NUAK1

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A5A3E0 S939 Sugiyama POTEF A26C1B VALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPE
A5A3E0 Y940 Sugiyama POTEF A26C1B ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
O14974 S445 GPS6|SIGNOR|EPSD|PSP PPP1R12A MBS MYPT1 EEERKDEsPATWRLGLRKtGsyGALAEItASKEGQKEKDTA
O14974 S472 GPS6|SIGNOR|EPSD|PSP PPP1R12A MBS MYPT1 ItASKEGQKEKDTAGVTRsAssPRLsssLDNKEKEKDSKGT
O14974 S910 GPS6|SIGNOR|EPSD|PSP|Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O43823 S323 Sugiyama AKAP8 AKAP95 RKRKQFQLyEEPDtKLARVDsEGDFsENDDAAGDFRsGDEE
O43852 S44 Sugiyama CALU KKDRVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQL
O60285 S266 Sugiyama NUAK1 ARK5 KIAA0537 OMPHK1 LVYGTMPFDGFDHKNLIRQIsSGEYREPTQPSDARGLIRWM
O60285 S313 Sugiyama NUAK1 ARK5 KIAA0537 OMPHK1 RRATIEDIANHWWVNWGYKSsVCDCDALHDsEsPLLARIID
O60285 S323 Sugiyama NUAK1 ARK5 KIAA0537 OMPHK1 HWWVNWGYKSsVCDCDALHDsEsPLLARIIDWHHRSTGLQA
O60285 S325 Sugiyama NUAK1 ARK5 KIAA0537 OMPHK1 WVNWGYKSsVCDCDALHDsEsPLLARIIDWHHRSTGLQADT
O60285 S358 Sugiyama NUAK1 ARK5 KIAA0537 OMPHK1 STGLQADTEAKMKGLAKPtTsEVMLERQRSLKKSKKENDFA
O60285 S380 Sugiyama NUAK1 ARK5 KIAA0537 OMPHK1 VMLERQRSLKKSKKENDFAQsGQDAVPEsPsKLSSKRPKGI
O60285 S388 Sugiyama NUAK1 ARK5 KIAA0537 OMPHK1 LKKSKKENDFAQsGQDAVPEsPsKLSSKRPKGILKKRSNSE
O60285 S390 Sugiyama NUAK1 ARK5 KIAA0537 OMPHK1 KSKKENDFAQsGQDAVPEsPsKLSSKRPKGILKKRSNSEHR
O60285 S444 Sugiyama NUAK1 ARK5 KIAA0537 OMPHK1 ALPSTFKMEQDLCRTGVLLPssPEAEVPGKLsPKQSATMPK
O60285 S445 Sugiyama NUAK1 ARK5 KIAA0537 OMPHK1 LPSTFKMEQDLCRTGVLLPssPEAEVPGKLsPKQSATMPKK
O60285 S455 Sugiyama NUAK1 ARK5 KIAA0537 OMPHK1 LCRTGVLLPssPEAEVPGKLsPKQSATMPKKGILKKTQQRE
O60285 T356 Sugiyama NUAK1 ARK5 KIAA0537 OMPHK1 HRSTGLQADTEAKMKGLAKPtTsEVMLERQRSLKKSKKEND
O60285 T60 Sugiyama NUAK1 ARK5 KIAA0537 OMPHK1 HGVKRHHHKHNLKHRYELQEtLGKGTYGKVKRATERFSGRV
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O95218 S181 Sugiyama ZRANB2 ZIS ZNF265 DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
O95297 S260 Sugiyama MPZL1 PZR UNQ849/PRO1787 IyAQLDHsGGHHSDKINKSEsVVyADIRKN___________
O95678 S162 Sugiyama KRT75 K6HF KB18 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
O95835 S464 GPS6|SIGNOR|EPSD|PSP LATS1 WARTS SPSSGHEIPTWQPNIPVRsNsFNNPLGNRASHSANSQPSAT
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00338 S319 Sugiyama LDHA PIG19 GISDLVKVTLtsEEEARLKKsADtLWGIQKELQF_______
P02538 S176 Sugiyama KRT6A K6A KRT6D IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P02545 S295 Sugiyama LMNA LMN1 RQsAERNsNLVGAAHEELQQsRIRIDsLsAQLsQLQKQLAA
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04259 S176 Sugiyama KRT6B K6B KRTL1 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04637 S15 GPS6|SIGNOR|EPSD|PSP TP53 P53 ______MEEPQsDPsVEPPLsQEtFsDLWKLLPENNVLsPL
P04637 S392 GPS6|SIGNOR|EPSD|PSP TP53 P53 KKGQstsRHKKLMFKtEGPDsD___________________
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05198 S219 Sugiyama EIF2S1 EIF2A CYGYEGIDAVKEALRAGLNCsTENMPIKINLIAPPRYVMTT
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05455 S94 Sugiyama SSB KSKAELMEIsEDKTKIRRsPsKPLPEVTDEyKNDVKNRsVY
P05787 S104 Sugiyama KRT8 CYK8 IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P06733 S27 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07237 S439 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB NIVIAKMDstANEVEAVKVHsFPtLKFFPAsADRtVIDyNG
P07237 T442 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB IAKMDstANEVEAVKVHsFPtLKFFPAsADRtVIDyNGERt
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900 S470 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA HEDsQNRKKLsELLRyytsAsGDEMVsLKDYCTRMKENQKH
P07900 S52 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900 S53 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P07900 T317 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA WtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 S48 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08238 T309 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB WtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08729 S104 Sugiyama KRT7 SCL LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P0DPH7 T41 Sugiyama TUBA3C TUBA2 WELYCLEHGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKH
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P12004 S172 Sugiyama PCNA sHIGDAVVIsCAKDGVKFSAsGELGNGNIKLSQTSNVDKEE
P12035 S211 Sugiyama KRT3 IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P13647 S181 Sugiyama KRT5 IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13798 S187 Sugiyama APEH D3F15S2 D3S48E DNF15S2 EKKRPKAEsFFQTKALDVsAsDDEIARLKKPDQAIKGDQFV
P14625 S109 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P14625 T171 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 GVGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSEL
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P18754 S85 Sugiyama RCC1 CHC1 IPEDVVQAEAGGMHTVCLSKsGQVysFGCNDEGALGRDtsV
P22090 S204 Sugiyama RPS4Y1 RPS4Y PRO2646 IGGANLGRVGVITNRERHPGsFDVVHVKDANGNSFATRLSN
P22626 S189 Sugiyama HNRNPA2B1 HNRPA2B1 IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P23588 S122 Sugiyama EIF4B NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P30622 S973 Sugiyama CLIP1 CYLN1 RSN LKERDVEELQLKLTKANENAsFLQKSIEDMTVKAEQSQQEA
P31943 S23 Sugiyama HNRNPH1 HNRPH HNRPH1 LGTEGGEGFVVKVRGLPWsCsADEVQRFFSDCKIQNGAQGI
P32119 T142 Sugiyama PRDX2 NKEFB TDPX1 EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P35579 S1713 Sugiyama MYH9 ERAKRQAQQERDELADEIANssGKGALALEEKRRLEARIAQ
P35579 S1714 Sugiyama MYH9 RAKRQAQQERDELADEIANssGKGALALEEKRRLEARIAQL
P35579 S1892 Sugiyama MYH9 LKQLKRQLEEAEEEAQRANAsRRKLQRELEDAtEtADAMNR
P35908 S191 Sugiyama KRT2 KRT2A KRT2E IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38936 S146 PSP CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1 QAEGsPGGPGDSQGRKRRQtsMTDFYHsKRRLIFSKRKP__
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P42677 S78 Sugiyama RPS27 MPS1 GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P48637 S276 Sugiyama GSS VDGQEIAVVYFRDGYMPRQYsLQNWEARLLLERSHAAKCPD
P48668 S176 Sugiyama KRT6C KRT6E IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P52597 S63 Sugiyama HNRNPF HNRPF VHFIYTREGRQsGEAFVELGsEDDVKMALKKDRESMGHRyI
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P54252 S260 Sugiyama ATXN3 ATX3 MJD MJD1 SCA3 IDMEDEEADLRRAIQLsMQGssRNIsQDMtQtsGTNLTSEE
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P55212 S257 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP CASP6 MCH2 GKYGSSLEFTELLTLVNRKVsQRRVDFCKDPSAIGKKQVPC
P60709 S239 Sugiyama ACTB VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P60709 Y240 Sugiyama ACTB ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P61247 S236 Sugiyama RPS3A FTE1 MFTL KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61247 S237 Sugiyama RPS3A FTE1 MFTL MLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGyE
P61247 S238 Sugiyama RPS3A FTE1 MFTL LKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGyEP
P61313 S97 Sugiyama RPL15 EC45 TCBAP0781 KGAtyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLN
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62701 S204 Sugiyama RPS4X CCG2 RPS4 SCAR tGGANLGRIGVITNRERHPGsFDVVHVKDANGNSFATRLsN
P62736 S241 Sugiyama ACTA2 ACTSA ACTVS GIG46 VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P62736 Y242 Sugiyama ACTA2 ACTSA ACTVS GIG46 ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P63261 S239 Sugiyama ACTG1 ACTG VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63261 Y240 Sugiyama ACTG1 ACTG ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63267 S240 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63267 Y241 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68032 S241 Sugiyama ACTC1 ACTC VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68032 Y242 Sugiyama ACTC1 ACTC ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68133 S241 Sugiyama ACTA1 ACTA VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68133 Y242 Sugiyama ACTA1 ACTA ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68363 T41 Sugiyama TUBA1B WELYCLEHGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKH
P83731 S38 Sugiyama RPL24 GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P83731 S7 Sugiyama RPL24 ______________MKVELCsFsGyKIYPGHGRRYARTDGK
P83731 S86 Sugiyama RPL24 EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098 S37 Sugiyama RPL19 CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
P84098 T29 Sugiyama RPL19 RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
Q01082 S1388 Sugiyama SPTBN1 SPTB2 TTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSDDy
Q01105 S161 Sugiyama SET FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q01105 S166 Sugiyama SET yFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQT
Q01546 S196 Sugiyama KRT76 KRT2B KRT2P IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q06210 S261 Sugiyama GFPT1 GFAT GFPT GsQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDA
Q06830 T143 Sugiyama PRDX1 PAGA PAGB TDPX2 EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q09028 S146 Sugiyama RBBP4 RBAP48 EVNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGE
Q09028 S147 Sugiyama RBBP4 RBAP48 VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC
Q13263 S471 Sugiyama TRIM28 KAP1 RNF96 TIF1B FGsGDDPyssAEPHVsGVKRsRsGEGEVsGLMRKVPRVsLE
Q13263 S473 Sugiyama TRIM28 KAP1 RNF96 TIF1B sGDDPyssAEPHVsGVKRsRsGEGEVsGLMRKVPRVsLERL
Q14152 S492 Sugiyama EIF3A EIF3S10 KIAA0139 VDAARHCDLQVRIDHTSRTLsFGsDLNyAtREDAPIGPHLQ
Q14568 S52 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14568 S53 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14CN4 S138 Sugiyama KRT72 K6IRS2 KB35 KRT6 KRT6IRS2 IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q16513 T958 Sugiyama PKN2 PRK2 PRKCL2 RGREDVSNFDDEFtsEAPILtPPREPRILsEEEQEMFRDFD
Q16576 S145 Sugiyama RBBP7 RBAP46 EVNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGE
Q16576 S146 Sugiyama RBBP7 RBAP46 VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC
Q16658 S237 Sugiyama FSCN1 FAN1 HSN SNL RsGKVAFRDCEGRyLAPsGPsGtLKAGKATKVGKDELFALE
Q3SY84 S143 Sugiyama KRT71 K6IRS1 KB34 KRT6IRS1 IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q562R1 S240 Sugiyama ACTBL2 VALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPE
Q562R1 Y241 Sugiyama ACTBL2 ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q5H9R7 S579 Sugiyama PPP6R3 C11orf23 KIAA1558 PP6R3 SAPL SAPS3 IDQFGFNDEKFADQDDIGNVsFDRVSDINFTLNTNESGNIA
Q5T035 S66 Sugiyama FAM120A2P C9orf129 LSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyERSLPI
Q5XKE5 S155 Sugiyama KRT79 K6L KB38 KRT6L IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q6FI81 S305 Sugiyama CIAPIN1 CUA001 PRO0915 CAsCPyLGMPAFKPGEKVLLsDsNLHDA_____________
Q6GYQ0 S797 Sugiyama RALGAPA1 GARNL1 KIAA0884 TULIP1 EtGNEVFGALNEEQPLPRssstsDILEPFTVERAKVNKEDM
Q6PEY2 T41 Sugiyama TUBA3E WELYCLEHGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKH
Q6S8J3 S939 Sugiyama POTEE A26C1A POTE2 VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
Q6S8J3 Y940 Sugiyama POTEE A26C1A POTE2 ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q71U36 T41 Sugiyama TUBA1A TUBA3 WELYCLEHGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKH
Q71UM5 S78 Sugiyama RPS27L GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q7RTS7 S153 Sugiyama KRT74 K6IRS4 KB37 KRT5C KRT6IRS4 IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z2W4 S492 Sugiyama ZC3HAV1 ZC3HDC2 PRO1677 VQATGRIADDADPRVALVNDsLsDVtsTtssRVDDHDSEEI
Q7Z794 S177 Sugiyama KRT77 KRT1B IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86Y46 S145 Sugiyama KRT73 K6IRS3 KB36 KRT6IRS3 IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8N806 S265 Sugiyama UBR7 C14orf130 KDDVREVKVEQNsEPCAGsssEsDLQtVFKNESLNAESKSG
Q8NBP7 S488 Sugiyama PCSK9 NARC1 PSEC0052 TRMATAVARCAPDEELLsCssFSRSGKRRGERMEAQGGKLV
Q8TDD1 S581 Sugiyama DDX54 RLVDSIKNYRSRATIFEINAsSRDLCsQVMRAKRQKDRKAI
Q96HC4 S362 Sugiyama PDLIM5 ENH L9 SLTAAAAFKPVGStGVIKsPsWQRPNQGVPstGRIsNsAtY
Q96IZ0 S259 Sugiyama PAWR PAR4 SRYsRTDRSGFPRYNRDANVsGtLVSSstLEKKIEDLEKEV
Q96N67 S1432 Sugiyama DOCK7 KIAA1771 RRSRGQLGTYTIAsPPERsPsGsAFGsQENLRWRKDMTHWR
Q9BQE3 T41 Sugiyama TUBA1C TUBA6 WELYCLEHGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKH
Q9BYX7 S239 Sugiyama POTEKP ACTBL3 FKSG30 VALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPE
Q9BYX7 Y240 Sugiyama POTEKP ACTBL3 FKSG30 ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9H788 S315 Sugiyama SH2D4A PPP1R38 SH2A LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9H7E9 T40 Sugiyama C8orf33 PCAsRGARLPGPVsSARNPstVCLCPEQPTCSNADSRAHPL
Q9HA92 S173 Sugiyama RSAD1 LSIGLQSLDDTELRLLGRtHsACDALRTLAEARRLFPGRVS
Q9HA92 T171 Sugiyama RSAD1 NRLSIGLQSLDDTELRLLGRtHsACDALRTLAEARRLFPGR
Q9NSB2 S178 Sugiyama KRT84 KRTHB4 AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9NYB9 S22 Sugiyama ABI2 ARGBPIA AELQMLLEEEIPGGRRALFDsytNLERVADyCENNyIQSAD
Q9NZB2 S417 Sugiyama FAM120A C9orf10 KIAA0183 OSSA LSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyERssPI
Q9UII2 S63 Sugiyama ATP5IF1 ATPI ATPIF1 AGGAFGKREQAEEERyFRAQsREQLAALKKHHEEEIVHHKK
Q9UKV8 S387 Sugiyama AGO2 EIF2C2 ATARSAPDRQEEISKLMRsAsFNTDPyVREFGIMVKDEMTD
Q9Y2B0 S55 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDELEWEIAQVDPKKTIQMGsFRINPDGsQsVVEVPyARsE
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Signal Transduction R-HSA-162582 4.633078e-09 8.334 0 0
Cell Cycle R-HSA-1640170 1.344187e-07 6.872 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.035919e-07 6.691 0 0
Axon guidance R-HSA-422475 9.905601e-07 6.004 0 0
Nervous system development R-HSA-9675108 4.403002e-06 5.356 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.065792e-05 4.685 0 0
Cell Cycle, Mitotic R-HSA-69278 3.162902e-05 4.500 0 0
Death Receptor Signaling R-HSA-73887 4.551097e-05 4.342 0 0
Mitotic Prometaphase R-HSA-68877 5.572940e-05 4.254 0 0
Apoptotic execution phase R-HSA-75153 5.642691e-05 4.249 0 0
Intracellular signaling by second messengers R-HSA-9006925 9.004174e-05 4.046 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.013785e-04 3.994 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.322373e-04 3.879 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.817437e-04 3.741 0 0
NRAGE signals death through JNK R-HSA-193648 1.938594e-04 3.713 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.225790e-04 3.653 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.384796e-04 3.623 0 0
Cell Cycle Checkpoints R-HSA-69620 2.379090e-04 3.624 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.636361e-04 3.579 0 0
DAG and IP3 signaling R-HSA-1489509 3.601789e-04 3.443 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 4.087810e-04 3.389 0 0
Oncogenic MAPK signaling R-HSA-6802957 4.261946e-04 3.370 0 0
Kinesins R-HSA-983189 4.243699e-04 3.372 0 0
Interleukin-37 signaling R-HSA-9008059 4.314278e-04 3.365 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.567522e-04 3.340 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 6.048692e-04 3.218 0 0
ChREBP activates metabolic gene expression R-HSA-163765 6.704987e-04 3.174 0 0
G alpha (12/13) signalling events R-HSA-416482 7.091210e-04 3.149 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 7.781925e-04 3.109 0 0
M Phase R-HSA-68886 7.800655e-04 3.108 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 7.214130e-04 3.142 0 0
Post NMDA receptor activation events R-HSA-438064 6.722783e-04 3.172 0 0
Calmodulin induced events R-HSA-111933 8.224833e-04 3.085 0 0
CaM pathway R-HSA-111997 8.224833e-04 3.085 0 0
Semaphorin interactions R-HSA-373755 7.282547e-04 3.138 0 0
Neurodegenerative Diseases R-HSA-8863678 8.472038e-04 3.072 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 8.472038e-04 3.072 0 0
Signaling by Hippo R-HSA-2028269 8.741213e-04 3.058 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.022464e-03 2.990 0 0
Activation of RAC1 R-HSA-428540 1.038516e-03 2.984 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.184797e-03 2.926 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.184797e-03 2.926 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.090393e-03 2.962 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.157380e-03 2.937 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.184797e-03 2.926 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.184797e-03 2.926 0 0
MAPK family signaling cascades R-HSA-5683057 1.319750e-03 2.880 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.361481e-03 2.866 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.438480e-03 2.842 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.552562e-03 2.809 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.543888e-03 2.811 0 0
TBC/RABGAPs R-HSA-8854214 1.654660e-03 2.781 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.661523e-03 2.779 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.991914e-03 2.701 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.249473e-03 2.648 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.249473e-03 2.648 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.423919e-03 2.615 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.427091e-03 2.615 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.424704e-03 2.615 0 0
Apoptosis R-HSA-109581 2.493041e-03 2.603 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.602773e-03 2.585 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.602773e-03 2.585 0 0
Signaling by RAS mutants R-HSA-6802949 2.881347e-03 2.540 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.881347e-03 2.540 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.881347e-03 2.540 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.881347e-03 2.540 0 0
TNF signaling R-HSA-75893 2.834768e-03 2.547 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.743766e-03 2.562 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.779914e-03 2.556 0 0
G2/M Transition R-HSA-69275 2.780531e-03 2.556 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.886969e-03 2.540 0 0
Resolution of D-Loop Structures R-HSA-5693537 3.213718e-03 2.493 0 0
Long-term potentiation R-HSA-9620244 3.390078e-03 2.470 0 0
Ca-dependent events R-HSA-111996 3.419424e-03 2.466 0 0
Muscle contraction R-HSA-397014 3.492843e-03 2.457 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.846659e-03 2.415 0 0
G2/M DNA damage checkpoint R-HSA-69473 3.931158e-03 2.405 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 4.151141e-03 2.382 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 4.555413e-03 2.341 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.340736e-03 2.272 0 0
Programmed Cell Death R-HSA-5357801 5.224111e-03 2.282 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 5.414216e-03 2.266 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 5.789759e-03 2.237 0 0
Membrane Trafficking R-HSA-199991 5.924680e-03 2.227 0 0
PIP3 activates AKT signaling R-HSA-1257604 6.131897e-03 2.212 0 0
Rab regulation of trafficking R-HSA-9007101 6.220746e-03 2.206 0 0
Signaling by RAF1 mutants R-HSA-9656223 6.875479e-03 2.163 0 0
Regulation of TNFR1 signaling R-HSA-5357905 6.738392e-03 2.171 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 6.911520e-03 2.160 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 6.973032e-03 2.157 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 6.973032e-03 2.157 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 6.973032e-03 2.157 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 6.973032e-03 2.157 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 7.019701e-03 2.154 0 0
Neurexins and neuroligins R-HSA-6794361 7.592341e-03 2.120 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 7.751586e-03 2.111 0 0
Recycling pathway of L1 R-HSA-437239 7.880106e-03 2.103 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 8.085527e-03 2.092 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 8.152362e-03 2.089 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 8.836708e-03 2.054 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 8.836708e-03 2.054 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 8.836708e-03 2.054 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 8.836708e-03 2.054 0 0
Signaling by VEGF R-HSA-194138 8.371704e-03 2.077 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 8.854081e-03 2.053 0 0
Centrosome maturation R-HSA-380287 8.983774e-03 2.047 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.029029e-03 2.044 0 0
Cellular response to heat stress R-HSA-3371556 9.114550e-03 2.040 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 9.170811e-03 2.038 0 0
RAF activation R-HSA-5673000 9.874175e-03 2.005 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 9.776608e-03 2.010 1 1
Signaling by Interleukins R-HSA-449147 9.244692e-03 2.034 0 0
L1CAM interactions R-HSA-373760 9.923453e-03 2.003 0 0
Signaling by ROBO receptors R-HSA-376176 1.033460e-02 1.986 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.068845e-02 1.971 0 0
Signaling by ALK in cancer R-HSA-9700206 1.068845e-02 1.971 0 0
TRIF-mediated programmed cell death R-HSA-2562578 1.141076e-02 1.943 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.109623e-02 1.955 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.163728e-02 1.934 0 0
TRP channels R-HSA-3295583 1.163977e-02 1.934 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 1.163977e-02 1.934 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 1.112008e-02 1.954 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.177596e-02 1.929 0 0
PLC beta mediated events R-HSA-112043 1.243672e-02 1.905 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.273737e-02 1.895 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.281220e-02 1.892 0 0
Separation of Sister Chromatids R-HSA-2467813 1.332517e-02 1.875 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.341534e-02 1.872 0 0
Notch-HLH transcription pathway R-HSA-350054 1.373853e-02 1.862 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.669544e-02 1.777 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.669544e-02 1.777 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.669544e-02 1.777 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.669544e-02 1.777 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.669544e-02 1.777 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.669544e-02 1.777 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.669544e-02 1.777 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.669544e-02 1.777 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.669544e-02 1.777 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.669544e-02 1.777 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.669544e-02 1.777 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.669544e-02 1.777 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.597999e-02 1.796 0 0
Germ layer formation at gastrulation R-HSA-9754189 1.609689e-02 1.793 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.593170e-02 1.798 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.593170e-02 1.798 0 0
Regulation of TP53 Activity R-HSA-5633007 1.567881e-02 1.805 1 0
The NLRP3 inflammasome R-HSA-844456 1.609689e-02 1.793 0 0
Cardiac conduction R-HSA-5576891 1.535349e-02 1.814 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.652887e-02 1.782 0 0
NrCAM interactions R-HSA-447038 1.477694e-02 1.830 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.652887e-02 1.782 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.673494e-02 1.776 0 0
PI Metabolism R-HSA-1483255 1.849506e-02 1.733 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 1.863411e-02 1.730 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.112057e-02 1.675 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.112057e-02 1.675 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.112057e-02 1.675 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.112057e-02 1.675 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.112057e-02 1.675 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.112057e-02 1.675 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.112057e-02 1.675 0 0
Signaling by LTK R-HSA-9842663 2.112057e-02 1.675 0 0
Nephrin family interactions R-HSA-373753 1.994978e-02 1.700 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.134308e-02 1.671 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 2.276632e-02 1.643 0 0
ARMS-mediated activation R-HSA-170984 2.297945e-02 1.639 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.297945e-02 1.639 0 0
ALK mutants bind TKIs R-HSA-9700645 2.297945e-02 1.639 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.304095e-02 1.637 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.304095e-02 1.637 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.196479e-02 1.658 0 0
Signaling by ERBB2 R-HSA-1227986 2.176689e-02 1.662 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.326263e-02 1.633 0 0
Diseases of programmed cell death R-HSA-9645723 2.190267e-02 1.660 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.314002e-02 1.636 1 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.390113e-02 1.622 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.164326e-02 1.665 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.212774e-02 1.655 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.196479e-02 1.658 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.297945e-02 1.639 0 0
Cytokine Signaling in Immune system R-HSA-1280215 2.305791e-02 1.637 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 2.391586e-02 1.621 0 0
FOXO-mediated transcription R-HSA-9614085 2.420229e-02 1.616 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 2.441678e-02 1.612 0 0
HDMs demethylate histones R-HSA-3214842 2.444731e-02 1.612 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.444731e-02 1.612 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.444731e-02 1.612 0 0
G-protein mediated events R-HSA-112040 2.516078e-02 1.599 0 0
Mitotic Anaphase R-HSA-68882 2.535704e-02 1.596 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.570237e-02 1.590 0 0
Neuronal System R-HSA-112316 2.614726e-02 1.583 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.632685e-02 1.580 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.940837e-02 1.532 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.940837e-02 1.532 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 2.727690e-02 1.564 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.727690e-02 1.564 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 2.727690e-02 1.564 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 2.727690e-02 1.564 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 2.914022e-02 1.536 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.677498e-02 1.572 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.688220e-02 1.571 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 2.962230e-02 1.528 0 0
Trafficking of AMPA receptors R-HSA-399719 2.806820e-02 1.552 0 0
Signaling by ERBB4 R-HSA-1236394 2.846509e-02 1.546 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.966996e-02 1.528 0 0
Diseases of DNA repair R-HSA-9675135 3.081712e-02 1.511 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 3.086710e-02 1.511 0 0
Tandem pore domain potassium channels R-HSA-1296346 3.086710e-02 1.511 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.154766e-02 1.501 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.270891e-02 1.485 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.314554e-02 1.480 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 3.318697e-02 1.479 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.564962e-02 1.448 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 3.564962e-02 1.448 0 0
PKA activation in glucagon signalling R-HSA-164378 3.564962e-02 1.448 0 0
Integrin signaling R-HSA-354192 3.786231e-02 1.422 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.551783e-02 1.450 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.698032e-02 1.432 0 0
Estrogen-dependent gene expression R-HSA-9018519 3.831149e-02 1.417 0 0
Eukaryotic Translation Elongation R-HSA-156842 3.458170e-02 1.461 0 0
Synaptic adhesion-like molecules R-HSA-8849932 3.564962e-02 1.448 0 0
PKA activation R-HSA-163615 3.564962e-02 1.448 0 0
Transport of connexons to the plasma membrane R-HSA-190872 3.564962e-02 1.448 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 3.786231e-02 1.422 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.786231e-02 1.422 0 0
Signaling by NTRKs R-HSA-166520 3.907463e-02 1.408 0 0
EPH-Ephrin signaling R-HSA-2682334 3.458170e-02 1.461 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.425834e-02 1.465 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.786231e-02 1.422 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.812115e-02 1.419 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.757841e-02 1.425 0 0
Co-stimulation by CD28 R-HSA-389356 3.921320e-02 1.407 0 0
ESR-mediated signaling R-HSA-8939211 3.934658e-02 1.405 0 0
Inflammasomes R-HSA-622312 4.005877e-02 1.397 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.026808e-02 1.395 0 0
Signaling by APC mutants R-HSA-4839744 4.026808e-02 1.395 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.026808e-02 1.395 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.026808e-02 1.395 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.026808e-02 1.395 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 4.056752e-02 1.392 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 4.056752e-02 1.392 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.190485e-02 1.378 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 4.212445e-02 1.375 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 4.288888e-02 1.368 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 4.355036e-02 1.361 0 0
Glycolysis R-HSA-70171 4.382085e-02 1.358 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 4.653368e-02 1.332 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.653368e-02 1.332 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 4.540821e-02 1.343 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 4.540821e-02 1.343 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 5.243432e-02 1.280 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 5.138334e-02 1.289 0 0
Co-inhibition by CTLA4 R-HSA-389513 5.138334e-02 1.289 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 4.920702e-02 1.308 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 4.496673e-02 1.347 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.579536e-02 1.339 0 0
Netrin-1 signaling R-HSA-373752 4.789418e-02 1.320 0 0
Homology Directed Repair R-HSA-5693538 5.157819e-02 1.288 0 0
Prolonged ERK activation events R-HSA-169893 5.243432e-02 1.280 0 0
Nuclear import of Rev protein R-HSA-180746 4.979238e-02 1.303 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 4.703323e-02 1.328 0 0
Ion homeostasis R-HSA-5578775 4.986474e-02 1.302 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 4.540821e-02 1.343 0 0
Generic Transcription Pathway R-HSA-212436 4.597222e-02 1.338 1 0
Interactions of Rev with host cellular proteins R-HSA-177243 5.211237e-02 1.283 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.789418e-02 1.320 0 0
Potassium Channels R-HSA-1296071 5.204516e-02 1.284 0 0
Cellular responses to stimuli R-HSA-8953897 4.769642e-02 1.322 0 0
Signaling by AMER1 mutants R-HSA-4839748 5.122938e-02 1.290 0 0
Signaling by AXIN mutants R-HSA-4839735 5.122938e-02 1.290 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 5.276724e-02 1.278 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.357240e-02 1.271 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 5.357240e-02 1.271 0 0
HSF1-dependent transactivation R-HSA-3371571 5.465290e-02 1.262 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 5.517224e-02 1.258 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 5.660481e-02 1.247 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 5.863690e-02 1.232 0 0
FLT3 Signaling R-HSA-9607240 5.863690e-02 1.232 0 0
Signaling by NOTCH1 R-HSA-1980143 5.980647e-02 1.223 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 6.014177e-02 1.221 0 0
Regulation by c-FLIP R-HSA-3371378 6.014177e-02 1.221 0 0
Dimerization of procaspase-8 R-HSA-69416 6.014177e-02 1.221 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 6.014177e-02 1.221 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 6.015656e-02 1.221 0 0
Organelle biogenesis and maintenance R-HSA-1852241 6.042742e-02 1.219 0 0
Breakdown of the nuclear lamina R-HSA-352238 6.073618e-02 1.217 0 0
Transport of glycerol from adipocytes to the liver by Aquaporins R-HSA-432030 6.073618e-02 1.217 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 6.073618e-02 1.217 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 6.132294e-02 1.212 0 0
Peptide chain elongation R-HSA-156902 6.296662e-02 1.201 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 6.365781e-02 1.196 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 6.376892e-02 1.195 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 6.376892e-02 1.195 0 0
Clathrin-mediated endocytosis R-HSA-8856828 6.382356e-02 1.195 0 0
RET signaling R-HSA-8853659 6.400096e-02 1.194 0 0
Chromatin modifying enzymes R-HSA-3247509 6.532831e-02 1.185 0 0
G2/M Checkpoints R-HSA-69481 6.548708e-02 1.184 0 0
MITF-M-dependent gene expression R-HSA-9856651 6.567131e-02 1.183 0 0
MAP2K and MAPK activation R-HSA-5674135 6.567855e-02 1.183 0 0
Negative regulation of MAPK pathway R-HSA-5675221 6.567855e-02 1.183 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 6.722530e-02 1.172 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 6.722530e-02 1.172 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 7.710015e-02 1.113 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.710015e-02 1.113 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 7.710015e-02 1.113 0 0
CASP8 activity is inhibited R-HSA-5218900 7.710015e-02 1.113 0 0
Interaction between L1 and Ankyrins R-HSA-445095 7.583755e-02 1.120 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 7.887223e-02 1.103 0 0
snRNP Assembly R-HSA-191859 6.691531e-02 1.174 0 0
Metabolism of non-coding RNA R-HSA-194441 6.691531e-02 1.174 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 7.786702e-02 1.109 0 0
NGF-stimulated transcription R-HSA-9031628 7.377877e-02 1.132 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 6.722530e-02 1.172 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 7.583755e-02 1.120 0 0
Regulation of necroptotic cell death R-HSA-5675482 7.887223e-02 1.103 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 6.971278e-02 1.157 0 0
Cilium Assembly R-HSA-5617833 7.106666e-02 1.148 0 0
Metalloprotease DUBs R-HSA-5689901 6.616078e-02 1.179 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.710015e-02 1.113 0 0
Specification of primordial germ cells R-HSA-9827857 7.511338e-02 1.124 0 0
DNA Double Strand Break Response R-HSA-5693606 7.913939e-02 1.102 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 8.058128e-02 1.094 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 8.260949e-02 1.083 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 8.473262e-02 1.072 0 0
RNA Polymerase II Transcription R-HSA-73857 8.615758e-02 1.065 1 0
Heme signaling R-HSA-9707616 8.744796e-02 1.058 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 8.824459e-02 1.054 0 0
Ephrin signaling R-HSA-3928664 8.824459e-02 1.054 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 8.835635e-02 1.054 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 8.866510e-02 1.052 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 8.866510e-02 1.052 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 8.868155e-02 1.052 0 0
Processing of DNA double-strand break ends R-HSA-5693607 8.908877e-02 1.050 0 0
ISG15 antiviral mechanism R-HSA-1169408 9.119471e-02 1.040 0 0
TRAIL signaling R-HSA-75158 9.136082e-02 1.039 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.167614e-02 1.038 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 9.167614e-02 1.038 0 0
Opioid Signalling R-HSA-111885 9.167614e-02 1.038 0 0
Gene expression (Transcription) R-HSA-74160 9.332700e-02 1.030 1 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 9.351771e-02 1.029 0 0
Physiological factors R-HSA-5578768 9.351771e-02 1.029 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 9.427445e-02 1.026 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.440977e-02 1.025 0 0
Cellular responses to stress R-HSA-2262752 9.441872e-02 1.025 0 0
MyD88-independent TLR4 cascade R-HSA-166166 9.472008e-02 1.024 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 9.472008e-02 1.024 0 0
Regulation of TP53 Expression R-HSA-6804754 9.921107e-02 1.003 0 0
DSCAM interactions R-HSA-376172 9.921107e-02 1.003 0 0
Regulation of cortical dendrite branching R-HSA-8985801 9.921107e-02 1.003 0 0
Potassium transport channels R-HSA-1296067 9.921107e-02 1.003 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 9.921107e-02 1.003 0 0
CREB phosphorylation R-HSA-199920 1.185227e-01 0.926 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 1.185227e-01 0.926 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.106327e-01 0.956 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.106327e-01 0.956 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.073843e-01 0.969 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.760541e-02 1.011 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 9.760541e-02 1.011 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 1.096830e-01 0.960 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.096830e-01 0.960 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.103610e-01 0.957 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 1.039487e-01 0.983 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 9.618054e-02 1.017 0 0
Rap1 signalling R-HSA-392517 1.025442e-01 0.989 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.142982e-01 0.942 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.170749e-01 0.932 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.096830e-01 0.960 0 0
IGF1R signaling cascade R-HSA-2428924 1.031258e-01 0.987 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.103610e-01 0.957 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.073843e-01 0.969 0 0
Hedgehog 'off' state R-HSA-5610787 1.074166e-01 0.969 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 1.115642e-01 0.952 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.179757e-01 0.928 0 0
NOD1/2 Signaling Pathway R-HSA-168638 9.917992e-02 1.004 0 0
Aggrephagy R-HSA-9646399 9.957253e-02 1.002 0 0
Activation of BH3-only proteins R-HSA-114452 1.096830e-01 0.960 0 0
Signaling by TGFBR3 R-HSA-9839373 1.088553e-01 0.963 0 0
Signaling by PTK6 R-HSA-8848021 9.508686e-02 1.022 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 9.508686e-02 1.022 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.106327e-01 0.956 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.096830e-01 0.960 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 9.618054e-02 1.017 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.154194e-01 0.938 0 0
Interleukin-12 signaling R-HSA-9020591 9.836914e-02 1.007 0 0
TGFBR3 expression R-HSA-9839394 1.214145e-01 0.916 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.221432e-01 0.913 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.225371e-01 0.912 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.225371e-01 0.912 0 0
Downstream signal transduction R-HSA-186763 1.225371e-01 0.912 0 0
Chromatin organization R-HSA-4839726 1.232956e-01 0.909 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.236786e-01 0.908 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.236786e-01 0.908 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.236786e-01 0.908 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.236786e-01 0.908 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.236786e-01 0.908 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.239566e-01 0.907 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.239566e-01 0.907 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.239566e-01 0.907 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.239566e-01 0.907 0 0
Activation of SMO R-HSA-5635838 1.291430e-01 0.889 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.291430e-01 0.889 0 0
Phase 4 - resting membrane potential R-HSA-5576886 1.291430e-01 0.889 0 0
Intraflagellar transport R-HSA-5620924 1.298442e-01 0.887 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.325544e-01 0.633 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.325544e-01 0.633 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.325544e-01 0.633 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.325544e-01 0.633 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.325544e-01 0.633 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.325544e-01 0.633 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.325544e-01 0.633 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.325544e-01 0.633 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.325544e-01 0.633 0 0
TWIK-related spinal cord K+ channel (TRESK) R-HSA-1299344 2.325544e-01 0.633 0 0
Defective Mismatch Repair Associated With MSH3 R-HSA-5632927 2.325544e-01 0.633 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.325544e-01 0.633 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.325544e-01 0.633 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.325544e-01 0.633 0 0
Defective SLC2A10 causes arterial tortuosity syndrome (ATS) R-HSA-5619068 2.325544e-01 0.633 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.425815e-01 0.846 0 0
MET activates PTPN11 R-HSA-8865999 1.425815e-01 0.846 0 0
TNFR1-mediated ceramide production R-HSA-5626978 1.890438e-01 0.723 0 0
HCN channels R-HSA-1296061 1.890438e-01 0.723 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.890438e-01 0.723 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 1.890438e-01 0.723 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.890438e-01 0.723 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 1.890438e-01 0.723 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 3.276954e-01 0.485 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.276954e-01 0.485 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 3.276954e-01 0.485 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.276954e-01 0.485 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.276954e-01 0.485 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.276954e-01 0.485 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 3.276954e-01 0.485 0 0
Intestinal infectious diseases R-HSA-8942233 3.276954e-01 0.485 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 3.276954e-01 0.485 0 0
XAV939 stabilizes AXIN R-HSA-5545619 3.276954e-01 0.485 0 0
IKBKB deficiency causes SCID R-HSA-5602636 3.276954e-01 0.485 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 3.276954e-01 0.485 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 3.276954e-01 0.485 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.276954e-01 0.485 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.276954e-01 0.485 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 3.276954e-01 0.485 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.276954e-01 0.485 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 3.276954e-01 0.485 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.371660e-01 0.625 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 2.371660e-01 0.625 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.371660e-01 0.625 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 2.371660e-01 0.625 0 0
G2 Phase R-HSA-68911 2.371660e-01 0.625 0 0
Type I hemidesmosome assembly R-HSA-446107 1.800698e-01 0.745 0 0
Activation of RAS in B cells R-HSA-1169092 1.800698e-01 0.745 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 1.645687e-01 0.784 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.135125e-01 0.671 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 2.135125e-01 0.671 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 2.858233e-01 0.544 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 2.858233e-01 0.544 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 2.858233e-01 0.544 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 2.858233e-01 0.544 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 2.858233e-01 0.544 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 2.858233e-01 0.544 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 2.858233e-01 0.544 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.858233e-01 0.544 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 2.858233e-01 0.544 0 0
Signaling by MAPK mutants R-HSA-9652817 2.858233e-01 0.544 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.110465e-01 0.386 0 0
Signaling by RAS GAP mutants R-HSA-9753510 4.110465e-01 0.386 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.110465e-01 0.386 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 4.110465e-01 0.386 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 4.110465e-01 0.386 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 1.489525e-01 0.827 0 0
Adenylate cyclase activating pathway R-HSA-170660 1.904285e-01 0.720 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.904285e-01 0.720 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 2.481316e-01 0.605 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 2.481316e-01 0.605 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.699514e-01 0.770 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.699514e-01 0.770 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.699514e-01 0.770 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.341441e-01 0.476 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 3.341441e-01 0.476 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 3.341441e-01 0.476 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 3.341441e-01 0.476 0 0
STAT5 Activation R-HSA-9645135 3.341441e-01 0.476 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 3.341441e-01 0.476 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 1.363330e-01 0.865 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.920190e-01 0.717 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.705221e-01 0.768 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 2.835108e-01 0.547 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 2.835108e-01 0.547 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 1.361458e-01 0.866 0 0
DCC mediated attractive signaling R-HSA-418885 2.454398e-01 0.610 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 2.454398e-01 0.610 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.454398e-01 0.610 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 2.150270e-01 0.668 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 2.150270e-01 0.668 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 1.686706e-01 0.773 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.504817e-01 0.823 0 0
Striated Muscle Contraction R-HSA-390522 1.655125e-01 0.781 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.859912e-01 0.731 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 2.388419e-01 0.622 0 0
Phosphorylation of the APC/C R-HSA-176412 2.741484e-01 0.562 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.741484e-01 0.562 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.741484e-01 0.562 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 3.192709e-01 0.496 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 3.192709e-01 0.496 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 3.192709e-01 0.496 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 3.192709e-01 0.496 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 3.814644e-01 0.419 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 3.814644e-01 0.419 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 3.814644e-01 0.419 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 3.814644e-01 0.419 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.814644e-01 0.419 0 0
Netrin mediated repulsion signals R-HSA-418886 3.814644e-01 0.419 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 3.814644e-01 0.419 0 0
SOS-mediated signalling R-HSA-112412 3.814644e-01 0.419 0 0
Recycling of eIF2:GDP R-HSA-72731 3.814644e-01 0.419 0 0
Disinhibition of SNARE formation R-HSA-114516 3.814644e-01 0.419 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 3.814644e-01 0.419 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 3.814644e-01 0.419 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.814644e-01 0.419 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.840682e-01 0.315 0 0
MET interacts with TNS proteins R-HSA-8875513 4.840682e-01 0.315 0 0
The IPAF inflammasome R-HSA-844623 4.840682e-01 0.315 0 0
Axonal growth stimulation R-HSA-209563 4.840682e-01 0.315 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 4.840682e-01 0.315 0 0
Defective ABCC2 causes DJS R-HSA-5679001 4.840682e-01 0.315 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 4.840682e-01 0.315 0 0
Defective CYP1B1 causes Glaucoma R-HSA-5579000 4.840682e-01 0.315 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.840682e-01 0.315 0 0
Defective HPRT1 disrupts guanine and hypoxanthine salvage R-HSA-9734281 4.840682e-01 0.315 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 4.840682e-01 0.315 0 0
Invadopodia formation R-HSA-8941237 4.840682e-01 0.315 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.840682e-01 0.315 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.616305e-01 0.791 0 0
Activation of the pre-replicative complex R-HSA-68962 2.040051e-01 0.690 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 2.040051e-01 0.690 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.633280e-01 0.580 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.633280e-01 0.580 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 2.633280e-01 0.580 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.633280e-01 0.580 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.759778e-01 0.755 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 1.975064e-01 0.704 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 1.975064e-01 0.704 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.033725e-01 0.518 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.033725e-01 0.518 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 2.524238e-01 0.598 0 0
MET activates RAS signaling R-HSA-8851805 3.550724e-01 0.450 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 3.550724e-01 0.450 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 2.883497e-01 0.540 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 2.883497e-01 0.540 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.715620e-01 0.766 0 0
Voltage gated Potassium channels R-HSA-1296072 2.317859e-01 0.635 0 0
Cristae formation R-HSA-8949613 2.744366e-01 0.562 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 3.329094e-01 0.478 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 4.272898e-01 0.369 0 0
FGFR1b ligand binding and activation R-HSA-190370 4.272898e-01 0.369 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 4.272898e-01 0.369 0 0
MET receptor recycling R-HSA-8875656 4.272898e-01 0.369 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 4.272898e-01 0.369 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 4.272898e-01 0.369 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.615769e-01 0.582 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 3.137732e-01 0.503 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 3.137732e-01 0.503 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.485441e-01 0.828 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.968783e-01 0.527 0 0
Telomere Extension By Telomerase R-HSA-171319 2.968783e-01 0.527 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 3.906172e-01 0.408 0 0
CD28 dependent Vav1 pathway R-HSA-389359 3.906172e-01 0.408 0 0
Formation of axial mesoderm R-HSA-9796292 3.906172e-01 0.408 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.817210e-01 0.550 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.647077e-01 0.783 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 3.196554e-01 0.495 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.134839e-01 0.671 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 3.022266e-01 0.520 0 0
Dual Incision in GG-NER R-HSA-5696400 3.022266e-01 0.520 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.740660e-01 0.759 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 2.724953e-01 0.565 0 0
Nucleosome assembly R-HSA-774815 2.724953e-01 0.565 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.263426e-01 0.645 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.786791e-01 0.748 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.786791e-01 0.748 0 0
PERK regulates gene expression R-HSA-381042 3.230236e-01 0.491 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 3.653100e-01 0.437 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 3.653100e-01 0.437 0 0
NRIF signals cell death from the nucleus R-HSA-205043 4.256481e-01 0.371 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 4.256481e-01 0.371 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 4.256481e-01 0.371 0 0
Interleukin-21 signaling R-HSA-9020958 4.712638e-01 0.327 0 0
WNT mediated activation of DVL R-HSA-201688 4.712638e-01 0.327 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.166969e-01 0.664 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.166969e-01 0.664 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 3.911798e-01 0.408 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 3.911798e-01 0.408 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 3.094478e-01 0.509 0 0
Spry regulation of FGF signaling R-HSA-1295596 4.599469e-01 0.337 0 0
SHC1 events in EGFR signaling R-HSA-180336 4.599469e-01 0.337 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 4.599469e-01 0.337 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 4.599469e-01 0.337 0 0
Signaling by EGFR in Cancer R-HSA-1643713 4.169664e-01 0.380 0 0
Pexophagy R-HSA-9664873 5.131413e-01 0.290 0 0
Folding of actin by CCT/TriC R-HSA-390450 5.131413e-01 0.290 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 4.425663e-01 0.354 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.714193e-01 0.430 0 0
mRNA 3'-end processing R-HSA-72187 3.990812e-01 0.399 0 0
Viral mRNA Translation R-HSA-192823 3.438691e-01 0.464 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 4.678846e-01 0.330 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 4.584089e-01 0.339 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 3.119187e-01 0.506 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 4.089518e-01 0.388 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 5.256587e-01 0.279 0 0
DAP12 signaling R-HSA-2424491 5.173402e-01 0.286 0 0
Regulation of RAS by GAPs R-HSA-5658442 5.010744e-01 0.300 0 0
Signaling by FGFR2 R-HSA-5654738 4.975327e-01 0.303 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.942607e-01 0.531 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 1.735942e-01 0.760 0 0
Signaling by FGFR3 R-HSA-5654741 1.705712e-01 0.768 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.080385e-01 0.682 0 0
Signaling by FGFR4 R-HSA-5654743 1.446656e-01 0.840 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.080385e-01 0.682 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 4.473395e-01 0.349 0 0
Mismatch Repair R-HSA-5358508 3.625688e-01 0.441 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 3.077011e-01 0.512 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 4.711415e-01 0.327 0 0
Specification of the neural plate border R-HSA-9834899 2.150270e-01 0.668 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.908815e-01 0.719 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 4.123151e-01 0.385 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 5.071005e-01 0.295 0 0
p75NTR signals via NF-kB R-HSA-193639 4.599469e-01 0.337 0 0
Chromosome Maintenance R-HSA-73886 4.250963e-01 0.372 0 0
Signaling by EGFR R-HSA-177929 2.329428e-01 0.633 0 0
G1/S Transition R-HSA-69206 3.961872e-01 0.402 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.481316e-01 0.605 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 3.137732e-01 0.503 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 3.095272e-01 0.509 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 4.933327e-01 0.307 0 0
RUNX2 regulates bone development R-HSA-8941326 3.440427e-01 0.463 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 3.329094e-01 0.478 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 2.228897e-01 0.652 0 0
Ribosome-associated quality control R-HSA-9948299 4.865130e-01 0.313 0 0
Signaling by FGFR1 R-HSA-5654736 3.429288e-01 0.465 0 0
Extension of Telomeres R-HSA-180786 5.268715e-01 0.278 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 1.482505e-01 0.829 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.411108e-01 0.850 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.705712e-01 0.768 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 3.329094e-01 0.478 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 4.169664e-01 0.380 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 5.256587e-01 0.279 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 4.678846e-01 0.330 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 4.901531e-01 0.310 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.489525e-01 0.827 0 0
Polo-like kinase mediated events R-HSA-156711 1.920190e-01 0.717 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 3.438521e-01 0.464 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 3.438521e-01 0.464 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.921868e-01 0.534 0 0
Signal attenuation R-HSA-74749 5.131413e-01 0.290 0 0
Cellular response to starvation R-HSA-9711097 3.883562e-01 0.411 0 0
Frs2-mediated activation R-HSA-170968 1.904285e-01 0.720 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 3.330511e-01 0.477 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.946640e-01 0.531 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.714193e-01 0.430 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 4.425663e-01 0.354 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 2.135125e-01 0.671 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 2.481316e-01 0.605 0 0
DARPP-32 events R-HSA-180024 3.196554e-01 0.495 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.919285e-01 0.308 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 3.199611e-01 0.495 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.384283e-01 0.859 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.478701e-01 0.830 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 4.572964e-01 0.340 0 0
Mitotic Prophase R-HSA-68875 1.821325e-01 0.740 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 5.256587e-01 0.279 0 0
Meiosis R-HSA-1500620 3.510520e-01 0.455 0 0
MHC class II antigen presentation R-HSA-2132295 2.090044e-01 0.680 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 1.890438e-01 0.723 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.371660e-01 0.625 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 2.858233e-01 0.544 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 3.814644e-01 0.419 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 4.272898e-01 0.369 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 3.137732e-01 0.503 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.866288e-01 0.543 0 0
Meiotic recombination R-HSA-912446 2.595681e-01 0.586 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.256481e-01 0.371 0 0
G-protein beta:gamma signalling R-HSA-397795 4.123151e-01 0.385 0 0
PI3K/AKT activation R-HSA-198203 5.131413e-01 0.290 0 0
Insulin receptor signalling cascade R-HSA-74751 3.580211e-01 0.446 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.572964e-01 0.340 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.317859e-01 0.635 0 0
Diseases of Immune System R-HSA-5260271 4.290027e-01 0.368 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 4.290027e-01 0.368 0 0
Protein folding R-HSA-391251 3.763750e-01 0.424 0 0
Signalling to ERKs R-HSA-187687 1.975064e-01 0.704 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.150270e-01 0.668 0 0
Activation of ATR in response to replication stress R-HSA-176187 4.123151e-01 0.385 0 0
Formation of definitive endoderm R-HSA-9823730 2.388419e-01 0.622 0 0
Interleukin-9 signaling R-HSA-8985947 4.272898e-01 0.369 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 5.082323e-01 0.294 0 0
Late Phase of HIV Life Cycle R-HSA-162599 4.574464e-01 0.340 0 0
Dopamine receptors R-HSA-390651 1.890438e-01 0.723 0 0
Adrenoceptors R-HSA-390696 1.800698e-01 0.745 0 0
cGMP effects R-HSA-418457 2.174599e-01 0.663 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.341441e-01 0.476 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 3.550724e-01 0.450 0 0
Regulation of IFNG signaling R-HSA-877312 3.550724e-01 0.450 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 3.906172e-01 0.408 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.963449e-01 0.707 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 3.253605e-01 0.488 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 4.878546e-01 0.312 0 0
Cardiogenesis R-HSA-9733709 4.123151e-01 0.385 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 4.901531e-01 0.310 0 0
Autophagy R-HSA-9612973 3.670943e-01 0.435 0 0
Selective autophagy R-HSA-9663891 2.215538e-01 0.655 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 3.416795e-01 0.466 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.197693e-01 0.658 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.381537e-01 0.471 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.363330e-01 0.865 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.887644e-01 0.724 0 0
TCF dependent signaling in response to WNT R-HSA-201681 4.284066e-01 0.368 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.521005e-01 0.818 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 3.550724e-01 0.450 0 0
Repression of WNT target genes R-HSA-4641265 3.550724e-01 0.450 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.317859e-01 0.635 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 2.185778e-01 0.660 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.311050e-01 0.480 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 4.791501e-01 0.320 0 0
HSF1 activation R-HSA-3371511 5.035637e-01 0.298 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.020830e-01 0.694 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.526329e-01 0.816 0 0
G1 Phase R-HSA-69236 5.326954e-01 0.274 0 0
Cyclin D associated events in G1 R-HSA-69231 5.326954e-01 0.274 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 5.225340e-01 0.282 0 0
GPER1 signaling R-HSA-9634597 2.131649e-01 0.671 0 0
Gastrulation R-HSA-9758941 2.950018e-01 0.530 0 0
Signaling by WNT in cancer R-HSA-4791275 1.361458e-01 0.866 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.616305e-01 0.791 0 0
Signaling by NOTCH R-HSA-157118 2.364948e-01 0.626 0 0
Macroautophagy R-HSA-1632852 5.215107e-01 0.283 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.810895e-01 0.742 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.002759e-01 0.398 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.904285e-01 0.720 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.686706e-01 0.773 0 0
Effects of PIP2 hydrolysis R-HSA-114508 1.655125e-01 0.781 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 3.192709e-01 0.496 0 0
Ca2+ activated K+ channels R-HSA-1296052 3.814644e-01 0.419 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.033725e-01 0.518 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 4.272898e-01 0.369 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.272898e-01 0.369 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 2.817210e-01 0.550 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 1.885037e-01 0.725 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.936202e-01 0.532 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 3.094478e-01 0.509 0 0
IRS-mediated signalling R-HSA-112399 3.601801e-01 0.443 0 0
Arachidonate production from DAG R-HSA-426048 5.131413e-01 0.290 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 4.033436e-01 0.394 0 0
DNA Repair R-HSA-73894 4.227037e-01 0.374 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.813880e-01 0.551 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.813880e-01 0.551 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.002759e-01 0.398 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 4.375326e-01 0.359 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 2.899580e-01 0.538 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 2.899580e-01 0.538 0 0
Gap junction trafficking R-HSA-190828 5.326954e-01 0.274 0 0
Hedgehog 'on' state R-HSA-5632684 4.737717e-01 0.324 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.813880e-01 0.551 0 0
Signaling by FGFR in disease R-HSA-1226099 2.948533e-01 0.530 0 0
Toll-like Receptor Cascades R-HSA-168898 3.616695e-01 0.442 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 3.033725e-01 0.518 0 0
Signaling by SCF-KIT R-HSA-1433557 1.446656e-01 0.840 0 0
Integration of energy metabolism R-HSA-163685 1.698478e-01 0.770 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 4.375326e-01 0.359 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 4.169664e-01 0.380 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.143839e-01 0.669 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 2.100600e-01 0.678 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.741484e-01 0.562 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 3.550724e-01 0.450 0 0
Regulation of KIT signaling R-HSA-1433559 4.256481e-01 0.371 0 0
Regulated Necrosis R-HSA-5218859 2.134839e-01 0.671 0 0
Signaling by FGFR3 in disease R-HSA-5655332 4.425663e-01 0.354 0 0
Mitochondrial biogenesis R-HSA-1592230 2.909515e-01 0.536 0 0
Host Interactions of HIV factors R-HSA-162909 4.623962e-01 0.335 0 0
FasL/ CD95L signaling R-HSA-75157 1.425815e-01 0.846 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 2.858233e-01 0.544 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.904285e-01 0.720 0 0
Formation of intermediate mesoderm R-HSA-9761174 2.481316e-01 0.605 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 2.174599e-01 0.663 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 3.192709e-01 0.496 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.814644e-01 0.419 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 3.077011e-01 0.512 0 0
Eukaryotic Translation Termination R-HSA-72764 2.459065e-01 0.609 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 4.599469e-01 0.337 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.291303e-01 0.483 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 4.933327e-01 0.307 0 0
Vesicle-mediated transport R-HSA-5653656 2.816745e-01 0.550 0 0
MTOR signalling R-HSA-165159 4.919285e-01 0.308 0 0
Signaling by Hedgehog R-HSA-5358351 1.353807e-01 0.868 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 3.911798e-01 0.408 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 3.652155e-01 0.437 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.462634e-01 0.461 0 0
Cellular Senescence R-HSA-2559583 2.609840e-01 0.583 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.401014e-01 0.854 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 3.550724e-01 0.450 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.392477e-01 0.856 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 2.615769e-01 0.582 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 4.599469e-01 0.337 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 4.599469e-01 0.337 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 4.928350e-01 0.307 0 0
Developmental Biology R-HSA-1266738 5.213839e-01 0.283 0 0
Transmission across Chemical Synapses R-HSA-112315 3.677325e-01 0.434 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.196554e-01 0.495 0 0
Gap junction assembly R-HSA-190861 3.022266e-01 0.520 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 2.077218e-01 0.683 0 0
Aquaporin-mediated transport R-HSA-445717 4.299037e-01 0.367 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.033725e-01 0.518 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 4.928350e-01 0.307 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 5.299643e-01 0.276 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.521005e-01 0.818 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.890438e-01 0.723 0 0
Transport of connexins along the secretory pathway R-HSA-190827 3.276954e-01 0.485 0 0
Mitochondrial transcription initiation R-HSA-163282 3.276954e-01 0.485 0 0
Co-stimulation by ICOS R-HSA-9927354 1.800698e-01 0.745 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 2.135125e-01 0.671 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 4.110465e-01 0.386 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 4.110465e-01 0.386 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 4.110465e-01 0.386 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.920190e-01 0.717 0 0
Ionotropic activity of kainate receptors R-HSA-451306 2.835108e-01 0.547 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 3.192709e-01 0.496 0 0
Sodium/Calcium exchangers R-HSA-425561 3.192709e-01 0.496 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 3.814644e-01 0.419 0 0
MET activates STAT3 R-HSA-8875791 4.840682e-01 0.315 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.840682e-01 0.315 0 0
FLT3 signaling in disease R-HSA-9682385 2.143839e-01 0.669 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.317859e-01 0.635 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 4.272898e-01 0.369 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 4.272898e-01 0.369 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 2.222223e-01 0.653 0 0
Platelet calcium homeostasis R-HSA-418360 3.196554e-01 0.495 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 2.724953e-01 0.565 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 2.417745e-01 0.617 0 0
Smooth Muscle Contraction R-HSA-445355 2.921868e-01 0.534 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.656505e-01 0.781 0 0
PI3K Cascade R-HSA-109704 3.621717e-01 0.441 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 4.290027e-01 0.368 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 4.647107e-01 0.333 0 0
Interferon Signaling R-HSA-913531 2.829369e-01 0.548 0 0
Interleukin-2 family signaling R-HSA-451927 1.759778e-01 0.755 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 2.529649e-01 0.597 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.395095e-01 0.621 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.361458e-01 0.866 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.254780e-01 0.487 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 3.414849e-01 0.467 0 0
Amine ligand-binding receptors R-HSA-375280 3.835992e-01 0.416 0 0
Signaling by FGFR4 in disease R-HSA-5655291 4.256481e-01 0.371 0 0
Platelet activation, signaling and aggregation R-HSA-76002 3.889764e-01 0.410 0 0
Sensory processing of sound R-HSA-9659379 1.852706e-01 0.732 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 3.911798e-01 0.408 0 0
Interleukin-6 signaling R-HSA-1059683 3.906172e-01 0.408 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 5.090437e-01 0.293 0 0
Protein methylation R-HSA-8876725 4.599469e-01 0.337 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.391158e-01 0.470 0 0
Differentiation of T cells R-HSA-9945266 4.933327e-01 0.307 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 4.933327e-01 0.307 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 3.917940e-01 0.407 0 0
Signaling by NOTCH3 R-HSA-9012852 2.185778e-01 0.660 0 0
Reproduction R-HSA-1474165 4.687491e-01 0.329 0 0
Selenocysteine synthesis R-HSA-2408557 2.355782e-01 0.628 0 0
Oncogene Induced Senescence R-HSA-2559585 4.811358e-01 0.318 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 3.595814e-01 0.444 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.883497e-01 0.540 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 4.215673e-01 0.375 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 5.071005e-01 0.295 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.329428e-01 0.633 0 0
MAP kinase activation R-HSA-450294 4.299037e-01 0.367 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.965011e-01 0.528 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.482505e-01 0.829 0 0
OAS antiviral response R-HSA-8983711 1.645687e-01 0.784 0 0
Nef and signal transduction R-HSA-164944 3.341441e-01 0.476 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.655125e-01 0.781 0 0
Signal regulatory protein family interactions R-HSA-391160 4.256481e-01 0.371 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 4.712638e-01 0.327 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 4.599469e-01 0.337 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 4.033436e-01 0.394 0 0
Signaling by Erythropoietin R-HSA-9006335 4.928350e-01 0.307 0 0
Signaling by KIT in disease R-HSA-9669938 3.137732e-01 0.503 0 0
Interleukin-1 family signaling R-HSA-446652 1.951732e-01 0.710 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.557554e-01 0.449 0 0
Signaling by TGFB family members R-HSA-9006936 4.097949e-01 0.387 0 0
mTORC1-mediated signalling R-HSA-166208 3.137732e-01 0.503 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.739114e-01 0.427 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.504817e-01 0.823 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 2.883497e-01 0.540 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 3.625688e-01 0.441 0 0
Tie2 Signaling R-HSA-210993 1.920190e-01 0.717 0 0
Interleukin-15 signaling R-HSA-8983432 3.550724e-01 0.450 0 0
Ion transport by P-type ATPases R-HSA-936837 3.580211e-01 0.446 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.402008e-01 0.468 0 0
Oligomerization of connexins into connexons R-HSA-190704 3.276954e-01 0.485 0 0
Transcription from mitochondrial promoters R-HSA-75944 4.110465e-01 0.386 0 0
Synthesis of PI R-HSA-1483226 2.835108e-01 0.547 0 0
Formation of the anterior neural plate R-HSA-9823739 2.454398e-01 0.610 0 0
Regulation of gene expression in beta cells R-HSA-210745 1.859912e-01 0.731 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.616305e-01 0.791 0 0
Signaling by ALK R-HSA-201556 2.679610e-01 0.572 0 0
G0 and Early G1 R-HSA-1538133 3.890902e-01 0.410 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 4.506017e-01 0.346 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 5.131413e-01 0.290 0 0
SARS-CoV-1-host interactions R-HSA-9692914 4.949397e-01 0.305 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 3.906172e-01 0.408 0 0
Glucose metabolism R-HSA-70326 1.571752e-01 0.804 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 2.633280e-01 0.580 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.454398e-01 0.610 0 0
Histamine receptors R-HSA-390650 4.840682e-01 0.315 0 0
Stimuli-sensing channels R-HSA-2672351 5.216621e-01 0.283 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 4.110465e-01 0.386 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 2.741484e-01 0.562 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.814644e-01 0.419 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.866288e-01 0.543 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.056113e-01 0.515 0 0
PKR-mediated signaling R-HSA-9833482 2.812815e-01 0.551 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 5.131413e-01 0.290 0 0
Unfolded Protein Response (UPR) R-HSA-381119 4.113557e-01 0.386 0 0
Platelet sensitization by LDL R-HSA-432142 3.625688e-01 0.441 0 0
GP1b-IX-V activation signalling R-HSA-430116 4.712638e-01 0.327 0 0
Interleukin-12 family signaling R-HSA-447115 1.433224e-01 0.844 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 4.712638e-01 0.327 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 4.584089e-01 0.339 0 0
Signaling by Leptin R-HSA-2586552 5.131413e-01 0.290 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.899580e-01 0.538 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 4.712638e-01 0.327 0 0
Regulation of beta-cell development R-HSA-186712 2.780258e-01 0.556 0 0
Influenza Infection R-HSA-168255 2.524307e-01 0.598 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.633280e-01 0.580 0 0
Interleukin receptor SHC signaling R-HSA-912526 5.343570e-01 0.272 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 5.343570e-01 0.272 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.343570e-01 0.272 0 0
Syndecan interactions R-HSA-3000170 5.343570e-01 0.272 0 0
Growth hormone receptor signaling R-HSA-982772 5.343570e-01 0.272 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 5.384864e-01 0.269 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 5.384864e-01 0.269 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 5.388989e-01 0.268 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 5.388989e-01 0.268 0 0
mRNA Splicing - Major Pathway R-HSA-72163 5.397692e-01 0.268 0 0
EGFR downregulation R-HSA-182971 5.413316e-01 0.267 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 5.413316e-01 0.267 0 0
HIV Life Cycle R-HSA-162587 5.413643e-01 0.267 0 0
GABA receptor activation R-HSA-977443 5.444705e-01 0.264 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 5.444705e-01 0.264 0 0
MET promotes cell motility R-HSA-8875878 5.472982e-01 0.262 0 0
TCR signaling R-HSA-202403 5.479961e-01 0.261 0 0
Regulation of gap junction activity R-HSA-191650 5.480400e-01 0.261 0 0
NADE modulates death signalling R-HSA-205025 5.480400e-01 0.261 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 5.480400e-01 0.261 0 0
ATP sensitive Potassium channels R-HSA-1296025 5.480400e-01 0.261 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 5.480400e-01 0.261 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.480400e-01 0.261 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 5.480400e-01 0.261 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.480400e-01 0.261 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 5.480400e-01 0.261 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.480400e-01 0.261 0 0
MDK and PTN in ALK signaling R-HSA-9851151 5.480400e-01 0.261 0 0
Sensory perception of sour taste R-HSA-9729555 5.480400e-01 0.261 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 5.480400e-01 0.261 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 5.480400e-01 0.261 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.480400e-01 0.261 0 0
Cell-Cell communication R-HSA-1500931 5.486977e-01 0.261 0 0
Deubiquitination R-HSA-5688426 5.488175e-01 0.261 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 5.525897e-01 0.258 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 5.527662e-01 0.257 0 0
FGFR2b ligand binding and activation R-HSA-190377 5.527662e-01 0.257 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 5.527662e-01 0.257 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 5.527662e-01 0.257 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 5.527662e-01 0.257 0 0
Formation of the posterior neural plate R-HSA-9832991 5.527662e-01 0.257 0 0
Bicarbonate transporters R-HSA-425381 5.527662e-01 0.257 0 0
PECAM1 interactions R-HSA-210990 5.527662e-01 0.257 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 5.527662e-01 0.257 0 0
Interleukin-2 signaling R-HSA-9020558 5.527662e-01 0.257 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 5.568095e-01 0.254 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 5.568095e-01 0.254 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 5.568095e-01 0.254 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 5.568095e-01 0.254 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 5.568095e-01 0.254 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 5.568095e-01 0.254 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 5.568095e-01 0.254 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 5.573900e-01 0.254 0 0
Deadenylation of mRNA R-HSA-429947 5.608384e-01 0.251 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 5.608384e-01 0.251 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 5.608384e-01 0.251 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.618130e-01 0.250 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 5.618130e-01 0.250 0 0
Ion channel transport R-HSA-983712 5.661301e-01 0.247 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 5.721072e-01 0.243 0 0
mRNA Splicing R-HSA-72172 5.724074e-01 0.242 0 0
Inositol phosphate metabolism R-HSA-1483249 5.738405e-01 0.241 0 0
NCAM signaling for neurite out-growth R-HSA-375165 5.788735e-01 0.237 0 0
Signaling by PDGF R-HSA-186797 5.788735e-01 0.237 0 0
tRNA processing in the nucleus R-HSA-6784531 5.788735e-01 0.237 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.820624e-01 0.235 0 0
Interleukin-17 signaling R-HSA-448424 5.820624e-01 0.235 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 5.864779e-01 0.232 0 0
Interleukin-7 signaling R-HSA-1266695 5.864779e-01 0.232 0 0
Formation of the nephric duct R-HSA-9830364 5.864779e-01 0.232 0 0
PTEN Regulation R-HSA-6807070 5.865741e-01 0.232 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 5.866977e-01 0.232 0 0
GAB1 signalosome R-HSA-180292 5.866977e-01 0.232 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 5.866977e-01 0.232 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 5.875419e-01 0.231 0 0
Signaling by WNT R-HSA-195721 5.881533e-01 0.231 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 5.892198e-01 0.230 0 0
Attenuation phase R-HSA-3371568 5.892198e-01 0.230 0 0
Generation of second messenger molecules R-HSA-202433 5.892198e-01 0.230 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 5.900533e-01 0.229 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 5.900533e-01 0.229 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 5.900533e-01 0.229 0 0
ERKs are inactivated R-HSA-202670 5.900533e-01 0.229 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.900533e-01 0.229 0 0
NF-kB is activated and signals survival R-HSA-209560 5.900533e-01 0.229 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 5.900533e-01 0.229 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 5.900533e-01 0.229 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 5.900533e-01 0.229 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 5.900533e-01 0.229 0 0
Integration of provirus R-HSA-162592 5.900533e-01 0.229 0 0
G alpha (z) signalling events R-HSA-418597 5.933782e-01 0.227 0 0
HATs acetylate histones R-HSA-3214847 5.937672e-01 0.226 0 0
Cellular response to chemical stress R-HSA-9711123 5.944065e-01 0.226 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 5.951478e-01 0.225 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 5.956286e-01 0.225 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 6.002218e-01 0.222 0 0
XBP1(S) activates chaperone genes R-HSA-381038 6.025190e-01 0.220 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 6.040829e-01 0.219 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 6.040829e-01 0.219 0 0
IRS activation R-HSA-74713 6.040829e-01 0.219 0 0
Defective CYP17A1 causes AH5 R-HSA-5579028 6.040829e-01 0.219 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 6.040829e-01 0.219 0 0
PTK6 Down-Regulation R-HSA-8849472 6.040829e-01 0.219 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 6.040829e-01 0.219 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.040829e-01 0.219 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 6.040829e-01 0.219 0 0
Co-inhibition by BTLA R-HSA-9927353 6.040829e-01 0.219 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 6.040829e-01 0.219 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 6.040829e-01 0.219 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 6.079034e-01 0.216 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 6.094022e-01 0.215 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 6.096661e-01 0.215 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 6.096661e-01 0.215 0 0
Miscellaneous transport and binding events R-HSA-5223345 6.096661e-01 0.215 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 6.098833e-01 0.215 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 6.112222e-01 0.214 0 0
Myogenesis R-HSA-525793 6.112222e-01 0.214 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 6.112222e-01 0.214 0 0
S Phase R-HSA-69242 6.113036e-01 0.214 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 6.134863e-01 0.212 0 0
Signaling by MET R-HSA-6806834 6.150462e-01 0.211 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.152610e-01 0.211 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.152610e-01 0.211 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.152610e-01 0.211 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.152610e-01 0.211 0 0
STING mediated induction of host immune responses R-HSA-1834941 6.152610e-01 0.211 0 0
Maturation of nucleoprotein R-HSA-9694631 6.152610e-01 0.211 0 0
p75NTR recruits signalling complexes R-HSA-209543 6.249730e-01 0.204 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 6.249730e-01 0.204 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 6.249730e-01 0.204 0 0
IRAK1 recruits IKK complex R-HSA-937039 6.249730e-01 0.204 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 6.249730e-01 0.204 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 6.249730e-01 0.204 0 0
Scavenging by Class F Receptors R-HSA-3000484 6.249730e-01 0.204 0 0
GRB2 events in EGFR signaling R-HSA-179812 6.249730e-01 0.204 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 6.249730e-01 0.204 0 0
Phospholipid metabolism R-HSA-1483257 6.253360e-01 0.204 0 0
Gap junction trafficking and regulation R-HSA-157858 6.280871e-01 0.202 0 0
Ca2+ pathway R-HSA-4086398 6.287472e-01 0.202 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.290239e-01 0.201 0 0
HIV Transcription Initiation R-HSA-167161 6.290239e-01 0.201 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.290239e-01 0.201 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 6.310863e-01 0.200 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 6.318013e-01 0.199 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 6.350301e-01 0.197 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 6.350301e-01 0.197 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 6.350301e-01 0.197 0 0
HIV Infection R-HSA-162906 6.409137e-01 0.193 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.424591e-01 0.192 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 6.424591e-01 0.192 0 0
Protein hydroxylation R-HSA-9629569 6.424591e-01 0.192 0 0
Dual incision in TC-NER R-HSA-6782135 6.445043e-01 0.191 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 6.480598e-01 0.188 0 0
Activation of GABAB receptors R-HSA-991365 6.480598e-01 0.188 0 0
GABA B receptor activation R-HSA-977444 6.480598e-01 0.188 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 6.480598e-01 0.188 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 6.531795e-01 0.185 0 0
Plus-strand DNA synthesis R-HSA-164525 6.531795e-01 0.185 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 6.531795e-01 0.185 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 6.531795e-01 0.185 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.531795e-01 0.185 0 0
PDE3B signalling R-HSA-165160 6.531795e-01 0.185 0 0
PKB-mediated events R-HSA-109703 6.531795e-01 0.185 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 6.531795e-01 0.185 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.531795e-01 0.185 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 6.531795e-01 0.185 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 6.531795e-01 0.185 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 6.531795e-01 0.185 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.531795e-01 0.185 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 6.531795e-01 0.185 0 0
Pentose phosphate pathway disease R-HSA-6791465 6.531795e-01 0.185 0 0
Phosphorylation of Emi1 R-HSA-176417 6.531795e-01 0.185 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.531795e-01 0.185 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.531795e-01 0.185 0 0
Ceramide signalling R-HSA-193681 6.531795e-01 0.185 0 0
Formation of the Editosome R-HSA-75094 6.531795e-01 0.185 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.531795e-01 0.185 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.531795e-01 0.185 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 6.531795e-01 0.185 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.531795e-01 0.185 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 6.531795e-01 0.185 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 6.531795e-01 0.185 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 6.531795e-01 0.185 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 6.531795e-01 0.185 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 6.531795e-01 0.185 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.531795e-01 0.185 0 0
Acetylcholine binding and downstream events R-HSA-181431 6.575391e-01 0.182 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 6.575391e-01 0.182 0 0
FGFR2c ligand binding and activation R-HSA-190375 6.575391e-01 0.182 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 6.575391e-01 0.182 0 0
FGFR1c ligand binding and activation R-HSA-190373 6.575391e-01 0.182 0 0
Chylomicron remodeling R-HSA-8963901 6.575391e-01 0.182 0 0
FGFR4 ligand binding and activation R-HSA-190322 6.575391e-01 0.182 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 6.575391e-01 0.182 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 6.575391e-01 0.182 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 6.575391e-01 0.182 0 0
FGFR3 mutant receptor activation R-HSA-2033514 6.575391e-01 0.182 0 0
Maturation of nucleoprotein R-HSA-9683610 6.575391e-01 0.182 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 6.575391e-01 0.182 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 6.578719e-01 0.182 0 0
Pyroptosis R-HSA-5620971 6.578719e-01 0.182 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 6.664895e-01 0.176 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 6.682708e-01 0.175 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.682708e-01 0.175 0 0
ERK/MAPK targets R-HSA-198753 6.682708e-01 0.175 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 6.682708e-01 0.175 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 6.714671e-01 0.173 0 0
G1/S-Specific Transcription R-HSA-69205 6.717084e-01 0.173 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 6.717084e-01 0.173 0 0
RNA Polymerase III Transcription R-HSA-74158 6.717084e-01 0.173 0 0
Triglyceride catabolism R-HSA-163560 6.717084e-01 0.173 0 0
GPVI-mediated activation cascade R-HSA-114604 6.717084e-01 0.173 0 0
RAB geranylgeranylation R-HSA-8873719 6.764604e-01 0.170 0 0
Late endosomal microautophagy R-HSA-9615710 6.797281e-01 0.168 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 6.797281e-01 0.168 0 0
IRE1alpha activates chaperones R-HSA-381070 6.836017e-01 0.165 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.847972e-01 0.164 0 0
Removal of the Flap Intermediate R-HSA-69166 6.877983e-01 0.163 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 6.877983e-01 0.163 0 0
FGFR3c ligand binding and activation R-HSA-190372 6.877983e-01 0.163 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 6.877983e-01 0.163 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 6.877983e-01 0.163 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 6.877983e-01 0.163 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 6.877983e-01 0.163 0 0
Platelet degranulation R-HSA-114608 6.925977e-01 0.160 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 6.926913e-01 0.159 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 6.926913e-01 0.159 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 6.926913e-01 0.159 0 0
Assembly Of The HIV Virion R-HSA-175474 6.926913e-01 0.159 0 0
Platelet homeostasis R-HSA-418346 6.939283e-01 0.159 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 6.958685e-01 0.157 0 0
Regulation of PTEN stability and activity R-HSA-8948751 6.958685e-01 0.157 0 0
Signaling by Insulin receptor R-HSA-74752 6.961223e-01 0.157 0 0
Uncoating of the HIV Virion R-HSA-162585 6.961901e-01 0.157 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.961901e-01 0.157 0 0
Hydrolysis of LPE R-HSA-1483152 6.961901e-01 0.157 0 0
MET Receptor Activation R-HSA-6806942 6.961901e-01 0.157 0 0
Neurofascin interactions R-HSA-447043 6.961901e-01 0.157 0 0
Abacavir transmembrane transport R-HSA-2161517 6.961901e-01 0.157 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.961901e-01 0.157 0 0
Signaling by LTK in cancer R-HSA-9842640 6.961901e-01 0.157 0 0
NADPH regeneration R-HSA-389542 6.961901e-01 0.157 0 0
CREB3 factors activate genes R-HSA-8874211 6.961901e-01 0.157 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.014713e-01 0.154 0 0
Gene Silencing by RNA R-HSA-211000 7.053613e-01 0.152 0 0
Mitochondrial protein import R-HSA-1268020 7.065900e-01 0.151 0 0
Epigenetic regulation of gene expression R-HSA-212165 7.149427e-01 0.146 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.157295e-01 0.145 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 7.157295e-01 0.145 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.157295e-01 0.145 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 7.158218e-01 0.145 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 7.158218e-01 0.145 0 0
Translesion synthesis by REV1 R-HSA-110312 7.158218e-01 0.145 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 7.158218e-01 0.145 0 0
Processive synthesis on the lagging strand R-HSA-69183 7.158218e-01 0.145 0 0
Erythropoietin activates RAS R-HSA-9027284 7.158218e-01 0.145 0 0
FGFR3 ligand binding and activation R-HSA-190239 7.158218e-01 0.145 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 7.158218e-01 0.145 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 7.158218e-01 0.145 0 0
Other semaphorin interactions R-HSA-416700 7.158218e-01 0.145 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 7.158218e-01 0.145 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 7.165879e-01 0.145 0 0
Regulation of mitotic cell cycle R-HSA-453276 7.165879e-01 0.145 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 7.180043e-01 0.144 0 0
Interleukin-1 signaling R-HSA-9020702 7.181882e-01 0.144 0 0
Budding and maturation of HIV virion R-HSA-162588 7.204504e-01 0.142 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.204504e-01 0.142 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.204504e-01 0.142 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 7.244771e-01 0.140 0 0
Stabilization of p53 R-HSA-69541 7.268647e-01 0.139 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 7.268647e-01 0.139 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 7.338691e-01 0.134 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.338691e-01 0.134 0 0
DAG1 core M1 glycosylations R-HSA-8932506 7.338691e-01 0.134 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 7.338691e-01 0.134 0 0
FGFR3b ligand binding and activation R-HSA-190371 7.338691e-01 0.134 0 0
mRNA Editing: C to U Conversion R-HSA-72200 7.338691e-01 0.134 0 0
PTK6 Expression R-HSA-8849473 7.338691e-01 0.134 0 0
Cysteine formation from homocysteine R-HSA-1614603 7.338691e-01 0.134 0 0
VLDL clearance R-HSA-8964046 7.338691e-01 0.134 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 7.338691e-01 0.134 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 7.338691e-01 0.134 0 0
Regulation of PTEN localization R-HSA-8948747 7.338691e-01 0.134 0 0
CHL1 interactions R-HSA-447041 7.338691e-01 0.134 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 7.338691e-01 0.134 0 0
Maturation of replicase proteins R-HSA-9694301 7.338691e-01 0.134 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 7.338921e-01 0.134 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.374061e-01 0.132 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.374061e-01 0.132 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 7.374061e-01 0.132 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 7.374061e-01 0.132 0 0
Interleukin-20 family signaling R-HSA-8854691 7.374061e-01 0.132 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.393195e-01 0.131 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 7.410832e-01 0.130 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.410832e-01 0.130 0 0
Translesion synthesis by POLI R-HSA-5656121 7.416988e-01 0.130 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 7.416988e-01 0.130 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 7.416988e-01 0.130 0 0
Negative regulation of FLT3 R-HSA-9706369 7.416988e-01 0.130 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 7.416988e-01 0.130 0 0
Atorvastatin ADME R-HSA-9754706 7.416988e-01 0.130 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 7.436870e-01 0.129 0 0
HIV Transcription Elongation R-HSA-167169 7.436870e-01 0.129 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 7.436870e-01 0.129 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 7.443873e-01 0.128 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 7.540085e-01 0.123 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 7.540085e-01 0.123 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 7.540085e-01 0.123 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 7.540762e-01 0.123 0 0
Hemostasis R-HSA-109582 7.552779e-01 0.122 0 0
Nuclear RNA decay R-HSA-9930044 7.572068e-01 0.121 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 7.572068e-01 0.121 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 7.572068e-01 0.121 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 7.577511e-01 0.120 0 0
Interleukin-6 family signaling R-HSA-6783589 7.577511e-01 0.120 0 0
Complex III assembly R-HSA-9865881 7.577511e-01 0.120 0 0
ER to Golgi Anterograde Transport R-HSA-199977 7.581835e-01 0.120 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 7.597323e-01 0.119 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 7.655304e-01 0.116 0 0
Translesion synthesis by POLK R-HSA-5655862 7.655304e-01 0.116 0 0
Phase 2 - plateau phase R-HSA-5576893 7.655304e-01 0.116 0 0
Passive transport by Aquaporins R-HSA-432047 7.655304e-01 0.116 0 0
Disorders of Developmental Biology R-HSA-9675151 7.655304e-01 0.116 0 0
Galactose catabolism R-HSA-70370 7.655304e-01 0.116 0 0
Synthesis of PG R-HSA-1483148 7.655304e-01 0.116 0 0
Reverse Transcription of HIV RNA R-HSA-162589 7.668770e-01 0.115 0 0
Minus-strand DNA synthesis R-HSA-164516 7.668770e-01 0.115 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 7.668770e-01 0.115 0 0
RSK activation R-HSA-444257 7.668770e-01 0.115 0 0
DAG1 core M2 glycosylations R-HSA-8932504 7.668770e-01 0.115 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.668770e-01 0.115 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.668770e-01 0.115 0 0
Formation of annular gap junctions R-HSA-196025 7.668770e-01 0.115 0 0
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597 7.668770e-01 0.115 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.668770e-01 0.115 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 7.668770e-01 0.115 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.668770e-01 0.115 0 0
Fructose biosynthesis R-HSA-5652227 7.668770e-01 0.115 0 0
Nucleotide salvage defects R-HSA-9734207 7.668770e-01 0.115 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.668770e-01 0.115 0 0
Alpha-defensins R-HSA-1462054 7.668770e-01 0.115 0 0
Sodium/Proton exchangers R-HSA-425986 7.668770e-01 0.115 0 0
Nucleotide Excision Repair R-HSA-5696398 7.714312e-01 0.113 0 0
Metabolism of RNA R-HSA-8953854 7.718389e-01 0.112 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 7.733116e-01 0.112 0 0
Kidney development R-HSA-9830369 7.735917e-01 0.111 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 7.741289e-01 0.111 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 7.741289e-01 0.111 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 7.750092e-01 0.111 0 0
Signaling by FGFR R-HSA-190236 7.750318e-01 0.111 0 0
Regulation of insulin secretion R-HSA-422356 7.750318e-01 0.111 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 7.768023e-01 0.110 0 0
SARS-CoV-2 Infection R-HSA-9694516 7.771883e-01 0.109 0 0
Signaling by FGFR2 in disease R-HSA-5655253 7.776933e-01 0.109 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 7.786423e-01 0.109 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 7.786423e-01 0.109 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 7.788691e-01 0.109 0 0
Transcription of the HIV genome R-HSA-167172 7.855548e-01 0.105 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 7.862127e-01 0.104 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 7.874259e-01 0.104 0 0
Sulfide oxidation to sulfate R-HSA-1614517 7.874259e-01 0.104 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 7.874259e-01 0.104 0 0
Interferon gamma signaling R-HSA-877300 7.893776e-01 0.103 0 0
Signaling by NOTCH2 R-HSA-1980145 7.901071e-01 0.102 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 7.901071e-01 0.102 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 7.901071e-01 0.102 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.910232e-01 0.102 0 0
SARS-CoV-1 Infection R-HSA-9678108 7.936054e-01 0.100 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 7.946035e-01 0.100 0 0
Lipophagy R-HSA-9613354 7.957926e-01 0.099 0 0
Gap junction degradation R-HSA-190873 7.957926e-01 0.099 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.957926e-01 0.099 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.957926e-01 0.099 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.957926e-01 0.099 0 0
Unwinding of DNA R-HSA-176974 7.957926e-01 0.099 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 7.957926e-01 0.099 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.957926e-01 0.099 0 0
Degradation of GABA R-HSA-916853 7.957926e-01 0.099 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.957926e-01 0.099 0 0
Calcineurin activates NFAT R-HSA-2025928 7.957926e-01 0.099 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.957926e-01 0.099 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.957926e-01 0.099 0 0
mRNA Editing R-HSA-75072 7.957926e-01 0.099 0 0
Interleukin-1 processing R-HSA-448706 7.957926e-01 0.099 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.957926e-01 0.099 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.957926e-01 0.099 0 0
Cellular response to mitochondrial stress R-HSA-9840373 7.957926e-01 0.099 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 7.957926e-01 0.099 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 7.998303e-01 0.097 0 0
RNA Polymerase I Transcription R-HSA-73864 8.008075e-01 0.096 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 8.037322e-01 0.095 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.037322e-01 0.095 0 0
Neutrophil degranulation R-HSA-6798695 8.044257e-01 0.095 0 0
Formation of paraxial mesoderm R-HSA-9793380 8.054920e-01 0.094 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.070593e-01 0.093 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 8.074989e-01 0.093 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 8.074989e-01 0.093 0 0
Activated point mutants of FGFR2 R-HSA-2033519 8.074989e-01 0.093 0 0
FGFR1 ligand binding and activation R-HSA-190242 8.074989e-01 0.093 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 8.074989e-01 0.093 0 0
Apoptotic factor-mediated response R-HSA-111471 8.074989e-01 0.093 0 0
Nephron development R-HSA-9831926 8.074989e-01 0.093 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 8.074989e-01 0.093 0 0
DNA Replication Pre-Initiation R-HSA-69002 8.087079e-01 0.092 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 8.112031e-01 0.091 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 8.112031e-01 0.091 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.158322e-01 0.088 0 0
Meiotic synapsis R-HSA-1221632 8.158322e-01 0.088 0 0
RMTs methylate histone arginines R-HSA-3214858 8.163631e-01 0.088 0 0
DAP12 interactions R-HSA-2172127 8.163631e-01 0.088 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 8.186285e-01 0.087 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.193344e-01 0.087 0 0
Binding and entry of HIV virion R-HSA-173107 8.211231e-01 0.086 0 0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 8.211231e-01 0.086 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 8.211231e-01 0.086 0 0
Regulation of the apoptosome activity R-HSA-9627069 8.211231e-01 0.086 0 0
Regulation of CDH11 function R-HSA-9762292 8.211231e-01 0.086 0 0
Formation of apoptosome R-HSA-111458 8.211231e-01 0.086 0 0
2-LTR circle formation R-HSA-164843 8.211231e-01 0.086 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.211231e-01 0.086 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 8.211231e-01 0.086 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 8.211231e-01 0.086 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 8.211231e-01 0.086 0 0
CASP4 inflammasome assembly R-HSA-9948001 8.211231e-01 0.086 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 8.211231e-01 0.086 0 0
Receptor Mediated Mitophagy R-HSA-8934903 8.211231e-01 0.086 0 0
Interleukin-27 signaling R-HSA-9020956 8.211231e-01 0.086 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 8.211231e-01 0.086 0 0
Maturation of spike protein R-HSA-9683686 8.211231e-01 0.086 0 0
MAPK3 (ERK1) activation R-HSA-110056 8.211231e-01 0.086 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.211231e-01 0.086 0 0
Serotonin receptors R-HSA-390666 8.211231e-01 0.086 0 0
Circadian clock R-HSA-9909396 8.221726e-01 0.085 0 0
Selenoamino acid metabolism R-HSA-2408522 8.255975e-01 0.083 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 8.258646e-01 0.083 0 0
Regulation of signaling by CBL R-HSA-912631 8.258646e-01 0.083 0 0
Other interleukin signaling R-HSA-449836 8.258646e-01 0.083 0 0
Crosslinking of collagen fibrils R-HSA-2243919 8.258646e-01 0.083 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.258646e-01 0.083 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.266527e-01 0.083 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.266527e-01 0.083 0 0
HIV elongation arrest and recovery R-HSA-167287 8.266527e-01 0.083 0 0
Pausing and recovery of HIV elongation R-HSA-167290 8.266527e-01 0.083 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.266527e-01 0.083 0 0
Translation initiation complex formation R-HSA-72649 8.273364e-01 0.082 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 8.273364e-01 0.082 0 0
Fanconi Anemia Pathway R-HSA-6783310 8.287127e-01 0.082 0 0
Cell junction organization R-HSA-446728 8.296057e-01 0.081 0 0
Degradation of DVL R-HSA-4641258 8.326420e-01 0.080 0 0
Ub-specific processing proteases R-HSA-5689880 8.363983e-01 0.078 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 8.382596e-01 0.077 0 0
HDACs deacetylate histones R-HSA-3214815 8.382596e-01 0.077 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 8.397390e-01 0.076 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 8.403782e-01 0.076 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 8.403782e-01 0.076 0 0
mRNA Capping R-HSA-72086 8.410062e-01 0.075 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.413058e-01 0.075 0 0
Downstream TCR signaling R-HSA-202424 8.415795e-01 0.075 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 8.426375e-01 0.074 0 0
Negative regulation of MET activity R-HSA-6807004 8.426375e-01 0.074 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 8.426375e-01 0.074 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 8.426375e-01 0.074 0 0
Acyl chain remodelling of PI R-HSA-1482922 8.426375e-01 0.074 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 8.426375e-01 0.074 0 0
Pregnenolone biosynthesis R-HSA-196108 8.426375e-01 0.074 0 0
Signal transduction by L1 R-HSA-445144 8.426375e-01 0.074 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 8.433128e-01 0.074 0 0
DAG1 core M3 glycosylations R-HSA-8932505 8.433128e-01 0.074 0 0
vRNA Synthesis R-HSA-192814 8.433128e-01 0.074 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.433128e-01 0.074 0 0
vRNP Assembly R-HSA-192905 8.433128e-01 0.074 0 0
Transport of RCbl within the body R-HSA-9758890 8.433128e-01 0.074 0 0
Chylomicron assembly R-HSA-8963888 8.433128e-01 0.074 0 0
LGI-ADAM interactions R-HSA-5682910 8.433128e-01 0.074 0 0
Telomere Maintenance R-HSA-157579 8.437675e-01 0.074 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.451215e-01 0.073 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.451215e-01 0.073 0 0
Signaling by NOTCH4 R-HSA-9013694 8.476277e-01 0.072 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 8.486179e-01 0.071 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.486179e-01 0.071 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.543189e-01 0.068 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 8.543189e-01 0.068 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.543189e-01 0.068 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 8.564308e-01 0.067 0 0
Pentose phosphate pathway R-HSA-71336 8.568066e-01 0.067 0 0
FGFR2 ligand binding and activation R-HSA-190241 8.579301e-01 0.067 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 8.579301e-01 0.067 0 0
Early Phase of HIV Life Cycle R-HSA-162594 8.579301e-01 0.067 0 0
Signalling to RAS R-HSA-167044 8.579301e-01 0.067 0 0
Lagging Strand Synthesis R-HSA-69186 8.579301e-01 0.067 0 0
Basigin interactions R-HSA-210991 8.579301e-01 0.067 0 0
Metal ion SLC transporters R-HSA-425410 8.617480e-01 0.065 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 8.627511e-01 0.064 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 8.627511e-01 0.064 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 8.627511e-01 0.064 0 0
Plasmalogen biosynthesis R-HSA-75896 8.627511e-01 0.064 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.627511e-01 0.064 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 8.628832e-01 0.064 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 8.666465e-01 0.062 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 8.677082e-01 0.062 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 8.677318e-01 0.062 0 0
Glycogen metabolism R-HSA-8982491 8.677318e-01 0.062 0 0
Interferon alpha/beta signaling R-HSA-909733 8.695323e-01 0.061 0 0
DNA Damage Bypass R-HSA-73893 8.715000e-01 0.060 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 8.718515e-01 0.060 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 8.718515e-01 0.060 0 0
Glutathione synthesis and recycling R-HSA-174403 8.718515e-01 0.060 0 0
G alpha (s) signalling events R-HSA-418555 8.737534e-01 0.059 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 8.779323e-01 0.057 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 8.779323e-01 0.057 0 0
DNA strand elongation R-HSA-69190 8.780448e-01 0.056 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 8.780448e-01 0.056 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.797788e-01 0.056 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.797788e-01 0.056 0 0
Interleukin-35 Signalling R-HSA-8984722 8.797788e-01 0.056 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.797788e-01 0.056 0 0
Proline catabolism R-HSA-70688 8.797788e-01 0.056 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 8.797788e-01 0.056 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.797788e-01 0.056 0 0
Polymerase switching R-HSA-69091 8.797788e-01 0.056 0 0
Leading Strand Synthesis R-HSA-69109 8.797788e-01 0.056 0 0
Pervasive developmental disorders R-HSA-9005895 8.797788e-01 0.056 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 8.797788e-01 0.056 0 0
Disorders of Nervous System Development R-HSA-9697154 8.797788e-01 0.056 0 0
Leishmania infection R-HSA-9658195 8.819073e-01 0.055 0 0
Parasitic Infection Pathways R-HSA-9824443 8.819073e-01 0.055 0 0
FGFR2 alternative splicing R-HSA-6803529 8.845065e-01 0.053 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.845065e-01 0.053 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 8.845065e-01 0.053 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 8.845065e-01 0.053 0 0
LDL clearance R-HSA-8964038 8.845065e-01 0.053 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.845065e-01 0.053 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.864633e-01 0.052 0 0
rRNA processing R-HSA-72312 8.868773e-01 0.052 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.874435e-01 0.052 0 0
Intra-Golgi traffic R-HSA-6811438 8.874435e-01 0.052 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 8.885687e-01 0.051 0 0
Potential therapeutics for SARS R-HSA-9679191 8.932252e-01 0.049 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 8.944691e-01 0.048 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 8.946949e-01 0.048 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 8.946949e-01 0.048 0 0
Mtb iron assimilation by chelation R-HSA-1222449 8.946949e-01 0.048 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 8.946949e-01 0.048 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.946949e-01 0.048 0 0
Diseases of nucleotide metabolism R-HSA-9735804 8.946949e-01 0.048 0 0
Processing of SMDT1 R-HSA-8949664 8.946949e-01 0.048 0 0
rRNA modification in the mitochondrion R-HSA-6793080 8.946949e-01 0.048 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.946949e-01 0.048 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 8.959949e-01 0.048 0 0
Formation of the ureteric bud R-HSA-9830674 8.959949e-01 0.048 0 0
Carnitine shuttle R-HSA-200425 8.959949e-01 0.048 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 8.965849e-01 0.047 0 0
SARS-CoV Infections R-HSA-9679506 8.966205e-01 0.047 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 8.973218e-01 0.047 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.982721e-01 0.047 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 8.984531e-01 0.047 0 0
Activation of HOX genes during differentiation R-HSA-5619507 8.984531e-01 0.047 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.998987e-01 0.046 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.027987e-01 0.044 0 0
Defective pyroptosis R-HSA-9710421 9.045384e-01 0.044 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 9.048683e-01 0.043 0 0
Nucleotide biosynthesis R-HSA-8956320 9.048683e-01 0.043 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.054356e-01 0.043 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.064114e-01 0.043 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.064114e-01 0.043 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.064114e-01 0.043 0 0
eNOS activation R-HSA-203615 9.072074e-01 0.042 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.072074e-01 0.042 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.072074e-01 0.042 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.072074e-01 0.042 0 0
Mitophagy R-HSA-5205647 9.072074e-01 0.042 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.072074e-01 0.042 0 0
Retrograde neurotrophin signalling R-HSA-177504 9.077611e-01 0.042 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 9.077611e-01 0.042 0 0
Hydrolysis of LPC R-HSA-1483115 9.077611e-01 0.042 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 9.077611e-01 0.042 0 0
Vitamin B2 (riboflavin) metabolism R-HSA-196843 9.077611e-01 0.042 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 9.077611e-01 0.042 0 0
Non-canonical inflammasome activation R-HSA-9686114 9.077611e-01 0.042 0 0
Prolactin receptor signaling R-HSA-1170546 9.077611e-01 0.042 0 0
Malate-aspartate shuttle R-HSA-9856872 9.077611e-01 0.042 0 0
HDL assembly R-HSA-8963896 9.077611e-01 0.042 0 0
Zinc transporters R-HSA-435354 9.077611e-01 0.042 0 0
P2Y receptors R-HSA-417957 9.077611e-01 0.042 0 0
Developmental Cell Lineages R-HSA-9734767 9.087759e-01 0.042 0 0
Switching of origins to a post-replicative state R-HSA-69052 9.096386e-01 0.041 0 0
HCMV Early Events R-HSA-9609690 9.096922e-01 0.041 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 9.096922e-01 0.041 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.121911e-01 0.040 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 9.158451e-01 0.038 0 0
Tight junction interactions R-HSA-420029 9.158451e-01 0.038 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.158451e-01 0.038 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.158451e-01 0.038 0 0
G protein gated Potassium channels R-HSA-1296059 9.158451e-01 0.038 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 9.158451e-01 0.038 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 9.158451e-01 0.038 0 0
Immune System R-HSA-168256 9.170447e-01 0.038 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 9.176052e-01 0.037 0 0
Adipogenesis R-HSA-9843745 9.185280e-01 0.037 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 9.192067e-01 0.037 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.192067e-01 0.037 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.192067e-01 0.037 0 0
Telomere C-strand synthesis initiation R-HSA-174430 9.192067e-01 0.037 0 0
Protein lipoylation R-HSA-9857492 9.192067e-01 0.037 0 0
p38MAPK events R-HSA-171007 9.192067e-01 0.037 0 0
DNA Damage Reversal R-HSA-73942 9.192067e-01 0.037 0 0
Protein repair R-HSA-5676934 9.192067e-01 0.037 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 9.192067e-01 0.037 0 0
Biotin transport and metabolism R-HSA-196780 9.192067e-01 0.037 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 9.192067e-01 0.037 0 0
Somitogenesis R-HSA-9824272 9.192922e-01 0.037 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.192922e-01 0.037 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.192922e-01 0.037 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.229746e-01 0.035 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.229746e-01 0.035 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.229746e-01 0.035 0 0
MET activates PTK2 signaling R-HSA-8874081 9.243793e-01 0.034 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.243793e-01 0.034 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.251208e-01 0.034 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.258742e-01 0.033 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.258742e-01 0.033 0 0
Assembly of the pre-replicative complex R-HSA-68867 9.264145e-01 0.033 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.264145e-01 0.033 0 0
Adaptive Immune System R-HSA-1280218 9.291848e-01 0.032 0 0
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-2142816 9.292326e-01 0.032 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 9.292326e-01 0.032 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 9.292326e-01 0.032 0 0
Killing mechanisms R-HSA-9664420 9.292326e-01 0.032 0 0
Synthesis of wybutosine at G37 of tRNA(Phe) R-HSA-6782861 9.292326e-01 0.032 0 0
Regulation of endogenous retroelements R-HSA-9842860 9.293293e-01 0.032 0 0
Adherens junctions interactions R-HSA-418990 9.294913e-01 0.032 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.299019e-01 0.032 0 0
Cleavage of the damaged purine R-HSA-110331 9.299019e-01 0.032 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.299019e-01 0.032 0 0
NCAM1 interactions R-HSA-419037 9.299019e-01 0.032 0 0
GPCR downstream signalling R-HSA-388396 9.318476e-01 0.031 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.319686e-01 0.031 0 0
Packaging Of Telomere Ends R-HSA-171306 9.320921e-01 0.031 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.320921e-01 0.031 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.320921e-01 0.031 0 0
Insulin processing R-HSA-264876 9.320921e-01 0.031 0 0
Depurination R-HSA-73927 9.362518e-01 0.029 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.376057e-01 0.028 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.380149e-01 0.028 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 9.380149e-01 0.028 0 0
Glycine degradation R-HSA-6783984 9.380149e-01 0.028 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 9.380149e-01 0.028 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 9.380149e-01 0.028 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.380149e-01 0.028 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.390558e-01 0.027 0 0
Pyrimidine salvage R-HSA-73614 9.390558e-01 0.027 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.395743e-01 0.027 0 0
Triglyceride metabolism R-HSA-8979227 9.407291e-01 0.027 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.407291e-01 0.027 0 0
RAS processing R-HSA-9648002 9.420663e-01 0.026 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.432293e-01 0.025 0 0
DNA methylation R-HSA-5334118 9.453375e-01 0.024 0 0
Termination of translesion DNA synthesis R-HSA-5656169 9.453375e-01 0.024 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.453375e-01 0.024 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.453375e-01 0.024 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.453528e-01 0.024 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.473855e-01 0.023 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 9.473855e-01 0.023 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 9.473855e-01 0.023 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 9.473855e-01 0.023 0 0
Co-inhibition by PD-1 R-HSA-389948 9.496568e-01 0.022 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.509992e-01 0.022 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.509992e-01 0.022 0 0
The phototransduction cascade R-HSA-2514856 9.520596e-01 0.021 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.522471e-01 0.021 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.522471e-01 0.021 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.522471e-01 0.021 0 0
Maturation of spike protein R-HSA-9694548 9.522471e-01 0.021 0 0
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142670 9.524462e-01 0.021 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.524462e-01 0.021 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.524462e-01 0.021 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.524462e-01 0.021 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.524462e-01 0.021 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.556759e-01 0.020 0 0
Orc1 removal from chromatin R-HSA-68949 9.561472e-01 0.019 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.561472e-01 0.019 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.566863e-01 0.019 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.566863e-01 0.019 0 0
Translation of Structural Proteins R-HSA-9683701 9.566863e-01 0.019 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 9.583487e-01 0.018 0 0
Translesion Synthesis by POLH R-HSA-110320 9.583487e-01 0.018 0 0
Pyrimidine biosynthesis R-HSA-500753 9.583487e-01 0.018 0 0
HDL remodeling R-HSA-8964058 9.583487e-01 0.018 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.583487e-01 0.018 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.599108e-01 0.018 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.633733e-01 0.016 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 9.635189e-01 0.016 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 9.635189e-01 0.016 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.635189e-01 0.016 0 0
Signaling by NODAL R-HSA-1181150 9.635189e-01 0.016 0 0
Glycogen synthesis R-HSA-3322077 9.635189e-01 0.016 0 0
Cellular response to hypoxia R-HSA-1234174 9.639267e-01 0.016 0 0
DNA Replication R-HSA-69306 9.642072e-01 0.016 0 0
Mitochondrial protein degradation R-HSA-9837999 9.644307e-01 0.016 0 0
Cell-cell junction organization R-HSA-421270 9.649252e-01 0.016 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.671939e-01 0.014 0 0
Surfactant metabolism R-HSA-5683826 9.677917e-01 0.014 0 0
Translation of Structural Proteins R-HSA-9694635 9.680098e-01 0.014 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.680475e-01 0.014 0 0
G-protein activation R-HSA-202040 9.680475e-01 0.014 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.680475e-01 0.014 0 0
Heme degradation R-HSA-189483 9.685203e-01 0.014 0 0
PCP/CE pathway R-HSA-4086400 9.704907e-01 0.013 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.708527e-01 0.013 0 0
G alpha (q) signalling events R-HSA-416476 9.710856e-01 0.013 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.718501e-01 0.012 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.718501e-01 0.012 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.720142e-01 0.012 0 0
Androgen biosynthesis R-HSA-193048 9.720142e-01 0.012 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.720142e-01 0.012 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.720142e-01 0.012 0 0
Serine metabolism R-HSA-977347 9.720142e-01 0.012 0 0
Glucocorticoid biosynthesis R-HSA-194002 9.720142e-01 0.012 0 0
Synthesis of PA R-HSA-1483166 9.721630e-01 0.012 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.727934e-01 0.012 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.746241e-01 0.011 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.748385e-01 0.011 0 0
Synthesis of DNA R-HSA-69239 9.751817e-01 0.011 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.754887e-01 0.011 0 0
Fructose metabolism R-HSA-5652084 9.754887e-01 0.011 0 0
Ethanol oxidation R-HSA-71384 9.754887e-01 0.011 0 0
Cellular hexose transport R-HSA-189200 9.754887e-01 0.011 0 0
Base Excision Repair R-HSA-73884 9.759184e-01 0.011 0 0
HCMV Infection R-HSA-9609646 9.760874e-01 0.011 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 9.761671e-01 0.010 0 0
Synthesis of PC R-HSA-1483191 9.761671e-01 0.010 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 9.768797e-01 0.010 0 0
PRC2 methylates histones and DNA R-HSA-212300 9.775191e-01 0.010 0 0
Glycosphingolipid transport R-HSA-9845576 9.775191e-01 0.010 0 0
tRNA processing R-HSA-72306 9.783962e-01 0.009 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.785320e-01 0.009 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.785320e-01 0.009 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.799221e-01 0.009 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.799221e-01 0.009 0 0
Degradation of AXIN R-HSA-4641257 9.799221e-01 0.009 0 0
Degradation of CDH1 R-HSA-9766229 9.805513e-01 0.009 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.809994e-01 0.008 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.811976e-01 0.008 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.811976e-01 0.008 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 9.811976e-01 0.008 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.811976e-01 0.008 0 0
Elastic fibre formation R-HSA-1566948 9.820751e-01 0.008 0 0
PPARA activates gene expression R-HSA-1989781 9.821316e-01 0.008 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.826799e-01 0.008 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.826993e-01 0.008 0 0
Signaling by GPCR R-HSA-372790 9.830302e-01 0.007 0 0
Hyaluronan degradation R-HSA-2160916 9.835323e-01 0.007 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.835323e-01 0.007 0 0
Laminin interactions R-HSA-3000157 9.835323e-01 0.007 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.835323e-01 0.007 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.840032e-01 0.007 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 9.840032e-01 0.007 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.840032e-01 0.007 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.840032e-01 0.007 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.841588e-01 0.007 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.842715e-01 0.007 0 0
Protein ubiquitination R-HSA-8852135 9.849149e-01 0.007 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.849149e-01 0.007 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.855773e-01 0.006 0 0
Urea cycle R-HSA-70635 9.855773e-01 0.006 0 0
Abacavir ADME R-HSA-2161522 9.855773e-01 0.006 0 0
Sphingolipid catabolism R-HSA-9845614 9.855773e-01 0.006 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.855773e-01 0.006 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.857128e-01 0.006 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.857290e-01 0.006 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.857290e-01 0.006 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.872730e-01 0.006 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.873684e-01 0.006 0 0
Synthesis of PE R-HSA-1483213 9.873684e-01 0.006 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.883933e-01 0.005 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.886537e-01 0.005 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.886537e-01 0.005 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.887885e-01 0.005 0 0
Prednisone ADME R-HSA-9757110 9.889372e-01 0.005 0 0
Insulin receptor recycling R-HSA-77387 9.889372e-01 0.005 0 0
ER-Phagosome pathway R-HSA-1236974 9.892187e-01 0.005 0 0
Protein localization R-HSA-9609507 9.892894e-01 0.005 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.894692e-01 0.005 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.895368e-01 0.005 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.898879e-01 0.004 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.898879e-01 0.004 0 0
Depyrimidination R-HSA-73928 9.898879e-01 0.004 0 0
Thyroxine biosynthesis R-HSA-209968 9.903112e-01 0.004 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.903112e-01 0.004 0 0
Glucagon-type ligand receptors R-HSA-420092 9.903112e-01 0.004 0 0
ABC-family proteins mediated transport R-HSA-382556 9.908894e-01 0.004 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.909906e-01 0.004 0 0
Amyloid fiber formation R-HSA-977225 9.912607e-01 0.004 0 0
Regulation of CDH1 Function R-HSA-9764561 9.915271e-01 0.004 0 0
HCMV Late Events R-HSA-9610379 9.918576e-01 0.004 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.919520e-01 0.004 0 0
COPII-mediated vesicle transport R-HSA-204005 9.919520e-01 0.004 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.924012e-01 0.003 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.925687e-01 0.003 0 0
Cargo concentration in the ER R-HSA-5694530 9.925687e-01 0.003 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.925687e-01 0.003 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.925687e-01 0.003 0 0
Metabolism of cofactors R-HSA-8978934 9.927070e-01 0.003 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.927391e-01 0.003 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.928547e-01 0.003 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.928547e-01 0.003 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.931279e-01 0.003 0 0
Parasite infection R-HSA-9664407 9.931279e-01 0.003 0 0
Leishmania phagocytosis R-HSA-9664417 9.931279e-01 0.003 0 0
Peroxisomal protein import R-HSA-9033241 9.931436e-01 0.003 0 0
DAG1 glycosylations R-HSA-8931838 9.934918e-01 0.003 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.934918e-01 0.003 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 9.938356e-01 0.003 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.938356e-01 0.003 0 0
RSV-host interactions R-HSA-9833110 9.940299e-01 0.003 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.943003e-01 0.002 0 0
Collagen degradation R-HSA-1442490 9.944597e-01 0.002 0 0
Nucleotide salvage R-HSA-8956321 9.944597e-01 0.002 0 0
Gluconeogenesis R-HSA-70263 9.949639e-01 0.002 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.949747e-01 0.002 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.950085e-01 0.002 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.950113e-01 0.002 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.955205e-01 0.002 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.955205e-01 0.002 0 0
UCH proteinases R-HSA-5689603 9.955687e-01 0.002 0 0
Signal amplification R-HSA-392518 9.956286e-01 0.002 0 0
Hyaluronan metabolism R-HSA-2142845 9.956286e-01 0.002 0 0
RA biosynthesis pathway R-HSA-5365859 9.956286e-01 0.002 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.956286e-01 0.002 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.956286e-01 0.002 0 0
Viral Infection Pathways R-HSA-9824446 9.957938e-01 0.002 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.959415e-01 0.002 0 0
SLC transporter disorders R-HSA-5619102 9.959898e-01 0.002 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.961718e-01 0.002 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.961718e-01 0.002 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.961718e-01 0.002 0 0
Regulation of Apoptosis R-HSA-169911 9.961718e-01 0.002 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.961718e-01 0.002 0 0
ABC transporter disorders R-HSA-5619084 9.963784e-01 0.002 0 0
Neurotransmitter release cycle R-HSA-112310 9.965925e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.970998e-01 0.001 0 0
Purine salvage R-HSA-74217 9.974289e-01 0.001 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.974414e-01 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 9.976301e-01 0.001 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.977182e-01 0.001 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.977485e-01 0.001 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.977485e-01 0.001 0 0
Collagen formation R-HSA-1474290 9.979003e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.979102e-01 0.001 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.980283e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.981275e-01 0.001 0 0
Retinoid metabolism and transport R-HSA-975634 9.981275e-01 0.001 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.982734e-01 0.001 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.984052e-01 0.001 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.984880e-01 0.001 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.986288e-01 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.986552e-01 0.001 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.986760e-01 0.001 0 0
tRNA Aminoacylation R-HSA-379724 9.987833e-01 0.001 0 0
Glutathione conjugation R-HSA-156590 9.987833e-01 0.001 0 0
Defensins R-HSA-1461973 9.988406e-01 0.001 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.988406e-01 0.001 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.988406e-01 0.001 0 0
Endogenous sterols R-HSA-211976 9.989205e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.989424e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.989424e-01 0.000 0 0
Proteasome assembly R-HSA-9907900 9.989847e-01 0.000 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.989847e-01 0.000 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.991109e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.991380e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.991508e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.992031e-01 0.000 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.992215e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.992292e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.993818e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.993841e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.994755e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.994755e-01 0.000 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.994773e-01 0.000 0 0
Azathioprine ADME R-HSA-9748787 9.995423e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.995423e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.995898e-01 0.000 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.995992e-01 0.000 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.996491e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.996768e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.996768e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.996810e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.996873e-01 0.000 0 0
Neddylation R-HSA-8951664 9.997107e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.997138e-01 0.000 0 0
Paracetamol ADME R-HSA-9753281 9.997644e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.997937e-01 0.000 0 0
Digestion R-HSA-8935690 9.997937e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.997952e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.998615e-01 0.000 0 0
Integrin cell surface interactions R-HSA-216083 9.998623e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.998623e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.998788e-01 0.000 0 0
Translation R-HSA-72766 9.998936e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999005e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999063e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999186e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999210e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999210e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.999288e-01 0.000 0 0
Glycosphingolipid biosynthesis R-HSA-9840309 9.999288e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.999288e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999370e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999374e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999376e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.999581e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.999635e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999650e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999679e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999686e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999722e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999754e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999785e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999785e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999798e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.999835e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999846e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999878e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999889e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.999892e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999929e-01 0.000 0 0
Disease R-HSA-1643685 9.999941e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999952e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999953e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999957e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999966e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999971e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999974e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999975e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999984e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999987e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999991e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999993e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999995e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999995e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999997e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999997e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999998e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999999e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999999e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999999e-01 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Post-translational protein modification R-HSA-597592 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 0 0
Cell Cycle, Mitotic R-HSA-69278 1.110223e-16 15.955 0 0
M Phase R-HSA-68886 4.440892e-15 14.353 0 0
Cellular response to heat stress R-HSA-3371556 1.312728e-12 11.882 0 0
HSF1-dependent transactivation R-HSA-3371571 1.290978e-11 10.889 0 0
Cellular responses to stress R-HSA-2262752 1.254719e-11 10.901 0 0
Cellular responses to stimuli R-HSA-8953897 4.971801e-11 10.303 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 8.747558e-11 10.058 0 0
Separation of Sister Chromatids R-HSA-2467813 1.213967e-09 8.916 0 0
Attenuation phase R-HSA-3371568 1.270325e-09 8.896 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.445310e-09 8.840 0 0
Mitotic Anaphase R-HSA-68882 1.984621e-09 8.702 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.313946e-09 8.636 0 0
Mitotic Prometaphase R-HSA-68877 4.329259e-09 8.364 0 0
Metabolism of RNA R-HSA-8953854 7.125672e-09 8.147 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.567634e-08 7.590 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.033003e-07 6.986 0 0
G2/M Transition R-HSA-69275 1.282129e-07 6.892 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.707918e-07 6.768 0 0
Recycling pathway of L1 R-HSA-437239 3.864430e-07 6.413 0 0
Axon guidance R-HSA-422475 4.080176e-07 6.389 0 0
Interleukin-12 signaling R-HSA-9020591 4.202612e-07 6.376 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 4.415483e-07 6.355 0 0
Aggrephagy R-HSA-9646399 5.036077e-07 6.298 0 0
HSF1 activation R-HSA-3371511 5.552960e-07 6.255 0 0
Nervous system development R-HSA-9675108 7.878989e-07 6.104 0 0
Apoptotic execution phase R-HSA-75153 1.089410e-06 5.963 0 0
Cell Cycle Checkpoints R-HSA-69620 1.119389e-06 5.951 0 0
Interleukin-12 family signaling R-HSA-447115 1.811380e-06 5.742 0 0
Mitotic Prophase R-HSA-68875 4.091178e-06 5.388 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 5.143154e-06 5.289 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.455653e-06 5.263 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 8.548792e-06 5.068 0 0
HIV Life Cycle R-HSA-162587 8.543338e-06 5.068 0 0
PKR-mediated signaling R-HSA-9833482 8.806472e-06 5.055 0 0
ISG15 antiviral mechanism R-HSA-1169408 9.453604e-06 5.024 0 0
Kinesins R-HSA-983189 1.090482e-05 4.962 0 0
Late endosomal microautophagy R-HSA-9615710 1.182116e-05 4.927 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.334541e-05 4.875 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.334541e-05 4.875 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.320074e-05 4.879 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.311671e-05 4.882 0 0
Influenza Infection R-HSA-168255 1.450933e-05 4.838 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.681476e-05 4.774 0 0
Selective autophagy R-HSA-9663891 1.681476e-05 4.774 0 0
Autophagy R-HSA-9612973 1.663233e-05 4.779 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.731892e-05 4.761 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.828459e-05 4.738 0 0
Interferon Signaling R-HSA-913531 2.078986e-05 4.682 0 0
Signaling by ROBO receptors R-HSA-376176 2.474749e-05 4.606 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.521281e-05 4.598 0 0
Translation initiation complex formation R-HSA-72649 2.789038e-05 4.555 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.005460e-05 4.522 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.121168e-05 4.506 0 0
Apoptosis R-HSA-109581 3.468521e-05 4.460 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 4.034270e-05 4.394 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 4.274021e-05 4.369 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.296849e-05 4.367 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 4.213561e-05 4.375 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.550633e-05 4.342 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 4.701363e-05 4.328 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.937610e-05 4.306 0 0
Macroautophagy R-HSA-1632852 5.102629e-05 4.292 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 5.579048e-05 4.253 0 0
Mitotic Spindle Checkpoint R-HSA-69618 6.418666e-05 4.193 0 0
Chaperone Mediated Autophagy R-HSA-9613829 6.443072e-05 4.191 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 6.492722e-05 4.188 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 6.541686e-05 4.184 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 6.553467e-05 4.184 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 7.253382e-05 4.139 0 0
Formation of a pool of free 40S subunits R-HSA-72689 7.338426e-05 4.134 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 8.470826e-05 4.072 0 0
Gap junction trafficking R-HSA-190828 9.185862e-05 4.037 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.510797e-05 4.022 0 0
Post NMDA receptor activation events R-HSA-438064 9.510797e-05 4.022 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.178563e-04 3.929 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.125621e-04 3.949 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.179047e-04 3.928 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.451018e-04 3.838 0 0
Signaling by RAS mutants R-HSA-6802949 1.427362e-04 3.845 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.427362e-04 3.845 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.427362e-04 3.845 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.427362e-04 3.845 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.480548e-04 3.830 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.386760e-04 3.858 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.408177e-04 3.851 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.526491e-04 3.816 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.534207e-04 3.814 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.605019e-04 3.795 0 0
L1CAM interactions R-HSA-373760 1.666193e-04 3.778 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.886977e-04 3.724 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.986007e-04 3.702 0 0
Signaling by ALK in cancer R-HSA-9700206 1.986007e-04 3.702 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 2.032501e-04 3.692 0 0
Protein folding R-HSA-391251 2.348298e-04 3.629 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.375110e-04 3.624 0 0
Programmed Cell Death R-HSA-5357801 2.453080e-04 3.610 0 0
Gap junction trafficking and regulation R-HSA-157858 2.648797e-04 3.577 0 0
HIV Infection R-HSA-162906 2.792741e-04 3.554 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.968583e-04 3.527 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.837397e-04 3.547 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.968583e-04 3.527 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.980735e-04 3.526 0 0
Spry regulation of FGF signaling R-HSA-1295596 3.113746e-04 3.507 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 4.136833e-04 3.383 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 4.170309e-04 3.380 0 0
Amplification of signal from the kinetochores R-HSA-141424 4.170309e-04 3.380 0 0
Regulation of CDH1 Function R-HSA-9764561 4.233593e-04 3.373 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 4.418199e-04 3.355 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 4.784019e-04 3.320 0 0
Homology Directed Repair R-HSA-5693538 4.612308e-04 3.336 0 0
Signaling by RAF1 mutants R-HSA-9656223 4.546074e-04 3.342 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 4.555291e-04 3.341 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 4.866517e-04 3.313 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 4.909383e-04 3.309 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 4.909383e-04 3.309 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 5.485779e-04 3.261 0 0
Estrogen-dependent gene expression R-HSA-9018519 5.515468e-04 3.258 0 0
Metabolism of non-coding RNA R-HSA-194441 5.977152e-04 3.224 0 0
snRNP Assembly R-HSA-191859 5.977152e-04 3.224 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 5.562553e-04 3.255 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 5.863839e-04 3.232 0 0
Cytokine Signaling in Immune system R-HSA-1280215 5.881020e-04 3.231 0 0
Striated Muscle Contraction R-HSA-390522 6.182976e-04 3.209 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 6.182976e-04 3.209 0 0
Signal Transduction R-HSA-162582 6.699456e-04 3.174 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 6.893154e-04 3.162 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 7.372589e-04 3.132 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 7.372589e-04 3.132 0 0
AURKA Activation by TPX2 R-HSA-8854518 7.285970e-04 3.138 0 0
Ribosome-associated quality control R-HSA-9948299 6.808991e-04 3.167 0 0
mRNA Splicing R-HSA-72172 7.556303e-04 3.122 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 7.724556e-04 3.112 0 0
Gap junction assembly R-HSA-190861 7.724556e-04 3.112 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 7.944226e-04 3.100 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 8.064254e-04 3.093 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 8.064254e-04 3.093 0 0
SARS-CoV-1-host interactions R-HSA-9692914 8.441498e-04 3.074 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 8.581283e-04 3.066 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 8.581283e-04 3.066 0 0
Regulation of PTEN localization R-HSA-8948747 9.396487e-04 3.027 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 9.396487e-04 3.027 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 8.953878e-04 3.048 0 0
Membrane Trafficking R-HSA-199991 9.596955e-04 3.018 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 9.906498e-04 3.004 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.000867e-03 3.000 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.000867e-03 3.000 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.033771e-03 2.986 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.039903e-03 2.983 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.137198e-03 2.944 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.137198e-03 2.944 0 0
Centrosome maturation R-HSA-380287 1.143025e-03 2.942 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 1.165660e-03 2.933 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.213956e-03 2.916 0 0
p75NTR signals via NF-kB R-HSA-193639 1.389146e-03 2.857 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.326916e-03 2.877 0 0
Peptide chain elongation R-HSA-156902 1.425018e-03 2.846 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.519128e-03 2.818 0 0
NF-kB is activated and signals survival R-HSA-209560 1.535652e-03 2.814 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.548528e-03 2.810 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.579889e-03 2.801 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.582633e-03 2.801 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.903352e-03 2.720 0 0
Eukaryotic Translation Termination R-HSA-72764 1.963097e-03 2.707 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 2.058320e-03 2.686 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.062107e-03 2.686 0 0
Nephrin family interactions R-HSA-373753 2.073965e-03 2.683 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.078888e-03 2.682 0 0
Cilium Assembly R-HSA-5617833 2.196431e-03 2.658 0 0
rRNA processing R-HSA-72312 2.212931e-03 2.655 0 0
Nuclear import of Rev protein R-HSA-180746 2.322216e-03 2.634 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 2.337181e-03 2.631 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.589346e-03 2.587 0 0
Chromatin organization R-HSA-4839726 2.628752e-03 2.580 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.645438e-03 2.578 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.645438e-03 2.578 0 0
G2/M Checkpoints R-HSA-69481 2.681610e-03 2.572 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.785489e-03 2.555 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.813374e-03 2.551 0 0
Cellular Senescence R-HSA-2559583 3.049137e-03 2.516 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.138737e-03 2.503 0 0
ESR-mediated signaling R-HSA-8939211 3.139445e-03 2.503 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.301682e-03 2.481 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 3.449268e-03 2.462 0 0
Josephin domain DUBs R-HSA-5689877 3.449268e-03 2.462 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 3.449268e-03 2.462 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 3.705506e-03 2.431 0 0
Hedgehog 'off' state R-HSA-5610787 3.422896e-03 2.466 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 3.449268e-03 2.462 0 0
Host Interactions of HIV factors R-HSA-162909 3.492942e-03 2.457 0 0
Selenocysteine synthesis R-HSA-2408557 3.804084e-03 2.420 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 3.497332e-03 2.456 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.861055e-03 2.413 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 4.048338e-03 2.393 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 4.048338e-03 2.393 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 4.165903e-03 2.380 0 0
Cell-Cell communication R-HSA-1500931 4.207089e-03 2.376 0 0
Signaling by ERBB2 R-HSA-1227986 4.220030e-03 2.375 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.285496e-03 2.368 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 4.313566e-03 2.365 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.677166e-03 2.330 0 0
Signaling by FGFR2 R-HSA-5654738 4.828723e-03 2.316 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 4.913536e-03 2.309 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.937349e-03 2.307 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 5.312903e-03 2.275 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.667347e-03 2.247 0 0
Signaling by EGFR R-HSA-177929 5.667347e-03 2.247 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 6.071656e-03 2.217 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 6.178021e-03 2.209 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 6.789400e-03 2.168 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 6.720209e-03 2.173 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 6.789400e-03 2.168 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 6.789400e-03 2.168 0 0
Negative regulation of MET activity R-HSA-6807004 7.104771e-03 2.148 0 0
S Phase R-HSA-69242 6.476429e-03 2.189 0 0
Chromatin modifying enzymes R-HSA-3247509 6.776052e-03 2.169 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 6.789400e-03 2.168 0 0
Negative regulation of FLT3 R-HSA-9706369 7.241913e-03 2.140 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 7.315217e-03 2.136 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 7.623133e-03 2.118 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 7.807156e-03 2.108 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 7.807156e-03 2.108 0 0
Formation of annular gap junctions R-HSA-196025 7.833416e-03 2.106 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.833416e-03 2.106 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.833416e-03 2.106 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 8.398855e-03 2.076 0 0
Budding and maturation of HIV virion R-HSA-162588 8.746861e-03 2.058 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 9.004322e-03 2.046 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 9.004322e-03 2.046 0 0
Viral mRNA Translation R-HSA-192823 9.016328e-03 2.045 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.031219e-03 2.044 0 0
MAP2K and MAPK activation R-HSA-5674135 9.078307e-03 2.042 0 0
Negative regulation of MAPK pathway R-HSA-5675221 9.078307e-03 2.042 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 9.136128e-03 2.039 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 9.136128e-03 2.039 0 0
p75NTR recruits signalling complexes R-HSA-209543 9.136128e-03 2.039 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 9.294509e-03 2.032 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 9.294509e-03 2.032 0 0
Regulation of TP53 Activity R-HSA-5633007 9.347916e-03 2.029 1 0
Gap junction degradation R-HSA-190873 1.108340e-02 1.955 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 1.108340e-02 1.955 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.091320e-02 1.962 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.056697e-02 1.976 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.056697e-02 1.976 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 9.991955e-03 2.000 0 0
Death Receptor Signaling R-HSA-73887 1.022843e-02 1.990 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 9.757470e-03 2.011 0 0
Assembly Of The HIV Virion R-HSA-175474 1.091320e-02 1.962 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 9.560406e-03 2.020 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.126400e-02 1.948 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.175117e-02 1.930 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.183332e-02 1.927 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.185733e-02 1.926 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.201148e-02 1.920 0 0
Signaling by FGFR4 R-HSA-5654743 1.209888e-02 1.917 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.224397e-02 1.912 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.224397e-02 1.912 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.227509e-02 1.911 0 0
Maturation of protein E R-HSA-9683683 1.227509e-02 1.911 0 0
Maturation of protein E R-HSA-9694493 1.227509e-02 1.911 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 1.330227e-02 1.876 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.409209e-02 1.851 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 1.409209e-02 1.851 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.416179e-02 1.849 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.434453e-02 1.843 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.462662e-02 1.835 0 0
Cell junction organization R-HSA-446728 1.481429e-02 1.829 0 0
Deubiquitination R-HSA-5688426 1.485442e-02 1.828 0 0
Pexophagy R-HSA-9664873 1.514914e-02 1.820 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.514914e-02 1.820 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.542537e-02 1.812 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.547045e-02 1.810 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.821965e-02 1.739 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.665443e-02 1.778 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.665443e-02 1.778 0 0
Dual Incision in GG-NER R-HSA-5696400 1.670306e-02 1.777 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.800422e-02 1.745 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.574244e-02 1.803 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.583656e-02 1.800 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.807560e-02 1.743 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.798211e-02 1.745 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.877913e-02 1.726 0 0
DNA Repair R-HSA-73894 1.788013e-02 1.748 0 0
Signaling by FGFR3 R-HSA-5654741 1.583656e-02 1.800 0 0
G alpha (12/13) signalling events R-HSA-416482 1.617433e-02 1.791 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.806919e-02 1.743 0 0
Adherens junctions interactions R-HSA-418990 1.578471e-02 1.802 0 0
MHC class II antigen presentation R-HSA-2132295 1.900221e-02 1.721 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.919123e-02 1.717 0 0
Smooth Muscle Contraction R-HSA-445355 1.925200e-02 1.716 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.930978e-02 1.714 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.956412e-02 1.709 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.956412e-02 1.709 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.956412e-02 1.709 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 1.956412e-02 1.709 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.956412e-02 1.709 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.956412e-02 1.709 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 2.010683e-02 1.697 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 2.038691e-02 1.691 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.073621e-02 1.683 0 0
DNA Double Strand Break Response R-HSA-5693606 2.085770e-02 1.681 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.158061e-02 1.666 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 2.159780e-02 1.666 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.184469e-02 1.661 0 0
FLT3 signaling in disease R-HSA-9682385 2.226234e-02 1.652 0 0
EGFR downregulation R-HSA-182971 2.277437e-02 1.643 0 0
Intraflagellar transport R-HSA-5620924 2.299627e-02 1.638 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 2.346364e-02 1.630 0 0
Signaling by VEGF R-HSA-194138 2.368491e-02 1.626 0 0
Ub-specific processing proteases R-HSA-5689880 2.371336e-02 1.625 0 0
Prolonged ERK activation events R-HSA-169893 2.433869e-02 1.614 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 2.433869e-02 1.614 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.531824e-02 1.597 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.531824e-02 1.597 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.602087e-02 1.585 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.602087e-02 1.585 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 2.763596e-02 1.559 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 2.785368e-02 1.555 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 3.035373e-02 1.518 0 0
DNA Damage Bypass R-HSA-73893 2.584366e-02 1.588 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.495802e-02 1.603 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 2.983467e-02 1.525 0 0
Regulation of mitotic cell cycle R-HSA-453276 3.083196e-02 1.511 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 3.083196e-02 1.511 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.664392e-02 1.574 1 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 3.035373e-02 1.518 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.035373e-02 1.518 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.017311e-02 1.520 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 2.495802e-02 1.603 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.691914e-02 1.570 0 0
Cell-cell junction organization R-HSA-421270 2.687224e-02 1.571 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.637222e-02 1.579 0 0
Cellular response to chemical stress R-HSA-9711123 2.870912e-02 1.542 0 0
tRNA processing in the nucleus R-HSA-6784531 2.495802e-02 1.603 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.672547e-02 1.573 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 3.121761e-02 1.506 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.121761e-02 1.506 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 3.229610e-02 1.491 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 3.294273e-02 1.482 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 3.294273e-02 1.482 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 3.294273e-02 1.482 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 3.294273e-02 1.482 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 3.294273e-02 1.482 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 3.294273e-02 1.482 0 0
VLDLR internalisation and degradation R-HSA-8866427 3.294273e-02 1.482 0 0
IRAK1 recruits IKK complex R-HSA-937039 3.294273e-02 1.482 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 3.294273e-02 1.482 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.294876e-02 1.482 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.379579e-02 1.471 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.409046e-02 1.467 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.409046e-02 1.467 0 0
Modulation by Mtb of host immune system R-HSA-9637628 3.409046e-02 1.467 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.473606e-02 1.459 0 0
Resolution of D-Loop Structures R-HSA-5693537 3.473606e-02 1.459 0 0
Fanconi Anemia Pathway R-HSA-6783310 3.474549e-02 1.459 0 0
Signaling by FGFR R-HSA-190236 3.524084e-02 1.453 0 0
Cellular response to starvation R-HSA-9711097 3.537086e-02 1.451 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 3.592181e-02 1.445 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.608620e-02 1.443 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.608620e-02 1.443 0 0
Signaling by Hippo R-HSA-2028269 3.608620e-02 1.443 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.638087e-02 1.439 1 1
FGFR2 alternative splicing R-HSA-6803529 3.678292e-02 1.434 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.678292e-02 1.434 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 3.715892e-02 1.430 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 3.719601e-02 1.430 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 3.882780e-02 1.411 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.882780e-02 1.411 0 0
Regulation of pyruvate metabolism R-HSA-9861718 3.882780e-02 1.411 0 0
Manipulation of host energy metabolism R-HSA-9636667 4.344904e-02 1.362 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 4.267445e-02 1.370 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 4.267445e-02 1.370 0 0
ARMS-mediated activation R-HSA-170984 4.442039e-02 1.352 0 0
ALK mutants bind TKIs R-HSA-9700645 4.442039e-02 1.352 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 4.091034e-02 1.388 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 4.312063e-02 1.365 0 0
Regulation of signaling by CBL R-HSA-912631 5.095817e-02 1.293 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 5.095817e-02 1.293 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 5.095817e-02 1.293 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 3.953487e-02 1.403 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 3.953487e-02 1.403 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 4.323248e-02 1.364 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.982670e-02 1.400 0 0
Regulation of PTEN gene transcription R-HSA-8943724 4.034059e-02 1.394 0 0
PTEN Regulation R-HSA-6807070 4.168684e-02 1.380 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 5.079282e-02 1.294 0 0
RAF activation R-HSA-5673000 3.953487e-02 1.403 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 3.953487e-02 1.403 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 4.337308e-02 1.363 0 0
MyD88-independent TLR4 cascade R-HSA-166166 5.250074e-02 1.280 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 5.250074e-02 1.280 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 4.312063e-02 1.365 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.344904e-02 1.362 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.296453e-02 1.367 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 5.216748e-02 1.283 0 0
G2/M DNA damage checkpoint R-HSA-69473 4.033556e-02 1.394 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 4.156930e-02 1.381 0 0
MAP kinase activation R-HSA-450294 4.432455e-02 1.353 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 4.442039e-02 1.352 0 0
Mitophagy R-HSA-5205647 3.953487e-02 1.403 0 0
Ca-dependent events R-HSA-111996 5.216748e-02 1.283 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 4.442039e-02 1.352 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 4.994782e-02 1.301 0 0
NRIF signals cell death from the nucleus R-HSA-205043 4.994782e-02 1.301 0 0
Signaling by NOTCH2 R-HSA-1980145 3.953487e-02 1.403 0 0
Muscle contraction R-HSA-397014 3.955240e-02 1.403 0 0
Signaling by NOTCH3 R-HSA-9012852 4.850870e-02 1.314 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.255773e-02 1.279 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 5.255773e-02 1.279 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 5.275777e-02 1.278 0 0
Degradation of CDH1 R-HSA-9766229 5.304585e-02 1.275 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 5.309867e-02 1.275 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.309867e-02 1.275 0 0
Signaling by PTK6 R-HSA-8848021 5.309867e-02 1.275 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.330134e-02 1.273 0 0
TNF signaling R-HSA-75893 5.330134e-02 1.273 0 0
Signaling by FGFR1 R-HSA-5654736 5.330134e-02 1.273 0 0
Ion homeostasis R-HSA-5578775 5.330134e-02 1.273 0 0
NRAGE signals death through JNK R-HSA-193648 5.330134e-02 1.273 0 0
Trafficking of AMPA receptors R-HSA-399719 5.401012e-02 1.268 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.401012e-02 1.268 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 5.418451e-02 1.266 0 0
HCMV Early Events R-HSA-9609690 5.444833e-02 1.264 0 0
Clathrin-mediated endocytosis R-HSA-8856828 5.582793e-02 1.253 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 5.585299e-02 1.253 0 0
Translation R-HSA-72766 5.588342e-02 1.253 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 5.603185e-02 1.252 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 5.631129e-02 1.249 0 0
Regulation of CDH11 function R-HSA-9762292 5.631129e-02 1.249 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 7.198223e-02 1.143 0 0
Regulation of TP53 Expression R-HSA-6804754 7.198223e-02 1.143 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 7.198223e-02 1.143 0 0
Regulation of cortical dendrite branching R-HSA-8985801 7.198223e-02 1.143 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 7.198223e-02 1.143 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 7.198223e-02 1.143 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 7.198223e-02 1.143 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 7.198223e-02 1.143 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 7.198223e-02 1.143 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 7.198223e-02 1.143 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 7.198223e-02 1.143 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 7.198223e-02 1.143 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 7.198223e-02 1.143 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 5.889667e-02 1.230 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.889667e-02 1.230 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.889667e-02 1.230 0 0
CREB phosphorylation R-HSA-199920 7.757408e-02 1.110 0 0
Signaling by LTK in cancer R-HSA-9842640 7.757408e-02 1.110 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 6.973830e-02 1.157 0 0
Signaling by APC mutants R-HSA-4839744 6.973830e-02 1.157 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 6.973830e-02 1.157 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 6.973830e-02 1.157 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 6.973830e-02 1.157 0 0
Activation of RAC1 R-HSA-428540 8.465188e-02 1.072 0 0
Translesion synthesis by REV1 R-HSA-110312 6.006572e-02 1.221 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 6.006572e-02 1.221 0 0
Translesion synthesis by POLI R-HSA-5656121 7.126148e-02 1.147 0 0
Phosphorylation of the APC/C R-HSA-176412 7.126148e-02 1.147 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 7.126148e-02 1.147 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 5.961176e-02 1.225 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 5.961176e-02 1.225 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 5.961176e-02 1.225 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 5.961176e-02 1.225 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 8.352016e-02 1.078 0 0
Translesion synthesis by POLK R-HSA-5655862 8.352016e-02 1.078 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 7.938252e-02 1.100 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 7.938252e-02 1.100 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 6.536225e-02 1.185 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 7.414207e-02 1.130 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.540410e-02 1.069 0 0
mRNA 3'-end processing R-HSA-72187 7.038649e-02 1.153 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 7.038649e-02 1.153 0 0
Dual incision in TC-NER R-HSA-6782135 6.382259e-02 1.195 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 7.688704e-02 1.114 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 7.562513e-02 1.121 0 0
Protein ubiquitination R-HSA-8852135 7.779288e-02 1.109 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 5.961176e-02 1.225 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 6.860688e-02 1.164 0 0
Assembly of the pre-replicative complex R-HSA-68867 6.609508e-02 1.180 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 8.352016e-02 1.078 0 0
Diseases of mitotic cell cycle R-HSA-9675126 6.103509e-02 1.214 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 6.314681e-02 1.200 0 0
Myogenesis R-HSA-525793 6.536225e-02 1.185 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 8.506086e-02 1.070 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 6.006572e-02 1.221 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 5.708144e-02 1.244 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 5.981686e-02 1.223 0 0
Neurexins and neuroligins R-HSA-6794361 7.038649e-02 1.153 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.934733e-02 1.100 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 5.981686e-02 1.223 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 5.981686e-02 1.223 0 0
Activation of ATR in response to replication stress R-HSA-176187 6.860688e-02 1.164 0 0
Synthesis of DNA R-HSA-69239 7.022929e-02 1.153 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.469514e-02 1.127 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 6.361414e-02 1.196 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.625349e-02 1.118 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.388303e-02 1.076 0 0
Sema4D in semaphorin signaling R-HSA-400685 5.724307e-02 1.242 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 8.352016e-02 1.078 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.540410e-02 1.069 0 0
Gene expression (Transcription) R-HSA-74160 6.023138e-02 1.220 1 0
Hedgehog 'on' state R-HSA-5632684 5.708144e-02 1.244 0 0
Signaling by Hedgehog R-HSA-5358351 6.141547e-02 1.212 0 0
Signaling by AXIN mutants R-HSA-4839735 8.465188e-02 1.072 0 0
Mitochondrial calcium ion transport R-HSA-8949215 7.938252e-02 1.100 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 7.938252e-02 1.100 0 0
Early Phase of HIV Life Cycle R-HSA-162594 6.908704e-02 1.161 0 0
HCMV Infection R-HSA-9609646 7.451127e-02 1.128 0 0
DAG and IP3 signaling R-HSA-1489509 7.067713e-02 1.151 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 5.766873e-02 1.239 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 7.067713e-02 1.151 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 7.067713e-02 1.151 0 0
Circadian clock R-HSA-9909396 6.389573e-02 1.195 0 0
Pyruvate metabolism R-HSA-70268 6.819886e-02 1.166 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 6.908704e-02 1.161 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 6.536225e-02 1.185 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 6.860688e-02 1.164 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 6.908704e-02 1.161 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 7.414207e-02 1.130 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 6.860688e-02 1.164 0 0
Viral Messenger RNA Synthesis R-HSA-168325 8.201582e-02 1.086 0 0
Glycolysis R-HSA-70171 6.831796e-02 1.165 0 0
Interferon gamma signaling R-HSA-877300 8.544739e-02 1.068 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 7.938252e-02 1.100 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.938252e-02 1.100 0 0
Selenoamino acid metabolism R-HSA-2408522 7.421614e-02 1.130 0 0
SARS-CoV-2 Infection R-HSA-9694516 5.789596e-02 1.237 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.572168e-02 1.067 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 8.572168e-02 1.067 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.572168e-02 1.067 0 0
Viral Infection Pathways R-HSA-9824446 8.685124e-02 1.061 0 0
Vesicle-mediated transport R-HSA-5653656 8.691653e-02 1.061 0 0
Opioid Signalling R-HSA-111885 8.768447e-02 1.057 0 0
TCF dependent signaling in response to WNT R-HSA-201681 8.988562e-02 1.046 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 9.048973e-02 1.043 0 0
SARS-CoV Infections R-HSA-9679506 9.265070e-02 1.033 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 9.281650e-02 1.032 0 0
Interleukin-17 signaling R-HSA-448424 9.281650e-02 1.032 0 0
Signaling by Nuclear Receptors R-HSA-9006931 9.305625e-02 1.031 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 9.367891e-02 1.028 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 9.367891e-02 1.028 0 0
Termination of translesion DNA synthesis R-HSA-5656169 9.367891e-02 1.028 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.419162e-02 1.026 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.419162e-02 1.026 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.419162e-02 1.026 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 9.462856e-02 1.024 0 0
Regulation of Apoptosis R-HSA-169911 9.462856e-02 1.024 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 9.462856e-02 1.024 0 0
Oncogene Induced Senescence R-HSA-2559585 9.462856e-02 1.024 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 9.578524e-02 1.019 0 0
Semaphorin interactions R-HSA-373755 9.578524e-02 1.019 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.615807e-02 1.017 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 9.681541e-02 1.014 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.681541e-02 1.014 0 0
Glycogen storage diseases R-HSA-3229121 9.681541e-02 1.014 0 0
Signaling by WNT R-HSA-195721 9.707171e-02 1.013 0 0
Signaling by Interleukins R-HSA-449147 9.751329e-02 1.011 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 9.804207e-02 1.009 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 9.848777e-02 1.007 0 0
Nucleotide Excision Repair R-HSA-5696398 9.857825e-02 1.006 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.009815e-01 0.996 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.010973e-01 0.995 0 0
Growth hormone receptor signaling R-HSA-982772 1.023936e-01 0.990 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 1.028273e-01 0.988 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 1.037054e-01 0.984 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.037054e-01 0.984 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.037054e-01 0.984 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.037054e-01 0.984 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 1.043979e-01 0.981 0 0
Calmodulin induced events R-HSA-111933 1.043979e-01 0.981 0 0
CaM pathway R-HSA-111997 1.043979e-01 0.981 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.044227e-01 0.981 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.044227e-01 0.981 0 0
FasL/ CD95L signaling R-HSA-75157 1.048857e-01 0.979 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.048857e-01 0.979 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.048857e-01 0.979 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.068347e-01 0.971 0 0
Signaling by MET R-HSA-6806834 1.097702e-01 0.960 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.111105e-01 0.954 0 0
Response of Mtb to phagocytosis R-HSA-9637690 1.125368e-01 0.949 0 0
Degradation of DVL R-HSA-4641258 1.147043e-01 0.940 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 1.150730e-01 0.939 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.150730e-01 0.939 0 0
Neurodegenerative Diseases R-HSA-8863678 1.150730e-01 0.939 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.158009e-01 0.936 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.158009e-01 0.936 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 1.186395e-01 0.926 0 0
Frs2-mediated activation R-HSA-170968 1.186395e-01 0.926 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.186395e-01 0.926 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 1.186395e-01 0.926 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.213897e-01 0.916 0 0
RSK activation R-HSA-444257 1.213897e-01 0.916 0 0
Sodium/Proton exchangers R-HSA-425986 1.213897e-01 0.916 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.213897e-01 0.916 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.219306e-01 0.914 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.220439e-01 0.913 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 1.224004e-01 0.912 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.224004e-01 0.912 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.228145e-01 0.911 0 0
Translesion Synthesis by POLH R-HSA-110320 1.263595e-01 0.898 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.272567e-01 0.895 0 0
G0 and Early G1 R-HSA-1538133 1.277967e-01 0.893 0 0
Orc1 removal from chromatin R-HSA-68949 1.282120e-01 0.892 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 1.282120e-01 0.892 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 1.285009e-01 0.891 0 0
Long-term potentiation R-HSA-9620244 1.285009e-01 0.891 0 0
TCR signaling R-HSA-202403 1.293817e-01 0.888 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.326142e-01 0.877 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.326142e-01 0.877 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.326142e-01 0.877 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.326142e-01 0.877 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.326142e-01 0.877 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.336600e-01 0.874 0 0
Regulated Necrosis R-HSA-5218859 1.359390e-01 0.867 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.368825e-01 0.864 0 0
Stabilization of p53 R-HSA-69541 1.368825e-01 0.864 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 1.368825e-01 0.864 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.375242e-01 0.862 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 1.375242e-01 0.862 0 0
Regulation of KIT signaling R-HSA-1433559 1.375242e-01 0.862 0 0
Meiotic synapsis R-HSA-1221632 1.380444e-01 0.860 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.380444e-01 0.860 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.966614e-01 0.706 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.966614e-01 0.706 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.966614e-01 0.706 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.966614e-01 0.706 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.966614e-01 0.706 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.966614e-01 0.706 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 1.966614e-01 0.706 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.966614e-01 0.706 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 1.966614e-01 0.706 0 0
TGFBR2 MSI Frameshift Mutants in Cancer R-HSA-3642279 1.966614e-01 0.706 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 1.966614e-01 0.706 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 1.966614e-01 0.706 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.409471e-01 0.851 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.409471e-01 0.851 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.409471e-01 0.851 0 0
Signaling by MAP2K mutants R-HSA-9652169 1.409471e-01 0.851 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.791585e-01 0.747 0 0
Pentose phosphate pathway disease R-HSA-6791465 2.186868e-01 0.660 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.186868e-01 0.660 0 0
Signaling by MAPK mutants R-HSA-9652817 2.186868e-01 0.660 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.720978e-01 0.764 0 0
2-LTR circle formation R-HSA-164843 1.720978e-01 0.764 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.720978e-01 0.764 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.588483e-01 0.587 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 2.588483e-01 0.587 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.588483e-01 0.587 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.575236e-01 0.803 0 0
G beta:gamma signalling through BTK R-HSA-8964315 1.575236e-01 0.803 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.425085e-01 0.846 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 2.275694e-01 0.643 0 0
ERK/MAPK targets R-HSA-198753 1.594970e-01 0.797 0 0
Disorders of Developmental Biology R-HSA-9675151 2.003845e-01 0.698 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.003845e-01 0.698 0 0
Disorders of Nervous System Development R-HSA-9697154 2.564560e-01 0.591 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.564560e-01 0.591 0 0
Pervasive developmental disorders R-HSA-9005895 2.564560e-01 0.591 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.574690e-01 0.803 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.229959e-01 0.652 0 0
Ephrin signaling R-HSA-3928664 2.462264e-01 0.609 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 2.462264e-01 0.609 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.487252e-01 0.828 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.434654e-01 0.843 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.344647e-01 0.630 0 0
Deadenylation of mRNA R-HSA-429947 2.344647e-01 0.630 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 1.962162e-01 0.707 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.420061e-01 0.848 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 2.290546e-01 0.640 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 2.290546e-01 0.640 0 0
Nucleosome assembly R-HSA-774815 2.290546e-01 0.640 0 0
NCAM signaling for neurite out-growth R-HSA-375165 2.422893e-01 0.616 0 0
RNA Polymerase III Transcription R-HSA-74158 1.962162e-01 0.707 0 0
EPH-Ephrin signaling R-HSA-2682334 1.577129e-01 0.802 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 1.487252e-01 0.828 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 1.487252e-01 0.828 0 0
Regulation of PTEN stability and activity R-HSA-8948751 2.297399e-01 0.639 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.055932e-01 0.687 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.685280e-01 0.571 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 2.275694e-01 0.643 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.889888e-01 0.724 0 0
Integration of provirus R-HSA-162592 2.275694e-01 0.643 0 0
Repression of WNT target genes R-HSA-4641265 2.564560e-01 0.591 0 0
Rap1 signalling R-HSA-392517 2.699517e-01 0.569 0 0
RNA Polymerase I Transcription R-HSA-73864 1.559443e-01 0.807 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.720978e-01 0.764 0 0
G-protein activation R-HSA-202040 1.594970e-01 0.797 0 0
Metalloprotease DUBs R-HSA-5689901 1.426452e-01 0.846 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 2.751125e-01 0.560 0 0
Meiosis R-HSA-1500620 2.254717e-01 0.647 0 0
Muscarinic acetylcholine receptors R-HSA-390648 1.791585e-01 0.747 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 1.425085e-01 0.846 0 0
Nuclear RNA decay R-HSA-9930044 1.403899e-01 0.853 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.751125e-01 0.560 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.905804e-01 0.720 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 2.159887e-01 0.666 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 2.545888e-01 0.594 0 0
Ca2+ pathway R-HSA-4086398 1.838788e-01 0.735 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.758284e-01 0.559 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 2.143096e-01 0.669 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.574690e-01 0.803 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.810993e-01 0.742 0 0
Interleukin-1 signaling R-HSA-9020702 2.516151e-01 0.599 0 0
G1 Phase R-HSA-69236 2.146825e-01 0.668 0 0
Cyclin D associated events in G1 R-HSA-69231 2.146825e-01 0.668 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 2.143096e-01 0.669 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 2.411117e-01 0.618 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.815005e-01 0.741 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.141181e-01 0.669 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 2.055932e-01 0.687 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 2.411117e-01 0.618 0 0
Inositol transporters R-HSA-429593 1.791585e-01 0.747 0 0
Pyrophosphate hydrolysis R-HSA-71737 1.791585e-01 0.747 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 2.186868e-01 0.660 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 1.815005e-01 0.741 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 1.815005e-01 0.741 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.564560e-01 0.591 0 0
Signaling by WNT in cancer R-HSA-4791275 2.402444e-01 0.619 0 0
DNA Replication R-HSA-69306 2.521007e-01 0.598 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 2.226955e-01 0.652 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 2.516151e-01 0.599 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 2.006693e-01 0.698 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.751125e-01 0.560 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.485280e-01 0.828 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 1.460161e-01 0.836 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 2.186868e-01 0.660 0 0
Complex III assembly R-HSA-9865881 2.344647e-01 0.630 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 2.699517e-01 0.569 0 0
HATs acetylate histones R-HSA-3214847 1.579787e-01 0.801 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.782177e-01 0.749 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.782177e-01 0.749 0 0
Signal attenuation R-HSA-74749 1.720978e-01 0.764 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.588483e-01 0.587 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.403899e-01 0.853 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 2.344647e-01 0.630 0 0
Signalling to ERKs R-HSA-187687 1.815005e-01 0.741 0 0
NOD1/2 Signaling Pathway R-HSA-168638 1.672699e-01 0.777 0 0
Glycogen synthesis R-HSA-3322077 1.425085e-01 0.846 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.654467e-01 0.576 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.258619e-01 0.646 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.635264e-01 0.786 0 0
G alpha (z) signalling events R-HSA-418597 2.573569e-01 0.589 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.740356e-01 0.562 0 0
Polo-like kinase mediated events R-HSA-156711 2.462264e-01 0.609 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.962162e-01 0.707 0 0
PLC beta mediated events R-HSA-112043 1.420061e-01 0.848 0 0
Glycogen metabolism R-HSA-8982491 2.592268e-01 0.586 0 0
G1/S Transition R-HSA-69206 1.428630e-01 0.845 0 0
Signaling by TGFB family members R-HSA-9006936 2.400707e-01 0.620 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 1.966614e-01 0.706 0 0
Inhibition of PKR R-HSA-169131 1.966614e-01 0.706 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.460161e-01 0.836 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 2.564560e-01 0.591 0 0
mTORC1-mediated signalling R-HSA-166208 1.957234e-01 0.708 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.462264e-01 0.609 0 0
Presynaptic function of Kainate receptors R-HSA-500657 2.462264e-01 0.609 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.672699e-01 0.777 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 1.546433e-01 0.811 0 0
Degradation of AXIN R-HSA-4641257 2.113832e-01 0.675 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 2.113832e-01 0.675 0 0
RMTs methylate histone arginines R-HSA-3214858 2.146825e-01 0.668 0 0
PCP/CE pathway R-HSA-4086400 2.386129e-01 0.622 0 0
Heme signaling R-HSA-9707616 1.517389e-01 0.819 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 2.269655e-01 0.644 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 2.003845e-01 0.698 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 2.564560e-01 0.591 0 0
Downstream signal transduction R-HSA-186763 2.226955e-01 0.652 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.474022e-01 0.831 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.460161e-01 0.836 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.772588e-01 0.751 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.169404e-01 0.664 0 0
Gene Silencing by RNA R-HSA-211000 1.657597e-01 0.781 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.429261e-01 0.615 0 0
G-protein mediated events R-HSA-112040 2.051809e-01 0.688 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.542240e-01 0.812 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.186868e-01 0.660 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.993683e-01 0.700 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.575236e-01 0.803 0 0
Vpu mediated degradation of CD4 R-HSA-180534 1.535566e-01 0.814 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.581877e-01 0.588 0 0
Signaling by NOTCH1 R-HSA-1980143 1.384247e-01 0.859 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.720978e-01 0.764 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.588483e-01 0.587 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 2.290546e-01 0.640 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.592268e-01 0.586 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 2.592268e-01 0.586 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 2.758284e-01 0.559 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 2.686327e-01 0.571 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.485280e-01 0.828 0 0
Activation of BH3-only proteins R-HSA-114452 2.055932e-01 0.687 0 0
Signaling by NOTCH4 R-HSA-9013694 1.943230e-01 0.711 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.575236e-01 0.803 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.574690e-01 0.803 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 2.764721e-01 0.558 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.740356e-01 0.562 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 1.594970e-01 0.797 0 0
Glucose metabolism R-HSA-70326 1.972386e-01 0.705 0 0
Inositol phosphate metabolism R-HSA-1483249 1.431174e-01 0.844 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 1.672699e-01 0.777 0 0
Plasma lipoprotein clearance R-HSA-8964043 2.429261e-01 0.615 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 2.758284e-01 0.559 0 0
Diseases of DNA repair R-HSA-9675135 1.434654e-01 0.843 0 0
Nephron development R-HSA-9831926 2.462264e-01 0.609 0 0
Suppression of phagosomal maturation R-HSA-9637687 2.751125e-01 0.560 0 0
Unfolded Protein Response (UPR) R-HSA-381119 2.693904e-01 0.570 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.658557e-01 0.780 0 0
FLT3 Signaling R-HSA-9607240 1.610466e-01 0.793 0 0
IRE1alpha activates chaperones R-HSA-381070 2.235117e-01 0.651 0 0
Regulation of BACH1 activity R-HSA-9708530 1.785183e-01 0.748 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.698001e-01 0.770 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 1.889888e-01 0.724 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.799817e-01 0.553 0 0
IKBKB deficiency causes SCID R-HSA-5602636 2.799817e-01 0.553 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 2.799817e-01 0.553 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 2.799817e-01 0.553 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 2.799817e-01 0.553 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 2.799817e-01 0.553 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.799817e-01 0.553 0 0
Defective HK1 causes hexokinase deficiency (HK deficiency) R-HSA-5619056 2.799817e-01 0.553 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 2.799817e-01 0.553 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 2.799817e-01 0.553 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.799817e-01 0.553 0 0
Nef mediated downregulation of CD28 cell surface expression R-HSA-164939 2.799817e-01 0.553 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.799817e-01 0.553 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.799817e-01 0.553 0 0
Defective SERPING1 causes hereditary angioedema R-HSA-9657689 2.799817e-01 0.553 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.799817e-01 0.553 0 0
Cellular response to hypoxia R-HSA-1234174 2.821287e-01 0.550 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.825355e-01 0.549 0 0
Signaling by NTRKs R-HSA-166520 2.825355e-01 0.549 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.833150e-01 0.548 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 2.882907e-01 0.540 0 0
MAPK family signaling cascades R-HSA-5683057 2.918395e-01 0.535 0 0
Degradation of CRY and PER proteins R-HSA-9932298 2.926916e-01 0.534 0 0
Signaling by FGFR1 in disease R-HSA-5655302 2.926916e-01 0.534 0 0
Downstream TCR signaling R-HSA-202424 2.934116e-01 0.533 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 2.940509e-01 0.532 0 0
Protein hydroxylation R-HSA-9629569 2.940509e-01 0.532 0 0
Signal transduction by L1 R-HSA-445144 2.940509e-01 0.532 0 0
Signaling by NODAL R-HSA-1181150 2.940509e-01 0.532 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 2.950446e-01 0.530 0 0
Calnexin/calreticulin cycle R-HSA-901042 2.950446e-01 0.530 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 2.959595e-01 0.529 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.959595e-01 0.529 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 2.959595e-01 0.529 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 2.990869e-01 0.524 0 0
TRIF-mediated programmed cell death R-HSA-2562578 2.990869e-01 0.524 0 0
SOS-mediated signalling R-HSA-112412 2.990869e-01 0.524 0 0
Recycling of eIF2:GDP R-HSA-72731 2.990869e-01 0.524 0 0
Disinhibition of SNARE formation R-HSA-114516 2.990869e-01 0.524 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.990869e-01 0.524 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 2.990869e-01 0.524 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.990869e-01 0.524 0 0
IFNG signaling activates MAPKs R-HSA-9732724 2.990869e-01 0.524 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 2.990869e-01 0.524 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 2.990869e-01 0.524 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 3.005810e-01 0.522 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 3.041013e-01 0.517 0 0
MTOR signalling R-HSA-165159 3.097767e-01 0.509 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.097767e-01 0.509 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.111834e-01 0.507 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.137504e-01 0.503 0 0
Prolactin receptor signaling R-HSA-1170546 3.153860e-01 0.501 0 0
Signaling by FGFR4 in disease R-HSA-5655291 3.153860e-01 0.501 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 3.170546e-01 0.499 0 0
Pyroptosis R-HSA-5620971 3.170546e-01 0.499 0 0
UCH proteinases R-HSA-5689603 3.173013e-01 0.499 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 3.184073e-01 0.497 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 3.184073e-01 0.497 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.184073e-01 0.497 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 3.184073e-01 0.497 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 3.211813e-01 0.493 0 0
Neutrophil degranulation R-HSA-6798695 3.220239e-01 0.492 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.236704e-01 0.490 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 3.270442e-01 0.485 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 3.319004e-01 0.479 0 0
RET signaling R-HSA-8853659 3.328420e-01 0.478 0 0
G1/S-Specific Transcription R-HSA-69205 3.328420e-01 0.478 0 0
RUNX2 regulates bone development R-HSA-8941326 3.328420e-01 0.478 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 3.372338e-01 0.472 0 0
Glucagon-type ligand receptors R-HSA-420092 3.383246e-01 0.471 0 0
Regulation by c-FLIP R-HSA-3371378 3.389551e-01 0.470 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 3.389551e-01 0.470 0 0
Dimerization of procaspase-8 R-HSA-69416 3.389551e-01 0.470 0 0
phospho-PLA2 pathway R-HSA-111995 3.389551e-01 0.470 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.389551e-01 0.470 0 0
MET receptor recycling R-HSA-8875656 3.389551e-01 0.470 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.389551e-01 0.470 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.389551e-01 0.470 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.389551e-01 0.470 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.429104e-01 0.465 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.444548e-01 0.463 0 0
Processive synthesis on the lagging strand R-HSA-69183 3.450250e-01 0.462 0 0
DCC mediated attractive signaling R-HSA-418885 3.450250e-01 0.462 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 3.450250e-01 0.462 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 3.450250e-01 0.462 0 0
Biotin transport and metabolism R-HSA-196780 3.450250e-01 0.462 0 0
Signaling by Activin R-HSA-1502540 3.450250e-01 0.462 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 3.450250e-01 0.462 0 0
Adipogenesis R-HSA-9843745 3.490635e-01 0.457 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 3.493979e-01 0.457 0 0
RNA Polymerase II Transcription R-HSA-73857 3.540257e-01 0.451 1 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.546647e-01 0.450 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.546647e-01 0.450 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.546647e-01 0.450 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.546647e-01 0.450 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.546647e-01 0.450 0 0
Signaling by RAS GAP mutants R-HSA-9753510 3.546647e-01 0.450 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.546647e-01 0.450 0 0
Defective factor XII causes hereditary angioedema R-HSA-9657688 3.546647e-01 0.450 0 0
Signalling to ERK5 R-HSA-198765 3.546647e-01 0.450 0 0
C6 deamination of adenosine R-HSA-75102 3.546647e-01 0.450 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.579798e-01 0.446 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 3.596989e-01 0.444 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.596989e-01 0.444 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.605330e-01 0.443 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 3.619701e-01 0.441 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.626841e-01 0.440 0 0
Transmission across Chemical Synapses R-HSA-112315 3.651450e-01 0.438 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 3.663773e-01 0.436 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 3.674556e-01 0.435 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.729711e-01 0.428 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 3.745424e-01 0.426 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 3.745424e-01 0.426 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.745424e-01 0.426 0 0
Lipophagy R-HSA-9613354 3.780969e-01 0.422 0 0
WNT mediated activation of DVL R-HSA-201688 3.780969e-01 0.422 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 3.780969e-01 0.422 0 0
CASP8 activity is inhibited R-HSA-5218900 3.780969e-01 0.422 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 3.780969e-01 0.422 0 0
Unwinding of DNA R-HSA-176974 3.780969e-01 0.422 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 3.780969e-01 0.422 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 3.780969e-01 0.422 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.780969e-01 0.422 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.807435e-01 0.419 0 0
Potential therapeutics for SARS R-HSA-9679191 3.839818e-01 0.416 0 0
HDACs deacetylate histones R-HSA-3214815 3.859737e-01 0.413 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.904007e-01 0.408 0 0
Ion transport by P-type ATPases R-HSA-936837 3.910546e-01 0.408 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 3.919455e-01 0.407 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 3.919455e-01 0.407 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.919455e-01 0.407 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 4.023151e-01 0.395 0 0
DNA strand elongation R-HSA-69190 4.024927e-01 0.395 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 4.037840e-01 0.394 0 0
Synthesis of PG R-HSA-1483148 4.037840e-01 0.394 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 4.037840e-01 0.394 0 0
Chromosome Maintenance R-HSA-73886 4.093082e-01 0.388 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.096221e-01 0.388 0 0
HIV Transcription Elongation R-HSA-167169 4.096221e-01 0.388 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.096221e-01 0.388 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 4.096221e-01 0.388 0 0
Diseases of Immune System R-HSA-5260271 4.096221e-01 0.388 0 0
Integration of energy metabolism R-HSA-163685 4.118875e-01 0.385 0 0
Metal ion SLC transporters R-HSA-425410 4.147705e-01 0.382 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.162343e-01 0.381 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.162343e-01 0.381 0 0
Regulation of the apoptosome activity R-HSA-9627069 4.162343e-01 0.381 0 0
Signaling by Leptin R-HSA-2586552 4.162343e-01 0.381 0 0
Formation of apoptosome R-HSA-111458 4.162343e-01 0.381 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 4.162898e-01 0.381 0 0
Thromboxane signalling through TP receptor R-HSA-428930 4.162898e-01 0.381 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.162898e-01 0.381 0 0
PIP3 activates AKT signaling R-HSA-1257604 4.204004e-01 0.376 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 4.216052e-01 0.375 0 0
PLC-gamma1 signalling R-HSA-167021 4.216052e-01 0.375 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 4.216052e-01 0.375 0 0
Axonal growth stimulation R-HSA-209563 4.216052e-01 0.375 0 0
MET activates PTPN11 R-HSA-8865999 4.216052e-01 0.375 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 4.216052e-01 0.375 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 4.216052e-01 0.375 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.216052e-01 0.375 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.216052e-01 0.375 0 0
Defective ABCC2 causes DJS R-HSA-5679001 4.216052e-01 0.375 0 0
Intracellular oxygen transport R-HSA-8981607 4.216052e-01 0.375 0 0
Histamine receptors R-HSA-390650 4.216052e-01 0.375 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 4.216809e-01 0.375 0 0
Integrin signaling R-HSA-354192 4.237870e-01 0.373 0 0
G-protein beta:gamma signalling R-HSA-397795 4.237870e-01 0.373 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 4.237870e-01 0.373 0 0
Iron uptake and transport R-HSA-917937 4.240908e-01 0.373 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 4.287851e-01 0.368 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 4.310298e-01 0.365 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 4.326145e-01 0.364 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 4.404059e-01 0.356 0 0
G protein gated Potassium channels R-HSA-1296059 4.404059e-01 0.356 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 4.404059e-01 0.356 0 0
TGFBR3 expression R-HSA-9839394 4.404059e-01 0.356 0 0
HDMs demethylate histones R-HSA-3214842 4.404059e-01 0.356 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 4.421714e-01 0.354 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 4.512258e-01 0.346 0 0
Transcription of the HIV genome R-HSA-167172 4.522273e-01 0.345 0 0
Formation of the posterior neural plate R-HSA-9832991 4.531547e-01 0.344 0 0
vRNP Assembly R-HSA-192905 4.531547e-01 0.344 0 0
Suppression of apoptosis R-HSA-9635465 4.531547e-01 0.344 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 4.534694e-01 0.343 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.609165e-01 0.336 0 0
GAB1 signalosome R-HSA-180292 4.609165e-01 0.336 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.609165e-01 0.336 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 4.609165e-01 0.336 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 4.609165e-01 0.336 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 4.609165e-01 0.336 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 4.609165e-01 0.336 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.642188e-01 0.333 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 4.651972e-01 0.332 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 4.658859e-01 0.332 0 0
Signal amplification R-HSA-392518 4.658859e-01 0.332 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 4.658859e-01 0.332 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 4.667696e-01 0.331 0 0
Hedgehog ligand biogenesis R-HSA-5358346 4.672186e-01 0.330 0 0
tRNA Aminoacylation R-HSA-379724 4.674030e-01 0.330 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.674159e-01 0.330 0 0
MITF-M-dependent gene expression R-HSA-9856651 4.746874e-01 0.324 0 0
MTF1 activates gene expression R-HSA-5660489 4.816054e-01 0.317 0 0
Regulation of gap junction activity R-HSA-191650 4.816054e-01 0.317 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 4.816054e-01 0.317 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.816054e-01 0.317 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.816054e-01 0.317 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.816054e-01 0.317 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.816054e-01 0.317 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 4.816054e-01 0.317 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.816054e-01 0.317 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.816054e-01 0.317 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.816054e-01 0.317 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.816054e-01 0.317 0 0
Sensory processing of sound R-HSA-9659379 4.816058e-01 0.317 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 4.825204e-01 0.316 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 4.834753e-01 0.316 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 4.844731e-01 0.315 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.876613e-01 0.312 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 4.876613e-01 0.312 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 4.876613e-01 0.312 0 0
Cristae formation R-HSA-8949613 4.876613e-01 0.312 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 4.876613e-01 0.312 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 4.885900e-01 0.311 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 4.885900e-01 0.311 0 0
The NLRP3 inflammasome R-HSA-844456 4.885900e-01 0.311 0 0
ERKs are inactivated R-HSA-202670 4.887003e-01 0.311 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 4.887003e-01 0.311 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.887003e-01 0.311 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.887003e-01 0.311 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 4.887003e-01 0.311 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 4.887003e-01 0.311 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.890703e-01 0.311 0 0
Diseases of programmed cell death R-HSA-9645723 4.942572e-01 0.306 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 4.958137e-01 0.305 0 0
Mitochondrial protein import R-HSA-1268020 4.994195e-01 0.302 0 0
Signaling by PDGF R-HSA-186797 4.994195e-01 0.302 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 5.015653e-01 0.300 0 0
RSV-host interactions R-HSA-9833110 5.038490e-01 0.298 0 0
Netrin-1 signaling R-HSA-373752 5.040454e-01 0.298 0 0
ER-Phagosome pathway R-HSA-1236974 5.077005e-01 0.294 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 5.099200e-01 0.292 0 0
Telomere Extension By Telomerase R-HSA-171319 5.106733e-01 0.292 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 5.106733e-01 0.292 0 0
Formation of the Early Elongation Complex R-HSA-113418 5.106733e-01 0.292 0 0
HIV elongation arrest and recovery R-HSA-167287 5.106733e-01 0.292 0 0
Pausing and recovery of HIV elongation R-HSA-167290 5.106733e-01 0.292 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 5.106733e-01 0.292 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 5.106733e-01 0.292 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 5.155506e-01 0.288 0 0
Formation of definitive endoderm R-HSA-9823730 5.155506e-01 0.288 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 5.217832e-01 0.283 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 5.223321e-01 0.282 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 5.223321e-01 0.282 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.227591e-01 0.282 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 5.227591e-01 0.282 0 0
Scavenging by Class F Receptors R-HSA-3000484 5.227591e-01 0.282 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.227591e-01 0.282 0 0
MET activates RAS signaling R-HSA-8851805 5.227591e-01 0.282 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 5.227591e-01 0.282 0 0
Toll-like Receptor Cascades R-HSA-168898 5.275589e-01 0.278 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 5.282635e-01 0.277 0 0
Signaling by Erythropoietin R-HSA-9006335 5.332023e-01 0.273 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 5.353847e-01 0.271 0 0
IRS activation R-HSA-74713 5.353847e-01 0.271 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.353847e-01 0.271 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.353847e-01 0.271 0 0
Defective F9 activation R-HSA-9673221 5.353847e-01 0.271 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 5.353847e-01 0.271 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.353847e-01 0.271 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.353847e-01 0.271 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.353847e-01 0.271 0 0
Reelin signalling pathway R-HSA-8866376 5.353847e-01 0.271 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.353847e-01 0.271 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.353847e-01 0.271 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 5.353847e-01 0.271 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 5.408634e-01 0.267 0 0
Signaling by ERBB4 R-HSA-1236394 5.417197e-01 0.266 0 0
Lagging Strand Synthesis R-HSA-69186 5.417292e-01 0.266 0 0
Basigin interactions R-HSA-210991 5.417292e-01 0.266 0 0
Neuronal System R-HSA-112316 5.487625e-01 0.261 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 5.516140e-01 0.258 0 0
Activation of the pre-replicative complex R-HSA-68962 5.552027e-01 0.256 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 5.552027e-01 0.256 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 5.552570e-01 0.256 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.552570e-01 0.256 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 5.552570e-01 0.256 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.552570e-01 0.256 0 0
Processing of SMDT1 R-HSA-8949664 5.552570e-01 0.256 0 0
Formation of axial mesoderm R-HSA-9796292 5.552570e-01 0.256 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.552570e-01 0.256 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 5.552570e-01 0.256 0 0
ABC-family proteins mediated transport R-HSA-382556 5.561874e-01 0.255 0 0
Signaling by NOTCH R-HSA-157118 5.606754e-01 0.251 0 0
RAS processing R-HSA-9648002 5.660944e-01 0.247 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 5.670700e-01 0.246 0 0
Mitochondrial biogenesis R-HSA-1592230 5.719056e-01 0.243 0 0
NGF-stimulated transcription R-HSA-9031628 5.754401e-01 0.240 0 0
Developmental Biology R-HSA-1266738 5.818442e-01 0.235 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.835876e-01 0.234 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.835876e-01 0.234 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.835876e-01 0.234 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.835876e-01 0.234 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.835876e-01 0.234 0 0
TRAIL signaling R-HSA-75158 5.835876e-01 0.234 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 5.835876e-01 0.234 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.835876e-01 0.234 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.835876e-01 0.234 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 5.835876e-01 0.234 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.835876e-01 0.234 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 5.835876e-01 0.234 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 5.835876e-01 0.234 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.835876e-01 0.234 0 0
Generation of second messenger molecules R-HSA-202433 5.849722e-01 0.233 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 5.861514e-01 0.232 0 0
Removal of the Flap Intermediate R-HSA-69166 5.861514e-01 0.232 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 5.861514e-01 0.232 0 0
Zinc transporters R-HSA-435354 5.861514e-01 0.232 0 0
Platelet degranulation R-HSA-114608 5.898300e-01 0.229 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 5.915299e-01 0.228 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 5.915299e-01 0.228 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 5.915299e-01 0.228 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 5.915299e-01 0.228 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 5.924774e-01 0.227 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 5.974688e-01 0.224 0 0
Inwardly rectifying K+ channels R-HSA-1296065 5.974688e-01 0.224 0 0
Protein localization R-HSA-9609507 5.980761e-01 0.223 0 0
ABC transporter disorders R-HSA-5619084 5.981755e-01 0.223 0 0
Extension of Telomeres R-HSA-180786 5.993628e-01 0.222 0 0
Amino acid transport across the plasma membrane R-HSA-352230 5.993628e-01 0.222 0 0
Platelet activation, signaling and aggregation R-HSA-76002 6.079401e-01 0.216 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 6.150770e-01 0.211 0 0
Syndecan interactions R-HSA-3000170 6.150770e-01 0.211 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 6.154252e-01 0.211 0 0
Erythropoietin activates RAS R-HSA-9027284 6.154252e-01 0.211 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.154252e-01 0.211 0 0
Formation of the anterior neural plate R-HSA-9823739 6.154252e-01 0.211 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 6.154252e-01 0.211 0 0
FGFR1 mutant receptor activation R-HSA-1839124 6.176754e-01 0.209 0 0
Intra-Golgi traffic R-HSA-6811438 6.213429e-01 0.207 0 0
Translation of Structural Proteins R-HSA-9683701 6.213429e-01 0.207 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.227890e-01 0.206 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 6.245546e-01 0.204 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 6.267922e-01 0.203 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.267922e-01 0.203 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 6.267922e-01 0.203 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 6.267922e-01 0.203 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.267922e-01 0.203 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 6.267922e-01 0.203 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 6.267922e-01 0.203 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.267922e-01 0.203 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.267922e-01 0.203 0 0
Abacavir transmembrane transport R-HSA-2161517 6.267922e-01 0.203 0 0
HDL clearance R-HSA-8964011 6.267922e-01 0.203 0 0
CREB3 factors activate genes R-HSA-8874211 6.267922e-01 0.203 0 0
Reproduction R-HSA-1474165 6.318702e-01 0.199 0 0
HCMV Late Events R-HSA-9610379 6.362903e-01 0.196 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 6.372346e-01 0.196 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 6.372346e-01 0.196 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 6.387973e-01 0.195 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 6.430820e-01 0.192 0 0
Activation of SMO R-HSA-5635838 6.430820e-01 0.192 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 6.430820e-01 0.192 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.430820e-01 0.192 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.430820e-01 0.192 0 0
Post-translational protein phosphorylation R-HSA-8957275 6.464690e-01 0.189 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 6.476261e-01 0.189 0 0
TBC/RABGAPs R-HSA-8854214 6.557443e-01 0.183 0 0
Signaling by SCF-KIT R-HSA-1433557 6.557443e-01 0.183 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 6.560769e-01 0.183 0 0
Tight junction interactions R-HSA-420029 6.593540e-01 0.181 0 0
Antigen processing-Cross presentation R-HSA-1236975 6.614762e-01 0.179 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.655163e-01 0.177 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.655163e-01 0.177 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 6.655163e-01 0.177 0 0
PTK6 Expression R-HSA-8849473 6.655163e-01 0.177 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.655163e-01 0.177 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.655163e-01 0.177 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 6.655163e-01 0.177 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.655163e-01 0.177 0 0
CHL1 interactions R-HSA-447041 6.655163e-01 0.177 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.655163e-01 0.177 0 0
Maturation of replicase proteins R-HSA-9694301 6.655163e-01 0.177 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 6.691423e-01 0.174 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.691423e-01 0.174 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.691423e-01 0.174 0 0
Passive transport by Aquaporins R-HSA-432047 6.691423e-01 0.174 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 6.691423e-01 0.174 0 0
Proteasome assembly R-HSA-9907900 6.721726e-01 0.173 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 6.727897e-01 0.172 0 0
Signaling by FGFR in disease R-HSA-1226099 6.740653e-01 0.171 0 0
Interleukin-1 family signaling R-HSA-446652 6.782355e-01 0.169 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 6.800660e-01 0.167 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 6.800660e-01 0.167 0 0
Co-inhibition by PD-1 R-HSA-389948 6.858685e-01 0.164 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 6.880742e-01 0.162 0 0
PRC2 methylates histones and DNA R-HSA-212300 6.918938e-01 0.160 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.936395e-01 0.159 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.936395e-01 0.159 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.936395e-01 0.159 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.936395e-01 0.159 0 0
Sulfide oxidation to sulfate R-HSA-1614517 6.936395e-01 0.159 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.936395e-01 0.159 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.936395e-01 0.159 0 0
Specification of primordial germ cells R-HSA-9827857 6.936395e-01 0.159 0 0
Signaling by FGFR3 in disease R-HSA-5655332 6.998270e-01 0.155 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 6.998270e-01 0.155 0 0
Insulin processing R-HSA-264876 6.998270e-01 0.155 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 7.002245e-01 0.155 0 0
Type I hemidesmosome assembly R-HSA-446107 7.002245e-01 0.155 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 7.002245e-01 0.155 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 7.002245e-01 0.155 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.002245e-01 0.155 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.002245e-01 0.155 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.002245e-01 0.155 0 0
Activation of RAS in B cells R-HSA-1169092 7.002245e-01 0.155 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.002245e-01 0.155 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 7.002245e-01 0.155 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 7.002245e-01 0.155 0 0
Adrenoceptors R-HSA-390696 7.002245e-01 0.155 0 0
Generic Transcription Pathway R-HSA-212436 7.023264e-01 0.153 1 0
mRNA Splicing - Minor Pathway R-HSA-72165 7.034433e-01 0.153 0 0
Signaling by TGFBR3 R-HSA-9839373 7.034433e-01 0.153 0 0
SLC-mediated transport of amino acids R-HSA-9958863 7.123322e-01 0.147 0 0
Synaptic adhesion-like molecules R-HSA-8849932 7.166174e-01 0.145 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 7.166174e-01 0.145 0 0
Platelet sensitization by LDL R-HSA-432142 7.166174e-01 0.145 0 0
Mismatch Repair R-HSA-5358508 7.166174e-01 0.145 0 0
Apoptotic factor-mediated response R-HSA-111471 7.166174e-01 0.145 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 7.182771e-01 0.144 0 0
Inflammasomes R-HSA-622312 7.186451e-01 0.143 0 0
MET promotes cell motility R-HSA-8875878 7.249262e-01 0.140 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.296231e-01 0.137 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 7.313329e-01 0.136 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.313329e-01 0.136 0 0
Calcineurin activates NFAT R-HSA-2025928 7.313329e-01 0.136 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.313329e-01 0.136 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.313329e-01 0.136 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.313329e-01 0.136 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.313329e-01 0.136 0 0
mRNA Editing R-HSA-75072 7.313329e-01 0.136 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 7.313329e-01 0.136 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.313329e-01 0.136 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 7.313329e-01 0.136 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.313329e-01 0.136 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.313329e-01 0.136 0 0
Interleukin-1 processing R-HSA-448706 7.313329e-01 0.136 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 7.333791e-01 0.135 0 0
mRNA Capping R-HSA-72086 7.365330e-01 0.133 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 7.365330e-01 0.133 0 0
Diseases of hemostasis R-HSA-9671793 7.381274e-01 0.132 0 0
STING mediated induction of host immune responses R-HSA-1834941 7.381274e-01 0.132 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 7.404224e-01 0.131 0 0
Pentose phosphate pathway R-HSA-71336 7.404224e-01 0.131 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.404224e-01 0.131 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.457591e-01 0.127 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 7.535082e-01 0.123 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 7.535082e-01 0.123 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.535082e-01 0.123 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 7.582268e-01 0.120 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 7.582268e-01 0.120 0 0
PI3K/AKT activation R-HSA-198203 7.592148e-01 0.120 0 0
Binding and entry of HIV virion R-HSA-173107 7.592148e-01 0.120 0 0
MAPK3 (ERK1) activation R-HSA-110056 7.592148e-01 0.120 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.592148e-01 0.120 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.592148e-01 0.120 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.592148e-01 0.120 0 0
Interleukin-27 signaling R-HSA-9020956 7.592148e-01 0.120 0 0
Maturation of spike protein R-HSA-9683686 7.592148e-01 0.120 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.592148e-01 0.120 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 7.600325e-01 0.119 0 0
Aquaporin-mediated transport R-HSA-445717 7.650385e-01 0.116 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.769765e-01 0.110 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 7.769765e-01 0.110 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.769765e-01 0.110 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 7.816266e-01 0.107 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.829199e-01 0.106 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 7.829199e-01 0.106 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.842046e-01 0.106 0 0
vRNA Synthesis R-HSA-192814 7.842046e-01 0.106 0 0
Propionyl-CoA catabolism R-HSA-71032 7.842046e-01 0.106 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.842046e-01 0.106 0 0
Synthesis of PI R-HSA-1483226 7.842046e-01 0.106 0 0
Bicarbonate transporters R-HSA-425381 7.842046e-01 0.106 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 7.842046e-01 0.106 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 7.842046e-01 0.106 0 0
PECAM1 interactions R-HSA-210990 7.842046e-01 0.106 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.842046e-01 0.106 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.842046e-01 0.106 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 7.848067e-01 0.105 0 0
Developmental Cell Lineages R-HSA-9734767 7.890472e-01 0.103 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.944402e-01 0.100 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 7.944402e-01 0.100 0 0
Activation of GABAB receptors R-HSA-991365 7.957934e-01 0.099 0 0
GABA B receptor activation R-HSA-977444 7.957934e-01 0.099 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 7.991802e-01 0.097 0 0
DS-GAG biosynthesis R-HSA-2022923 8.066022e-01 0.093 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 8.066022e-01 0.093 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 8.066022e-01 0.093 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.066022e-01 0.093 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.066022e-01 0.093 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.066022e-01 0.093 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.066022e-01 0.093 0 0
Sodium/Calcium exchangers R-HSA-425561 8.066022e-01 0.093 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.071415e-01 0.093 0 0
Disorders of transmembrane transporters R-HSA-5619115 8.096437e-01 0.092 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 8.106827e-01 0.091 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 8.106827e-01 0.091 0 0
LDL clearance R-HSA-8964038 8.106827e-01 0.091 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.127402e-01 0.090 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.127402e-01 0.090 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.127402e-01 0.090 0 0
Cardiac conduction R-HSA-5576891 8.142306e-01 0.089 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 8.189409e-01 0.087 0 0
Amine ligand-binding receptors R-HSA-375280 8.196893e-01 0.086 0 0
tRNA processing R-HSA-72306 8.220765e-01 0.085 0 0
eNOS activation R-HSA-203615 8.255161e-01 0.083 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 8.255161e-01 0.083 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.257694e-01 0.083 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.257694e-01 0.083 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 8.257694e-01 0.083 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 8.257694e-01 0.083 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.266763e-01 0.083 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.266763e-01 0.083 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.266763e-01 0.083 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.266763e-01 0.083 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 8.266763e-01 0.083 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.266763e-01 0.083 0 0
Synthesis of GDP-mannose R-HSA-446205 8.266763e-01 0.083 0 0
Polymerase switching R-HSA-69091 8.266763e-01 0.083 0 0
Leading Strand Synthesis R-HSA-69109 8.266763e-01 0.083 0 0
OAS antiviral response R-HSA-8983711 8.266763e-01 0.083 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.266763e-01 0.083 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.266763e-01 0.083 0 0
Interleukin-35 Signalling R-HSA-8984722 8.266763e-01 0.083 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.281030e-01 0.082 0 0
Somitogenesis R-HSA-9824272 8.307453e-01 0.081 0 0
Telomere Maintenance R-HSA-157579 8.340003e-01 0.079 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.375386e-01 0.077 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.375386e-01 0.077 0 0
PERK regulates gene expression R-HSA-381042 8.375386e-01 0.077 0 0
Synthesis of PA R-HSA-1483166 8.379090e-01 0.077 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 8.397652e-01 0.076 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.397652e-01 0.076 0 0
Mitochondrial RNA degradation R-HSA-9836573 8.397652e-01 0.076 0 0
Regulation of insulin secretion R-HSA-422356 8.414681e-01 0.075 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 8.427695e-01 0.074 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.446678e-01 0.073 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.446678e-01 0.073 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.446678e-01 0.073 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 8.446678e-01 0.073 0 0
Interleukin-6 signaling R-HSA-1059683 8.446678e-01 0.073 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.446678e-01 0.073 0 0
Base Excision Repair R-HSA-73884 8.468986e-01 0.072 0 0
Rab regulation of trafficking R-HSA-9007101 8.469699e-01 0.072 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.471808e-01 0.072 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 8.527339e-01 0.069 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.527339e-01 0.069 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.527339e-01 0.069 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.527339e-01 0.069 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 8.539974e-01 0.069 0 0
Peroxisomal protein import R-HSA-9033241 8.560091e-01 0.068 0 0
SLC transporter disorders R-HSA-5619102 8.576746e-01 0.067 0 0
NCAM1 interactions R-HSA-419037 8.594485e-01 0.066 0 0
GPER1 signaling R-HSA-9634597 8.605664e-01 0.065 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.607927e-01 0.065 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 8.607927e-01 0.065 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.607927e-01 0.065 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.607927e-01 0.065 0 0
Hydrolysis of LPC R-HSA-1483115 8.607927e-01 0.065 0 0
Physiological factors R-HSA-5578768 8.607927e-01 0.065 0 0
Malate-aspartate shuttle R-HSA-9856872 8.607927e-01 0.065 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.607927e-01 0.065 0 0
Ciprofloxacin ADME R-HSA-9793528 8.607927e-01 0.065 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.607927e-01 0.065 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.607927e-01 0.065 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.644076e-01 0.063 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.647380e-01 0.063 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.647380e-01 0.063 0 0
TRP channels R-HSA-3295583 8.647380e-01 0.063 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 8.647380e-01 0.063 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 8.682213e-01 0.061 0 0
Ion channel transport R-HSA-983712 8.693053e-01 0.061 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.693990e-01 0.061 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.752445e-01 0.058 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 8.752445e-01 0.058 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.752445e-01 0.058 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.752445e-01 0.058 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.752445e-01 0.058 0 0
p38MAPK events R-HSA-171007 8.752445e-01 0.058 0 0
DNA Damage Reversal R-HSA-73942 8.752445e-01 0.058 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 8.752445e-01 0.058 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.752445e-01 0.058 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.752445e-01 0.058 0 0
Protein methylation R-HSA-8876725 8.752445e-01 0.058 0 0
Packaging Of Telomere Ends R-HSA-171306 8.758378e-01 0.058 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 8.758378e-01 0.058 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.758378e-01 0.058 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.778529e-01 0.057 0 0
Neddylation R-HSA-8951664 8.785831e-01 0.056 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.787219e-01 0.056 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 8.799705e-01 0.056 0 0
Meiotic recombination R-HSA-912446 8.857775e-01 0.053 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.860917e-01 0.053 0 0
Pyrimidine salvage R-HSA-73614 8.860917e-01 0.053 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.874484e-01 0.052 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 8.874484e-01 0.052 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.874484e-01 0.052 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 8.874484e-01 0.052 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.881968e-01 0.051 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.881968e-01 0.051 0 0
Killing mechanisms R-HSA-9664420 8.881968e-01 0.051 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 8.881968e-01 0.051 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.881968e-01 0.051 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 8.881968e-01 0.051 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.881968e-01 0.051 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.881968e-01 0.051 0 0
Atorvastatin ADME R-HSA-9754706 8.881968e-01 0.051 0 0
Virus Assembly and Release R-HSA-168268 8.881968e-01 0.051 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.901112e-01 0.051 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 8.932498e-01 0.049 0 0
Insulin receptor signalling cascade R-HSA-74751 8.939826e-01 0.049 0 0
DNA methylation R-HSA-5334118 8.955556e-01 0.048 0 0
Platelet calcium homeostasis R-HSA-418360 8.955556e-01 0.048 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 8.955556e-01 0.048 0 0
DARPP-32 events R-HSA-180024 8.955556e-01 0.048 0 0
Regulation of gene expression in beta cells R-HSA-210745 8.955556e-01 0.048 0 0
Interferon alpha/beta signaling R-HSA-909733 8.972406e-01 0.047 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 8.998050e-01 0.046 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 8.998050e-01 0.046 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 8.998050e-01 0.046 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 8.998050e-01 0.046 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 8.998050e-01 0.046 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 8.998050e-01 0.046 0 0
Response to metal ions R-HSA-5660526 8.998050e-01 0.046 0 0
Hemostasis R-HSA-109582 9.001904e-01 0.046 0 0
PPARA activates gene expression R-HSA-1989781 9.005624e-01 0.045 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.022707e-01 0.045 0 0
Translation of Structural Proteins R-HSA-9694635 9.022707e-01 0.045 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.032332e-01 0.044 0 0
HIV Transcription Initiation R-HSA-167161 9.032332e-01 0.044 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.032332e-01 0.044 0 0
DAP12 signaling R-HSA-2424491 9.042831e-01 0.044 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.042831e-01 0.044 0 0
Neurotransmitter clearance R-HSA-112311 9.042831e-01 0.044 0 0
Interleukin-37 signaling R-HSA-9008059 9.042831e-01 0.044 0 0
Stimuli-sensing channels R-HSA-2672351 9.072151e-01 0.042 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.086914e-01 0.042 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.102086e-01 0.041 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.102086e-01 0.041 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 9.102086e-01 0.041 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.102086e-01 0.041 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.102086e-01 0.041 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.102086e-01 0.041 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 9.103506e-01 0.041 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.103506e-01 0.041 0 0
Depyrimidination R-HSA-73928 9.103506e-01 0.041 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.123249e-01 0.040 0 0
Cargo concentration in the ER R-HSA-5694530 9.123249e-01 0.040 0 0
Kidney development R-HSA-9830369 9.123426e-01 0.040 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.169893e-01 0.038 0 0
Defective pyroptosis R-HSA-9710421 9.169893e-01 0.038 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.191867e-01 0.037 0 0
Tie2 Signaling R-HSA-210993 9.195325e-01 0.036 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.197293e-01 0.036 0 0
Leishmania phagocytosis R-HSA-9664417 9.228251e-01 0.035 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.228251e-01 0.035 0 0
Parasite infection R-HSA-9664407 9.228251e-01 0.035 0 0
Amyloid fiber formation R-HSA-977225 9.231489e-01 0.035 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.233041e-01 0.035 0 0
Cardiogenesis R-HSA-9733709 9.265420e-01 0.033 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.278887e-01 0.033 0 0
Germ layer formation at gastrulation R-HSA-9754189 9.278887e-01 0.033 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.278887e-01 0.033 0 0
Specification of the neural plate border R-HSA-9834899 9.278887e-01 0.033 0 0
E2F mediated regulation of DNA replication R-HSA-113510 9.278887e-01 0.033 0 0
Maturation of nucleoprotein R-HSA-9694631 9.278887e-01 0.033 0 0
Other interleukin signaling R-HSA-449836 9.278887e-01 0.033 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.278887e-01 0.033 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.286252e-01 0.032 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.286252e-01 0.032 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.289388e-01 0.032 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.296926e-01 0.032 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.320390e-01 0.031 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.328060e-01 0.030 0 0
Heme degradation R-HSA-189483 9.328060e-01 0.030 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.343011e-01 0.030 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.343011e-01 0.030 0 0
Regulation of beta-cell development R-HSA-186712 9.345128e-01 0.029 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.353776e-01 0.029 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.353776e-01 0.029 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.353776e-01 0.029 0 0
Co-inhibition by CTLA4 R-HSA-389513 9.353776e-01 0.029 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.353776e-01 0.029 0 0
GABA receptor activation R-HSA-977443 9.390502e-01 0.027 0 0
Metabolism of polyamines R-HSA-351202 9.390502e-01 0.027 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.392233e-01 0.027 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.420892e-01 0.026 0 0
Signalling to RAS R-HSA-167044 9.420892e-01 0.026 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 9.420892e-01 0.026 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.420892e-01 0.026 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.420892e-01 0.026 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.420892e-01 0.026 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.420892e-01 0.026 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.420892e-01 0.026 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.432996e-01 0.025 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.432996e-01 0.025 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 9.436695e-01 0.025 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.438471e-01 0.025 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.438471e-01 0.025 0 0
Co-stimulation by CD28 R-HSA-389356 9.439221e-01 0.025 0 0
Gluconeogenesis R-HSA-70263 9.439221e-01 0.025 0 0
Platelet homeostasis R-HSA-418346 9.442816e-01 0.025 0 0
G alpha (q) signalling events R-HSA-416476 9.456378e-01 0.024 0 0
CS-GAG biosynthesis R-HSA-2022870 9.481040e-01 0.023 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.481040e-01 0.023 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.481040e-01 0.023 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.481040e-01 0.023 0 0
Serine metabolism R-HSA-977347 9.481040e-01 0.023 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.486978e-01 0.023 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 9.510882e-01 0.022 0 0
Voltage gated Potassium channels R-HSA-1296072 9.531470e-01 0.021 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.531470e-01 0.021 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.531470e-01 0.021 0 0
Cleavage of the damaged purine R-HSA-110331 9.531470e-01 0.021 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 9.534945e-01 0.021 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.534945e-01 0.021 0 0
Notch-HLH transcription pathway R-HSA-350054 9.534945e-01 0.021 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.534945e-01 0.021 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.534945e-01 0.021 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.534945e-01 0.021 0 0
Signaling by KIT in disease R-HSA-9669938 9.534945e-01 0.021 0 0
IGF1R signaling cascade R-HSA-2428924 9.544740e-01 0.020 0 0
FOXO-mediated transcription R-HSA-9614085 9.557786e-01 0.020 0 0
Depurination R-HSA-73927 9.572258e-01 0.019 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.572258e-01 0.019 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.572258e-01 0.019 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.577225e-01 0.019 0 0
Immune System R-HSA-168256 9.582103e-01 0.019 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.583253e-01 0.018 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.583253e-01 0.018 0 0
Carnitine shuttle R-HSA-200425 9.583253e-01 0.018 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.586647e-01 0.018 0 0
Signaling by ALK R-HSA-201556 9.609631e-01 0.017 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.626546e-01 0.017 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.626546e-01 0.017 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.626546e-01 0.017 0 0
Interleukin-6 family signaling R-HSA-6783589 9.626546e-01 0.017 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.631152e-01 0.016 0 0
PI Metabolism R-HSA-1483255 9.632813e-01 0.016 0 0
Infectious disease R-HSA-5663205 9.636935e-01 0.016 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.643859e-01 0.016 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.654891e-01 0.015 0 0
Signaling by Insulin receptor R-HSA-74752 9.664613e-01 0.015 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.665343e-01 0.015 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.665343e-01 0.015 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.665343e-01 0.015 0 0
Hyaluronan degradation R-HSA-2160916 9.665343e-01 0.015 0 0
Formation of the nephric duct R-HSA-9830364 9.665343e-01 0.015 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.665343e-01 0.015 0 0
Interleukin-7 signaling R-HSA-1266695 9.665343e-01 0.015 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.675190e-01 0.014 0 0
Paracetamol ADME R-HSA-9753281 9.682161e-01 0.014 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.700112e-01 0.013 0 0
Urea cycle R-HSA-70635 9.700112e-01 0.013 0 0
Sphingolipid catabolism R-HSA-9845614 9.700112e-01 0.013 0 0
Abacavir ADME R-HSA-2161522 9.700112e-01 0.013 0 0
Adaptive Immune System R-HSA-1280218 9.703776e-01 0.013 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.703858e-01 0.013 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.703858e-01 0.013 0 0
Heme biosynthesis R-HSA-189451 9.703858e-01 0.013 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.709782e-01 0.013 0 0
IRS-mediated signalling R-HSA-112399 9.730705e-01 0.012 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.731271e-01 0.012 0 0
Triglyceride biosynthesis R-HSA-75109 9.731271e-01 0.012 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 9.731271e-01 0.012 0 0
Synthesis of PE R-HSA-1483213 9.731271e-01 0.012 0 0
Signaling by BMP R-HSA-201451 9.731271e-01 0.012 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.731271e-01 0.012 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.759194e-01 0.011 0 0
Insulin receptor recycling R-HSA-77387 9.759194e-01 0.011 0 0
Potassium Channels R-HSA-1296071 9.760399e-01 0.011 0 0
DAP12 interactions R-HSA-2172127 9.775953e-01 0.010 0 0
Surfactant metabolism R-HSA-5683826 9.775953e-01 0.010 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.784217e-01 0.009 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.795963e-01 0.009 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.814235e-01 0.008 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.826736e-01 0.008 0 0
Parasitic Infection Pathways R-HSA-9824443 9.829581e-01 0.007 0 0
Leishmania infection R-HSA-9658195 9.829581e-01 0.007 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.834026e-01 0.007 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.845862e-01 0.007 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.854266e-01 0.006 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.854266e-01 0.006 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.854266e-01 0.006 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.860019e-01 0.006 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.860880e-01 0.006 0 0
Recycling of bile acids and salts R-HSA-159418 9.860880e-01 0.006 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 9.871950e-01 0.006 0 0
Activation of HOX genes during differentiation R-HSA-5619507 9.871950e-01 0.006 0 0
PI3K Cascade R-HSA-109704 9.872681e-01 0.006 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.874364e-01 0.005 0 0
CS/DS degradation R-HSA-2024101 9.875341e-01 0.005 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.875341e-01 0.005 0 0
The phototransduction cascade R-HSA-2514856 9.884223e-01 0.005 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.888299e-01 0.005 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 9.888299e-01 0.005 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.888299e-01 0.005 0 0
Hyaluronan metabolism R-HSA-2142845 9.888299e-01 0.005 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.888299e-01 0.005 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.888299e-01 0.005 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.894743e-01 0.005 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.899911e-01 0.004 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.904327e-01 0.004 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.910316e-01 0.004 0 0
Triglyceride catabolism R-HSA-163560 9.910316e-01 0.004 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.910316e-01 0.004 0 0
COPII-mediated vesicle transport R-HSA-204005 9.911165e-01 0.004 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.914156e-01 0.004 0 0
ECM proteoglycans R-HSA-3000178 9.918592e-01 0.004 0 0
Metabolism of porphyrins R-HSA-189445 9.918592e-01 0.004 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.919641e-01 0.004 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.919641e-01 0.004 0 0
Collagen chain trimerization R-HSA-8948216 9.919641e-01 0.004 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.924308e-01 0.003 0 0
Disease R-HSA-1643685 9.931536e-01 0.003 0 0
Aspirin ADME R-HSA-9749641 9.931689e-01 0.003 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.935483e-01 0.003 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.940823e-01 0.003 0 0
Tryptophan catabolism R-HSA-71240 9.942192e-01 0.003 0 0
Interleukin-2 family signaling R-HSA-451927 9.942192e-01 0.003 0 0
Gastrulation R-HSA-9758941 9.942238e-01 0.003 0 0
Neurotransmitter release cycle R-HSA-112310 9.945504e-01 0.002 0 0
Triglyceride metabolism R-HSA-8979227 9.946275e-01 0.002 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.946275e-01 0.002 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.948203e-01 0.002 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.948203e-01 0.002 0 0
Maturation of spike protein R-HSA-9694548 9.948203e-01 0.002 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.951234e-01 0.002 0 0
Post-translational protein modification R-HSA-597592 9.951620e-01 0.002 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.955662e-01 0.002 0 0
Nucleotide salvage R-HSA-8956321 9.955742e-01 0.002 0 0
Integrin cell surface interactions R-HSA-216083 9.956125e-01 0.002 0 0
Cholesterol biosynthesis R-HSA-191273 9.956125e-01 0.002 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.958417e-01 0.002 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.964061e-01 0.002 0 0
Methylation R-HSA-156581 9.966618e-01 0.001 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.970090e-01 0.001 0 0
Metabolism of proteins R-HSA-392499 9.970203e-01 0.001 0 0
Synthesis of PC R-HSA-1483191 9.975990e-01 0.001 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 9.977659e-01 0.001 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.977874e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.983370e-01 0.001 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.984008e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.984529e-01 0.001 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.984529e-01 0.001 0 0
Peptide hormone metabolism R-HSA-2980736 9.986421e-01 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 9.987581e-01 0.001 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.988803e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.990032e-01 0.000 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.990630e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.991457e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.991527e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.992323e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.992975e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.993532e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.993558e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.994499e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.994536e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.994631e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.994846e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.995110e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.995434e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.995863e-01 0.000 0 0
Glycosphingolipid biosynthesis R-HSA-9840309 9.996294e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.996620e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.996638e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.996924e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.997336e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.997496e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.997613e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.997613e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.998264e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.998284e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.998463e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.998463e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.998479e-01 0.000 0 0
Collagen formation R-HSA-1474290 9.998637e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.998660e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.998767e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.998768e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.998860e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.998860e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999206e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999243e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999251e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.999289e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999479e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999607e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.999660e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999710e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999804e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999858e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999865e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999882e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999888e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.999894e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999921e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999935e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999969e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999971e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999980e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999991e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999992e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999997e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999997e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999997e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999999e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999999e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999999e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways