GRK3

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
O95394 S64 Sugiyama PGM3 AGM1 LLAVLRSKQTKSTIGVMVtAsHNPEEDNGVKLVDPLGEMLA
P07550 S355 ELM|EPSD|PSP ADRB2 ADRB2R B2AR AFQELLCLRRssLKAyGNGyssNGNtGEQsGYHVEQEKENK
P07550 S356 ELM|EPSD|PSP ADRB2 ADRB2R B2AR FQELLCLRRssLKAyGNGyssNGNtGEQsGYHVEQEKENKL
P08172 S232 ELM CHRM2 ASKSRIKKDKKEPVANQDPVsPsLVQGRIVKPNNNNMPssD
P08172 S234 ELM CHRM2 KSRIKKDKKEPVANQDPVsPsLVQGRIVKPNNNNMPssDDG
P08172 S250 ELM CHRM2 PVsPsLVQGRIVKPNNNNMPssDDGLEHNKIQNGKAPRDPV
P08172 S251 ELM CHRM2 VsPsLVQGRIVKPNNNNMPssDDGLEHNKIQNGKAPRDPVt
P08172 S282 ELM CHRM2 NGKAPRDPVtENCVQGEEKEssNDstsVsAVAsNMRDDEIt
P08172 S283 ELM CHRM2 GKAPRDPVtENCVQGEEKEssNDstsVsAVAsNMRDDEItQ
P08172 S286 ELM CHRM2 PRDPVtENCVQGEEKEssNDstsVsAVAsNMRDDEItQDEN
P08172 S288 ELM CHRM2 DPVtENCVQGEEKEssNDstsVsAVAsNMRDDEItQDENtV
P08172 S290 ELM CHRM2 VtENCVQGEEKEssNDstsVsAVAsNMRDDEItQDENtVst
P08172 S294 ELM CHRM2 CVQGEEKEssNDstsVsAVAsNMRDDEItQDENtVstsLGH
P08172 S309 ELM CHRM2 VsAVAsNMRDDEItQDENtVstsLGHSKDENSKQTCIRIGT
P08172 S311 ELM CHRM2 AVAsNMRDDEItQDENtVstsLGHSKDENSKQTCIRIGTKT
P08172 T271 ELM CHRM2 sDDGLEHNKIQNGKAPRDPVtENCVQGEEKEssNDstsVsA
P08172 T287 ELM CHRM2 RDPVtENCVQGEEKEssNDstsVsAVAsNMRDDEItQDENt
P08172 T302 ELM CHRM2 ssNDstsVsAVAsNMRDDEItQDENtVstsLGHSKDENSKQ
P08172 T307 ELM CHRM2 tsVsAVAsNMRDDEItQDENtVstsLGHSKDENSKQTCIRI
P08172 T310 ELM CHRM2 sAVAsNMRDDEItQDENtVstsLGHSKDENSKQTCIRIGTK
P21731 S239 SIGNOR|PSP TBXA2R VATLCHVYHGQEAAQQRPRDsEVEMMAQLLGIMVVASVCWL
P30411 S366 SIGNOR BDKRB2 BKR2 VyQGVCQKGGCRSEPIQMENsMGTLRTsIsVERQIHKLQDW
P30411 S373 SIGNOR BDKRB2 BKR2 KGGCRSEPIQMENsMGTLRTsIsVERQIHKLQDWAGSRQ__
P30411 S375 SIGNOR BDKRB2 BKR2 GCRSEPIQMENsMGTLRTsIsVERQIHKLQDWAGSRQ____
P30874 S341 EPSD|PSP SSTR2 KSFQNVLCLVKVSGTDDGERsDsKQDKSRLNEttEtQRtLL
P30874 S343 EPSD|PSP SSTR2 FQNVLCLVKVSGTDDGERsDsKQDKSRLNEttEtQRtLLNG
P32245 S329 ELM MC4R LRKtFKEIICCYPLGGLCDLssRY_________________
P32245 S330 ELM MC4R RKtFKEIICCYPLGGLCDLssRY__________________
P32245 T312 ELM MC4R MCNSIIDPLIYALRSQELRKtFKEIICCYPLGGLCDLssRY
P35372 T182 SIGNOR OPRM1 MOR1 TMSVDRyIAVCHPVKALDFRtPRNAKIINVCNWILSSAIGL
P41143 S363 PSP OPRD1 OPRD SsFSRAREATARERVtACtPsDGPGGGAAA___________
P41143 T361 PSP OPRD1 OPRD DPSsFSRAREATARERVtACtPsDGPGGGAAA_________
P41146 S346 PSP OPRL1 OOR ORL1 FKACFRKFCCASALRRDVQVsDRVRsIAKDVALACKtsETV
P41146 S351 PSP OPRL1 OOR ORL1 RKFCCASALRRDVQVsDRVRsIAKDVALACKtsETVPRPA_
P41146 S363 EPSD|PSP OPRL1 OOR ORL1 VQVsDRVRsIAKDVALACKtsETVPRPA_____________
P41146 T362 PSP OPRL1 OOR ORL1 DVQVsDRVRsIAKDVALACKtsETVPRPA____________
P51681 S336 GPS6|SIGNOR|ELM|EPSD|PSP CCR5 CMKBR5 IAKRFCKCCSIFQQEAPERAssVyTRsTGEQEIsVGL____
P51681 S337 GPS6|SIGNOR|ELM|EPSD|PSP CCR5 CMKBR5 AKRFCKCCSIFQQEAPERAssVyTRsTGEQEIsVGL_____
P51681 S342 GPS6|SIGNOR|ELM|EPSD|PSP CCR5 CMKBR5 KCCSIFQQEAPERAssVyTRsTGEQEIsVGL__________
P51681 S349 GPS6|SIGNOR|ELM|EPSD|PSP CCR5 CMKBR5 QEAPERAssVyTRsTGEQEIsVGL_________________
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68363 T73 Sugiyama TUBA1B FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q08J23 S593 Sugiyama NSUN2 SAKI TRM4 NNSEKMKVINTGIKVWCRNNsGEEFDCAFRLAQEGIYTLYP
Q6ZMQ8 T784 Sugiyama AATK AATYK KIAA0641 LMR1 LMTK1 SWTETASSGGDHPQAEPKLAtEAEGTTGPRLPLPSVPSPSQ
Q71U36 T73 Sugiyama TUBA1A TUBA3 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3 T73 Sugiyama TUBA1C TUBA6 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 2.425247e-09 8.615 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 9.765033e-09 8.010 0 0
M Phase R-HSA-68886 6.285416e-08 7.202 0 0
Cell Cycle, Mitotic R-HSA-69278 5.753211e-08 7.240 0 0
Signal Transduction R-HSA-162582 3.872591e-07 6.412 1 0
Mitotic Prophase R-HSA-68875 4.893482e-07 6.310 0 0
Apoptotic execution phase R-HSA-75153 4.726115e-07 6.325 0 0
Cell-Cell communication R-HSA-1500931 1.129336e-06 5.947 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.444643e-06 5.840 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.090350e-06 5.680 0 0
Meiotic synapsis R-HSA-1221632 2.917522e-06 5.535 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 4.813037e-06 5.318 0 0
Chromatin organization R-HSA-4839726 4.780648e-06 5.321 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 9.107529e-06 5.041 0 0
Cell junction organization R-HSA-446728 8.930560e-06 5.049 0 0
Cellular response to heat stress R-HSA-3371556 1.074884e-05 4.969 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.160302e-05 4.935 0 0
Mitotic Prometaphase R-HSA-68877 1.175208e-05 4.930 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.855773e-05 4.731 0 0
Chromatin modifying enzymes R-HSA-3247509 2.006521e-05 4.698 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 3.724734e-05 4.429 0 0
Gene Silencing by RNA R-HSA-211000 4.698486e-05 4.328 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 5.135146e-05 4.289 0 0
G2/M DNA damage checkpoint R-HSA-69473 6.144237e-05 4.212 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 6.502038e-05 4.187 0 0
Signaling by EGFR R-HSA-177929 6.375365e-05 4.195 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 7.174872e-05 4.144 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 8.079290e-05 4.093 0 0
L1CAM interactions R-HSA-373760 8.220156e-05 4.085 0 0
Cell Cycle Checkpoints R-HSA-69620 8.596254e-05 4.066 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.075606e-04 3.968 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.047418e-04 3.980 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.099316e-04 3.959 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.158290e-04 3.936 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.244485e-04 3.905 0 0
Meiosis R-HSA-1500620 1.276526e-04 3.894 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.383803e-04 3.859 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.383803e-04 3.859 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.461653e-04 3.835 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.545814e-04 3.811 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.779313e-04 3.750 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.252917e-04 3.647 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.291267e-04 3.640 0 0
Deubiquitination R-HSA-5688426 2.377358e-04 3.624 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.923504e-04 3.534 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.923504e-04 3.534 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.763985e-04 3.558 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.911643e-04 3.536 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 2.943490e-04 3.531 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.879819e-04 3.541 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.106669e-04 3.508 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.290626e-04 3.483 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.272400e-04 3.485 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.105671e-04 3.508 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.316050e-04 3.479 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.391573e-04 3.470 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.514306e-04 3.454 0 0
G2/M Checkpoints R-HSA-69481 3.363057e-04 3.473 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.590311e-04 3.445 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 3.932623e-04 3.405 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 4.512004e-04 3.346 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 4.638913e-04 3.334 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 4.638913e-04 3.334 0 0
HDACs deacetylate histones R-HSA-3214815 4.780560e-04 3.321 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 4.925612e-04 3.308 0 0
HATs acetylate histones R-HSA-3214847 5.049485e-04 3.297 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 5.312339e-04 3.275 0 0
Adherens junctions interactions R-HSA-418990 5.344631e-04 3.272 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 5.386669e-04 3.269 0 0
Homology Directed Repair R-HSA-5693538 5.452201e-04 3.263 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 5.774072e-04 3.239 0 0
Ub-specific processing proteases R-HSA-5689880 5.641627e-04 3.249 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 5.774072e-04 3.239 0 0
Cell-cell junction organization R-HSA-421270 5.839188e-04 3.234 0 0
Axon guidance R-HSA-422475 5.907669e-04 3.229 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 6.018439e-04 3.221 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 6.815103e-04 3.167 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 7.099054e-04 3.149 0 0
Nuclear import of Rev protein R-HSA-180746 7.133762e-04 3.147 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 7.205494e-04 3.142 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 7.309115e-04 3.136 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 7.507240e-04 3.125 0 0
Negative regulation of MET activity R-HSA-6807004 7.888667e-04 3.103 0 0
Nervous system development R-HSA-9675108 9.811588e-04 3.008 0 0
Cellular Senescence R-HSA-2559583 1.023536e-03 2.990 0 0
Signaling by MET R-HSA-6806834 1.032722e-03 2.986 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.059601e-03 2.975 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.059601e-03 2.975 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.173491e-03 2.931 0 0
DNA Double Strand Break Response R-HSA-5693606 1.113616e-03 2.953 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.120562e-03 2.951 0 0
DNA Repair R-HSA-73894 1.106197e-03 2.956 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.314601e-03 2.881 0 0
Signaling by Hippo R-HSA-2028269 1.423928e-03 2.847 0 0
MET interacts with TNS proteins R-HSA-8875513 1.447983e-03 2.839 0 0
Apoptosis R-HSA-109581 1.472045e-03 2.832 0 0
Mitotic Anaphase R-HSA-68882 1.530126e-03 2.815 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.674082e-03 2.776 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.643919e-03 2.784 0 0
Membrane Trafficking R-HSA-199991 1.689939e-03 2.772 1 0
Regulation of CDH1 Function R-HSA-9764561 1.786032e-03 2.748 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.983903e-03 2.702 1 1
Transcriptional Regulation by TP53 R-HSA-3700989 1.987579e-03 2.702 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.114765e-03 2.675 1 0
Inhibition of DNA recombination at telomere R-HSA-9670095 2.211115e-03 2.655 0 0
Metabolism of non-coding RNA R-HSA-194441 2.370999e-03 2.625 0 0
snRNP Assembly R-HSA-191859 2.370999e-03 2.625 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.282402e-03 2.642 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.211115e-03 2.655 0 0
Signaling by RAS mutants R-HSA-6802949 2.450146e-03 2.611 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.450146e-03 2.611 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.450146e-03 2.611 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.450146e-03 2.611 0 0
DCC mediated attractive signaling R-HSA-418885 2.581929e-03 2.588 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 2.581929e-03 2.588 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.718248e-03 2.566 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.826098e-03 2.549 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 2.616337e-03 2.582 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.930516e-03 2.533 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.930516e-03 2.533 0 0
Formation of definitive endoderm R-HSA-9823730 3.099420e-03 2.509 0 0
Viral Messenger RNA Synthesis R-HSA-168325 3.106434e-03 2.508 0 0
Separation of Sister Chromatids R-HSA-2467813 3.248776e-03 2.488 0 0
EGFR downregulation R-HSA-182971 3.360305e-03 2.474 0 0
tRNA processing in the nucleus R-HSA-6784531 3.539089e-03 2.451 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.736933e-03 2.427 0 0
Reproduction R-HSA-1474165 4.279823e-03 2.369 0 0
Packaging Of Telomere Ends R-HSA-171306 4.959947e-03 2.305 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.882121e-03 2.311 0 0
Nuclear RNA decay R-HSA-9930044 4.818920e-03 2.317 0 0
HSF1-dependent transactivation R-HSA-3371571 5.073972e-03 2.295 0 0
PTEN Regulation R-HSA-6807070 5.092785e-03 2.293 0 0
mRNA Splicing - Major Pathway R-HSA-72163 5.240192e-03 2.281 0 0
MAPK family signaling cascades R-HSA-5683057 5.519221e-03 2.258 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.641621e-03 2.249 0 0
Nucleosome assembly R-HSA-774815 5.641621e-03 2.249 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 5.641621e-03 2.249 0 0
AURKA Activation by TPX2 R-HSA-8854518 5.790680e-03 2.237 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 5.801873e-03 2.236 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 6.254069e-03 2.204 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 6.604149e-03 2.180 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 6.493133e-03 2.188 0 0
Epigenetic regulation of gene expression R-HSA-212165 6.140511e-03 2.212 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 6.254069e-03 2.204 0 0
Signaling by FGFR in disease R-HSA-1226099 6.336407e-03 2.198 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 6.491986e-03 2.188 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 6.733641e-03 2.172 0 0
Ephrin signaling R-HSA-3928664 7.137755e-03 2.146 0 0
DNA methylation R-HSA-5334118 7.149022e-03 2.146 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 7.200777e-03 2.143 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 7.343130e-03 2.134 0 0
Recycling pathway of L1 R-HSA-437239 7.440431e-03 2.128 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 7.596949e-03 2.119 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 7.596949e-03 2.119 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 8.185712e-03 2.087 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 8.312661e-03 2.080 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 8.645016e-03 2.063 0 0
Regulation of CDH11 function R-HSA-9762292 8.645016e-03 2.063 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 8.882542e-03 2.051 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 9.553215e-03 2.020 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 9.376332e-03 2.028 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 9.376332e-03 2.028 0 0
HCMV Early Events R-HSA-9609690 1.012101e-02 1.995 0 0
mRNA Splicing R-HSA-72172 1.047001e-02 1.980 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.009015e-02 1.996 0 0
Signaling by VEGF R-HSA-194138 9.421551e-03 2.026 0 0
Developmental Biology R-HSA-1266738 9.411254e-03 2.026 0 0
ESR-mediated signaling R-HSA-8939211 9.860282e-03 2.006 0 0
HDMs demethylate histones R-HSA-3214842 1.065091e-02 1.973 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.065173e-02 1.973 0 0
HIV Life Cycle R-HSA-162587 1.127207e-02 1.948 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 1.160312e-02 1.935 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.160312e-02 1.935 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.172799e-02 1.931 0 0
Gene expression (Transcription) R-HSA-74160 1.199360e-02 1.921 0 0
Post NMDA receptor activation events R-HSA-438064 1.217962e-02 1.914 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.252944e-02 1.902 0 0
Metabolism of RNA R-HSA-8953854 1.256038e-02 1.901 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.299130e-02 1.886 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.334880e-02 1.875 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.365729e-02 1.865 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.365729e-02 1.865 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.365729e-02 1.865 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.377959e-02 1.861 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.387547e-02 1.858 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.595261e-02 1.797 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.581196e-02 1.801 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.598803e-02 1.796 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.409332e-02 1.851 0 0
Kinesins R-HSA-983189 1.506630e-02 1.822 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.494952e-02 1.825 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.506630e-02 1.822 0 0
Protein ubiquitination R-HSA-8852135 1.508730e-02 1.821 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.611089e-02 1.793 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.659214e-02 1.780 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.704483e-02 1.768 0 0
Inositol phosphate metabolism R-HSA-1483249 1.747483e-02 1.758 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.751642e-02 1.757 0 0
HIV elongation arrest and recovery R-HSA-167287 1.751642e-02 1.757 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.751642e-02 1.757 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.801157e-02 1.744 0 0
Programmed Cell Death R-HSA-5357801 1.801938e-02 1.744 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.830505e-02 1.737 0 0
Repression of WNT target genes R-HSA-4641265 1.943522e-02 1.711 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.990952e-02 1.701 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.990952e-02 1.701 0 0
RNA Polymerase I Transcription R-HSA-73864 1.994457e-02 1.700 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.029488e-02 1.693 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.029488e-02 1.693 0 0
Formation of annular gap junctions R-HSA-196025 2.179181e-02 1.662 0 0
EPH-Ephrin signaling R-HSA-2682334 2.047405e-02 1.689 0 0
Developmental Cell Lineages R-HSA-9734767 2.370862e-02 1.625 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.216861e-02 1.654 0 0
MAP2K and MAPK activation R-HSA-5674135 2.072769e-02 1.683 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.103749e-02 1.677 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 2.130425e-02 1.672 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.158200e-02 1.666 0 0
MTOR signalling R-HSA-165159 2.337594e-02 1.631 0 0
Assembly of the pre-replicative complex R-HSA-68867 2.219833e-02 1.654 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.038525e-02 1.691 0 0
Gap junction trafficking and regulation R-HSA-157858 2.262084e-02 1.645 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.179181e-02 1.662 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 2.337594e-02 1.631 0 0
Depyrimidination R-HSA-73928 2.337594e-02 1.631 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.376635e-02 1.624 0 0
HSF1 activation R-HSA-3371511 2.376635e-02 1.624 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.378721e-02 1.624 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.405669e-02 1.619 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.405669e-02 1.619 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.405669e-02 1.619 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.405669e-02 1.619 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.405669e-02 1.619 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.463207e-02 1.608 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.556324e-02 1.592 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.556324e-02 1.592 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.631509e-02 1.580 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.631509e-02 1.580 0 0
Death Receptor Signaling R-HSA-73887 2.679901e-02 1.572 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.695838e-02 1.569 0 0
Cleavage of the damaged purine R-HSA-110331 2.695838e-02 1.569 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 2.709450e-02 1.567 0 0
Meiotic recombination R-HSA-912446 2.803841e-02 1.552 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.995049e-02 1.524 0 0
Gap junction degradation R-HSA-190873 2.869702e-02 1.542 0 0
MET promotes cell motility R-HSA-8875878 3.044109e-02 1.517 0 0
mRNA 3'-end processing R-HSA-72187 3.107128e-02 1.508 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.107128e-02 1.508 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 3.107128e-02 1.508 0 0
Centrosome maturation R-HSA-380287 3.042233e-02 1.517 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.047094e-02 1.516 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 3.309833e-02 1.480 0 0
TGFBR3 expression R-HSA-9839394 3.059976e-02 1.514 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.309833e-02 1.480 0 0
Nephrin family interactions R-HSA-373753 3.399731e-02 1.469 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.995049e-02 1.524 0 0
Unwinding of DNA R-HSA-176974 2.869702e-02 1.542 0 0
Signaling by ERBB2 R-HSA-1227986 3.216639e-02 1.493 0 0
Long-term potentiation R-HSA-9620244 3.059976e-02 1.514 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.361607e-02 1.473 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.375375e-02 1.472 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.280562e-02 1.484 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 3.059976e-02 1.514 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 3.059976e-02 1.514 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 3.011592e-02 1.521 0 0
Signal transduction by L1 R-HSA-445144 3.399731e-02 1.469 0 0
Base Excision Repair R-HSA-73884 3.047094e-02 1.516 0 0
Depurination R-HSA-73927 3.044109e-02 1.517 0 0
Nucleotide Excision Repair R-HSA-5696398 3.432380e-02 1.464 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 3.433068e-02 1.464 0 0
MITF-M-dependent gene expression R-HSA-9856651 3.488161e-02 1.457 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.519872e-02 1.453 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 3.519872e-02 1.453 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.578194e-02 1.446 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 3.660776e-02 1.436 0 0
Folding of actin by CCT/TriC R-HSA-390450 3.676192e-02 1.435 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.676192e-02 1.435 0 0
Chromosome Maintenance R-HSA-73886 3.729354e-02 1.428 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 3.750885e-02 1.426 0 0
Generation of second messenger molecules R-HSA-202433 3.832222e-02 1.417 0 0
Aggrephagy R-HSA-9646399 3.832222e-02 1.417 0 0
Attenuation phase R-HSA-3371568 3.832222e-02 1.417 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 3.861537e-02 1.413 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 3.894623e-02 1.410 0 0
Striated Muscle Contraction R-HSA-390522 3.980668e-02 1.400 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 3.983260e-02 1.400 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 3.983260e-02 1.400 0 0
Interaction between L1 and Ankyrins R-HSA-445095 4.051914e-02 1.392 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 4.175077e-02 1.379 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 4.175077e-02 1.379 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 4.274025e-02 1.369 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.274025e-02 1.369 0 0
Mitotic G2-G2/M phases R-HSA-453274 4.317259e-02 1.365 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.348080e-02 1.362 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 4.389636e-02 1.358 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 4.469149e-02 1.350 0 0
DNA Replication Pre-Initiation R-HSA-69002 4.478512e-02 1.349 0 0
RAF activation R-HSA-5673000 4.479991e-02 1.349 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 4.479991e-02 1.349 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 5.620057e-02 1.250 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 5.620057e-02 1.250 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 5.620057e-02 1.250 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 5.620057e-02 1.250 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 5.620057e-02 1.250 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 5.620057e-02 1.250 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 5.620057e-02 1.250 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 5.620057e-02 1.250 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 5.620057e-02 1.250 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 5.620057e-02 1.250 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 5.620057e-02 1.250 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 5.620057e-02 1.250 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 5.620057e-02 1.250 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 5.553543e-02 1.255 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 5.553543e-02 1.255 0 0
Signaling by PDGFR in disease R-HSA-9671555 4.626590e-02 1.335 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 4.626590e-02 1.335 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.863428e-02 1.313 0 0
mTORC1-mediated signalling R-HSA-166208 5.330814e-02 1.273 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 4.546237e-02 1.342 0 0
Selective autophagy R-HSA-9663891 4.815639e-02 1.317 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 4.626590e-02 1.335 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 5.428975e-02 1.265 0 0
PECAM1 interactions R-HSA-210990 4.600187e-02 1.337 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 4.600506e-02 1.337 0 0
Regulation of gene expression in beta cells R-HSA-210745 5.232512e-02 1.281 0 0
NRAGE signals death through JNK R-HSA-193648 4.553921e-02 1.342 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 4.626590e-02 1.335 0 0
Telomere Maintenance R-HSA-157579 5.753093e-02 1.240 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.895903e-02 1.229 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 5.895903e-02 1.229 0 0
Regulation of TP53 Activity R-HSA-5633007 5.915184e-02 1.228 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 6.090455e-02 1.215 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 6.090455e-02 1.215 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 6.217469e-02 1.206 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 6.220999e-02 1.206 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 6.327610e-02 1.199 0 0
Netrin-1 signaling R-HSA-373752 6.377682e-02 1.195 0 0
Gap junction trafficking R-HSA-190828 6.377682e-02 1.195 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 6.608771e-02 1.180 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 6.692896e-02 1.174 0 0
Signaling by ALK in cancer R-HSA-9700206 6.692896e-02 1.174 0 0
Signaling by WNT R-HSA-195721 6.769617e-02 1.169 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 6.798374e-02 1.168 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 6.933471e-02 1.159 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 6.933471e-02 1.159 0 0
Glycolysis R-HSA-70171 6.939659e-02 1.159 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 6.990482e-02 1.155 0 0
GAB1 signalosome R-HSA-180292 7.062575e-02 1.151 0 0
Transport of connexons to the plasma membrane R-HSA-190872 7.062575e-02 1.151 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 7.119614e-02 1.148 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 7.119614e-02 1.148 0 0
SOS-mediated signalling R-HSA-112412 7.119614e-02 1.148 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 7.119614e-02 1.148 0 0
CHL1 interactions R-HSA-447041 7.119614e-02 1.148 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 7.119614e-02 1.148 0 0
Host Interactions of HIV factors R-HSA-162909 7.314594e-02 1.136 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 7.371361e-02 1.132 0 0
DNA strand elongation R-HSA-69190 7.371361e-02 1.132 0 0
ER to Golgi Anterograde Transport R-HSA-199977 7.472259e-02 1.127 0 0
Autophagy R-HSA-9612973 7.491051e-02 1.125 0 0
HIV Infection R-HSA-162906 7.576395e-02 1.121 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 7.597354e-02 1.119 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 7.880492e-02 1.103 0 0
Formation of axial mesoderm R-HSA-9796292 8.067662e-02 1.093 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 8.067662e-02 1.093 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 8.114757e-02 1.091 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 8.114757e-02 1.091 0 0
Integrin signaling R-HSA-354192 8.183661e-02 1.087 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 8.183661e-02 1.087 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 8.183661e-02 1.087 0 0
PKR-mediated signaling R-HSA-9833482 8.189036e-02 1.087 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 9.058542e-02 1.043 0 0
PDGFR mutants bind TKIs R-HSA-9674428 9.058542e-02 1.043 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 9.058542e-02 1.043 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 9.058542e-02 1.043 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 9.058542e-02 1.043 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 9.058542e-02 1.043 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 9.058542e-02 1.043 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 9.058542e-02 1.043 0 0
Signaling by FGFR1 amplification mutants R-HSA-1839120 8.262346e-02 1.083 0 0
MET activates PTPN11 R-HSA-8865999 8.262346e-02 1.083 0 0
Type I hemidesmosome assembly R-HSA-446107 8.859647e-02 1.053 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.075807e-01 0.968 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 9.245367e-02 1.034 0 0
Signaling by EGFR in Cancer R-HSA-1643713 8.764120e-02 1.057 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 9.774921e-02 1.010 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 9.774921e-02 1.010 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 9.774921e-02 1.010 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 9.045414e-02 1.044 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 8.324778e-02 1.080 0 0
DNA Damage Bypass R-HSA-73893 9.796868e-02 1.009 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 9.245367e-02 1.034 0 0
IRS-mediated signalling R-HSA-112399 9.583276e-02 1.018 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.092500e-01 0.962 0 0
PI3K Cascade R-HSA-109704 1.058700e-01 0.975 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 1.075807e-01 0.968 0 0
Oncogene Induced Senescence R-HSA-2559585 1.091502e-01 0.962 0 0
Myogenesis R-HSA-525793 8.764120e-02 1.057 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.075807e-01 0.968 0 0
IGF1R signaling cascade R-HSA-2428924 8.685399e-02 1.061 0 0
Signaling by FGFR4 in disease R-HSA-5655291 9.445003e-02 1.025 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.324551e-02 1.030 0 0
HCMV Infection R-HSA-9609646 8.951359e-02 1.048 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.092500e-01 0.962 0 0
Cilium Assembly R-HSA-5617833 1.039569e-01 0.983 0 0
Vesicle-mediated transport R-HSA-5653656 1.075601e-01 0.968 1 0
Protein methylation R-HSA-8876725 1.092500e-01 0.962 0 0
Regulation of KIT signaling R-HSA-1433559 9.445003e-02 1.025 0 0
Degradation of CDH1 R-HSA-9766229 9.796868e-02 1.009 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 9.667896e-02 1.015 0 0
G2/M Transition R-HSA-69275 8.855327e-02 1.053 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.092500e-01 0.962 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.092500e-01 0.962 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.029666e-01 0.987 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.116109e-01 0.952 0 0
Regulation of gap junction activity R-HSA-191650 1.120049e-01 0.951 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.120049e-01 0.951 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.120049e-01 0.951 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 1.120049e-01 0.951 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.120049e-01 0.951 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 1.120049e-01 0.951 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.120049e-01 0.951 0 0
NADE modulates death signalling R-HSA-205025 1.120049e-01 0.951 0 0
HCMV Late Events R-HSA-9610379 1.168190e-01 0.932 0 0
Signaling by SCF-KIT R-HSA-1433557 1.171143e-01 0.931 0 0
Defective pyroptosis R-HSA-9710421 1.171143e-01 0.931 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.173240e-01 0.931 0 0
S Phase R-HSA-69242 1.177612e-01 0.929 0 0
RET signaling R-HSA-8853659 1.192118e-01 0.924 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.197197e-01 0.922 0 0
G alpha (12/13) signalling events R-HSA-416482 1.236819e-01 0.908 0 0
Macroautophagy R-HSA-1632852 1.238093e-01 0.907 0 0
TCR signaling R-HSA-202403 1.262309e-01 0.899 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.279810e-01 0.893 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.279810e-01 0.893 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.293138e-01 0.888 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.308279e-01 0.883 0 0
Activation of the pre-replicative complex R-HSA-68962 1.315472e-01 0.881 0 0
Activation of BH3-only proteins R-HSA-114452 1.315472e-01 0.881 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.319140e-01 0.880 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.321264e-01 0.879 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.364359e-01 0.865 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 1.407030e-01 0.852 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.416731e-01 0.849 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.416731e-01 0.849 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 1.416731e-01 0.849 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.435929e-01 0.843 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.435929e-01 0.843 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 1.435929e-01 0.843 0 0
IRS activation R-HSA-74713 1.435929e-01 0.843 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 1.435929e-01 0.843 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 1.435929e-01 0.843 0 0
G2 Phase R-HSA-68911 1.435929e-01 0.843 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 1.435929e-01 0.843 0 0
NrCAM interactions R-HSA-447038 1.435929e-01 0.843 0 0
Semaphorin interactions R-HSA-373755 1.438234e-01 0.842 0 0
DNA Replication R-HSA-69306 1.442649e-01 0.841 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 1.449968e-01 0.839 0 0
Syndecan interactions R-HSA-3000170 1.449968e-01 0.839 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.449968e-01 0.839 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.462126e-01 0.835 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.462126e-01 0.835 0 0
Signaling by TGFBR3 R-HSA-9839373 1.466638e-01 0.834 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.729700e-01 0.762 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 1.729700e-01 0.762 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.729700e-01 0.762 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.729700e-01 0.762 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.729700e-01 0.762 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.729700e-01 0.762 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.729700e-01 0.762 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.729700e-01 0.762 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.729700e-01 0.762 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.729700e-01 0.762 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.478957e-01 0.606 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.478957e-01 0.606 0 0
Defective SLC26A2 causes chondrodysplasias R-HSA-3560792 2.478957e-01 0.606 0 0
Defective SLC34A2 causes PALM R-HSA-5687583 2.478957e-01 0.606 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.478957e-01 0.606 0 0
Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) R-HSA-5619045 2.478957e-01 0.606 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.478957e-01 0.606 0 0
Defective TPMT causes TPMT deficiency R-HSA-5578995 2.478957e-01 0.606 0 0
PKB-mediated events R-HSA-109703 1.767472e-01 0.753 0 0
PDE3B signalling R-HSA-165160 1.767472e-01 0.753 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 1.767472e-01 0.753 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.160375e-01 0.500 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 3.160375e-01 0.500 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.160375e-01 0.500 0 0
Signaling by RAS GAP mutants R-HSA-9753510 3.160375e-01 0.500 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.160375e-01 0.500 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.160375e-01 0.500 0 0
Defective ABCB6 causes MCOPCB7 R-HSA-5683371 3.160375e-01 0.500 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.160375e-01 0.500 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 2.109254e-01 0.676 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.109254e-01 0.676 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.496232e-01 0.825 0 0
Activation of RAC1 R-HSA-428540 1.723317e-01 0.764 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.723317e-01 0.764 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.723317e-01 0.764 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 2.456701e-01 0.610 0 0
Regulation of PTEN localization R-HSA-8948747 2.456701e-01 0.610 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.456701e-01 0.610 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 3.780092e-01 0.422 0 0
PLC-gamma1 signalling R-HSA-167021 3.780092e-01 0.422 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 3.780092e-01 0.422 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 3.780092e-01 0.422 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 3.780092e-01 0.422 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 3.780092e-01 0.422 0 0
MET activates RAS signaling R-HSA-8851805 1.959326e-01 0.708 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.959326e-01 0.708 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.959326e-01 0.708 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.959326e-01 0.708 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.959326e-01 0.708 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.959326e-01 0.708 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 2.805987e-01 0.552 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 2.805987e-01 0.552 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 2.805987e-01 0.552 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 2.805987e-01 0.552 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 2.805987e-01 0.552 0 0
MET receptor recycling R-HSA-8875656 2.805987e-01 0.552 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 2.805987e-01 0.552 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 2.202573e-01 0.657 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.597900e-01 0.796 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 2.451438e-01 0.611 0 0
Lipophagy R-HSA-9613354 3.153929e-01 0.501 0 0
WNT mediated activation of DVL R-HSA-201688 3.153929e-01 0.501 0 0
Calcineurin activates NFAT R-HSA-2025928 3.153929e-01 0.501 0 0
ALK mutants bind TKIs R-HSA-9700645 3.153929e-01 0.501 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 4.343692e-01 0.362 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.343692e-01 0.362 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.343692e-01 0.362 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 2.704390e-01 0.568 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.704390e-01 0.568 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.704390e-01 0.568 0 0
MET activates PTK2 signaling R-HSA-8874081 1.910739e-01 0.719 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 3.497907e-01 0.456 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 3.497907e-01 0.456 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 2.560405e-01 0.592 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 2.243064e-01 0.649 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 2.243064e-01 0.649 0 0
Formation of the Early Elongation Complex R-HSA-113418 2.243064e-01 0.649 0 0
Dual Incision in GG-NER R-HSA-5696400 1.981635e-01 0.703 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 2.127834e-01 0.672 0 0
Termination of translesion DNA synthesis R-HSA-5656169 2.415304e-01 0.617 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 2.767449e-01 0.558 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 2.767449e-01 0.558 0 0
FGFR2 alternative splicing R-HSA-6803529 2.767449e-01 0.558 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.216920e-01 0.493 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 3.835783e-01 0.416 0 0
Signaling by APC mutants R-HSA-4839744 3.835783e-01 0.416 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 3.835783e-01 0.416 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 3.835783e-01 0.416 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 3.835783e-01 0.416 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.603960e-01 0.795 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 2.277618e-01 0.643 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 2.977055e-01 0.526 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 2.977055e-01 0.526 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.473945e-01 0.459 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 3.473945e-01 0.459 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 4.165841e-01 0.380 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 4.165841e-01 0.380 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 4.165841e-01 0.380 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.165841e-01 0.380 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.719483e-01 0.765 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 3.729956e-01 0.428 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 3.729956e-01 0.428 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.564479e-01 0.591 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 3.400972e-01 0.468 0 0
Tight junction interactions R-HSA-420029 3.400972e-01 0.468 0 0
Germ layer formation at gastrulation R-HSA-9754189 3.983949e-01 0.400 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 3.983949e-01 0.400 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 4.486725e-01 0.348 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.486725e-01 0.348 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.486725e-01 0.348 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 4.486725e-01 0.348 0 0
Polymerase switching R-HSA-69091 4.486725e-01 0.348 0 0
Leading Strand Synthesis R-HSA-69109 4.486725e-01 0.348 0 0
Dual incision in TC-NER R-HSA-6782135 2.932776e-01 0.533 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 3.826550e-01 0.417 0 0
Regulation of RAS by GAPs R-HSA-5658442 3.149512e-01 0.502 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 4.235026e-01 0.373 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 4.235026e-01 0.373 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 4.235026e-01 0.373 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 4.235026e-01 0.373 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 4.038375e-01 0.394 0 0
Nuclear Receptor transcription pathway R-HSA-383280 3.038669e-01 0.517 0 0
RUNX2 regulates bone development R-HSA-8941326 3.873767e-01 0.412 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 2.960844e-01 0.529 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 4.482393e-01 0.348 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 4.482393e-01 0.348 0 0
Regulation of PTEN stability and activity R-HSA-8948751 3.602692e-01 0.443 0 0
Signaling by Erythropoietin R-HSA-9006335 4.248796e-01 0.372 0 0
Late endosomal microautophagy R-HSA-9615710 4.248796e-01 0.372 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 4.248796e-01 0.372 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.060683e-01 0.391 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.365533e-01 0.360 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 4.481689e-01 0.349 0 0
Transcription of the HIV genome R-HSA-167172 2.992639e-01 0.524 0 0
RNA Polymerase III Transcription R-HSA-74158 2.277618e-01 0.643 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.325963e-01 0.633 0 0
HIV Transcription Elongation R-HSA-167169 2.905790e-01 0.537 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.751644e-01 0.757 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 2.590926e-01 0.587 0 0
MHC class II antigen presentation R-HSA-2132295 1.641838e-01 0.785 0 0
Lagging Strand Synthesis R-HSA-69186 4.482393e-01 0.348 0 0
mRNA Capping R-HSA-72086 4.248796e-01 0.372 0 0
Protein folding R-HSA-391251 1.789170e-01 0.747 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 3.613881e-01 0.442 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 2.905790e-01 0.537 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.157142e-01 0.666 0 0
Receptor Mediated Mitophagy R-HSA-8934903 3.497907e-01 0.456 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.276134e-01 0.643 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.457294e-01 0.351 0 0
Frs2-mediated activation R-HSA-170968 2.202573e-01 0.657 0 0
Resolution of D-Loop Structures R-HSA-5693537 3.317285e-01 0.479 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 1.910739e-01 0.719 0 0
Signaling by FGFR1 R-HSA-5654736 1.603960e-01 0.795 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 3.133093e-01 0.504 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.629250e-01 0.788 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 2.456701e-01 0.610 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.456701e-01 0.610 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 1.591521e-01 0.798 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.567777e-01 0.805 0 0
PI3K/AKT activation R-HSA-198203 3.497907e-01 0.456 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.639171e-01 0.785 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 2.767449e-01 0.558 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 3.216920e-01 0.493 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 2.745083e-01 0.561 0 0
G-protein beta:gamma signalling R-HSA-397795 3.133093e-01 0.504 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 4.235026e-01 0.373 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.502424e-01 0.456 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 4.248796e-01 0.372 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 4.457294e-01 0.351 0 0
Netrin mediated repulsion signals R-HSA-418886 2.456701e-01 0.610 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 4.343692e-01 0.362 0 0
Trafficking of AMPA receptors R-HSA-399719 2.769429e-01 0.558 0 0
NF-kB is activated and signals survival R-HSA-209560 4.165841e-01 0.380 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 4.486725e-01 0.348 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 4.486725e-01 0.348 0 0
VLDLR internalisation and degradation R-HSA-8866427 4.486725e-01 0.348 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 4.165841e-01 0.380 0 0
Signaling by FGFR R-HSA-190236 2.421228e-01 0.616 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.546596e-01 0.811 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.074709e-01 0.683 0 0
Integration of provirus R-HSA-162592 4.165841e-01 0.380 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 4.486725e-01 0.348 0 0
DAP12 signaling R-HSA-2424491 4.457294e-01 0.351 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.745083e-01 0.561 0 0
Prolonged ERK activation events R-HSA-169893 2.959995e-01 0.529 0 0
Signaling by FGFR2 R-HSA-5654738 2.204338e-01 0.657 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 2.451438e-01 0.611 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.157142e-01 0.666 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 2.704390e-01 0.568 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.701296e-01 0.769 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.701296e-01 0.769 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.216920e-01 0.493 0 0
Synthesis of PI R-HSA-1483226 3.835783e-01 0.416 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.016446e-01 0.695 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.590926e-01 0.587 0 0
Fanconi Anemia Pathway R-HSA-6783310 2.423367e-01 0.616 0 0
Metalloprotease DUBs R-HSA-5689901 3.613881e-01 0.442 0 0
GRB2 events in EGFR signaling R-HSA-179812 4.486725e-01 0.348 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 4.482393e-01 0.348 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.194024e-01 0.377 0 0
Signaling by FGFR4 R-HSA-5654743 2.149104e-01 0.668 0 0
Ion homeostasis R-HSA-5578775 2.664143e-01 0.574 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 4.038375e-01 0.394 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 4.248796e-01 0.372 0 0
Signaling by ROBO receptors R-HSA-376176 3.655753e-01 0.437 0 0
Signaling by FGFR3 R-HSA-5654741 2.423367e-01 0.616 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 3.834048e-01 0.416 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.202573e-01 0.657 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 3.400972e-01 0.468 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.910739e-01 0.719 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.127834e-01 0.672 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.451438e-01 0.611 0 0
Insulin receptor signalling cascade R-HSA-74751 1.528496e-01 0.816 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 3.613881e-01 0.442 0 0
Co-inhibition by CTLA4 R-HSA-389513 4.235026e-01 0.373 0 0
Heme signaling R-HSA-9707616 3.486729e-01 0.458 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.643064e-01 0.439 0 0
Signalling to ERKs R-HSA-187687 3.688062e-01 0.433 0 0
Mismatch Repair R-HSA-5358508 1.773728e-01 0.751 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.914375e-01 0.407 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 3.400972e-01 0.468 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.495616e-01 0.825 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.342855e-01 0.630 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 3.613881e-01 0.442 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 2.109254e-01 0.676 0 0
Rap1 signalling R-HSA-392517 1.962542e-01 0.707 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.992639e-01 0.524 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.928247e-01 0.533 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.153929e-01 0.501 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 4.486725e-01 0.348 0 0
Ca2+ pathway R-HSA-4086398 2.454659e-01 0.610 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.457294e-01 0.351 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.792844e-01 0.554 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.704390e-01 0.568 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 2.149104e-01 0.668 0 0
p75NTR signals via NF-kB R-HSA-193639 2.704390e-01 0.568 0 0
Stabilization of p53 R-HSA-69541 4.427264e-01 0.354 0 0
Interferon Signaling R-HSA-913531 1.980785e-01 0.703 0 0
Co-inhibition by PD-1 R-HSA-389948 4.243618e-01 0.372 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.625002e-01 0.789 0 0
RNA Polymerase II Transcription R-HSA-73857 1.666721e-01 0.778 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 1.729700e-01 0.762 0 0
Inhibition of PKR R-HSA-169131 1.729700e-01 0.762 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.478957e-01 0.606 0 0
Manipulation of host energy metabolism R-HSA-9636667 2.478957e-01 0.606 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 1.767472e-01 0.753 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.160375e-01 0.500 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.160375e-01 0.500 0 0
C6 deamination of adenosine R-HSA-75102 3.160375e-01 0.500 0 0
Bicarbonate transporters R-HSA-425381 1.496232e-01 0.825 0 0
MET activates STAT3 R-HSA-8875791 3.780092e-01 0.422 0 0
Type II Na+/Pi cotransporters R-HSA-427589 3.780092e-01 0.422 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 2.805987e-01 0.552 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 2.202573e-01 0.657 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.202573e-01 0.657 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 2.202573e-01 0.657 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 3.153929e-01 0.501 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.153929e-01 0.501 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 3.497907e-01 0.456 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 3.497907e-01 0.456 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 2.959995e-01 0.529 0 0
Ionotropic activity of kainate receptors R-HSA-451306 3.835783e-01 0.416 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 3.188469e-01 0.496 0 0
Signaling by AXIN mutants R-HSA-4839735 4.165841e-01 0.380 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 2.257676e-01 0.646 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 3.983949e-01 0.400 0 0
Platelet calcium homeostasis R-HSA-418360 4.248796e-01 0.372 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 4.248796e-01 0.372 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.931998e-01 0.533 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 4.012657e-01 0.397 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 4.048704e-01 0.393 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 4.198844e-01 0.377 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.761258e-01 0.754 0 0
Generic Transcription Pathway R-HSA-212436 2.955191e-01 0.529 0 0
Signaling by FGFR3 in disease R-HSA-5655332 3.826550e-01 0.417 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.277618e-01 0.643 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 4.409354e-01 0.356 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 3.880419e-01 0.411 0 0
PKMTs methylate histone lysines R-HSA-3214841 3.068360e-01 0.513 0 0
Muscle contraction R-HSA-397014 4.460720e-01 0.351 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 3.983949e-01 0.400 0 0
p75NTR recruits signalling complexes R-HSA-209543 4.486725e-01 0.348 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.379112e-01 0.471 0 0
Signal attenuation R-HSA-74749 3.497907e-01 0.456 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 3.907887e-01 0.408 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 3.042424e-01 0.517 0 0
FLT3 signaling in disease R-HSA-9682385 2.277618e-01 0.643 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.984006e-01 0.702 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 2.560405e-01 0.592 0 0
FLT3 Signaling R-HSA-9607240 1.761258e-01 0.754 0 0
Negative regulation of FLT3 R-HSA-9706369 2.959995e-01 0.529 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 4.235026e-01 0.373 0 0
Ion transport by P-type ATPases R-HSA-936837 2.495213e-01 0.603 0 0
Early Phase of HIV Life Cycle R-HSA-162594 4.482393e-01 0.348 0 0
Neurodegenerative Diseases R-HSA-8863678 3.188469e-01 0.496 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.188469e-01 0.496 0 0
Cardiogenesis R-HSA-9733709 3.133093e-01 0.504 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.202573e-01 0.657 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 3.153929e-01 0.501 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.343692e-01 0.362 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.074709e-01 0.683 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.745083e-01 0.561 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 2.707907e-01 0.567 0 0
TNF signaling R-HSA-75893 2.664143e-01 0.574 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.902017e-01 0.409 0 0
Signaling by FGFR2 in disease R-HSA-5655253 3.149512e-01 0.502 0 0
NCAM signaling for neurite out-growth R-HSA-375165 2.257676e-01 0.646 0 0
Sensory processing of sound R-HSA-9659379 4.438984e-01 0.353 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 3.344335e-01 0.476 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 4.486725e-01 0.348 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 3.826550e-01 0.417 0 0
Co-stimulation by CD28 R-HSA-389356 4.396253e-01 0.357 0 0
Signaling by TGFB family members R-HSA-9006936 1.865824e-01 0.729 0 0
Formation of the ureteric bud R-HSA-9830674 2.977055e-01 0.526 0 0
Cellular responses to stress R-HSA-2262752 2.357418e-01 0.628 0 0
Cellular responses to stimuli R-HSA-8953897 2.194005e-01 0.659 0 0
Inhibition of membrane repair R-HSA-9635644 2.478957e-01 0.606 0 0
DSCAM interactions R-HSA-376172 3.160375e-01 0.500 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.109254e-01 0.676 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 3.780092e-01 0.422 0 0
ARMS-mediated activation R-HSA-170984 3.153929e-01 0.501 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.343692e-01 0.362 0 0
2-LTR circle formation R-HSA-164843 3.497907e-01 0.456 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.977055e-01 0.526 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 3.473945e-01 0.459 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.165841e-01 0.380 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 4.165841e-01 0.380 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.133093e-01 0.504 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 4.486725e-01 0.348 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 3.207510e-01 0.494 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 3.486729e-01 0.458 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 4.059126e-01 0.392 0 0
Potential therapeutics for SARS R-HSA-9679191 2.527742e-01 0.597 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 2.074709e-01 0.683 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.249969e-01 0.488 0 0
Basigin interactions R-HSA-210991 4.482393e-01 0.348 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.664143e-01 0.574 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.109254e-01 0.676 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.853395e-01 0.545 0 0
Diseases of programmed cell death R-HSA-9645723 2.173064e-01 0.663 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.025902e-01 0.693 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.153929e-01 0.501 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.497907e-01 0.456 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.560405e-01 0.592 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.284825e-01 0.641 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 2.745083e-01 0.561 0 0
DAG and IP3 signaling R-HSA-1489509 3.897364e-01 0.409 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 4.060683e-01 0.391 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 2.586588e-01 0.587 0 0
Signaling by ALK R-HSA-201556 4.427264e-01 0.354 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 2.959995e-01 0.529 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.933282e-01 0.714 0 0
Kidney development R-HSA-9830369 4.194024e-01 0.377 0 0
Signaling by NOTCH R-HSA-157118 1.636774e-01 0.786 0 0
SARS-CoV-1-host interactions R-HSA-9692914 4.451898e-01 0.351 0 0
Signal regulatory protein family interactions R-HSA-391160 2.451438e-01 0.611 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.153929e-01 0.501 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 3.835783e-01 0.416 0 0
Gap junction assembly R-HSA-190861 3.502424e-01 0.456 0 0
Influenza Infection R-HSA-168255 4.210921e-01 0.376 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.457294e-01 0.351 0 0
Josephin domain DUBs R-HSA-5689877 3.497907e-01 0.456 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 2.959995e-01 0.529 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 3.216920e-01 0.493 0 0
Specification of primordial germ cells R-HSA-9827857 3.473945e-01 0.459 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.469900e-01 0.607 0 0
Glucose metabolism R-HSA-70326 1.881913e-01 0.725 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 2.805987e-01 0.552 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 3.133093e-01 0.504 0 0
SLC transporter disorders R-HSA-5619102 3.104135e-01 0.508 0 0
OAS antiviral response R-HSA-8983711 4.486725e-01 0.348 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.135165e-01 0.671 0 0
Signaling by Leptin R-HSA-2586552 3.497907e-01 0.456 0 0
Interleukin-37 signaling R-HSA-9008059 4.457294e-01 0.351 0 0
Regulation of beta-cell development R-HSA-186712 4.517154e-01 0.345 0 0
Synthesis of DNA R-HSA-69239 4.565349e-01 0.341 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 4.609328e-01 0.336 0 0
Downstream signal transduction R-HSA-186763 4.663393e-01 0.331 0 0
Amyloid fiber formation R-HSA-977225 4.702730e-01 0.328 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 4.789615e-01 0.320 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 4.789615e-01 0.320 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 4.797389e-01 0.319 0 0
PLC beta mediated events R-HSA-112043 4.817773e-01 0.317 0 0
Hedgehog 'off' state R-HSA-5610787 4.843807e-01 0.315 0 0
FGFR1c and Klotho ligand binding and activation R-HSA-190374 4.856253e-01 0.314 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 4.856253e-01 0.314 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 4.856253e-01 0.314 0 0
Activation of AKT2 R-HSA-165158 4.856253e-01 0.314 0 0
Reelin signalling pathway R-HSA-8866376 4.856253e-01 0.314 0 0
Muscarinic acetylcholine receptors R-HSA-390648 4.856253e-01 0.314 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 4.856253e-01 0.314 0 0
Signaling by WNT in cancer R-HSA-4791275 4.866662e-01 0.313 0 0
G0 and Early G1 R-HSA-1538133 4.866662e-01 0.313 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 4.963307e-01 0.304 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 4.963307e-01 0.304 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 4.963307e-01 0.304 0 0
Signaling by KIT in disease R-HSA-9669938 4.963307e-01 0.304 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 4.963307e-01 0.304 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 4.967826e-01 0.304 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.967826e-01 0.304 0 0
Signaling by Insulin receptor R-HSA-74752 5.023776e-01 0.299 0 0
Neurexins and neuroligins R-HSA-6794361 5.047427e-01 0.297 0 0
Orc1 removal from chromatin R-HSA-68949 5.047427e-01 0.297 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 5.066712e-01 0.295 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 5.066712e-01 0.295 0 0
PI Metabolism R-HSA-1483255 5.077650e-01 0.294 0 0
Removal of the Flap Intermediate R-HSA-69166 5.097050e-01 0.293 0 0
Retrograde neurotrophin signalling R-HSA-177504 5.097050e-01 0.293 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 5.097050e-01 0.293 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.097050e-01 0.293 0 0
Ca-dependent events R-HSA-111996 5.143685e-01 0.289 0 0
Smooth Muscle Contraction R-HSA-445355 5.206134e-01 0.283 0 0
tRNA processing R-HSA-72306 5.267951e-01 0.278 0 0
Response of endothelial cells to shear stress R-HSA-9860931 5.308505e-01 0.275 0 0
TBC/RABGAPs R-HSA-8854214 5.316937e-01 0.274 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.322395e-01 0.274 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.322395e-01 0.274 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.322395e-01 0.274 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 5.322395e-01 0.274 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.322395e-01 0.274 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.322395e-01 0.274 0 0
Signaling by MAPK mutants R-HSA-9652817 5.322395e-01 0.274 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 5.322395e-01 0.274 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 5.322395e-01 0.274 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.322395e-01 0.274 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.322395e-01 0.274 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.322395e-01 0.274 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 5.322395e-01 0.274 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.322395e-01 0.274 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 5.322395e-01 0.274 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 5.322395e-01 0.274 0 0
Translation initiation complex formation R-HSA-72649 5.362796e-01 0.271 0 0
Erythropoietin activates RAS R-HSA-9027284 5.385151e-01 0.269 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 5.385151e-01 0.269 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 5.385151e-01 0.269 0 0
SHC1 events in EGFR signaling R-HSA-180336 5.385151e-01 0.269 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 5.385151e-01 0.269 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.385151e-01 0.269 0 0
p38MAPK events R-HSA-171007 5.385151e-01 0.269 0 0
Translesion synthesis by REV1 R-HSA-110312 5.385151e-01 0.269 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 5.385151e-01 0.269 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 5.385151e-01 0.269 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 5.385151e-01 0.269 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 5.385151e-01 0.269 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 5.422214e-01 0.266 0 0
Deadenylation of mRNA R-HSA-429947 5.422214e-01 0.266 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 5.455797e-01 0.263 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 5.455797e-01 0.263 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 5.455797e-01 0.263 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 5.455797e-01 0.263 0 0
Mitophagy R-HSA-5205647 5.455797e-01 0.263 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 5.455797e-01 0.263 0 0
NOD1/2 Signaling Pathway R-HSA-168638 5.455797e-01 0.263 0 0
Surfactant metabolism R-HSA-5683826 5.487355e-01 0.261 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 5.622588e-01 0.250 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 5.642381e-01 0.249 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 5.642381e-01 0.249 0 0
Laminin interactions R-HSA-3000157 5.642381e-01 0.249 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 5.642381e-01 0.249 0 0
Formation of the nephric duct R-HSA-9830364 5.642381e-01 0.249 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 5.642381e-01 0.249 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 5.644255e-01 0.248 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 5.644255e-01 0.248 0 0
Translesion synthesis by POLI R-HSA-5656121 5.661327e-01 0.247 0 0
Phosphorylation of the APC/C R-HSA-176412 5.661327e-01 0.247 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 5.661327e-01 0.247 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.661327e-01 0.247 0 0
Killing mechanisms R-HSA-9664420 5.661327e-01 0.247 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.661327e-01 0.247 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 5.661327e-01 0.247 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 5.661327e-01 0.247 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 5.669286e-01 0.246 0 0
G-protein mediated events R-HSA-112040 5.685915e-01 0.245 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 5.693399e-01 0.245 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 5.693399e-01 0.245 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 5.693399e-01 0.245 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 5.746318e-01 0.241 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 5.746318e-01 0.241 0 0
Signaling by LTK in cancer R-HSA-9842640 5.746318e-01 0.241 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.746318e-01 0.241 0 0
STAT5 Activation R-HSA-9645135 5.746318e-01 0.241 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 5.746318e-01 0.241 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 5.746318e-01 0.241 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 5.746318e-01 0.241 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 5.746318e-01 0.241 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 5.746318e-01 0.241 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 5.746318e-01 0.241 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 5.746318e-01 0.241 0 0
MET Receptor Activation R-HSA-6806942 5.746318e-01 0.241 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 5.746318e-01 0.241 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 5.818800e-01 0.235 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 5.818875e-01 0.235 0 0
Regulation of TNFR1 signaling R-HSA-5357905 5.818875e-01 0.235 0 0
Diseases of DNA repair R-HSA-9675135 5.818875e-01 0.235 0 0
Calmodulin induced events R-HSA-111933 5.828334e-01 0.234 0 0
CaM pathway R-HSA-111997 5.828334e-01 0.234 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 5.855951e-01 0.232 0 0
Rab regulation of trafficking R-HSA-9007101 5.881869e-01 0.230 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 5.925373e-01 0.227 0 0
Translesion synthesis by POLK R-HSA-5655862 5.925373e-01 0.227 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 5.925373e-01 0.227 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.925373e-01 0.227 0 0
Fibronectin matrix formation R-HSA-1566977 5.925373e-01 0.227 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 5.965643e-01 0.224 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 5.979629e-01 0.223 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 5.995469e-01 0.222 0 0
Degradation of DVL R-HSA-4641258 6.007835e-01 0.221 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 6.062705e-01 0.217 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 6.062705e-01 0.217 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 6.062705e-01 0.217 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 6.062705e-01 0.217 0 0
Insulin processing R-HSA-264876 6.062705e-01 0.217 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 6.088203e-01 0.216 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.093773e-01 0.215 0 0
Signaling by NTRKs R-HSA-166520 6.108794e-01 0.214 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.131845e-01 0.212 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.131845e-01 0.212 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 6.131845e-01 0.212 0 0
Recycling of eIF2:GDP R-HSA-72731 6.131845e-01 0.212 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 6.131845e-01 0.212 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.131845e-01 0.212 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.131845e-01 0.212 0 0
Mitochondrial ABC transporters R-HSA-1369007 6.131845e-01 0.212 0 0
VLDL clearance R-HSA-8964046 6.131845e-01 0.212 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.131845e-01 0.212 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.131845e-01 0.212 0 0
Intraflagellar transport R-HSA-5620924 6.136849e-01 0.212 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 6.177220e-01 0.209 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.177220e-01 0.209 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.177220e-01 0.209 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.177220e-01 0.209 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.177220e-01 0.209 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 6.182595e-01 0.209 0 0
Gastrulation R-HSA-9758941 6.199579e-01 0.208 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 6.225071e-01 0.206 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 6.262480e-01 0.203 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 6.290412e-01 0.201 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 6.290412e-01 0.201 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 6.290412e-01 0.201 0 0
Disorders of transmembrane transporters R-HSA-5619115 6.340601e-01 0.198 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 6.379462e-01 0.195 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 6.388993e-01 0.195 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 6.416908e-01 0.193 0 0
FGFR1 ligand binding and activation R-HSA-190242 6.416908e-01 0.193 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 6.416908e-01 0.193 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 6.416908e-01 0.193 0 0
Synaptic adhesion-like molecules R-HSA-8849932 6.416908e-01 0.193 0 0
Nephron development R-HSA-9831926 6.416908e-01 0.193 0 0
Circadian clock R-HSA-9909396 6.476434e-01 0.189 0 0
Adaptive Immune System R-HSA-1280218 6.477891e-01 0.189 0 0
phospho-PLA2 pathway R-HSA-111995 6.482451e-01 0.188 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 6.482451e-01 0.188 0 0
FGFR1b ligand binding and activation R-HSA-190370 6.482451e-01 0.188 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.482451e-01 0.188 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 6.482451e-01 0.188 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.482451e-01 0.188 0 0
Activation of RAS in B cells R-HSA-1169092 6.482451e-01 0.188 0 0
Sodium/Proton exchangers R-HSA-425986 6.482451e-01 0.188 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 6.482451e-01 0.188 0 0
Adrenoceptors R-HSA-390696 6.482451e-01 0.188 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 6.482451e-01 0.188 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 6.482451e-01 0.188 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 6.485492e-01 0.188 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 6.517385e-01 0.186 0 0
Signaling by PDGF R-HSA-186797 6.524070e-01 0.185 0 0
Signaling by ERBB4 R-HSA-1236394 6.603827e-01 0.180 0 0
SARS-CoV Infections R-HSA-9679506 6.635508e-01 0.178 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 6.640702e-01 0.178 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.644574e-01 0.178 0 0
Regulation of signaling by CBL R-HSA-912631 6.644574e-01 0.178 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.644574e-01 0.178 0 0
Translesion Synthesis by POLH R-HSA-110320 6.644574e-01 0.178 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.644574e-01 0.178 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 6.644574e-01 0.178 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 6.644574e-01 0.178 0 0
Specification of the neural plate border R-HSA-9834899 6.644574e-01 0.178 0 0
STING mediated induction of host immune responses R-HSA-1834941 6.644574e-01 0.178 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 6.656002e-01 0.177 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 6.656002e-01 0.177 0 0
Signaling by PTK6 R-HSA-8848021 6.656002e-01 0.177 0 0
Cytokine Signaling in Immune system R-HSA-1280215 6.709575e-01 0.173 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 6.728212e-01 0.172 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 6.728212e-01 0.172 0 0
G1/S Transition R-HSA-69206 6.768691e-01 0.169 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 6.801297e-01 0.167 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 6.801297e-01 0.167 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 6.801297e-01 0.167 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 6.801297e-01 0.167 0 0
p75NTR regulates axonogenesis R-HSA-193697 6.801297e-01 0.167 0 0
mRNA Editing R-HSA-75072 6.801297e-01 0.167 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 6.801297e-01 0.167 0 0
Regulation of signaling by NODAL R-HSA-1433617 6.801297e-01 0.167 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 6.801297e-01 0.167 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 6.801297e-01 0.167 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 6.801297e-01 0.167 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 6.831975e-01 0.165 0 0
UCH proteinases R-HSA-5689603 6.843090e-01 0.165 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.856661e-01 0.164 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 6.860427e-01 0.164 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 6.860427e-01 0.164 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.860427e-01 0.164 0 0
Signaling by NODAL R-HSA-1181150 6.860427e-01 0.164 0 0
Protein hydroxylation R-HSA-9629569 6.860427e-01 0.164 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 6.860427e-01 0.164 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 6.866287e-01 0.163 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 6.976900e-01 0.156 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 6.981579e-01 0.156 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 6.990283e-01 0.156 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.064737e-01 0.151 0 0
Signalling to RAS R-HSA-167044 7.064737e-01 0.151 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.064737e-01 0.151 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 7.064737e-01 0.151 0 0
Integrin cell surface interactions R-HSA-216083 7.071336e-01 0.150 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 7.091259e-01 0.149 0 0
Binding and entry of HIV virion R-HSA-173107 7.091259e-01 0.149 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.091259e-01 0.149 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.091259e-01 0.149 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.091259e-01 0.149 0 0
Pexophagy R-HSA-9664873 7.091259e-01 0.149 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 7.130404e-01 0.147 0 0
Signaling by NOTCH3 R-HSA-9012852 7.130404e-01 0.147 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 7.154398e-01 0.145 0 0
Neutrophil degranulation R-HSA-6798695 7.156685e-01 0.145 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 7.256416e-01 0.139 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.257824e-01 0.139 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 7.257824e-01 0.139 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.257824e-01 0.139 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.257824e-01 0.139 0 0
Serine metabolism R-HSA-977347 7.257824e-01 0.139 0 0
Parasite infection R-HSA-9664407 7.258432e-01 0.139 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 7.258432e-01 0.139 0 0
Leishmania phagocytosis R-HSA-9664417 7.258432e-01 0.139 0 0
G1 Phase R-HSA-69236 7.265366e-01 0.139 0 0
Cyclin D associated events in G1 R-HSA-69231 7.265366e-01 0.139 0 0
DAP12 interactions R-HSA-2172127 7.265366e-01 0.139 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 7.311497e-01 0.136 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 7.311497e-01 0.136 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 7.354952e-01 0.133 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 7.354952e-01 0.133 0 0
vRNP Assembly R-HSA-192905 7.354952e-01 0.133 0 0
vRNA Synthesis R-HSA-192814 7.354952e-01 0.133 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.354952e-01 0.133 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 7.354952e-01 0.133 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 7.354952e-01 0.133 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 7.354952e-01 0.133 0 0
Transport of RCbl within the body R-HSA-9758890 7.354952e-01 0.133 0 0
Adipogenesis R-HSA-9843745 7.375417e-01 0.132 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.392597e-01 0.131 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 7.399592e-01 0.131 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.440042e-01 0.128 0 0
LDL clearance R-HSA-8964038 7.440042e-01 0.128 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 7.461683e-01 0.127 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 7.488022e-01 0.126 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 7.528759e-01 0.123 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 7.528759e-01 0.123 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.592586e-01 0.120 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 7.594753e-01 0.119 0 0
DS-GAG biosynthesis R-HSA-2022923 7.594753e-01 0.119 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 7.594753e-01 0.119 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.594753e-01 0.119 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 7.594753e-01 0.119 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 7.594753e-01 0.119 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 7.594753e-01 0.119 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 7.594753e-01 0.119 0 0
Regulation of Apoptosis R-HSA-169911 7.605087e-01 0.119 0 0
Extension of Telomeres R-HSA-180786 7.610334e-01 0.119 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 7.610334e-01 0.119 0 0
Amino acid transport across the plasma membrane R-HSA-352230 7.610334e-01 0.119 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 7.611774e-01 0.119 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.611774e-01 0.119 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 7.611774e-01 0.119 0 0
Growth hormone receptor signaling R-HSA-982772 7.611774e-01 0.119 0 0
Opioid Signalling R-HSA-111885 7.617282e-01 0.118 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 7.652930e-01 0.116 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 7.652930e-01 0.116 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 7.695909e-01 0.114 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 7.695909e-01 0.114 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 7.741854e-01 0.111 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 7.741854e-01 0.111 0 0
FGFR2 mutant receptor activation R-HSA-1839126 7.741854e-01 0.111 0 0
GPER1 signaling R-HSA-9634597 7.772175e-01 0.109 0 0
NGF-stimulated transcription R-HSA-9031628 7.772175e-01 0.109 0 0
Gluconeogenesis R-HSA-70263 7.772175e-01 0.109 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 7.773425e-01 0.109 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 7.773425e-01 0.109 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 7.773425e-01 0.109 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 7.773425e-01 0.109 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 7.773425e-01 0.109 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 7.785517e-01 0.109 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.810936e-01 0.107 0 0
Maple Syrup Urine Disease R-HSA-9865114 7.812827e-01 0.107 0 0
Scavenging by Class F Receptors R-HSA-3000484 7.812827e-01 0.107 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 7.812827e-01 0.107 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 7.812827e-01 0.107 0 0
Regulation of IFNG signaling R-HSA-877312 7.812827e-01 0.107 0 0
Signaling by LTK R-HSA-9842663 7.812827e-01 0.107 0 0
Disorders of Nervous System Development R-HSA-9697154 7.812827e-01 0.107 0 0
Pervasive developmental disorders R-HSA-9005895 7.812827e-01 0.107 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 7.812827e-01 0.107 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 7.812827e-01 0.107 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 7.812827e-01 0.107 0 0
Interleukin-15 signaling R-HSA-8983432 7.812827e-01 0.107 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 7.812827e-01 0.107 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 7.871400e-01 0.104 0 0
Degradation of AXIN R-HSA-4641257 7.872146e-01 0.104 0 0
Ovarian tumor domain proteases R-HSA-5689896 7.872146e-01 0.104 0 0
Cap-dependent Translation Initiation R-HSA-72737 7.874262e-01 0.104 0 0
Eukaryotic Translation Initiation R-HSA-72613 7.874262e-01 0.104 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 7.925409e-01 0.101 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.925409e-01 0.101 0 0
Interleukin-7 signaling R-HSA-1266695 7.925409e-01 0.101 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 7.928696e-01 0.101 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 7.947322e-01 0.100 0 0
XBP1(S) activates chaperone genes R-HSA-381038 7.958764e-01 0.099 0 0
Signaling by Hedgehog R-HSA-5358351 7.970896e-01 0.098 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 7.983262e-01 0.098 0 0
Elastic fibre formation R-HSA-1566948 7.996138e-01 0.097 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 8.011141e-01 0.096 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.011141e-01 0.096 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.011141e-01 0.096 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 8.011141e-01 0.096 0 0
Processing of SMDT1 R-HSA-8949664 8.011141e-01 0.096 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.011141e-01 0.096 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.011141e-01 0.096 0 0
Maturation of nucleoprotein R-HSA-9683610 8.011141e-01 0.096 0 0
Interleukin-6 signaling R-HSA-1059683 8.011141e-01 0.096 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 8.027135e-01 0.095 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.068151e-01 0.093 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.068151e-01 0.093 0 0
Sphingolipid catabolism R-HSA-9845614 8.068151e-01 0.093 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 8.068151e-01 0.093 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.068151e-01 0.093 0 0
TRP channels R-HSA-3295583 8.068151e-01 0.093 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 8.068151e-01 0.093 0 0
Signaling by NOTCH1 R-HSA-1980143 8.072657e-01 0.093 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 8.101235e-01 0.091 0 0
Post-translational protein phosphorylation R-HSA-8957275 8.105604e-01 0.091 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 8.113470e-01 0.091 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.114015e-01 0.091 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.114015e-01 0.091 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.114015e-01 0.091 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 8.121836e-01 0.090 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.158931e-01 0.088 0 0
MyD88-independent TLR4 cascade R-HSA-166166 8.168075e-01 0.088 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 8.168075e-01 0.088 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 8.191484e-01 0.087 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 8.191484e-01 0.087 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.191484e-01 0.087 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 8.191484e-01 0.087 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 8.191484e-01 0.087 0 0
Hydrolysis of LPC R-HSA-1483115 8.191484e-01 0.087 0 0
NRIF signals cell death from the nucleus R-HSA-205043 8.191484e-01 0.087 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.191484e-01 0.087 0 0
cGMP effects R-HSA-418457 8.191484e-01 0.087 0 0
CRMPs in Sema3A signaling R-HSA-399956 8.191484e-01 0.087 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 8.191484e-01 0.087 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.191484e-01 0.087 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.191484e-01 0.087 0 0
Zinc transporters R-HSA-435354 8.191484e-01 0.087 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.201700e-01 0.086 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.201700e-01 0.086 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.201700e-01 0.086 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.202076e-01 0.086 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.225969e-01 0.085 0 0
Diseases of Immune System R-HSA-5260271 8.225969e-01 0.085 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 8.225969e-01 0.085 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 8.225969e-01 0.085 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.225969e-01 0.085 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.225969e-01 0.085 0 0
PCP/CE pathway R-HSA-4086400 8.242132e-01 0.084 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 8.265761e-01 0.083 0 0
SARS-CoV-2 Infection R-HSA-9694516 8.275028e-01 0.082 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 8.297739e-01 0.081 0 0
Interleukin-1 signaling R-HSA-9020702 8.325332e-01 0.080 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.327610e-01 0.079 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 8.327610e-01 0.079 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 8.332199e-01 0.079 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.355484e-01 0.078 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 8.355484e-01 0.078 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.355484e-01 0.078 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.355484e-01 0.078 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.355484e-01 0.078 0 0
Transport and metabolism of PAPS R-HSA-174362 8.355484e-01 0.078 0 0
Other semaphorin interactions R-HSA-416700 8.355484e-01 0.078 0 0
DNA Damage Reversal R-HSA-73942 8.355484e-01 0.078 0 0
SLC-mediated transport of amino acids R-HSA-9958863 8.384232e-01 0.077 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 8.389472e-01 0.076 0 0
Formation of the cornified envelope R-HSA-6809371 8.420302e-01 0.075 0 0
IRE1alpha activates chaperones R-HSA-381070 8.426548e-01 0.074 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.429380e-01 0.074 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.432908e-01 0.074 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 8.432908e-01 0.074 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 8.432908e-01 0.074 0 0
HIV Transcription Initiation R-HSA-167161 8.432908e-01 0.074 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.432908e-01 0.074 0 0
Intra-Golgi traffic R-HSA-6811438 8.432908e-01 0.074 0 0
Degradation of CRY and PER proteins R-HSA-9932298 8.432908e-01 0.074 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.432908e-01 0.074 0 0
DARPP-32 events R-HSA-180024 8.445172e-01 0.073 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.504621e-01 0.070 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.504621e-01 0.070 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.504621e-01 0.070 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.504621e-01 0.070 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 8.504621e-01 0.070 0 0
Differentiation of T cells R-HSA-9945266 8.504621e-01 0.070 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.504621e-01 0.070 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 8.504621e-01 0.070 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.555175e-01 0.068 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.555175e-01 0.068 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 8.561273e-01 0.067 0 0
COPII-mediated vesicle transport R-HSA-204005 8.615764e-01 0.065 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.618583e-01 0.065 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 8.618583e-01 0.065 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 8.620678e-01 0.064 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 8.640241e-01 0.063 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 8.640241e-01 0.063 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 8.640241e-01 0.063 0 0
Phase 2 - plateau phase R-HSA-5576893 8.640241e-01 0.063 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 8.640241e-01 0.063 0 0
Heme assimilation R-HSA-9927020 8.640241e-01 0.063 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 8.640241e-01 0.063 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 8.640241e-01 0.063 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 8.640241e-01 0.063 0 0
Synthesis of PG R-HSA-1483148 8.640241e-01 0.063 0 0
Disorders of Developmental Biology R-HSA-9675151 8.640241e-01 0.063 0 0
Coenzyme A biosynthesis R-HSA-196783 8.640241e-01 0.063 0 0
Platelet degranulation R-HSA-114608 8.649028e-01 0.063 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.658024e-01 0.063 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.658024e-01 0.063 0 0
Budding and maturation of HIV virion R-HSA-162588 8.658024e-01 0.063 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 8.658024e-01 0.063 0 0
Cargo concentration in the ER R-HSA-5694530 8.658024e-01 0.063 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.658024e-01 0.063 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.658024e-01 0.063 0 0
Regulation of mitotic cell cycle R-HSA-453276 8.686486e-01 0.061 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 8.686486e-01 0.061 0 0
Hedgehog 'on' state R-HSA-5632684 8.686486e-01 0.061 0 0
RMTs methylate histone arginines R-HSA-3214858 8.703962e-01 0.060 0 0
Mitochondrial biogenesis R-HSA-1592230 8.726837e-01 0.059 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 8.754110e-01 0.058 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.763569e-01 0.057 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 8.763569e-01 0.057 0 0
Glycogen storage diseases R-HSA-3229121 8.763569e-01 0.057 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.763569e-01 0.057 0 0
GDP-fucose biosynthesis R-HSA-6787639 8.763569e-01 0.057 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.763569e-01 0.057 0 0
Uptake and function of anthrax toxins R-HSA-5210891 8.763569e-01 0.057 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.784643e-01 0.056 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 8.784643e-01 0.056 0 0
Somitogenesis R-HSA-9824272 8.784643e-01 0.056 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.784643e-01 0.056 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.784643e-01 0.056 0 0
Interleukin-1 family signaling R-HSA-446652 8.811727e-01 0.055 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 8.814019e-01 0.055 0 0
Ion channel transport R-HSA-983712 8.866317e-01 0.052 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 8.875717e-01 0.052 0 0
Polo-like kinase mediated events R-HSA-156711 8.875717e-01 0.052 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 8.875717e-01 0.052 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 8.875717e-01 0.052 0 0
Presynaptic function of Kainate receptors R-HSA-500657 8.875717e-01 0.052 0 0
PKA activation in glucagon signalling R-HSA-164378 8.875717e-01 0.052 0 0
PKA activation R-HSA-163615 8.875717e-01 0.052 0 0
Platelet sensitization by LDL R-HSA-432142 8.875717e-01 0.052 0 0
Tie2 Signaling R-HSA-210993 8.875717e-01 0.052 0 0
Signaling by NOTCH4 R-HSA-9013694 8.880567e-01 0.052 0 0
Formation of paraxial mesoderm R-HSA-9793380 8.921643e-01 0.050 0 0
MAP kinase activation R-HSA-450294 8.921643e-01 0.050 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 8.926356e-01 0.049 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.927504e-01 0.049 0 0
Vpu mediated degradation of CD4 R-HSA-180534 8.927504e-01 0.049 0 0
Platelet activation, signaling and aggregation R-HSA-76002 8.933349e-01 0.049 0 0
Pyrimidine biosynthesis R-HSA-500753 8.977700e-01 0.047 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 8.977700e-01 0.047 0 0
The NLRP3 inflammasome R-HSA-844456 8.977700e-01 0.047 0 0
Other interleukin signaling R-HSA-449836 8.977700e-01 0.047 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 8.977700e-01 0.047 0 0
Maturation of nucleoprotein R-HSA-9694631 8.977700e-01 0.047 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 8.977700e-01 0.047 0 0
Transmission across Chemical Synapses R-HSA-112315 8.981825e-01 0.047 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 8.984840e-01 0.046 0 0
Hyaluronan metabolism R-HSA-2142845 9.005531e-01 0.045 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.005531e-01 0.045 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.005531e-01 0.045 0 0
Signal amplification R-HSA-392518 9.005531e-01 0.045 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.005531e-01 0.045 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.042236e-01 0.044 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.057680e-01 0.043 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 9.058472e-01 0.043 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.064387e-01 0.043 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.070437e-01 0.042 0 0
Glycogen synthesis R-HSA-3322077 9.070437e-01 0.042 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.070437e-01 0.042 0 0
Pregnenolone biosynthesis R-HSA-196108 9.070437e-01 0.042 0 0
Downstream TCR signaling R-HSA-202424 9.072231e-01 0.042 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.078233e-01 0.042 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.078233e-01 0.042 0 0
Post-translational protein modification R-HSA-597592 9.114153e-01 0.040 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.138845e-01 0.039 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.145936e-01 0.039 0 0
GPVI-mediated activation cascade R-HSA-114604 9.145936e-01 0.039 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.145936e-01 0.039 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.149326e-01 0.039 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 9.150732e-01 0.039 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.154767e-01 0.038 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.154767e-01 0.038 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 9.154767e-01 0.038 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.154767e-01 0.038 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.154767e-01 0.038 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.154767e-01 0.038 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.179655e-01 0.037 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.181169e-01 0.037 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 9.195701e-01 0.036 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.206752e-01 0.036 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.208946e-01 0.036 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.208946e-01 0.036 0 0
CS-GAG biosynthesis R-HSA-2022870 9.231451e-01 0.035 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.231451e-01 0.035 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.231451e-01 0.035 0 0
Assembly Of The HIV Virion R-HSA-175474 9.231451e-01 0.035 0 0
Glutathione synthesis and recycling R-HSA-174403 9.231451e-01 0.035 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.231451e-01 0.035 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.239835e-01 0.034 0 0
Signaling by Interleukins R-HSA-449147 9.243488e-01 0.034 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.267558e-01 0.033 0 0
Viral Infection Pathways R-HSA-9824446 9.276145e-01 0.033 0 0
Notch-HLH transcription pathway R-HSA-350054 9.301181e-01 0.031 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 9.301181e-01 0.031 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.301181e-01 0.031 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.301181e-01 0.031 0 0
RAS processing R-HSA-9648002 9.322052e-01 0.030 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.322052e-01 0.030 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 9.323885e-01 0.030 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 9.331541e-01 0.030 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 9.353541e-01 0.029 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 9.353541e-01 0.029 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.364589e-01 0.029 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.364589e-01 0.029 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.364589e-01 0.029 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.364589e-01 0.029 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.364589e-01 0.029 0 0
Carnitine shuttle R-HSA-200425 9.364589e-01 0.029 0 0
Glycogen metabolism R-HSA-8982491 9.372691e-01 0.028 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.372691e-01 0.028 0 0
Cardiac conduction R-HSA-5576891 9.374930e-01 0.028 0 0
Interleukin-17 signaling R-HSA-448424 9.375414e-01 0.028 0 0
Paracetamol ADME R-HSA-9753281 9.375718e-01 0.028 0 0
Cellular response to chemical stress R-HSA-9711123 9.408871e-01 0.026 0 0
ECM proteoglycans R-HSA-3000178 9.413283e-01 0.026 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.419726e-01 0.026 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.419726e-01 0.026 0 0
Complex III assembly R-HSA-9865881 9.422247e-01 0.026 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.422247e-01 0.026 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.422247e-01 0.026 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.422247e-01 0.026 0 0
Interleukin-6 family signaling R-HSA-6783589 9.422247e-01 0.026 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.429729e-01 0.026 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 9.442160e-01 0.025 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 9.442160e-01 0.025 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 9.449047e-01 0.025 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 9.456136e-01 0.024 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 9.456136e-01 0.024 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 9.456136e-01 0.024 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.463395e-01 0.024 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.471063e-01 0.024 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.474676e-01 0.023 0 0
Hyaluronan degradation R-HSA-2160916 9.474676e-01 0.023 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.474676e-01 0.023 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.503920e-01 0.022 0 0
ABC-family proteins mediated transport R-HSA-382556 9.513146e-01 0.022 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.516271e-01 0.022 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.522350e-01 0.021 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.522350e-01 0.021 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.522350e-01 0.021 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.526733e-01 0.021 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.541513e-01 0.020 0 0
tRNA Aminoacylation R-HSA-379724 9.558754e-01 0.020 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 9.558754e-01 0.020 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 9.558754e-01 0.020 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 9.558754e-01 0.020 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 9.558754e-01 0.020 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 9.558754e-01 0.020 0 0
Cristae formation R-HSA-8949613 9.565701e-01 0.019 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.565701e-01 0.019 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 9.565701e-01 0.019 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.565701e-01 0.019 0 0
Interleukin-12 signaling R-HSA-9020591 9.573019e-01 0.019 0 0
Proteasome assembly R-HSA-9907900 9.576371e-01 0.019 0 0
Methylation R-HSA-156581 9.576371e-01 0.019 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.576371e-01 0.019 0 0
Amine ligand-binding receptors R-HSA-375280 9.576371e-01 0.019 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 9.585247e-01 0.018 0 0
Telomere Extension By Telomerase R-HSA-171319 9.605119e-01 0.017 0 0
Inflammasomes R-HSA-622312 9.605119e-01 0.017 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.605119e-01 0.017 0 0
Iron assimilation using enterobactin R-HSA-9638334 9.605119e-01 0.017 0 0
Pyroptosis R-HSA-5620971 9.605119e-01 0.017 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.606965e-01 0.017 0 0
Toll-like Receptor Cascades R-HSA-168898 9.608470e-01 0.017 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.608681e-01 0.017 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.608681e-01 0.017 0 0
ABC transporter disorders R-HSA-5619084 9.624833e-01 0.017 0 0
Interleukin-10 signaling R-HSA-6783783 9.624833e-01 0.017 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.640961e-01 0.016 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 9.640961e-01 0.016 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.640961e-01 0.016 0 0
rRNA processing R-HSA-72312 9.655759e-01 0.015 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.666977e-01 0.015 0 0
Neurotransmitter clearance R-HSA-112311 9.673553e-01 0.014 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.673553e-01 0.014 0 0
Metal ion SLC transporters R-HSA-425410 9.692024e-01 0.014 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 9.708508e-01 0.013 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 9.708508e-01 0.013 0 0
Stimuli-sensing channels R-HSA-2672351 9.708508e-01 0.013 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.712009e-01 0.013 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.715789e-01 0.013 0 0
Interferon gamma signaling R-HSA-877300 9.717671e-01 0.012 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 9.725042e-01 0.012 0 0
Hemostasis R-HSA-109582 9.725330e-01 0.012 0 0
Azathioprine ADME R-HSA-9748787 9.737780e-01 0.012 0 0
Regulation of necroptotic cell death R-HSA-5675482 9.754634e-01 0.011 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.758122e-01 0.011 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.769594e-01 0.010 0 0
Parasitic Infection Pathways R-HSA-9824443 9.772922e-01 0.010 0 0
Leishmania infection R-HSA-9658195 9.772922e-01 0.010 0 0
Neuronal System R-HSA-112316 9.773124e-01 0.010 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.776912e-01 0.010 0 0
CS/DS degradation R-HSA-2024101 9.776912e-01 0.010 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.776912e-01 0.010 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.776912e-01 0.010 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.776912e-01 0.010 0 0
Heme degradation R-HSA-189483 9.776912e-01 0.010 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 9.782891e-01 0.010 0 0
FOXO-mediated transcription R-HSA-9614085 9.784380e-01 0.009 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.797169e-01 0.009 0 0
eNOS activation R-HSA-203615 9.797169e-01 0.009 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.797169e-01 0.009 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.797169e-01 0.009 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.797169e-01 0.009 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.801307e-01 0.009 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.803841e-01 0.009 0 0
Interleukin-12 family signaling R-HSA-447115 9.806902e-01 0.008 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.813878e-01 0.008 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.815587e-01 0.008 0 0
PERK regulates gene expression R-HSA-381042 9.815587e-01 0.008 0 0
Peptide chain elongation R-HSA-156902 9.819577e-01 0.008 0 0
G alpha (z) signalling events R-HSA-418597 9.825249e-01 0.008 0 0
ER-Phagosome pathway R-HSA-1236974 9.831461e-01 0.007 0 0
G1/S-Specific Transcription R-HSA-69205 9.832334e-01 0.007 0 0
Neurotransmitter release cycle R-HSA-112310 9.842601e-01 0.007 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.843169e-01 0.007 0 0
Voltage gated Potassium channels R-HSA-1296072 9.847561e-01 0.007 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.847561e-01 0.007 0 0
NCAM1 interactions R-HSA-419037 9.847561e-01 0.007 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.847561e-01 0.007 0 0
Metabolism of folate and pterines R-HSA-196757 9.847561e-01 0.007 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.847690e-01 0.007 0 0
Immune System R-HSA-168256 9.849632e-01 0.007 0 0
Dectin-2 family R-HSA-5621480 9.851637e-01 0.006 0 0
RSV-host interactions R-HSA-9833110 9.852952e-01 0.006 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.861405e-01 0.006 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.861405e-01 0.006 0 0
Platelet homeostasis R-HSA-418346 9.870816e-01 0.006 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.873994e-01 0.006 0 0
Peroxisomal protein import R-HSA-9033241 9.874132e-01 0.006 0 0
Metabolism of polyamines R-HSA-351202 9.884096e-01 0.005 0 0
Interleukin-2 family signaling R-HSA-451927 9.885439e-01 0.005 0 0
Tryptophan catabolism R-HSA-71240 9.885439e-01 0.005 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.886615e-01 0.005 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.889364e-01 0.005 0 0
Maturation of spike protein R-HSA-9694548 9.895846e-01 0.005 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.895846e-01 0.005 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.903111e-01 0.004 0 0
Translation of Structural Proteins R-HSA-9683701 9.905307e-01 0.004 0 0
Neddylation R-HSA-8951664 9.907151e-01 0.004 0 0
Activation of GABAB receptors R-HSA-991365 9.913910e-01 0.004 0 0
GABA B receptor activation R-HSA-977444 9.913910e-01 0.004 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.913910e-01 0.004 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.913910e-01 0.004 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.918197e-01 0.004 0 0
Regulation of insulin secretion R-HSA-422356 9.921561e-01 0.003 0 0
Cellular response to hypoxia R-HSA-1234174 9.923450e-01 0.003 0 0
PPARA activates gene expression R-HSA-1989781 9.925081e-01 0.003 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.928843e-01 0.003 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.928843e-01 0.003 0 0
G alpha (s) signalling events R-HSA-418555 9.933507e-01 0.003 1 1
Peptide ligand-binding receptors R-HSA-375276 9.934545e-01 0.003 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.935309e-01 0.003 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.935309e-01 0.003 0 0
Sphingolipid metabolism R-HSA-428157 9.936238e-01 0.003 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.939703e-01 0.003 0 0
Regulated Necrosis R-HSA-5218859 9.940425e-01 0.003 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.941187e-01 0.003 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.941187e-01 0.003 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.941187e-01 0.003 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.941995e-01 0.003 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.946532e-01 0.002 0 0
Metal ion assimilation from the host R-HSA-9638482 9.953694e-01 0.002 0 0
Integration of energy metabolism R-HSA-163685 9.962523e-01 0.002 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.963477e-01 0.002 0 0
The phototransduction cascade R-HSA-2514856 9.963477e-01 0.002 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.964884e-01 0.002 0 0
Protein localization R-HSA-9609507 9.966924e-01 0.001 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.969816e-01 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 9.969816e-01 0.001 0 0
Collagen formation R-HSA-1474290 9.969954e-01 0.001 0 0
Translation of Structural Proteins R-HSA-9694635 9.972121e-01 0.001 0 0
Glucuronidation R-HSA-156588 9.972560e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.972585e-01 0.001 0 0
Eukaryotic Translation Termination R-HSA-72764 9.974309e-01 0.001 0 0
Extracellular matrix organization R-HSA-1474244 9.974580e-01 0.001 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.975055e-01 0.001 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.977323e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.979385e-01 0.001 0 0
Keratinization R-HSA-6805567 9.980137e-01 0.001 0 0
Phospholipid metabolism R-HSA-1483257 9.981107e-01 0.001 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.981174e-01 0.001 0 0
Interferon alpha/beta signaling R-HSA-909733 9.981635e-01 0.001 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.983991e-01 0.001 0 0
Peptide hormone metabolism R-HSA-2980736 9.984176e-01 0.001 0 0
GABA receptor activation R-HSA-977443 9.984513e-01 0.001 0 0
Glutathione conjugation R-HSA-156590 9.984513e-01 0.001 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.984656e-01 0.001 0 0
Aquaporin-mediated transport R-HSA-445717 9.985922e-01 0.001 0 0
Mitochondrial protein import R-HSA-1268020 9.987202e-01 0.001 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.992056e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.992056e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.992056e-01 0.000 0 0
Cellular response to starvation R-HSA-9711097 9.992065e-01 0.000 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.992293e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.992575e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.992779e-01 0.000 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.992931e-01 0.000 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.993517e-01 0.000 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.993876e-01 0.000 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.993876e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.994034e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.994056e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.994577e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.994577e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.994577e-01 0.000 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.995003e-01 0.000 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.995419e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.995519e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.995519e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.995800e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.996013e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.996766e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.997219e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.997219e-01 0.000 0 0
Selenocysteine synthesis R-HSA-2408557 9.997284e-01 0.000 0 0
Ribosome-associated quality control R-HSA-9948299 9.997460e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.997473e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.997720e-01 0.000 0 0
Viral mRNA Translation R-HSA-192823 9.997720e-01 0.000 0 0
Translation R-HSA-72766 9.998465e-01 0.000 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.998530e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.998647e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.998871e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999197e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999250e-01 0.000 1 0
Disease R-HSA-1643685 9.999330e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999345e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999345e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999391e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999415e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.999502e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999533e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999588e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999611e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999626e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.999626e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999642e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999651e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999691e-01 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 9.999700e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999786e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999888e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999902e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999919e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999936e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999940e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999965e-01 0.000 1 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999974e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999979e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999981e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999982e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999984e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999992e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999992e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999993e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999993e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999996e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999998e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999998e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999999e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999999e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999999e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.999999e-01 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cellular response to heat stress R-HSA-3371556 5.839773e-14 13.234 0 0
HSF1-dependent transactivation R-HSA-3371571 4.126810e-12 11.384 0 0
Cell Cycle R-HSA-1640170 5.366152e-12 11.270 0 0
Attenuation phase R-HSA-3371568 7.277956e-11 10.138 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.483184e-10 9.829 0 0
Cell Cycle, Mitotic R-HSA-69278 2.103961e-10 9.677 0 0
M Phase R-HSA-68886 2.484013e-09 8.605 0 0
HSF1 activation R-HSA-3371511 8.076197e-09 8.093 0 0
Mitotic Prometaphase R-HSA-68877 1.100084e-07 6.959 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.864971e-07 6.543 0 0
Mitotic Anaphase R-HSA-68882 5.550522e-07 6.256 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 6.298426e-07 6.201 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 7.378337e-07 6.132 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.121081e-06 5.950 0 0
Cell Cycle Checkpoints R-HSA-69620 1.954923e-06 5.709 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.086845e-06 5.681 0 0
Metabolism of RNA R-HSA-8953854 2.630719e-06 5.580 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.877549e-06 5.541 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.853674e-06 5.414 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 4.867448e-06 5.313 0 0
Amplification of signal from the kinetochores R-HSA-141424 4.867448e-06 5.313 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 4.578494e-06 5.339 0 0
Cellular responses to stimuli R-HSA-8953897 6.028618e-06 5.220 0 0
Separation of Sister Chromatids R-HSA-2467813 6.581336e-06 5.182 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.505384e-05 4.822 0 0
Apoptotic execution phase R-HSA-75153 1.756649e-05 4.755 0 0
mRNA 3'-end processing R-HSA-72187 2.277195e-05 4.643 0 0
Cellular responses to stress R-HSA-2262752 2.216082e-05 4.654 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.610394e-05 4.583 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 3.395893e-05 4.469 0 0
Mitotic Prophase R-HSA-68875 3.389830e-05 4.470 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.395893e-05 4.469 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.675911e-05 4.435 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 5.232026e-05 4.281 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 6.244872e-05 4.204 0 0
Nuclear Envelope Breakdown R-HSA-2980766 6.737455e-05 4.172 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 8.418139e-05 4.075 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 8.901207e-05 4.051 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.599459e-04 3.796 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.583239e-04 3.800 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.740628e-04 3.759 0 0
Membrane Trafficking R-HSA-199991 1.762649e-04 3.754 1 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.880286e-04 3.726 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.242607e-04 3.649 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.762733e-04 3.559 0 0
Nuclear import of Rev protein R-HSA-180746 2.864377e-04 3.543 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.012999e-04 3.521 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 3.567777e-04 3.448 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 3.567777e-04 3.448 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.628447e-04 3.440 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 5.787073e-04 3.238 0 0
ISG15 antiviral mechanism R-HSA-1169408 5.979506e-04 3.223 0 0
Metabolism of non-coding RNA R-HSA-194441 7.318452e-04 3.136 0 0
snRNP Assembly R-HSA-191859 7.318452e-04 3.136 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 7.275704e-04 3.138 0 0
mRNA Splicing - Major Pathway R-HSA-72163 7.443232e-04 3.128 0 0
G alpha (12/13) signalling events R-HSA-416482 9.260935e-04 3.033 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.059164e-03 2.975 0 0
PKR-mediated signaling R-HSA-9833482 1.222361e-03 2.913 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.286307e-03 2.891 0 0
Chromatin organization R-HSA-4839726 1.342350e-03 2.872 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.450647e-03 2.838 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.552820e-03 2.809 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.553031e-03 2.809 0 0
mRNA Splicing R-HSA-72172 1.851124e-03 2.733 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.040800e-03 2.690 0 0
Striated Muscle Contraction R-HSA-390522 2.201219e-03 2.657 0 0
Chromatin modifying enzymes R-HSA-3247509 2.120248e-03 2.674 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.335753e-03 2.632 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.723121e-03 2.565 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 2.831459e-03 2.548 0 0
Early Phase of HIV Life Cycle R-HSA-162594 3.017710e-03 2.520 0 0
Aggrephagy R-HSA-9646399 2.942793e-03 2.531 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.195174e-03 2.496 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 3.274356e-03 2.485 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 3.274356e-03 2.485 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.696631e-03 2.432 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 3.761161e-03 2.425 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 3.668366e-03 2.436 0 0
Signaling downstream of RAS mutants R-HSA-9649948 3.668366e-03 2.436 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 3.668366e-03 2.436 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 3.760775e-03 2.425 0 0
Signaling by RAS mutants R-HSA-6802949 3.668366e-03 2.436 0 0
Signaling by Hippo R-HSA-2028269 3.764588e-03 2.424 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.668366e-03 2.436 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 4.584832e-03 2.339 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 4.584832e-03 2.339 0 0
Chaperone Mediated Autophagy R-HSA-9613829 4.883128e-03 2.311 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 4.650242e-03 2.333 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 4.650242e-03 2.333 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.614222e-03 2.336 0 0
AURKA Activation by TPX2 R-HSA-8854518 4.887439e-03 2.311 0 0
Oncogenic MAPK signaling R-HSA-6802957 4.941373e-03 2.306 0 0
Kinesins R-HSA-983189 4.983189e-03 2.302 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 5.160827e-03 2.287 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 5.720708e-03 2.243 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 5.371437e-03 2.270 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 5.516717e-03 2.258 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 5.371437e-03 2.270 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 6.093520e-03 2.215 0 0
Heme signaling R-HSA-9707616 6.481429e-03 2.188 0 0
tRNA processing in the nucleus R-HSA-6784531 6.481429e-03 2.188 0 0
Centrosome maturation R-HSA-380287 6.807156e-03 2.167 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 6.999172e-03 2.155 0 0
Signaling by AXIN mutants R-HSA-4839735 7.379790e-03 2.132 0 0
Signaling by GSK3beta mutants R-HSA-5339716 7.379790e-03 2.132 0 0
RAF activation R-HSA-5673000 7.354909e-03 2.133 0 0
Integration of provirus R-HSA-162592 7.379790e-03 2.132 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 7.734263e-03 2.112 0 0
Apoptosis R-HSA-109581 8.107381e-03 2.091 0 0
Activation of the pre-replicative complex R-HSA-68962 8.229681e-03 2.085 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 8.229681e-03 2.085 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 8.606228e-03 2.065 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 8.999695e-03 2.046 0 0
PKMTs methylate histone lysines R-HSA-3214841 8.908027e-03 2.050 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 8.694606e-03 2.061 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 9.075889e-03 2.042 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 9.075889e-03 2.042 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 9.914935e-03 2.004 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 9.914935e-03 2.004 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 9.914935e-03 2.004 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 9.914935e-03 2.004 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 9.914935e-03 2.004 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.286936e-03 2.032 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 9.381440e-03 2.028 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 9.249358e-03 2.034 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 9.996333e-03 2.000 0 0
Signaling by ALK in cancer R-HSA-9700206 9.249358e-03 2.034 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 9.608622e-03 2.017 0 0
Smooth Muscle Contraction R-HSA-445355 1.006482e-02 1.997 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.017997e-02 1.992 0 0
MAP2K and MAPK activation R-HSA-5674135 1.034122e-02 1.985 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.036469e-02 1.984 0 0
Signal Transduction R-HSA-162582 1.069171e-02 1.971 1 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.097304e-02 1.960 0 0
Cellular Senescence R-HSA-2559583 1.126706e-02 1.948 0 0
Translation initiation complex formation R-HSA-72649 1.144410e-02 1.941 0 0
Signaling by WNT in cancer R-HSA-4791275 1.164373e-02 1.934 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.189730e-02 1.925 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.182845e-02 1.927 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.189730e-02 1.925 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.251586e-02 1.903 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 1.301499e-02 1.886 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.301499e-02 1.886 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.301499e-02 1.886 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.301499e-02 1.886 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.370704e-02 1.863 0 0
S Phase R-HSA-69242 1.391832e-02 1.856 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.396488e-02 1.855 0 0
Programmed Cell Death R-HSA-5357801 1.458060e-02 1.836 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.464083e-02 1.834 0 0
mTORC1-mediated signalling R-HSA-166208 1.465465e-02 1.834 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.564118e-02 1.806 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.601791e-02 1.795 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.623678e-02 1.790 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.144019e-02 1.669 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.144019e-02 1.669 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.144019e-02 1.669 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.144019e-02 1.669 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.144019e-02 1.669 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.144019e-02 1.669 0 0
Signaling by APC mutants R-HSA-4839744 2.151776e-02 1.667 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.151776e-02 1.667 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.151776e-02 1.667 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.151776e-02 1.667 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.113293e-02 1.675 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.113293e-02 1.675 0 0
G beta:gamma signalling through BTK R-HSA-8964315 2.113293e-02 1.675 0 0
Thromboxane signalling through TP receptor R-HSA-428930 2.107518e-02 1.676 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.186544e-02 1.660 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.107518e-02 1.676 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.020050e-02 1.695 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.020050e-02 1.695 0 0
G2/M Checkpoints R-HSA-69481 1.948417e-02 1.710 0 0
Interferon Signaling R-HSA-913531 1.763825e-02 1.754 0 0
Neurodegenerative Diseases R-HSA-8863678 2.107518e-02 1.676 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.107518e-02 1.676 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.154254e-02 1.667 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.792115e-02 1.747 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.106914e-02 1.676 0 0
HATs acetylate histones R-HSA-3214847 2.540447e-02 1.595 0 0
Prolonged ERK activation events R-HSA-169893 2.625003e-02 1.581 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.679669e-02 1.572 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.780496e-02 1.556 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.918534e-02 1.535 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.927013e-02 1.534 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.927013e-02 1.534 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 3.042983e-02 1.517 0 0
DNA Double-Strand Break Repair R-HSA-5693532 3.159499e-02 1.500 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 3.341681e-02 1.476 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 3.341681e-02 1.476 0 0
Regulation of CDH1 Function R-HSA-9764561 3.375483e-02 1.472 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.387161e-02 1.470 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.387161e-02 1.470 0 0
Formation of annular gap junctions R-HSA-196025 3.602893e-02 1.443 0 0
Interaction between L1 and Ankyrins R-HSA-445095 3.409389e-02 1.467 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.877570e-02 1.411 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.877570e-02 1.411 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.509499e-02 1.455 0 0
Opioid Signalling R-HSA-111885 3.740475e-02 1.427 0 0
Vesicle-mediated transport R-HSA-5653656 3.659781e-02 1.437 1 0
Response of endothelial cells to shear stress R-HSA-9860931 3.740475e-02 1.427 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.602893e-02 1.443 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.647420e-02 1.438 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.806877e-02 1.419 0 0
Host Interactions of HIV factors R-HSA-162909 4.057258e-02 1.392 0 0
MITF-M-dependent gene expression R-HSA-9856651 4.133891e-02 1.384 0 0
Inositol phosphate metabolism R-HSA-1483249 4.238734e-02 1.373 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.314692e-02 1.365 0 0
Signal amplification R-HSA-392518 4.338862e-02 1.363 0 0
Frs2-mediated activation R-HSA-170968 4.358573e-02 1.361 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.459356e-02 1.351 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 4.459356e-02 1.351 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 4.459356e-02 1.351 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 4.459356e-02 1.351 0 0
TRAF3 deficiency - HSE R-HSA-5602571 4.486744e-02 1.348 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.486744e-02 1.348 0 0
Organelle biogenesis and maintenance R-HSA-1852241 4.511850e-02 1.346 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 4.629626e-02 1.334 0 0
Presynaptic function of Kainate receptors R-HSA-500657 4.629626e-02 1.334 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 4.647495e-02 1.333 0 0
Gap junction degradation R-HSA-190873 4.687901e-02 1.329 0 0
ALK mutants bind TKIs R-HSA-9700645 4.687901e-02 1.329 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 4.687901e-02 1.329 0 0
Unwinding of DNA R-HSA-176974 4.687901e-02 1.329 0 0
Glycolysis R-HSA-70171 4.727401e-02 1.325 0 0
Selective autophagy R-HSA-9663891 4.881392e-02 1.311 0 0
Viral Messenger RNA Synthesis R-HSA-168325 4.969772e-02 1.304 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 5.376603e-02 1.269 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 5.313142e-02 1.275 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 5.313142e-02 1.275 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 5.764321e-02 1.239 0 0
MTOR signalling R-HSA-165159 5.738967e-02 1.241 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 5.904613e-02 1.229 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 5.559176e-02 1.255 0 0
Interleukin-37 signaling R-HSA-9008059 5.170553e-02 1.286 0 0
Josephin domain DUBs R-HSA-5689877 5.934390e-02 1.227 0 0
2-LTR circle formation R-HSA-164843 5.934390e-02 1.227 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 5.934390e-02 1.227 0 0
Semaphorin interactions R-HSA-373755 5.934809e-02 1.227 0 0
MHC class II antigen presentation R-HSA-2132295 6.084683e-02 1.216 0 0
Influenza Infection R-HSA-168255 6.097349e-02 1.215 0 0
HIV Life Cycle R-HSA-162587 6.117745e-02 1.213 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.146197e-02 1.211 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 6.146197e-02 1.211 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.146197e-02 1.211 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 6.146197e-02 1.211 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 6.146197e-02 1.211 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 6.221161e-02 1.206 1 1
Drug resistance in ERBB2 KD mutants R-HSA-9665230 7.424025e-02 1.129 0 0
Regulation of TP53 Expression R-HSA-6804754 7.424025e-02 1.129 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 7.424025e-02 1.129 0 0
Signalling to ERK5 R-HSA-198765 7.424025e-02 1.129 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 7.424025e-02 1.129 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 7.424025e-02 1.129 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 7.424025e-02 1.129 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 7.424025e-02 1.129 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 7.424025e-02 1.129 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 7.424025e-02 1.129 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 7.424025e-02 1.129 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 7.424025e-02 1.129 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 7.424025e-02 1.129 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 7.424025e-02 1.129 0 0
G0 and Early G1 R-HSA-1538133 6.620296e-02 1.179 0 0
G1 Phase R-HSA-69236 7.030290e-02 1.153 0 0
Cyclin D associated events in G1 R-HSA-69231 7.030290e-02 1.153 0 0
Switching of origins to a post-replicative state R-HSA-69052 7.481363e-02 1.126 0 0
G-protein activation R-HSA-202040 7.384677e-02 1.132 0 0
Homology Directed Repair R-HSA-5693538 7.075736e-02 1.150 0 0
Epigenetic regulation of gene expression R-HSA-212165 6.872049e-02 1.163 0 0
Nuclear RNA decay R-HSA-9930044 7.430411e-02 1.129 0 0
G1/S Transition R-HSA-69206 7.257705e-02 1.139 0 0
Circadian clock R-HSA-9909396 7.419052e-02 1.130 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 6.402751e-02 1.194 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 7.424025e-02 1.129 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.380754e-02 1.195 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 6.643972e-02 1.178 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 6.643972e-02 1.178 0 0
Muscle contraction R-HSA-397014 6.967457e-02 1.157 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 7.030290e-02 1.153 0 0
Cytokine Signaling in Immune system R-HSA-1280215 6.372578e-02 1.196 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 7.559207e-02 1.122 0 0
Unfolded Protein Response (UPR) R-HSA-381119 7.561827e-02 1.121 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 7.698613e-02 1.114 0 0
Cell junction organization R-HSA-446728 7.724718e-02 1.112 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.883050e-02 1.103 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 7.972127e-02 1.098 0 0
DNA Repair R-HSA-73894 8.083448e-02 1.092 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 8.084491e-02 1.092 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 8.084491e-02 1.092 0 0
Autointegration results in viral DNA circles R-HSA-177539 8.084491e-02 1.092 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 8.084491e-02 1.092 0 0
ER to Golgi Anterograde Transport R-HSA-199977 8.093600e-02 1.092 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 8.198552e-02 1.086 0 0
Macroautophagy R-HSA-1632852 8.399935e-02 1.076 0 0
Meiotic synapsis R-HSA-1221632 8.451819e-02 1.073 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 8.472831e-02 1.072 0 0
G2/M Transition R-HSA-69275 8.493443e-02 1.071 0 0
Autophagy R-HSA-9612973 8.611993e-02 1.065 0 0
Disorders of Developmental Biology R-HSA-9675151 8.846979e-02 1.053 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 8.846979e-02 1.053 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 8.846979e-02 1.053 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 8.846979e-02 1.053 0 0
Activation of RAC1 R-HSA-428540 8.896261e-02 1.051 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 8.896261e-02 1.051 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 8.896261e-02 1.051 0 0
Mitotic G2-G2/M phases R-HSA-453274 9.281122e-02 1.032 0 0
Interleukin-12 signaling R-HSA-9020591 9.309427e-02 1.031 0 0
Deletions in the AXIN1 gene destabilize the destruction complex R-HSA-5467345 1.054848e-01 0.977 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.054848e-01 0.977 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.054848e-01 0.977 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.054848e-01 0.977 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.054848e-01 0.977 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.080450e-01 0.966 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.080450e-01 0.966 0 0
Regulation of PTEN localization R-HSA-8948747 1.025056e-01 0.989 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.025056e-01 0.989 0 0
Disorders of Nervous System Development R-HSA-9697154 1.059788e-01 0.975 0 0
Pervasive developmental disorders R-HSA-9005895 1.059788e-01 0.975 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.059788e-01 0.975 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.173660e-01 0.930 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.004341e-01 0.998 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.004341e-01 0.998 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.012428e-01 0.995 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.066990e-01 0.972 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.171518e-01 0.931 0 0
Clathrin-mediated endocytosis R-HSA-8856828 9.769582e-02 1.010 1 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.173660e-01 0.930 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.059788e-01 0.975 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.089760e-01 0.963 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.026755e-01 0.989 0 0
Cilium Assembly R-HSA-5617833 1.011593e-01 0.995 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.020321e-01 0.991 0 0
Platelet sensitization by LDL R-HSA-432142 1.173660e-01 0.930 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.080450e-01 0.966 0 0
rRNA processing R-HSA-72312 1.137393e-01 0.944 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.049846e-01 0.979 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.021256e-01 0.991 0 0
Uptake and function of anthrax toxins R-HSA-5210891 1.024087e-01 0.990 0 0
Cell-Cell communication R-HSA-1500931 9.486241e-02 1.023 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.059788e-01 0.975 0 0
NGF-stimulated transcription R-HSA-9031628 1.012428e-01 0.995 0 0
Estrogen-dependent gene expression R-HSA-9018519 9.662888e-02 1.015 0 0
NRAGE signals death through JNK R-HSA-193648 1.078822e-01 0.967 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.177695e-01 0.929 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.177695e-01 0.929 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.190072e-01 0.924 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 1.222974e-01 0.913 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.233192e-01 0.909 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.237945e-01 0.907 0 0
Synthesis of DNA R-HSA-69239 1.238664e-01 0.907 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.243426e-01 0.905 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.243426e-01 0.905 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.253410e-01 0.902 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.258009e-01 0.900 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.261785e-01 0.899 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.261785e-01 0.899 0 0
Adrenoceptors R-HSA-390696 1.261785e-01 0.899 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.261785e-01 0.899 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.292241e-01 0.889 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.302140e-01 0.885 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.321099e-01 0.879 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 1.332898e-01 0.875 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.347715e-01 0.870 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.363772e-01 0.865 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.418344e-01 0.848 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 1.439432e-01 0.842 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.442640e-01 0.841 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.450209e-01 0.839 0 0
Regulation of gap junction activity R-HSA-191650 1.450209e-01 0.839 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 1.450209e-01 0.839 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 1.450209e-01 0.839 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 1.450209e-01 0.839 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.450209e-01 0.839 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 1.450209e-01 0.839 0 0
Regulation of TP53 Activity R-HSA-5633007 1.468389e-01 0.833 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.998481e-01 0.699 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.998481e-01 0.699 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 1.998481e-01 0.699 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.998481e-01 0.699 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 1.998481e-01 0.699 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 1.998481e-01 0.699 0 0
Defective F8 binding to von Willebrand factor R-HSA-9672393 1.998481e-01 0.699 0 0
TGFBR2 MSI Frameshift Mutants in Cancer R-HSA-3642279 1.998481e-01 0.699 0 0
Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) R-HSA-5619045 2.842619e-01 0.546 0 0
Defective SLC34A2 causes PALM R-HSA-5687583 2.842619e-01 0.546 0 0
Defective SLC9A9 causes autism 16 (AUTS16) R-HSA-5619052 2.842619e-01 0.546 0 0
Defective VWF binding to collagen type I R-HSA-9845622 2.842619e-01 0.546 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.842619e-01 0.546 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 2.842619e-01 0.546 0 0
XAV939 stabilizes AXIN R-HSA-5545619 2.842619e-01 0.546 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.842619e-01 0.546 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.842619e-01 0.546 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 2.842619e-01 0.546 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 2.842619e-01 0.546 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.842619e-01 0.546 0 0
IRS activation R-HSA-74713 1.841237e-01 0.735 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.841237e-01 0.735 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 1.841237e-01 0.735 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 1.841237e-01 0.735 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 1.841237e-01 0.735 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 1.515834e-01 0.819 0 0
ARMS-mediated activation R-HSA-170984 1.515834e-01 0.819 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 2.244939e-01 0.649 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 2.244939e-01 0.649 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 2.244939e-01 0.649 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 2.244939e-01 0.649 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.597746e-01 0.444 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.597746e-01 0.444 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.597746e-01 0.444 0 0
Potassium transport channels R-HSA-1296067 3.597746e-01 0.444 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.597746e-01 0.444 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.597746e-01 0.444 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 3.597746e-01 0.444 0 0
Defective F8 cleavage by thrombin R-HSA-9672391 3.597746e-01 0.444 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.597746e-01 0.444 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 3.597746e-01 0.444 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.597746e-01 0.444 0 0
Binding and entry of HIV virion R-HSA-173107 1.784362e-01 0.749 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.784362e-01 0.749 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.064572e-01 0.685 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.863637e-01 0.730 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 1.863637e-01 0.730 0 0
Phosphorylation of the APC/C R-HSA-176412 1.863637e-01 0.730 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.863637e-01 0.730 0 0
ERKs are inactivated R-HSA-202670 2.353769e-01 0.628 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.063622e-01 0.514 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.063622e-01 0.514 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.063622e-01 0.514 0 0
SOS-mediated signalling R-HSA-112412 3.063622e-01 0.514 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.273245e-01 0.369 0 0
Defective DPM1 causes DPM1-CDG R-HSA-4717374 4.273245e-01 0.369 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.273245e-01 0.369 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.273245e-01 0.369 0 0
Defective ABCD4 causes MAHCJ R-HSA-5683329 4.273245e-01 0.369 0 0
Defective DPM3 causes DPM3-CDG R-HSA-4719360 4.273245e-01 0.369 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 4.273245e-01 0.369 0 0
Defective DPM2 causes DPM2-CDG R-HSA-4719377 4.273245e-01 0.369 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.649408e-01 0.577 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.862270e-01 0.730 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.862270e-01 0.730 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.862270e-01 0.730 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 1.666604e-01 0.778 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 2.322065e-01 0.634 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.322065e-01 0.634 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 2.322065e-01 0.634 0 0
Type I hemidesmosome assembly R-HSA-446107 3.468375e-01 0.460 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 3.468375e-01 0.460 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.949119e-01 0.530 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 2.949119e-01 0.530 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.634646e-01 0.787 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.560791e-01 0.592 0 0
Late endosomal microautophagy R-HSA-9615710 1.994802e-01 0.700 0 0
Dual Incision in GG-NER R-HSA-5696400 1.778170e-01 0.750 0 0
Deadenylation of mRNA R-HSA-429947 2.453706e-01 0.610 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.804118e-01 0.552 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.804118e-01 0.552 0 0
Lipophagy R-HSA-9613354 3.864966e-01 0.413 0 0
WNT mediated activation of DVL R-HSA-201688 3.864966e-01 0.413 0 0
Hypusine synthesis from eIF5A-lysine R-HSA-204626 3.864966e-01 0.413 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.877508e-01 0.312 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.877508e-01 0.312 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.877508e-01 0.312 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.877508e-01 0.312 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 4.877508e-01 0.312 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 4.877508e-01 0.312 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.877508e-01 0.312 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.877508e-01 0.312 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 2.660946e-01 0.575 0 0
G protein gated Potassium channels R-HSA-1296059 2.660946e-01 0.575 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 2.660946e-01 0.575 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 2.660946e-01 0.575 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 3.050787e-01 0.516 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 3.050787e-01 0.516 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.050787e-01 0.516 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.050787e-01 0.516 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.050787e-01 0.516 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.050787e-01 0.516 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.050787e-01 0.516 0 0
DCC mediated attractive signaling R-HSA-418885 3.552262e-01 0.449 0 0
Spry regulation of FGF signaling R-HSA-1295596 3.552262e-01 0.449 0 0
Erythropoietin activates RAS R-HSA-9027284 3.552262e-01 0.449 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 3.552262e-01 0.449 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 3.299595e-01 0.482 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 4.250614e-01 0.372 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.250614e-01 0.372 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 4.250614e-01 0.372 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.085711e-01 0.511 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.085711e-01 0.511 0 0
Telomere Extension By Telomerase R-HSA-171319 3.301657e-01 0.481 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 3.301657e-01 0.481 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 4.148275e-01 0.382 0 0
PECAM1 interactions R-HSA-210990 4.623213e-01 0.335 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 4.623213e-01 0.335 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 5.418044e-01 0.266 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 5.418044e-01 0.266 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 5.418044e-01 0.266 0 0
Defective F9 activation R-HSA-9673221 5.418044e-01 0.266 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.418044e-01 0.266 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.281876e-01 0.642 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.281876e-01 0.642 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.669117e-01 0.574 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 4.439839e-01 0.353 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 4.439839e-01 0.353 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 2.596988e-01 0.586 0 0
Orc1 removal from chromatin R-HSA-68949 3.548497e-01 0.450 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 4.981225e-01 0.303 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 4.981225e-01 0.303 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.981225e-01 0.303 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.489175e-01 0.457 0 0
Ephrin signaling R-HSA-3928664 4.725491e-01 0.326 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 3.968144e-01 0.401 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 4.538450e-01 0.343 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 3.396289e-01 0.469 0 0
Recycling pathway of L1 R-HSA-437239 4.147399e-01 0.382 0 0
Neutrophil degranulation R-HSA-6798695 1.919999e-01 0.717 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 5.004243e-01 0.301 0 0
Regulation of signaling by CBL R-HSA-912631 5.004243e-01 0.301 0 0
Repression of WNT target genes R-HSA-4641265 5.323581e-01 0.274 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 5.901569e-01 0.229 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 5.901569e-01 0.229 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 5.901569e-01 0.229 0 0
Plus-strand DNA synthesis R-HSA-164525 5.901569e-01 0.229 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 5.901569e-01 0.229 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.901569e-01 0.229 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 5.901569e-01 0.229 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.901569e-01 0.229 0 0
Signaling by RNF43 mutants R-HSA-5340588 5.901569e-01 0.229 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 4.813163e-01 0.318 0 0
Cristae formation R-HSA-8949613 5.014975e-01 0.300 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.383294e-01 0.358 0 0
Activation of GABAB receptors R-HSA-991365 4.837864e-01 0.315 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 5.246336e-01 0.280 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 5.030750e-01 0.298 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 5.537923e-01 0.257 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 5.537923e-01 0.257 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 5.202646e-01 0.284 0 0
Signaling by Erythropoietin R-HSA-9006335 5.472390e-01 0.262 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.472390e-01 0.262 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 5.577016e-01 0.254 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 5.791660e-01 0.237 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.703990e-01 0.244 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 5.754052e-01 0.240 0 0
Chromosome Maintenance R-HSA-73886 4.368924e-01 0.360 0 0
Extension of Telomeres R-HSA-180786 3.335573e-01 0.477 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.581180e-01 0.588 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 3.078796e-01 0.512 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.011292e-01 0.697 0 0
IRE1alpha activates chaperones R-HSA-381070 1.647416e-01 0.783 0 0
Formation of definitive endoderm R-HSA-9823730 1.501199e-01 0.824 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 3.791182e-01 0.421 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 5.692701e-01 0.245 0 0
HCMV Early Events R-HSA-9609690 2.287897e-01 0.641 0 0
MET promotes cell motility R-HSA-8875878 5.625839e-01 0.250 0 0
EPH-Ephrin signaling R-HSA-2682334 3.521553e-01 0.453 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 1.752579e-01 0.756 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.733752e-01 0.563 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 4.439839e-01 0.353 0 0
Nucleotide Excision Repair R-HSA-5696398 1.667554e-01 0.778 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.735307e-01 0.761 0 0
GABA B receptor activation R-HSA-977444 4.837864e-01 0.315 0 0
Regulation of KIT signaling R-HSA-1433559 3.250726e-01 0.488 0 0
Extrinsic Pathway of Fibrin Clot Formation R-HSA-140834 4.877508e-01 0.312 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.007322e-01 0.697 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 4.017082e-01 0.396 0 0
Signaling by SCF-KIT R-HSA-1433557 5.026731e-01 0.299 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 4.148275e-01 0.382 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 4.981225e-01 0.303 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.501199e-01 0.824 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.799143e-01 0.420 0 0
PTEN Regulation R-HSA-6807070 4.735877e-01 0.325 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.692701e-01 0.245 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.609854e-01 0.443 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.646595e-01 0.783 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 3.672952e-01 0.435 0 0
Integrin signaling R-HSA-354192 4.387746e-01 0.358 0 0
Assembly of the pre-replicative complex R-HSA-68867 2.646127e-01 0.577 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 2.216402e-01 0.654 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 4.148275e-01 0.382 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.961612e-01 0.707 0 0
Regulation of CDH11 function R-HSA-9762292 1.784362e-01 0.749 0 0
G-protein beta:gamma signalling R-HSA-397795 1.496570e-01 0.825 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 3.864966e-01 0.413 0 0
PI3K/AKT activation R-HSA-198203 4.250614e-01 0.372 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 4.439839e-01 0.353 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 4.981225e-01 0.303 0 0
Peptide chain elongation R-HSA-156902 3.983036e-01 0.400 0 0
Co-inhibition by CTLA4 R-HSA-389513 5.275276e-01 0.278 0 0
Fanconi Anemia Pathway R-HSA-6783310 5.396607e-01 0.268 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.196336e-01 0.658 0 0
Adipogenesis R-HSA-9843745 5.716617e-01 0.243 0 0
Myogenesis R-HSA-525793 1.511786e-01 0.821 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.883197e-01 0.540 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.649408e-01 0.577 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 5.396607e-01 0.268 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.549403e-01 0.450 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.176518e-01 0.662 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 1.677897e-01 0.775 0 0
Formation of axial mesoderm R-HSA-9796292 2.949119e-01 0.530 0 0
E2F mediated regulation of DNA replication R-HSA-113510 2.804118e-01 0.552 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 2.080211e-01 0.682 0 0
Negative regulation of MET activity R-HSA-6807004 3.050787e-01 0.516 0 0
Telomere C-strand synthesis initiation R-HSA-174430 3.552262e-01 0.449 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 5.418044e-01 0.266 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.323581e-01 0.274 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 4.069973e-01 0.390 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 5.372306e-01 0.270 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 5.781628e-01 0.238 0 0
Signaling by FGFR1 in disease R-HSA-5655302 4.646825e-01 0.333 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 4.171921e-01 0.380 0 0
Signaling by WNT R-HSA-195721 3.549587e-01 0.450 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 2.871881e-01 0.542 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.304170e-01 0.275 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.905098e-01 0.537 0 0
Germ layer formation at gastrulation R-HSA-9754189 5.004243e-01 0.301 0 0
PIP3 activates AKT signaling R-HSA-1257604 5.308103e-01 0.275 0 0
Long-term potentiation R-HSA-9620244 2.660946e-01 0.575 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.714077e-01 0.766 0 0
ERK/MAPK targets R-HSA-198753 3.299595e-01 0.482 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.905098e-01 0.537 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.323581e-01 0.274 0 0
Gap junction trafficking and regulation R-HSA-157858 3.058274e-01 0.515 0 0
DNA Double Strand Break Response R-HSA-5693606 3.287655e-01 0.483 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 3.799018e-01 0.420 0 0
G alpha (z) signalling events R-HSA-418597 5.539494e-01 0.257 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 5.188085e-01 0.285 0 0
L1CAM interactions R-HSA-373760 2.087859e-01 0.680 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.912143e-01 0.718 0 0
G-protein mediated events R-HSA-112040 4.577215e-01 0.339 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 2.136335e-01 0.670 0 0
Protein folding R-HSA-391251 2.535437e-01 0.596 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 3.453863e-01 0.462 0 0
Proteasome assembly R-HSA-9907900 5.213083e-01 0.283 0 0
Intracellular signaling by second messengers R-HSA-9006925 3.578256e-01 0.446 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 2.353769e-01 0.628 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 1.511786e-01 0.821 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.322065e-01 0.634 0 0
Transport of connexons to the plasma membrane R-HSA-190872 2.560791e-01 0.592 0 0
Calcineurin activates NFAT R-HSA-2025928 3.864966e-01 0.413 0 0
DNA strand elongation R-HSA-69190 2.525842e-01 0.598 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 3.299595e-01 0.482 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 4.250614e-01 0.372 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 2.899329e-01 0.538 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.209938e-01 0.656 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 3.090231e-01 0.510 0 0
DARPP-32 events R-HSA-180024 3.518959e-01 0.454 0 0
Formation of the posterior neural plate R-HSA-9832991 4.623213e-01 0.335 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.418044e-01 0.266 0 0
PTK6 Down-Regulation R-HSA-8849472 5.418044e-01 0.266 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 5.275276e-01 0.278 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 5.865596e-01 0.232 0 0
Gap junction trafficking R-HSA-190828 3.609854e-01 0.443 0 0
DNA Replication R-HSA-69306 4.450123e-01 0.352 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.799143e-01 0.420 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.711012e-01 0.567 0 0
Signal transduction by L1 R-HSA-445144 5.275276e-01 0.278 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.649408e-01 0.577 0 0
Meiosis R-HSA-1500620 2.439296e-01 0.613 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 3.548497e-01 0.450 0 0
Acyl chain remodelling of PS R-HSA-1482801 4.538450e-01 0.343 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 5.202646e-01 0.284 0 0
Platelet calcium homeostasis R-HSA-418360 5.472390e-01 0.262 0 0
HCMV Infection R-HSA-9609646 5.319802e-01 0.274 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.778818e-01 0.321 0 0
Apoptotic factor-mediated response R-HSA-111471 4.725491e-01 0.326 0 0
Inhibition of nitric oxide production R-HSA-9636249 4.273245e-01 0.369 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.877508e-01 0.312 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.877508e-01 0.312 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.565178e-01 0.591 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.418044e-01 0.266 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.901569e-01 0.229 0 0
Axon guidance R-HSA-422475 2.038346e-01 0.691 0 0
Gene expression (Transcription) R-HSA-74160 3.928452e-01 0.406 0 0
PLC beta mediated events R-HSA-112043 3.643743e-01 0.438 0 0
Ca2+ pathway R-HSA-4086398 2.971716e-01 0.527 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 3.851963e-01 0.414 0 0
Signaling by TGFB family members R-HSA-9006936 5.160410e-01 0.287 0 0
Nervous system development R-HSA-9675108 2.151066e-01 0.667 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 3.254430e-01 0.488 0 0
Signaling by NODAL R-HSA-1181150 5.275276e-01 0.278 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 1.841237e-01 0.735 0 0
Inwardly rectifying K+ channels R-HSA-1296065 2.525842e-01 0.598 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 5.419195e-01 0.266 0 0
Signaling by ROBO receptors R-HSA-376176 2.809544e-01 0.551 0 0
Signalling to ERKs R-HSA-187687 1.926809e-01 0.715 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 2.905098e-01 0.537 0 0
Protein methylation R-HSA-8876725 1.646595e-01 0.783 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.778170e-01 0.750 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 2.167183e-01 0.664 0 0
MAPK family signaling cascades R-HSA-5683057 3.916378e-01 0.407 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 3.090231e-01 0.510 0 0
PERK regulates gene expression R-HSA-381042 3.283163e-01 0.484 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 5.004243e-01 0.301 0 0
Signaling by EGFR R-HSA-177929 2.883197e-01 0.540 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.477581e-01 0.459 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.308911e-01 0.637 0 0
Mismatch Repair R-HSA-5358508 4.725491e-01 0.326 0 0
Ion homeostasis R-HSA-5578775 5.703990e-01 0.244 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.666604e-01 0.778 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 3.585200e-01 0.445 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.683843e-01 0.434 0 0
Ca-dependent events R-HSA-111996 3.254430e-01 0.488 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.968144e-01 0.401 0 0
Inhibition of PKR R-HSA-169131 1.998481e-01 0.699 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.842619e-01 0.546 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.842619e-01 0.546 0 0
Manipulation of host energy metabolism R-HSA-9636667 2.842619e-01 0.546 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.842619e-01 0.546 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 2.244939e-01 0.649 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 3.597746e-01 0.444 0 0
Interleukin-33 signaling R-HSA-9014843 3.597746e-01 0.444 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 2.654294e-01 0.576 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 1.863637e-01 0.730 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.273245e-01 0.369 0 0
MET interacts with TNS proteins R-HSA-8875513 4.273245e-01 0.369 0 0
Type II Na+/Pi cotransporters R-HSA-427589 4.273245e-01 0.369 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.089238e-01 0.680 0 0
Regulation of IFNG signaling R-HSA-877312 2.649408e-01 0.577 0 0
Sodium/Proton exchangers R-HSA-425986 3.468375e-01 0.460 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 2.250973e-01 0.648 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.778170e-01 0.750 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 3.864966e-01 0.413 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 3.864966e-01 0.413 0 0
DNA replication initiation R-HSA-68952 4.250614e-01 0.372 0 0
DAG and IP3 signaling R-HSA-1489509 2.431970e-01 0.614 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 3.851963e-01 0.414 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 3.851963e-01 0.414 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.418044e-01 0.266 0 0
HIV Infection R-HSA-162906 2.190849e-01 0.659 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 4.147399e-01 0.382 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 4.326239e-01 0.364 0 0
Pentose phosphate pathway disease R-HSA-6791465 5.901569e-01 0.229 0 0
Synthesis of dolichyl-phosphate mannose R-HSA-162699 5.901569e-01 0.229 0 0
Threonine catabolism R-HSA-8849175 5.901569e-01 0.229 0 0
Synthesis of PS R-HSA-1483101 5.901569e-01 0.229 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 5.901569e-01 0.229 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 4.813163e-01 0.318 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 5.649598e-01 0.248 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 5.791660e-01 0.237 0 0
Deubiquitination R-HSA-5688426 4.994627e-01 0.301 0 0
Post NMDA receptor activation events R-HSA-438064 3.849947e-01 0.415 0 0
Rab regulation of trafficking R-HSA-9007101 2.176220e-01 0.662 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.194539e-01 0.284 0 0
Platelet homeostasis R-HSA-418346 3.402991e-01 0.468 0 0
TNF signaling R-HSA-75893 5.703990e-01 0.244 0 0
Calmodulin induced events R-HSA-111933 3.477581e-01 0.459 0 0
Signaling by VEGF R-HSA-194138 4.939853e-01 0.306 0 0
Neurexins and neuroligins R-HSA-6794361 2.309514e-01 0.636 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 4.794756e-01 0.319 0 0
CaM pathway R-HSA-111997 3.477581e-01 0.459 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 5.537923e-01 0.257 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.294536e-01 0.367 0 0
Adherens junctions interactions R-HSA-418990 1.647330e-01 0.783 0 0
Cell-cell junction organization R-HSA-421270 2.667060e-01 0.574 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.741318e-01 0.759 0 0
Mitochondrial biogenesis R-HSA-1592230 1.527064e-01 0.816 0 0
Termination of translesion DNA synthesis R-HSA-5656169 5.472390e-01 0.262 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.518959e-01 0.454 0 0
Diseases of programmed cell death R-HSA-9645723 3.983036e-01 0.400 0 0
Suppression of apoptosis R-HSA-9635465 2.064572e-01 0.685 0 0
Rap1 signalling R-HSA-392517 2.804118e-01 0.552 0 0
Signal attenuation R-HSA-74749 4.250614e-01 0.372 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.324646e-01 0.634 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.736893e-01 0.427 0 0
TBC/RABGAPs R-HSA-8854214 5.026731e-01 0.299 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.901798e-01 0.721 0 0
FLT3 Signaling R-HSA-9607240 2.905098e-01 0.537 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 4.250614e-01 0.372 0 0
Negative regulation of FLT3 R-HSA-9706369 3.851963e-01 0.414 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 4.981225e-01 0.303 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 5.396607e-01 0.268 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.954742e-01 0.403 0 0
Signaling by PTK6 R-HSA-8848021 3.954742e-01 0.403 0 0
ESR-mediated signaling R-HSA-8939211 2.295860e-01 0.639 0 0
Protein ubiquitination R-HSA-8852135 2.216402e-01 0.654 0 0
FLT3 signaling in disease R-HSA-9682385 5.226972e-01 0.282 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.877508e-01 0.312 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 3.552262e-01 0.449 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.418044e-01 0.266 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 3.788837e-01 0.421 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.518959e-01 0.454 0 0
The NLRP3 inflammasome R-HSA-844456 5.004243e-01 0.301 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 4.212947e-01 0.375 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 3.063622e-01 0.514 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 3.736893e-01 0.427 0 0
Activation of BH3-only proteins R-HSA-114452 3.736893e-01 0.427 0 0
RMTs methylate histone arginines R-HSA-3214858 3.609854e-01 0.443 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 4.387746e-01 0.358 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 5.226972e-01 0.282 0 0
DNA Damage Bypass R-HSA-73893 1.910208e-01 0.719 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 5.537923e-01 0.257 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 4.977289e-01 0.303 0 0
Late Phase of HIV Life Cycle R-HSA-162599 4.222548e-01 0.374 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 4.837864e-01 0.315 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.842619e-01 0.546 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.244939e-01 0.649 0 0
DSCAM interactions R-HSA-376172 3.597746e-01 0.444 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.273245e-01 0.369 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.089238e-01 0.680 0 0
Maturation of nucleoprotein R-HSA-9683610 2.949119e-01 0.530 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.864966e-01 0.413 0 0
NADE modulates death signalling R-HSA-205025 4.877508e-01 0.312 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 2.711012e-01 0.567 0 0
Regulation of the apoptosome activity R-HSA-9627069 4.250614e-01 0.372 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.851963e-01 0.414 0 0
Interleukin-36 pathway R-HSA-9014826 5.418044e-01 0.266 0 0
Hydroxycarboxylic acid-binding receptors R-HSA-3296197 5.418044e-01 0.266 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.453863e-01 0.462 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 3.880217e-01 0.411 0 0
Regulation of necroptotic cell death R-HSA-5675482 4.387746e-01 0.358 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 5.323581e-01 0.274 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.350648e-01 0.475 0 0
Death Receptor Signaling R-HSA-73887 4.552207e-01 0.342 0 0
Basigin interactions R-HSA-210991 1.677897e-01 0.775 0 0
Formation of apoptosome R-HSA-111458 4.250614e-01 0.372 0 0
Gene Silencing by RNA R-HSA-211000 1.833495e-01 0.737 0 0
Protein hydroxylation R-HSA-9629569 5.275276e-01 0.278 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 5.692701e-01 0.245 0 0
Other interleukin signaling R-HSA-449836 5.004243e-01 0.301 0 0
RET signaling R-HSA-8853659 3.477581e-01 0.459 0 0
Neurofascin interactions R-HSA-447043 2.654294e-01 0.576 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.646595e-01 0.783 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 4.387746e-01 0.358 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 5.246336e-01 0.280 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 5.625839e-01 0.250 0 0
Cytoprotection by HMOX1 R-HSA-9707564 5.603217e-01 0.252 0 0
Signaling by NTRKs R-HSA-166520 1.735447e-01 0.761 0 0
Response of Mtb to phagocytosis R-HSA-9637690 5.026731e-01 0.299 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.250614e-01 0.372 0 0
Glucose metabolism R-HSA-70326 1.527064e-01 0.816 0 0
Bicarbonate transporters R-HSA-425381 4.623213e-01 0.335 0 0
G1/S-Specific Transcription R-HSA-69205 3.477581e-01 0.459 0 0
Relaxin receptors R-HSA-444821 5.901569e-01 0.229 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 5.901569e-01 0.229 0 0
Ribavirin ADME R-HSA-9755088 5.791660e-01 0.237 0 0
tRNA processing R-HSA-72306 2.211922e-01 0.655 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 5.037191e-01 0.298 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 5.815806e-01 0.235 0 0
ChREBP activates metabolic gene expression R-HSA-163765 2.064572e-01 0.685 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 5.692701e-01 0.245 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.855647e-01 0.732 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.864966e-01 0.413 0 0
Maturation of nucleoprotein R-HSA-9694631 5.004243e-01 0.301 0 0
Diseases of DNA repair R-HSA-9675135 2.584642e-01 0.588 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 3.063622e-01 0.514 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.864966e-01 0.413 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 3.552262e-01 0.449 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 3.552262e-01 0.449 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.549403e-01 0.450 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 5.418044e-01 0.266 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 4.540376e-01 0.343 0 0
Interleukin-7 signaling R-HSA-1266695 4.538450e-01 0.343 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 3.085711e-01 0.511 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.749514e-01 0.757 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.560791e-01 0.592 0 0
Growth hormone receptor signaling R-HSA-982772 4.047824e-01 0.393 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 3.340276e-01 0.476 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 1.827771e-01 0.738 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.549403e-01 0.450 0 0
CD28 dependent Vav1 pathway R-HSA-389359 5.649598e-01 0.248 0 0
Signaling by Leptin R-HSA-2586552 1.784362e-01 0.749 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 5.030750e-01 0.298 0 0
Signaling by Interleukins R-HSA-449147 3.758970e-01 0.425 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 5.710937e-01 0.243 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 3.864966e-01 0.413 0 0
Glucagon-type ligand receptors R-HSA-420092 3.518959e-01 0.454 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.418044e-01 0.266 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.299595e-01 0.482 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 3.090231e-01 0.510 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 5.818820e-01 0.235 0 0
STING mediated induction of host immune responses R-HSA-1834941 5.004243e-01 0.301 0 0
SARS-CoV-2 Infection R-HSA-9694516 4.669177e-01 0.331 0 0
SARS-CoV-1 Infection R-HSA-9678108 4.117042e-01 0.385 0 0
Interleukin-12 family signaling R-HSA-447115 1.912143e-01 0.718 0 0
EGFR downregulation R-HSA-182971 5.906903e-01 0.229 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 5.906903e-01 0.229 0 0
GPER1 signaling R-HSA-9634597 5.927486e-01 0.227 0 0
Intraflagellar transport R-HSA-5620924 5.927486e-01 0.227 0 0
Co-stimulation by CD28 R-HSA-389356 5.927486e-01 0.227 0 0
Selenocysteine synthesis R-HSA-2408557 5.931318e-01 0.227 0 0
Physiological factors R-HSA-5578768 5.958913e-01 0.225 0 0
Signal regulatory protein family interactions R-HSA-391160 5.958913e-01 0.225 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 6.007127e-01 0.221 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 6.007127e-01 0.221 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 6.007127e-01 0.221 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 6.007127e-01 0.221 0 0
Diseases of Immune System R-HSA-5260271 6.007127e-01 0.221 0 0
Generation of second messenger molecules R-HSA-202433 6.007127e-01 0.221 0 0
MyD88-independent TLR4 cascade R-HSA-166166 6.016572e-01 0.221 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 6.016572e-01 0.221 0 0
Dual incision in TC-NER R-HSA-6782135 6.024134e-01 0.220 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 6.036090e-01 0.219 0 0
Notch-HLH transcription pathway R-HSA-350054 6.036090e-01 0.219 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 6.036090e-01 0.219 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 6.052270e-01 0.218 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 6.052270e-01 0.218 0 0
Degradation of CDH1 R-HSA-9766229 6.097114e-01 0.215 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 6.111859e-01 0.214 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 6.182003e-01 0.209 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 6.190534e-01 0.208 0 0
RAF/MAP kinase cascade R-HSA-5673001 6.216063e-01 0.206 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 6.216435e-01 0.206 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.251420e-01 0.204 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 6.251420e-01 0.204 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 6.251420e-01 0.204 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.251420e-01 0.204 0 0
Biotin transport and metabolism R-HSA-196780 6.251420e-01 0.204 0 0
Formation of the anterior neural plate R-HSA-9823739 6.251420e-01 0.204 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 6.270930e-01 0.203 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 6.270930e-01 0.203 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 6.315838e-01 0.200 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 6.315838e-01 0.200 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 6.315838e-01 0.200 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 6.315838e-01 0.200 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 6.315838e-01 0.200 0 0
Signaling by ERBB2 R-HSA-1227986 6.331381e-01 0.199 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.334094e-01 0.198 0 0
Signaling by LTK in cancer R-HSA-9842640 6.334094e-01 0.198 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.334094e-01 0.198 0 0
STAT5 Activation R-HSA-9645135 6.334094e-01 0.198 0 0
Uncoating of the HIV Virion R-HSA-162585 6.334094e-01 0.198 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.334094e-01 0.198 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 6.334094e-01 0.198 0 0
Defective factor VIII causes hemophilia A R-HSA-9662001 6.334094e-01 0.198 0 0
Metabolism of vitamin K R-HSA-6806664 6.334094e-01 0.198 0 0
HDL clearance R-HSA-8964011 6.334094e-01 0.198 0 0
Nef and signal transduction R-HSA-164944 6.334094e-01 0.198 0 0
Eukaryotic Translation Termination R-HSA-72764 6.338169e-01 0.198 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 6.368735e-01 0.196 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 6.396659e-01 0.194 0 0
COPII-mediated vesicle transport R-HSA-204005 6.396659e-01 0.194 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 6.439201e-01 0.191 0 0
Signaling by MET R-HSA-6806834 6.458892e-01 0.190 0 0
MAP kinase activation R-HSA-450294 6.479825e-01 0.188 0 0
Aquaporin-mediated transport R-HSA-445717 6.479825e-01 0.188 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 6.495999e-01 0.187 0 0
Resolution of D-Loop Structures R-HSA-5693537 6.510149e-01 0.186 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 6.510149e-01 0.186 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 6.510149e-01 0.186 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 6.510149e-01 0.186 0 0
Miscellaneous transport and binding events R-HSA-5223345 6.510149e-01 0.186 0 0
Activation of SMO R-HSA-5635838 6.527221e-01 0.185 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.527221e-01 0.185 0 0
Telomere Maintenance R-HSA-157579 6.575348e-01 0.182 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 6.581510e-01 0.182 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 6.581510e-01 0.182 0 0
Reproduction R-HSA-1474165 6.584952e-01 0.181 0 0
Base Excision Repair R-HSA-73884 6.640089e-01 0.178 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 6.669335e-01 0.176 0 0
Post-translational protein phosphorylation R-HSA-8957275 6.690662e-01 0.175 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 6.697499e-01 0.174 0 0
Gap junction assembly R-HSA-190861 6.697499e-01 0.174 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 6.697499e-01 0.174 0 0
SLC transporter disorders R-HSA-5619102 6.705161e-01 0.174 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 6.707374e-01 0.173 0 0
TGFBR3 expression R-HSA-9839394 6.711206e-01 0.173 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.720996e-01 0.173 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.720996e-01 0.173 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.720996e-01 0.173 0 0
FGFR3b ligand binding and activation R-HSA-190371 6.720996e-01 0.173 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.720996e-01 0.173 0 0
Recycling of eIF2:GDP R-HSA-72731 6.720996e-01 0.173 0 0
Netrin mediated repulsion signals R-HSA-418886 6.720996e-01 0.173 0 0
PTK6 Expression R-HSA-8849473 6.720996e-01 0.173 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.720996e-01 0.173 0 0
Opsins R-HSA-419771 6.720996e-01 0.173 0 0
Disinhibition of SNARE formation R-HSA-114516 6.720996e-01 0.173 0 0
Reuptake of GABA R-HSA-888593 6.720996e-01 0.173 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.720996e-01 0.173 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 6.720996e-01 0.173 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.720996e-01 0.173 0 0
CHL1 interactions R-HSA-447041 6.720996e-01 0.173 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.720996e-01 0.173 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 6.734386e-01 0.172 0 0
Cellular response to starvation R-HSA-9711097 6.743527e-01 0.171 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 6.765824e-01 0.170 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 6.786584e-01 0.168 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.786584e-01 0.168 0 0
tRNA modification in the mitochondrion R-HSA-6787450 6.786584e-01 0.168 0 0
Synthesis of PG R-HSA-1483148 6.786584e-01 0.168 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 6.786584e-01 0.168 0 0
FOXO-mediated transcription R-HSA-9614085 6.803715e-01 0.167 0 0
Antigen processing-Cross presentation R-HSA-1236975 6.847398e-01 0.164 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 6.871877e-01 0.163 0 0
Oncogene Induced Senescence R-HSA-2559585 6.877804e-01 0.163 0 0
Signaling by EGFR in Cancer R-HSA-1643713 6.916540e-01 0.160 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 6.916540e-01 0.160 0 0
TRP channels R-HSA-3295583 6.916540e-01 0.160 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 6.916540e-01 0.160 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 6.929227e-01 0.159 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 7.026724e-01 0.153 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 7.028611e-01 0.153 0 0
Nucleosome assembly R-HSA-774815 7.028611e-01 0.153 0 0
Somitogenesis R-HSA-9824272 7.028611e-01 0.153 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 7.029907e-01 0.153 0 0
Specification of primordial germ cells R-HSA-9827857 7.029907e-01 0.153 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 7.051028e-01 0.152 0 0
PRC2 methylates histones and DNA R-HSA-212300 7.051028e-01 0.152 0 0
RNA Polymerase III Transcription R-HSA-74158 7.051028e-01 0.152 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 7.054227e-01 0.152 0 0
Reverse Transcription of HIV RNA R-HSA-162589 7.067084e-01 0.151 0 0
Minus-strand DNA synthesis R-HSA-164516 7.067084e-01 0.151 0 0
phospho-PLA2 pathway R-HSA-111995 7.067084e-01 0.151 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.067084e-01 0.151 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.067084e-01 0.151 0 0
MET receptor recycling R-HSA-8875656 7.067084e-01 0.151 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.067084e-01 0.151 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 7.067084e-01 0.151 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 7.067084e-01 0.151 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.067084e-01 0.151 0 0
Fructose biosynthesis R-HSA-5652227 7.067084e-01 0.151 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.067084e-01 0.151 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 7.067084e-01 0.151 0 0
SLC-mediated bile acid transport R-HSA-9958517 7.067084e-01 0.151 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.067084e-01 0.151 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.067084e-01 0.151 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 7.089993e-01 0.149 0 0
Packaging Of Telomere Ends R-HSA-171306 7.112058e-01 0.148 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.112058e-01 0.148 0 0
Insulin processing R-HSA-264876 7.112058e-01 0.148 0 0
Platelet activation, signaling and aggregation R-HSA-76002 7.115007e-01 0.148 0 0
Protein localization R-HSA-9609507 7.139330e-01 0.146 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 7.166083e-01 0.145 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 7.166083e-01 0.145 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 7.179796e-01 0.144 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 7.179796e-01 0.144 0 0
Degradation of AXIN R-HSA-4641257 7.217170e-01 0.142 0 0
Viral mRNA Translation R-HSA-192823 7.232444e-01 0.141 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 7.246906e-01 0.140 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 7.257685e-01 0.139 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 7.257685e-01 0.139 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 7.257685e-01 0.139 0 0
Polo-like kinase mediated events R-HSA-156711 7.257685e-01 0.139 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 7.257685e-01 0.139 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 7.257685e-01 0.139 0 0
GAB1 signalosome R-HSA-180292 7.257685e-01 0.139 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 7.297876e-01 0.137 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.297876e-01 0.137 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 7.297876e-01 0.137 0 0
Inflammasomes R-HSA-622312 7.297876e-01 0.137 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 7.376662e-01 0.132 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.376662e-01 0.132 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.376662e-01 0.132 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 7.376662e-01 0.132 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.376662e-01 0.132 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.376662e-01 0.132 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 7.376662e-01 0.132 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 7.376662e-01 0.132 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.376662e-01 0.132 0 0
Interleukin-1 processing R-HSA-448706 7.376662e-01 0.132 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.376662e-01 0.132 0 0
Regulated Necrosis R-HSA-5218859 7.414231e-01 0.130 0 0
Ribosome-associated quality control R-HSA-9948299 7.420389e-01 0.130 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 7.470488e-01 0.127 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 7.470488e-01 0.127 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 7.470488e-01 0.127 0 0
Diseases of hemostasis R-HSA-9671793 7.470488e-01 0.127 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 7.470488e-01 0.127 0 0
Sensory processing of sound R-HSA-9659379 7.520432e-01 0.124 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 7.525645e-01 0.123 0 0
Peroxisomal protein import R-HSA-9033241 7.556671e-01 0.122 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 7.600085e-01 0.119 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 7.600085e-01 0.119 0 0
ER-Phagosome pathway R-HSA-1236974 7.620101e-01 0.118 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 7.641111e-01 0.117 0 0
Interleukin-17 signaling R-HSA-448424 7.646327e-01 0.117 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 7.653579e-01 0.116 0 0
Folding of actin by CCT/TriC R-HSA-390450 7.653579e-01 0.116 0 0
Arachidonate production from DAG R-HSA-426048 7.653579e-01 0.116 0 0
Pexophagy R-HSA-9664873 7.653579e-01 0.116 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.653579e-01 0.116 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 7.668940e-01 0.115 0 0
Nephrin family interactions R-HSA-373753 7.668940e-01 0.115 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 7.673618e-01 0.115 0 0
GABA receptor activation R-HSA-977443 7.677733e-01 0.115 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 7.713849e-01 0.113 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 7.713849e-01 0.113 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 7.713849e-01 0.113 0 0
Interferon alpha/beta signaling R-HSA-909733 7.717290e-01 0.113 0 0
Regulation of mitotic cell cycle R-HSA-453276 7.756538e-01 0.110 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 7.756538e-01 0.110 0 0
Hedgehog 'on' state R-HSA-5632684 7.756538e-01 0.110 0 0
Formation of paraxial mesoderm R-HSA-9793380 7.794277e-01 0.108 0 0
Trafficking of AMPA receptors R-HSA-399719 7.798978e-01 0.108 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 7.798978e-01 0.108 0 0
Molecules associated with elastic fibres R-HSA-2129379 7.798978e-01 0.108 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.798978e-01 0.108 0 0
Downstream signal transduction R-HSA-186763 7.798978e-01 0.108 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.802229e-01 0.108 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 7.806608e-01 0.108 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 7.806608e-01 0.108 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 7.806608e-01 0.108 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 7.812085e-01 0.107 0 0
Interleukin-1 family signaling R-HSA-446652 7.833069e-01 0.106 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.853698e-01 0.105 0 0
Lagging Strand Synthesis R-HSA-69186 7.853698e-01 0.105 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.853698e-01 0.105 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.853698e-01 0.105 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.888519e-01 0.103 0 0
Hedgehog 'off' state R-HSA-5610787 7.896151e-01 0.103 0 0
FGFR2b ligand binding and activation R-HSA-190377 7.901280e-01 0.102 0 0
vRNA Synthesis R-HSA-192814 7.901280e-01 0.102 0 0
vRNP Assembly R-HSA-192905 7.901280e-01 0.102 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.901280e-01 0.102 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.901280e-01 0.102 0 0
Transport of RCbl within the body R-HSA-9758890 7.901280e-01 0.102 0 0
Prostanoid ligand receptors R-HSA-391908 7.901280e-01 0.102 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 7.906351e-01 0.102 0 0
RNA Polymerase II Transcription R-HSA-73857 7.919389e-01 0.101 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 7.926905e-01 0.101 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 7.943926e-01 0.100 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 7.948028e-01 0.100 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 7.971388e-01 0.098 0 0
SARS-CoV Infections R-HSA-9679506 8.015651e-01 0.096 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.025442e-01 0.096 0 0
Serine metabolism R-HSA-977347 8.025442e-01 0.096 0 0
Mitochondrial calcium ion transport R-HSA-8949215 8.025442e-01 0.096 0 0
Assembly Of The HIV Virion R-HSA-175474 8.025442e-01 0.096 0 0
Integration of energy metabolism R-HSA-163685 8.039759e-01 0.095 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 8.045109e-01 0.094 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 8.045109e-01 0.094 0 0
Signaling by NOTCH4 R-HSA-9013694 8.064182e-01 0.093 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 8.069295e-01 0.093 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.069295e-01 0.093 0 0
Depyrimidination R-HSA-73928 8.069295e-01 0.093 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.084629e-01 0.092 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 8.088552e-01 0.092 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.111341e-01 0.091 0 0
Ion transport by P-type ATPases R-HSA-936837 8.117337e-01 0.091 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 8.122845e-01 0.090 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 8.122845e-01 0.090 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 8.122845e-01 0.090 0 0
NF-kB is activated and signals survival R-HSA-209560 8.122845e-01 0.090 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.122845e-01 0.090 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.122845e-01 0.090 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 8.122845e-01 0.090 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.122845e-01 0.090 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.122845e-01 0.090 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 8.122845e-01 0.090 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.122845e-01 0.090 0 0
Uptake of dietary cobalamins into enterocytes R-HSA-9758881 8.122845e-01 0.090 0 0
HCMV Late Events R-HSA-9610379 8.178759e-01 0.087 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 8.184859e-01 0.087 0 0
FGFR2 alternative splicing R-HSA-6803529 8.184859e-01 0.087 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 8.184859e-01 0.087 0 0
Signaling by FGFR4 R-HSA-5654743 8.188364e-01 0.087 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 8.188364e-01 0.087 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 8.209198e-01 0.086 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 8.220858e-01 0.085 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.220858e-01 0.085 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 8.267422e-01 0.083 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 8.267422e-01 0.083 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 8.290701e-01 0.081 0 0
Signaling by NOTCH3 R-HSA-9012852 8.295955e-01 0.081 0 0
Netrin-1 signaling R-HSA-373752 8.301317e-01 0.081 0 0
Amine ligand-binding receptors R-HSA-375280 8.301317e-01 0.081 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 8.321031e-01 0.080 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.321031e-01 0.080 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.321031e-01 0.080 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.321031e-01 0.080 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.321031e-01 0.080 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.321031e-01 0.080 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.321031e-01 0.080 0 0
p75NTR recruits signalling complexes R-HSA-209543 8.321031e-01 0.080 0 0
Signaling by LTK R-HSA-9842663 8.321031e-01 0.080 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.321031e-01 0.080 0 0
Leading Strand Synthesis R-HSA-69109 8.321031e-01 0.080 0 0
Polymerase switching R-HSA-69091 8.321031e-01 0.080 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 8.321031e-01 0.080 0 0
Interleukin-15 signaling R-HSA-8983432 8.321031e-01 0.080 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.321031e-01 0.080 0 0
OAS antiviral response R-HSA-8983711 8.321031e-01 0.080 0 0
Interleukin receptor SHC signaling R-HSA-912526 8.332637e-01 0.079 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 8.332637e-01 0.079 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 8.332637e-01 0.079 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 8.332637e-01 0.079 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 8.334058e-01 0.079 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.345266e-01 0.079 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 8.345266e-01 0.079 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.345266e-01 0.079 0 0
Mitophagy R-HSA-5205647 8.345266e-01 0.079 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 8.355141e-01 0.078 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.379923e-01 0.077 0 0
Signaling by FGFR3 R-HSA-5654741 8.408344e-01 0.075 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 8.408344e-01 0.075 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 8.408344e-01 0.075 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.408344e-01 0.075 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.408344e-01 0.075 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 8.424609e-01 0.074 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 8.424609e-01 0.074 0 0
Regulation of Apoptosis R-HSA-169911 8.462105e-01 0.073 0 0
Complex III assembly R-HSA-9865881 8.469457e-01 0.072 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.469457e-01 0.072 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.469457e-01 0.072 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 8.469457e-01 0.072 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.498303e-01 0.071 0 0
FGFR2c ligand binding and activation R-HSA-190375 8.498303e-01 0.071 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 8.498303e-01 0.071 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.498303e-01 0.071 0 0
FGFR4 ligand binding and activation R-HSA-190322 8.498303e-01 0.071 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 8.498303e-01 0.071 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 8.498303e-01 0.071 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.498303e-01 0.071 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 8.498303e-01 0.071 0 0
FGFR3 mutant receptor activation R-HSA-2033514 8.498303e-01 0.071 0 0
Processing of SMDT1 R-HSA-8949664 8.498303e-01 0.071 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.498303e-01 0.071 0 0
Interleukin-6 signaling R-HSA-1059683 8.498303e-01 0.071 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.498303e-01 0.071 0 0
Signaling by TGFBR3 R-HSA-9839373 8.509646e-01 0.070 0 0
Regulation of insulin secretion R-HSA-422356 8.554477e-01 0.068 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.571706e-01 0.067 0 0
RUNX2 regulates bone development R-HSA-8941326 8.571706e-01 0.067 0 0
Triglyceride catabolism R-HSA-163560 8.571706e-01 0.067 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.595529e-01 0.066 0 0
Tight junction interactions R-HSA-420029 8.595984e-01 0.066 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.595984e-01 0.066 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.595984e-01 0.066 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 8.595984e-01 0.066 0 0
HDMs demethylate histones R-HSA-3214842 8.595984e-01 0.066 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.595984e-01 0.066 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 8.605428e-01 0.065 0 0
Removal of the Flap Intermediate R-HSA-69166 8.656868e-01 0.063 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 8.656868e-01 0.063 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.656868e-01 0.063 0 0
FGFR3c ligand binding and activation R-HSA-190372 8.656868e-01 0.063 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.656868e-01 0.063 0 0
Hydrolysis of LPC R-HSA-1483115 8.656868e-01 0.063 0 0
NRIF signals cell death from the nucleus R-HSA-205043 8.656868e-01 0.063 0 0
cGMP effects R-HSA-418457 8.656868e-01 0.063 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 8.656868e-01 0.063 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 8.656868e-01 0.063 0 0
Prolactin receptor signaling R-HSA-1170546 8.656868e-01 0.063 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.656868e-01 0.063 0 0
Malate-aspartate shuttle R-HSA-9856872 8.656868e-01 0.063 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 8.656868e-01 0.063 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.656868e-01 0.063 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.656868e-01 0.063 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.674404e-01 0.062 0 0
Degradation of DVL R-HSA-4641258 8.674404e-01 0.062 0 0
Cleavage of the damaged purine R-HSA-110331 8.674404e-01 0.062 0 0
TCR signaling R-HSA-202403 8.711836e-01 0.060 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 8.712867e-01 0.060 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.712867e-01 0.060 0 0
Metalloprotease DUBs R-HSA-5689901 8.712867e-01 0.060 0 0
Suppression of phagosomal maturation R-HSA-9637687 8.712867e-01 0.060 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 8.725842e-01 0.059 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 8.750395e-01 0.058 0 0
Elastic fibre formation R-HSA-1566948 8.770530e-01 0.057 0 0
Depurination R-HSA-73927 8.770530e-01 0.057 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.770530e-01 0.057 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 8.781268e-01 0.056 0 0
Disorders of transmembrane transporters R-HSA-5619115 8.790621e-01 0.056 0 0
Signaling by Hedgehog R-HSA-5358351 8.795832e-01 0.056 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 8.798264e-01 0.056 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.798698e-01 0.056 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.798698e-01 0.056 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.798698e-01 0.056 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 8.798698e-01 0.056 0 0
FGFR3 ligand binding and activation R-HSA-190239 8.798698e-01 0.056 0 0
p75NTR signals via NF-kB R-HSA-193639 8.798698e-01 0.056 0 0
Signaling by Activin R-HSA-1502540 8.798698e-01 0.056 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.798698e-01 0.056 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.798698e-01 0.056 0 0
DNA Damage Reversal R-HSA-73942 8.798698e-01 0.056 0 0
PI Metabolism R-HSA-1483255 8.811468e-01 0.055 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.818125e-01 0.055 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 8.819920e-01 0.055 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 8.820730e-01 0.054 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.820730e-01 0.054 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.820730e-01 0.054 0 0
Maturation of hRSV A proteins R-HSA-9828806 8.820730e-01 0.054 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 8.820730e-01 0.054 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 8.848858e-01 0.053 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 8.858402e-01 0.053 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.860415e-01 0.053 0 0
Stabilization of p53 R-HSA-69541 8.860415e-01 0.053 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.860415e-01 0.053 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 8.860415e-01 0.053 0 0
Regulation of RAS by GAPs R-HSA-5658442 8.861749e-01 0.052 0 0
Azathioprine ADME R-HSA-9748787 8.861749e-01 0.052 0 0
PI3K Cascade R-HSA-109704 8.861749e-01 0.052 0 0
Gastrulation R-HSA-9758941 8.873901e-01 0.052 0 0
Mitochondrial protein import R-HSA-1268020 8.890351e-01 0.051 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.890351e-01 0.051 0 0
Co-inhibition by PD-1 R-HSA-389948 8.894358e-01 0.051 0 0
Pyroptosis R-HSA-5620971 8.920174e-01 0.050 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.925558e-01 0.049 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.925558e-01 0.049 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 8.925558e-01 0.049 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.925558e-01 0.049 0 0
Killing mechanisms R-HSA-9664420 8.925558e-01 0.049 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 8.925558e-01 0.049 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.925558e-01 0.049 0 0
Activation of the phototransduction cascade R-HSA-2485179 8.925558e-01 0.049 0 0
Regulation of BACH1 activity R-HSA-9708530 8.925558e-01 0.049 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.925558e-01 0.049 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 8.925558e-01 0.049 0 0
Carnitine synthesis R-HSA-71262 8.925558e-01 0.049 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.925558e-01 0.049 0 0
Attachment and Entry R-HSA-9678110 8.925558e-01 0.049 0 0
Signaling by FGFR in disease R-HSA-1226099 8.931827e-01 0.049 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 8.937550e-01 0.049 0 0
Hedgehog ligand biogenesis R-HSA-5358346 8.937550e-01 0.049 0 0
Glycogen metabolism R-HSA-8982491 8.944380e-01 0.048 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.944380e-01 0.048 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 8.951380e-01 0.048 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.975187e-01 0.047 0 0
Iron uptake and transport R-HSA-917937 8.993723e-01 0.046 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.002781e-01 0.046 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 9.011775e-01 0.045 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.015020e-01 0.045 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.022744e-01 0.045 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.022744e-01 0.045 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.022744e-01 0.045 0 0
IGF1R signaling cascade R-HSA-2428924 9.023462e-01 0.045 0 0
Heme assimilation R-HSA-9927020 9.039029e-01 0.044 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 9.039029e-01 0.044 0 0
Passive transport by Aquaporins R-HSA-432047 9.039029e-01 0.044 0 0
Formation of xylulose-5-phosphate R-HSA-5661270 9.039029e-01 0.044 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.039029e-01 0.044 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 9.039029e-01 0.044 0 0
UCH proteinases R-HSA-5689603 9.052517e-01 0.043 0 0
Ub-specific processing proteases R-HSA-5689880 9.052654e-01 0.043 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.075951e-01 0.042 0 0
Cellular response to hypoxia R-HSA-1234174 9.084647e-01 0.042 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.084647e-01 0.042 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.095814e-01 0.041 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.095814e-01 0.041 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.095814e-01 0.041 0 0
Translation of Structural Proteins R-HSA-9683701 9.095814e-01 0.041 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 9.096080e-01 0.041 0 0
DAP12 signaling R-HSA-2424491 9.096080e-01 0.041 0 0
PPARA activates gene expression R-HSA-1989781 9.130530e-01 0.040 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.138959e-01 0.039 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.140522e-01 0.039 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.140522e-01 0.039 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.140522e-01 0.039 0 0
Glycogen storage diseases R-HSA-3229121 9.140522e-01 0.039 0 0
Synthesis of 15-eicosatetraenoic acid derivatives R-HSA-2142770 9.140522e-01 0.039 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 9.140522e-01 0.039 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 9.140522e-01 0.039 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.140522e-01 0.039 0 0
Choline catabolism R-HSA-6798163 9.140522e-01 0.039 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.140522e-01 0.039 0 0
RNA Polymerase I Transcription R-HSA-73864 9.161256e-01 0.038 0 0
Interleukin-10 signaling R-HSA-6783783 9.161256e-01 0.038 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 9.163890e-01 0.038 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.163890e-01 0.038 0 0
Budding and maturation of HIV virion R-HSA-162588 9.173607e-01 0.037 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.173607e-01 0.037 0 0
Platelet degranulation R-HSA-114608 9.175088e-01 0.037 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.204462e-01 0.036 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 9.231301e-01 0.035 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.231301e-01 0.035 0 0
Activated point mutants of FGFR2 R-HSA-2033519 9.231301e-01 0.035 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.231301e-01 0.035 0 0
PKA activation in glucagon signalling R-HSA-164378 9.231301e-01 0.035 0 0
PKA activation R-HSA-163615 9.231301e-01 0.035 0 0
Tie2 Signaling R-HSA-210993 9.231301e-01 0.035 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.231301e-01 0.035 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.244847e-01 0.034 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.244847e-01 0.034 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 9.248490e-01 0.034 0 0
Signaling by FGFR1 R-HSA-5654736 9.253581e-01 0.034 0 0
Signaling by FGFR2 R-HSA-5654738 9.258953e-01 0.033 0 0
Signaling by Nuclear Receptors R-HSA-9006931 9.269236e-01 0.033 0 0
Interleukin-1 signaling R-HSA-9020702 9.303083e-01 0.031 0 0
IRS-mediated signalling R-HSA-112399 9.305578e-01 0.031 0 0
Synthesis of PA R-HSA-1483166 9.305578e-01 0.031 0 0
Toll-like Receptor Cascades R-HSA-168898 9.307547e-01 0.031 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.310264e-01 0.031 0 0
Cardiogenesis R-HSA-9733709 9.310264e-01 0.031 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.312497e-01 0.031 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.312497e-01 0.031 0 0
Specification of the neural plate border R-HSA-9834899 9.312497e-01 0.031 0 0
Translesion Synthesis by POLH R-HSA-110320 9.312497e-01 0.031 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 9.312497e-01 0.031 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.312497e-01 0.031 0 0
Potential therapeutics for SARS R-HSA-9679191 9.330093e-01 0.030 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.340988e-01 0.030 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 9.342722e-01 0.030 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 9.361154e-01 0.029 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.370291e-01 0.028 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.370291e-01 0.028 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.370291e-01 0.028 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.385120e-01 0.028 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.385120e-01 0.028 0 0
Glycogen synthesis R-HSA-3322077 9.385120e-01 0.028 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.385120e-01 0.028 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.385120e-01 0.028 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.385120e-01 0.028 0 0
Pregnenolone biosynthesis R-HSA-196108 9.385120e-01 0.028 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.385120e-01 0.028 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 9.385751e-01 0.028 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.391869e-01 0.027 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.391869e-01 0.027 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.391869e-01 0.027 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.392513e-01 0.027 0 0
Triglyceride metabolism R-HSA-8979227 9.399857e-01 0.027 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.399857e-01 0.027 0 0
Translation R-HSA-72766 9.407529e-01 0.027 0 0
Hemostasis R-HSA-109582 9.413532e-01 0.026 0 0
Selenoamino acid metabolism R-HSA-2408522 9.422951e-01 0.026 0 0
eNOS activation R-HSA-203615 9.425339e-01 0.026 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.425339e-01 0.026 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.425339e-01 0.026 0 0
Adaptive Immune System R-HSA-1280218 9.430887e-01 0.025 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.439093e-01 0.025 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.439093e-01 0.025 0 0
Synthesis of PC R-HSA-1483191 9.439093e-01 0.025 0 0
RAB geranylgeranylation R-HSA-8873719 9.442487e-01 0.025 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.442487e-01 0.025 0 0
RSV-host interactions R-HSA-9833110 9.446053e-01 0.025 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.450076e-01 0.025 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.450076e-01 0.025 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 9.450076e-01 0.025 0 0
Phenylalanine metabolism R-HSA-8964208 9.450076e-01 0.025 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 9.450076e-01 0.025 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.450076e-01 0.025 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.450076e-01 0.025 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.450076e-01 0.025 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.475787e-01 0.023 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.475787e-01 0.023 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.475787e-01 0.023 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.475787e-01 0.023 0 0
Gluconeogenesis R-HSA-70263 9.482891e-01 0.023 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.494502e-01 0.023 0 0
Signaling by ERBB4 R-HSA-1236394 9.500046e-01 0.022 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.508173e-01 0.022 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.508173e-01 0.022 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.508173e-01 0.022 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.508173e-01 0.022 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.508173e-01 0.022 0 0
Attachment and Entry R-HSA-9694614 9.508173e-01 0.022 0 0
Signaling by PDGF R-HSA-186797 9.519547e-01 0.021 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.521995e-01 0.021 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.523485e-01 0.021 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.560136e-01 0.020 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.560136e-01 0.020 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 9.560136e-01 0.020 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.560136e-01 0.020 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.560136e-01 0.020 0 0
Fructose metabolism R-HSA-5652084 9.560136e-01 0.020 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.560136e-01 0.020 0 0
Ethanol oxidation R-HSA-71384 9.560136e-01 0.020 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.560136e-01 0.020 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.560136e-01 0.020 0 0
Stimuli-sensing channels R-HSA-2672351 9.562460e-01 0.019 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.564293e-01 0.019 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.564293e-01 0.019 0 0
Metabolism of folate and pterines R-HSA-196757 9.564293e-01 0.019 0 0
Signaling by NOTCH1 R-HSA-1980143 9.565131e-01 0.019 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 9.565131e-01 0.019 0 0
Insulin receptor signalling cascade R-HSA-74751 9.586698e-01 0.018 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.586698e-01 0.018 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.595895e-01 0.018 0 0
The phototransduction cascade R-HSA-2514856 9.595895e-01 0.018 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.602993e-01 0.018 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.606611e-01 0.017 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.606611e-01 0.017 0 0
Syndecan interactions R-HSA-3000170 9.606611e-01 0.017 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.606611e-01 0.017 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.606611e-01 0.017 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.606611e-01 0.017 0 0
Carnitine shuttle R-HSA-200425 9.606611e-01 0.017 0 0
PCP/CE pathway R-HSA-4086400 9.622385e-01 0.017 0 0
ABC transporter disorders R-HSA-5619084 9.622385e-01 0.017 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.636763e-01 0.016 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.638383e-01 0.016 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.648178e-01 0.016 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.648178e-01 0.016 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 9.648178e-01 0.016 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.648178e-01 0.016 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.648178e-01 0.016 0 0
Interleukin-6 family signaling R-HSA-6783589 9.648178e-01 0.016 0 0
Cardiac conduction R-HSA-5576891 9.648703e-01 0.016 0 0
Viral Infection Pathways R-HSA-9824446 9.653891e-01 0.015 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 9.657874e-01 0.015 0 0
Nucleotide biosynthesis R-HSA-8956320 9.657874e-01 0.015 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.660402e-01 0.015 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.661910e-01 0.015 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 9.670729e-01 0.015 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.670729e-01 0.015 0 0
Interleukin-2 family signaling R-HSA-451927 9.670729e-01 0.015 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.671294e-01 0.015 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 9.672636e-01 0.014 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.676918e-01 0.014 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.685356e-01 0.014 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.685356e-01 0.014 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.685356e-01 0.014 0 0
Hyaluronan degradation R-HSA-2160916 9.685356e-01 0.014 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 9.685356e-01 0.014 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.685356e-01 0.014 0 0
Formation of the nephric duct R-HSA-9830364 9.685356e-01 0.014 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.685356e-01 0.014 0 0
Laminin interactions R-HSA-3000157 9.685356e-01 0.014 0 0
Immune System R-HSA-168256 9.697733e-01 0.013 0 0
HDACs deacetylate histones R-HSA-3214815 9.710806e-01 0.013 0 0
MET activates PTK2 signaling R-HSA-8874081 9.718606e-01 0.012 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.718606e-01 0.012 0 0
Urea cycle R-HSA-70635 9.718606e-01 0.012 0 0
Sphingolipid catabolism R-HSA-9845614 9.718606e-01 0.012 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.718606e-01 0.012 0 0
Intra-Golgi traffic R-HSA-6811438 9.727263e-01 0.012 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.727263e-01 0.012 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.727263e-01 0.012 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.739516e-01 0.011 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.748345e-01 0.011 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.748345e-01 0.011 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.748345e-01 0.011 0 0
Signaling by BMP R-HSA-201451 9.748345e-01 0.011 0 0
Triglyceride biosynthesis R-HSA-75109 9.748345e-01 0.011 0 0
Synthesis of PE R-HSA-1483213 9.748345e-01 0.011 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 9.748345e-01 0.011 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.748345e-01 0.011 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.751894e-01 0.011 0 0
Defective pyroptosis R-HSA-9710421 9.774366e-01 0.010 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.774942e-01 0.010 0 0
HIV elongation arrest and recovery R-HSA-167287 9.774942e-01 0.010 0 0
Pausing and recovery of HIV elongation R-HSA-167290 9.774942e-01 0.010 0 0
Insulin receptor recycling R-HSA-77387 9.774942e-01 0.010 0 0
Pyrimidine salvage R-HSA-73614 9.774942e-01 0.010 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.775879e-01 0.010 0 0
G alpha (i) signalling events R-HSA-418594 9.779302e-01 0.010 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.790178e-01 0.009 0 0
Potassium Channels R-HSA-1296071 9.790178e-01 0.009 0 0
DAP12 interactions R-HSA-2172127 9.794862e-01 0.009 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.798730e-01 0.009 0 0
mRNA Capping R-HSA-72086 9.798730e-01 0.009 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.798730e-01 0.009 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.798730e-01 0.009 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.798730e-01 0.009 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.798730e-01 0.009 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.803784e-01 0.009 0 0
Signaling by NOTCH R-HSA-157118 9.807236e-01 0.008 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 9.811238e-01 0.008 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 9.811238e-01 0.008 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 9.811238e-01 0.008 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 9.811238e-01 0.008 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 9.811238e-01 0.008 0 0
Signaling by FGFR R-HSA-190236 9.817728e-01 0.008 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.820005e-01 0.008 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.820005e-01 0.008 0 0
Neurotransmitter clearance R-HSA-112311 9.820005e-01 0.008 0 0
G alpha (q) signalling events R-HSA-416476 9.824140e-01 0.008 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.826853e-01 0.008 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.839032e-01 0.007 0 0
Cargo concentration in the ER R-HSA-5694530 9.839032e-01 0.007 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.839032e-01 0.007 0 0
Ion channel transport R-HSA-983712 9.845549e-01 0.007 0 0
Translation of Structural Proteins R-HSA-9694635 9.850556e-01 0.007 0 0
Cellular response to chemical stress R-HSA-9711123 9.854099e-01 0.006 0 0
Neurotransmitter release cycle R-HSA-112310 9.854681e-01 0.006 0 0
Downstream TCR signaling R-HSA-202424 9.854681e-01 0.006 0 0
Transmission across Chemical Synapses R-HSA-112315 9.856004e-01 0.006 0 0
Metal ion SLC transporters R-HSA-425410 9.860217e-01 0.006 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.862147e-01 0.006 0 0
Integrin cell surface interactions R-HSA-216083 9.862147e-01 0.006 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.871267e-01 0.006 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.873079e-01 0.006 0 0
Interferon gamma signaling R-HSA-877300 9.878623e-01 0.005 0 0
Generic Transcription Pathway R-HSA-212436 9.880467e-01 0.005 0 0
Post-translational protein modification R-HSA-597592 9.882361e-01 0.005 0 0
Signaling by Insulin receptor R-HSA-74752 9.884383e-01 0.005 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.884383e-01 0.005 0 0
Heme degradation R-HSA-189483 9.884877e-01 0.005 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 9.889773e-01 0.005 0 0
Activation of HOX genes during differentiation R-HSA-5619507 9.889773e-01 0.005 0 0
Amyloid fiber formation R-HSA-977225 9.892004e-01 0.005 0 0
Meiotic recombination R-HSA-912446 9.895435e-01 0.005 0 0
Hyaluronan metabolism R-HSA-2142845 9.897050e-01 0.004 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.897050e-01 0.004 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.897050e-01 0.004 0 0
NOD1/2 Signaling Pathway R-HSA-168638 9.897050e-01 0.004 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.897050e-01 0.004 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.900884e-01 0.004 0 0
Mitochondrial protein degradation R-HSA-9837999 9.900884e-01 0.004 0 0
Peptide hormone metabolism R-HSA-2980736 9.904111e-01 0.004 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.905122e-01 0.004 0 0
Transcription of the HIV genome R-HSA-167172 9.906210e-01 0.004 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.907936e-01 0.004 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.907936e-01 0.004 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.907936e-01 0.004 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.908363e-01 0.004 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.913857e-01 0.004 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.915626e-01 0.004 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 9.916727e-01 0.004 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.917671e-01 0.004 0 0
Glycosphingolipid transport R-HSA-9845576 9.917671e-01 0.004 0 0
GPVI-mediated activation cascade R-HSA-114604 9.917671e-01 0.004 0 0
HS-GAG biosynthesis R-HSA-2022928 9.917671e-01 0.004 0 0
NCAM1 interactions R-HSA-419037 9.926377e-01 0.003 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.926377e-01 0.003 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.926377e-01 0.003 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 9.928188e-01 0.003 0 0
Neuronal System R-HSA-112316 9.929208e-01 0.003 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.934164e-01 0.003 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.934164e-01 0.003 0 0
Pentose phosphate pathway R-HSA-71336 9.941127e-01 0.003 0 0
Signaling by ALK R-HSA-201556 9.941127e-01 0.003 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.941127e-01 0.003 0 0
Dectin-2 family R-HSA-5621480 9.941830e-01 0.003 0 0
ABC-family proteins mediated transport R-HSA-382556 9.942710e-01 0.002 0 0
G alpha (s) signalling events R-HSA-418555 9.945527e-01 0.002 1 1
C-type lectin receptors (CLRs) R-HSA-5621481 9.945527e-01 0.002 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.947354e-01 0.002 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 9.947354e-01 0.002 0 0
Tryptophan catabolism R-HSA-71240 9.947354e-01 0.002 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.947354e-01 0.002 0 0
Regulation of beta-cell development R-HSA-186712 9.952234e-01 0.002 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.952234e-01 0.002 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.952923e-01 0.002 0 0
Maturation of spike protein R-HSA-9694548 9.952923e-01 0.002 0 0
tRNA Aminoacylation R-HSA-379724 9.956728e-01 0.002 0 0
Metabolism of polyamines R-HSA-351202 9.956728e-01 0.002 0 0
HIV Transcription Initiation R-HSA-167161 9.957903e-01 0.002 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.957903e-01 0.002 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.957903e-01 0.002 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.957903e-01 0.002 0 0
Cholesterol biosynthesis R-HSA-191273 9.961821e-01 0.002 0 0
Phospholipid metabolism R-HSA-1483257 9.961937e-01 0.002 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.966339e-01 0.001 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.966579e-01 0.001 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.969900e-01 0.001 0 0
Surfactant metabolism R-HSA-5683826 9.969900e-01 0.001 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.973085e-01 0.001 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.973085e-01 0.001 0 0
The canonical retinoid cycle in rods (twilight vision) R-HSA-2453902 9.973085e-01 0.001 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.973781e-01 0.001 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.974555e-01 0.001 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.975933e-01 0.001 0 0
Parasitic Infection Pathways R-HSA-9824443 9.976988e-01 0.001 0 0
Leishmania infection R-HSA-9658195 9.976988e-01 0.001 0 0
Neddylation R-HSA-8951664 9.977235e-01 0.001 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.978480e-01 0.001 0 0
Peptide ligand-binding receptors R-HSA-375276 9.979435e-01 0.001 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.980757e-01 0.001 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.981540e-01 0.001 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.981742e-01 0.001 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 9.982348e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.984034e-01 0.001 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.984470e-01 0.001 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.984615e-01 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.984615e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.985560e-01 0.001 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.985862e-01 0.001 0 0
Parasite infection R-HSA-9664407 9.985862e-01 0.001 0 0
Leishmania phagocytosis R-HSA-9664417 9.985862e-01 0.001 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.986788e-01 0.001 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.987699e-01 0.001 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.988195e-01 0.001 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.990354e-01 0.000 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.992138e-01 0.000 0 0
Developmental Cell Lineages R-HSA-9734767 9.992182e-01 0.000 0 0
Collagen formation R-HSA-1474290 9.992825e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.992882e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.993674e-01 0.000 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.993715e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.993821e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.994380e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.994599e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.995508e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.995508e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.995535e-01 0.000 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 9.995983e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.996409e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.997184e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.997184e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.997232e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.997492e-01 0.000 0 0
Kidney development R-HSA-9830369 9.997705e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.997705e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.997705e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.997705e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.997948e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.997948e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.998383e-01 0.000 1 0
Metabolism of nucleotides R-HSA-15869 9.998505e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.998534e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.998534e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.998534e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.998534e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.998590e-01 0.000 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.998615e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.998689e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.998860e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.998947e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.998952e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.998952e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999063e-01 0.000 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.999170e-01 0.000 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.999252e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.999353e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999414e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999497e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999522e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999522e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999665e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999705e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999756e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999782e-01 0.000 0 0
Developmental Biology R-HSA-1266738 9.999798e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999801e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999855e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999888e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999891e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999891e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999906e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999912e-01 0.000 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.999927e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999929e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999937e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999944e-01 0.000 1 0
Innate Immune System R-HSA-168249 9.999946e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999951e-01 0.000 0 0
Disease R-HSA-1643685 9.999966e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999976e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999977e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999982e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999983e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999987e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999992e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999993e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999994e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999995e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999996e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999998e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999999e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999999e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways