLEDLHIs
Q96HE7 S143 Sugiyama ERO1A ERO1L UNQ434/PRO865 EANNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSD
Q96HE7 S145 Sugiyama ERO1A ERO1L UNQ434/PRO865 NNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSDNF
Q96HE7 T148 Sugiyama ERO1A ERO1L UNQ434/PRO865 IEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSDNFCEA
Q96IR7 S365 Sugiyama HPDL GLOXD1 GATGFGQGNIRALWQsVQEQsARSQEA______________
Q96QK1 T763 Sugiyama VPS35 MEM3 TCCCTA00141 LNQLIQKIREDLPNLEssEEtEQINKHFHNtLEHLRLRREs
Q99497 S57 Sugiyama PARK7 GLAGKDPVQCsRDVVICPDAsLEDAKKEGPyDVVVLPGGNL
Q99613 S39 Sugiyama EIF3C EIF3S8 GEELVTKPVGGNyGKQPLLLsEDEEDTKRVVRSAKDKRFEE
Q99614 S90 Sugiyama TTC1 TPR1 FEEEPGADKVENKsNEDVNssELDEEyLIELEKNMSDEEKQ
Q99733 S121 Sugiyama NAP1L4 NAP2 PLFDKRREFItGDVEPtDAEsEWHsENEEEEKLAGDMKSKV
Q99733 T117 Sugiyama NAP1L4 NAP2 ALyQPLFDKRREFItGDVEPtDAEsEWHsENEEEEKLAGDM
Q99832 T351 Sugiyama CCT7 CCTH NIP7-1 QtSVNALSADVLGRCQVFEEtQIGGERyNFFtGCPKAKTCt
Q9BQE3 T73 Sugiyama TUBA1C TUBA6 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3 T80 Sugiyama TUBA1C TUBA6 KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q9BVA1 S115 Sugiyama TUBB2B sGAGNNWAKGHytEGAELVDsVLDVVRKESESCDCLQGFQL
Q9BVA1 T107 Sugiyama TUBB2B PDNFVFGQsGAGNNWAKGHytEGAELVDsVLDVVRKESESC
Q9BW91 S343 Sugiyama NUDT9 NUDT10 PSEC0099 UNQ3012/PRO9771 SHSQFIKLVAEKRDAHWSEDsEADCHAL_____________
Q9BYX7 S365 Sugiyama POTEKP ACTBL3 FKSG30 ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
Q9BYX7 T249 Sugiyama POTEKP ACTBL3 FKSG30 MAASSSSVEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q9BYX7 Y240 Sugiyama POTEKP ACTBL3 FKSG30 ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9C0C2 S804 Sugiyama TNKS1BP1 KIAA1741 TAB182 EGSTREWASRCGIGQEEMEAsSsQDQSKVSAPGVLTAQDRV
Q9C0C2 S806 Sugiyama TNKS1BP1 KIAA1741 TAB182 STREWASRCGIGQEEMEAsSsQDQSKVSAPGVLTAQDRVVG
Q9C0C2 T1323 Sugiyama TNKS1BP1 KIAA1741 TAB182 ELGVGQMDWGNNLGLRDLEVtCDPDsGGsQGLRGCGVGQMD
Q9HCC0 S256 Sugiyama MCCC2 MCCB QGTIFLAGPPLVKAATGEEVsAEDLGGADLHCRKSGVSDHW
Q9NQ39 S157 Sugiyama RPS10P5 RPS10L TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9NR28 S230 Sugiyama DIABLO SMAC EAQIEELRQKTQEEGEERAEsEQEAyLRED___________
Q9UHX1 S558 Sugiyama PUF60 FIR ROBPI SIAHBP1 AGRKVVAEVYDQERFDNsDLsA___________________
Q9UI30 S125 Sugiyama TRMT112 AD-001 HSPC152 HSPC170 RMFPISRGIPNMLLsEEEtEs____________________
Q9UKK9 S24 Sugiyama NUDT5 NUDIX5 HSPC115 QEPtEssQNGKQyIISEELIsEGKWVKLEKTTYMDPTGKtR
Q9UNF1 S52 Sugiyama MAGED2 BCG1 TVTQNVEVPEtPKASKALEVsEDVKVSKASGVSKAtEVsKt
Q9UPR3 S475 Sugiyama SMG5 EST1B KIAA1089 RLSCLRRRRHPPKVGDDSDLsEGFEsDSSHDSARASEGSDS
Q9Y265 S434 Sugiyama RUVBL1 INO80H NMP238 TIP49 TIP49A NLLAKINGKDSIEKEHVEEIsELFyDAKSSAKILADQQDKY
Q9Y2B0 S116 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 IDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKFA
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2T7 T143 Sugiyama YBX2 CSDA3 MSY2 QtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEATNVTGP
Q9Y3U8 S91 Sugiyama RPL36 KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Q9Y4L1 S763 Sugiyama HYOU1 GRP170 HSPH4 ORP150 LEAFIFEtQDKLyQPEyQEVsTEEQREEISGKLSAASTWLE
Q9Y5S9 S56 Sugiyama RBM8A RBM8 HSPC114 MDS014 KGRGFGsEEGsRARMREDyDsVEQDGDEPGPQRSVEGWILF
Q9Y5S9 Y54 Sugiyama RBM8A RBM8 HSPC114 MDS014 KRKGRGFGsEEGsRARMREDyDsVEQDGDEPGPQRSVEGWI
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Chromatin organization R-HSA-4839726 5.630715e-10 9.249 0 0
Chromatin modifying enzymes R-HSA-3247509 1.452498e-09 8.838 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.728849e-07 6.762 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.781315e-07 6.749 0 0
Cell Cycle R-HSA-1640170 1.098241e-06 5.959 0 0
Metabolism of RNA R-HSA-8953854 2.079898e-06 5.682 0 0
Gene expression (Transcription) R-HSA-74160 3.227591e-06 5.491 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 9.314025e-06 5.031 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.603276e-05 4.584 0 0
Cell Cycle, Mitotic R-HSA-69278 2.674627e-05 4.573 0 0
mRNA Splicing - Major Pathway R-HSA-72163 3.775485e-05 4.423 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 4.168880e-05 4.380 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 5.626502e-05 4.250 0 0
mRNA Splicing R-HSA-72172 6.720386e-05 4.173 0 0
MITF-M-dependent gene expression R-HSA-9856651 8.059961e-05 4.094 0 0
Apoptotic execution phase R-HSA-75153 8.991614e-05 4.046 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.797109e-04 3.745 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.903560e-04 3.720 0 0
Signaling by ALK in cancer R-HSA-9700206 1.903560e-04 3.720 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.903756e-04 3.720 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.318101e-04 3.635 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 3.053314e-04 3.515 0 0
RNA Polymerase II Transcription R-HSA-73857 3.086490e-04 3.511 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.303270e-04 3.481 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 4.052109e-04 3.392 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 5.899218e-04 3.229 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 7.500635e-04 3.125 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 7.500635e-04 3.125 0 0
HDMs demethylate histones R-HSA-3214842 7.500635e-04 3.125 0 0
Regulation of TP53 Activity R-HSA-5633007 9.102935e-04 3.041 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.102662e-03 2.958 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.235227e-03 2.908 0 0
Deubiquitination R-HSA-5688426 1.324806e-03 2.878 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.404626e-03 2.852 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.495099e-03 2.825 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.687160e-03 2.773 0 0
Signaling by EGFR R-HSA-177929 1.731060e-03 2.762 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.744261e-03 2.758 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.744261e-03 2.758 0 0
M Phase R-HSA-68886 1.808202e-03 2.743 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.871741e-03 2.728 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.039275e-03 2.691 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.274951e-03 2.643 0 0
PECAM1 interactions R-HSA-210990 2.311822e-03 2.636 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.598554e-03 2.585 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.601129e-03 2.585 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.691764e-03 2.570 0 0
Ephrin signaling R-HSA-3928664 3.058513e-03 2.514 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.065343e-03 2.514 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 3.197393e-03 2.495 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.253070e-03 2.488 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 3.305949e-03 2.481 0 0
EPH-Ephrin signaling R-HSA-2682334 3.439416e-03 2.464 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.795864e-03 2.421 0 0
PKMTs methylate histone lysines R-HSA-3214841 3.894027e-03 2.410 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.779153e-03 2.423 0 0
G0 and Early G1 R-HSA-1538133 3.928821e-03 2.406 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 4.006609e-03 2.397 0 0
Cell Cycle Checkpoints R-HSA-69620 4.167441e-03 2.380 0 0
Signaling by VEGF R-HSA-194138 4.488740e-03 2.348 0 0
DNA Repair R-HSA-73894 4.920560e-03 2.308 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 4.964416e-03 2.304 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 5.204439e-03 2.284 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 5.204439e-03 2.284 0 0
MTOR signalling R-HSA-165159 5.500391e-03 2.260 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 5.813151e-03 2.236 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 5.771160e-03 2.239 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 6.774335e-03 2.169 0 0
Signaling by ERBB2 R-HSA-1227986 7.128401e-03 2.147 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 7.725154e-03 2.112 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 7.725154e-03 2.112 0 0
Signaling by Hippo R-HSA-2028269 7.725154e-03 2.112 0 0
Regulation of KIT signaling R-HSA-1433559 8.766364e-03 2.057 0 0
Cellular response to heat stress R-HSA-3371556 8.844254e-03 2.053 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 9.468097e-03 2.024 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 9.468097e-03 2.024 0 0
Nucleotide Excision Repair R-HSA-5696398 9.151327e-03 2.039 0 0
Mitotic Prometaphase R-HSA-68877 9.531133e-03 2.021 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 9.899871e-03 2.004 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 9.899871e-03 2.004 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.100968e-02 1.958 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 1.131011e-02 1.947 0 0
Generic Transcription Pathway R-HSA-212436 1.164527e-02 1.934 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.189260e-02 1.925 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.264921e-02 1.898 0 0
Integrin signaling R-HSA-354192 1.226134e-02 1.911 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.475524e-02 1.831 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.475524e-02 1.831 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.475524e-02 1.831 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.475524e-02 1.831 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.475524e-02 1.831 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.475524e-02 1.831 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.475524e-02 1.831 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.475524e-02 1.831 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.475524e-02 1.831 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.475524e-02 1.831 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.475524e-02 1.831 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.298298e-02 1.887 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.450758e-02 1.838 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 1.377930e-02 1.861 0 0
Ub-specific processing proteases R-HSA-5689880 1.450710e-02 1.838 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.483310e-02 1.829 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.595088e-02 1.797 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.724110e-02 1.763 0 0
Disorders of Nervous System Development R-HSA-9697154 1.724110e-02 1.763 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.724110e-02 1.763 0 0
Pervasive developmental disorders R-HSA-9005895 1.724110e-02 1.763 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.654351e-02 1.781 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.705056e-02 1.768 0 0
Signaling by LTK R-HSA-9842663 1.724110e-02 1.763 0 0
Disorders of Developmental Biology R-HSA-9675151 1.878411e-02 1.726 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.878411e-02 1.726 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.914469e-02 1.718 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.914469e-02 1.718 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.803803e-02 1.744 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.891250e-02 1.723 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.891250e-02 1.723 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.908831e-02 1.719 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.848254e-02 1.733 0 0
Mitotic Anaphase R-HSA-68882 1.931896e-02 1.714 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.954365e-02 1.709 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.957640e-02 1.708 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.957640e-02 1.708 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.981466e-02 1.703 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.991199e-02 1.701 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.992956e-02 1.701 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.229681e-02 1.652 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.229681e-02 1.652 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.229681e-02 1.652 0 0
Signaling by RAS mutants R-HSA-6802949 2.229681e-02 1.652 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 2.108728e-02 1.676 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.084684e-02 1.681 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.050933e-02 1.688 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.210879e-02 1.655 0 0
mRNA 3'-end processing R-HSA-72187 2.296582e-02 1.639 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.296711e-02 1.639 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 2.311307e-02 1.636 0 0
RNA Polymerase III Transcription R-HSA-74158 2.311307e-02 1.636 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.327377e-02 1.633 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 2.629217e-02 1.580 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 2.597127e-02 1.586 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.667434e-02 1.574 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.588872e-02 1.587 0 0
HATs acetylate histones R-HSA-3214847 2.632129e-02 1.580 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.540103e-02 1.595 0 0
SDK interactions R-HSA-373756 2.697840e-02 1.569 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.697840e-02 1.569 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.697840e-02 1.569 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.844109e-02 1.546 0 0
Notch-HLH transcription pathway R-HSA-350054 2.799137e-02 1.553 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.897782e-02 1.538 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.923082e-02 1.534 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.878635e-02 1.541 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.811418e-02 1.551 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.897782e-02 1.538 0 0
Nef and signal transduction R-HSA-164944 2.846161e-02 1.546 0 0
Separation of Sister Chromatids R-HSA-2467813 2.787364e-02 1.555 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 3.061542e-02 1.514 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.788265e-02 1.555 0 0
Axon guidance R-HSA-422475 2.962979e-02 1.528 0 0
Nervous system development R-HSA-9675108 3.078789e-02 1.512 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 3.125101e-02 1.505 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.253623e-02 1.488 0 0
HDACs deacetylate histones R-HSA-3214815 3.254620e-02 1.487 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 3.288950e-02 1.483 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.333172e-02 1.477 0 0
Resolution of D-Loop Structures R-HSA-5693537 3.349231e-02 1.475 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 3.403578e-02 1.468 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.403578e-02 1.468 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 3.435290e-02 1.464 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 3.435290e-02 1.464 0 0
Regulation of signaling by CBL R-HSA-912631 3.492832e-02 1.457 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 3.492832e-02 1.457 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.939361e-02 1.405 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.939361e-02 1.405 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.644165e-02 1.438 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.934436e-02 1.405 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 3.759060e-02 1.425 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 3.932511e-02 1.405 0 0
Nuclear import of Rev protein R-HSA-180746 3.847679e-02 1.415 0 0
Mitotic Prophase R-HSA-68875 3.816323e-02 1.418 0 0
Protein ubiquitination R-HSA-8852135 3.859404e-02 1.413 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.970977e-02 1.401 0 0
Membrane Trafficking R-HSA-199991 4.014325e-02 1.396 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 4.147673e-02 1.382 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.147673e-02 1.382 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.147673e-02 1.382 0 0
HIV Life Cycle R-HSA-162587 4.151548e-02 1.382 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 4.188085e-02 1.378 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 4.188085e-02 1.378 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 4.188085e-02 1.378 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 4.188085e-02 1.378 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 4.219303e-02 1.375 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 4.219303e-02 1.375 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.324401e-02 1.364 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 4.360636e-02 1.360 0 0
PTEN Regulation R-HSA-6807070 4.433142e-02 1.353 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.489595e-02 1.348 0 0
Formation of annular gap junctions R-HSA-196025 5.240310e-02 1.281 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 4.852536e-02 1.314 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 4.852536e-02 1.314 0 0
Metabolism of non-coding RNA R-HSA-194441 4.943316e-02 1.306 0 0
snRNP Assembly R-HSA-191859 4.943316e-02 1.306 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.741152e-02 1.324 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 5.185444e-02 1.285 0 0
Homology Directed Repair R-HSA-5693538 5.247130e-02 1.280 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 5.245923e-02 1.280 0 0
HIV Infection R-HSA-162906 5.095956e-02 1.293 0 0
Signaling by EGFR in Cancer R-HSA-1643713 5.337006e-02 1.273 0 0
S Phase R-HSA-69242 5.432596e-02 1.265 0 0
Repression of WNT target genes R-HSA-4641265 5.438462e-02 1.265 0 0
Diseases of mitotic cell cycle R-HSA-9675126 5.545554e-02 1.256 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 5.642668e-02 1.249 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.642668e-02 1.249 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 5.657971e-02 1.247 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 5.661650e-02 1.247 0 0
Intracellular signaling by second messengers R-HSA-9006925 5.685638e-02 1.245 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 6.016845e-02 1.221 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 6.670979e-02 1.176 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 6.670979e-02 1.176 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 6.303476e-02 1.200 0 0
Signaling by PDGFR in disease R-HSA-9671555 5.832470e-02 1.234 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 6.299695e-02 1.201 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 6.733329e-02 1.172 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 6.281213e-02 1.202 0 0
Clathrin-mediated endocytosis R-HSA-8856828 6.030019e-02 1.220 0 0
Nuclear RNA decay R-HSA-9930044 6.299695e-02 1.201 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 6.016845e-02 1.221 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 5.832470e-02 1.234 0 0
G2/M Checkpoints R-HSA-69481 6.504560e-02 1.187 0 0
Activation of ATR in response to replication stress R-HSA-176187 6.299695e-02 1.201 0 0
Cell-Cell communication R-HSA-1500931 6.267530e-02 1.203 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 6.670979e-02 1.176 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 6.145898e-02 1.211 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 6.299695e-02 1.201 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 6.733329e-02 1.172 0 0
ISG15 antiviral mechanism R-HSA-1169408 6.690170e-02 1.175 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 5.832470e-02 1.234 0 0
GP1b-IX-V activation signalling R-HSA-430116 6.746833e-02 1.171 0 0
Gap junction degradation R-HSA-190873 6.746833e-02 1.171 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 6.746833e-02 1.171 0 0
ALK mutants bind TKIs R-HSA-9700645 6.746833e-02 1.171 0 0
Unwinding of DNA R-HSA-176974 6.746833e-02 1.171 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 6.785026e-02 1.168 0 0
mTORC1-mediated signalling R-HSA-166208 6.785026e-02 1.168 0 0
Signaling by KIT in disease R-HSA-9669938 6.785026e-02 1.168 0 0
EPHB-mediated forward signaling R-HSA-3928662 7.020654e-02 1.154 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 7.020654e-02 1.154 0 0
HIV elongation arrest and recovery R-HSA-167287 7.027519e-02 1.153 0 0
Pausing and recovery of HIV elongation R-HSA-167290 7.027519e-02 1.153 0 0
Signaling by ALK R-HSA-201556 7.102491e-02 1.149 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 7.115928e-02 1.148 0 0
Semaphorin interactions R-HSA-373755 7.159672e-02 1.145 0 0
Regulation of CDH1 Function R-HSA-9764561 7.383075e-02 1.132 0 0
Polo-like kinase mediated events R-HSA-156711 7.438517e-02 1.129 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 7.438517e-02 1.129 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 7.526445e-02 1.123 0 0
Mitotic G2-G2/M phases R-HSA-453274 7.771298e-02 1.110 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 9.170508e-02 1.038 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 8.210391e-02 1.086 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 8.210391e-02 1.086 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 8.452205e-02 1.073 0 0
2-LTR circle formation R-HSA-164843 8.452205e-02 1.073 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 8.953497e-02 1.048 0 0
DAP12 signaling R-HSA-2424491 9.010642e-02 1.045 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 8.800651e-02 1.055 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 9.132385e-02 1.039 0 0
PIP3 activates AKT signaling R-HSA-1257604 8.424379e-02 1.074 0 0
Signal attenuation R-HSA-74749 8.452205e-02 1.073 0 0
Recycling pathway of L1 R-HSA-437239 9.421307e-02 1.026 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 9.010642e-02 1.045 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 8.331923e-02 1.079 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 8.936636e-02 1.049 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 9.010642e-02 1.045 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 8.715541e-02 1.060 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 8.953497e-02 1.048 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 8.157631e-02 1.088 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 7.914001e-02 1.102 0 0
Signal regulatory protein family interactions R-HSA-391160 8.045754e-02 1.094 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 8.452205e-02 1.073 0 0
Apoptosis R-HSA-109581 8.083285e-02 1.092 0 0
STING mediated induction of host immune responses R-HSA-1834941 8.682103e-02 1.061 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 9.523405e-02 1.021 0 0
DCC mediated attractive signaling R-HSA-418885 9.559287e-02 1.020 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 9.559287e-02 1.020 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 9.568986e-02 1.019 0 0
MAP2K and MAPK activation R-HSA-5674135 9.701811e-02 1.013 0 0
Signaling by FGFR1 in disease R-HSA-5655302 9.701811e-02 1.013 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 9.799756e-02 1.009 0 0
Signaling by MET R-HSA-6806834 9.799756e-02 1.009 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 9.890282e-02 1.005 0 0
RUNX2 regulates bone development R-HSA-8941326 9.941129e-02 1.003 0 0
RET signaling R-HSA-8853659 9.941129e-02 1.003 0 0
TCR signaling R-HSA-202403 1.001055e-01 1.000 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.003232e-01 0.999 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.003232e-01 0.999 0 0
Signal Transduction R-HSA-162582 1.013638e-01 0.994 1 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 1.016811e-01 0.993 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.016811e-01 0.993 0 0
Co-stimulation by CD28 R-HSA-389356 1.031899e-01 0.986 0 0
Signaling by TGFB family members R-HSA-9006936 1.036763e-01 0.984 1 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.069402e-01 0.971 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.073131e-01 0.969 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.100775e-01 0.958 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.102216e-01 0.958 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.186088e-01 0.926 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.186088e-01 0.926 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.186088e-01 0.926 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.186088e-01 0.926 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.186088e-01 0.926 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 1.186088e-01 0.926 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.186088e-01 0.926 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.322753e-01 0.879 0 0
MET interacts with TNS proteins R-HSA-8875513 1.322753e-01 0.879 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 1.342885e-01 0.872 0 0
SOS-mediated signalling R-HSA-112412 1.342885e-01 0.872 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 1.303953e-01 0.885 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.284928e-01 0.891 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.383864e-01 0.859 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.392723e-01 0.856 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.299282e-01 0.886 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.389355e-01 0.857 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.284928e-01 0.891 0 0
Integration of provirus R-HSA-162592 1.241426e-01 0.906 0 0
Myogenesis R-HSA-525793 1.146753e-01 0.941 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.342885e-01 0.872 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 1.241426e-01 0.906 0 0
Signalling to RAS R-HSA-167044 1.148615e-01 0.940 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.330894e-01 0.876 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.332325e-01 0.875 0 0
Cellular Senescence R-HSA-2559583 1.409662e-01 0.851 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.146753e-01 0.941 0 0
Signaling by SCF-KIT R-HSA-1433557 1.170807e-01 0.932 0 0
G2/M Transition R-HSA-69275 1.343124e-01 0.872 0 0
Host Interactions of HIV factors R-HSA-162909 1.137293e-01 0.944 0 0
Cell junction organization R-HSA-446728 1.300787e-01 0.886 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.322753e-01 0.879 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 1.342885e-01 0.872 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.148615e-01 0.940 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.134569e-01 0.945 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 1.241426e-01 0.906 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 1.148615e-01 0.940 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.332325e-01 0.875 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.423913e-01 0.847 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.456916e-01 0.837 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.456916e-01 0.837 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.231556e-01 0.651 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.231556e-01 0.651 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.231556e-01 0.651 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.231556e-01 0.651 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.231556e-01 0.651 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.231556e-01 0.651 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.231556e-01 0.651 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.231556e-01 0.651 0 0
Regulation of gap junction activity R-HSA-191650 1.760023e-01 0.754 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.760023e-01 0.754 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 1.760023e-01 0.754 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 3.153069e-01 0.501 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.153069e-01 0.501 0 0
Defective TPMT causes TPMT deficiency R-HSA-5578995 3.153069e-01 0.501 0 0
Defective SLC17A5 causes Salla disease (SD) and ISSD R-HSA-5619035 3.153069e-01 0.501 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.153069e-01 0.501 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.153069e-01 0.501 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.153069e-01 0.501 0 0
Defective VWF binding to collagen type I R-HSA-9845622 3.153069e-01 0.501 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.153069e-01 0.501 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 2.215674e-01 0.654 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 2.215674e-01 0.654 0 0
Activation of AKT2 R-HSA-165158 2.215674e-01 0.654 0 0
IRS activation R-HSA-74713 2.215674e-01 0.654 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.215674e-01 0.654 0 0
G2 Phase R-HSA-68911 2.215674e-01 0.654 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.215674e-01 0.654 0 0
Type I hemidesmosome assembly R-HSA-446107 1.637393e-01 0.786 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.464139e-01 0.834 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 1.464139e-01 0.834 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.464139e-01 0.834 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.948815e-01 0.710 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 1.948815e-01 0.710 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 2.679201e-01 0.572 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.965317e-01 0.402 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.965317e-01 0.402 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 3.965317e-01 0.402 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 3.965317e-01 0.402 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.965317e-01 0.402 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.965317e-01 0.402 0 0
Defective ABCB6 causes MCOPCB7 R-HSA-5683371 3.965317e-01 0.402 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.965317e-01 0.402 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 2.273158e-01 0.643 0 0
Folding of actin by CCT/TriC R-HSA-390450 2.273158e-01 0.643 0 0
CREB phosphorylation R-HSA-199920 3.142329e-01 0.503 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.142329e-01 0.503 0 0
Erythropoietin activates STAT5 R-HSA-9027283 3.142329e-01 0.503 0 0
Autointegration results in viral DNA circles R-HSA-177539 3.142329e-01 0.503 0 0
GAB1 signalosome R-HSA-180292 1.687033e-01 0.773 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 1.468749e-01 0.833 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 2.606647e-01 0.584 0 0
Erythropoietin activates RAS R-HSA-9027284 2.209407e-01 0.656 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.209407e-01 0.656 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 1.896789e-01 0.722 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 1.896789e-01 0.722 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 1.642425e-01 0.785 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 1.642425e-01 0.785 0 0
Signaling by Erythropoietin R-HSA-9006335 1.584673e-01 0.800 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.584673e-01 0.800 0 0
Deadenylation of mRNA R-HSA-429947 1.824335e-01 0.739 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 2.945783e-01 0.531 0 0
NF-kB is activated and signals survival R-HSA-209560 2.945783e-01 0.531 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.945783e-01 0.531 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 3.598635e-01 0.444 0 0
Regulation of PTEN localization R-HSA-8948747 3.598635e-01 0.444 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 3.598635e-01 0.444 0 0
Recycling of eIF2:GDP R-HSA-72731 3.598635e-01 0.444 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 4.681250e-01 0.330 0 0
PLC-gamma1 signalling R-HSA-167021 4.681250e-01 0.330 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 4.681250e-01 0.330 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.681250e-01 0.330 0 0
Defective ABCD4 causes MAHCJ R-HSA-5683329 4.681250e-01 0.330 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.681250e-01 0.330 0 0
MET activates PTPN11 R-HSA-8865999 4.681250e-01 0.330 0 0
Defective ABCC2 causes DJS R-HSA-5679001 4.681250e-01 0.330 0 0
Invadopodia formation R-HSA-8941237 4.681250e-01 0.330 0 0
Activation of the pre-replicative complex R-HSA-68962 1.745448e-01 0.758 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.751398e-01 0.560 0 0
EGFR downregulation R-HSA-182971 1.912880e-01 0.718 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.210002e-01 0.656 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 3.287385e-01 0.483 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 3.287385e-01 0.483 0 0
Scavenging by Class F Receptors R-HSA-3000484 3.287385e-01 0.483 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.573520e-01 0.589 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.573520e-01 0.589 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 2.573520e-01 0.589 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 2.412230e-01 0.618 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.412230e-01 0.618 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.412230e-01 0.618 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 4.043223e-01 0.393 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 4.043223e-01 0.393 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 4.043223e-01 0.393 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 4.043223e-01 0.393 0 0
MET promotes cell motility R-HSA-8875878 2.131832e-01 0.671 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 2.619660e-01 0.582 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.619660e-01 0.582 0 0
Formation of the Early Elongation Complex R-HSA-113418 2.619660e-01 0.582 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 3.628609e-01 0.440 0 0
CD28 dependent Vav1 pathway R-HSA-389359 3.628609e-01 0.440 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 3.311987e-01 0.480 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.052515e-01 0.515 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.930538e-01 0.714 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.930538e-01 0.714 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.180620e-01 0.661 0 0
Dual incision in TC-NER R-HSA-6782135 2.180620e-01 0.661 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 2.319280e-01 0.635 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 2.471903e-01 0.607 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.471903e-01 0.607 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.046864e-01 0.516 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 3.296878e-01 0.482 0 0
Germ layer formation at gastrulation R-HSA-9754189 3.594928e-01 0.444 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 3.966953e-01 0.402 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 4.472454e-01 0.349 0 0
WNT mediated activation of DVL R-HSA-201688 4.472454e-01 0.349 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 4.472454e-01 0.349 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 5.312285e-01 0.275 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 5.312285e-01 0.275 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 5.312285e-01 0.275 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 5.312285e-01 0.275 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.312285e-01 0.275 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.312285e-01 0.275 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 5.312285e-01 0.275 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 5.312285e-01 0.275 0 0
AURKA Activation by TPX2 R-HSA-8854518 2.310279e-01 0.636 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 3.877542e-01 0.411 0 0
Spry regulation of FGF signaling R-HSA-1295596 4.300250e-01 0.367 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 4.300250e-01 0.367 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 4.300250e-01 0.367 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 2.931185e-01 0.533 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 2.894491e-01 0.538 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 4.158420e-01 0.381 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 4.883716e-01 0.311 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 4.883716e-01 0.311 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 3.308666e-01 0.480 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.461783e-01 0.609 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 4.626656e-01 0.335 0 0
Phosphorylation of the APC/C R-HSA-176412 4.626656e-01 0.335 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 4.626656e-01 0.335 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.289967e-01 0.483 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.657492e-01 0.437 0 0
Post-translational protein phosphorylation R-HSA-8957275 3.068278e-01 0.513 0 0
RAF activation R-HSA-5673000 4.149716e-01 0.382 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 4.149716e-01 0.382 0 0
Dual Incision in GG-NER R-HSA-5696400 4.149716e-01 0.382 0 0
Translation initiation complex formation R-HSA-72649 3.833405e-01 0.416 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 3.745232e-01 0.427 0 0
Centrosome maturation R-HSA-380287 3.586073e-01 0.445 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 3.444580e-01 0.463 0 0
FGFR2 alternative splicing R-HSA-6803529 4.709991e-01 0.327 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 5.275232e-01 0.278 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 5.275232e-01 0.278 0 0
G1/S-Specific Transcription R-HSA-69205 4.589282e-01 0.338 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 4.187854e-01 0.378 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 4.978534e-01 0.303 0 0
Interleukin receptor SHC signaling R-HSA-912526 4.978534e-01 0.303 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.538531e-01 0.343 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 5.252920e-01 0.280 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 5.002051e-01 0.301 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 5.002051e-01 0.301 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 4.473262e-01 0.349 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.864734e-01 0.313 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 5.241036e-01 0.281 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 5.241036e-01 0.281 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.645900e-01 0.248 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.645900e-01 0.248 0 0
Signaling by AMER1 mutants R-HSA-4839748 5.645900e-01 0.248 0 0
Signaling by GSK3beta mutants R-HSA-5339716 5.645900e-01 0.248 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 5.035236e-01 0.298 0 0
Nucleosome assembly R-HSA-774815 5.035236e-01 0.298 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.035236e-01 0.298 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 5.048101e-01 0.297 0 0
Meiotic synapsis R-HSA-1221632 5.048101e-01 0.297 0 0
Cap-dependent Translation Initiation R-HSA-72737 4.750551e-01 0.323 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 5.550520e-01 0.256 0 0
PKA activation R-HSA-163615 5.550520e-01 0.256 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 5.229651e-01 0.282 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 5.438410e-01 0.265 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 5.421149e-01 0.266 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 5.408253e-01 0.267 0 0
Chaperonin-mediated protein folding R-HSA-390466 5.524325e-01 0.258 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.584443e-01 0.253 0 0
Striated Muscle Contraction R-HSA-390522 5.684610e-01 0.245 0 0
MET activates PTK2 signaling R-HSA-8874081 5.745038e-01 0.241 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 5.836666e-01 0.234 0 0
Transcription of the HIV genome R-HSA-167172 2.578556e-01 0.589 0 0
Eukaryotic Translation Initiation R-HSA-72613 4.750551e-01 0.323 0 0
IGF1R signaling cascade R-HSA-2428924 2.053842e-01 0.687 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.405648e-01 0.619 0 0
DNA Double Strand Break Response R-HSA-5693606 1.604457e-01 0.795 0 0
Downstream signal transduction R-HSA-186763 5.002051e-01 0.301 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.641245e-01 0.578 0 0
HIV Transcription Elongation R-HSA-167169 3.830398e-01 0.417 0 0
Chromosome Maintenance R-HSA-73886 5.368879e-01 0.270 0 0
Insulin receptor signalling cascade R-HSA-74751 5.564611e-01 0.255 0 0
Downstream TCR signaling R-HSA-202424 4.810547e-01 0.318 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.059451e-01 0.296 0 0
mRNA Capping R-HSA-72086 2.831476e-01 0.548 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 3.553108e-01 0.449 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 3.553108e-01 0.449 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 4.906712e-01 0.309 0 0
MET activates RAS signaling R-HSA-8851805 3.287385e-01 0.483 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 3.030259e-01 0.519 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.210002e-01 0.656 0 0
IRS-mediated signalling R-HSA-112399 5.757685e-01 0.240 0 0
Generation of second messenger molecules R-HSA-202433 2.467368e-01 0.608 0 0
DNA Damage Bypass R-HSA-73893 5.794072e-01 0.237 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 1.700963e-01 0.769 0 0
TGFBR3 expression R-HSA-9839394 2.013777e-01 0.696 0 0
HSF1-dependent transactivation R-HSA-3371571 3.308666e-01 0.480 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.830398e-01 0.417 0 0
G1/S Transition R-HSA-69206 2.430508e-01 0.614 0 0
DNA strand elongation R-HSA-69190 2.086462e-01 0.681 0 0
Aggrephagy R-HSA-9646399 2.467368e-01 0.608 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 1.745448e-01 0.758 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 4.158420e-01 0.381 0 0
RNA Polymerase I Transcription R-HSA-73864 2.954824e-01 0.529 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 3.553108e-01 0.449 0 0
Pexophagy R-HSA-9664873 4.883716e-01 0.311 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 2.180483e-01 0.661 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 3.789835e-01 0.421 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.209407e-01 0.656 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 2.013777e-01 0.696 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.815500e-01 0.741 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 4.883716e-01 0.311 0 0
PCP/CE pathway R-HSA-4086400 4.036789e-01 0.394 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 5.641587e-01 0.249 0 0
Nephron development R-HSA-9831926 5.550520e-01 0.256 0 0
UCH proteinases R-HSA-5689603 3.735670e-01 0.428 0 0
PI3K/AKT activation R-HSA-198203 2.273158e-01 0.643 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 1.468749e-01 0.833 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 3.598635e-01 0.444 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.627636e-01 0.440 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 4.626656e-01 0.335 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 3.735670e-01 0.428 0 0
Regulation of Apoptosis R-HSA-169911 4.370284e-01 0.359 0 0
Molecules associated with elastic fibres R-HSA-2129379 5.002051e-01 0.301 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 5.234560e-01 0.281 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.231104e-01 0.281 0 0
Chaperone Mediated Autophagy R-HSA-9613829 3.311987e-01 0.480 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.745448e-01 0.758 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.857024e-01 0.544 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.521562e-01 0.818 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 3.287385e-01 0.483 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.896056e-01 0.722 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.851099e-01 0.733 0 0
Rab regulation of trafficking R-HSA-9007101 3.914755e-01 0.407 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.573520e-01 0.589 0 0
ER to Golgi Anterograde Transport R-HSA-199977 5.147080e-01 0.288 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.805048e-01 0.744 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.760023e-01 0.754 0 0
Activation of RAC1 R-HSA-428540 2.945783e-01 0.531 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.751398e-01 0.560 0 0
Trafficking of AMPA receptors R-HSA-399719 1.912880e-01 0.718 0 0
Sodium/Proton exchangers R-HSA-425986 4.043223e-01 0.393 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 3.311987e-01 0.480 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.467368e-01 0.608 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 5.312285e-01 0.275 0 0
Mitochondrial biogenesis R-HSA-1592230 1.630607e-01 0.788 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.857024e-01 0.544 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 5.229377e-01 0.282 0 0
Synthesis of DNA R-HSA-69239 3.378074e-01 0.471 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 2.210002e-01 0.656 0 0
Stabilization of p53 R-HSA-69541 3.627636e-01 0.440 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.851041e-01 0.545 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 3.371729e-01 0.472 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.670379e-01 0.777 0 0
Signaling by FGFR2 R-HSA-5654738 3.231263e-01 0.491 0 0
Long-term potentiation R-HSA-9620244 2.013777e-01 0.696 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.297414e-01 0.639 0 0
Rap1 signalling R-HSA-392517 3.594928e-01 0.444 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 4.524937e-01 0.344 0 0
Degradation of DVL R-HSA-4641258 4.806117e-01 0.318 0 0
Signaling by FGFR4 R-HSA-5654743 2.009099e-01 0.697 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.520388e-01 0.818 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.569432e-01 0.447 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 4.713456e-01 0.327 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 2.831476e-01 0.548 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 3.046864e-01 0.516 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 4.370284e-01 0.359 0 0
rRNA processing R-HSA-72312 1.547549e-01 0.810 0 0
Vesicle-mediated transport R-HSA-5653656 4.605313e-01 0.337 0 0
Signaling by FGFR3 R-HSA-5654741 2.313638e-01 0.636 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 2.215674e-01 0.654 0 0
PTK6 Expression R-HSA-8849473 3.598635e-01 0.444 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.751398e-01 0.560 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.265649e-01 0.645 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.604457e-01 0.795 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.620249e-01 0.790 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 3.966953e-01 0.402 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 4.472454e-01 0.349 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.310279e-01 0.636 0 0
Negative regulation of MET activity R-HSA-6807004 3.877542e-01 0.411 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 2.894491e-01 0.538 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 4.158420e-01 0.381 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 2.278608e-01 0.642 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 4.370284e-01 0.359 0 0
Formation of the posterior neural plate R-HSA-9832991 5.275232e-01 0.278 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.978534e-01 0.303 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 5.252920e-01 0.280 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 5.645900e-01 0.248 0 0
Adipogenesis R-HSA-9843745 4.901385e-01 0.310 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 5.438410e-01 0.265 0 0
G-protein mediated events R-HSA-112040 3.506599e-01 0.455 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 3.928890e-01 0.406 0 0
Mismatch Repair R-HSA-5358508 3.311987e-01 0.480 0 0
Cyclin D associated events in G1 R-HSA-69231 3.366648e-01 0.473 0 0
G1 Phase R-HSA-69236 3.366648e-01 0.473 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 4.828876e-01 0.316 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.831476e-01 0.548 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.225284e-01 0.491 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.380091e-01 0.471 0 0
Oncogene Induced Senescence R-HSA-2559585 4.370284e-01 0.359 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 4.300250e-01 0.367 0 0
Acyl chain remodelling of PS R-HSA-1482801 5.496747e-01 0.260 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 5.496747e-01 0.260 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.457526e-01 0.610 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.457526e-01 0.610 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.457526e-01 0.610 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.457526e-01 0.610 0 0
Signaling by NOTCH R-HSA-157118 5.816144e-01 0.235 0 0
Formation of definitive endoderm R-HSA-9823730 2.115228e-01 0.675 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 3.265014e-01 0.486 0 0
p75NTR signals via NF-kB R-HSA-193639 4.300250e-01 0.367 0 0
Autophagy R-HSA-9612973 4.408517e-01 0.356 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 4.446853e-01 0.352 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 3.181759e-01 0.497 0 0
ESR-mediated signaling R-HSA-8939211 2.875273e-01 0.541 0 0
Signaling by FGFR1 R-HSA-5654736 4.186381e-01 0.378 0 0
Lipophagy R-HSA-9613354 1.948815e-01 0.710 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 2.679201e-01 0.572 0 0
p38MAPK events R-HSA-171007 2.209407e-01 0.656 0 0
Heme signaling R-HSA-9707616 2.746289e-01 0.561 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 4.709991e-01 0.327 0 0
GPER1 signaling R-HSA-9634597 5.609391e-01 0.251 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.763235e-01 0.754 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 4.552796e-01 0.342 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.110543e-01 0.676 0 0
Elastic fibre formation R-HSA-1566948 3.425738e-01 0.465 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.285030e-01 0.641 0 0
Neurexins and neuroligins R-HSA-6794361 2.319280e-01 0.635 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.706447e-01 0.431 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.493398e-01 0.603 0 0
Macroautophagy R-HSA-1632852 2.745821e-01 0.561 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 3.142329e-01 0.503 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.265649e-01 0.645 0 0
Kinesins R-HSA-983189 1.582301e-01 0.801 0 0
tRNA processing in the nucleus R-HSA-6784531 1.810744e-01 0.742 0 0
Selective autophagy R-HSA-9663891 2.501985e-01 0.602 0 0
TBC/RABGAPs R-HSA-8854214 4.639168e-01 0.334 0 0
Circadian clock R-HSA-9909396 5.018859e-01 0.299 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 2.831476e-01 0.548 0 0
PLC beta mediated events R-HSA-112043 2.600549e-01 0.585 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 4.472454e-01 0.349 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.052515e-01 0.515 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.681857e-01 0.774 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.305512e-01 0.366 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.305512e-01 0.366 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 3.143924e-01 0.503 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 2.641245e-01 0.578 0 0
Signaling by FGFR4 in disease R-HSA-5655291 1.950028e-01 0.710 0 0
Gene Silencing by RNA R-HSA-211000 3.378074e-01 0.471 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.711573e-01 0.767 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.265649e-01 0.645 0 0
Ca2+ pathway R-HSA-4086398 4.453112e-01 0.351 0 0
DAP12 interactions R-HSA-2172127 3.366648e-01 0.473 0 0
Cell-cell junction organization R-HSA-421270 1.795916e-01 0.746 0 0
Adherens junctions interactions R-HSA-418990 1.578553e-01 0.802 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.231556e-01 0.651 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.153069e-01 0.501 0 0
Reelin signalling pathway R-HSA-8866376 2.215674e-01 0.654 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.948815e-01 0.710 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.965317e-01 0.402 0 0
C6 deamination of adenosine R-HSA-75102 3.965317e-01 0.402 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.965317e-01 0.402 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.965317e-01 0.402 0 0
Bicarbonate transporters R-HSA-425381 2.606647e-01 0.584 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.209407e-01 0.656 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 2.477166e-01 0.606 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.521562e-01 0.818 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.573520e-01 0.589 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.628609e-01 0.440 0 0
Degradation of CDH1 R-HSA-9766229 1.896056e-01 0.722 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.694617e-01 0.771 0 0
Regulation of gene expression in beta cells R-HSA-210745 2.831476e-01 0.548 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 4.472454e-01 0.349 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 5.312285e-01 0.275 0 0
Orc1 removal from chromatin R-HSA-68949 3.482453e-01 0.458 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 4.626656e-01 0.335 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 5.241036e-01 0.281 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 5.152447e-01 0.288 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 5.836666e-01 0.234 0 0
Post NMDA receptor activation events R-HSA-438064 1.637565e-01 0.786 0 0
Signaling by NOTCH1 R-HSA-1980143 2.685708e-01 0.571 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 5.390800e-01 0.268 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.910892e-01 0.536 0 0
Ca-dependent events R-HSA-111996 2.998912e-01 0.523 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.911430e-01 0.408 0 0
ABC-family proteins mediated transport R-HSA-382556 5.373777e-01 0.270 0 0
Signaling by NTRKs R-HSA-166520 2.140023e-01 0.670 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.127006e-01 0.672 0 0
Laminin interactions R-HSA-3000157 5.496747e-01 0.260 0 0
FLT3 Signaling R-HSA-9607240 1.587132e-01 0.799 0 0
Signaling by FGFR in disease R-HSA-1226099 2.425464e-01 0.615 0 0
DAG and IP3 signaling R-HSA-1489509 2.313638e-01 0.636 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.641245e-01 0.578 0 0
Biotin transport and metabolism R-HSA-196780 4.300250e-01 0.367 0 0
Gap junction trafficking and regulation R-HSA-157858 4.305512e-01 0.366 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 4.300250e-01 0.367 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 5.836666e-01 0.234 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 4.428045e-01 0.354 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.669987e-01 0.573 0 0
Uptake and function of anthrax toxins R-HSA-5210891 3.030259e-01 0.519 0 0
L1CAM interactions R-HSA-373760 2.168751e-01 0.664 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 5.252920e-01 0.280 0 0
FLT3 signaling in disease R-HSA-9682385 1.815500e-01 0.741 0 0
Signaling by ERBB4 R-HSA-1236394 1.620249e-01 0.790 0 0
Regulation of TNFR1 signaling R-HSA-5357905 5.229651e-01 0.282 0 0
Signalling to ERKs R-HSA-187687 2.831087e-01 0.548 0 0
Calmodulin induced events R-HSA-111933 3.026866e-01 0.519 0 0
Assembly of the pre-replicative complex R-HSA-68867 5.376589e-01 0.269 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.948815e-01 0.710 0 0
NRIF signals cell death from the nucleus R-HSA-205043 3.966953e-01 0.402 0 0
ERK/MAPK targets R-HSA-198753 4.158420e-01 0.381 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 4.944632e-01 0.306 0 0
MHC class II antigen presentation R-HSA-2132295 4.645952e-01 0.333 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.175554e-01 0.662 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.641329e-01 0.785 0 0
MAPK family signaling cascades R-HSA-5683057 4.807021e-01 0.318 0 0
CaM pathway R-HSA-111997 3.026866e-01 0.519 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.781487e-01 0.556 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 5.610365e-01 0.251 0 0
Netrin-1 signaling R-HSA-373752 4.838274e-01 0.315 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 4.499681e-01 0.347 0 0
RMTs methylate histone arginines R-HSA-3214858 2.159256e-01 0.666 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 1.948815e-01 0.710 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.948815e-01 0.710 0 0
GPVI-mediated activation cascade R-HSA-114604 1.815500e-01 0.741 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.511371e-01 0.821 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 2.131832e-01 0.671 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 5.312285e-01 0.275 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 4.626656e-01 0.335 0 0
G-protein beta:gamma signalling R-HSA-397795 5.462248e-01 0.263 0 0
Signaling by TGFBR3 R-HSA-9839373 2.471903e-01 0.607 0 0
Regulation of beta-cell development R-HSA-186712 3.415274e-01 0.467 0 0
Inositol phosphate metabolism R-HSA-1483249 1.635876e-01 0.786 0 0
Smooth Muscle Contraction R-HSA-445355 3.657492e-01 0.437 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 5.745038e-01 0.241 0 0
Signaling by ROBO receptors R-HSA-376176 2.488796e-01 0.604 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 5.252920e-01 0.280 0 0
Death Receptor Signaling R-HSA-73887 2.665004e-01 0.574 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.273158e-01 0.643 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 5.438410e-01 0.265 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 5.438410e-01 0.265 0 0
Interleukin-15 signaling R-HSA-8983432 3.287385e-01 0.483 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.153069e-01 0.501 0 0
Inhibition of membrane repair R-HSA-9635644 3.153069e-01 0.501 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 3.142329e-01 0.503 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 2.606647e-01 0.584 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.681250e-01 0.330 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.043223e-01 0.393 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 2.265649e-01 0.645 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.265649e-01 0.645 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.457526e-01 0.610 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 5.645900e-01 0.248 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.645900e-01 0.248 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 5.684610e-01 0.245 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 3.943815e-01 0.404 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 2.412230e-01 0.618 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 2.412230e-01 0.618 0 0
Potential therapeutics for SARS R-HSA-9679191 2.309354e-01 0.637 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.700963e-01 0.769 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.209407e-01 0.656 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 5.234560e-01 0.281 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 3.289967e-01 0.483 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.811015e-01 0.551 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.831087e-01 0.548 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.472454e-01 0.349 0 0
NRAGE signals death through JNK R-HSA-193648 4.186381e-01 0.378 0 0
Tie2 Signaling R-HSA-210993 5.550520e-01 0.256 0 0
Interleukin-2 family signaling R-HSA-451927 5.438410e-01 0.265 0 0
Interleukin-7 signaling R-HSA-1266695 2.013777e-01 0.696 0 0
Syndecan interactions R-HSA-3000170 3.052515e-01 0.515 0 0
Diseases of DNA repair R-HSA-9675135 2.471903e-01 0.607 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 2.811015e-01 0.551 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.818583e-01 0.550 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 3.965317e-01 0.402 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 3.598635e-01 0.444 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.587132e-01 0.799 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 5.550520e-01 0.256 0 0
SARS-CoV-1-host interactions R-HSA-9692914 5.241494e-01 0.281 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.035261e-01 0.691 0 0
Programmed Cell Death R-HSA-5357801 2.726748e-01 0.564 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 4.864734e-01 0.313 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 5.241036e-01 0.281 0 0
Neurodegenerative Diseases R-HSA-8863678 5.241036e-01 0.281 0 0
NOD1/2 Signaling Pathway R-HSA-168638 4.149716e-01 0.382 0 0
The NLRP3 inflammasome R-HSA-844456 5.836666e-01 0.234 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.362730e-01 0.360 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 5.370026e-01 0.270 0 0
Interleukin-2 signaling R-HSA-9020558 2.606647e-01 0.584 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 3.965317e-01 0.402 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 3.598635e-01 0.444 0 0
NGF processing R-HSA-167060 4.681250e-01 0.330 0 0
Expression and Processing of Neurotrophins R-HSA-9036866 4.681250e-01 0.330 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 4.043223e-01 0.393 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 3.628609e-01 0.440 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 4.472454e-01 0.349 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.472454e-01 0.349 0 0
Interleukin-1 processing R-HSA-448706 4.472454e-01 0.349 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 5.020244e-01 0.299 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 3.311987e-01 0.480 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 4.626656e-01 0.335 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 5.564611e-01 0.255 0 0
Josephin domain DUBs R-HSA-5689877 4.883716e-01 0.311 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 4.626656e-01 0.335 0 0
Specification of primordial germ cells R-HSA-9827857 5.252920e-01 0.280 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 4.411217e-01 0.355 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 5.584443e-01 0.253 0 0
Signaling by Leptin R-HSA-2586552 4.883716e-01 0.311 0 0
Synthesis and processing of ENV and VPU R-HSA-171286 3.965317e-01 0.402 0 0
Interleukin-37 signaling R-HSA-9008059 3.046864e-01 0.516 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 5.840328e-01 0.234 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 5.840328e-01 0.234 0 0
HIV Transcription Initiation R-HSA-167161 5.840328e-01 0.234 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 5.840328e-01 0.234 0 0
Intra-Golgi traffic R-HSA-6811438 5.840328e-01 0.234 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 5.840328e-01 0.234 0 0
NrCAM interactions R-HSA-447038 5.868483e-01 0.231 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 5.868483e-01 0.231 0 0
NTRK2 activates RAC1 R-HSA-9032759 5.868483e-01 0.231 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 5.868483e-01 0.231 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.868483e-01 0.231 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.868483e-01 0.231 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.868483e-01 0.231 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.868483e-01 0.231 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.868483e-01 0.231 0 0
Inositol transporters R-HSA-429593 5.868483e-01 0.231 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 5.868483e-01 0.231 0 0
RAF/MAP kinase cascade R-HSA-5673001 5.869492e-01 0.231 0 0
Cellular responses to stimuli R-HSA-8953897 5.870972e-01 0.231 0 0
Opioid Signalling R-HSA-111885 5.899211e-01 0.229 0 0
Signaling by NOTCH2 R-HSA-1980145 5.901214e-01 0.229 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 5.901214e-01 0.229 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 5.901214e-01 0.229 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.921088e-01 0.228 0 0
Cytoprotection by HMOX1 R-HSA-9707564 5.974739e-01 0.224 0 0
Regulation of RAS by GAPs R-HSA-5658442 5.974916e-01 0.224 0 0
PI3K Cascade R-HSA-109704 5.974916e-01 0.224 0 0
Signaling by FGFR2 in disease R-HSA-5655253 5.974916e-01 0.224 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 5.985395e-01 0.223 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 5.985395e-01 0.223 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.985395e-01 0.223 0 0
Signaling by FGFR3 in disease R-HSA-5655332 5.985395e-01 0.223 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 5.985395e-01 0.223 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 5.995154e-01 0.222 0 0
Leading Strand Synthesis R-HSA-69109 5.995154e-01 0.222 0 0
Polymerase switching R-HSA-69091 5.995154e-01 0.222 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 5.995154e-01 0.222 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 5.995154e-01 0.222 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 5.995154e-01 0.222 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 5.995154e-01 0.222 0 0
VLDLR internalisation and degradation R-HSA-8866427 5.995154e-01 0.222 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.995154e-01 0.222 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 5.995154e-01 0.222 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 5.995154e-01 0.222 0 0
Nephrin family interactions R-HSA-373753 6.110801e-01 0.214 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 6.152199e-01 0.211 0 0
Interleukin-12 signaling R-HSA-9020591 6.156184e-01 0.211 0 0
Signaling by FGFR R-HSA-190236 6.182588e-01 0.209 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 6.182588e-01 0.209 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 6.182588e-01 0.209 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 6.182588e-01 0.209 0 0
IRE1alpha activates chaperones R-HSA-381070 6.216971e-01 0.206 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 6.223276e-01 0.206 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 6.223276e-01 0.206 0 0
Cellular responses to stress R-HSA-2262752 6.254743e-01 0.204 0 0
Meiosis R-HSA-1500620 6.256210e-01 0.204 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 6.257457e-01 0.204 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 6.315744e-01 0.200 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 6.316668e-01 0.200 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 6.322857e-01 0.199 0 0
Formation of axial mesoderm R-HSA-9796292 6.322857e-01 0.199 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 6.322857e-01 0.199 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 6.322857e-01 0.199 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 6.324157e-01 0.199 0 0
Cilium Assembly R-HSA-5617833 6.337171e-01 0.198 0 0
Protein folding R-HSA-391251 6.349021e-01 0.197 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.358717e-01 0.197 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 6.358717e-01 0.197 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 6.358717e-01 0.197 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 6.358717e-01 0.197 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 6.358717e-01 0.197 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 6.358717e-01 0.197 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.358717e-01 0.197 0 0
PDE3B signalling R-HSA-165160 6.358717e-01 0.197 0 0
PKB-mediated events R-HSA-109703 6.358717e-01 0.197 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.358717e-01 0.197 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 6.358717e-01 0.197 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.358717e-01 0.197 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 6.358717e-01 0.197 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 6.358717e-01 0.197 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 6.358717e-01 0.197 0 0
Lagging Strand Synthesis R-HSA-69186 6.372552e-01 0.196 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 6.372552e-01 0.196 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 6.372552e-01 0.196 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 6.372552e-01 0.196 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.372552e-01 0.196 0 0
Basigin interactions R-HSA-210991 6.372552e-01 0.196 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.393115e-01 0.194 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 6.393115e-01 0.194 0 0
Gap junction trafficking R-HSA-190828 6.406977e-01 0.193 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 6.408893e-01 0.193 0 0
MAP kinase activation R-HSA-450294 6.416757e-01 0.193 0 0
DARPP-32 events R-HSA-180024 6.440767e-01 0.191 0 0
Platelet calcium homeostasis R-HSA-418360 6.440767e-01 0.191 0 0
Integrin cell surface interactions R-HSA-216083 6.443779e-01 0.191 0 0
ABC transporter disorders R-HSA-5619084 6.443779e-01 0.191 0 0
G alpha (12/13) signalling events R-HSA-416482 6.443779e-01 0.191 0 0
TCF dependent signaling in response to WNT R-HSA-201681 6.448198e-01 0.191 0 0
Regulation of PTEN stability and activity R-HSA-8948751 6.492158e-01 0.188 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 6.492158e-01 0.188 0 0
Co-inhibition by PD-1 R-HSA-389948 6.499763e-01 0.187 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 6.502682e-01 0.187 0 0
Degradation of AXIN R-HSA-4641257 6.513125e-01 0.186 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 6.517286e-01 0.186 0 0
XBP1(S) activates chaperone genes R-HSA-381038 6.527320e-01 0.185 0 0
Signaling by WNT R-HSA-195721 6.557111e-01 0.183 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 6.558985e-01 0.183 0 0
Signaling by PDGF R-HSA-186797 6.572150e-01 0.182 0 0
NCAM signaling for neurite out-growth R-HSA-375165 6.572150e-01 0.182 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 6.572150e-01 0.182 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 6.585227e-01 0.181 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 6.585227e-01 0.181 0 0
Fanconi Anemia Pathway R-HSA-6783310 6.585227e-01 0.181 0 0
Somitogenesis R-HSA-9824272 6.585227e-01 0.181 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 6.605784e-01 0.180 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 6.621709e-01 0.179 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 6.621709e-01 0.179 0 0
CRMPs in Sema3A signaling R-HSA-399956 6.629207e-01 0.179 0 0
Retrograde neurotrophin signalling R-HSA-177504 6.629207e-01 0.179 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 6.629207e-01 0.179 0 0
Zinc transporters R-HSA-435354 6.629207e-01 0.179 0 0
DNA Replication Pre-Initiation R-HSA-69002 6.634816e-01 0.178 0 0
DNA Replication R-HSA-69306 6.639747e-01 0.178 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 6.655253e-01 0.177 0 0
Activation of BH3-only proteins R-HSA-114452 6.655253e-01 0.177 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 6.719196e-01 0.173 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 6.730328e-01 0.172 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 6.737270e-01 0.172 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 6.750147e-01 0.171 0 0
MyD88-independent TLR4 cascade R-HSA-166166 6.750147e-01 0.171 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 6.757873e-01 0.170 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 6.760460e-01 0.170 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 6.789020e-01 0.168 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 6.790807e-01 0.168 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.790807e-01 0.168 0 0
STAT5 Activation R-HSA-9645135 6.790807e-01 0.168 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 6.790807e-01 0.168 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 6.790807e-01 0.168 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 6.790807e-01 0.168 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 6.790807e-01 0.168 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 6.790807e-01 0.168 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 6.790807e-01 0.168 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 6.790807e-01 0.168 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.790807e-01 0.168 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.790807e-01 0.168 0 0
Abacavir transmembrane transport R-HSA-2161517 6.790807e-01 0.168 0 0
Signaling by LTK in cancer R-HSA-9842640 6.790807e-01 0.168 0 0
HDL clearance R-HSA-8964011 6.790807e-01 0.168 0 0
Leukotriene receptors R-HSA-391906 6.790807e-01 0.168 0 0
Neurofascin interactions R-HSA-447043 6.790807e-01 0.168 0 0
Unfolded Protein Response (UPR) R-HSA-381119 6.803223e-01 0.167 0 0
Signaling by NOTCH3 R-HSA-9012852 6.814156e-01 0.167 0 0
Influenza Infection R-HSA-168255 6.835920e-01 0.165 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 6.852215e-01 0.164 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 6.858200e-01 0.164 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 6.858200e-01 0.164 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 6.860724e-01 0.164 0 0
Ion transport by P-type ATPases R-HSA-936837 6.870732e-01 0.163 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 6.887178e-01 0.162 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 6.914366e-01 0.160 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 6.914656e-01 0.160 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.914656e-01 0.160 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 6.914656e-01 0.160 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.914656e-01 0.160 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 6.914656e-01 0.160 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 6.914656e-01 0.160 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 6.914656e-01 0.160 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 6.914656e-01 0.160 0 0
Formation of the anterior neural plate R-HSA-9823739 6.914656e-01 0.160 0 0
DNA Damage Reversal R-HSA-73942 6.914656e-01 0.160 0 0
TNF signaling R-HSA-75893 6.967927e-01 0.157 0 0
Ion homeostasis R-HSA-5578775 6.967927e-01 0.157 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 7.031276e-01 0.153 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 7.031276e-01 0.153 0 0
Signaling by WNT in cancer R-HSA-4791275 7.057117e-01 0.151 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 7.057117e-01 0.151 0 0
Signaling by NOTCH4 R-HSA-9013694 7.060687e-01 0.151 0 0
Attenuation phase R-HSA-3371568 7.063630e-01 0.151 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.063630e-01 0.151 0 0
Diseases of Immune System R-HSA-5260271 7.063630e-01 0.151 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 7.082074e-01 0.150 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 7.082074e-01 0.150 0 0
Carnitine shuttle R-HSA-200425 7.082074e-01 0.150 0 0
Growth hormone receptor signaling R-HSA-982772 7.082074e-01 0.150 0 0
Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-159782 7.171645e-01 0.144 0 0
IFNG signaling activates MAPKs R-HSA-9732724 7.171645e-01 0.144 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 7.171645e-01 0.144 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 7.171645e-01 0.144 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 7.171645e-01 0.144 0 0
Disinhibition of SNARE formation R-HSA-114516 7.171645e-01 0.144 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 7.171645e-01 0.144 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 7.171645e-01 0.144 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.171645e-01 0.144 0 0
Mitochondrial ABC transporters R-HSA-1369007 7.171645e-01 0.144 0 0
Opsins R-HSA-419771 7.171645e-01 0.144 0 0
VLDL clearance R-HSA-8964046 7.171645e-01 0.144 0 0
Ca2+ activated K+ channels R-HSA-1296052 7.171645e-01 0.144 0 0
Netrin mediated repulsion signals R-HSA-418886 7.171645e-01 0.144 0 0
CHL1 interactions R-HSA-447041 7.171645e-01 0.144 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 7.171645e-01 0.144 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 7.171645e-01 0.144 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 7.171645e-01 0.144 0 0
Killing mechanisms R-HSA-9664420 7.179850e-01 0.144 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 7.179850e-01 0.144 0 0
Negative regulation of FLT3 R-HSA-9706369 7.179850e-01 0.144 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 7.179850e-01 0.144 0 0
Atorvastatin ADME R-HSA-9754706 7.179850e-01 0.144 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 7.190850e-01 0.143 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 7.190850e-01 0.143 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 7.191074e-01 0.143 0 0
Platelet activation, signaling and aggregation R-HSA-76002 7.197345e-01 0.143 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 7.230726e-01 0.141 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 7.232962e-01 0.141 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 7.260641e-01 0.139 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 7.293480e-01 0.137 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 7.293480e-01 0.137 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 7.293480e-01 0.137 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 7.329899e-01 0.135 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.335957e-01 0.135 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.335957e-01 0.135 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 7.379025e-01 0.132 0 0
Eukaryotic Translation Elongation R-HSA-156842 7.384556e-01 0.132 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.393085e-01 0.131 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 7.395172e-01 0.131 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 7.395172e-01 0.131 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.395172e-01 0.131 0 0
Degradation of CRY and PER proteins R-HSA-9932298 7.395172e-01 0.131 0 0
Extension of Telomeres R-HSA-180786 7.399503e-01 0.131 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 7.416853e-01 0.130 0 0
Glycolysis R-HSA-70171 7.419930e-01 0.130 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 7.422721e-01 0.129 0 0
Vpu mediated degradation of CD4 R-HSA-180534 7.422721e-01 0.129 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 7.425576e-01 0.129 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 7.425576e-01 0.129 0 0
Fibronectin matrix formation R-HSA-1566977 7.425576e-01 0.129 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 7.425576e-01 0.129 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 7.425576e-01 0.129 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 7.425576e-01 0.129 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 7.439626e-01 0.128 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.455755e-01 0.128 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.492653e-01 0.125 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 7.492653e-01 0.125 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 7.492653e-01 0.125 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 7.494647e-01 0.125 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.507308e-01 0.125 0 0
phospho-PLA2 pathway R-HSA-111995 7.507308e-01 0.125 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 7.507308e-01 0.125 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.507308e-01 0.125 0 0
MET receptor recycling R-HSA-8875656 7.507308e-01 0.125 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.507308e-01 0.125 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 7.507308e-01 0.125 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 7.507308e-01 0.125 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.507308e-01 0.125 0 0
Co-stimulation by ICOS R-HSA-9927354 7.507308e-01 0.125 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.507308e-01 0.125 0 0
RSK activation R-HSA-444257 7.507308e-01 0.125 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 7.507308e-01 0.125 0 0
Adrenoceptors R-HSA-390696 7.507308e-01 0.125 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.507308e-01 0.125 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 7.507308e-01 0.125 0 0
Ribosome-associated quality control R-HSA-9948299 7.510930e-01 0.124 0 0
Hedgehog ligand biogenesis R-HSA-5358346 7.534086e-01 0.123 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.556079e-01 0.122 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 7.592096e-01 0.120 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 7.592096e-01 0.120 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 7.592096e-01 0.120 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 7.652719e-01 0.116 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 7.652719e-01 0.116 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 7.652719e-01 0.116 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.652719e-01 0.116 0 0
Formation of paraxial mesoderm R-HSA-9793380 7.662193e-01 0.116 0 0
Interleukin-17 signaling R-HSA-448424 7.663766e-01 0.116 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 7.671753e-01 0.115 0 0
Sensory processing of sound R-HSA-9659379 7.672877e-01 0.115 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 7.679895e-01 0.115 0 0
Metalloprotease DUBs R-HSA-5689901 7.679895e-01 0.115 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.679895e-01 0.115 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 7.684287e-01 0.114 0 0
Leishmania phagocytosis R-HSA-9664417 7.684287e-01 0.114 0 0
Parasite infection R-HSA-9664407 7.684287e-01 0.114 0 0
Interleukin-12 family signaling R-HSA-447115 7.687229e-01 0.114 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 7.716258e-01 0.113 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.720041e-01 0.112 0 0
PERK regulates gene expression R-HSA-381042 7.752706e-01 0.111 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 7.752706e-01 0.111 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 7.752706e-01 0.111 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 7.780676e-01 0.109 0 0
Regulation of mitotic cell cycle R-HSA-453276 7.780676e-01 0.109 0 0
PKR-mediated signaling R-HSA-9833482 7.783679e-01 0.109 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 7.786059e-01 0.109 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 7.786059e-01 0.109 0 0
Gastrulation R-HSA-9758941 7.796971e-01 0.108 0 0
Interferon Signaling R-HSA-913531 7.799551e-01 0.108 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 7.803153e-01 0.108 0 0
ARMS-mediated activation R-HSA-170984 7.803153e-01 0.108 0 0
Calcineurin activates NFAT R-HSA-2025928 7.803153e-01 0.108 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.803153e-01 0.108 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.803153e-01 0.108 0 0
mRNA Editing R-HSA-75072 7.803153e-01 0.108 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 7.803153e-01 0.108 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.803153e-01 0.108 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.803153e-01 0.108 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 7.803153e-01 0.108 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.803153e-01 0.108 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.803153e-01 0.108 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.803153e-01 0.108 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 7.810459e-01 0.107 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 7.839569e-01 0.106 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 7.855566e-01 0.105 0 0
Signaling by Interleukins R-HSA-449147 7.856552e-01 0.105 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 7.862228e-01 0.104 0 0
PKA activation in glucagon signalling R-HSA-164378 7.862228e-01 0.104 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 7.862228e-01 0.104 0 0
Presynaptic function of Kainate receptors R-HSA-500657 7.862228e-01 0.104 0 0
Transport of connexons to the plasma membrane R-HSA-190872 7.862228e-01 0.104 0 0
Platelet sensitization by LDL R-HSA-432142 7.862228e-01 0.104 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 7.904738e-01 0.102 0 0
HSF1 activation R-HSA-3371511 7.904738e-01 0.102 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 7.904738e-01 0.102 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 7.930412e-01 0.101 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.930412e-01 0.101 0 0
Telomere Extension By Telomerase R-HSA-171319 8.020067e-01 0.096 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 8.020067e-01 0.096 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.020067e-01 0.096 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 8.020067e-01 0.096 0 0
Inflammasomes R-HSA-622312 8.020067e-01 0.096 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.048410e-01 0.094 0 0
SARS-CoV-2-host interactions R-HSA-9705683 8.049992e-01 0.094 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 8.050284e-01 0.094 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 8.055087e-01 0.094 0 0
Translesion Synthesis by POLH R-HSA-110320 8.055087e-01 0.094 0 0
Specification of the neural plate border R-HSA-9834899 8.055087e-01 0.094 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 8.055087e-01 0.094 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 8.055087e-01 0.094 0 0
Maturation of nucleoprotein R-HSA-9694631 8.055087e-01 0.094 0 0
Integration of energy metabolism R-HSA-163685 8.063417e-01 0.093 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 8.063901e-01 0.093 0 0
Regulation of CDH11 function R-HSA-9762292 8.063901e-01 0.093 0 0
Binding and entry of HIV virion R-HSA-173107 8.063901e-01 0.093 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 8.063901e-01 0.093 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 8.063901e-01 0.093 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 8.063901e-01 0.093 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 8.063901e-01 0.093 0 0
Regulation of the apoptosome activity R-HSA-9627069 8.063901e-01 0.093 0 0
Receptor Mediated Mitophagy R-HSA-8934903 8.063901e-01 0.093 0 0
Formation of apoptosome R-HSA-111458 8.063901e-01 0.093 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 8.087982e-01 0.092 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 8.122065e-01 0.090 0 0
Late endosomal microautophagy R-HSA-9615710 8.173832e-01 0.088 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 8.173832e-01 0.088 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 8.173832e-01 0.088 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.173832e-01 0.088 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 8.179597e-01 0.087 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.206282e-01 0.086 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 8.222839e-01 0.085 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 8.232298e-01 0.084 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 8.232298e-01 0.084 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 8.232298e-01 0.084 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 8.232298e-01 0.084 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 8.232298e-01 0.084 0 0
Signaling by NODAL R-HSA-1181150 8.232298e-01 0.084 0 0
Protein hydroxylation R-HSA-9629569 8.232298e-01 0.084 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 8.232298e-01 0.084 0 0
Signal transduction by L1 R-HSA-445144 8.232298e-01 0.084 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 8.293713e-01 0.081 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 8.293713e-01 0.081 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 8.293713e-01 0.081 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 8.293713e-01 0.081 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 8.293713e-01 0.081 0 0
Ionotropic activity of kainate receptors R-HSA-451306 8.293713e-01 0.081 0 0
Signaling by APC mutants R-HSA-4839744 8.293713e-01 0.081 0 0
vRNA Synthesis R-HSA-192814 8.293713e-01 0.081 0 0
vRNP Assembly R-HSA-192905 8.293713e-01 0.081 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 8.293713e-01 0.081 0 0
Synthesis of PI R-HSA-1483226 8.293713e-01 0.081 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 8.293713e-01 0.081 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 8.293713e-01 0.081 0 0
Suppression of apoptosis R-HSA-9635465 8.293713e-01 0.081 0 0
Prostanoid ligand receptors R-HSA-391908 8.293713e-01 0.081 0 0
Transport of RCbl within the body R-HSA-9758890 8.293713e-01 0.081 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.293713e-01 0.081 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.311669e-01 0.080 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.311669e-01 0.080 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 8.311669e-01 0.080 0 0
NGF-stimulated transcription R-HSA-9031628 8.337709e-01 0.079 0 0
Metal ion SLC transporters R-HSA-425410 8.337709e-01 0.079 0 0
Interleukin-1 signaling R-HSA-9020702 8.343309e-01 0.079 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.394857e-01 0.076 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 8.394857e-01 0.076 0 0
Signaling by Nuclear Receptors R-HSA-9006931 8.409184e-01 0.075 0 0
Glucose metabolism R-HSA-70326 8.412002e-01 0.075 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 8.431799e-01 0.074 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.431799e-01 0.074 0 0
Cargo concentration in the ER R-HSA-5694530 8.451002e-01 0.073 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.451002e-01 0.073 0 0
Amino acid transport across the plasma membrane R-HSA-352230 8.478230e-01 0.072 0 0
DS-GAG biosynthesis R-HSA-2022923 8.496259e-01 0.071 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 8.496259e-01 0.071 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 8.496259e-01 0.071 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 8.496259e-01 0.071 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 8.496259e-01 0.071 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 8.496259e-01 0.071 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 8.496259e-01 0.071 0 0
ERKs are inactivated R-HSA-202670 8.496259e-01 0.071 0 0
Signaling by AXIN mutants R-HSA-4839735 8.496259e-01 0.071 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 8.496259e-01 0.071 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.496259e-01 0.071 0 0
Anchoring fibril formation R-HSA-2214320 8.496259e-01 0.071 0 0
Uptake of dietary cobalamins into enterocytes R-HSA-9758881 8.496259e-01 0.071 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 8.496259e-01 0.071 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.543745e-01 0.068 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 8.543745e-01 0.068 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 8.544647e-01 0.068 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.544647e-01 0.068 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.544647e-01 0.068 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 8.551635e-01 0.068 0 0
Formation of a pool of free 40S subunits R-HSA-72689 8.588382e-01 0.066 0 0
Eukaryotic Translation Termination R-HSA-72764 8.588382e-01 0.066 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 8.610948e-01 0.065 0 0
Interleukin-1 family signaling R-HSA-446652 8.610948e-01 0.065 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.650514e-01 0.063 0 0
SARS-CoV Infections R-HSA-9679506 8.655887e-01 0.063 0 0
Maple Syrup Urine Disease R-HSA-9865114 8.674772e-01 0.062 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.674772e-01 0.062 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.674772e-01 0.062 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.674772e-01 0.062 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.674772e-01 0.062 0 0
p75NTR recruits signalling complexes R-HSA-209543 8.674772e-01 0.062 0 0
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-HSA-159854 8.674772e-01 0.062 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.674772e-01 0.062 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.674772e-01 0.062 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.674772e-01 0.062 0 0
OAS antiviral response R-HSA-8983711 8.674772e-01 0.062 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.679916e-01 0.061 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 8.679916e-01 0.061 0 0
LDL clearance R-HSA-8964038 8.679916e-01 0.061 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.688155e-01 0.061 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.690887e-01 0.061 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 8.690887e-01 0.061 0 0
Cardiogenesis R-HSA-9733709 8.690887e-01 0.061 0 0
Cytokine Signaling in Immune system R-HSA-1280215 8.700023e-01 0.060 0 0
Telomere Maintenance R-HSA-157579 8.729989e-01 0.059 0 0
Base Excision Repair R-HSA-73884 8.757772e-01 0.058 0 0
Cellular response to chemical stress R-HSA-9711123 8.766831e-01 0.057 0 0
Reproduction R-HSA-1474165 8.792420e-01 0.056 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.798055e-01 0.056 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 8.802927e-01 0.055 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 8.804291e-01 0.055 0 0
Mitochondrial mRNA modification R-HSA-9937008 8.804291e-01 0.055 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 8.804291e-01 0.055 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 8.825727e-01 0.054 0 0
Signaling by PTK6 R-HSA-8848021 8.826292e-01 0.054 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 8.826292e-01 0.054 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.832102e-01 0.054 0 0
Processing of SMDT1 R-HSA-8949664 8.832102e-01 0.054 0 0
rRNA modification in the mitochondrion R-HSA-6793080 8.832102e-01 0.054 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.832102e-01 0.054 0 0
Maturation of nucleoprotein R-HSA-9683610 8.832102e-01 0.054 0 0
Interleukin-6 signaling R-HSA-1059683 8.832102e-01 0.054 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.832102e-01 0.054 0 0
FOXO-mediated transcription R-HSA-9614085 8.859892e-01 0.053 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 8.877026e-01 0.052 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 8.897344e-01 0.051 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.897344e-01 0.051 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.897344e-01 0.051 0 0
Mitophagy R-HSA-5205647 8.897344e-01 0.051 0 0
Signal amplification R-HSA-392518 8.897344e-01 0.051 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 8.905154e-01 0.050 0 0
Hedgehog 'off' state R-HSA-5610787 8.920643e-01 0.050 0 0
Cellular response to starvation R-HSA-9711097 8.928174e-01 0.049 0 0
Proteasome assembly R-HSA-9907900 8.929275e-01 0.049 0 0
Surfactant metabolism R-HSA-5683826 8.929275e-01 0.049 0 0
Signaling by Insulin receptor R-HSA-74752 8.952470e-01 0.048 0 0
Removal of the Flap Intermediate R-HSA-69166 8.970763e-01 0.047 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 8.970763e-01 0.047 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 8.970763e-01 0.047 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.970763e-01 0.047 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 8.970763e-01 0.047 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 8.970763e-01 0.047 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.970763e-01 0.047 0 0
Hydrolysis of LPC R-HSA-1483115 8.970763e-01 0.047 0 0
cGMP effects R-HSA-418457 8.970763e-01 0.047 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.970763e-01 0.047 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.970763e-01 0.047 0 0
Interferon gamma signaling R-HSA-877300 8.974906e-01 0.047 0 0
Adaptive Immune System R-HSA-1280218 8.989133e-01 0.046 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 8.989221e-01 0.046 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.021132e-01 0.045 0 0
Tight junction interactions R-HSA-420029 9.021132e-01 0.045 0 0
Hyaluronan degradation R-HSA-2160916 9.021132e-01 0.045 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 9.053025e-01 0.043 0 0
PRC2 methylates histones and DNA R-HSA-212300 9.074138e-01 0.042 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.074138e-01 0.042 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 9.085802e-01 0.042 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 9.092967e-01 0.041 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.092967e-01 0.041 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 9.092967e-01 0.041 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 9.092967e-01 0.041 0 0
Translesion synthesis by REV1 R-HSA-110312 9.092967e-01 0.041 0 0
Telomere C-strand synthesis initiation R-HSA-174430 9.092967e-01 0.041 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 9.092967e-01 0.041 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 9.092967e-01 0.041 0 0
Protein methylation R-HSA-8876725 9.092967e-01 0.041 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.104613e-01 0.041 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.108986e-01 0.041 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.108986e-01 0.041 0 0
Sphingolipid catabolism R-HSA-9845614 9.115230e-01 0.040 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.115230e-01 0.040 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.144897e-01 0.039 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.152537e-01 0.038 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 9.185531e-01 0.037 0 0
Activation of HOX genes during differentiation R-HSA-5619507 9.185531e-01 0.037 0 0
Toll-like Receptor Cascades R-HSA-168898 9.199421e-01 0.036 0 0
Translesion synthesis by POLI R-HSA-5656121 9.200669e-01 0.036 0 0
Prolonged ERK activation events R-HSA-169893 9.200669e-01 0.036 0 0
Activation of the phototransduction cascade R-HSA-2485179 9.200669e-01 0.036 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 9.200669e-01 0.036 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 9.200669e-01 0.036 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 9.200669e-01 0.036 0 0
Cristae formation R-HSA-8949613 9.200790e-01 0.036 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.200790e-01 0.036 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 9.200790e-01 0.036 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.200790e-01 0.036 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.200790e-01 0.036 0 0
Peptide chain elongation R-HSA-156902 9.213356e-01 0.036 0 0
Intraflagellar transport R-HSA-5620924 9.221653e-01 0.035 0 0
Gluconeogenesis R-HSA-70263 9.221653e-01 0.035 0 0
Developmental Biology R-HSA-1266738 9.234111e-01 0.035 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.242095e-01 0.034 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.261538e-01 0.033 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.278383e-01 0.033 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.278513e-01 0.033 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.278513e-01 0.033 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.282199e-01 0.032 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.291452e-01 0.032 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 9.295587e-01 0.032 0 0
Translesion synthesis by POLK R-HSA-5655862 9.295587e-01 0.032 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 9.295587e-01 0.032 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.295587e-01 0.032 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.295587e-01 0.032 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 9.295587e-01 0.032 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 9.295587e-01 0.032 0 0
Synthesis of PG R-HSA-1483148 9.295587e-01 0.032 0 0
Hedgehog 'on' state R-HSA-5632684 9.323815e-01 0.030 0 0
DNA methylation R-HSA-5334118 9.349053e-01 0.029 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.349053e-01 0.029 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.349053e-01 0.029 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.352530e-01 0.029 0 0
HCMV Early Events R-HSA-9609690 9.359584e-01 0.029 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.379239e-01 0.028 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.379239e-01 0.028 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.379239e-01 0.028 0 0
Glycogen storage diseases R-HSA-3229121 9.379239e-01 0.028 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 9.379239e-01 0.028 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.379239e-01 0.028 0 0
Meiotic recombination R-HSA-912446 9.391569e-01 0.027 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.391569e-01 0.027 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.396877e-01 0.027 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.413020e-01 0.026 0 0
tRNA processing R-HSA-72306 9.416892e-01 0.026 0 0
Neutrophil degranulation R-HSA-6798695 9.430118e-01 0.025 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.440227e-01 0.025 0 0
Platelet degranulation R-HSA-114608 9.440793e-01 0.025 0 0
Leishmania infection R-HSA-9658195 9.451518e-01 0.024 0 0
Parasitic Infection Pathways R-HSA-9824443 9.451518e-01 0.024 0 0
Synaptic adhesion-like molecules R-HSA-8849932 9.452961e-01 0.024 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.452961e-01 0.024 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 9.452961e-01 0.024 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.452961e-01 0.024 0 0
Apoptotic factor-mediated response R-HSA-111471 9.452961e-01 0.024 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.452961e-01 0.024 0 0
Developmental Cell Lineages R-HSA-9734767 9.455594e-01 0.024 0 0
Negative regulation of MAPK pathway R-HSA-5675221 9.460939e-01 0.024 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.470979e-01 0.024 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.485303e-01 0.023 0 0
Crosslinking of collagen fibrils R-HSA-2243919 9.517932e-01 0.021 0 0
Pyrimidine biosynthesis R-HSA-500753 9.517932e-01 0.021 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.517932e-01 0.021 0 0
E2F mediated regulation of DNA replication R-HSA-113510 9.517932e-01 0.021 0 0
Diseases of hemostasis R-HSA-9671793 9.517932e-01 0.021 0 0
Other interleukin signaling R-HSA-449836 9.517932e-01 0.021 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.517932e-01 0.021 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.517932e-01 0.021 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.517932e-01 0.021 0 0
Cellular response to hypoxia R-HSA-1234174 9.522610e-01 0.021 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.525390e-01 0.021 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.532784e-01 0.021 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.549868e-01 0.020 0 0
Muscle contraction R-HSA-397014 9.551231e-01 0.020 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.558899e-01 0.020 0 0
SLC transporter disorders R-HSA-5619102 9.558930e-01 0.020 0 0
Regulation of necroptotic cell death R-HSA-5675482 9.570934e-01 0.019 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.575189e-01 0.019 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.575189e-01 0.019 0 0
Glycogen synthesis R-HSA-3322077 9.575189e-01 0.019 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.575189e-01 0.019 0 0
Creatine metabolism R-HSA-71288 9.575189e-01 0.019 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.575189e-01 0.019 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.591888e-01 0.018 0 0
Kidney development R-HSA-9830369 9.592651e-01 0.018 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.607534e-01 0.017 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.613860e-01 0.017 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.613860e-01 0.017 0 0
Heme degradation R-HSA-189483 9.613860e-01 0.017 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 9.625649e-01 0.017 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.625649e-01 0.017 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.625649e-01 0.017 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.625649e-01 0.017 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.628658e-01 0.016 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.628658e-01 0.016 0 0
ER-Phagosome pathway R-HSA-1236974 9.632383e-01 0.016 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 9.652646e-01 0.015 0 0
Hyaluronan metabolism R-HSA-2142845 9.652646e-01 0.015 0 0
Gap junction assembly R-HSA-190861 9.652646e-01 0.015 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.652646e-01 0.015 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 9.658518e-01 0.015 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.658518e-01 0.015 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.662149e-01 0.015 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.662149e-01 0.015 0 0
CS-GAG biosynthesis R-HSA-2022870 9.670118e-01 0.015 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.670118e-01 0.015 0 0
Attachment and Entry R-HSA-9694614 9.670118e-01 0.015 0 0
Serine metabolism R-HSA-977347 9.670118e-01 0.015 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.670118e-01 0.015 0 0
Assembly Of The HIV Virion R-HSA-175474 9.670118e-01 0.015 0 0
COPII-mediated vesicle transport R-HSA-204005 9.680197e-01 0.014 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.687668e-01 0.014 0 0
Peroxisomal protein import R-HSA-9033241 9.692627e-01 0.014 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 9.701720e-01 0.013 0 0
ECM proteoglycans R-HSA-3000178 9.705278e-01 0.013 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.709306e-01 0.013 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.709306e-01 0.013 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.709306e-01 0.013 0 0
Cellular hexose transport R-HSA-189200 9.709306e-01 0.013 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.709306e-01 0.013 0 0
Selenocysteine synthesis R-HSA-2408557 9.711332e-01 0.013 0 0
Metabolism of polyamines R-HSA-351202 9.718451e-01 0.012 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.719275e-01 0.012 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.723950e-01 0.012 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 9.728525e-01 0.012 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.728525e-01 0.012 0 0
PI Metabolism R-HSA-1483255 9.731008e-01 0.012 0 0
Signaling by Hedgehog R-HSA-5358351 9.741111e-01 0.011 0 0
Formation of the ureteric bud R-HSA-9830674 9.743842e-01 0.011 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.743842e-01 0.011 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.746319e-01 0.011 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.746319e-01 0.011 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.747782e-01 0.011 0 0
Collagen chain trimerization R-HSA-8948216 9.747782e-01 0.011 0 0
Viral mRNA Translation R-HSA-192823 9.749451e-01 0.011 0 0
Mitochondrial protein import R-HSA-1268020 9.764119e-01 0.010 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.773480e-01 0.010 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.773480e-01 0.010 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.773480e-01 0.010 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.774276e-01 0.010 0 0
Complex III assembly R-HSA-9865881 9.774276e-01 0.010 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 9.774276e-01 0.010 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.774276e-01 0.010 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.774276e-01 0.010 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.774276e-01 0.010 0 0
Interleukin-6 family signaling R-HSA-6783589 9.774276e-01 0.010 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.796635e-01 0.009 0 0
Transmission across Chemical Synapses R-HSA-112315 9.797980e-01 0.009 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.801095e-01 0.009 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.801095e-01 0.009 0 0
Formation of the nephric duct R-HSA-9830364 9.801095e-01 0.009 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.801095e-01 0.009 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.801095e-01 0.009 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.815517e-01 0.008 0 0
Glycogen metabolism R-HSA-8982491 9.817486e-01 0.008 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.817486e-01 0.008 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.817486e-01 0.008 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.824730e-01 0.008 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.824730e-01 0.008 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.824730e-01 0.008 0 0
TRP channels R-HSA-3295583 9.824730e-01 0.008 0 0
Abacavir ADME R-HSA-2161522 9.824730e-01 0.008 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.824730e-01 0.008 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 9.824730e-01 0.008 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.825450e-01 0.008 0 0
Diseases of programmed cell death R-HSA-9645723 9.828203e-01 0.008 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.832322e-01 0.007 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.833460e-01 0.007 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.836255e-01 0.007 0 0
Maturation of spike protein R-HSA-9694548 9.836255e-01 0.007 0 0
Regulation of insulin secretion R-HSA-422356 9.838089e-01 0.007 0 0
Translation R-HSA-72766 9.838239e-01 0.007 0 0
PPARA activates gene expression R-HSA-1989781 9.840748e-01 0.007 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.845557e-01 0.007 0 0
Packaging Of Telomere Ends R-HSA-171306 9.845557e-01 0.007 0 0
Insulin processing R-HSA-264876 9.845557e-01 0.007 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.853143e-01 0.006 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.854160e-01 0.006 0 0
G alpha (z) signalling events R-HSA-418597 9.858699e-01 0.006 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.863911e-01 0.006 0 0
Prednisone ADME R-HSA-9757110 9.863911e-01 0.006 0 0
Pyrimidine salvage R-HSA-73614 9.863911e-01 0.006 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 9.868330e-01 0.006 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.868330e-01 0.006 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.868330e-01 0.006 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.868330e-01 0.006 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.872013e-01 0.006 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.880084e-01 0.005 0 0
Defective pyroptosis R-HSA-9710421 9.881983e-01 0.005 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.881983e-01 0.005 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.890323e-01 0.005 0 0
Methylation R-HSA-156581 9.894251e-01 0.005 0 0
Amine ligand-binding receptors R-HSA-375280 9.894251e-01 0.005 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.894336e-01 0.005 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.894336e-01 0.005 0 0
Neurotransmitter clearance R-HSA-112311 9.894336e-01 0.005 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.895115e-01 0.005 0 0
Neuronal System R-HSA-112316 9.898489e-01 0.004 0 0
Hemostasis R-HSA-109582 9.898805e-01 0.004 0 0
Budding and maturation of HIV virion R-HSA-162588 9.906895e-01 0.004 0 0
tRNA Aminoacylation R-HSA-379724 9.914170e-01 0.004 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.916701e-01 0.004 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.916701e-01 0.004 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.916701e-01 0.004 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.917962e-01 0.004 0 0
Platelet homeostasis R-HSA-418346 9.920233e-01 0.003 0 0
Collagen degradation R-HSA-1442490 9.922398e-01 0.003 0 0
Aquaporin-mediated transport R-HSA-445717 9.922398e-01 0.003 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.924049e-01 0.003 0 0
Mitochondrial translation elongation R-HSA-5389840 9.924608e-01 0.003 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.936307e-01 0.003 0 0
CS/DS degradation R-HSA-2024101 9.936307e-01 0.003 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.936307e-01 0.003 0 0
HCMV Infection R-HSA-9609646 9.938443e-01 0.003 0 0
Translation of Structural Proteins R-HSA-9694635 9.940762e-01 0.003 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.943880e-01 0.002 0 0
eNOS activation R-HSA-203615 9.943880e-01 0.002 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.943880e-01 0.002 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.943880e-01 0.002 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.943880e-01 0.002 0 0
Azathioprine ADME R-HSA-9748787 9.945578e-01 0.002 0 0
Interleukin-10 signaling R-HSA-6783783 9.946137e-01 0.002 0 0
Neurotransmitter release cycle R-HSA-112310 9.947483e-01 0.002 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.951048e-01 0.002 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.954326e-01 0.002 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.954326e-01 0.002 0 0
Glycosphingolipid transport R-HSA-9845576 9.956431e-01 0.002 0 0
Protein localization R-HSA-9609507 9.956681e-01 0.002 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.959977e-01 0.002 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.959977e-01 0.002 0 0
Voltage gated Potassium channels R-HSA-1296072 9.961612e-01 0.002 0 0
Cleavage of the damaged purine R-HSA-110331 9.961612e-01 0.002 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.961612e-01 0.002 0 0
Metabolism of folate and pterines R-HSA-196757 9.961612e-01 0.002 0 0
FCGR activation R-HSA-2029481 9.963466e-01 0.002 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.966177e-01 0.001 0 0
Depurination R-HSA-73927 9.966177e-01 0.001 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.966177e-01 0.001 0 0
Collagen formation R-HSA-1474290 9.966662e-01 0.001 0 0
HCMV Late Events R-HSA-9610379 9.967661e-01 0.001 0 0
Paracetamol ADME R-HSA-9753281 9.968920e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.969109e-01 0.001 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.971460e-01 0.001 0 0
Post-translational protein modification R-HSA-597592 9.974074e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.975196e-01 0.001 0 0
G alpha (s) signalling events R-HSA-418555 9.975674e-01 0.001 0 0
Mitochondrial translation initiation R-HSA-5368286 9.979001e-01 0.001 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.979202e-01 0.001 0 0
Translation of Structural Proteins R-HSA-9683701 9.979618e-01 0.001 0 0
Activation of GABAB receptors R-HSA-991365 9.982042e-01 0.001 0 0
GABA B receptor activation R-HSA-977444 9.982042e-01 0.001 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.982042e-01 0.001 0 0
Depyrimidination R-HSA-73928 9.982042e-01 0.001 0 0
RAB geranylgeranylation R-HSA-8873719 9.982342e-01 0.001 0 0
Neddylation R-HSA-8951664 9.985403e-01 0.001 0 0
Viral Infection Pathways R-HSA-9824446 9.985717e-01 0.001 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.986060e-01 0.001 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.987719e-01 0.001 0 0
The canonical retinoid cycle in rods (twilight vision) R-HSA-2453902 9.987719e-01 0.001 0 0
RSV-host interactions R-HSA-9833110 9.989136e-01 0.000 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.989180e-01 0.000 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.989180e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.990023e-01 0.000 0 0
Amyloid fiber formation R-HSA-977225 9.990272e-01 0.000 0 0
Synthesis of PC R-HSA-1483191 9.990467e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.990467e-01 0.000 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.991602e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.992058e-01 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 9.992225e-01 0.000 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.992601e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.992920e-01 0.000 0 0
Regulated Necrosis R-HSA-5218859 9.992920e-01 0.000 0 0
Cardiac conduction R-HSA-5576891 9.993198e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.993267e-01 0.000 0 0
Ion channel transport R-HSA-983712 9.993700e-01 0.000 0 0
The phototransduction cascade R-HSA-2514856 9.994257e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.994257e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.994257e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.994379e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.994880e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.994987e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.995234e-01 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 9.995543e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.996021e-01 0.000 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.996074e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.996541e-01 0.000 0 0
Synthesis of PA R-HSA-1483166 9.997315e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.997771e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.997771e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.997917e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.998016e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.998069e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.998145e-01 0.000 0 0
GABA receptor activation R-HSA-977443 9.998165e-01 0.000 0 0
Stimuli-sensing channels R-HSA-2672351 9.998198e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.998228e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.998383e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.998892e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.998895e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999000e-01 0.000 0 0
Immune System R-HSA-168256 9.999233e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999245e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.999545e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.999545e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999545e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999599e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999647e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.999689e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999689e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999726e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.999726e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999736e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.999810e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999835e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999855e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999872e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.999880e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999880e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999891e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999904e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999941e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999947e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999964e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999972e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999973e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999978e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999981e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999986e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999990e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999993e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999995e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999996e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999997e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999999e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999999e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000e+00 0.000 0 0
Visual phototransduction R-HSA-2187338 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Signaling by BMP R-HSA-201451 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 0 0
Metabolism of RNA R-HSA-8953854 1.132427e-14 13.946 0 0
M Phase R-HSA-68886 2.350342e-13 12.629 0 0
Cell Cycle, Mitotic R-HSA-69278 8.196777e-13 12.086 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.708378e-11 10.567 0 0
Mitotic Anaphase R-HSA-68882 4.232690e-10 9.373 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 4.972964e-10 9.303 0 0
Mitotic Prometaphase R-HSA-68877 2.213711e-09 8.655 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.123056e-09 8.673 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 4.198688e-09 8.377 0 0
Separation of Sister Chromatids R-HSA-2467813 4.133081e-09 8.384 0 0
Aggrephagy R-HSA-9646399 6.916261e-09 8.160 0 0
Interleukin-12 family signaling R-HSA-447115 7.301051e-09 8.137 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.320853e-08 7.879 0 0
Interleukin-12 signaling R-HSA-9020591 1.326026e-08 7.877 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.589767e-08 7.799 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.025003e-08 7.694 0 0
Recycling pathway of L1 R-HSA-437239 2.776530e-08 7.556 0 0
PKR-mediated signaling R-HSA-9833482 1.210450e-07 6.917 0 0
L1CAM interactions R-HSA-373760 1.344584e-07 6.871 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 3.228012e-07 6.491 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 3.228012e-07 6.491 0 0
Signaling downstream of RAS mutants R-HSA-9649948 3.228012e-07 6.491 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.961426e-07 6.528 0 0
Signaling by RAS mutants R-HSA-6802949 3.228012e-07 6.491 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 2.855370e-07 6.544 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.654582e-07 6.576 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 4.276286e-07 6.369 0 0
mRNA Splicing R-HSA-72172 4.157888e-07 6.381 0 0
Cellular responses to stimuli R-HSA-8953897 4.287553e-07 6.368 0 0
mRNA Splicing - Major Pathway R-HSA-72163 4.855681e-07 6.314 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.859848e-07 6.313 0 0
Transport of connexons to the plasma membrane R-HSA-190872 4.808887e-07 6.318 0 0
Cellular responses to stress R-HSA-2262752 7.374934e-07 6.132 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.055703e-06 5.976 0 0
Chromatin organization R-HSA-4839726 1.050100e-06 5.979 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.103266e-06 5.957 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.210715e-06 5.917 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.177229e-06 5.929 0 0
Apoptotic execution phase R-HSA-75153 1.221081e-06 5.913 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.405557e-06 5.852 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.411638e-06 5.850 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.405225e-06 5.852 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.109584e-06 5.676 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 2.430142e-06 5.614 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.564012e-06 5.591 0 0
Cell-Cell communication R-HSA-1500931 2.521962e-06 5.598 0 0
Cell Cycle Checkpoints R-HSA-69620 2.844080e-06 5.546 0 0
Chromatin modifying enzymes R-HSA-3247509 3.461275e-06 5.461 0 0
G2/M Transition R-HSA-69275 4.136295e-06 5.383 0 0
Mitotic G2-G2/M phases R-HSA-453274 5.294628e-06 5.276 0 0
Post NMDA receptor activation events R-HSA-438064 5.872003e-06 5.231 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 6.130960e-06 5.212 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 6.549294e-06 5.184 0 0
Selective autophagy R-HSA-9663891 7.076547e-06 5.150 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 8.338537e-06 5.079 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 8.338537e-06 5.079 0 0
Apoptosis R-HSA-109581 8.724631e-06 5.059 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.141019e-05 4.943 0 0
Kinesins R-HSA-983189 1.218423e-05 4.914 0 0
Cellular response to heat stress R-HSA-3371556 1.353435e-05 4.869 0 0
Striated Muscle Contraction R-HSA-390522 1.546069e-05 4.811 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.700336e-05 4.769 0 0
Signaling by ALK in cancer R-HSA-9700206 1.700336e-05 4.769 0 0
Membrane Trafficking R-HSA-199991 2.121816e-05 4.673 0 0
Axon guidance R-HSA-422475 2.132513e-05 4.671 0 0
Nervous system development R-HSA-9675108 2.187703e-05 4.660 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.505796e-05 4.601 0 0
G2/M Checkpoints R-HSA-69481 3.646902e-05 4.438 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 3.925003e-05 4.406 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 4.701302e-05 4.328 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 4.739981e-05 4.324 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 5.168149e-05 4.287 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 5.587169e-05 4.253 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 6.698189e-05 4.174 0 0
Estrogen-dependent gene expression R-HSA-9018519 6.866519e-05 4.163 0 0
Chaperone Mediated Autophagy R-HSA-9613829 6.871197e-05 4.163 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 7.884740e-05 4.103 0 0
rRNA processing R-HSA-72312 8.189134e-05 4.087 0 0
Programmed Cell Death R-HSA-5357801 7.937655e-05 4.100 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.606281e-05 4.017 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 9.729409e-05 4.012 0 0
Gap junction trafficking and regulation R-HSA-157858 9.739574e-05 4.011 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.063647e-04 3.973 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.137723e-04 3.944 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.175671e-04 3.930 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.271886e-04 3.896 0 0
Cell junction organization R-HSA-446728 1.277383e-04 3.894 0 0
Adherens junctions interactions R-HSA-418990 1.461051e-04 3.835 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.464033e-04 3.834 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.499610e-04 3.824 0 0
MAP2K and MAPK activation R-HSA-5674135 1.601521e-04 3.795 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.686682e-04 3.773 0 0
Autophagy R-HSA-9612973 1.808812e-04 3.743 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.853441e-04 3.732 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.853441e-04 3.732 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.914090e-04 3.718 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.222737e-04 3.653 0 0
Cilium Assembly R-HSA-5617833 2.247993e-04 3.648 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.271309e-04 3.644 0 0
Protein folding R-HSA-391251 2.614675e-04 3.583 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.658817e-04 3.575 0 0
Macroautophagy R-HSA-1632852 2.616403e-04 3.582 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.564245e-04 3.591 0 0
Gap junction assembly R-HSA-190861 2.577801e-04 3.589 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.750323e-04 3.561 0 0
ER to Golgi Anterograde Transport R-HSA-199977 2.778315e-04 3.556 0 0
HDACs deacetylate histones R-HSA-3214815 3.212791e-04 3.493 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.125342e-04 3.505 0 0
Mitotic Prophase R-HSA-68875 3.093973e-04 3.509 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 3.213047e-04 3.493 0 0
Gap junction trafficking R-HSA-190828 3.063828e-04 3.514 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 3.282438e-04 3.484 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 3.282438e-04 3.484 0 0
Interferon Signaling R-HSA-913531 3.451031e-04 3.462 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.448813e-04 3.352 0 0
Regulation of CDH1 Function R-HSA-9764561 4.606343e-04 3.337 0 0
Nuclear Envelope Breakdown R-HSA-2980766 4.606343e-04 3.337 0 0
Ub-specific processing proteases R-HSA-5689880 5.737900e-04 3.241 0 0
Nephrin family interactions R-HSA-373753 5.800298e-04 3.237 0 0
Deubiquitination R-HSA-5688426 5.841607e-04 3.233 0 0
Cytokine Signaling in Immune system R-HSA-1280215 5.899705e-04 3.229 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 7.090720e-04 3.149 0 0
HCMV Early Events R-HSA-9609690 7.258769e-04 3.139 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 7.090720e-04 3.149 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 7.313782e-04 3.136 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 7.090720e-04 3.149 0 0
Cell-cell junction organization R-HSA-421270 7.393166e-04 3.131 0 0
ESR-mediated signaling R-HSA-8939211 7.446635e-04 3.128 0 0
RAF activation R-HSA-5673000 8.250872e-04 3.084 0 0
Eukaryotic Translation Initiation R-HSA-72613 8.555287e-04 3.068 0 0
Cap-dependent Translation Initiation R-HSA-72737 8.555287e-04 3.068 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 8.847094e-04 3.053 0 0
Signaling by Hippo R-HSA-2028269 9.193605e-04 3.037 0 0
Signal Transduction R-HSA-162582 9.333604e-04 3.030 1 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 9.362158e-04 3.029 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.096786e-03 2.960 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.096786e-03 2.960 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.081313e-03 2.966 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.020375e-03 2.991 0 0
HSF1-dependent transactivation R-HSA-3371571 1.144658e-03 2.941 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.166037e-03 2.933 0 0
Centrosome maturation R-HSA-380287 1.245251e-03 2.905 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.245762e-03 2.905 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.309506e-03 2.883 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.439656e-03 2.842 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.453981e-03 2.837 0 0
HIV Life Cycle R-HSA-162587 1.456899e-03 2.837 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.575931e-03 2.802 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.615630e-03 2.792 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.657855e-03 2.780 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 1.693006e-03 2.771 0 0
HIV Infection R-HSA-162906 1.757464e-03 2.755 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.822691e-03 2.739 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.827357e-03 2.738 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.910919e-03 2.719 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.910919e-03 2.719 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.246542e-03 2.648 0 0
RMTs methylate histone arginines R-HSA-3214858 2.404407e-03 2.619 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.411848e-03 2.618 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.422982e-03 2.616 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.692279e-03 2.570 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.785577e-03 2.555 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.785577e-03 2.555 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 3.099655e-03 2.509 0 0
DNA Repair R-HSA-73894 2.969801e-03 2.527 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.831651e-03 2.548 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.034050e-03 2.518 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 3.170262e-03 2.499 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.187558e-03 2.497 0 0
UCH proteinases R-HSA-5689603 3.214810e-03 2.493 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.411564e-03 2.467 0 0
DNA Double-Strand Break Repair R-HSA-5693532 3.423704e-03 2.466 0 0
HSF1 activation R-HSA-3371511 3.585874e-03 2.445 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.593871e-03 2.444 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 3.918620e-03 2.407 0 0
G0 and Early G1 R-HSA-1538133 3.958157e-03 2.403 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 3.958423e-03 2.402 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.958423e-03 2.402 0 0
RNA Polymerase I Transcription R-HSA-73864 4.111325e-03 2.386 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 4.568706e-03 2.340 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 4.274300e-03 2.369 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 4.752626e-03 2.323 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 4.752626e-03 2.323 0 0
Vesicle-mediated transport R-HSA-5653656 4.623968e-03 2.335 0 0
Intraflagellar transport R-HSA-5620924 4.568706e-03 2.340 0 0
Muscle contraction R-HSA-397014 4.708946e-03 2.327 0 0
Amplification of signal from the kinetochores R-HSA-141424 4.942829e-03 2.306 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 4.942829e-03 2.306 0 0
MAPK family signaling cascades R-HSA-5683057 5.057555e-03 2.296 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 5.087293e-03 2.294 0 0
Signaling by SCF-KIT R-HSA-1433557 5.252936e-03 2.280 0 0
HIV elongation arrest and recovery R-HSA-167287 5.253278e-03 2.280 0 0
Pausing and recovery of HIV elongation R-HSA-167290 5.253278e-03 2.280 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 5.731097e-03 2.242 0 0
Cell-extracellular matrix interactions R-HSA-446353 5.763607e-03 2.239 0 0
Viral Infection Pathways R-HSA-9824446 6.130572e-03 2.212 0 0
MHC class II antigen presentation R-HSA-2132295 6.527959e-03 2.185 0 0
Semaphorin interactions R-HSA-373755 6.689239e-03 2.175 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 6.893503e-03 2.162 0 0
Integration of provirus R-HSA-162592 7.024961e-03 2.153 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 7.055593e-03 2.151 0 0
Attenuation phase R-HSA-3371568 7.055593e-03 2.151 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 7.055593e-03 2.151 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 8.068815e-03 2.093 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 7.406613e-03 2.130 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 7.406613e-03 2.130 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 7.865198e-03 2.104 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 8.076609e-03 2.093 0 0
S Phase R-HSA-69242 7.132636e-03 2.147 0 0
Signal transduction by L1 R-HSA-445144 7.406613e-03 2.130 0 0
Hedgehog 'off' state R-HSA-5610787 7.333919e-03 2.135 0 0
Long-term potentiation R-HSA-9620244 8.510275e-03 2.070 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 8.684623e-03 2.061 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 9.012466e-03 2.045 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 9.133545e-03 2.039 0 0
Signaling by Hedgehog R-HSA-5358351 9.135009e-03 2.039 0 0
Early Phase of HIV Life Cycle R-HSA-162594 9.227188e-03 2.035 0 0
Smooth Muscle Contraction R-HSA-445355 9.244523e-03 2.034 0 0
CaM pathway R-HSA-111997 9.498894e-03 2.022 0 0
Calmodulin induced events R-HSA-111933 9.498894e-03 2.022 0 0
RET signaling R-HSA-8853659 9.498894e-03 2.022 0 0
PTEN Regulation R-HSA-6807070 9.878882e-03 2.005 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.941755e-03 2.003 0 0
Chromosome Maintenance R-HSA-73886 9.979907e-03 2.001 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.010251e-02 1.996 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.030518e-02 1.987 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.030518e-02 1.987 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.030518e-02 1.987 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.030518e-02 1.987 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.030518e-02 1.987 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.030518e-02 1.987 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.030518e-02 1.987 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.030518e-02 1.987 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.030518e-02 1.987 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.030518e-02 1.987 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.030518e-02 1.987 0 0
Translation initiation complex formation R-HSA-72649 1.052183e-02 1.978 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.136192e-02 1.945 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.136192e-02 1.945 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.136192e-02 1.945 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.235684e-02 1.908 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.235684e-02 1.908 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.133841e-02 1.945 0 0
Ca-dependent events R-HSA-111996 1.107341e-02 1.956 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.241235e-02 1.906 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.257838e-02 1.900 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.257838e-02 1.900 0 0
HCMV Infection R-HSA-9609646 1.259676e-02 1.900 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.266929e-02 1.897 0 0
Host Interactions of HIV factors R-HSA-162909 1.276115e-02 1.894 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.282342e-02 1.892 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.282342e-02 1.892 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.291473e-02 1.889 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.348755e-02 1.870 0 0
Co-inhibition by PD-1 R-HSA-389948 1.375098e-02 1.862 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.413681e-02 1.850 0 0
Influenza Infection R-HSA-168255 1.485660e-02 1.828 0 0
Signaling by ALK R-HSA-201556 1.493757e-02 1.826 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.493757e-02 1.826 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.501347e-02 1.824 0 0
2-LTR circle formation R-HSA-164843 1.558494e-02 1.807 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.597665e-02 1.797 0 0
DAG and IP3 signaling R-HSA-1489509 1.666009e-02 1.778 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.718986e-02 1.765 0 0
Platelet degranulation R-HSA-114608 1.740199e-02 1.759 0 0
Nuclear import of Rev protein R-HSA-180746 1.747049e-02 1.758 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.102101e-02 1.677 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.102101e-02 1.677 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.102101e-02 1.677 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.102101e-02 1.677 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.102101e-02 1.677 0 0
MET interacts with TNS proteins R-HSA-8875513 1.857121e-02 1.731 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 2.067250e-02 1.685 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.019156e-02 1.695 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.019156e-02 1.695 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 1.862840e-02 1.730 0 0
mRNA 3'-end processing R-HSA-72187 1.803159e-02 1.744 0 0
Meiotic synapsis R-HSA-1221632 2.028378e-02 1.693 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.853422e-02 1.732 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.048851e-02 1.688 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.909803e-02 1.719 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.021194e-02 1.694 0 0
Protein methylation R-HSA-8876725 2.019156e-02 1.695 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.777867e-02 1.750 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.968605e-02 1.706 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.952188e-02 1.709 0 0
Activation of BH3-only proteins R-HSA-114452 2.036625e-02 1.691 0 0
Signaling by Interleukins R-HSA-449147 2.114567e-02 1.675 0 0
DNA Double Strand Break Response R-HSA-5693606 2.206962e-02 1.656 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.230787e-02 1.652 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.259569e-02 1.646 0 0
Nucleotide Excision Repair R-HSA-5696398 2.292742e-02 1.640 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 2.325478e-02 1.633 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.361876e-02 1.627 0 0
PLC beta mediated events R-HSA-112043 2.371740e-02 1.625 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 2.411130e-02 1.618 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.480883e-02 1.605 0 0
Glycolysis R-HSA-70171 2.504101e-02 1.601 0 0
Cellular Senescence R-HSA-2559583 2.504322e-02 1.601 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.591278e-02 1.586 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.591278e-02 1.586 0 0
Recycling of eIF2:GDP R-HSA-72731 2.591278e-02 1.586 0 0
Ribosome-associated quality control R-HSA-9948299 2.612800e-02 1.583 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.631718e-02 1.580 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.661534e-02 1.575 0 0
Gene expression (Transcription) R-HSA-74160 2.713829e-02 1.566 0 0
Basigin interactions R-HSA-210991 2.715568e-02 1.566 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.744959e-02 1.561 0 0
Metalloprotease DUBs R-HSA-5689901 2.774737e-02 1.557 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.830565e-02 1.548 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 2.962462e-02 1.528 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.997121e-02 1.523 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.075321e-02 1.512 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.075321e-02 1.512 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 3.143387e-02 1.503 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.157351e-02 1.501 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.157351e-02 1.501 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.227839e-02 1.491 0 0
Interaction between L1 and Ankyrins R-HSA-445095 3.235011e-02 1.490 0 0
Cristae formation R-HSA-8949613 3.235011e-02 1.490 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 3.243719e-02 1.489 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.285334e-02 1.483 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 3.382832e-02 1.471 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.610893e-02 1.442 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 4.107136e-02 1.386 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.435092e-02 1.464 0 0
HIV Transcription Elongation R-HSA-167169 3.875410e-02 1.412 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.875410e-02 1.412 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.630504e-02 1.440 0 0
Nucleosome assembly R-HSA-774815 3.630504e-02 1.440 0 0
Regulation of PTEN stability and activity R-HSA-8948751 4.167883e-02 1.380 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 4.167883e-02 1.380 0 0
snRNP Assembly R-HSA-191859 3.842660e-02 1.415 0 0
Metabolism of non-coding RNA R-HSA-194441 3.842660e-02 1.415 0 0
mTORC1-mediated signalling R-HSA-166208 3.800911e-02 1.420 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 3.759019e-02 1.425 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.895423e-02 1.409 0 0
Signaling by ERBB2 R-HSA-1227986 4.230790e-02 1.374 0 0
G-protein mediated events R-HSA-112040 4.254648e-02 1.371 0 0
RAF/MAP kinase cascade R-HSA-5673001 4.017225e-02 1.396 0 0
Sodium/Proton exchangers R-HSA-425986 3.487045e-02 1.458 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.875410e-02 1.412 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.988174e-02 1.399 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.800911e-02 1.420 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.630504e-02 1.440 0 0
Late endosomal microautophagy R-HSA-9615710 4.305763e-02 1.366 0 0
SARS-CoV-2-host interactions R-HSA-9705683 4.389326e-02 1.358 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.402321e-02 1.356 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 4.439376e-02 1.353 0 0
Diseases of programmed cell death R-HSA-9645723 4.509025e-02 1.346 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 4.541026e-02 1.343 0 0
Cellular response to mitochondrial stress R-HSA-9840373 4.541026e-02 1.343 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 4.623182e-02 1.335 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 4.645615e-02 1.333 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 4.919578e-02 1.308 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.961368e-02 1.304 0 0
tRNA processing in the nucleus R-HSA-6784531 5.087836e-02 1.293 0 0
Regulation of KIT signaling R-HSA-1433559 5.122923e-02 1.290 0 0
Deadenylation of mRNA R-HSA-429947 5.137613e-02 1.289 0 0
Neurodegenerative Diseases R-HSA-8863678 5.137613e-02 1.289 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 5.137613e-02 1.289 0 0
Neutrophil degranulation R-HSA-6798695 5.327423e-02 1.273 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 5.372285e-02 1.270 0 0
MTOR signalling R-HSA-165159 5.424948e-02 1.266 0 0
Degradation of CDH1 R-HSA-9766229 5.528548e-02 1.257 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 5.567313e-02 1.254 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 5.587442e-02 1.253 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 5.587442e-02 1.253 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 5.587442e-02 1.253 0 0
Folding of actin by CCT/TriC R-HSA-390450 5.753298e-02 1.240 0 0
PI3K/AKT activation R-HSA-198203 5.753298e-02 1.240 0 0
Meiosis R-HSA-1500620 5.770546e-02 1.239 0 0
Platelet activation, signaling and aggregation R-HSA-76002 5.825870e-02 1.235 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 5.864869e-02 1.232 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.864869e-02 1.232 0 0
Signaling by Nuclear Receptors R-HSA-9006931 5.891158e-02 1.230 0 0
HDMs demethylate histones R-HSA-3214842 5.904226e-02 1.229 0 0
Clathrin-mediated endocytosis R-HSA-8856828 5.964279e-02 1.224 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 5.983856e-02 1.223 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 5.983856e-02 1.223 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.993260e-02 1.222 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 5.993260e-02 1.222 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 6.060036e-02 1.218 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 6.129774e-02 1.213 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 6.157038e-02 1.211 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 6.157038e-02 1.211 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 6.157038e-02 1.211 0 0
Signaling by TGFB family members R-HSA-9006936 6.486283e-02 1.188 1 0
Homology Directed Repair R-HSA-5693538 6.504640e-02 1.187 0 0
Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) R-HSA-1299308 7.289682e-02 1.137 0 0
Signaling by LTK in cancer R-HSA-9842640 7.889571e-02 1.103 0 0
Chylomicron clearance R-HSA-8964026 7.889571e-02 1.103 0 0
PECAM1 interactions R-HSA-210990 7.121072e-02 1.147 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 7.300392e-02 1.137 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 7.300392e-02 1.137 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 7.300392e-02 1.137 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 8.551287e-02 1.068 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.605396e-02 1.065 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.605396e-02 1.065 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 7.088801e-02 1.149 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 7.336050e-02 1.135 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 7.336050e-02 1.135 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 8.056143e-02 1.094 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 8.056143e-02 1.094 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 7.322033e-02 1.135 0 0
Orc1 removal from chromatin R-HSA-68949 7.322033e-02 1.135 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 7.322033e-02 1.135 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 6.657829e-02 1.177 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 7.993297e-02 1.097 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 7.993297e-02 1.097 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 6.677732e-02 1.175 0 0
Formation of a pool of free 40S subunits R-HSA-72689 8.467173e-02 1.072 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 8.701739e-02 1.060 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 6.847947e-02 1.164 0 0
Protein ubiquitination R-HSA-8852135 8.134406e-02 1.090 0 0
DNA Replication Pre-Initiation R-HSA-69002 8.366274e-02 1.077 0 0
Assembly of the pre-replicative complex R-HSA-68867 6.958622e-02 1.157 0 0
Disorders of Developmental Biology R-HSA-9675151 8.551287e-02 1.068 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 8.551287e-02 1.068 0 0
Signaling by VEGF R-HSA-194138 6.659530e-02 1.177 0 0
Prolonged ERK activation events R-HSA-169893 7.300392e-02 1.137 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 8.639053e-02 1.064 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 8.140254e-02 1.089 0 0
Signaling by PDGFR in disease R-HSA-9671555 8.153079e-02 1.089 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 8.639053e-02 1.064 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 7.088801e-02 1.149 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 7.923262e-02 1.101 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 8.056143e-02 1.094 0 0
Gene Silencing by RNA R-HSA-211000 7.414357e-02 1.130 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 7.638004e-02 1.117 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 7.088801e-02 1.149 0 0
Unfolded Protein Response (UPR) R-HSA-381119 6.913209e-02 1.160 0 0
Signaling by ROBO receptors R-HSA-376176 8.089303e-02 1.092 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 8.818186e-02 1.055 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 8.866790e-02 1.052 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 8.866790e-02 1.052 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.866790e-02 1.052 0 0
Developmental Biology R-HSA-1266738 9.178377e-02 1.037 0 0
Response of endothelial cells to shear stress R-HSA-9860931 9.220957e-02 1.035 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.220957e-02 1.035 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.233657e-02 1.035 0 0
FGFR2 alternative splicing R-HSA-6803529 9.288414e-02 1.032 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.288414e-02 1.032 0 0
Signaling by KIT in disease R-HSA-9669938 9.288414e-02 1.032 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.447440e-02 1.025 0 0
PIP3 activates AKT signaling R-HSA-1257604 9.484796e-02 1.023 0 0
Regulation of TP53 Activity R-HSA-5633007 9.530801e-02 1.021 0 0
Glucose metabolism R-HSA-70326 9.540349e-02 1.020 0 0
Telomere Maintenance R-HSA-157579 9.582271e-02 1.019 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.583738e-02 1.018 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 9.672906e-02 1.014 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 9.759820e-02 1.011 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 9.906858e-02 1.004 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 9.906858e-02 1.004 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 9.906858e-02 1.004 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.938502e-02 1.003 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.938502e-02 1.003 0 0
IRE1alpha activates chaperones R-HSA-381070 9.954286e-02 1.002 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 1.001122e-01 1.000 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 1.001122e-01 1.000 0 0
TRIF-mediated programmed cell death R-HSA-2562578 1.001122e-01 1.000 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.001122e-01 1.000 0 0
CHL1 interactions R-HSA-447041 1.001122e-01 1.000 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.001122e-01 1.000 0 0
G1/S Transition R-HSA-69206 1.018002e-01 0.992 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.023035e-01 0.990 0 0
Signaling by EGFR R-HSA-177929 1.023035e-01 0.990 0 0
Scavenging by Class F Receptors R-HSA-3000484 1.029983e-01 0.987 0 0
Repression of WNT target genes R-HSA-4641265 1.029983e-01 0.987 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.029983e-01 0.987 0 0
Signaling by LTK R-HSA-9842663 1.029983e-01 0.987 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.038138e-01 0.984 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.038138e-01 0.984 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.044287e-01 0.981 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.044287e-01 0.981 0 0
Syndecan interactions R-HSA-3000170 1.050420e-01 0.979 0 0
EPH-Ephrin signaling R-HSA-2682334 1.058308e-01 0.975 0 0
MET activates STAT3 R-HSA-8875791 1.061661e-01 0.974 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 1.061661e-01 0.974 0 0
MET activates PTPN11 R-HSA-8865999 1.061661e-01 0.974 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 1.061661e-01 0.974 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.065478e-01 0.972 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.073836e-01 0.969 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.073836e-01 0.969 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 1.073836e-01 0.969 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.076102e-01 0.968 0 0
HATs acetylate histones R-HSA-3214847 1.078582e-01 0.967 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.100664e-01 0.958 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.100806e-01 0.958 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.108387e-01 0.955 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.108387e-01 0.955 0 0
GAB1 signalosome R-HSA-180292 1.136320e-01 0.944 0 0
Polo-like kinase mediated events R-HSA-156711 1.136320e-01 0.944 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.136320e-01 0.944 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.136320e-01 0.944 0 0
Synthesis of DNA R-HSA-69239 1.156900e-01 0.937 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 1.161953e-01 0.935 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.179814e-01 0.928 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.190150e-01 0.924 0 0
Trafficking of AMPA receptors R-HSA-399719 1.190150e-01 0.924 0 0
Frs2-mediated activation R-HSA-170968 1.209425e-01 0.917 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.209425e-01 0.917 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.214558e-01 0.916 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.218729e-01 0.914 0 0
Hedgehog ligand biogenesis R-HSA-5358346 1.228331e-01 0.911 0 0
Interleukin-18 signaling R-HSA-9012546 1.233270e-01 0.909 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.233270e-01 0.909 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.233270e-01 0.909 0 0
Peptide chain elongation R-HSA-156902 1.242455e-01 0.906 0 0
SARS-CoV Infections R-HSA-9679506 1.268824e-01 0.897 0 0
Regulation of gap junction activity R-HSA-191650 1.425991e-01 0.846 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.425991e-01 0.846 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 1.425991e-01 0.846 0 0
Signaling by MAP2K mutants R-HSA-9652169 1.425991e-01 0.846 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 1.811732e-01 0.742 0 0
IRS activation R-HSA-74713 1.811732e-01 0.742 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 1.811732e-01 0.742 0 0
ARMS-mediated activation R-HSA-170984 1.482696e-01 0.829 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 1.604086e-01 0.795 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 1.455802e-01 0.837 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 1.816920e-01 0.741 0 0
Phosphorylation of the APC/C R-HSA-176412 1.816920e-01 0.741 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.628456e-01 0.788 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.628456e-01 0.788 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.628456e-01 0.788 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.808823e-01 0.743 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.611759e-01 0.793 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.932250e-01 0.714 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.529444e-01 0.815 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.325172e-01 0.878 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.478686e-01 0.830 0 0
Transcription of the HIV genome R-HSA-167172 1.409420e-01 0.851 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.597108e-01 0.797 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.473951e-01 0.832 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.325172e-01 0.878 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.597108e-01 0.797 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.575476e-01 0.803 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.796779e-01 0.746 0 0
DCC mediated attractive signaling R-HSA-418885 1.604086e-01 0.795 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.441205e-01 0.841 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.785544e-01 0.748 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.597108e-01 0.797 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.711373e-01 0.767 0 0
Regulation of CDH11 function R-HSA-9762292 1.746650e-01 0.758 0 0
Nuclear RNA decay R-HSA-9930044 1.441205e-01 0.841 0 0
Regulation of Apoptosis R-HSA-169911 1.860094e-01 0.730 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.425991e-01 0.846 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 1.482696e-01 0.829 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 1.611759e-01 0.793 0 0
Translation R-HSA-72766 1.297027e-01 0.887 0 0
Pyrophosphate hydrolysis R-HSA-71737 1.811732e-01 0.742 0 0
Calcineurin activates NFAT R-HSA-2025928 1.482696e-01 0.829 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 1.529444e-01 0.815 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.932250e-01 0.714 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.409420e-01 0.851 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.820101e-01 0.740 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 1.425991e-01 0.846 0 0
Stabilization of p53 R-HSA-69541 1.408469e-01 0.851 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 1.592974e-01 0.798 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.417993e-01 0.848 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.303981e-01 0.885 0 0
Post-translational protein modification R-HSA-597592 1.913447e-01 0.718 0 0
Formation of the anterior neural plate R-HSA-9823739 1.604086e-01 0.795 0 0
Unwinding of DNA R-HSA-176974 1.482696e-01 0.829 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 1.769047e-01 0.752 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.469193e-01 0.833 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.833714e-01 0.737 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.833714e-01 0.737 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.864928e-01 0.729 0 0
Ion homeostasis R-HSA-5578775 1.750928e-01 0.757 0 0
ABC-family proteins mediated transport R-HSA-382556 1.729077e-01 0.762 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 1.604086e-01 0.795 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 1.604086e-01 0.795 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 1.529444e-01 0.815 0 0
Interleukin-27 signaling R-HSA-9020956 1.746650e-01 0.758 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.874688e-01 0.727 0 0
Signaling by Leptin R-HSA-2586552 1.746650e-01 0.758 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 1.425991e-01 0.846 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 1.441205e-01 0.841 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.441205e-01 0.841 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.441205e-01 0.841 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.460847e-01 0.835 0 0
Gluconeogenesis R-HSA-70263 1.711373e-01 0.767 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.746650e-01 0.758 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.409420e-01 0.851 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.655208e-01 0.781 0 0
Interleukin-7 signaling R-HSA-1266695 1.316737e-01 0.881 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.291546e-01 0.889 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.361522e-01 0.866 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.750928e-01 0.757 0 0
DNA Replication R-HSA-69306 1.963591e-01 0.707 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.979575e-01 0.703 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 1.979575e-01 0.703 0 0
Hereditary fructose intolerance R-HSA-5657560 1.979575e-01 0.703 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.979575e-01 0.703 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.979575e-01 0.703 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.979575e-01 0.703 0 0
Activation and oligomerization of BAK protein R-HSA-111452 1.979575e-01 0.703 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 1.979575e-01 0.703 0 0
Inhibition of PKR R-HSA-169131 1.979575e-01 0.703 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 1.996176e-01 0.700 0 0
Notch-HLH transcription pathway R-HSA-350054 1.996176e-01 0.700 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 2.009798e-01 0.697 0 0
RNA Polymerase III Transcription R-HSA-74158 2.009798e-01 0.697 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 2.009798e-01 0.697 0 0
G1/S-Specific Transcription R-HSA-69205 2.009798e-01 0.697 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 2.022412e-01 0.694 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.022412e-01 0.694 0 0
Chylomicron assembly R-HSA-8963888 2.022412e-01 0.694 0 0
Formation of the posterior neural plate R-HSA-9832991 2.022412e-01 0.694 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.038409e-01 0.691 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 2.058974e-01 0.686 0 0
Defective pyroptosis R-HSA-9710421 2.058974e-01 0.686 0 0
Opioid Signalling R-HSA-111885 2.083917e-01 0.681 0 0
Activation of the pre-replicative complex R-HSA-68962 2.100880e-01 0.678 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.100880e-01 0.678 0 0
Extension of Telomeres R-HSA-180786 2.107058e-01 0.676 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.107058e-01 0.676 0 0
RNA Polymerase II Transcription R-HSA-73857 2.118324e-01 0.674 0 0
Developmental Cell Lineages R-HSA-9734767 2.158314e-01 0.666 0 0
Degradation of DVL R-HSA-4641258 2.163967e-01 0.665 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.177499e-01 0.662 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.177499e-01 0.662 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.189757e-01 0.660 0 0
Growth hormone receptor signaling R-HSA-982772 2.189757e-01 0.660 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.193835e-01 0.659 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.201544e-01 0.657 0 0
Proteasome assembly R-HSA-9907900 2.201544e-01 0.657 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 2.210444e-01 0.656 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.210444e-01 0.656 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 2.210444e-01 0.656 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.210444e-01 0.656 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 2.210444e-01 0.656 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 2.210444e-01 0.656 0 0
Proton/oligopeptide cotransporters R-HSA-427975 2.210444e-01 0.656 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.210444e-01 0.656 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.220274e-01 0.654 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 2.222454e-01 0.653 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 2.267263e-01 0.644 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.267263e-01 0.644 0 0
Uptake and function of anthrax toxins R-HSA-5210891 2.267263e-01 0.644 0 0
Downstream signal transduction R-HSA-186763 2.274425e-01 0.643 0 0
Post-translational protein phosphorylation R-HSA-8957275 2.293232e-01 0.640 0 0
Hemostasis R-HSA-109582 2.299541e-01 0.638 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.307354e-01 0.637 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 2.307354e-01 0.637 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.817236e-01 0.550 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 2.817236e-01 0.550 0 0
IKBKB deficiency causes SCID R-HSA-5602636 2.817236e-01 0.550 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 2.817236e-01 0.550 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.817236e-01 0.550 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.817236e-01 0.550 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 2.817236e-01 0.550 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.817236e-01 0.550 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.817236e-01 0.550 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.567455e-01 0.448 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.567455e-01 0.448 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.567455e-01 0.448 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.567455e-01 0.448 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.567455e-01 0.448 0 0
VLDL assembly R-HSA-8866423 2.615218e-01 0.582 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.615218e-01 0.582 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 3.020442e-01 0.520 0 0
LDL remodeling R-HSA-8964041 3.020442e-01 0.520 0 0
SOS-mediated signalling R-HSA-112412 3.020442e-01 0.520 0 0
Disinhibition of SNARE formation R-HSA-114516 3.020442e-01 0.520 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.239355e-01 0.373 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.239355e-01 0.373 0 0
Signalling to STAT3 R-HSA-198745 4.239355e-01 0.373 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 4.239355e-01 0.373 0 0
Defective HPRT1 disrupts guanine and hypoxanthine salvage R-HSA-9734281 4.239355e-01 0.373 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 2.598987e-01 0.585 0 0
Type I hemidesmosome assembly R-HSA-446107 3.421610e-01 0.466 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 3.421610e-01 0.466 0 0
MET receptor recycling R-HSA-8875656 3.421610e-01 0.466 0 0
Formation of annular gap junctions R-HSA-196025 3.421610e-01 0.466 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.894985e-01 0.538 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 2.894985e-01 0.538 0 0
Formation of axial mesoderm R-HSA-9796292 2.894985e-01 0.538 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 2.894985e-01 0.538 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 2.894985e-01 0.538 0 0
Ephrin signaling R-HSA-3928664 2.502192e-01 0.602 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.388789e-01 0.622 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.741932e-01 0.562 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 2.741932e-01 0.562 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.741932e-01 0.562 0 0
Lipophagy R-HSA-9613354 3.815152e-01 0.418 0 0
Gap junction degradation R-HSA-190873 3.815152e-01 0.418 0 0
WNT mediated activation of DVL R-HSA-201688 3.815152e-01 0.418 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 3.815152e-01 0.418 0 0
ALK mutants bind TKIs R-HSA-9700645 3.815152e-01 0.418 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.985252e-01 0.525 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.985252e-01 0.525 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.985252e-01 0.525 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.985252e-01 0.525 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 3.491714e-01 0.457 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.800060e-01 0.553 0 0
Binding and entry of HIV virion R-HSA-173107 4.198286e-01 0.377 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 4.198286e-01 0.377 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 2.484205e-01 0.605 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 3.477971e-01 0.459 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 3.477971e-01 0.459 0 0
Telomere Extension By Telomerase R-HSA-171319 3.223740e-01 0.492 0 0
mRNA Capping R-HSA-72086 3.438340e-01 0.464 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.438340e-01 0.464 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.725194e-01 0.429 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 4.082781e-01 0.389 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 2.783282e-01 0.555 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.653817e-01 0.437 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 3.971661e-01 0.401 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 3.971661e-01 0.401 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 4.372439e-01 0.359 0 0
MET promotes cell motility R-HSA-8875878 3.775470e-01 0.423 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.216465e-01 0.375 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 4.216465e-01 0.375 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 3.121658e-01 0.506 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.656559e-01 0.332 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.458722e-01 0.461 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 4.458779e-01 0.351 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 4.458779e-01 0.351 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 3.760145e-01 0.425 0 0
Dual incision in TC-NER R-HSA-6782135 4.428882e-01 0.354 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 4.406918e-01 0.356 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 2.439811e-01 0.613 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 4.547018e-01 0.342 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 2.649496e-01 0.577 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 2.649496e-01 0.577 0 0
DARPP-32 events R-HSA-180024 3.438340e-01 0.464 0 0
Platelet sensitization by LDL R-HSA-432142 2.502192e-01 0.602 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.800060e-01 0.553 0 0
DNA Damage Bypass R-HSA-73893 4.396993e-01 0.357 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.366325e-01 0.360 0 0
Integrin signaling R-HSA-354192 2.634143e-01 0.579 0 0
DNA strand elongation R-HSA-69190 2.452359e-01 0.610 0 0
Fanconi Anemia Pathway R-HSA-6783310 3.688358e-01 0.433 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 3.511611e-01 0.454 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.815152e-01 0.418 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.198286e-01 0.377 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.688358e-01 0.433 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.649496e-01 0.577 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 3.725194e-01 0.429 0 0
Eukaryotic Translation Termination R-HSA-72764 2.858356e-01 0.544 0 0
Myogenesis R-HSA-525793 2.800060e-01 0.553 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.007090e-01 0.522 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 3.688358e-01 0.433 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.388935e-01 0.470 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 2.598987e-01 0.585 0 0
Regulation of IFNG signaling R-HSA-877312 2.598987e-01 0.585 0 0
Translesion Synthesis by POLH R-HSA-110320 2.741932e-01 0.562 0 0
PKA activation R-HSA-163615 4.656559e-01 0.332 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 4.656559e-01 0.332 0 0
TGFBR3 expression R-HSA-9839394 4.458779e-01 0.351 0 0
COPII-mediated vesicle transport R-HSA-204005 3.602645e-01 0.443 0 0
Cellular response to starvation R-HSA-9711097 3.066365e-01 0.513 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.421610e-01 0.466 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 2.817703e-01 0.550 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.971661e-01 0.401 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.173966e-01 0.498 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 4.298857e-01 0.367 0 0
PI3K Cascade R-HSA-109704 4.572804e-01 0.340 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.969242e-01 0.401 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 2.819235e-01 0.550 0 0
ER-Phagosome pathway R-HSA-1236974 2.901417e-01 0.537 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 3.010732e-01 0.521 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.800060e-01 0.553 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.598987e-01 0.585 0 0
Pervasive developmental disorders R-HSA-9005895 2.598987e-01 0.585 0 0
Disorders of Nervous System Development R-HSA-9697154 2.598987e-01 0.585 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 3.421610e-01 0.466 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 2.985252e-01 0.525 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 4.198286e-01 0.377 0 0
Interleukin-23 signaling R-HSA-9020933 3.421610e-01 0.466 0 0
Signaling by WNT R-HSA-195721 4.601130e-01 0.337 0 0
Plasma lipoprotein assembly R-HSA-8963898 4.216465e-01 0.375 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.634143e-01 0.579 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.615218e-01 0.582 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.421610e-01 0.466 0 0
Rap1 signalling R-HSA-392517 2.741932e-01 0.562 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 2.347646e-01 0.629 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 4.082781e-01 0.389 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.581871e-01 0.446 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.248253e-01 0.488 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 3.020442e-01 0.520 0 0
Degradation of CRY and PER proteins R-HSA-9932298 2.988422e-01 0.525 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 2.741932e-01 0.562 0 0
Interleukin-35 Signalling R-HSA-8984722 2.598987e-01 0.585 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.725194e-01 0.429 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 3.331749e-01 0.477 0 0
Signaling by FGFR1 in disease R-HSA-5655302 4.547018e-01 0.342 0 0
Manipulation of host energy metabolism R-HSA-9636667 2.817236e-01 0.550 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.567455e-01 0.448 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.567455e-01 0.448 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 4.239355e-01 0.373 0 0
Co-stimulation by ICOS R-HSA-9927354 3.421610e-01 0.466 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 2.741932e-01 0.562 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 3.815152e-01 0.418 0 0
Bicarbonate transporters R-HSA-425381 4.568895e-01 0.340 0 0
vRNP Assembly R-HSA-192905 4.568895e-01 0.340 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.458779e-01 0.351 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 4.458779e-01 0.351 0 0
TCR signaling R-HSA-202403 3.718287e-01 0.430 0 0
FGFR1 mutant receptor activation R-HSA-1839124 4.298857e-01 0.367 0 0
Cellular response to chemical stress R-HSA-9711123 3.044193e-01 0.517 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.988422e-01 0.525 0 0
Signalling to ERKs R-HSA-187687 3.197167e-01 0.495 0 0
Death Receptor Signaling R-HSA-73887 4.366325e-01 0.360 0 0
Interleukin-9 signaling R-HSA-8985947 3.421610e-01 0.466 0 0
PCP/CE pathway R-HSA-4086400 3.526417e-01 0.453 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.708328e-01 0.567 0 0
Signaling by NOTCH R-HSA-157118 2.899547e-01 0.538 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 4.012154e-01 0.397 0 0
Signaling by TGFBR3 R-HSA-9839373 3.865635e-01 0.413 0 0
Transmission across Chemical Synapses R-HSA-112315 4.458680e-01 0.351 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.815152e-01 0.418 0 0
Signal attenuation R-HSA-74749 4.198286e-01 0.377 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 2.536409e-01 0.596 0 0
Gastrulation R-HSA-9758941 3.862822e-01 0.413 0 0
Nef and signal transduction R-HSA-164944 2.615218e-01 0.582 0 0
Specification of the neural plate border R-HSA-9834899 2.741932e-01 0.562 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.815152e-01 0.418 0 0
Interleukin-21 signaling R-HSA-9020958 3.815152e-01 0.418 0 0
Interleukin-1 processing R-HSA-448706 3.815152e-01 0.418 0 0
Protein hydroxylation R-HSA-9629569 2.985252e-01 0.525 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 2.988422e-01 0.525 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 2.988422e-01 0.525 0 0
Synthesis of PG R-HSA-1483148 4.082781e-01 0.389 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 3.602645e-01 0.443 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 3.837672e-01 0.416 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.817703e-01 0.550 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.552578e-01 0.593 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.407434e-01 0.618 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.020442e-01 0.520 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.683901e-01 0.434 0 0
Signaling by PDGF R-HSA-186797 3.683901e-01 0.434 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.038071e-01 0.394 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 3.971661e-01 0.401 0 0
Signaling by ERBB4 R-HSA-1236394 4.183744e-01 0.378 0 0
Reproduction R-HSA-1474165 3.498570e-01 0.456 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 3.321441e-01 0.479 0 0
Interleukin-1 signaling R-HSA-9020702 4.644186e-01 0.333 0 0
Inhibition of membrane repair R-HSA-9635644 2.817236e-01 0.550 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.615218e-01 0.582 0 0
SLC-mediated transport of oligopeptides R-HSA-9959399 3.020442e-01 0.520 0 0
Intracellular oxygen transport R-HSA-8981607 4.239355e-01 0.373 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 4.239355e-01 0.373 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.452359e-01 0.610 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 2.452359e-01 0.610 0 0
Josephin domain DUBs R-HSA-5689877 4.198286e-01 0.377 0 0
Activation of SMO R-HSA-5635838 3.788754e-01 0.422 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 2.649496e-01 0.577 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 3.197167e-01 0.495 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 3.197167e-01 0.495 0 0
Interleukin-2 family signaling R-HSA-451927 4.162718e-01 0.381 0 0
Somitogenesis R-HSA-9824272 3.688358e-01 0.433 0 0
Interleukin-1 family signaling R-HSA-446652 3.307102e-01 0.481 0 0
Interleukin-6 signaling R-HSA-1059683 2.894985e-01 0.538 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 4.511372e-01 0.346 0 0
Receptor Mediated Mitophagy R-HSA-8934903 4.198286e-01 0.377 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 2.484205e-01 0.605 0 0
Suppression of apoptosis R-HSA-9635465 4.568895e-01 0.340 0 0
Selenocysteine synthesis R-HSA-2408557 4.644186e-01 0.333 0 0
Signaling by FGFR in disease R-HSA-1226099 4.183744e-01 0.378 0 0
Inositol phosphate metabolism R-HSA-1483249 2.985018e-01 0.525 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 3.567455e-01 0.448 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 3.020442e-01 0.520 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 3.020442e-01 0.520 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 4.239355e-01 0.373 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.198286e-01 0.377 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 2.484205e-01 0.605 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 3.388935e-01 0.470 0 0
Degradation of AXIN R-HSA-4641257 3.581871e-01 0.446 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 3.581871e-01 0.446 0 0
Signaling by NOTCH4 R-HSA-9013694 2.989242e-01 0.524 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 4.656559e-01 0.332 0 0
Sensory processing of sound R-HSA-9659379 2.578301e-01 0.589 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.568895e-01 0.340 0 0
Potential therapeutics for SARS R-HSA-9679191 3.963075e-01 0.402 0 0
Hedgehog 'on' state R-HSA-5632684 3.747317e-01 0.426 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 3.567455e-01 0.448 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 3.020442e-01 0.520 0 0
Expression and Processing of Neurotrophins R-HSA-9036866 4.239355e-01 0.373 0 0
NGF processing R-HSA-167060 4.239355e-01 0.373 0 0
Signal regulatory protein family interactions R-HSA-391160 3.193209e-01 0.496 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.815152e-01 0.418 0 0
Vpu mediated degradation of CD4 R-HSA-180534 2.819235e-01 0.550 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 3.007090e-01 0.522 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 3.007090e-01 0.522 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 3.477971e-01 0.459 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 3.688358e-01 0.433 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 3.688358e-01 0.433 0 0
Metal ion SLC transporters R-HSA-425410 4.220305e-01 0.375 0 0
Tandem pore domain potassium channels R-HSA-1296346 4.198286e-01 0.377 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 4.082781e-01 0.389 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.568895e-01 0.340 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 2.894985e-01 0.538 0 0
Interleukin-37 signaling R-HSA-9008059 3.653817e-01 0.437 0 0
Tie2 Signaling R-HSA-210993 4.656559e-01 0.332 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 4.372439e-01 0.359 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 3.193209e-01 0.496 0 0
Synthesis and processing of ENV and VPU R-HSA-171286 3.567455e-01 0.448 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 3.969242e-01 0.401 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 4.302896e-01 0.366 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 4.697853e-01 0.328 0 0
MET activates PTK2 signaling R-HSA-8874081 4.697853e-01 0.328 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.697853e-01 0.328 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 4.697853e-01 0.328 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 4.697853e-01 0.328 0 0
TRP channels R-HSA-3295583 4.697853e-01 0.328 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 4.721722e-01 0.326 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 4.721722e-01 0.326 0 0
Dual Incision in GG-NER R-HSA-5696400 4.721722e-01 0.326 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 4.721722e-01 0.326 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 4.721722e-01 0.326 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 4.721722e-01 0.326 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 4.747423e-01 0.324 0 0
Meiotic recombination R-HSA-912446 4.747423e-01 0.324 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 4.747423e-01 0.324 0 0
ABC transporter disorders R-HSA-5619084 4.763843e-01 0.322 0 0
Mitochondrial biogenesis R-HSA-1592230 4.771264e-01 0.321 0 0
Metabolism of proteins R-HSA-392499 4.838320e-01 0.315 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.841108e-01 0.315 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.841108e-01 0.315 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.841108e-01 0.315 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.841108e-01 0.315 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.841108e-01 0.315 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.841108e-01 0.315 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 4.841108e-01 0.315 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.841108e-01 0.315 0 0
NADE modulates death signalling R-HSA-205025 4.841108e-01 0.315 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.841108e-01 0.315 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 4.841108e-01 0.315 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 4.887612e-01 0.311 0 0
Viral mRNA Translation R-HSA-192823 4.895134e-01 0.310 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 4.916036e-01 0.308 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 4.925415e-01 0.308 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.925415e-01 0.308 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.925415e-01 0.308 0 0
Signaling by GSK3beta mutants R-HSA-5339716 4.925415e-01 0.308 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 4.925415e-01 0.308 0 0
NF-kB is activated and signals survival R-HSA-209560 4.925415e-01 0.308 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 4.925415e-01 0.308 0 0
PERK regulates gene expression R-HSA-381042 4.929420e-01 0.307 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 4.929420e-01 0.307 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.933016e-01 0.307 0 0
Packaging Of Telomere Ends R-HSA-171306 4.933016e-01 0.307 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 4.933016e-01 0.307 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.933016e-01 0.307 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 4.933016e-01 0.307 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 4.934144e-01 0.307 0 0
The NLRP3 inflammasome R-HSA-844456 4.934144e-01 0.307 0 0
Other interleukin signaling R-HSA-449836 4.934144e-01 0.307 0 0
Maturation of nucleoprotein R-HSA-9694631 4.934144e-01 0.307 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 4.934144e-01 0.307 0 0
Generic Transcription Pathway R-HSA-212436 4.952804e-01 0.305 0 0
Signaling by MET R-HSA-6806834 5.049779e-01 0.297 0 0
Signaling by FGFR2 R-HSA-5654738 5.049779e-01 0.297 0 0
Heme signaling R-HSA-9707616 5.075903e-01 0.294 0 0
Cyclin D associated events in G1 R-HSA-69231 5.110863e-01 0.292 0 0
G1 Phase R-HSA-69236 5.110863e-01 0.292 0 0
FLT3 signaling in disease R-HSA-9682385 5.134022e-01 0.290 0 0
GPVI-mediated activation cascade R-HSA-114604 5.134022e-01 0.290 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 5.163675e-01 0.287 0 0
Amyloid fiber formation R-HSA-977225 5.191125e-01 0.285 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 5.204361e-01 0.284 0 0
Negative regulation of MET activity R-HSA-6807004 5.204361e-01 0.284 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 5.204361e-01 0.284 0 0
Formation of definitive endoderm R-HSA-9823730 5.204361e-01 0.284 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 5.266746e-01 0.278 0 0
Polymerase switching R-HSA-69091 5.266746e-01 0.278 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 5.266746e-01 0.278 0 0
Leading Strand Synthesis R-HSA-69109 5.266746e-01 0.278 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 5.266746e-01 0.278 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 5.266746e-01 0.278 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 5.266746e-01 0.278 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 5.266746e-01 0.278 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 5.266746e-01 0.278 0 0
p75NTR recruits signalling complexes R-HSA-209543 5.266746e-01 0.278 0 0
Interleukin-15 signaling R-HSA-8983432 5.266746e-01 0.278 0 0
OAS antiviral response R-HSA-8983711 5.266746e-01 0.278 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 5.266746e-01 0.278 0 0
Downstream TCR signaling R-HSA-202424 5.307128e-01 0.275 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 5.331184e-01 0.273 0 0
Ca2+ pathway R-HSA-4086398 5.358650e-01 0.271 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 5.380035e-01 0.269 0 0
G2 Phase R-HSA-68911 5.380035e-01 0.269 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.380035e-01 0.269 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.380035e-01 0.269 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 5.380035e-01 0.269 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.380035e-01 0.269 0 0
Defective F9 activation R-HSA-9673221 5.380035e-01 0.269 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.380035e-01 0.269 0 0
Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) R-HSA-5619067 5.380035e-01 0.269 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 5.380035e-01 0.269 0 0
PTK6 Activates STAT3 R-HSA-8849474 5.380035e-01 0.269 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.380035e-01 0.269 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 5.380035e-01 0.269 0 0
Activation of AKT2 R-HSA-165158 5.380035e-01 0.269 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.380035e-01 0.269 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 5.380035e-01 0.269 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.380035e-01 0.269 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.380035e-01 0.269 0 0
NrCAM interactions R-HSA-447038 5.380035e-01 0.269 0 0
Co-inhibition by BTLA R-HSA-9927353 5.380035e-01 0.269 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 5.380035e-01 0.269 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 5.380035e-01 0.269 0 0
DNA methylation R-HSA-5334118 5.389311e-01 0.268 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 5.389311e-01 0.268 0 0
IGF1R signaling cascade R-HSA-2428924 5.390534e-01 0.268 0 0
Adaptive Immune System R-HSA-1280218 5.393740e-01 0.268 0 0
Lagging Strand Synthesis R-HSA-69186 5.466527e-01 0.262 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 5.466527e-01 0.262 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 5.466527e-01 0.262 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 5.474321e-01 0.262 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 5.474321e-01 0.262 0 0
Regulation of TNFR1 signaling R-HSA-5357905 5.474321e-01 0.262 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 5.532377e-01 0.257 0 0
FOXO-mediated transcription R-HSA-9614085 5.538408e-01 0.257 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 5.544901e-01 0.256 0 0
Chylomicron remodeling R-HSA-8963901 5.592173e-01 0.252 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 5.592173e-01 0.252 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 5.592173e-01 0.252 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 5.592173e-01 0.252 0 0
Maturation of nucleoprotein R-HSA-9683610 5.592173e-01 0.252 0 0
TNF signaling R-HSA-75893 5.592891e-01 0.252 0 0
NRAGE signals death through JNK R-HSA-193648 5.592891e-01 0.252 0 0
Signaling by NTRKs R-HSA-166520 5.605474e-01 0.251 0 0
Antigen processing-Cross presentation R-HSA-1236975 5.629590e-01 0.250 0 0
Circadian clock R-HSA-9909396 5.655342e-01 0.248 0 0
Infectious disease R-HSA-5663205 5.669109e-01 0.246 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 5.720098e-01 0.243 0 0
Attachment and Entry R-HSA-9694614 5.720098e-01 0.243 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 5.720098e-01 0.243 0 0
IRS-mediated signalling R-HSA-112399 5.754763e-01 0.240 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 5.785896e-01 0.238 0 0
Signaling by NOTCH1 R-HSA-1980143 5.790550e-01 0.237 0 0
EGFR downregulation R-HSA-182971 5.823785e-01 0.235 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 5.823785e-01 0.235 0 0
Plus-strand DNA synthesis R-HSA-164525 5.862690e-01 0.232 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.862690e-01 0.232 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.862690e-01 0.232 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.862690e-01 0.232 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.862690e-01 0.232 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 5.862690e-01 0.232 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 5.862690e-01 0.232 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 5.862690e-01 0.232 0 0
PDE3B signalling R-HSA-165160 5.862690e-01 0.232 0 0
Cam-PDE 1 activation R-HSA-111957 5.862690e-01 0.232 0 0
PKB-mediated events R-HSA-109703 5.862690e-01 0.232 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 5.862690e-01 0.232 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.862690e-01 0.232 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 5.862690e-01 0.232 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 5.862690e-01 0.232 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.862690e-01 0.232 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 5.862690e-01 0.232 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.862690e-01 0.232 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 5.901291e-01 0.229 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 5.901291e-01 0.229 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.901291e-01 0.229 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 5.901291e-01 0.229 0 0
Malate-aspartate shuttle R-HSA-9856872 5.901291e-01 0.229 0 0
Non-canonical inflammasome activation R-HSA-9686114 5.901291e-01 0.229 0 0
Signaling by FGFR4 in disease R-HSA-5655291 5.901291e-01 0.229 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 5.954343e-01 0.225 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 5.964658e-01 0.224 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 5.964658e-01 0.224 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 5.964658e-01 0.224 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 5.964658e-01 0.224 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 5.995273e-01 0.222 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 6.031930e-01 0.220 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 6.098008e-01 0.215 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 6.098008e-01 0.215 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 6.116754e-01 0.213 0 0
Regulation of RAS by GAPs R-HSA-5658442 6.161585e-01 0.210 0 0
Signaling by FGFR2 in disease R-HSA-5655253 6.161585e-01 0.210 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.193958e-01 0.208 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.193958e-01 0.208 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 6.193958e-01 0.208 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 6.193958e-01 0.208 0 0
Translesion synthesis by REV1 R-HSA-110312 6.193958e-01 0.208 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.193958e-01 0.208 0 0
p75NTR signals via NF-kB R-HSA-193639 6.193958e-01 0.208 0 0
Spry regulation of FGF signaling R-HSA-1295596 6.193958e-01 0.208 0 0
DNA Damage Reversal R-HSA-73942 6.193958e-01 0.208 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 6.199899e-01 0.208 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 6.199899e-01 0.208 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 6.199899e-01 0.208 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 6.222411e-01 0.206 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 6.222411e-01 0.206 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 6.222411e-01 0.206 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 6.222411e-01 0.206 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 6.222411e-01 0.206 0 0
Regulation of necroptotic cell death R-HSA-5675482 6.233652e-01 0.205 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 6.233652e-01 0.205 0 0
Cardiogenesis R-HSA-9733709 6.233652e-01 0.205 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.294947e-01 0.201 0 0
STAT5 Activation R-HSA-9645135 6.294947e-01 0.201 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.294947e-01 0.201 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.294947e-01 0.201 0 0
Uncoating of the HIV Virion R-HSA-162585 6.294947e-01 0.201 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 6.294947e-01 0.201 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 6.294947e-01 0.201 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 6.294947e-01 0.201 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.294947e-01 0.201 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.294947e-01 0.201 0 0
MET Receptor Activation R-HSA-6806942 6.294947e-01 0.201 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.294947e-01 0.201 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.294947e-01 0.201 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.294947e-01 0.201 0 0
Neurofascin interactions R-HSA-447043 6.294947e-01 0.201 0 0
HDL clearance R-HSA-8964011 6.294947e-01 0.201 0 0
CREB3 factors activate genes R-HSA-8874211 6.294947e-01 0.201 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 6.325725e-01 0.199 0 0
Immune System R-HSA-168256 6.335099e-01 0.198 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 6.336233e-01 0.198 0 0
Formation of paraxial mesoderm R-HSA-9793380 6.371805e-01 0.196 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 6.371805e-01 0.196 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.425620e-01 0.192 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 6.425620e-01 0.192 0 0
Interleukin-6 family signaling R-HSA-6783589 6.425620e-01 0.192 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 6.428754e-01 0.192 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 6.451025e-01 0.190 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 6.451025e-01 0.190 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.470236e-01 0.189 0 0
Translesion synthesis by POLI R-HSA-5656121 6.470236e-01 0.189 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 6.470236e-01 0.189 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.470236e-01 0.189 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.470236e-01 0.189 0 0
Phase 4 - resting membrane potential R-HSA-5576886 6.470236e-01 0.189 0 0
Neurexins and neuroligins R-HSA-6794361 6.482189e-01 0.188 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 6.482189e-01 0.188 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 6.517749e-01 0.186 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 6.617088e-01 0.179 0 0
Calnexin/calreticulin cycle R-HSA-901042 6.617088e-01 0.179 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 6.617088e-01 0.179 0 0
TBC/RABGAPs R-HSA-8854214 6.619809e-01 0.179 0 0
Acyl chain remodelling of PS R-HSA-1482801 6.641706e-01 0.178 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 6.641706e-01 0.178 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 6.660144e-01 0.177 0 0
Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-159782 6.682066e-01 0.175 0 0
Regulation of PTEN localization R-HSA-8948747 6.682066e-01 0.175 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.682066e-01 0.175 0 0
VLDL clearance R-HSA-8964046 6.682066e-01 0.175 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.682066e-01 0.175 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 6.682066e-01 0.175 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.682066e-01 0.175 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.682066e-01 0.175 0 0
PTK6 Expression R-HSA-8849473 6.682066e-01 0.175 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 6.682066e-01 0.175 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.682066e-01 0.175 0 0
Netrin mediated repulsion signals R-HSA-418886 6.682066e-01 0.175 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 6.717620e-01 0.173 0 0
Cytoprotection by HMOX1 R-HSA-9707564 6.719082e-01 0.173 0 0
Translesion synthesis by POLK R-HSA-5655862 6.730355e-01 0.172 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 6.730355e-01 0.172 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 6.730355e-01 0.172 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 6.730355e-01 0.172 0 0
Netrin-1 signaling R-HSA-373752 6.783295e-01 0.169 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 6.785751e-01 0.168 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 6.785751e-01 0.168 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 6.785751e-01 0.168 0 0
Insulin receptor signalling cascade R-HSA-74751 6.798908e-01 0.168 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.806518e-01 0.167 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 6.848123e-01 0.164 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 6.848123e-01 0.164 0 0
Signaling by Insulin receptor R-HSA-74752 6.866898e-01 0.163 0 0
Signaling by NOTCH3 R-HSA-9012852 6.931312e-01 0.159 0 0
Cellular response to hypoxia R-HSA-1234174 6.933975e-01 0.159 0 0
Iron uptake and transport R-HSA-917937 6.944652e-01 0.158 0 0
RUNX2 regulates bone development R-HSA-8941326 6.973102e-01 0.157 0 0
FGFR2 mutant receptor activation R-HSA-1839126 6.973102e-01 0.157 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.974675e-01 0.156 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 6.974675e-01 0.156 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 6.974675e-01 0.156 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.974675e-01 0.156 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.974675e-01 0.156 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.974675e-01 0.156 0 0
Specification of primordial germ cells R-HSA-9827857 6.974675e-01 0.156 0 0
Reverse Transcription of HIV RNA R-HSA-162589 7.028757e-01 0.153 0 0
Minus-strand DNA synthesis R-HSA-164516 7.028757e-01 0.153 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.028757e-01 0.153 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 7.028757e-01 0.153 0 0
phospho-PLA2 pathway R-HSA-111995 7.028757e-01 0.153 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.028757e-01 0.153 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 7.028757e-01 0.153 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.028757e-01 0.153 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 7.028757e-01 0.153 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.028757e-01 0.153 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.028757e-01 0.153 0 0
Regulation by c-FLIP R-HSA-3371378 7.028757e-01 0.153 0 0
Adrenoceptors R-HSA-390696 7.028757e-01 0.153 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 7.028757e-01 0.153 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.028757e-01 0.153 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 7.028757e-01 0.153 0 0
Nucleotide salvage defects R-HSA-9734207 7.028757e-01 0.153 0 0
Dimerization of procaspase-8 R-HSA-69416 7.028757e-01 0.153 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.028757e-01 0.153 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 7.028757e-01 0.153 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.028757e-01 0.153 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 7.044904e-01 0.152 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 7.044904e-01 0.152 0 0
Insulin processing R-HSA-264876 7.044904e-01 0.152 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 7.044904e-01 0.152 0 0
Maturation of hRSV A proteins R-HSA-9828806 7.044904e-01 0.152 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 7.044904e-01 0.152 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 7.094108e-01 0.149 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 7.094108e-01 0.149 0 0
Diseases of DNA repair R-HSA-9675135 7.094108e-01 0.149 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 7.140711e-01 0.146 0 0
Cleavage of the damaged purine R-HSA-110331 7.140711e-01 0.146 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 7.203657e-01 0.142 0 0
Mismatch Repair R-HSA-5358508 7.203657e-01 0.142 0 0
PKA activation in glucagon signalling R-HSA-164378 7.203657e-01 0.142 0 0
Apoptotic factor-mediated response R-HSA-111471 7.203657e-01 0.142 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 7.203657e-01 0.142 0 0
Synthesis of PA R-HSA-1483166 7.208679e-01 0.142 0 0
Insulin receptor recycling R-HSA-77387 7.232142e-01 0.141 0 0
Inflammasomes R-HSA-622312 7.232142e-01 0.141 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 7.241368e-01 0.140 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 7.301402e-01 0.137 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 7.301402e-01 0.137 0 0
Elastic fibre formation R-HSA-1566948 7.301402e-01 0.137 0 0
Depurination R-HSA-73927 7.301402e-01 0.137 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 7.301402e-01 0.137 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 7.339240e-01 0.134 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.339240e-01 0.134 0 0
CASP8 activity is inhibited R-HSA-5218900 7.339240e-01 0.134 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.339240e-01 0.134 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.339240e-01 0.134 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.339240e-01 0.134 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.339240e-01 0.134 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.339240e-01 0.134 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.339240e-01 0.134 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.339240e-01 0.134 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.339240e-01 0.134 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.339240e-01 0.134 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 7.339240e-01 0.134 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 7.340642e-01 0.134 0 0
Co-stimulation by CD28 R-HSA-389356 7.383190e-01 0.132 0 0
Signaling by Erythropoietin R-HSA-9006335 7.409983e-01 0.130 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 7.409983e-01 0.130 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 7.417838e-01 0.130 0 0
E2F mediated regulation of DNA replication R-HSA-113510 7.417838e-01 0.130 0 0
Germ layer formation at gastrulation R-HSA-9754189 7.417838e-01 0.130 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 7.417838e-01 0.130 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 7.417838e-01 0.130 0 0
Regulation of signaling by CBL R-HSA-912631 7.417838e-01 0.130 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.418005e-01 0.130 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 7.424580e-01 0.129 0 0
Cardiac conduction R-HSA-5576891 7.435993e-01 0.129 0 0
Plasma lipoprotein clearance R-HSA-8964043 7.455226e-01 0.128 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 7.519598e-01 0.124 0 0
DAP12 signaling R-HSA-2424491 7.578612e-01 0.120 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 7.578612e-01 0.120 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.578612e-01 0.120 0 0
tRNA Aminoacylation R-HSA-379724 7.591115e-01 0.120 0 0
Metabolism of polyamines R-HSA-351202 7.591115e-01 0.120 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 7.602263e-01 0.119 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.602263e-01 0.119 0 0
Diseases of Immune System R-HSA-5260271 7.602263e-01 0.119 0 0
Signaling by FGFR R-HSA-190236 7.603824e-01 0.119 0 0
Base Excision Repair R-HSA-73884 7.615336e-01 0.118 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 7.617296e-01 0.118 0 0
MAPK3 (ERK1) activation R-HSA-110056 7.617296e-01 0.118 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.617296e-01 0.118 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 7.617296e-01 0.118 0 0
Pexophagy R-HSA-9664873 7.617296e-01 0.118 0 0
CASP4 inflammasome assembly R-HSA-9948001 7.617296e-01 0.118 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 7.617296e-01 0.118 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.617296e-01 0.118 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.617296e-01 0.118 0 0
Maturation of spike protein R-HSA-9683686 7.617296e-01 0.118 0 0
Formation of apoptosome R-HSA-111458 7.617296e-01 0.118 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.617810e-01 0.118 0 0
Co-inhibition by CTLA4 R-HSA-389513 7.617810e-01 0.118 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.634695e-01 0.117 0 0
tRNA processing R-HSA-72306 7.644484e-01 0.117 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 7.738252e-01 0.111 0 0
Budding and maturation of HIV virion R-HSA-162588 7.738252e-01 0.111 0 0
Molecules associated with elastic fibres R-HSA-2129379 7.738252e-01 0.111 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 7.742615e-01 0.111 0 0
FLT3 Signaling R-HSA-9607240 7.742615e-01 0.111 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 7.742615e-01 0.111 0 0
Rab regulation of trafficking R-HSA-9007101 7.770030e-01 0.110 0 0
Protein localization R-HSA-9609507 7.773180e-01 0.109 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 7.804204e-01 0.108 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.804204e-01 0.108 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.804204e-01 0.108 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.804204e-01 0.108 0 0
Mitochondrial protein import R-HSA-1268020 7.823800e-01 0.107 0 0
Neddylation R-HSA-8951664 7.841183e-01 0.106 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.866309e-01 0.104 0 0
Signaling by APC mutants R-HSA-4839744 7.866309e-01 0.104 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 7.866309e-01 0.104 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 7.866309e-01 0.104 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 7.866309e-01 0.104 0 0
Ionotropic activity of kainate receptors R-HSA-451306 7.866309e-01 0.104 0 0
vRNA Synthesis R-HSA-192814 7.866309e-01 0.104 0 0
Synthesis of PI R-HSA-1483226 7.866309e-01 0.104 0 0
Transport of RCbl within the body R-HSA-9758890 7.866309e-01 0.104 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 7.866309e-01 0.104 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.866309e-01 0.104 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 7.876409e-01 0.104 0 0
HIV Transcription Initiation R-HSA-167161 7.876409e-01 0.104 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 7.876409e-01 0.104 0 0
Intra-Golgi traffic R-HSA-6811438 7.876409e-01 0.104 0 0
Scavenging by Class A Receptors R-HSA-3000480 7.876409e-01 0.104 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.896831e-01 0.103 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 7.924172e-01 0.101 0 0
Signaling by PTK6 R-HSA-8848021 7.933576e-01 0.101 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 7.933576e-01 0.101 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.933981e-01 0.101 0 0
Assembly Of The HIV Virion R-HSA-175474 7.977673e-01 0.098 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.003786e-01 0.097 0 0
Depyrimidination R-HSA-73928 8.003786e-01 0.097 0 0
G-protein beta:gamma signalling R-HSA-397795 8.031593e-01 0.095 0 0
Ion transport by P-type ATPases R-HSA-936837 8.039050e-01 0.095 0 0
DS-GAG biosynthesis R-HSA-2022923 8.089311e-01 0.092 0 0
Scavenging by Class H Receptors R-HSA-3000497 8.089311e-01 0.092 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.089311e-01 0.092 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 8.089311e-01 0.092 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 8.089311e-01 0.092 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 8.089311e-01 0.092 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 8.089311e-01 0.092 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.089311e-01 0.092 0 0
Plasmalogen biosynthesis R-HSA-75896 8.089311e-01 0.092 0 0
Signaling by AXIN mutants R-HSA-4839735 8.089311e-01 0.092 0 0
Signaling by AMER1 mutants R-HSA-4839748 8.089311e-01 0.092 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.089311e-01 0.092 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.089311e-01 0.092 0 0
Activation of RAC1 R-HSA-428540 8.089311e-01 0.092 0 0
Sodium/Calcium exchangers R-HSA-425561 8.089311e-01 0.092 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 8.122428e-01 0.090 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.124906e-01 0.090 0 0
Signaling by FGFR4 R-HSA-5654743 8.124906e-01 0.090 0 0
Response of Mtb to phagocytosis R-HSA-9637690 8.124906e-01 0.090 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.138883e-01 0.089 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 8.138883e-01 0.089 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 8.138883e-01 0.089 0 0
LDL clearance R-HSA-8964038 8.138883e-01 0.089 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 8.138883e-01 0.089 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.163952e-01 0.088 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.165860e-01 0.088 0 0
Disorders of transmembrane transporters R-HSA-5619115 8.200619e-01 0.086 0 0
Adipogenesis R-HSA-9843745 8.217767e-01 0.085 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.259625e-01 0.083 0 0
Interleukin-20 family signaling R-HSA-8854691 8.288499e-01 0.082 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 8.288499e-01 0.082 0 0
MET activates RAS signaling R-HSA-8851805 8.289018e-01 0.081 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 8.289018e-01 0.081 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 8.289018e-01 0.081 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 8.289018e-01 0.081 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.289018e-01 0.081 0 0
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-HSA-159854 8.289018e-01 0.081 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.289018e-01 0.081 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.289018e-01 0.081 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.289018e-01 0.081 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.289018e-01 0.081 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 8.289018e-01 0.081 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 8.292262e-01 0.081 0 0
eNOS activation R-HSA-203615 8.292262e-01 0.081 0 0
Mitophagy R-HSA-5205647 8.292262e-01 0.081 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.292262e-01 0.081 0 0
SLC-mediated transport of amino acids R-HSA-9958863 8.330387e-01 0.079 0 0
Integrin cell surface interactions R-HSA-216083 8.346132e-01 0.079 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.349067e-01 0.078 0 0
Signaling by FGFR3 R-HSA-5654741 8.349067e-01 0.078 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.362798e-01 0.078 0 0
Oncogene Induced Senescence R-HSA-2559585 8.411114e-01 0.075 0 0
Transferrin endocytosis and recycling R-HSA-917977 8.411114e-01 0.075 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 8.427184e-01 0.074 0 0
Complex III assembly R-HSA-9865881 8.427184e-01 0.074 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 8.427184e-01 0.074 0 0
Mitochondrial RNA degradation R-HSA-9836573 8.427184e-01 0.074 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.427184e-01 0.074 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.467861e-01 0.072 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 8.467861e-01 0.072 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.467861e-01 0.072 0 0
Diseases of nucleotide metabolism R-HSA-9735804 8.467861e-01 0.072 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.467861e-01 0.072 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 8.467861e-01 0.072 0 0
Neuronal System R-HSA-112316 8.484321e-01 0.071 0 0
Selenoamino acid metabolism R-HSA-2408522 8.486719e-01 0.071 0 0
Stimuli-sensing channels R-HSA-2672351 8.501143e-01 0.071 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.515278e-01 0.070 0 0
Triglyceride catabolism R-HSA-163560 8.522735e-01 0.069 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 8.550373e-01 0.068 0 0
Synthesis of PC R-HSA-1483191 8.550373e-01 0.068 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.555588e-01 0.068 0 0
Tight junction interactions R-HSA-420029 8.555588e-01 0.068 0 0
Laminin interactions R-HSA-3000157 8.555588e-01 0.068 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.555588e-01 0.068 0 0
Hyaluronan degradation R-HSA-2160916 8.555588e-01 0.068 0 0
Peroxisomal protein import R-HSA-9033241 8.602072e-01 0.065 0 0
Amino acid transport across the plasma membrane R-HSA-352230 8.602072e-01 0.065 0 0
Triglyceride metabolism R-HSA-8979227 8.602072e-01 0.065 0 0
Removal of the Flap Intermediate R-HSA-69166 8.628021e-01 0.064 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.628021e-01 0.064 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.628021e-01 0.064 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 8.628021e-01 0.064 0 0
Hydrolysis of LPC R-HSA-1483115 8.628021e-01 0.064 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 8.628021e-01 0.064 0 0
CRMPs in Sema3A signaling R-HSA-399956 8.628021e-01 0.064 0 0
Physiological factors R-HSA-5578768 8.628021e-01 0.064 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.628021e-01 0.064 0 0
HDL assembly R-HSA-8963896 8.628021e-01 0.064 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.628021e-01 0.064 0 0
Zinc transporters R-HSA-435354 8.628021e-01 0.064 0 0
GPER1 signaling R-HSA-9634597 8.642948e-01 0.063 0 0
NGF-stimulated transcription R-HSA-9031628 8.642948e-01 0.063 0 0
Plasma lipoprotein remodeling R-HSA-8963899 8.642948e-01 0.063 0 0
HCMV Late Events R-HSA-9610379 8.664597e-01 0.062 0 0
Sphingolipid catabolism R-HSA-9845614 8.674345e-01 0.062 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.684573e-01 0.061 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 8.728464e-01 0.059 0 0
Ion channel transport R-HSA-983712 8.763741e-01 0.057 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.771446e-01 0.057 0 0
Erythropoietin activates RAS R-HSA-9027284 8.771446e-01 0.057 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 8.771446e-01 0.057 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 8.771446e-01 0.057 0 0
Protein lipoylation R-HSA-9857492 8.771446e-01 0.057 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.771446e-01 0.057 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.771446e-01 0.057 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.771446e-01 0.057 0 0
p38MAPK events R-HSA-171007 8.771446e-01 0.057 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.771446e-01 0.057 0 0
Other semaphorin interactions R-HSA-416700 8.771446e-01 0.057 0 0
Triglyceride biosynthesis R-HSA-75109 8.784067e-01 0.056 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.784067e-01 0.056 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.784067e-01 0.056 0 0
Azathioprine ADME R-HSA-9748787 8.812954e-01 0.055 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 8.817446e-01 0.055 0 0
Mitochondrial protein degradation R-HSA-9837999 8.854429e-01 0.053 0 0
Protein-protein interactions at synapses R-HSA-6794362 8.859463e-01 0.053 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.885345e-01 0.051 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 8.885345e-01 0.051 0 0
Asparagine N-linked glycosylation R-HSA-446203 8.897478e-01 0.051 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.899886e-01 0.051 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.899886e-01 0.051 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 8.899886e-01 0.051 0 0
Killing mechanisms R-HSA-9664420 8.899886e-01 0.051 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.899886e-01 0.051 0 0
Regulation of BACH1 activity R-HSA-9708530 8.899886e-01 0.051 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 8.899886e-01 0.051 0 0
Fructose catabolism R-HSA-70350 8.899886e-01 0.051 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 8.899886e-01 0.051 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.899886e-01 0.051 0 0
Differentiation of T cells R-HSA-9945266 8.899886e-01 0.051 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.899886e-01 0.051 0 0
Negative regulation of FLT3 R-HSA-9706369 8.899886e-01 0.051 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 8.899886e-01 0.051 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 8.899886e-01 0.051 0 0
Attachment and Entry R-HSA-9678110 8.899886e-01 0.051 0 0
Virus Assembly and Release R-HSA-168268 8.899886e-01 0.051 0 0
Generation of second messenger molecules R-HSA-202433 8.903365e-01 0.050 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 8.920604e-01 0.050 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 8.966136e-01 0.047 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.978746e-01 0.047 0 0
Regulation of gene expression in beta cells R-HSA-210745 8.978746e-01 0.047 0 0
Platelet calcium homeostasis R-HSA-418360 8.978746e-01 0.047 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.978746e-01 0.047 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 8.978746e-01 0.047 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 8.983646e-01 0.047 0 0
Maturation of spike protein R-HSA-9694548 8.983646e-01 0.047 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.014904e-01 0.045 0 0
Glycine degradation R-HSA-6783984 9.014904e-01 0.045 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 9.014904e-01 0.045 0 0
Scavenging by Class B Receptors R-HSA-3000471 9.014904e-01 0.045 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 9.014904e-01 0.045 0 0
Fibronectin matrix formation R-HSA-1566977 9.014904e-01 0.045 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 9.014904e-01 0.045 0 0
Heme assimilation R-HSA-9927020 9.014904e-01 0.045 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 9.014904e-01 0.045 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 9.014904e-01 0.045 0 0
Passive transport by Aquaporins R-HSA-432047 9.014904e-01 0.045 0 0
Galactose catabolism R-HSA-70370 9.014904e-01 0.045 0 0
Coenzyme A biosynthesis R-HSA-196783 9.014904e-01 0.045 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.014904e-01 0.045 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.014904e-01 0.045 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.014904e-01 0.045 0 0
Interferon alpha/beta signaling R-HSA-909733 9.018521e-01 0.045 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.033169e-01 0.044 0 0
Translation of Structural Proteins R-HSA-9694635 9.058308e-01 0.043 0 0
Translation of Structural Proteins R-HSA-9683701 9.058593e-01 0.043 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 9.064808e-01 0.043 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 9.064808e-01 0.043 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.064808e-01 0.043 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.064808e-01 0.043 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.064808e-01 0.043 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.098102e-01 0.041 0 0
SLC transporter disorders R-HSA-5619102 9.111105e-01 0.040 0 0
G alpha (12/13) signalling events R-HSA-416482 9.113248e-01 0.040 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 9.117904e-01 0.040 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 9.117904e-01 0.040 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.117904e-01 0.040 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.128500e-01 0.040 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 9.144045e-01 0.039 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.158086e-01 0.038 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.173357e-01 0.037 0 0
MyD88-independent TLR4 cascade R-HSA-166166 9.201057e-01 0.036 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 9.201057e-01 0.036 0 0
Regulated Necrosis R-HSA-5218859 9.207372e-01 0.036 0 0
Interferon gamma signaling R-HSA-877300 9.209076e-01 0.036 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.210139e-01 0.036 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.210139e-01 0.036 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 9.210139e-01 0.036 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.210139e-01 0.036 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.210139e-01 0.036 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.210139e-01 0.036 0 0
Signaling by FGFR1 R-HSA-5654736 9.216434e-01 0.035 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.216434e-01 0.035 0 0
Signaling by WNT in cancer R-HSA-4791275 9.216943e-01 0.035 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.216943e-01 0.035 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.232033e-01 0.035 0 0
DAP12 interactions R-HSA-2172127 9.254325e-01 0.034 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 9.283961e-01 0.032 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.292735e-01 0.032 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.292735e-01 0.032 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.292735e-01 0.032 0 0
Diseases of hemostasis R-HSA-9671793 9.292735e-01 0.032 0 0
HDL remodeling R-HSA-8964058 9.292735e-01 0.032 0 0
PI Metabolism R-HSA-1483255 9.295385e-01 0.032 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.310784e-01 0.031 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.316862e-01 0.031 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.316862e-01 0.031 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.318830e-01 0.031 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.336531e-01 0.030 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.345531e-01 0.029 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.345531e-01 0.029 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.345531e-01 0.029 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.345531e-01 0.029 0 0
Heme degradation R-HSA-189483 9.345531e-01 0.029 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.363282e-01 0.029 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.366698e-01 0.028 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 9.366698e-01 0.028 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.366698e-01 0.028 0 0
Creatine metabolism R-HSA-71288 9.366698e-01 0.028 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.366698e-01 0.028 0 0
Pregnenolone biosynthesis R-HSA-196108 9.366698e-01 0.028 0 0
Signaling by NODAL R-HSA-1181150 9.366698e-01 0.028 0 0
Glycogen synthesis R-HSA-3322077 9.366698e-01 0.028 0 0
Extracellular matrix organization R-HSA-1474244 9.375422e-01 0.028 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.392162e-01 0.027 0 0
Signaling by NOTCH2 R-HSA-1980145 9.402059e-01 0.027 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 9.402059e-01 0.027 0 0
Hyaluronan metabolism R-HSA-2142845 9.402059e-01 0.027 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.402059e-01 0.027 0 0
Signal amplification R-HSA-392518 9.402059e-01 0.027 0 0
RAB geranylgeranylation R-HSA-8873719 9.412132e-01 0.026 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 9.421249e-01 0.026 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.432930e-01 0.025 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.432930e-01 0.025 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.432930e-01 0.025 0 0
Signalling to RAS R-HSA-167044 9.432930e-01 0.025 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.432930e-01 0.025 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.432930e-01 0.025 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.432930e-01 0.025 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.432930e-01 0.025 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.453926e-01 0.024 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.453926e-01 0.024 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.453926e-01 0.024 0 0
CS-GAG biosynthesis R-HSA-2022870 9.492239e-01 0.023 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.492239e-01 0.023 0 0
Androgen biosynthesis R-HSA-193048 9.492239e-01 0.023 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.492239e-01 0.023 0 0
Ribavirin ADME R-HSA-9755088 9.492239e-01 0.023 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.492255e-01 0.023 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.494369e-01 0.023 0 0
Disease R-HSA-1643685 9.499066e-01 0.022 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.499394e-01 0.022 0 0
Glycosphingolipid transport R-HSA-9845576 9.501489e-01 0.022 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.501489e-01 0.022 0 0
Fructose metabolism R-HSA-5652084 9.545348e-01 0.020 0 0
Ethanol oxidation R-HSA-71384 9.545348e-01 0.020 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.562239e-01 0.019 0 0
The phototransduction cascade R-HSA-2514856 9.574502e-01 0.019 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.585010e-01 0.018 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.592905e-01 0.018 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.592905e-01 0.018 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.592905e-01 0.018 0 0
Formation of the ureteric bud R-HSA-9830674 9.592905e-01 0.018 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.592905e-01 0.018 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.605504e-01 0.017 0 0
Neurotransmitter release cycle R-HSA-112310 9.610431e-01 0.017 0 0
RAS processing R-HSA-9648002 9.621567e-01 0.017 0 0
Pentose phosphate pathway R-HSA-71336 9.621567e-01 0.017 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.623220e-01 0.017 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.635490e-01 0.016 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.635490e-01 0.016 0 0
Nucleotide biosynthesis R-HSA-8956320 9.638943e-01 0.016 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 9.649668e-01 0.015 0 0
Glycogen metabolism R-HSA-8982491 9.655020e-01 0.015 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.655020e-01 0.015 0 0
Formation of the nephric duct R-HSA-9830364 9.673622e-01 0.014 0 0
G alpha (z) signalling events R-HSA-418597 9.694108e-01 0.013 0 0
Urea cycle R-HSA-70635 9.707768e-01 0.013 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.707768e-01 0.013 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.707768e-01 0.013 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.713592e-01 0.013 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.713592e-01 0.013 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.722226e-01 0.012 0 0
Integration of energy metabolism R-HSA-163685 9.726602e-01 0.012 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.728392e-01 0.012 0 0
Signaling by BMP R-HSA-201451 9.738343e-01 0.012 1 1
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.738343e-01 0.012 0 0
Synthesis of PE R-HSA-1483213 9.738343e-01 0.012 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.742856e-01 0.011 0 0
ECM proteoglycans R-HSA-3000178 9.742856e-01 0.011 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 9.762041e-01 0.010 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.765720e-01 0.010 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.765720e-01 0.010 0 0
Iron assimilation using enterobactin R-HSA-9638334 9.765720e-01 0.010 0 0
Pyroptosis R-HSA-5620971 9.765720e-01 0.010 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.772941e-01 0.010 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 9.778131e-01 0.010 0 0
Amine ligand-binding receptors R-HSA-375280 9.783830e-01 0.009 0 0
Thyroxine biosynthesis R-HSA-209968 9.790235e-01 0.009 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 9.790235e-01 0.009 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.790235e-01 0.009 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 9.792277e-01 0.009 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 9.802309e-01 0.009 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 9.802309e-01 0.009 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 9.802309e-01 0.009 0 0
Regulation of insulin secretion R-HSA-422356 9.802309e-01 0.009 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.803293e-01 0.009 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.803293e-01 0.009 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.811828e-01 0.008 0 0
Aquaporin-mediated transport R-HSA-445717 9.815594e-01 0.008 0 0
MAP kinase activation R-HSA-450294 9.815594e-01 0.008 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.821050e-01 0.008 0 0
Cargo concentration in the ER R-HSA-5694530 9.831840e-01 0.007 0 0
Toll-like Receptor Cascades R-HSA-168898 9.843727e-01 0.007 0 0
HS-GAG degradation R-HSA-2024096 9.849439e-01 0.007 0 0
DAG1 glycosylations R-HSA-8931838 9.849439e-01 0.007 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.851999e-01 0.006 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.865197e-01 0.006 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.865197e-01 0.006 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 9.873356e-01 0.006 0 0
CS/DS degradation R-HSA-2024101 9.879307e-01 0.005 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.883600e-01 0.005 0 0
RA biosynthesis pathway R-HSA-5365859 9.891940e-01 0.005 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.891940e-01 0.005 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.891940e-01 0.005 0 0
NOD1/2 Signaling Pathway R-HSA-168638 9.891940e-01 0.005 0 0
Collagen formation R-HSA-1474290 9.892119e-01 0.005 0 0
Platelet homeostasis R-HSA-418346 9.895679e-01 0.005 0 0
Leishmania phagocytosis R-HSA-9664417 9.897582e-01 0.004 0 0
Parasite infection R-HSA-9664407 9.897582e-01 0.004 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.897582e-01 0.004 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.899303e-01 0.004 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 9.908045e-01 0.004 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 9.908045e-01 0.004 0 0
HS-GAG biosynthesis R-HSA-2022928 9.913380e-01 0.004 0 0
Interleukin-17 signaling R-HSA-448424 9.915505e-01 0.004 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.915505e-01 0.004 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.919232e-01 0.004 0 0
Phospholipid metabolism R-HSA-1483257 9.920044e-01 0.003 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.922449e-01 0.003 0 0
Voltage gated Potassium channels R-HSA-1296072 9.922449e-01 0.003 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.922449e-01 0.003 0 0
Metabolism of folate and pterines R-HSA-196757 9.922449e-01 0.003 0 0
Retinoid metabolism and transport R-HSA-975634 9.922631e-01 0.003 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 9.925483e-01 0.003 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 9.925483e-01 0.003 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.930568e-01 0.003 0 0
Purine salvage R-HSA-74217 9.930568e-01 0.003 0 0
Pyruvate metabolism R-HSA-70268 9.934173e-01 0.003 0 0
Formation of the cornified envelope R-HSA-6809371 9.935318e-01 0.003 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.937838e-01 0.003 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.940693e-01 0.003 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.944347e-01 0.002 0 0
Tryptophan catabolism R-HSA-71240 9.944347e-01 0.002 0 0
Regulation of beta-cell development R-HSA-186712 9.948779e-01 0.002 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.948779e-01 0.002 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.953744e-01 0.002 0 0
Collagen degradation R-HSA-1442490 9.957872e-01 0.002 0 0
Interleukin-10 signaling R-HSA-6783783 9.958532e-01 0.002 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.960065e-01 0.002 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.964247e-01 0.002 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.967992e-01 0.001 0 0
Surfactant metabolism R-HSA-5683826 9.967992e-01 0.001 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.968367e-01 0.001 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.969588e-01 0.001 0 0
Parasitic Infection Pathways R-HSA-9824443 9.972558e-01 0.001 0 0
Leishmania infection R-HSA-9658195 9.972558e-01 0.001 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.973882e-01 0.001 0 0
Kidney development R-HSA-9830369 9.976654e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.976654e-01 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 9.978853e-01 0.001 0 0
Innate Immune System R-HSA-168249 9.978950e-01 0.001 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.980210e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.981594e-01 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.983523e-01 0.001 0 0
Metal ion assimilation from the host R-HSA-9638482 9.984297e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.984297e-01 0.001 0 0
Metabolism of porphyrins R-HSA-189445 9.984297e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.985249e-01 0.001 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.985249e-01 0.001 0 0
Peptide hormone metabolism R-HSA-2980736 9.987453e-01 0.001 0 0
RSV-host interactions R-HSA-9833110 9.987985e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.989413e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.990527e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.991520e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.992195e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.992409e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.993917e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.993917e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.993989e-01 0.000 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.994555e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.995126e-01 0.000 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.996010e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.996094e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.996504e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.996652e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.997340e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.997470e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.997493e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.997767e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.997779e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.998559e-01 0.000 0 0
PPARA activates gene expression R-HSA-1989781 9.998635e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.998694e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.998710e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.998710e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.998712e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.998803e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.998967e-01 0.000 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.999259e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.999259e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.999261e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.999337e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999473e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999547e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999590e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999611e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999619e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999653e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999660e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999731e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999731e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999778e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.999839e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999888e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999919e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999928e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999942e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999942e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999948e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999962e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999973e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999973e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999976e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999985e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999986e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999988e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999991e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999994e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999994e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999998e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999998e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999999e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999999e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999999e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999999e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways