NIK

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
O14920 S177 PSP IKBKB IKKB EQRLIHKIIDLGYAKELDQGsLCTsFVGTLQyLAPELLEQQ
O14920 S181 PSP IKBKB IKKB IHKIIDLGYAKELDQGsLCTsFVGTLQyLAPELLEQQKyTV
O15111 S176 SIGNOR|iPTMNet|PSP CHUK IKKA TCF16 GGKIIHKIIDLGYAKDVDQGsLCTsFVGTLQYLAPELFENK
O15111 S180 SIGNOR|iPTMNet|PSP CHUK IKKA TCF16 IHKIIDLGYAKDVDQGsLCTsFVGTLQYLAPELFENKPYTA
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P07900 S165 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGTK
P07900 T171 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA ITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGTKVILHLK
P08238 S160 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB AEKVVVITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGTK
P08238 T166 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB ITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGTKVILHLK
P11413 S278 PSP G6PD DVMQNHLLQMLCLVAMEKPAsTNSDDVRDEKVKVLKCISEV
P11413 S40 SIGNOR|PSP G6PD LFQGDAFHQSDTHIFIIMGAsGDLAKKKIYPTIWWLFRDGL
P11413 S486 PSP G6PD tPLLHQIELEKPKPIPYIYGsRGPTEADELMKRVGFQyEGt
P11413 S8 PSP G6PD _____________MAEQVALsRtQVCGILREELFQGDAFHQ
P12277 T322 Sugiyama CKB CKBB LGKHEKFsEVLKRLRLQKRGtGGVDtAAVGGVFDVsNADRL
P12277 T327 Sugiyama CKB CKBB KFsEVLKRLRLQKRGtGGVDtAAVGGVFDVsNADRLGFSEV
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14618 S202 Sugiyama PKM OIP3 PK2 PK3 PKM2 SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs
P25963 S32 PSP NFKBIA IKBA MAD3 NFKBI AMEGPRDGLKKERLLDDRHDsGLDsMKDEEyEQMVKELQEI
P25963 S36 PSP NFKBIA IKBA MAD3 NFKBI PRDGLKKERLLDDRHDsGLDsMKDEEyEQMVKELQEIRLEP
P36578 S66 Sugiyama RPL4 RPL1 KNNRQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGGGtHR
P36578 T62 Sugiyama RPL4 RPL1 TNLRKNNRQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGG
P36578 T69 Sugiyama RPL4 RPL1 RQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGGGtHRsGQ
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P61160 T237 PSP ACTR2 ARP2 KEKLCYVGYNIEQEQKLALEttVLVESYTLPDGRIIKVGGE
P61160 T238 PSP ACTR2 ARP2 EKLCYVGYNIEQEQKLALEttVLVESYTLPDGRIIKVGGER
P61160 Y202 PSP ACTR2 ARP2 LDIAGRDITRYLIKLLLLRGyAFNHSADFETVRMIKEKLCY
P61254 T8 Sugiyama RPL26 _____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P67809 T108 Sugiyama YBX1 NSEP1 YB1 QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P67809 Y99 Sugiyama YBX1 NSEP1 YB1 DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
P68363 T73 Sugiyama TUBA1B FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363 Y83 Sugiyama TUBA1B PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q00653 S866 SIGNOR|ELM|iPTMNet|EPSD|PSP NFKB2 LYT10 LLRGPETRDKLPstAEVKEDsAyGsQsVEQEAEKLGPPPEP
Q00653 S870 SIGNOR|ELM|iPTMNet|EPSD|PSP NFKB2 LYT10 PETRDKLPstAEVKEDsAyGsQsVEQEAEKLGPPPEPPGGL
Q14568 S165 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGTK
Q14568 T171 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 ITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGTKVILHLK
Q71U36 T73 Sugiyama TUBA1A TUBA3 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36 Y83 Sugiyama TUBA1A TUBA3 PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q99558 S410 Sugiyama MAP3K14 NIK DYEYREEVHWATHQLRLGRGsFGEVHRMEDKQTGFQCAVKK
Q99558 S826 Sugiyama MAP3K14 NIK SDDSEKNPsKAsQSsRDTLSsGVHsWSSQAEARSSsWNMVL
Q99558 S830 Sugiyama MAP3K14 NIK EKNPsKAsQSsRDTLSsGVHsWSSQAEARSSsWNMVLARGR
Q99558 S841 Sugiyama MAP3K14 NIK RDTLSsGVHsWSSQAEARSSsWNMVLARGRPTDtPsyFNGV
Q99558 S856 Sugiyama MAP3K14 NIK EARSSsWNMVLARGRPTDtPsyFNGVKVQIQSLNGEHLHIR
Q99558 T685 Sugiyama MAP3K14 NIK WRGEYKEPRHPPPNQANyHQtLHAQPRELSPRAPGPRPAEE
Q99558 T854 Sugiyama MAP3K14 NIK QAEARSSsWNMVLARGRPTDtPsyFNGVKVQIQSLNGEHLH
Q99558 Y682 Sugiyama MAP3K14 NIK KSPWRGEYKEPRHPPPNQANyHQtLHAQPRELSPRAPGPRP
Q99558 Y857 Sugiyama MAP3K14 NIK ARSSsWNMVLARGRPTDtPsyFNGVKVQIQSLNGEHLHIRE
Q9BQE3 T73 Sugiyama TUBA1C TUBA6 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3 Y83 Sugiyama TUBA1C TUBA6 PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q9UNX3 T8 Sugiyama RPL26L1 RPL26P1 _____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Q9Y2T7 T143 Sugiyama YBX2 CSDA3 MSY2 QtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEATNVTGP
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 3.756464e-10 9.425 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 6.933116e-10 9.159 0 0
Signal Transduction R-HSA-162582 2.402168e-09 8.619 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 6.315107e-09 8.200 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 8.066488e-08 7.093 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.068730e-07 6.971 0 0
Apoptotic execution phase R-HSA-75153 2.480873e-07 6.605 0 0
Cell Cycle, Mitotic R-HSA-69278 3.782379e-07 6.422 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 9.317706e-07 6.031 0 0
Cell Cycle Checkpoints R-HSA-69620 1.104291e-06 5.957 0 0
Axon guidance R-HSA-422475 1.899883e-06 5.721 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.047325e-06 5.689 0 0
RNA Polymerase II Transcription R-HSA-73857 2.984372e-06 5.525 0 0
Metalloprotease DUBs R-HSA-5689901 4.637033e-06 5.334 0 0
Cellular Senescence R-HSA-2559583 4.846234e-06 5.315 0 0
Meiotic synapsis R-HSA-1221632 5.471152e-06 5.262 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 6.651918e-06 5.177 0 0
NRAGE signals death through JNK R-HSA-193648 9.569234e-06 5.019 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.212167e-05 4.916 0 0
Nervous system development R-HSA-9675108 1.327325e-05 4.877 0 0
Chromatin modifying enzymes R-HSA-3247509 1.375658e-05 4.861 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.918062e-05 4.717 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.918062e-05 4.717 0 0
Generic Transcription Pathway R-HSA-212436 1.819501e-05 4.740 0 0
G alpha (12/13) signalling events R-HSA-416482 2.186459e-05 4.660 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.786528e-05 4.555 0 0
Gene expression (Transcription) R-HSA-74160 3.302743e-05 4.481 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 3.803423e-05 4.420 0 0
Mitotic Prometaphase R-HSA-68877 3.954680e-05 4.403 0 0
Developmental Biology R-HSA-1266738 4.021257e-05 4.396 0 0
Chromatin organization R-HSA-4839726 4.240859e-05 4.373 0 0
HATs acetylate histones R-HSA-3214847 4.509254e-05 4.346 0 0
Mitotic Spindle Checkpoint R-HSA-69618 5.073292e-05 4.295 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.425080e-05 4.266 0 0
Meiosis R-HSA-1500620 5.671713e-05 4.246 0 0
RET signaling R-HSA-8853659 6.702386e-05 4.174 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 8.788154e-05 4.056 0 0
ESR-mediated signaling R-HSA-8939211 9.220542e-05 4.035 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 9.990635e-05 4.000 0 0
M Phase R-HSA-68886 1.020859e-04 3.991 0 0
Rap1 signalling R-HSA-392517 1.119306e-04 3.951 0 0
HDACs deacetylate histones R-HSA-3214815 1.292433e-04 3.889 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.522056e-04 3.818 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.731607e-04 3.762 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 2.221580e-04 3.653 0 0
Reproduction R-HSA-1474165 2.281056e-04 3.642 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.479911e-04 3.606 0 0
Intracellular signaling by second messengers R-HSA-9006925 3.196812e-04 3.495 0 0
FOXO-mediated transcription R-HSA-9614085 3.950267e-04 3.403 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 3.950267e-04 3.403 0 0
Muscle contraction R-HSA-397014 3.996344e-04 3.398 0 0
MAPK family signaling cascades R-HSA-5683057 4.146291e-04 3.382 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 4.261545e-04 3.370 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.891716e-04 3.311 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.891716e-04 3.311 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 4.891716e-04 3.311 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 5.169570e-04 3.287 0 0
Regulation of TP53 Activity R-HSA-5633007 5.186092e-04 3.285 0 0
G2/M DNA damage checkpoint R-HSA-69473 4.837859e-04 3.315 0 0
Mitotic Anaphase R-HSA-68882 5.185077e-04 3.285 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 5.209147e-04 3.283 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 4.688553e-04 3.329 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 5.538701e-04 3.257 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 5.538701e-04 3.257 0 0
mRNA Splicing - Major Pathway R-HSA-72163 5.373846e-04 3.270 0 0
Oncogenic MAPK signaling R-HSA-6802957 5.524045e-04 3.258 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 5.526946e-04 3.258 0 0
Sema4D in semaphorin signaling R-HSA-400685 6.069919e-04 3.217 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 6.202485e-04 3.207 0 0
Apoptosis R-HSA-109581 6.016824e-04 3.221 0 0
Separation of Sister Chromatids R-HSA-2467813 6.961099e-04 3.157 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 7.200188e-04 3.143 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 8.241387e-04 3.084 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 8.156097e-04 3.089 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 8.375395e-04 3.077 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 8.652078e-04 3.063 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 8.848334e-04 3.053 0 0
Packaging Of Telomere Ends R-HSA-171306 9.042373e-04 3.044 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 9.608679e-04 3.017 0 0
mRNA Splicing R-HSA-72172 1.094145e-03 2.961 0 0
Programmed Cell Death R-HSA-5357801 1.163526e-03 2.934 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.226016e-03 2.912 0 0
RMTs methylate histone arginines R-HSA-3214858 1.259135e-03 2.900 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.277917e-03 2.893 0 0
Semaphorin interactions R-HSA-373755 1.292802e-03 2.888 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.301547e-03 2.886 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 1.409295e-03 2.851 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.357587e-03 2.867 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.414047e-03 2.850 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.394609e-03 2.856 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.432566e-03 2.844 0 0
Cleavage of the damaged purine R-HSA-110331 1.432566e-03 2.844 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.445244e-03 2.840 0 0
Cardiac conduction R-HSA-5576891 1.516670e-03 2.819 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.656259e-03 2.781 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.656259e-03 2.781 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.656259e-03 2.781 0 0
Signaling by RAS mutants R-HSA-6802949 1.656259e-03 2.781 0 0
Depurination R-HSA-73927 1.666210e-03 2.778 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.671351e-03 2.777 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.815779e-03 2.741 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.929437e-03 2.715 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.947369e-03 2.711 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.147550e-03 2.668 0 0
Signaling by Interleukins R-HSA-449147 2.022596e-03 2.694 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.155600e-03 2.666 0 0
Signaling by Hippo R-HSA-2028269 2.180397e-03 2.661 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.224846e-03 2.653 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 2.224846e-03 2.653 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.252523e-03 2.647 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.516356e-03 2.599 0 0
Integrin signaling R-HSA-354192 2.539658e-03 2.595 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.351403e-03 2.629 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.539658e-03 2.595 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.555149e-03 2.593 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.555149e-03 2.593 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.555149e-03 2.593 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 2.555149e-03 2.593 0 0
Signaling by NTRKs R-HSA-166520 2.576169e-03 2.589 0 0
Kinesins R-HSA-983189 2.812083e-03 2.551 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.665196e-03 2.574 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.722002e-03 2.565 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.812083e-03 2.551 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.903586e-03 2.537 0 0
MAP2K and MAPK activation R-HSA-5674135 2.923159e-03 2.534 0 0
Ub-specific processing proteases R-HSA-5689880 2.950354e-03 2.530 0 0
Meiotic recombination R-HSA-912446 3.103431e-03 2.508 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.137595e-03 2.503 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 3.214208e-03 2.493 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.383553e-03 2.471 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 3.425395e-03 2.465 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.479941e-03 2.458 0 0
mRNA 3'-end processing R-HSA-72187 3.487425e-03 2.457 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.851883e-03 2.414 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 3.860940e-03 2.413 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 4.054711e-03 2.392 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 4.218978e-03 2.375 0 0
Netrin-1 signaling R-HSA-373752 4.282992e-03 2.368 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 4.387421e-03 2.358 0 0
Regulation of TP53 Degradation R-HSA-6804757 4.533644e-03 2.344 0 0
Signaling by VEGF R-HSA-194138 4.807777e-03 2.318 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 4.831822e-03 2.316 0 0
Nucleosome assembly R-HSA-774815 4.831822e-03 2.316 0 0
DNA methylation R-HSA-5334118 5.277979e-03 2.278 0 0
DNA Double Strand Break Response R-HSA-5693606 5.752321e-03 2.240 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 5.181805e-03 2.286 0 0
TCF dependent signaling in response to WNT R-HSA-201681 5.265024e-03 2.279 0 0
Post NMDA receptor activation events R-HSA-438064 5.433876e-03 2.265 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 5.410215e-03 2.267 0 0
Diseases of programmed cell death R-HSA-9645723 5.901092e-03 2.229 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 6.007669e-03 2.221 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 6.022775e-03 2.220 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 6.022775e-03 2.220 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 6.117754e-03 2.213 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 6.688101e-03 2.175 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 6.915728e-03 2.160 0 0
Cell junction organization R-HSA-446728 7.059491e-03 2.151 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 7.098013e-03 2.149 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 7.369306e-03 2.133 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 7.809559e-03 2.107 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 7.825219e-03 2.107 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.090917e-03 2.092 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 8.896292e-03 2.051 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 8.289116e-03 2.081 0 0
Signaling by ERBB2 R-HSA-1227986 8.090899e-03 2.092 0 0
Diseases of mitotic cell cycle R-HSA-9675126 8.090917e-03 2.092 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 8.637323e-03 2.064 0 0
Deubiquitination R-HSA-5688426 8.174895e-03 2.088 0 0
Adherens junctions interactions R-HSA-418990 9.028323e-03 2.044 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 9.041617e-03 2.044 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 9.494514e-03 2.023 0 0
Signaling by RAF1 mutants R-HSA-9656223 9.539686e-03 2.020 0 0
Response of endothelial cells to shear stress R-HSA-9860931 9.683394e-03 2.014 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.003550e-02 1.998 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.066619e-02 1.972 0 0
Depyrimidination R-HSA-73928 1.066619e-02 1.972 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.263602e-02 1.898 0 0
RAF activation R-HSA-5673000 1.187789e-02 1.925 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.141633e-02 1.942 0 0
IGF1R signaling cascade R-HSA-2428924 1.168349e-02 1.932 0 0
Developmental Cell Lineages R-HSA-9734767 1.151147e-02 1.939 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.229019e-02 1.910 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.229019e-02 1.910 0 0
Polo-like kinase mediated events R-HSA-156711 1.249869e-02 1.903 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.249944e-02 1.903 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.263602e-02 1.898 0 0
G2/M Transition R-HSA-69275 1.189447e-02 1.925 0 0
Cell-cell junction organization R-HSA-421270 1.217085e-02 1.915 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.250056e-02 1.903 0 0
L1CAM interactions R-HSA-373760 1.188494e-02 1.925 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.256484e-02 1.901 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 1.274537e-02 1.895 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.274537e-02 1.895 0 0
Oncogene Induced Senescence R-HSA-2559585 1.338525e-02 1.873 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 1.389209e-02 1.857 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.454893e-02 1.837 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.463646e-02 1.835 0 0
Specification of the neural plate border R-HSA-9834899 1.475102e-02 1.831 0 0
Germ layer formation at gastrulation R-HSA-9754189 1.475102e-02 1.831 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.475102e-02 1.831 0 0
Calmodulin induced events R-HSA-111933 1.502503e-02 1.823 0 0
CaM pathway R-HSA-111997 1.502503e-02 1.823 0 0
Ion homeostasis R-HSA-5578775 1.511668e-02 1.821 0 0
Mitotic Prophase R-HSA-68875 1.518443e-02 1.819 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.559261e-02 1.807 0 0
Death Receptor Signaling R-HSA-73887 1.559261e-02 1.807 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.563107e-02 1.806 0 0
Signaling by LTK R-HSA-9842663 1.563107e-02 1.806 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.676376e-02 1.776 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.617147e-02 1.791 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 1.680293e-02 1.775 0 0
Recycling pathway of L1 R-HSA-437239 1.781940e-02 1.749 0 0
Signaling by TGFBR3 R-HSA-9839373 1.617147e-02 1.791 0 0
Formation of definitive endoderm R-HSA-9823730 1.726009e-02 1.763 0 0
Cell-Cell communication R-HSA-1500931 1.835226e-02 1.736 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.746765e-02 1.758 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.746765e-02 1.758 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.677130e-02 1.775 1 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.868941e-02 1.728 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.903768e-02 1.720 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.903768e-02 1.720 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 1.903768e-02 1.720 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.903768e-02 1.720 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.903768e-02 1.720 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.917372e-02 1.717 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.917372e-02 1.717 0 0
GPER1 signaling R-HSA-9634597 1.958441e-02 1.708 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.960172e-02 1.708 0 0
EPH-Ephrin signaling R-HSA-2682334 1.998604e-02 1.699 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 2.003657e-02 1.698 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 2.070193e-02 1.684 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.122433e-02 1.673 0 0
Activation of BH3-only proteins R-HSA-114452 2.122433e-02 1.673 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.203227e-02 1.657 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.203227e-02 1.657 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.249776e-02 1.648 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.249776e-02 1.648 0 0
Regulation of TP53 Expression R-HSA-6804754 2.376356e-02 1.624 0 0
Potassium transport channels R-HSA-1296067 2.376356e-02 1.624 0 0
G2/M Checkpoints R-HSA-69481 2.385781e-02 1.622 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.402161e-02 1.619 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.402161e-02 1.619 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.430242e-02 1.614 0 0
FGFR1b ligand binding and activation R-HSA-190370 2.810047e-02 1.551 0 0
Centrosome maturation R-HSA-380287 2.770876e-02 1.557 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.777946e-02 1.556 0 0
Telomere Maintenance R-HSA-157579 2.916280e-02 1.535 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.804988e-02 1.552 0 0
G0 and Early G1 R-HSA-1538133 2.667197e-02 1.574 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.843641e-02 1.546 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.745423e-02 1.561 0 0
mTORC1-mediated signalling R-HSA-166208 2.642929e-02 1.578 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 2.789341e-02 1.554 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.713879e-02 1.566 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.713879e-02 1.566 0 0
Interleukin-12 signaling R-HSA-9020591 2.969604e-02 1.527 0 0
Cardiogenesis R-HSA-9733709 2.971361e-02 1.527 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.971361e-02 1.527 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.971361e-02 1.527 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 3.006153e-02 1.522 0 0
Ca-dependent events R-HSA-111996 3.066434e-02 1.513 0 0
Chromosome Maintenance R-HSA-73886 3.228522e-02 1.491 0 0
Striated Muscle Contraction R-HSA-390522 3.297415e-02 1.482 0 0
Defective pyroptosis R-HSA-9710421 3.355054e-02 1.474 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.399314e-02 1.469 0 0
Neurodegenerative Diseases R-HSA-8863678 3.399314e-02 1.469 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 3.496368e-02 1.456 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 3.496368e-02 1.456 0 0
Cyclin D associated events in G1 R-HSA-69231 3.661203e-02 1.436 0 0
G1 Phase R-HSA-69236 3.661203e-02 1.436 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 3.701683e-02 1.432 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 3.701683e-02 1.432 0 0
HDMs demethylate histones R-HSA-3214842 3.822926e-02 1.418 0 0
Long-term potentiation R-HSA-9620244 3.822926e-02 1.418 0 0
Signaling by EGFR R-HSA-177929 3.836986e-02 1.416 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.937770e-02 1.405 0 0
DAG and IP3 signaling R-HSA-1489509 3.985209e-02 1.400 0 0
Signalling to ERKs R-HSA-187687 4.016961e-02 1.396 0 0
S Phase R-HSA-69242 4.077018e-02 1.390 0 0
Processing of DNA double-strand break ends R-HSA-5693607 4.115606e-02 1.386 0 0
Amyloid fiber formation R-HSA-977225 4.115606e-02 1.386 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 4.148748e-02 1.382 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 4.148748e-02 1.382 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 4.148748e-02 1.382 0 0
NADE modulates death signalling R-HSA-205025 4.953171e-02 1.305 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.953171e-02 1.305 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.953171e-02 1.305 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.953171e-02 1.305 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.953171e-02 1.305 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.260918e-02 1.370 0 0
ChREBP activates metabolic gene expression R-HSA-163765 5.101756e-02 1.292 0 0
PKA activation in glucagon signalling R-HSA-164378 4.870475e-02 1.312 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 4.762981e-02 1.322 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 4.376648e-02 1.359 0 0
Ephrin signaling R-HSA-3928664 4.870475e-02 1.312 0 0
Signal attenuation R-HSA-74749 4.260918e-02 1.370 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.953171e-02 1.305 0 0
Homology Directed Repair R-HSA-5693538 5.300645e-02 1.276 0 0
Dopamine receptors R-HSA-390651 4.953171e-02 1.305 0 0
PKA activation R-HSA-163615 4.870475e-02 1.312 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 4.748658e-02 1.323 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.931953e-02 1.307 0 0
TRP channels R-HSA-3295583 4.277388e-02 1.369 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 4.762981e-02 1.322 1 1
Apoptosis induced DNA fragmentation R-HSA-140342 4.260918e-02 1.370 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 4.870475e-02 1.312 0 0
NGF-stimulated transcription R-HSA-9031628 5.067145e-02 1.295 0 0
Co-stimulation by CD28 R-HSA-389356 5.067145e-02 1.295 1 0
Specification of primordial germ cells R-HSA-9827857 4.263414e-02 1.370 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 5.326902e-02 1.274 0 0
Signaling by ALK in cancer R-HSA-9700206 5.326902e-02 1.274 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 5.385146e-02 1.269 0 0
Immune System R-HSA-168256 5.412263e-02 1.267 1 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 5.465171e-02 1.262 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 5.465171e-02 1.262 0 0
PLC beta mediated events R-HSA-112043 5.479137e-02 1.261 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 5.522643e-02 1.258 0 0
Stimuli-sensing channels R-HSA-2672351 5.597781e-02 1.252 0 0
Epigenetic regulation of gene expression R-HSA-212165 5.613908e-02 1.251 0 0
HCMV Early Events R-HSA-9609690 5.633218e-02 1.249 0 0
Drug resistance of KIT mutants R-HSA-9669937 5.723190e-02 1.242 0 0
KIT mutants bind TKIs R-HSA-9669921 5.723190e-02 1.242 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 5.723190e-02 1.242 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 5.723190e-02 1.242 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 5.723190e-02 1.242 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 5.723190e-02 1.242 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 5.723190e-02 1.242 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 5.723190e-02 1.242 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 5.723190e-02 1.242 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 5.723190e-02 1.242 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 5.723190e-02 1.242 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 5.723190e-02 1.242 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 5.723254e-02 1.242 0 0
Signaling by ERBB4 R-HSA-1236394 5.723254e-02 1.242 0 0
Signaling by ALK R-HSA-201556 5.734802e-02 1.241 0 0
Cellular responses to stimuli R-HSA-8953897 5.750757e-02 1.240 0 0
DARPP-32 events R-HSA-180024 5.828131e-02 1.234 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.853997e-02 1.233 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 5.983582e-02 1.223 0 0
Signaling by GSK3beta mutants R-HSA-5339716 6.016374e-02 1.221 0 0
IRS activation R-HSA-74713 6.490841e-02 1.188 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 6.490841e-02 1.188 0 0
G2 Phase R-HSA-68911 6.490841e-02 1.188 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 6.490841e-02 1.188 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 7.001809e-02 1.155 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 7.001809e-02 1.155 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 7.001809e-02 1.155 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 7.001809e-02 1.155 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 7.001809e-02 1.155 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 7.001809e-02 1.155 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 7.001809e-02 1.155 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.054721e-02 1.094 0 0
Formation of axial mesoderm R-HSA-9796292 8.054721e-02 1.094 0 0
Co-inhibition by CTLA4 R-HSA-389513 6.219469e-02 1.206 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 6.960297e-02 1.157 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 7.744275e-02 1.111 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 7.744275e-02 1.111 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 7.744275e-02 1.111 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 7.832527e-02 1.106 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 6.773462e-02 1.169 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 7.247872e-02 1.140 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 6.244665e-02 1.204 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 6.244665e-02 1.204 0 0
AURKA Activation by TPX2 R-HSA-8854518 7.512315e-02 1.124 0 0
Nuclear Receptor transcription pathway R-HSA-383280 7.210675e-02 1.142 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 6.520300e-02 1.186 0 0
MHC class II antigen presentation R-HSA-2132295 6.658028e-02 1.177 0 0
Signaling by FGFR2 R-HSA-5654738 8.036349e-02 1.095 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 7.001809e-02 1.155 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 7.001809e-02 1.155 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 6.244665e-02 1.204 0 0
Repression of WNT target genes R-HSA-4641265 7.001809e-02 1.155 0 0
Signaling by WNT in cancer R-HSA-4791275 7.660027e-02 1.116 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.054721e-02 1.094 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 8.036349e-02 1.095 0 0
G-protein mediated events R-HSA-112040 7.966885e-02 1.099 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 8.054721e-02 1.094 0 0
RNA Polymerase I Transcription R-HSA-73864 7.210675e-02 1.142 0 0
Frs2-mediated activation R-HSA-170968 8.054721e-02 1.094 0 0
DNA Repair R-HSA-73894 6.911448e-02 1.160 0 0
Neuronal System R-HSA-112316 7.704949e-02 1.113 0 0
Signaling by WNT R-HSA-195721 6.284169e-02 1.202 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 7.744275e-02 1.111 0 0
MTOR signalling R-HSA-165159 7.832527e-02 1.106 0 0
Negative regulation of MAPK pathway R-HSA-5675221 7.272420e-02 1.138 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 8.054721e-02 1.094 0 0
Protein hydroxylation R-HSA-9629569 6.219469e-02 1.206 0 0
FLT3 Signaling R-HSA-9607240 6.736049e-02 1.172 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 6.439792e-02 1.191 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 7.744275e-02 1.111 0 0
NrCAM interactions R-HSA-447038 6.490841e-02 1.188 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 7.744275e-02 1.111 0 0
Signaling by NOTCH R-HSA-157118 6.181604e-02 1.209 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 7.090264e-02 1.149 0 0
Base Excision Repair R-HSA-73884 7.237843e-02 1.140 0 0
Interleukin-12 family signaling R-HSA-447115 6.179311e-02 1.209 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 8.163869e-02 1.088 0 0
Formation of lateral plate mesoderm R-HSA-9758920 8.163869e-02 1.088 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 8.163869e-02 1.088 0 0
Opioid Signalling R-HSA-111885 8.272829e-02 1.082 0 0
FGFR1 mutant receptor activation R-HSA-1839124 8.332182e-02 1.079 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 8.332182e-02 1.079 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 8.332182e-02 1.079 0 0
Signaling by FGFR4 R-HSA-5654743 8.416225e-02 1.075 0 0
Signaling by FGFR1 R-HSA-5654736 8.786000e-02 1.056 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 8.786000e-02 1.056 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 8.786000e-02 1.056 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 8.786000e-02 1.056 0 0
Cellular responses to stress R-HSA-2262752 8.973470e-02 1.047 0 0
EPHB-mediated forward signaling R-HSA-3928662 9.023315e-02 1.045 0 0
Regulation of KIT signaling R-HSA-1433559 9.171482e-02 1.038 0 0
HDL assembly R-HSA-8963896 9.171482e-02 1.038 0 0
Nuclear Envelope Breakdown R-HSA-2980766 9.336752e-02 1.030 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.426510e-02 1.026 0 0
Signaling by FGFR3 R-HSA-5654741 9.653542e-02 1.015 0 0
CREB phosphorylation R-HSA-199920 9.951761e-02 1.002 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 9.951761e-02 1.002 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.029649e-01 0.987 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 1.034405e-01 0.985 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 1.034405e-01 0.985 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.034824e-01 0.985 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.034824e-01 0.985 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.034824e-01 0.985 0 0
Formation of the anterior neural plate R-HSA-9823739 1.034824e-01 0.985 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.047886e-01 0.980 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.047886e-01 0.980 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.111916e-01 0.954 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.111916e-01 0.954 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.111916e-01 0.954 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.111916e-01 0.954 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.111916e-01 0.954 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.111916e-01 0.954 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.111916e-01 0.954 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.183592e-01 0.927 0 0
Netrin mediated repulsion signals R-HSA-418886 1.183592e-01 0.927 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 1.183592e-01 0.927 0 0
SOS-mediated signalling R-HSA-112412 1.183592e-01 0.927 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.183592e-01 0.927 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.183592e-01 0.927 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.379950e-01 0.860 0 0
Activation of RAS in B cells R-HSA-1169092 1.379950e-01 0.860 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.379950e-01 0.860 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 1.582726e-01 0.801 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.582726e-01 0.801 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.582726e-01 0.801 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.158097e-01 0.936 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.158097e-01 0.936 0 0
Phase 4 - resting membrane potential R-HSA-5576886 1.158097e-01 0.936 0 0
Phase 2 - plateau phase R-HSA-5576893 1.286556e-01 0.891 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.419782e-01 0.848 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.557354e-01 0.808 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 1.328647e-01 0.877 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.328647e-01 0.877 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.328647e-01 0.877 0 0
HIV elongation arrest and recovery R-HSA-167287 1.433590e-01 0.844 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.433590e-01 0.844 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.541668e-01 0.812 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.541668e-01 0.812 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.384459e-01 0.859 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.473834e-01 0.832 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 1.357362e-01 0.867 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 1.541668e-01 0.812 0 0
HIV Transcription Elongation R-HSA-167169 1.473834e-01 0.832 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 1.473834e-01 0.832 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 1.473834e-01 0.832 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.359625e-01 0.867 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 1.473834e-01 0.832 0 0
Signaling by FGFR R-HSA-190236 1.154367e-01 0.938 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 1.557354e-01 0.808 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 1.286556e-01 0.891 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.328647e-01 0.877 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.582726e-01 0.801 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.557354e-01 0.808 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 1.286556e-01 0.891 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.183592e-01 0.927 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 1.183592e-01 0.927 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.384459e-01 0.859 0 0
Insulin receptor signalling cascade R-HSA-74751 1.370596e-01 0.863 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.557354e-01 0.808 0 0
Adrenoceptors R-HSA-390696 1.379950e-01 0.860 0 0
GABA receptor activation R-HSA-977443 1.110107e-01 0.955 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 1.172580e-01 0.931 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.227020e-01 0.911 0 0
GPCR downstream signalling R-HSA-388396 1.270932e-01 0.896 0 0
Neurexins and neuroligins R-HSA-6794361 1.468122e-01 0.833 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 1.582726e-01 0.801 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.379950e-01 0.860 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 1.419782e-01 0.848 0 0
FGFR1 ligand binding and activation R-HSA-190242 1.557354e-01 0.808 0 0
mRNA Editing R-HSA-75072 1.582726e-01 0.801 0 0
Integration of energy metabolism R-HSA-163685 1.244070e-01 0.905 0 0
Gastrulation R-HSA-9758941 1.231354e-01 0.910 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.286556e-01 0.891 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 1.111916e-01 0.954 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 1.183592e-01 0.927 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 1.379950e-01 0.860 0 0
Synaptic adhesion-like molecules R-HSA-8849932 1.557354e-01 0.808 0 0
TGFBR3 expression R-HSA-9839394 1.128883e-01 0.947 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.541668e-01 0.812 0 0
PI3K Cascade R-HSA-109704 1.313931e-01 0.881 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.110107e-01 0.955 0 0
Transmission across Chemical Synapses R-HSA-112315 1.195632e-01 0.922 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.565592e-01 0.805 0 0
Signaling by NOTCH1 R-HSA-1980143 1.276918e-01 0.894 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.582726e-01 0.801 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 1.286556e-01 0.891 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.433590e-01 0.844 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.541668e-01 0.812 0 0
Prolonged ERK activation events R-HSA-169893 1.158097e-01 0.936 0 0
Formation of the nephric duct R-HSA-9830364 1.128883e-01 0.947 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.379950e-01 0.860 0 0
Interleukin-1 processing R-HSA-448706 1.582726e-01 0.801 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 1.582726e-01 0.801 0 0
Pyroptosis R-HSA-5620971 1.433590e-01 0.844 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.213251e-01 0.916 0 0
Uptake and function of anthrax toxins R-HSA-5210891 1.419782e-01 0.848 0 0
Potassium Channels R-HSA-1296071 1.058708e-01 0.975 0 0
Signaling by ROBO receptors R-HSA-376176 1.126310e-01 0.948 0 0
ARMS-mediated activation R-HSA-170984 1.582726e-01 0.801 0 0
Sensory processing of sound R-HSA-9659379 1.464316e-01 0.834 0 0
Glycolysis R-HSA-70171 1.254701e-01 0.901 0 0
Regulation of PTEN localization R-HSA-8948747 1.183592e-01 0.927 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 1.183592e-01 0.927 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 1.328647e-01 0.877 0 0
Signaling by TGFB family members R-HSA-9006936 1.102772e-01 0.958 0 0
PI Metabolism R-HSA-1483255 1.359625e-01 0.867 0 0
UCH proteinases R-HSA-5689603 1.276918e-01 0.894 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.594308e-01 0.797 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 1.620659e-01 0.790 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 1.620659e-01 0.790 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 1.620659e-01 0.790 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 1.620659e-01 0.790 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 1.620659e-01 0.790 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 1.620659e-01 0.790 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 1.620659e-01 0.790 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 1.620659e-01 0.790 0 0
Intestinal infectious diseases R-HSA-8942233 1.620659e-01 0.790 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 1.620659e-01 0.790 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.620659e-01 0.790 0 0
Adipogenesis R-HSA-9843745 1.646271e-01 0.783 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.652694e-01 0.782 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.652694e-01 0.782 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 1.652694e-01 0.782 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 1.652694e-01 0.782 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.652694e-01 0.782 0 0
Interleukin-37 signaling R-HSA-9008059 1.652694e-01 0.782 0 0
Transcription of the HIV genome R-HSA-167172 1.657994e-01 0.780 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.657994e-01 0.780 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.659629e-01 0.780 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.659629e-01 0.780 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.659629e-01 0.780 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 1.675215e-01 0.776 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 1.675215e-01 0.776 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 1.675215e-01 0.776 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 1.698853e-01 0.770 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.698853e-01 0.770 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.698853e-01 0.770 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 2.100311e-01 0.678 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 2.100311e-01 0.678 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 2.100311e-01 0.678 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 2.100311e-01 0.678 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 2.100311e-01 0.678 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 2.100311e-01 0.678 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 2.100311e-01 0.678 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 2.100311e-01 0.678 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 2.100311e-01 0.678 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 2.100311e-01 0.678 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 2.100311e-01 0.678 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 2.100311e-01 0.678 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 2.100311e-01 0.678 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 2.100311e-01 0.678 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 2.552535e-01 0.593 0 0
Axonal growth stimulation R-HSA-209563 2.552535e-01 0.593 0 0
Invadopodia formation R-HSA-8941237 2.552535e-01 0.593 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 2.552535e-01 0.593 0 0
Classical Kir channels R-HSA-1296053 2.552535e-01 0.593 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.978896e-01 0.526 0 0
Signaling by MAP2K mutants R-HSA-9652169 2.978896e-01 0.526 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 1.790545e-01 0.747 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.002166e-01 0.698 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 2.002166e-01 0.698 0 0
FGFR2b ligand binding and activation R-HSA-190377 2.002166e-01 0.698 0 0
Signaling by APC mutants R-HSA-4839744 2.002166e-01 0.698 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.002166e-01 0.698 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.002166e-01 0.698 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 2.002166e-01 0.698 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.002166e-01 0.698 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 3.380872e-01 0.471 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 3.380872e-01 0.471 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 3.380872e-01 0.471 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 2.216476e-01 0.654 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 2.216476e-01 0.654 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.216476e-01 0.654 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.843864e-01 0.734 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.843864e-01 0.734 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.843864e-01 0.734 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.843864e-01 0.734 0 0
FGFR2c ligand binding and activation R-HSA-190375 2.649268e-01 0.577 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 1.991979e-01 0.701 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 2.142798e-01 0.669 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 2.866058e-01 0.543 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 2.866058e-01 0.543 0 0
FGFR2 alternative splicing R-HSA-6803529 2.295934e-01 0.639 0 0
DCC mediated attractive signaling R-HSA-418885 3.082137e-01 0.511 0 0
Erythropoietin activates RAS R-HSA-9027284 3.082137e-01 0.511 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 3.082137e-01 0.511 0 0
SHC1 events in EGFR signaling R-HSA-180336 3.082137e-01 0.511 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 3.082137e-01 0.511 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 3.082137e-01 0.511 0 0
Interleukin receptor SHC signaling R-HSA-912526 2.451010e-01 0.611 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.607664e-01 0.584 0 0
Phosphorylation of the APC/C R-HSA-176412 3.296875e-01 0.482 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.296875e-01 0.482 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.765548e-01 0.558 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.160141e-01 0.666 0 0
Voltage gated Potassium channels R-HSA-1296072 2.623674e-01 0.581 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 3.243331e-01 0.489 0 0
Formation of the Early Elongation Complex R-HSA-113418 3.243331e-01 0.489 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.402964e-01 0.468 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 3.293389e-01 0.482 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 2.369880e-01 0.625 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 2.369880e-01 0.625 0 0
p75NTR signals via NF-kB R-HSA-193639 3.082137e-01 0.511 0 0
Signaling by SCF-KIT R-HSA-1433557 1.854109e-01 0.732 0 0
EGFR downregulation R-HSA-182971 1.766476e-01 0.753 0 0
Telomere Extension By Telomerase R-HSA-171319 3.243331e-01 0.489 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.330688e-01 0.633 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 1.852538e-01 0.732 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.790545e-01 0.747 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 3.082137e-01 0.511 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 3.135162e-01 0.504 0 0
Regulation of CDH11 function R-HSA-9762292 1.790545e-01 0.747 0 0
PI3K/AKT activation R-HSA-198203 1.790545e-01 0.747 0 0
Signalling to RAS R-HSA-167044 1.991979e-01 0.701 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.245257e-01 0.649 0 0
Myogenesis R-HSA-525793 2.924329e-01 0.534 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.245257e-01 0.649 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.924329e-01 0.534 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.122408e-01 0.673 0 0
Regulation of gap junction activity R-HSA-191650 2.978896e-01 0.526 0 0
NF-kB is activated and signals survival R-HSA-209560 2.216476e-01 0.654 0 0
Trafficking of AMPA receptors R-HSA-399719 1.766476e-01 0.753 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.001529e-01 0.699 0 0
Nuclear RNA decay R-HSA-9930044 2.001529e-01 0.699 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.767496e-01 0.753 0 0
G1/S Transition R-HSA-69206 3.145013e-01 0.502 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.432475e-01 0.614 0 0
Formation of the posterior neural plate R-HSA-9832991 2.002166e-01 0.698 0 0
FGFR3 ligand binding and activation R-HSA-190239 3.082137e-01 0.511 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.001529e-01 0.699 0 0
G protein gated Potassium channels R-HSA-1296059 2.765548e-01 0.558 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 2.765548e-01 0.558 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 2.765548e-01 0.558 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 2.056377e-01 0.687 0 0
IRS-mediated signalling R-HSA-112399 1.886401e-01 0.724 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.480524e-01 0.605 0 0
Aggrephagy R-HSA-9646399 3.012889e-01 0.521 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.832352e-01 0.548 0 0
G alpha (s) signalling events R-HSA-418555 2.362674e-01 0.627 0 0
Interleukin-2 signaling R-HSA-9020558 2.002166e-01 0.698 0 0
HCMV Infection R-HSA-9609646 2.489264e-01 0.604 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 3.380872e-01 0.471 0 0
p38MAPK events R-HSA-171007 3.082137e-01 0.511 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 3.082137e-01 0.511 0 0
Inwardly rectifying K+ channels R-HSA-1296065 1.882820e-01 0.725 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 2.122408e-01 0.673 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 2.122408e-01 0.673 0 0
Signaling by FGFR in disease R-HSA-1226099 2.133386e-01 0.671 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.036244e-01 0.691 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 2.439949e-01 0.613 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.919838e-01 0.717 0 0
Metabolism of RNA R-HSA-8953854 3.231021e-01 0.491 0 0
mRNA Editing: A to I Conversion R-HSA-75064 2.100311e-01 0.678 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 2.100311e-01 0.678 0 0
C6 deamination of adenosine R-HSA-75102 2.100311e-01 0.678 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 2.552535e-01 0.593 0 0
Ionotropic activity of kainate receptors R-HSA-451306 2.002166e-01 0.698 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 3.380872e-01 0.471 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.216476e-01 0.654 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 2.216476e-01 0.654 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.216476e-01 0.654 0 0
Signaling by AXIN mutants R-HSA-4839735 2.216476e-01 0.654 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 2.432475e-01 0.614 0 0
FGFR4 ligand binding and activation R-HSA-190322 2.649268e-01 0.577 0 0
FGFR3c ligand binding and activation R-HSA-190372 2.866058e-01 0.543 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 3.082137e-01 0.511 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 2.122408e-01 0.673 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.245257e-01 0.649 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 2.245257e-01 0.649 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 2.752461e-01 0.560 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.107102e-01 0.508 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 2.607664e-01 0.584 0 0
FGFR2 mutant receptor activation R-HSA-1839126 2.496083e-01 0.603 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 2.245257e-01 0.649 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.369880e-01 0.625 0 0
FLT3 signaling in disease R-HSA-9682385 2.496083e-01 0.603 0 0
Disorders of Nervous System Development R-HSA-9697154 2.432475e-01 0.614 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.432475e-01 0.614 0 0
Pervasive developmental disorders R-HSA-9005895 2.432475e-01 0.614 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 2.001529e-01 0.699 0 0
Amine ligand-binding receptors R-HSA-375280 1.954327e-01 0.709 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.790545e-01 0.747 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 1.847558e-01 0.733 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.432475e-01 0.614 0 0
Regulation of BACH1 activity R-HSA-9708530 3.296875e-01 0.482 0 0
Platelet calcium homeostasis R-HSA-418360 3.402964e-01 0.468 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 1.847558e-01 0.733 0 0
Regulation of insulin secretion R-HSA-422356 3.158350e-01 0.501 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 3.012889e-01 0.521 0 0
Diseases of Immune System R-HSA-5260271 3.012889e-01 0.521 0 0
Interleukin-15 signaling R-HSA-8983432 2.432475e-01 0.614 0 0
Signaling by GPCR R-HSA-372790 2.446129e-01 0.612 0 0
DSCAM interactions R-HSA-376172 2.100311e-01 0.678 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 2.552535e-01 0.593 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 2.978896e-01 0.526 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 1.790545e-01 0.747 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 3.380872e-01 0.471 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 2.649268e-01 0.577 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.001529e-01 0.699 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 2.607664e-01 0.584 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.402964e-01 0.468 0 0
Hedgehog 'off' state R-HSA-5610787 2.127840e-01 0.672 0 0
Cell-extracellular matrix interactions R-HSA-446353 3.082137e-01 0.511 0 0
Adaptive Immune System R-HSA-1280218 1.924839e-01 0.716 1 0
Histamine receptors R-HSA-390650 2.552535e-01 0.593 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 2.924329e-01 0.534 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.623674e-01 0.581 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.050271e-01 0.688 1 0
Ion channel transport R-HSA-983712 1.734862e-01 0.761 0 0
Spry regulation of FGF signaling R-HSA-1295596 3.082137e-01 0.511 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 2.100311e-01 0.678 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 2.552535e-01 0.593 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 2.552535e-01 0.593 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.978896e-01 0.526 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 3.380872e-01 0.471 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 2.649268e-01 0.577 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 2.649268e-01 0.577 0 0
Negative regulation of FLT3 R-HSA-9706369 3.296875e-01 0.482 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 3.296875e-01 0.482 0 0
Interaction between L1 and Ankyrins R-HSA-445095 3.083691e-01 0.511 0 0
Regulation of gene expression in beta cells R-HSA-210745 3.402964e-01 0.468 0 0
Regulated Necrosis R-HSA-5218859 2.932616e-01 0.533 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 1.991979e-01 0.701 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.369880e-01 0.625 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.798811e-01 0.553 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 3.391423e-01 0.470 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.001529e-01 0.699 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 3.107102e-01 0.508 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 2.432475e-01 0.614 0 0
Activation of SMO R-HSA-5635838 3.296875e-01 0.482 0 0
Signaling by Hedgehog R-HSA-5358351 3.095852e-01 0.509 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 3.380872e-01 0.471 0 0
FGFR3 mutant receptor activation R-HSA-2033514 2.649268e-01 0.577 0 0
Syndecan interactions R-HSA-3000170 2.451010e-01 0.611 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.988176e-01 0.702 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.988176e-01 0.702 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.988176e-01 0.702 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.919838e-01 0.717 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.876924e-01 0.541 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 2.876924e-01 0.541 0 0
Glucose metabolism R-HSA-70326 2.487022e-01 0.604 0 0
Physiological factors R-HSA-5578768 2.866058e-01 0.543 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 3.194708e-01 0.496 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.924329e-01 0.534 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 3.380872e-01 0.471 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 3.296875e-01 0.482 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.644458e-01 0.578 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 2.866058e-01 0.543 0 0
Miscellaneous transport and binding events R-HSA-5223345 2.122408e-01 0.673 0 0
Signaling by Leptin R-HSA-2586552 1.790545e-01 0.747 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.023270e-01 0.694 0 0
IRE1alpha activates chaperones R-HSA-381070 2.490208e-01 0.604 0 0
Plasma lipoprotein assembly R-HSA-8963898 2.607664e-01 0.584 0 0
Activation of GABAB receptors R-HSA-991365 3.407999e-01 0.468 0 0
GABA B receptor activation R-HSA-977444 3.407999e-01 0.468 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 3.407999e-01 0.468 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.407999e-01 0.468 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.437545e-01 0.464 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.509720e-01 0.455 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 3.509720e-01 0.455 0 0
Disorders of Developmental Biology R-HSA-9675151 3.509720e-01 0.455 0 0
Synthesis of PG R-HSA-1483148 3.509720e-01 0.455 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 3.562323e-01 0.448 0 0
Regulation of beta-cell development R-HSA-186712 3.610852e-01 0.442 0 0
Hemostasis R-HSA-109582 3.718963e-01 0.430 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 3.720183e-01 0.429 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.720183e-01 0.429 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 3.720183e-01 0.429 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.720183e-01 0.429 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.720183e-01 0.429 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 3.720183e-01 0.429 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 3.721155e-01 0.429 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 3.726217e-01 0.429 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 3.726217e-01 0.429 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 3.726217e-01 0.429 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 3.726217e-01 0.429 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 3.726217e-01 0.429 0 0
PKB-mediated events R-HSA-109703 3.759858e-01 0.425 0 0
PDE3B signalling R-HSA-165160 3.759858e-01 0.425 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 3.759858e-01 0.425 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 3.759858e-01 0.425 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 3.759858e-01 0.425 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 3.759858e-01 0.425 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.759858e-01 0.425 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 3.759858e-01 0.425 0 0
Signaling by RNF43 mutants R-HSA-5340588 3.759858e-01 0.425 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 3.759858e-01 0.425 0 0
Ceramide signalling R-HSA-193681 3.759858e-01 0.425 0 0
Phosphorylation of Emi1 R-HSA-176417 3.759858e-01 0.425 0 0
Formation of the Editosome R-HSA-75094 3.759858e-01 0.425 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 3.759858e-01 0.425 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.759858e-01 0.425 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 3.759858e-01 0.425 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 3.759858e-01 0.425 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 3.804496e-01 0.420 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.804496e-01 0.420 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 3.841577e-01 0.415 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 3.856134e-01 0.414 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 3.860024e-01 0.413 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 3.879222e-01 0.411 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 3.896782e-01 0.409 0 0
GAB1 signalosome R-HSA-180292 3.927843e-01 0.406 0 0
Activated point mutants of FGFR2 R-HSA-2033519 3.927843e-01 0.406 0 0
Tie2 Signaling R-HSA-210993 3.927843e-01 0.406 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.927843e-01 0.406 0 0
Diseases of DNA repair R-HSA-9675135 3.936257e-01 0.405 0 0
Signaling by Insulin receptor R-HSA-74752 3.954978e-01 0.403 0 0
Heme signaling R-HSA-9707616 3.956833e-01 0.403 0 0
Gene Silencing by RNA R-HSA-211000 4.032358e-01 0.394 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 4.036305e-01 0.394 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 4.036305e-01 0.394 0 0
G-protein beta:gamma signalling R-HSA-397795 4.036305e-01 0.394 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 4.064036e-01 0.391 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 4.064036e-01 0.391 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 4.067580e-01 0.391 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.071889e-01 0.390 0 0
Signaling by PTK6 R-HSA-8848021 4.071889e-01 0.390 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 4.117165e-01 0.385 0 0
STAT5 Activation R-HSA-9645135 4.117165e-01 0.385 0 0
Erythropoietin activates STAT5 R-HSA-9027283 4.117165e-01 0.385 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 4.117165e-01 0.385 0 0
Abacavir transmembrane transport R-HSA-2161517 4.117165e-01 0.385 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 4.117165e-01 0.385 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 4.132328e-01 0.384 0 0
The NLRP3 inflammasome R-HSA-844456 4.132328e-01 0.384 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.167482e-01 0.380 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 4.192199e-01 0.378 0 0
Effects of PIP2 hydrolysis R-HSA-114508 4.192199e-01 0.378 0 0
Interleukin-1 family signaling R-HSA-446652 4.193023e-01 0.377 0 0
Intraflagellar transport R-HSA-5620924 4.198335e-01 0.377 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 4.198335e-01 0.377 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 4.239597e-01 0.373 0 0
DNA Replication R-HSA-69306 4.267140e-01 0.370 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.296558e-01 0.367 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.296558e-01 0.367 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 4.333324e-01 0.363 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 4.333324e-01 0.363 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.333324e-01 0.363 0 0
Signal transduction by L1 R-HSA-445144 4.333324e-01 0.363 0 0
Signal amplification R-HSA-392518 4.346713e-01 0.362 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 4.346713e-01 0.362 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 4.454034e-01 0.351 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 4.454034e-01 0.351 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 4.454034e-01 0.351 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 4.454034e-01 0.351 0 0
FGFR3b ligand binding and activation R-HSA-190371 4.454034e-01 0.351 0 0
Disinhibition of SNARE formation R-HSA-114516 4.454034e-01 0.351 0 0
mRNA Editing: C to U Conversion R-HSA-72200 4.454034e-01 0.351 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 4.454034e-01 0.351 0 0
Ca2+ activated K+ channels R-HSA-1296052 4.454034e-01 0.351 0 0
Glycoprotein hormones R-HSA-209822 4.454034e-01 0.351 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 4.454034e-01 0.351 0 0
Signaling by FGFR2 in disease R-HSA-5655253 4.457647e-01 0.351 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 4.472100e-01 0.349 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 4.472100e-01 0.349 0 0
G-protein activation R-HSA-202040 4.530559e-01 0.344 0 0
FGFR2 ligand binding and activation R-HSA-190241 4.530559e-01 0.344 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 4.530559e-01 0.344 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 4.530559e-01 0.344 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 4.530559e-01 0.344 0 0
HCMV Late Events R-HSA-9610379 4.563061e-01 0.341 0 0
HSF1-dependent transactivation R-HSA-3371571 4.585974e-01 0.339 0 0
Neutrophil degranulation R-HSA-6798695 4.629337e-01 0.334 0 0
G1/S-Specific Transcription R-HSA-69205 4.650918e-01 0.332 0 0
Triglyceride catabolism R-HSA-163560 4.650918e-01 0.332 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 4.713272e-01 0.327 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 4.713272e-01 0.327 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 4.723805e-01 0.326 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.723805e-01 0.326 0 0
Signaling by PDGFR in disease R-HSA-9671555 4.723805e-01 0.326 0 0
Type I hemidesmosome assembly R-HSA-446107 4.771632e-01 0.321 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 4.771632e-01 0.321 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 4.771632e-01 0.321 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 4.771632e-01 0.321 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 4.771632e-01 0.321 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.771632e-01 0.321 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 4.771632e-01 0.321 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 4.771632e-01 0.321 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 4.771632e-01 0.321 0 0
Alpha-defensins R-HSA-1462054 4.771632e-01 0.321 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 4.771632e-01 0.321 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 4.771632e-01 0.321 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 4.800301e-01 0.319 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.839442e-01 0.315 0 0
Smooth Muscle Contraction R-HSA-445355 4.839442e-01 0.315 0 0
Interleukin-1 signaling R-HSA-9020702 4.895673e-01 0.310 0 0
Signaling by KIT in disease R-HSA-9669938 4.912873e-01 0.309 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 4.912873e-01 0.309 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 4.912873e-01 0.309 0 0
Notch-HLH transcription pathway R-HSA-350054 4.912873e-01 0.309 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 4.912873e-01 0.309 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 4.912873e-01 0.309 0 0
Translation initiation complex formation R-HSA-72649 4.964391e-01 0.304 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.964391e-01 0.304 0 0
Hedgehog 'on' state R-HSA-5632684 4.974756e-01 0.303 0 0
ALK mutants bind TKIs R-HSA-9700645 5.071060e-01 0.295 0 0
p75NTR regulates axonogenesis R-HSA-193697 5.071060e-01 0.295 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 5.071060e-01 0.295 0 0
Regulation of signaling by NODAL R-HSA-1433617 5.071060e-01 0.295 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 5.071060e-01 0.295 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 5.071060e-01 0.295 0 0
GP1b-IX-V activation signalling R-HSA-430116 5.071060e-01 0.295 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 5.084257e-01 0.294 0 0
Signaling by NOTCH3 R-HSA-9012852 5.088032e-01 0.293 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 5.092960e-01 0.293 0 0
Stabilization of p53 R-HSA-69541 5.092960e-01 0.293 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 5.097608e-01 0.293 0 0
Growth hormone receptor signaling R-HSA-982772 5.097608e-01 0.293 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.210285e-01 0.283 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 5.210285e-01 0.283 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 5.236006e-01 0.281 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 5.236006e-01 0.281 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 5.236006e-01 0.281 0 0
Interleukin-2 family signaling R-HSA-451927 5.236006e-01 0.281 0 0
Co-inhibition by PD-1 R-HSA-389948 5.272511e-01 0.278 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 5.277885e-01 0.278 0 0
Deadenylation of mRNA R-HSA-429947 5.277885e-01 0.278 0 0
Thromboxane signalling through TP receptor R-HSA-428930 5.277885e-01 0.278 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 5.277885e-01 0.278 0 0
Cellular response to chemical stress R-HSA-9711123 5.304823e-01 0.275 0 0
MAPK3 (ERK1) activation R-HSA-110056 5.353356e-01 0.271 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 5.353356e-01 0.271 0 0
2-LTR circle formation R-HSA-164843 5.353356e-01 0.271 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 5.353356e-01 0.271 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 5.353356e-01 0.271 0 0
Formation of intermediate mesoderm R-HSA-9761174 5.353356e-01 0.271 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 5.353356e-01 0.271 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 5.353356e-01 0.271 0 0
Maturation of spike protein R-HSA-9683686 5.353356e-01 0.271 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 5.353356e-01 0.271 0 0
Peptide hormone biosynthesis R-HSA-209952 5.353356e-01 0.271 0 0
Tandem pore domain potassium channels R-HSA-1296346 5.353356e-01 0.271 0 0
Receptor Mediated Mitophagy R-HSA-8934903 5.353356e-01 0.271 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 5.376731e-01 0.269 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 5.406701e-01 0.267 0 0
ISG15 antiviral mechanism R-HSA-1169408 5.406701e-01 0.267 0 0
Dual incision in TC-NER R-HSA-6782135 5.450331e-01 0.264 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 5.450331e-01 0.264 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 5.453610e-01 0.263 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 5.453610e-01 0.263 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 5.453610e-01 0.263 0 0
Tight junction interactions R-HSA-420029 5.453610e-01 0.263 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 5.453610e-01 0.263 0 0
Acyl chain remodelling of PS R-HSA-1482801 5.453610e-01 0.263 0 0
Interleukin-7 signaling R-HSA-1266695 5.453610e-01 0.263 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 5.515050e-01 0.258 0 0
HIV Transcription Initiation R-HSA-167161 5.515050e-01 0.258 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 5.515050e-01 0.258 0 0
Intra-Golgi traffic R-HSA-6811438 5.515050e-01 0.258 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 5.515050e-01 0.258 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 5.515050e-01 0.258 0 0
Metabolism of non-coding RNA R-HSA-194441 5.567993e-01 0.254 0 0
snRNP Assembly R-HSA-191859 5.567993e-01 0.254 0 0
Extension of Telomeres R-HSA-180786 5.567993e-01 0.254 0 0
Triglyceride metabolism R-HSA-8979227 5.567993e-01 0.254 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 5.597797e-01 0.252 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 5.615486e-01 0.251 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 5.615486e-01 0.251 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 5.616076e-01 0.251 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 5.619501e-01 0.250 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 5.619501e-01 0.250 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 5.619501e-01 0.250 0 0
Bicarbonate transporters R-HSA-425381 5.619501e-01 0.250 0 0
LGI-ADAM interactions R-HSA-5682910 5.619501e-01 0.250 0 0
PECAM1 interactions R-HSA-210990 5.619501e-01 0.250 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 5.619501e-01 0.250 0 0
Signaling by EGFR in Cancer R-HSA-1643713 5.624712e-01 0.250 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 5.624712e-01 0.250 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 5.624712e-01 0.250 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 5.624712e-01 0.250 0 0
Platelet activation, signaling and aggregation R-HSA-76002 5.645062e-01 0.248 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 5.660601e-01 0.247 0 0
Regulation of PTEN gene transcription R-HSA-8943724 5.684002e-01 0.245 0 0
Unfolded Protein Response (UPR) R-HSA-381119 5.703116e-01 0.244 0 0
Cilium Assembly R-HSA-5617833 5.750960e-01 0.240 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 5.784176e-01 0.238 0 0
TBC/RABGAPs R-HSA-8854214 5.784176e-01 0.238 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 5.791146e-01 0.237 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 5.791146e-01 0.237 0 0
Signaling by FGFR3 in disease R-HSA-5655332 5.791146e-01 0.237 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 5.791146e-01 0.237 0 0
Aquaporin-mediated transport R-HSA-445717 5.798304e-01 0.237 0 0
MAP kinase activation R-HSA-450294 5.798304e-01 0.237 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.870417e-01 0.231 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 5.870417e-01 0.231 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 5.870417e-01 0.231 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 5.870417e-01 0.231 0 0
ERKs are inactivated R-HSA-202670 5.870417e-01 0.231 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.870417e-01 0.231 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 5.870417e-01 0.231 0 0
Sodium/Calcium exchangers R-HSA-425561 5.870417e-01 0.231 0 0
Integration of provirus R-HSA-162592 5.870417e-01 0.231 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 5.870417e-01 0.231 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.910853e-01 0.228 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 5.914864e-01 0.228 0 0
PKR-mediated signaling R-HSA-9833482 5.920827e-01 0.228 0 0
Formation of a pool of free 40S subunits R-HSA-72689 5.937542e-01 0.226 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 5.952883e-01 0.225 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 5.952883e-01 0.225 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 5.952883e-01 0.225 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 5.952883e-01 0.225 0 0
Inflammasomes R-HSA-622312 5.952883e-01 0.225 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 5.952883e-01 0.225 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 6.021607e-01 0.220 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 6.042904e-01 0.219 0 0
G alpha (q) signalling events R-HSA-416476 6.058004e-01 0.218 0 0
p75NTR recruits signalling complexes R-HSA-209543 6.106975e-01 0.214 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 6.106975e-01 0.214 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 6.106975e-01 0.214 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 6.106975e-01 0.214 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 6.106975e-01 0.214 0 0
IRAK1 recruits IKK complex R-HSA-937039 6.106975e-01 0.214 0 0
GRB2 events in EGFR signaling R-HSA-179812 6.106975e-01 0.214 0 0
MET activates RAS signaling R-HSA-8851805 6.106975e-01 0.214 0 0
Polymerase switching R-HSA-69091 6.106975e-01 0.214 0 0
Leading Strand Synthesis R-HSA-69109 6.106975e-01 0.214 0 0
Estrogen biosynthesis R-HSA-193144 6.106975e-01 0.214 0 0
OAS antiviral response R-HSA-8983711 6.106975e-01 0.214 0 0
Signaling by Erythropoietin R-HSA-9006335 6.109917e-01 0.214 0 0
mRNA Capping R-HSA-72086 6.109917e-01 0.214 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 6.109917e-01 0.214 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 6.109917e-01 0.214 0 0
Ion transport by P-type ATPases R-HSA-936837 6.130528e-01 0.213 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 6.130528e-01 0.213 0 0
Membrane Trafficking R-HSA-199991 6.143516e-01 0.212 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 6.168258e-01 0.210 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 6.168258e-01 0.210 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 6.168258e-01 0.210 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 6.168258e-01 0.210 0 0
Cellular response to hypoxia R-HSA-1234174 6.237583e-01 0.205 0 0
DAP12 signaling R-HSA-2424491 6.262254e-01 0.203 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 6.262254e-01 0.203 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 6.290895e-01 0.201 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 6.329996e-01 0.199 0 0
Adenylate cyclase activating pathway R-HSA-170660 6.329996e-01 0.199 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 6.329996e-01 0.199 0 0
Chylomicron remodeling R-HSA-8963901 6.329996e-01 0.199 0 0
Mtb iron assimilation by chelation R-HSA-1222449 6.329996e-01 0.199 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 6.329996e-01 0.199 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 6.329996e-01 0.199 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 6.409919e-01 0.193 0 0
Downstream signal transduction R-HSA-186763 6.409919e-01 0.193 0 0
Cap-dependent Translation Initiation R-HSA-72737 6.444275e-01 0.191 0 0
Eukaryotic Translation Initiation R-HSA-72613 6.444275e-01 0.191 0 0
Kidney development R-HSA-9830369 6.445986e-01 0.191 0 0
Rab regulation of trafficking R-HSA-9007101 6.521949e-01 0.186 0 0
Degradation of CDH1 R-HSA-9766229 6.527941e-01 0.185 0 0
Removal of the Flap Intermediate R-HSA-69166 6.540252e-01 0.184 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 6.540252e-01 0.184 0 0
CRMPs in Sema3A signaling R-HSA-399956 6.540252e-01 0.184 0 0
NRIF signals cell death from the nucleus R-HSA-205043 6.540252e-01 0.184 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 6.540252e-01 0.184 0 0
cGMP effects R-HSA-418457 6.540252e-01 0.184 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 6.540252e-01 0.184 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 6.540252e-01 0.184 0 0
Non-canonical inflammasome activation R-HSA-9686114 6.540252e-01 0.184 0 0
Signal regulatory protein family interactions R-HSA-391160 6.540252e-01 0.184 0 0
P2Y receptors R-HSA-417957 6.540252e-01 0.184 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 6.547289e-01 0.184 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 6.691381e-01 0.174 0 0
Activation of ATR in response to replication stress R-HSA-176187 6.691381e-01 0.174 0 0
Regulation of necroptotic cell death R-HSA-5675482 6.691381e-01 0.174 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 6.738475e-01 0.171 0 0
G beta:gamma signalling through BTK R-HSA-8964315 6.738475e-01 0.171 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.738475e-01 0.171 0 0
Telomere C-strand synthesis initiation R-HSA-174430 6.738475e-01 0.171 0 0
Translesion synthesis by REV1 R-HSA-110312 6.738475e-01 0.171 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 6.738475e-01 0.171 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.738475e-01 0.171 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 6.738475e-01 0.171 0 0
Interleukin-17 signaling R-HSA-448424 6.744018e-01 0.171 0 0
Phospholipid metabolism R-HSA-1483257 6.752384e-01 0.171 0 0
Peptide chain elongation R-HSA-156902 6.759688e-01 0.170 0 0
Selective autophagy R-HSA-9663891 6.759688e-01 0.170 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 6.822356e-01 0.166 0 0
Cellular response to heat stress R-HSA-3371556 6.822356e-01 0.166 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 6.825281e-01 0.166 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 6.839422e-01 0.165 0 0
Regulation of mitotic cell cycle R-HSA-453276 6.839422e-01 0.165 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 6.862797e-01 0.163 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 6.862797e-01 0.163 0 0
Nucleotide Excision Repair R-HSA-5696398 6.866129e-01 0.163 0 0
Toll-like Receptor Cascades R-HSA-168898 6.924442e-01 0.160 0 0
Translesion synthesis by POLI R-HSA-5656121 6.925353e-01 0.160 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 6.925353e-01 0.160 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 6.925353e-01 0.160 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 6.925353e-01 0.160 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.925353e-01 0.160 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 6.925353e-01 0.160 0 0
Synthesis of wybutosine at G37 of tRNA(Phe) R-HSA-6782861 6.925353e-01 0.160 0 0
Atorvastatin ADME R-HSA-9754706 6.925353e-01 0.160 0 0
Platelet homeostasis R-HSA-418346 6.943221e-01 0.158 0 0
eNOS activation R-HSA-203615 6.954712e-01 0.158 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 6.954712e-01 0.158 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.954712e-01 0.158 0 0
NOD1/2 Signaling Pathway R-HSA-168638 6.954712e-01 0.158 0 0
Signaling by NOTCH2 R-HSA-1980145 6.954712e-01 0.158 0 0
PTEN Regulation R-HSA-6807070 6.994768e-01 0.155 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 7.012266e-01 0.154 0 0
Ca2+ pathway R-HSA-4086398 7.024280e-01 0.153 0 0
HIV Life Cycle R-HSA-162587 7.026635e-01 0.153 0 0
SARS-CoV-1 Infection R-HSA-9678108 7.060503e-01 0.151 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.088547e-01 0.149 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 7.101533e-01 0.149 0 0
Translesion synthesis by POLK R-HSA-5655862 7.101533e-01 0.149 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 7.101533e-01 0.149 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 7.101533e-01 0.149 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 7.101533e-01 0.149 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 7.101533e-01 0.149 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 7.101533e-01 0.149 0 0
Eukaryotic Translation Elongation R-HSA-156842 7.172890e-01 0.144 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 7.172891e-01 0.144 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 7.200460e-01 0.143 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 7.200460e-01 0.143 0 0
RUNX2 regulates bone development R-HSA-8941326 7.200460e-01 0.143 0 0
Protein ubiquitination R-HSA-8852135 7.201203e-01 0.143 0 0
Late Phase of HIV Life Cycle R-HSA-162599 7.252176e-01 0.140 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 7.267628e-01 0.139 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 7.267628e-01 0.139 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 7.267628e-01 0.139 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 7.267628e-01 0.139 0 0
Sulfide oxidation to sulfate R-HSA-1614517 7.267628e-01 0.139 0 0
Choline catabolism R-HSA-6798163 7.267628e-01 0.139 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 7.267628e-01 0.139 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 7.267628e-01 0.139 0 0
Regulation of CDH1 Function R-HSA-9764561 7.366076e-01 0.133 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 7.402151e-01 0.131 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 7.424215e-01 0.129 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 7.424215e-01 0.129 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 7.424215e-01 0.129 0 0
Chaperone Mediated Autophagy R-HSA-9613829 7.424215e-01 0.129 0 0
Transport of connexons to the plasma membrane R-HSA-190872 7.424215e-01 0.129 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 7.424215e-01 0.129 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 7.424215e-01 0.129 0 0
Apoptotic factor-mediated response R-HSA-111471 7.424215e-01 0.129 0 0
Platelet sensitization by LDL R-HSA-432142 7.424215e-01 0.129 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 7.424215e-01 0.129 0 0
Mismatch Repair R-HSA-5358508 7.424215e-01 0.129 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 7.429276e-01 0.129 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 7.429276e-01 0.129 0 0
Interleukin-10 signaling R-HSA-6783783 7.451799e-01 0.128 0 0
Integrin cell surface interactions R-HSA-216083 7.451799e-01 0.128 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 7.458679e-01 0.127 0 0
Eukaryotic Translation Termination R-HSA-72764 7.475468e-01 0.126 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 7.537558e-01 0.123 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 7.571837e-01 0.121 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 7.571837e-01 0.121 0 0
E2F mediated regulation of DNA replication R-HSA-113510 7.571837e-01 0.121 0 0
Other interleukin signaling R-HSA-449836 7.571837e-01 0.121 0 0
RAB geranylgeranylation R-HSA-8873719 7.636064e-01 0.117 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 7.641882e-01 0.117 0 0
Attenuation phase R-HSA-3371568 7.641882e-01 0.117 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 7.643740e-01 0.117 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.684915e-01 0.114 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 7.711006e-01 0.113 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 7.711006e-01 0.113 0 0
Signaling by NODAL R-HSA-1181150 7.711006e-01 0.113 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 7.711006e-01 0.113 0 0
Pregnenolone biosynthesis R-HSA-196108 7.711006e-01 0.113 0 0
Formation of paraxial mesoderm R-HSA-9793380 7.720917e-01 0.112 0 0
Potential therapeutics for SARS R-HSA-9679191 7.721176e-01 0.112 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 7.738041e-01 0.111 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 7.742346e-01 0.111 0 0
Maturation of spike protein R-HSA-9694548 7.742346e-01 0.111 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 7.742346e-01 0.111 0 0
NCAM signaling for neurite out-growth R-HSA-375165 7.803261e-01 0.108 0 0
Signaling by PDGF R-HSA-186797 7.803261e-01 0.108 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.808446e-01 0.107 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 7.828871e-01 0.106 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 7.839050e-01 0.106 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.839050e-01 0.106 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 7.839050e-01 0.106 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 7.842208e-01 0.106 0 0
Lagging Strand Synthesis R-HSA-69186 7.842208e-01 0.106 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.842208e-01 0.106 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 7.842208e-01 0.106 0 0
ERK/MAPK targets R-HSA-198753 7.842208e-01 0.106 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 7.842208e-01 0.106 0 0
Basigin interactions R-HSA-210991 7.842208e-01 0.106 0 0
Early Phase of HIV Life Cycle R-HSA-162594 7.842208e-01 0.106 0 0
Selenocysteine synthesis R-HSA-2408557 7.883265e-01 0.103 0 0
SARS-CoV-2-host interactions R-HSA-9705683 7.904876e-01 0.102 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 7.932094e-01 0.101 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 7.965896e-01 0.099 0 0
Glutathione synthesis and recycling R-HSA-174403 7.965896e-01 0.099 0 0
Mitochondrial calcium ion transport R-HSA-8949215 7.965896e-01 0.099 0 0
Viral mRNA Translation R-HSA-192823 8.007230e-01 0.097 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 8.035875e-01 0.095 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 8.067031e-01 0.093 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.082501e-01 0.092 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 8.082501e-01 0.092 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 8.082501e-01 0.092 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 8.082501e-01 0.092 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 8.082501e-01 0.092 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 8.082501e-01 0.092 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 8.100630e-01 0.091 0 0
DAP12 interactions R-HSA-2172127 8.107611e-01 0.091 0 0
Surfactant metabolism R-HSA-5683826 8.107611e-01 0.091 0 0
Interferon Signaling R-HSA-913531 8.129112e-01 0.090 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.129112e-01 0.090 0 0
Chaperonin-mediated protein folding R-HSA-390466 8.163632e-01 0.088 0 0
Interferon gamma signaling R-HSA-877300 8.176262e-01 0.087 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.190287e-01 0.087 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.190287e-01 0.087 0 0
Fanconi Anemia Pathway R-HSA-6783310 8.190287e-01 0.087 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.192429e-01 0.087 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.192429e-01 0.087 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 8.192429e-01 0.087 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 8.192429e-01 0.087 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 8.192429e-01 0.087 0 0
Macroautophagy R-HSA-1632852 8.214683e-01 0.085 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 8.247034e-01 0.084 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.269711e-01 0.083 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 8.292074e-01 0.081 0 0
G alpha (i) signalling events R-HSA-418594 8.293307e-01 0.081 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 8.296061e-01 0.081 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 8.296061e-01 0.081 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.296061e-01 0.081 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 8.296061e-01 0.081 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 8.296061e-01 0.081 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 8.296061e-01 0.081 0 0
Complex III assembly R-HSA-9865881 8.296061e-01 0.081 0 0
TNFs bind their physiological receptors R-HSA-5669034 8.296061e-01 0.081 0 0
Antigen processing-Cross presentation R-HSA-1236975 8.344885e-01 0.079 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 8.366869e-01 0.077 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 8.376899e-01 0.077 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.393757e-01 0.076 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.393757e-01 0.076 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 8.393757e-01 0.076 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 8.393757e-01 0.076 0 0
Platelet degranulation R-HSA-114608 8.414215e-01 0.075 0 0
Organelle biogenesis and maintenance R-HSA-1852241 8.481459e-01 0.072 0 0
MET activates PTK2 signaling R-HSA-8874081 8.485858e-01 0.071 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 8.485858e-01 0.071 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 8.485858e-01 0.071 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.485858e-01 0.071 0 0
Abacavir ADME R-HSA-2161522 8.485858e-01 0.071 0 0
DNA Damage Bypass R-HSA-73893 8.489475e-01 0.071 0 0
Gap junction trafficking and regulation R-HSA-157858 8.489475e-01 0.071 0 0
Protein folding R-HSA-391251 8.506387e-01 0.070 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 8.506387e-01 0.070 0 0
Regulation of RAS by GAPs R-HSA-5658442 8.556889e-01 0.068 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 8.572683e-01 0.067 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.572683e-01 0.067 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.572683e-01 0.067 0 0
Triglyceride biosynthesis R-HSA-75109 8.572683e-01 0.067 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 8.572683e-01 0.067 0 0
Synthesis of PE R-HSA-1483213 8.572683e-01 0.067 0 0
Signaling by BMP R-HSA-201451 8.572683e-01 0.067 0 0
HIV Infection R-HSA-162906 8.603071e-01 0.065 0 0
Collagen formation R-HSA-1474290 8.607915e-01 0.065 0 0
Signaling by NOTCH4 R-HSA-9013694 8.611861e-01 0.065 0 0
ROS and RNS production in phagocytes R-HSA-1222556 8.611861e-01 0.065 0 0
The phototransduction cascade R-HSA-2514856 8.621546e-01 0.064 0 0
Prednisone ADME R-HSA-9757110 8.654534e-01 0.063 0 0
Pyrimidine salvage R-HSA-73614 8.654534e-01 0.063 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 8.665729e-01 0.062 0 0
Circadian clock R-HSA-9909396 8.675376e-01 0.062 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.705903e-01 0.060 1 0
Late endosomal microautophagy R-HSA-9615710 8.731695e-01 0.059 0 0
Thyroxine biosynthesis R-HSA-209968 8.731695e-01 0.059 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 8.731695e-01 0.059 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.731695e-01 0.059 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.742959e-01 0.058 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.742959e-01 0.058 0 0
COPI-mediated anterograde transport R-HSA-6807878 8.749123e-01 0.058 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 8.804436e-01 0.055 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.804436e-01 0.055 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 8.804436e-01 0.055 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.804436e-01 0.055 0 0
PPARA activates gene expression R-HSA-1989781 8.830241e-01 0.054 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 8.830241e-01 0.054 0 0
G alpha (z) signalling events R-HSA-418597 8.854449e-01 0.053 0 0
Autophagy R-HSA-9612973 8.864093e-01 0.052 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 8.873010e-01 0.052 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 8.873010e-01 0.052 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 8.873010e-01 0.052 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.873010e-01 0.052 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.873010e-01 0.052 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 8.873010e-01 0.052 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.897120e-01 0.051 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.906694e-01 0.050 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.906694e-01 0.050 0 0
Cellular response to starvation R-HSA-9711097 8.929336e-01 0.049 0 0
DNA strand elongation R-HSA-69190 8.937654e-01 0.049 0 0
Synthesis of PA R-HSA-1483166 8.956719e-01 0.048 0 0
Influenza Infection R-HSA-168255 8.964340e-01 0.047 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 8.998593e-01 0.046 0 0
Defective B3GALTL causes PpS R-HSA-5083635 8.998593e-01 0.046 0 0
Viral Infection Pathways R-HSA-9824446 9.021965e-01 0.045 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.034123e-01 0.044 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 9.050438e-01 0.043 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 9.056041e-01 0.043 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.056041e-01 0.043 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.056041e-01 0.043 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 9.066596e-01 0.043 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.094291e-01 0.041 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.094291e-01 0.041 0 0
Dual Incision in GG-NER R-HSA-5696400 9.110196e-01 0.040 0 0
Nuclear import of Rev protein R-HSA-180746 9.110196e-01 0.040 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.110196e-01 0.040 0 0
Gap junction assembly R-HSA-190861 9.110196e-01 0.040 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.110196e-01 0.040 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.110196e-01 0.040 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.110196e-01 0.040 0 0
Mitophagy R-HSA-5205647 9.110196e-01 0.040 0 0
Clathrin-mediated endocytosis R-HSA-8856828 9.119927e-01 0.040 0 0
Viral Messenger RNA Synthesis R-HSA-168325 9.136241e-01 0.039 0 0
Collagen degradation R-HSA-1442490 9.136241e-01 0.039 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 9.161247e-01 0.038 0 0
PERK regulates gene expression R-HSA-381042 9.161247e-01 0.038 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.161247e-01 0.038 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 9.161247e-01 0.038 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.176363e-01 0.037 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.201859e-01 0.036 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.209373e-01 0.036 0 0
RNA Polymerase III Transcription R-HSA-74158 9.209373e-01 0.036 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 9.209373e-01 0.036 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.209373e-01 0.036 0 0
Innate Immune System R-HSA-168249 9.237076e-01 0.034 1 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.254739e-01 0.034 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 9.254739e-01 0.034 0 0
NCAM1 interactions R-HSA-419037 9.254739e-01 0.034 0 0
Lysine catabolism R-HSA-71064 9.254739e-01 0.034 0 0
Collagen chain trimerization R-HSA-8948216 9.254739e-01 0.034 0 0
ER-Phagosome pathway R-HSA-1236974 9.278234e-01 0.033 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.280600e-01 0.032 0 0
MET promotes cell motility R-HSA-8875878 9.297505e-01 0.032 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 9.297505e-01 0.032 0 0
Elastic fibre formation R-HSA-1566948 9.297505e-01 0.032 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.297505e-01 0.032 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.319963e-01 0.031 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 9.337820e-01 0.030 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.337820e-01 0.030 0 0
RAS processing R-HSA-9648002 9.337820e-01 0.030 0 0
SARS-CoV Infections R-HSA-9679506 9.349571e-01 0.029 0 0
Metabolism of steroid hormones R-HSA-196071 9.351973e-01 0.029 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.366209e-01 0.028 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 9.375823e-01 0.028 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 9.375823e-01 0.028 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.375823e-01 0.028 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.375823e-01 0.028 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.375823e-01 0.028 0 0
Glycogen metabolism R-HSA-8982491 9.375823e-01 0.028 0 0
Generation of second messenger molecules R-HSA-202433 9.375823e-01 0.028 0 0
Leishmania infection R-HSA-9658195 9.400850e-01 0.027 0 0
Parasitic Infection Pathways R-HSA-9824443 9.400850e-01 0.027 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.411647e-01 0.026 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 9.411647e-01 0.026 0 0
Mitochondrial protein degradation R-HSA-9837999 9.440929e-01 0.025 0 0
Translation of Structural Proteins R-HSA-9683701 9.445418e-01 0.025 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.463959e-01 0.024 0 0
ECM proteoglycans R-HSA-3000178 9.466274e-01 0.024 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.466274e-01 0.024 0 0
Metabolism of cofactors R-HSA-8978934 9.466274e-01 0.024 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 9.477252e-01 0.023 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.487114e-01 0.023 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 9.491694e-01 0.023 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.491694e-01 0.023 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.494026e-01 0.023 0 0
Mitochondrial biogenesis R-HSA-1592230 9.495275e-01 0.022 0 0
Peptide hormone metabolism R-HSA-2980736 9.495275e-01 0.022 0 0
Ribosome-associated quality control R-HSA-9948299 9.501852e-01 0.022 0 0
Defensins R-HSA-1461973 9.507260e-01 0.022 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.507260e-01 0.022 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.508851e-01 0.022 1 0
Switching of origins to a post-replicative state R-HSA-69052 9.515956e-01 0.022 0 0
Gap junction trafficking R-HSA-190828 9.535547e-01 0.021 0 0
Disease R-HSA-1643685 9.546670e-01 0.020 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.561203e-01 0.019 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.562212e-01 0.019 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 9.562212e-01 0.019 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.562212e-01 0.019 0 0
Somitogenesis R-HSA-9824272 9.562212e-01 0.019 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.562212e-01 0.019 1 1
Degradation of cysteine and homocysteine R-HSA-1614558 9.562212e-01 0.019 0 0
Vesicle-mediated transport R-HSA-5653656 9.566485e-01 0.019 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.587348e-01 0.018 0 0
Regulation of TNFR1 signaling R-HSA-5357905 9.587348e-01 0.018 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 9.587348e-01 0.018 0 0
Translation of Structural Proteins R-HSA-9694635 9.602386e-01 0.018 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.611042e-01 0.017 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.611042e-01 0.017 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.611042e-01 0.017 0 0
Synthesis of PC R-HSA-1483191 9.611042e-01 0.017 0 0
PCP/CE pathway R-HSA-4086400 9.621561e-01 0.017 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 9.622218e-01 0.017 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.633377e-01 0.016 0 0
Metal ion SLC transporters R-HSA-425410 9.633377e-01 0.016 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.654431e-01 0.015 0 0
Signaling by MET R-HSA-6806834 9.657282e-01 0.015 0 0
RSV-host interactions R-HSA-9833110 9.669201e-01 0.015 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.692984e-01 0.014 0 0
Complex IV assembly R-HSA-9864848 9.692984e-01 0.014 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.692984e-01 0.014 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.696741e-01 0.013 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.696741e-01 0.013 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.702310e-01 0.013 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.710618e-01 0.013 0 0
Orc1 removal from chromatin R-HSA-68949 9.710618e-01 0.013 0 0
Synthesis of DNA R-HSA-69239 9.710632e-01 0.013 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.719242e-01 0.012 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.727240e-01 0.012 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 9.727240e-01 0.012 0 0
Extracellular matrix organization R-HSA-1474244 9.727865e-01 0.012 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.742908e-01 0.011 0 0
TCR signaling R-HSA-202403 9.747117e-01 0.011 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.757677e-01 0.011 0 0
TNF signaling R-HSA-75893 9.771598e-01 0.010 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.771598e-01 0.010 0 0
Digestion R-HSA-8935690 9.771598e-01 0.010 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.781616e-01 0.010 0 0
Neurotransmitter release cycle R-HSA-112310 9.802609e-01 0.009 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.802932e-01 0.009 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.808749e-01 0.008 0 0
rRNA processing R-HSA-72312 9.810771e-01 0.008 0 0
Glutathione conjugation R-HSA-156590 9.819739e-01 0.008 0 0
Selenoamino acid metabolism R-HSA-2408522 9.823033e-01 0.008 0 0
Parasite infection R-HSA-9664407 9.826411e-01 0.008 0 0
Leishmania phagocytosis R-HSA-9664417 9.826411e-01 0.008 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.826411e-01 0.008 0 0
Nucleotide salvage R-HSA-8956321 9.830099e-01 0.007 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.830475e-01 0.007 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.833631e-01 0.007 0 0
Mitochondrial protein import R-HSA-1268020 9.839863e-01 0.007 0 0
tRNA processing in the nucleus R-HSA-6784531 9.839863e-01 0.007 0 0
SLC transporter disorders R-HSA-5619102 9.842997e-01 0.007 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 9.847226e-01 0.007 0 0
Digestion and absorption R-HSA-8963743 9.849067e-01 0.007 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.857742e-01 0.006 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.865919e-01 0.006 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.868647e-01 0.006 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.876751e-01 0.005 0 0
Formation of the cornified envelope R-HSA-6809371 9.878568e-01 0.005 0 0
Host Interactions of HIV factors R-HSA-162909 9.878568e-01 0.005 0 0
Nicotinate metabolism R-HSA-196807 9.880892e-01 0.005 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.880892e-01 0.005 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.881448e-01 0.005 0 0
ABC-family proteins mediated transport R-HSA-382556 9.893030e-01 0.005 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.900278e-01 0.004 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.902003e-01 0.004 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.906012e-01 0.004 0 0
Retinoid metabolism and transport R-HSA-975634 9.906012e-01 0.004 0 0
Purine catabolism R-HSA-74259 9.911417e-01 0.004 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.917366e-01 0.004 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.924082e-01 0.003 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.925839e-01 0.003 0 0
ABC transporter disorders R-HSA-5619084 9.937915e-01 0.003 0 0
Cholesterol biosynthesis R-HSA-191273 9.937915e-01 0.003 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.941486e-01 0.003 0 0
Antimicrobial peptides R-HSA-6803157 9.942571e-01 0.003 0 0
Inositol phosphate metabolism R-HSA-1483249 9.945492e-01 0.002 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.948026e-01 0.002 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.953410e-01 0.002 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.953835e-01 0.002 1 1
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.958049e-01 0.002 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.958049e-01 0.002 0 0
Interferon alpha/beta signaling R-HSA-909733 9.958049e-01 0.002 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.961153e-01 0.002 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.961356e-01 0.002 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.963580e-01 0.002 0 0
Post-translational protein modification R-HSA-597592 9.964739e-01 0.002 0 0
Visual phototransduction R-HSA-2187338 9.966406e-01 0.001 0 0
Downstream TCR signaling R-HSA-202424 9.971270e-01 0.001 0 0
Protein localization R-HSA-9609507 9.974919e-01 0.001 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.976164e-01 0.001 0 0
FCGR activation R-HSA-2029481 9.977337e-01 0.001 0 0
Metabolism of steroids R-HSA-8957322 9.983841e-01 0.001 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.984336e-01 0.001 0 0
Infectious disease R-HSA-5663205 9.986552e-01 0.001 0 0
tRNA processing R-HSA-72306 9.989690e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.990245e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.992701e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.993483e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.995386e-01 0.000 0 0
Neddylation R-HSA-8951664 9.996236e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.996610e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.997327e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.998015e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.998181e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.998339e-01 0.000 0 0
Keratinization R-HSA-6805567 9.998420e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.998905e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.998922e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999310e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999359e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999686e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999697e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999712e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999907e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999940e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999941e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999943e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.999975e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999984e-01 0.000 0 0
Translation R-HSA-72766 9.999985e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999993e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999994e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999996e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999997e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.999998e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 1.000000e+00 0.000 1 1
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle, Mitotic R-HSA-69278 1.662499e-10 9.779 0 0
Cell Cycle R-HSA-1640170 1.411798e-10 9.850 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.108496e-09 8.386 0 0
Apoptotic execution phase R-HSA-75153 1.039464e-08 7.983 0 0
HSF1-dependent transactivation R-HSA-3371571 2.295827e-07 6.639 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.176746e-07 6.498 0 0
Axon guidance R-HSA-422475 4.504384e-07 6.346 0 0
Cell-Cell communication R-HSA-1500931 1.078842e-06 5.967 0 0
Attenuation phase R-HSA-3371568 1.018512e-06 5.992 0 0
Cellular response to heat stress R-HSA-3371556 1.227216e-06 5.911 0 0
Signaling by ERBB2 R-HSA-1227986 1.392989e-06 5.856 0 0
Nervous system development R-HSA-9675108 2.290268e-06 5.640 0 0
M Phase R-HSA-68886 2.452839e-06 5.610 0 0
mRNA Splicing - Major Pathway R-HSA-72163 4.229931e-06 5.374 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 5.220302e-06 5.282 0 0
Cell junction organization R-HSA-446728 1.370711e-05 4.863 0 0
mRNA Splicing R-HSA-72172 1.969104e-05 4.706 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.937550e-05 4.713 0 0
Signaling by EGFR R-HSA-177929 2.436550e-05 4.613 0 0
Striated Muscle Contraction R-HSA-390522 2.757263e-05 4.560 0 0
Adherens junctions interactions R-HSA-418990 3.742260e-05 4.427 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 4.124910e-05 4.385 0 0
Programmed Cell Death R-HSA-5357801 4.003385e-05 4.398 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 5.795399e-05 4.237 0 0
Signaling by ALK in cancer R-HSA-9700206 5.795399e-05 4.237 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 6.766322e-05 4.170 0 0
Apoptosis R-HSA-109581 6.801257e-05 4.167 0 0
Cell-cell junction organization R-HSA-421270 7.116408e-05 4.148 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.033349e-04 3.986 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.033349e-04 3.986 0 0
EPH-Ephrin signaling R-HSA-2682334 1.102543e-04 3.958 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.055476e-04 3.977 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.310223e-04 3.883 0 0
Cellular responses to stimuli R-HSA-8953897 1.331051e-04 3.876 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.487472e-04 3.828 0 0
Mitotic Anaphase R-HSA-68882 1.499340e-04 3.824 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.678624e-04 3.775 0 0
PECAM1 interactions R-HSA-210990 1.813026e-04 3.742 0 0
Regulation of CDH1 Function R-HSA-9764561 1.937992e-04 3.713 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.048246e-04 3.689 0 0
HSF1 activation R-HSA-3371511 2.066360e-04 3.685 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.100516e-04 3.678 0 0
Cell Cycle Checkpoints R-HSA-69620 2.444341e-04 3.612 0 0
Signal Transduction R-HSA-162582 2.575195e-04 3.589 0 0
Assembly of the pre-replicative complex R-HSA-68867 2.735124e-04 3.563 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 2.855558e-04 3.544 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.208782e-04 3.494 0 0
DNA Replication Pre-Initiation R-HSA-69002 3.231816e-04 3.491 0 0
L1CAM interactions R-HSA-373760 3.408956e-04 3.467 0 0
S Phase R-HSA-69242 3.703853e-04 3.431 0 0
Chromatin organization R-HSA-4839726 4.115692e-04 3.386 0 0
Cellular Senescence R-HSA-2559583 4.248638e-04 3.372 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 4.934432e-04 3.307 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 4.934432e-04 3.307 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 5.914043e-04 3.228 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 5.914043e-04 3.228 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 5.998823e-04 3.222 0 0
Chromatin modifying enzymes R-HSA-3247509 6.120395e-04 3.213 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 6.908357e-04 3.161 0 0
EPHB-mediated forward signaling R-HSA-3928662 7.992102e-04 3.097 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 8.002657e-04 3.097 0 0
mRNA 3'-end processing R-HSA-72187 8.346519e-04 3.078 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 9.169076e-04 3.038 0 0
G2/M Checkpoints R-HSA-69481 9.691195e-04 3.014 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.052817e-03 2.978 0 0
Long-term potentiation R-HSA-9620244 1.086797e-03 2.964 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.114257e-03 2.953 0 0
Cellular responses to stress R-HSA-2262752 1.076801e-03 2.968 0 0
Signaling by ALK R-HSA-201556 1.175927e-03 2.930 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.228084e-03 2.911 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.204936e-03 2.919 0 0
Regulation of KIT signaling R-HSA-1433559 1.229373e-03 2.910 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.233815e-03 2.909 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.244520e-03 2.905 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.318119e-03 2.880 0 0
ESR-mediated signaling R-HSA-8939211 1.281745e-03 2.892 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.340097e-03 2.873 0 0
RET signaling R-HSA-8853659 1.424285e-03 2.846 0 0
MAPK family signaling cascades R-HSA-5683057 1.482050e-03 2.829 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.421173e-03 2.847 0 0
DAP12 signaling R-HSA-2424491 1.607418e-03 2.794 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.607418e-03 2.794 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.946456e-03 2.711 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.942602e-03 2.712 0 0
Mitotic Prophase R-HSA-68875 1.959908e-03 2.708 0 0
Signaling by LTK R-HSA-9842663 1.946456e-03 2.711 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.942602e-03 2.712 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.881990e-03 2.725 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.999099e-03 2.699 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.999099e-03 2.699 0 0
Metabolism of RNA R-HSA-8953854 2.120481e-03 2.674 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.192975e-03 2.659 0 0
Signaling by ERBB4 R-HSA-1236394 2.283727e-03 2.641 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.322353e-03 2.634 0 0
Separation of Sister Chromatids R-HSA-2467813 2.352237e-03 2.629 0 0
Phosphorylation of the APC/C R-HSA-176412 2.617605e-03 2.582 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.617605e-03 2.582 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.482859e-03 2.605 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 2.575073e-03 2.589 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.648595e-03 2.577 0 0
Semaphorin interactions R-HSA-373755 3.052154e-03 2.515 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.246854e-03 2.489 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 3.432051e-03 2.464 0 0
HDACs deacetylate histones R-HSA-3214815 3.271901e-03 2.485 0 0
G2/M Transition R-HSA-69275 3.453294e-03 2.462 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.620876e-03 2.441 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.908100e-03 2.408 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 3.908100e-03 2.408 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.029122e-03 2.395 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 3.898598e-03 2.409 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 4.140584e-03 2.383 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 4.430197e-03 2.354 0 0
Mitotic Prometaphase R-HSA-68877 4.207836e-03 2.376 0 0
Intracellular signaling by second messengers R-HSA-9006925 4.367151e-03 2.360 0 0
FLT3 Signaling R-HSA-9607240 4.277387e-03 2.369 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 4.717811e-03 2.326 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 5.127578e-03 2.290 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 5.127578e-03 2.290 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 5.127578e-03 2.290 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 5.127578e-03 2.290 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 5.127578e-03 2.290 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 5.127578e-03 2.290 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 5.127578e-03 2.290 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 5.127578e-03 2.290 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 5.127578e-03 2.290 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 5.127578e-03 2.290 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 5.127578e-03 2.290 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.012654e-03 2.300 0 0
Meiotic synapsis R-HSA-1221632 4.802739e-03 2.319 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 4.802739e-03 2.319 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.802739e-03 2.319 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.456265e-03 2.263 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.456265e-03 2.263 0 0
Synthesis of DNA R-HSA-69239 5.103777e-03 2.292 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 5.695003e-03 2.245 0 0
Deubiquitination R-HSA-5688426 5.740482e-03 2.241 0 0
Cell-extracellular matrix interactions R-HSA-446353 5.880197e-03 2.231 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 6.126533e-03 2.213 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 6.159052e-03 2.210 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 6.718945e-03 2.173 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 6.404461e-03 2.194 0 0
Signaling by VEGF R-HSA-194138 6.646611e-03 2.177 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 6.425449e-03 2.192 0 0
Ephrin signaling R-HSA-3928664 6.789337e-03 2.168 0 0
GAB1 signalosome R-HSA-180292 6.789337e-03 2.168 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 6.789337e-03 2.168 0 0
Folding of actin by CCT/TriC R-HSA-390450 7.461009e-03 2.127 0 0
Signaling by PDGFR in disease R-HSA-9671555 7.405483e-03 2.130 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 7.405483e-03 2.130 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 7.405483e-03 2.130 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 7.405483e-03 2.130 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 7.487047e-03 2.126 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 7.461009e-03 2.127 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 7.461009e-03 2.127 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 7.328571e-03 2.135 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 7.159340e-03 2.145 0 0
Signaling by SCF-KIT R-HSA-1433557 7.566565e-03 2.121 0 0
Homology Directed Repair R-HSA-5693538 7.740098e-03 2.111 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 7.781053e-03 2.109 0 0
Sema4D in semaphorin signaling R-HSA-400685 7.781354e-03 2.109 0 0
G alpha (12/13) signalling events R-HSA-416482 7.831315e-03 2.106 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 7.837342e-03 2.106 0 0
Clathrin-mediated endocytosis R-HSA-8856828 8.072542e-03 2.093 0 0
Signaling by NTRKs R-HSA-166520 8.211149e-03 2.086 0 0
DNA Replication R-HSA-69306 8.337183e-03 2.079 0 0
G2/M DNA damage checkpoint R-HSA-69473 8.360711e-03 2.078 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 8.560019e-03 2.068 0 0
Post NMDA receptor activation events R-HSA-438064 8.845565e-03 2.053 0 0
Neutrophil degranulation R-HSA-6798695 9.277319e-03 2.033 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.013301e-02 1.994 0 0
Nuclear Envelope Breakdown R-HSA-2980766 9.217386e-03 2.035 0 0
PKMTs methylate histone lysines R-HSA-3214841 9.356420e-03 2.029 0 0
Degradation of CDH1 R-HSA-9766229 1.022762e-02 1.990 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.023234e-02 1.990 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.072118e-02 1.970 0 0
Meiosis R-HSA-1500620 1.075819e-02 1.968 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 1.080548e-02 1.966 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.080548e-02 1.966 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.080548e-02 1.966 0 0
MET activates PTPN11 R-HSA-8865999 1.097435e-02 1.960 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.207511e-02 1.918 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 1.207511e-02 1.918 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.163946e-02 1.934 0 0
Translation initiation complex formation R-HSA-72649 1.135717e-02 1.945 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.115368e-02 1.953 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.192141e-02 1.924 0 0
Nephrin family interactions R-HSA-373753 1.163946e-02 1.934 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.165605e-02 1.933 0 0
Signaling by PTK6 R-HSA-8848021 1.165605e-02 1.933 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.207511e-02 1.918 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.207511e-02 1.918 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.214836e-02 1.915 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.222053e-02 1.913 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.223489e-02 1.912 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.251861e-02 1.902 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.252722e-02 1.902 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.265065e-02 1.898 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.290846e-02 1.889 0 0
Signaling by FGFR4 in disease R-HSA-5655291 1.293005e-02 1.888 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.326110e-02 1.877 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.333450e-02 1.875 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 1.419860e-02 1.848 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 1.419860e-02 1.848 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.384609e-02 1.859 0 0
Recycling pathway of L1 R-HSA-437239 1.482390e-02 1.829 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 1.482390e-02 1.829 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.431495e-02 1.844 0 0
Signaling by Hippo R-HSA-2028269 1.419860e-02 1.848 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.445307e-02 1.840 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.514378e-02 1.820 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.472881e-02 1.832 0 0
Death Receptor Signaling R-HSA-73887 1.407192e-02 1.852 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.529090e-02 1.816 0 0
Regulation of TP53 Activity R-HSA-5633007 1.539469e-02 1.813 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.565227e-02 1.805 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.586991e-02 1.799 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.643448e-02 1.784 0 0
Centrosome maturation R-HSA-380287 1.714437e-02 1.766 0 0
G1/S Transition R-HSA-69206 1.717903e-02 1.765 0 0
GPVI-mediated activation cascade R-HSA-114604 1.718343e-02 1.765 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.718343e-02 1.765 0 0
Diseases of programmed cell death R-HSA-9645723 1.724134e-02 1.763 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 1.784994e-02 1.748 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.805842e-02 1.743 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.996682e-02 1.700 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.996682e-02 1.700 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.970051e-02 1.706 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.085728e-02 1.681 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 2.085728e-02 1.681 0 0
Pervasive developmental disorders R-HSA-9005895 2.085728e-02 1.681 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.085728e-02 1.681 0 0
Disorders of Nervous System Development R-HSA-9697154 2.085728e-02 1.681 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.873851e-02 1.727 0 0
Signaling by Erythropoietin R-HSA-9006335 1.838338e-02 1.736 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 1.838338e-02 1.736 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.087691e-02 1.680 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.087691e-02 1.680 0 0
DNA Double Strand Break Response R-HSA-5693606 1.989068e-02 1.701 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.863209e-02 1.730 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.863209e-02 1.730 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 1.873851e-02 1.727 0 0
DAP12 interactions R-HSA-2172127 1.833473e-02 1.737 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.087691e-02 1.680 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.121787e-02 1.673 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 2.137233e-02 1.670 0 0
Nucleosome assembly R-HSA-774815 2.137233e-02 1.670 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.210546e-02 1.656 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 2.222121e-02 1.653 0 0
Interleukin-37 signaling R-HSA-9008059 2.222121e-02 1.653 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.270798e-02 1.644 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.324798e-02 1.634 0 0
Regulation of signaling by CBL R-HSA-912631 2.324798e-02 1.634 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.324798e-02 1.634 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 2.329090e-02 1.633 0 0
Notch-HLH transcription pathway R-HSA-350054 2.329090e-02 1.633 0 0
Signaling by KIT in disease R-HSA-9669938 2.329090e-02 1.633 0 0
Signal attenuation R-HSA-74749 2.492806e-02 1.603 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 2.492806e-02 1.603 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.492806e-02 1.603 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 2.769535e-02 1.558 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 2.769535e-02 1.558 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.772870e-02 1.557 0 0
Packaging Of Telomere Ends R-HSA-171306 2.772870e-02 1.557 0 0
EGFR downregulation R-HSA-182971 2.662043e-02 1.575 0 0
Nuclear import of Rev protein R-HSA-180746 2.537147e-02 1.596 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 2.477699e-02 1.606 0 0
Signaling by RAS mutants R-HSA-6802949 2.477699e-02 1.606 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.477699e-02 1.606 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.477699e-02 1.606 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.477699e-02 1.606 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 2.825228e-02 1.549 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.747414e-02 1.561 0 0
Chromosome Maintenance R-HSA-73886 2.644036e-02 1.578 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.859203e-02 1.544 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.859203e-02 1.544 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.532273e-02 1.596 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.772870e-02 1.557 1 1
PIP3 activates AKT signaling R-HSA-1257604 2.858355e-02 1.544 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.620622e-02 1.582 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.769535e-02 1.558 0 0
NRAGE signals death through JNK R-HSA-193648 2.825228e-02 1.549 0 0
Disorders of Developmental Biology R-HSA-9675151 2.887907e-02 1.539 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 2.887907e-02 1.539 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.905520e-02 1.537 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 2.915657e-02 1.535 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.915657e-02 1.535 0 0
SOS-mediated signalling R-HSA-112412 2.915657e-02 1.535 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 2.915657e-02 1.535 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.990564e-02 1.524 0 0
Signaling by MET R-HSA-6806834 3.042787e-02 1.517 0 0
Signaling by FGFR4 R-HSA-5654743 3.062968e-02 1.514 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.116906e-02 1.506 0 0
G0 and Early G1 R-HSA-1538133 3.162166e-02 1.500 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.248555e-02 1.488 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 3.248555e-02 1.488 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 3.248555e-02 1.488 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.277889e-02 1.484 0 0
Interleukin-2 family signaling R-HSA-451927 3.277889e-02 1.484 0 0
Co-stimulation by CD28 R-HSA-389356 3.278424e-02 1.484 1 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 3.318708e-02 1.479 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 3.365297e-02 1.473 1 0
Processing of DNA double-strand break ends R-HSA-5693607 3.383015e-02 1.471 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.387951e-02 1.470 0 0
Host Interactions of HIV factors R-HSA-162909 3.414899e-02 1.467 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 3.469813e-02 1.460 0 0
Membrane Trafficking R-HSA-199991 3.508191e-02 1.455 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 3.580813e-02 1.446 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 3.580813e-02 1.446 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.581836e-02 1.446 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 3.591265e-02 1.445 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 3.591265e-02 1.445 0 0
Formation of annular gap junctions R-HSA-196025 4.106691e-02 1.387 0 0
Integrin signaling R-HSA-354192 3.726296e-02 1.429 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.726296e-02 1.429 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.726296e-02 1.429 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 4.357915e-02 1.361 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 4.068914e-02 1.391 0 0
Regulation of RAS by GAPs R-HSA-5658442 4.254117e-02 1.371 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.041111e-02 1.393 0 0
Signaling by FGFR3 R-HSA-5654741 4.041111e-02 1.393 0 0
Regulation of necroptotic cell death R-HSA-5675482 3.726296e-02 1.429 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 4.019577e-02 1.396 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.996688e-02 1.398 0 0
DAG and IP3 signaling R-HSA-1489509 4.041111e-02 1.393 0 0
Uptake and function of anthrax toxins R-HSA-5210891 3.634191e-02 1.440 0 0
TCF dependent signaling in response to WNT R-HSA-201681 4.277443e-02 1.369 0 0
Signaling by FGFR1 in disease R-HSA-5655302 4.359943e-02 1.361 0 0
PTEN Regulation R-HSA-6807070 4.294951e-02 1.367 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 3.791395e-02 1.421 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 3.949736e-02 1.403 0 0
Signaling by NOTCH4 R-HSA-9013694 4.431651e-02 1.353 0 0
Signaling by NOTCH R-HSA-157118 4.466896e-02 1.350 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.468159e-02 1.350 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 4.468159e-02 1.350 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 4.500409e-02 1.347 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 4.559582e-02 1.341 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 4.559582e-02 1.341 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 4.559582e-02 1.341 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 4.574623e-02 1.340 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.574623e-02 1.340 0 0
Diseases of Telomere Maintenance R-HSA-9673013 4.590236e-02 1.338 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 4.590236e-02 1.338 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 4.590236e-02 1.338 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 4.590236e-02 1.338 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 4.590236e-02 1.338 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 4.590236e-02 1.338 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.625846e-02 1.335 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 4.724409e-02 1.326 0 0
Meiotic recombination R-HSA-912446 4.812821e-02 1.318 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 4.871375e-02 1.312 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 4.871375e-02 1.312 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 4.871375e-02 1.312 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.977410e-02 1.303 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 4.985756e-02 1.302 0 0
MTOR signalling R-HSA-165159 4.985958e-02 1.302 0 0
Signaling by Interleukins R-HSA-449147 5.005623e-02 1.301 0 0
Inhibition of nitric oxide production R-HSA-9636249 5.434844e-02 1.265 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 5.434844e-02 1.265 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 5.434844e-02 1.265 0 0
Gap junction degradation R-HSA-190873 5.553369e-02 1.255 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.741059e-02 1.241 0 0
Repression of WNT target genes R-HSA-4641265 5.741059e-02 1.241 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 5.741059e-02 1.241 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 5.680810e-02 1.246 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 5.680810e-02 1.246 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 5.492028e-02 1.260 0 0
mTORC1-mediated signalling R-HSA-166208 5.237328e-02 1.281 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 6.227110e-02 1.206 0 0
Interleukin receptor SHC signaling R-HSA-912526 6.227110e-02 1.206 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 5.835591e-02 1.234 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 5.835591e-02 1.234 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 5.835591e-02 1.234 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 6.080997e-02 1.216 0 0
AURKA Activation by TPX2 R-HSA-8854518 5.247115e-02 1.280 0 0
Telomere Maintenance R-HSA-157579 5.125364e-02 1.290 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 5.910791e-02 1.228 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 5.910791e-02 1.228 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 5.910791e-02 1.228 0 0
GP1b-IX-V activation signalling R-HSA-430116 5.553369e-02 1.255 0 0
Syndecan interactions R-HSA-3000170 6.227110e-02 1.206 0 0
Neurexins and neuroligins R-HSA-6794361 5.421243e-02 1.266 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 6.158117e-02 1.211 0 0
Unwinding of DNA R-HSA-176974 5.553369e-02 1.255 0 0
Gene Silencing by RNA R-HSA-211000 5.577621e-02 1.254 0 0
Signaling by WNT R-HSA-195721 5.793078e-02 1.237 0 0
Ub-specific processing proteases R-HSA-5689880 6.081977e-02 1.216 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.064361e-02 1.217 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 5.553369e-02 1.255 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 6.158117e-02 1.211 0 0
Orc1 removal from chromatin R-HSA-68949 5.421243e-02 1.266 0 0
Reproduction R-HSA-1474165 6.300614e-02 1.201 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 6.306061e-02 1.200 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 5.060125e-02 1.296 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 6.345235e-02 1.198 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 6.345235e-02 1.198 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 6.503824e-02 1.187 0 0
IRE1alpha activates chaperones R-HSA-381070 6.607119e-02 1.180 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 6.612901e-02 1.180 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 6.612901e-02 1.180 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 6.612901e-02 1.180 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 6.612901e-02 1.180 0 0
PRC2 methylates histones and DNA R-HSA-212300 6.686498e-02 1.175 0 0
CaM pathway R-HSA-111997 6.686498e-02 1.175 0 0
Calmodulin induced events R-HSA-111933 6.686498e-02 1.175 0 0
FLT3 signaling in disease R-HSA-9682385 6.686498e-02 1.175 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 6.805241e-02 1.167 0 0
Nef and signal transduction R-HSA-164944 6.865392e-02 1.163 0 0
HIV Infection R-HSA-162906 6.956848e-02 1.158 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 6.958768e-02 1.157 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 6.989393e-02 1.156 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 6.989393e-02 1.156 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 6.989393e-02 1.156 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 7.161789e-02 1.145 1 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 7.210121e-02 1.142 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 7.210121e-02 1.142 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 7.210121e-02 1.142 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 7.210121e-02 1.142 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 7.258164e-02 1.139 0 0
PI3K/AKT activation R-HSA-198203 7.258164e-02 1.139 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 7.259215e-02 1.139 0 0
G-protein beta:gamma signalling R-HSA-397795 7.259215e-02 1.139 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 7.259215e-02 1.139 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 7.259215e-02 1.139 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 7.259215e-02 1.139 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 7.259215e-02 1.139 0 0
Deadenylation of mRNA R-HSA-429947 7.328386e-02 1.135 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 7.328386e-02 1.135 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 7.328386e-02 1.135 0 0
Neurodegenerative Diseases R-HSA-8863678 7.328386e-02 1.135 0 0
Signaling by ROBO receptors R-HSA-376176 7.547221e-02 1.122 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 7.745129e-02 1.111 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 7.797156e-02 1.108 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 7.797156e-02 1.108 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 7.839843e-02 1.106 0 0
PKR-mediated signaling R-HSA-9833482 7.839843e-02 1.106 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 7.841341e-02 1.106 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 7.865181e-02 1.104 0 0
DNA methylation R-HSA-5334118 7.877914e-02 1.104 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 7.890751e-02 1.103 0 0
IKBKB deficiency causes SCID R-HSA-5602636 9.263858e-02 1.033 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 9.263858e-02 1.033 0 0
Regulation of gap junction activity R-HSA-191650 8.324927e-02 1.080 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 8.324927e-02 1.080 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 8.324927e-02 1.080 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 8.324927e-02 1.080 0 0
MECP2 regulates transcription factors R-HSA-9022707 9.215515e-02 1.035 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 9.215515e-02 1.035 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 9.215515e-02 1.035 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 9.215515e-02 1.035 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 9.216300e-02 1.035 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 9.216300e-02 1.035 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 9.216300e-02 1.035 0 0
CRMPs in Sema3A signaling R-HSA-399956 8.874708e-02 1.052 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.874708e-02 1.052 0 0
Erythropoietin activates RAS R-HSA-9027284 1.073028e-01 0.969 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.073028e-01 0.969 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 1.073028e-01 0.969 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 1.073028e-01 0.969 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.073028e-01 0.969 0 0
SHC1 events in EGFR signaling R-HSA-180336 1.073028e-01 0.969 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.073028e-01 0.969 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 9.249284e-02 1.034 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 9.869521e-02 1.006 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 9.869521e-02 1.006 0 0
Activation of the pre-replicative complex R-HSA-68962 9.049295e-02 1.043 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 9.049295e-02 1.043 0 0
Trafficking of AMPA receptors R-HSA-399719 1.031936e-01 0.986 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.031936e-01 0.986 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.031936e-01 0.986 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.427099e-02 1.026 0 0
Amplification of signal from the kinetochores R-HSA-141424 8.518728e-02 1.070 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 8.518728e-02 1.070 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 8.482130e-02 1.071 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.998046e-02 1.000 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 9.516437e-02 1.022 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 8.620735e-02 1.064 0 0
Protein folding R-HSA-391251 1.068757e-01 0.971 0 0
Downstream signal transduction R-HSA-186763 1.031936e-01 0.986 0 0
UCH proteinases R-HSA-5689603 8.552467e-02 1.068 0 0
Signaling by FGFR1 R-HSA-5654736 8.381046e-02 1.077 0 0
TNF signaling R-HSA-75893 8.381046e-02 1.077 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 8.542924e-02 1.068 0 0
Resolution of D-Loop Structures R-HSA-5693537 8.299336e-02 1.081 0 0
CHL1 interactions R-HSA-447041 9.215515e-02 1.035 0 0
Chaperone Mediated Autophagy R-HSA-9613829 9.987343e-02 1.001 0 0
Myogenesis R-HSA-525793 9.869521e-02 1.006 0 0
TBC/RABGAPs R-HSA-8854214 9.906947e-02 1.004 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 8.324927e-02 1.080 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.042380e-02 1.044 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.310674e-02 1.031 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 9.987343e-02 1.001 0 0
Defective pyroptosis R-HSA-9710421 9.906947e-02 1.004 0 0
Gene expression (Transcription) R-HSA-74160 8.671296e-02 1.062 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 9.869521e-02 1.006 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 9.215515e-02 1.035 0 0
Formation of paraxial mesoderm R-HSA-9793380 8.463337e-02 1.072 0 0
Smooth Muscle Contraction R-HSA-445355 1.013826e-01 0.994 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 8.324927e-02 1.080 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 9.239135e-02 1.034 0 0
Tie2 Signaling R-HSA-210993 9.987343e-02 1.001 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 9.987343e-02 1.001 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.031936e-01 0.986 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 8.103118e-02 1.091 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 1.102223e-01 0.958 0 0
Proteasome assembly R-HSA-9907900 1.102223e-01 0.958 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.111708e-01 0.954 0 0
IGF1R signaling cascade R-HSA-2428924 1.116140e-01 0.952 0 0
Metabolism of non-coding RNA R-HSA-194441 1.117846e-01 0.952 0 0
snRNP Assembly R-HSA-191859 1.117846e-01 0.952 0 0
Co-inhibition by PD-1 R-HSA-389948 1.122964e-01 0.950 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.130832e-01 0.947 0 0
Signaling by FGFR3 in disease R-HSA-5655332 1.130832e-01 0.947 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.130832e-01 0.947 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.141654e-01 0.942 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.141654e-01 0.942 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 1.141654e-01 0.942 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.141654e-01 0.942 0 0
DNA strand elongation R-HSA-69190 1.168713e-01 0.932 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 1.173295e-01 0.931 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 1.173295e-01 0.931 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.173309e-01 0.931 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.173309e-01 0.931 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 1.173309e-01 0.931 0 0
IRS activation R-HSA-74713 1.173309e-01 0.931 0 0
G2 Phase R-HSA-68911 1.173309e-01 0.931 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 1.173309e-01 0.931 0 0
NrCAM interactions R-HSA-447038 1.173309e-01 0.931 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.189449e-01 0.925 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.189449e-01 0.925 0 0
Regulation by c-FLIP R-HSA-3371378 1.189449e-01 0.925 0 0
Dimerization of procaspase-8 R-HSA-69416 1.189449e-01 0.925 0 0
MET receptor recycling R-HSA-8875656 1.189449e-01 0.925 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 1.189449e-01 0.925 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 1.189449e-01 0.925 0 0
RUNX2 regulates bone development R-HSA-8941326 1.194459e-01 0.923 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.199029e-01 0.921 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.199029e-01 0.921 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.208597e-01 0.918 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 1.216476e-01 0.915 0 0
Somitogenesis R-HSA-9824272 1.220846e-01 0.913 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 1.240607e-01 0.906 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 1.276873e-01 0.894 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 1.276873e-01 0.894 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.276873e-01 0.894 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.557888e-01 0.807 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.557888e-01 0.807 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.557888e-01 0.807 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 1.557888e-01 0.807 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.557888e-01 0.807 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.557888e-01 0.807 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.557888e-01 0.807 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.557888e-01 0.807 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.557888e-01 0.807 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 1.479708e-01 0.830 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.479708e-01 0.830 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.556449e-01 0.808 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.556449e-01 0.808 0 0
Phosphorylation of Emi1 R-HSA-176417 1.556449e-01 0.808 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.486612e-01 0.828 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 1.486612e-01 0.828 0 0
Calcineurin activates NFAT R-HSA-2025928 1.486612e-01 0.828 0 0
CASP8 activity is inhibited R-HSA-5218900 1.486612e-01 0.828 0 0
ALK mutants bind TKIs R-HSA-9700645 1.486612e-01 0.828 0 0
MET activates RAS signaling R-HSA-8851805 1.384217e-01 0.859 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.384217e-01 0.859 0 0
GRB2 events in EGFR signaling R-HSA-179812 1.384217e-01 0.859 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.384217e-01 0.859 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.384217e-01 0.859 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.384217e-01 0.859 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.384217e-01 0.859 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.808822e-01 0.743 0 0
MAPK3 (ERK1) activation R-HSA-110056 1.808822e-01 0.743 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.808822e-01 0.743 0 0
2-LTR circle formation R-HSA-164843 1.808822e-01 0.743 0 0
Negative regulation of MET activity R-HSA-6807004 1.362552e-01 0.866 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 1.362552e-01 0.866 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.734658e-01 0.761 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 1.417121e-01 0.849 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.605334e-01 0.794 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 1.605334e-01 0.794 0 0
Late endosomal microautophagy R-HSA-9615710 1.451056e-01 0.838 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.451056e-01 0.838 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.315071e-01 0.881 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.333201e-01 0.875 0 0
Degradation of DVL R-HSA-4641258 1.333201e-01 0.875 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.470734e-01 0.832 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 1.342979e-01 0.872 0 0
MET promotes cell motility R-HSA-8875878 1.480249e-01 0.830 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.635337e-01 0.786 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.482348e-01 0.829 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.635313e-01 0.786 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 1.808441e-01 0.743 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.603761e-01 0.795 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.361450e-01 0.866 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.793849e-01 0.746 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 1.745241e-01 0.758 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.613876e-01 0.792 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.613876e-01 0.792 0 0
Signaling by FGFR2 R-HSA-5654738 1.731275e-01 0.762 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.605334e-01 0.794 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.605334e-01 0.794 0 0
Signalling to ERKs R-HSA-187687 1.808441e-01 0.743 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 1.804514e-01 0.744 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.675221e-01 0.776 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 1.474461e-01 0.831 0 0
G1 Phase R-HSA-69236 1.782619e-01 0.749 0 0
Cyclin D associated events in G1 R-HSA-69231 1.782619e-01 0.749 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.346466e-01 0.871 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.527035e-01 0.816 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 1.635313e-01 0.786 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.923672e-01 0.716 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.675221e-01 0.776 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.315071e-01 0.881 0 0
G-protein mediated events R-HSA-112040 1.432553e-01 0.844 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 1.808822e-01 0.743 0 0
Regulation of CDH11 function R-HSA-9762292 1.808822e-01 0.743 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.470734e-01 0.832 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.345144e-01 0.871 0 0
Opioid Signalling R-HSA-111885 1.780508e-01 0.749 0 0
RNA Polymerase I Transcription R-HSA-73864 1.505197e-01 0.822 0 0
PLC beta mediated events R-HSA-112043 1.332171e-01 0.875 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.635337e-01 0.786 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.359726e-01 0.867 0 0
Interleukin-6 signaling R-HSA-1059683 1.647207e-01 0.783 0 0
Ca-dependent events R-HSA-111996 1.482348e-01 0.829 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.431942e-01 0.844 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.431942e-01 0.844 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.368454e-01 0.864 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.368454e-01 0.864 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 1.384217e-01 0.859 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.384217e-01 0.859 0 0
HDMs demethylate histones R-HSA-3214842 1.605334e-01 0.794 0 0
Hedgehog 'on' state R-HSA-5632684 1.923672e-01 0.716 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.480249e-01 0.830 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.886898e-01 0.724 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.457612e-01 0.836 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 1.556449e-01 0.808 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.333201e-01 0.875 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.635337e-01 0.786 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.855924e-01 0.731 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.855924e-01 0.731 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.855924e-01 0.731 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.855924e-01 0.731 0 0
HATs acetylate histones R-HSA-3214847 1.302576e-01 0.885 0 0
Circadian clock R-HSA-9909396 1.845748e-01 0.734 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.579222e-01 0.802 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.451056e-01 0.838 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.315071e-01 0.881 0 0
Amyloid fiber formation R-HSA-977225 1.850608e-01 0.733 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.384217e-01 0.859 0 0
Regulation of Apoptosis R-HSA-169911 1.808441e-01 0.743 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.577340e-01 0.802 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.618071e-01 0.791 0 0
NGF-stimulated transcription R-HSA-9031628 1.618071e-01 0.791 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 1.798041e-01 0.745 0 0
Signaling by NOTCH1 R-HSA-1980143 1.296591e-01 0.887 0 0
Muscle contraction R-HSA-397014 1.588354e-01 0.799 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.479708e-01 0.830 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.635337e-01 0.786 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.811683e-01 0.742 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 1.798041e-01 0.745 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.565701e-01 0.805 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.315071e-01 0.881 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.447534e-01 0.839 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.855924e-01 0.731 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.470734e-01 0.832 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.550047e-01 0.810 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.635313e-01 0.786 0 0
Specification of primordial germ cells R-HSA-9827857 1.734658e-01 0.761 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.497881e-01 0.825 0 0
Signaling by Leptin R-HSA-2586552 1.808822e-01 0.743 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.836421e-01 0.736 0 0
SARS-CoV Infections R-HSA-9679506 1.301044e-01 0.886 0 0
Cleavage of the damaged purine R-HSA-110331 1.333201e-01 0.875 0 0
Depurination R-HSA-73927 1.480249e-01 0.830 0 0
Interleukin-12 signaling R-HSA-9020591 1.886898e-01 0.724 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.482348e-01 0.829 0 0
Depyrimidination R-HSA-73928 1.482348e-01 0.829 0 0
Removal of the Flap Intermediate R-HSA-69166 1.928179e-01 0.715 0 0
Retrograde neurotrophin signalling R-HSA-177504 1.928179e-01 0.715 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 1.928179e-01 0.715 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 1.968022e-01 0.706 1 1
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.968022e-01 0.706 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 1.968022e-01 0.706 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 1.968022e-01 0.706 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 1.971995e-01 0.705 0 0
Signaling by LTK in cancer R-HSA-9842640 1.971995e-01 0.705 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 1.971995e-01 0.705 0 0
G2/M DNA replication checkpoint R-HSA-69478 1.971995e-01 0.705 0 0
Autointegration results in viral DNA circles R-HSA-177539 1.971995e-01 0.705 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 1.971995e-01 0.705 0 0
Neurofascin interactions R-HSA-447043 1.971995e-01 0.705 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.971995e-01 0.705 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 1.971995e-01 0.705 0 0
Synaptic adhesion-like molecules R-HSA-8849932 1.985598e-01 0.702 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 2.005694e-01 0.698 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 2.009581e-01 0.697 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 2.009581e-01 0.697 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.035679e-01 0.691 0 0
Interleukin-12 family signaling R-HSA-447115 2.055647e-01 0.687 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.057905e-01 0.687 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.057905e-01 0.687 0 0
TRKA activation by NGF R-HSA-187042 2.080885e-01 0.682 0 0
PLC-gamma1 signalling R-HSA-167021 2.080885e-01 0.682 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.101244e-01 0.678 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.109453e-01 0.676 0 0
MAP2K and MAPK activation R-HSA-5674135 2.144793e-01 0.669 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 2.144793e-01 0.669 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 2.144793e-01 0.669 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.145428e-01 0.668 0 0
Signaling by APC mutants R-HSA-4839744 2.151527e-01 0.667 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.151527e-01 0.667 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.151527e-01 0.667 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.151527e-01 0.667 0 0
Interleukin-2 signaling R-HSA-9020558 2.151527e-01 0.667 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.151527e-01 0.667 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 2.178043e-01 0.662 0 0
Potential therapeutics for SARS R-HSA-9679191 2.187398e-01 0.660 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.190368e-01 0.659 0 0
MGMT-mediated DNA damage reversal R-HSA-5657655 2.873150e-01 0.542 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.873150e-01 0.542 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.873150e-01 0.542 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 2.873150e-01 0.542 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.873150e-01 0.542 0 0
Hereditary fructose intolerance R-HSA-5657560 2.873150e-01 0.542 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 2.873150e-01 0.542 0 0
SARS-CoV-1 targets PDZ proteins in cell-cell junction R-HSA-9692912 2.873150e-01 0.542 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 2.873150e-01 0.542 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.873150e-01 0.542 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.701589e-01 0.568 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 2.701589e-01 0.568 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.701589e-01 0.568 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 2.701589e-01 0.568 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 2.701589e-01 0.568 0 0
Nef mediated downregulation of CD28 cell surface expression R-HSA-164939 3.983560e-01 0.400 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 3.983560e-01 0.400 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 3.983560e-01 0.400 0 0
Defective SLC9A9 causes autism 16 (AUTS16) R-HSA-5619052 3.983560e-01 0.400 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.983560e-01 0.400 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.983560e-01 0.400 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 3.983560e-01 0.400 0 0
Defective VWF binding to collagen type I R-HSA-9845622 3.983560e-01 0.400 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.983560e-01 0.400 0 0
Defective TPMT causes TPMT deficiency R-HSA-5578995 3.983560e-01 0.400 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.983560e-01 0.400 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.983560e-01 0.400 0 0
TRIF-mediated programmed cell death R-HSA-2562578 2.410298e-01 0.618 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 3.321155e-01 0.479 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 3.321155e-01 0.479 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 3.321155e-01 0.479 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 3.321155e-01 0.479 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 2.862407e-01 0.543 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 2.862407e-01 0.543 0 0
Activation of RAC1 R-HSA-428540 2.510066e-01 0.600 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.224460e-01 0.653 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.224460e-01 0.653 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 2.224460e-01 0.653 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 2.248932e-01 0.648 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 2.879841e-01 0.541 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.879841e-01 0.541 0 0
Polymerase switching R-HSA-69091 2.879841e-01 0.541 0 0
Leading Strand Synthesis R-HSA-69109 2.879841e-01 0.541 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 2.879841e-01 0.541 0 0
Scavenging by Class F Receptors R-HSA-3000484 2.879841e-01 0.541 0 0
WNT mediated activation of DVL R-HSA-201688 3.320330e-01 0.479 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 3.320330e-01 0.479 0 0
TRAIL signaling R-HSA-75158 3.924875e-01 0.406 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 3.924875e-01 0.406 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 3.924875e-01 0.406 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 3.924875e-01 0.406 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 3.924875e-01 0.406 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 3.924875e-01 0.406 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 3.924875e-01 0.406 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 3.924875e-01 0.406 0 0
Signaling by MAPK mutants R-HSA-9652817 3.924875e-01 0.406 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.522776e-01 0.598 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.495404e-01 0.603 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 2.805184e-01 0.552 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 3.777143e-01 0.423 0 0
DNA replication initiation R-HSA-68952 3.777143e-01 0.423 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 3.777143e-01 0.423 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 3.176997e-01 0.498 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.176997e-01 0.498 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 2.750632e-01 0.561 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 2.750632e-01 0.561 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 3.094190e-01 0.509 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 3.094190e-01 0.509 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 3.635832e-01 0.439 0 0
MET activates PTK2 signaling R-HSA-8874081 3.012147e-01 0.521 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 2.574738e-01 0.589 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 3.506422e-01 0.455 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 3.506422e-01 0.455 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 3.387845e-01 0.470 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 4.227028e-01 0.374 0 0
Aggrephagy R-HSA-9646399 2.781539e-01 0.556 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 4.014245e-01 0.396 0 0
G beta:gamma signalling through BTK R-HSA-8964315 4.014245e-01 0.396 0 0
E2F mediated regulation of DNA replication R-HSA-113510 3.837393e-01 0.416 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 3.837393e-01 0.416 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 2.908996e-01 0.536 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 3.548194e-01 0.450 0 0
Telomere Extension By Telomerase R-HSA-171319 3.548194e-01 0.450 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 3.548194e-01 0.450 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.338249e-01 0.631 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 3.214753e-01 0.493 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 3.675954e-01 0.435 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 3.819858e-01 0.418 0 0
Thromboxane signalling through TP receptor R-HSA-428930 3.981605e-01 0.400 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 3.981605e-01 0.400 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 4.167515e-01 0.380 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 4.167515e-01 0.380 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 4.388397e-01 0.358 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 3.114361e-01 0.507 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 3.928186e-01 0.406 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 4.278185e-01 0.369 0 0
Tight junction interactions R-HSA-420029 4.278185e-01 0.369 0 0
Post-translational protein phosphorylation R-HSA-8957275 3.900435e-01 0.409 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 4.371117e-01 0.359 0 0
Formation of a pool of free 40S subunits R-HSA-72689 4.331361e-01 0.363 0 0
Extension of Telomeres R-HSA-180786 2.513932e-01 0.600 0 0
Signaling by FGFR R-HSA-190236 3.900435e-01 0.409 0 0
Insulin receptor signalling cascade R-HSA-74751 3.387995e-01 0.470 0 0
DARPP-32 events R-HSA-180024 3.819858e-01 0.418 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.092113e-01 0.388 0 0
Signalling to RAS R-HSA-167044 2.805184e-01 0.552 0 0
Ribosome-associated quality control R-HSA-9948299 3.914891e-01 0.407 0 0
Prolonged ERK activation events R-HSA-169893 2.533248e-01 0.596 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 2.908996e-01 0.536 1 1
Activation of SMO R-HSA-5635838 4.388397e-01 0.358 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 3.316960e-01 0.479 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 4.278185e-01 0.369 0 0
Hedgehog 'off' state R-HSA-5610787 4.208875e-01 0.376 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 3.176997e-01 0.498 0 0
Polo-like kinase mediated events R-HSA-156711 3.506422e-01 0.455 0 0
Integration of provirus R-HSA-162592 2.510066e-01 0.600 0 0
Processive synthesis on the lagging strand R-HSA-69183 2.224460e-01 0.653 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 2.851699e-01 0.545 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 2.908996e-01 0.536 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 3.214753e-01 0.493 0 0
Frs2-mediated activation R-HSA-170968 3.256459e-01 0.487 0 0
DCC mediated attractive signaling R-HSA-418885 2.224460e-01 0.653 0 0
CD28 dependent Vav1 pathway R-HSA-389359 3.256459e-01 0.487 0 0
Josephin domain DUBs R-HSA-5689877 3.777143e-01 0.423 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 3.176997e-01 0.498 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 2.853986e-01 0.545 0 0
Mitochondrial biogenesis R-HSA-1592230 3.015385e-01 0.521 0 0
Interleukin-15 signaling R-HSA-8983432 2.879841e-01 0.541 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 2.533248e-01 0.596 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.851699e-01 0.545 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 2.851699e-01 0.545 0 0
Adipogenesis R-HSA-9843745 4.386150e-01 0.358 0 0
Ca2+ pathway R-HSA-4086398 3.026540e-01 0.519 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 2.459247e-01 0.609 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 2.410298e-01 0.618 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 2.410298e-01 0.618 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.224460e-01 0.653 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 3.924875e-01 0.406 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 2.851699e-01 0.545 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 3.635832e-01 0.439 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.513932e-01 0.600 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.167515e-01 0.380 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 3.638330e-01 0.439 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.913478e-01 0.407 0 0
Protein ubiquitination R-HSA-8852135 2.484949e-01 0.605 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 2.410298e-01 0.618 0 0
IRS-mediated signalling R-HSA-112399 4.216393e-01 0.375 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 2.283657e-01 0.641 0 0
Ion homeostasis R-HSA-5578775 2.934884e-01 0.532 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 3.966609e-01 0.402 1 0
Sodium/Proton exchangers R-HSA-425986 2.862407e-01 0.543 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 2.247914e-01 0.648 0 0
TGFBR3 expression R-HSA-9839394 2.750632e-01 0.561 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.235919e-01 0.651 0 0
Telomere C-strand synthesis initiation R-HSA-174430 4.014245e-01 0.396 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.424582e-01 0.615 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 3.020460e-01 0.520 0 0
COPI-mediated anterograde transport R-HSA-6807878 2.784247e-01 0.555 0 0
Signaling by PDGF R-HSA-186797 4.073413e-01 0.390 0 0
Laminin interactions R-HSA-3000157 4.278185e-01 0.369 0 0
Signaling by NOTCH3 R-HSA-9012852 3.811942e-01 0.419 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 3.278484e-01 0.484 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.312509e-01 0.480 0 0
TCR signaling R-HSA-202403 2.580903e-01 0.588 0 0
PCP/CE pathway R-HSA-4086400 2.943334e-01 0.531 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.544113e-01 0.594 0 0
Activation and oligomerization of BAK protein R-HSA-111452 2.873150e-01 0.542 0 0
Signaling by FGFR in disease R-HSA-1226099 2.338774e-01 0.631 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.338249e-01 0.631 0 0
Cellular response to hypoxia R-HSA-1234174 3.570686e-01 0.447 0 0
HIV Life Cycle R-HSA-162587 2.909337e-01 0.536 0 0
Interleukin-6 family signaling R-HSA-6783589 3.981605e-01 0.400 0 0
Signaling by FGFR2 in disease R-HSA-5655253 2.829484e-01 0.548 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.981605e-01 0.400 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 3.981605e-01 0.400 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 3.527127e-01 0.453 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 2.701589e-01 0.568 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.207894e-01 0.656 0 0
RNA Polymerase II Transcription R-HSA-73857 3.060772e-01 0.514 0 0
MAP kinase activation R-HSA-450294 3.879779e-01 0.411 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 3.387845e-01 0.470 0 0
Unfolded Protein Response (UPR) R-HSA-381119 2.666676e-01 0.574 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 2.516621e-01 0.599 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 2.400372e-01 0.620 0 0
DNA Repair R-HSA-73894 3.861046e-01 0.413 0 0
Regulated Necrosis R-HSA-5218859 2.246057e-01 0.649 0 0
Netrin-1 signaling R-HSA-373752 3.870158e-01 0.412 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.900435e-01 0.409 0 0
Degradation of CRY and PER proteins R-HSA-9932298 3.208357e-01 0.494 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.900435e-01 0.409 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.900435e-01 0.409 0 0
Interleukin-1 signaling R-HSA-9020702 3.496504e-01 0.456 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 2.713603e-01 0.566 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.400372e-01 0.620 0 0
NCAM signaling for neurite out-growth R-HSA-375165 4.073413e-01 0.390 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 2.873150e-01 0.542 0 0
MTF1 activates gene expression R-HSA-5660489 2.701589e-01 0.568 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.983560e-01 0.400 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.983560e-01 0.400 0 0
Transport of connexins along the secretory pathway R-HSA-190827 3.983560e-01 0.400 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.983560e-01 0.400 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 3.321155e-01 0.479 0 0
Co-inhibition by BTLA R-HSA-9927353 3.321155e-01 0.479 0 0
Reelin signalling pathway R-HSA-8866376 3.321155e-01 0.479 0 0
Co-stimulation by ICOS R-HSA-9927354 2.862407e-01 0.543 0 0
Signaling by AXIN mutants R-HSA-4839735 2.510066e-01 0.600 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 3.320330e-01 0.479 0 0
Proton/oligopeptide cotransporters R-HSA-427975 3.924875e-01 0.406 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 2.232301e-01 0.651 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 3.777143e-01 0.423 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 2.373336e-01 0.625 0 0
RAF activation R-HSA-5673000 2.633648e-01 0.579 0 0
Presynaptic function of Kainate receptors R-HSA-500657 3.506422e-01 0.455 0 0
Bicarbonate transporters R-HSA-425381 4.227028e-01 0.374 0 0
Ionotropic activity of kainate receptors R-HSA-451306 4.227028e-01 0.374 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 2.297235e-01 0.639 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 2.992998e-01 0.524 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 2.908996e-01 0.536 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 3.306225e-01 0.481 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 2.384453e-01 0.623 0 0
Budding and maturation of HIV virion R-HSA-162588 4.363660e-01 0.360 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 3.882117e-01 0.411 0 0
Heme signaling R-HSA-9707616 4.073413e-01 0.390 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 2.805184e-01 0.552 0 0
Cytokine Signaling in Immune system R-HSA-1280215 2.206023e-01 0.656 1 0
Downstream TCR signaling R-HSA-202424 2.443164e-01 0.612 0 0
Signal transduction by L1 R-HSA-445144 2.522776e-01 0.598 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.425167e-01 0.465 0 0
Signaling by TGFBR3 R-HSA-9839373 4.316887e-01 0.365 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 2.787504e-01 0.555 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.379138e-01 0.624 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.855477e-01 0.544 0 0
Suppression of apoptosis R-HSA-9635465 4.227028e-01 0.374 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.247914e-01 0.648 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 3.312509e-01 0.480 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.410298e-01 0.618 0 0
Muscarinic acetylcholine receptors R-HSA-390648 3.321155e-01 0.479 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 4.014245e-01 0.396 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.908996e-01 0.536 0 0
Glycolysis R-HSA-70171 3.350434e-01 0.475 0 0
Formation of definitive endoderm R-HSA-9823730 2.522776e-01 0.598 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 2.853986e-01 0.545 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 3.214753e-01 0.493 0 0
Interleukin-1 family signaling R-HSA-446652 2.384453e-01 0.623 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 3.545412e-01 0.450 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 3.176997e-01 0.498 0 0
G1/S-Specific Transcription R-HSA-69205 3.082071e-01 0.511 0 0
Maturation of nucleoprotein R-HSA-9694631 3.837393e-01 0.416 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.943334e-01 0.531 0 0
Oligomerization of connexins into connexons R-HSA-190704 3.983560e-01 0.400 0 0
Inhibition of membrane repair R-HSA-9635644 3.983560e-01 0.400 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.983560e-01 0.400 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 2.855477e-01 0.544 0 0
Hedgehog ligand biogenesis R-HSA-5358346 3.020460e-01 0.520 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 4.388397e-01 0.358 0 0
Activation of BH3-only proteins R-HSA-114452 2.692685e-01 0.570 0 0
Signal regulatory protein family interactions R-HSA-391160 3.635832e-01 0.439 0 0
Base Excision Repair R-HSA-73884 3.235239e-01 0.490 0 0
CASP4 inflammasome assembly R-HSA-9948001 3.777143e-01 0.423 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 2.533248e-01 0.596 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 3.082071e-01 0.511 0 0
Degradation of AXIN R-HSA-4641257 3.312509e-01 0.480 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 3.312509e-01 0.480 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 3.545863e-01 0.450 0 0
Regulation of PTEN stability and activity R-HSA-8948751 2.404056e-01 0.619 0 0
Inositol phosphate metabolism R-HSA-1483249 2.833150e-01 0.548 0 0
Diseases of DNA repair R-HSA-9675135 4.316887e-01 0.365 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 3.924875e-01 0.406 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 3.924875e-01 0.406 0 0
Vpu mediated degradation of CD4 R-HSA-180534 2.417493e-01 0.617 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 2.633648e-01 0.579 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 2.633648e-01 0.579 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.555856e-01 0.592 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 4.093462e-01 0.388 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 4.093462e-01 0.388 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.082071e-01 0.511 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 3.611057e-01 0.442 0 0
Sensory processing of sound R-HSA-9659379 3.101812e-01 0.508 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 4.267465e-01 0.370 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 4.227028e-01 0.374 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.246057e-01 0.649 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.781216e-01 0.422 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.642374e-01 0.578 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.642374e-01 0.578 0 0
Stabilization of p53 R-HSA-69541 3.781216e-01 0.422 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 4.418873e-01 0.355 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 4.432733e-01 0.353 0 0
RNA Polymerase III Transcription R-HSA-74158 4.432733e-01 0.353 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 4.460286e-01 0.351 0 0
Ion transport by P-type ATPases R-HSA-936837 4.461465e-01 0.351 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 4.490377e-01 0.348 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 4.490396e-01 0.348 0 0
Lagging Strand Synthesis R-HSA-69186 4.494596e-01 0.347 0 0
Platelet degranulation R-HSA-114608 4.498554e-01 0.347 0 0
Interleukin-17 signaling R-HSA-448424 4.499857e-01 0.347 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 4.502653e-01 0.347 0 0
STAT5 Activation R-HSA-9645135 4.502653e-01 0.347 0 0
Erythropoietin activates STAT5 R-HSA-9027283 4.502653e-01 0.347 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 4.502653e-01 0.347 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 4.502653e-01 0.347 0 0
CREB phosphorylation R-HSA-199920 4.502653e-01 0.347 0 0
Vesicle-mediated transport R-HSA-5653656 4.565569e-01 0.341 0 0
Signaling by WNT in cancer R-HSA-4791275 4.633281e-01 0.334 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 4.649224e-01 0.333 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 4.665231e-01 0.331 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.665231e-01 0.331 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 4.665231e-01 0.331 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 4.665231e-01 0.331 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.665231e-01 0.331 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 4.665231e-01 0.331 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.665231e-01 0.331 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 4.685874e-01 0.329 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.725034e-01 0.326 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 4.755421e-01 0.323 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 4.755421e-01 0.323 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 4.755421e-01 0.323 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 4.755421e-01 0.323 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 4.786646e-01 0.320 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.793234e-01 0.319 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 4.816672e-01 0.317 0 0
Attachment and Entry R-HSA-9694614 4.816672e-01 0.317 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.862823e-01 0.313 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 4.862823e-01 0.313 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 4.862823e-01 0.313 0 0
Nuclear Receptor transcription pathway R-HSA-383280 4.892646e-01 0.310 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 4.899847e-01 0.310 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 4.899847e-01 0.310 0 0
Nuclear RNA decay R-HSA-9930044 4.899847e-01 0.310 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 4.912697e-01 0.309 0 0
Signalling to ERK5 R-HSA-198765 4.921014e-01 0.308 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.921014e-01 0.308 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.921014e-01 0.308 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 4.921014e-01 0.308 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.921014e-01 0.308 0 0
Signaling by RAS GAP mutants R-HSA-9753510 4.921014e-01 0.308 0 0
Defective DHDDS causes RP59 R-HSA-4755609 4.921014e-01 0.308 0 0
Glycogen storage disease type IV (GBE1) R-HSA-3878781 4.921014e-01 0.308 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 4.921014e-01 0.308 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 4.921014e-01 0.308 0 0
Defective ADA disrupts (deoxy)adenosine deamination R-HSA-9734735 4.921014e-01 0.308 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.921014e-01 0.308 0 0
Defective ABCB6 causes MCOPCB7 R-HSA-5683371 4.921014e-01 0.308 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.921014e-01 0.308 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 4.921014e-01 0.308 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 4.921014e-01 0.308 0 0
Diseases of Cellular Senescence R-HSA-9630747 4.921014e-01 0.308 0 0
Diseases of cellular response to stress R-HSA-9675132 4.921014e-01 0.308 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 4.921014e-01 0.308 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 4.955769e-01 0.305 0 0
Response of Mtb to phagocytosis R-HSA-9637690 4.957500e-01 0.305 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 4.966876e-01 0.304 0 0
Gap junction trafficking and regulation R-HSA-157858 4.980999e-01 0.303 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.021147e-01 0.299 0 0
Activation of TRKA receptors R-HSA-187015 5.047919e-01 0.297 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 5.047919e-01 0.297 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 5.047919e-01 0.297 0 0
Disinhibition of SNARE formation R-HSA-114516 5.047919e-01 0.297 0 0
PTK6 Expression R-HSA-8849473 5.047919e-01 0.297 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 5.047919e-01 0.297 0 0
Netrin mediated repulsion signals R-HSA-418886 5.047919e-01 0.297 0 0
SLC-mediated transport of oligopeptides R-HSA-9959399 5.047919e-01 0.297 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 5.088000e-01 0.293 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 5.088000e-01 0.293 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 5.088000e-01 0.293 0 0
IRAK1 recruits IKK complex R-HSA-937039 5.088000e-01 0.293 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 5.088000e-01 0.293 0 0
VLDLR internalisation and degradation R-HSA-8866427 5.088000e-01 0.293 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 5.088000e-01 0.293 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 5.110244e-01 0.292 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 5.112885e-01 0.291 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 5.112885e-01 0.291 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 5.132015e-01 0.290 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 5.132015e-01 0.290 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 5.132015e-01 0.290 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 5.132015e-01 0.290 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 5.148120e-01 0.288 0 0
Generic Transcription Pathway R-HSA-212436 5.192792e-01 0.285 0 0
PI3K Cascade R-HSA-109704 5.198192e-01 0.284 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 5.208658e-01 0.283 0 0
tRNA processing in the nucleus R-HSA-6784531 5.218590e-01 0.282 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 5.243973e-01 0.280 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 5.333163e-01 0.273 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 5.419784e-01 0.266 0 0
Signal amplification R-HSA-392518 5.419784e-01 0.266 0 0
NOD1/2 Signaling Pathway R-HSA-168638 5.419784e-01 0.266 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 5.427141e-01 0.265 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 5.427141e-01 0.265 0 0
Platelet calcium homeostasis R-HSA-418360 5.427141e-01 0.265 0 0
Growth hormone receptor signaling R-HSA-982772 5.439132e-01 0.264 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 5.439594e-01 0.264 0 0
Rab regulation of trafficking R-HSA-9007101 5.443286e-01 0.264 0 0
Signaling by Hedgehog R-HSA-5358351 5.458577e-01 0.263 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 5.458779e-01 0.263 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 5.458779e-01 0.263 0 0
Platelet sensitization by LDL R-HSA-432142 5.458779e-01 0.263 0 0
Transport of connexons to the plasma membrane R-HSA-190872 5.458779e-01 0.263 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 5.458779e-01 0.263 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 5.458779e-01 0.263 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 5.458779e-01 0.263 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 5.492481e-01 0.260 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 5.492481e-01 0.260 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.492481e-01 0.260 0 0
Maturation of nucleoprotein R-HSA-9683610 5.492481e-01 0.260 0 0
Cilium Assembly R-HSA-5617833 5.493975e-01 0.260 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 5.556777e-01 0.255 0 0
Type I hemidesmosome assembly R-HSA-446107 5.556777e-01 0.255 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 5.556777e-01 0.255 0 0
TGFBR3 PTM regulation R-HSA-9839383 5.556777e-01 0.255 0 0
Interleukin-9 signaling R-HSA-8985947 5.556777e-01 0.255 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 5.556777e-01 0.255 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 5.556777e-01 0.255 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 5.584991e-01 0.253 0 0
Signaling by Insulin receptor R-HSA-74752 5.587430e-01 0.253 0 0
Autophagy R-HSA-9612973 5.594148e-01 0.252 0 0
Influenza Infection R-HSA-168255 5.602201e-01 0.252 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.622908e-01 0.250 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 5.635098e-01 0.249 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.650823e-01 0.248 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 5.698877e-01 0.244 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.698877e-01 0.244 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 5.698877e-01 0.244 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 5.698877e-01 0.244 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 5.712444e-01 0.243 0 0
Axonal growth stimulation R-HSA-209563 5.712444e-01 0.243 0 0
MET interacts with TNS proteins R-HSA-8875513 5.712444e-01 0.243 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 5.712444e-01 0.243 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 5.712444e-01 0.243 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 5.712444e-01 0.243 0 0
Classical Kir channels R-HSA-1296053 5.712444e-01 0.243 0 0
Invadopodia formation R-HSA-8941237 5.712444e-01 0.243 0 0
Signalling to STAT3 R-HSA-198745 5.712444e-01 0.243 0 0
Defective gamma-carboxylation of F9 R-HSA-9673240 5.712444e-01 0.243 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 5.712444e-01 0.243 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 5.712444e-01 0.243 0 0
MET activates STAT3 R-HSA-8875791 5.712444e-01 0.243 0 0
Intracellular oxygen transport R-HSA-8981607 5.712444e-01 0.243 0 0
FasL/ CD95L signaling R-HSA-75157 5.712444e-01 0.243 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 5.726020e-01 0.242 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 5.726020e-01 0.242 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 5.732366e-01 0.242 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 5.736764e-01 0.241 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 5.791494e-01 0.237 0 0
The NLRP3 inflammasome R-HSA-844456 5.791494e-01 0.237 0 0
STING mediated induction of host immune responses R-HSA-1834941 5.791494e-01 0.237 0 0
Developmental Biology R-HSA-1266738 5.846161e-01 0.233 0 0
Macroautophagy R-HSA-1632852 5.847115e-01 0.233 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.871099e-01 0.231 0 0
Malate-aspartate shuttle R-HSA-9856872 5.876622e-01 0.231 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 5.876622e-01 0.231 0 0
Non-canonical inflammasome activation R-HSA-9686114 5.876622e-01 0.231 0 0
ER-Phagosome pathway R-HSA-1236974 5.915705e-01 0.228 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 5.942038e-01 0.226 0 0
Integrin cell surface interactions R-HSA-216083 5.943520e-01 0.226 0 0
ER to Golgi Anterograde Transport R-HSA-199977 5.968432e-01 0.224 0 0
G protein gated Potassium channels R-HSA-1296059 6.023877e-01 0.220 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 6.023877e-01 0.220 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 6.023877e-01 0.220 0 0
Interleukin-7 signaling R-HSA-1266695 6.023877e-01 0.220 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 6.027335e-01 0.220 0 0
ARMS-mediated activation R-HSA-170984 6.027335e-01 0.220 0 0
Interleukin-21 signaling R-HSA-9020958 6.027335e-01 0.220 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 6.027335e-01 0.220 0 0
Hypusine synthesis from eIF5A-lysine R-HSA-204626 6.027335e-01 0.220 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 6.027335e-01 0.220 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 6.027335e-01 0.220 0 0
p75NTR regulates axonogenesis R-HSA-193697 6.027335e-01 0.220 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 6.027335e-01 0.220 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 6.027335e-01 0.220 0 0
Cellular response to mitochondrial stress R-HSA-9840373 6.027335e-01 0.220 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 6.027335e-01 0.220 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 6.027335e-01 0.220 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 6.027335e-01 0.220 0 0
Regulated proteolysis of p75NTR R-HSA-193692 6.027335e-01 0.220 0 0
MAPK1 (ERK2) activation R-HSA-112411 6.027335e-01 0.220 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 6.027335e-01 0.220 0 0
Nucleotide Excision Repair R-HSA-5696398 6.032755e-01 0.219 0 0
GPER1 signaling R-HSA-9634597 6.064548e-01 0.217 0 0
Signaling by TGFB family members R-HSA-9006936 6.077961e-01 0.216 0 0
Late Phase of HIV Life Cycle R-HSA-162599 6.099224e-01 0.215 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 6.104644e-01 0.214 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 6.109792e-01 0.214 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.109792e-01 0.214 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 6.109792e-01 0.214 0 0
Creatine metabolism R-HSA-71288 6.109792e-01 0.214 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 6.137737e-01 0.212 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 6.137737e-01 0.212 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 6.154266e-01 0.211 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 6.203978e-01 0.207 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 6.211631e-01 0.207 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 6.217193e-01 0.206 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 6.239061e-01 0.205 0 0
Biotin transport and metabolism R-HSA-196780 6.239061e-01 0.205 0 0
p75NTR signals via NF-kB R-HSA-193639 6.239061e-01 0.205 0 0
Protein methylation R-HSA-8876725 6.239061e-01 0.205 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 6.239061e-01 0.205 0 0
Toll-like Receptor Cascades R-HSA-168898 6.269689e-01 0.203 0 0
DNA Damage Bypass R-HSA-73893 6.271156e-01 0.203 0 0
Glucose metabolism R-HSA-70326 6.285958e-01 0.202 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 6.299651e-01 0.201 0 0
TRP channels R-HSA-3295583 6.299651e-01 0.201 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 6.299651e-01 0.201 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 6.319979e-01 0.199 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 6.380587e-01 0.195 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 6.380587e-01 0.195 0 0
Signaling by MAP2K mutants R-HSA-9652169 6.380587e-01 0.195 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 6.380587e-01 0.195 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 6.380587e-01 0.195 0 0
Alanine metabolism R-HSA-8964540 6.380587e-01 0.195 0 0
GABA synthesis R-HSA-888568 6.380587e-01 0.195 0 0
NADE modulates death signalling R-HSA-205025 6.380587e-01 0.195 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 6.380587e-01 0.195 0 0
Transmission across Electrical Synapses R-HSA-112307 6.380587e-01 0.195 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 6.380587e-01 0.195 0 0
Dopamine receptors R-HSA-390651 6.380587e-01 0.195 0 0
ERK/MAPK targets R-HSA-198753 6.412776e-01 0.193 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 6.412776e-01 0.193 0 0
Basigin interactions R-HSA-210991 6.412776e-01 0.193 0 0
Formation of apoptosome R-HSA-111458 6.459173e-01 0.190 0 0
Regulation of the apoptosome activity R-HSA-9627069 6.459173e-01 0.190 0 0
Binding and entry of HIV virion R-HSA-173107 6.459173e-01 0.190 0 0
Interleukin-27 signaling R-HSA-9020956 6.459173e-01 0.190 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 6.459173e-01 0.190 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 6.459173e-01 0.190 0 0
Maturation of spike protein R-HSA-9683686 6.459173e-01 0.190 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 6.459173e-01 0.190 0 0
Receptor Mediated Mitophagy R-HSA-8934903 6.459173e-01 0.190 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 6.459173e-01 0.190 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 6.479693e-01 0.188 0 0
Leishmania phagocytosis R-HSA-9664417 6.479693e-01 0.188 0 0
Parasite infection R-HSA-9664407 6.479693e-01 0.188 0 0
Gap junction trafficking R-HSA-190828 6.532626e-01 0.185 0 0
Eukaryotic Translation Elongation R-HSA-156842 6.535478e-01 0.185 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 6.563465e-01 0.183 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 6.563465e-01 0.183 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 6.563465e-01 0.183 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 6.573243e-01 0.182 0 0
Killing mechanisms R-HSA-9664420 6.579025e-01 0.182 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.579025e-01 0.182 0 0
Negative regulation of FLT3 R-HSA-9706369 6.579025e-01 0.182 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.579025e-01 0.182 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 6.579025e-01 0.182 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 6.606361e-01 0.180 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.699850e-01 0.174 0 0
Ribavirin ADME R-HSA-9755088 6.699850e-01 0.174 0 0
Selective autophagy R-HSA-9663891 6.717033e-01 0.173 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 6.731729e-01 0.172 0 0
Cellular response to chemical stress R-HSA-9711123 6.752843e-01 0.171 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 6.755390e-01 0.170 1 1
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 6.814880e-01 0.167 0 0
Formation of the Early Elongation Complex R-HSA-113418 6.814880e-01 0.167 0 0
HIV elongation arrest and recovery R-HSA-167287 6.814880e-01 0.167 0 0
Pausing and recovery of HIV elongation R-HSA-167290 6.814880e-01 0.167 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 6.814880e-01 0.167 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 6.819858e-01 0.166 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 6.819858e-01 0.166 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 6.852930e-01 0.164 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 6.852930e-01 0.164 0 0
Formation of the posterior neural plate R-HSA-9832991 6.852930e-01 0.164 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 6.852930e-01 0.164 0 0
Chylomicron assembly R-HSA-8963888 6.852930e-01 0.164 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.896227e-01 0.161 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 6.896227e-01 0.161 0 0
Dual Incision in GG-NER R-HSA-5696400 6.923054e-01 0.160 0 0
Signaling by NOTCH2 R-HSA-1980145 6.923054e-01 0.160 0 0
Gastrulation R-HSA-9758941 6.925295e-01 0.160 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 6.944644e-01 0.158 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 6.944644e-01 0.158 0 0
NTRK2 activates RAC1 R-HSA-9032759 6.944644e-01 0.158 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 6.944644e-01 0.158 0 0
Defective F9 activation R-HSA-9673221 6.944644e-01 0.158 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 6.944644e-01 0.158 0 0
Activation of AKT2 R-HSA-165158 6.944644e-01 0.158 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 6.944644e-01 0.158 0 0
Suppression of autophagy R-HSA-9636569 6.944644e-01 0.158 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 6.944644e-01 0.158 0 0
Inositol transporters R-HSA-429593 6.944644e-01 0.158 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 6.944644e-01 0.158 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 6.944644e-01 0.158 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 6.944644e-01 0.158 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 6.944644e-01 0.158 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 6.944644e-01 0.158 0 0
Regulation of beta-cell development R-HSA-186712 6.963540e-01 0.157 0 0
FGFR2 alternative splicing R-HSA-6803529 6.970686e-01 0.157 0 0
Cellular hexose transport R-HSA-189200 6.970686e-01 0.157 0 0
LDL clearance R-HSA-8964038 6.970686e-01 0.157 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 7.024630e-01 0.153 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 7.053623e-01 0.152 0 0
Regulation of gene expression in beta cells R-HSA-210745 7.053623e-01 0.152 0 0
Termination of translesion DNA synthesis R-HSA-5656169 7.053623e-01 0.152 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.103439e-01 0.149 0 0
Kinesins R-HSA-983189 7.132577e-01 0.147 0 0
Oncogene Induced Senescence R-HSA-2559585 7.137802e-01 0.146 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 7.146580e-01 0.146 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 7.195237e-01 0.143 0 0
DS-GAG biosynthesis R-HSA-2022923 7.209987e-01 0.142 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 7.209987e-01 0.142 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 7.209987e-01 0.142 0 0
NF-kB is activated and signals survival R-HSA-209560 7.209987e-01 0.142 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 7.209987e-01 0.142 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 7.209987e-01 0.142 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 7.209987e-01 0.142 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 7.225188e-01 0.141 0 0
Antigen processing-Cross presentation R-HSA-1236975 7.277048e-01 0.138 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.279570e-01 0.138 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 7.342006e-01 0.134 0 0
NGF-independant TRKA activation R-HSA-187024 7.420824e-01 0.130 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 7.420824e-01 0.130 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 7.420824e-01 0.130 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 7.420824e-01 0.130 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 7.420824e-01 0.130 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 7.420824e-01 0.130 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 7.420824e-01 0.130 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 7.420824e-01 0.130 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 7.420824e-01 0.130 0 0
Pentose phosphate pathway disease R-HSA-6791465 7.420824e-01 0.130 0 0
Synthesis of PS R-HSA-1483101 7.420824e-01 0.130 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 7.420824e-01 0.130 0 0
PKB-mediated events R-HSA-109703 7.420824e-01 0.130 0 0
PDE3B signalling R-HSA-165160 7.420824e-01 0.130 0 0
Threonine catabolism R-HSA-8849175 7.420824e-01 0.130 0 0
Cam-PDE 1 activation R-HSA-111957 7.420824e-01 0.130 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 7.420824e-01 0.130 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 7.420824e-01 0.130 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 7.420824e-01 0.130 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 7.420824e-01 0.130 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 7.420824e-01 0.130 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 7.420824e-01 0.130 0 0
PKA activation R-HSA-163615 7.463115e-01 0.127 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 7.463115e-01 0.127 0 0
Complex III assembly R-HSA-9865881 7.463454e-01 0.127 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 7.463454e-01 0.127 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 7.473403e-01 0.126 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.492726e-01 0.125 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 7.523350e-01 0.124 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 7.532218e-01 0.123 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 7.532218e-01 0.123 0 0
Regulation of IFNG signaling R-HSA-877312 7.532218e-01 0.123 0 0
Interleukin-35 Signalling R-HSA-8984722 7.532218e-01 0.123 0 0
p75NTR recruits signalling complexes R-HSA-209543 7.532218e-01 0.123 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 7.532218e-01 0.123 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 7.532218e-01 0.123 0 0
OAS antiviral response R-HSA-8983711 7.532218e-01 0.123 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 7.578175e-01 0.120 0 0
Peptide chain elongation R-HSA-156902 7.595889e-01 0.119 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 7.602490e-01 0.119 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.657392e-01 0.116 0 0
Viral Infection Pathways R-HSA-9824446 7.681410e-01 0.115 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.693210e-01 0.114 0 0
Crosslinking of collagen fibrils R-HSA-2243919 7.713911e-01 0.113 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 7.713911e-01 0.113 0 0
Other interleukin signaling R-HSA-449836 7.713911e-01 0.113 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 7.713911e-01 0.113 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 7.713911e-01 0.113 0 0
Diseases of hemostasis R-HSA-9671793 7.713911e-01 0.113 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 7.725174e-01 0.112 0 0
HCMV Late Events R-HSA-9610379 7.738344e-01 0.111 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 7.741066e-01 0.111 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 7.781146e-01 0.109 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 7.821805e-01 0.107 0 0
Chylomicron remodeling R-HSA-8963901 7.821805e-01 0.107 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 7.821805e-01 0.107 0 0
Processing of SMDT1 R-HSA-8949664 7.821805e-01 0.107 0 0
Formation of axial mesoderm R-HSA-9796292 7.821805e-01 0.107 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 7.821805e-01 0.107 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 7.821805e-01 0.107 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 7.821805e-01 0.107 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 7.821805e-01 0.107 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 7.821805e-01 0.107 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 7.822814e-01 0.107 0 0
Chylomicron clearance R-HSA-8964026 7.822814e-01 0.107 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 7.822814e-01 0.107 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 7.822814e-01 0.107 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 7.822814e-01 0.107 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 7.822814e-01 0.107 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 7.822814e-01 0.107 0 0
MET Receptor Activation R-HSA-6806942 7.822814e-01 0.107 0 0
Lactose synthesis R-HSA-5653890 7.822814e-01 0.107 0 0
Abacavir transmembrane transport R-HSA-2161517 7.822814e-01 0.107 0 0
HDL clearance R-HSA-8964011 7.822814e-01 0.107 0 0
Leukotriene receptors R-HSA-391906 7.822814e-01 0.107 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 7.822814e-01 0.107 0 0
Developmental Cell Lineages R-HSA-9734767 7.829125e-01 0.106 0 0
ABC transporter disorders R-HSA-5619084 7.853467e-01 0.105 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 7.891538e-01 0.103 0 0
Plasma lipoprotein clearance R-HSA-8964043 7.891538e-01 0.103 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.891538e-01 0.103 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 7.892478e-01 0.103 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 7.892478e-01 0.103 0 0
Suppression of phagosomal maturation R-HSA-9637687 7.892478e-01 0.103 0 0
HCMV Early Events R-HSA-9609690 7.911968e-01 0.102 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 7.914202e-01 0.102 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 7.931698e-01 0.101 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 7.944253e-01 0.100 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 8.005611e-01 0.097 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 8.054116e-01 0.094 0 0
Generation of second messenger molecules R-HSA-202433 8.054116e-01 0.094 0 0
HIV Transcription Elongation R-HSA-167169 8.054116e-01 0.094 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 8.054116e-01 0.094 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.054116e-01 0.094 0 0
Diseases of Immune System R-HSA-5260271 8.054116e-01 0.094 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.057106e-01 0.094 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.057106e-01 0.094 0 0
Integration of energy metabolism R-HSA-163685 8.060559e-01 0.094 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.065466e-01 0.093 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 8.081093e-01 0.093 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 8.081093e-01 0.093 0 0
Prolactin receptor signaling R-HSA-1170546 8.081093e-01 0.093 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.081093e-01 0.093 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.084142e-01 0.092 0 0
Cristae formation R-HSA-8949613 8.084142e-01 0.092 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.084142e-01 0.092 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 8.084142e-01 0.092 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.085757e-01 0.092 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 8.085757e-01 0.092 0 0
Metabolism of polyamines R-HSA-351202 8.111762e-01 0.091 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.148488e-01 0.089 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 8.154479e-01 0.089 0 0
G-protein activation R-HSA-202040 8.154479e-01 0.089 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 8.154479e-01 0.089 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 8.154479e-01 0.089 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 8.154479e-01 0.089 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 8.154479e-01 0.089 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 8.154992e-01 0.089 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 8.162170e-01 0.088 0 0
Recycling of eIF2:GDP R-HSA-72731 8.162170e-01 0.088 0 0
FGFR3b ligand binding and activation R-HSA-190371 8.162170e-01 0.088 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 8.162170e-01 0.088 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 8.162170e-01 0.088 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 8.162170e-01 0.088 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 8.162170e-01 0.088 0 0
Reuptake of GABA R-HSA-888593 8.162170e-01 0.088 0 0
Mitochondrial ABC transporters R-HSA-1369007 8.162170e-01 0.088 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 8.162170e-01 0.088 0 0
VLDL clearance R-HSA-8964046 8.162170e-01 0.088 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 8.162170e-01 0.088 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 8.162170e-01 0.088 0 0
Maturation of replicase proteins R-HSA-9694301 8.162170e-01 0.088 0 0
Regulation of insulin secretion R-HSA-422356 8.213368e-01 0.085 0 0
Mitophagy R-HSA-5205647 8.221177e-01 0.085 0 0
RA biosynthesis pathway R-HSA-5365859 8.221177e-01 0.085 0 0
Insulin receptor recycling R-HSA-77387 8.261336e-01 0.083 0 0
Pyrimidine salvage R-HSA-73614 8.261336e-01 0.083 0 0
Inflammasomes R-HSA-622312 8.261336e-01 0.083 0 0
Pyroptosis R-HSA-5620971 8.261336e-01 0.083 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 8.286729e-01 0.082 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 8.312492e-01 0.080 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.312492e-01 0.080 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 8.312492e-01 0.080 0 0
p38MAPK events R-HSA-171007 8.312492e-01 0.080 0 0
Protein lipoylation R-HSA-9857492 8.312492e-01 0.080 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.312492e-01 0.080 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 8.312492e-01 0.080 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 8.312492e-01 0.080 0 0
Formation of the anterior neural plate R-HSA-9823739 8.312492e-01 0.080 0 0
DNA Damage Reversal R-HSA-73942 8.312492e-01 0.080 0 0
Interferon Signaling R-HSA-913531 8.336335e-01 0.079 0 0
Ion channel transport R-HSA-983712 8.340242e-01 0.079 0 0
Gluconeogenesis R-HSA-70263 8.342485e-01 0.079 0 0
G alpha (z) signalling events R-HSA-418597 8.346322e-01 0.079 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 8.346322e-01 0.079 0 0
Mitochondrial calcium ion transport R-HSA-8949215 8.346338e-01 0.079 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 8.346338e-01 0.079 0 0
Intra-Golgi traffic R-HSA-6811438 8.349750e-01 0.078 0 0
RSK activation R-HSA-444257 8.448646e-01 0.073 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 8.448646e-01 0.073 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 8.448646e-01 0.073 0 0
FGFR1b ligand binding and activation R-HSA-190370 8.448646e-01 0.073 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 8.448646e-01 0.073 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 8.448646e-01 0.073 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 8.448646e-01 0.073 0 0
Activation of RAS in B cells R-HSA-1169092 8.448646e-01 0.073 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 8.448646e-01 0.073 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 8.448646e-01 0.073 0 0
Nucleotide salvage defects R-HSA-9734207 8.448646e-01 0.073 0 0
SLC-mediated bile acid transport R-HSA-9958517 8.448646e-01 0.073 0 0
Adrenoceptors R-HSA-390696 8.448646e-01 0.073 0 0
Modulation by Mtb of host immune system R-HSA-9637628 8.448646e-01 0.073 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 8.465739e-01 0.072 0 0
Activation of GABAB receptors R-HSA-991365 8.483419e-01 0.071 0 0
GABA B receptor activation R-HSA-977444 8.483419e-01 0.071 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.518394e-01 0.070 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.518394e-01 0.070 0 0
Fructose catabolism R-HSA-70350 8.518394e-01 0.070 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.518394e-01 0.070 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.518394e-01 0.070 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.520751e-01 0.070 0 0
Ethanol oxidation R-HSA-71384 8.520751e-01 0.070 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 8.520751e-01 0.070 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 8.520751e-01 0.070 0 0
Eukaryotic Translation Termination R-HSA-72764 8.557235e-01 0.068 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.574965e-01 0.067 0 0
PI Metabolism R-HSA-1483255 8.580169e-01 0.067 0 0
Stimuli-sensing channels R-HSA-2672351 8.603864e-01 0.065 0 0
Lipophagy R-HSA-9613354 8.690481e-01 0.061 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 8.690481e-01 0.061 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 8.690481e-01 0.061 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 8.690481e-01 0.061 0 0
Lysosomal oligosaccharide catabolism R-HSA-8853383 8.690481e-01 0.061 0 0
Interleukin-1 processing R-HSA-448706 8.690481e-01 0.061 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 8.690481e-01 0.061 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 8.696527e-01 0.061 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 8.701125e-01 0.060 0 0
Heme assimilation R-HSA-9927020 8.701125e-01 0.060 0 0
Coenzyme A biosynthesis R-HSA-196783 8.701125e-01 0.060 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.701125e-01 0.060 0 0
Synthesis of PG R-HSA-1483148 8.701125e-01 0.060 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 8.701125e-01 0.060 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 8.701125e-01 0.060 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 8.701125e-01 0.060 0 0
Response to metal ions R-HSA-5660526 8.701125e-01 0.060 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 8.701820e-01 0.060 0 0
Hemostasis R-HSA-109582 8.709568e-01 0.060 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.712821e-01 0.060 0 0
RMTs methylate histone arginines R-HSA-3214858 8.724213e-01 0.059 0 0
Transmission across Chemical Synapses R-HSA-112315 8.741580e-01 0.058 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 8.773882e-01 0.057 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 8.780373e-01 0.056 0 0
Cellular response to starvation R-HSA-9711097 8.798916e-01 0.056 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 8.821902e-01 0.054 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.821902e-01 0.054 0 0
HS-GAG degradation R-HSA-2024096 8.839016e-01 0.054 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 8.857303e-01 0.053 0 0
MHC class II antigen presentation R-HSA-2132295 8.862009e-01 0.052 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 8.862904e-01 0.052 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.862904e-01 0.052 0 0
Glycogen storage diseases R-HSA-3229121 8.862904e-01 0.052 0 0
GDP-fucose biosynthesis R-HSA-6787639 8.862904e-01 0.052 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.862904e-01 0.052 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 8.862904e-01 0.052 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.862904e-01 0.052 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 8.894629e-01 0.051 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.894629e-01 0.051 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.894629e-01 0.051 0 0
Sperm Motility And Taxes R-HSA-1300642 8.894629e-01 0.051 0 0
ABC-family proteins mediated transport R-HSA-382556 8.944998e-01 0.048 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.950951e-01 0.048 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.950951e-01 0.048 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.950951e-01 0.048 0 0
Formation of the nephric duct R-HSA-9830364 8.950951e-01 0.048 0 0
Platelet homeostasis R-HSA-418346 8.953300e-01 0.048 0 0
Glycogen metabolism R-HSA-8982491 8.983528e-01 0.047 0 0
Neuronal System R-HSA-112316 8.986449e-01 0.046 0 0
rRNA processing R-HSA-72312 8.994969e-01 0.046 0 0
Apoptotic factor-mediated response R-HSA-111471 9.005821e-01 0.045 0 0
PKA activation in glucagon signalling R-HSA-164378 9.005821e-01 0.045 0 0
Nephron development R-HSA-9831926 9.005821e-01 0.045 0 0
Mismatch Repair R-HSA-5358508 9.005821e-01 0.045 0 0
Selenocysteine synthesis R-HSA-2408557 9.011369e-01 0.045 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 9.059371e-01 0.043 0 0
FGFR2b ligand binding and activation R-HSA-190377 9.066961e-01 0.043 0 0
vRNP Assembly R-HSA-192905 9.066961e-01 0.043 0 0
vRNA Synthesis R-HSA-192814 9.066961e-01 0.043 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 9.066961e-01 0.043 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 9.066961e-01 0.043 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 9.066961e-01 0.043 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 9.066961e-01 0.043 0 0
Prostanoid ligand receptors R-HSA-391908 9.066961e-01 0.043 0 0
Dissolution of Fibrin Clot R-HSA-75205 9.066961e-01 0.043 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.067144e-01 0.043 0 0
Metalloprotease DUBs R-HSA-5689901 9.067144e-01 0.043 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.131825e-01 0.039 0 0
Germ layer formation at gastrulation R-HSA-9754189 9.131825e-01 0.039 0 0
Rap1 signalling R-HSA-392517 9.131825e-01 0.039 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.131825e-01 0.039 0 0
Translesion Synthesis by POLH R-HSA-110320 9.131825e-01 0.039 0 0
HDL remodeling R-HSA-8964058 9.131825e-01 0.039 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.131825e-01 0.039 0 0
Viral mRNA Translation R-HSA-192823 9.133844e-01 0.039 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.145847e-01 0.039 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.149140e-01 0.039 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.154977e-01 0.038 0 0
eNOS activation R-HSA-203615 9.154977e-01 0.038 0 0
Gap junction assembly R-HSA-190861 9.154977e-01 0.038 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.154977e-01 0.038 0 0
Negative regulation of MAPK pathway R-HSA-5675221 9.165275e-01 0.038 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.165275e-01 0.038 0 0
Translation of Structural Proteins R-HSA-9683701 9.165275e-01 0.038 0 0
ECM proteoglycans R-HSA-3000178 9.168504e-01 0.038 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.171549e-01 0.038 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.189540e-01 0.037 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.189540e-01 0.037 0 0
HCMV Infection R-HSA-9609646 9.193062e-01 0.037 0 0
Adaptive Immune System R-HSA-1280218 9.210438e-01 0.036 1 0
Gamma-carboxylation of protein precursors R-HSA-159740 9.212434e-01 0.036 0 0
ERKs are inactivated R-HSA-202670 9.212434e-01 0.036 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 9.212434e-01 0.036 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 9.212434e-01 0.036 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 9.212434e-01 0.036 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 9.212434e-01 0.036 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 9.212434e-01 0.036 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 9.212434e-01 0.036 0 0
Anchoring fibril formation R-HSA-2214320 9.212434e-01 0.036 0 0
Sodium/Calcium exchangers R-HSA-425561 9.212434e-01 0.036 0 0
Dectin-2 family R-HSA-5621480 9.221105e-01 0.035 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.242715e-01 0.034 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.242715e-01 0.034 0 0
Glycogen synthesis R-HSA-3322077 9.242715e-01 0.034 0 0
Protein hydroxylation R-HSA-9629569 9.242715e-01 0.034 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.242715e-01 0.034 0 0
RSV-host interactions R-HSA-9833110 9.243424e-01 0.034 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.252323e-01 0.034 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.265184e-01 0.033 0 0
Dual incision in TC-NER R-HSA-6782135 9.287719e-01 0.032 0 0
FOXO-mediated transcription R-HSA-9614085 9.298023e-01 0.032 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.317737e-01 0.031 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.320516e-01 0.031 0 0
Maple Syrup Urine Disease R-HSA-9865114 9.335233e-01 0.030 0 0
Beta oxidation of myristoyl-CoA to lauroyl-CoA R-HSA-77285 9.335233e-01 0.030 0 0
Beta oxidation of palmitoyl-CoA to myristoyl-CoA R-HSA-77305 9.335233e-01 0.030 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 9.335233e-01 0.030 0 0
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-HSA-159854 9.335233e-01 0.030 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 9.335233e-01 0.030 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 9.335233e-01 0.030 0 0
Estrogen biosynthesis R-HSA-193144 9.335233e-01 0.030 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 9.335233e-01 0.030 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.340139e-01 0.030 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.340139e-01 0.030 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.340139e-01 0.030 0 0
Leishmania infection R-HSA-9658195 9.347096e-01 0.029 0 0
Parasitic Infection Pathways R-HSA-9824443 9.347096e-01 0.029 0 0
mRNA Capping R-HSA-72086 9.349009e-01 0.029 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.349009e-01 0.029 0 0
Glucagon-type ligand receptors R-HSA-420092 9.349009e-01 0.029 0 0
Voltage gated Potassium channels R-HSA-1296072 9.391756e-01 0.027 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.400876e-01 0.027 0 0
RAB geranylgeranylation R-HSA-8873719 9.406129e-01 0.027 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.425601e-01 0.026 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.425601e-01 0.026 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 9.425601e-01 0.026 0 0
Transcription of the HIV genome R-HSA-167172 9.426275e-01 0.026 0 0
Adenylate cyclase activating pathway R-HSA-170660 9.438891e-01 0.025 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 9.438891e-01 0.025 0 0
FGFR2c ligand binding and activation R-HSA-190375 9.438891e-01 0.025 0 0
FGFR1c ligand binding and activation R-HSA-190373 9.438891e-01 0.025 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 9.438891e-01 0.025 0 0
FGFR4 ligand binding and activation R-HSA-190322 9.438891e-01 0.025 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 9.438891e-01 0.025 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 9.438891e-01 0.025 1 1
Signaling by activated point mutants of FGFR3 R-HSA-1839130 9.438891e-01 0.025 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 9.438891e-01 0.025 0 0
FGFR3 mutant receptor activation R-HSA-2033514 9.438891e-01 0.025 0 0
Diseases of nucleotide metabolism R-HSA-9735804 9.438891e-01 0.025 0 0
rRNA modification in the mitochondrion R-HSA-6793080 9.438891e-01 0.025 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.444810e-01 0.025 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.444810e-01 0.025 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.444810e-01 0.025 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.456128e-01 0.024 0 0
Elastic fibre formation R-HSA-1566948 9.456128e-01 0.024 0 0
Aquaporin-mediated transport R-HSA-445717 9.458523e-01 0.024 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.490772e-01 0.023 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.490772e-01 0.023 0 0
Translation of Structural Proteins R-HSA-9694635 9.494134e-01 0.023 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.498114e-01 0.022 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.500461e-01 0.022 0 0
Fructose metabolism R-HSA-5652084 9.500461e-01 0.022 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 9.500461e-01 0.022 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 9.500461e-01 0.022 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 9.526390e-01 0.021 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 9.526390e-01 0.021 0 0
FGFR3c ligand binding and activation R-HSA-190372 9.526390e-01 0.021 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 9.526390e-01 0.021 0 0
cGMP effects R-HSA-418457 9.526390e-01 0.021 0 0
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA R-HSA-77310 9.526390e-01 0.021 0 0
Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-HSA-77350 9.526390e-01 0.021 0 0
Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-HSA-77348 9.526390e-01 0.021 0 0
NRIF signals cell death from the nucleus R-HSA-205043 9.526390e-01 0.021 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.526390e-01 0.021 0 0
Acyl chain remodeling of CL R-HSA-1482798 9.526390e-01 0.021 0 0
Innate Immune System R-HSA-168249 9.539702e-01 0.020 1 0
Retinoid metabolism and transport R-HSA-975634 9.561028e-01 0.019 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.565948e-01 0.019 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.565948e-01 0.019 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.565948e-01 0.019 0 0
Formation of the ureteric bud R-HSA-9830674 9.565948e-01 0.019 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.565948e-01 0.019 0 0
Interleukin-20 family signaling R-HSA-8854691 9.565948e-01 0.019 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.566530e-01 0.019 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.566530e-01 0.019 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.566530e-01 0.019 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.572028e-01 0.019 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.587957e-01 0.018 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 9.600249e-01 0.018 0 0
FGFR3 ligand binding and activation R-HSA-190239 9.600249e-01 0.018 0 0
Transport and metabolism of PAPS R-HSA-174362 9.600249e-01 0.018 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 9.600249e-01 0.018 0 0
FASTK family proteins regulate processing and stability of mitochondrial RNAs R-HSA-9837092 9.600249e-01 0.018 0 0
Cardiogenesis R-HSA-9733709 9.603315e-01 0.018 0 0
tRNA processing R-HSA-72306 9.603325e-01 0.018 0 0
Maturation of spike protein R-HSA-9694548 9.613604e-01 0.017 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.623162e-01 0.017 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.623162e-01 0.017 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.623162e-01 0.017 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.623162e-01 0.017 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.623162e-01 0.017 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.650390e-01 0.015 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.650390e-01 0.015 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.650390e-01 0.015 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.655896e-01 0.015 0 0
HIV Transcription Initiation R-HSA-167161 9.655896e-01 0.015 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.655896e-01 0.015 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.662593e-01 0.015 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 9.662593e-01 0.015 0 0
Phase 4 - resting membrane potential R-HSA-5576886 9.662593e-01 0.015 0 0
Regulation of BACH1 activity R-HSA-9708530 9.662593e-01 0.015 0 0
Carnitine synthesis R-HSA-71262 9.662593e-01 0.015 0 0
Attachment and Entry R-HSA-9678110 9.662593e-01 0.015 0 0
Atorvastatin ADME R-HSA-9754706 9.662593e-01 0.015 0 0
Differentiation of T cells R-HSA-9945266 9.662593e-01 0.015 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 9.662593e-01 0.015 0 0
Virus Assembly and Release R-HSA-168268 9.662593e-01 0.015 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.672398e-01 0.014 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.691800e-01 0.014 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.692161e-01 0.014 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.692161e-01 0.014 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.693845e-01 0.014 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.697917e-01 0.013 0 0
Peroxisomal protein import R-HSA-9033241 9.697917e-01 0.013 0 0
Glycine degradation R-HSA-6783984 9.715218e-01 0.013 0 0
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids R-HSA-77288 9.715218e-01 0.013 0 0
Passive transport by Aquaporins R-HSA-432047 9.715218e-01 0.013 0 0
Fibronectin matrix formation R-HSA-1566977 9.715218e-01 0.013 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.715218e-01 0.013 0 0
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-HSA-77346 9.715218e-01 0.013 0 0
Abacavir ADME R-HSA-2161522 9.716618e-01 0.012 0 0
GABA receptor activation R-HSA-977443 9.727694e-01 0.012 0 0
tRNA Aminoacylation R-HSA-379724 9.727694e-01 0.012 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.727694e-01 0.012 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.727854e-01 0.012 0 0
PERK regulates gene expression R-HSA-381042 9.729178e-01 0.012 0 0
Immune System R-HSA-168256 9.751508e-01 0.011 1 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.752325e-01 0.011 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.754523e-01 0.011 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.754523e-01 0.011 0 0
Collagen degradation R-HSA-1442490 9.754741e-01 0.011 0 0
Surfactant metabolism R-HSA-5683826 9.758296e-01 0.011 0 0
Amine ligand-binding receptors R-HSA-375280 9.758296e-01 0.011 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.759637e-01 0.011 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.759637e-01 0.011 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.759637e-01 0.011 0 0
Choline catabolism R-HSA-6798163 9.759637e-01 0.011 0 0
HS-GAG biosynthesis R-HSA-2022928 9.761945e-01 0.010 0 0
Triglyceride catabolism R-HSA-163560 9.761945e-01 0.010 0 0
COPII-mediated vesicle transport R-HSA-204005 9.773447e-01 0.010 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.785515e-01 0.009 0 0
Neddylation R-HSA-8951664 9.785957e-01 0.009 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.787500e-01 0.009 0 0
Activated point mutants of FGFR2 R-HSA-2033519 9.797130e-01 0.009 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.797130e-01 0.009 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.797130e-01 0.009 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.797130e-01 0.009 0 0
G alpha (q) signalling events R-HSA-416476 9.801766e-01 0.009 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.809824e-01 0.008 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.816164e-01 0.008 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.816507e-01 0.008 0 0
Pyrimidine biosynthesis R-HSA-500753 9.828776e-01 0.008 0 0
Specification of the neural plate border R-HSA-9834899 9.828776e-01 0.008 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.829515e-01 0.007 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.831512e-01 0.007 0 0
Pentose phosphate pathway R-HSA-71336 9.839085e-01 0.007 0 0
Metal ion SLC transporters R-HSA-425410 9.850841e-01 0.007 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.855487e-01 0.006 0 0
Melanin biosynthesis R-HSA-5662702 9.855487e-01 0.006 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.858265e-01 0.006 0 0
Cargo concentration in the ER R-HSA-5694530 9.862661e-01 0.006 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.862661e-01 0.006 0 0
Kidney development R-HSA-9830369 9.871220e-01 0.006 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.871838e-01 0.006 0 0
Cardiac conduction R-HSA-5576891 9.872621e-01 0.006 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.878033e-01 0.005 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.878033e-01 0.005 0 0
Phenylalanine metabolism R-HSA-8964208 9.878033e-01 0.005 0 0
Abacavir metabolism R-HSA-2161541 9.878033e-01 0.005 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.878033e-01 0.005 0 0
Translation R-HSA-72766 9.878045e-01 0.005 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.881394e-01 0.005 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.881843e-01 0.005 0 0
Azathioprine ADME R-HSA-9748787 9.883361e-01 0.005 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.891937e-01 0.005 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.891937e-01 0.005 0 0
CS-GAG biosynthesis R-HSA-2022870 9.897062e-01 0.004 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.897062e-01 0.004 0 0
Assembly Of The HIV Virion R-HSA-175474 9.897062e-01 0.004 0 0
Serine metabolism R-HSA-977347 9.897062e-01 0.004 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.897062e-01 0.004 0 0
Extracellular matrix organization R-HSA-1474244 9.897587e-01 0.004 0 0
Interleukin-10 signaling R-HSA-6783783 9.901007e-01 0.004 0 0
PPARA activates gene expression R-HSA-1989781 9.902437e-01 0.004 0 0
Nucleotide salvage R-HSA-8956321 9.906470e-01 0.004 0 0
Mitochondrial protein degradation R-HSA-9837999 9.913028e-01 0.004 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.913123e-01 0.004 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.913123e-01 0.004 0 0
Mitochondrial protein import R-HSA-1268020 9.916871e-01 0.004 0 0
Interferon alpha/beta signaling R-HSA-909733 9.919061e-01 0.004 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.921100e-01 0.003 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.926679e-01 0.003 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.926679e-01 0.003 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.926679e-01 0.003 0 0
Carnitine shuttle R-HSA-200425 9.926679e-01 0.003 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.934361e-01 0.003 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.934361e-01 0.003 0 0
Potassium Channels R-HSA-1296071 9.935581e-01 0.003 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.936018e-01 0.003 0 0
Neurotransmitter release cycle R-HSA-112310 9.938348e-01 0.003 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.939175e-01 0.003 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.943935e-01 0.002 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.945054e-01 0.002 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.945054e-01 0.002 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.945054e-01 0.002 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.947777e-01 0.002 0 0
Hyaluronan degradation R-HSA-2160916 9.947777e-01 0.002 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.947777e-01 0.002 0 0
Fertilization R-HSA-1187000 9.947777e-01 0.002 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.947777e-01 0.002 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.951304e-01 0.002 0 0
NCAM1 interactions R-HSA-419037 9.951304e-01 0.002 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.951304e-01 0.002 0 0
Collagen chain trimerization R-HSA-8948216 9.951304e-01 0.002 0 0
Selenoamino acid metabolism R-HSA-2408522 9.952559e-01 0.002 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.954335e-01 0.002 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.955108e-01 0.002 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.955928e-01 0.002 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.955928e-01 0.002 0 0
Attachment of bacteria to epithelial cells R-HSA-9638630 9.955928e-01 0.002 0 0
Sphingolipid catabolism R-HSA-9845614 9.955928e-01 0.002 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.955928e-01 0.002 0 0
Infectious disease R-HSA-5663205 9.956368e-01 0.002 0 0
Intraflagellar transport R-HSA-5620924 9.958245e-01 0.002 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.958245e-01 0.002 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.962296e-01 0.002 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.962675e-01 0.002 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.962806e-01 0.002 0 0
Signaling by BMP R-HSA-201451 9.962806e-01 0.002 0 0
Insulin processing R-HSA-264876 9.962806e-01 0.002 0 0
SLC transporter disorders R-HSA-5619102 9.962998e-01 0.002 0 0
RAS processing R-HSA-9648002 9.963934e-01 0.002 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.963934e-01 0.002 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.968350e-01 0.001 0 0
Prednisone ADME R-HSA-9757110 9.968611e-01 0.001 0 0
Iron assimilation using enterobactin R-HSA-9638334 9.968611e-01 0.001 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.968979e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.972022e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.972446e-01 0.001 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.972446e-01 0.001 0 0
The phototransduction cascade R-HSA-2514856 9.972446e-01 0.001 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.973328e-01 0.001 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.973511e-01 0.001 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.975281e-01 0.001 0 0
Heme biosynthesis R-HSA-189451 9.977076e-01 0.001 0 0
Neurotransmitter clearance R-HSA-112311 9.977646e-01 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 9.979165e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.979589e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.979589e-01 0.001 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.980304e-01 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.980735e-01 0.001 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.982842e-01 0.001 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.983083e-01 0.001 0 0
Protein localization R-HSA-9609507 9.984361e-01 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 9.984672e-01 0.001 0 0
FCGR activation R-HSA-2029481 9.985093e-01 0.001 0 0
Methylation R-HSA-156581 9.985474e-01 0.001 0 0
Recycling of bile acids and salts R-HSA-159418 9.986566e-01 0.001 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.986566e-01 0.001 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.987302e-01 0.001 0 0
CS/DS degradation R-HSA-2024101 9.988664e-01 0.000 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.988664e-01 0.000 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.988664e-01 0.000 0 0
Heme degradation R-HSA-189483 9.988664e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.988755e-01 0.000 0 0
Hyaluronan metabolism R-HSA-2142845 9.990434e-01 0.000 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.990434e-01 0.000 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.990434e-01 0.000 0 0
Synthesis of PC R-HSA-1483191 9.990821e-01 0.000 0 0
Triglyceride metabolism R-HSA-8979227 9.991084e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.991524e-01 0.000 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.991928e-01 0.000 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.991928e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.992212e-01 0.000 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.992271e-01 0.000 0 0
Glycosphingolipid transport R-HSA-9845576 9.993188e-01 0.000 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.993188e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.994180e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.994215e-01 0.000 0 0
Ubiquinol biosynthesis R-HSA-2142789 9.994252e-01 0.000 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.994252e-01 0.000 0 0
Metabolism of folate and pterines R-HSA-196757 9.994252e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.994347e-01 0.000 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.995150e-01 0.000 0 0
Biofilm formation R-HSA-9931953 9.995150e-01 0.000 0 0
Purine salvage R-HSA-74217 9.995150e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.995568e-01 0.000 0 0
Collagen formation R-HSA-1474290 9.995815e-01 0.000 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.996547e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.997063e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.997185e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.997333e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.997773e-01 0.000 0 0
Disease R-HSA-1643685 9.997795e-01 0.000 0 0
Pyrimidine catabolism R-HSA-73621 9.998249e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.998430e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.998430e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.998430e-01 0.000 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.998523e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.998645e-01 0.000 0 0
mitochondrial fatty acid beta-oxidation of saturated fatty acids R-HSA-77286 9.998754e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.998954e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.999113e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999129e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999164e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.999236e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.999347e-01 0.000 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.999368e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999513e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.999550e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.999652e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.999652e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999772e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999778e-01 0.000 0 0
Interferon gamma signaling R-HSA-877300 9.999789e-01 0.000 0 0
Synthesis of PA R-HSA-1483166 9.999838e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999876e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999880e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999891e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999901e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.999939e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999941e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999945e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.999951e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.999970e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.999970e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999976e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999976e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999983e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999983e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999985e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999986e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999988e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.999991e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999995e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.999995e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999995e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999996e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999997e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999997e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999997e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999997e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999997e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999997e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999998e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999999e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999999e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999999e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999999e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways