PKCB

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
O00443 S58 Sugiyama PIK3C2A ALAKLQKDRQVTDNQRGFELsssTRKKAQVyNKQDyDLMVF
O14974 S910 Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O15217 T193 SIGNOR GSTA4 NILSAFPFLQEYTVKLsNIPtIKRFLEPGSKKKPPPDEIYV
O15350 S388 SIGNOR|PSP TP73 P73 LMKLKESLELMELVPQPLVDsYRQQQQLLQRPSHLQPPSYG
O15372 S183 Sugiyama EIF3H EIF3S3 SLKAYRLTPKLMEVCKEKDFsPEALKKANITFEYMFEEVPI
O15519 S193 SIGNOR|EPSD|PSP CFLAR CASH CASP8AP1 CLARP MRIT QSVQGAGTSYRNVLQAAIQKsLKDPSNNFRLHNGRSKEQRL
O60220 S94 Sugiyama TIMM8A DDP DDP1 TIM8A SQFILNRLEQTQKSKPVFSEsLsD_________________
O60488 T328 PSP ACSL4 ACS4 FACL4 LACS4 GLGPKDTYIGYLPLAHVLELtAEISCFTYGCRIGYssPLTL
O60814 S39 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
O60841 S196 Sugiyama EIF5B IF2 KIAA0741 ERsRINssGEsGDEsDEFLQsRKGQKKNQKNKPGPNIEsGN
O60841 S222 Sugiyama EIF5B IF2 KIAA0741 KNQKNKPGPNIEsGNEDDDAsFKIKTVAQKKAEKKERERKK
O60927 T75 Sugiyama PPP1R11 HCGV TCTE5 RRssKCCCIyEKPRAFGEsstEsDEEEEEGCGHtHCVRGHR
O75144 S285 SIGNOR ICOSLG B7H2 B7RP1 ICOSL KIAA0653 LLVVVAVAIGWVCRDRCLQHsYAGAWAVsPETELTGHV___
O75821 S217 Sugiyama EIF3G EIF3S4 PGELEPVQAtQNKtGKYVPPsLRDGAsRRGESMQPNRRADD
O94901 S113 SIGNOR SUN1 KIAA0810 UNC84A QRRSTNKSAFSINHVSRQVTsSGVSHGGTVSLQDAVTRRPP
O95243 S165 SIGNOR MBD4 MED1 VLSKRGIKSRYKDCSMAALTsHLQNQSNNSNWNLRTRSKCK
O95243 S262 SIGNOR MBD4 MED1 PIKKTKKGCRKsCSGFVQSDsKRESVCNKADAESEPVAQKS
O95678 S162 Sugiyama KRT75 K6HF KB18 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
O95832 T191 PSP CLDN1 CLD1 SEMP1 UNQ481/PRO944 AASLCLLGGALLCCSCPRKTtSYPTPRPYPKPAPSSGKDyV
O96004 S109 ELM HAND1 BHLHA27 EHAND GGRLGRRKGsGPKKERRRtEsINSAFAELRECIPNVPADTK
O96004 S98 ELM HAND1 BHLHA27 EHAND PGQSPGRLEALGGRLGRRKGsGPKKERRRtEsINSAFAELR
O96004 T107 ELM HAND1 BHLHA27 EHAND ALGGRLGRRKGsGPKKERRRtEsINSAFAELRECIPNVPAD
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00338 S167 Sugiyama LDHA PIG19 AWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVHPLSCHG
P00533 T678 ELM EGFR ERBB ERBB1 HER1 LVVALGIGLFMRRRHIVRKRtLRRLLQERELVEPLtPsGEA
P00558 T168 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 EAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGF
P01589 S268 ELM IL2RA FLLISVLLLSGLTWQRRQRKsRRtI________________
P01589 T271 ELM IL2RA ISVLLLSGLTWQRRQRKsRRtI___________________
P02538 S176 Sugiyama KRT6A K6A KRT6D IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P02545 S403 ELM LMNA LMN1 EEERLRLsPsPtsQRsRGRAssHssQtQGGGsVtKKRKLEs
P02545 S404 ELM LMNA LMN1 EERLRLsPsPtsQRsRGRAssHssQtQGGGsVtKKRKLEst
P02545 S5 ELM LMNA LMN1 ________________METPsQRRAtRsGAQAsstPLsPtR
P02545 S625 ELM LMNA LMN1 AQVGGPIssGssAssVtVtRsYRsVGGsGGGsFGDNLVtRS
P02545 T199 ELM LMNA LMN1 AKKQLQDEMLRRVDAENRLQtMKEELDFQKNIysEELREtK
P02545 T416 ELM LMNA LMN1 QRsRGRAssHssQtQGGGsVtKKRKLEstEsRssFsQHARt
P02545 T480 ELM LMNA LMN1 EDQsMGNWQIKRQNGDDPLLtYRFPPKFTLKAGQVVTIWAA
P02671 S576 ELM FGA NtKEsssHHPGIAEFPsRGKsssYSKQFTssTSYNRGDstF
P02671 S577 ELM FGA tKEsssHHPGIAEFPsRGKsssYSKQFTssTSYNRGDstFE
P02671 S578 ELM FGA KEsssHHPGIAEFPsRGKsssYSKQFTssTSYNRGDstFES
P02671 S618 ELM FGA SKSYKMADEAGsEADHEGTHsTKRGHAKSRPVRDCDDVLQT
P02786 S151 Sugiyama TFRC LsEKLDstDFTGtIKLLNENsyVPREAGsQKDENLALyVEN
P02786 S24 ELM TFRC QARsAFsNLFGGEPLsytRFsLARQVDGDNsHVEMKLAVDE
P02786 T143 Sugiyama TFRC yWDDLKRKLsEKLDstDFTGtIKLLNENsyVPREAGsQKDE
P04004 S381 SIGNOR|iPTMNet|EPSD VTN PRPsLAKKQRFRHRNRKGYRsQRGHsRGRNQNsRRPsRAtW
P04049 S497 SIGNOR RAF1 RAF HEGLtVKIGDFGLAtVKsRWsGsQQVEQPTGSVLWMAPEVI
P04049 S499 ELM RAF1 RAF GLtVKIGDFGLAtVKsRWsGsQQVEQPTGSVLWMAPEVIRM
P04049 S619 SIGNOR RAF1 RAF FPQILssIELLQHsLPKINRsAsEPsLHRAAHtEDINACtL
P04075 S336 Sugiyama ALDOA ALDA GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04083 S27 SIGNOR|ELM ANXA1 ANX1 LPC1 FLKQAWFIENEEQEyVQtVKssKGGPGsAVsPyPtFNPssD
P04083 S28 ELM|EPSD|PSP ANXA1 ANX1 LPC1 LKQAWFIENEEQEyVQtVKssKGGPGsAVsPyPtFNPssDV
P04083 T24 ELM ANXA1 ANX1 LPC1 VsEFLKQAWFIENEEQEyVQtVKssKGGPGsAVsPyPtFNP
P04259 S176 Sugiyama KRT6B K6B KRTL1 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04439 S359 ELM HLA-A HLAA RKGGsyTQAASSDSAQGSDVsLTACKV______________
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05107 S745 GPS6|SIGNOR|ELM|EPSD|PSP ITGB2 CD18 MFI7 ALIHLSDLREyRRFEKEKLKsQWNNDNPLFKsAtttVMNPK
P05107 S756 ELM ITGB2 CD18 MFI7 RRFEKEKLKsQWNNDNPLFKsAtttVMNPKFAES_______
P05107 T758 GPS6|SIGNOR|ELM|EPSD|PSP ITGB2 CD18 MFI7 FEKEKLKsQWNNDNPLFKsAtttVMNPKFAES_________
P05107 T760 ELM ITGB2 CD18 MFI7 KEKLKsQWNNDNPLFKsAtttVMNPKFAES___________
P05114 S21 ELM HMGN1 HMG14 MPKRKVssAEGAAKEEPKRRsARLsAKPPAKVEAKPKKAAA
P05114 S25 ELM HMGN1 HMG14 KVssAEGAAKEEPKRRsARLsAKPPAKVEAKPKKAAAKDKS
P05129 T514 Sugiyama PRKCG PKCG IKITDFGMCKENVFPGtTTRtFCGtPDyIAPEIIAyQPYGK
P05129 T518 Sugiyama PRKCG PKCG DFGMCKENVFPGtTTRtFCGtPDyIAPEIIAyQPYGKSVDW
P05455 S325 Sugiyama SSB VLEGEVEKEALKKIIEDQQEsLNKWKSKGRRFKGKGKGNKA
P05771 S16 SIGNOR|EPSD PRKCB PKCB PRKCB1 _____MADPAAGPPPsEGEEstVRFARKGALRQKNVHEVKN
P05771 S311 Sugiyama PRKCB PKCB PRKCB1 PPEGSEANEELRQKFERAKIsQGtKVPEEKTTNTVSKFDNN
P05771 S661 GPS6|SIGNOR|EPSD PRKCB PKCB PRKCB1 LtPtDKLFIMNLDQNEFAGFsyTNPEFVINV__________
P05771 T17 SIGNOR|EPSD PRKCB PKCB PRKCB1 ____MADPAAGPPPsEGEEstVRFARKGALRQKNVHEVKNH
P05771 T314 Sugiyama PRKCB PKCB PRKCB1 GSEANEELRQKFERAKIsQGtKVPEEKTTNTVSKFDNNGNR
P05771 T500 Sugiyama PRKCB PKCB PRKCB1 IKIADFGMCKENIWDGVttKtFCGtPDyIAPEIIAyQPYGK
P05771 T504 Sugiyama PRKCB PKCB PRKCB1 DFGMCKENIWDGVttKtFCGtPDyIAPEIIAyQPYGKSVDW
P05771 T635 GPS6|EPSD|Sugiyama PRKCB PKCB PRKCB1 PPYKPKARDKRDTSNFDKEFtRQPVELtPtDKLFIMNLDQN
P05771 T642 SIGNOR|Sugiyama PRKCB PKCB PRKCB1 RDKRDTSNFDKEFtRQPVELtPtDKLFIMNLDQNEFAGFsy
P05771 T83 Sugiyama PRKCB PKCB PRKCB1 QGFQCQVCCFVVHKRCHEFVtFsCPGADKGPASDDPRSKHK
P05783 S53 ELM KRT18 CYK18 PIG46 AsVyAGAGGsGsRIsVsRstsFRGGMGsGGLAtGIAGGLAG
P05787 S104 Sugiyama KRT8 CYK8 IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P06127 T434 SIGNOR|iPTMNet|EPSD CD5 LEU1 QRQWIGPTGMNQNMsFHRNHtAtVRsHAENPtASHVDNEys
P06127 T436 SIGNOR|iPTMNet|EPSD CD5 LEU1 QWIGPTGMNQNMsFHRNHtAtVRsHAENPtASHVDNEysQP
P06213 T1375 ELM INSR yEEHIPytHMNGGKKNGRILtLPRSNPS_____________
P06730 S209 SIGNOR|iPTMNet|EPSD EIF4E EIF4EL1 EIF4F LPPKIVIGyQsHADTAtKsGsttKNRFVV____________
P06748 S227 ELM NPM1 NPM SNQNGKDsKPsstPRsKGQEsFKKQEKtPKtPKGPssVEDI
P06899 S39 Sugiyama H2BC11 H2BFR HIST1H2BJ VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 S168 Sugiyama LDHB TWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIHPSSCHG
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07205 T168 Sugiyama PGK2 PGKB EAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNLPHKASGF
P07307 S12 ELM ASGR2 CLEC4H2 _________MAKDFQDIQQLsSEENDHPFHQGEGPGTRRLN
P07355 S2 SIGNOR|EPSD ANXA2 ANX2 ANX2L4 CAL1H LPC2D ___________________MstVHEILCKLsLEGDHstPPs
P07355 S26 ELM|EPSD|PSP ANXA2 ANX2 ANX2L4 CAL1H LPC2D EILCKLsLEGDHstPPsAyGsVKAytNFDAERDALNIEtAI
P07737 T65 Sugiyama PFN1 PAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQDGEFs
P07737 Y60 Sugiyama PFN1 FVNITPAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQ
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07864 S167 Sugiyama LDHC LDH3 LDHX VWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVHPTSCHG
P08034 S229 ELM GJB1 CX32 VVYLIIRACARRAQRRSNPPsRKGsGFGHRLSPEyKQNEIN
P08034 S233 ELM GJB1 CX32 IIRACARRAQRRSNPPsRKGsGFGHRLSPEyKQNEINKLLS
P08183 S661 ELM ABCB1 MDR1 PGY1 ADESKSEIDALEMssNDsRssLIRKRsTRRsVRGSQAQDRK
P08183 S667 ELM ABCB1 MDR1 PGY1 EIDALEMssNDsRssLIRKRsTRRsVRGSQAQDRKLsTKEA
P08183 S671 ELM ABCB1 MDR1 PGY1 LEMssNDsRssLIRKRsTRRsVRGSQAQDRKLsTKEALDES
P08195 S253 Sugiyama SLC3A2 MDU1 FQGHGAGNLAGLKGRLDyLssLKVKGLVLGPIHKNQKDDVA
P08195 S296 Sugiyama SLC3A2 MDU1 DLLQIDPNFGsKEDFDsLLQsAKKKSIRVILDLTPNYRGEN
P08238 S460 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ
P08567 S113 ELM PLEK P47 VRDIKKAIKCIEGGQKFARKstRRsIRLPEtIDLGALYLsM
P08567 S117 ELM PLEK P47 KKAIKCIEGGQKFARKstRRsIRLPEtIDLGALYLsMKDTE
P08567 T114 ELM PLEK P47 RDIKKAIKCIEGGQKFARKstRRsIRLPEtIDLGALYLsMK
P08581 S985 ELM MET GsELVRYDARVHtPHLDRLVsARsVsPttEMVsNEsVDyRA
P08729 S104 Sugiyama KRT7 SCL LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P09211 S185 SIGNOR GSTP1 FAEES3 GST3 VLAPGCLDAFPLLSAYVGRLsARPKLKAFLASPEyVNLPIN
P09211 S43 SIGNOR GSTP1 FAEES3 GST3 ADQGQSWKEEVVTVETWQEGsLKASCLyGQLPKFQDGDLtL
P09543 S9 ELM CNP ____________MNRGFsRKsHTFLPKIFFRKMsSSGAKDK
P09651 S360 Sugiyama HNRNPA1 HNRPA1 PyGGGGQyFAKPRNQGGyGGssssssyGsGRRF________
P09651 S362 Sugiyama HNRNPA1 HNRPA1 GGGGQyFAKPRNQGGyGGssssssyGsGRRF__________
P09651 S365 Sugiyama HNRNPA1 HNRPA1 GQyFAKPRNQGGyGGssssssyGsGRRF_____________
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P09651 Y366 Sugiyama HNRNPA1 HNRPA1 QyFAKPRNQGGyGGssssssyGsGRRF______________
P09693 S148 ELM CD3G T3G VLAVGVYFIAGQDGVRQsRAsDKQTLLPNDQLyQPLKDRED
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG47 S57 Sugiyama UBB PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0CG48 S57 Sugiyama UBC PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0DPH7 T334 Sugiyama TUBA3C TUBA2 ACCMLYRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
P11142 S340 Sugiyama HSPA8 HSC70 HSP73 HSPA10 ALRDAKLDKsQIHDIVLVGGstRIPKIQKLLQDFFNGKELN
P11171 S578 EPSD EPB41 E41P PtsAPAItQGQVAEGGVLDAsAKKTVVPKAQKETVKAEVKK
P11279 S335 Sugiyama LAMP1 DPAFKAANGSLRALQATVGNsYKCNAEEHVRVTKAFSVNIF
P11388 S29 SIGNOR|ELM|iPTMNet|EPSD TOP2A TOP2 VNENMQVNKIKKNEDAKKRLsVERIYQKKTQLEHILLRPDT
P11388 T1343 GPS6|ELM|EPSD TOP2A TOP2 KTKFTMDLDsDEDFsDFDEKtDDEDFVPsDAsPPKtKTsPK
P11473 S51 GPS6 VDR NR1I1 ATGFHFNAMTCEGCKGFFRRsMKRKALFTCPFNGDCRITKD
P12035 S211 Sugiyama KRT3 IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P13569 S686 ELM CFTR ABCC7 LHRFsLEGDAPVSWTEtKKQsFKQTGEFGEKRKNsILNPIN
P13569 S790 ELM CFTR ABCC7 LNLMTHSVNQGQNIHRKTTAsTRKVsLAPQANLTELDIYsR
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 S38 Sugiyama EEF2 EF2 NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13639 S593 Sugiyama EEF2 EF2 SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13647 S181 Sugiyama KRT5 IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13726 S285 ELM F3 ILVIILAISLHKCRKAGVGQsWKENsPLNVs__________
P13726 S290 ELM F3 LAISLHKCRKAGVGQsWKENsPLNVs_______________
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P13987 T76 Sugiyama CD59 MIC11 MIN1 MIN2 MIN3 MSK21 AGLQVYNKCWKFEHCNFNDVtTRLRENELtyyCCKKDLCNF
P14136 S13 ELM GFAP ________MERRRItsAARRsYVssGEMMVGGLAPGRRLGP
P14136 S17 ELM GFAP ____MERRRItsAARRsYVssGEMMVGGLAPGRRLGPGTRL
P14136 S38 ELM GFAP GEMMVGGLAPGRRLGPGTRLsLARMPPPLPTRVDFSLAGAL
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14598 S303 GPS6|SIGNOR|PSP NCF1 NOXO2 SH3PXD1A sGQDVsQAQRQIKRGAPPRRssIRNAHsIHQRsRKRLsQDA
P14598 S304 GPS6|SIGNOR|PSP NCF1 NOXO2 SH3PXD1A GQDVsQAQRQIKRGAPPRRssIRNAHsIHQRsRKRLsQDAY
P14598 S315 GPS6|SIGNOR|EPSD|PSP NCF1 NOXO2 SH3PXD1A KRGAPPRRssIRNAHsIHQRsRKRLsQDAYRRNsVRFLQQR
P14598 S320 GPS6|SIGNOR|PSP NCF1 NOXO2 SH3PXD1A PRRssIRNAHsIHQRsRKRLsQDAYRRNsVRFLQQRRRQAR
P14598 S328 GPS6|SIGNOR|PSP NCF1 NOXO2 SH3PXD1A AHsIHQRsRKRLsQDAYRRNsVRFLQQRRRQARPGPQsPGs
P14598 S359 GPS6|SIGNOR|PSP NCF1 NOXO2 SH3PXD1A ARPGPQsPGsPLEEERQtQRsKPQPAVPPRPsADLILNRCs
P14598 S370 GPS6|SIGNOR|EPSD|PSP NCF1 NOXO2 SH3PXD1A LEEERQtQRsKPQPAVPPRPsADLILNRCsESTKRKLASAV
P14598 S379 GPS6|SIGNOR|PSP NCF1 NOXO2 SH3PXD1A sKPQPAVPPRPsADLILNRCsESTKRKLASAV_________
P14618 S205 Sugiyama PKM OIP3 PK2 PK3 PKM2 VKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVsEKD
P14625 S680 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 RIMKAQAYQtGKDIstNyyAsQKKTFEINPRHPLIRDMLRR
P14679 S523 SIGNOR|EPSD|PSP TYR KRKQLPEEKQPLLMEKEDYHsLYQsHL______________
P14679 S527 SIGNOR|EPSD|PSP TYR LPEEKQPLLMEKEDYHsLYQsHL__________________
P15172 T115 ELM MYOD1 BHLHC1 MYF3 MYOD LWACKACKRKTTNADRRKAAtMRERRRLSKVNEAFETLKRC
P15336 S121 EPSD|PSP ATF2 CREB2 CREBP1 EDDIKKMPLDLsPLAtPIIRsKIEEPsVVEttHQDsPLPHP
P15336 S340 GPS6|EPSD ATF2 CREB2 CREBP1 tsttEtPAsPAHttPQtQstsGRRRRAANEDPDEKRRKFLE
P15336 S367 GPS6|EPSD ATF2 CREB2 CREBP1 ANEDPDEKRRKFLERNRAAAsRCRQKRKVWVQSLEKKAEDL
P15382 S102 PSP KCNE1 IESDAWQEKDKAYVQARVLEsYRSCYVVENHLAIEQPNTHL
P15880 S190 Sugiyama RPS2 RPS4 WGNKIGKPHTVPCKVTGRCGsVLVRLIPAPRGtGIVsAPVP
P16070 S291 ELM CD44 LHR MDU2 MDU3 MIC4 TISAGWEPNEENEDERDRHLsFSGSGIDDDEDFISSTISTT
P16949 S25 SIGNOR|EPSD|PSP STMN1 C1orf215 LAP18 OP18 DIQVKELEKRAsGQAFELILsPRsKEsVPEFPLsPPKKKDL
P16949 S38 SIGNOR|EPSD|PSP STMN1 C1orf215 LAP18 OP18 QAFELILsPRsKEsVPEFPLsPPKKKDLsLEEIQKKLEAAE
P17252 T497 Sugiyama PRKCA PKCA PRKACA IKIADFGMCKEHMMDGVttRtFCGtPDyIAPEIIAyQPYGK
P17252 T501 Sugiyama PRKCA PKCA PRKACA DFGMCKEHMMDGVttRtFCGtPDyIAPEIIAyQPYGKSVDW
P17252 T83 Sugiyama PRKCA PKCA PRKACA QGFQCQVCCFVVHKRCHEFVtFsCPGADKGPDTDDPRSKHK
P17302 S368 SIGNOR|iPTMNet|EPSD GJA1 GJAL AAGHELQPLAIVDQRPssRAssRAssRPRPDDLEI______
P17677 S41 SIGNOR|iPTMNet|EPSD GAP43 EQDGIKPEDKAHKAATKIQAsFRGHITRKKLKGEKKDDVQA
P17844 S557 ELM DDX5 G17P1 HELR HLR1 AANYTNGSFGSNFVSAGIQTsFRTGNPtGTYQNGYDSTQQY
P18031 S378 ELM PTPN1 PTP1B PYGIEsMsQDtEVRSRVVGGsLRGAQAAsPAKGEPsLPEKD
P18505 S434 ELM GABRB1 YGRALDRHGVPSKGRIRRRAsQLKVKIPDLTDVNSIDKWSR
P18507 S366 ELM GABRG2 VFSALVEYGTLHYFVSNRKPsKDKDKKKKNPLLRMFSFKAP
P18615 S131 Sugiyama NELFE RD RDBP QRsIsADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGE
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P18669 S14 Sugiyama PGAM1 PGAMA CDABP0006 _______MAAYKLVLIRHGEsAWNLENRFsGWyDADLsPAG
P19021 S929 ELM PAM VLGRFRGKGsGGLNLGNFFAsRKGYsRKGFDRLstEGsDQE
P19021 S934 ELM PAM RGKGsGGLNLGNFFAsRKGYsRKGFDRLstEGsDQEKEDDG
P19086 S16 ELM GNAZ _____MGCRQSSEEKEAARRsRRIDRHLRSEsQRQRREIKL
P19086 S27 ELM GNAZ SEEKEAARRsRRIDRHLRSEsQRQRREIKLLLLGTSNSGKS
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19429 S42 SIGNOR TNNI3 TNNC1 RssNyRAYAtEPHAKKKsKIsAsRKLQLKtLLLQIAKQELE
P19429 S44 SIGNOR TNNI3 TNNC1 sNyRAYAtEPHAKKKsKIsAsRKLQLKtLLLQIAKQELERE
P19429 T143 SIGNOR TNNI3 TNNC1 TEIADLtQKIFDLRGKFKRPtLRRVRIsADAMMQALLGARA
P19484 S466 SIGNOR TFEB BHLHE35 ASDPLLstMsPEAsKAssRRssFsMEEGDVL__________
P19484 S467 SIGNOR TFEB BHLHE35 SDPLLstMsPEAsKAssRRssFsMEEGDVL___________
P20618 S157 Sugiyama PSMB1 PSC5 IIGGLDEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLL
P20618 S162 Sugiyama PSMB1 PSC5 DEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLLDNQVG
P20700 S395 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP LMNB1 LMN2 LMNB sAYRKLLEGEEERLKLsPsPssRVtVsRAsssRsVRTTRGK
P20700 S396 ELM LMNB1 LMN2 LMNB AYRKLLEGEEERLKLsPsPssRVtVsRAsssRsVRTTRGKR
P20700 S405 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP LMNB1 LMN2 LMNB EERLKLsPsPssRVtVsRAsssRsVRTTRGKRKRVDVEESE
P20700 S406 ELM LMNB1 LMN2 LMNB ERLKLsPsPssRVtVsRAsssRsVRTTRGKRKRVDVEESEA
P21730 S334 SIGNOR|EPSD|PSP C5AR1 C5AR C5R1 sLPsLLRNVLTEEsVVREsKsFTRsTVDTMAQKTQAV____
P22059 S190 Sugiyama OSBP OSBP1 QRWVTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNT
P22059 S193 Sugiyama OSBP OSBP1 VTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNTLRT
P23246 S283 Sugiyama SFPQ PSF GPGGRsEEKIsDsEGFKANLsLLRRPGEKTyTQRCRLFVGN
P23396 T220 Sugiyama RPS3 OK/SW-cl.26 PKKPLPDHVsIVEPKDEILPttPIsEQKGGKPEPPAMPQPV
P23396 T221 Sugiyama RPS3 OK/SW-cl.26 KKPLPDHVsIVEPKDEILPttPIsEQKGGKPEPPAMPQPVP
P23527 S39 Sugiyama H2BC17 H2BFH H2BFN HIST1H2BO VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA
P23677 T311 ELM ITPKA KMLAVDPEAPTEEEHAQRAVtKPRYMQWREGISSSTTLGFR
P24941 T160 Sugiyama CDK2 CDKN2 AIKLADFGLARAFGVPVRtytHEVVtLWyRAPEILLGCKYY
P25789 T10 Sugiyama PSMA4 HC9 PSC9 ___________MSRRyDsRttIFsPEGRLYQVEYAMEAIGH
P25789 Y5 Sugiyama PSMA4 HC9 PSC9 ________________MSRRyDsRttIFsPEGRLYQVEYAM
P26010 T783 SIGNOR|iPTMNet|EPSD ITGB7 KEQQQLNWKQDsNPLYKSAItttINPRFQEADSPTL_____
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P27348 S63 Sugiyama YWHAQ LLsVAyKNVVGGRRSAWRVIsSIEQKTDTSDKKLQLIKDYR
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P27824 S583 ELM|Sugiyama CANX VsQEEEDRKPKAEEDEILNRsPRNRKPRRE___________
P28329 S464 SIGNOR|EPSD CHAT PFDGIVLVQCTEHLLKHVTQssRKLIRADsVSELPAPRRLR
P28329 S465 SIGNOR|EPSD CHAT FDGIVLVQCTEHLLKHVTQssRKLIRADsVSELPAPRRLRW
P28329 S558 SIGNOR|EPSD CHAT ALQLAFYRLHRRLVPTYESAsIRRFQEGRVDNIRSAtPEAL
P28329 S594 SIGNOR|EPSD CHAT tPEALAFVRAVTDHKAAVPAsEKLLLLKDAIRAQTAYTVMA
P28329 T373 SIGNOR|EPSD CHAT LTSDGRSEWAEARTVLVKDStNRDSLDMIERCICLVCLDAP
P28799 S81 EPSD|PSP GRN CQVDAHCSAGHSCIFTVSGTsSCCPFPEAVACGDGHHCCPR
P29317 S892 PSP EPHA2 ECK DKLIRAPDSLKTLADFDPRVsIRLPstsGsEGVPFRTVsEW
P29353 S139 EPSD|PSP SHC1 SHC SHCA GRRTRVEGGQLGGEEWTRHGsFVNKPTRGWLHPNDKVMGPG
P29353 S213 EPSD|PSP SHC1 SHC SHCA SLVCEAVPGAKGAtRRRKPCsRPLSSILGRSNLKFAGMPIT
P29353 T206 EPSD|PSP SHC1 SHC SHCA QVTREAISLVCEAVPGAKGAtRRRKPCsRPLSSILGRSNLK
P29474 T495 SIGNOR NOS3 YQPDPWKGSAAKGTGITRKKtFKEVANAVKISASLMGTVMA
P29966 S159 SIGNOR|ELM|iPTMNet|EPSD|PSP MARCKS MACS PRKCSL EDGAtPsPsNEtPKKKKKRFsFKKsFKLsGFsFKKNKKEAG
P29966 S163 SIGNOR|ELM|iPTMNet|EPSD|PSP MARCKS MACS PRKCSL tPsPsNEtPKKKKKRFsFKKsFKLsGFsFKKNKKEAGEGGE
P29966 S167 ELM MARCKS MACS PRKCSL sNEtPKKKKKRFsFKKsFKLsGFsFKKNKKEAGEGGEAEAP
P29966 S170 SIGNOR|ELM|iPTMNet|EPSD MARCKS MACS PRKCSL tPKKKKKRFsFKKsFKLsGFsFKKNKKEAGEGGEAEAPAAE
P29972 T157 ELM AQP1 CHIP28 QGLGIEIIGTLQLVLCVLATtDRRRRDLGGSAPLAIGLSVA
P29972 T239 ELM AQP1 CHIP28 GGALAVLIYDFILAPRSSDLtDRVKVWtsGQVEEyDLDADD
P30086 S153 iPTMNet|EPSD PEBP1 PBP PEBP CDEPILsNRsGDHRGKFKVAsFRKKyELRAPVAGtCyQAEW
P30101 T485 Sugiyama PDIA3 ERP57 ERP60 GRP58 KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P30273 S69 EPSD|PSP FCER1G QVRKAAITSyEKsDGVytGLsTRNQEtyEtLKHEKPPQ___
P30411 S373 ELM BDKRB2 BKR2 KGGCRSEPIQMENsMGTLRTsIsVERQIHKLQDWAGSRQ__
P30622 S204 Sugiyama CLIP1 CYLN1 RSN PISNLTKtAsEsIsNLsEAGsIKKGERELKIGDRVLVGGTK
P30679 S336 ELM GNA15 GNA16 YTRMYTGCVDGPEGsKKGARsRRLFSHYTCATDTQNIRKVF
P31749 S473 EPSD|PSP AKT1 PKB RAC DQDDSMECVDSERRPHFPQFsysAsGtA_____________
P31749 T308 EPSD|PSP AKT1 PKB RAC IKITDFGLCKEGIKDGAtMKtFCGtPEyLAPEVLEDNDyGR
P31946 S65 Sugiyama YWHAB LLsVAyKNVVGARRSsWRVIsSIEQKTERNEKKQQMGKEYR
P32119 T142 Sugiyama PRDX2 NKEFB TDPX1 EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P33176 S57 Sugiyama KIF5B KNS KNS1 DTVVIASKPYAFDRVFQSsTsQEQVyNDCAKKIVKDVLEGy
P33778 S39 Sugiyama H2BC3 H2BFF HIST1H2BB ITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISSKA
P34741 S187 SIGNOR|ELM|iPTMNet|EPSD SDC2 HSPG1 LVYRMRKKDEGsyDLGERKPssAAYQKAPTKEFYA______
P34741 S188 SIGNOR|ELM|iPTMNet|EPSD SDC2 HSPG1 VYRMRKKDEGsyDLGERKPssAAYQKAPTKEFYA_______
P35221 S641 Sugiyama CTNNA1 GIRDIRKAVLMIRtPEELDDsDFEtEDFDVRsRtsVQtEDD
P35221 T634 Sugiyama CTNNA1 ASRLVyDGIRDIRKAVLMIRtPEELDDsDFEtEDFDVRsRt
P35408 S259 ELM PTGER4 PTGER2 RGHPAAsPALPRLSDFRRRRsFRRIAGAEIQMVILLIATSL
P35408 S354 ELM PTGER4 PTGER2 KTVLSKAIEKIKCLFCRIGGsRRERSGQHCSDSQRTSSAMs
P35408 S430 ELM PTGER4 PTGER2 GGRNLLPGVPGMGLAQEDttsLRtLRISETSDSSQGQDSES
P35408 S460 ELM PTGER4 PTGER2 SDSSQGQDSESVLLVDEAGGsGRAGPAPKGSSLQVTFPSET
P35408 S484 ELM PTGER4 PTGER2 GPAPKGSSLQVTFPSETLNLsEKCI________________
P35408 T433 ELM PTGER4 PTGER2 NLLPGVPGMGLAQEDttsLRtLRISETSDSSQGQDSESVLL
P35548 T135 EPSD|PSP MSX2 HOX8 WMQEPGRYsPPPRHMSPTTCtLRKHKtNRKPRTPFTTSQLL
P35548 T141 EPSD|PSP MSX2 HOX8 RYsPPPRHMSPTTCtLRKHKtNRKPRTPFTTSQLLALERKF
P35568 S323 EPSD|PSP IRS1 sRtEsItAtsPAsMVGGKPGsFRVRAssDGEGtMsRPAsVD
P35568 S441 EPSD|PSP IRS1 SDGGFISSDEYGSSPCDFRSsFRsVtPDsLGHtPPARGEEE
P35579 S1916 GPS6|ELM|PSP MYH9 LQRELEDAtEtADAMNREVssLKNKLRRGDLPFVVPRRMAR
P35612 S713 ELM ADD2 ADDB sPEGsPsKsPsKKKKKFRTPsFLKKSKKKEKVEs_______
P35612 S726 ELM ADD2 ADDB KKKFRTPsFLKKSKKKEKVEs____________________
P35637 S257 GPS6|ELM|EPSD|PSP FUS TLS GGYEPRGRGGGRGGRGGMGGsDRGGFNKFGGPRDQGsRHDs
P35908 S191 Sugiyama KRT2 KRT2A KRT2E IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P37108 S25 Sugiyama SRP14 EsEQFLtELTRLFQKCRTSGsVyItLKKYDGRTKPIPKKGt
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P38646 T120 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P38646 Y118 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 ERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIK
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39023 S265 Sugiyama RPL3 OK/SW-cl.32 HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P40818 S719 Sugiyama USP8 KIAA0055 UBPY KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P41143 S344 ELM OPRD1 OPRD NFKRCFRQLCRKPCGRPDPSsFSRAREATARERVtACtPsD
P41180 T888 SIGNOR|ELM|iPTMNet|EPSD CASR GPRC2A PCAR1 TIEEVRCsTAAHAFKVAARAtLRRsNVsRKRsssLGGSTGS
P41594 S840 SIGNOR|iPTMNet|EPSD GRM5 GPRC1E MGLUR5 PKVYIILAKPERNVRSAFTTstVVRMHVGDGKSSSAASRSS
P41594 T841 SIGNOR GRM5 GPRC1E MGLUR5 KVYIILAKPERNVRSAFTTstVVRMHVGDGKSSSAASRSSS
P42261 S849 ELM GRIA1 GLUA1 GLUH1 GLUR1 CYKsRsEsKRMKGFCLIPQQsINEAIRTStLPRNsGAGASS
P42677 S11 Sugiyama RPS27 MPS1 __________MPLAKDLLHPsPEEEKRKHKKKRLVQsPNsy
P42677 S78 Sugiyama RPS27 MPS1 GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P43629 S415 SIGNOR|PSP KIR3DL1 CD158E NKAT3 NKB1 EVTYAQLDHCVFTQRKITRPsQRPKtPPTDTILYTELPNAK
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777 S176 Sugiyama RPL5 MSTP030 GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46777 T177 Sugiyama RPL5 MSTP030 NKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHRK
P46779 S115 Sugiyama RPL28 HMIRKNKYRPDLRMAAIRRAsAILRSQKPVMVKRKRTRPTK
P46783 S146 Sugiyama RPS10 TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P46937 S109 Sugiyama YAP1 YAP65 RKLPDsFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssP
P47712 S727 Sugiyama PLA2G4A CPLA2 PLA2G4 VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P47756 S192 Sugiyama CAPZB TVMLWLQTNKSGsGtMNLGGsLtRQMEKDEtVsDCsPHIAN
P48048 S201 SIGNOR KCNJ1 ROMK1 KIsRPKKRAKtItFSKNAVIsKRGGKLCLLIRVANLRKsLL
P48048 S4 SIGNOR KCNJ1 ROMK1 _________________MNAsSRNVFDTLIRVLTESMFKHL
P48058 S862 ELM GRIA4 GluA4 GLUR4 AEAKRMKLtFSEAIRNKARLsITGSVGENGRVLTPDCPKAV
P48058 T850 ELM GRIA4 GluA4 GLUR4 LVALIEFCYKSRAEAKRMKLtFSEAIRNKARLsITGSVGEN
P48668 S176 Sugiyama KRT6C KRT6E IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P48736 S582 SIGNOR|EPSD|PSP PIK3CG DPLNPLTAEDKELLWHFRYEsLKHPKAYPKLFSSVKWGQQE
P49327 S207 Sugiyama FASN FAS GINVLLKPNTSVQFLRLGMLsPEGtCKAFDtAGNGYCRSEG
P49768 S346 SIGNOR PSEN1 AD3 PS1 PSNL1 DtVAENDDGGFsEEWEAQRDsHLGPHRstPEsRAAVQELss
P49795 T201 ELM RGS19 GAIP GNAI3IP QLQIYTLMHRDSYPRFLSSPtYRALLLQGPSQsssEA____
P49840 S21 SIGNOR|ELM|iPTMNet|EPSD|PSP GSK3A MsGGGPsGGGPGGsGRARtssFAEPGGGGGGGGGGPGGsAs
P49841 S9 EPSD|PSP GSK3B ____________MSGRPRttsFAEsCKPVQQPsAFGsMKVS
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51811 S63 ELM XK XKR1 XRG1 FSLLPCALVQLTLLFVHRDLsRDRPLVLLLHLLQLGPLFRC
P51991 S375 Sugiyama HNRNPA3 HNRPA3 ssGsPyGGGyGsGGGsGGyGsRRF_________________
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P55042 S214 SIGNOR|iPTMNet|EPSD RRAD RAD DDVPIILVGNKSDLVRSREVsVDEGRACAVVFDCKFIETSA
P55042 S257 SIGNOR|iPTMNet|EPSD RRAD RAD HHNVQALFEGVVRQIRLRRDsKEANARRQAGTRRREsLGKK
P55042 S273 SIGNOR RRAD RAD LRRDsKEANARRQAGTRRREsLGKKAKRFLGRIVARNsRKM
P55042 S290 SIGNOR|iPTMNet|EPSD RRAD RAD RREsLGKKAKRFLGRIVARNsRKMAFRAKsKsCHDLSVL__
P55042 S299 SIGNOR|iPTMNet|EPSD RRAD RAD KRFLGRIVARNsRKMAFRAKsKsCHDLSVL___________
P55087 S180 SIGNOR AQP4 LLVELIITFQLVFTIFASCDsKRTDVTGSIALAIGFSVAIG
P55209 T269 Sugiyama NAP1L1 NRP GPEIMGCTGCQIDWKKGKNVtLKtIKKKQKHKGRGTVRTVT
P55209 T272 Sugiyama NAP1L1 NRP IMGCTGCQIDWKKGKNVtLKtIKKKQKHKGRGTVRTVTKTV
P56537 S235 SIGNOR|PSP EIF6 EIF3A ITGB4BP OK/SW-cl.27 LSVVESVFKLNEAQPstIAtsMRDsLIDsLt__________
P56537 T234 EPSD EIF6 EIF3A ITGB4BP OK/SW-cl.27 ELSVVESVFKLNEAQPstIAtsMRDsLIDsLt_________
P57053 S39 Sugiyama H2BC12L H2BFS H2BS1 VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P58876 S39 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60174 T217 Sugiyama TPI1 TPI VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 S60 Sugiyama ACTB HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61081 S175 Sugiyama UBE2M UBC12 NNRRLFEQNVQRSMRGGyIGstyFERCLK____________
P61247 S236 Sugiyama RPS3A FTE1 MFTL KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61254 S9 Sugiyama RPL26 ____________MKFNPFVtsDRsKNRKRHFNAPsHIRRKI
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61764 S306 SIGNOR|iPTMNet|EPSD STXBP1 UNC18A DLWIALRHKHIAEVSQEVTRsLKDFSSsKRMNTGEKTTMRD
P61764 S313 SIGNOR|iPTMNet|EPSD STXBP1 UNC18A HKHIAEVSQEVTRsLKDFSSsKRMNTGEKTTMRDLSQMLKK
P61978 S401 Sugiyama HNRNPK HNRPK GDLGGPIIttQVtIPKDLAGsIIGKGGQRIKQIRHEsGAsI
P61978 S417 Sugiyama HNRNPK HNRPK DLAGsIIGKGGQRIKQIRHEsGAsIKIDEPLEGsEDRIITI
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981 S64 Sugiyama YWHAG LLsVAyKNVVGARRSsWRVIsSIEQKtsADGNEKKIEMVRA
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62263 S139 Sugiyama RPS14 PRO2640 LARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL________
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280 T15 Sugiyama RPS11 ______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62280 T54 Sugiyama RPS11 PRYYKNIGLGFKtPKEAIEGtyIDKKCPFTGNVsIRGRILs
P62304 S89 Sugiyama SNRPE KSRKQLGRIMLKGDNITLLQsVsN_________________
P62491 S177 SIGNOR|PSP RAB11A RAB11 DSTNVEAAFQTILTEIYRIVsQKQMSDRRENDMsPsNNVVP
P62701 T247 Sugiyama RPS4X CCG2 RPS4 SCAR VIGKGNKPWIsLPRGKGIRLtIAEERDKRLAAKQSSG____
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 S62 Sugiyama ACTA2 ACTSA ACTVS GIG46 HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62807 S39 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA
P62857 S41 Sugiyama RPS28 tGsQGQCtQVRVEFMDDtsRsIIRNVKGPVREGDVLtLLEs
P62899 T119 Sugiyama RPL31 PNKLytLVtyVPVttFKNLQtVNVDEN______________
P62899 T26 Sugiyama RPL31 KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62906 T9 Sugiyama RPL10A NEDD6 ____________MSSKVsRDtLyEAVREVLHGNQRKRRKFL
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 S14 Sugiyama RPL8 _______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62979 S57 Sugiyama RPS27A UBA80 UBCEP1 PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGA
P62987 S57 Sugiyama UBA52 UBCEP2 PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGI
P63173 T14 Sugiyama RPL38 _______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63220 S31 Sugiyama RPS21 LYVPRKCSASNRIIGAKDHAsIQMNVAEVDKVTGRFNGQFK
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 S60 Sugiyama ACTG1 ACTG HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 S61 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P67809 S136 Sugiyama YBX1 NSEP1 YB1 GEKGAEAANVtGPGGVPVQGsKYAADRNHYRRYPRRRGPPR
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 S62 Sugiyama ACTC1 ACTC HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68104 S53 SIGNOR EEF1A1 EEF1A EF1A LENG7 GIDKRTIEKFEKEAAEMGKGsFKYAWVLDKLKAERERGITI
P68104 T432 ELM|Sugiyama EEF1A1 EEF1A EF1A LENG7 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 S62 Sugiyama ACTA1 ACTA HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68363 T334 Sugiyama TUBA1B ACCLLyRGDVVPKDVNAAIAtIKtKRsIQFVDWCPTGFKVG
P68431 T7 EPSD H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J ______________MARtKQtARKstGGKAPRKQLATKAAR
P78417 S23 Sugiyama GSTO1 GSTTLP28 GESARsLGKGsAPPGPVPEGsIRIySMRFCPFAERTRLVLK
P83731 S7 Sugiyama RPL24 ______________MKVELCsFsGyKIYPGHGRRYARTDGK
P83731 S86 Sugiyama RPL24 EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P98082 S24 SIGNOR|ELM|iPTMNet|EPSD|PSP DAB2 DOC2 EVEtSATNGQPDQQAAPKAPsKKEKKKGPEKTDEyLLARFK
Q00341 S904 Sugiyama HDLBP HBP VGL FHRSVMGPKGSRIQQITRDFsVQIKFPDREENAVHSTEPVV
Q00526 T160 Sugiyama CDK3 CDKN3 AIKLADFGLARAFGVPLRtYtHEVVTLWYRAPEILLGSKFY
Q00610 S146 Sugiyama CLTC CLH17 CLTCL2 KIAA0034 AVYHWSMEGESQPVKMFDRHssLAGCQIINYRTDAKQKWLL
Q01546 S196 Sugiyama KRT76 KRT2B KRT2P IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q01844 S266 SIGNOR|ELM EWSR1 EWS SYSQAPSQYSQQSSSYGQQSsFRQDHPssMGVyGQESGGFS
Q01970 S1105 GPS6 PLCB3 EMNEREKKELQKILDRKRHNsIsEAKMRDKHKKEAELTEIN
Q01995 S181 ELM TAGLN SM22 WS3-10 REFtEsQLQEGKHVIGLQMGsNRGAsQAGMTGYGRPRQIIS
Q02543 S123 Sugiyama RPL18A AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK
Q02790 T42 Sugiyama FKBP4 FKBP52 GVDIsPKQDEGVLKVIKREGtGTEMPMIGDRVFVHYTGWLL
Q03721 S15 GPS6|SIGNOR|ELM|EPSD|PSP KCNC4 C1orf30 ______MISSVCVssYRGRKsGNKPPsKTCLKEEMAKGEAS
Q03721 S21 GPS6|SIGNOR|ELM|EPSD|PSP KCNC4 C1orf30 MISSVCVssYRGRKsGNKPPsKTCLKEEMAKGEASEKIIIN
Q03721 S8 GPS6|ELM|EPSD|PSP KCNC4 C1orf30 _____________MISSVCVssYRGRKsGNKPPsKTCLKEE
Q03721 S9 GPS6|ELM|EPSD|PSP KCNC4 C1orf30 ____________MISSVCVssYRGRKsGNKPPsKTCLKEEM
Q04917 S64 Sugiyama YWHAH YWHA1 LLsVAyKNVVGARRSsWRVIsSIEQKTMADGNEKKLEKVKA
Q05209 S39 ELM PTPN12 sPDHNGEDNFARDFMRLRRLsTKYRTEKIyPTATGEKEENV
Q05209 S435 ELM PTPN12 LPGKNESTIEQIDKKLERNLsFEIKKVPLQEGPKsFDGNtL
Q05586 S889 ELM GRIN1 NMDAR1 RAEPDPKKKATFRAITSTLAssFKRRRssKDTSTGGGRGAL
Q05586 S890 ELM GRIN1 NMDAR1 AEPDPKKKATFRAITSTLAssFKRRRssKDTSTGGGRGALQ
Q05586 S896 ELM GRIN1 NMDAR1 KKATFRAITSTLAssFKRRRssKDTSTGGGRGALQNQKDTV
Q05586 S897 ELM GRIN1 NMDAR1 KATFRAITSTLAssFKRRRssKDTSTGGGRGALQNQKDTVL
Q05639 S53 SIGNOR EEF1A2 EEF1AL STN GIDKRTIEKFEKEAAEMGKGsFKYAWVLDKLKAERERGITI
Q05639 T432 Sugiyama EEF1A2 EEF1AL STN VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q06124 S576 SIGNOR|PSP PTPN11 PTP2C SHPTP2 DQSPLPPCTPTPPCAEMREDsARVyENVGLMQQQKsFR___
Q06124 S591 PSP PTPN11 PTP2C SHPTP2 EMREDsARVyENVGLMQQQKsFR__________________
Q06187 S180 GPS6|SIGNOR|iPTMNet|EPSD BTK AGMX1 ATK BPK KNAMGCQILENRNGSLKPGSsHRKtKKPLPPtPEEDQILKK
Q06210 S261 Sugiyama GFPT1 GFAT GFPT GsQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDA
Q06481 T723 ELM APLP2 APPL2 VAIATVIVISLVMLRKRQYGtISHGIVEVDPMLtPEERHLN
Q06830 T143 Sugiyama PRDX1 PAGA PAGB TDPX2 EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q07020 T136 Sugiyama RPL18 AGGKILtFDQLALDsPKGCGtVLLsGPRKGREVYRHFGKAP
Q07020 T85 Sugiyama RPL18 RMIRKMKLPGRENKtAVVVGtItDDVRVQEVPKLKVCALRV
Q07869 S179 GPS6|PSP PPARA NR1C1 PPAR HKCLSVGMSHNAIRFGRMPRsEKAKLKAEILTCEHDIEDSE
Q07869 S230 GPS6|PSP PPARA NR1C1 PPAR IYEAYLKNFNMNKVKARVILsGKASNNPPFVIHDMETLCMA
Q12906 S647 SIGNOR|EPSD|PSP ILF3 DRBF MPHOSPH4 NF90 GPMHNEVPPPPNLRGRGRGGsIRGRGRGRGFGGANHGGYMN
Q13131 S496 SIGNOR|EPSD|PSP PRKAA1 AMPK1 sIDDEItEAKsGtAtPQRsGsVsNYRSCQRsDsDAEAQGKs
Q13224 S1303 SIGNOR|iPTMNet|EPSD GRIN2B NMDAR2B QSPTNSKAQKKNRNKLRRQHsYDTFVDLQKEEAALAPRSVs
Q13224 S1323 SIGNOR|iPTMNet|EPSD GRIN2B NMDAR2B sYDTFVDLQKEEAALAPRSVsLKDKGRFMDGSPyAHMFEMS
Q13255 T695 ELM GRM1 GPRC1A MGLUR1 LVTKTNRIARILAGSKKKICtRKPRFMSAWAQVIIASILIS
Q13887 S153 ELM KLF5 BTEB2 CKLF IKLF SINMNVFLPDITHLRTGLYKsQRPCVTHIKTEPVAIFSHQS
Q14004 S389 Sugiyama CDK13 CDC2L CDC2L5 CHED KIAA1791 SYSRHSSYERGGDVsPsPyssSsWRRsRsPysPVLRRSGKS
Q14152 S1364 PSP EIF3A EIF3S10 KIAA0139 DREREGEKEKASWRAEKDREsLRRTKNEtDEDGWttVRR__
Q14152 S988 Sugiyama EIF3A EIF3S10 KIAA0139 PRRGPEEDRFsRRGADDDRPsWRNTDDDRPPRRIADEDRGN
Q14152 T1379 Sugiyama EIF3A EIF3S10 KIAA0139 EKDREsLRRTKNEtDEDGWttVRR_________________
Q14155 S518 Sugiyama ARHGEF7 COOL1 KIAA0142 P85SPR PAK3BP PIXB Nbla10314 ERYLLLFPNVLLMLSASPRMsGFIyQGKLPtTGMTITKLED
Q14244 S282 Sugiyama MAP7 AAHSRNsMDRPKLFVtPPEGssRRRIIHGTAsYKKEREREN
Q14469 S37 ELM HES1 BHLHB39 HL HRY tPAsVNttPDKPKTASEHRKssKPIMEKRRRARINESLSQL
Q14469 S38 ELM HES1 BHLHB39 HL HRY PAsVNttPDKPKTASEHRKssKPIMEKRRRARINESLSQLK
Q14847 S146 SIGNOR LASP1 MLN50 FEKSRMGPsGGEGMEPERRDsQDGssyRRPLEQQQPHHIPt
Q14CN4 S138 Sugiyama KRT72 K6IRS2 KB35 KRT6 KRT6IRS2 IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15021 S1310 Sugiyama NCAPD2 CAPD2 CNAP1 KIAA0159 RACHTRGLDGIKELEIGQAGsQRAPsAKKPSTGSRyQPLAs
Q15052 S488 Sugiyama ARHGEF6 COOL2 KIAA0006 PIXA ERYLMLFSNVLIMLSASPRMsGFIYQGKIPIAGTVVTRLDE
Q15052 S640 SIGNOR ARHGEF6 COOL2 KIAA0006 PIXA sKsPKTMKKFLHKRKTERKPsEEEyVIRKstAALEEDAQIL
Q15052 S684 SIGNOR ARHGEF6 COOL2 KIAA0006 PIXA EAYCTSANFQQGHGsstRKDsIPQVLLPEEEKLIIEETRsN
Q15080 T154 ELM NCF4 SH3PXD4 YQSPYDSEQVPQALRRLRPRtRKVKsVsPQGNsVDRMAAPR
Q15121 S104 ELM PEA15 TRVLKIsEEDELDtKLtRIPsAKKYKDIIRQPsEEEIIKLA
Q15139 S249 ELM PRKD1 PKD PKD1 PRKCM EPLLQKsPsEsFIGREKRsNsQsyIGRPIHLDKILMSKVKV
Q15185 S113 Sugiyama PTGES3 P23 TEBP RAKLNWLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGD
Q15438 S394 ELM CYTH1 D17S811E PSCD1 AAISRDPFYEMLAARKKKVSstKRH________________
Q15438 T395 ELM CYTH1 D17S811E PSCD1 AISRDPFYEMLAARKKKVSstKRH_________________
Q15906 S132 ELM VPS72 TCFL1 YL1 REEKALLPLELQDDGsDsRKsMRQStAEHTRQTFLRVQERQ
Q16236 S40 SIGNOR|ELM NFE2L2 NRF2 IDILWRQDIDLGVSREVFDFsQRRKEYELEKQKKLEKERQE
Q16625 S340 SIGNOR|ELM|iPTMNet|EPSD OCLN DsPMAYSsNGKVNDKRFYPEssyKstPVPEVVQELPLtsPV
Q16625 S490 EPSD|PSP OCLN EsEEyMAAADEYNRLKQVKGsADYKSKKNHCKQLKSKLSHI
Q16658 S39 ELM FSCN1 FAN1 HSN SNL CGNKyLTAEAFGFKVNASAssLKKKQIWTLEQPPDEAGSAA
Q16778 S39 Sugiyama H2BC21 H2BFQ HIST2H2BE VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIssKA
Q16820 S687 SIGNOR|ELM MEP1B MLIITLVSVYCTRKKYRERMsSNRPNLTPQNQHAF______
Q16831 S61 Sugiyama UPP1 UP TSRHNFPALFGDVKFVCVGGsPsRMKAFIRCVGAELGLDCP
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q3SY84 S143 Sugiyama KRT71 K6IRS1 KB34 KRT6IRS1 IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q3ZCM7 S75 Sugiyama TUBB8 SGGRYVPRAVLVDLEPGtMDsVRSGPFGQVFRPDNFIFGQC
Q5JVS0 T354 SIGNOR|iPTMNet|EPSD HABP4 MVKDDYEDDSHVFRKPANDItSQLEINFGNLPRPGRGARGG
Q5JVS0 T375 SIGNOR|iPTMNet|EPSD HABP4 SQLEINFGNLPRPGRGARGGtRGGRGRIRRAENYGPRAEVV
Q5QNW6 S39 Sugiyama H2BC18 HIST2H2BF VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q5T7P8 T283 SIGNOR|PSP SYT6 GSSDPYVKIYLLPDRKCKLQtRVHRKTLNPTFDENFHFPVP
Q5T7P8 T417 SIGNOR|PSP SYT6 SDPYVKVSLLCDGRRLKKKKttIKKNTLNPVYNEAIIFDIP
Q5T7P8 T418 SIGNOR|PSP SYT6 DPYVKVSLLCDGRRLKKKKttIKKNTLNPVYNEAIIFDIPP
Q5VTE0 T432 Sugiyama EEF1A1P5 EEF1AL3 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q5XKE5 S155 Sugiyama KRT79 K6L KB38 KRT6L IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q68EM7 S702 SIGNOR ARHGAP17 RICH1 MSTP066 MSTP110 tGQPPGQPSAPSQLSAPRRysssLsPIQAPNHPPPQPPTQA
Q6DN03 S39 Sugiyama H2BC20P HIST2H2BC VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA
Q6DRA6 S39 Sugiyama H2BC19P HIST2H2BD VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA
Q6PCE3 S175 Sugiyama PGM2L1 BM32A PFVPYAVQKLKAVAGVMItAsHNRKEDNGYKVYWETGAQIT
Q6PEY2 T334 Sugiyama TUBA3E ACCMLYRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
Q6PKG0 S627 Sugiyama LARP1 KIAA0731 LARP FLFDEEMEQMDGRKNtFtAWsDEEsDyEIDDRDVNKILIVt
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q6ZMR3 S167 Sugiyama LDHAL6A LDHL2 AWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIHSESCHG
Q6ZN17 S243 PSP LIN28B CSDD2 QEASSTKSSIAPEEQSKKGPsVQKRKKT_____________
Q71U36 T334 Sugiyama TUBA1A TUBA3 ACCLLyRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
Q71UM5 S78 Sugiyama RPS27L GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q7RTS7 S153 Sugiyama KRT74 K6IRS4 KB37 KRT5C KRT6IRS4 IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z2W7 S1040 PSP TRPM8 LTRPC6 TRPP8 YFYMVVKKCFKCCCKEKNMEssVCCFKNEDNETLAWEGVMK
Q7Z2W7 S1041 PSP TRPM8 LTRPC6 TRPP8 FYMVVKKCFKCCCKEKNMEssVCCFKNEDNETLAWEGVMKE
Q7Z417 S652 Sugiyama NUFIP2 KIAA1321 PIG1 NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z794 S177 Sugiyama KRT77 KRT1B IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q86Y46 S145 Sugiyama KRT73 K6IRS3 KB36 KRT6IRS3 IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8IWA4 S284 PSP MFN1 LVEELKVVNALEAQNRIFFVsAKEVLsARKQKAQGMPESGV
Q8IWA4 S290 PSP MFN1 VVNALEAQNRIFFVsAKEVLsARKQKAQGMPESGVALAEGF
Q8IWA4 S86 SIGNOR|PSP MFN1 IIGEVLSRRHMKVAFFGRTSsGKSSVINAMLWDKVLPSGIG
Q8IWX8 S904 Sugiyama CHERP DAN26 SCAF6 KGVGVALDDPyENyRRNKsysFIARMKARDECK________
Q8N257 S39 Sugiyama H2BC26 H2BU1 HIST3H2BB VTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIssKA
Q8NE86 S92 PSP MCU C10orf42 CCDC109A SDDVTVVYQNGLPVISVRLPsRRERCQFTLKPISDSVGVFL
Q8NER1 T705 SIGNOR|PSP TRPV1 VR1 ETVNKIAQESKNIWKLQRAItILDTEKSFLKCMRKAFRSGK
Q8NFA2 S159 SIGNOR NOXO1 P41NOX SH3PXD5 SRVILPTPEEQPLSRAAGRLsIHsLEAQSLRCLQPFCTQDT
Q8TD47 T247 Sugiyama RPS4Y2 RPS4Y2P VIGNGNKPWISLPRGKGIRLtIAEERDKRLAAKQSSG____
Q8WVK2 S132 Sugiyama SNRNP27 FDSTKGKKVDGsVNAyAINVsQKRKYRQYMNRKGGFNRPLD
Q92686 S36 SIGNOR|ELM|iPTMNet|EPSD NRGN ILDIPLDDPGANAAAAKIQAsFRGHMARKKIKSGERGRKGP
Q92793 S437 ELM CREBBP CBP SHWKNCTRHDCPVCLPLKNAsDKRNQQTILGSPASGIQNTI
Q92890 S299 Sugiyama UFD1 UFD1L KKVEEDEAGGRFVAFsGEGQsLRKKGRKP____________
Q93079 S39 Sugiyama H2BC9 H2BFJ HIST1H2BH VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q96C90 T57 SIGNOR PPP1R14B PLCB3N PNG AGEGPGGADDEGPVRRQGKVtVKYDRKELRKRLNLEEWILE
Q96D31 S27 SIGNOR|EPSD|PSP ORAI1 CRACM1 TMEM142A PPPsRssPELPPSGGSTTSGsRRsRRRsGDGEPPGAPPPPP
Q96D31 S30 SIGNOR|EPSD|PSP ORAI1 CRACM1 TMEM142A sRssPELPPSGGSTTSGsRRsRRRsGDGEPPGAPPPPPSAV
Q96G46 T273 Sugiyama DUS3L GAPRQENCGAQQVPAGPGtstPPssPVRtCGPLtDEDVVRL
Q96PX8 S695 SIGNOR SLITRK1 KIAA1910 LRRC12 UNQ233/PRO266 NGPYNADGAHRVYDCGSHSLsD___________________
Q99418 S392 SIGNOR|ELM|EPSD CYTH2 ARNO PSCD2 PSCD2L QAAVSVDPFYEMLAARKKRIsVKKKQEQP____________
Q99848 S270 Sugiyama EBNA1BP2 EBP2 FGGKKKGSKWNtREsyDDVssFRAKTAHGRGLKRPGKKGSN
Q99877 S39 Sugiyama H2BC15 H2BFD HIST1H2BN VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99879 S39 Sugiyama H2BC14 H2BFE HIST1H2BM INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99880 S39 Sugiyama H2BC13 H2BFC HIST1H2BL VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q9BQE3 T334 Sugiyama TUBA1C TUBA6 ACCLLyRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
Q9BRS2 S507 Sugiyama RIOK1 RIO1 ENQVEERtCsDsEDIGssECsDtDSEEQGDHARPKKHTTDP
Q9BRS2 T509 Sugiyama RIOK1 RIO1 QVEERtCsDsEDIGssECsDtDSEEQGDHARPKKHTTDPDI
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9H1D0 S184 SIGNOR|PSP TRPV6 ECAC2 AVVNQNMNLVRALLARRASVsARATGTAFRRSPCNLIYFGE
Q9H1D0 T728 SIGNOR|PSP TRPV6 ECAC2 ELGCPFSPHLSLPMPSVSRStSRssANWERLRQGtLRRDLR
Q9H788 S235 Sugiyama SH2D4A PPP1R38 SH2A EEERTKQICKSWKEDSEWQAsLRKSKAADEKRRSLAKQARE
Q9H7D7 S121 Sugiyama WDR26 CDW2 MIP2 PRO0852 ASSSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLN
Q9HBA0 S162 SIGNOR TRPV4 VRL2 VROAC PPPILKVFNRPILFDIVSRGsTADLDGLLPFLLtHKKRLTD
Q9HBA0 S189 SIGNOR TRPV4 VRL2 VROAC LLPFLLtHKKRLTDEEFREPsTGKTCLPKALLNLSNGRNDT
Q9HBA0 T175 SIGNOR TRPV4 VRL2 VROAC FDIVSRGsTADLDGLLPFLLtHKKRLTDEEFREPsTGKTCL
Q9NPC2 T341 SIGNOR KCNK9 TASK3 KLAPHYFHSISYKIEEISPStLKNSLFPSPISSISPGLHSF
Q9NPQ8 T441 Sugiyama RIC8A AARGLMAGGRPEGQysEDEDtDtDEyKEAKAsINPVTGRVE
Q9NQ39 S157 Sugiyama RPS10P5 RPS10L TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9NQ66 S887 ELM PLCB1 KIAA0581 TTTLTPKPPSQALHSQPAPGsVKAPAKTEDLIQSVLTEVEA
Q9NR19 S30 Sugiyama ACSS2 ACAS2 sGsGSRGQEEAGAGGRARsWsPPPEVsRSAHVPSLQRYREL
Q9NSB2 S178 Sugiyama KRT84 KRTHB4 AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9P2D0 S1200 SIGNOR|EPSD|PSP IBTK BTKI KIAA1417 FtPSKAPKPVNAWASsLHsVsSKsFRDFLLEEKKSVTSHSS
Q9P2D0 S1203 SIGNOR|EPSD|PSP IBTK BTKI KIAA1417 SKAPKPVNAWASsLHsVsSKsFRDFLLEEKKSVTSHSSGDH
Q9UBR2 S78 Sugiyama CTSZ SPADLPKSWDWRNVDGVNyAsItRNQHIPQYCGSCWAHAST
Q9UBS0 S473 GPS6|SIGNOR|ELM|EPSD|PSP RPS6KB2 STK14B PPPPSTTAPLPIRPPSGTKKsKRGRGRPGR___________
Q9UBU3 S41 EPSD|PSP GHRL MTLRP UNQ524/PRO1066 AMAGSSFLSPEHQRVQQRKEsKKPPAKLQPRALAGWLRPED
Q9UEY8 S693 ELM ADD3 ADDL sPEGsPsKsPsKKKKKFRTPsFLKKNKKKEKVEA_______
Q9UH77 S433 SIGNOR|PSP KLHL3 KIAA1129 AYSYKTNEWFFVAPMNTRRSsVGVGVVEGKLYAVGGYDGAS
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UII2 S39 Sugiyama ATP5IF1 ATPI ATPIF1 TMQARGFGsDQSENVDRGAGsIREAGGAFGKREQAEEERyF
Q9UJY1 S14 ELM HSPB8 CRYAC E2IG1 HSP22 PP1629 _______MADGQMPFSCHYPsRLRRDPFRDsPLsSRLLDDG
Q9UJY1 T63 ELM HSPB8 CRYAC E2IG1 HSP22 PP1629 DLTASWPDWALPRLsSAWPGtLRSGMVPRGPTATARFGVPA
Q9UKV3 S388 Sugiyama ACIN1 ACINUS KIAA0670 EEEEREIKssQGLKEKsKsPsPPRLtEDRKKAsLVALPEQt
Q9ULW6 T342 Sugiyama NAP1L2 BPX GTAIEYSTGCEIDWNEGKNVtLKtIKKKQKHRIWGTIRTVT
Q9ULW6 T345 Sugiyama NAP1L2 BPX IEYSTGCEIDWNEGKNVtLKtIKKKQKHRIWGTIRTVTEDF
Q9ULX6 T267 Sugiyama AKAP8L NAKAP NAKAP95 HRIHFB2018 RFGFGFGNGMKQMRRTWKTWtTADFRTKKKKRKQGGsPDEP
Q9UNX3 S9 Sugiyama RPL26L1 RPL26P1 ____________MKFNPFVtsDRsKNRKRHFNAPSHVRRKI
Q9UPR0 T584 Sugiyama PLCL2 KIAA1092 PLCE2 KILIKAKKLsSNCSGVEGDVtDEDEGAEMSQRMGKENMEQP
Q9UQ80 S363 SIGNOR|iPTMNet|EPSD PA2G4 EBP1 yKsEMEVQDAELKALLQssAsRKtQKKKKKKAsKtAENAts
Q9UQ80 T366 SIGNOR|iPTMNet|EPSD PA2G4 EBP1 EMEVQDAELKALLQssAsRKtQKKKKKKAsKtAENAtsGEt
Q9Y2B0 S55 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDELEWEIAQVDPKKTIQMGsFRINPDGsQsVVEVPyARsE
Q9Y5S8 T430 SIGNOR NOX1 MOX1 NOH1 FASILKSIWYKFQCADHNLKtKKIYFYWICRETGAFSWFNN
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 1.480194e-11 10.830 1 0
Cellular Senescence R-HSA-2559583 2.366266e-09 8.626 0 0
Apoptotic execution phase R-HSA-75153 3.036937e-09 8.518 0 0
Axon guidance R-HSA-422475 7.050980e-09 8.152 0 0
Cell Cycle, Mitotic R-HSA-69278 1.017261e-08 7.993 1 0
Cell Cycle Checkpoints R-HSA-69620 2.158370e-08 7.666 0 0
Nervous system development R-HSA-9675108 2.676639e-08 7.572 0 0
Signal Transduction R-HSA-162582 6.344170e-08 7.198 1 0
M Phase R-HSA-68886 8.824223e-08 7.054 1 0
Apoptotic cleavage of cellular proteins R-HSA-111465 9.643610e-08 7.016 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 3.471054e-07 6.460 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.667226e-06 5.574 0 0
mRNA Splicing R-HSA-72172 2.809223e-06 5.551 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.151075e-06 5.502 0 0
Mitotic Anaphase R-HSA-68882 3.317881e-06 5.479 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.764335e-06 5.424 0 0
Mitotic Spindle Checkpoint R-HSA-69618 5.122307e-06 5.291 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 7.434135e-06 5.129 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 8.643911e-06 5.063 0 0
Cellular responses to stimuli R-HSA-8953897 9.015653e-06 5.045 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.017724e-05 4.992 0 0
Cellular responses to stress R-HSA-2262752 1.487332e-05 4.828 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.867474e-05 4.729 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.867474e-05 4.729 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.108551e-05 4.676 1 0
G alpha (12/13) signalling events R-HSA-416482 2.470366e-05 4.607 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.477743e-05 4.606 0 0
NRAGE signals death through JNK R-HSA-193648 2.942083e-05 4.531 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.969507e-05 4.527 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.802049e-05 4.420 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 4.142000e-05 4.383 0 0
Separation of Sister Chromatids R-HSA-2467813 4.989246e-05 4.302 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 5.345798e-05 4.272 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 5.627733e-05 4.250 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 5.916448e-05 4.228 0 0
Mitotic Prometaphase R-HSA-68877 6.838856e-05 4.165 0 0
Chromatin organization R-HSA-4839726 7.287911e-05 4.137 0 0
Apoptosis R-HSA-109581 7.636521e-05 4.117 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 7.804847e-05 4.108 0 0
Chromatin modifying enzymes R-HSA-3247509 9.042477e-05 4.044 0 0
mRNA 3'-end processing R-HSA-72187 9.157656e-05 4.038 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 9.900494e-05 4.004 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.056728e-04 3.976 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.058509e-04 3.975 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.095974e-04 3.960 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.459964e-04 3.836 0 0
Metalloprotease DUBs R-HSA-5689901 1.459964e-04 3.836 0 0
Signaling by ROBO receptors R-HSA-376176 2.018892e-04 3.695 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.055435e-04 3.687 0 0
Mitotic Prophase R-HSA-68875 2.056902e-04 3.687 1 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.296210e-04 3.639 0 0
Interleukin-12 signaling R-HSA-9020591 2.507174e-04 3.601 0 0
Programmed Cell Death R-HSA-5357801 2.737397e-04 3.563 0 0
HATs acetylate histones R-HSA-3214847 2.806595e-04 3.552 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.817721e-04 3.550 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.452235e-04 3.462 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 3.676544e-04 3.435 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.976459e-04 3.401 0 0
G2/M DNA damage checkpoint R-HSA-69473 4.155075e-04 3.381 0 0
Meiosis R-HSA-1500620 4.815955e-04 3.317 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 4.774829e-04 3.321 0 0
Signaling by ALK in cancer R-HSA-9700206 4.774829e-04 3.321 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 5.571502e-04 3.254 0 0
Metabolism of RNA R-HSA-8953854 5.608656e-04 3.251 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 5.775274e-04 3.238 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 6.327476e-04 3.199 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 6.573879e-04 3.182 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 6.405238e-04 3.193 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 6.804465e-04 3.167 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 6.879014e-04 3.162 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 7.339909e-04 3.134 0 0
Oncogene Induced Senescence R-HSA-2559585 7.085051e-04 3.150 0 0
Meiotic synapsis R-HSA-1221632 7.745902e-04 3.111 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 8.133437e-04 3.090 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 7.964162e-04 3.099 0 0
RMTs methylate histone arginines R-HSA-3214858 8.545324e-04 3.068 0 0
Gene expression (Transcription) R-HSA-74160 8.545508e-04 3.068 1 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.157405e-04 3.038 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.157405e-04 3.038 0 0
Signaling by Hippo R-HSA-2028269 9.305152e-04 3.031 0 0
PKMTs methylate histone lysines R-HSA-3214841 9.805056e-04 3.009 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.003029e-03 2.999 0 0
ESR-mediated signaling R-HSA-8939211 1.027075e-03 2.988 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.157833e-03 2.936 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.214829e-03 2.915 0 0
Developmental Biology R-HSA-1266738 1.259229e-03 2.900 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.358509e-03 2.867 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.412017e-03 2.850 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.530003e-03 2.815 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.586869e-03 2.799 1 0
Interleukin-12 family signaling R-HSA-447115 1.594540e-03 2.797 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.671594e-03 2.777 1 0
Reproduction R-HSA-1474165 1.710759e-03 2.767 0 0
Diseases of programmed cell death R-HSA-9645723 1.825751e-03 2.739 0 0
Semaphorin interactions R-HSA-373755 1.858279e-03 2.731 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.876227e-03 2.727 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.968945e-03 2.706 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.086912e-03 2.680 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.245098e-03 2.649 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.190251e-03 2.660 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.266621e-03 2.645 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.424747e-03 2.615 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.525859e-03 2.598 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 2.544017e-03 2.594 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.544017e-03 2.594 0 0
Kinesins R-HSA-983189 2.592768e-03 2.586 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.613368e-03 2.583 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.792834e-03 2.554 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.792834e-03 2.554 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.792834e-03 2.554 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.846975e-03 2.546 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 3.014548e-03 2.521 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 3.014548e-03 2.521 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 3.014548e-03 2.521 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 3.121613e-03 2.506 0 0
Meiotic recombination R-HSA-912446 3.124271e-03 2.505 0 0
DNA methylation R-HSA-5334118 3.191306e-03 2.496 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 3.445090e-03 2.463 0 0
Regulation of TP53 Activity R-HSA-5633007 4.066749e-03 2.391 0 0
RNA Polymerase II Transcription R-HSA-73857 4.053170e-03 2.392 1 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 4.031177e-03 2.395 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 4.016065e-03 2.396 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 4.004818e-03 2.397 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.351705e-03 2.361 0 0
Activation of RAC1 R-HSA-428540 4.533047e-03 2.344 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 4.547109e-03 2.342 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.663686e-03 2.331 0 0
MITF-M-dependent gene expression R-HSA-9856651 4.779708e-03 2.321 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 4.791994e-03 2.319 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 4.791994e-03 2.319 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 5.218083e-03 2.282 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 5.218083e-03 2.282 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 4.897404e-03 2.310 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.867069e-03 2.313 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.867069e-03 2.313 0 0
Netrin-1 signaling R-HSA-373752 5.225446e-03 2.282 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 5.270904e-03 2.278 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 5.290652e-03 2.276 0 0
Signaling by VEGF R-HSA-194138 5.378822e-03 2.269 1 0
Cell junction organization R-HSA-446728 5.474631e-03 2.262 0 0
Cell-Cell communication R-HSA-1500931 5.542825e-03 2.256 0 0
Packaging Of Telomere Ends R-HSA-171306 5.671855e-03 2.246 0 0
HDACs deacetylate histones R-HSA-3214815 5.873525e-03 2.231 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 6.043351e-03 2.219 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 5.985720e-03 2.223 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 5.671855e-03 2.246 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 5.671855e-03 2.246 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.182219e-03 2.209 0 0
L1CAM interactions R-HSA-373760 6.282923e-03 2.202 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 6.363573e-03 2.196 0 0
G2/M Checkpoints R-HSA-69481 6.514939e-03 2.186 0 0
EPH-Ephrin signaling R-HSA-2682334 6.631487e-03 2.178 0 0
Eukaryotic Translation Elongation R-HSA-156842 6.631487e-03 2.178 0 0
Signaling by EGFR R-HSA-177929 6.803672e-03 2.167 0 0
Peptide chain elongation R-HSA-156902 7.105013e-03 2.148 0 0
DNA Double Strand Break Response R-HSA-5693606 7.118136e-03 2.148 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 7.121883e-03 2.147 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 7.329512e-03 2.135 0 0
Heme signaling R-HSA-9707616 7.491698e-03 2.125 0 0
Breakdown of the nuclear lamina R-HSA-352238 7.937659e-03 2.100 0 0
Recycling pathway of L1 R-HSA-437239 8.461368e-03 2.073 0 0
FOXO-mediated transcription R-HSA-9614085 8.535751e-03 2.069 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 8.749097e-03 2.058 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 9.091766e-03 2.041 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 9.091766e-03 2.041 0 0
ISG15 antiviral mechanism R-HSA-1169408 9.770431e-03 2.010 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.005795e-02 1.997 0 0
Defective pyroptosis R-HSA-9710421 1.016403e-02 1.993 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.024258e-02 1.990 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.039480e-02 1.983 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.039480e-02 1.983 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.039574e-02 1.983 0 0
Nuclear import of Rev protein R-HSA-180746 1.049120e-02 1.979 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.049120e-02 1.979 0 0
Specification of primordial germ cells R-HSA-9827857 1.052444e-02 1.978 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.177894e-02 1.929 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.098430e-02 1.959 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.067778e-02 1.972 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.098430e-02 1.959 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.177894e-02 1.929 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.221607e-02 1.913 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.221607e-02 1.913 0 0
TRP channels R-HSA-3295583 1.227500e-02 1.911 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.250271e-02 1.903 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.250271e-02 1.903 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.256615e-02 1.901 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.273462e-02 1.895 0 0
Homology Directed Repair R-HSA-5693538 1.316667e-02 1.881 0 0
Ephrin signaling R-HSA-3928664 1.340868e-02 1.873 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.356891e-02 1.867 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.373339e-02 1.862 0 0
Nucleosome assembly R-HSA-774815 1.373339e-02 1.862 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.427311e-02 1.845 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.429100e-02 1.845 0 0
mTORC1-mediated signalling R-HSA-166208 1.442690e-02 1.841 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.514377e-02 1.820 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 1.514377e-02 1.820 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.654812e-02 1.781 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.588358e-02 1.799 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.515774e-02 1.819 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.492046e-02 1.826 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.657816e-02 1.780 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.683117e-02 1.774 0 0
Rap1 signalling R-HSA-392517 1.683117e-02 1.774 0 0
Adipogenesis R-HSA-9843745 1.698196e-02 1.770 0 0
Adrenoceptors R-HSA-390696 1.707059e-02 1.768 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.721654e-02 1.764 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.767395e-02 1.753 0 0
Death Receptor Signaling R-HSA-73887 1.771924e-02 1.752 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.821956e-02 1.739 0 0
Eukaryotic Translation Termination R-HSA-72764 1.821956e-02 1.739 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.906809e-02 1.720 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.907538e-02 1.720 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.189214e-02 1.660 0 0
Disorders of Nervous System Development R-HSA-9697154 2.189214e-02 1.660 0 0
Pervasive developmental disorders R-HSA-9005895 2.189214e-02 1.660 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.084122e-02 1.681 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.084122e-02 1.681 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.084122e-02 1.681 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.084122e-02 1.681 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.127113e-02 1.672 0 0
Metabolism of non-coding RNA R-HSA-194441 2.068340e-02 1.684 0 0
snRNP Assembly R-HSA-191859 2.068340e-02 1.684 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.160382e-02 1.665 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 2.024978e-02 1.694 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.939991e-02 1.712 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 2.189214e-02 1.660 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.135965e-02 1.670 0 0
Neurodegenerative Diseases R-HSA-8863678 2.135965e-02 1.670 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.078869e-02 1.682 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.005609e-02 1.698 0 0
Gene Silencing by RNA R-HSA-211000 2.024978e-02 1.694 0 0
Adherens junctions interactions R-HSA-418990 2.196087e-02 1.658 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.206804e-02 1.656 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.323006e-02 1.634 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.338448e-02 1.631 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 2.338448e-02 1.631 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.338448e-02 1.631 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.371241e-02 1.625 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 2.399273e-02 1.620 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.406448e-02 1.619 0 0
Disorders of Developmental Biology R-HSA-9675151 2.442828e-02 1.612 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.442828e-02 1.612 0 0
Interleukin-37 signaling R-HSA-9008059 2.512960e-02 1.600 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.538534e-02 1.595 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.986386e-02 1.525 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.986386e-02 1.525 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.986386e-02 1.525 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.986386e-02 1.525 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.986386e-02 1.525 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.986386e-02 1.525 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.986386e-02 1.525 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.986386e-02 1.525 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.986386e-02 1.525 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 3.025700e-02 1.519 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 2.824903e-02 1.549 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 2.824903e-02 1.549 0 0
EGFR downregulation R-HSA-182971 2.946627e-02 1.531 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.820047e-02 1.550 0 0
Circadian clock R-HSA-9909396 2.941627e-02 1.531 0 0
Chromosome Maintenance R-HSA-73886 2.794864e-02 1.554 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.820047e-02 1.550 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.080583e-02 1.511 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.675899e-02 1.573 0 0
Selenocysteine synthesis R-HSA-2408557 3.118687e-02 1.506 0 0
Influenza Infection R-HSA-168255 2.904227e-02 1.537 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 3.126059e-02 1.505 0 0
Regulation of CDH11 function R-HSA-9762292 3.182485e-02 1.497 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 3.250138e-02 1.488 0 0
Signaling by TGFBR3 R-HSA-9839373 3.260763e-02 1.487 0 0
Cell-cell junction organization R-HSA-421270 3.289266e-02 1.483 0 0
Generic Transcription Pathway R-HSA-212436 3.317987e-02 1.479 1 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.319067e-02 1.479 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 3.381909e-02 1.471 0 0
Interaction between L1 and Ankyrins R-HSA-445095 3.581446e-02 1.446 0 0
Viral mRNA Translation R-HSA-192823 3.677678e-02 1.434 0 0
Post NMDA receptor activation events R-HSA-438064 3.730984e-02 1.428 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 3.734182e-02 1.428 0 0
Cleavage of the damaged purine R-HSA-110331 3.734182e-02 1.428 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 3.966808e-02 1.402 0 0
Depyrimidination R-HSA-73928 3.966808e-02 1.402 0 0
Integrin signaling R-HSA-354192 3.967767e-02 1.401 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 3.967767e-02 1.401 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.967767e-02 1.401 0 0
Deubiquitination R-HSA-5688426 4.036912e-02 1.394 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 4.045662e-02 1.393 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 4.148296e-02 1.382 0 0
Pyroptosis R-HSA-5620971 4.184165e-02 1.378 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 4.261298e-02 1.370 0 0
Depurination R-HSA-73927 4.261298e-02 1.370 0 0
Cellular response to heat stress R-HSA-3371556 4.429530e-02 1.354 0 0
Cell-extracellular matrix interactions R-HSA-446353 4.434195e-02 1.353 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 4.434195e-02 1.353 0 0
Germ layer formation at gastrulation R-HSA-9754189 4.466739e-02 1.350 0 0
Regulation of gap junction activity R-HSA-191650 4.749406e-02 1.323 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.749406e-02 1.323 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 5.273149e-02 1.278 0 0
Signaling by GSK3beta mutants R-HSA-5339716 5.273149e-02 1.278 0 0
Phosphorylation of the APC/C R-HSA-176412 5.416535e-02 1.266 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 5.416535e-02 1.266 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 5.326431e-02 1.274 0 0
Striated Muscle Contraction R-HSA-390522 4.559829e-02 1.341 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 5.208826e-02 1.283 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 5.208826e-02 1.283 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 5.208826e-02 1.283 0 0
Signal amplification R-HSA-392518 5.208826e-02 1.283 0 0
Mitochondrial biogenesis R-HSA-1592230 5.196622e-02 1.284 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 4.749406e-02 1.323 0 0
Organelle biogenesis and maintenance R-HSA-1852241 5.136323e-02 1.289 0 0
DNA Repair R-HSA-73894 5.059751e-02 1.296 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 4.851667e-02 1.314 0 0
Formation of definitive endoderm R-HSA-9823730 5.326431e-02 1.274 0 0
EPHB-mediated forward signaling R-HSA-3928662 5.038095e-02 1.298 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.837512e-02 1.315 0 0
Regulation of endogenous retroelements R-HSA-9842860 5.489974e-02 1.260 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 5.859964e-02 1.232 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 5.916336e-02 1.228 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 5.953497e-02 1.225 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 5.953497e-02 1.225 0 0
HDMs demethylate histones R-HSA-3214842 5.953497e-02 1.225 0 0
TGFBR3 expression R-HSA-9839394 5.953497e-02 1.225 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 5.953497e-02 1.225 0 0
Long-term potentiation R-HSA-9620244 5.953497e-02 1.225 0 0
Telomere Maintenance R-HSA-157579 6.015361e-02 1.221 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 6.143141e-02 1.212 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 6.143141e-02 1.212 0 0
Oligomerization of connexins into connexons R-HSA-190704 6.163355e-02 1.210 0 0
Transport of glycerol from adipocytes to the liver by Aquaporins R-HSA-432030 6.163355e-02 1.210 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 6.163355e-02 1.210 0 0
Transport of connexins along the secretory pathway R-HSA-190827 6.163355e-02 1.210 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 6.291109e-02 1.201 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 6.291109e-02 1.201 0 0
Signaling downstream of RAS mutants R-HSA-9649948 6.291109e-02 1.201 0 0
Signaling by RAS mutants R-HSA-6802949 6.291109e-02 1.201 0 0
Diseases of DNA repair R-HSA-9675135 6.291109e-02 1.201 0 0
UCH proteinases R-HSA-5689603 6.349858e-02 1.197 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 6.378475e-02 1.195 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 6.520512e-02 1.186 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 6.520512e-02 1.186 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 6.558525e-02 1.183 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 6.558525e-02 1.183 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 6.558525e-02 1.183 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 6.558525e-02 1.183 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 6.558525e-02 1.183 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 6.558525e-02 1.183 0 0
Regulation of TP53 Degradation R-HSA-6804757 6.683610e-02 1.175 0 0
Activation of HOX genes during differentiation R-HSA-5619507 6.815933e-02 1.166 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 6.815933e-02 1.166 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 6.856071e-02 1.164 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 6.856071e-02 1.164 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 6.874901e-02 1.163 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 7.894023e-02 1.103 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.894023e-02 1.103 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 7.746504e-02 1.111 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 7.337500e-02 1.134 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 7.337500e-02 1.134 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 8.490147e-02 1.071 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 7.260732e-02 1.139 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 8.202944e-02 1.086 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 8.202944e-02 1.086 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 7.511555e-02 1.124 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 7.583785e-02 1.120 0 0
Nuclear Receptor transcription pathway R-HSA-383280 7.481766e-02 1.126 0 0
HCMV Early Events R-HSA-9609690 7.527937e-02 1.123 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.894023e-02 1.103 0 0
Gap junction trafficking and regulation R-HSA-157858 8.528034e-02 1.069 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 8.400722e-02 1.076 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 7.511555e-02 1.124 0 0
Cellular response to starvation R-HSA-9711097 7.731503e-02 1.112 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 8.003058e-02 1.097 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 8.202944e-02 1.086 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 8.227821e-02 1.085 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 7.872767e-02 1.104 1 0
Calcineurin activates NFAT R-HSA-2025928 7.894023e-02 1.103 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 7.746504e-02 1.111 0 0
Regulation of PTEN gene transcription R-HSA-8943724 7.725105e-02 1.112 0 0
TCF dependent signaling in response to WNT R-HSA-201681 7.612162e-02 1.118 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 7.733879e-02 1.112 0 0
G-protein mediated events R-HSA-112040 8.344149e-02 1.079 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 8.779034e-02 1.057 0 0
GPER1 signaling R-HSA-9634597 7.733879e-02 1.112 0 0
SARS-CoV-1-host interactions R-HSA-9692914 7.813335e-02 1.107 0 0
Muscle contraction R-HSA-397014 8.958189e-02 1.048 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 9.093339e-02 1.041 0 0
Synaptic adhesion-like molecules R-HSA-8849932 9.093339e-02 1.041 0 0
Transport of connexons to the plasma membrane R-HSA-190872 9.093339e-02 1.041 0 0
Apoptotic factor-mediated response R-HSA-111471 9.093339e-02 1.041 0 0
S Phase R-HSA-69242 9.151065e-02 1.039 0 0
Signaling by NTRKs R-HSA-166520 9.151065e-02 1.039 0 0
Resolution of D-Loop Structures R-HSA-5693537 9.215398e-02 1.035 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.215398e-02 1.035 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 9.299313e-02 1.032 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 9.310630e-02 1.031 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.249354e-01 0.903 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.249354e-01 0.903 0 0
KIT mutants bind TKIs R-HSA-9669921 1.249354e-01 0.903 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.249354e-01 0.903 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.249354e-01 0.903 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.249354e-01 0.903 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.249354e-01 0.903 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.249354e-01 0.903 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.249354e-01 0.903 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.249354e-01 0.903 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.249354e-01 0.903 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.249354e-01 0.903 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.249354e-01 0.903 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.249354e-01 0.903 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.249354e-01 0.903 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.249354e-01 0.903 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.249354e-01 0.903 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.249354e-01 0.903 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.249354e-01 0.903 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.249354e-01 0.903 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.249354e-01 0.903 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.006080e-01 0.997 0 0
Regulation of TP53 Expression R-HSA-6804754 1.006080e-01 0.997 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.006080e-01 0.997 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.006080e-01 0.997 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.006080e-01 0.997 0 0
Diseases of cellular response to stress R-HSA-9675132 1.006080e-01 0.997 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.006080e-01 0.997 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.006080e-01 0.997 0 0
Potassium transport channels R-HSA-1296067 1.006080e-01 0.997 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.006080e-01 0.997 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.006080e-01 0.997 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.006080e-01 0.997 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.006080e-01 0.997 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.006080e-01 0.997 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.006080e-01 0.997 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.006080e-01 0.997 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.006080e-01 0.997 0 0
CREB phosphorylation R-HSA-199920 1.206988e-01 0.918 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 9.839985e-02 1.007 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 9.839985e-02 1.007 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 9.839985e-02 1.007 0 0
Signaling by APC mutants R-HSA-4839744 1.198532e-01 0.921 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.198532e-01 0.921 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.198532e-01 0.921 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.198532e-01 0.921 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 9.602756e-02 1.018 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 9.602756e-02 1.018 0 0
DCC mediated attractive signaling R-HSA-418885 1.135127e-01 0.945 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.135127e-01 0.945 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.135127e-01 0.945 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.055837e-01 0.976 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 9.740080e-02 1.011 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 1.108553e-01 0.955 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.108553e-01 0.955 0 0
Deadenylation of mRNA R-HSA-429947 1.108553e-01 0.955 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.108553e-01 0.955 0 0
RAF activation R-HSA-5673000 1.029776e-01 0.987 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.058740e-01 0.975 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.210578e-01 0.917 0 0
Specification of the neural plate border R-HSA-9834899 1.055837e-01 0.976 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.034325e-01 0.985 0 0
Ribosome-associated quality control R-HSA-9948299 1.027779e-01 0.988 0 0
Receptor Mediated Mitophagy R-HSA-8934903 9.839985e-02 1.007 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.142696e-01 0.942 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.248884e-01 0.903 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.014018e-01 0.994 0 0
Selective autophagy R-HSA-9663891 1.058740e-01 0.975 0 0
DNA Replication R-HSA-69306 1.182352e-01 0.927 0 0
Neurexins and neuroligins R-HSA-6794361 1.120403e-01 0.951 0 0
Ub-specific processing proteases R-HSA-5689880 1.232408e-01 0.909 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.244992e-01 0.905 0 0
Lipid particle organization R-HSA-8964572 1.206988e-01 0.918 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.001290e-01 0.999 0 0
RAF/MAP kinase cascade R-HSA-5673001 9.950341e-02 1.002 0 0
The NLRP3 inflammasome R-HSA-844456 1.055837e-01 0.976 0 0
MAPK family signaling cascades R-HSA-5683057 1.109046e-01 0.955 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.034325e-01 0.985 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.986399e-02 1.001 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 1.114973e-01 0.953 0 0
Glycolysis R-HSA-70171 1.138674e-01 0.944 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.134609e-01 0.945 0 0
MAP2K and MAPK activation R-HSA-5674135 1.256797e-01 0.901 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.256797e-01 0.901 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.261274e-01 0.899 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 1.281854e-01 0.892 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.285156e-01 0.891 0 0
Signaling by Interleukins R-HSA-449147 1.298611e-01 0.887 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.315692e-01 0.881 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.319206e-01 0.880 0 0
Translation initiation complex formation R-HSA-72649 1.323015e-01 0.878 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.323015e-01 0.878 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.347802e-01 0.870 0 0
NGF-stimulated transcription R-HSA-9031628 1.351136e-01 0.869 0 0
MTOR signalling R-HSA-165159 1.375887e-01 0.861 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.382580e-01 0.859 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.393605e-01 0.856 0 0
Voltage gated Potassium channels R-HSA-1296072 1.395387e-01 0.855 0 0
Myogenesis R-HSA-525793 1.405147e-01 0.852 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 1.431176e-01 0.844 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 1.431176e-01 0.844 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.431176e-01 0.844 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.431176e-01 0.844 0 0
Signaling by AXIN mutants R-HSA-4839735 1.431176e-01 0.844 0 0
Axonal growth stimulation R-HSA-209563 1.444926e-01 0.840 0 0
MET activates PTPN11 R-HSA-8865999 1.444926e-01 0.840 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.444926e-01 0.840 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 1.444926e-01 0.840 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 1.444926e-01 0.840 0 0
tRNA processing in the nucleus R-HSA-6784531 1.500198e-01 0.824 0 0
TBC/RABGAPs R-HSA-8854214 1.500677e-01 0.824 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.508644e-01 0.821 0 0
Netrin mediated repulsion signals R-HSA-418886 1.508644e-01 0.821 0 0
Ca2+ activated K+ channels R-HSA-1296052 1.508644e-01 0.821 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.508644e-01 0.821 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 1.508644e-01 0.821 0 0
Regulation of PTEN localization R-HSA-8948747 1.508644e-01 0.821 0 0
Centrosome maturation R-HSA-380287 1.510278e-01 0.821 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 1.525949e-01 0.816 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.525949e-01 0.816 0 0
rRNA processing R-HSA-72312 1.537969e-01 0.813 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.544348e-01 0.811 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.553603e-01 0.809 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.561664e-01 0.806 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.561664e-01 0.806 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.562652e-01 0.806 1 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.577428e-01 0.802 1 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.342682e-01 0.630 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.342682e-01 0.630 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.342682e-01 0.630 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.342682e-01 0.630 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 2.342682e-01 0.630 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.342682e-01 0.630 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.342682e-01 0.630 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 2.342682e-01 0.630 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.342682e-01 0.630 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.914535e-01 0.718 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 1.914535e-01 0.718 0 0
NADE modulates death signalling R-HSA-205025 1.914535e-01 0.718 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.914535e-01 0.718 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.914535e-01 0.718 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 1.914535e-01 0.718 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 1.914535e-01 0.718 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.914535e-01 0.718 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 2.400378e-01 0.620 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 2.400378e-01 0.620 0 0
IRS activation R-HSA-74713 2.400378e-01 0.620 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.400378e-01 0.620 0 0
G2 Phase R-HSA-68911 2.400378e-01 0.620 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.400378e-01 0.620 0 0
Type I hemidesmosome assembly R-HSA-446107 1.831161e-01 0.737 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.831161e-01 0.737 0 0
FGFR1b ligand binding and activation R-HSA-190370 1.831161e-01 0.737 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.679878e-01 0.775 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.679878e-01 0.775 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 2.169755e-01 0.664 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 2.169755e-01 0.664 0 0
Gap junction degradation R-HSA-190873 2.169755e-01 0.664 0 0
ALK mutants bind TKIs R-HSA-9700645 2.169755e-01 0.664 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.942440e-01 0.712 0 0
Regulation of KIT signaling R-HSA-1433559 2.216589e-01 0.654 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.216589e-01 0.654 0 0
Notch-HLH transcription pathway R-HSA-350054 1.750286e-01 0.757 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.735722e-01 0.761 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.912489e-01 0.718 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.152874e-01 0.667 0 0
Activation of the pre-replicative complex R-HSA-68962 2.096126e-01 0.679 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 2.096126e-01 0.679 0 0
Downstream signal transduction R-HSA-186763 2.285992e-01 0.641 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 2.285992e-01 0.641 0 0
Trafficking of AMPA receptors R-HSA-399719 2.285992e-01 0.641 1 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.610139e-01 0.793 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.610139e-01 0.793 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.979545e-01 0.703 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.290826e-01 0.640 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.666620e-01 0.778 0 0
G alpha (z) signalling events R-HSA-418597 2.261797e-01 0.646 1 1
PKR-mediated signaling R-HSA-9833482 2.047779e-01 0.689 0 0
Mitophagy R-HSA-5205647 1.867823e-01 0.729 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 1.818321e-01 0.740 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 1.818321e-01 0.740 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.947644e-01 0.710 0 0
Signaling by ERBB2 R-HSA-1227986 2.039093e-01 0.691 0 0
DNA Damage Bypass R-HSA-73893 2.356586e-01 0.628 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.679878e-01 0.775 0 0
Activation of GABAB receptors R-HSA-991365 2.290826e-01 0.640 0 0
Gap junction trafficking R-HSA-190828 1.630979e-01 0.788 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.610139e-01 0.793 0 0
MHC class II antigen presentation R-HSA-2132295 2.198576e-01 0.658 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 2.365063e-01 0.626 1 1
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.783459e-01 0.749 0 0
Cyclin D associated events in G1 R-HSA-69231 1.630979e-01 0.788 0 0
G1 Phase R-HSA-69236 1.630979e-01 0.788 0 0
GAB1 signalosome R-HSA-180292 1.964204e-01 0.707 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.356586e-01 0.628 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.356586e-01 0.628 0 0
Gap junction assembly R-HSA-190861 1.867823e-01 0.729 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 1.914535e-01 0.718 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 1.739761e-01 0.760 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.088559e-01 0.680 0 0
RNA Polymerase I Transcription R-HSA-73864 1.822999e-01 0.739 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.169755e-01 0.664 0 0
GABA B receptor activation R-HSA-977444 2.290826e-01 0.640 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.400378e-01 0.620 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.679878e-01 0.775 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.047779e-01 0.689 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.722928e-01 0.764 0 0
Activation of BH3-only proteins R-HSA-114452 2.096126e-01 0.679 0 0
Macroautophagy R-HSA-1632852 1.660036e-01 0.780 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.128403e-01 0.672 0 0
HIV Life Cycle R-HSA-162587 1.915707e-01 0.718 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.611120e-01 0.793 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.400378e-01 0.620 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 2.216589e-01 0.654 0 0
Effects of PIP2 hydrolysis R-HSA-114508 1.707436e-01 0.768 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.867823e-01 0.729 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 1.942440e-01 0.712 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.777300e-01 0.750 0 0
Opioid Signalling R-HSA-111885 2.051536e-01 0.688 0 0
Signaling by LTK R-HSA-9842663 1.679878e-01 0.775 0 0
Polo-like kinase mediated events R-HSA-156711 1.964204e-01 0.707 0 0
Neuronal System R-HSA-112316 1.803408e-01 0.744 1 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.970775e-01 0.705 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.603041e-01 0.795 0 0
G2/M Transition R-HSA-69275 2.092833e-01 0.679 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.290826e-01 0.640 0 0
Co-stimulation by CD28 R-HSA-389356 2.202523e-01 0.657 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.116760e-01 0.674 0 0
Host Interactions of HIV factors R-HSA-162909 1.683461e-01 0.774 0 0
Amyloid fiber formation R-HSA-977225 2.164707e-01 0.665 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.342682e-01 0.630 0 0
Inhibition of PKR R-HSA-169131 2.342682e-01 0.630 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.914535e-01 0.718 0 0
MTF1 activates gene expression R-HSA-5660489 1.914535e-01 0.718 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.400378e-01 0.620 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 1.831161e-01 0.737 0 0
Unwinding of DNA R-HSA-176974 2.169755e-01 0.664 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 2.169755e-01 0.664 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 1.942440e-01 0.712 0 0
Inflammasomes R-HSA-622312 1.735722e-01 0.761 0 0
Cytoprotection by HMOX1 R-HSA-9707564 1.656069e-01 0.781 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.703061e-01 0.769 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 2.331286e-01 0.632 0 0
Calmodulin induced events R-HSA-111933 2.206483e-01 0.656 0 0
CaM pathway R-HSA-111997 2.206483e-01 0.656 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.152874e-01 0.667 0 0
Base Excision Repair R-HSA-73884 1.794576e-01 0.746 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.167512e-01 0.664 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.831161e-01 0.737 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.942440e-01 0.712 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 2.400378e-01 0.620 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.964204e-01 0.707 1 1
Inositol phosphate metabolism R-HSA-1483249 2.272322e-01 0.644 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.217058e-01 0.654 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.647856e-01 0.783 0 0
OAS antiviral response R-HSA-8983711 1.679878e-01 0.775 0 0
NrCAM interactions R-HSA-447038 2.400378e-01 0.620 0 0
Co-inhibition by BTLA R-HSA-9927353 2.400378e-01 0.620 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.021327e-01 0.694 0 0
Signal regulatory protein family interactions R-HSA-391160 2.216589e-01 0.654 0 0
Cilium Assembly R-HSA-5617833 2.406530e-01 0.619 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.408088e-01 0.618 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 2.408587e-01 0.618 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.439620e-01 0.613 0 0
Negative regulation of MET activity R-HSA-6807004 2.439620e-01 0.613 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 2.439620e-01 0.613 0 0
Signaling by FGFR4 R-HSA-5654743 2.457644e-01 0.609 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.481205e-01 0.605 0 0
DNA strand elongation R-HSA-69190 2.481415e-01 0.605 0 0
Cardiac conduction R-HSA-5576891 2.497670e-01 0.602 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 2.500043e-01 0.602 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.500043e-01 0.602 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.500043e-01 0.602 0 0
Formation of the anterior neural plate R-HSA-9823739 2.500043e-01 0.602 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 2.501398e-01 0.602 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 2.519867e-01 0.599 0 0
Folding of actin by CCT/TriC R-HSA-390450 2.519867e-01 0.599 0 0
Signal attenuation R-HSA-74749 2.519867e-01 0.599 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.519867e-01 0.599 0 0
Pexophagy R-HSA-9664873 2.519867e-01 0.599 0 0
Signaling by Leptin R-HSA-2586552 2.519867e-01 0.599 0 0
Signaling by NOTCH R-HSA-157118 2.524667e-01 0.598 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.531972e-01 0.597 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.549321e-01 0.594 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.573958e-01 0.589 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 2.583271e-01 0.588 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.583271e-01 0.588 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 3.299463e-01 0.482 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 3.299463e-01 0.482 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 3.299463e-01 0.482 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.299463e-01 0.482 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.299463e-01 0.482 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.299463e-01 0.482 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 3.299463e-01 0.482 0 0
Mitochondrial transcription initiation R-HSA-163282 3.299463e-01 0.482 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 3.299463e-01 0.482 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.299463e-01 0.482 0 0
XAV939 stabilizes AXIN R-HSA-5545619 3.299463e-01 0.482 0 0
MPS IIID - Sanfilippo syndrome D R-HSA-2206305 3.299463e-01 0.482 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 3.299463e-01 0.482 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 3.299463e-01 0.482 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 3.299463e-01 0.482 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.299463e-01 0.482 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 3.299463e-01 0.482 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 3.299463e-01 0.482 0 0
Intestinal infectious diseases R-HSA-8942233 3.299463e-01 0.482 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.299463e-01 0.482 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.299463e-01 0.482 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 2.891076e-01 0.539 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.891076e-01 0.539 0 0
Phosphorylation of Emi1 R-HSA-176417 2.891076e-01 0.539 0 0
Defective PAPSS2 causes SEMD-PA R-HSA-3560796 4.136743e-01 0.383 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.136743e-01 0.383 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.136743e-01 0.383 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.136743e-01 0.383 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.136743e-01 0.383 0 0
Defective DHDDS causes RP59 R-HSA-4755609 4.136743e-01 0.383 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.377835e-01 0.471 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 3.377835e-01 0.471 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.377835e-01 0.471 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.877268e-01 0.541 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 2.877268e-01 0.541 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 2.877268e-01 0.541 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.790552e-01 0.554 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 3.238112e-01 0.490 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 3.238112e-01 0.490 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 3.238112e-01 0.490 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.853984e-01 0.414 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.853984e-01 0.414 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 3.853984e-01 0.414 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.853984e-01 0.414 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 3.853984e-01 0.414 0 0
SOS-mediated signalling R-HSA-112412 3.853984e-01 0.414 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 3.853984e-01 0.414 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.853984e-01 0.414 0 0
The NLRP1 inflammasome R-HSA-844455 4.869442e-01 0.313 0 0
MET interacts with TNS proteins R-HSA-8875513 4.869442e-01 0.313 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 4.869442e-01 0.313 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 4.869442e-01 0.313 0 0
Classical Kir channels R-HSA-1296053 4.869442e-01 0.313 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.869442e-01 0.313 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.869442e-01 0.313 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 4.869442e-01 0.313 0 0
p75NTR recruits signalling complexes R-HSA-209543 3.598971e-01 0.444 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 3.598971e-01 0.444 0 0
Polymerase switching R-HSA-69091 3.598971e-01 0.444 0 0
Leading Strand Synthesis R-HSA-69109 3.598971e-01 0.444 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.806538e-01 0.552 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.384172e-01 0.471 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.384172e-01 0.471 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 4.314576e-01 0.365 0 0
RSK activation R-HSA-444257 4.314576e-01 0.365 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 4.314576e-01 0.365 0 0
Formation of annular gap junctions R-HSA-196025 4.314576e-01 0.365 0 0
Activation of RAS in B cells R-HSA-1169092 4.314576e-01 0.365 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 4.314576e-01 0.365 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 4.314576e-01 0.365 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 4.314576e-01 0.365 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.681699e-01 0.572 1 0
Phase 0 - rapid depolarisation R-HSA-5576892 3.033901e-01 0.518 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.956843e-01 0.403 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 3.956843e-01 0.403 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 3.956843e-01 0.403 0 0
Adenylate cyclase activating pathway R-HSA-170660 3.956843e-01 0.403 0 0
Formation of axial mesoderm R-HSA-9796292 3.956843e-01 0.403 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.956843e-01 0.403 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.886134e-01 0.540 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.683299e-01 0.434 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 3.683299e-01 0.434 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.264403e-01 0.486 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 3.094004e-01 0.509 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.980204e-01 0.526 0 0
Thromboxane signalling through TP receptor R-HSA-428930 3.718673e-01 0.430 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 3.718673e-01 0.430 0 0
E2F mediated regulation of DNA replication R-HSA-113510 3.981553e-01 0.400 0 0
Removal of the Flap Intermediate R-HSA-69166 4.309145e-01 0.366 0 0
cGMP effects R-HSA-418457 4.309145e-01 0.366 0 0
Regulated proteolysis of p75NTR R-HSA-193692 4.756067e-01 0.323 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 4.277324e-01 0.369 0 0
Co-inhibition by CTLA4 R-HSA-389513 4.277324e-01 0.369 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 4.653700e-01 0.332 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 4.653700e-01 0.332 0 0
Regulation of RAS by GAPs R-HSA-5658442 3.711880e-01 0.430 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 4.569165e-01 0.340 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 4.569165e-01 0.340 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 4.569165e-01 0.340 0 0
Binding and entry of HIV virion R-HSA-173107 5.176039e-01 0.286 0 0
MAPK3 (ERK1) activation R-HSA-110056 5.176039e-01 0.286 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 5.176039e-01 0.286 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 5.176039e-01 0.286 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.496551e-01 0.347 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.496551e-01 0.347 0 0
PPARA activates gene expression R-HSA-1989781 2.979933e-01 0.526 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 4.084599e-01 0.389 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 4.988708e-01 0.302 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 4.988708e-01 0.302 0 0
Phase 4 - resting membrane potential R-HSA-5576886 4.988708e-01 0.302 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.320734e-01 0.364 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 4.855799e-01 0.314 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 4.855799e-01 0.314 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 4.271155e-01 0.369 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 4.750904e-01 0.323 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 4.663088e-01 0.331 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 4.518878e-01 0.345 0 0
Late endosomal microautophagy R-HSA-9615710 5.001281e-01 0.301 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 4.826759e-01 0.316 0 0
Neutrophil degranulation R-HSA-6798695 4.066394e-01 0.391 0 0
Signaling by FGFR2 R-HSA-5654738 5.090608e-01 0.293 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 5.001281e-01 0.301 0 0
Chaperonin-mediated protein folding R-HSA-390466 5.163027e-01 0.287 0 0
IGF1R signaling cascade R-HSA-2428924 3.680157e-01 0.434 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 2.681699e-01 0.572 0 0
Signaling by FGFR3 R-HSA-5654741 2.802771e-01 0.552 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.198309e-01 0.495 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 4.847135e-01 0.315 0 0
Regulation of mitotic cell cycle R-HSA-453276 4.847135e-01 0.315 0 0
Signaling by PDGFR in disease R-HSA-9671555 4.855799e-01 0.314 0 0
Lagging Strand Synthesis R-HSA-69186 4.569165e-01 0.340 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.277324e-01 0.369 0 0
Early Phase of HIV Life Cycle R-HSA-162594 4.569165e-01 0.340 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 3.238112e-01 0.490 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 3.085948e-01 0.511 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 3.328822e-01 0.478 0 0
p75NTR regulates axonogenesis R-HSA-193697 4.756067e-01 0.323 0 0
Signaling by FGFR1 R-HSA-5654736 3.522402e-01 0.453 0 0
NRIF signals cell death from the nucleus R-HSA-205043 4.309145e-01 0.366 0 0
Processive synthesis on the lagging strand R-HSA-69183 4.653700e-01 0.332 0 0
p75NTR signals via NF-kB R-HSA-193639 4.653700e-01 0.332 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 4.239081e-01 0.373 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 3.846569e-01 0.415 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 4.314576e-01 0.365 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 4.797717e-01 0.319 0 0
Formation of lateral plate mesoderm R-HSA-9758920 2.891076e-01 0.539 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.853984e-01 0.414 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.853984e-01 0.414 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.886134e-01 0.540 0 0
Signalling to RAS R-HSA-167044 4.569165e-01 0.340 0 0
PI3K/AKT activation R-HSA-198203 5.176039e-01 0.286 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.094004e-01 0.509 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 4.911094e-01 0.309 0 0
PTEN Regulation R-HSA-6807070 2.696033e-01 0.569 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 4.139327e-01 0.383 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 3.683299e-01 0.434 0 0
HSF1-dependent transactivation R-HSA-3371571 2.675873e-01 0.573 0 0
GABA receptor activation R-HSA-977443 3.026867e-01 0.519 0 0
Telomere C-strand synthesis initiation R-HSA-174430 4.653700e-01 0.332 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 4.569165e-01 0.340 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.416567e-01 0.466 0 0
Nuclear RNA decay R-HSA-9930044 4.199486e-01 0.377 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.693250e-01 0.433 0 0
Hedgehog 'off' state R-HSA-5610787 5.154033e-01 0.288 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 4.224708e-01 0.374 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 4.224708e-01 0.374 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 4.224708e-01 0.374 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 4.224708e-01 0.374 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 4.988708e-01 0.302 0 0
Autophagy R-HSA-9612973 3.079128e-01 0.512 0 0
Regulation of CDH1 Function R-HSA-9764561 5.009355e-01 0.300 0 0
GPVI-mediated activation cascade R-HSA-114604 3.517191e-01 0.454 0 0
HCMV Infection R-HSA-9609646 2.741024e-01 0.562 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 4.906734e-01 0.309 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.891076e-01 0.539 0 0
Transcription from mitochondrial promoters R-HSA-75944 4.136743e-01 0.383 0 0
Activation of SMO R-HSA-5635838 2.790552e-01 0.554 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 3.238112e-01 0.490 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.314576e-01 0.365 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 4.314576e-01 0.365 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 4.314576e-01 0.365 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 3.033901e-01 0.518 0 0
FGFR1c ligand binding and activation R-HSA-190373 3.956843e-01 0.403 0 0
Aggrephagy R-HSA-9646399 2.941314e-01 0.531 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 3.979442e-01 0.400 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 5.176039e-01 0.286 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 4.496551e-01 0.347 0 0
HIV Infection R-HSA-162906 3.199098e-01 0.495 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 4.733921e-01 0.325 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 4.239081e-01 0.373 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 2.886134e-01 0.540 0 0
Signal transduction by L1 R-HSA-445144 4.277324e-01 0.369 0 0
Interleukin-2 signaling R-HSA-9020558 2.877268e-01 0.541 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.761058e-01 0.559 0 0
Signaling by WNT in cancer R-HSA-4791275 3.965503e-01 0.402 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 4.988708e-01 0.302 0 0
Membrane Trafficking R-HSA-199991 2.824778e-01 0.549 0 0
Signaling by NOTCH1 R-HSA-1980143 3.342666e-01 0.476 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.597124e-01 0.586 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 4.891286e-01 0.311 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 4.861823e-01 0.313 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.891076e-01 0.539 0 0
p38MAPK events R-HSA-171007 4.653700e-01 0.332 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 5.136117e-01 0.289 0 0
Switching of origins to a post-replicative state R-HSA-69052 5.174583e-01 0.286 0 0
Transmission across Chemical Synapses R-HSA-112315 3.897460e-01 0.409 1 0
Cardiogenesis R-HSA-9733709 2.681699e-01 0.572 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.806776e-01 0.552 0 0
Ion homeostasis R-HSA-5578775 3.522402e-01 0.453 0 0
Regulated Necrosis R-HSA-5218859 3.193022e-01 0.496 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 4.454126e-01 0.351 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.913853e-01 0.536 0 0
Signaling by WNT R-HSA-195721 4.251469e-01 0.371 1 0
Activation of ATR in response to replication stress R-HSA-176187 2.681699e-01 0.572 0 0
mRNA Editing R-HSA-75072 4.756067e-01 0.323 0 0
Potassium Channels R-HSA-1296071 2.682235e-01 0.572 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 3.680157e-01 0.434 0 0
Cellular response to chemical stress R-HSA-9711123 4.212306e-01 0.375 0 0
Signalling to ERKs R-HSA-187687 3.304592e-01 0.481 0 0
Interferon Signaling R-HSA-913531 4.054221e-01 0.392 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.299463e-01 0.482 0 0
mRNA Editing: A to I Conversion R-HSA-75064 4.136743e-01 0.383 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.136743e-01 0.383 0 0
C6 deamination of adenosine R-HSA-75102 4.136743e-01 0.383 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 4.136743e-01 0.383 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.853984e-01 0.414 0 0
MET activates STAT3 R-HSA-8875791 4.869442e-01 0.313 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.869442e-01 0.313 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.869442e-01 0.313 0 0
DAG and IP3 signaling R-HSA-1489509 2.802771e-01 0.552 0 0
PLC beta mediated events R-HSA-112043 3.187697e-01 0.497 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 4.988708e-01 0.302 0 0
Intraflagellar transport R-HSA-5620924 4.715811e-01 0.326 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 5.001281e-01 0.301 0 0
Platelet calcium homeostasis R-HSA-418360 5.001281e-01 0.301 0 0
Degradation of CDH1 R-HSA-9766229 4.911094e-01 0.309 0 0
Signaling by PTK6 R-HSA-8848021 3.514662e-01 0.454 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.514662e-01 0.454 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 4.224708e-01 0.374 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 2.806538e-01 0.552 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 4.239081e-01 0.373 0 0
HCMV Late Events R-HSA-9610379 3.179360e-01 0.498 0 0
Amine ligand-binding receptors R-HSA-375280 3.922690e-01 0.406 0 0
Frs2-mediated activation R-HSA-170968 3.956843e-01 0.403 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 4.750904e-01 0.323 0 0
RET signaling R-HSA-8853659 5.116230e-01 0.291 0 0
PECAM1 interactions R-HSA-210990 2.877268e-01 0.541 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 4.314576e-01 0.365 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 4.756067e-01 0.323 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 4.569165e-01 0.340 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 3.872500e-01 0.412 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 3.350402e-01 0.475 0 0
Prolonged ERK activation events R-HSA-169893 4.988708e-01 0.302 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 4.855799e-01 0.314 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 2.802771e-01 0.552 0 0
Negative regulation of FLT3 R-HSA-9706369 4.988708e-01 0.302 0 0
Ca-dependent events R-HSA-111996 3.525647e-01 0.453 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 4.730056e-01 0.325 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.756067e-01 0.323 0 0
Interleukin-1 processing R-HSA-448706 4.756067e-01 0.323 0 0
Protein hydroxylation R-HSA-9629569 4.277324e-01 0.369 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 5.136117e-01 0.289 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.802771e-01 0.552 0 0
Stimuli-sensing channels R-HSA-2672351 3.416567e-01 0.466 0 0
RUNX2 regulates bone development R-HSA-8941326 5.116230e-01 0.291 0 0
FLT3 Signaling R-HSA-9607240 3.133859e-01 0.504 0 0
DSCAM interactions R-HSA-376172 4.136743e-01 0.383 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 3.238112e-01 0.490 0 0
Intracellular oxygen transport R-HSA-8981607 4.869442e-01 0.313 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 2.681699e-01 0.572 0 0
Maturation of nucleoprotein R-HSA-9683610 3.956843e-01 0.403 0 0
Platelet sensitization by LDL R-HSA-432142 3.683299e-01 0.434 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 4.756067e-01 0.323 0 0
ARMS-mediated activation R-HSA-170984 4.756067e-01 0.323 0 0
Viral Messenger RNA Synthesis R-HSA-168325 3.187697e-01 0.497 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.457293e-01 0.351 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 2.806538e-01 0.552 0 0
Sensory processing of sound R-HSA-9659379 2.777095e-01 0.556 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 2.687827e-01 0.571 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.377835e-01 0.471 0 0
Histamine receptors R-HSA-390650 4.869442e-01 0.313 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 4.199486e-01 0.377 0 0
Signaling by ALK R-HSA-201556 4.160207e-01 0.381 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 2.891076e-01 0.539 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 4.869442e-01 0.313 0 0
Sodium/Proton exchangers R-HSA-425986 4.314576e-01 0.365 0 0
Unfolded Protein Response (UPR) R-HSA-381119 5.135917e-01 0.289 0 0
STING mediated induction of host immune responses R-HSA-1834941 3.981553e-01 0.400 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 4.653700e-01 0.332 0 0
Glucose metabolism R-HSA-70326 3.034286e-01 0.518 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.683299e-01 0.434 0 0
Selenoamino acid metabolism R-HSA-2408522 3.164491e-01 0.500 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.915056e-01 0.407 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 3.956843e-01 0.403 0 0
IRE1alpha activates chaperones R-HSA-381070 4.796064e-01 0.319 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 4.309145e-01 0.366 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 5.190912e-01 0.285 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.246915e-01 0.280 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 5.246915e-01 0.280 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 5.246915e-01 0.280 0 0
Adaptive Immune System R-HSA-1280218 5.259564e-01 0.279 1 0
Phase 2 - plateau phase R-HSA-5576893 5.312718e-01 0.275 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 5.312718e-01 0.275 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.312718e-01 0.275 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 5.312718e-01 0.275 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 5.312718e-01 0.275 0 0
SARS-CoV-2 Infection R-HSA-9694516 5.336796e-01 0.273 0 0
Extension of Telomeres R-HSA-180786 5.368590e-01 0.270 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.368590e-01 0.270 0 0
Interleukin receptor SHC signaling R-HSA-912526 5.409169e-01 0.267 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 5.409169e-01 0.267 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.409169e-01 0.267 0 0
PI Metabolism R-HSA-1483255 5.429303e-01 0.265 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 5.510616e-01 0.259 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.510616e-01 0.259 0 0
Nucleotide catabolism defects R-HSA-9735786 5.510616e-01 0.259 0 0
ATP sensitive Potassium channels R-HSA-1296025 5.510616e-01 0.259 0 0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine R-HSA-9735763 5.510616e-01 0.259 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 5.510616e-01 0.259 0 0
Signaling by MAP2K mutants R-HSA-9652169 5.510616e-01 0.259 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 5.510616e-01 0.259 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.510616e-01 0.259 0 0
Dopamine receptors R-HSA-390651 5.510616e-01 0.259 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 5.510616e-01 0.259 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.510616e-01 0.259 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 5.572976e-01 0.254 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 5.572976e-01 0.254 0 0
FGFR2b ligand binding and activation R-HSA-190377 5.572976e-01 0.254 0 0
Formation of the posterior neural plate R-HSA-9832991 5.572976e-01 0.254 0 0
Chylomicron assembly R-HSA-8963888 5.572976e-01 0.254 0 0
Ionotropic activity of kainate receptors R-HSA-451306 5.572976e-01 0.254 0 0
Suppression of apoptosis R-HSA-9635465 5.572976e-01 0.254 0 0
Prostanoid ligand receptors R-HSA-391908 5.572976e-01 0.254 0 0
ChREBP activates metabolic gene expression R-HSA-163765 5.572976e-01 0.254 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 5.624600e-01 0.250 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 5.624600e-01 0.250 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 5.624600e-01 0.250 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 5.624600e-01 0.250 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 5.624600e-01 0.250 0 0
Uptake and function of anthrax toxins R-HSA-5210891 5.624600e-01 0.250 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 5.624600e-01 0.250 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 5.653014e-01 0.248 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 5.674159e-01 0.246 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 5.674159e-01 0.246 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 5.674159e-01 0.246 0 0
G0 and Early G1 R-HSA-1538133 5.721337e-01 0.243 0 0
Stabilization of p53 R-HSA-69541 5.766135e-01 0.239 0 0
Rab regulation of trafficking R-HSA-9007101 5.785236e-01 0.238 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 5.808729e-01 0.236 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 5.808729e-01 0.236 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 5.864579e-01 0.232 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.888155e-01 0.230 0 0
Signaling by Hedgehog R-HSA-5358351 5.900650e-01 0.229 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 5.923506e-01 0.227 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 5.923506e-01 0.227 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 5.923506e-01 0.227 0 0
Mismatch Repair R-HSA-5358508 5.923506e-01 0.227 0 0
Chaperone Mediated Autophagy R-HSA-9613829 5.923506e-01 0.227 0 0
FGFR1 ligand binding and activation R-HSA-190242 5.923506e-01 0.227 0 0
PKA activation in glucagon signalling R-HSA-164378 5.923506e-01 0.227 0 0
PKA activation R-HSA-163615 5.923506e-01 0.227 0 0
Tie2 Signaling R-HSA-210993 5.923506e-01 0.227 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 5.923506e-01 0.227 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 5.927003e-01 0.227 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 5.927003e-01 0.227 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 5.927003e-01 0.227 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 5.930438e-01 0.227 0 0
Tight junction interactions R-HSA-420029 5.930438e-01 0.227 0 0
Formation of the nephric duct R-HSA-9830364 5.930438e-01 0.227 0 0
Interleukin-7 signaling R-HSA-1266695 5.930438e-01 0.227 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 5.946076e-01 0.226 0 0
Integration of provirus R-HSA-162592 5.946076e-01 0.226 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 5.946076e-01 0.226 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 5.946076e-01 0.226 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 5.946076e-01 0.226 0 0
NF-kB is activated and signals survival R-HSA-209560 5.946076e-01 0.226 0 0
G-protein beta:gamma signalling R-HSA-397795 5.949037e-01 0.226 0 0
FGFR1 mutant receptor activation R-HSA-1839124 5.949037e-01 0.226 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 5.972951e-01 0.224 0 0
Generation of second messenger molecules R-HSA-202433 5.972951e-01 0.224 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 6.027063e-01 0.220 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 6.027063e-01 0.220 0 0
Signaling by NOTCH3 R-HSA-9012852 6.027063e-01 0.220 0 0
Protein folding R-HSA-391251 6.028952e-01 0.220 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 6.031477e-01 0.220 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 6.031477e-01 0.220 0 0
Activation of AMPA receptors R-HSA-399710 6.071694e-01 0.217 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 6.071694e-01 0.217 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.071694e-01 0.217 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 6.071694e-01 0.217 0 0
Activation of AKT2 R-HSA-165158 6.071694e-01 0.217 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 6.071694e-01 0.217 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 6.071694e-01 0.217 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 6.071694e-01 0.217 0 0
Suppression of autophagy R-HSA-9636569 6.071694e-01 0.217 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 6.071694e-01 0.217 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.071694e-01 0.217 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 6.071694e-01 0.217 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 6.071694e-01 0.217 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 6.071694e-01 0.217 0 0
Hedgehog 'on' state R-HSA-5632684 6.083365e-01 0.216 0 0
Hemostasis R-HSA-109582 6.088598e-01 0.215 1 0
Co-inhibition by PD-1 R-HSA-389948 6.156488e-01 0.211 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 6.156488e-01 0.211 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 6.166415e-01 0.210 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 6.174242e-01 0.209 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 6.177492e-01 0.209 0 0
Regulation of signaling by CBL R-HSA-912631 6.208843e-01 0.207 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.208843e-01 0.207 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.208843e-01 0.207 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.208843e-01 0.207 0 0
Maturation of nucleoprotein R-HSA-9694631 6.208843e-01 0.207 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 6.208843e-01 0.207 0 0
Synthesis of DNA R-HSA-69239 6.219769e-01 0.206 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 6.238292e-01 0.205 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 6.238292e-01 0.205 0 0
Signaling by MET R-HSA-6806834 6.258835e-01 0.204 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 6.271307e-01 0.203 0 0
MET activates RAS signaling R-HSA-8851805 6.295098e-01 0.201 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 6.295098e-01 0.201 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 6.295098e-01 0.201 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 6.295098e-01 0.201 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 6.295098e-01 0.201 0 0
Estrogen biosynthesis R-HSA-193144 6.295098e-01 0.201 0 0
Regulation of IFNG signaling R-HSA-877312 6.295098e-01 0.201 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 6.295098e-01 0.201 0 0
Developmental Cell Lineages R-HSA-9734767 6.365319e-01 0.196 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 6.383325e-01 0.195 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 6.383325e-01 0.195 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 6.388604e-01 0.195 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 6.388604e-01 0.195 0 0
Ca2+ pathway R-HSA-4086398 6.390001e-01 0.194 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 6.414931e-01 0.193 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 6.414931e-01 0.193 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 6.414931e-01 0.193 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 6.480239e-01 0.188 0 0
Signaling by NOTCH4 R-HSA-9013694 6.538351e-01 0.185 0 0
Signaling by ERBB4 R-HSA-1236394 6.538351e-01 0.185 0 0
PI3K Cascade R-HSA-109704 6.542973e-01 0.184 0 0
TRAIL signaling R-HSA-75158 6.562678e-01 0.183 0 0
Plus-strand DNA synthesis R-HSA-164525 6.562678e-01 0.183 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 6.562678e-01 0.183 0 0
PDE3B signalling R-HSA-165160 6.562678e-01 0.183 0 0
PKB-mediated events R-HSA-109703 6.562678e-01 0.183 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.562678e-01 0.183 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.562678e-01 0.183 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 6.562678e-01 0.183 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.562678e-01 0.183 0 0
Signaling by MAPK mutants R-HSA-9652817 6.562678e-01 0.183 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 6.562678e-01 0.183 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.562678e-01 0.183 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.562678e-01 0.183 0 0
Synthesis of PS R-HSA-1483101 6.562678e-01 0.183 0 0
Formation of the Editosome R-HSA-75094 6.562678e-01 0.183 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.562678e-01 0.183 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.562678e-01 0.183 0 0
Ceramide signalling R-HSA-193681 6.562678e-01 0.183 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 6.562678e-01 0.183 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.562678e-01 0.183 0 0
VEGF ligand-receptor interactions R-HSA-194313 6.562678e-01 0.183 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.562678e-01 0.183 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 6.562678e-01 0.183 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 6.562678e-01 0.183 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 6.562678e-01 0.183 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.562678e-01 0.183 0 0
Parasitic Infection Pathways R-HSA-9824443 6.568918e-01 0.183 0 0
Leishmania infection R-HSA-9658195 6.568918e-01 0.183 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 6.589307e-01 0.181 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 6.589307e-01 0.181 0 0
PERK regulates gene expression R-HSA-381042 6.589307e-01 0.181 0 0
FGFR2c ligand binding and activation R-HSA-190375 6.620232e-01 0.179 0 0
Chylomicron remodeling R-HSA-8963901 6.620232e-01 0.179 0 0
FGFR4 ligand binding and activation R-HSA-190322 6.620232e-01 0.179 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 6.620232e-01 0.179 0 0
FGFR3 mutant receptor activation R-HSA-2033514 6.620232e-01 0.179 0 0
CD28 dependent Vav1 pathway R-HSA-389359 6.620232e-01 0.179 0 0
Interleukin-6 signaling R-HSA-1059683 6.620232e-01 0.179 0 0
Telomere Extension By Telomerase R-HSA-171319 6.642480e-01 0.178 0 0
HIV elongation arrest and recovery R-HSA-167287 6.642480e-01 0.178 0 0
Pausing and recovery of HIV elongation R-HSA-167290 6.642480e-01 0.178 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 6.642480e-01 0.178 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 6.678683e-01 0.175 0 0
Interleukin-1 family signaling R-HSA-446652 6.678683e-01 0.175 0 0
Signaling by TGFB family members R-HSA-9006936 6.694462e-01 0.174 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 6.737512e-01 0.172 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 6.737512e-01 0.172 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 6.737512e-01 0.172 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 6.737512e-01 0.172 0 0
Basigin interactions R-HSA-210991 6.737512e-01 0.172 0 0
Signaling by SCF-KIT R-HSA-1433557 6.742345e-01 0.171 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 6.787561e-01 0.168 0 0
RNA Polymerase III Transcription R-HSA-74158 6.787561e-01 0.168 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 6.787561e-01 0.168 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 6.818485e-01 0.166 0 0
Transcription of the HIV genome R-HSA-167172 6.835447e-01 0.165 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 6.835447e-01 0.165 0 0
Signaling by Erythropoietin R-HSA-9006335 6.859966e-01 0.164 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.859966e-01 0.164 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 6.859966e-01 0.164 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 6.879616e-01 0.162 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 6.879616e-01 0.162 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 6.879616e-01 0.162 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 6.921997e-01 0.160 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 6.921997e-01 0.160 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 6.921997e-01 0.160 0 0
CRMPs in Sema3A signaling R-HSA-399956 6.921997e-01 0.160 0 0
FGFR3c ligand binding and activation R-HSA-190372 6.921997e-01 0.160 0 0
Zinc transporters R-HSA-435354 6.921997e-01 0.160 0 0
Non-canonical inflammasome activation R-HSA-9686114 6.921997e-01 0.160 0 0
Signaling by FGFR R-HSA-190236 6.939034e-01 0.159 0 0
Regulation of insulin secretion R-HSA-422356 6.939034e-01 0.159 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 6.958236e-01 0.158 0 0
Parasite infection R-HSA-9664407 6.958236e-01 0.158 0 0
Leishmania phagocytosis R-HSA-9664417 6.958236e-01 0.158 0 0
Ovarian tumor domain proteases R-HSA-5689896 6.977954e-01 0.156 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 6.980645e-01 0.156 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 6.980645e-01 0.156 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.980645e-01 0.156 0 0
Mitochondrial calcium ion transport R-HSA-8949215 6.980645e-01 0.156 0 0
Signaling by LTK in cancer R-HSA-9842640 6.992321e-01 0.155 0 0
STAT5 Activation R-HSA-9645135 6.992321e-01 0.155 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.992321e-01 0.155 0 0
Autointegration results in viral DNA circles R-HSA-177539 6.992321e-01 0.155 0 0
Uncoating of the HIV Virion R-HSA-162585 6.992321e-01 0.155 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 6.992321e-01 0.155 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.992321e-01 0.155 0 0
MET Receptor Activation R-HSA-6806942 6.992321e-01 0.155 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.992321e-01 0.155 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.992321e-01 0.155 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 6.992321e-01 0.155 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 6.992321e-01 0.155 0 0
Abacavir transmembrane transport R-HSA-2161517 6.992321e-01 0.155 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.992321e-01 0.155 0 0
NADPH regeneration R-HSA-389542 6.992321e-01 0.155 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 6.992321e-01 0.155 0 0
Nef and signal transduction R-HSA-164944 6.992321e-01 0.155 0 0
VLDL assembly R-HSA-8866423 6.992321e-01 0.155 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.004553e-01 0.155 0 0
MAP kinase activation R-HSA-450294 7.004553e-01 0.155 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 7.039803e-01 0.152 0 0
Smooth Muscle Contraction R-HSA-445355 7.039803e-01 0.152 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 7.058025e-01 0.151 0 0
DAP12 signaling R-HSA-2424491 7.067310e-01 0.151 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.067310e-01 0.151 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 7.067310e-01 0.151 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 7.067310e-01 0.151 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 7.119462e-01 0.148 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 7.119462e-01 0.148 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 7.151328e-01 0.146 0 0
Signaling by PDGF R-HSA-186797 7.151328e-01 0.146 0 0
Gastrulation R-HSA-9758941 7.158476e-01 0.145 0 0
MET promotes cell motility R-HSA-8875878 7.160409e-01 0.145 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 7.201153e-01 0.143 0 0
Erythropoietin activates RAS R-HSA-9027284 7.201153e-01 0.143 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 7.201153e-01 0.143 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 7.201153e-01 0.143 0 0
Translesion synthesis by REV1 R-HSA-110312 7.201153e-01 0.143 0 0
SHC1 events in EGFR signaling R-HSA-180336 7.201153e-01 0.143 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 7.201153e-01 0.143 0 0
FGFR3 ligand binding and activation R-HSA-190239 7.201153e-01 0.143 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 7.201153e-01 0.143 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 7.201153e-01 0.143 0 0
Protein methylation R-HSA-8876725 7.201153e-01 0.143 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.209760e-01 0.142 0 0
FGFR2 alternative splicing R-HSA-6803529 7.209760e-01 0.142 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 7.209760e-01 0.142 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.209760e-01 0.142 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.209760e-01 0.142 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.209760e-01 0.142 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 7.253275e-01 0.139 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.253568e-01 0.139 1 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 7.264511e-01 0.139 0 0
Budding and maturation of HIV virion R-HSA-162588 7.264511e-01 0.139 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.264511e-01 0.139 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.275755e-01 0.138 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 7.334904e-01 0.135 0 0
Integration of energy metabolism R-HSA-163685 7.348951e-01 0.134 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 7.368283e-01 0.133 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 7.368283e-01 0.133 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 7.368283e-01 0.133 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.368283e-01 0.133 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 7.368283e-01 0.133 0 0
FGFR3b ligand binding and activation R-HSA-190371 7.368283e-01 0.133 0 0
Recycling of eIF2:GDP R-HSA-72731 7.368283e-01 0.133 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 7.368283e-01 0.133 0 0
mRNA Editing: C to U Conversion R-HSA-72200 7.368283e-01 0.133 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.368283e-01 0.133 0 0
Cysteine formation from homocysteine R-HSA-1614603 7.368283e-01 0.133 0 0
VLDL clearance R-HSA-8964046 7.368283e-01 0.133 0 0
LDL remodeling R-HSA-8964041 7.368283e-01 0.133 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 7.368283e-01 0.133 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 7.368283e-01 0.133 0 0
CHL1 interactions R-HSA-447041 7.368283e-01 0.133 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.382954e-01 0.132 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 7.410495e-01 0.130 0 0
Growth hormone receptor signaling R-HSA-982772 7.425093e-01 0.129 0 0
Insulin receptor signalling cascade R-HSA-74751 7.430324e-01 0.129 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.451644e-01 0.128 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 7.451644e-01 0.128 0 0
Translesion synthesis by POLI R-HSA-5656121 7.458638e-01 0.127 0 0
Atorvastatin ADME R-HSA-9754706 7.458638e-01 0.127 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 7.458638e-01 0.127 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 7.458638e-01 0.127 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.487001e-01 0.126 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 7.487001e-01 0.126 0 0
HIV Transcription Elongation R-HSA-167169 7.501461e-01 0.125 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 7.501461e-01 0.125 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 7.501461e-01 0.125 0 0
Glycogen metabolism R-HSA-8982491 7.501461e-01 0.125 0 0
Attenuation phase R-HSA-3371568 7.501461e-01 0.125 0 0
Interleukin-2 family signaling R-HSA-451927 7.501461e-01 0.125 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.501461e-01 0.125 0 0
Diseases of Immune System R-HSA-5260271 7.501461e-01 0.125 0 0
IRS-mediated signalling R-HSA-112399 7.624877e-01 0.118 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.626972e-01 0.118 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 7.626972e-01 0.118 0 0
Plasma lipoprotein assembly R-HSA-8963898 7.626972e-01 0.118 0 0
G1/S Transition R-HSA-69206 7.650476e-01 0.116 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 7.660147e-01 0.116 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 7.695506e-01 0.114 0 0
Translesion synthesis by POLK R-HSA-5655862 7.695506e-01 0.114 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 7.695506e-01 0.114 0 0
Passive transport by Aquaporins R-HSA-432047 7.695506e-01 0.114 0 0
Galactose catabolism R-HSA-70370 7.695506e-01 0.114 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 7.695506e-01 0.114 0 0
Synthesis of PG R-HSA-1483148 7.695506e-01 0.114 0 0
Response to metal ions R-HSA-5660526 7.695506e-01 0.114 0 0
Reverse Transcription of HIV RNA R-HSA-162589 7.697268e-01 0.114 0 0
Minus-strand DNA synthesis R-HSA-164516 7.697268e-01 0.114 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 7.697268e-01 0.114 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.697268e-01 0.114 0 0
MET receptor recycling R-HSA-8875656 7.697268e-01 0.114 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.697268e-01 0.114 0 0
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597 7.697268e-01 0.114 0 0
Regulation by c-FLIP R-HSA-3371378 7.697268e-01 0.114 0 0
Fructose biosynthesis R-HSA-5652227 7.697268e-01 0.114 0 0
Co-stimulation by ICOS R-HSA-9927354 7.697268e-01 0.114 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.697268e-01 0.114 1 1
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.697268e-01 0.114 0 0
Dimerization of procaspase-8 R-HSA-69416 7.697268e-01 0.114 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.697268e-01 0.114 0 0
Alpha-defensins R-HSA-1462054 7.697268e-01 0.114 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.697268e-01 0.114 0 0
Interleukin-23 signaling R-HSA-9020933 7.697268e-01 0.114 0 0
Protein ubiquitination R-HSA-8852135 7.754393e-01 0.110 0 0
G alpha (s) signalling events R-HSA-418555 7.755894e-01 0.110 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.761238e-01 0.110 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.783930e-01 0.109 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 7.784271e-01 0.109 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 7.796289e-01 0.108 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.796289e-01 0.108 0 0
Nucleotide Excision Repair R-HSA-5696398 7.810724e-01 0.107 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 7.811065e-01 0.107 0 0
Signaling by FGFR1 in disease R-HSA-5655302 7.811065e-01 0.107 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 7.811065e-01 0.107 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.815801e-01 0.107 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 7.815801e-01 0.107 0 0
Ion channel transport R-HSA-983712 7.891348e-01 0.103 0 0
Platelet homeostasis R-HSA-418346 7.906205e-01 0.102 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 7.912887e-01 0.102 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 7.912887e-01 0.102 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 7.912887e-01 0.102 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 7.912887e-01 0.102 0 0
Dual Incision in GG-NER R-HSA-5696400 7.954219e-01 0.099 0 0
NOD1/2 Signaling Pathway R-HSA-168638 7.954219e-01 0.099 0 0
Signaling by NOTCH2 R-HSA-1980145 7.954219e-01 0.099 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.985145e-01 0.098 0 0
Lipophagy R-HSA-9613354 7.985145e-01 0.098 0 0
CASP8 activity is inhibited R-HSA-5218900 7.985145e-01 0.098 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.985145e-01 0.098 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.985145e-01 0.098 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.985145e-01 0.098 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.985145e-01 0.098 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 7.985145e-01 0.098 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.985145e-01 0.098 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.985145e-01 0.098 0 0
WNT mediated activation of DVL R-HSA-201688 7.985145e-01 0.098 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.985145e-01 0.098 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.985145e-01 0.098 0 0
Cellular response to mitochondrial stress R-HSA-9840373 7.985145e-01 0.098 0 0
MET activates PTK2 signaling R-HSA-8874081 7.992043e-01 0.097 0 0
Signaling by EGFR in Cancer R-HSA-1643713 7.992043e-01 0.097 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.992043e-01 0.097 0 0
SARS-CoV Infections R-HSA-9679506 8.027141e-01 0.095 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 8.055281e-01 0.094 0 0
Response of Mtb to phagocytosis R-HSA-9637690 8.090163e-01 0.092 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.099355e-01 0.092 0 0
G alpha (q) signalling events R-HSA-416476 8.105546e-01 0.091 0 0
Activated point mutants of FGFR2 R-HSA-2033519 8.111952e-01 0.091 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 8.111952e-01 0.091 0 0
Viral Infection Pathways R-HSA-9824446 8.146591e-01 0.089 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 8.150713e-01 0.089 1 0
Interleukin-17 signaling R-HSA-448424 8.150713e-01 0.089 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 8.156204e-01 0.089 0 0
Cristae formation R-HSA-8949613 8.156204e-01 0.089 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.211157e-01 0.086 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 8.218288e-01 0.085 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.218288e-01 0.085 0 0
DAP12 interactions R-HSA-2172127 8.218693e-01 0.085 0 0
DNA replication initiation R-HSA-68952 8.237047e-01 0.084 0 0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 8.237047e-01 0.084 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 8.237047e-01 0.084 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 8.237047e-01 0.084 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 8.237047e-01 0.084 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.237047e-01 0.084 0 0
2-LTR circle formation R-HSA-164843 8.237047e-01 0.084 0 0
Maturation of spike protein R-HSA-9683686 8.237047e-01 0.084 0 0
Formation of apoptosome R-HSA-111458 8.237047e-01 0.084 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.237047e-01 0.084 0 0
Regulation of the apoptosome activity R-HSA-9627069 8.237047e-01 0.084 0 0
Tandem pore domain potassium channels R-HSA-1296346 8.237047e-01 0.084 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.242626e-01 0.084 0 0
FLT3 signaling in disease R-HSA-9682385 8.242626e-01 0.084 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 8.258325e-01 0.083 0 0
MyD88-independent TLR4 cascade R-HSA-166166 8.258325e-01 0.083 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 8.293880e-01 0.081 0 0
Translesion Synthesis by POLH R-HSA-110320 8.293880e-01 0.081 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 8.293880e-01 0.081 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.308821e-01 0.080 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.308821e-01 0.080 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 8.331239e-01 0.079 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.340145e-01 0.079 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.340145e-01 0.079 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 8.353087e-01 0.078 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 8.373719e-01 0.077 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.450452e-01 0.073 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 8.450452e-01 0.073 0 0
DARPP-32 events R-HSA-180024 8.450452e-01 0.073 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.454742e-01 0.073 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 8.457468e-01 0.073 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.457468e-01 0.073 0 0
Synthesis of PI R-HSA-1483226 8.457468e-01 0.073 0 0
Bicarbonate transporters R-HSA-425381 8.457468e-01 0.073 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 8.457468e-01 0.073 0 0
Transport of RCbl within the body R-HSA-9758890 8.457468e-01 0.073 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 8.457468e-01 0.073 0 0
LGI-ADAM interactions R-HSA-5682910 8.457468e-01 0.073 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.457468e-01 0.073 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.457468e-01 0.073 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.457468e-01 0.073 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 8.459845e-01 0.073 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 8.459845e-01 0.073 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 8.459845e-01 0.073 0 0
Glycogen synthesis R-HSA-3322077 8.459845e-01 0.073 0 0
Signaling by NODAL R-HSA-1181150 8.459845e-01 0.073 0 0
Pregnenolone biosynthesis R-HSA-196108 8.459845e-01 0.073 0 0
Nephrin family interactions R-HSA-373753 8.459845e-01 0.073 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 8.459845e-01 0.073 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 8.509721e-01 0.070 0 0
Cellular response to hypoxia R-HSA-1234174 8.533325e-01 0.069 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 8.536231e-01 0.069 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 8.562719e-01 0.067 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 8.562719e-01 0.067 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.581667e-01 0.066 0 0
G-protein activation R-HSA-202040 8.610994e-01 0.065 0 0
FGFR2 ligand binding and activation R-HSA-190241 8.610994e-01 0.065 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 8.610994e-01 0.065 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 8.610994e-01 0.065 0 0
ERK/MAPK targets R-HSA-198753 8.610994e-01 0.065 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 8.610994e-01 0.065 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 8.610994e-01 0.065 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 8.623493e-01 0.064 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.623493e-01 0.064 0 0
Immune System R-HSA-168256 8.637278e-01 0.064 1 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 8.650342e-01 0.063 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.650342e-01 0.063 0 0
ERKs are inactivated R-HSA-202670 8.650342e-01 0.063 0 0
Sodium/Calcium exchangers R-HSA-425561 8.650342e-01 0.063 0 0
Plasma lipoprotein remodeling R-HSA-8963899 8.664321e-01 0.062 0 0
Metal ion SLC transporters R-HSA-425410 8.664321e-01 0.062 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.703036e-01 0.060 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.703036e-01 0.060 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.718630e-01 0.060 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.718630e-01 0.060 0 0
Dual incision in TC-NER R-HSA-6782135 8.726538e-01 0.059 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.726538e-01 0.059 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 8.748436e-01 0.058 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 8.759798e-01 0.058 0 0
Interferon alpha/beta signaling R-HSA-909733 8.764755e-01 0.057 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 8.782425e-01 0.056 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.819109e-01 0.055 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.819109e-01 0.055 0 0
Repression of WNT target genes R-HSA-4641265 8.819109e-01 0.055 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.819109e-01 0.055 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.819109e-01 0.055 0 0
Interleukin-15 signaling R-HSA-8983432 8.819109e-01 0.055 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.819109e-01 0.055 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.819109e-01 0.055 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.819109e-01 0.055 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.819109e-01 0.055 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 8.852971e-01 0.053 0 0
TCR signaling R-HSA-202403 8.872656e-01 0.052 0 0
Signaling by KIT in disease R-HSA-9669938 8.873235e-01 0.052 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 8.873235e-01 0.052 0 0
Free fatty acid receptors R-HSA-444209 8.873235e-01 0.052 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 8.873235e-01 0.052 0 0
Fructose metabolism R-HSA-5652084 8.873235e-01 0.052 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 8.873235e-01 0.052 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 8.873235e-01 0.052 0 0
Intra-Golgi traffic R-HSA-6811438 8.911837e-01 0.050 0 0
Translation of Structural Proteins R-HSA-9683701 8.911837e-01 0.050 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.918508e-01 0.050 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.919676e-01 0.050 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 8.942007e-01 0.049 0 0
Toll-like Receptor Cascades R-HSA-168898 8.963680e-01 0.048 0 0
Acetylcholine binding and downstream events R-HSA-181431 8.966781e-01 0.047 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 8.966781e-01 0.047 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.966781e-01 0.047 0 0
Diseases of nucleotide metabolism R-HSA-9735804 8.966781e-01 0.047 0 0
Mtb iron assimilation by chelation R-HSA-1222449 8.966781e-01 0.047 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.966781e-01 0.047 0 0
Processing of SMDT1 R-HSA-8949664 8.966781e-01 0.047 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 8.966781e-01 0.047 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.966781e-01 0.047 0 0
GPCR downstream signalling R-HSA-388396 8.968212e-01 0.047 1 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.968838e-01 0.047 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 8.986404e-01 0.046 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 8.986404e-01 0.046 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 8.986404e-01 0.046 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 8.986404e-01 0.046 0 0
Syndecan interactions R-HSA-3000170 8.986404e-01 0.046 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 8.998503e-01 0.046 0 0
Platelet degranulation R-HSA-114608 9.007195e-01 0.045 0 0
Orc1 removal from chromatin R-HSA-68949 9.012055e-01 0.045 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.012055e-01 0.045 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.013720e-01 0.045 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.039389e-01 0.044 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.040322e-01 0.044 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.088898e-01 0.041 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.088898e-01 0.041 0 0
Complex III assembly R-HSA-9865881 9.088898e-01 0.041 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.088898e-01 0.041 0 0
Interleukin-6 family signaling R-HSA-6783589 9.088898e-01 0.041 0 0
Retrograde neurotrophin signalling R-HSA-177504 9.095994e-01 0.041 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 9.095994e-01 0.041 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 9.095994e-01 0.041 0 0
N-glycan trimming and elongation in the cis-Golgi R-HSA-964739 9.095994e-01 0.041 0 0
Physiological factors R-HSA-5578768 9.095994e-01 0.041 0 0
Prolactin receptor signaling R-HSA-1170546 9.095994e-01 0.041 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.095994e-01 0.041 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 9.095994e-01 0.041 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 9.095994e-01 0.041 0 0
HDL assembly R-HSA-8963896 9.095994e-01 0.041 0 0
P2Y receptors R-HSA-417957 9.095994e-01 0.041 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.101297e-01 0.041 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.101297e-01 0.041 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.101297e-01 0.041 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.147798e-01 0.039 0 0
Ion transport by P-type ATPases R-HSA-936837 9.170546e-01 0.038 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.181617e-01 0.037 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.181617e-01 0.037 0 0
G protein gated Potassium channels R-HSA-1296059 9.181617e-01 0.037 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.181617e-01 0.037 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.181617e-01 0.037 0 0
Regulation of Apoptosis R-HSA-169911 9.181753e-01 0.037 0 0
Vesicle-mediated transport R-HSA-5653656 9.183489e-01 0.037 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.198927e-01 0.036 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 9.209055e-01 0.036 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 9.209055e-01 0.036 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.209055e-01 0.036 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.209055e-01 0.036 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 9.209055e-01 0.036 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 9.209055e-01 0.036 0 0
Transport and metabolism of PAPS R-HSA-174362 9.209055e-01 0.036 0 0
Biotin transport and metabolism R-HSA-196780 9.209055e-01 0.036 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 9.209055e-01 0.036 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.209055e-01 0.036 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.222982e-01 0.035 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.222982e-01 0.035 0 0
G1/S-Specific Transcription R-HSA-69205 9.255580e-01 0.034 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.255580e-01 0.034 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.255580e-01 0.034 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.265403e-01 0.033 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.265403e-01 0.033 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 9.265403e-01 0.033 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 9.275537e-01 0.033 0 0
TNF signaling R-HSA-75893 9.278225e-01 0.033 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.287098e-01 0.032 0 0
Interleukin-1 signaling R-HSA-9020702 9.290883e-01 0.032 0 0
Activation of the phototransduction cascade R-HSA-2485179 9.307981e-01 0.031 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 9.307981e-01 0.031 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 9.307981e-01 0.031 0 0
Differentiation of T cells R-HSA-9945266 9.307981e-01 0.031 0 0
Killing mechanisms R-HSA-9664420 9.307981e-01 0.031 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 9.307981e-01 0.031 0 0
Fructose catabolism R-HSA-70350 9.307981e-01 0.031 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 9.307981e-01 0.031 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 9.307981e-01 0.031 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.315781e-01 0.031 1 1
TRAF6 mediated IRF7 activation R-HSA-933541 9.323248e-01 0.030 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 9.341039e-01 0.030 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.341039e-01 0.030 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.341039e-01 0.030 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.341039e-01 0.030 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.341039e-01 0.030 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.341039e-01 0.030 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.341039e-01 0.030 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.385206e-01 0.028 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.385206e-01 0.028 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.394539e-01 0.027 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.394539e-01 0.027 0 0
Scavenging by Class B Receptors R-HSA-3000471 9.394539e-01 0.027 0 0
Vitamin B6 activation to pyridoxal phosphate R-HSA-964975 9.394539e-01 0.027 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.394539e-01 0.027 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 9.394539e-01 0.027 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 9.409253e-01 0.026 0 0
Formation of the Early Elongation Complex R-HSA-113418 9.409253e-01 0.026 0 0
Prednisone ADME R-HSA-9757110 9.409253e-01 0.026 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.436987e-01 0.025 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.441878e-01 0.025 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 9.441878e-01 0.025 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.441878e-01 0.025 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.464423e-01 0.024 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.470275e-01 0.024 0 0
Glycogen storage diseases R-HSA-3229121 9.470275e-01 0.024 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.470275e-01 0.024 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.470275e-01 0.024 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.470275e-01 0.024 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.470275e-01 0.024 0 0
mRNA Capping R-HSA-72086 9.470717e-01 0.024 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.470717e-01 0.024 0 0
Regulation of gene expression in beta cells R-HSA-210745 9.470717e-01 0.024 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.493663e-01 0.023 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.493663e-01 0.023 0 0
Aquaporin-mediated transport R-HSA-445717 9.520046e-01 0.021 0 0
Neurotransmitter clearance R-HSA-112311 9.526053e-01 0.021 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.526053e-01 0.021 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.533565e-01 0.021 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 9.536541e-01 0.021 1 1
G beta:gamma signalling through PLC beta R-HSA-418217 9.536541e-01 0.021 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.536541e-01 0.021 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.536541e-01 0.021 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 9.536541e-01 0.021 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.536541e-01 0.021 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.540940e-01 0.020 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.540940e-01 0.020 0 0
Maturation of spike protein R-HSA-9694548 9.540940e-01 0.020 0 0
The phototransduction cascade R-HSA-2514856 9.541363e-01 0.020 0 0
Formation of the cornified envelope R-HSA-6809371 9.551946e-01 0.020 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.575831e-01 0.019 0 0
Cargo concentration in the ER R-HSA-5694530 9.575831e-01 0.019 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.584062e-01 0.018 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.584062e-01 0.018 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.584062e-01 0.018 0 0
HIV Transcription Initiation R-HSA-167161 9.584062e-01 0.018 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.584062e-01 0.018 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.584062e-01 0.018 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.594521e-01 0.018 0 0
Methionine salvage pathway R-HSA-1237112 9.594521e-01 0.018 0 0
HDL remodeling R-HSA-8964058 9.594521e-01 0.018 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.594521e-01 0.018 0 0
Other interleukin signaling R-HSA-449836 9.594521e-01 0.018 0 0
Signaling by Insulin receptor R-HSA-74752 9.613862e-01 0.017 0 0
Signaling by FGFR in disease R-HSA-1226099 9.615362e-01 0.017 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 9.623360e-01 0.017 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.623360e-01 0.017 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.644988e-01 0.016 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.645250e-01 0.016 0 0
Creatine metabolism R-HSA-71288 9.645250e-01 0.016 0 0
Keratan sulfate degradation R-HSA-2022857 9.645250e-01 0.016 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.645250e-01 0.016 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.659144e-01 0.015 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.659144e-01 0.015 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.660768e-01 0.015 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.660768e-01 0.015 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 9.689635e-01 0.014 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.691703e-01 0.014 0 0
Surfactant metabolism R-HSA-5683826 9.691703e-01 0.014 0 0
Heme degradation R-HSA-189483 9.696845e-01 0.013 0 0
Translation of Structural Proteins R-HSA-9694635 9.698070e-01 0.013 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.702774e-01 0.013 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.709570e-01 0.013 0 0
Signaling by GPCR R-HSA-372790 9.717759e-01 0.012 1 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.721304e-01 0.012 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.721304e-01 0.012 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.721304e-01 0.012 0 0
Integrin cell surface interactions R-HSA-216083 9.721780e-01 0.012 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.728469e-01 0.012 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.728469e-01 0.012 0 0
Glutathione synthesis and recycling R-HSA-174403 9.728469e-01 0.012 0 0
Ribavirin ADME R-HSA-9755088 9.728469e-01 0.012 0 0
Assembly Of The HIV Virion R-HSA-175474 9.728469e-01 0.012 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.729208e-01 0.012 0 0
Synthesis of PA R-HSA-1483166 9.735388e-01 0.012 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.735812e-01 0.012 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.736048e-01 0.012 0 0
Regulation of TNFR1 signaling R-HSA-5357905 9.748197e-01 0.011 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.748197e-01 0.011 0 0
SLC transporter disorders R-HSA-5619102 9.750523e-01 0.011 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.758221e-01 0.011 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 9.762446e-01 0.010 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.762446e-01 0.010 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.762446e-01 0.010 0 0
Ethanol oxidation R-HSA-71384 9.762446e-01 0.010 0 0
LDL clearance R-HSA-8964038 9.762446e-01 0.010 0 0
Potential therapeutics for SARS R-HSA-9679191 9.776236e-01 0.010 0 0
Regulation of beta-cell development R-HSA-186712 9.780696e-01 0.010 0 0
HSF1 activation R-HSA-3371511 9.784215e-01 0.009 0 0
Triglyceride catabolism R-HSA-163560 9.784215e-01 0.009 0 0
Glycosphingolipid transport R-HSA-9845576 9.784215e-01 0.009 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.785394e-01 0.009 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.792174e-01 0.009 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.792174e-01 0.009 0 0
Biosynthesis of maresins R-HSA-9018682 9.792174e-01 0.009 0 0
Interleukin-20 family signaling R-HSA-8854691 9.792174e-01 0.009 0 0
RAB geranylgeranylation R-HSA-8873719 9.800507e-01 0.009 0 0
tRNA processing R-HSA-72306 9.803543e-01 0.009 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.807491e-01 0.008 0 0
Degradation of AXIN R-HSA-4641257 9.807491e-01 0.008 0 0
Degradation of DVL R-HSA-4641258 9.807491e-01 0.008 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.807491e-01 0.008 0 0
NCAM1 interactions R-HSA-419037 9.807491e-01 0.008 0 0
Collagen chain trimerization R-HSA-8948216 9.807491e-01 0.008 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.818182e-01 0.008 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.818182e-01 0.008 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.818619e-01 0.008 0 0
Collagen degradation R-HSA-1442490 9.818619e-01 0.008 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.822610e-01 0.008 0 0
Purine salvage R-HSA-74217 9.828323e-01 0.008 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.830325e-01 0.007 1 0
Signaling by FGFR2 in disease R-HSA-5655253 9.833038e-01 0.007 0 0
Mitochondrial protein import R-HSA-1268020 9.835167e-01 0.007 0 0
Hyaluronan degradation R-HSA-2160916 9.840937e-01 0.007 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.840937e-01 0.007 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.846958e-01 0.007 0 0
Mitochondrial protein degradation R-HSA-9837999 9.849205e-01 0.007 0 0
Collagen formation R-HSA-1474290 9.849205e-01 0.007 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.849514e-01 0.007 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.849514e-01 0.007 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.857970e-01 0.006 0 0
Urea cycle R-HSA-70635 9.860846e-01 0.006 0 0
Abacavir ADME R-HSA-2161522 9.860846e-01 0.006 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.864424e-01 0.006 0 0
Interferon gamma signaling R-HSA-877300 9.874537e-01 0.005 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.877910e-01 0.005 0 0
Triglyceride biosynthesis R-HSA-75109 9.878263e-01 0.005 0 0
Insulin processing R-HSA-264876 9.878263e-01 0.005 0 0
Synthesis of PE R-HSA-1483213 9.878263e-01 0.005 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.878263e-01 0.005 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.878508e-01 0.005 0 0
Cholesterol biosynthesis R-HSA-191273 9.892315e-01 0.005 0 0
Pyrimidine salvage R-HSA-73614 9.893502e-01 0.005 0 0
Kidney development R-HSA-9830369 9.898543e-01 0.004 0 0
Metabolism of steroid hormones R-HSA-196071 9.898543e-01 0.004 0 0
ER-Phagosome pathway R-HSA-1236974 9.899648e-01 0.004 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.903682e-01 0.004 0 0
Peptide hormone metabolism R-HSA-2980736 9.906630e-01 0.004 0 0
Thyroxine biosynthesis R-HSA-209968 9.906834e-01 0.004 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.906834e-01 0.004 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.906834e-01 0.004 0 0
Neurotransmitter release cycle R-HSA-112310 9.908094e-01 0.004 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.914280e-01 0.004 0 0
ABC-family proteins mediated transport R-HSA-382556 9.915760e-01 0.004 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.918497e-01 0.004 0 0
Mucopolysaccharidoses R-HSA-2206281 9.918497e-01 0.004 0 0
Proteasome assembly R-HSA-9907900 9.923734e-01 0.003 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.928701e-01 0.003 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.928701e-01 0.003 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.929576e-01 0.003 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.932166e-01 0.003 0 0
Somitogenesis R-HSA-9824272 9.932166e-01 0.003 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.932402e-01 0.003 0 0
Triglyceride metabolism R-HSA-8979227 9.935434e-01 0.003 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.935434e-01 0.003 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.937628e-01 0.003 0 0
HS-GAG degradation R-HSA-2024096 9.937628e-01 0.003 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.938214e-01 0.003 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.942014e-01 0.003 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.942014e-01 0.003 0 0
RSV-host interactions R-HSA-9833110 9.945095e-01 0.002 0 0
Recycling of bile acids and salts R-HSA-159418 9.945438e-01 0.002 0 0
Synthesis of PC R-HSA-1483191 9.946381e-01 0.002 0 0
Nucleotide salvage R-HSA-8956321 9.947941e-01 0.002 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.949470e-01 0.002 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.952270e-01 0.002 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.952270e-01 0.002 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.952270e-01 0.002 0 0
Gluconeogenesis R-HSA-70263 9.952348e-01 0.002 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.953697e-01 0.002 0 0
Neddylation R-HSA-8951664 9.954044e-01 0.002 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.955028e-01 0.002 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.955028e-01 0.002 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.958247e-01 0.002 0 0
eNOS activation R-HSA-203615 9.958247e-01 0.002 0 0
Hyaluronan metabolism R-HSA-2142845 9.958247e-01 0.002 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.963476e-01 0.002 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.963476e-01 0.002 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.963476e-01 0.002 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.966168e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.966350e-01 0.001 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.966602e-01 0.001 1 1
Infectious disease R-HSA-5663205 9.967149e-01 0.001 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.968050e-01 0.001 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.969788e-01 0.001 0 0
Phospholipid metabolism R-HSA-1483257 9.970170e-01 0.001 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.972052e-01 0.001 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.972052e-01 0.001 0 0
Metabolism of folate and pterines R-HSA-196757 9.972052e-01 0.001 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.975552e-01 0.001 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.975552e-01 0.001 0 0
Elastic fibre formation R-HSA-1566948 9.975552e-01 0.001 0 0
Translation R-HSA-72766 9.977704e-01 0.001 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.978615e-01 0.001 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.978615e-01 0.001 0 0
RAS processing R-HSA-9648002 9.978615e-01 0.001 0 0
Protein localization R-HSA-9609507 9.978884e-01 0.001 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.981294e-01 0.001 0 0
Retinoid metabolism and transport R-HSA-975634 9.982598e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.982598e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.983509e-01 0.001 0 0
Metabolism of steroids R-HSA-8957322 9.983542e-01 0.001 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.983637e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.983696e-01 0.001 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.984072e-01 0.001 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.985687e-01 0.001 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.986775e-01 0.001 0 0
Disease R-HSA-1643685 9.986906e-01 0.001 0 0
Peroxisomal protein import R-HSA-9033241 9.987183e-01 0.001 0 0
Pyruvate metabolism R-HSA-70268 9.988096e-01 0.001 0 0
tRNA Aminoacylation R-HSA-379724 9.988639e-01 0.000 0 0
Defensins R-HSA-1461973 9.989049e-01 0.000 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.989335e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.989932e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.990001e-01 0.000 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.990421e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.991156e-01 0.000 0 0
Downstream TCR signaling R-HSA-202424 9.991334e-01 0.000 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.991622e-01 0.000 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.991622e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.992097e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.993000e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.993000e-01 0.000 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.993590e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.993590e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.994339e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.994437e-01 0.000 0 0
Keratan sulfate/keratin metabolism R-HSA-1638074 9.995096e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.995096e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.995141e-01 0.000 0 0
Azathioprine ADME R-HSA-9748787 9.995711e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.996074e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.996249e-01 0.000 0 0
COPII-mediated vesicle transport R-HSA-204005 9.996631e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.996631e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.996631e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.996926e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.997019e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.997019e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.997019e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.997145e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.997346e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.997473e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.997668e-01 0.000 0 0
Paracetamol ADME R-HSA-9753281 9.997805e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.998080e-01 0.000 0 0
Digestion R-HSA-8935690 9.998080e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.998176e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.998176e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.998716e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.998716e-01 0.000 0 0
PCP/CE pathway R-HSA-4086400 9.998740e-01 0.000 1 0
Interleukin-10 signaling R-HSA-6783783 9.998740e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.998877e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.998877e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.999184e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999230e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999249e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999252e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999289e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999289e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999292e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999425e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999437e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999451e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999473e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.999560e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999560e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999574e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999678e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999687e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999775e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999803e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999848e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999863e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999869e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999892e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999912e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999933e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999934e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999955e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999958e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999958e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999958e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999964e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999969e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999970e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999982e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999983e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999994e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999998e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999998e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999998e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999998e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Disinhibition of SNARE formation R-HSA-114516 1.000000e+00 0.000 1 1
WNT5A-dependent internalization of FZD4 R-HSA-5099900 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.110223e-16 15.955 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.110223e-16 15.955 0 0
M Phase R-HSA-68886 1.110223e-16 15.955 1 0
Axon guidance R-HSA-422475 1.110223e-16 15.955 0 0
Nervous system development R-HSA-9675108 1.110223e-16 15.955 0 0
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 1 0
Cell Cycle, Mitotic R-HSA-69278 1.110223e-16 15.955 1 0
Cellular responses to stress R-HSA-2262752 1.110223e-16 15.955 0 0
Cellular responses to stimuli R-HSA-8953897 1.110223e-16 15.955 0 0
Signaling by ROBO receptors R-HSA-376176 1.110223e-16 15.955 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.220446e-16 15.654 0 0
Peptide chain elongation R-HSA-156902 4.440892e-16 15.353 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.443290e-15 14.841 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.443290e-15 14.841 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.665335e-15 14.778 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 5.218048e-15 14.282 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 7.327472e-15 14.135 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.769963e-15 14.010 0 0
Signal Transduction R-HSA-162582 9.547918e-15 14.020 1 0
Ribosome-associated quality control R-HSA-9948299 3.663736e-14 13.436 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 4.507505e-14 13.346 0 0
Eukaryotic Translation Termination R-HSA-72764 1.564304e-13 12.806 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.087219e-13 12.680 0 0
Selenocysteine synthesis R-HSA-2408557 2.615685e-13 12.582 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.901013e-13 12.537 0 0
Mitotic Prophase R-HSA-68875 7.941425e-13 12.100 1 0
Influenza Infection R-HSA-168255 8.695267e-13 12.061 0 0
Viral mRNA Translation R-HSA-192823 1.751932e-12 11.756 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 2.005951e-12 11.698 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.253420e-12 11.647 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.253420e-12 11.647 0 0
Cell-Cell communication R-HSA-1500931 2.903788e-12 11.537 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 3.306244e-12 11.481 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 4.052869e-12 11.392 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 8.459122e-12 11.073 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.305789e-11 10.884 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.516109e-11 10.819 0 0
Developmental Biology R-HSA-1266738 3.388612e-11 10.470 0 0
Cell Cycle Checkpoints R-HSA-69620 3.685363e-11 10.434 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 5.859457e-11 10.232 0 0
Cellular Senescence R-HSA-2559583 6.870982e-11 10.163 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.343483e-10 9.872 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.547190e-10 9.810 0 0
Cell junction organization R-HSA-446728 3.177306e-10 9.498 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 3.275910e-10 9.485 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 3.208549e-10 9.494 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 4.505706e-10 9.346 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 4.937356e-10 9.307 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 6.835499e-10 9.165 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.066939e-09 8.972 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.071874e-09 8.970 0 0
Cellular response to heat stress R-HSA-3371556 1.128456e-09 8.948 0 0
DNA methylation R-HSA-5334118 1.375581e-09 8.862 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.448300e-09 8.839 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.579185e-09 8.802 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.985037e-09 8.702 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.211594e-09 8.655 0 0
Chromatin modifying enzymes R-HSA-3247509 2.553697e-09 8.593 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 4.168168e-09 8.380 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.349222e-09 8.362 1 0
Diseases of programmed cell death R-HSA-9645723 4.661087e-09 8.332 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 5.638072e-09 8.249 0 0
Apoptotic execution phase R-HSA-75153 6.899305e-09 8.161 0 0
Cellular response to starvation R-HSA-9711097 7.284698e-09 8.138 0 0
Chromatin organization R-HSA-4839726 9.439228e-09 8.025 0 0
Meiotic recombination R-HSA-912446 9.288183e-09 8.032 0 0
HSF1-dependent transactivation R-HSA-3371571 9.288183e-09 8.032 0 0
HATs acetylate histones R-HSA-3214847 1.038627e-08 7.984 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 1.435952e-08 7.843 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.452911e-08 7.838 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.468844e-08 7.833 0 0
Packaging Of Telomere Ends R-HSA-171306 1.559519e-08 7.807 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.687760e-08 7.773 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.687760e-08 7.773 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 2.057907e-08 7.687 0 0
Nucleosome assembly R-HSA-774815 2.057907e-08 7.687 0 0
Assembly of the pre-replicative complex R-HSA-68867 2.007206e-08 7.697 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.039733e-08 7.690 0 0
rRNA processing R-HSA-72312 2.386517e-08 7.622 0 0
Viral Infection Pathways R-HSA-9824446 2.944691e-08 7.531 0 0
HDACs deacetylate histones R-HSA-3214815 3.345381e-08 7.476 0 0
DNA Replication Pre-Initiation R-HSA-69002 3.808054e-08 7.419 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.973370e-08 7.401 0 0
Metabolism of RNA R-HSA-8953854 4.116285e-08 7.385 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 6.386825e-08 7.195 0 0
Mitotic Anaphase R-HSA-68882 6.922957e-08 7.160 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 7.946605e-08 7.100 0 0
Depurination R-HSA-73927 9.397134e-08 7.027 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 9.409809e-08 7.026 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 9.915598e-08 7.004 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.085140e-07 6.965 0 0
Signaling by RAS mutants R-HSA-6802949 1.170425e-07 6.932 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.170425e-07 6.932 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.170425e-07 6.932 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.170425e-07 6.932 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.269947e-07 6.896 0 0
Depyrimidination R-HSA-73928 1.269947e-07 6.896 0 0
Selenoamino acid metabolism R-HSA-2408522 1.264849e-07 6.898 0 0
Mitotic Prometaphase R-HSA-68877 1.493215e-07 6.826 0 0
Defective pyroptosis R-HSA-9710421 1.767017e-07 6.753 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.897713e-07 6.722 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.928004e-07 6.715 0 0
HSF1 activation R-HSA-3371511 1.978468e-07 6.704 0 0
Attenuation phase R-HSA-3371568 1.897713e-07 6.722 0 0
Gene Silencing by RNA R-HSA-211000 2.067459e-07 6.685 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.084792e-07 6.681 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.439987e-07 6.613 0 0
G2/M Checkpoints R-HSA-69481 2.742941e-07 6.562 0 0
Cleavage of the damaged purine R-HSA-110331 2.821229e-07 6.550 0 0
Separation of Sister Chromatids R-HSA-2467813 3.050526e-07 6.516 0 0
TCF dependent signaling in response to WNT R-HSA-201681 4.403468e-07 6.356 0 0
Adherens junctions interactions R-HSA-418990 4.461531e-07 6.351 0 0
G2/M DNA damage checkpoint R-HSA-69473 4.541178e-07 6.343 0 0
Signaling by ERBB2 R-HSA-1227986 4.992109e-07 6.302 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 4.999242e-07 6.301 0 0
Apoptosis R-HSA-109581 5.368608e-07 6.270 0 0
Meiosis R-HSA-1500620 5.742293e-07 6.241 0 0
Cell-cell junction organization R-HSA-421270 5.896339e-07 6.229 0 0
Base Excision Repair R-HSA-73884 6.937700e-07 6.159 0 0
DNA Replication R-HSA-69306 7.865102e-07 6.104 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 8.341686e-07 6.079 0 0
Meiotic synapsis R-HSA-1221632 9.233815e-07 6.035 0 0
Co-inhibition by PD-1 R-HSA-389948 8.738368e-07 6.059 0 0
DNA Double Strand Break Response R-HSA-5693606 8.739141e-07 6.059 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 9.134584e-07 6.039 0 0
Post NMDA receptor activation events R-HSA-438064 1.082524e-06 5.966 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.207998e-06 5.918 0 0
Ub-specific processing proteases R-HSA-5689880 1.292134e-06 5.889 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.437635e-06 5.842 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.689434e-06 5.772 0 0
RAF activation R-HSA-5673000 1.754851e-06 5.756 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.851104e-06 5.733 0 0
Deubiquitination R-HSA-5688426 1.908260e-06 5.719 0 0
ESR-mediated signaling R-HSA-8939211 2.111209e-06 5.675 0 0
Amyloid fiber formation R-HSA-977225 2.144084e-06 5.669 0 0
Homology Directed Repair R-HSA-5693538 2.161178e-06 5.665 0 0
MAPK family signaling cascades R-HSA-5683057 2.182530e-06 5.661 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.183660e-06 5.661 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 2.192355e-06 5.659 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.611707e-06 5.583 1 0
Cell-extracellular matrix interactions R-HSA-446353 2.629139e-06 5.580 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.630088e-06 5.580 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.922001e-06 5.534 0 0
RNA Polymerase I Transcription R-HSA-73864 3.349558e-06 5.475 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.315830e-06 5.479 1 0
Reproduction R-HSA-1474165 3.323704e-06 5.478 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 3.526337e-06 5.453 0 0
Chromosome Maintenance R-HSA-73886 3.526337e-06 5.453 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.917470e-06 5.407 0 0
Estrogen-dependent gene expression R-HSA-9018519 4.006941e-06 5.397 0 0
Translation initiation complex formation R-HSA-72649 4.082342e-06 5.389 0 0
HCMV Early Events R-HSA-9609690 5.271802e-06 5.278 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 5.418425e-06 5.266 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 5.418425e-06 5.266 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 5.423407e-06 5.266 0 0
Metalloprotease DUBs R-HSA-5689901 5.789273e-06 5.237 0 0
Processing of DNA double-strand break ends R-HSA-5693607 6.157052e-06 5.211 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 6.638938e-06 5.178 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 6.653924e-06 5.177 0 0
Programmed Cell Death R-HSA-5357801 8.240150e-06 5.084 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 9.478655e-06 5.023 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.004687e-05 4.998 0 0
Telomere Maintenance R-HSA-157579 1.038857e-05 4.983 0 0
Semaphorin interactions R-HSA-373755 1.059066e-05 4.975 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.061616e-05 4.974 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.097790e-05 4.959 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 1.228388e-05 4.911 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.413637e-05 4.850 0 0
G2/M Transition R-HSA-69275 1.469547e-05 4.833 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.570168e-05 4.804 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.802471e-05 4.744 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.705337e-05 4.768 0 0
Glycolysis R-HSA-70171 1.720334e-05 4.764 0 0
Signaling by VEGF R-HSA-194138 1.805370e-05 4.743 1 0
UCH proteinases R-HSA-5689603 1.818455e-05 4.740 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.855173e-05 4.732 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.053772e-05 4.687 0 0
Signaling by EGFR R-HSA-177929 2.087648e-05 4.680 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.336390e-05 4.631 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.378903e-05 4.624 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.387826e-05 4.622 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 2.647823e-05 4.577 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.721274e-05 4.565 0 0
Cytokine Signaling in Immune system R-HSA-1280215 2.873020e-05 4.542 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.008216e-05 4.522 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.614487e-05 4.442 0 0
RMTs methylate histone arginines R-HSA-3214858 4.028652e-05 4.395 0 0
Signaling by WNT R-HSA-195721 3.679008e-05 4.434 1 0
ISG15 antiviral mechanism R-HSA-1169408 4.125011e-05 4.385 0 0
Amplification of signal from the kinetochores R-HSA-141424 4.174739e-05 4.379 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 4.174739e-05 4.379 0 0
Mitotic Spindle Checkpoint R-HSA-69618 4.256286e-05 4.371 0 0
Interleukin-12 signaling R-HSA-9020591 4.950732e-05 4.305 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 5.371045e-05 4.270 1 0
RAF/MAP kinase cascade R-HSA-5673001 5.437934e-05 4.265 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 5.472681e-05 4.262 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 5.555817e-05 4.255 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 5.562262e-05 4.255 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 5.562262e-05 4.255 0 0
MAP2K and MAPK activation R-HSA-5674135 6.332724e-05 4.198 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 6.457681e-05 4.190 0 0
Chaperone Mediated Autophagy R-HSA-9613829 8.225504e-05 4.085 0 0
Ephrin signaling R-HSA-3928664 8.225504e-05 4.085 0 0
Recycling pathway of L1 R-HSA-437239 8.100161e-05 4.092 0 0
Activation of HOX genes during differentiation R-HSA-5619507 9.011041e-05 4.045 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 9.011041e-05 4.045 0 0
TCR signaling R-HSA-202403 9.156927e-05 4.038 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.207274e-05 4.036 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.207274e-05 4.036 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.207274e-05 4.036 0 0
Nuclear import of Rev protein R-HSA-180746 9.435322e-05 4.025 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.089880e-04 3.963 0 0
Signaling by NTRKs R-HSA-166520 1.091857e-04 3.962 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.198062e-04 3.922 0 0
L1CAM interactions R-HSA-373760 1.208778e-04 3.918 0 0
Aggrephagy R-HSA-9646399 1.268242e-04 3.897 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.312845e-04 3.882 0 0
Gene expression (Transcription) R-HSA-74160 1.376206e-04 3.861 1 0
Glucose metabolism R-HSA-70326 1.379259e-04 3.860 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.423626e-04 3.847 0 0
Interleukin-12 family signaling R-HSA-447115 1.451811e-04 3.838 0 0
EPH-Ephrin signaling R-HSA-2682334 1.505301e-04 3.822 0 0
Host Interactions of HIV factors R-HSA-162909 1.553048e-04 3.809 0 0
Selective autophagy R-HSA-9663891 1.693863e-04 3.771 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.696599e-04 3.770 0 0
Adaptive Immune System R-HSA-1280218 1.827753e-04 3.738 1 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.924462e-04 3.716 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.000933e-04 3.699 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.010974e-04 3.697 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.053104e-04 3.688 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.066009e-04 3.685 0 0
Regulation of CDH1 Function R-HSA-9764561 2.169569e-04 3.664 0 0
Generic Transcription Pathway R-HSA-212436 2.526194e-04 3.598 1 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.648735e-04 3.577 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 2.648735e-04 3.577 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.006415e-04 3.522 0 0
RNA Polymerase II Transcription R-HSA-73857 3.019329e-04 3.520 1 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.033941e-04 3.518 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.082665e-04 3.511 0 0
Signaling by ALK in cancer R-HSA-9700206 3.082665e-04 3.511 0 0
DNA Repair R-HSA-73894 3.124216e-04 3.505 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.428607e-04 3.465 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.507853e-04 3.455 0 0
HCMV Infection R-HSA-9609646 3.534205e-04 3.452 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.592153e-04 3.445 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.662350e-04 3.436 0 0
p75NTR signals via NF-kB R-HSA-193639 3.804313e-04 3.420 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.957748e-04 3.403 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.957748e-04 3.403 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.999783e-04 3.398 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 4.332303e-04 3.363 0 0
Signaling by NOTCH R-HSA-157118 4.782745e-04 3.320 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.789921e-04 3.320 0 0
FLT3 Signaling R-HSA-9607240 4.900030e-04 3.310 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.993612e-04 3.302 0 0
Hemostasis R-HSA-109582 5.141717e-04 3.289 1 0
p75NTR recruits signalling complexes R-HSA-209543 5.591577e-04 3.252 0 0
IRAK1 recruits IKK complex R-HSA-937039 5.591577e-04 3.252 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 5.591577e-04 3.252 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 5.591577e-04 3.252 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 6.027703e-04 3.220 0 0
Signaling by PTK6 R-HSA-8848021 6.240158e-04 3.205 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 6.240158e-04 3.205 0 0
HCMV Late Events R-HSA-9610379 5.769612e-04 3.239 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 6.258574e-04 3.204 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 6.336505e-04 3.198 0 0
Nephrin family interactions R-HSA-373753 6.778011e-04 3.169 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 7.369231e-04 3.133 0 0
Epigenetic regulation of gene expression R-HSA-212165 7.520350e-04 3.124 0 0
Immune System R-HSA-168256 7.645071e-04 3.117 1 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 7.743896e-04 3.111 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 7.958695e-04 3.099 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 7.986909e-04 3.098 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 9.136571e-04 3.039 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 9.516443e-04 3.022 0 0
Long-term potentiation R-HSA-9620244 9.830766e-04 3.007 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.006096e-03 2.997 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.006096e-03 2.997 0 0
G alpha (12/13) signalling events R-HSA-416482 1.045602e-03 2.981 0 0
MECP2 regulates transcription factors R-HSA-9022707 1.083001e-03 2.965 0 0
SOS-mediated signalling R-HSA-112412 1.083001e-03 2.965 0 0
Signaling by Interleukins R-HSA-449147 1.117687e-03 2.952 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.176736e-03 2.929 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.199977e-03 2.921 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.199977e-03 2.921 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.219072e-03 2.914 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.264144e-03 2.898 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.264144e-03 2.898 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.321650e-03 2.879 0 0
Muscle contraction R-HSA-397014 1.393102e-03 2.856 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.409642e-03 2.851 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.432560e-03 2.844 0 0
RET signaling R-HSA-8853659 1.505002e-03 2.822 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 1.601701e-03 2.795 0 0
Translation R-HSA-72766 1.602942e-03 2.795 0 0
DCC mediated attractive signaling R-HSA-418885 1.651722e-03 2.782 0 0
p38MAPK events R-HSA-171007 1.651722e-03 2.782 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.663979e-03 2.779 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.677641e-03 2.775 0 0
The NLRP3 inflammasome R-HSA-844456 1.904940e-03 2.720 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.945423e-03 2.711 0 0
Smooth Muscle Contraction R-HSA-445355 1.957395e-03 2.708 0 0
HIV Life Cycle R-HSA-162587 2.018978e-03 2.695 0 0
Platelet activation, signaling and aggregation R-HSA-76002 2.111874e-03 2.675 1 0
Interferon Signaling R-HSA-913531 2.219733e-03 2.654 0 0
Kinesins R-HSA-983189 2.355153e-03 2.628 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.011694e-03 2.696 0 0
Infectious disease R-HSA-5663205 1.977383e-03 2.704 0 0
SARS-CoV Infections R-HSA-9679506 2.141131e-03 2.669 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.367223e-03 2.626 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.384822e-03 2.623 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.384822e-03 2.623 0 0
Signaling by SCF-KIT R-HSA-1433557 2.430994e-03 2.614 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 2.430994e-03 2.614 0 0
Signaling by FGFR4 R-HSA-5654743 2.430994e-03 2.614 0 0
HIV Infection R-HSA-162906 2.556707e-03 2.592 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.557998e-03 2.592 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.557998e-03 2.592 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.557998e-03 2.592 0 0
Neurodegenerative Diseases R-HSA-8863678 2.557998e-03 2.592 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 2.564108e-03 2.591 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.621015e-03 2.582 0 0
Regulation of TP53 Activity R-HSA-5633007 2.624520e-03 2.581 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.673247e-03 2.573 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.673247e-03 2.573 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.759923e-03 2.559 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.901916e-03 2.537 0 0
PKR-mediated signaling R-HSA-9833482 3.039246e-03 2.517 0 0
Signaling by MET R-HSA-6806834 3.039246e-03 2.517 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 3.039246e-03 2.517 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.094573e-03 2.509 0 0
NRAGE signals death through JNK R-HSA-193648 3.108058e-03 2.508 0 0
Membrane Trafficking R-HSA-199991 3.129276e-03 2.505 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 3.137153e-03 2.503 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 3.197333e-03 2.495 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.217114e-03 2.493 0 0
Signalling to RAS R-HSA-167044 3.219320e-03 2.492 0 0
Signaling by FGFR3 R-HSA-5654741 3.403269e-03 2.468 0 0
Oncogene Induced Senescence R-HSA-2559585 3.506373e-03 2.455 0 0
Signalling to ERKs R-HSA-187687 3.506373e-03 2.455 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 3.611042e-03 2.442 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 3.611042e-03 2.442 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.659401e-03 2.437 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 3.787691e-03 2.422 0 0
Trafficking of AMPA receptors R-HSA-399719 3.787691e-03 2.422 1 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.844061e-03 2.415 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.844061e-03 2.415 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.844061e-03 2.415 0 0
Intracellular signaling by second messengers R-HSA-9006925 3.850791e-03 2.414 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.854340e-03 2.414 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.992669e-03 2.399 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.992669e-03 2.399 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 4.496220e-03 2.347 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 4.496220e-03 2.347 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 3.891875e-03 2.410 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 3.945524e-03 2.404 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 4.080022e-03 2.389 1 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 4.834007e-03 2.316 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 4.208452e-03 2.376 0 0
Regulation of TP53 Degradation R-HSA-6804757 4.208452e-03 2.376 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 3.945524e-03 2.404 0 0
Calmodulin induced events R-HSA-111933 4.208452e-03 2.376 0 0
CaM pathway R-HSA-111997 4.208452e-03 2.376 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 4.100964e-03 2.387 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 4.100964e-03 2.387 0 0
Specification of primordial germ cells R-HSA-9827857 3.992669e-03 2.399 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.996876e-03 2.398 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 5.018967e-03 2.299 0 0
MTF1 activates gene expression R-HSA-5660489 5.074982e-03 2.295 0 0
Signaling by KIT in disease R-HSA-9669938 5.160692e-03 2.287 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 5.160692e-03 2.287 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 5.171166e-03 2.286 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 5.245223e-03 2.280 0 0
Ca-dependent events R-HSA-111996 5.288886e-03 2.277 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 5.288886e-03 2.277 0 0
AURKA Activation by TPX2 R-HSA-8854518 5.374388e-03 2.270 0 0
NGF-stimulated transcription R-HSA-9031628 5.436330e-03 2.265 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 5.486096e-03 2.261 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 5.543529e-03 2.256 1 0
Activated NTRK3 signals through RAS R-HSA-9034864 5.606465e-03 2.251 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 5.689192e-03 2.245 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 5.856125e-03 2.232 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 5.856125e-03 2.232 0 0
Autophagy R-HSA-9612973 5.860377e-03 2.232 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 6.032116e-03 2.220 0 0
mRNA Splicing R-HSA-72172 6.167920e-03 2.210 0 0
MAP kinase activation R-HSA-450294 6.230644e-03 2.205 0 0
Gap junction trafficking and regulation R-HSA-157858 6.298167e-03 2.201 0 0
Erythropoietin activates RAS R-HSA-9027284 6.418859e-03 2.193 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 6.418859e-03 2.193 0 0
Spry regulation of FGF signaling R-HSA-1295596 6.418859e-03 2.193 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 6.421074e-03 2.192 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 6.530492e-03 2.185 1 0
Neutrophil degranulation R-HSA-6798695 6.591931e-03 2.181 0 0
Translesion Synthesis by POLH R-HSA-110320 6.605811e-03 2.180 0 0
Rap1 signalling R-HSA-392517 6.605811e-03 2.180 0 0
Regulation of signaling by CBL R-HSA-912631 6.605811e-03 2.180 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 6.633993e-03 2.178 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 7.011045e-03 2.154 0 0
Stabilization of p53 R-HSA-69541 7.011045e-03 2.154 0 0
Netrin-1 signaling R-HSA-373752 7.208430e-03 2.142 0 0
Ion homeostasis R-HSA-5578775 7.216666e-03 2.142 0 0
Signaling by FGFR1 R-HSA-5654736 7.216666e-03 2.142 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.265936e-03 2.139 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 7.307288e-03 2.136 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 7.307288e-03 2.136 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.318459e-03 2.136 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.318459e-03 2.136 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 7.491195e-03 2.125 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.660354e-03 2.116 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.660354e-03 2.116 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 7.727697e-03 2.112 0 0
NF-kB is activated and signals survival R-HSA-209560 7.727697e-03 2.112 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 7.727697e-03 2.112 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 8.613701e-03 2.065 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 8.765551e-03 2.057 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 8.318573e-03 2.080 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 7.905415e-03 2.102 0 0
mRNA 3'-end processing R-HSA-72187 9.554516e-03 2.020 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.034396e-02 1.985 0 0
Generation of second messenger molecules R-HSA-202433 8.216554e-03 2.085 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 9.578265e-03 2.019 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.911604e-03 2.004 0 0
Mitophagy R-HSA-5205647 7.885532e-03 2.103 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 9.313204e-03 2.031 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 9.578265e-03 2.019 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.355495e-03 2.078 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.355495e-03 2.078 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.361132e-03 2.078 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 8.036315e-03 2.095 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 9.307826e-03 2.031 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.034396e-02 1.985 0 0
Hedgehog 'off' state R-HSA-5610787 9.147597e-03 2.039 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 8.575100e-03 2.067 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 8.765551e-03 2.057 0 0
S Phase R-HSA-69242 9.307826e-03 2.031 0 0
Negative regulation of MET activity R-HSA-6807004 8.318573e-03 2.080 0 0
DAG and IP3 signaling R-HSA-1489509 8.355495e-03 2.078 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 9.637516e-03 2.016 1 1
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 8.355495e-03 2.078 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.084159e-03 2.042 0 0
Death Receptor Signaling R-HSA-73887 8.619732e-03 2.065 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 8.765551e-03 2.057 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 9.578265e-03 2.019 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.140589e-03 2.039 0 0
SARS-CoV-2 Infection R-HSA-9694516 8.375348e-03 2.077 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.037316e-02 1.984 0 0
EGFR downregulation R-HSA-182971 1.047289e-02 1.980 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.047289e-02 1.980 0 0
Downstream signal transduction R-HSA-186763 1.047289e-02 1.980 0 0
Metabolism of non-coding RNA R-HSA-194441 1.060278e-02 1.975 0 0
snRNP Assembly R-HSA-191859 1.060278e-02 1.975 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.070419e-02 1.970 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.085100e-02 1.965 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.088955e-02 1.963 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.088955e-02 1.963 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.088955e-02 1.963 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.088955e-02 1.963 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.088955e-02 1.963 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.088955e-02 1.963 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.088955e-02 1.963 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.088955e-02 1.963 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.088955e-02 1.963 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.088955e-02 1.963 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.088955e-02 1.963 0 0
Signaling by RAS GAP mutants R-HSA-9753510 1.088955e-02 1.963 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.088955e-02 1.963 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.089352e-02 1.963 0 0
FLT3 signaling in disease R-HSA-9682385 1.093236e-02 1.961 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.110893e-02 1.954 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 1.126894e-02 1.948 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.226842e-02 1.911 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 1.230486e-02 1.910 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 1.237248e-02 1.908 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.237248e-02 1.908 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.237248e-02 1.908 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.240125e-02 1.907 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 1.246753e-02 1.904 0 0
GPER1 signaling R-HSA-9634597 1.267280e-02 1.897 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 1.271339e-02 1.896 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.271339e-02 1.896 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.271339e-02 1.896 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.271339e-02 1.896 0 0
Signaling by FGFR2 R-HSA-5654738 1.290607e-02 1.889 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.294404e-02 1.888 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.311506e-02 1.882 0 0
Opioid Signalling R-HSA-111885 1.321429e-02 1.879 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.342934e-02 1.872 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.346761e-02 1.871 0 0
Maturation of protein E R-HSA-9694493 1.346761e-02 1.871 0 0
Maturation of protein E R-HSA-9683683 1.346761e-02 1.871 0 0
PLC beta mediated events R-HSA-112043 1.347947e-02 1.870 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.349068e-02 1.870 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.360451e-02 1.866 0 0
DNA Damage Bypass R-HSA-73893 1.444032e-02 1.840 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.444032e-02 1.840 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.458544e-02 1.836 0 0
Macroautophagy R-HSA-1632852 1.469018e-02 1.833 0 0
tRNA processing in the nucleus R-HSA-6784531 1.512820e-02 1.820 0 0
Centrosome maturation R-HSA-380287 1.516834e-02 1.819 0 0
Developmental Cell Lineages R-HSA-9734767 1.541234e-02 1.812 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.580190e-02 1.801 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.605381e-02 1.794 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.656050e-02 1.781 0 0
Inflammasomes R-HSA-622312 1.656050e-02 1.781 0 0
Polo-like kinase mediated events R-HSA-156711 1.676180e-02 1.776 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.676180e-02 1.776 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.676180e-02 1.776 1 1
EPHB-mediated forward signaling R-HSA-3928662 1.684429e-02 1.774 0 0
Gap junction trafficking R-HSA-190828 1.684429e-02 1.774 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.684429e-02 1.774 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.687078e-02 1.773 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.687078e-02 1.773 0 0
Josephin domain DUBs R-HSA-5689877 1.687078e-02 1.773 0 0
Pexophagy R-HSA-9664873 1.687078e-02 1.773 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.698211e-02 1.770 0 0
Striated Muscle Contraction R-HSA-390522 1.704440e-02 1.768 0 0
RAS processing R-HSA-9648002 1.709434e-02 1.767 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 1.723409e-02 1.764 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.784461e-02 1.748 0 0
Interleukin-17 signaling R-HSA-448424 1.784461e-02 1.748 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.853430e-02 1.732 1 1
Syndecan interactions R-HSA-3000170 1.860729e-02 1.730 0 0
Signaling by Erythropoietin R-HSA-9006335 1.952263e-02 1.709 0 0
Termination of translesion DNA synthesis R-HSA-5656169 1.952263e-02 1.709 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.957293e-02 1.708 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 1.963488e-02 1.707 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 1.963488e-02 1.707 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.977888e-02 1.704 0 0
Dual Incision in GG-NER R-HSA-5696400 1.979678e-02 1.703 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.055659e-02 1.687 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.055659e-02 1.687 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.184051e-02 1.661 0 0
Regulation of gap junction activity R-HSA-191650 3.120322e-02 1.506 0 0
Dopamine receptors R-HSA-390651 3.120322e-02 1.506 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 3.120322e-02 1.506 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 3.120322e-02 1.506 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.765054e-02 1.558 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.765054e-02 1.558 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.765054e-02 1.558 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 2.884173e-02 1.540 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.884173e-02 1.540 0 0
SHC1 events in EGFR signaling R-HSA-180336 2.205170e-02 1.657 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 2.205170e-02 1.657 0 0
Translesion synthesis by POLI R-HSA-5656121 2.736766e-02 1.563 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.491131e-02 1.604 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.985888e-02 1.525 0 0
HDMs demethylate histones R-HSA-3214842 2.623475e-02 1.581 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 2.656392e-02 1.576 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 2.999230e-02 1.523 0 0
G alpha (z) signalling events R-HSA-418597 2.926333e-02 1.534 1 1
Protein ubiquitination R-HSA-8852135 2.918631e-02 1.535 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.166414e-02 1.664 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.748334e-02 1.561 0 0
DAP12 signaling R-HSA-2424491 2.284998e-02 1.641 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 2.244405e-02 1.649 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.999230e-02 1.523 0 0
Integration of provirus R-HSA-162592 2.884173e-02 1.540 0 0
Protein folding R-HSA-391251 2.545630e-02 1.594 0 0
Translesion synthesis by REV1 R-HSA-110312 2.205170e-02 1.657 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 2.456644e-02 1.610 0 0
Signaling by TGFB family members R-HSA-9006936 2.170139e-02 1.664 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 3.098509e-02 1.509 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 3.098509e-02 1.509 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.491131e-02 1.604 0 0
Cellular response to chemical stress R-HSA-9711123 2.917009e-02 1.535 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.781119e-02 1.556 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 2.736766e-02 1.563 0 0
Degradation of CDH1 R-HSA-9766229 3.098509e-02 1.509 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 2.752443e-02 1.560 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 2.244405e-02 1.649 0 0
Activation of BH3-only proteins R-HSA-114452 2.284998e-02 1.641 0 0
G-protein mediated events R-HSA-112040 2.580902e-02 1.588 0 0
Regulation of PTEN localization R-HSA-8948747 2.765054e-02 1.558 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.752443e-02 1.560 0 0
Gluconeogenesis R-HSA-70263 2.764076e-02 1.558 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 2.884173e-02 1.540 0 0
Regulation of BACH1 activity R-HSA-9708530 2.736766e-02 1.563 0 0
Signaling by NOTCH4 R-HSA-9013694 2.657553e-02 1.576 0 0
Negative regulation of FLT3 R-HSA-9706369 2.736766e-02 1.563 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.518131e-02 1.599 0 0
Interleukin-1 signaling R-HSA-9020702 3.249622e-02 1.488 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.253610e-02 1.488 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.286825e-02 1.483 0 0
Circadian clock R-HSA-9909396 3.286825e-02 1.483 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 3.346785e-02 1.475 0 0
Translesion synthesis by POLK R-HSA-5655862 3.346785e-02 1.475 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 3.346785e-02 1.475 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.446051e-02 1.463 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.493337e-02 1.457 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 3.510519e-02 1.455 1 1
Integrin signaling R-HSA-354192 3.523033e-02 1.453 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.523033e-02 1.453 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 3.542835e-02 1.451 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.542835e-02 1.451 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.580362e-02 1.446 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 3.642909e-02 1.439 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 3.642909e-02 1.439 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 3.642909e-02 1.439 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 3.642909e-02 1.439 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 3.642909e-02 1.439 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 3.642909e-02 1.439 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 3.642909e-02 1.439 0 0
VLDLR internalisation and degradation R-HSA-8866427 3.642909e-02 1.439 0 0
Signaling by LTK R-HSA-9842663 3.642909e-02 1.439 0 0
GRB2 events in EGFR signaling R-HSA-179812 3.642909e-02 1.439 0 0
MET activates RAS signaling R-HSA-8851805 3.642909e-02 1.439 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 3.642909e-02 1.439 0 0
Ion transport by P-type ATPases R-HSA-936837 3.708905e-02 1.431 0 0
Type I hemidesmosome assembly R-HSA-446107 3.714671e-02 1.430 0 0
Formation of annular gap junctions R-HSA-196025 3.714671e-02 1.430 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.714671e-02 1.430 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.714671e-02 1.430 0 0
Adrenoceptors R-HSA-390696 3.714671e-02 1.430 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.714671e-02 1.430 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.714671e-02 1.430 0 0
Activation of RAS in B cells R-HSA-1169092 3.714671e-02 1.430 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 3.714671e-02 1.430 0 0
Modulation by Mtb of host immune system R-HSA-9637628 3.714671e-02 1.430 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 3.815651e-02 1.418 0 0
Nuclear Receptor transcription pathway R-HSA-383280 3.815651e-02 1.418 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 3.856798e-02 1.414 0 0
Signaling by Hippo R-HSA-2028269 4.038514e-02 1.394 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.101058e-02 1.387 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 4.101058e-02 1.387 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 4.129049e-02 1.384 0 0
IRE1alpha activates chaperones R-HSA-381070 4.141929e-02 1.383 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 4.164453e-02 1.380 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 4.164453e-02 1.380 0 0
Orc1 removal from chromatin R-HSA-68949 4.274675e-02 1.369 0 0
Signaling by FGFR R-HSA-190236 4.428532e-02 1.354 0 0
Switching of origins to a post-replicative state R-HSA-69052 4.504488e-02 1.346 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 4.513565e-02 1.345 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 4.513565e-02 1.345 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 4.513565e-02 1.345 0 0
Gap junction assembly R-HSA-190861 4.566321e-02 1.340 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 4.566321e-02 1.340 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 4.566321e-02 1.340 0 0
Defective Base Excision Repair Associated with OGG1 R-HSA-9656249 4.567276e-02 1.340 0 0
Oligomerization of connexins into connexons R-HSA-190704 4.567276e-02 1.340 0 0
Manipulation of host energy metabolism R-HSA-9636667 4.567276e-02 1.340 0 0
Transport of glycerol from adipocytes to the liver by Aquaporins R-HSA-432030 4.567276e-02 1.340 0 0
Transport of connexins along the secretory pathway R-HSA-190827 4.567276e-02 1.340 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.567276e-02 1.340 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 4.569163e-02 1.340 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 4.569163e-02 1.340 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 4.571611e-02 1.340 0 0
Late endosomal microautophagy R-HSA-9615710 4.748441e-02 1.323 0 0
DARPP-32 events R-HSA-180024 4.748441e-02 1.323 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 4.748441e-02 1.323 0 0
GAB1 signalosome R-HSA-180292 4.814456e-02 1.317 0 0
Tie2 Signaling R-HSA-210993 4.814456e-02 1.317 0 0
Regulation of PTEN gene transcription R-HSA-8943724 4.827273e-02 1.316 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 4.829453e-02 1.316 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 4.829453e-02 1.316 0 0
Gap junction degradation R-HSA-190873 4.829453e-02 1.316 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 4.829453e-02 1.316 0 0
Cellular response to mitochondrial stress R-HSA-9840373 4.829453e-02 1.316 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 4.869845e-02 1.312 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.882723e-02 1.311 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 5.077744e-02 1.294 0 0
Regulation of Apoptosis R-HSA-169911 5.157819e-02 1.288 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 5.326317e-02 1.274 0 0
Synthesis of DNA R-HSA-69239 5.382767e-02 1.269 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 5.415777e-02 1.266 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 5.485029e-02 1.261 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.498071e-02 1.260 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.498071e-02 1.260 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 5.498071e-02 1.260 0 0
Signaling by FGFR4 in disease R-HSA-5655291 5.498071e-02 1.260 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 5.676304e-02 1.246 0 0
Germ layer formation at gastrulation R-HSA-9754189 5.676304e-02 1.246 0 0
Signaling by NOTCH1 R-HSA-1980143 5.773802e-02 1.239 0 0
Triglyceride catabolism R-HSA-163560 5.797391e-02 1.237 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 5.851281e-02 1.233 0 0
Downstream TCR signaling R-HSA-202424 6.088068e-02 1.216 0 0
2-LTR circle formation R-HSA-164843 6.108718e-02 1.214 0 0
Regulation of CDH11 function R-HSA-9762292 6.108718e-02 1.214 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 6.108718e-02 1.214 0 0
Signaling by Leptin R-HSA-2586552 6.108718e-02 1.214 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 6.280746e-02 1.202 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 6.292751e-02 1.201 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.292751e-02 1.201 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 6.292751e-02 1.201 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.292751e-02 1.201 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 6.292751e-02 1.201 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 6.292751e-02 1.201 0 0
Ovarian tumor domain proteases R-HSA-5689896 6.485886e-02 1.188 0 0
Degradation of DVL R-HSA-4641258 6.485886e-02 1.188 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 6.596856e-02 1.181 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 6.596856e-02 1.181 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 6.596856e-02 1.181 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 6.596856e-02 1.181 0 0
Protein methylation R-HSA-8876725 6.596856e-02 1.181 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.596856e-02 1.181 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 6.596856e-02 1.181 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 6.596856e-02 1.181 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 6.614014e-02 1.180 0 0
Signal transduction by L1 R-HSA-445144 6.624936e-02 1.179 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 6.706965e-02 1.173 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 6.817243e-02 1.166 0 0
Regulation of mitotic cell cycle R-HSA-453276 6.817243e-02 1.166 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 6.817243e-02 1.166 0 0
IGF1R signaling cascade R-HSA-2428924 6.860829e-02 1.164 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.063148e-02 1.151 1 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 7.330817e-02 1.135 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 7.330817e-02 1.135 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 7.445458e-02 1.128 0 0
Ion channel transport R-HSA-983712 7.493689e-02 1.125 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 7.548767e-02 1.122 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 7.548767e-02 1.122 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 7.548767e-02 1.122 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 7.548767e-02 1.122 0 0
Signaling by APC mutants R-HSA-4839744 7.548767e-02 1.122 0 0
PECAM1 interactions R-HSA-210990 7.548767e-02 1.122 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 7.548767e-02 1.122 0 0
Regulation of TP53 Expression R-HSA-6804754 7.552027e-02 1.122 0 0
Diseases of Cellular Senescence R-HSA-9630747 7.552027e-02 1.122 0 0
Diseases of cellular response to stress R-HSA-9675132 7.552027e-02 1.122 0 0
Nucleotide Excision Repair R-HSA-5696398 7.617639e-02 1.118 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 7.660421e-02 1.116 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 7.661542e-02 1.116 0 0
Activation of ATR in response to replication stress R-HSA-176187 7.763044e-02 1.110 0 0
G-protein beta:gamma signalling R-HSA-397795 7.763044e-02 1.110 0 0
Regulation of necroptotic cell death R-HSA-5675482 7.763044e-02 1.110 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 7.817913e-02 1.107 0 0
Cilium Assembly R-HSA-5617833 7.846668e-02 1.105 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 8.103229e-02 1.091 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 8.134270e-02 1.090 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 8.167719e-02 1.088 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 8.167719e-02 1.088 0 0
Toll-like Receptor Cascades R-HSA-168898 8.210915e-02 1.086 0 0
PTEN Regulation R-HSA-6807070 8.213330e-02 1.085 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 8.271061e-02 1.082 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 8.271061e-02 1.082 0 0
Nef and signal transduction R-HSA-164944 8.271061e-02 1.082 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.296354e-02 1.081 0 0
Signaling by ERBB4 R-HSA-1236394 8.561976e-02 1.067 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.064842e-01 0.973 0 0
KIT mutants bind TKIs R-HSA-9669921 1.064842e-01 0.973 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.064842e-01 0.973 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.064842e-01 0.973 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.064842e-01 0.973 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.064842e-01 0.973 0 0
Defective OGG1 Substrate Binding R-HSA-9656255 1.064842e-01 0.973 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.064842e-01 0.973 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.064842e-01 0.973 0 0
Defective OGG1 Localization R-HSA-9657050 1.064842e-01 0.973 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.064842e-01 0.973 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.064842e-01 0.973 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.064842e-01 0.973 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.064842e-01 0.973 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.064842e-01 0.973 0 0
MET interacts with TNS proteins R-HSA-8875513 1.098332e-01 0.959 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.098332e-01 0.959 0 0
MET activates PTPN11 R-HSA-8865999 1.098332e-01 0.959 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.473231e-01 0.832 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.473231e-01 0.832 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.473231e-01 0.832 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 1.473231e-01 0.832 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 1.473231e-01 0.832 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 1.473231e-01 0.832 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.047938e-01 0.980 0 0
Netrin mediated repulsion signals R-HSA-418886 1.047938e-01 0.980 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.047938e-01 0.980 0 0
Disinhibition of SNARE formation R-HSA-114516 1.047938e-01 0.980 1 1
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 9.143295e-02 1.039 0 0
Activation of RAC1 R-HSA-428540 9.143295e-02 1.039 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.088382e-01 0.963 0 0
Disorders of Nervous System Development R-HSA-9697154 1.088382e-01 0.963 0 0
Pervasive developmental disorders R-HSA-9005895 1.088382e-01 0.963 0 0
Disorders of Developmental Biology R-HSA-9675151 9.131949e-02 1.039 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.131949e-02 1.039 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.276008e-01 0.894 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 8.782047e-02 1.056 0 0
Regulation of KIT signaling R-HSA-1433559 1.476046e-01 0.831 0 0
Removal of the Flap Intermediate R-HSA-69166 1.476046e-01 0.831 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 1.209564e-01 0.917 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 1.209564e-01 0.917 1 1
PKA activation in glucagon signalling R-HSA-164378 1.209564e-01 0.917 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.687236e-01 0.773 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 8.661951e-02 1.062 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 1.264569e-01 0.898 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.544750e-01 0.811 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 9.618952e-02 1.017 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.409049e-01 0.851 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.409049e-01 0.851 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 1.725272e-01 0.763 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.719277e-01 0.765 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 1.719277e-01 0.765 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.900851e-02 1.051 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.048349e-01 0.979 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.524367e-01 0.817 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.063346e-01 0.973 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 9.988352e-02 1.001 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 8.849803e-02 1.053 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 8.849803e-02 1.053 0 0
Formation of definitive endoderm R-HSA-9823730 1.544750e-01 0.811 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 1.490466e-01 0.827 0 0
Lagging Strand Synthesis R-HSA-69186 1.725272e-01 0.763 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.401132e-01 0.854 0 0
Processive synthesis on the lagging strand R-HSA-69183 1.687236e-01 0.773 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.547442e-01 0.810 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.687236e-01 0.773 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 1.691603e-01 0.772 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 1.348630e-01 0.870 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.501788e-01 0.823 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.476046e-01 0.831 0 0
Degradation of CRY and PER proteins R-HSA-9932298 1.067507e-01 0.972 0 0
Aquaporin-mediated transport R-HSA-445717 1.613762e-01 0.792 0 0
Synaptic adhesion-like molecules R-HSA-8849932 1.209564e-01 0.917 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 1.490466e-01 0.827 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 8.825701e-02 1.054 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 8.825701e-02 1.054 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 8.825701e-02 1.054 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 8.825701e-02 1.054 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 1.547442e-01 0.810 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.276008e-01 0.894 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 1.063346e-01 0.973 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 1.063346e-01 0.973 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.737667e-02 1.012 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.737667e-02 1.012 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 1.063346e-01 0.973 0 0
Antigen processing-Cross presentation R-HSA-1236975 1.389597e-01 0.857 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 9.131949e-02 1.039 0 0
ER-Phagosome pathway R-HSA-1236974 1.477461e-01 0.830 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 1.560765e-01 0.807 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 1.276008e-01 0.894 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 1.063346e-01 0.973 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.560765e-01 0.807 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.131949e-02 1.039 0 0
Leishmania infection R-HSA-9658195 1.272306e-01 0.895 0 0
Parasitic Infection Pathways R-HSA-9824443 1.272306e-01 0.895 0 0
Vesicle-mediated transport R-HSA-5653656 1.647338e-01 0.783 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 9.331310e-02 1.030 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.043475e-01 0.982 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 9.737667e-02 1.012 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 1.269588e-01 0.896 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 1.377738e-01 0.861 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 1.490466e-01 0.827 0 0
Regulated Necrosis R-HSA-5218859 1.557101e-01 0.808 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.559656e-01 0.807 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.043475e-01 0.982 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.549925e-01 0.810 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 1.031298e-01 0.987 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 1.607623e-01 0.794 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 1.607623e-01 0.794 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 8.825701e-02 1.054 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.473231e-01 0.832 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 1.473231e-01 0.832 0 0
Signaling by AXIN mutants R-HSA-4839735 9.143295e-02 1.039 0 0
Signaling by AMER1 mutants R-HSA-4839748 9.143295e-02 1.039 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.547442e-01 0.810 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 1.056240e-01 0.976 0 0
TGFBR3 expression R-HSA-9839394 1.409049e-01 0.851 0 0
Basigin interactions R-HSA-210991 1.725272e-01 0.763 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 1.170455e-01 0.932 0 0
Degradation of AXIN R-HSA-4641257 1.283101e-01 0.892 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.672806e-02 1.014 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 1.030667e-01 0.987 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.549925e-01 0.810 0 0
DAP12 interactions R-HSA-2172127 1.377738e-01 0.861 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.161442e-01 0.935 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.200915e-01 0.920 0 0
Co-stimulation by CD28 R-HSA-389356 1.061373e-01 0.974 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.043197e-01 0.982 1 0
Interleukin-1 family signaling R-HSA-446652 1.577357e-01 0.802 0 0
Signaling by Hedgehog R-HSA-5358351 1.150075e-01 0.939 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 1.088382e-01 0.963 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.661951e-02 1.062 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.547442e-01 0.810 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.476046e-01 0.831 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.048349e-01 0.979 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.047938e-01 0.980 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.047938e-01 0.980 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.687236e-01 0.773 0 0
Vpu mediated degradation of CD4 R-HSA-180534 8.661951e-02 1.062 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.719277e-01 0.765 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 1.560765e-01 0.807 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.700028e-01 0.770 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 1.047938e-01 0.980 0 0
PCP/CE pathway R-HSA-4086400 1.129211e-01 0.947 1 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.241939e-01 0.906 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.711042e-01 0.767 0 0
Platelet degranulation R-HSA-114608 8.775176e-02 1.057 0 0
Disease R-HSA-1643685 1.196295e-01 0.922 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.084067e-01 0.965 0 0
G1/S Transition R-HSA-69206 1.179624e-01 0.928 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.549925e-01 0.810 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 1.088382e-01 0.963 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 1.088382e-01 0.963 0 0
Formation of the anterior neural plate R-HSA-9823739 1.687236e-01 0.773 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 1.284111e-01 0.891 0 0
Viral Messenger RNA Synthesis R-HSA-168325 9.548753e-02 1.020 0 0
Potential therapeutics for SARS R-HSA-9679191 1.018633e-01 0.992 0 0
Glycogen metabolism R-HSA-8982491 8.849803e-02 1.053 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.687236e-01 0.773 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 9.387725e-02 1.027 0 0
Signaling by NOTCH2 R-HSA-1980145 9.618952e-02 1.017 0 0
Signaling by PDGF R-HSA-186797 1.720492e-01 0.764 0 0
Assembly Of The HIV Virion R-HSA-175474 8.782047e-02 1.056 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.133266e-01 0.946 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.719277e-01 0.765 0 0
MHC class II antigen presentation R-HSA-2132295 1.010515e-01 0.995 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.725272e-01 0.763 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.372613e-01 0.862 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.687236e-01 0.773 0 0
Interleukin-7 signaling R-HSA-1266695 1.409049e-01 0.851 0 0
Glycogen synthesis R-HSA-3322077 1.544750e-01 0.811 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.710901e-01 0.767 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.820293e-01 0.740 0 0
Binding and entry of HIV virion R-HSA-173107 1.820293e-01 0.740 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.820293e-01 0.740 0 0
Signal attenuation R-HSA-74749 1.820293e-01 0.740 0 0
Receptor Mediated Mitophagy R-HSA-8934903 1.820293e-01 0.740 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.820293e-01 0.740 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.830523e-01 0.737 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 1.838705e-01 0.735 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 1.838705e-01 0.735 0 0
NOD1/2 Signaling Pathway R-HSA-168638 1.838705e-01 0.735 0 0
Co-inhibition by BTLA R-HSA-9927353 1.869253e-01 0.728 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 1.869253e-01 0.728 0 0
IRS activation R-HSA-74713 1.869253e-01 0.728 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 1.869253e-01 0.728 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 1.869253e-01 0.728 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.869253e-01 0.728 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.869253e-01 0.728 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 1.869253e-01 0.728 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 1.869253e-01 0.728 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 1.869253e-01 0.728 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 1.869253e-01 0.728 0 0
NrCAM interactions R-HSA-447038 1.869253e-01 0.728 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.869253e-01 0.728 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 1.884105e-01 0.725 0 0
Sensory processing of sound R-HSA-9659379 1.888917e-01 0.724 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.905679e-01 0.720 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.908249e-01 0.719 0 0
Phosphorylation of the APC/C R-HSA-176412 1.908249e-01 0.719 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.908249e-01 0.719 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 1.908249e-01 0.719 1 1
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.908249e-01 0.719 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.913426e-01 0.718 0 0
Mitochondrial calcium ion transport R-HSA-8949215 1.913426e-01 0.718 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 1.913426e-01 0.718 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.923126e-01 0.716 0 0
Insulin receptor signalling cascade R-HSA-74751 1.943730e-01 0.711 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.947899e-01 0.710 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.978542e-01 0.704 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 2.016350e-01 0.695 0 0
Defective OGG1 Substrate Processing R-HSA-9656256 2.016350e-01 0.695 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.016350e-01 0.695 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.016350e-01 0.695 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.016350e-01 0.695 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.016350e-01 0.695 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.016350e-01 0.695 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 2.016350e-01 0.695 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 2.016350e-01 0.695 0 0
Hereditary fructose intolerance R-HSA-5657560 2.016350e-01 0.695 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.016350e-01 0.695 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.016350e-01 0.695 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.016350e-01 0.695 0 0
Inhibition of PKR R-HSA-169131 2.016350e-01 0.695 0 0
Stimuli-sensing channels R-HSA-2672351 2.025496e-01 0.693 0 0
IRS-mediated signalling R-HSA-112399 2.028043e-01 0.693 0 0
Cellular response to hypoxia R-HSA-1234174 2.059974e-01 0.686 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 2.064897e-01 0.685 0 0
MTOR signalling R-HSA-165159 2.064897e-01 0.685 0 0
Interleukin-2 signaling R-HSA-9020558 2.104695e-01 0.677 0 0
Dissolution of Fibrin Clot R-HSA-75205 2.104695e-01 0.677 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 2.108418e-01 0.676 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 2.108418e-01 0.676 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 2.108418e-01 0.676 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 2.137721e-01 0.670 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 2.137721e-01 0.670 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 2.137721e-01 0.670 0 0
Response to metal ions R-HSA-5660526 2.137721e-01 0.670 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.155760e-01 0.666 0 0
TBC/RABGAPs R-HSA-8854214 2.210630e-01 0.655 0 0
Response of Mtb to phagocytosis R-HSA-9637690 2.210630e-01 0.655 0 0
Activation of the pre-replicative complex R-HSA-68962 2.230641e-01 0.652 0 0
Hedgehog ligand biogenesis R-HSA-5358346 2.253444e-01 0.647 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 2.277654e-01 0.643 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.277654e-01 0.643 0 0
PKB-mediated events R-HSA-109703 2.277654e-01 0.643 0 0
PDE3B signalling R-HSA-165160 2.277654e-01 0.643 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.277654e-01 0.643 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 2.277654e-01 0.643 0 0
Diseases of Base Excision Repair R-HSA-9605308 2.277654e-01 0.643 0 0
Triglyceride metabolism R-HSA-8979227 2.282268e-01 0.642 0 0
Rab regulation of trafficking R-HSA-9007101 2.294872e-01 0.639 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.309429e-01 0.636 0 0
Growth hormone receptor signaling R-HSA-982772 2.309429e-01 0.636 0 0
Innate Immune System R-HSA-168249 2.337549e-01 0.631 0 0
Amine ligand-binding receptors R-HSA-375280 2.360023e-01 0.627 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 2.374277e-01 0.624 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.374277e-01 0.624 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 2.374277e-01 0.624 0 0
Glycogen storage diseases R-HSA-3229121 2.374277e-01 0.624 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 2.393120e-01 0.621 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 2.397891e-01 0.620 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.397891e-01 0.620 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 2.397891e-01 0.620 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 2.397891e-01 0.620 0 0
Budding and maturation of HIV virion R-HSA-162588 2.411255e-01 0.618 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 2.474021e-01 0.607 0 0
Fanconi Anemia Pathway R-HSA-6783310 2.512765e-01 0.600 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.512765e-01 0.600 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 2.515625e-01 0.599 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.515625e-01 0.599 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 2.515625e-01 0.599 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 2.517828e-01 0.599 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 2.547876e-01 0.594 0 0
DNA strand elongation R-HSA-69190 2.596010e-01 0.586 0 0
Signaling by WNT in cancer R-HSA-4791275 2.596010e-01 0.586 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.616557e-01 0.582 0 0
Apoptotic factor-mediated response R-HSA-111471 2.616557e-01 0.582 0 0
Mismatch Repair R-HSA-5358508 2.616557e-01 0.582 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.616557e-01 0.582 0 0
Platelet sensitization by LDL R-HSA-432142 2.616557e-01 0.582 0 0
Signaling by ALK R-HSA-201556 2.642585e-01 0.578 0 0
Signaling by TGFBR3 R-HSA-9839373 2.668533e-01 0.574 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.691312e-01 0.570 0 0
CREB phosphorylation R-HSA-199920 2.691312e-01 0.570 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.691312e-01 0.570 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 2.691312e-01 0.570 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 2.691312e-01 0.570 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.691312e-01 0.570 0 0
Repression of WNT target genes R-HSA-4641265 2.697283e-01 0.569 0 0
Polymerase switching R-HSA-69091 2.697283e-01 0.569 0 0
Leading Strand Synthesis R-HSA-69109 2.697283e-01 0.569 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.697283e-01 0.569 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.697283e-01 0.569 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 2.697283e-01 0.569 0 0
Regulation of IFNG signaling R-HSA-877312 2.697283e-01 0.569 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.697283e-01 0.569 0 0
Estrogen biosynthesis R-HSA-193144 2.697283e-01 0.569 0 0
Tight junction interactions R-HSA-420029 2.726169e-01 0.564 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 2.726169e-01 0.564 0 0
ABC-family proteins mediated transport R-HSA-382556 2.741934e-01 0.562 0 0
Nuclear RNA decay R-HSA-9930044 2.784329e-01 0.555 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 2.784329e-01 0.555 0 0
Hedgehog 'on' state R-HSA-5632684 2.812501e-01 0.551 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.814205e-01 0.551 0 0
Diseases of Immune System R-HSA-5260271 2.814205e-01 0.551 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 2.814205e-01 0.551 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.826998e-01 0.549 0 0
Signaling by NOTCH3 R-HSA-9012852 2.828802e-01 0.548 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 2.863230e-01 0.543 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 2.866582e-01 0.543 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 2.866582e-01 0.543 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 2.866582e-01 0.543 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.866582e-01 0.543 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 2.866582e-01 0.543 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 2.866582e-01 0.543 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 2.866582e-01 0.543 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 2.866582e-01 0.543 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.866582e-01 0.543 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 2.866582e-01 0.543 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 2.866582e-01 0.543 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 2.866582e-01 0.543 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 2.866582e-01 0.543 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.866582e-01 0.543 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 2.866582e-01 0.543 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 2.866582e-01 0.543 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 2.866582e-01 0.543 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 2.866582e-01 0.543 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 2.866582e-01 0.543 0 0
IKBKB deficiency causes SCID R-HSA-5602636 2.866582e-01 0.543 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 2.866582e-01 0.543 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.866582e-01 0.543 0 0
NTRK3 as a dependence receptor R-HSA-9603505 2.866582e-01 0.543 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 2.910655e-01 0.536 0 0
Intraflagellar transport R-HSA-5620924 2.987826e-01 0.525 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.987826e-01 0.525 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.000459e-01 0.523 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 3.000459e-01 0.523 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 3.000459e-01 0.523 0 0
Frs2-mediated activation R-HSA-170968 3.000459e-01 0.523 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 3.000459e-01 0.523 0 0
Interleukin-6 signaling R-HSA-1059683 3.000459e-01 0.523 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 3.104481e-01 0.508 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 3.104481e-01 0.508 0 0
Recycling of eIF2:GDP R-HSA-72731 3.104481e-01 0.508 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.104481e-01 0.508 0 0
CHL1 interactions R-HSA-447041 3.104481e-01 0.508 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.104481e-01 0.508 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 3.104481e-01 0.508 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 3.113011e-01 0.507 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 3.113011e-01 0.507 0 0
Protein hydroxylation R-HSA-9629569 3.113011e-01 0.507 0 0
Transmission across Chemical Synapses R-HSA-112315 3.124127e-01 0.505 1 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 3.130500e-01 0.504 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 3.156981e-01 0.501 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 3.156981e-01 0.501 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 3.156981e-01 0.501 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 3.156981e-01 0.501 0 0
Signaling by FGFR3 in disease R-HSA-5655332 3.156981e-01 0.501 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 3.164892e-01 0.500 0 0
Parasite infection R-HSA-9664407 3.200993e-01 0.495 0 0
Leishmania phagocytosis R-HSA-9664417 3.200993e-01 0.495 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 3.200993e-01 0.495 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.230860e-01 0.491 0 0
Inositol phosphate metabolism R-HSA-1483249 3.263779e-01 0.486 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 3.305213e-01 0.481 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 3.305213e-01 0.481 0 0
Malate-aspartate shuttle R-HSA-9856872 3.305213e-01 0.481 0 0
Signal regulatory protein family interactions R-HSA-391160 3.305213e-01 0.481 0 0
HDL assembly R-HSA-8963896 3.305213e-01 0.481 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 3.364676e-01 0.473 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 3.364676e-01 0.473 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 3.364676e-01 0.473 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 3.364676e-01 0.473 0 0
HIV elongation arrest and recovery R-HSA-167287 3.375634e-01 0.472 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.375634e-01 0.472 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 3.375634e-01 0.472 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 3.375634e-01 0.472 0 0
Extension of Telomeres R-HSA-180786 3.438667e-01 0.464 0 0
MITF-M-dependent gene expression R-HSA-9856651 3.449692e-01 0.462 0 0
Regulation of insulin secretion R-HSA-422356 3.472149e-01 0.459 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 3.481124e-01 0.458 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.512577e-01 0.454 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 3.512577e-01 0.454 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.512577e-01 0.454 1 1
Sodium/Proton exchangers R-HSA-425986 3.512577e-01 0.454 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.512577e-01 0.454 0 0
Platelet homeostasis R-HSA-418346 3.540139e-01 0.451 0 0
GPVI-mediated activation cascade R-HSA-114604 3.561742e-01 0.448 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 3.595414e-01 0.444 0 0
Platelet calcium homeostasis R-HSA-418360 3.595414e-01 0.444 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.595414e-01 0.444 0 0
Glucagon-type ligand receptors R-HSA-420092 3.595414e-01 0.444 0 0
G beta:gamma signalling through BTK R-HSA-8964315 3.609553e-01 0.443 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 3.609553e-01 0.443 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 3.617069e-01 0.442 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.626312e-01 0.441 0 0
Defective PAPSS2 causes SEMD-PA R-HSA-3560796 3.626312e-01 0.441 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.626312e-01 0.441 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 3.626312e-01 0.441 0 0
Potassium transport channels R-HSA-1296067 3.626312e-01 0.441 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 3.626312e-01 0.441 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 3.626312e-01 0.441 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 3.626312e-01 0.441 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.626312e-01 0.441 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.626312e-01 0.441 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.626312e-01 0.441 0 0
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization R-HSA-180897 3.626312e-01 0.441 0 0
DSCAM interactions R-HSA-376172 3.626312e-01 0.441 0 0
Integration of energy metabolism R-HSA-163685 3.653705e-01 0.437 0 0
G1 Phase R-HSA-69236 3.703124e-01 0.431 0 0
Cyclin D associated events in G1 R-HSA-69231 3.703124e-01 0.431 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 3.709700e-01 0.431 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 3.815587e-01 0.418 0 0
FGFR2 alternative splicing R-HSA-6803529 3.869112e-01 0.412 0 0
mTORC1-mediated signalling R-HSA-166208 3.869112e-01 0.412 0 0
Heme signaling R-HSA-9707616 3.908300e-01 0.408 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 3.911704e-01 0.408 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 3.911704e-01 0.408 0 0
Prolonged ERK activation events R-HSA-169893 3.911704e-01 0.408 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 3.911704e-01 0.408 0 0
Lipophagy R-HSA-9613354 3.911995e-01 0.408 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 3.911995e-01 0.408 0 0
ALK mutants bind TKIs R-HSA-9700645 3.911995e-01 0.408 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 3.911995e-01 0.408 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 3.911995e-01 0.408 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 3.911995e-01 0.408 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 3.911995e-01 0.408 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 3.911995e-01 0.408 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.911995e-01 0.408 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.911995e-01 0.408 0 0
Interleukin-1 processing R-HSA-448706 3.911995e-01 0.408 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 3.911995e-01 0.408 0 0
Cardiac conduction R-HSA-5576891 3.925753e-01 0.406 0 0
MET promotes cell motility R-HSA-8875878 3.957132e-01 0.403 0 0
Pyruvate metabolism R-HSA-70268 3.978070e-01 0.400 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 4.035861e-01 0.394 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 4.065239e-01 0.391 0 0
Regulation of pyruvate metabolism R-HSA-9861718 4.065239e-01 0.391 0 0
Diseases of DNA repair R-HSA-9675135 4.065239e-01 0.391 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 4.119806e-01 0.385 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 4.119806e-01 0.385 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 4.154659e-01 0.381 0 0
Plasma lipoprotein clearance R-HSA-8964043 4.154659e-01 0.381 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 4.154659e-01 0.381 0 0
Passive transport by Aquaporins R-HSA-432047 4.210104e-01 0.376 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 4.210104e-01 0.376 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 4.210104e-01 0.376 0 0
FCERI mediated MAPK activation R-HSA-2871796 4.254001e-01 0.371 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 4.254345e-01 0.371 0 0
Diseases of mitotic cell cycle R-HSA-9675126 4.254345e-01 0.371 0 0
Ca2+ pathway R-HSA-4086398 4.283857e-01 0.368 0 0
MAPK3 (ERK1) activation R-HSA-110056 4.299958e-01 0.367 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 4.299958e-01 0.367 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.299958e-01 0.367 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 4.299958e-01 0.367 0 0
PI3K/AKT activation R-HSA-198203 4.299958e-01 0.367 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.299958e-01 0.367 0 0
Axonal growth stimulation R-HSA-209563 4.305168e-01 0.366 0 0
Classical Kir channels R-HSA-1296053 4.305168e-01 0.366 0 0
Defective HPRT1 disrupts guanine and hypoxanthine salvage R-HSA-9734281 4.305168e-01 0.366 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.305168e-01 0.366 0 0
Invadopodia formation R-HSA-8941237 4.305168e-01 0.366 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.305168e-01 0.366 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 4.305168e-01 0.366 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.305168e-01 0.366 0 0
Intracellular oxygen transport R-HSA-8981607 4.305168e-01 0.366 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.305168e-01 0.366 0 0
Histamine receptors R-HSA-390650 4.305168e-01 0.366 0 0
FasL/ CD95L signaling R-HSA-75157 4.305168e-01 0.366 0 0
Deadenylation of mRNA R-HSA-429947 4.368236e-01 0.360 0 0
Interleukin-6 family signaling R-HSA-6783589 4.368236e-01 0.360 0 0
Cytoprotection by HMOX1 R-HSA-9707564 4.477287e-01 0.349 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 4.477287e-01 0.349 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 4.503395e-01 0.346 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 4.503395e-01 0.346 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 4.503395e-01 0.346 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 4.605620e-01 0.337 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 4.613574e-01 0.336 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 4.613574e-01 0.336 0 0
Dual incision in TC-NER R-HSA-6782135 4.653309e-01 0.332 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 4.664150e-01 0.331 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.674375e-01 0.330 0 0
Formation of the posterior neural plate R-HSA-9832991 4.674375e-01 0.330 0 0
Ionotropic activity of kainate receptors R-HSA-451306 4.674375e-01 0.330 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.674375e-01 0.330 0 0
Transport of RCbl within the body R-HSA-9758890 4.674375e-01 0.330 0 0
Suppression of apoptosis R-HSA-9635465 4.674375e-01 0.330 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.674375e-01 0.330 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 4.674375e-01 0.330 0 0
FOXO-mediated transcription R-HSA-9614085 4.680871e-01 0.330 0 0
Translation of Structural Proteins R-HSA-9683701 4.740930e-01 0.324 0 0
Protein-protein interactions at synapses R-HSA-6794362 4.758011e-01 0.323 0 0
Signaling by Insulin receptor R-HSA-74752 4.784875e-01 0.320 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 4.790417e-01 0.320 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 4.790417e-01 0.320 0 0
PKA activation R-HSA-163615 4.790417e-01 0.320 0 0
Presynaptic function of Kainate receptors R-HSA-500657 4.790417e-01 0.320 0 0
Interferon alpha/beta signaling R-HSA-909733 4.851256e-01 0.314 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 4.855075e-01 0.314 0 0
Myogenesis R-HSA-525793 4.855075e-01 0.314 0 0
Suppression of phagosomal maturation R-HSA-9637687 4.855075e-01 0.314 0 0
Adipogenesis R-HSA-9843745 4.887254e-01 0.311 0 0
Signal amplification R-HSA-392518 4.899283e-01 0.310 0 0
HCN channels R-HSA-1296061 4.911755e-01 0.309 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.911755e-01 0.309 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.911755e-01 0.309 0 0
Extrinsic Pathway of Fibrin Clot Formation R-HSA-140834 4.911755e-01 0.309 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 4.911755e-01 0.309 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.911755e-01 0.309 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.911755e-01 0.309 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.911755e-01 0.309 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.911755e-01 0.309 0 0
NADE modulates death signalling R-HSA-205025 4.911755e-01 0.309 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.911755e-01 0.309 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 4.911755e-01 0.309 0 0
ER to Golgi Anterograde Transport R-HSA-199977 4.918703e-01 0.308 0 0
ABC transporter disorders R-HSA-5619084 5.020135e-01 0.299 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.033732e-01 0.298 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.033732e-01 0.298 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 5.033732e-01 0.298 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 5.033732e-01 0.298 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 5.070193e-01 0.295 0 0
Specification of the neural plate border R-HSA-9834899 5.070193e-01 0.295 0 0
Maturation of nucleoprotein R-HSA-9694631 5.070193e-01 0.295 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 5.092079e-01 0.293 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 5.092079e-01 0.293 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 5.092079e-01 0.293 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 5.092079e-01 0.293 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 5.108594e-01 0.292 0 0
Neurexins and neuroligins R-HSA-6794361 5.134407e-01 0.290 0 0
G alpha (q) signalling events R-HSA-416476 5.223577e-01 0.282 0 0
NCAM signaling for neurite out-growth R-HSA-375165 5.306002e-01 0.275 0 0
Pyroptosis R-HSA-5620971 5.324010e-01 0.274 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 5.341916e-01 0.272 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.376990e-01 0.269 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 5.376990e-01 0.269 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 5.376990e-01 0.269 0 0
OAS antiviral response R-HSA-8983711 5.376990e-01 0.269 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 5.437635e-01 0.265 0 0
Activation of AMPA receptors R-HSA-399710 5.453764e-01 0.263 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 5.453764e-01 0.263 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 5.453764e-01 0.263 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.453764e-01 0.263 0 0
Defective F9 activation R-HSA-9673221 5.453764e-01 0.263 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.453764e-01 0.263 0 0
PTK6 Down-Regulation R-HSA-8849472 5.453764e-01 0.263 0 0
Activation of AKT2 R-HSA-165158 5.453764e-01 0.263 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.453764e-01 0.263 0 0
Reelin signalling pathway R-HSA-8866376 5.453764e-01 0.263 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.453764e-01 0.263 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.453764e-01 0.263 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 5.550367e-01 0.256 0 0
G-protein activation R-HSA-202040 5.604938e-01 0.251 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 5.604938e-01 0.251 0 0
Regulation of TNFR1 signaling R-HSA-5357905 5.673287e-01 0.246 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 5.703501e-01 0.244 0 0
Processing of SMDT1 R-HSA-8949664 5.703501e-01 0.244 0 0
Formation of axial mesoderm R-HSA-9796292 5.703501e-01 0.244 0 0
Maturation of nucleoprotein R-HSA-9683610 5.703501e-01 0.244 0 0
CD28 dependent Vav1 pathway R-HSA-389359 5.703501e-01 0.244 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 5.703501e-01 0.244 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 5.713459e-01 0.243 0 0
Neuronal System R-HSA-112316 5.762386e-01 0.239 1 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 5.770727e-01 0.239 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 5.770727e-01 0.239 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 5.770727e-01 0.239 0 0
Interleukin-37 signaling R-HSA-9008059 5.770727e-01 0.239 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 5.777474e-01 0.238 0 0
TNF signaling R-HSA-75893 5.808015e-01 0.236 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 5.850134e-01 0.233 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 5.906249e-01 0.229 0 0
Plus-strand DNA synthesis R-HSA-164525 5.938065e-01 0.226 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.938065e-01 0.226 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 5.938065e-01 0.226 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.938065e-01 0.226 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.938065e-01 0.226 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 5.938065e-01 0.226 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.938065e-01 0.226 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 5.938065e-01 0.226 0 0
Pentose phosphate pathway disease R-HSA-6791465 5.938065e-01 0.226 0 0
Phosphorylation of Emi1 R-HSA-176417 5.938065e-01 0.226 0 0
Synthesis of PS R-HSA-1483101 5.938065e-01 0.226 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 5.938065e-01 0.226 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.938065e-01 0.226 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.938065e-01 0.226 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 5.938065e-01 0.226 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.938065e-01 0.226 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.938065e-01 0.226 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 5.938065e-01 0.226 0 0
TRAIL signaling R-HSA-75158 5.938065e-01 0.226 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 5.984737e-01 0.223 0 0
Molecules associated with elastic fibres R-HSA-2129379 5.984737e-01 0.223 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 6.012938e-01 0.221 0 0
Prolactin receptor signaling R-HSA-1170546 6.012938e-01 0.221 0 0
Zinc transporters R-HSA-435354 6.012938e-01 0.221 0 0
Metal ion SLC transporters R-HSA-425410 6.023188e-01 0.220 0 0
Gastrulation R-HSA-9758941 6.052134e-01 0.218 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 6.094160e-01 0.215 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 6.102985e-01 0.214 0 0
Notch-HLH transcription pathway R-HSA-350054 6.102985e-01 0.214 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.131473e-01 0.212 0 0
Translation of Structural Proteins R-HSA-9694635 6.172504e-01 0.210 0 0
Inwardly rectifying K+ channels R-HSA-1296065 6.192110e-01 0.208 0 0
GPCR downstream signalling R-HSA-388396 6.222352e-01 0.206 1 0
ERBB2 Regulates Cell Motility R-HSA-6785631 6.305233e-01 0.200 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 6.305233e-01 0.200 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.305233e-01 0.200 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 6.305233e-01 0.200 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 6.337372e-01 0.198 0 0
PI3K Cascade R-HSA-109704 6.357165e-01 0.197 0 0
Signaling by LTK in cancer R-HSA-9842640 6.370800e-01 0.196 0 0
STAT5 Activation R-HSA-9645135 6.370800e-01 0.196 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.370800e-01 0.196 0 0
Uncoating of the HIV Virion R-HSA-162585 6.370800e-01 0.196 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.370800e-01 0.196 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.370800e-01 0.196 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.370800e-01 0.196 0 0
Abacavir transmembrane transport R-HSA-2161517 6.370800e-01 0.196 0 0
HDL clearance R-HSA-8964011 6.370800e-01 0.196 0 0
Lipid particle organization R-HSA-8964572 6.370800e-01 0.196 0 0
Neurofascin interactions R-HSA-447043 6.370800e-01 0.196 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 6.392622e-01 0.194 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 6.392622e-01 0.194 0 0
Cardiogenesis R-HSA-9733709 6.392622e-01 0.194 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 6.392622e-01 0.194 0 0
RAB geranylgeranylation R-HSA-8873719 6.432943e-01 0.192 0 0
FCERI mediated NF-kB activation R-HSA-2871837 6.467811e-01 0.189 0 0
RSV-host interactions R-HSA-9833110 6.536626e-01 0.185 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 6.561755e-01 0.183 0 0
Thromboxane signalling through TP receptor R-HSA-428930 6.561755e-01 0.183 0 0
Plasma lipoprotein assembly R-HSA-8963898 6.561755e-01 0.183 0 0
Activation of SMO R-HSA-5635838 6.580526e-01 0.182 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 6.580526e-01 0.182 0 0
Atorvastatin ADME R-HSA-9754706 6.580526e-01 0.182 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.583768e-01 0.182 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 6.586108e-01 0.181 0 0
Resolution of D-Loop Structures R-HSA-5693537 6.586108e-01 0.181 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 6.626647e-01 0.179 0 0
Leishmania parasite growth and survival R-HSA-9664433 6.662930e-01 0.176 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 6.662930e-01 0.176 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 6.673975e-01 0.176 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.673975e-01 0.176 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 6.700902e-01 0.174 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.757456e-01 0.170 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.757456e-01 0.170 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.757456e-01 0.170 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 6.757456e-01 0.170 0 0
DAG1 core M1 glycosylations R-HSA-8932506 6.757456e-01 0.170 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 6.757456e-01 0.170 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.757456e-01 0.170 0 0
PTK6 Expression R-HSA-8849473 6.757456e-01 0.170 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.757456e-01 0.170 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.757456e-01 0.170 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 6.757456e-01 0.170 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.757456e-01 0.170 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.757456e-01 0.170 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 6.772452e-01 0.169 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 6.772452e-01 0.169 0 0
Calnexin/calreticulin cycle R-HSA-901042 6.772452e-01 0.169 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 6.772452e-01 0.169 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 6.776066e-01 0.169 0 0
G protein gated Potassium channels R-HSA-1296059 6.776066e-01 0.169 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 6.776066e-01 0.169 0 0
Acyl chain remodelling of PS R-HSA-1482801 6.776066e-01 0.169 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 6.825663e-01 0.166 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 6.839122e-01 0.165 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 6.839122e-01 0.165 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 6.839122e-01 0.165 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 6.839122e-01 0.165 0 0
Synthesis of PG R-HSA-1483148 6.839122e-01 0.165 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 6.863980e-01 0.163 0 0
PERK regulates gene expression R-HSA-381042 6.951590e-01 0.158 0 0
Proteasome assembly R-HSA-9907900 6.954255e-01 0.158 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 6.980317e-01 0.156 0 0
TRP channels R-HSA-3295583 6.980317e-01 0.156 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 7.032193e-01 0.153 0 0
Signaling by FGFR in disease R-HSA-1226099 7.032193e-01 0.153 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 7.081454e-01 0.150 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 7.081454e-01 0.150 0 0
Uptake and function of anthrax toxins R-HSA-5210891 7.081454e-01 0.150 0 0
Reverse Transcription of HIV RNA R-HSA-162589 7.102938e-01 0.149 0 0
Minus-strand DNA synthesis R-HSA-164516 7.102938e-01 0.149 0 0
DAG1 core M2 glycosylations R-HSA-8932504 7.102938e-01 0.149 0 0
phospho-PLA2 pathway R-HSA-111995 7.102938e-01 0.149 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.102938e-01 0.149 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.102938e-01 0.149 0 0
MET receptor recycling R-HSA-8875656 7.102938e-01 0.149 0 0
Fructose biosynthesis R-HSA-5652227 7.102938e-01 0.149 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.102938e-01 0.149 0 0
Interleukin-9 signaling R-HSA-8985947 7.102938e-01 0.149 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.102938e-01 0.149 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.102938e-01 0.149 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.102938e-01 0.149 0 0
Nucleotide salvage defects R-HSA-9734207 7.102938e-01 0.149 0 0
Alpha-defensins R-HSA-1462054 7.102938e-01 0.149 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 7.104042e-01 0.148 0 0
Somitogenesis R-HSA-9824272 7.109610e-01 0.148 0 0
Mitochondrial biogenesis R-HSA-1592230 7.120488e-01 0.147 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 7.123498e-01 0.147 0 0
G1/S-Specific Transcription R-HSA-69205 7.123498e-01 0.147 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.174586e-01 0.144 0 0
Cristae formation R-HSA-8949613 7.174586e-01 0.144 0 0
Maturation of hRSV A proteins R-HSA-9828806 7.174586e-01 0.144 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 7.259298e-01 0.139 0 0
G alpha (s) signalling events R-HSA-418555 7.281701e-01 0.138 0 0
Voltage gated Potassium channels R-HSA-1296072 7.288194e-01 0.137 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 7.308050e-01 0.136 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 7.308050e-01 0.136 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 7.308050e-01 0.136 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.359009e-01 0.133 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.411629e-01 0.130 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.411629e-01 0.130 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.411629e-01 0.130 0 0
Unwinding of DNA R-HSA-176974 7.411629e-01 0.130 0 0
Interleukin-21 signaling R-HSA-9020958 7.411629e-01 0.130 0 0
ARMS-mediated activation R-HSA-170984 7.411629e-01 0.130 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.411629e-01 0.130 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.411629e-01 0.130 0 0
Calcineurin activates NFAT R-HSA-2025928 7.411629e-01 0.130 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.411629e-01 0.130 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.411629e-01 0.130 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.411629e-01 0.130 0 0
Elastic fibre formation R-HSA-1566948 7.445730e-01 0.128 0 0
Transcription of the HIV genome R-HSA-167172 7.504451e-01 0.125 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 7.519513e-01 0.124 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 7.519513e-01 0.124 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 7.519513e-01 0.124 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 7.519513e-01 0.124 0 0
E2F mediated regulation of DNA replication R-HSA-113510 7.519513e-01 0.124 0 0
Regulation of gene expression in beta cells R-HSA-210745 7.533773e-01 0.123 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 7.596186e-01 0.119 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.614797e-01 0.118 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 7.638451e-01 0.117 0 0
Regulation of beta-cell development R-HSA-186712 7.638451e-01 0.117 0 0
Formation of apoptosome R-HSA-111458 7.687443e-01 0.114 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.687443e-01 0.114 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.687443e-01 0.114 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.687443e-01 0.114 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.687443e-01 0.114 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.687443e-01 0.114 0 0
Interleukin-27 signaling R-HSA-9020956 7.687443e-01 0.114 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.687443e-01 0.114 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 7.687443e-01 0.114 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.698369e-01 0.114 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 7.699103e-01 0.114 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 7.716494e-01 0.113 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.716494e-01 0.113 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 7.716494e-01 0.113 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 7.716494e-01 0.113 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 7.716494e-01 0.113 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 7.716494e-01 0.113 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 7.716494e-01 0.113 0 0
Signaling by NODAL R-HSA-1181150 7.716494e-01 0.113 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 7.739672e-01 0.111 0 0
HIV Transcription Elongation R-HSA-167169 7.739672e-01 0.111 0 0
Interleukin-2 family signaling R-HSA-451927 7.739672e-01 0.111 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 7.739672e-01 0.111 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 7.741621e-01 0.111 0 0
Interferon gamma signaling R-HSA-877300 7.756673e-01 0.110 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.789452e-01 0.108 0 0
Azathioprine ADME R-HSA-9748787 7.801776e-01 0.108 0 0
Signaling by FGFR2 in disease R-HSA-5655253 7.801776e-01 0.108 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.855260e-01 0.105 0 0
Formation of paraxial mesoderm R-HSA-9793380 7.872237e-01 0.104 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 7.876320e-01 0.104 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 7.899678e-01 0.102 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 7.899678e-01 0.102 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.899678e-01 0.102 0 0
DAG1 core M3 glycosylations R-HSA-8932505 7.933882e-01 0.101 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.933882e-01 0.101 0 0
LGI-ADAM interactions R-HSA-5682910 7.933882e-01 0.101 0 0
vRNA Synthesis R-HSA-192814 7.933882e-01 0.101 0 0
vRNP Assembly R-HSA-192905 7.933882e-01 0.101 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 7.933882e-01 0.101 0 0
Bicarbonate transporters R-HSA-425381 7.933882e-01 0.101 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.933882e-01 0.101 0 0
Vitamin B1 (thiamin) metabolism R-HSA-196819 7.933882e-01 0.101 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 7.945379e-01 0.100 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 7.982323e-01 0.098 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 7.991967e-01 0.097 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 7.996356e-01 0.097 0 0
Attachment and Entry R-HSA-9694614 8.069767e-01 0.093 0 0
Ribavirin ADME R-HSA-9755088 8.069767e-01 0.093 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 8.090276e-01 0.092 0 0
Neddylation R-HSA-8951664 8.135202e-01 0.090 0 0
FGFR1 mutant receptor activation R-HSA-1839124 8.141221e-01 0.089 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 8.151328e-01 0.089 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.154072e-01 0.089 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 8.154072e-01 0.089 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.154072e-01 0.089 0 0
ERKs are inactivated R-HSA-202670 8.154072e-01 0.089 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.154072e-01 0.089 0 0
Sodium/Calcium exchangers R-HSA-425561 8.154072e-01 0.089 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.175810e-01 0.087 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.227472e-01 0.085 0 0
Fructose metabolism R-HSA-5652084 8.227472e-01 0.085 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 8.227472e-01 0.085 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.258395e-01 0.083 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.271655e-01 0.082 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.271655e-01 0.082 0 0
Signaling by GPCR R-HSA-372790 8.331462e-01 0.079 1 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 8.350807e-01 0.078 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 8.350807e-01 0.078 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.350807e-01 0.078 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.350807e-01 0.078 0 0
Interleukin-35 Signalling R-HSA-8984722 8.350807e-01 0.078 0 0
Interleukin-15 signaling R-HSA-8983432 8.350807e-01 0.078 0 0
Interleukin receptor SHC signaling R-HSA-912526 8.373500e-01 0.077 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 8.373500e-01 0.077 0 0
Interleukin-20 family signaling R-HSA-8854691 8.373500e-01 0.077 0 0
Biosynthesis of maresins R-HSA-9018682 8.373500e-01 0.077 0 0
Carnitine shuttle R-HSA-200425 8.373500e-01 0.077 0 0
Disorders of transmembrane transporters R-HSA-5619115 8.474658e-01 0.072 0 0
Potassium Channels R-HSA-1296071 8.488897e-01 0.071 0 0
Complex III assembly R-HSA-9865881 8.508548e-01 0.070 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 8.526585e-01 0.069 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.526585e-01 0.069 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 8.526585e-01 0.069 0 0
Diseases of nucleotide metabolism R-HSA-9735804 8.526585e-01 0.069 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.526585e-01 0.069 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.526585e-01 0.069 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.562139e-01 0.067 0 0
RUNX2 regulates bone development R-HSA-8941326 8.616781e-01 0.065 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.633296e-01 0.064 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 8.633296e-01 0.064 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.633296e-01 0.064 0 0
Laminin interactions R-HSA-3000157 8.633296e-01 0.064 0 0
Hyaluronan degradation R-HSA-2160916 8.633296e-01 0.064 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.683637e-01 0.061 0 0
cGMP effects R-HSA-418457 8.683637e-01 0.061 0 0
Hydrolysis of LPC R-HSA-1483115 8.683637e-01 0.061 0 0
Biosynthesis of protectins R-HSA-9018681 8.683637e-01 0.061 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 8.683637e-01 0.061 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.683637e-01 0.061 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 8.683637e-01 0.061 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.683637e-01 0.061 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.683637e-01 0.061 0 0
COPII-mediated vesicle transport R-HSA-204005 8.710177e-01 0.060 0 0
Peroxisomal protein import R-HSA-9033241 8.715965e-01 0.060 0 0
MET activates PTK2 signaling R-HSA-8874081 8.748407e-01 0.058 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 8.748407e-01 0.058 0 0
Urea cycle R-HSA-70635 8.748407e-01 0.058 0 0
ECM proteoglycans R-HSA-3000178 8.783551e-01 0.056 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.794269e-01 0.056 0 0
Metabolism of polyamines R-HSA-351202 8.794269e-01 0.056 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.811810e-01 0.055 0 0
Signaling by Activin R-HSA-1502540 8.823957e-01 0.054 0 0
Transport and metabolism of PAPS R-HSA-174362 8.823957e-01 0.054 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.823957e-01 0.054 0 0
Other semaphorin interactions R-HSA-416700 8.823957e-01 0.054 0 0
Signaling by BMP R-HSA-201451 8.854516e-01 0.053 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 8.899828e-01 0.051 0 0
Pentose phosphate pathway R-HSA-71336 8.899828e-01 0.051 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 8.919791e-01 0.050 0 0
FCGR activation R-HSA-2029481 8.920878e-01 0.050 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.949327e-01 0.048 0 0
Phase 4 - resting membrane potential R-HSA-5576886 8.949327e-01 0.048 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 8.949327e-01 0.048 0 0
Activation of the phototransduction cascade R-HSA-2485179 8.949327e-01 0.048 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.949327e-01 0.048 0 0
Fructose catabolism R-HSA-70350 8.949327e-01 0.048 0 0
Differentiation of T cells R-HSA-9945266 8.949327e-01 0.048 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.949327e-01 0.048 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 8.949327e-01 0.048 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 8.949327e-01 0.048 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 8.949327e-01 0.048 0 0
Killing mechanisms R-HSA-9664420 8.949327e-01 0.048 0 0
Attachment and Entry R-HSA-9678110 8.949327e-01 0.048 0 0
Mitochondrial Uncoupling R-HSA-166187 8.949327e-01 0.048 0 0
Telomere Extension By Telomerase R-HSA-171319 8.952234e-01 0.048 0 0
Prednisone ADME R-HSA-9757110 8.952234e-01 0.048 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.952234e-01 0.048 0 0
The phototransduction cascade R-HSA-2514856 8.980238e-01 0.047 0 0
G alpha (i) signalling events R-HSA-418594 9.005600e-01 0.045 0 0
tRNA processing R-HSA-72306 9.008628e-01 0.045 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.042143e-01 0.044 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.049692e-01 0.043 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.057141e-01 0.043 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.061338e-01 0.043 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.061338e-01 0.043 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 9.061338e-01 0.043 0 0
Phase 2 - plateau phase R-HSA-5576893 9.061338e-01 0.043 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 9.061338e-01 0.043 0 0
Fibronectin matrix formation R-HSA-1566977 9.061338e-01 0.043 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 9.061338e-01 0.043 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 9.061338e-01 0.043 0 0
Galactose catabolism R-HSA-70370 9.061338e-01 0.043 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 9.061338e-01 0.043 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.061338e-01 0.043 0 0
Nucleotide biosynthesis R-HSA-8956320 9.114921e-01 0.040 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.124799e-01 0.040 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.129837e-01 0.040 0 0
Intra-Golgi traffic R-HSA-6811438 9.129837e-01 0.040 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.140389e-01 0.039 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.153561e-01 0.038 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.161414e-01 0.038 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.161414e-01 0.038 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 9.161414e-01 0.038 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.161414e-01 0.038 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.161414e-01 0.038 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.161414e-01 0.038 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 9.161414e-01 0.038 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.161414e-01 0.038 0 0
Activation of GABAB receptors R-HSA-991365 9.196201e-01 0.036 0 0
GABA B receptor activation R-HSA-977444 9.196201e-01 0.036 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.196201e-01 0.036 0 0
Cargo concentration in the ER R-HSA-5694530 9.200724e-01 0.036 0 0
Integrin cell surface interactions R-HSA-216083 9.204629e-01 0.036 0 0
SLC transporter disorders R-HSA-5619102 9.246272e-01 0.034 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.250826e-01 0.034 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.250826e-01 0.034 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.250826e-01 0.034 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.250826e-01 0.034 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.270414e-01 0.033 0 0
Metabolism of proteins R-HSA-392499 9.275884e-01 0.033 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 9.330709e-01 0.030 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.330709e-01 0.030 0 0
Diseases of hemostasis R-HSA-9671793 9.330709e-01 0.030 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.330709e-01 0.030 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.330709e-01 0.030 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.384745e-01 0.028 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.384745e-01 0.028 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.392926e-01 0.027 0 0
Heme degradation R-HSA-189483 9.392926e-01 0.027 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 9.402078e-01 0.027 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.402078e-01 0.027 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.402078e-01 0.027 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.402078e-01 0.027 0 0
Pregnenolone biosynthesis R-HSA-196108 9.402078e-01 0.027 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.428777e-01 0.026 0 0
eNOS activation R-HSA-203615 9.446595e-01 0.025 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.446595e-01 0.025 0 0
Hyaluronan metabolism R-HSA-2142845 9.446595e-01 0.025 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.446595e-01 0.025 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.463630e-01 0.024 0 0
Formation of the cornified envelope R-HSA-6809371 9.465099e-01 0.024 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.465841e-01 0.024 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 9.465841e-01 0.024 0 0
ERK/MAPK targets R-HSA-198753 9.465841e-01 0.024 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.465841e-01 0.024 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.465841e-01 0.024 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.465841e-01 0.024 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.465841e-01 0.024 0 0
Mitochondrial protein degradation R-HSA-9837999 9.467469e-01 0.024 0 0
Collagen formation R-HSA-1474290 9.467469e-01 0.024 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.489957e-01 0.023 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.495725e-01 0.022 0 0
Extracellular matrix organization R-HSA-1474244 9.514523e-01 0.022 0 0
Serine metabolism R-HSA-977347 9.522807e-01 0.021 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.540675e-01 0.020 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 9.540675e-01 0.020 0 0
RNA Polymerase III Transcription R-HSA-74158 9.540675e-01 0.020 0 0
Mitochondrial protein import R-HSA-1268020 9.544151e-01 0.020 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.545305e-01 0.020 0 0
Iron uptake and transport R-HSA-917937 9.559949e-01 0.020 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.573701e-01 0.019 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.573701e-01 0.019 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.573701e-01 0.019 0 0
LDL clearance R-HSA-8964038 9.573701e-01 0.019 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.573701e-01 0.019 0 0
Metabolism of folate and pterines R-HSA-196757 9.581776e-01 0.019 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.619170e-01 0.017 0 0
Formation of the ureteric bud R-HSA-9830674 9.619170e-01 0.017 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.619170e-01 0.017 0 0
Purine salvage R-HSA-74217 9.619338e-01 0.017 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.619338e-01 0.017 0 0
CYP2E1 reactions R-HSA-211999 9.659791e-01 0.015 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 9.659791e-01 0.015 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.659791e-01 0.015 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.660197e-01 0.015 0 0
Post-translational protein modification R-HSA-597592 9.672461e-01 0.014 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.684973e-01 0.014 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.684973e-01 0.014 0 0
Metabolism of steroid hormones R-HSA-196071 9.689785e-01 0.014 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.696082e-01 0.013 0 0
Formation of the nephric duct R-HSA-9830364 9.696082e-01 0.013 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.696082e-01 0.013 0 0
Protein localization R-HSA-9609507 9.698851e-01 0.013 0 0
PI Metabolism R-HSA-1483255 9.699922e-01 0.013 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.713126e-01 0.013 0 0
Maturation of spike protein R-HSA-9694548 9.713558e-01 0.013 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.718674e-01 0.012 0 0
Paracetamol ADME R-HSA-9753281 9.725825e-01 0.012 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.728504e-01 0.012 0 0
Abacavir ADME R-HSA-2161522 9.728504e-01 0.012 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 9.728504e-01 0.012 0 0
PPARA activates gene expression R-HSA-1989781 9.730001e-01 0.012 0 0
HIV Transcription Initiation R-HSA-167161 9.739632e-01 0.011 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.739632e-01 0.011 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.739632e-01 0.011 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.748341e-01 0.011 0 0
Triglyceride biosynthesis R-HSA-75109 9.757468e-01 0.011 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.757468e-01 0.011 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.757468e-01 0.011 0 0
Insulin processing R-HSA-264876 9.757468e-01 0.011 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.758217e-01 0.011 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.763405e-01 0.010 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.767836e-01 0.010 0 0
Dectin-2 family R-HSA-5621480 9.769092e-01 0.010 0 0
Synthesis of PA R-HSA-1483166 9.769092e-01 0.010 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 9.783344e-01 0.010 0 0
Formation of the Early Elongation Complex R-HSA-113418 9.783344e-01 0.010 0 0
Insulin receptor recycling R-HSA-77387 9.783344e-01 0.010 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.785071e-01 0.009 0 0
Surfactant metabolism R-HSA-5683826 9.804808e-01 0.009 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.804808e-01 0.009 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.804808e-01 0.009 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.805378e-01 0.009 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.806460e-01 0.008 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.806460e-01 0.008 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.817212e-01 0.008 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.817212e-01 0.008 0 0
GABA receptor activation R-HSA-977443 9.822008e-01 0.008 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.822782e-01 0.008 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.822782e-01 0.008 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.827112e-01 0.008 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.827112e-01 0.008 0 0
Neurotransmitter clearance R-HSA-112311 9.827112e-01 0.008 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.831294e-01 0.007 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.835830e-01 0.007 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.842777e-01 0.007 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.845561e-01 0.007 0 0
DAG1 glycosylations R-HSA-8931838 9.862042e-01 0.006 0 0
G0 and Early G1 R-HSA-1538133 9.862042e-01 0.006 0 0
HS-GAG degradation R-HSA-2024096 9.862042e-01 0.006 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.876765e-01 0.005 0 0
Recycling of bile acids and salts R-HSA-159418 9.876765e-01 0.005 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.876765e-01 0.005 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.889918e-01 0.005 0 0
Complex IV assembly R-HSA-9864848 9.901268e-01 0.004 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.901667e-01 0.004 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.901667e-01 0.004 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.918911e-01 0.004 0 0
HS-GAG biosynthesis R-HSA-2022928 9.921540e-01 0.003 0 0
Glycosphingolipid transport R-HSA-9845576 9.921540e-01 0.003 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.929916e-01 0.003 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.929916e-01 0.003 0 0
NCAM1 interactions R-HSA-419037 9.929916e-01 0.003 0 0
Collagen chain trimerization R-HSA-8948216 9.929916e-01 0.003 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.938890e-01 0.003 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.955385e-01 0.002 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.955922e-01 0.002 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.959546e-01 0.002 0 0
tRNA Aminoacylation R-HSA-379724 9.959546e-01 0.002 0 0
Glutathione conjugation R-HSA-156590 9.959546e-01 0.002 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.960150e-01 0.002 0 0
Nucleotide salvage R-HSA-8956321 9.963399e-01 0.002 0 0
Cholesterol biosynthesis R-HSA-191273 9.964702e-01 0.002 0 0
Defensins R-HSA-1461973 9.968207e-01 0.001 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.968207e-01 0.001 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.968816e-01 0.001 0 0
Methylation R-HSA-156581 9.971602e-01 0.001 0 0
Xenobiotics R-HSA-211981 9.972920e-01 0.001 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.972920e-01 0.001 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.973256e-01 0.001 0 0
Kidney development R-HSA-9830369 9.979993e-01 0.001 0 0
Antimicrobial peptides R-HSA-6803157 9.980368e-01 0.001 0 0
Peptide ligand-binding receptors R-HSA-375276 9.982065e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.985238e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.986665e-01 0.001 0 0
Retinoid metabolism and transport R-HSA-975634 9.986665e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.986665e-01 0.001 0 0
Metabolism of porphyrins R-HSA-189445 9.986665e-01 0.001 0 0
Aspirin ADME R-HSA-9749641 9.989122e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.989991e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.990177e-01 0.000 0 0
Glucuronidation R-HSA-156588 9.990825e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.993477e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.994787e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.994787e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.995208e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.995842e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.995842e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.997500e-01 0.000 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.997638e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.997890e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.997890e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.997890e-01 0.000 0 0
Classical antibody-mediated complement activation R-HSA-173623 9.997904e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.997998e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.998372e-01 0.000 0 0
Keratinization R-HSA-6805567 9.998473e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.998483e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.998497e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.999044e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999179e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999238e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999392e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999393e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.999457e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999460e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999490e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999681e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999735e-01 0.000 0 0
Creation of C4 and C2 activators R-HSA-166786 9.999767e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999789e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999790e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999825e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999847e-01 0.000 0 0
Neurotransmitter release cycle R-HSA-112310 9.999861e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.999910e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999928e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999957e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.999977e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999980e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999981e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999981e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999985e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999985e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.999986e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999989e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999989e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999991e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999994e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999995e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999998e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999998e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999999e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999999e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999999e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways