AURA

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A5A3E0	S1068	Sugiyama	POTEF A26C1B	SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
O00299	S211	Sugiyama	CLIC1 G6 NCC27	CKKYRGFTIPEAFRGVHRYLsNAyAREEFAstCPDDEEIEL
O00507	S647	Sugiyama	USP9Y DFFRY	SIRLYAGDHEDYDPQTVRLGsRYSHVQEVQERLNFLRFLLK
O00560	S131	PSP	SDCBP MDA9 SYCL	GIREVILCKDQDGKIGLRLKsIDNGIFVQLVQANSPASLVG
O00560	T200	PSP	SDCBP MDA9 SYCL	QAFGEKITMTIRDRPFERTItMHKDSTGHVGFIFKNGKITS
O00571	S594	Sugiyama	DDX3X DBX DDX3	MAyEHHyKGssRGRSKssRFsGGFGARDYRQssGAssssFs
O14556	T301	Sugiyama	GAPDHS GAPD2 GAPDH2 GAPDS HSD-35 HSD35	ASTGAAKAVTKVIPELKGKLtGMAFRVPTPDVSVVDLTCRL
O14579	S99	Sugiyama	COPE	PELQAVRMFADyLAHEsRRDsIVAELDREMsRSVDVTNTTF
O14617	S658	Sugiyama	AP3D1 PRO0039	DERPRAVFHEEEQRRPKHRPsEADEEELARRREARKQEQAN
O14777	S44	EPSD\|PSP	NDC80 HEC HEC1 KNTC2	VNKQGLYtPQTKEKPTFGKLsINKPtsERKVsLFGKRtsGH
O14777	S55	EPSD\|PSP	NDC80 HEC HEC1 KNTC2	KEKPTFGKLsINKPtsERKVsLFGKRtsGHGsRNsQLGIFs
O14777	S69	EPSD\|PSP	NDC80 HEC HEC1 KNTC2	tsERKVsLFGKRtsGHGsRNsQLGIFsssEKIKDPRPLNDK
O14965	S10	GPS6\|ELM\|EPSD\|PSP	AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	___________MDRSKENCIsGPVKAtAPVGGPKRVLVTQQ
O14965	S104	GPS6\|ELM\|EPSD\|PSP	AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	VPHPVsRPLNNTQKsKQPLPsAPENNPEEELASKQKNEESK
O14965	S226	GPS6\|ELM\|EPSD\|PSP	AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	VYLILEYAPLGTVYRELQKLsKFDEQRTATYITELANALSY
O14965	S266	GPS6\|ELM\|EPSD\|PSP	AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	YCHSKRVIHRDIKPENLLLGsAGELKIADFGWsVHAPssRR
O14965	S278	GPS6\|ELM\|EPSD\|PSP	AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	KPENLLLGsAGELKIADFGWsVHAPssRRttLCGTLDYLPP
O14965	S342	GPS6\|ELM\|EPSD\|PSP	AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	FLVGKPPFEANTYQETYKRIsRVEFTFPDFVTEGARDLISR
O14965	S391	GPS6\|ELM\|EPSD\|PSP	AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	RPMLREVLEHPWITANSSKPsNCQNKESASKQS________
O14965	S41	GPS6\|ELM\|EPSD\|PSP	AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	GPKRVLVTQQFPCQNPLPVNsGQAQRVLCPsNsSQRIPLQA
O14965	S67	GPS6\|ELM\|EPSD\|PSP	AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	VLCPsNsSQRIPLQAQKLVssHKPVQNQKQKQLQATsVPHP
O14965	S83	GPS6\|ELM\|EPSD\|PSP	AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	KLVssHKPVQNQKQKQLQATsVPHPVsRPLNNTQKsKQPLP
O14965	S98	GPS6\|ELM\|EPSD\|PSP	AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	QLQATsVPHPVsRPLNNTQKsKQPLPsAPENNPEEELASKQ
O14965	T16	GPS6\|ELM\|EPSD\|PSP	AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	_____MDRSKENCIsGPVKAtAPVGGPKRVLVTQQFPCQNP
O14965	T287	GPS6\|ELM\|EPSD\|PSP	AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	AGELKIADFGWsVHAPssRRttLCGTLDYLPPEMIEGRMHD
O14965	T288	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	GELKIADFGWsVHAPssRRttLCGTLDYLPPEMIEGRMHDE
O14965	Y148	EPSD\|PSP	AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	WALEDFEIGRPLGKGKFGNVyLAREKQSKFILALKVLFKAQ
O14980	S1031	Sugiyama	XPO1 CRM1	FKEHLRDFLVQIKEFAGEDtsDLFLEEREIALRQADEEKHK
O15143	T21	EPSD\|PSP	ARPC1B ARC41	MAYHSFLVEPISCHAWNKDRtQIAICPNNHEVHIyEKSGAK
O15212	T107	Sugiyama	PFDN6 HKE2 PFD6	IKRYESQLRDLERQsEQQREtLAQLQQEFQRAQAAKAGAPG
O15350	S235	EPSD\|PSP	TP73 P73	IRVEGNNLSQYVDDPVTGRQsVVVPYEPPQVGTEFTTILYN
O15357	S43	Sugiyama	INPPL1 SHIP2	HRDLSRAAAEELLARAGRDGsFLVRDSESVAGAFALCVLYQ
O15360	S165	SIGNOR\|EPSD\|PSP	FANCA FAA FACA FANCH	LSSLLEFAQYLLAHSMFSRLsFCQELWKIQSSLLLEAVWHL
O43264	S605	Sugiyama	ZW10	GTECFLAQMRAQKGELLERLsSARNFsNMDDEENYSAASKA
O43379	S32	SIGNOR\|PSP	WDR62 C19orf14	NDAGEKLPSVMAGVPARRGQssPPPAPPICLRRRtRLstAs
O43379	S33	SIGNOR\|PSP	WDR62 C19orf14	DAGEKLPSVMAGVPARRGQssPPPAPPICLRRRtRLstAsE
O43379	S49	EPSD\|PSP	WDR62 C19orf14	RGQssPPPAPPICLRRRtRLstAsEETVQNRVsLEKVLGIT
O43379	T50	EPSD\|PSP	WDR62 C19orf14	GQssPPPAPPICLRRRtRLstAsEETVQNRVsLEKVLGITA
O43521	S93	SIGNOR\|EPSD\|PSP	BCL2L11 BIM	FATRsPLFIFMRRSsLLSRsssGYFsFDTDRsPAPMSCDKS
O43521	S94	SIGNOR\|EPSD\|PSP	BCL2L11 BIM	ATRsPLFIFMRRSsLLSRsssGYFsFDTDRsPAPMSCDKST
O43521	S98	SIGNOR\|EPSD\|PSP	BCL2L11 BIM	PLFIFMRRSsLLSRsssGYFsFDTDRsPAPMSCDKSTQtPs
O43823	S124	Sugiyama	AKAP8 AKAP95	SKEGGRGGsGGGGEGIQDREssFRFQPFESYDSRPCLPEHN
O43847	S94	Sugiyama	NRDC NRD1	ENSRVARLGADEsEEEGRRGsLsNAGDPEIVKsPsDPKQYR
O43852	S125	Sugiyama	CALU	IyEDVERQWKGHDLNEDGLVsWEEyKNATYGYVLDDPDPDD
O43852	S261	Sugiyama	CALU	RDKNRDGKMDKEEtKDWILPsDyDHAEAEARHLVyEsDQNK
O43852	S44	Sugiyama	CALU	KKDRVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQL
O43852	Y106	Sugiyama	CALU	GFVtVDELKDWIKFAQKRWIyEDVERQWKGHDLNEDGLVsW
O60361	Y136	Sugiyama	NME2P1	SLRFKPEELVDYKSCAHDWVyE___________________
O60814	S39	Sugiyama	H2BC12 H2BFT HIRIP1 HIST1H2BK	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
O75369	S458	Sugiyama	FLNB FLN1L FLN3 TABP TAP	PKsPFVVQVGEACNPNACRAsGRGLQPKGVRIRETTDFKVD
O75496	T25	EPSD\|PSP	GMNN	MKQKQEEIKENIKNSSVPRRtLKMIQPSAsGSLVGRENELs
O75533	S322	Sugiyama	SF3B1 SAP155	DtPGHGsGWAEtPRtDRGGDsIGEtPtPGAsKRKsRWDEtP
O75533	T316	Sugiyama	SF3B1 SAP155	tPKtERDtPGHGsGWAEtPRtDRGGDsIGEtPtPGAsKRKs
O75792	S17	Sugiyama	RNASEH2A RNASEHI RNHIA	____MDLSELERDNTGRCRLssPVPAVCRKEPCVLGVDEAG
O75821	S28	Sugiyama	EIF3G EIF3S4	sKPsWADQVEEEGEDDKCVtsELLKGIPLAtGDtsPEPELL
O94776	S433	Sugiyama	MTA2 MTA1L1 PID	ATRGtTEPHSRGHLsRPEAQsLsPyttsANRAKLLAKNRQt
O94967	S422	Sugiyama	WDR47 KIAA0893	PANGAQNPGPAKQEKNELRDstEQFQEYYRQRLRYQQHLEQ
O95239	T799	SIGNOR\|PSP	KIF4A KIF4	AQLKEKKESGENPPPKLRRRtFsLtEVRGQVsEsEDsItKQ
O95831	S100	Sugiyama	AIFM1 AIF PDCD8	AGAYAYKTMKEDEKRyNERIsGLGLtPEQKQKKAALsAsEG
O95983	S24	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	MBD3	KRWECPALPQGWEREEVPRRsGLSAGHRDVFYYsPSGKKFR
O95983	S85	SIGNOR\|EPSD\|PSP	MBD3	RTGKMLMSKMNKSRQRVRYDssNQVKGKPDLNTALPVRQTA
O96028	S56	SIGNOR\|PSP	NSD2 KIAA1090 MMSET TRX5 WHSC1	PSCEVNRECSVFLSKAQLsssLQEGVMQKFNGHDALPFIPA
P00338	S161	Sugiyama	LDHA PIG19	DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00338	S167	Sugiyama	LDHA PIG19	AWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVHPLSCHG
P00352	T267	SIGNOR\|PSP	ALDH1A1 ALDC ALDH1 PUMB1	STEVGKLIKEAAGKSNLKRVtLELGGKSPCIVLADADLDNA
P00352	T442	SIGNOR\|PSP	ALDH1A1 ALDC ALDH1 PUMB1	NNTFYGLSAGVFTKDIDKAItISSALQAGTVWVNCYGVVSA
P00352	T493	SIGNOR\|PSP	ALDH1A1 ALDC ALDH1 PUMB1	GNGRELGEYGFHEYTEVKTVtVKISQKNS____________
P00491	S163	Sugiyama	PNP NP	GQNPLRGPNDERFGDRFPAMsDAyDRtMRQRALstWKQMGE
P00491	S176	Sugiyama	PNP NP	GDRFPAMsDAyDRtMRQRALstWKQMGEQRELQEGTYVMVA
P00558	S174	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	LSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKEL
P00558	S175	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	SKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKELN
P00558	S393	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	GGDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDA
P00558	S399	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	CCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDALsNI__
P00558	Y161	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	KAEPAKIEAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNL
P03372	S167	EPSD\|PSP	ESR1 ESR NR3A1	PAFYRPNsDNRRQGGRERLAsTNDKGSMAMESAKETRYCAV
P03372	S305	EPSD\|PSP	ESR1 ESR NR3A1	DMRAANLWPsPLMIKRSKKNsLALSLtADQMVSALLDAEPP
P04075	S17	Sugiyama	ALDOA ALDA	____MPyQyPALtPEQKKELsDIAHRIVAPGKGILAADEst
P04075	S176	Sugiyama	ALDOA ALDA	EHtPsALAIMENANVLARyAsICQQNGIVPIVEPEILPDGD
P04075	S336	Sugiyama	ALDOA ALDA	GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075	S36	Sugiyama	ALDOA ALDA	LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075	S46	Sugiyama	ALDOA ALDA	PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04083	S173	Sugiyama	ANXA1 ANX1 LPC1	NRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRsEDFG
P04083	S201	Sugiyama	ANXA1 ANX1 LPC1	LsLAKGDRsEDFGVNEDLADsDARALyEAGERRKGtDVNVF
P04406	S241	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406	T229	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	AstGAAKAVGKVIPELNGKLtGMAFRVPtANVsVVDLtCRL
P04637	S106	SIGNOR\|EPSD\|PSP	TP53 P53	APAPSWPLSSSVPSQKTYQGsYGFRLGFLHSGTAKSVTCTy
P04637	S215	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	TP53 P53	IRVEGNLRVEYLDDRNtFRHsVVVPyEPPEVGSDCTTIHYN
P04637	S315	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	TP53 P53	PHHELPPGStKRALPNNTsssPQPKKKPLDGEyFTLQIRGR
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04818	S120	Sugiyama	TYMS TS OK/SW-cl.29	ELSSKGVKIWDANGsRDFLDsLGFsTREEGDLGPVyGFQWR
P05783	S177	Sugiyama	KRT18 CYK18 PIG46	ARLAADDFRVKyETELAMRQsVENDIHGLRKVIDDTNItRL
P05783	S53	GPS6\|EPSD	KRT18 CYK18 PIG46	AsVyAGAGGsGsRIsVsRstsFRGGMGsGGLAtGIAGGLAG
P05783	S93	Sugiyama	KRT18 CYK18 PIG46	GMGGIQNEKETMQsLNDRLAsyLDRVRSLETENRRLESKIR
P05787	S258	Sugiyama	KRT8 CYK8	QISDTSVVLsMDNSRsLDMDsIIAEVKAQyEDIANRsRAEA
P05787	S280	Sugiyama	KRT8 CYK8	IAEVKAQyEDIANRsRAEAEsMyQIKyEELQsLAGKHGDDL
P05787	S330	Sugiyama	KRT8 CYK8	MNRNISRLQAEIEGLKGQRAsLEAAIADAEQRGELAIKDAN
P05787	S404	Sugiyama	KRT8 CYK8	LDIEIATYRKLLEGEESRLEsGMQNMsIHtKTTSGYAGGLS
P05787	S410	Sugiyama	KRT8 CYK8	TYRKLLEGEESRLEsGMQNMsIHtKTTSGYAGGLSSAYGGL
P06733	S353	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	NEKsCNCLLLKVNQIGsVTEsLQACKLAQANGWGVMVsHRs
P06733	S37	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	NPtVEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRY
P06733	S40	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	VEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGK
P06733	T205	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06733	T41	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	EVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKG
P06733	Y44	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P06737	S430	Sugiyama	PYGL	KHLDRIVALFPKDVDRLRRMsLIEEEGSKRINMAHLCIVGS
P06748	S125	PSP	NPM1 NPM	GsGPVHIsGQHLVAVEEDAEsEDEEEEDVKLLsIsGKRsAP
P07195	S162	SIGNOR\|PSP\|Sugiyama	LDHB	DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195	S168	Sugiyama	LDHB	TWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIHPSSCHG
P07195	S303	Sugiyama	LDHB	GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195	T302	Sugiyama	LDHB	YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07205	S393	Sugiyama	PGK2 PGKB	GGDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEA
P07205	S399	Sugiyama	PGK2 PGKB	CCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEALSNM__
P07205	Y161	Sugiyama	PGK2 PGKB	KAEPDKIEAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNL
P07237	S427	Sugiyama	P4HB ERBA2L PDI PDIA1 PO4DB	WDKLGEtyKDHENIVIAKMDstANEVEAVKVHsFPtLKFFP
P07355	S184	Sugiyama	ANXA2 ANX2 ANX2L4 CAL1H LPC2D	sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK
P07384	S474	Sugiyama	CAPN1 CANPL1 PIG30	GQPAVHLKRDFFLANAsRARsEQFINLREVSTRFRLPPGEY
P07737	S30	Sugiyama	PFN1	NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07737	S58	Sugiyama	PFN1	KtFVNITPAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsL
P07737	S72	Sugiyama	PFN1	VGKDRssFyVNGLtLGGQKCsVIRDsLLQDGEFsMDLRtKs
P07737	S77	Sugiyama	PFN1	ssFyVNGLtLGGQKCsVIRDsLLQDGEFsMDLRtKstGGAP
P07737	S85	Sugiyama	PFN1	tLGGQKCsVIRDsLLQDGEFsMDLRtKstGGAPTFNVtVtK
P07737	T65	Sugiyama	PFN1	PAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQDGEFs
P07737	Y60	Sugiyama	PFN1	FVNITPAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQ
P07814	S1473	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	CEDWIKKtTARDQDLEPGAPsMGAKSLCIPFKPLCELQPGA
P07814	S330	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	KHRKNPIEKNLQMWEEMKKGsQFGQsCCLRAKIDMSSNNGC
P07814	S739	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	TKVEATKNETSAPFKERPtPsLNNNCttsEDsLVLyNRVAV
P07864	S161	Sugiyama	LDHC LDH3 LDHX	DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07864	S167	Sugiyama	LDHC LDH3 LDHX	VWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVHPTSCHG
P07900	S169	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	TVITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGTKVILH
P07900	S460	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	QFSKNIKLGIHEDsQNRKKLsELLRyytsAsGDEMVsLKDY
P07900	S53	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P07900	S623	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	tyGWTANMERIMKAQALRDNstMGyMAAKKHLEINPDHsII
P07900	T317	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	WtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P07900	Y493	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	EMVsLKDYCTRMKENQKHIyyItGETKDQVANsAFVERLRK
P08195	S134	Sugiyama	SLC3A2 MDU1	ELNELEPEKQPMNAAsGAAMsLAGAEKNGLVKIKVAEDEAE
P08195	S513	Sugiyama	SLC3A2 MDU1	ESSFPDIPGAVSANMTVKGQsEDPGsLLsLFRRLsDQRsKE
P08195	S518	Sugiyama	SLC3A2 MDU1	DIPGAVSANMTVKGQsEDPGsLLsLFRRLsDQRsKERSLLH
P08195	S521	Sugiyama	SLC3A2 MDU1	GAVSANMTVKGQsEDPGsLLsLFRRLsDQRsKERSLLHGDF
P08195	S598	Sugiyama	SLC3A2 MDU1	LQASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEP
P08238	S164	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	VVITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGTKVILH
P08238	S452	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	AFSKNLKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEy
P08238	S468	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238	S470	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	RLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItGEs
P08238	S48	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08238	S482	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	sGDEMtsLsEyVsRMKEtQKsIyyItGEsKEQVANsAFVER
P08238	T309	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	WtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08238	T479	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	tsQsGDEMtsLsEyVsRMKEtQKsIyyItGEsKEQVANsAF
P08238	T616	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	yGWTANMERIMKAQALRDNstMGyMMAKKHLEINPDHPIVE
P08238	Y472	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	sELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItGEsKE
P08238	Y484	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	DEMtsLsEyVsRMKEtQKsIyyItGEsKEQVANsAFVERVR
P08238	Y485	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	EMtsLsEyVsRMKEtQKsIyyItGEsKEQVANsAFVERVRK
P08670	S72	GPS6	VIM	LyAssPGGVyAtRssAVRLRssVPGVRLLQDsVDFsLADAI
P08758	T10	Sugiyama	ANXA5 ANX5 ENX2 PP4	___________MAQVLRGtVtDFPGFDERADAEtLRKAMKG
P08865	S75	Sugiyama	RPSA LAMBR LAMR1	WEKLLLAARAIVAIENPADVsVIssRNtGQRAVLKFAAAtG
P08865	T82	Sugiyama	RPSA LAMBR LAMR1	ARAIVAIENPADVsVIssRNtGQRAVLKFAAAtGAtPIAGR
P09104	S37	Sugiyama	ENO2	NPtVEVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRY
P09104	S40	Sugiyama	ENO2	VEVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRYLGK
P09104	T41	Sugiyama	ENO2	EVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRYLGKG
P09104	Y44	Sugiyama	ENO2	LyTAKGLFRAAVPsGAstGIyEALELRDGDKQRYLGKGVLK
P09972	S17	Sugiyama	ALDOC ALDC	____MPHSYPALSAEQKKELsDIALRIVAPGKGILAADEsV
P09972	S176	Sugiyama	ALDOC ALDC	ERTPSALAILENANVLARyAsICQQNGIVPIVEPEILPDGD
P09972	S45	Sugiyama	ALDOC ALDC	APGKGILAADEsVGsMAKRLsQIGVENtEENRRLYRQVLFs
P0CG38	S1068	Sugiyama	POTEI	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39	S1031	Sugiyama	POTEJ	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG47	S57	Sugiyama	UBB	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0CG48	S57	Sugiyama	UBC	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0DPH7	S48	Sugiyama	TUBA3C TUBA2	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P0DPH7	S54	Sugiyama	TUBA3C TUBA2	GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
P10275	S293	EPSD\|PSP	AR DHTR NR3C4	LGVPPAVRPtPCAPLAECKGsLLDDSAGKstEDTAEYsPFK
P10275	T282	EPSD\|PSP	AR DHTR NR3C4	QLRGDCMyAPLLGVPPAVRPtPCAPLAECKGsLLDDSAGKs
P10809	S398	Sugiyama	HSPD1 HSP60	LDVttsEyEKEKLNERLAKLsDGVAVLKVGGtsDVEVNEKK
P10809	S453	Sugiyama	HSPD1 HSP60	EEGIVLGGGCALLRCIPALDsLtPANEDQKIGIEIIKRTLK
P10809	T422	Sugiyama	HSPD1 HSP60	AVLKVGGtsDVEVNEKKDRVtDALNAtRAAVEEGIVLGGGC
P11047	S335	Sugiyama	LAMC1 LAMB2	DCEKCLPFFNDRPWRRAtAEsASECLPCDCNGRsQECyFDP
P11047	S942	Sugiyama	LAMC1 LAMB2	GFYNLQSGQGCERCDCHALGstNGQCDIRTGQCECQPGITG
P11142	S40	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142	T163	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142	T226	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11233	S194	GPS6\|EPSD\|PSP	RALA RAL	EIRARKMEDsKEKNGKKKRKsLAKRIRERCCIL________
P11413	S106	Sugiyama	G6PD	PFFKATPEEKLKLEDFFARNsyVAGQyDDAAsyQRLNsHMN
P11586	S490	Sugiyama	MTHFD1 MTHFC MTHFD	QTDKALFNRLVPSVNGVRRFsDIQIRRLKRLGIEKTDPTTL
P11586	S870	Sugiyama	MTHFD1 MTHFC MTHFD	EVYTKQGFGNLPICMAKtHLsLsHNPEQKGVPTGFILPIRD
P12268	S416	Sugiyama	IMPDH2 IMPD2	APGEYFFSDGIRLKKyRGMGsLDAMDKHLssQNRyFsEADK
P12755	S326	SIGNOR\|EPSD\|PSP	SKI	DVKEKFDYGNKYKRRVPRVSsEPPASIRPKTDDTSsQsPAP
P12755	S383	SIGNOR\|EPSD\|PSP	SKI	SNKsLGCVHPRQRLsAFRPWsPAVSASEKELsPHLPALIRD
P13489	S208	Sugiyama	RNH1 PRI RNH	RVLCQGLKDSPCQLEALKLEsCGVTSDNCRDLCGIVAsKAS
P13489	S290	Sugiyama	RNH1 PRI RNH	AKGCGDLCRVLRAKESLKELsLAGNELGDEGARLLCETLLE
P13639	S23	Sugiyama	EEF2 EF2	NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639	S38	Sugiyama	EEF2 EF2	NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13639	S587	Sugiyama	EEF2 EF2	CIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKAR
P13639	S793	Sugiyama	EEF2 EF2	ESQVAGTPMFVVKAyLPVNEsFGFTADLRSNTGGQAFPQCV
P13639	Y579	Sugiyama	EEF2 EF2	KDLEEDHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKH
P13639	Y730	Sugiyama	EEF2 EF2	HADAIHRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQ
P13667	T380	Sugiyama	PDIA4 ERP70 ERP72	PEKFQSKYEPRSHMMDVQGstQDsAIKDFVLKyALPLVGHR
P13797	S339	Sugiyama	PLS3	PRIDINMsGFNETDDLKRAEsMLQQADKLGCRQFVTPADVV
P13929	S37	Sugiyama	ENO3	NPtVEVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRY
P13929	S40	Sugiyama	ENO3	VEVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRYLGK
P13929	T41	Sugiyama	ENO3	EVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRYLGKG
P13929	Y44	Sugiyama	ENO3	LHtAKGRFRAAVPsGAstGIyEALELRDGDKGRYLGKGVLK
P14314	S126	Sugiyama	PRKCSH G19P1	yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14314	S478	Sugiyama	PRKCSH G19P1	DKFSAMKyEQGtGCWQGPNRstTVRLLCGKEtMVtStTEPS
P14314	T469	Sugiyama	PRKCSH G19P1	WGsWIGPDHDKFSAMKyEQGtGCWQGPNRstTVRLLCGKEt
P14618	S202	Sugiyama	PKM OIP3 PK2 PK3 PKM2	SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs
P14618	S346	Sugiyama	PKM OIP3 PK2 PK3 PKM2	CAtQMLEsMIKKPRPTRAEGsDVANAVLDGADCIMLSGEtA
P14618	S97	Sugiyama	PKM OIP3 PK2 PK3 PKM2	sHGtHEyHAEtIKNVRtAtEsFAsDPILyRPVAVALDTKGP
P14618	T45	PSP	PKM OIP3 PK2 PK3 PKM2	TFLEHMCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMI
P14618	T95	Sugiyama	PKM OIP3 PK2 PK3 PKM2	NFsHGtHEyHAEtIKNVRtAtEsFAsDPILyRPVAVALDTK
P14625	S109	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P14625	S172	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	VGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSELI
P14625	S514	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK
P14625	S551	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	MKEKQDKIyFMAGsSRKEAEssPFVERLLKKGyEVIyLTEP
P14866	S543	Sugiyama	HNRNPL HNRPL P/OKcl.14	ELGVKRPSSVKVFSGKsERsssGLLEWEsKSDALETLGFLN
P14866	Y474	Sugiyama	HNRNPL HNRPL P/OKcl.14	SKQPAIMPGQSyGLEDGsCsyKDFSESRNNRFstPEQAAKN
P15531	S122	Sugiyama	NME1 NDPKA NM23	GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P16070	S71	Sugiyama	CD44 LHR MDU2 MDU3 MIC4	DLCKAFNSTLPTMAQMEKALsIGFEtCRyGFIEGHVVIPRI
P17066	S42	Sugiyama	HSPA6 HSP70B'	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17812	S573	Sugiyama	CTPS1 CTPS	HYLQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD__
P17987	S35	Sugiyama	TCP1 CCT1 CCTA	EtIRsQNVMAAAsIANIVKssLGPVGLDKMLVDDIGDVTIT
P17987	S544	Sugiyama	TCP1 CCT1 CCTA	ILRIDDLIKLHPESKDDKHGsyEDAVHsGALND________
P18615	S131	Sugiyama	NELFE RD RDBP	QRsIsADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGE
P18621	S5	Sugiyama	RPL17	________________MVRysLDPENPtKsCKSRGSNLRVH
P18858	S901	Sugiyama	LIG1	DKQPEQATTSAQVACLYRKQsQIQNQQGEDsGsDPEDTY__
P19174	S1233	Sugiyama	PLCG1 PLC1	PAKENGDLsPFsGtsLRERGsDASGQLFHGRAREGsFEsRy
P19338	S460	Sugiyama	NCL	ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P20618	S151	Sugiyama	PSMB1 PSC5	PYYVYNIIGGLDEEGKGAVysFDPVGsyQRDsFKAGGSASA
P20618	S162	Sugiyama	PSMB1 PSC5	DEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLLDNQVG
P22392	Y151	Sugiyama	NME2 NM23B	SLWFKPEELVDyKSCAHDWVyE___________________
P22626	S225	Sugiyama	HNRNPA2B1 HNRPA2B1	GNFGFGDsRGGGGNFGPGPGsNFRGGsDGyGsGRGFGDGyN
P23246	S283	Sugiyama	SFPQ PSF	GPGGRsEEKIsDsEGFKANLsLLRRPGEKTyTQRCRLFVGN
P23381	S378	Sugiyama	WARS1 IFI53 WARS WRS	sIFLtDtAKQIKTKVNKHAFsGGRDtIEEHRQFGGNCDVDV
P23381	T383	Sugiyama	WARS1 IFI53 WARS WRS	DtAKQIKTKVNKHAFsGGRDtIEEHRQFGGNCDVDVSFMYL
P23526	S183	Sugiyama	AHCY SAHH	NLyKMMANGILKVPAINVNDsVtKsKFDNLyGCRESLIDGI
P25205	T368	Sugiyama	MCM3	SVAKSQLLRYVLCTAPRAIPttGRGSsGVGLTAAVtTDQET
P25205	T369	Sugiyama	MCM3	VAKSQLLRYVLCTAPRAIPttGRGSsGVGLTAAVtTDQETG
P25490	S365	EPSD\|PSP	YY1 INO80S	LVHtGEKPFQCTFEGCGKRFsLDFNLRTHVRIHtGDRPyVC
P25786	S211	Sugiyama	PSMA1 HC2 NU PROS30 PSC2	GLRALRETLPAEQDLttKNVsIGIVGKDLEFTIyDDDDVsP
P25789	T10	Sugiyama	PSMA4 HC9 PSC9	___________MSRRyDsRttIFsPEGRLYQVEYAMEAIGH
P25963	S262	PSP	NFKBIA IKBA MAD3 NFKBI	DVNRVTYQGYSPYQLTWGRPsTRIQQQLGQLTLENLQMLPE
P25963	S32	GPS6\|PSP	NFKBIA IKBA MAD3 NFKBI	AMEGPRDGLKKERLLDDRHDsGLDsMKDEEyEQMVKELQEI
P25963	S36	GPS6	NFKBIA IKBA MAD3 NFKBI	PRDGLKKERLLDDRHDsGLDsMKDEEyEQMVKELQEIRLEP
P25963	S63	PSP	NFKBIA IKBA MAD3 NFKBI	EQMVKELQEIRLEPQEVPRGsEPWKQQLTEDGDSFLHLAII
P26038	S576	Sugiyama	MSN	YKtLRQIRQGNTKQRIDEFEsM___________________
P26232	S654	Sugiyama	CTNNA2 CAPR	EELEDDsDFEQEDYDVRsRtsVQtEDDQLIAGQsARAIMAQ
P26641	T287	Sugiyama	EEF1G EF1G PRO1608	EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P27348	S145	Sugiyama	YWHAQ	YFRyLAEVACGDDRKQtIDNsQGAyQEAFDIsKKEMQPTHP
P27348	T141	Sugiyama	YWHAQ	MKGDYFRyLAEVACGDDRKQtIDNsQGAyQEAFDIsKKEMQ
P27695	S129	Sugiyama	APEX1 APE APE1 APEX APX HAP1 REF1	QELPGLSHQYWSAPsDKEGysGVGLLsRQCPLKVsyGIGDE
P27708	S1859	Sugiyama	CAD	RGIPGLPDGRFHLPPRIHRAsDPGLPAEEPKEKSSRKVAEP
P27797	S52	Sugiyama	CALR CRTC	GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27797	S78	Sugiyama	CALR CRTC	GDEEKDKGLQTSQDARFyALsAsFEPFSNKGQTLVVQFTVK
P27797	S80	Sugiyama	CALR CRTC	EEKDKGLQTSQDARFyALsAsFEPFSNKGQTLVVQFTVKHE
P27816	S636	Sugiyama	MAP4	sAAPtFMIsPEtVTGtGKKCsLPAEEDsVLEKLGERKPCNs
P27824	S362	Sugiyama	CANX	WDEDMDGEWEAPQIANPRCEsAPGCGVWQRPVIDNPNyKGK
P28066	S179	Sugiyama	PSMA5	sGtFVQCDARAIGsAsEGAQssLQEVyHKSMTLKEAIKSSL
P29401	S190	Sugiyama	TKT	ASIYKLDNLVAILDINRLGQsDPAPLQHQMDIyQKRCEAFG
P29401	S332	Sugiyama	TKT	GDKIATRKAYGQALAKLGHAsDRIIALDGDtKNstFsEIFK
P29401	S473	Sugiyama	TKT	AtEKAVELAANTKGICFIRTsRPENAIIyNNNEDFQVGQAK
P29692	S60	Sugiyama	EEF1D EF1D	ENGAsVILRDIARARENIQKsLAGssGPGAssGtsGDHGEL
P29692	S64	Sugiyama	EEF1D EF1D	sVILRDIARARENIQKsLAGssGPGAssGtsGDHGELVVRI
P30041	S186	Sugiyama	PRDX6 AOP2 KIAA0106	SLQLTAEKRVAtPVDWKDGDsVMVLPtIPEEEAKKLFPKGV
P30048	S199	Sugiyama	PRDX3 AOP1	SGLALRGLFIIDPNGVIKHLsVNDLPVGRSVEETLRLVKAF
P30050	S138	Sugiyama	RPL12	HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30086	S52	Sugiyama	PEBP1 PBP PEBP	AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P30086	T51	Sugiyama	PEBP1 PBP PEBP	GAAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDP
P30101	S474	Sugiyama	PDIA3 ERP57 ERP60 GRP58	yFsPANKKLNPKKyEGGRELsDFIsyLQREAtNPPVIQEEK
P30305	S353	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	CDC25B CDC25HU2	LKRLERPQDRDTPVQNKRRRsVtPPEEQQEAEEPKARVLRs
P30520	S451	Sugiyama	ADSS2 ADSS	FIEDELQIPVKWIGVGKsREsMIQLF_______________
P30533	S135	Sugiyama	LRPAP1 A2MRAP	LNVILAKYGLDGKKDARQVtsNsLsGtQEDGLDDPRLEKLW
P30533	S137	Sugiyama	LRPAP1 A2MRAP	VILAKYGLDGKKDARQVtsNsLsGtQEDGLDDPRLEKLWHK
P30533	S242	Sugiyama	LRPAP1 A2MRAP	TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P30740	S72	Sugiyama	SERPINB1 ELANH2 MNEI PI2	AQLSKTFHFNTVEEVHSRFQsLNADINKRGASYILKLANRL
P31327	S759	Sugiyama	CPS1	AKIALGIPLPEIKNVVSGKTsACFEPSLDyMVtKIPRWDLD
P31327	S898	Sugiyama	CPS1	LYKMRDILNMEKTLKGLNsEsMtEEtLKRAKEIGFSDKQIS
P31327	T900	Sugiyama	CPS1	KMRDILNMEKTLKGLNsEsMtEEtLKRAKEIGFSDKQISKC
P31939	S338	Sugiyama	ATIC PURH OK/SW-cl.86	FVALSDVCDVPTAKIISREVsDGIIAPGyEEEALTILSKKK
P31943	S54	Sugiyama	HNRNPH1 HNRPH HNRPH1	CKIQNGAQGIRFIYTREGRPsGEAFVELEsEDEVKLALKKD
P31943	T152	Sugiyama	HNRNPH1 HNRPH HNRPH1	SGLEIVPNGITLPVDFQGRStGEAFVQFAsQEIAEKALKKH
P32119	S112	Sugiyama	PRDX2 NKEFB TDPX1	KEGGLGPLNIPLLADVTRRLsEDyGVLKTDEGIAYRGLFII
P33316	S120	Sugiyama	DUT	PsKRARPAEVGGMQLRFARLsEHAtAPTRGsARAAGYDLYS
P33316	S243	Sugiyama	DUT	ERIFyPEIEEVQALDDtERGsGGFGstGKN___________
P33993	S409	Sugiyama	MCM7 CDC47 MCM2	QLLsyIDRLAPRSQYTTGRGssGVGLTAAVLRDSVSGELTL
P33993	S410	Sugiyama	MCM7 CDC47 MCM2	LLsyIDRLAPRSQYTTGRGssGVGLTAAVLRDSVSGELTLE
P34897	T44	Sugiyama	SHMT2	IRAQHSNAAQTQTGEANRGWtGQEsLsDsDPEMWELLQREK
P34931	S42	Sugiyama	HSPA1L	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P35221	S655	Sugiyama	CTNNA1	PEELDDsDFEtEDFDVRsRtsVQtEDDQLIAGQsARAIMAQ
P35606	S162	Sugiyama	COPB2	THYVMQIVINPKDNNQFAsAsLDRtIKVWQLGsssPNFTLE
P35613	S246	Sugiyama	BSG UNQ6505/PRO21383	VKssEHINEGEtAMLVCKSEsVPPVTDWAWyKITDSEDKAL
P35613	S279	Sugiyama	BSG UNQ6505/PRO21383	TDSEDKALMNGSESRFFVsssQGRSELHIENLNMEADPGQy
P36871	S483	Sugiyama	PGM1	DKVYtVEKADNFEysDPVDGsIsRNQGLRLIFTDGSRIVFR
P37802	S145	Sugiyama	TAGLN2 KIAA0120 CDABP0035	VQRTLMNLGGLAVARDDGLFsGDPNWFPKKSKENPRNFsDN
P37802	S163	Sugiyama	TAGLN2 KIAA0120 CDABP0035	LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802	S185	Sugiyama	TAGLN2 KIAA0120 CDABP0035	NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P38398	S308	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	BRCA1 RNF53	SSLLLTKDRMNVEKAEFCNKsKQPGLARSQHNRWAGSKETC
P38606	S384	Sugiyama	ATP6V1A ATP6A1 ATP6V1A1 VPP2	RLAEMPADSGYPAyLGARLAsFYERAGRVKCLGNPEREGSV
P38646	S148	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	YDDPEVQKDIKNVPFKIVRAsNGDAWVEAHGKLYSPSQIGA
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40337	S72	EPSD\|PSP	VHL	EEMEAGRPRPVLRSVNsREPsQVIFCNRsPRVVLPVWLNFD
P40925	S153	Sugiyama	MDH1 MDHA	ANtNCLtAsKSAPSIPKENFsCLtRLDHNRAKAQIALKLGV
P41091	S107	Sugiyama	EIF2S3 EIF2G	KIYKLDDPSCPRPECyRSCGsstPDEFPtDIPGtKGNFKLV
P41208	S170	SIGNOR\|EPSD\|PSP	CETN2 CALT CEN2	DRDGDGEVsEQEFLRIMKKTsLY__________________
P42566	S368	Sugiyama	EPS15 AF1P	EKNNVEQDLKEKEDTIKQRtsEVQDLQDEVQRENTNLQKLQ
P42677	T74	Sugiyama	RPS27 MPS1	VLCVGCSTVLCQPTGGKARLtEGCsFRRKQH__________
P43121	S93	Sugiyama	MCAM MUC18	IFRVRQGQGQSEPGEYEQRLsLQDRGAtLALtQVtPQDERI
P43243	S188	Sugiyama	MATR3 KIAA0723	EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43243	S195	Sugiyama	MATR3 KIAA0723	RDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRsQEsGyyD
P45974	S783	Sugiyama	USP5 ISOT	IDDLDAEAAMDISEGRsAADsIsEsVPVGPKVRDGPGKYQL
P46060	S454	Sugiyama	RANGAP1 KIAA1835 SD	VstFLAFPsPEKLLRLGPKssVLIAQQTDTSDPEKVVSAFL
P46776	S68	Sugiyama	RPL27A	yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777	S224	Sugiyama	RPL5 MSTP030	VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46779	S115	Sugiyama	RPL28	HMIRKNKYRPDLRMAAIRRAsAILRSQKPVMVKRKRTRPTK
P46937	S397	EPSD\|PSP	YAP1 YAP65	MttNssDPFLNsGtyHsRDEstDsGLsMssysVPRtPDDFL
P47712	S178	Sugiyama	PLA2G4A CPLA2 PLA2G4	RQQRKEHIRESMKKLLGPKNsEGLHSARDVPVVAILGSGGG
P47712	S454	Sugiyama	PLA2G4A CPLA2 PLA2G4	ssDsDDEsHEPKGtENEDAGsDyQsDNQASWIHRMIMALVS
P47712	S727	Sugiyama	PLA2G4A CPLA2 PLA2G4	VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P47712	S729	Sugiyama	PLA2G4A CPLA2 PLA2G4	KEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKPKA
P47756	S192	Sugiyama	CAPZB	TVMLWLQTNKSGsGtMNLGGsLtRQMEKDEtVsDCsPHIAN
P48643	S51	Sugiyama	CCT5 CCTE KIAA0098	LEALKSHIMAAKAVANtMRtsLGPNGLDKMMVDKDGDVtVT
P48729	S218	GPS6	CSNK1A1	QSRRDDMESLGYVLMYFNRTsLPWQGLKAATKKQKYEKISE
P48741	S42	Sugiyama	HSPA7 HSP70B	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49327	S1997	Sugiyama	FASN FAS	DGLLENQTPEFFQDVCKPKYsGtLNLDRVTREACPELDYFV
P49327	S519	Sugiyama	FASN FAS	MGTQWRGMGLSLMRLDRFRDsILRsDEAVKPFGLKVSQLLL
P49450	S7	GPS6\|ELM\|EPSD\|PSP	CENPA	______________MGPRRRsRKPEAPRRRsPsPtPtPGPs
P49588	S188	Sugiyama	AARS1 AARS	PGNMKDNFWEMGDtGPCGPCsEIHyDRIGGRDAAHLVNQDD
P49588	S627	Sugiyama	AARS1 AARS	ATHILNFALRSVLGEADQKGsLVAPDRLRFDFTAKGAMSTQ
P49589	S305	Sugiyama	CARS1 CARS	KLVPEAVGDQKALQEGEGDLsIsADRLsEKRSPNDFALWKA
P49589	S307	Sugiyama	CARS1 CARS	VPEAVGDQKALQEGEGDLsIsADRLsEKRSPNDFALWKASK
P49589	S312	Sugiyama	CARS1 CARS	GDQKALQEGEGDLsIsADRLsEKRSPNDFALWKASKPGEPS
P49736	S220	EPSD\|PSP	MCM2 BM28 CCNL1 CDCL1 KIAA0030	KNFLRTHVDsHGHNVFKERIsDMCKENREsLVVNyEDLAAR
P49736	S229	Sugiyama	MCM2 BM28 CCNL1 CDCL1 KIAA0030	sHGHNVFKERIsDMCKENREsLVVNyEDLAAREHVLAYFLP
P49810	S19	EPSD\|PSP	PSEN2 AD4 PS2 PSNL2 STM2	__MLTFMAsDsEEEVCDERtsLMsAEsPtPRSCQEGRQGPE
P49841	S9	EPSD\|PSP	GSK3B	____________MSGRPRttsFAEsCKPVQQPsAFGsMKVS
P50213	S352	Sugiyama	IDH3A	FATIKDGKSLTKDLGGNAKCsDFTEEICRRVKDLD______
P50395	S396	Sugiyama	GDI2 RABGDIB	IEQKFVsISDLLVPKDLGtEsQIFIsRTyDAttHFEttCDD
P50395	S45	Sugiyama	GDI2 RABGDIB	VNGKKVLHMDRNPyyGGEsAsItPLEDLyKRFKIPGsPPEs
P50395	S65	Sugiyama	GDI2 RABGDIB	sItPLEDLyKRFKIPGsPPEsMGRGRDWNVDLIPKFLMANG
P50395	T425	Sugiyama	GDI2 RABGDIB	DAttHFEttCDDIKNIYKRMtGsEFDFEEMKRKKNDIYGED
P50416	S612	Sugiyama	CPT1A CPT1	SMTRLFREGRTETVRSCTTEsCDFVRAMVDPAQTVEQRLKL
P50897	T261	Sugiyama	PPT1 CLN1 PPT	SEWFGFYRsGQAKEtIPLQEtsLytQDRLGLKEMDNAGQLV
P50990	S373	Sugiyama	CCT8 C21orf112 CCTQ KIAA0002	SEVGDTQVVVFKHEKEDGAIstIVLRGstDNLMDDIERAVD
P50990	S380	Sugiyama	CCT8 C21orf112 CCTQ KIAA0002	VVVFKHEKEDGAIstIVLRGstDNLMDDIERAVDDGVNtFK
P50991	S51	Sugiyama	CCT4 CCTD SRB	AQIRFsNISAAKAVADAIRtsLGPKGMDKMIQDGKGDVtIt
P50991	T50	Sugiyama	CCT4 CCTD SRB	PAQIRFsNISAAKAVADAIRtsLGPKGMDKMIQDGKGDVtI
P51116	S601	Sugiyama	FXR2 FMR1L2	RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51991	S350	Sugiyama	HNRNPA3 HNRPA3	NDFGNYSGQQQSNYGPMKGGsFGGRssGsPyGGGyGsGGGs
P51991	S355	Sugiyama	HNRNPA3 HNRPA3	YSGQQQSNYGPMKGGsFGGRssGsPyGGGyGsGGGsGGyGs
P51991	S356	Sugiyama	HNRNPA3 HNRPA3	SGQQQSNYGPMKGGsFGGRssGsPyGGGyGsGGGsGGyGsR
P52597	S54	Sugiyama	HNRNPF HNRPF	CtIHDGAAGVHFIYTREGRQsGEAFVELGsEDDVKMALKKD
P52907	S123	Sugiyama	CAPZA1	KEAsDPQPEEADGGLKsWREsCDsALRAYVKDHYSNGFCTV
P53041	S403	Sugiyama	PPP5C PPP5	DLLWSDPQPQNGRSISKRGVsCQFGPDVTKAFLEENNLDyI
P53350	T210	GPS6\|SIGNOR\|EPSD\|PSP	PLK1 PLK	VKIGDFGLATKVEYDGERKKtLCGtPNyIAPEVLSKKGHSF
P53396	S455	Sugiyama	ACLY	ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53667	S307	SIGNOR\|PSP	LIMK1 LIMK	SARQKPVLRsCsIDRsPGAGsLGsPAsQRKDLGRSEsLRVV
P53667	T508	PSP	LIMK1 LIMK	EKTQPEGLRSLKKPDRKKRYtVVGNPyWMAPEMINGRSYDE
P53671	S283	EPSD\|PSP	LIMK2	PHALSTLDTKENLEGtLRRRsLRRsNsIsKsPGPssPKEPL
P53671	T494	EPSD\|PSP	LIMK2	RLIVEERKRAPMEKATTKKRtLRKNDRKKRYtVVGNPYWMA
P53671	T505	EPSD\|PSP	LIMK2	MEKATTKKRtLRKNDRKKRYtVVGNPYWMAPEMLNGKSYDE
P54577	S386	Sugiyama	YARS1 YARS	sRLDIRVGKIITVEKHPDADsLyVEKIDVGEAEPRTVVSGL
P54578	S431	Sugiyama	USP14 TGT	GSNNCGYYDLQAVLTHQGRSssSGHyVSWVKRKQDEWIKFD
P54652	S41	Sugiyama	HSPA2	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P54652	T229	Sugiyama	HSPA2	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P54750	S345	Sugiyama	PDE1A	EMVLSTDMSGHFQQIKNIRNsLQQPEGIDRAKTMSLILHAA
P55010	S10	Sugiyama	EIF5	___________MSVNVNRsVsDQFyRyKMPRLIAKVEGKGN
P55036	S358	Sugiyama	PSMD4 MCB1	VLENLPGVDPNNEAIRNAMGsLAsQATKDGKKDKKEEDKK_
P55036	T264	Sugiyama	PSMD4 MCB1	AEAGIATTGtEDsDDALLKMtIsQQEFGRTGLPDLSSMTEE
P55060	S342	Sugiyama	CSE1L CAS XPO2	ASVCERPHYKNLFEDQNtLtsICEKVIVPNMEFRAADEEAF
P55795	T152	Sugiyama	HNRNPH2 FTP3 HNRPH2	SGLEIVPNGMTLPVDFQGRStGEAFVQFAsQEIAEKALKKH
P56537	S6	Sugiyama	EIF6 EIF3A ITGB4BP OK/SW-cl.27	_______________MAVRAsFENNCEIGCFAKLTNTYCLV
P57053	S39	Sugiyama	H2BC12L H2BFS H2BS1	VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P57073	S327	SIGNOR\|PSP	SOX8	YFHAGASPVWAHKSAPSASAsPTETGPPRPHIKTEQPsPGH
P57721	S158	Sugiyama	PCBP3 PCBP3-OT1 PCBP3OT	AsQCGsLIGKGGSKIKEIREstGAQVQVAGDMLPNstERAV
P57721	S59	Sugiyama	PCBP3 PCBP3-OT1 PCBP3OT	EGGLNVTLTIRLLMHGKEVGsIIGKKGETVKKMREESGARI
P57721	S82	Sugiyama	PCBP3 PCBP3-OT1 PCBP3OT	GKKGETVKKMREESGARINIsEGNCPERIVTITGPTDAIFK
P57721	T159	Sugiyama	PCBP3 PCBP3-OT1 PCBP3OT	sQCGsLIGKGGSKIKEIREstGAQVQVAGDMLPNstERAVT
P57723	S31	Sugiyama	PCBP4	EPELSITLTLRMLMHGKEVGsIIGKKGETVKRIREQSSARI
P58876	S39	Sugiyama	H2BC5 H2BFB HIRIP2 HIST1H2BD	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P60709	S199	Sugiyama	ACTB	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709	S368	Sugiyama	ACTB	sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709	S52	Sugiyama	ACTB	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709	Y53	Sugiyama	ACTB	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61081	S175	Sugiyama	UBE2M UBC12	NNRRLFEQNVQRSMRGGyIGstyFERCLK____________
P61163	S331	Sugiyama	ACTR1A CTRN1	GDRLLSEVKKLAPKDVKIRIsAPQERLYSTWIGGSILASLD
P61221	Y594	Sugiyama	ABCE1 RLI RNASEL1 RNASELI RNS4I OK/SW-cl.40	RPRINKLNsIKDVEQKKsGNyFFLDD_______________
P61978	S379	PSP	HNRNPK HNRPK	MAYEPQGGSGYDYSYAGGRGsyGDLGGPIIttQVtIPKDLA
P61978	S75	Sugiyama	HNRNPK HNRPK	GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61978	S81	Sugiyama	HNRNPK HNRPK	GGKNIKALRtDyNAsVsVPDssGPERILsISADIETIGEIL
P62258	S148	Sugiyama	YWHAE	YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62263	S70	Sugiyama	RPS14 PRO2640	KETICRVTGGMKVKADRDEssPyAAMLAAQDVAQRCKELGI
P62269	Y95	Sugiyama	RPS18 D6S218E	RQYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLK
P62277	S12	Sugiyama	RPS13	_________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62701	T247	Sugiyama	RPS4X CCG2 RPS4 SCAR	VIGKGNKPWIsLPRGKGIRLtIAEERDKRLAAKQSSG____
P62714	S43	Sugiyama	PPP2CB	LNENQVRTLCEKAKEILTKEsNVQEVRCPVTVCGDVHGQFH
P62736	S54	Sugiyama	ACTA2 ACTSA ACTVS GIG46	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736	Y55	Sugiyama	ACTA2 ACTSA ACTVS GIG46	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62807	S39	Sugiyama	H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI	VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA
P62826	T32	Sugiyama	RAN ARA24 OK/SW-cl.81	KLVLVGDGGtGKttFVKRHLtGEFEKKyVATLGVEVHPLVF
P62906	S64	Sugiyama	RPL10A NEDD6	QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62917	S130	Sugiyama	RPL8	GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62937	T157	Sugiyama	PPIA CYPA	NIVEAMERFGsRNGKTSKKItIADCGQLE____________
P62942	T7	Sugiyama	FKBP1A FKBP1 FKBP12	______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P62979	S57	Sugiyama	RPS27A UBA80 UBCEP1	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGA
P62987	S57	Sugiyama	UBA52 UBCEP2	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGI
P63167	S14	Sugiyama	DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1	_______MCDRKAVIKNADMsEEMQQDsVECAtQALEKYNI
P63167	S21	Sugiyama	DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1	MCDRKAVIKNADMsEEMQQDsVECAtQALEKYNIEKDIAAH
P63261	S199	Sugiyama	ACTG1 ACTG	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261	S368	Sugiyama	ACTG1 ACTG	sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261	S52	Sugiyama	ACTG1 ACTG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261	Y53	Sugiyama	ACTG1 ACTG	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267	S53	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267	Y54	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P67775	S43	Sugiyama	PPP2CA	LSESQVKSLCEKAKEILTKEsNVQEVRCPVTVCGDVHGQFH
P68032	S54	Sugiyama	ACTC1 ACTC	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032	Y55	Sugiyama	ACTC1 ACTC	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68104	T432	Sugiyama	EEF1A1 EEF1A EF1A LENG7	VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133	S54	Sugiyama	ACTA1 ACTA	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133	Y55	Sugiyama	ACTA1 ACTA	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68363	S48	Sugiyama	TUBA1B	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P68363	S54	Sugiyama	TUBA1B	GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
P68431	S11	GPS6\|SIGNOR\|ELM\|EPSD	H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J	__________MARtKQtARKstGGKAPRKQLATKAARKsAP
P78417	S13	Sugiyama	GSTO1 GSTTLP28	________MSGESARsLGKGsAPPGPVPEGsIRIySMRFCP
Q00587	S350	Sugiyama	CDC42EP1 BORG5 CEP1 MSE55	HyPEMDARQERVEVLPQARAsWEsLDEEWRAPQAGsRtPVP
Q00610	S147	Sugiyama	CLTC CLH17 CLTCL2 KIAA0034	VYHWSMEGESQPVKMFDRHssLAGCQIINYRTDAKQKWLLL
Q00610	S576	Sugiyama	CLTC CLH17 CLTCL2 KIAA0034	YNLIQQCTAFLLDALKNNRPsEGPLQTRLLEMNLMHAPQVA
Q00610	S751	Sugiyama	CLTC CLH17 CLTCL2 KIAA0034	YIQAACKTGQIKEVERICREsNCyDPERVKNFLKEAKLTDQ
Q00610	Y754	Sugiyama	CLTC CLH17 CLTCL2 KIAA0034	AACKTGQIKEVERICREsNCyDPERVKNFLKEAKLTDQLPL
Q01105	S168	Sugiyama	SET	ENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQN
Q01105	T169	Sugiyama	SET	NKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQNK
Q02218	S871	Sugiyama	OGDH	RKPLIIFTPKSLLRHPEARssFDEMLPGTHFQRVIPEDGPA
Q02224	T422	GPS6	CENPE	VTSSSLTLQQELKAKRKRRVtWCLGKINKMKNSNYADQFNI
Q02790	S78	Sugiyama	FKBP4 FKBP52	TGWLLDGTKFDSSLDRKDKFsFDLGKGEVIKAWDIAIATMK
Q02818	S369	Sugiyama	NUCB1 NUC	RFEEELAAREAELNAKAQRLsQETEALGRsQGRLEAQKREL
Q04446	S75	Sugiyama	GBE1	ILKNIGENEGGIDKFSRGyEsFGVHRCADGGLYCKEWAPGA
Q04695	S32	Sugiyama	KRT17	SsIKGSSGLGGGsSRTsCRLsGGLGAGsCRLGSAGGLGSTL
Q04721	S359	Sugiyama	NOTCH2	IDDCAFASCTPGSTCIDRVAsFSCMCPEGKAGLLCHLDDAC
Q05639	T432	Sugiyama	EEF1A2 EEF1AL STN	VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q06210	S261	Sugiyama	GFPT1 GFAT GFPT	GsQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDA
Q06710	S209	PSP	PAX8	AQPGSDKRKMDDSDQDSCRLsIDsQSSSsGPRKHLRTDAFS
Q06710	T277	PSP	PAX8	GEQGLYPLPLLNSTLDDGKAtLtPSNtPLGRNLstHQTYPV
Q06830	S30	Sugiyama	PRDX1 PAGA PAGB TDPX2	HPAPNFKAtAVMPDGQFKDIsLsDyKGKYVVFFFYPLDFTF
Q07157	S1063	Sugiyama	TJP1 ZO1	LPYVEKQAsRDLEQPtyRyEsssytDQFsRNYEHRLRYEDR
Q07866	S524	Sugiyama	KLC1 KLC KNS2	QRVAEVLNDPENMEKRRsREsLNVDVVKYESGPDGGEEVSM
Q07866	Y391	Sugiyama	KLC1 KLC KNS2	TKLGPDDPNVAKTKNNLAsCyLKQGKFKQAETLYKEILTRA
Q08378	S739	Sugiyama	GOLGA3	HLDLMKQLTLTQEALQSREQsLDALQTHyDELQARLGELQG
Q09161	S22	Sugiyama	NCBP1 CBP80 NCBP	SRRRHsDENDGGQPHKRRKtsDANEtEDHLEsLICKVGEKS
Q12798	S170	GPS6	CETN1 CEN1 CETN	DRDGDGEVNEEEFLRIMKKTsLY__________________
Q12965	T939	Sugiyama	MYO1E MYO1C	SIGPGLPKNSRPTRRNttQNtGySsGtQNANyPVRAAPPPP
Q13085	S1762	Sugiyama	ACACA ACAC ACC1 ACCA	EDPYKGYRYLYLTPQDYKRVsALNsVHCEHVEDEGESRYKI
Q13098	S474	Sugiyama	GPS1 COPS1 CSN1	MLRAAVLRNQIHVKsPPREGsQGELtPANsQsRMstNM___
Q13158	S203	SIGNOR\|EPSD\|PSP	FADD MORT1 GIG3	ARDLQNRsGAMsPMsWNsDAsTSEAS_______________
Q13263	S138	Sugiyama	TRIM28 KAP1 RNF96 TIF1B	PVCKQQCFSKDIVENyFMRDsGsKAATDAQDANQCCTSCED
Q13283	S232	Sugiyama	G3BP1 G3BP	EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13347	S301	Sugiyama	EIF3I EIF3S2 TRIP1	VKGHFGPINSVAFHPDGKSYssGGEDGyVRIHYFDPQYFEF
Q13526	S16	SIGNOR\|EPSD\|PSP	PIN1	_____MADEEKLPPGWEKRMsRSSGRVyYFNHItNAsQWER
Q13563	S829	PSP	PKD2 TRPP1 TRPP2	LDDsEEDDDEDSGHSSRRRGsIssGVsYEEFQVLVRRVDRM
Q13761	T14	EPSD\|PSP	RUNX3 AML2 CBFA3 PEBP2A3	_______MRIPVDPSTSRRFtPPsPAFPCGGGGGKMGENSG
Q13761	T173	EPSD\|PSP	RUNX3 AML2 CBFA3 PEBP2A3	tItVFTNPTQVATYHRAIKVtVDGPREPRRHRQKLEDQTKP
Q13905	S371	Sugiyama	RAPGEF1 GRF2	CssIGKLsKsDEQLsSLDRDsGQCsRNTSCETLDHYDPDYE
Q14152	S1028	Sugiyama	EIF3A EIF3S10 KIAA0139	NWRHADDDRPPRRGLDEDRGsWRtADEDRGPRRGMDDDRGP
Q14152	S1188	Sugiyama	EIF3A EIF3S10 KIAA0139	PWRPLVKPGGWREKEKAREEsWGPPRESRPsEEREWDREKE
Q14152	S492	Sugiyama	EIF3A EIF3S10 KIAA0139	VDAARHCDLQVRIDHTSRTLsFGsDLNyAtREDAPIGPHLQ
Q14152	S584	Sugiyama	EIF3A EIF3S10 KIAA0139	EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14152	S988	Sugiyama	EIF3A EIF3S10 KIAA0139	PRRGPEEDRFsRRGADDDRPsWRNTDDDRPPRRIADEDRGN
Q14157	S852	Sugiyama	UBAP2L KIAA0144 NICE4	LDyysIPFPtPttPLtGRDGsLAsNPysGDLtKFGRGDASS
Q14194	T101	EPSD\|PSP	CRMP1 DPYSL1 ULIP3	QGMTAADDFFQGTRAALVGGttMIIDHVVPEPGSSLLTSFE
Q14194	T102	EPSD\|PSP	CRMP1 DPYSL1 ULIP3	GMTAADDFFQGTRAALVGGttMIIDHVVPEPGSSLLTSFEK
Q14203	S19	EPSD\|PSP	DCTN1	__MAQSKRHVYSRTPSGSRMsAEASARPLRVGsRVEVIGKG
Q14511	S296	GPS6\|SIGNOR\|EPSD\|PSP	NEDD9 CASL	HVKYNCDIPGAAEPVARRHQsLsPNHPPPQLGQSVGsQNDA
Q14566	S271	Sugiyama	MCM6	VPDVSKLSTPGARAEtNsRVsGVDGyEtEGIRGLRALGVRD
Q14568	S169	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	TVITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGTKVILH
Q14568	S53	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14669	S1054	Sugiyama	TRIP12 KIAA0045 ULF	TQsPKSSFLASLNPKTWGRLstQsNSNNIEPARTAGGSGLA
Q14671	S709	Sugiyama	PUM1 KIAA0099 PUMH1	LGGFGTAVANSNTGSGSRRDsLtGSsDLYKRTSSSLTPIGH
Q14677	S166	Sugiyama	CLINT1 ENTH EPN4 EPNR KIAA0171	REERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSKWDE
Q14677	S173	Sugiyama	CLINT1 ENTH EPN4 EPNR KIAA0171	KKNKDKyVGVssDsVGGFRysERYDPEPKSKWDEEWDKNKS
Q14697	S916	Sugiyama	GANAB G2AN KIAA0088	GAGKPAAVVLQTKGSPEsRLsFQHDPEtsVLVLRKPGINVA
Q14847	S146	Sugiyama	LASP1 MLN50	FEKSRMGPsGGEGMEPERRDsQDGssyRRPLEQQQPHHIPt
Q14863	S197	SIGNOR\|PSP	POU6F1 BRN5 MPOU TCFB1	GPAYSQSAICRFEKLDITPKsAQKLKPVLEKWLNEAELRNQ
Q14980	S1883	PSP	NUMA1 NMP22 NUMA	PDYGNsALLsLPGyRPttRssARRsQAGVSSGAPPGRNsFY
Q14980	S1887	EPSD\|PSP	NUMA1 NMP22 NUMA	NsALLsLPGyRPttRssARRsQAGVSSGAPPGRNsFYMGTC
Q14980	S1969	EPSD\|PSP	NUMA1 NMP22 NUMA	GTItDEEMKtGDPQETLRRAsMQPIQIAEGTGITTRQQRKR
Q14980	S1991	EPSD\|PSP	NUMA1 NMP22 NUMA	QPIQIAEGTGITTRQQRKRVsLEPHQGPGtPEsKKATSCFP
Q14980	S2047	EPSD\|PSP	NUMA1 NMP22 NUMA	TTEAQKKAAPASTKQADRRQsMAFsILNtPKKLGNsLLRRG
Q14980	S2087	EPSD\|PSP	NUMA1 NMP22 NUMA	GASKKALsKAsPNTRSGtRRsPRIATttAsAAtAAAIGAtP
Q14980	T1804	EPSD\|PSP	NUMA1 NMP22 NUMA	APLEssLDsLGDVFLDsGRKtRSARRRttQIINITMTKKLD
Q14980	T1811	EPSD\|PSP	NUMA1 NMP22 NUMA	DsLGDVFLDsGRKtRSARRRttQIINITMTKKLDVEEPDsA
Q14980	T1812	EPSD\|PSP	NUMA1 NMP22 NUMA	sLGDVFLDsGRKtRSARRRttQIINITMTKKLDVEEPDsAN
Q14980	T2084	EPSD\|PSP	NUMA1 NMP22 NUMA	LRRGASKKALsKAsPNTRSGtRRsPRIATttAsAAtAAAIG
Q15021	S585	Sugiyama	NCAPD2 CAPD2 CNAP1 KIAA0159	ILGLIFKGPAASTQEKNPREstGNMVTGQTVCKNKPNMsDP
Q15056	S13	Sugiyama	EIF4H KIAA0038 WBSCR1 WSCR1	________MADFDtyDDRAyssFGGGRGsRGsAGGHGsRSQ
Q15056	S14	Sugiyama	EIF4H KIAA0038 WBSCR1 WSCR1	_______MADFDtyDDRAyssFGGGRGsRGsAGGHGsRSQK
Q15056	S21	Sugiyama	EIF4H KIAA0038 WBSCR1 WSCR1	MADFDtyDDRAyssFGGGRGsRGsAGGHGsRSQKELPTEPP
Q15056	S24	Sugiyama	EIF4H KIAA0038 WBSCR1 WSCR1	FDtyDDRAyssFGGGRGsRGsAGGHGsRSQKELPTEPPytA
Q15084	S169	Sugiyama	PDIA6 ERP5 P5 TXNDC7	GKQGRSDsSSKKDVIELtDDsFDKNVLDSEDVWMVEFYAPW
Q15084	S389	Sugiyama	PDIA6 ERP5 P5 TXNDC7	FALLKGsFsEQGINEFLRELsFGRGstAPVGGGAFPtIVER
Q15084	S88	Sugiyama	PDIA6 ERP5 P5 TXNDC7	AATALKDVVKVGAVDADKHHsLGGQyGVQGFPtIKIFGSNK
Q15084	T395	Sugiyama	PDIA6 ERP5 P5 TXNDC7	sFsEQGINEFLRELsFGRGstAPVGGGAFPtIVEREPWDGR
Q15185	S72	Sugiyama	PTGES3 P23 TEBP	EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE
Q15293	Y115	Sugiyama	RCN1 RCN	GDGFVttEELKtWIKRVQKRyIFDNVAKVWKDYDRDKDDKI
Q15293	Y278	Sugiyama	RCN1 RCN	LNKDGKLDKDEIRHWILPQDyDHAQAEARHLVyESDKNKDE
Q15365	S126	Sugiyama	PCBP1	ATQCGsLIGKGGCKIKEIREstGAQVQVAGDMLPNstERAI
Q15365	S27	Sugiyama	PCBP1	ESGLNVTLTIRLLMHGKEVGsIIGKKGESVKRIREEsGARI
Q15365	S50	Sugiyama	PCBP1	GKKGESVKRIREEsGARINIsEGNCPERIItLTGPTNAIFK
Q15365	T127	Sugiyama	PCBP1	TQCGsLIGKGGCKIKEIREstGAQVQVAGDMLPNstERAIT
Q15366	S126	Sugiyama	PCBP2	AsQCGsLIGKGGCKIKEIREstGAQVQVAGDMLPNstERAI
Q15366	S27	Sugiyama	PCBP2	EGGLNVTLTIRLLMHGKEVGsIIGKKGESVKKMREESGARI
Q15366	S50	Sugiyama	PCBP2	GKKGESVKKMREESGARINIsEGNCPERIITLAGPTNAIFK
Q15366	T127	Sugiyama	PCBP2	sQCGsLIGKGGCKIKEIREstGAQVQVAGDMLPNstERAIT
Q15398	S627	GPS6\|SIGNOR\|EPSD\|PSP	DLGAP5 DLG7 KIAA0008	IVFDAGFFRVEsPVKLFsGLsVssEGPsQRLGtPKsVNKAV
Q15398	S725	GPS6\|SIGNOR\|EPSD\|PSP	DLGAP5 DLG7 KIAA0008	ENHVVNKTDLKVDCLssERMsLPLLAGGVADDINTNKKEGI
Q15398	S757	GPS6\|SIGNOR\|EPSD\|PSP	DLGAP5 DLG7 KIAA0008	INTNKKEGISDVVEGMELNSsItSQDVLMssPEKNTAsQNs
Q15398	S830	GPS6\|SIGNOR\|EPSD\|PSP	DLGAP5 DLG7 KIAA0008	NCsNPFTQLERRHQEHARHIsFGGNLItFsPLQPGEF____
Q16513	S582	Sugiyama	PKN2 PRK2 PRKCL2	tVTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQD
Q16513	S583	Sugiyama	PKN2 PRK2 PRKCL2	VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs
Q16576	S163	Sugiyama	RBBP7 RBAP46	tPssDVLVFDyTKHPAKPDPsGECNPDLRLRGHQKEGYGLS
Q16600	S46	GPS6	ZNF239 HOK2 MOK2	DIsPCQQWGEAssPISRNRDsVMTLQSGCFENIESETYLPL
Q3B891	S308	GPS6	BRCA1	SSLLLTKDRMNVEKAEFCNKsKQPGLARSQHNRWAGSKETC
Q49MG5	S305	GPS6\|EPSD\|PSP	MAP9 ASAP	NKENsFSADHVTTAVEKSKEsQVTADDLEEEKAKAELIMDD
Q49MG5	S625	GPS6\|SIGNOR\|EPSD\|PSP	MAP9 ASAP	KWLENKEKQERIERKQKKRHsFLESEALPPWSPPSRTVFAK
Q58FF7	T489	Sugiyama	HSP90AB3P HSP90BC	YGWTANMEQIMKAQALRDNstMGyMMAKKHLEINPDHPIME
Q58FF8	S258	Sugiyama	HSP90AB2P HSP90BB	LAVRYFSVEEYVSRMKEIQKsIyyItGEsKEQVANSAFVEQ
Q58FG0	Y178	Sugiyama	HSP90AA5P HSP90AE	QLEELKDSRRVMKANQKHIyyItGETKDQVANSAFVECLQK
Q5QNW6	S39	Sugiyama	H2BC18 HIST2H2BF	VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q5T0N5	S488	Sugiyama	FNBP1L C1orf39 TOCA1	NEAWLSEVEGKTGGRGDRRHssDINHLVtQGREsPEGsytD
Q5T1M5	S1162	Sugiyama	FKBP15 KIAA0674	EAGstVAGAALRPsHHsQRssLsGDEEDELFKGATLKALRP
Q5T2R2	S355	Sugiyama	PDSS1 DPS1 TPRT	PVLFACQQFPEMNAMIMRRFsLPGDVDRARQYVLQSDGVQQ
Q5VTE0	T432	Sugiyama	EEF1A1P5 EEF1AL3	VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q5VZL5	T118	Sugiyama	ZMYM4 KIAA0425 ZNF262	KDNLVssIHtDDsLEVERRVtQHEsDNENEIQIQNKLKKDF
Q63ZY3	S356	Sugiyama	KANK2 ANKRD25 KIAA1518 MXRA3 SIP	PREVEVVASTAAGAPAQRAQsLEPYGtGLRALAMPGRPEsP
Q6P2Q9	T1404	Sugiyama	PRPF8 PRPC8	RVWAEYALKRQEAIAQNRRLtLEDLEDSWDRGIPRINTLFQ
Q6PEY2	S48	Sugiyama	TUBA3E	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q6PEY2	S54	Sugiyama	TUBA3E	GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q6S8J3	S1068	Sugiyama	POTEE A26C1A POTE2	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6UB35	S401	Sugiyama	MTHFD1L FTHFSDC1	IGLLADEIEIyGKSKAKVRLsVLERLKDQADGKYVLVAGIT
Q6XQN6	S500	Sugiyama	NAPRT FHIP NAPRT1	QGQLCEPLPSLAESRALAQLsLSRLSPEHRRLRsPAQYQVV
Q6ZMR3	S161	Sugiyama	LDHAL6A LDHL2	DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q6ZMR3	S167	Sugiyama	LDHAL6A LDHL2	AWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIHSESCHG
Q71U36	S48	Sugiyama	TUBA1A TUBA3	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q71U36	S54	Sugiyama	TUBA1A TUBA3	GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q71UM5	T74	Sugiyama	RPS27L	VLCVGCSTVLCQPTGGKARLtEGCsFRRKQH__________
Q7KZF4	S150	Sugiyama	SND1 TDRD11	EGLAtRREGMRANNPEQNRLsECEEQAKAAKKGMWSEGNGS
Q7KZF4	S473	Sugiyama	SND1 TDRD11	ALVSKGLATVIRYRQDDDQRssHyDELLAAEARAIKNGKGL
Q7KZF4	S727	Sugiyama	SND1 TDRD11	LEKLMENMRNDIAsHPPVEGsyAPRRGEFCIAKFVDGEWYR
Q7KZF4	Y476	Sugiyama	SND1 TDRD11	SKGLATVIRYRQDDDQRssHyDELLAAEARAIKNGKGLHSK
Q7KZI7	S40	Sugiyama	MARK2 EMK1	TLGHLDSKPssKSNMIRGRNsAtsADEQPHIGNyRLLKTIG
Q7Z417	S592	Sugiyama	NUFIP2 KIAA1321 PIG1	sPQVLGSILKsGttsEsGALsLEPsHIGDLQKADtssQGAL
Q7Z5L9	S457	Sugiyama	IRF2BP2	GSHASKDANQVHSTTRRNsNsPPsPssMNQRRLGPREVGGQ
Q7Z7G1	S331	Sugiyama	CLNK MIST	IGEYSRQAVEEAFMKENKDGsFLVRDCSTKSKEEPYVLAVF
Q86VQ1	S223	Sugiyama	GLCCI1	QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q8IX03	S539	GPS6\|SIGNOR\|EPSD\|PSP	WWC1 KIAA0869 KIBRA	QALRsLSGtPKSMTSLsPRSsLSsPSPPCsPLMADPLLAGD
Q8N142	S452	Sugiyama	ADSS1 ADSSL1	FVENHVGVAVKWVGVGKsREsMIQLF_______________
Q8NBJ7	S256	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8NHV4	S405	SIGNOR\|EPSD\|PSP	NEDD1	KEtDsGKNQDFssFDDtGKssLGDMFsPIRDDAVVNKGsDE
Q8TAM6	S280	Sugiyama	ERMN KIAA1189	TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8TD19	S332	Sugiyama	NEK9 KIAA1995 NEK8 NERCC	RREMEEKVTLLNAPTKRPRsstVtEAPIAVVTSRTSEVYVW
Q8TD47	T247	Sugiyama	RPS4Y2 RPS4Y2P	VIGNGNKPWISLPRGKGIRLtIAEERDKRLAAKQSSG____
Q8TEW0	S962	GPS6\|SIGNOR\|EPSD\|PSP\|Sugiyama	PARD3 PAR3 PAR3A	DEGMEtLEEDTEESSRsGREsVstAsDQPsHsLERQMNGNQ
Q8TF05	S538	Sugiyama	PPP4R1 MEG1 PP4R1	IDDPDVKAQVEVLSAALRAssLDAHEEtIsIEKRSDLQDEL
Q8WV24	S95	SIGNOR\|EPSD\|PSP	PHLDA1 PHRIP TDAG51	TRLSLCRDPEPPPPLCLLRVsLLCALRAGGRGSRWGEDGAR
Q8WW59	S113	Sugiyama	SPRYD4	TVKRSQQFRIGVADVDMSRDsCIGVDDRSWVFTYAQRKWYT
Q92538	S174	Sugiyama	GBF1 KIAA0248	NESVCEIMQSCFRICFEMRLsELLRKSAEHTLVDMVQLLFT
Q92688	S104	Sugiyama	ANP32B APRIL PHAPI2	AEKLPNLTHLNLsGNKLKDIstLEPLKKLECLKsLDLFNCE
Q92688	S134	Sugiyama	ANP32B APRIL PHAPI2	CLKsLDLFNCEVtNLNDyREsVFKLLPQLTYLDGyDREDQE
Q92835	S27	Sugiyama	INPP5D SHIP SHIP1	HGNITRSKAEELLSRTGKDGsFLVRAsESISRAYALCVLYR
Q92945	S193	Sugiyama	KHSRP FUBP2	DSGCKVQIsPDsGGLPERsVsLtGAPEsVQKAKMMLDDIVS
Q92945	S333	Sugiyama	KHSRP FUBP2	DRNEyGsRIGGGIDVPVPRHsVGVVIGRSGEMIKKIQNDAG
Q92974	S886	GPS6\|EPSD\|PSP	ARHGEF2 KIAA0651 LFP40	TEPLPAEAPWARRPVDPRRRsLPAGDALyLsFNPPQPSRGT
Q92974	S960	SIGNOR	ARHGEF2 KIAA0651 LFP40	ssDPDtGsEEEGssRLsPPHsPRDFtRMQDIPEEtEsRDGE
Q93073	T573	SIGNOR\|PSP	SECISBP2L KIAA0256	IASSKAKKGKEKEIAKLKRPtALKKVILKEREEKKGRLTVD
Q93079	S39	Sugiyama	H2BC9 H2BFJ HIST1H2BH	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q96CG3	T9	SIGNOR\|EPSD\|PSP	TIFA T2BP	____________MtSFEDADtEEtVTCLQMtVYHPGQLQCG
Q96CV9	S513	Sugiyama	OPTN FIP2 GLC1E HIP7 HYPL NRP	ALQLAVLLKENDAFEDGGRQsLMEMQsRHGARtsDsDQQAy
Q96CX2	S200	EPSD\|PSP	KCTD12 C13orf2 KIAA1778 PFET1	ELAsRsPsGGAAGPLLtPsQsLDGsRRSGYITIGYRGSYTI
Q96CX2	S243	SIGNOR\|EPSD\|PSP	KCTD12 C13orf2 KIAA1778 PFET1	DAQADAKFRRVARITVCGKTsLAKEVFGDtLNEsRDPDRPP
Q96D46	S462	Sugiyama	NMD3 CGI-07	FLEDLEEDEAIRKNVNIyRDsAIPVEsDtDDEGAPRISLAE
Q96EB6	T344	PSP	SIRT1 SIR2L1	SLCHKFIALSDKEGKLLRNYtQNIDTLEQVAGIQRIIQCHG
Q96EZ8	S35	EPSD\|PSP	MCRS1 INO80Q MSP58	AsGtAsRsEDEEsLAGQKRAssQALGTIPKRRSSSRFIKRK
Q96EZ8	S36	EPSD\|PSP	MCRS1 INO80Q MSP58	sGtAsRsEDEEsLAGQKRAssQALGTIPKRRSSSRFIKRKK
Q96G46	S236	Sugiyama	DUS3L	QQLRKREVRFERAEQALRRFsQGPtPAAAVPEGTAAEGAPR
Q96G46	T53	Sugiyama	DUS3L	QYLTTKEQFHQFLEAKGQEKtCREtEVGDPAGNELAEPEAK
Q96GD4	Y92	Sugiyama	AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5	FtIDDFEIGRPLGKGKFGNVyLAREKKSHFIVALKVLFKSQ
Q96HE7	S143	Sugiyama	ERO1A ERO1L UNQ434/PRO865	EANNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSD
Q96R06	S115	SIGNOR\|PSP	SPAG5	HEsDEQPLDPIPQIsstPKTsEEAVDPLGNyMVKtIVLVPs
Q96RU3	S497	Sugiyama	FNBP1 FBP17 KIAA0554	AWLAEVEGRLPARSEQARRQsGLyDSQNPPTVNNCAQDREs
Q99584	S32	Sugiyama	S100A13	SIETVVTTFFTFARQEGRKDsLsVNEFKELVTQQLPHLLKD
Q99623	S39	PSP	PHB2 BAP REA	MGTALKLLLGAGAVAYGVREsVFTVEGGHRAIFFNRIGGVQ
Q99708	S327	PSP	RBBP8 CTIP	RFSDstsKtPPQEELPtRVssPVFGATSSIKSGLDLNTsLs
Q99708	S593	PSP	RBBP8 CTIP	PSLQIKEENAVFKIPLRPREsLETENVLDDIKSAGSHEPIK
Q99733	T28	Sugiyama	NAP1L4 NAP2	DGVPsDsVEAAKNAsNtEKLtDQVMQNPRVLAALQERLDNV
Q99877	S39	Sugiyama	H2BC15 H2BFD HIST1H2BN	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99879	S39	Sugiyama	H2BC14 H2BFE HIST1H2BM	INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99880	S39	Sugiyama	H2BC13 H2BFC HIST1H2BL	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q9BQE3	S48	Sugiyama	TUBA1C TUBA6	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9BQE3	S54	Sugiyama	TUBA1C TUBA6	GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q9BQG0	S1303	EPSD\|PSP	MYBBP1A P160	KKGVLGKsPLsALARKKARLsLVIRSPsLLQSGAKKKAQVR
Q9BT25	S19	PSP	HAUS8 HICE1	__MADSSGRGAGKPATGPTNsssAKKKDKRVQGGRVIESRY
Q9BT25	S20	PSP	HAUS8 HICE1	_MADSSGRGAGKPATGPTNsssAKKKDKRVQGGRVIESRYL
Q9BTC0	S1456	Sugiyama	DIDO1 C20orf158 DATF1 KIAA0333	EAKVTVDDLPNRMCADVRRNsVERPAEPVAGAAtPsLVEQQ
Q9BXS6	S240	GPS6\|EPSD\|PSP	NUSAP1 ANKT BM-037 PRO0310	KQQPINKGGVRTPVPPRGRLsVAstPIsQRRsQGRsCGPAs
Q9BYX7	S368	Sugiyama	POTEKP ACTBL3 FKSG30	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9BZB8	T172	GPS6	CPEB1 CPEB	LGSDLVDKFPAPSVRGSRLDtRPILDsRsssPsDSDTSGFS
Q9C0C2	S1331	Sugiyama	TNKS1BP1 KIAA1741 TAB182	WGNNLGLRDLEVtCDPDsGGsQGLRGCGVGQMDWTQDLAPQ
Q9C0C2	S1371	Sugiyama	TNKS1BP1 KIAA1741 TAB182	QNVELFGAPSEAREHGVGGVsQCPEPGLRHNGsLsPGLEAR
Q9C0C2	S429	Sugiyama	TNKS1BP1 KIAA1741 TAB182	EEEAKGDAHLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAA
Q9C0C2	S714	Sugiyama	TNKS1BP1 KIAA1741 TAB182	PsGGGARRGAGAELKDtQsPstCsEGLLGWsQKDLQSEFGI
Q9C0C2	S717	Sugiyama	TNKS1BP1 KIAA1741 TAB182	GGARRGAGAELKDtQsPstCsEGLLGWsQKDLQSEFGITGD
Q9C0C2	S936	Sugiyama	TNKS1BP1 KIAA1741 TAB182	GRyssQDADEQDWEFQKRDVsLGTyGSRAAEPQEQEFGKSA
Q9C0C2	S983	Sugiyama	TNKS1BP1 KIAA1741 TAB182	sGGsSRtLDAQDRsFGtRPLssGFsPEEAQQQDEEFEKKIP
Q9GZM8	S251	GPS6\|SIGNOR	NDEL1 EOPA MITAP1 NUDEL	sPKAIPNGFGTsPLtPSARIsALNIVGDLLRKVGALESKLA
Q9H008	S241	Sugiyama	LHPP	GGAQRCGMRALQVRTGKFRPsDEHHPEVKADGYVDNLAEAV
Q9H0B6	S428	Sugiyama	KLC2	NKPIWMHAEEREESKDKRRDsAPyGEyGsWYKACKVDsPtV
Q9H0B6	Y376	Sugiyama	KLC2	TRLGPDDPNVAKTKNNLAsCyLKQGKYQDAETLYKEILTRA
Q9H173	T125	Sugiyama	SIL1 UNQ545/PRO836	QYEDKFRNNLKGKRLDINtNtytsQDLKSALAKFKEGAEME
Q9H2G2	S340	Sugiyama	SLK KIAA0204 STK2	EEDEEEEtENsLPIPAsKRAssDLsIAssEEDKLsQNACIL
Q9H7D7	S121	Sugiyama	WDR26 CDW2 MIP2 PRO0852	ASSSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLN
Q9H814	S149	Sugiyama	PHAX RNUXA	AVATELGILGMEGTIDRsRQsEtyNyLLAKKLRKESQEHTK
Q9HC77	S467	EPSD\|PSP	CPAP CENPJ LAP LIP1	KSGSVTLSQKPKMLKCSNRKsLsPSGLKIQTGKKCDGQFRD
Q9NR45	S253	Sugiyama	NANS SAS	KVLERHITLDKTWKGsDHsAsLEPGELAELVRSVRLVERAL
Q9NRF8	S568	Sugiyama	CTPS2	TGNLNAYLQQGCKLsssDRysDAsDDsFSEPRIAELEIS__
Q9NRL3	T338	Sugiyama	STRN4 ZIN	EFDFLGSGEDGEGAPDPRRCtVDGsPHELESRRVKLQGILA
Q9NRM7	S380	GPS6\|SIGNOR\|EPSD\|PSP	LATS2 KPM	YELGSTSVQQWPAATLARRDsLQKPGLEAPPRAHVAFRPDC
Q9NRM7	S83	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	LATS2 KPM	QMRATPKFGPYQKALREIRYsLLPFANESGTSAAAEVNRQM
Q9NRX4	S80	Sugiyama	PHPT1 PHP14 CGI-202 HSPC141	VSGDMQKQGCDCECLGGGRIsHQSQDKKIHVyGysMAyGPA
Q9NS23	S207	SIGNOR	RASSF1 RDA32	PsLQDARRGPGRGTSVRRRtsFYLPKDAVKHLHVLSRTRAR
Q9NS23	T206	SIGNOR	RASSF1 RDA32	PPsLQDARRGPGRGTSVRRRtsFYLPKDAVKHLHVLSRTRA
Q9NSK0	Y389	Sugiyama	KLC4 KNSL8	GQLGPDNPNVARTKNNLAsCyLKQGKYAEAETLYKEILTRA
Q9NWT8	S70	SIGNOR\|PSP	AURKAIP1 AIP AKIP MRPS38	SLPRKGAQLELEEMLVPRKMsVSPLESWLTARCFLPRLDTG
Q9NXH9	S514	Sugiyama	TRMT1	ALWDIMRCWEKECPVKRERLsETsPAFRILsVEPRLQANFT
Q9NYF8	S320	Sugiyama	BCLAF1 BTF KIAA0164	sPAKtIAPQNAPRDEsRGRssFyPDGGDQETAKtGKFLKRF
Q9UBT2	S507	Sugiyama	UBA2 SAE2 UBLE1B HRIHFB2115	GTILISsEEGETEANNHKKLsEFGIRNGSRLQADDFLQDYT
Q9UBU9	S431	Sugiyama	NXF1 TAP	HDGACCSLSIPFIPQNPARSsLAEyFKDSRNVKKLKDPTLR
Q9UGV2	S333	Sugiyama	NDRG3	MGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsD
Q9UGV2	S334	Sugiyama	NDRG3	GYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsDG
Q9UGV2	S335	Sugiyama	NDRG3	YIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsDGt
Q9UGV2	T332	Sugiyama	NDRG3	GMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQs
Q9UI15	S185	Sugiyama	TAGLN3 NP25	EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9ULD2	S1203	Sugiyama	MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1	QENEELKARMDKHMAISRQLstEQAVLQESLEKESKVNKRL
Q9ULW0	S121	SIGNOR\|EPSD\|PSP	TPX2 C20orf1 C20orf2 DIL2 HCA519	ssLEVEAAISRKTPAQPQRRsLRLsAQKDLEQKEKHHVKMK
Q9ULW0	S125	SIGNOR\|EPSD\|PSP	TPX2 C20orf1 C20orf2 DIL2 HCA519	VEAAISRKTPAQPQRRsLRLsAQKDLEQKEKHHVKMKAKRC
Q9ULX3	S390	Sugiyama	NOB1 ART4 NOB1P PSMD8BP1 MSTP158	VsPFVENDISSRSATLQVRDsTLGAGRRRLNPNASRKKFVK
Q9UNN5	S289	SIGNOR\|EPSD\|PSP	FAF1 UBXD12 UBXN3A CGI-03	ssPAQTREQSEEQITDVHMVsDsDGDDFEDATEFGVDDGEV
Q9UNN5	S291	SIGNOR\|EPSD\|PSP	FAF1 UBXD12 UBXN3A CGI-03	PAQTREQSEEQITDVHMVsDsDGDDFEDATEFGVDDGEVFG
Q9UPQ0	S201	Sugiyama	LIMCH1 KIAA1102	DCWDsERsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVV
Q9UPQ0	S207	Sugiyama	LIMCH1 KIAA1102	RsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVVLRGssD
Q9UPU5	S1360	Sugiyama	USP24 KIAA1057	AAAAGRLDLVGSsQPIKESNsLCPAGIRNRLsssGsNCssG
Q9UPY8	S176	SIGNOR\|EPSD\|PSP	MAPRE3	AVPQRtsPtGPKNMQTSGRLsNVAPPCILRKNPPSARNGGH
Q9UQ35	S2692	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9UQB9	Y58	Sugiyama	AURKC AIE2 AIK3 AIRK3 ARK3 STK13	LTVDDFEIGRPLGKGKFGNVyLARLKESHFIVALKVLFKSQ
Q9Y230	S43	Sugiyama	RUVBL2 INO80J TIP48 TIP49B CGI-46	GAHSHIRGLGLDDALEPRQAsQGMVGQLAARRAAGVVLEMI
Q9Y266	S298	Sugiyama	NUDC	DLDsEtRsMVEKMMYDQRQKsMGLPtsDEQKKQEILKKFMD
Q9Y2B0	S65	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y657	S109	SIGNOR\|PSP	SPIN1 OCR SPIN	IKYDGFDCVYGLELNKDERVsALEVLPDRVAtsRIsDAHLA
Q9Y657	S124	SIGNOR\|PSP	SPIN1 OCR SPIN	KDERVsALEVLPDRVAtsRIsDAHLADTMIGKAVEHMFETE
Q9Y696	S27	Sugiyama	CLIC4	LNGLKEEDKEPLIELFVKAGsDGEsIGNCPFSQRLFMILWL
Q9Y696	S31	Sugiyama	CLIC4	KEEDKEPLIELFVKAGsDGEsIGNCPFSQRLFMILWLKGVV
Q9Y6A5	S34	SIGNOR	TACC3 ERIC1	EKNTENCDFLFsPPEVTGRSsVLRVsQKENVPPKNLAKAMK
Q9Y6A5	S552	SIGNOR	TACC3 ERIC1	LGTGAEVDyLEQFGTSSFKEsALRKQsLYLKFDPLLRDsPG
Q9Y6A5	S558	GPS6\|SIGNOR\|EPSD\|PSP	TACC3 ERIC1	VDyLEQFGTSSFKEsALRKQsLYLKFDPLLRDsPGRPVPVA

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p	ref_path	ref_path_lowest
Signal Transduction	R-HSA-162582	0.000003	5.601	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	0.000004	5.433	0	0
NRAGE signals death through JNK	R-HSA-193648	0.000003	5.469	0	0
Meiotic synapsis	R-HSA-1221632	0.000005	5.308	0	0
Chromatin modifying enzymes	R-HSA-3247509	0.000008	5.115	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	0.000010	5.006	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	0.000012	4.907	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	0.000013	4.885	0	0
Cell Cycle	R-HSA-1640170	0.000013	4.876	1	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	0.000014	4.840	0	0
Cell Cycle Checkpoints	R-HSA-69620	0.000015	4.818	0	0
Chromatin organization	R-HSA-4839726	0.000021	4.685	0	0
Apoptotic execution phase	R-HSA-75153	0.000025	4.597	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	0.000026	4.577	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	0.000048	4.316	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	0.000052	4.281	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	0.000060	4.222	0	0
HDACs deacetylate histones	R-HSA-3214815	0.000071	4.149	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	0.000082	4.088	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	0.000091	4.040	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	0.000091	4.042	0	0
Packaging Of Telomere Ends	R-HSA-171306	0.000100	3.998	0	0
Regulation of TP53 Activity	R-HSA-5633007	0.000106	3.976	1	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	0.000122	3.912	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	0.000126	3.900	0	0
G alpha (12/13) signalling events	R-HSA-416482	0.000131	3.883	0	0
Cell Cycle, Mitotic	R-HSA-69278	0.000143	3.844	1	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	0.000165	3.782	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	0.000180	3.745	0	0
Nucleosome assembly	R-HSA-774815	0.000180	3.745	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	0.000202	3.695	0	0
Death Receptor Signaling	R-HSA-73887	0.000203	3.693	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	0.000252	3.599	0	0
Nervous system development	R-HSA-9675108	0.000249	3.604	0	0
DNA Double Strand Break Response	R-HSA-5693606	0.000284	3.547	0	0
Axon guidance	R-HSA-422475	0.000304	3.517	0	0
Diseases of programmed cell death	R-HSA-9645723	0.000332	3.479	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	0.000350	3.456	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	0.000410	3.387	0	0
Meiosis	R-HSA-1500620	0.000410	3.387	0	0
RET signaling	R-HSA-8853659	0.000456	3.341	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	0.000506	3.296	0	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	0.000511	3.291	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	0.000550	3.259	0	0
Signaling by Hippo	R-HSA-2028269	0.000561	3.251	0	0
Cleavage of the damaged purine	R-HSA-110331	0.000575	3.240	0	0
DNA methylation	R-HSA-5334118	0.000604	3.219	0	0
Activation of RAC1	R-HSA-428540	0.000715	3.146	0	0
Depurination	R-HSA-73927	0.000719	3.143	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	0.000729	3.137	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	0.000849	3.071	0	0
Signaling by ROBO receptors	R-HSA-376176	0.000825	3.084	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	0.000849	3.071	0	0
G2/M DNA damage checkpoint	R-HSA-69473	0.000901	3.045	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	0.001101	2.958	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	0.001115	2.953	0	0
RNA Polymerase I Promoter Opening	R-HSA-73728	0.001148	2.940	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	0.001223	2.913	0	0
PRC2 methylates histones and DNA	R-HSA-212300	0.001320	2.879	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	0.001383	2.859	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	0.001624	2.790	0	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	0.001574	2.803	0	0
Cellular Senescence	R-HSA-2559583	0.001688	2.773	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	0.001707	2.768	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	0.001869	2.728	0	0
MTOR signalling	R-HSA-165159	0.001986	2.702	0	0
Intracellular signaling by second messengers	R-HSA-9006925	0.001909	2.719	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	0.002785	2.555	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	0.002894	2.539	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	0.003108	2.507	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	0.003133	2.504	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	0.003231	2.491	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	0.003434	2.464	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	0.003478	2.459	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	0.003515	2.454	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	0.003619	2.441	0	0
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	0.003619	2.441	0	0
Mitotic Prophase	R-HSA-68875	0.003843	2.415	0	0
Estrogen-dependent gene expression	R-HSA-9018519	0.004092	2.388	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	0.004160	2.381	1	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	0.004126	2.384	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	0.004380	2.359	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	0.004583	2.339	0	0
Amplification of signal from the kinetochores	R-HSA-141424	0.004583	2.339	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	0.004557	2.341	1	0
G2/M Checkpoints	R-HSA-69481	0.004629	2.334	0	0
MITF-M-dependent gene expression	R-HSA-9856651	0.005138	2.289	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	0.005047	2.297	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	0.005193	2.285	0	0
Neurodegenerative Diseases	R-HSA-8863678	0.005193	2.285	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	0.004978	2.303	0	0
Depyrimidination	R-HSA-73928	0.004978	2.303	0	0
DARPP-32 events	R-HSA-180024	0.005333	2.273	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	0.005547	2.256	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	0.005552	2.256	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	0.005858	2.232	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	0.006097	2.215	0	0
HDMs demethylate histones	R-HSA-3214842	0.006465	2.189	0	0
Interleukin-37 signaling	R-HSA-9008059	0.006515	2.186	0	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	0.007230	2.141	0	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	0.007230	2.141	0	0
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	0.007230	2.141	0	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	0.007230	2.141	0	0
RNA Polymerase I Transcription	R-HSA-73864	0.007079	2.150	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	0.007223	2.141	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	0.007223	2.141	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	0.006912	2.160	0	0
HATs acetylate histones	R-HSA-3214847	0.007266	2.139	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	0.007306	2.136	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	0.007782	2.109	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	0.007814	2.107	0	0
Oncogenic MAPK signaling	R-HSA-6802957	0.008052	2.094	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	0.008051	2.094	0	0
Apoptosis	R-HSA-109581	0.008169	2.088	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	0.008551	2.068	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	0.008599	2.066	0	0
Meiotic recombination	R-HSA-912446	0.008658	2.063	0	0
ChREBP activates metabolic gene expression	R-HSA-163765	0.009020	2.045	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	0.009695	2.013	0	0
PIP3 activates AKT signaling	R-HSA-1257604	0.009662	2.015	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	0.010064	1.997	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	0.010732	1.969	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	0.010732	1.969	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	0.011320	1.946	0	0
Cell junction organization	R-HSA-446728	0.011709	1.931	0	0
Germ layer formation at gastrulation	R-HSA-9754189	0.011716	1.931	0	0
Rap1 signalling	R-HSA-392517	0.011716	1.931	0	0
Muscle contraction	R-HSA-397014	0.012662	1.898	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	0.012341	1.909	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	0.012341	1.909	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	0.013035	1.885	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	0.013156	1.881	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	0.013410	1.873	0	0
Defective pyroptosis	R-HSA-9710421	0.013574	1.867	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	0.013807	1.860	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	0.013814	1.860	0	0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	0.013994	1.854	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	0.013994	1.854	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	0.014609	1.835	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	0.014689	1.833	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	0.014689	1.833	0	0
Protein-protein interactions at synapses	R-HSA-6794362	0.015305	1.815	0	0
RAF activation	R-HSA-5673000	0.015780	1.802	0	0
Repression of WNT target genes	R-HSA-4641265	0.016372	1.786	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	0.016372	1.786	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	0.017107	1.767	0	0
Signaling by FGFR in disease	R-HSA-1226099	0.017205	1.764	0	0
Homology Directed Repair	R-HSA-5693538	0.017614	1.754	0	0
mRNA Splicing	R-HSA-72172	0.017792	1.750	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	0.018159	1.741	0	0
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	0.018840	1.725	0	0
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	0.018840	1.725	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	0.018684	1.729	1	1
PKMTs methylate histone lysines	R-HSA-3214841	0.019666	1.706	0	0
Cell-Cell communication	R-HSA-1500931	0.020453	1.689	0	0
Reproduction	R-HSA-1474165	0.019310	1.714	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	0.020508	1.688	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	0.020508	1.688	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	0.020508	1.688	0	0
Signaling by RAS mutants	R-HSA-6802949	0.020508	1.688	0	0
RNA Polymerase II Transcription	R-HSA-73857	0.020927	1.679	1	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	0.020931	1.679	0	0
mRNA 3'-end processing	R-HSA-72187	0.021047	1.677	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	0.021047	1.677	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	0.021387	1.670	0	0
Assembly of the pre-replicative complex	R-HSA-68867	0.022100	1.656	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	0.023408	1.631	0	0
MET interacts with TNS proteins	R-HSA-8875513	0.025509	1.593	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	0.024776	1.606	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	0.025887	1.587	0	0
mTORC1-mediated signalling	R-HSA-166208	0.026363	1.579	0	0
M Phase	R-HSA-68886	0.024463	1.611	0	0
Developmental Biology	R-HSA-1266738	0.025577	1.592	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	0.026759	1.573	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	0.027050	1.568	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	0.027050	1.568	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	0.027253	1.565	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	0.027253	1.565	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	0.029821	1.525	0	0
Regulation of endogenous retroelements	R-HSA-9842860	0.030270	1.519	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	0.032792	1.484	0	0
Netrin-1 signaling	R-HSA-373752	0.033231	1.478	0	0
Cardiac conduction	R-HSA-5576891	0.033564	1.474	0	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	0.037994	1.420	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	0.037994	1.420	0	0
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	0.037994	1.420	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	0.037994	1.420	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	0.037994	1.420	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	0.033830	1.471	0	0
Chromosome Maintenance	R-HSA-73886	0.036557	1.437	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	0.036225	1.441	0	0
Gene expression (Transcription)	R-HSA-74160	0.033883	1.470	1	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	0.037124	1.430	0	0
Semaphorin interactions	R-HSA-373755	0.036706	1.435	0	0
Post NMDA receptor activation events	R-HSA-438064	0.036376	1.439	0	0
Regulation of PTEN localization	R-HSA-8948747	0.037994	1.420	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	0.038131	1.419	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	0.039677	1.401	0	0
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	0.040283	1.395	0	0
Programmed Cell Death	R-HSA-5357801	0.041422	1.383	0	0
Phase 4 - resting membrane potential	R-HSA-5576886	0.041597	1.381	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	0.041717	1.380	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	0.041835	1.378	0	0
FLT3 Signaling	R-HSA-9607240	0.041900	1.378	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	0.042079	1.376	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	0.043512	1.361	0	0
MAPK family signaling cascades	R-HSA-5683057	0.043825	1.358	0	0
Type I hemidesmosome assembly	R-HSA-446107	0.050596	1.296	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	0.050596	1.296	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	0.050596	1.296	0	0
Signaling by RAF1 mutants	R-HSA-9656223	0.047212	1.326	0	0
MAP2K and MAPK activation	R-HSA-5674135	0.047212	1.326	0	0
Generic Transcription Pathway	R-HSA-212436	0.048933	1.310	1	0
Negative regulation of MAPK pathway	R-HSA-5675221	0.047212	1.326	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	0.046014	1.337	0	0
Mitotic G2-G2/M phases	R-HSA-453274	0.047948	1.319	1	0
Calmodulin induced events	R-HSA-111933	0.046827	1.330	0	0
CaM pathway	R-HSA-111997	0.046827	1.330	0	0
Ub-specific processing proteases	R-HSA-5689880	0.044739	1.349	0	0
Kinesins	R-HSA-983189	0.050394	1.298	0	0
Cell-cell junction organization	R-HSA-421270	0.050838	1.294	0	0
ESR-mediated signaling	R-HSA-8939211	0.051017	1.292	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	0.052217	1.282	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	0.052217	1.282	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	0.052217	1.282	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	0.052217	1.282	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	0.052217	1.282	0	0
Breakdown of the nuclear lamina	R-HSA-352238	0.054776	1.261	0	0
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	0.054776	1.261	0	0
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	0.054776	1.261	0	0
Signaling by TCF7L2 mutants	R-HSA-5339700	0.054776	1.261	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	0.055336	1.257	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	0.057618	1.239	0	0
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	0.058496	1.233	0	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	0.058496	1.233	0	0
Activation of ATR in response to replication stress	R-HSA-176187	0.059446	1.226	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	0.059652	1.224	0	0
Lipophagy	R-HSA-9613354	0.065210	1.186	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	0.065210	1.186	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	0.071194	1.148	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	0.071194	1.148	0	0
Ephrin signaling	R-HSA-3928664	0.071194	1.148	0	0
GP1b-IX-V activation signalling	R-HSA-430116	0.065210	1.186	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	0.064603	1.190	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	0.066844	1.175	0	0
Ion homeostasis	R-HSA-5578775	0.062677	1.203	0	0
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	0.065210	1.186	0	0
FOXO-mediated transcription	R-HSA-9614085	0.065097	1.186	0	0
Defects in biotin (Btn) metabolism	R-HSA-3323169	0.065210	1.186	0	0
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	0.064120	1.193	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	0.068805	1.162	0	0
Unwinding of DNA	R-HSA-176974	0.065210	1.186	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	0.071194	1.148	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	0.068205	1.166	0	0
Interleukin-1 processing	R-HSA-448706	0.065210	1.186	0	0
DAG and IP3 signaling	R-HSA-1489509	0.072959	1.137	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	0.074566	1.127	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	0.074819	1.126	1	1
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	0.075613	1.121	0	0
Regulation of gene expression in beta cells	R-HSA-210745	0.075787	1.120	0	0
RAF/MAP kinase cascade	R-HSA-5673001	0.076340	1.117	0	0
Neurexins and neuroligins	R-HSA-6794361	0.078018	1.108	0	0
Adherens junctions interactions	R-HSA-418990	0.078398	1.106	0	0
Signaling by VEGF	R-HSA-194138	0.078554	1.105	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	0.079841	1.098	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	0.079902	1.097	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	0.080991	1.092	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	0.081779	1.087	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	0.081779	1.087	0	0
Tandem pore domain potassium channels	R-HSA-1296346	0.081779	1.087	0	0
Regulation of TP53 Expression	R-HSA-6804754	0.089893	1.046	0	0
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	0.089893	1.046	0	0
Signaling by APC mutants	R-HSA-4839744	0.100204	0.999	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	0.100204	0.999	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	0.100204	0.999	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	0.100204	0.999	0	0
DCC mediated attractive signaling	R-HSA-418885	0.092078	1.036	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	0.092078	1.036	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	0.092078	1.036	0	0
G1/S-Specific Transcription	R-HSA-69205	0.094231	1.026	0	0
Telomere Maintenance	R-HSA-157579	0.089676	1.047	0	0
Eukaryotic Translation Elongation	R-HSA-156842	0.094397	1.025	0	0
DNA Replication Pre-Initiation	R-HSA-69002	0.086246	1.064	0	0
Mitotic Prometaphase	R-HSA-68877	0.087534	1.058	0	0
Activation of BH3-only proteins	R-HSA-114452	0.085645	1.067	0	0
Sema4D in semaphorin signaling	R-HSA-400685	0.097134	1.013	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	0.098426	1.007	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	0.097153	1.013	0	0
Regulation of TP53 Degradation	R-HSA-6804757	0.094231	1.026	0	0
Biotin transport and metabolism	R-HSA-196780	0.092078	1.036	0	0
G2/M Transition	R-HSA-69275	0.087907	1.056	1	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	0.084615	1.073	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	0.092078	1.036	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	0.096227	1.017	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	0.083942	1.076	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	0.099588	1.002	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	0.089676	1.047	0	0
NGF-stimulated transcription	R-HSA-9031628	0.097197	1.012	0	0
Signaling by ERBB4	R-HSA-1236394	0.095457	1.020	0	0
Formation of the nephric duct	R-HSA-9830364	0.097134	1.013	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	0.098376	1.007	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	0.100948	0.996	0	0
Ca-dependent events	R-HSA-111996	0.100948	0.996	0	0
Protein ubiquitination	R-HSA-8852135	0.102705	0.988	0	0
G0 and Early G1	R-HSA-1538133	0.107492	0.969	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	0.107492	0.969	0	0
Signaling by WNT in cancer	R-HSA-4791275	0.107492	0.969	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	0.108055	0.966	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	0.109666	0.960	0	0
Signaling by EGFR	R-HSA-177929	0.110384	0.957	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	0.115569	0.937	0	0
Signaling by ALK in cancer	R-HSA-9700206	0.115569	0.937	0	0
PI3K Cascade	R-HSA-109704	0.115729	0.937	0	0
Drug resistance of PDGFR mutants	R-HSA-9674415	0.117294	0.931	0	0
PDGFR mutants bind TKIs	R-HSA-9674428	0.117294	0.931	0	0
Imatinib-resistant PDGFR mutants	R-HSA-9674396	0.117294	0.931	0	0
Sunitinib-resistant PDGFR mutants	R-HSA-9674401	0.117294	0.931	0	0
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	0.117294	0.931	0	0
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	0.117294	0.931	0	0
Loss of Function of TP53 in Cancer	R-HSA-9723907	0.117294	0.931	0	0
Sorafenib-resistant PDGFR mutants	R-HSA-9674404	0.117294	0.931	0	0
Regorafenib-resistant PDGFR mutants	R-HSA-9674403	0.117294	0.931	0	0
Epigenetic regulation of gene expression	R-HSA-212165	0.118522	0.926	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	0.119462	0.923	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	0.119462	0.923	0	0
IRS-mediated signalling	R-HSA-112399	0.119541	0.922	0	0
Signaling by AXIN mutants	R-HSA-4839735	0.120358	0.920	0	0
Signaling by AMER1 mutants	R-HSA-4839748	0.120358	0.920	0	0
Base Excision Repair	R-HSA-73884	0.120789	0.918	0	0
Signaling by FGFR1 amplification mutants	R-HSA-1839120	0.129778	0.887	0	0
Activation of BIM and translocation to mitochondria	R-HSA-111446	0.129778	0.887	0	0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	0.129778	0.887	0	0
MET activates PTPN11	R-HSA-8865999	0.129778	0.887	0	0
TRIF-mediated programmed cell death	R-HSA-2562578	0.130942	0.883	0	0
SOS-mediated signalling	R-HSA-112412	0.130942	0.883	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	0.125337	0.902	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	0.125337	0.902	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	0.123011	0.910	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	0.123011	0.910	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	0.123011	0.910	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	0.152027	0.818	0	0
snRNP Assembly	R-HSA-191859	0.139102	0.857	0	0
Metabolism of non-coding RNA	R-HSA-194441	0.139102	0.857	0	0
AURKA Activation by TPX2	R-HSA-8854518	0.141270	0.850	1	1
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	0.142800	0.845	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	0.136457	0.865	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	0.142800	0.845	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	0.132102	0.879	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	0.130942	0.883	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	0.145408	0.837	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	0.141324	0.850	0	0
IGF1R signaling cascade	R-HSA-2428924	0.122480	0.912	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	0.137143	0.863	0	0
Rab regulation of trafficking	R-HSA-9007101	0.150950	0.821	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	0.131688	0.880	0	0
Nuclear import of Rev protein	R-HSA-180746	0.145408	0.837	0	0
Signaling by NTRKs	R-HSA-166520	0.145476	0.837	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	0.141324	0.850	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	0.128484	0.891	0	0
Amyloid fiber formation	R-HSA-977225	0.152997	0.815	0	0
Drug-mediated inhibition of MET activation	R-HSA-9734091	0.220836	0.656	0	0
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	0.220836	0.656	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	0.220836	0.656	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	0.220836	0.656	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	0.220836	0.656	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	0.220836	0.656	0	0
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	0.220836	0.656	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	0.220836	0.656	0	0
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	0.220836	0.656	0	0
Tandem pore domain halothane-inhibited K+ channel (THIK)	R-HSA-1299287	0.220836	0.656	0	0
Defective SLC26A4 causes Pendred syndrome (PDS)	R-HSA-5619046	0.220836	0.656	0	0
Regulation of gap junction activity	R-HSA-191650	0.172831	0.762	0	0
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	0.172831	0.762	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	0.172831	0.762	0	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	0.172831	0.762	0	0
t(4;14) translocations of FGFR3	R-HSA-2033515	0.312238	0.506	0	0
Signaling by FGFR3 fusions in cancer	R-HSA-8853334	0.312238	0.506	0	0
Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP)	R-HSA-5619053	0.312238	0.506	0	0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5619081	0.312238	0.506	0	0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5660724	0.312238	0.506	0	0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	0.312238	0.506	0	0
MyD88 deficiency (TLR5)	R-HSA-5602680	0.312238	0.506	0	0
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	0.312238	0.506	0	0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	R-HSA-5083628	0.312238	0.506	0	0
Intestinal infectious diseases	R-HSA-8942233	0.312238	0.506	0	0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	0.312238	0.506	0	0
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	0.312238	0.506	0	0
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	0.312238	0.506	0	0
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	0.312238	0.506	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	0.217759	0.662	0	0
SMAC (DIABLO) binds to IAPs	R-HSA-111463	0.217759	0.662	0	0
IRS activation	R-HSA-74713	0.217759	0.662	0	0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	0.217759	0.662	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	0.217759	0.662	0	0
G2 Phase	R-HSA-68911	0.217759	0.662	0	0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	0.159810	0.796	0	0
FGFR1b ligand binding and activation	R-HSA-190370	0.159810	0.796	0	0
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	0.263533	0.579	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	0.263533	0.579	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	0.263533	0.579	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	0.263533	0.579	0	0
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	0.263533	0.579	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	0.392923	0.406	0	0
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	0.392923	0.406	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	0.392923	0.406	0	0
Regulation of cortical dendrite branching	R-HSA-8985801	0.392923	0.406	0	0
Interaction between PHLDA1 and AURKA	R-HSA-8854521	0.392923	0.406	1	1
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	0.392923	0.406	0	0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)	R-HSA-5619049	0.392923	0.406	0	0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	0.392923	0.406	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	0.392923	0.406	0	0
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	0.392923	0.406	0	0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	R-HSA-5083629	0.392923	0.406	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	0.392923	0.406	0	0
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	0.392923	0.406	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	0.392923	0.406	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	0.392923	0.406	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	0.392923	0.406	0	0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	R-HSA-5083633	0.392923	0.406	0	0
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	0.392923	0.406	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	0.392923	0.406	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	0.392923	0.406	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	0.392923	0.406	0	0
Potassium transport channels	R-HSA-1296067	0.392923	0.406	0	0
TWIK related potassium channel (TREK)	R-HSA-1299503	0.392923	0.406	0	0
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	0.392923	0.406	0	0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)	R-HSA-5655799	0.392923	0.406	0	0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	0.165238	0.782	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	0.165238	0.782	0	0
FGFR3 mutant receptor activation	R-HSA-2033514	0.165238	0.782	0	0
Signaling by activated point mutants of FGFR3	R-HSA-1839130	0.165238	0.782	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	0.165238	0.782	0	0
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	0.309335	0.510	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	0.255105	0.593	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	0.215042	0.667	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	0.183641	0.736	0	0
Deadenylation of mRNA	R-HSA-429947	0.175899	0.755	0	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	0.241329	0.617	0	0
Differentiation of T cells	R-HSA-9945266	0.241329	0.617	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	0.288546	0.540	0	0
Signaling by activated point mutants of FGFR1	R-HSA-1839122	0.288546	0.540	0	0
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	0.354530	0.450	0	0
MET activates PI3K/AKT signaling	R-HSA-8851907	0.354530	0.450	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	0.354530	0.450	0	0
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	0.354530	0.450	0	0
Netrin mediated repulsion signals	R-HSA-418886	0.354530	0.450	0	0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	0.354530	0.450	0	0
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	0.464146	0.333	0	0
Signaling by plasma membrane FGFR1 fusions	R-HSA-8853336	0.464146	0.333	0	0
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	0.464146	0.333	0	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	0.464146	0.333	0	0
3-Methylcrotonyl-CoA carboxylase deficiency	R-HSA-9909438	0.464146	0.333	0	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	0.464146	0.333	0	0
Defective ABCA3 causes SMDP3	R-HSA-5683678	0.464146	0.333	0	0
Defective ABCA3 causes SMDP3	R-HSA-5688399	0.464146	0.333	0	0
IRAK4 deficiency (TLR5)	R-HSA-5603037	0.464146	0.333	0	0
Invadopodia formation	R-HSA-8941237	0.464146	0.333	0	0
Defective SLC7A7 causes lysinuric protein intolerance (LPI)	R-HSA-5660862	0.464146	0.333	0	0
Classical Kir channels	R-HSA-1296053	0.464146	0.333	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	0.167625	0.776	0	0
Tight junction interactions	R-HSA-420029	0.194360	0.711	0	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	0.268291	0.571	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	0.268291	0.571	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	0.183893	0.735	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	0.183893	0.735	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	0.322281	0.492	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	0.322281	0.492	0	0
FRS-mediated FGFR3 signaling	R-HSA-5654706	0.249884	0.602	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	0.249884	0.602	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	0.233277	0.632	0	0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	0.398630	0.399	0	0
MET receptor recycling	R-HSA-8875656	0.398630	0.399	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	0.218247	0.661	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	0.273200	0.564	0	0
Translation initiation complex formation	R-HSA-72649	0.158312	0.800	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	0.253581	0.596	0	0
Formation of axial mesoderm	R-HSA-9796292	0.356029	0.449	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	0.236227	0.627	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	0.323530	0.490	0	0
GAB1 signalosome	R-HSA-180292	0.323530	0.490	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	0.323530	0.490	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	0.274346	0.562	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	0.182983	0.738	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	0.182983	0.738	0	0
Centrosome maturation	R-HSA-380287	0.162223	0.790	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	0.273516	0.563	0	0
Activation of the pre-replicative complex	R-HSA-68962	0.295493	0.529	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	0.295493	0.529	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	0.321007	0.493	0	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	0.351473	0.454	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	0.351473	0.454	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	0.351473	0.454	0	0
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	0.389542	0.409	0	0
ALK mutants bind TKIs	R-HSA-9700645	0.441270	0.355	0	0
HCN channels	R-HSA-1296061	0.527017	0.278	0	0
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	0.527017	0.278	0	0
Defective CP causes aceruloplasminemia (ACERULOP)	R-HSA-5619060	0.527017	0.278	0	0
Peptide chain elongation	R-HSA-156902	0.162386	0.789	0	0
EGFR downregulation	R-HSA-182971	0.316943	0.499	0	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	0.345279	0.462	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	0.379426	0.421	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	0.379426	0.421	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	0.379426	0.421	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	0.379426	0.421	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	0.379426	0.421	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	0.422604	0.374	0	0
Erythropoietin activates RAS	R-HSA-9027284	0.422604	0.374	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	0.422604	0.374	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	0.422604	0.374	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	0.422604	0.374	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	0.281216	0.551	0	0
MET promotes cell motility	R-HSA-8875878	0.331902	0.479	0	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	0.407248	0.390	0	0
SHC-mediated cascade:FGFR3	R-HSA-5654704	0.407248	0.390	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	0.407248	0.390	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	0.482186	0.317	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	0.482186	0.317	0	0
2-LTR circle formation	R-HSA-164843	0.482186	0.317	0	0
Folding of actin by CCT/TriC	R-HSA-390450	0.482186	0.317	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	0.214482	0.669	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	0.214482	0.669	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	0.351785	0.454	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	0.256050	0.592	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	0.248057	0.605	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	0.382348	0.418	0	0
Striated Muscle Contraction	R-HSA-390522	0.382348	0.418	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	0.455031	0.342	0	0
Phosphorylation of the APC/C	R-HSA-176412	0.455031	0.342	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	0.455031	0.342	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	0.426109	0.370	0	0
Signaling by Erythropoietin	R-HSA-9006335	0.442475	0.354	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	0.486667	0.313	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	0.486667	0.313	0	0
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	0.521195	0.283	0	0
Regulation of MITF-M dependent genes involved in invasion	R-HSA-9854909	0.582514	0.235	0	0
Activation of AMPA receptors	R-HSA-399710	0.582514	0.235	0	0
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	0.582514	0.235	0	0
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	0.582514	0.235	0	0
FGFR1c and Klotho ligand binding and activation	R-HSA-190374	0.582514	0.235	0	0
FLT3 signaling by CBL mutants	R-HSA-9706377	0.582514	0.235	0	0
Defective SLC1A3 causes episodic ataxia 6 (EA6)	R-HSA-5619062	0.582514	0.235	0	0
Defective F9 activation	R-HSA-9673221	0.582514	0.235	0	0
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	0.582514	0.235	0	0
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	0.582514	0.235	0	0
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	0.582514	0.235	0	0
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	0.582514	0.235	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	0.369368	0.433	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	0.447836	0.349	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	0.466356	0.331	0	0
Interleukin receptor SHC signaling	R-HSA-912526	0.488725	0.311	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	0.517386	0.286	0	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	0.517386	0.286	0	0
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	0.517386	0.286	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	0.517386	0.286	0	0
Trafficking of AMPA receptors	R-HSA-399719	0.489914	0.310	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	0.416118	0.381	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	0.435694	0.361	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	0.437954	0.359	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	0.473378	0.325	0	0
SHC-mediated cascade:FGFR1	R-HSA-5654688	0.514883	0.288	0	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	0.558183	0.253	0	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	0.558183	0.253	0	0
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	0.558183	0.253	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	0.491627	0.308	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	0.547084	0.262	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	0.510605	0.292	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	0.540402	0.267	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	0.535807	0.271	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	0.575681	0.240	0	0
MET activates RAS signaling	R-HSA-8851805	0.593085	0.227	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	0.593085	0.227	0	0
Polymerase switching	R-HSA-69091	0.593085	0.227	0	0
Leading Strand Synthesis	R-HSA-69109	0.593085	0.227	0	0
GRB2 events in EGFR signaling	R-HSA-179812	0.593085	0.227	0	0
Viral mRNA Translation	R-HSA-192823	0.559396	0.252	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	0.572596	0.242	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	0.572596	0.242	0	0
HCMV Early Events	R-HSA-9609690	0.589943	0.229	0	0
Negative regulation of MET activity	R-HSA-6807004	0.603119	0.220	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	0.603119	0.220	0	0
Co-inhibition by CTLA4	R-HSA-389513	0.603119	0.220	0	0
Telomere Extension By Telomerase	R-HSA-171319	0.612534	0.213	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	0.612534	0.213	0	0
Formation of the Early Elongation Complex	R-HSA-113418	0.612534	0.213	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	0.612534	0.213	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	0.565217	0.248	0	0
RUNX2 regulates bone development	R-HSA-8941326	0.447836	0.349	0	0
RNA Polymerase III Transcription	R-HSA-74158	0.447836	0.349	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	0.612534	0.213	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	0.407248	0.390	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	0.407248	0.390	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	0.565217	0.248	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	0.295749	0.529	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	0.295749	0.529	0	0
Downstream signal transduction	R-HSA-186763	0.316943	0.499	0	0
Specification of the neural plate border	R-HSA-9834899	0.183641	0.736	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	0.532392	0.274	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	0.532392	0.274	0	0
Formation of definitive endoderm	R-HSA-9823730	0.379426	0.421	0	0
Integrin signaling	R-HSA-354192	0.360445	0.443	0	0
Signaling by PDGFR in disease	R-HSA-9671555	0.434812	0.362	0	0
Signaling by FGFR	R-HSA-190236	0.386976	0.412	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	0.272762	0.564	0	0
Hedgehog 'off' state	R-HSA-5610787	0.413432	0.384	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	0.603119	0.220	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	0.165095	0.782	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	0.165095	0.782	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	0.181456	0.741	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	0.369657	0.432	0	0
p75NTR recruits signalling complexes	R-HSA-209543	0.593085	0.227	0	0
G1/S Transition	R-HSA-69206	0.227222	0.644	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	0.182983	0.738	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	0.165095	0.782	0	0
HSF1-dependent transactivation	R-HSA-3371571	0.454982	0.342	0	0
Polo-like kinase mediated events	R-HSA-156711	0.163171	0.787	0	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	0.486667	0.313	0	0
FGFR1 ligand binding and activation	R-HSA-190242	0.323530	0.490	0	0
Myogenesis	R-HSA-525793	0.369657	0.432	0	0
Signaling by FGFR1	R-HSA-5654736	0.281216	0.551	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	0.491229	0.309	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	0.243404	0.614	0	0
Signaling by ERBB2	R-HSA-1227986	0.344760	0.462	0	0
Frs2-mediated activation	R-HSA-170968	0.165238	0.782	0	0
p75NTR signals via NF-kB	R-HSA-193639	0.422604	0.374	0	0
Signaling by FGFR3	R-HSA-5654741	0.221653	0.654	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	0.190382	0.720	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	0.222269	0.653	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	0.323530	0.490	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	0.207632	0.683	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	0.482186	0.317	0	0
Regulation of the apoptosome activity	R-HSA-9627069	0.482186	0.317	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	0.514883	0.288	0	0
Cytochrome c-mediated apoptotic response	R-HSA-111461	0.558183	0.253	0	0
Signaling by FGFR4	R-HSA-5654743	0.451845	0.345	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	0.417892	0.379	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	0.417892	0.379	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	0.545162	0.263	0	0
Activation of NOXA and translocation to mitochondria	R-HSA-111448	0.172831	0.762	0	0
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	0.190382	0.720	0	0
Regulation of CDH11 function	R-HSA-9762292	0.222269	0.653	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	0.255105	0.593	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	0.354530	0.450	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	0.295749	0.529	0	0
DNA strand elongation	R-HSA-69190	0.338619	0.470	0	0
Nuclear RNA decay	R-HSA-9930044	0.360445	0.443	0	0
Formation of apoptosome	R-HSA-111458	0.482186	0.317	0	0
PI3K/AKT activation	R-HSA-198203	0.482186	0.317	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	0.455031	0.342	0	0
Pyroptosis	R-HSA-5620971	0.612534	0.213	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	0.300748	0.522	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	0.431921	0.365	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	0.513084	0.290	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	0.579715	0.237	0	0
Resolution of D-Loop Structures	R-HSA-5693537	0.558033	0.253	0	0
Generation of second messenger molecules	R-HSA-202433	0.237253	0.625	0	0
Signaling by WNT	R-HSA-195721	0.174046	0.759	0	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	0.172831	0.762	0	0
PKA activation	R-HSA-163615	0.163171	0.787	0	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	0.398630	0.399	0	0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	0.356029	0.449	0	0
Separation of Sister Chromatids	R-HSA-2467813	0.207914	0.682	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	0.383294	0.416	0	0
Orc1 removal from chromatin	R-HSA-68949	0.473378	0.325	0	0
NF-kB is activated and signals survival	R-HSA-209560	0.558183	0.253	0	0
Apoptotic factor-mediated response	R-HSA-111471	0.547084	0.262	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	0.535807	0.271	0	0
Serotonin clearance from the synaptic cleft	R-HSA-380615	0.593085	0.227	0	0
Role of second messengers in netrin-1 signaling	R-HSA-418890	0.593085	0.227	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	0.612534	0.213	0	0
Interleukin-2 signaling	R-HSA-9020558	0.521195	0.283	0	0
S Phase	R-HSA-69242	0.197997	0.703	0	0
Cellular response to heat stress	R-HSA-3371556	0.182886	0.738	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	0.213511	0.671	0	0
Cap-dependent Translation Initiation	R-HSA-72737	0.275429	0.560	0	0
Signal attenuation	R-HSA-74749	0.222269	0.653	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	0.227110	0.644	0	0
Long-term potentiation	R-HSA-9620244	0.345279	0.462	0	0
Eukaryotic Translation Initiation	R-HSA-72613	0.275429	0.560	0	0
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	0.593085	0.227	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	0.590762	0.229	0	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	0.241329	0.617	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	0.570911	0.243	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	0.369657	0.432	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	0.457519	0.340	0	0
Switching of origins to a post-replicative state	R-HSA-69052	0.555544	0.255	0	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	0.345279	0.462	0	0
Prolonged ERK activation events	R-HSA-169893	0.241329	0.617	0	0
Insulin receptor signalling cascade	R-HSA-74751	0.194877	0.710	0	0
Autophagy	R-HSA-9612973	0.265995	0.575	0	0
Sensory perception of sour taste	R-HSA-9729555	0.172831	0.762	0	0
Calcineurin activates NFAT	R-HSA-2025928	0.190382	0.720	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	0.263533	0.579	0	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	0.189616	0.722	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	0.167625	0.776	0	0
Disorders of Developmental Biology	R-HSA-9675151	0.268291	0.571	0	0
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	0.398630	0.399	0	0
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	0.398630	0.399	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	0.218247	0.661	0	0
FGFR1c ligand binding and activation	R-HSA-190373	0.356029	0.449	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	0.254669	0.594	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	0.177699	0.750	0	0
FGFR3 ligand binding and activation	R-HSA-190239	0.422604	0.374	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	0.382348	0.418	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	0.178889	0.747	0	0
Formation of the posterior neural plate	R-HSA-9832991	0.521195	0.283	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	0.431921	0.365	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	0.540402	0.267	0	0
Ca2+ pathway	R-HSA-4086398	0.555544	0.255	0	0
Selective autophagy	R-HSA-9663891	0.328951	0.483	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	0.510605	0.292	0	0
Mitotic Anaphase	R-HSA-68882	0.172736	0.763	0	0
Mitophagy	R-HSA-5205647	0.404258	0.393	0	0
G1 Phase	R-HSA-69236	0.471629	0.326	0	0
Cyclin D associated events in G1	R-HSA-69231	0.471629	0.326	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	0.442475	0.354	0	0
TBC/RABGAPs	R-HSA-8854214	0.451845	0.345	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	0.439965	0.357	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	0.558033	0.253	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	0.579715	0.237	0	0
Signaling by SCF-KIT	R-HSA-1433557	0.192083	0.717	0	0
TNF signaling	R-HSA-75893	0.281216	0.551	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	0.486667	0.313	1	1
Oncogene Induced Senescence	R-HSA-2559585	0.273516	0.563	0	0
Platelet calcium homeostasis	R-HSA-418360	0.442475	0.354	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	0.575207	0.240	0	0
DNA Replication	R-HSA-69306	0.308887	0.510	0	0
Macroautophagy	R-HSA-1632852	0.331596	0.479	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	0.182191	0.739	0	0
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	0.172831	0.762	0	0
Disorders of Nervous System Development	R-HSA-9697154	0.322281	0.492	0	0
Pervasive developmental disorders	R-HSA-9005895	0.322281	0.492	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	0.322281	0.492	0	0
Downregulation of ERBB4 signaling	R-HSA-1253288	0.398630	0.399	0	0
CRMPs in Sema3A signaling	R-HSA-399956	0.389542	0.409	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	0.389542	0.409	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	0.389542	0.409	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	0.422604	0.374	0	0
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	0.482186	0.317	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	0.490688	0.309	0	0
Eukaryotic Translation Termination	R-HSA-72764	0.451701	0.345	0	0
Potassium Channels	R-HSA-1296071	0.575207	0.240	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	0.595590	0.225	0	0
Signalling to ERKs	R-HSA-187687	0.273516	0.563	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	0.241050	0.618	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	0.296945	0.527	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	0.540402	0.267	0	0
Signaling by NODAL	R-HSA-1181150	0.603119	0.220	0	0
Glycogen metabolism	R-HSA-8982491	0.532392	0.274	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	0.414545	0.382	0	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	0.309335	0.510	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	0.254224	0.595	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	0.203313	0.692	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	0.525738	0.279	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	0.600815	0.221	0	0
Membrane Trafficking	R-HSA-199991	0.213800	0.670	0	0
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	0.354530	0.450	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	0.575681	0.240	0	0
DNA Repair	R-HSA-73894	0.268860	0.570	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	0.230864	0.637	0	0
Spry regulation of FGF signaling	R-HSA-1295596	0.422604	0.374	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	0.514883	0.288	0	0
EPH-Ephrin signaling	R-HSA-2682334	0.396705	0.402	0	0
Neuronal System	R-HSA-112316	0.234466	0.630	0	0
Integration of energy metabolism	R-HSA-163685	0.539003	0.268	0	0
MTF1 activates gene expression	R-HSA-5660489	0.172831	0.762	0	0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	0.159810	0.796	0	0
Interleukin-33 signaling	R-HSA-9014843	0.392923	0.406	0	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	0.392923	0.406	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	0.165238	0.782	0	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	0.222269	0.653	0	0
Regulation of KIT signaling	R-HSA-1433559	0.189616	0.722	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	0.163171	0.787	0	0
PKA activation in glucagon signalling	R-HSA-164378	0.163171	0.787	0	0
MET activates STAT3	R-HSA-8875791	0.464146	0.333	0	0
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	0.464146	0.333	0	0
Signaling by LTK	R-HSA-9842663	0.322281	0.492	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	0.398630	0.399	0	0
Notch-HLH transcription pathway	R-HSA-350054	0.273200	0.564	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	0.356029	0.449	0	0
Alanine metabolism	R-HSA-8964540	0.527017	0.278	0	0
Transmission across Electrical Synapses	R-HSA-112307	0.527017	0.278	0	0
Electric Transmission Across Gap Junctions	R-HSA-112303	0.527017	0.278	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	0.527017	0.278	0	0
Smooth Muscle Contraction	R-HSA-445355	0.236045	0.627	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	0.345279	0.462	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	0.345279	0.462	0	0
TGFBR3 expression	R-HSA-9839394	0.345279	0.462	0	0
PLC beta mediated events	R-HSA-112043	0.248379	0.605	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	0.312191	0.506	0	0
ISG15 antiviral mechanism	R-HSA-1169408	0.242799	0.615	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	0.482186	0.317	0	0
Cristae formation	R-HSA-8949613	0.394043	0.404	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	0.434812	0.362	0	0
Reelin signalling pathway	R-HSA-8866376	0.582514	0.235	0	0
Suppression of autophagy	R-HSA-9636569	0.582514	0.235	0	0
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	0.582514	0.235	0	0
Sodium/Calcium exchangers	R-HSA-425561	0.558183	0.253	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	0.491229	0.309	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	0.473878	0.324	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	0.579715	0.237	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	0.377404	0.423	0	0
FLT3 signaling in disease	R-HSA-9682385	0.292710	0.534	0	0
Interleukin-2 family signaling	R-HSA-451927	0.532392	0.274	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	0.565217	0.248	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	0.389542	0.409	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	0.391839	0.407	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	0.189179	0.723	0	0
Regulation of NPAS4 gene transcription	R-HSA-9768777	0.441270	0.355	0	0
Protein methylation	R-HSA-8876725	0.422604	0.374	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	0.306635	0.513	0	0
Deubiquitination	R-HSA-5688426	0.184009	0.735	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	0.393837	0.405	0	0
Signaling by PTK6	R-HSA-8848021	0.393837	0.405	0	0
Activated NTRK2 signals through FYN	R-HSA-9032500	0.398630	0.399	0	0
TRP channels	R-HSA-3295583	0.369657	0.432	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	0.482186	0.317	0	0
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	0.486667	0.313	0	0
Diseases associated with surfactant metabolism	R-HSA-5687613	0.593085	0.227	0	0
L1CAM interactions	R-HSA-373760	0.455815	0.341	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	0.360445	0.443	0	0
Opioid Signalling	R-HSA-111885	0.274317	0.562	0	0
MHC class II antigen presentation	R-HSA-2132295	0.541545	0.266	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	0.300748	0.522	0	0
Negative regulation of FLT3	R-HSA-9706369	0.455031	0.342	0	0
Interleukin-1 family signaling	R-HSA-446652	0.299191	0.524	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	0.236227	0.627	0	0
Nef and signal transduction	R-HSA-164944	0.309335	0.510	0	0
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	0.354530	0.450	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	0.354530	0.450	0	0
CHL1 interactions	R-HSA-447041	0.354530	0.450	0	0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	0.398630	0.399	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	0.356029	0.449	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	0.236227	0.627	0	0
Carnitine shuttle	R-HSA-200425	0.296945	0.527	0	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	0.441270	0.355	0	0
Protein hydroxylation	R-HSA-9629569	0.379426	0.421	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	0.233277	0.632	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	0.442475	0.354	0	0
G-protein mediated events	R-HSA-112040	0.336894	0.473	0	0
EPHB-mediated forward signaling	R-HSA-3928662	0.325292	0.488	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	0.482186	0.317	0	0
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	0.441270	0.355	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	0.547084	0.262	0	0
Cardiogenesis	R-HSA-9733709	0.535807	0.271	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	0.163171	0.787	0	0
Kidney development	R-HSA-9830369	0.336894	0.473	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	0.493035	0.307	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	0.517386	0.286	0	0
Signaling by TGFBR3	R-HSA-9839373	0.510605	0.292	0	0
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	0.172831	0.762	0	0
DSCAM interactions	R-HSA-376172	0.392923	0.406	0	0
CASP5-mediated substrate cleavage	R-HSA-9960525	0.464146	0.333	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	0.227110	0.644	0	0
Alpha-defensins	R-HSA-1462054	0.398630	0.399	0	0
Maturation of nucleoprotein	R-HSA-9683610	0.356029	0.449	0	0
Syndecan interactions	R-HSA-3000170	0.296945	0.527	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	0.254224	0.595	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	0.321007	0.493	0	0
ARMS-mediated activation	R-HSA-170984	0.441270	0.355	0	0
TNFR1-mediated ceramide production	R-HSA-5626978	0.527017	0.278	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	0.362099	0.441	0	0
Synthesis of PI	R-HSA-1483226	0.521195	0.283	0	0
PTK6 Down-Regulation	R-HSA-8849472	0.582514	0.235	0	0
Interleukin-36 pathway	R-HSA-9014826	0.582514	0.235	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	0.610298	0.214	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	0.283055	0.548	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	0.272762	0.564	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	0.352241	0.453	0	0
Co-stimulation by CD28	R-HSA-389356	0.167786	0.775	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	0.237253	0.625	0	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	0.213511	0.671	0	0
Sensory processing of sound	R-HSA-9659379	0.522859	0.282	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	0.190382	0.720	0	0
Cell-extracellular matrix interactions	R-HSA-446353	0.215042	0.667	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	0.204577	0.689	0	0
Co-inhibition by PD-1	R-HSA-389948	0.550789	0.259	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	0.308969	0.510	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	0.441270	0.355	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	0.360445	0.443	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	0.475944	0.322	0	0
Selenocysteine synthesis	R-HSA-2408557	0.533054	0.273	0	0
The NLRP3 inflammasome	R-HSA-844456	0.575681	0.240	0	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	0.422604	0.374	0	0
Signal transduction by L1	R-HSA-445144	0.603119	0.220	0	0
Formation of the anterior neural plate	R-HSA-9823739	0.422604	0.374	0	0
Signaling by ALK	R-HSA-201556	0.351785	0.454	0	0
Glycolysis	R-HSA-70171	0.413432	0.384	0	0
Cation-coupled Chloride cotransporters	R-HSA-426117	0.354530	0.450	0	0
CASP4-mediated substrate cleavage	R-HSA-9960519	0.464146	0.333	0	0
Adrenoceptors	R-HSA-390696	0.398630	0.399	0	0
Sodium/Proton exchangers	R-HSA-425986	0.398630	0.399	0	0
Dopamine receptors	R-HSA-390651	0.527017	0.278	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	0.371782	0.430	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	0.391839	0.407	0	0
NrCAM interactions	R-HSA-447038	0.582514	0.235	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	0.405298	0.392	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	0.488725	0.311	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	0.572362	0.242	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	0.592044	0.228	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	0.478467	0.320	0	0
Interleukin-7 signaling	R-HSA-1266695	0.345279	0.462	0	0
HDL assembly	R-HSA-8963896	0.189616	0.722	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	0.389542	0.409	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	0.417892	0.379	0	0
Regulation of CDH11 gene transcription	R-HSA-9762293	0.441270	0.355	0	0
Integration of provirus	R-HSA-162592	0.558183	0.253	0	0
PTEN Regulation	R-HSA-6807070	0.481659	0.317	0	0
Maturation of nucleoprotein	R-HSA-9694631	0.575681	0.240	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	0.473531	0.325	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	0.422604	0.374	0	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	0.521195	0.283	0	0
Toxicity of botulinum toxin type C (botC)	R-HSA-5250971	0.582514	0.235	0	0
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	0.558183	0.253	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	0.510605	0.292	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	0.393759	0.405	0	0
Interleukin-15 signaling	R-HSA-8983432	0.593085	0.227	0	0
Glucose metabolism	R-HSA-70326	0.567464	0.246	0	0
CD28 dependent Vav1 pathway	R-HSA-389359	0.356029	0.449	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	0.389542	0.409	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	0.351785	0.454	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	0.558033	0.253	0	0
Specification of primordial germ cells	R-HSA-9827857	0.517386	0.286	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	0.434812	0.362	0	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	0.558183	0.253	0	0
Regulation of beta-cell development	R-HSA-186712	0.596291	0.225	0	0
Signaling by Leptin	R-HSA-2586552	0.482186	0.317	0	0
Plasma lipoprotein assembly	R-HSA-8963898	0.514883	0.288	0	0
STING mediated induction of host immune responses	R-HSA-1834941	0.575681	0.240	0	0
Gene Silencing by RNA	R-HSA-211000	0.169047	0.772	0	0
Signaling by Insulin receptor	R-HSA-74752	0.618980	0.208	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	0.620249	0.207	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	0.621302	0.207	0	0
Triglyceride catabolism	R-HSA-163560	0.621302	0.207	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	0.625883	0.204	0	0
Processing of SMDT1	R-HSA-8949664	0.625883	0.204	0	0
Reversible hydration of carbon dioxide	R-HSA-1475029	0.625883	0.204	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	0.625883	0.204	0	0
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	0.625883	0.204	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	0.626704	0.203	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	0.628734	0.202	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	0.628734	0.202	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	0.629357	0.201	0	0
Signalling to RAS	R-HSA-167044	0.629357	0.201	0	0
RMTs methylate histone arginines	R-HSA-3214858	0.629488	0.201	0	0
Transmission across Chemical Synapses	R-HSA-112315	0.630220	0.201	0	0
Cam-PDE 1 activation	R-HSA-111957	0.631503	0.200	0	0
PKB-mediated events	R-HSA-109703	0.631503	0.200	0	0
PTK6 Regulates Cell Cycle	R-HSA-8849470	0.631503	0.200	0	0
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	0.631503	0.200	0	0
PDE3B signalling	R-HSA-165160	0.631503	0.200	0	0
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	0.631503	0.200	0	0
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	0.631503	0.200	0	0
Signaling by MAPK mutants	R-HSA-9652817	0.631503	0.200	0	0
Defective CSF2RA causes SMDP4	R-HSA-5688890	0.631503	0.200	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	0.631503	0.200	0	0
Signaling by RNF43 mutants	R-HSA-5340588	0.631503	0.200	0	0
Defective CSF2RB causes SMDP5	R-HSA-5688849	0.631503	0.200	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	0.631503	0.200	0	0
Phosphorylation of Emi1	R-HSA-176417	0.631503	0.200	0	0
Formation of the Editosome	R-HSA-75094	0.631503	0.200	0	0
CDC6 association with the ORC:origin complex	R-HSA-68689	0.631503	0.200	0	0
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	0.631503	0.200	0	0
Signalling to p38 via RIT and RIN	R-HSA-187706	0.631503	0.200	0	0
Release of apoptotic factors from the mitochondria	R-HSA-111457	0.631503	0.200	0	0
Acetylcholine inhibits contraction of outer hair cells	R-HSA-9667769	0.631503	0.200	0	0
CLEC7A/inflammasome pathway	R-HSA-5660668	0.631503	0.200	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	0.631503	0.200	0	0
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	0.631503	0.200	0	0
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	0.631503	0.200	0	0
Stimuli-sensing channels	R-HSA-2672351	0.634724	0.197	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	0.634958	0.197	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	0.634958	0.197	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	0.634958	0.197	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	0.637168	0.196	1	1
Golgi Associated Vesicle Biogenesis	R-HSA-432722	0.637168	0.196	0	0
Voltage gated Potassium channels	R-HSA-1296072	0.641148	0.193	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	0.641148	0.193	0	0
Ovarian tumor domain proteases	R-HSA-5689896	0.641148	0.193	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	0.644003	0.191	0	0
tRNA processing in the nucleus	R-HSA-6784531	0.644408	0.191	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	0.647439	0.189	0	0
PI Metabolism	R-HSA-1483255	0.651817	0.186	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	0.653647	0.185	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	0.654369	0.184	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	0.654369	0.184	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	0.654369	0.184	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	0.656523	0.183	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	0.656523	0.183	0	0
DAP12 signaling	R-HSA-2424491	0.656523	0.183	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	0.656523	0.183	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	0.656590	0.183	0	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	0.656590	0.183	0	0
FGFR3c ligand binding and activation	R-HSA-190372	0.656590	0.183	0	0
Physiological factors	R-HSA-5578768	0.656590	0.183	0	0
cGMP effects	R-HSA-418457	0.656590	0.183	0	0
Signal regulatory protein family interactions	R-HSA-391160	0.656590	0.183	0	0
Signaling by MET	R-HSA-6806834	0.657778	0.182	0	0
Signaling by FGFR2	R-HSA-5654738	0.657778	0.182	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	0.657778	0.182	0	0
TCR signaling	R-HSA-202403	0.658344	0.182	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	0.658344	0.182	0	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	0.658344	0.182	0	0
Metabolism of RNA	R-HSA-8953854	0.660866	0.180	0	0
Influenza Infection	R-HSA-168255	0.662411	0.179	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	0.665566	0.177	0	0
Ion transport by P-type ATPases	R-HSA-936837	0.674592	0.171	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	0.674746	0.171	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	0.674746	0.171	0	0
STAT5 Activation	R-HSA-9645135	0.674746	0.171	0	0
Erythropoietin activates STAT5	R-HSA-9027283	0.674746	0.171	0	0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors	R-HSA-629587	0.674746	0.171	0	0
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	0.674746	0.171	0	0
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	0.674746	0.171	0	0
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	0.674746	0.171	0	0
MET Receptor Activation	R-HSA-6806942	0.674746	0.171	0	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	0.674746	0.171	0	0
Neurofascin interactions	R-HSA-447043	0.674746	0.171	0	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	0.674746	0.171	0	0
NADPH regeneration	R-HSA-389542	0.674746	0.171	0	0
HDL clearance	R-HSA-8964011	0.674746	0.171	0	0
Lipid particle organization	R-HSA-8964572	0.674746	0.171	0	0
FRS-mediated FGFR4 signaling	R-HSA-5654712	0.678146	0.169	0	0
FGFR2 alternative splicing	R-HSA-6803529	0.678146	0.169	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	0.678146	0.169	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	0.678146	0.169	0	0
Ethanol oxidation	R-HSA-71384	0.678146	0.169	0	0
Recycling pathway of L1	R-HSA-437239	0.681712	0.166	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	0.681712	0.166	0	0
HCMV Late Events	R-HSA-9610379	0.682712	0.166	0	0
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	0.685244	0.164	0	0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	0.685244	0.164	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	0.685244	0.164	0	0
SHC1 events in EGFR signaling	R-HSA-180336	0.685244	0.164	0	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	0.685244	0.164	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	0.685244	0.164	0	0
Telomere C-strand synthesis initiation	R-HSA-174430	0.685244	0.164	0	0
p38MAPK events	R-HSA-171007	0.685244	0.164	0	0
Lysosphingolipid and LPA receptors	R-HSA-419408	0.685244	0.164	0	0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	0.685244	0.164	0	0
Cilium Assembly	R-HSA-5617833	0.685591	0.164	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	0.686393	0.163	0	0
Potential therapeutics for SARS	R-HSA-9679191	0.696458	0.157	0	0
GPER1 signaling	R-HSA-9634597	0.698011	0.156	0	0
Metal ion SLC transporters	R-HSA-425410	0.698011	0.156	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	0.698499	0.156	0	0
Formation of the ureteric bud	R-HSA-9830674	0.700687	0.154	0	0
SARS-CoV-1 Infection	R-HSA-9678108	0.701730	0.154	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	0.702995	0.153	0	0
Killing mechanisms	R-HSA-9664420	0.711905	0.148	0	0
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	0.711905	0.148	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	0.711905	0.148	0	0
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	0.711905	0.148	0	0
Regulation of BACH1 activity	R-HSA-9708530	0.711905	0.148	0	0
Regulation of NF-kappa B signaling	R-HSA-9758274	0.711905	0.148	0	0
Serotonin and melatonin biosynthesis	R-HSA-209931	0.711905	0.148	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	0.712916	0.147	0	0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	0.712916	0.147	0	0
Disinhibition of SNARE formation	R-HSA-114516	0.712916	0.147	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	0.712916	0.147	0	0
FGFR3b ligand binding and activation	R-HSA-190371	0.712916	0.147	0	0
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	0.712916	0.147	0	0
DAG1 core M1 glycosylations	R-HSA-8932506	0.712916	0.147	0	0
mRNA Editing: C to U Conversion	R-HSA-72200	0.712916	0.147	0	0
PTK6 Expression	R-HSA-8849473	0.712916	0.147	0	0
Activated NTRK2 signals through CDK5	R-HSA-9032845	0.712916	0.147	0	0
Ca2+ activated K+ channels	R-HSA-1296052	0.712916	0.147	0	0
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	0.712916	0.147	0	0
Glycoprotein hormones	R-HSA-209822	0.712916	0.147	0	0
Phase 3 - rapid repolarisation	R-HSA-5576890	0.712916	0.147	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	0.712916	0.147	0	0
DNA Damage Bypass	R-HSA-73893	0.713741	0.146	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	0.715936	0.145	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	0.722005	0.141	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	0.728898	0.137	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	0.730226	0.137	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	0.730226	0.137	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	0.730226	0.137	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	0.736645	0.133	0	0
Phase 2 - plateau phase	R-HSA-5576893	0.736645	0.133	0	0
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	0.736645	0.133	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	0.736645	0.133	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	0.736645	0.133	0	0
Coenzyme A biosynthesis	R-HSA-196783	0.736645	0.133	0	0
Synthesis of PG	R-HSA-1483148	0.736645	0.133	0	0
Response to metal ions	R-HSA-5660526	0.736645	0.133	0	0
Host Interactions of HIV factors	R-HSA-162909	0.737233	0.132	0	0
Interleukin-1 signaling	R-HSA-9020702	0.738560	0.132	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	0.739902	0.131	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	0.742120	0.130	0	0
Acyl chain remodelling of PS	R-HSA-1482801	0.742120	0.130	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	0.742637	0.129	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	0.742637	0.129	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	0.742637	0.129	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	0.742637	0.129	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	0.742637	0.129	0	0
DAG1 core M2 glycosylations	R-HSA-8932504	0.746609	0.127	0	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	0.746609	0.127	0	0
Myoclonic epilepsy of Lafora	R-HSA-3785653	0.746609	0.127	0	0
Activated NTRK2 signals through PI3K	R-HSA-9028335	0.746609	0.127	0	0
Activation of RAS in B cells	R-HSA-1169092	0.746609	0.127	0	0
Formation of annular gap junctions	R-HSA-196025	0.746609	0.127	0	0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	0.746609	0.127	0	0
Axonal growth inhibition (RHOA activation)	R-HSA-193634	0.746609	0.127	0	0
Regulation by c-FLIP	R-HSA-3371378	0.746609	0.127	0	0
Dimerization of procaspase-8	R-HSA-69416	0.746609	0.127	0	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	0.746609	0.127	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	0.746609	0.127	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	0.749551	0.125	0	0
Signaling by NOTCH	R-HSA-157118	0.752478	0.124	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	0.755234	0.122	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	0.759549	0.119	0	0
Regulation of NPAS4 gene expression	R-HSA-9768759	0.759549	0.119	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	0.759549	0.119	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	0.759549	0.119	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	0.759549	0.119	0	0
Gastrulation	R-HSA-9758941	0.763612	0.117	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	0.766858	0.115	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	0.767420	0.115	0	0
Defects in vitamin and cofactor metabolism	R-HSA-3296482	0.767420	0.115	0	0
Signaling by PDGF	R-HSA-186797	0.768413	0.114	0	0
Heme signaling	R-HSA-9707616	0.768413	0.114	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	0.769102	0.114	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	0.769102	0.114	0	0
Proteasome assembly	R-HSA-9907900	0.775377	0.110	0	0
Interleukin-21 signaling	R-HSA-9020958	0.776349	0.110	0	0
Gap junction degradation	R-HSA-190873	0.776349	0.110	0	0
WNT mediated activation of DVL	R-HSA-201688	0.776349	0.110	0	0
CASP8 activity is inhibited	R-HSA-5218900	0.776349	0.110	0	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	0.776349	0.110	0	0
p75NTR regulates axonogenesis	R-HSA-193697	0.776349	0.110	0	0
Regulation of signaling by NODAL	R-HSA-1433617	0.776349	0.110	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	0.776349	0.110	0	0
mRNA Editing	R-HSA-75072	0.776349	0.110	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	0.776349	0.110	0	0
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	0.776349	0.110	0	0
Respiratory syncytial virus genome replication	R-HSA-9834752	0.776349	0.110	0	0
COPI-mediated anterograde transport	R-HSA-6807878	0.777979	0.109	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	0.778852	0.109	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	0.778852	0.109	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	0.778852	0.109	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	0.778852	0.109	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	0.778852	0.109	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	0.780706	0.108	0	0
Mismatch Repair	R-HSA-5358508	0.780706	0.108	0	0
Tie2 Signaling	R-HSA-210993	0.780706	0.108	0	0
Nephron development	R-HSA-9831926	0.780706	0.108	0	0
Platelet sensitization by LDL	R-HSA-432142	0.780706	0.108	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	0.782867	0.106	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	0.787686	0.104	0	0
Neutrophil degranulation	R-HSA-6798695	0.787991	0.103	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	0.789071	0.103	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	0.789071	0.103	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	0.789071	0.103	0	0
FRS-mediated FGFR2 signaling	R-HSA-5654700	0.795539	0.099	0	0
HIV elongation arrest and recovery	R-HSA-167287	0.795539	0.099	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	0.795539	0.099	0	0
Inflammasomes	R-HSA-622312	0.795539	0.099	0	0
SLC-mediated transport of organic cations	R-HSA-549127	0.797486	0.098	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	0.798448	0.098	0	0
Regulation of signaling by CBL	R-HSA-912631	0.800210	0.097	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	0.800210	0.097	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	0.800210	0.097	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	0.800210	0.097	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	0.802105	0.096	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	0.802105	0.096	0	0
Diseases of DNA repair	R-HSA-9675135	0.802105	0.096	0	0
Metabolism of serotonin	R-HSA-380612	0.802601	0.096	0	0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	0.802601	0.096	0	0
Formation of intermediate mesoderm	R-HSA-9761174	0.802601	0.096	0	0
Arachidonate production from DAG	R-HSA-426048	0.802601	0.096	0	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	0.802601	0.096	0	0
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	0.802601	0.096	0	0
Pexophagy	R-HSA-9664873	0.802601	0.096	0	0
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	0.802601	0.096	0	0
Maturation of spike protein	R-HSA-9683686	0.802601	0.096	0	0
Defective factor IX causes hemophilia B	R-HSA-9668250	0.802601	0.096	0	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	0.802601	0.096	0	0
Peptide hormone biosynthesis	R-HSA-209952	0.802601	0.096	0	0
Metal sequestration by antimicrobial proteins	R-HSA-6799990	0.802601	0.096	0	0
Synthesis of DNA	R-HSA-69239	0.805839	0.094	0	0
Signaling by Hedgehog	R-HSA-5358351	0.807660	0.093	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	0.810772	0.091	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	0.810772	0.091	0	0
Late endosomal microautophagy	R-HSA-9615710	0.811161	0.091	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	0.811300	0.091	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	0.814493	0.089	0	0
Adipogenesis	R-HSA-9843745	0.814530	0.089	0	0
Nephrin family interactions	R-HSA-373753	0.818159	0.087	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	0.818159	0.087	0	0
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	0.818159	0.087	0	0
Signaling by NOTCH1	R-HSA-1980143	0.820634	0.086	0	0
Signaling by Interleukins	R-HSA-449147	0.820673	0.086	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	0.822878	0.085	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	0.823451	0.084	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	0.824333	0.084	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	0.824333	0.084	0	0
Stabilization of p53	R-HSA-69541	0.824333	0.084	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	0.825760	0.083	0	0
Neurotransmitter clearance	R-HSA-112311	0.825760	0.083	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	0.825760	0.083	0	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	0.825772	0.083	0	0
DAG1 core M3 glycosylations	R-HSA-8932505	0.825772	0.083	0	0
FGFR2b ligand binding and activation	R-HSA-190377	0.825772	0.083	0	0
Activated NTRK3 signals through RAS	R-HSA-9034864	0.825772	0.083	0	0
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	0.825772	0.083	0	0
RHOBTB3 ATPase cycle	R-HSA-9706019	0.825772	0.083	0	0
Bicarbonate transporters	R-HSA-425381	0.825772	0.083	0	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	0.825772	0.083	0	0
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	0.825772	0.083	0	0
SARS-CoV-2 modulates autophagy	R-HSA-9754560	0.825772	0.083	0	0
Synthesis of PIPs at the ER membrane	R-HSA-1483248	0.825772	0.083	0	0
PECAM1 interactions	R-HSA-210990	0.825772	0.083	0	0
Prostanoid ligand receptors	R-HSA-391908	0.825772	0.083	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	0.826253	0.083	0	0
Adaptive Immune System	R-HSA-1280218	0.829298	0.081	0	0
Cellular response to starvation	R-HSA-9711097	0.830221	0.081	0	0
Regulated Necrosis	R-HSA-5218859	0.834282	0.079	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	0.834649	0.078	0	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	0.834649	0.078	0	0
Lagging Strand Synthesis	R-HSA-69186	0.834649	0.078	0	0
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	0.834649	0.078	0	0
ERK/MAPK targets	R-HSA-198753	0.834649	0.078	0	0
Basigin interactions	R-HSA-210991	0.834649	0.078	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	0.834649	0.078	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	0.835827	0.078	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	0.836611	0.077	0	0
HIV Transcription Elongation	R-HSA-167169	0.836611	0.077	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	0.836611	0.077	0	0
Aggrephagy	R-HSA-9646399	0.836611	0.077	0	0
Attenuation phase	R-HSA-3371568	0.836611	0.077	0	0
Diseases of Immune System	R-HSA-5260271	0.836611	0.077	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	0.836611	0.077	0	0
Developmental Cell Lineages	R-HSA-9734767	0.838000	0.077	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	0.839382	0.076	0	0
Extension of Telomeres	R-HSA-180786	0.840031	0.076	0	0
Triglyceride metabolism	R-HSA-8979227	0.840031	0.076	0	0
Vesicle-mediated transport	R-HSA-5653656	0.841954	0.075	0	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	0.846225	0.073	0	0
Synthesis of diphthamide-EEF2	R-HSA-5358493	0.846225	0.073	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	0.846225	0.073	0	0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	0.846225	0.073	0	0
Presynaptic nicotinic acetylcholine receptors	R-HSA-622323	0.846225	0.073	0	0
Activated NTRK2 signals through RAS	R-HSA-9026519	0.846225	0.073	0	0
ERKs are inactivated	R-HSA-202670	0.846225	0.073	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	0.846225	0.073	0	0
FMO oxidises nucleophiles	R-HSA-217271	0.846225	0.073	0	0
Reduction of cytosolic Ca++ levels	R-HSA-418359	0.846225	0.073	0	0
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	0.846225	0.073	0	0
Proton-coupled monocarboxylate transport	R-HSA-433692	0.846225	0.073	0	0
Uptake of dietary cobalamins into enterocytes	R-HSA-9758881	0.846225	0.073	0	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	0.846225	0.073	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	0.848163	0.072	0	0
SHC-mediated cascade:FGFR4	R-HSA-5654719	0.849774	0.071	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	0.849774	0.071	0	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	0.849774	0.071	0	0
Molybdenum cofactor biosynthesis	R-HSA-947581	0.849774	0.071	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	0.849774	0.071	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	0.852073	0.070	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	0.855505	0.068	0	0
Aquaporin-mediated transport	R-HSA-445717	0.858934	0.066	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	0.859016	0.066	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	0.859016	0.066	0	0
Translation of Structural Proteins	R-HSA-9683701	0.859016	0.066	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	0.859639	0.066	0	0
Ion channel transport	R-HSA-983712	0.860858	0.065	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	0.860933	0.065	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	0.861146	0.065	1	0
Regulation of mitotic cell cycle	R-HSA-453276	0.861146	0.065	1	0
Hedgehog 'on' state	R-HSA-5632684	0.861146	0.065	0	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	0.863628	0.064	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	0.863628	0.064	0	0
Signaling by KIT in disease	R-HSA-9669938	0.863628	0.064	0	0
WNT ligand biogenesis and trafficking	R-HSA-3238698	0.863628	0.064	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	0.863628	0.064	0	0
Regulation of necroptotic cell death	R-HSA-5675482	0.863880	0.064	0	0
Defective EXT2 causes exostoses 2	R-HSA-3656237	0.864277	0.063	0	0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	R-HSA-3656253	0.864277	0.063	0	0
Scavenging by Class F Receptors	R-HSA-3000484	0.864277	0.063	0	0
VLDLR internalisation and degradation	R-HSA-8866427	0.864277	0.063	0	0
SHC-related events triggered by IGF1R	R-HSA-2428933	0.864277	0.063	0	0
Trafficking and processing of endosomal TLR	R-HSA-1679131	0.864277	0.063	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	0.864277	0.063	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	0.864277	0.063	0	0
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	0.864277	0.063	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	0.864277	0.063	0	0
Estrogen biosynthesis	R-HSA-193144	0.864277	0.063	0	0
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	0.864277	0.063	0	0
OAS antiviral response	R-HSA-8983711	0.864277	0.063	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	0.867359	0.062	0	0
Neurotransmitter release cycle	R-HSA-112310	0.867442	0.062	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	0.867672	0.062	0	0
Ribosome-associated quality control	R-HSA-9948299	0.868040	0.061	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	0.871052	0.060	0	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	0.871052	0.060	0	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	0.871052	0.060	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	0.872464	0.059	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	0.872464	0.059	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	0.874850	0.058	0	0
Miscellaneous transport and binding events	R-HSA-5223345	0.874850	0.058	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	0.876301	0.057	0	0
Growth hormone receptor signaling	R-HSA-982772	0.876301	0.057	0	0
HIV Life Cycle	R-HSA-162587	0.877433	0.057	0	0
FGFR2c ligand binding and activation	R-HSA-190375	0.880212	0.055	0	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	0.880212	0.055	0	0
Postsynaptic nicotinic acetylcholine receptors	R-HSA-622327	0.880212	0.055	0	0
FGFR4 ligand binding and activation	R-HSA-190322	0.880212	0.055	0	0
Acetylcholine binding and downstream events	R-HSA-181431	0.880212	0.055	0	0
Chylomicron remodeling	R-HSA-8963901	0.880212	0.055	0	0
Mtb iron assimilation by chelation	R-HSA-1222449	0.880212	0.055	0	0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	0.880212	0.055	0	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	0.880212	0.055	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	0.880212	0.055	0	0
rRNA modification in the mitochondrion	R-HSA-6793080	0.880212	0.055	0	0
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	0.880212	0.055	0	0
Platelet Adhesion to exposed collagen	R-HSA-75892	0.880212	0.055	0	0
Interleukin-6 signaling	R-HSA-1059683	0.880212	0.055	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	0.881036	0.055	0	0
SLC transporter disorders	R-HSA-5619102	0.881867	0.055	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	0.883799	0.054	0	0
Dual Incision in GG-NER	R-HSA-5696400	0.885028	0.053	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	0.885028	0.053	0	0
RA biosynthesis pathway	R-HSA-5365859	0.885028	0.053	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	0.885768	0.053	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	0.887026	0.052	0	0
Interferon gamma signaling	R-HSA-877300	0.887548	0.052	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	0.887677	0.052	0	0
DAP12 interactions	R-HSA-2172127	0.887677	0.052	0	0
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	0.887879	0.052	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	0.887879	0.052	0	0
TNFs bind their physiological receptors	R-HSA-5669034	0.887879	0.052	0	0
Mitochondrial biogenesis	R-HSA-1592230	0.890115	0.051	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	0.891219	0.050	0	0
Signaling by TGFB family members	R-HSA-9006936	0.892350	0.049	0	0
Removal of the Flap Intermediate	R-HSA-69166	0.894276	0.049	0	0
Retrograde neurotrophin signalling	R-HSA-177504	0.894276	0.049	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	0.894276	0.049	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	0.894276	0.049	0	0
Malate-aspartate shuttle	R-HSA-9856872	0.894276	0.049	0	0
Respiratory syncytial virus genome transcription	R-HSA-9828642	0.894276	0.049	0	0
Non-canonical inflammasome activation	R-HSA-9686114	0.894276	0.049	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	0.894460	0.048	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	0.894799	0.048	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	0.895887	0.048	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	0.896030	0.048	0	0
HCMV Infection	R-HSA-9609646	0.897471	0.047	0	0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	0.898444	0.047	0	0
Activation of G protein gated Potassium channels	R-HSA-1296041	0.898444	0.047	0	0
G protein gated Potassium channels	R-HSA-1296059	0.898444	0.047	0	0
Laminin interactions	R-HSA-3000157	0.898444	0.047	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	0.898567	0.046	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	0.900786	0.045	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	0.903191	0.044	0	0
HSF1 activation	R-HSA-3371511	0.903191	0.044	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	0.903191	0.044	0	0
Glycosphingolipid transport	R-HSA-9845576	0.903191	0.044	0	0
GPVI-mediated activation cascade	R-HSA-114604	0.903191	0.044	0	0
Inositol phosphate metabolism	R-HSA-1483249	0.903529	0.044	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	0.904203	0.044	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	0.904854	0.043	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	0.905958	0.043	0	0
RNA Polymerase III Chain Elongation	R-HSA-73780	0.906690	0.043	0	0
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	0.906690	0.043	0	0
Processive synthesis on the lagging strand	R-HSA-69183	0.906690	0.043	0	0
Translesion synthesis by REV1	R-HSA-110312	0.906690	0.043	0	0
Signaling by Activin	R-HSA-1502540	0.906690	0.043	0	0
Dopamine clearance from the synaptic cleft	R-HSA-379401	0.906690	0.043	0	0
DNA Damage Reversal	R-HSA-73942	0.906690	0.043	0	0
MET activates PTK2 signaling	R-HSA-8874081	0.908075	0.042	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	0.908075	0.042	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	0.908075	0.042	0	0
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	0.908075	0.042	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	0.908565	0.042	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	0.910795	0.041	0	0
Toll-like Receptor Cascades	R-HSA-168898	0.910865	0.041	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	0.911100	0.040	0	0
Transcription of the HIV genome	R-HSA-167172	0.911100	0.040	0	0
HIV Infection	R-HSA-162906	0.912275	0.040	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	0.915883	0.038	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	0.916553	0.038	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	0.916845	0.038	0	0
SHC-mediated cascade:FGFR2	R-HSA-5654699	0.916845	0.038	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	0.916845	0.038	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	0.916845	0.038	0	0
Signaling by BMP	R-HSA-201451	0.916845	0.038	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	0.916845	0.038	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	0.916988	0.038	0	0
Translesion synthesis by POLI	R-HSA-5656121	0.917647	0.037	0	0
Defective GALNT3 causes HFTC	R-HSA-5083625	0.917647	0.037	0	0
Defective GALNT12 causes CRCS1	R-HSA-5083636	0.917647	0.037	0	0
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	0.917647	0.037	0	0
Fructose catabolism	R-HSA-70350	0.917647	0.037	0	0
Induction of Cell-Cell Fusion	R-HSA-9733458	0.917647	0.037	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	0.918720	0.037	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	0.919585	0.036	0	0
Degradation of CDH1	R-HSA-9766229	0.924210	0.034	0	0
Gap junction trafficking and regulation	R-HSA-157858	0.924210	0.034	0	0
Chemokine receptors bind chemokines	R-HSA-380108	0.924210	0.034	0	0
Regulation of insulin secretion	R-HSA-422356	0.925319	0.034	0	0
Signaling by Retinoic Acid	R-HSA-5362517	0.925331	0.034	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	0.925599	0.034	0	0
G beta:gamma signalling through CDC42	R-HSA-8964616	0.927318	0.033	0	0
Translesion synthesis by POLK	R-HSA-5655862	0.927318	0.033	0	0
Defective B4GALT7 causes EDS, progeroid type	R-HSA-3560783	0.927318	0.033	0	0
Defective B3GALT6 causes EDSP2 and SEMDJL1	R-HSA-4420332	0.927318	0.033	0	0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	0.927318	0.033	0	0
SHC1 events in ERBB4 signaling	R-HSA-1250347	0.927318	0.033	0	0
Biosynthesis of maresin-like SPMs	R-HSA-9027307	0.927318	0.033	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	0.927318	0.033	0	0
Passive transport by Aquaporins	R-HSA-432047	0.927318	0.033	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	0.927318	0.033	0	0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	0.927318	0.033	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	0.927750	0.033	0	0
Regulation of RAS by GAPs	R-HSA-5658442	0.930086	0.031	0	0
Cellular responses to stress	R-HSA-2262752	0.930653	0.031	0	0
MAP kinase activation	R-HSA-450294	0.930710	0.031	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	0.931941	0.031	0	0
mRNA Capping	R-HSA-72086	0.932076	0.031	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	0.932076	0.031	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	0.932076	0.031	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	0.935547	0.029	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	0.935740	0.029	0	0
Defective B3GAT3 causes JDSSDHD	R-HSA-3560801	0.935853	0.029	0	0
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	0.935853	0.029	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	0.935853	0.029	0	0
Glycogen storage diseases	R-HSA-3229121	0.935853	0.029	0	0
Catecholamine biosynthesis	R-HSA-209905	0.935853	0.029	0	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	0.935853	0.029	0	0
Choline catabolism	R-HSA-6798163	0.935853	0.029	0	0
Maturation of spike protein	R-HSA-9694548	0.937781	0.028	0	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	0.937781	0.028	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	0.937781	0.028	0	0
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	0.938662	0.027	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	0.940440	0.027	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	0.940618	0.027	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	0.940618	0.027	0	0
Cellular responses to stimuli	R-HSA-8953897	0.941250	0.026	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	0.941434	0.026	0	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	0.941434	0.026	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	0.942474	0.026	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	0.943155	0.025	0	0
HIV Transcription Initiation	R-HSA-167161	0.943155	0.025	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	0.943155	0.025	0	0
Activated point mutants of FGFR2	R-HSA-2033519	0.943387	0.025	0	0
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	0.943387	0.025	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	0.943387	0.025	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	0.944639	0.025	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	0.944639	0.025	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	0.944639	0.025	0	0
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	0.944639	0.025	0	0
Aspartate and asparagine metabolism	R-HSA-8963693	0.944639	0.025	0	0
Amino acids regulate mTORC1	R-HSA-9639288	0.945323	0.024	0	0
Nucleotide biosynthesis	R-HSA-8956320	0.945323	0.024	0	0
Mitochondrial protein degradation	R-HSA-9837999	0.945813	0.024	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	0.949052	0.023	0	0
Interleukin-12 signaling	R-HSA-9020591	0.949447	0.023	0	0
Translesion Synthesis by POLH	R-HSA-110320	0.950036	0.022	0	0
Pyrimidine biosynthesis	R-HSA-500753	0.950036	0.022	0	0
Diseases of hemostasis	R-HSA-9671793	0.950036	0.022	0	0
Other interleukin signaling	R-HSA-449836	0.950036	0.022	0	0
Inwardly rectifying K+ channels	R-HSA-1296065	0.950058	0.022	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	0.950804	0.022	0	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	0.950804	0.022	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	0.952632	0.021	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	0.952632	0.021	0	0
Translation of Structural Proteins	R-HSA-9694635	0.953009	0.021	0	0
Chaperonin-mediated protein folding	R-HSA-390466	0.954045	0.020	0	0
Nucleotide Excision Repair	R-HSA-5696398	0.954498	0.020	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	0.954969	0.020	0	0
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	0.955905	0.020	0	0
Glycogen synthesis	R-HSA-3322077	0.955905	0.020	0	0
Pregnenolone biosynthesis	R-HSA-196108	0.955905	0.020	0	0
Eicosanoid ligand-binding receptors	R-HSA-391903	0.955905	0.020	0	0
PCP/CE pathway	R-HSA-4086400	0.956342	0.019	0	0
Surfactant metabolism	R-HSA-5683826	0.956797	0.019	0	0
Amine ligand-binding receptors	R-HSA-375280	0.956797	0.019	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	0.957463	0.019	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	0.957463	0.019	0	0
Metabolism of amine-derived hormones	R-HSA-209776	0.957463	0.019	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	0.958974	0.018	0	0
Glutamate and glutamine metabolism	R-HSA-8964539	0.959415	0.018	0	0
ER-Phagosome pathway	R-HSA-1236974	0.960061	0.018	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	0.960617	0.017	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	0.960617	0.017	0	0
Regulation of CDH1 Function	R-HSA-9764561	0.960921	0.017	0	0
FGFR2 ligand binding and activation	R-HSA-190241	0.961085	0.017	0	0
Matriglycan biosynthesis on DAG1	R-HSA-9939291	0.961085	0.017	0	0
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	0.961085	0.017	0	0
Abacavir metabolism	R-HSA-2161541	0.961085	0.017	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	0.961085	0.017	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	0.961085	0.017	0	0
G alpha (s) signalling events	R-HSA-418555	0.961878	0.017	0	0
Antigen processing-Cross presentation	R-HSA-1236975	0.962500	0.017	0	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	0.963438	0.016	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	0.963438	0.016	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	0.963438	0.016	0	0
Signal amplification	R-HSA-392518	0.963438	0.016	0	0
Hyaluronan metabolism	R-HSA-2142845	0.963438	0.016	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	0.963438	0.016	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	0.963438	0.016	0	0
Dual incision in TC-NER	R-HSA-6782135	0.964117	0.016	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	0.964117	0.016	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	0.964117	0.016	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	0.964117	0.016	0	0
Selenoamino acid metabolism	R-HSA-2408522	0.965430	0.015	0	0
Interleukin-17 signaling	R-HSA-448424	0.965541	0.015	0	0
Attachment and Entry	R-HSA-9694614	0.965656	0.015	0	0
Ribavirin ADME	R-HSA-9755088	0.965656	0.015	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	0.967029	0.015	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	0.967068	0.015	0	0
Regulation of Apoptosis	R-HSA-169911	0.967077	0.015	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	0.967077	0.015	1	1
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	0.967323	0.014	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	0.967323	0.014	0	0
ECM proteoglycans	R-HSA-3000178	0.968198	0.014	0	0
rRNA processing	R-HSA-72312	0.968785	0.014	0	0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	0.969691	0.013	0	0
RAF-independent MAPK1/3 activation	R-HSA-112409	0.969691	0.013	0	0
LDL clearance	R-HSA-8964038	0.969691	0.013	0	0
Fructose metabolism	R-HSA-5652084	0.969691	0.013	0	0
Neurotoxicity of clostridium toxins	R-HSA-168799	0.969691	0.013	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	0.969691	0.013	0	0
GABA receptor activation	R-HSA-977443	0.969792	0.013	0	0
Protein folding	R-HSA-391251	0.970005	0.013	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	0.970005	0.013	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	0.970005	0.013	0	0
Intraflagellar transport	R-HSA-5620924	0.970257	0.013	0	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	0.970365	0.013	0	0
SARS-CoV Infections	R-HSA-9679506	0.971005	0.013	0	0
Interferon Signaling	R-HSA-913531	0.971478	0.013	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	0.972303	0.012	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	0.973252	0.012	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	0.973252	0.012	0	0
Termination of O-glycan biosynthesis	R-HSA-977068	0.973252	0.012	0	0
Biosynthesis of maresins	R-HSA-9018682	0.973252	0.012	0	0
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	0.973252	0.012	0	0
Organic anion transport by SLCO transporters	R-HSA-879518	0.973252	0.012	0	0
ABC transporters in lipid homeostasis	R-HSA-1369062	0.973252	0.012	0	0
Degradation of DVL	R-HSA-4641258	0.973336	0.012	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	0.973336	0.012	0	0
Beta-oxidation of very long chain fatty acids	R-HSA-390247	0.973336	0.012	0	0
Metabolism of folate and pterines	R-HSA-196757	0.973336	0.012	0	0
NCAM1 interactions	R-HSA-419037	0.973336	0.012	0	0
Collagen chain trimerization	R-HSA-8948216	0.973336	0.012	0	0
Collagen formation	R-HSA-1474290	0.974077	0.011	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	0.974619	0.011	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	0.975875	0.011	0	0
Circadian clock	R-HSA-9909396	0.976386	0.010	0	0
CYP2E1 reactions	R-HSA-211999	0.976394	0.010	0	0
Thromboxane signalling through TP receptor	R-HSA-428930	0.976394	0.010	0	0
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	0.976394	0.010	0	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	0.976394	0.010	0	0
Synthesis of dolichyl-phosphate	R-HSA-446199	0.976394	0.010	0	0
Interleukin-6 family signaling	R-HSA-6783589	0.976394	0.010	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	0.977041	0.010	0	0
Formation of the cornified envelope	R-HSA-6809371	0.977092	0.010	0	0
The phototransduction cascade	R-HSA-2514856	0.977633	0.010	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	0.977972	0.010	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	0.978438	0.009	0	0
Plasma lipoprotein clearance	R-HSA-8964043	0.978438	0.009	0	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	0.978438	0.009	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	0.978438	0.009	0	0
Alpha-oxidation of phytanate	R-HSA-389599	0.979168	0.009	0	0
Beta-oxidation of pristanoyl-CoA	R-HSA-389887	0.979168	0.009	0	0
Hyaluronan degradation	R-HSA-2160916	0.979168	0.009	0	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	0.979168	0.009	0	0
Platelet homeostasis	R-HSA-418346	0.979226	0.009	0	0
Interleukin-12 family signaling	R-HSA-447115	0.979631	0.009	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	0.979678	0.009	0	0
Cellular response to hypoxia	R-HSA-1234174	0.980521	0.009	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	0.980620	0.008	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	0.980620	0.008	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	0.980620	0.008	0	0
Tryptophan catabolism	R-HSA-71240	0.980620	0.008	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	0.981544	0.008	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	0.981544	0.008	0	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	0.981616	0.008	0	0
Metalloprotease DUBs	R-HSA-5689901	0.981616	0.008	0	0
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	0.981616	0.008	0	0
Abacavir ADME	R-HSA-2161522	0.981616	0.008	0	0
Sphingolipid catabolism	R-HSA-9845614	0.981616	0.008	0	0
Integrin cell surface interactions	R-HSA-216083	0.982104	0.008	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	0.982588	0.008	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	0.982588	0.008	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	0.983245	0.007	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	0.983415	0.007	0	0
Triglyceride biosynthesis	R-HSA-75109	0.983776	0.007	0	0
Synthesis of PE	R-HSA-1483213	0.983776	0.007	0	0
Insulin processing	R-HSA-264876	0.983776	0.007	0	0
Downstream TCR signaling	R-HSA-202424	0.983935	0.007	0	0
Intra-Golgi traffic	R-HSA-6811438	0.984360	0.007	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	0.984796	0.007	0	0
G alpha (z) signalling events	R-HSA-418597	0.984796	0.007	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	0.985109	0.007	0	0
Iron assimilation using enterobactin	R-HSA-9638334	0.985683	0.006	0	0
Pyrimidine salvage	R-HSA-73614	0.985683	0.006	0	0
Activation of GABAB receptors	R-HSA-991365	0.985957	0.006	0	0
GABA B receptor activation	R-HSA-977444	0.985957	0.006	0	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	0.985957	0.006	0	0
IRE1alpha activates chaperones	R-HSA-381070	0.986315	0.006	0	0
Thyroxine biosynthesis	R-HSA-209968	0.987366	0.006	0	0
Glucagon-type ligand receptors	R-HSA-420092	0.987366	0.006	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	0.987366	0.006	0	0
Activation of Matrix Metalloproteinases	R-HSA-1592389	0.987366	0.006	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	0.987395	0.006	0	0
Defensins	R-HSA-1461973	0.987395	0.006	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	0.987576	0.005	0	0
Neddylation	R-HSA-8951664	0.987936	0.005	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	0.988284	0.005	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	0.988361	0.005	0	0
Retinoid metabolism and transport	R-HSA-975634	0.988658	0.005	0	0
Gap junction trafficking	R-HSA-190828	0.988689	0.005	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	0.988851	0.005	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	0.989254	0.005	0	0
Peroxisomal protein import	R-HSA-9033241	0.989730	0.004	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	0.989853	0.004	0	0
Fanconi Anemia Pathway	R-HSA-6783310	0.989853	0.004	0	0
Somitogenesis	R-HSA-9824272	0.989853	0.004	0	0
Budding and maturation of HIV virion	R-HSA-162588	0.990161	0.004	0	0
Cargo concentration in the ER	R-HSA-5694530	0.990161	0.004	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	0.990161	0.004	0	0
Molecules associated with elastic fibres	R-HSA-2129379	0.990161	0.004	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	0.990697	0.004	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	0.990755	0.004	0	0
Disorders of transmembrane transporters	R-HSA-5619115	0.991293	0.004	0	0
DAG1 glycosylations	R-HSA-8931838	0.991318	0.004	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	0.991318	0.004	0	0
HS-GAG degradation	R-HSA-2024096	0.991318	0.004	0	0
Formation of paraxial mesoderm	R-HSA-9793380	0.991577	0.004	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	0.991710	0.004	0	0
Iron uptake and transport	R-HSA-917937	0.992152	0.003	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	0.992338	0.003	0	0
Defective B3GALTL causes PpS	R-HSA-5083635	0.992338	0.003	0	0
G-protein beta:gamma signalling	R-HSA-397795	0.992338	0.003	0	0
Mitochondrial protein import	R-HSA-1268020	0.992376	0.003	0	0
SARS-CoV-2 Infection	R-HSA-9694516	0.992668	0.003	0	0
UCH proteinases	R-HSA-5689603	0.992849	0.003	0	0
Post-translational protein phosphorylation	R-HSA-8957275	0.992903	0.003	0	0
Leishmania infection	R-HSA-9658195	0.992978	0.003	0	0
Parasitic Infection Pathways	R-HSA-9824443	0.992978	0.003	0	0
Acyl chain remodelling of PC	R-HSA-1482788	0.993239	0.003	0	0
Vpu mediated degradation of CD4	R-HSA-180534	0.993239	0.003	0	0
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	0.994034	0.003	0	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	0.994034	0.003	0	0
Calnexin/calreticulin cycle	R-HSA-901042	0.994034	0.003	0	0
Gap junction assembly	R-HSA-190861	0.994034	0.003	0	0
Phosphate bond hydrolysis by NUDT proteins	R-HSA-2393930	0.994034	0.003	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	0.994162	0.003	0	0
FCERI mediated MAPK activation	R-HSA-2871796	0.994481	0.002	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	0.994735	0.002	0	0
Acyl chain remodelling of PE	R-HSA-1482839	0.994735	0.002	0	0
Transferrin endocytosis and recycling	R-HSA-917977	0.994735	0.002	0	0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	R-HSA-193775	0.994735	0.002	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	0.994740	0.002	0	0
Complex IV assembly	R-HSA-9864848	0.994740	0.002	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	0.994740	0.002	0	0
Branched-chain amino acid catabolism	R-HSA-70895	0.994740	0.002	0	0
HS-GAG biosynthesis	R-HSA-2022928	0.995354	0.002	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	0.995530	0.002	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	0.995530	0.002	0	0
PPARA activates gene expression	R-HSA-1989781	0.995657	0.002	0	0
O-glycosylation of TSR domain-containing proteins	R-HSA-5173214	0.995901	0.002	0	0
Degradation of AXIN	R-HSA-4641257	0.995901	0.002	0	0
Lysine catabolism	R-HSA-71064	0.995901	0.002	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	0.996239	0.002	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	0.996357	0.002	0	0
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	0.996383	0.002	0	0
Purine salvage	R-HSA-74217	0.996383	0.002	0	0
Elastic fibre formation	R-HSA-1566948	0.996383	0.002	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	0.996593	0.001	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	0.996621	0.001	0	0
Signaling by NOTCH3	R-HSA-9012852	0.996621	0.001	0	0
RAS processing	R-HSA-9648002	0.996808	0.001	0	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	0.996933	0.001	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	0.996977	0.001	0	0
rRNA processing in the mitochondrion	R-HSA-8868766	0.997184	0.001	0	0
Mitochondrial tRNA aminoacylation	R-HSA-379726	0.997184	0.001	0	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	0.997232	0.001	0	0
Dectin-2 family	R-HSA-5621480	0.997296	0.001	0	0
Synthesis of PA	R-HSA-1483166	0.997296	0.001	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	0.997394	0.001	0	0
Parasite infection	R-HSA-9664407	0.997394	0.001	0	0
Leishmania phagocytosis	R-HSA-9664417	0.997394	0.001	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	0.997515	0.001	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	0.997581	0.001	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	0.997581	0.001	0	0
Signaling by NOTCH4	R-HSA-9013694	0.997747	0.001	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	0.997807	0.001	0	0
Scavenging by Class A Receptors	R-HSA-3000480	0.997807	0.001	0	0
Heme biosynthesis	R-HSA-189451	0.997807	0.001	0	0
Hemostasis	R-HSA-109582	0.997969	0.001	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	0.998065	0.001	0	0
RAB geranylgeranylation	R-HSA-8873719	0.998066	0.001	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	0.998089	0.001	0	0
Nucleotide salvage	R-HSA-8956321	0.998271	0.001	0	0
Collagen degradation	R-HSA-1442490	0.998271	0.001	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	0.998293	0.001	0	0
Class B/2 (Secretin family receptors)	R-HSA-373080	0.998293	0.001	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	0.998456	0.001	0	0
Methylation	R-HSA-156581	0.998494	0.001	0	0
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	0.998494	0.001	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	0.998501	0.001	0	0
ABC transporter disorders	R-HSA-5619084	0.998512	0.001	0	0
SLC-mediated transport of organic anions	R-HSA-9955298	0.998512	0.001	0	0
GPCR downstream signalling	R-HSA-388396	0.998549	0.001	0	0
Complex I biogenesis	R-HSA-6799198	0.998619	0.001	0	0
Immune System	R-HSA-168256	0.998634	0.001	0	0
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	0.998671	0.001	0	0
Degradation of cysteine and homocysteine	R-HSA-1614558	0.998671	0.001	0	0
Platelet degranulation	R-HSA-114608	0.998776	0.001	0	0
PKR-mediated signaling	R-HSA-9833482	0.998793	0.001	0	0
Regulation of pyruvate metabolism	R-HSA-9861718	0.998827	0.001	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	0.998929	0.000	0	0
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	0.998965	0.000	0	0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	0.998965	0.000	0	0
Synthesis of PC	R-HSA-1483191	0.998965	0.000	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	0.999016	0.000	0	0
Phospholipid metabolism	R-HSA-1483257	0.999051	0.000	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	0.999077	0.000	0	0
Plasma lipoprotein remodeling	R-HSA-8963899	0.999087	0.000	0	0
Gluconeogenesis	R-HSA-70263	0.999087	0.000	0	0
Cytoprotection by HMOX1	R-HSA-9707564	0.999119	0.000	0	0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	0.999121	0.000	0	0
Metabolism of steroid hormones	R-HSA-196071	0.999121	0.000	0	0
Nicotinate metabolism	R-HSA-196807	0.999121	0.000	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	0.999194	0.000	0	0
Degradation of the extracellular matrix	R-HSA-1474228	0.999274	0.000	0	0
Azathioprine ADME	R-HSA-9748787	0.999289	0.000	0	0
Cellular response to chemical stress	R-HSA-9711123	0.999320	0.000	0	0
COPII-mediated vesicle transport	R-HSA-204005	0.999375	0.000	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	0.999425	0.000	0	0
Metabolism of cofactors	R-HSA-8978934	0.999442	0.000	0	0
G alpha (i) signalling events	R-HSA-418594	0.999444	0.000	0	0
tRNA processing	R-HSA-72306	0.999472	0.000	0	0
Pyruvate metabolism	R-HSA-70268	0.999481	0.000	0	0
Purine catabolism	R-HSA-74259	0.999502	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	0.999565	0.000	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	0.999573	0.000	0	0
Paracetamol ADME	R-HSA-9753281	0.999620	0.000	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	0.999641	0.000	0	0
Citric acid cycle (TCA cycle)	R-HSA-71403	0.999646	0.000	0	0
Digestion	R-HSA-8935690	0.999665	0.000	0	0
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	0.999686	0.000	0	0
RSV-host interactions	R-HSA-9833110	0.999686	0.000	0	0
Protein localization	R-HSA-9609507	0.999703	0.000	0	0
Interleukin-10 signaling	R-HSA-6783783	0.999749	0.000	0	0
Cholesterol biosynthesis	R-HSA-191273	0.999749	0.000	0	0
Heparan sulfate/heparin (HS-GAG) metabolism	R-HSA-1638091	0.999770	0.000	0	0
Viral Infection Pathways	R-HSA-9824446	0.999770	0.000	0	0
Signaling by GPCR	R-HSA-372790	0.999783	0.000	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	0.999792	0.000	0	0
tRNA Aminoacylation	R-HSA-379724	0.999797	0.000	0	0
Metabolism of polyamines	R-HSA-351202	0.999797	0.000	0	0
G alpha (q) signalling events	R-HSA-416476	0.999808	0.000	0	0
Bile acid and bile salt metabolism	R-HSA-194068	0.999830	0.000	0	0
Visual phototransduction	R-HSA-2187338	0.999842	0.000	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	0.999854	0.000	0	0
Leishmania parasite growth and survival	R-HSA-9664433	0.999854	0.000	0	0
Digestion and absorption	R-HSA-8963743	0.999861	0.000	0	0
Peroxisomal lipid metabolism	R-HSA-390918	0.999874	0.000	0	0
Xenobiotics	R-HSA-211981	0.999877	0.000	0	0
Latent infection - Other responses of Mtb to phagocytosis	R-HSA-1222499	0.999891	0.000	0	0
ABC-family proteins mediated transport	R-HSA-382556	0.999897	0.000	0	0
Interferon alpha/beta signaling	R-HSA-909733	0.999917	0.000	0	0
O-linked glycosylation of mucins	R-HSA-913709	0.999925	0.000	0	0
Peptide hormone metabolism	R-HSA-2980736	0.999933	0.000	0	0
Glycosphingolipid catabolism	R-HSA-9840310	0.999942	0.000	0	0
Metal ion assimilation from the host	R-HSA-9638482	0.999949	0.000	0	0
Metabolism of porphyrins	R-HSA-189445	0.999949	0.000	0	0
Extracellular matrix organization	R-HSA-1474244	0.999959	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	0.999960	0.000	0	0
Diseases of carbohydrate metabolism	R-HSA-5663084	0.999960	0.000	0	0
Aspirin ADME	R-HSA-9749641	0.999960	0.000	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	0.999965	0.000	0	0
Antimicrobial peptides	R-HSA-6803157	0.999972	0.000	0	0
Keratinization	R-HSA-6805567	0.999977	0.000	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	0.999978	0.000	0	0
Mitochondrial translation elongation	R-HSA-5389840	0.999978	0.000	0	0
Translation	R-HSA-72766	0.999980	0.000	0	0
Mitochondrial translation initiation	R-HSA-5368286	0.999983	0.000	0	0
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	0.999985	0.000	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	0.999990	0.000	0	0
Mitochondrial ribosome-associated quality control	R-HSA-9937383	0.999990	0.000	0	0
Sulfur amino acid metabolism	R-HSA-1614635	0.999993	0.000	0	0
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	0.999995	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	0.999995	0.000	0	0
Mitochondrial translation termination	R-HSA-5419276	0.999996	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	0.999996	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	0.999996	0.000	0	0
FCGR activation	R-HSA-2029481	0.999997	0.000	0	0
Post-translational protein modification	R-HSA-597592	0.999998	0.000	1	0
Sensory perception of taste	R-HSA-9717189	0.999998	0.000	0	0
Metabolism of steroids	R-HSA-8957322	0.999998	0.000	0	0
Scavenging of heme from plasma	R-HSA-2168880	0.999998	0.000	0	0
Innate Immune System	R-HSA-168249	0.999998	0.000	0	0
O-linked glycosylation	R-HSA-5173105	0.999999	0.000	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	0.999999	0.000	0	0
Respiratory electron transport	R-HSA-611105	1.000000	0.000	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	1.000000	0.000	0	0
Nucleotide catabolism	R-HSA-8956319	1.000000	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	1.000000	0.000	0	0
Mitochondrial translation	R-HSA-5368287	1.000000	0.000	0	0
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	1.000000	0.000	0	0
Glycosphingolipid metabolism	R-HSA-1660662	1.000000	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	1.000000	0.000	0	0
Regulation of Complement cascade	R-HSA-977606	1.000000	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	1.000000	0.000	0	0
Disease	R-HSA-1643685	1.000000	0.000	0	0
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	1.000000	0.000	0	0
Transport of small molecules	R-HSA-382551	1.000000	0.000	0	0
Infectious disease	R-HSA-5663205	1.000000	0.000	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	1.000000	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	1.000000	0.000	0	0
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000	0.000	0	0
Complement cascade	R-HSA-166658	1.000000	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000	0.000	0	0
Asparagine N-linked glycosylation	R-HSA-446203	1.000000	0.000	0	0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000	0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000	0.000	0	0
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000	0.000	0	0
Drug ADME	R-HSA-9748784	1.000000	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000	0.000	0	0
Metabolism of proteins	R-HSA-392499	1.000000	0.000	1	0
Infection with Enterobacteria	R-HSA-9640148	1.000000	0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000	0.000	0	0
Phase II - Conjugation of compounds	R-HSA-156580	1.000000	0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000	0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000	0.000	0	0
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000	-0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000	-0.000	0	0
Olfactory Signaling Pathway	R-HSA-381753	1.000000	-0.000	0	0
Biological oxidations	R-HSA-211859	1.000000	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000	-0.000	0	0

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p	ref_path	ref_path_lowest
Cellular responses to stress	R-HSA-2262752	1.110223e-16	15.955	0	0
Cellular responses to stimuli	R-HSA-8953897	1.110223e-16	15.955	0	0
Cellular response to heat stress	R-HSA-3371556	8.881784e-16	15.051	0	0
Attenuation phase	R-HSA-3371568	8.393286e-14	13.076	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	4.781731e-13	12.320	0	0
HSF1-dependent transactivation	R-HSA-3371571	5.826450e-13	12.235	0	0
HSF1 activation	R-HSA-3371511	1.806322e-11	10.743	0	0
M Phase	R-HSA-68886	2.361566e-11	10.627	0	0
Nervous system development	R-HSA-9675108	2.212186e-11	10.655	0	0
Axon guidance	R-HSA-422475	4.533163e-11	10.344	0	0
Signal Transduction	R-HSA-162582	5.683976e-11	10.245	0	0
Cell Cycle	R-HSA-1640170	1.374449e-10	9.862	1	0
Cell Cycle, Mitotic	R-HSA-69278	6.781069e-10	9.169	1	0
Cell Cycle Checkpoints	R-HSA-69620	7.140824e-09	8.146	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	1.476775e-08	7.831	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.431965e-08	7.844	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.634797e-08	7.787	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	2.174731e-08	7.663	0	0
Mitotic Anaphase	R-HSA-68882	3.306735e-08	7.481	0	0
Cell junction organization	R-HSA-446728	3.539525e-08	7.451	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	3.775124e-08	7.423	0	0
DNA Double Strand Break Response	R-HSA-5693606	4.798526e-08	7.319	0	0
Cell-Cell communication	R-HSA-1500931	4.790400e-08	7.320	0	0
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	7.285470e-08	7.138	0	0
Signaling by ROBO receptors	R-HSA-376176	7.356706e-08	7.133	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	9.940063e-08	7.003	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	1.102405e-07	6.958	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	1.102405e-07	6.958	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	2.300895e-07	6.638	0	0
Aggrephagy	R-HSA-9646399	3.156783e-07	6.501	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	4.511714e-07	6.346	0	0
Nucleosome assembly	R-HSA-774815	4.511714e-07	6.346	0	0
HDACs deacetylate histones	R-HSA-3214815	4.432932e-07	6.353	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	4.083772e-07	6.389	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	5.135103e-07	6.289	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	6.115057e-07	6.214	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	7.042508e-07	6.152	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	9.225322e-07	6.035	0	0
G2/M Checkpoints	R-HSA-69481	9.087082e-07	6.042	0	0
Cap-dependent Translation Initiation	R-HSA-72737	9.890834e-07	6.005	0	0
Eukaryotic Translation Initiation	R-HSA-72613	9.890834e-07	6.005	0	0
Meiotic synapsis	R-HSA-1221632	1.000595e-06	6.000	0	0
Separation of Sister Chromatids	R-HSA-2467813	1.056122e-06	5.976	0	0
Adherens junctions interactions	R-HSA-418990	1.241718e-06	5.906	0	0
Packaging Of Telomere Ends	R-HSA-171306	1.316806e-06	5.880	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	1.479575e-06	5.830	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.521636e-06	5.818	0	0
Eukaryotic Translation Elongation	R-HSA-156842	1.496572e-06	5.825	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	1.461269e-06	5.835	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	1.571187e-06	5.804	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	1.571187e-06	5.804	0	0
PRC2 methylates histones and DNA	R-HSA-212300	1.734983e-06	5.761	0	0
Selective autophagy	R-HSA-9663891	1.773241e-06	5.751	0	0
Mitotic Prophase	R-HSA-68875	1.869109e-06	5.728	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	2.094853e-06	5.679	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	2.181327e-06	5.661	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	2.648552e-06	5.577	0	0
DNA methylation	R-HSA-5334118	2.666912e-06	5.574	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	3.340993e-06	5.476	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	3.603539e-06	5.443	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	3.677232e-06	5.434	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	3.766634e-06	5.424	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	4.020907e-06	5.396	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	4.061337e-06	5.391	0	0
Cell-cell junction organization	R-HSA-421270	4.285178e-06	5.368	0	0
Metabolism of RNA	R-HSA-8953854	4.398593e-06	5.357	0	0
Post NMDA receptor activation events	R-HSA-438064	4.401921e-06	5.356	0	0
Translation initiation complex formation	R-HSA-72649	4.639131e-06	5.334	0	0
Assembly of the pre-replicative complex	R-HSA-68867	5.211310e-06	5.283	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	6.013211e-06	5.221	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	6.297875e-06	5.201	0	0
RNA Polymerase I Promoter Opening	R-HSA-73728	6.350073e-06	5.197	0	0
Regulation of PTEN localization	R-HSA-8948747	7.804310e-06	5.108	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	7.502292e-06	5.125	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	7.502292e-06	5.125	0	0
Meiosis	R-HSA-1500620	7.540983e-06	5.123	0	0
Mitotic Prometaphase	R-HSA-68877	7.733596e-06	5.112	0	0
Meiotic recombination	R-HSA-912446	8.121385e-06	5.090	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	8.832657e-06	5.054	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	8.627807e-06	5.064	0	0
Apoptotic execution phase	R-HSA-75153	8.835318e-06	5.054	0	0
G2/M DNA damage checkpoint	R-HSA-69473	8.865045e-06	5.052	0	0
Regulation of CDH1 Function	R-HSA-9764561	9.127034e-06	5.040	0	0
Cleavage of the damaged purine	R-HSA-110331	9.637170e-06	5.016	0	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	9.495440e-06	5.022	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	1.022270e-05	4.990	0	0
Estrogen-dependent gene expression	R-HSA-9018519	1.113080e-05	4.953	0	0
Recycling pathway of L1	R-HSA-437239	1.124622e-05	4.949	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	1.224622e-05	4.912	0	0
Depurination	R-HSA-73927	1.263764e-05	4.898	0	0
Peptide chain elongation	R-HSA-156902	1.507142e-05	4.822	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.537667e-05	4.813	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	1.537667e-05	4.813	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.585559e-05	4.800	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.721100e-05	4.764	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	1.844817e-05	4.734	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	2.082421e-05	4.681	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	2.123241e-05	4.673	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	2.578617e-05	4.589	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	2.578617e-05	4.589	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	2.783044e-05	4.555	0	0
Autophagy	R-HSA-9612973	2.745741e-05	4.561	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	2.891533e-05	4.539	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	3.049459e-05	4.516	0	0
Amyloid fiber formation	R-HSA-977225	3.111541e-05	4.507	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	3.138892e-05	4.503	0	0
ISG15 antiviral mechanism	R-HSA-1169408	3.169229e-05	4.499	0	0
Intracellular signaling by second messengers	R-HSA-9006925	3.198526e-05	4.495	0	0
DNA Replication Pre-Initiation	R-HSA-69002	3.207992e-05	4.494	0	0
Influenza Infection	R-HSA-168255	3.731162e-05	4.428	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	3.731985e-05	4.428	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	3.771281e-05	4.424	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	3.809040e-05	4.419	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	3.878674e-05	4.411	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	4.253760e-05	4.371	0	0
Ub-specific processing proteases	R-HSA-5689880	4.223543e-05	4.374	0	0
HATs acetylate histones	R-HSA-3214847	4.291821e-05	4.367	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	4.349386e-05	4.362	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	4.250758e-05	4.372	1	0
Cleavage of the damaged pyrimidine	R-HSA-110329	4.383622e-05	4.358	0	0
Depyrimidination	R-HSA-73928	4.383622e-05	4.358	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	4.551832e-05	4.342	0	0
HCMV Early Events	R-HSA-9609690	4.834978e-05	4.316	0	0
Macroautophagy	R-HSA-1632852	4.863932e-05	4.313	0	0
Folding of actin by CCT/TriC	R-HSA-390450	4.945073e-05	4.306	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	5.321376e-05	4.274	0	0
Deubiquitination	R-HSA-5688426	5.018758e-05	4.299	0	0
RNA Polymerase I Transcription	R-HSA-73864	5.291290e-05	4.276	0	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	4.966961e-05	4.304	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	5.405470e-05	4.267	0	0
Kinesins	R-HSA-983189	5.405470e-05	4.267	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	5.466688e-05	4.262	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	6.569759e-05	4.182	0	0
Developmental Biology	R-HSA-1266738	7.167314e-05	4.145	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	7.336867e-05	4.134	0	0
ESR-mediated signaling	R-HSA-8939211	7.581694e-05	4.120	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	7.671054e-05	4.115	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	7.848402e-05	4.105	0	0
Protein ubiquitination	R-HSA-8852135	8.985288e-05	4.046	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	8.605549e-05	4.065	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.320247e-05	4.031	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	9.357143e-05	4.029	0	0
Chaperonin-mediated protein folding	R-HSA-390466	9.479524e-05	4.023	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	9.682633e-05	4.014	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	9.682633e-05	4.014	0	0
Membrane Trafficking	R-HSA-199991	1.058673e-04	3.975	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	1.089641e-04	3.963	0	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	1.182932e-04	3.927	0	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	1.313537e-04	3.882	0	0
Signaling by WNT	R-HSA-195721	1.334560e-04	3.875	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	1.357950e-04	3.867	0	0
Homology Directed Repair	R-HSA-5693538	1.360199e-04	3.866	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	1.498500e-04	3.824	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	1.476202e-04	3.831	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.364443e-04	3.865	1	1
Base-Excision Repair, AP Site Formation	R-HSA-73929	1.619530e-04	3.791	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	1.694718e-04	3.771	0	0
Ribosome-associated quality control	R-HSA-9948299	1.714185e-04	3.766	0	0
Cellular Senescence	R-HSA-2559583	1.787757e-04	3.748	0	0
Amplification of signal from the kinetochores	R-HSA-141424	1.831780e-04	3.737	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	1.831780e-04	3.737	0	0
Defective pyroptosis	R-HSA-9710421	1.847378e-04	3.733	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	1.947979e-04	3.710	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	1.965185e-04	3.707	0	0
Regulation of TP53 Activity	R-HSA-5633007	1.981932e-04	3.703	1	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	2.047605e-04	3.689	0	0
Chromatin modifying enzymes	R-HSA-3247509	2.150844e-04	3.667	0	0
Protein folding	R-HSA-391251	2.234829e-04	3.651	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	2.180455e-04	3.661	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	2.281142e-04	3.642	0	0
Apoptosis	R-HSA-109581	2.418240e-04	3.617	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	2.496632e-04	3.603	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	2.636339e-04	3.579	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	2.797610e-04	3.553	0	0
Diseases of programmed cell death	R-HSA-9645723	2.797610e-04	3.553	0	0
G2/M Transition	R-HSA-69275	3.115053e-04	3.507	1	0
mRNA Splicing - Major Pathway	R-HSA-72163	3.241815e-04	3.489	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	3.358711e-04	3.474	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	3.480914e-04	3.458	0	0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	3.581443e-04	3.446	0	0
Mitotic G2-G2/M phases	R-HSA-453274	3.722188e-04	3.429	1	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	3.723968e-04	3.429	0	0
RET signaling	R-HSA-8853659	3.741388e-04	3.427	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	3.768885e-04	3.424	0	0
Eukaryotic Translation Termination	R-HSA-72764	3.787065e-04	3.422	0	0
Chromatin organization	R-HSA-4839726	3.813672e-04	3.419	0	0
Regulation of endogenous retroelements	R-HSA-9842860	3.864124e-04	3.413	0	0
mRNA Splicing	R-HSA-72172	4.327013e-04	3.364	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	4.298647e-04	3.367	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	4.085844e-04	3.389	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	4.486011e-04	3.348	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	4.735192e-04	3.325	0	0
Transport of connexons to the plasma membrane	R-HSA-190872	4.910617e-04	3.309	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	4.923610e-04	3.308	0	0
PKR-mediated signaling	R-HSA-9833482	5.035303e-04	3.298	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	5.396678e-04	3.268	0	0
L1CAM interactions	R-HSA-373760	5.481322e-04	3.261	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	5.899282e-04	3.229	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	6.213303e-04	3.207	0	0
p75NTR signals via NF-kB	R-HSA-193639	6.229866e-04	3.206	0	0
Cell-extracellular matrix interactions	R-HSA-446353	6.229866e-04	3.206	0	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	6.446595e-04	3.191	0	0
Signaling by EGFR	R-HSA-177929	6.639709e-04	3.178	0	0
FLT3 signaling by CBL mutants	R-HSA-9706377	6.656983e-04	3.177	0	0
Hedgehog 'off' state	R-HSA-5610787	6.998526e-04	3.155	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	6.998526e-04	3.155	0	0
UCH proteinases	R-HSA-5689603	7.247309e-04	3.140	0	0
Interleukin-12 signaling	R-HSA-9020591	7.247309e-04	3.140	0	0
Signaling by VEGF	R-HSA-194138	7.401317e-04	3.131	0	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	7.457650e-04	3.127	0	0
Post-chaperonin tubulin folding pathway	R-HSA-389977	8.786917e-04	3.056	0	0
DAG and IP3 signaling	R-HSA-1489509	8.386098e-04	3.076	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	7.893177e-04	3.103	0	0
Base Excision Repair	R-HSA-73884	8.766320e-04	3.057	0	0
Selenocysteine synthesis	R-HSA-2408557	7.868515e-04	3.104	0	0
Gene Silencing by RNA	R-HSA-211000	7.825985e-04	3.106	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	9.497064e-04	3.022	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	9.873019e-04	3.006	0	0
Viral mRNA Translation	R-HSA-192823	9.893032e-04	3.005	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	9.987558e-04	3.001	0	0
p75NTR recruits signalling complexes	R-HSA-209543	1.079284e-03	2.967	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.149733e-03	2.939	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.149733e-03	2.939	0	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	1.174538e-03	2.930	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	1.174538e-03	2.930	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.195382e-03	2.922	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	1.199685e-03	2.921	0	0
Regulation of TP53 Degradation	R-HSA-6804757	1.214505e-03	2.916	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	1.243267e-03	2.905	0	0
Reproduction	R-HSA-1474165	1.342841e-03	2.872	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.468552e-03	2.833	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	1.540149e-03	2.812	0	0
Glycolysis	R-HSA-70171	1.563070e-03	2.806	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	1.582813e-03	2.801	0	0
Programmed Cell Death	R-HSA-5357801	1.598479e-03	2.796	0	0
Gap junction trafficking and regulation	R-HSA-157858	1.640947e-03	2.785	0	0
SARS-CoV-1 Infection	R-HSA-9678108	1.647102e-03	2.783	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	1.671353e-03	2.777	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	1.756167e-03	2.755	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	1.854373e-03	2.732	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	2.059691e-03	2.686	0	0
Pexophagy	R-HSA-9664873	1.854373e-03	2.732	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	2.031434e-03	2.692	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	2.089527e-03	2.680	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	1.893707e-03	2.723	0	0
rRNA processing	R-HSA-72312	1.981125e-03	2.703	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	1.835633e-03	2.736	0	0
Gap junction trafficking	R-HSA-190828	2.031434e-03	2.692	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	2.108652e-03	2.676	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	2.108652e-03	2.676	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	2.130548e-03	2.672	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	2.130548e-03	2.672	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	2.130548e-03	2.672	0	0
HCMV Infection	R-HSA-9609646	2.229650e-03	2.652	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	2.234091e-03	2.651	0	0
Viral Infection Pathways	R-HSA-9824446	2.246146e-03	2.649	0	0
MHC class II antigen presentation	R-HSA-2132295	2.347153e-03	2.629	0	0
Cellular response to chemical stress	R-HSA-9711123	2.469507e-03	2.607	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	2.505304e-03	2.601	0	0
IRE1alpha activates chaperones	R-HSA-381070	2.508160e-03	2.601	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	2.567238e-03	2.591	0	0
mRNA 3'-end processing	R-HSA-72187	2.594781e-03	2.586	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	2.612268e-03	2.583	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	2.669550e-03	2.574	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	2.792793e-03	2.554	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	2.792793e-03	2.554	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	2.792793e-03	2.554	0	0
Signaling by RAS mutants	R-HSA-6802949	2.792793e-03	2.554	0	0
PIP3 activates AKT signaling	R-HSA-1257604	2.808592e-03	2.552	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	2.811445e-03	2.551	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	2.846772e-03	2.546	0	0
Signaling by ERBB2	R-HSA-1227986	3.135223e-03	2.504	0	0
DNA Replication	R-HSA-69306	3.157241e-03	2.501	0	0
Interleukin-12 family signaling	R-HSA-447115	3.181045e-03	2.497	0	0
Death Receptor Signaling	R-HSA-73887	3.419039e-03	2.466	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	3.454301e-03	2.462	0	0
MAP2K and MAPK activation	R-HSA-5674135	3.480872e-03	2.458	0	0
Signaling by RAF1 mutants	R-HSA-9656223	3.480872e-03	2.458	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	3.480872e-03	2.458	0	0
Interferon Signaling	R-HSA-913531	3.538661e-03	2.451	0	0
CaM pathway	R-HSA-111997	3.657050e-03	2.437	0	0
Calmodulin induced events	R-HSA-111933	3.657050e-03	2.437	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	3.657050e-03	2.437	0	0
NF-kB is activated and signals survival	R-HSA-209560	3.727560e-03	2.429	0	0
EGFR downregulation	R-HSA-182971	3.742480e-03	2.427	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	4.507106e-03	2.346	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	4.243413e-03	2.372	0	0
Ca-dependent events	R-HSA-111996	4.072395e-03	2.390	0	0
Chromosome Maintenance	R-HSA-73886	3.890297e-03	2.410	0	0
Metalloprotease DUBs	R-HSA-5689901	4.507106e-03	2.346	0	0
Degradation of CDH1	R-HSA-9766229	4.357726e-03	2.361	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	4.071494e-03	2.390	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	4.618720e-03	2.335	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	4.618720e-03	2.335	0	0
Cellular response to starvation	R-HSA-9711097	4.657942e-03	2.332	0	0
Myoclonic epilepsy of Lafora	R-HSA-3785653	4.662399e-03	2.331	0	0
Downregulation of ERBB4 signaling	R-HSA-1253288	4.662399e-03	2.331	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	4.662399e-03	2.331	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	4.662399e-03	2.331	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	4.812882e-03	2.318	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	4.862487e-03	2.313	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	4.934105e-03	2.307	0	0
Oncogenic MAPK signaling	R-HSA-6802957	5.013236e-03	2.300	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	5.061757e-03	2.296	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	5.068501e-03	2.295	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	5.068501e-03	2.295	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	5.336521e-03	2.273	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	5.353581e-03	2.271	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	5.353581e-03	2.271	0	0
DNA Repair	R-HSA-73894	5.936271e-03	2.226	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	5.953841e-03	2.225	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	6.574180e-03	2.182	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	6.574180e-03	2.182	0	0
AURKA Activation by TPX2	R-HSA-8854518	6.627835e-03	2.179	1	1
Metabolism of non-coding RNA	R-HSA-194441	6.647411e-03	2.177	0	0
snRNP Assembly	R-HSA-191859	6.647411e-03	2.177	0	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	6.664169e-03	2.176	0	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	6.664169e-03	2.176	0	0
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	6.733055e-03	2.172	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	6.733055e-03	2.172	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	6.930680e-03	2.159	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	7.174551e-03	2.144	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	7.174551e-03	2.144	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	7.174551e-03	2.144	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	7.174551e-03	2.144	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	7.174551e-03	2.144	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	7.174551e-03	2.144	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	7.174551e-03	2.144	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	7.174551e-03	2.144	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	7.174551e-03	2.144	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	7.174551e-03	2.144	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	7.174551e-03	2.144	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	8.011072e-03	2.096	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	8.448695e-03	2.073	0	0
Nuclear import of Rev protein	R-HSA-180746	7.462172e-03	2.127	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	8.761742e-03	2.057	0	0
Developmental Cell Lineages	R-HSA-9734767	7.977284e-03	2.098	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	8.011072e-03	2.096	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	8.110310e-03	2.091	0	0
Cilium Assembly	R-HSA-5617833	8.561137e-03	2.067	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	7.678468e-03	2.115	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	8.761742e-03	2.057	0	0
Maturation of protein E	R-HSA-9694493	8.011072e-03	2.096	0	0
Maturation of protein E	R-HSA-9683683	8.011072e-03	2.096	0	0
Signaling by NOTCH	R-HSA-157118	9.089909e-03	2.041	0	0
Josephin domain DUBs	R-HSA-5689877	9.201211e-03	2.036	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	9.256605e-03	2.034	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	9.256605e-03	2.034	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	9.256605e-03	2.034	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	9.326022e-03	2.030	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	9.543053e-03	2.020	0	0
Regulation of signaling by CBL	R-HSA-912631	9.608529e-03	2.017	0	0
Translesion Synthesis by POLH	R-HSA-110320	9.608529e-03	2.017	0	0
Rap1 signalling	R-HSA-392517	9.608529e-03	2.017	0	0
STING mediated induction of host immune responses	R-HSA-1834941	9.608529e-03	2.017	0	0
Glucose metabolism	R-HSA-70326	1.021449e-02	1.991	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	1.028458e-02	1.988	0	0
Signaling by Hedgehog	R-HSA-5358351	1.039489e-02	1.983	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	1.055598e-02	1.977	0	0
MTOR signalling	R-HSA-165159	1.062486e-02	1.974	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	1.098427e-02	1.959	0	0
G alpha (12/13) signalling events	R-HSA-416482	1.103994e-02	1.957	0	0
PTEN Regulation	R-HSA-6807070	1.117449e-02	1.952	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	1.117449e-02	1.952	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	1.119419e-02	1.951	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	1.119419e-02	1.951	0	0
Protein methylation	R-HSA-8876725	1.119419e-02	1.951	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	1.119419e-02	1.951	0	0
Spry regulation of FGF signaling	R-HSA-1295596	1.119419e-02	1.951	0	0
Negative regulation of MET activity	R-HSA-6807004	1.179399e-02	1.928	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.190811e-02	1.924	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	1.203237e-02	1.920	0	0
Epigenetic regulation of gene expression	R-HSA-212165	1.219877e-02	1.914	0	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	1.233539e-02	1.909	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	1.255863e-02	1.901	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	1.281467e-02	1.892	0	0
HIV Life Cycle	R-HSA-162587	1.351258e-02	1.869	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	1.354394e-02	1.868	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.371858e-02	1.863	0	0
Signaling by ALK in cancer	R-HSA-9700206	1.371858e-02	1.863	0	0
Myogenesis	R-HSA-525793	1.378055e-02	1.861	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.406248e-02	1.852	0	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	1.431742e-02	1.844	0	0
Orc1 removal from chromatin	R-HSA-68949	1.551389e-02	1.809	0	0
Stabilization of p53	R-HSA-69541	1.552250e-02	1.809	0	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	1.612320e-02	1.793	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	1.624418e-02	1.789	0	0
Centrosome maturation	R-HSA-380287	1.707391e-02	1.768	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	1.720431e-02	1.764	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	1.720431e-02	1.764	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	1.738356e-02	1.760	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	1.742048e-02	1.759	0	0
Glycogen metabolism	R-HSA-8982491	1.770814e-02	1.752	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.816904e-02	1.741	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	1.866361e-02	1.729	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	1.866361e-02	1.729	0	0
PLC beta mediated events	R-HSA-112043	1.873738e-02	1.727	0	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	1.988199e-02	1.702	0	0
Gap junction assembly	R-HSA-190861	1.988199e-02	1.702	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	2.103388e-02	1.677	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	2.103388e-02	1.677	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	2.290319e-02	1.640	0	0
Type I hemidesmosome assembly	R-HSA-446107	2.290319e-02	1.640	0	0
Formation of annular gap junctions	R-HSA-196025	2.290319e-02	1.640	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	2.568710e-02	1.590	0	0
PKA activation	R-HSA-163615	2.568710e-02	1.590	0	0
Late endosomal microautophagy	R-HSA-9615710	2.209798e-02	1.656	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	2.552304e-02	1.593	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	2.274550e-02	1.643	0	0
FOXO-mediated transcription	R-HSA-9614085	2.344068e-02	1.630	0	0
Telomere Maintenance	R-HSA-157579	2.003352e-02	1.698	0	0
VLDLR internalisation and degradation	R-HSA-8866427	2.061466e-02	1.686	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	2.011249e-02	1.697	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	2.175790e-02	1.662	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	2.016865e-02	1.695	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	2.016865e-02	1.695	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	2.274689e-02	1.643	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	2.494396e-02	1.603	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	2.494396e-02	1.603	0	0
Muscle contraction	R-HSA-397014	2.005161e-02	1.698	0	0
Platelet degranulation	R-HSA-114608	2.293137e-02	1.640	0	0
Signaling by PTK6	R-HSA-8848021	2.292524e-02	1.640	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	2.292524e-02	1.640	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	2.658508e-02	1.575	1	0
FLT3 Signaling	R-HSA-9607240	2.011249e-02	1.697	0	0
Signaling by NOTCH3	R-HSA-9012852	2.162396e-02	1.665	0	0
Selenoamino acid metabolism	R-HSA-2408522	2.097055e-02	1.678	0	0
Modulation by Mtb of host immune system	R-HSA-9637628	2.290319e-02	1.640	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	2.568710e-02	1.590	0	0
NRAGE signals death through JNK	R-HSA-193648	2.401057e-02	1.620	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	2.675348e-02	1.573	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	2.828035e-02	1.549	0	0
Neurodegenerative Diseases	R-HSA-8863678	2.828035e-02	1.549	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	2.828035e-02	1.549	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	2.874930e-02	1.541	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	2.930176e-02	1.533	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	2.930176e-02	1.533	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	2.930176e-02	1.533	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	2.930176e-02	1.533	0	0
Gap junction degradation	R-HSA-190873	3.012762e-02	1.521	0	0
ALK mutants bind TKIs	R-HSA-9700645	3.012762e-02	1.521	0	0
Calcineurin activates NFAT	R-HSA-2025928	3.012762e-02	1.521	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	3.012762e-02	1.521	0	0
Unwinding of DNA	R-HSA-176974	3.012762e-02	1.521	0	0
Host Interactions of HIV factors	R-HSA-162909	3.034092e-02	1.518	0	0
IRS activation	R-HSA-74713	3.114801e-02	1.507	0	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	3.114801e-02	1.507	0	0
Signaling by NOTCH4	R-HSA-9013694	3.117732e-02	1.506	0	0
Vesicle-mediated transport	R-HSA-5653656	3.144836e-02	1.502	0	0
G-protein mediated events	R-HSA-112040	3.332507e-02	1.477	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	3.413901e-02	1.467	0	0
COPI-mediated anterograde transport	R-HSA-6807878	3.416348e-02	1.466	0	0
Manipulation of host energy metabolism	R-HSA-9636667	3.457930e-02	1.461	0	0
MyD88 deficiency (TLR5)	R-HSA-5602680	3.457930e-02	1.461	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	3.517515e-02	1.454	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	3.550912e-02	1.450	0	0
Neutrophil degranulation	R-HSA-6798695	3.561534e-02	1.448	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	3.672260e-02	1.435	0	0
HCMV Late Events	R-HSA-9610379	3.710311e-02	1.431	0	0
Smooth Muscle Contraction	R-HSA-445355	3.767529e-02	1.424	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	3.797739e-02	1.420	0	0
Activation of ATR in response to replication stress	R-HSA-176187	3.797739e-02	1.420	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	3.824021e-02	1.417	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	3.855281e-02	1.414	0	0
Regulation of CDH11 function	R-HSA-9762292	3.855281e-02	1.414	0	0
Co-inhibition by PD-1	R-HSA-389948	3.869599e-02	1.412	0	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	3.869891e-02	1.412	0	0
Translesion synthesis by REV1	R-HSA-110312	3.869891e-02	1.412	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	3.963660e-02	1.402	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	3.973669e-02	1.401	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	4.155376e-02	1.381	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	4.162029e-02	1.381	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	4.238729e-02	1.373	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	4.238729e-02	1.373	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	4.238729e-02	1.373	0	0
Gene expression (Transcription)	R-HSA-74160	4.247517e-02	1.372	1	0
tRNA processing in the nucleus	R-HSA-6784531	4.252655e-02	1.371	0	0
Striated Muscle Contraction	R-HSA-390522	4.289938e-02	1.368	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	4.289938e-02	1.368	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	4.337535e-02	1.363	0	0
Noncanonical activation of NOTCH3	R-HSA-9017802	4.337535e-02	1.363	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	4.337535e-02	1.363	0	0
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	4.337535e-02	1.363	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	4.339497e-02	1.363	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	4.339497e-02	1.363	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	4.535620e-02	1.343	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	4.629037e-02	1.335	0	0
Translesion synthesis by POLI	R-HSA-5656121	4.635262e-02	1.334	0	0
Regulation of NF-kappa B signaling	R-HSA-9758274	4.635262e-02	1.334	0	0
Negative regulation of FLT3	R-HSA-9706369	4.635262e-02	1.334	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	4.644507e-02	1.333	1	1
MAPK family signaling cascades	R-HSA-5683057	4.719478e-02	1.326	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	4.776765e-02	1.321	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	4.798852e-02	1.319	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	4.819117e-02	1.317	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	4.822494e-02	1.317	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	4.822494e-02	1.317	0	0
Mitophagy	R-HSA-5205647	4.822494e-02	1.317	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	4.917794e-02	1.308	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	4.940239e-02	1.306	0	0
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	7.381697e-02	1.132	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	7.381697e-02	1.132	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	7.381697e-02	1.132	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	7.381697e-02	1.132	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	5.903712e-02	1.229	0	0
Translesion synthesis by POLK	R-HSA-5655862	5.484302e-02	1.261	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	6.417230e-02	1.193	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	6.417230e-02	1.193	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	7.335664e-02	1.135	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	7.045959e-02	1.152	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	6.964160e-02	1.157	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	6.705374e-02	1.174	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	7.433491e-02	1.129	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	6.669955e-02	1.176	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	6.388330e-02	1.195	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	5.712471e-02	1.243	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	5.712471e-02	1.243	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	7.106878e-02	1.148	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	5.712471e-02	1.243	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	7.335664e-02	1.135	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	7.433491e-02	1.129	0	0
Ovarian tumor domain proteases	R-HSA-5689896	6.669955e-02	1.176	0	0
Switching of origins to a post-replicative state	R-HSA-69052	5.470060e-02	1.262	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	6.629697e-02	1.179	0	0
Reduction of cytosolic Ca++ levels	R-HSA-418359	5.903712e-02	1.229	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	6.417230e-02	1.193	0	0
Syndecan interactions	R-HSA-3000170	6.465953e-02	1.189	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	5.484302e-02	1.261	1	1
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	5.011856e-02	1.300	0	0
Oncogene Induced Senescence	R-HSA-2559585	5.396260e-02	1.268	0	0
mTORC1-mediated signalling	R-HSA-166208	5.660027e-02	1.247	0	0
Platelet calcium homeostasis	R-HSA-418360	5.591180e-02	1.252	0	0
HIV Infection	R-HSA-162906	6.139782e-02	1.212	0	0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	5.484302e-02	1.261	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	6.575559e-02	1.182	0	0
TBC/RABGAPs	R-HSA-8854214	6.260141e-02	1.203	0	0
RNA Polymerase II Transcription	R-HSA-73857	5.979057e-02	1.223	1	0
PKA activation in glucagon signalling	R-HSA-164378	7.433491e-02	1.129	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	6.669955e-02	1.176	0	0
FLT3 signaling in disease	R-HSA-9682385	6.011914e-02	1.221	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	7.381697e-02	1.132	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	7.381697e-02	1.132	0	0
Glycogen storage diseases	R-HSA-3229121	6.417230e-02	1.193	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	6.623790e-02	1.179	0	0
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	7.106878e-02	1.148	0	0
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	7.106878e-02	1.148	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	5.680809e-02	1.246	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	6.260141e-02	1.203	0	0
IRAK1 recruits IKK complex	R-HSA-937039	7.106878e-02	1.148	0	0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	7.106878e-02	1.148	0	0
SARS-CoV-2 Infection	R-HSA-9694516	5.066149e-02	1.295	0	0
SARS-CoV Infections	R-HSA-9679506	7.040022e-02	1.152	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	7.527805e-02	1.123	0	0
PCP/CE pathway	R-HSA-4086400	7.844793e-02	1.105	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	7.850274e-02	1.105	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	8.114285e-02	1.091	0	0
Interleukin-1 signaling	R-HSA-9020702	8.166813e-02	1.088	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	8.216593e-02	1.085	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	8.258111e-02	1.083	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	8.268824e-02	1.083	0	0
Sema4D in semaphorin signaling	R-HSA-400685	8.268824e-02	1.083	0	0
Formation of axial mesoderm	R-HSA-9796292	8.424990e-02	1.074	0	0
Membrane binding and targetting of GAG proteins	R-HSA-174490	8.424990e-02	1.074	0	0
IRAK4 deficiency (TLR5)	R-HSA-5603037	8.483332e-02	1.071	0	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	8.531810e-02	1.069	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	8.531810e-02	1.069	0	0
Nuclear RNA decay	R-HSA-9930044	8.705743e-02	1.060	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	8.705743e-02	1.060	0	0
Regulation of necroptotic cell death	R-HSA-5675482	8.705743e-02	1.060	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	8.757879e-02	1.058	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	8.826984e-02	1.054	0	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	8.826984e-02	1.054	0	0
S Phase	R-HSA-69242	8.852003e-02	1.053	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	8.900660e-02	1.051	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	8.900660e-02	1.051	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	8.900660e-02	1.051	0	0
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	8.942101e-02	1.049	0	0
Signaling by FGFR2	R-HSA-5654738	8.954724e-02	1.048	0	0
Rab regulation of trafficking	R-HSA-9007101	8.967245e-02	1.047	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	9.176674e-02	1.037	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	9.176674e-02	1.037	0	0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	9.176674e-02	1.037	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	9.195046e-02	1.036	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	9.264690e-02	1.033	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	9.264690e-02	1.033	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	9.587183e-02	1.018	0	0
Ion homeostasis	R-HSA-5578775	9.587183e-02	1.018	0	0
TNF signaling	R-HSA-75893	9.587183e-02	1.018	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.587183e-02	1.018	0	0
Vpu mediated degradation of CD4	R-HSA-180534	9.611936e-02	1.017	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	9.611936e-02	1.017	0	0
Gluconeogenesis	R-HSA-70263	9.704228e-02	1.013	0	0
Formation of definitive endoderm	R-HSA-9823730	9.710237e-02	1.013	0	0
Nephrin family interactions	R-HSA-373753	9.710237e-02	1.013	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	9.710237e-02	1.013	0	0
Glycogen synthesis	R-HSA-3322077	9.710237e-02	1.013	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	9.729594e-02	1.012	0	0
PKMTs methylate histone lysines	R-HSA-3214841	9.729594e-02	1.012	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	9.729594e-02	1.012	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	9.729594e-02	1.012	0	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	9.853181e-02	1.006	0	0
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	9.853181e-02	1.006	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	1.011875e-01	0.995	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	1.032213e-01	0.986	0	0
Signaling by ERBB4	R-HSA-1236394	1.048622e-01	0.979	0	0
DNA Damage Bypass	R-HSA-73893	1.050274e-01	0.979	0	0
RAF activation	R-HSA-5673000	1.056817e-01	0.976	0	0
Dual Incision in GG-NER	R-HSA-5696400	1.056817e-01	0.976	0	0
Signaling by NOTCH2	R-HSA-1980145	1.056817e-01	0.976	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	1.056817e-01	0.976	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	1.061810e-01	0.974	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	1.096621e-01	0.960	0	0
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	1.096621e-01	0.960	0	0
Lipophagy	R-HSA-9613354	1.113213e-01	0.953	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.113213e-01	0.953	0	0
GP1b-IX-V activation signalling	R-HSA-430116	1.113213e-01	0.953	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	1.113213e-01	0.953	0	0
Cellular response to mitochondrial stress	R-HSA-9840373	1.113213e-01	0.953	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	1.113213e-01	0.953	0	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	1.121289e-01	0.950	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	1.121289e-01	0.950	0	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	1.121289e-01	0.950	0	0
Regulation of RAS by GAPs	R-HSA-5658442	1.133728e-01	0.945	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	1.138554e-01	0.944	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	1.143963e-01	0.942	0	0
AKT-mediated inactivation of FOXO1A	R-HSA-211163	1.148969e-01	0.940	0	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	1.148969e-01	0.940	0	0
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	1.148969e-01	0.940	0	0
MTF1 activates gene expression	R-HSA-5660489	1.148969e-01	0.940	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	1.151334e-01	0.939	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	1.157353e-01	0.937	1	1
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	1.157353e-01	0.937	0	0
Regulation of Apoptosis	R-HSA-169911	1.157353e-01	0.937	0	0
Generic Transcription Pathway	R-HSA-212436	1.199579e-01	0.921	1	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	1.201861e-01	0.920	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	1.220735e-01	0.913	0	0
Assembly Of The HIV Virion	R-HSA-175474	1.229661e-01	0.910	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	1.246681e-01	0.904	0	0
Signaling by FGFR4	R-HSA-5654743	1.246681e-01	0.904	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	1.261536e-01	0.899	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	1.261536e-01	0.899	0	0
DARPP-32 events	R-HSA-180024	1.261536e-01	0.899	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	1.261536e-01	0.899	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	1.261536e-01	0.899	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	1.262684e-01	0.899	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	1.271977e-01	0.896	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	1.271977e-01	0.896	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	1.271977e-01	0.896	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	1.271977e-01	0.896	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	1.271977e-01	0.896	0	0
Prolonged ERK activation events	R-HSA-169893	1.301528e-01	0.886	0	0
Regulation of BACH1 activity	R-HSA-9708530	1.301528e-01	0.886	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	1.311235e-01	0.882	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	1.311235e-01	0.882	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	1.323031e-01	0.878	0	0
Signal attenuation	R-HSA-74749	1.323031e-01	0.878	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.323031e-01	0.878	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.754317e-01	0.756	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.754317e-01	0.756	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	1.754317e-01	0.756	0	0
TICAM1 deficiency - HSE	R-HSA-5602566	1.754317e-01	0.756	0	0
Defective Mismatch Repair Associated With PMS2	R-HSA-5632987	1.754317e-01	0.756	0	0
Defective Mismatch Repair Associated With MLH1	R-HSA-5545483	1.754317e-01	0.756	0	0
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	1.754317e-01	0.756	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.754317e-01	0.756	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.754317e-01	0.756	0	0
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	1.754317e-01	0.756	0	0
Interactions of Tat with host cellular proteins	R-HSA-176034	2.512513e-01	0.600	0	0
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	2.512513e-01	0.600	0	0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5619101	2.512513e-01	0.600	0	0
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	2.512513e-01	0.600	0	0
PTEN Loss of Function in Cancer	R-HSA-5674404	2.512513e-01	0.600	0	0
Signaling by TCF7L2 mutants	R-HSA-5339700	2.512513e-01	0.600	0	0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5660686	2.512513e-01	0.600	0	0
TRAF3 deficiency - HSE	R-HSA-5602571	2.512513e-01	0.600	0	0
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.512513e-01	0.600	0	0
Defective GFPT1 causes CMSTA1	R-HSA-4085023	2.512513e-01	0.600	0	0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.512513e-01	0.600	0	0
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	2.512513e-01	0.600	0	0
Intestinal infectious diseases	R-HSA-8942233	2.512513e-01	0.600	0	0
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	1.471702e-01	0.832	0	0
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	1.471702e-01	0.832	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	1.471702e-01	0.832	0	0
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	1.471702e-01	0.832	0	0
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	1.471702e-01	0.832	0	0
PKB-mediated events	R-HSA-109703	1.809934e-01	0.742	0	0
PDE3B signalling	R-HSA-165160	1.809934e-01	0.742	0	0
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	1.809934e-01	0.742	0	0
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	2.158091e-01	0.666	0	0
SOS-mediated signalling	R-HSA-112412	2.511494e-01	0.600	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	2.511494e-01	0.600	0	0
Disinhibition of SNARE formation	R-HSA-114516	2.511494e-01	0.600	0	0
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	2.511494e-01	0.600	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	2.019810e-01	0.695	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	2.019810e-01	0.695	0	0
FGFR2 alternative splicing	R-HSA-6803529	1.369782e-01	0.863	0	0
Notch-HLH transcription pathway	R-HSA-350054	1.369782e-01	0.863	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	2.268503e-01	0.644	0	0
GAB1 signalosome	R-HSA-180292	1.841192e-01	0.735	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	1.384715e-01	0.859	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	1.669627e-01	0.777	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	2.035233e-01	0.691	0	0
Cristae formation	R-HSA-8949613	2.161422e-01	0.665	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	1.556230e-01	0.808	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	2.647801e-01	0.577	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	2.647801e-01	0.577	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	1.405154e-01	0.852	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	1.405154e-01	0.852	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	1.666846e-01	0.778	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	1.602905e-01	0.795	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	2.511420e-01	0.600	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	1.706537e-01	0.768	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	1.706537e-01	0.768	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	2.397810e-01	0.620	1	1
Nucleotide Excision Repair	R-HSA-5696398	1.666040e-01	0.778	0	0
Sensing of DNA Double Strand Breaks	R-HSA-5693548	1.778155e-01	0.750	0	0
Activation of the pre-replicative complex	R-HSA-68962	1.384715e-01	0.859	0	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	2.158091e-01	0.666	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	1.384715e-01	0.859	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	1.346020e-01	0.871	0	0
Ca2+ pathway	R-HSA-4086398	1.653586e-01	0.782	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	1.785323e-01	0.748	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	2.257542e-01	0.646	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	1.666846e-01	0.778	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	1.745910e-01	0.758	0	0
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	1.809934e-01	0.742	0	0
CREB phosphorylation	R-HSA-199920	2.158091e-01	0.666	0	0
Budding and maturation of HIV virion	R-HSA-162588	1.513256e-01	0.820	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.898370e-01	0.722	0	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	1.928244e-01	0.715	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	2.397810e-01	0.620	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	2.226229e-01	0.652	0	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	1.828444e-01	0.738	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	1.563741e-01	0.806	0	0
Fanconi Anemia Pathway	R-HSA-6783310	1.449243e-01	0.839	0	0
Intraflagellar transport	R-HSA-5620924	1.780946e-01	0.749	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	1.986321e-01	0.702	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	2.120333e-01	0.674	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	2.142509e-01	0.669	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	1.999813e-01	0.699	0	0
RAF/MAP kinase cascade	R-HSA-5673001	1.462851e-01	0.835	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	1.873160e-01	0.727	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	1.775789e-01	0.751	0	0
Toll-like Receptor Cascades	R-HSA-168898	2.284711e-01	0.641	0	0
Signal transduction by L1	R-HSA-445144	2.234921e-01	0.651	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	1.928244e-01	0.715	0	0
Opioid Signalling	R-HSA-111885	1.518647e-01	0.819	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	1.934630e-01	0.713	0	0
Frs2-mediated activation	R-HSA-170968	2.268503e-01	0.644	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	2.199738e-01	0.658	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	1.623746e-01	0.789	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	1.809934e-01	0.742	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	2.540626e-01	0.595	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	1.981740e-01	0.703	0	0
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	1.471702e-01	0.832	0	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	2.158091e-01	0.666	0	0
Degradation of DVL	R-HSA-4641258	1.372673e-01	0.862	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	1.449243e-01	0.839	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	1.928244e-01	0.715	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	2.416850e-01	0.617	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	1.391755e-01	0.856	0	0
Regulated Necrosis	R-HSA-5218859	2.039948e-01	0.690	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	1.986321e-01	0.702	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	1.449243e-01	0.839	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	1.666846e-01	0.778	0	0
Translation	R-HSA-72766	1.728724e-01	0.762	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	1.591956e-01	0.798	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	2.323004e-01	0.634	0	0
Formation of editosomes by ADAR proteins	R-HSA-77042	1.754317e-01	0.756	0	0
Inhibition of PKR	R-HSA-169131	1.754317e-01	0.756	0	0
Inhibition of Host mRNA Processing and RNA Silencing	R-HSA-168315	2.512513e-01	0.600	0	0
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	1.471702e-01	0.832	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	1.516584e-01	0.819	0	0
Regulation of KIT signaling	R-HSA-1433559	2.522563e-01	0.598	0	0
Degradation of AXIN	R-HSA-4641257	1.372673e-01	0.862	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	1.372673e-01	0.862	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	1.449243e-01	0.839	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	2.075326e-01	0.683	0	0
RMTs methylate histone arginines	R-HSA-3214858	2.397742e-01	0.620	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	2.529161e-01	0.597	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	2.387180e-01	0.622	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	1.900301e-01	0.721	0	0
EPH-Ephrin signaling	R-HSA-2682334	1.926256e-01	0.715	0	0
Synthesis of DNA	R-HSA-69239	1.820509e-01	0.740	0	0
TCR signaling	R-HSA-202403	1.383004e-01	0.859	0	0
MAP kinase activation	R-HSA-450294	1.358039e-01	0.867	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	1.785323e-01	0.748	0	0
Transmission across Chemical Synapses	R-HSA-112315	2.152387e-01	0.667	0	0
Hedgehog 'on' state	R-HSA-5632684	2.369580e-01	0.625	0	0
Regulation of pyruvate metabolism	R-HSA-9861718	1.556230e-01	0.808	0	0
Interleukin-1 family signaling	R-HSA-446652	2.153233e-01	0.667	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	2.593716e-01	0.586	0	0
Signaling by MET	R-HSA-6806834	1.496341e-01	0.825	0	0
PECAM1 interactions	R-HSA-210990	1.545292e-01	0.811	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	1.605973e-01	0.794	0	0
Interleukin-17 signaling	R-HSA-448424	2.257542e-01	0.646	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	1.487162e-01	0.828	0	0
G1/S Transition	R-HSA-69206	1.382690e-01	0.859	0	0
RSV-host interactions	R-HSA-9833110	1.591441e-01	0.798	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	1.572749e-01	0.803	0	0
Protein hydroxylation	R-HSA-9629569	2.234921e-01	0.651	0	0
DNA strand elongation	R-HSA-69190	1.646890e-01	0.783	0	0
Basigin interactions	R-HSA-210991	2.439394e-01	0.613	0	0
Signaling by FGFR3	R-HSA-5654741	1.449243e-01	0.839	0	0
Adaptive Immune System	R-HSA-1280218	1.635583e-01	0.786	0	0
Signaling by FGFR	R-HSA-190236	2.587668e-01	0.587	0	0
Integration of provirus	R-HSA-162592	1.778155e-01	0.750	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	1.369782e-01	0.863	0	0
Hemostasis	R-HSA-109582	1.790821e-01	0.747	0	0
Semaphorin interactions	R-HSA-373755	1.539078e-01	0.813	0	0
Breakdown of the nuclear lamina	R-HSA-352238	2.512513e-01	0.600	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	2.522563e-01	0.598	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	1.449243e-01	0.839	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	1.855769e-01	0.731	0	0
Signaling by NTRKs	R-HSA-166520	1.873160e-01	0.727	0	0
Pyruvate metabolism	R-HSA-70268	2.222227e-01	0.653	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	2.234921e-01	0.651	0	0
Infectious disease	R-HSA-5663205	2.184167e-01	0.661	0	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	2.522563e-01	0.598	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	2.161422e-01	0.665	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	2.268859e-01	0.644	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	2.511494e-01	0.600	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	2.511494e-01	0.600	0	0
Plasma lipoprotein clearance	R-HSA-8964043	1.605973e-01	0.794	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	2.647801e-01	0.577	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	1.706537e-01	0.768	0	0
ChREBP activates metabolic gene expression	R-HSA-163765	1.545292e-01	0.811	0	0
MITF-M-dependent gene expression	R-HSA-9856651	2.010831e-01	0.697	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	1.855769e-01	0.731	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	1.369782e-01	0.863	0	0
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	2.234921e-01	0.651	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	2.540626e-01	0.595	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	2.540626e-01	0.595	0	0
Suppression of phagosomal maturation	R-HSA-9637687	1.992545e-01	0.701	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	2.075326e-01	0.683	0	0
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	2.439394e-01	0.613	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	2.511420e-01	0.600	0	0
Translation of Structural Proteins	R-HSA-9683701	1.986321e-01	0.702	0	0
HDL assembly	R-HSA-8963896	2.522563e-01	0.598	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	2.439394e-01	0.613	0	0
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	2.647801e-01	0.577	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	2.685943e-01	0.571	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	2.691489e-01	0.570	0	0
Activation of BH3-only proteins	R-HSA-114452	2.691489e-01	0.570	0	0
Cellular response to hypoxia	R-HSA-1234174	2.758837e-01	0.559	0	0
Signaling by TGFB family members	R-HSA-9006936	2.765166e-01	0.558	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	2.780409e-01	0.556	0	0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	2.780409e-01	0.556	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	2.780409e-01	0.556	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	2.780409e-01	0.556	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	2.780409e-01	0.556	0	0
ABC-family proteins mediated transport	R-HSA-382556	2.790229e-01	0.554	0	0
Signaling by FGFR1	R-HSA-5654736	2.798248e-01	0.553	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	2.860940e-01	0.543	0	0
RAS processing	R-HSA-9648002	2.860940e-01	0.543	0	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	2.866238e-01	0.543	0	0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	2.866238e-01	0.543	0	0
MET receptor recycling	R-HSA-8875656	2.866238e-01	0.543	0	0
Adrenoceptors	R-HSA-390696	2.866238e-01	0.543	0	0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	2.866238e-01	0.543	0	0
TGFBR3 PTM regulation	R-HSA-9839383	2.866238e-01	0.543	0	0
Sodium/Proton exchangers	R-HSA-425986	2.866238e-01	0.543	0	0
Trafficking of AMPA receptors	R-HSA-399719	2.874239e-01	0.541	0	0
Protein-protein interactions at synapses	R-HSA-6794362	2.899972e-01	0.538	0	0
Signaling by NOTCH1	R-HSA-1980143	2.957006e-01	0.529	0	0
GPER1 signaling	R-HSA-9634597	2.982800e-01	0.525	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	3.025582e-01	0.519	0	0
Diseases of Immune System	R-HSA-5260271	3.025582e-01	0.519	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	3.025582e-01	0.519	0	0
Class I peroxisomal membrane protein import	R-HSA-9603798	3.040571e-01	0.517	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	3.040571e-01	0.517	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	3.040571e-01	0.517	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	3.040571e-01	0.517	0	0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	3.040571e-01	0.517	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	3.040571e-01	0.517	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	3.068145e-01	0.513	0	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	3.068145e-01	0.513	0	0
Inositol phosphate metabolism	R-HSA-1483249	3.136941e-01	0.503	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	3.145606e-01	0.502	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	3.191885e-01	0.496	0	0
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	3.201034e-01	0.495	0	0
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	3.201034e-01	0.495	0	0
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.201034e-01	0.495	0	0
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	3.201034e-01	0.495	0	0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.201034e-01	0.495	0	0
Defective AHCY causes HMAHCHD	R-HSA-5578997	3.201034e-01	0.495	0	0
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.201034e-01	0.495	0	0
mRNA Editing: A to I Conversion	R-HSA-75064	3.201034e-01	0.495	0	0
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	3.201034e-01	0.495	0	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	3.201034e-01	0.495	0	0
C6 deamination of adenosine	R-HSA-75102	3.201034e-01	0.495	0	0
Interleukin-33 signaling	R-HSA-9014843	3.201034e-01	0.495	0	0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis	R-HSA-9708296	3.201034e-01	0.495	0	0
ATF6B (ATF6-beta) activates chaperones	R-HSA-8874177	3.201034e-01	0.495	0	0
ARMS-mediated activation	R-HSA-170984	3.219091e-01	0.492	0	0
5-Phosphoribose 1-diphosphate biosynthesis	R-HSA-73843	3.219091e-01	0.492	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	3.219091e-01	0.492	0	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	3.219091e-01	0.492	0	0
Regulation of CDH11 gene transcription	R-HSA-9762293	3.219091e-01	0.492	0	0
Interleukin-1 processing	R-HSA-448706	3.219091e-01	0.492	0	0
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	3.219091e-01	0.492	0	0
Respiratory syncytial virus genome replication	R-HSA-9834752	3.219091e-01	0.492	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	3.245720e-01	0.489	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	3.245720e-01	0.489	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	3.245720e-01	0.489	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	3.245720e-01	0.489	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	3.245720e-01	0.489	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	3.245720e-01	0.489	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	3.286065e-01	0.483	0	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	3.288447e-01	0.483	0	0
Plasma lipoprotein assembly	R-HSA-8963898	3.288447e-01	0.483	0	0
G beta:gamma signalling through CDC42	R-HSA-8964616	3.301688e-01	0.481	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	3.301688e-01	0.481	0	0
Disorders of Developmental Biology	R-HSA-9675151	3.301688e-01	0.481	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	3.320212e-01	0.479	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	3.359493e-01	0.474	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	3.363807e-01	0.473	0	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	3.363807e-01	0.473	0	0
Cardiac conduction	R-HSA-5576891	3.478667e-01	0.459	0	0
ER-Phagosome pathway	R-HSA-1236974	3.484558e-01	0.458	0	0
Aquaporin-mediated transport	R-HSA-445717	3.498416e-01	0.456	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	3.498416e-01	0.456	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	3.498416e-01	0.456	0	0
HDMs demethylate histones	R-HSA-3214842	3.504563e-01	0.455	0	0
Platelet homeostasis	R-HSA-418346	3.532690e-01	0.452	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	3.542894e-01	0.451	1	0
Regulation of mitotic cell cycle	R-HSA-453276	3.542894e-01	0.451	1	0
PI3K events in ERBB2 signaling	R-HSA-1963642	3.562516e-01	0.448	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	3.562516e-01	0.448	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	3.562516e-01	0.448	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	3.562516e-01	0.448	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	3.562516e-01	0.448	0	0
Signaling by Hippo	R-HSA-2028269	3.562516e-01	0.448	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	3.562516e-01	0.448	0	0
Formation of the cornified envelope	R-HSA-6809371	3.564331e-01	0.448	0	0
Binding and entry of HIV virion	R-HSA-173107	3.567403e-01	0.448	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	3.567403e-01	0.448	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	3.567403e-01	0.448	0	0
2-LTR circle formation	R-HSA-164843	3.567403e-01	0.448	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	3.567403e-01	0.448	0	0
PI3K/AKT activation	R-HSA-198203	3.567403e-01	0.448	0	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	3.567403e-01	0.448	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	3.567403e-01	0.448	0	0
Signaling by Leptin	R-HSA-2586552	3.567403e-01	0.448	0	0
Downstream TCR signaling	R-HSA-202424	3.603994e-01	0.443	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	3.621865e-01	0.441	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	3.621865e-01	0.441	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	3.621865e-01	0.441	0	0
Calnexin/calreticulin cycle	R-HSA-901042	3.621865e-01	0.441	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	3.676863e-01	0.435	0	0
Signalling to ERKs	R-HSA-187687	3.810505e-01	0.419	0	0
PERK regulates gene expression	R-HSA-381042	3.810505e-01	0.419	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	3.810505e-01	0.419	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	3.810505e-01	0.419	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	3.821928e-01	0.418	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	3.821928e-01	0.418	0	0
Ephrin signaling	R-HSA-3928664	3.821928e-01	0.418	0	0
Mismatch Repair	R-HSA-5358508	3.821928e-01	0.418	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	3.821928e-01	0.418	0	0
Platelet sensitization by LDL	R-HSA-432142	3.821928e-01	0.418	0	0
PLC-gamma1 signalling	R-HSA-167021	3.826278e-01	0.417	0	0
Activated NTRK3 signals through PLCG1	R-HSA-9034793	3.826278e-01	0.417	0	0
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	3.826278e-01	0.417	0	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	3.826278e-01	0.417	0	0
MET activates PTPN11	R-HSA-8865999	3.826278e-01	0.417	0	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	3.826278e-01	0.417	0	0
Classical Kir channels	R-HSA-1296053	3.826278e-01	0.417	0	0
STAT6-mediated induction of chemokines	R-HSA-3249367	3.826278e-01	0.417	0	0
MET interacts with TNS proteins	R-HSA-8875513	3.826278e-01	0.417	0	0
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	3.826278e-01	0.417	0	0
CASP5-mediated substrate cleavage	R-HSA-9960525	3.826278e-01	0.417	0	0
CASP4-mediated substrate cleavage	R-HSA-9960519	3.826278e-01	0.417	0	0
Cyclin D associated events in G1	R-HSA-69231	3.866695e-01	0.413	0	0
G1 Phase	R-HSA-69236	3.866695e-01	0.413	0	0
Netrin-1 signaling	R-HSA-373752	3.866695e-01	0.413	0	0
Suppression of apoptosis	R-HSA-9635465	3.909028e-01	0.408	0	0
Ion transport by P-type ATPases	R-HSA-936837	3.928937e-01	0.406	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	3.928937e-01	0.406	0	0
ER Quality Control Compartment (ERQC)	R-HSA-901032	3.936407e-01	0.405	0	0
Insulin processing	R-HSA-264876	3.936407e-01	0.405	0	0
Signaling by FGFR in disease	R-HSA-1226099	3.946101e-01	0.404	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	3.965173e-01	0.402	0	0
Triglyceride catabolism	R-HSA-163560	3.998931e-01	0.398	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	4.007660e-01	0.397	0	0
G alpha (z) signalling events	R-HSA-418597	4.058981e-01	0.392	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	4.078911e-01	0.389	0	0
Specification of the neural plate border	R-HSA-9834899	4.078911e-01	0.389	0	0
The NLRP3 inflammasome	R-HSA-844456	4.078911e-01	0.389	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	4.078911e-01	0.389	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	4.081042e-01	0.389	0	0
Iron uptake and transport	R-HSA-917937	4.081042e-01	0.389	0	0
Neuronal System	R-HSA-112316	4.127966e-01	0.384	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	4.150872e-01	0.382	0	0
Formation of the Early Elongation Complex	R-HSA-113418	4.150872e-01	0.382	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	4.150872e-01	0.382	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	4.205196e-01	0.376	0	0
Diseases of DNA repair	R-HSA-9675135	4.205196e-01	0.376	0	0
Signaling by TGFBR3	R-HSA-9839373	4.205196e-01	0.376	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	4.212481e-01	0.375	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	4.212481e-01	0.375	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	4.213995e-01	0.375	0	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	4.242251e-01	0.372	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	4.242251e-01	0.372	0	0
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	4.242251e-01	0.372	0	0
Sodium/Calcium exchangers	R-HSA-425561	4.242251e-01	0.372	0	0
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	4.242251e-01	0.372	0	0
Signaling by Interleukins	R-HSA-449147	4.308047e-01	0.366	0	0
Co-inhibition by CTLA4	R-HSA-389513	4.332566e-01	0.363	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	4.332566e-01	0.363	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	4.332566e-01	0.363	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	4.332566e-01	0.363	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	4.332566e-01	0.363	0	0
Signaling by NODAL	R-HSA-1181150	4.332566e-01	0.363	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.334330e-01	0.363	0	0
Signaling by Erythropoietin	R-HSA-9006335	4.363595e-01	0.360	0	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	4.363595e-01	0.360	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	4.373495e-01	0.359	0	0
HCN channels	R-HSA-1296061	4.394057e-01	0.357	0	0
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	4.394057e-01	0.357	0	0
Activated NTRK2 signals through PLCG1	R-HSA-9026527	4.394057e-01	0.357	0	0
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	4.394057e-01	0.357	0	0
Signaling by MAP2K mutants	R-HSA-9652169	4.394057e-01	0.357	0	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	4.394057e-01	0.357	0	0
Defective LFNG causes SCDO3	R-HSA-5083630	4.394057e-01	0.357	0	0
Regulation of gap junction activity	R-HSA-191650	4.394057e-01	0.357	0	0
TNFR1-mediated ceramide production	R-HSA-5626978	4.394057e-01	0.357	0	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	4.394057e-01	0.357	0	0
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	4.394057e-01	0.357	0	0
Sensory perception of sour taste	R-HSA-9729555	4.394057e-01	0.357	0	0
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	4.394057e-01	0.357	0	0
Dual incision in TC-NER	R-HSA-6782135	4.522575e-01	0.345	0	0
NGF-stimulated transcription	R-HSA-9031628	4.541151e-01	0.343	0	0
Metal ion SLC transporters	R-HSA-425410	4.541151e-01	0.343	0	0
Potential therapeutics for SARS	R-HSA-9679191	4.541952e-01	0.343	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	4.558867e-01	0.341	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	4.558867e-01	0.341	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	4.558867e-01	0.341	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	4.565729e-01	0.340	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	4.565729e-01	0.340	0	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	4.565729e-01	0.340	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	4.565729e-01	0.340	0	0
Defective EXT2 causes exostoses 2	R-HSA-3656237	4.565729e-01	0.340	0	0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	R-HSA-3656253	4.565729e-01	0.340	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	4.565729e-01	0.340	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	4.565729e-01	0.340	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	4.565729e-01	0.340	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	4.565729e-01	0.340	0	0
Role of second messengers in netrin-1 signaling	R-HSA-418890	4.565729e-01	0.340	0	0
Pervasive developmental disorders	R-HSA-9005895	4.565729e-01	0.340	0	0
Disorders of Nervous System Development	R-HSA-9697154	4.565729e-01	0.340	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	4.565729e-01	0.340	0	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	4.582100e-01	0.339	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	4.582100e-01	0.339	0	0
Sensory processing of sound	R-HSA-9659379	4.619282e-01	0.335	0	0
Triglyceride metabolism	R-HSA-8979227	4.675708e-01	0.330	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	4.707480e-01	0.327	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	4.733804e-01	0.325	0	0
HIV Transcription Elongation	R-HSA-167169	4.742498e-01	0.324	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	4.742498e-01	0.324	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	4.742498e-01	0.324	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	4.742498e-01	0.324	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	4.742498e-01	0.324	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	4.781795e-01	0.320	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	4.826824e-01	0.316	0	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	4.826824e-01	0.316	0	0
Attachment and Entry	R-HSA-9694614	4.826824e-01	0.316	0	0
PI3K Cascade	R-HSA-109704	4.872371e-01	0.312	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	4.878437e-01	0.312	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	4.878437e-01	0.312	0	0
Platelet Adhesion to exposed collagen	R-HSA-75892	4.878437e-01	0.312	0	0
Maturation of nucleoprotein	R-HSA-9683610	4.878437e-01	0.312	0	0
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	4.878437e-01	0.312	0	0
Antigen processing-Cross presentation	R-HSA-1236975	4.890586e-01	0.311	0	0
Stimuli-sensing channels	R-HSA-2672351	4.890586e-01	0.311	0	0
Activation of AMPA receptors	R-HSA-399710	4.909649e-01	0.309	0	0
SMAC (DIABLO) binds to IAPs	R-HSA-111463	4.909649e-01	0.309	0	0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	4.909649e-01	0.309	0	0
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	4.909649e-01	0.309	0	0
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	4.909649e-01	0.309	0	0
Defective F9 activation	R-HSA-9673221	4.909649e-01	0.309	0	0
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	4.909649e-01	0.309	0	0
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	4.909649e-01	0.309	0	0
Activation of AKT2	R-HSA-165158	4.909649e-01	0.309	0	0
Reelin signalling pathway	R-HSA-8866376	4.909649e-01	0.309	0	0
Suppression of autophagy	R-HSA-9636569	4.909649e-01	0.309	0	0
Muscarinic acetylcholine receptors	R-HSA-390648	4.909649e-01	0.309	0	0
Nectin/Necl trans heterodimerization	R-HSA-420597	4.909649e-01	0.309	0	0
Interleukin-36 pathway	R-HSA-9014826	4.909649e-01	0.309	0	0
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	4.909649e-01	0.309	0	0
Zinc efflux and compartmentalization by the SLC30 family	R-HSA-435368	4.909649e-01	0.309	0	0
Immune System	R-HSA-168256	4.933874e-01	0.307	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	4.978643e-01	0.303	0	0
Signaling by WNT in cancer	R-HSA-4791275	4.986370e-01	0.302	0	0
Integration of energy metabolism	R-HSA-163685	5.094939e-01	0.293	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	5.103275e-01	0.292	0	0
Retrograde neurotrophin signalling	R-HSA-177504	5.179620e-01	0.286	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	5.179620e-01	0.286	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	5.179620e-01	0.286	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	5.179620e-01	0.286	0	0
Physiological factors	R-HSA-5578768	5.179620e-01	0.286	0	0
Non-canonical inflammasome activation	R-HSA-9686114	5.179620e-01	0.286	0	0
Zinc transporters	R-HSA-435354	5.179620e-01	0.286	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	5.181082e-01	0.286	0	0
G-protein beta:gamma signalling	R-HSA-397795	5.187405e-01	0.285	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	5.187405e-01	0.285	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	5.196912e-01	0.284	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	5.275909e-01	0.278	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	5.299564e-01	0.276	0	0
Ion channel transport	R-HSA-983712	5.356635e-01	0.271	0	0
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	5.377849e-01	0.269	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	5.377849e-01	0.269	0	0
Plus-strand DNA synthesis	R-HSA-164525	5.377849e-01	0.269	0	0
PTK6 Regulates Cell Cycle	R-HSA-8849470	5.377849e-01	0.269	0	0
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	5.377849e-01	0.269	0	0
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	5.377849e-01	0.269	0	0
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	5.377849e-01	0.269	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	5.377849e-01	0.269	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	5.377849e-01	0.269	0	0
Loss-of-function mutations in DLD cause MSUD3/DLDD	R-HSA-9907570	5.377849e-01	0.269	0	0
Signaling by RNF43 mutants	R-HSA-5340588	5.377849e-01	0.269	0	0
Loss-of-function mutations in DBT cause MSUD2	R-HSA-9865113	5.377849e-01	0.269	0	0
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	5.377849e-01	0.269	0	0
Cam-PDE 1 activation	R-HSA-111957	5.377849e-01	0.269	0	0
CDC6 association with the ORC:origin complex	R-HSA-68689	5.377849e-01	0.269	0	0
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	5.377849e-01	0.269	0	0
Signalling to p38 via RIT and RIN	R-HSA-187706	5.377849e-01	0.269	0	0
Release of apoptotic factors from the mitochondria	R-HSA-111457	5.377849e-01	0.269	0	0
CLEC7A/inflammasome pathway	R-HSA-5660668	5.377849e-01	0.269	0	0
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	5.377849e-01	0.269	0	0
Resolution of D-Loop Structures	R-HSA-5693537	5.384558e-01	0.269	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	5.384558e-01	0.269	0	0
Insulin receptor signalling cascade	R-HSA-74751	5.421994e-01	0.266	0	0
IGF1R signaling cascade	R-HSA-2428924	5.421994e-01	0.266	0	0
Erythropoietin activates RAS	R-HSA-9027284	5.468753e-01	0.262	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	5.468753e-01	0.262	0	0
G beta:gamma signalling through BTK	R-HSA-8964315	5.468753e-01	0.262	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	5.468753e-01	0.262	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	5.468753e-01	0.262	0	0
Processive synthesis on the lagging strand	R-HSA-69183	5.468753e-01	0.262	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	5.468753e-01	0.262	0	0
Biotin transport and metabolism	R-HSA-196780	5.468753e-01	0.262	0	0
DCC mediated attractive signaling	R-HSA-418885	5.468753e-01	0.262	0	0
Deadenylation of mRNA	R-HSA-429947	5.526664e-01	0.258	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	5.566177e-01	0.254	0	0
Signal amplification	R-HSA-392518	5.577534e-01	0.254	0	0
RA biosynthesis pathway	R-HSA-5365859	5.577534e-01	0.254	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	5.606159e-01	0.251	0	0
EPHB-mediated forward signaling	R-HSA-3928662	5.624160e-01	0.250	0	0
Defective GALNT12 causes CRCS1	R-HSA-5083636	5.745506e-01	0.241	0	0
Defective GALNT3 causes HFTC	R-HSA-5083625	5.745506e-01	0.241	0	0
Differentiation of T cells	R-HSA-9945266	5.745506e-01	0.241	0	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	5.745506e-01	0.241	0	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	5.745506e-01	0.241	0	0
Translation of Structural Proteins	R-HSA-9694635	5.746874e-01	0.241	0	0
Long-term potentiation	R-HSA-9620244	5.747108e-01	0.241	0	0
Activation of G protein gated Potassium channels	R-HSA-1296041	5.747108e-01	0.241	0	0
G protein gated Potassium channels	R-HSA-1296059	5.747108e-01	0.241	0	0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	5.747108e-01	0.241	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	5.747108e-01	0.241	0	0
Tight junction interactions	R-HSA-420029	5.747108e-01	0.241	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	5.747108e-01	0.241	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	5.747108e-01	0.241	0	0
TGFBR3 expression	R-HSA-9839394	5.747108e-01	0.241	0	0
Formation of the nephric duct	R-HSA-9830364	5.747108e-01	0.241	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	5.791468e-01	0.237	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	5.803010e-01	0.236	0	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	5.803010e-01	0.236	0	0
Erythropoietin activates STAT5	R-HSA-9027283	5.803010e-01	0.236	0	0
STAT5 Activation	R-HSA-9645135	5.803010e-01	0.236	0	0
Uncoating of the HIV Virion	R-HSA-162585	5.803010e-01	0.236	0	0
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	5.803010e-01	0.236	0	0
H139Hfs13* PPM1K causes a mild variant of MSUD	R-HSA-9912529	5.803010e-01	0.236	0	0
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	5.803010e-01	0.236	0	0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD	R-HSA-9865125	5.803010e-01	0.236	0	0
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	5.803010e-01	0.236	0	0
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	5.803010e-01	0.236	0	0
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	5.803010e-01	0.236	0	0
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	5.803010e-01	0.236	0	0
Abacavir transmembrane transport	R-HSA-2161517	5.803010e-01	0.236	0	0
HDL clearance	R-HSA-8964011	5.803010e-01	0.236	0	0
Nef and signal transduction	R-HSA-164944	5.803010e-01	0.236	0	0
VLDL assembly	R-HSA-8866423	5.803010e-01	0.236	0	0
Neurofascin interactions	R-HSA-447043	5.803010e-01	0.236	0	0
ABC transporter disorders	R-HSA-5619084	5.877329e-01	0.231	0	0
RUNX2 regulates bone development	R-HSA-8941326	5.949956e-01	0.225	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	5.955304e-01	0.225	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	5.960628e-01	0.225	0	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	5.960628e-01	0.225	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	5.960628e-01	0.225	0	0
IRS-mediated signalling	R-HSA-112399	5.968530e-01	0.224	0	0
Transcription of the HIV genome	R-HSA-167172	5.985990e-01	0.223	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	6.009708e-01	0.221	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	6.009708e-01	0.221	0	0
Defective B4GALT7 causes EDS, progeroid type	R-HSA-3560783	6.009708e-01	0.221	0	0
Defective B3GALT6 causes EDSP2 and SEMDJL1	R-HSA-4420332	6.009708e-01	0.221	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	6.009708e-01	0.221	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	6.009708e-01	0.221	0	0
Coenzyme A biosynthesis	R-HSA-196783	6.009708e-01	0.221	0	0
Response to metal ions	R-HSA-5660526	6.009708e-01	0.221	0	0
Regulation of insulin secretion	R-HSA-422356	6.048992e-01	0.218	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	6.167025e-01	0.210	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	6.167025e-01	0.210	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	6.167025e-01	0.210	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	6.167025e-01	0.210	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	6.167025e-01	0.210	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	6.167025e-01	0.210	0	0
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	6.189086e-01	0.208	0	0
MET activates PI3K/AKT signaling	R-HSA-8851907	6.189086e-01	0.208	0	0
NOSTRIN mediated eNOS trafficking	R-HSA-203641	6.189086e-01	0.208	0	0
TRIF-mediated programmed cell death	R-HSA-2562578	6.189086e-01	0.208	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	6.189086e-01	0.208	0	0
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	6.189086e-01	0.208	0	0
Recycling of eIF2:GDP	R-HSA-72731	6.189086e-01	0.208	0	0
PTK6 Expression	R-HSA-8849473	6.189086e-01	0.208	0	0
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	6.189086e-01	0.208	0	0
Activated NTRK2 signals through CDK5	R-HSA-9032845	6.189086e-01	0.208	0	0
Cysteine formation from homocysteine	R-HSA-1614603	6.189086e-01	0.208	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	6.189086e-01	0.208	0	0
LDL remodeling	R-HSA-8964041	6.189086e-01	0.208	0	0
VLDL clearance	R-HSA-8964046	6.189086e-01	0.208	0	0
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	6.189086e-01	0.208	0	0
CHL1 interactions	R-HSA-447041	6.189086e-01	0.208	0	0
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	6.189086e-01	0.208	0	0
Peroxisomal protein import	R-HSA-9033241	6.257981e-01	0.204	0	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	6.261328e-01	0.203	0	0
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	6.261328e-01	0.203	0	0
Defective B3GAT3 causes JDSSDHD	R-HSA-3560801	6.261328e-01	0.203	0	0
Specification of primordial germ cells	R-HSA-9827857	6.261328e-01	0.203	0	0
Co-stimulation by CD28	R-HSA-389356	6.271969e-01	0.203	0	0
MET promotes cell motility	R-HSA-8875878	6.303052e-01	0.200	0	0
HIV elongation arrest and recovery	R-HSA-167287	6.366157e-01	0.196	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	6.366157e-01	0.196	0	0
Insulin receptor recycling	R-HSA-77387	6.366157e-01	0.196	0	0
Pyroptosis	R-HSA-5620971	6.366157e-01	0.196	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	6.366157e-01	0.196	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	6.366157e-01	0.196	0	0
Inflammasomes	R-HSA-622312	6.366157e-01	0.196	0	0
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	6.366157e-01	0.196	0	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	6.471997e-01	0.189	0	0
Pentose phosphate pathway	R-HSA-71336	6.471997e-01	0.189	0	0
Signaling by Insulin receptor	R-HSA-74752	6.492152e-01	0.188	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	6.500445e-01	0.187	0	0
G beta:gamma signalling through PLC beta	R-HSA-418217	6.500445e-01	0.187	0	0
Apoptotic factor-mediated response	R-HSA-111471	6.500445e-01	0.187	0	0
Presynaptic function of Kainate receptors	R-HSA-500657	6.500445e-01	0.187	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	6.500445e-01	0.187	0	0
Reverse Transcription of HIV RNA	R-HSA-162589	6.539669e-01	0.184	0	0
Minus-strand DNA synthesis	R-HSA-164516	6.539669e-01	0.184	0	0
phospho-PLA2 pathway	R-HSA-111995	6.539669e-01	0.184	0	0
Activated NTRK2 signals through PI3K	R-HSA-9028335	6.539669e-01	0.184	0	0
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	6.539669e-01	0.184	0	0
Interleukin-23 signaling	R-HSA-9020933	6.539669e-01	0.184	0	0
mRNA Capping	R-HSA-72086	6.557937e-01	0.183	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	6.557937e-01	0.183	0	0
Glucagon-type ligand receptors	R-HSA-420092	6.557937e-01	0.183	0	0
Generation of second messenger molecules	R-HSA-202433	6.635745e-01	0.178	0	0
Heme signaling	R-HSA-9707616	6.668777e-01	0.176	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	6.712769e-01	0.173	0	0
The phototransduction cascade	R-HSA-2514856	6.717777e-01	0.173	0	0
Germ layer formation at gastrulation	R-HSA-9754189	6.727228e-01	0.172	0	0
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	6.727228e-01	0.172	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	6.727228e-01	0.172	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	6.727228e-01	0.172	0	0
Maturation of nucleoprotein	R-HSA-9694631	6.727228e-01	0.172	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	6.742324e-01	0.171	0	0
Interleukin-37 signaling	R-HSA-9008059	6.742324e-01	0.171	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	6.784872e-01	0.168	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	6.794235e-01	0.168	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	6.799174e-01	0.168	0	0
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	6.858018e-01	0.164	0	0
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	6.858018e-01	0.164	0	0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	6.858018e-01	0.164	0	0
mRNA Editing	R-HSA-75072	6.858018e-01	0.164	0	0
Regulation of signaling by NODAL	R-HSA-1433617	6.858018e-01	0.164	0	0
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	6.858018e-01	0.164	0	0
Defects in biotin (Btn) metabolism	R-HSA-3323169	6.858018e-01	0.164	0	0
Butyrophilin (BTN) family interactions	R-HSA-8851680	6.858018e-01	0.164	0	0
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	6.858018e-01	0.164	0	0
Neurexins and neuroligins	R-HSA-6794361	6.858284e-01	0.164	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	6.878263e-01	0.163	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	6.941923e-01	0.159	0	0
Pregnenolone biosynthesis	R-HSA-196108	6.941923e-01	0.159	0	0
Amino acids regulate mTORC1	R-HSA-9639288	6.994662e-01	0.155	0	0
Neddylation	R-HSA-8951664	7.088828e-01	0.149	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	7.088969e-01	0.149	0	0
Inwardly rectifying K+ channels	R-HSA-1296065	7.088969e-01	0.149	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	7.088969e-01	0.149	0	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	7.095322e-01	0.149	0	0
G-protein activation	R-HSA-202040	7.144835e-01	0.146	0	0
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	7.144835e-01	0.146	0	0
ERK/MAPK targets	R-HSA-198753	7.144835e-01	0.146	0	0
Lagging Strand Synthesis	R-HSA-69186	7.144835e-01	0.146	0	0
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	7.144835e-01	0.146	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	7.144835e-01	0.146	0	0
MAPK3 (ERK1) activation	R-HSA-110056	7.147097e-01	0.146	0	0
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	7.147097e-01	0.146	0	0
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	7.147097e-01	0.146	0	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	7.147097e-01	0.146	0	0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	7.147097e-01	0.146	0	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	7.147097e-01	0.146	0	0
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	7.147097e-01	0.146	0	0
CASP4 inflammasome assembly	R-HSA-9948001	7.147097e-01	0.146	0	0
Maturation of spike protein	R-HSA-9683686	7.147097e-01	0.146	0	0
Defective factor IX causes hemophilia B	R-HSA-9668250	7.147097e-01	0.146	0	0
Metal sequestration by antimicrobial proteins	R-HSA-6799990	7.147097e-01	0.146	0	0
Regulation of the apoptosome activity	R-HSA-9627069	7.147097e-01	0.146	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	7.147097e-01	0.146	0	0
Formation of apoptosome	R-HSA-111458	7.147097e-01	0.146	0	0
Mitochondrial biogenesis	R-HSA-1592230	7.165571e-01	0.145	0	0
Signaling by SCF-KIT	R-HSA-1433557	7.237913e-01	0.140	0	0
Integrin signaling	R-HSA-354192	7.251340e-01	0.140	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	7.251340e-01	0.140	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	7.326676e-01	0.135	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	7.336313e-01	0.135	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	7.336313e-01	0.135	0	0
Serine metabolism	R-HSA-977347	7.336313e-01	0.135	0	0
Signaling by PDGFR in disease	R-HSA-9671555	7.336313e-01	0.135	0	0
Gastrulation	R-HSA-9758941	7.353029e-01	0.134	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	7.409594e-01	0.130	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	7.409594e-01	0.130	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	7.409594e-01	0.130	0	0
Ionotropic activity of kainate receptors	R-HSA-451306	7.409594e-01	0.130	0	0
vRNA Synthesis	R-HSA-192814	7.409594e-01	0.130	0	0
vRNP Assembly	R-HSA-192905	7.409594e-01	0.130	0	0
Signaling by APC mutants	R-HSA-4839744	7.409594e-01	0.130	0	0
Chylomicron assembly	R-HSA-8963888	7.409594e-01	0.130	0	0
RHOBTB3 ATPase cycle	R-HSA-9706019	7.409594e-01	0.130	0	0
Bicarbonate transporters	R-HSA-425381	7.409594e-01	0.130	0	0
SARS-CoV-2 modulates autophagy	R-HSA-9754560	7.409594e-01	0.130	0	0
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	7.409594e-01	0.130	0	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	7.409594e-01	0.130	0	0
Prostanoid ligand receptors	R-HSA-391908	7.409594e-01	0.130	0	0
Transport of RCbl within the body	R-HSA-9758890	7.409594e-01	0.130	0	0
Dissolution of Fibrin Clot	R-HSA-75205	7.409594e-01	0.130	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	7.507326e-01	0.125	0	0
Somitogenesis	R-HSA-9824272	7.507326e-01	0.125	0	0
LDL clearance	R-HSA-8964038	7.516744e-01	0.124	0	0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	7.516744e-01	0.124	0	0
eNOS activation	R-HSA-203615	7.554682e-01	0.122	0	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	7.554682e-01	0.122	0	0
Adipogenesis	R-HSA-9843745	7.557838e-01	0.122	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	7.634253e-01	0.117	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	7.634253e-01	0.117	0	0
Circadian clock	R-HSA-9909396	7.635430e-01	0.117	0	0
Synthesis of diphthamide-EEF2	R-HSA-5358493	7.647953e-01	0.116	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	7.647953e-01	0.116	0	0
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	7.647953e-01	0.116	0	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	7.647953e-01	0.116	0	0
Signaling by AXIN mutants	R-HSA-4839735	7.647953e-01	0.116	0	0
Signaling by AMER1 mutants	R-HSA-4839748	7.647953e-01	0.116	0	0
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	7.647953e-01	0.116	0	0
Cytochrome c-mediated apoptotic response	R-HSA-111461	7.647953e-01	0.116	0	0
Activation of RAC1	R-HSA-428540	7.647953e-01	0.116	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	7.655926e-01	0.116	0	0
Termination of O-glycan biosynthesis	R-HSA-977068	7.686540e-01	0.114	0	0
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	7.686540e-01	0.114	0	0
Carnitine shuttle	R-HSA-200425	7.686540e-01	0.114	0	0
Growth hormone receptor signaling	R-HSA-982772	7.686540e-01	0.114	0	0
Transferrin endocytosis and recycling	R-HSA-917977	7.695927e-01	0.114	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	7.719867e-01	0.112	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	7.725836e-01	0.112	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	7.728365e-01	0.112	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	7.830433e-01	0.106	0	0
Glycosphingolipid transport	R-HSA-9845576	7.830433e-01	0.106	0	0
G1/S-Specific Transcription	R-HSA-69205	7.830433e-01	0.106	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	7.833369e-01	0.106	0	0
Mitochondrial protein degradation	R-HSA-9837999	7.833396e-01	0.106	0	0
Thromboxane signalling through TP receptor	R-HSA-428930	7.846128e-01	0.105	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	7.846128e-01	0.105	0	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	7.864392e-01	0.104	0	0
Maple Syrup Urine Disease	R-HSA-9865114	7.864392e-01	0.104	0	0
Scavenging by Class F Receptors	R-HSA-3000484	7.864392e-01	0.104	0	0
Repression of WNT target genes	R-HSA-4641265	7.864392e-01	0.104	0	0
GRB2 events in EGFR signaling	R-HSA-179812	7.864392e-01	0.104	0	0
Serotonin clearance from the synaptic cleft	R-HSA-380615	7.864392e-01	0.104	0	0
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	7.864392e-01	0.104	0	0
Signaling by LTK	R-HSA-9842663	7.864392e-01	0.104	0	0
Interleukin-15 signaling	R-HSA-8983432	7.864392e-01	0.104	0	0
OAS antiviral response	R-HSA-8983711	7.864392e-01	0.104	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	7.887597e-01	0.103	0	0
Formation of paraxial mesoderm	R-HSA-9793380	7.936922e-01	0.100	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	7.943158e-01	0.100	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	7.958381e-01	0.099	0	0
Acyl chain remodelling of PS	R-HSA-1482801	7.995949e-01	0.097	0	0
Laminin interactions	R-HSA-3000157	7.995949e-01	0.097	0	0
Interleukin-7 signaling	R-HSA-1266695	7.995949e-01	0.097	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	8.000789e-01	0.097	0	0
Disease	R-HSA-1643685	8.009119e-01	0.096	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	8.036558e-01	0.095	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	8.046272e-01	0.094	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	8.060925e-01	0.094	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	8.060925e-01	0.094	0	0
Microbial factors inhibit CASP4 activity	R-HSA-9956593	8.060925e-01	0.094	0	0
Processing of SMDT1	R-HSA-8949664	8.060925e-01	0.094	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	8.060925e-01	0.094	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	8.060925e-01	0.094	0	0
Mtb iron assimilation by chelation	R-HSA-1222449	8.060925e-01	0.094	0	0
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	8.060925e-01	0.094	0	0
Interleukin-6 signaling	R-HSA-1059683	8.060925e-01	0.094	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	8.079960e-01	0.093	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	8.091933e-01	0.092	0	0
Innate Immune System	R-HSA-168249	8.119855e-01	0.090	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	8.136450e-01	0.090	0	0
Abacavir ADME	R-HSA-2161522	8.136450e-01	0.090	0	0
TRP channels	R-HSA-3295583	8.136450e-01	0.090	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	8.136450e-01	0.090	0	0
G alpha (s) signalling events	R-HSA-418555	8.139311e-01	0.089	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	8.195369e-01	0.086	0	0
Signaling by ALK	R-HSA-201556	8.195369e-01	0.086	0	0
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	8.239383e-01	0.084	0	0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV	R-HSA-9859138	8.239383e-01	0.084	0	0
Removal of the Flap Intermediate	R-HSA-69166	8.239383e-01	0.084	0	0
cGMP effects	R-HSA-418457	8.239383e-01	0.084	0	0
Hydrolysis of LPC	R-HSA-1483115	8.239383e-01	0.084	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	8.239383e-01	0.084	0	0
Malate-aspartate shuttle	R-HSA-9856872	8.239383e-01	0.084	0	0
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.239383e-01	0.084	0	0
Signal regulatory protein family interactions	R-HSA-391160	8.239383e-01	0.084	0	0
Acyl chain remodeling of CL	R-HSA-1482798	8.239383e-01	0.084	0	0
P2Y receptors	R-HSA-417957	8.239383e-01	0.084	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	8.268075e-01	0.083	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	8.268075e-01	0.083	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	8.268075e-01	0.083	0	0
Triglyceride biosynthesis	R-HSA-75109	8.268075e-01	0.083	0	0
Maturation of hRSV A proteins	R-HSA-9828806	8.268075e-01	0.083	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	8.365903e-01	0.077	0	0
SHC1 events in EGFR signaling	R-HSA-180336	8.401426e-01	0.076	0	0
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	8.401426e-01	0.076	0	0
Telomere C-strand synthesis initiation	R-HSA-174430	8.401426e-01	0.076	0	0
Signaling by Activin	R-HSA-1502540	8.401426e-01	0.076	0	0
Transport and metabolism of PAPS	R-HSA-174362	8.401426e-01	0.076	0	0
Protein repair	R-HSA-5676934	8.401426e-01	0.076	0	0
p38MAPK events	R-HSA-171007	8.401426e-01	0.076	0	0
Lysosphingolipid and LPA receptors	R-HSA-419408	8.401426e-01	0.076	0	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	8.401426e-01	0.076	0	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	8.408514e-01	0.075	0	0
Thyroxine biosynthesis	R-HSA-209968	8.506468e-01	0.070	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	8.506468e-01	0.070	0	0
Regulation of gene expression in beta cells	R-HSA-210745	8.506468e-01	0.070	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	8.506674e-01	0.070	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	8.548564e-01	0.068	0	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	8.548564e-01	0.068	0	0
Phosphorylation of the APC/C	R-HSA-176412	8.548564e-01	0.068	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	8.548564e-01	0.068	0	0
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	8.548564e-01	0.068	0	0
Phase 4 - resting membrane potential	R-HSA-5576886	8.548564e-01	0.068	0	0
Activation of the phototransduction cascade	R-HSA-2485179	8.548564e-01	0.068	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	8.548564e-01	0.068	0	0
Fructose catabolism	R-HSA-70350	8.548564e-01	0.068	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	8.548564e-01	0.068	0	0
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	8.548564e-01	0.068	0	0
Attachment and Entry	R-HSA-9678110	8.548564e-01	0.068	0	0
Atorvastatin ADME	R-HSA-9754706	8.548564e-01	0.068	0	0
Activation of GABAB receptors	R-HSA-991365	8.599513e-01	0.066	0	0
GABA B receptor activation	R-HSA-977444	8.599513e-01	0.066	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	8.614100e-01	0.065	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	8.614100e-01	0.065	0	0
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	8.614100e-01	0.065	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.614100e-01	0.065	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	8.614100e-01	0.065	0	0
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	8.682167e-01	0.061	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	8.682167e-01	0.061	0	0
Phase 2 - plateau phase	R-HSA-5576893	8.682167e-01	0.061	0	0
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	8.682167e-01	0.061	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	8.682167e-01	0.061	0	0
Passive transport by Aquaporins	R-HSA-432047	8.682167e-01	0.061	0	0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	8.682167e-01	0.061	0	0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	8.682167e-01	0.061	0	0
Interferon gamma signaling	R-HSA-877300	8.698523e-01	0.061	0	0
tRNA processing	R-HSA-72306	8.700958e-01	0.060	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	8.712747e-01	0.060	0	0
Molecules associated with elastic fibres	R-HSA-2129379	8.714580e-01	0.060	0	0
Downstream signal transduction	R-HSA-186763	8.714580e-01	0.060	0	0
Aspartate and asparagine metabolism	R-HSA-8963693	8.714580e-01	0.060	0	0
Interferon alpha/beta signaling	R-HSA-909733	8.728006e-01	0.059	0	0
Proteasome assembly	R-HSA-9907900	8.770095e-01	0.057	0	0
Amine ligand-binding receptors	R-HSA-375280	8.770095e-01	0.057	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	8.790382e-01	0.056	0	0
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	8.803479e-01	0.055	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	8.803479e-01	0.055	0	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	8.803479e-01	0.055	0	0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	8.803479e-01	0.055	0	0
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	8.803479e-01	0.055	0	0
Catecholamine biosynthesis	R-HSA-209905	8.803479e-01	0.055	0	0
Choline catabolism	R-HSA-6798163	8.803479e-01	0.055	0	0
G0 and Early G1	R-HSA-1538133	8.808314e-01	0.055	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	8.808314e-01	0.055	0	0
HS-GAG degradation	R-HSA-2024096	8.808314e-01	0.055	0	0
Peptide hormone metabolism	R-HSA-2980736	8.832734e-01	0.054	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	8.859862e-01	0.053	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	8.895340e-01	0.051	0	0
Cardiogenesis	R-HSA-9733709	8.895691e-01	0.051	0	0
Diseases of carbohydrate metabolism	R-HSA-5663084	8.896752e-01	0.051	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	8.913631e-01	0.050	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	8.913631e-01	0.050	0	0
Polo-like kinase mediated events	R-HSA-156711	8.913631e-01	0.050	0	0
Nucleotide-like (purinergic) receptors	R-HSA-418038	8.913631e-01	0.050	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	8.913631e-01	0.050	0	0
Signaling by Retinoic Acid	R-HSA-5362517	8.925833e-01	0.049	0	0
Leishmania infection	R-HSA-9658195	8.928032e-01	0.049	0	0
Parasitic Infection Pathways	R-HSA-9824443	8.928032e-01	0.049	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	8.937989e-01	0.049	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	8.944906e-01	0.048	0	0
Disorders of transmembrane transporters	R-HSA-5619115	8.967878e-01	0.047	0	0
Protein localization	R-HSA-9609507	8.968054e-01	0.047	0	0
Acyl chain remodelling of PC	R-HSA-1482788	8.977088e-01	0.047	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	8.977088e-01	0.047	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	8.991412e-01	0.046	0	0
Post-translational protein phosphorylation	R-HSA-8957275	8.997678e-01	0.046	0	0
Pre-NOTCH Processing in Golgi	R-HSA-1912420	9.013647e-01	0.045	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	9.013647e-01	0.045	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	9.013647e-01	0.045	0	0
Diseases of hemostasis	R-HSA-9671793	9.013647e-01	0.045	0	0
Other interleukin signaling	R-HSA-449836	9.013647e-01	0.045	0	0
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.052864e-01	0.043	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	9.052864e-01	0.043	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	9.099408e-01	0.041	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	9.104461e-01	0.041	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	9.104461e-01	0.041	0	0
Formation of ATP by chemiosmotic coupling	R-HSA-163210	9.104461e-01	0.041	0	0
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.104461e-01	0.041	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	9.104461e-01	0.041	0	0
Creatine metabolism	R-HSA-71288	9.104461e-01	0.041	0	0
Acyl chain remodelling of PI	R-HSA-1482922	9.104461e-01	0.041	0	0
Common Pathway of Fibrin Clot Formation	R-HSA-140875	9.104461e-01	0.041	0	0
Eicosanoid ligand-binding receptors	R-HSA-391903	9.104461e-01	0.041	0	0
Chemokine receptors bind chemokines	R-HSA-380108	9.118322e-01	0.040	0	0
Acyl chain remodelling of PE	R-HSA-1482839	9.123364e-01	0.040	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	9.123364e-01	0.040	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	9.123364e-01	0.040	0	0
Metabolism of ingested SeMet, Sec, MeSec into H2Se	R-HSA-2408508	9.123364e-01	0.040	0	0
Class B/2 (Secretin family receptors)	R-HSA-373080	9.144093e-01	0.039	0	0
Integrin cell surface interactions	R-HSA-216083	9.165725e-01	0.038	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	9.186919e-01	0.037	0	0
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.186919e-01	0.037	0	0
Abacavir metabolism	R-HSA-2161541	9.186919e-01	0.037	0	0
Signalling to RAS	R-HSA-167044	9.186919e-01	0.037	0	0
Acyl chain remodelling of PG	R-HSA-1482925	9.186919e-01	0.037	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	9.188465e-01	0.037	0	0
HS-GAG biosynthesis	R-HSA-2022928	9.188918e-01	0.037	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	9.188918e-01	0.037	0	0
RNA Polymerase III Transcription	R-HSA-74158	9.188918e-01	0.037	0	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.188918e-01	0.037	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	9.188918e-01	0.037	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.191881e-01	0.037	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.216013e-01	0.035	0	0
Metabolism of proteins	R-HSA-392499	9.216065e-01	0.035	1	0
Voltage gated Potassium channels	R-HSA-1296072	9.249837e-01	0.034	0	0
Metabolism of folate and pterines	R-HSA-196757	9.249837e-01	0.034	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	9.261789e-01	0.033	0	0
Ribavirin ADME	R-HSA-9755088	9.261789e-01	0.033	0	0
Molybdenum cofactor biosynthesis	R-HSA-947581	9.261789e-01	0.033	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.269641e-01	0.033	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.269641e-01	0.033	0	0
Post-translational protein modification	R-HSA-597592	9.288969e-01	0.032	1	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	9.297789e-01	0.032	0	0
Elastic fibre formation	R-HSA-1566948	9.306419e-01	0.031	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	9.306419e-01	0.031	0	0
Nucleotide biosynthesis	R-HSA-8956320	9.329545e-01	0.030	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	9.329768e-01	0.030	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	9.329768e-01	0.030	0	0
Regulation of IFNA/IFNB signaling	R-HSA-912694	9.329768e-01	0.030	0	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	9.329768e-01	0.030	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	9.329768e-01	0.030	0	0
RAF-independent MAPK1/3 activation	R-HSA-112409	9.329768e-01	0.030	0	0
Neurotoxicity of clostridium toxins	R-HSA-168799	9.329768e-01	0.030	0	0
Signaling by KIT in disease	R-HSA-9669938	9.329768e-01	0.030	0	0
Fructose metabolism	R-HSA-5652084	9.329768e-01	0.030	0	0
Ethanol oxidation	R-HSA-71384	9.329768e-01	0.030	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	9.329768e-01	0.030	0	0
Cytoprotection by HMOX1	R-HSA-9707564	9.375147e-01	0.028	0	0
Interleukin receptor SHC signaling	R-HSA-912526	9.391491e-01	0.027	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	9.391491e-01	0.027	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	9.391491e-01	0.027	0	0
Formation of the ureteric bud	R-HSA-9830674	9.391491e-01	0.027	0	0
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	9.391491e-01	0.027	0	0
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	9.391491e-01	0.027	0	0
ABC transporters in lipid homeostasis	R-HSA-1369062	9.391491e-01	0.027	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	9.391491e-01	0.027	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	9.391491e-01	0.027	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	9.407686e-01	0.027	0	0
SLC transporter disorders	R-HSA-5619102	9.421346e-01	0.026	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	9.439332e-01	0.025	0	0
Potassium Channels	R-HSA-1296071	9.446375e-01	0.025	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	9.447534e-01	0.025	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	9.447534e-01	0.025	0	0
Complex III assembly	R-HSA-9865881	9.447534e-01	0.025	0	0
Mitochondrial RNA degradation	R-HSA-9836573	9.447534e-01	0.025	0	0
Interleukin-6 family signaling	R-HSA-6783589	9.447534e-01	0.025	0	0
Maturation of spike protein	R-HSA-9694548	9.452890e-01	0.024	0	0
Metabolism of amine-derived hormones	R-HSA-209776	9.456199e-01	0.024	0	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.491068e-01	0.023	0	0
Keratinization	R-HSA-6805567	9.492606e-01	0.023	0	0
Dectin-2 family	R-HSA-5621480	9.493216e-01	0.023	0	0
HIV Transcription Initiation	R-HSA-167161	9.494795e-01	0.023	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	9.494795e-01	0.023	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	9.494795e-01	0.023	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	9.498418e-01	0.022	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	9.498418e-01	0.022	0	0
Hyaluronan degradation	R-HSA-2160916	9.498418e-01	0.022	0	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	9.498418e-01	0.022	0	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.498418e-01	0.022	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.507297e-01	0.022	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	9.544618e-01	0.020	0	0
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	9.544618e-01	0.020	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.544618e-01	0.020	0	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	9.544618e-01	0.020	0	0
Urea cycle	R-HSA-70635	9.544618e-01	0.020	0	0
Sphingolipid catabolism	R-HSA-9845614	9.544618e-01	0.020	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	9.544618e-01	0.020	0	0
Extension of Telomeres	R-HSA-180786	9.560304e-01	0.020	0	0
Regulation of beta-cell development	R-HSA-186712	9.560304e-01	0.020	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	9.560304e-01	0.020	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	9.569592e-01	0.019	0	0
Signaling by BMP	R-HSA-201451	9.586565e-01	0.018	0	0
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.586565e-01	0.018	0	0
Synthesis of PE	R-HSA-1483213	9.586565e-01	0.018	0	0
GABA receptor activation	R-HSA-977443	9.590641e-01	0.018	0	0
Metabolism of polyamines	R-HSA-351202	9.590641e-01	0.018	0	0
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.602892e-01	0.018	0	0
PI Metabolism	R-HSA-1483255	9.606170e-01	0.017	0	0
Telomere Extension By Telomerase	R-HSA-171319	9.624651e-01	0.017	0	0
Prednisone ADME	R-HSA-9757110	9.624651e-01	0.017	0	0
Pyrimidine salvage	R-HSA-73614	9.624651e-01	0.017	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.633713e-01	0.016	0	0
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.633713e-01	0.016	0	0
Mitochondrial protein import	R-HSA-1268020	9.645511e-01	0.016	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	9.645511e-01	0.016	0	0
Signaling by PDGF	R-HSA-186797	9.645511e-01	0.016	0	0
Parasite infection	R-HSA-9664407	9.658454e-01	0.015	0	0
Leishmania phagocytosis	R-HSA-9664417	9.658454e-01	0.015	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.658454e-01	0.015	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.659230e-01	0.015	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	9.690625e-01	0.014	0	0
DAP12 signaling	R-HSA-2424491	9.690625e-01	0.014	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.690625e-01	0.014	0	0
Neurotransmitter clearance	R-HSA-112311	9.690625e-01	0.014	0	0
Extracellular matrix organization	R-HSA-1474244	9.694494e-01	0.013	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.698369e-01	0.013	0	0
Collagen formation	R-HSA-1474290	9.716697e-01	0.012	0	0
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	9.719130e-01	0.012	0	0
Kidney development	R-HSA-9830369	9.753899e-01	0.011	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	9.753899e-01	0.011	0	0
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.768506e-01	0.010	0	0
Recycling of bile acids and salts	R-HSA-159418	9.768506e-01	0.010	0	0
Miscellaneous transport and binding events	R-HSA-5223345	9.789839e-01	0.009	0	0
Heme degradation	R-HSA-189483	9.789839e-01	0.009	0	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.809207e-01	0.008	0	0
Hyaluronan metabolism	R-HSA-2142845	9.809207e-01	0.008	0	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.817103e-01	0.008	0	0
ECM proteoglycans	R-HSA-3000178	9.817103e-01	0.008	0	0
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.826791e-01	0.008	0	0
Paracetamol ADME	R-HSA-9753281	9.838799e-01	0.007	0	0
GPVI-mediated activation cascade	R-HSA-114604	9.842755e-01	0.007	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.848993e-01	0.007	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.853987e-01	0.006	0	0
NCAM1 interactions	R-HSA-419037	9.857249e-01	0.006	0	0
Lysine catabolism	R-HSA-71064	9.857249e-01	0.006	0	0
Collagen chain trimerization	R-HSA-8948216	9.857249e-01	0.006	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.868632e-01	0.006	0	0
tRNA processing in the mitochondrion	R-HSA-6785470	9.870408e-01	0.006	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	9.870408e-01	0.006	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.874486e-01	0.005	0	0
Heparan sulfate/heparin (HS-GAG) metabolism	R-HSA-1638091	9.884572e-01	0.005	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	9.892211e-01	0.005	0	0
rRNA processing in the mitochondrion	R-HSA-8868766	9.893200e-01	0.005	0	0
Interleukin-2 family signaling	R-HSA-451927	9.893200e-01	0.005	0	0
RAB geranylgeranylation	R-HSA-8873719	9.893866e-01	0.005	0	0
Intra-Golgi traffic	R-HSA-6811438	9.911986e-01	0.004	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	9.920102e-01	0.003	0	0
CD22 mediated BCR regulation	R-HSA-5690714	9.924262e-01	0.003	0	0
Pyrimidine catabolism	R-HSA-73621	9.927469e-01	0.003	0	0
DAP12 interactions	R-HSA-2172127	9.934158e-01	0.003	0	0
Surfactant metabolism	R-HSA-5683826	9.934158e-01	0.003	0	0
Methylation	R-HSA-156581	9.934158e-01	0.003	0	0
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.934158e-01	0.003	0	0
PPARA activates gene expression	R-HSA-1989781	9.936078e-01	0.003	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.936080e-01	0.003	0	0
Degradation of cysteine and homocysteine	R-HSA-1614558	9.940230e-01	0.003	0	0
Nicotinate metabolism	R-HSA-196807	9.941291e-01	0.003	0	0
Metabolism of steroid hormones	R-HSA-196071	9.941291e-01	0.003	0	0
O-linked glycosylation of mucins	R-HSA-913709	9.946086e-01	0.002	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.946086e-01	0.002	0	0
Synthesis of PC	R-HSA-1483191	9.950747e-01	0.002	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	9.955290e-01	0.002	0	0
Plasma lipoprotein remodeling	R-HSA-8963899	9.955290e-01	0.002	0	0
Retinoid metabolism and transport	R-HSA-975634	9.958279e-01	0.002	0	0
Metabolism of cofactors	R-HSA-8978934	9.958279e-01	0.002	0	0
Visual phototransduction	R-HSA-2187338	9.958985e-01	0.002	0	0
Neurotransmitter release cycle	R-HSA-112310	9.960697e-01	0.002	0	0
Azathioprine ADME	R-HSA-9748787	9.963158e-01	0.002	0	0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.963158e-01	0.002	0	0
G alpha (q) signalling events	R-HSA-416476	9.964667e-01	0.002	0	0
Branched-chain amino acid catabolism	R-HSA-70895	9.966557e-01	0.001	0	0
Complex IV assembly	R-HSA-9864848	9.966557e-01	0.001	0	0
Cytosolic sulfonation of small molecules	R-HSA-156584	9.966557e-01	0.001	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.975103e-01	0.001	0	0
Asparagine N-linked glycosylation	R-HSA-446203	9.978703e-01	0.001	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.979059e-01	0.001	0	0
Digestion	R-HSA-8935690	9.979390e-01	0.001	0	0
Synthesis of PA	R-HSA-1483166	9.981292e-01	0.001	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	9.981470e-01	0.001	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.982394e-01	0.001	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.984198e-01	0.001	0	0
Sialic acid metabolism	R-HSA-4085001	9.984586e-01	0.001	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.985763e-01	0.001	0	0
tRNA Aminoacylation	R-HSA-379724	9.986009e-01	0.001	0	0
Nucleotide salvage	R-HSA-8956321	9.987300e-01	0.001	0	0
Collagen degradation	R-HSA-1442490	9.987300e-01	0.001	0	0
Complex I biogenesis	R-HSA-6799198	9.989537e-01	0.000	0	0
Digestion and absorption	R-HSA-8963743	9.989537e-01	0.000	0	0
Sulfur amino acid metabolism	R-HSA-1614635	9.989564e-01	0.000	0	0
GPCR downstream signalling	R-HSA-388396	9.990599e-01	0.000	0	0
Latent infection - Other responses of Mtb to phagocytosis	R-HSA-1222499	9.991380e-01	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	9.992207e-01	0.000	0	0
Antimicrobial peptides	R-HSA-6803157	9.994317e-01	0.000	0	0
COPII-mediated vesicle transport	R-HSA-204005	9.994690e-01	0.000	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.994690e-01	0.000	0	0
FCERI mediated MAPK activation	R-HSA-2871796	9.994766e-01	0.000	0	0
FCGR activation	R-HSA-2029481	9.994831e-01	0.000	0	0
Metabolism of porphyrins	R-HSA-189445	9.995180e-01	0.000	0	0
Purine catabolism	R-HSA-74259	9.995626e-01	0.000	0	0
Aspirin ADME	R-HSA-9749641	9.996030e-01	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.996332e-01	0.000	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.996370e-01	0.000	0	0
Citric acid cycle (TCA cycle)	R-HSA-71403	9.996729e-01	0.000	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	9.997654e-01	0.000	0	0
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.997781e-01	0.000	0	0
G alpha (i) signalling events	R-HSA-418594	9.998393e-01	0.000	0	0
Peroxisomal lipid metabolism	R-HSA-390918	9.998633e-01	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.998844e-01	0.000	0	0
Signaling by GPCR	R-HSA-372790	9.998954e-01	0.000	0	0
Bile acid and bile salt metabolism	R-HSA-194068	9.999045e-01	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	9.999075e-01	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	9.999146e-01	0.000	0	0
Sensory perception of taste	R-HSA-9717189	9.999232e-01	0.000	0	0
Arachidonate metabolism	R-HSA-2142753	9.999367e-01	0.000	0	0
Transport of small molecules	R-HSA-382551	9.999738e-01	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	9.999742e-01	0.000	0	0
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999753e-01	0.000	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.999762e-01	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	9.999812e-01	0.000	0	0
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999867e-01	0.000	0	0
Nucleotide catabolism	R-HSA-8956319	9.999869e-01	0.000	0	0
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999900e-01	0.000	0	0
O-linked glycosylation	R-HSA-5173105	9.999947e-01	0.000	0	0
Phospholipid metabolism	R-HSA-1483257	9.999953e-01	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	9.999959e-01	0.000	0	0
Metabolism of steroids	R-HSA-8957322	9.999980e-01	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	9.999980e-01	0.000	0	0
Regulation of Complement cascade	R-HSA-977606	9.999986e-01	0.000	0	0
Drug ADME	R-HSA-9748784	9.999987e-01	0.000	0	0
Respiratory electron transport	R-HSA-611105	9.999990e-01	0.000	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999992e-01	0.000	0	0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.999992e-01	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999995e-01	0.000	0	0
Complement cascade	R-HSA-166658	9.999999e-01	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	9.999999e-01	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999999e-01	0.000	0	0
Diseases of metabolism	R-HSA-5668914	9.999999e-01	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000	0	0
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000	0	0
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000	0	0
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000	0	0
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000	0	0
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000	0	0
Interaction between PHLDA1 and AURKA	R-HSA-8854521	1.000000e+00	0.000	1	1