CHAK1

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
O00418 S78 GPS6|EPSD|PSP EEF2K KYysNLtKsERysssGsPANsFHFKEAWKHAIQKAKHMPDP
P04083 S5 GPS6|SIGNOR|iPTMNet|EPSD|PSP ANXA1 ANX1 LPC1 ________________MAMVsEFLKQAWFIENEEQEyVQtV
P16885 S1164 PSP PLCG2 DPNFLAHATYPIKAVKSGFRsVPLKNGYSEDIELASLLVFC
P16885 T1045 PSP PLCG2 HALFSLNGRTGYVLQPESMRtEKYDPMPPESQRKILMTLTV
P28289 S2 EPSD|PSP TMOD1 D9S57E TMOD ___________________MsYRRELEKyRDLDEDEILGAL
P28289 T54 EPSD|PSP TMOD1 D9S57E TMOD LDELDPDNALLPAGLRQKDQtTKAPTGPFKREELLDHLEKQ
P35579 S1803 GPS6|ELM|EPSD|PSP MYH9 LERQNKELKVKLQEMEGtVKsKYKAsITALEAKIAQLEEQL
P35579 S1808 GPS6|ELM|EPSD|PSP MYH9 KELKVKLQEMEGtVKsKYKAsITALEAKIAQLEEQLDNEtK
P35579 T1800 GPS6|ELM|EPSD|PSP MYH9 RQQLERQNKELKVKLQEMEGtVKsKYKAsITALEAKIAQLE
Q96QT4 S1191 EPSD|PSP TRPM7 CHAK1 LTRPC7 HDFEEQCVEMYFNEKDDKFHsGsEERIRVTFERVEQMCIQI
Q96QT4 S1193 EPSD|PSP TRPM7 CHAK1 LTRPC7 FEEQCVEMYFNEKDDKFHsGsEERIRVTFERVEQMCIQIKE
Q96QT4 S1255 EPSD|PSP TRPM7 CHAK1 LTRPC7 LQDLSALTVDTLKTLTAQKAsEAsKVHNEItRELsIsKHLA
Q96QT4 S1258 EPSD|PSP TRPM7 CHAK1 LTRPC7 LSALTVDTLKTLTAQKAsEAsKVHNEItRELsIsKHLAQNL
Q96QT4 S1271 EPSD|PSP TRPM7 CHAK1 LTRPC7 AQKAsEAsKVHNEItRELsIsKHLAQNLIDDGPVRPsVWKK
Q96QT4 S1287 EPSD|PSP TRPM7 CHAK1 LTRPC7 ELsIsKHLAQNLIDDGPVRPsVWKKHGVVNTLSssLPQGDL
Q96QT4 S1358 EPSD|PSP TRPM7 CHAK1 LTRPC7 PQRKEFNFPEAGsssGALFPsAVsPPELRQRLHGVELLKIF
Q96QT4 S1387 EPSD|PSP TRPM7 CHAK1 LTRPC7 QRLHGVELLKIFNKNQKLGssstsIPHLssPPTKFFVstPs
Q96QT4 S1390 EPSD|PSP TRPM7 CHAK1 LTRPC7 HGVELLKIFNKNQKLGssstsIPHLssPPTKFFVstPsQPS
Q96QT4 S1404 EPSD|PSP TRPM7 CHAK1 LTRPC7 LGssstsIPHLssPPTKFFVstPsQPSCKSHLETGTKDQET
Q96QT4 S1407 EPSD|PSP TRPM7 CHAK1 LTRPC7 sstsIPHLssPPTKFFVstPsQPSCKSHLETGTKDQETVCS
Q96QT4 S1446 EPSD|PSP TRPM7 CHAK1 LTRPC7 CSKATEGDNtEFGAFVGHRDsMDLQRFKEtsNKIKILsNNN
Q96QT4 S1456 EPSD|PSP TRPM7 CHAK1 LTRPC7 EFGAFVGHRDsMDLQRFKEtsNKIKILsNNNtsENtLKRVs
Q96QT4 S1463 EPSD|PSP TRPM7 CHAK1 LTRPC7 HRDsMDLQRFKEtsNKIKILsNNNtsENtLKRVssLAGFtD
Q96QT4 S1468 EPSD|PSP TRPM7 CHAK1 LTRPC7 DLQRFKEtsNKIKILsNNNtsENtLKRVssLAGFtDCHRts
Q96QT4 S1476 EPSD|PSP TRPM7 CHAK1 LTRPC7 sNKIKILsNNNtsENtLKRVssLAGFtDCHRtsIPVHsKQA
Q96QT4 S1477 EPSD|PSP TRPM7 CHAK1 LTRPC7 NKIKILsNNNtsENtLKRVssLAGFtDCHRtsIPVHsKQAE
Q96QT4 S1493 EPSD|PSP TRPM7 CHAK1 LTRPC7 KRVssLAGFtDCHRtsIPVHsKQAEKIsRRPstEDtHEVDs
Q96QT4 S1513 EPSD|PSP TRPM7 CHAK1 LTRPC7 sKQAEKIsRRPstEDtHEVDsKAALIPDWLQDRPsNREMPs
Q96QT4 S1527 EPSD|PSP TRPM7 CHAK1 LTRPC7 DtHEVDsKAALIPDWLQDRPsNREMPsEEGtLNGLtsPFKP
Q96QT4 S1533 EPSD|PSP TRPM7 CHAK1 LTRPC7 sKAALIPDWLQDRPsNREMPsEEGtLNGLtsPFKPAMDtNY
Q96QT4 S1543 EPSD|PSP TRPM7 CHAK1 LTRPC7 QDRPsNREMPsEEGtLNGLtsPFKPAMDtNYYYSAVERNNL
Q96QT4 S1567 EPSD|PSP TRPM7 CHAK1 LTRPC7 PAMDtNYYYSAVERNNLMRLsQsIPFTPVPPRGEPVtVYRL
Q96QT4 S1569 EPSD|PSP TRPM7 CHAK1 LTRPC7 MDtNYYYSAVERNNLMRLsQsIPFTPVPPRGEPVtVYRLEE
Q96QT4 S1598 EPSD|PSP TRPM7 CHAK1 LTRPC7 RGEPVtVYRLEESSPNILNNsMSSWSQLGLCAKIEFLsKEE
Q96QT4 S1615 EPSD|PSP TRPM7 CHAK1 LTRPC7 LNNsMSSWSQLGLCAKIEFLsKEEMGGGLRRAVKVQCTWSE
Q96QT4 S1660 EPSD|PSP TRPM7 CHAK1 LTRPC7 KSGHLYIIKSFLPEVVNTWSsIYKEDTVLHLCLREIQQQRA
Q96QT4 S1695 EPSD|PSP TRPM7 CHAK1 LTRPC7 IQQQRAAQKLtFAFNQMKPKsIPYSPRFLEVFLLYCHSAGQ
Q96QT4 S1779 EPSD|PSP TRPM7 CHAK1 LTRPC7 TRGELLVLDLQGVGENLTDPsVIKAEEKRSCDMVFGPANLG
Q96QT4 S1851 EPSD|PSP TRPM7 CHAK1 LTRPC7 PDKIIFPQDEPSDLNLQPGNstKEsEstNsVRLML______
Q96QT4 S1860 EPSD|PSP TRPM7 CHAK1 LTRPC7 EPSDLNLQPGNstKEsEstNsVRLML_______________
Q96QT4 T1163 EPSD|PSP TRPM7 CHAK1 LTRPC7 CCICKRRKKDKTSDGPKLFLtEEDQKKLHDFEEQCVEMYFN
Q96QT4 T1265 EPSD|PSP TRPM7 CHAK1 LTRPC7 TLKTLTAQKAsEAsKVHNEItRELsIsKHLAQNLIDDGPVR
Q96QT4 T1405 EPSD|PSP TRPM7 CHAK1 LTRPC7 GssstsIPHLssPPTKFFVstPsQPSCKSHLETGTKDQETV
Q96QT4 T1435 EPSD|PSP TRPM7 CHAK1 LTRPC7 LETGTKDQETVCSKATEGDNtEFGAFVGHRDsMDLQRFKEt
Q96QT4 T1455 EPSD|PSP TRPM7 CHAK1 LTRPC7 tEFGAFVGHRDsMDLQRFKEtsNKIKILsNNNtsENtLKRV
Q96QT4 T1471 EPSD|PSP TRPM7 CHAK1 LTRPC7 RFKEtsNKIKILsNNNtsENtLKRVssLAGFtDCHRtsIPV
Q96QT4 T1482 EPSD|PSP TRPM7 CHAK1 LTRPC7 LsNNNtsENtLKRVssLAGFtDCHRtsIPVHsKQAEKIsRR
Q96QT4 T1505 EPSD|PSP TRPM7 CHAK1 LTRPC7 HRtsIPVHsKQAEKIsRRPstEDtHEVDsKAALIPDWLQDR
Q96QT4 T1508 EPSD|PSP TRPM7 CHAK1 LTRPC7 sIPVHsKQAEKIsRRPstEDtHEVDsKAALIPDWLQDRPsN
Q96QT4 T1537 EPSD|PSP TRPM7 CHAK1 LTRPC7 LIPDWLQDRPsNREMPsEEGtLNGLtsPFKPAMDtNYYYSA
Q96QT4 T1542 EPSD|PSP TRPM7 CHAK1 LTRPC7 LQDRPsNREMPsEEGtLNGLtsPFKPAMDtNYYYSAVERNN
Q96QT4 T1551 EPSD|PSP TRPM7 CHAK1 LTRPC7 MPsEEGtLNGLtsPFKPAMDtNYYYSAVERNNLMRLsQsIP
Q96QT4 T1583 EPSD|PSP TRPM7 CHAK1 LTRPC7 LMRLsQsIPFTPVPPRGEPVtVYRLEESSPNILNNsMSSWS
Q96QT4 T1685 EPSD|PSP TRPM7 CHAK1 LTRPC7 DTVLHLCLREIQQQRAAQKLtFAFNQMKPKsIPYSPRFLEV
Q96QT4 T1830 EPSD|PSP TRPM7 CHAK1 LTRPC7 HHCNSCCRKLKLPDLKRNDYtPDKIIFPQDEPSDLNLQPGN
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 6.106519e-10 9.214 0 0
Apoptotic execution phase R-HSA-75153 5.417506e-09 8.266 0 0
Signal Transduction R-HSA-162582 7.125179e-09 8.147 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 7.713659e-09 8.113 0 0
Cell Cycle, Mitotic R-HSA-69278 6.607068e-08 7.180 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 7.087176e-08 7.150 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.710165e-07 6.767 0 0
Cell Cycle Checkpoints R-HSA-69620 4.912150e-07 6.309 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.469938e-06 5.833 0 0
Signaling by VEGF R-HSA-194138 1.567650e-06 5.805 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 5.149430e-06 5.288 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 6.774719e-06 5.169 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 9.327339e-06 5.030 0 0
Amplification of signal from the kinetochores R-HSA-141424 9.327339e-06 5.030 0 0
Axon guidance R-HSA-422475 1.081844e-05 4.966 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.268224e-05 4.897 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.468292e-05 4.833 0 0
Regulation of TP53 Activity R-HSA-5633007 2.026101e-05 4.693 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.208340e-05 4.656 0 0
Nervous system development R-HSA-9675108 2.395295e-05 4.621 0 0
Post NMDA receptor activation events R-HSA-438064 3.335917e-05 4.477 0 0
Mitotic Prometaphase R-HSA-68877 4.272764e-05 4.369 0 0
Mitotic Anaphase R-HSA-68882 4.128179e-05 4.384 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 4.645143e-05 4.333 0 0
Muscle contraction R-HSA-397014 4.586557e-05 4.339 0 0
mRNA Splicing - Major Pathway R-HSA-72163 4.840326e-05 4.315 0 0
Metabolism of RNA R-HSA-8953854 5.105108e-05 4.292 0 0
Signaling by RAS mutants R-HSA-6802949 6.304757e-05 4.200 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 6.304757e-05 4.200 0 0
Signaling downstream of RAS mutants R-HSA-9649948 6.304757e-05 4.200 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 6.304757e-05 4.200 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 8.950130e-05 4.048 0 0
Signaling by ALK in cancer R-HSA-9700206 8.950130e-05 4.048 0 0
mRNA Splicing R-HSA-72172 1.006422e-04 3.997 0 0
Signaling by ERBB2 R-HSA-1227986 1.034938e-04 3.985 0 0
Gene expression (Transcription) R-HSA-74160 1.313084e-04 3.882 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.402077e-04 3.853 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.462712e-04 3.835 0 0
Apoptosis R-HSA-109581 1.790217e-04 3.747 0 0
Programmed Cell Death R-HSA-5357801 1.966060e-04 3.706 0 0
Signaling by Hippo R-HSA-2028269 2.294709e-04 3.639 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 2.513863e-04 3.600 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.659640e-04 3.575 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.765997e-04 3.558 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.955553e-04 3.529 0 0
Signaling by RAF1 mutants R-HSA-9656223 3.504755e-04 3.455 0 0
RNA Polymerase II Transcription R-HSA-73857 3.801092e-04 3.420 0 0
MAPK family signaling cascades R-HSA-5683057 4.083233e-04 3.389 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 4.263511e-04 3.370 0 0
Intracellular signaling by second messengers R-HSA-9006925 4.185186e-04 3.378 0 0
M Phase R-HSA-68886 5.535563e-04 3.257 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 5.850445e-04 3.233 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 6.119859e-04 3.213 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 6.172432e-04 3.210 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 6.415057e-04 3.193 0 0
ESR-mediated signaling R-HSA-8939211 6.435314e-04 3.191 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 6.954992e-04 3.158 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 7.200802e-04 3.143 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 7.130752e-04 3.147 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 7.060794e-04 3.151 0 0
MAP2K and MAPK activation R-HSA-5674135 9.052713e-04 3.043 0 0
Oncogenic MAPK signaling R-HSA-6802957 9.618891e-04 3.017 0 0
Cell-extracellular matrix interactions R-HSA-446353 9.647790e-04 3.016 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.083244e-03 2.965 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.046370e-03 2.980 0 0
Semaphorin interactions R-HSA-373755 1.040534e-03 2.983 0 0
Separation of Sister Chromatids R-HSA-2467813 1.239073e-03 2.907 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.348233e-03 2.870 0 0
Generic Transcription Pathway R-HSA-212436 1.432837e-03 2.844 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.489345e-03 2.827 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.503983e-03 2.823 0 0
Cellular responses to stimuli R-HSA-8953897 1.520681e-03 2.818 0 0
Co-stimulation by CD28 R-HSA-389356 1.632352e-03 2.787 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.632479e-03 2.787 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.725984e-03 2.763 0 0
Cellular response to heat stress R-HSA-3371556 1.672267e-03 2.777 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.728149e-03 2.762 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.803388e-03 2.744 0 0
Striated Muscle Contraction R-HSA-390522 1.910607e-03 2.719 0 0
EPH-Ephrin signaling R-HSA-2682334 1.827669e-03 2.738 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.836834e-03 2.736 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.913902e-03 2.718 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.913902e-03 2.718 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.921009e-03 2.716 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.921009e-03 2.716 0 0
Interleukin-37 signaling R-HSA-9008059 1.921009e-03 2.716 0 0
G-protein mediated events R-HSA-112040 2.066905e-03 2.685 0 0
Cellular responses to stress R-HSA-2262752 2.091890e-03 2.679 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.388997e-03 2.622 0 0
Nuclear import of Rev protein R-HSA-180746 2.404876e-03 2.619 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.784342e-03 2.422 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.784342e-03 2.422 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.784342e-03 2.422 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.784342e-03 2.422 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.784342e-03 2.422 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.784342e-03 2.422 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.784342e-03 2.422 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.784342e-03 2.422 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.784342e-03 2.422 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.784342e-03 2.422 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.784342e-03 2.422 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.084908e-03 2.511 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 3.084908e-03 2.511 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.773826e-03 2.557 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.773826e-03 2.557 0 0
p38MAPK events R-HSA-171007 3.390555e-03 2.470 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.777218e-03 2.423 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 3.977094e-03 2.400 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.977094e-03 2.400 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.125447e-03 2.505 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.991552e-03 2.399 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.991552e-03 2.399 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 3.613872e-03 2.442 0 0
MAP kinase activation R-HSA-450294 3.417942e-03 2.466 0 0
Ion homeostasis R-HSA-5578775 3.159258e-03 2.500 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.586413e-03 2.587 0 0
Signalling to ERKs R-HSA-187687 3.000575e-03 2.523 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 3.876034e-03 2.412 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.876034e-03 2.412 0 0
Platelet activation, signaling and aggregation R-HSA-76002 2.486051e-03 2.604 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.125447e-03 2.505 0 0
NRAGE signals death through JNK R-HSA-193648 3.159258e-03 2.500 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 4.022930e-03 2.395 0 0
Cell-Cell communication R-HSA-1500931 3.364018e-03 2.473 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.903267e-03 2.537 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.119789e-03 2.506 0 0
Sema4D in semaphorin signaling R-HSA-400685 4.035558e-03 2.394 0 0
Long-term potentiation R-HSA-9620244 4.035558e-03 2.394 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 4.068367e-03 2.391 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 4.068367e-03 2.391 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 4.068367e-03 2.391 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 4.068367e-03 2.391 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 4.068367e-03 2.391 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 4.068367e-03 2.391 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.167716e-03 2.380 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 4.652677e-03 2.332 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 4.652677e-03 2.332 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 4.555901e-03 2.341 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 4.555901e-03 2.341 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 4.555901e-03 2.341 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 4.451556e-03 2.351 0 0
Signaling by PTK6 R-HSA-8848021 4.684603e-03 2.329 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.684603e-03 2.329 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 4.806934e-03 2.318 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 5.012367e-03 2.300 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 5.111151e-03 2.291 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 5.199344e-03 2.284 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 5.226847e-03 2.282 0 0
DNA Double-Strand Break Repair R-HSA-5693532 5.287209e-03 2.277 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 5.910504e-03 2.228 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 5.910504e-03 2.228 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 5.910504e-03 2.228 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.372956e-03 2.270 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 5.820100e-03 2.235 0 0
RAF activation R-HSA-5673000 5.910504e-03 2.228 0 0
Cytokine Signaling in Immune system R-HSA-1280215 5.827421e-03 2.235 0 0
Diseases of DNA repair R-HSA-9675135 5.731040e-03 2.242 0 0
Cellular Senescence R-HSA-2559583 6.240944e-03 2.205 0 0
Signaling by Interleukins R-HSA-449147 6.375127e-03 2.196 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 6.391433e-03 2.194 0 0
MyD88-independent TLR4 cascade R-HSA-166166 6.501651e-03 2.187 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 6.501651e-03 2.187 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 6.629051e-03 2.179 0 0
Co-inhibition by CTLA4 R-HSA-389513 6.629051e-03 2.179 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 6.715027e-03 2.173 0 0
Signaling by APC mutants R-HSA-4839744 6.981888e-03 2.156 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 6.981888e-03 2.156 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 6.981888e-03 2.156 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 6.981888e-03 2.156 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 7.150086e-03 2.146 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 7.150086e-03 2.146 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 7.208440e-03 2.142 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 8.065515e-03 2.093 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 7.293664e-03 2.137 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 7.208440e-03 2.142 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 7.999636e-03 2.097 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 8.065515e-03 2.093 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 8.065515e-03 2.093 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.206496e-03 2.142 0 0
Interleukin-12 signaling R-HSA-9020591 7.736683e-03 2.111 0 0
Signalling to RAS R-HSA-167044 8.571093e-03 2.067 0 0
Regulation of TP53 Degradation R-HSA-6804757 8.723489e-03 2.059 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 8.873686e-03 2.052 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 8.873686e-03 2.052 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 8.956217e-03 2.048 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 9.028726e-03 2.044 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 9.376067e-03 2.028 0 0
Integrin signaling R-HSA-354192 9.376067e-03 2.028 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 9.376067e-03 2.028 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 9.615466e-03 2.017 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 9.675955e-03 2.014 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 9.675955e-03 2.014 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 1.080683e-02 1.966 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.080683e-02 1.966 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.092220e-02 1.962 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.020926e-02 1.991 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.107536e-02 1.956 0 0
Ephrin signaling R-HSA-3928664 1.106409e-02 1.956 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.037526e-02 1.984 0 0
Autophagy R-HSA-9612973 1.102637e-02 1.958 0 0
Activation of RAC1 R-HSA-428540 9.931705e-03 2.003 0 0
Signaling by AXIN mutants R-HSA-4839735 9.931705e-03 2.003 0 0
Signaling by AMER1 mutants R-HSA-4839748 9.931705e-03 2.003 0 0
Signaling by ROBO receptors R-HSA-376176 1.087181e-02 1.964 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.123356e-02 1.949 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.130053e-02 1.947 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.143241e-02 1.942 0 0
Peptide chain elongation R-HSA-156902 1.143499e-02 1.942 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.194460e-02 1.923 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.222136e-02 1.913 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.245533e-02 1.905 0 0
Interleukin-17 signaling R-HSA-448424 1.249929e-02 1.903 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.250013e-02 1.903 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.250013e-02 1.903 0 0
Myogenesis R-HSA-525793 1.303684e-02 1.885 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.330829e-02 1.876 0 0
Influenza Infection R-HSA-168255 1.362904e-02 1.866 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.369377e-02 1.863 0 0
Signaling by NTRKs R-HSA-166520 1.372962e-02 1.862 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.411667e-02 1.850 0 0
Recycling pathway of L1 R-HSA-437239 1.421413e-02 1.847 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.427630e-02 1.845 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 1.505212e-02 1.822 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 1.505212e-02 1.822 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.505212e-02 1.822 0 0
Signal attenuation R-HSA-74749 1.718694e-02 1.765 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.596950e-02 1.797 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.481112e-02 1.829 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.481112e-02 1.829 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.481081e-02 1.829 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.650057e-02 1.783 0 0
mRNA 3'-end processing R-HSA-72187 1.482238e-02 1.829 0 0
FOXO-mediated transcription R-HSA-9614085 1.565250e-02 1.805 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.565250e-02 1.805 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.725629e-02 1.763 0 0
Macroautophagy R-HSA-1632852 1.710620e-02 1.767 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.522106e-02 1.818 0 0
Cardiac conduction R-HSA-5576891 1.653109e-02 1.782 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.718694e-02 1.765 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.481081e-02 1.829 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.575535e-02 1.803 0 0
DNA Repair R-HSA-73894 1.761091e-02 1.754 0 0
G0 and Early G1 R-HSA-1538133 1.779714e-02 1.750 0 0
Interleukin-12 family signaling R-HSA-447115 1.791886e-02 1.747 0 0
G alpha (12/13) signalling events R-HSA-416482 1.808519e-02 1.743 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.839410e-02 1.735 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.847671e-02 1.733 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 1.849244e-02 1.733 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.849244e-02 1.733 0 0
Pyroptosis R-HSA-5620971 1.937022e-02 1.713 0 0
Translation initiation complex formation R-HSA-72649 1.958030e-02 1.708 0 0
snRNP Assembly R-HSA-191859 1.994273e-02 1.700 0 0
Metabolism of non-coding RNA R-HSA-194441 1.994273e-02 1.700 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.030818e-02 1.692 0 0
FLT3 Signaling R-HSA-9607240 2.040174e-02 1.690 0 0
Cell junction organization R-HSA-446728 2.064095e-02 1.685 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 2.111749e-02 1.675 0 0
SOS-mediated signalling R-HSA-112412 2.111749e-02 1.675 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.121322e-02 1.673 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.121322e-02 1.673 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.121322e-02 1.673 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.121322e-02 1.673 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.146944e-02 1.668 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.264603e-02 1.645 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.327871e-02 1.633 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.337020e-02 1.631 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.340819e-02 1.631 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.353133e-02 1.628 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.353133e-02 1.628 0 0
Interleukin-2 signaling R-HSA-9020558 2.361374e-02 1.627 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.371631e-02 1.625 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.371631e-02 1.625 0 0
L1CAM interactions R-HSA-373760 2.371631e-02 1.625 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.752264e-02 1.560 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.752264e-02 1.560 0 0
DAP12 signaling R-HSA-2424491 2.773319e-02 1.557 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 2.706968e-02 1.568 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.656440e-02 1.576 0 0
Homology Directed Repair R-HSA-5693538 2.816656e-02 1.550 0 0
MTOR signalling R-HSA-165159 2.745047e-02 1.561 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.878732e-02 1.541 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 2.606475e-02 1.584 0 0
PLC beta mediated events R-HSA-112043 2.561123e-02 1.592 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.474487e-02 1.607 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 2.517277e-02 1.599 0 0
Deubiquitination R-HSA-5688426 2.781140e-02 1.556 0 0
Glycolysis R-HSA-70171 2.857227e-02 1.544 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.509238e-02 1.600 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 2.857414e-02 1.544 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.542866e-02 1.595 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.880410e-02 1.541 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.921678e-02 1.534 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.945153e-02 1.531 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.946306e-02 1.531 0 0
Polo-like kinase mediated events R-HSA-156711 2.946306e-02 1.531 0 0
Platelet sensitization by LDL R-HSA-432142 2.946306e-02 1.531 0 0
Signal amplification R-HSA-392518 2.946643e-02 1.531 0 0
NOD1/2 Signaling Pathway R-HSA-168638 2.946643e-02 1.531 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.006020e-02 1.522 0 0
Formation of annular gap junctions R-HSA-196025 3.006020e-02 1.522 0 0
Activation of RAS in B cells R-HSA-1169092 3.006020e-02 1.522 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 3.054140e-02 1.515 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.071889e-02 1.513 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 3.095306e-02 1.509 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 3.095306e-02 1.509 0 0
ERKs are inactivated R-HSA-202670 3.147920e-02 1.502 0 0
Signaling by SCF-KIT R-HSA-1433557 3.158137e-02 1.501 0 0
Toll-like Receptor Cascades R-HSA-168898 3.178220e-02 1.498 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 3.186921e-02 1.497 0 0
SARS-CoV-2 Infection R-HSA-9694516 3.212561e-02 1.493 0 0
Regulated Necrosis R-HSA-5218859 3.219835e-02 1.492 0 0
Smooth Muscle Contraction R-HSA-445355 3.241872e-02 1.489 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.250229e-02 1.488 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 3.928875e-02 1.406 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.928875e-02 1.406 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.928875e-02 1.406 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 3.928875e-02 1.406 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.928875e-02 1.406 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 3.928875e-02 1.406 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 3.928875e-02 1.406 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.928875e-02 1.406 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.928875e-02 1.406 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.748727e-02 1.426 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 3.748727e-02 1.426 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 3.748727e-02 1.426 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 4.087918e-02 1.388 0 0
Notch-HLH transcription pathway R-HSA-350054 3.345523e-02 1.476 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 3.842198e-02 1.415 0 0
RET signaling R-HSA-8853659 3.981765e-02 1.400 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 3.545698e-02 1.450 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 3.545698e-02 1.450 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.590097e-02 1.445 0 0
GPVI-mediated activation cascade R-HSA-114604 3.981765e-02 1.400 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.614675e-02 1.442 0 0
Netrin-1 signaling R-HSA-373752 3.614675e-02 1.442 0 0
G2/M Checkpoints R-HSA-69481 4.071644e-02 1.390 0 0
Selective autophagy R-HSA-9663891 3.353105e-02 1.475 0 0
Mitochondrial biogenesis R-HSA-1592230 4.024335e-02 1.395 0 0
Response of endothelial cells to shear stress R-HSA-9860931 4.067802e-02 1.391 0 0
RUNX2 regulates bone development R-HSA-8941326 3.981765e-02 1.400 0 0
Neuronal System R-HSA-112316 3.767510e-02 1.424 0 0
Death Receptor Signaling R-HSA-73887 3.320555e-02 1.479 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 3.634995e-02 1.439 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 4.067802e-02 1.391 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 3.628499e-02 1.440 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.389030e-02 1.470 0 0
STING mediated induction of host immune responses R-HSA-1834941 3.634995e-02 1.439 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.636339e-02 1.439 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 3.662973e-02 1.436 0 0
Sensory processing of sound R-HSA-9659379 3.484500e-02 1.458 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 3.748727e-02 1.426 0 0
SARS-CoV-1 Infection R-HSA-9678108 3.313338e-02 1.480 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 4.107624e-02 1.386 0 0
Gap junction degradation R-HSA-190873 4.107624e-02 1.386 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.107624e-02 1.386 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.116760e-02 1.385 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 4.154567e-02 1.381 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 4.423060e-02 1.354 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 4.424508e-02 1.354 0 0
Formation of definitive endoderm R-HSA-9823730 4.424508e-02 1.354 0 0
Nephrin family interactions R-HSA-373753 4.424508e-02 1.354 0 0
SARS-CoV Infections R-HSA-9679506 4.448192e-02 1.352 0 0
AURKA Activation by TPX2 R-HSA-8854518 4.501386e-02 1.347 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 4.556679e-02 1.341 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.584844e-02 1.339 0 0
Signaling by EGFR R-HSA-177929 4.621654e-02 1.335 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.645642e-02 1.333 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 4.645642e-02 1.333 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.666332e-02 1.331 0 0
G2/M Transition R-HSA-69275 4.681200e-02 1.330 0 0
Eukaryotic Translation Termination R-HSA-72764 4.698127e-02 1.328 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 4.826492e-02 1.316 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 4.826492e-02 1.316 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 4.826492e-02 1.316 0 0
Transmission across Chemical Synapses R-HSA-112315 4.846890e-02 1.315 0 0
Selenocysteine synthesis R-HSA-2408557 4.954859e-02 1.305 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 5.188167e-02 1.285 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 5.188167e-02 1.285 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.188167e-02 1.285 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.188167e-02 1.285 0 0
Neurexins and neuroligins R-HSA-6794361 5.224893e-02 1.282 0 0
Mitotic G2-G2/M phases R-HSA-453274 5.275520e-02 1.278 0 0
Ca-dependent events R-HSA-111996 5.275967e-02 1.278 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 5.319111e-02 1.274 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 5.319111e-02 1.274 0 0
ERK/MAPK targets R-HSA-198753 5.319111e-02 1.274 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 5.424179e-02 1.266 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 5.424179e-02 1.266 0 0
Regulation of CDH11 function R-HSA-9762292 5.424179e-02 1.266 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 5.424179e-02 1.266 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 5.435075e-02 1.265 0 0
Organelle biogenesis and maintenance R-HSA-1852241 5.512282e-02 1.259 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 5.597634e-02 1.252 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 5.635751e-02 1.249 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 5.635751e-02 1.249 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 5.637629e-02 1.249 0 0
Regulation of gap junction activity R-HSA-191650 6.810930e-02 1.167 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 6.810930e-02 1.167 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 6.810930e-02 1.167 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 6.810930e-02 1.167 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 7.234507e-02 1.141 0 0
IFNG signaling activates MAPKs R-HSA-9732724 7.234507e-02 1.141 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 6.957822e-02 1.158 0 0
Chaperone Mediated Autophagy R-HSA-9613829 7.074114e-02 1.150 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 6.321935e-02 1.199 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 6.321935e-02 1.199 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 7.623174e-02 1.118 0 0
Downstream signal transduction R-HSA-186763 6.721856e-02 1.173 0 0
MITF-M-dependent gene expression R-HSA-9856651 7.642727e-02 1.117 0 0
Signaling by FGFR4 R-HSA-5654743 5.962252e-02 1.225 0 0
Adipogenesis R-HSA-9843745 5.839391e-02 1.234 0 0
Aggrephagy R-HSA-9646399 6.762338e-02 1.170 0 0
Signaling by FGFR3 R-HSA-5654741 7.508226e-02 1.124 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 6.307076e-02 1.200 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 6.583290e-02 1.182 0 0
mTORC1-mediated signalling R-HSA-166208 7.434914e-02 1.129 0 0
Gap junction trafficking and regulation R-HSA-157858 6.616550e-02 1.179 0 0
Oncogene Induced Senescence R-HSA-2559585 6.773373e-02 1.169 0 0
Mitotic Prophase R-HSA-68875 7.502605e-02 1.125 0 0
S Phase R-HSA-69242 6.762642e-02 1.170 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 6.957822e-02 1.158 0 0
Calmodulin induced events R-HSA-111933 7.683784e-02 1.114 0 0
CaM pathway R-HSA-111997 7.683784e-02 1.114 0 0
Signaling by Nuclear Receptors R-HSA-9006931 6.029464e-02 1.220 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 6.583290e-02 1.182 0 0
Suppression of apoptosis R-HSA-9635465 6.957822e-02 1.158 0 0
Protein-protein interactions at synapses R-HSA-6794362 6.110079e-02 1.214 0 0
HIV Life Cycle R-HSA-162587 5.880536e-02 1.231 0 0
Chromatin modifying enzymes R-HSA-3247509 7.633720e-02 1.117 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 7.074114e-02 1.150 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 6.492145e-02 1.188 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 7.616240e-02 1.118 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 6.321935e-02 1.199 0 0
Kinesins R-HSA-983189 7.044113e-02 1.152 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 7.623174e-02 1.118 0 0
MECP2 regulates transcription factors R-HSA-9022707 7.234507e-02 1.141 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 7.508226e-02 1.124 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 6.321935e-02 1.199 0 0
Apoptotic factor-mediated response R-HSA-111471 7.074114e-02 1.150 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 7.616240e-02 1.118 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 5.935566e-02 1.227 0 0
Signaling by WNT in cancer R-HSA-4791275 7.694150e-02 1.114 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 7.874273e-02 1.104 0 0
Spry regulation of FGF signaling R-HSA-1295596 7.882002e-02 1.103 0 0
Erythropoietin activates RAS R-HSA-9027284 7.882002e-02 1.103 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 7.882002e-02 1.103 0 0
p75NTR signals via NF-kB R-HSA-193639 7.882002e-02 1.103 0 0
DCC mediated attractive signaling R-HSA-418885 7.882002e-02 1.103 0 0
Defective Base Excision Repair Associated with OGG1 R-HSA-9656249 7.998718e-02 1.097 0 0
Breakdown of the nuclear lamina R-HSA-352238 7.998718e-02 1.097 0 0
Oligomerization of connexins into connexons R-HSA-190704 7.998718e-02 1.097 0 0
Transport of connexins along the secretory pathway R-HSA-190827 7.998718e-02 1.097 0 0
Transport of glycerol from adipocytes to the liver by Aquaporins R-HSA-432030 7.998718e-02 1.097 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 8.163433e-02 1.088 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 8.369919e-02 1.077 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 8.396776e-02 1.076 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 8.433038e-02 1.074 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 8.442981e-02 1.074 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 8.524983e-02 1.069 0 0
tRNA processing in the nucleus R-HSA-6784531 8.524983e-02 1.069 0 0
Heme signaling R-HSA-9707616 8.524983e-02 1.069 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 8.658762e-02 1.063 0 0
Growth hormone receptor signaling R-HSA-982772 8.658762e-02 1.063 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 8.667619e-02 1.062 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.705532e-02 1.060 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 8.705532e-02 1.060 0 0
NF-kB is activated and signals survival R-HSA-209560 8.705532e-02 1.060 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.705532e-02 1.060 0 0
G-protein beta:gamma signalling R-HSA-397795 8.749354e-02 1.058 0 0
Viral mRNA Translation R-HSA-192823 8.770269e-02 1.057 0 0
Membrane Trafficking R-HSA-199991 8.776006e-02 1.057 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 8.804877e-02 1.055 0 0
Glucose metabolism R-HSA-70326 8.919181e-02 1.050 0 0
Chromatin organization R-HSA-4839726 8.934450e-02 1.049 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 9.024233e-02 1.045 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 9.037376e-02 1.044 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 9.044430e-02 1.044 0 0
Opioid Signalling R-HSA-111885 9.406239e-02 1.027 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 9.474631e-02 1.023 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 9.689113e-02 1.014 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 9.689113e-02 1.014 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 9.689113e-02 1.014 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 9.689113e-02 1.014 0 0
IRS activation R-HSA-74713 9.689113e-02 1.014 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 9.689113e-02 1.014 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 9.689113e-02 1.014 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.438035e-01 0.842 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.438035e-01 0.842 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.438035e-01 0.842 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.438035e-01 0.842 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.438035e-01 0.842 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.438035e-01 0.842 0 0
Defective OGG1 Substrate Binding R-HSA-9656255 1.438035e-01 0.842 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.438035e-01 0.842 0 0
Defective OGG1 Localization R-HSA-9657050 1.438035e-01 0.842 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.438035e-01 0.842 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.438035e-01 0.842 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.438035e-01 0.842 0 0
mRNA Editing: A to I Conversion R-HSA-75064 1.288487e-01 0.890 0 0
Regulation of TP53 Expression R-HSA-6804754 1.288487e-01 0.890 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.288487e-01 0.890 0 0
C6 deamination of adenosine R-HSA-75102 1.288487e-01 0.890 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.288487e-01 0.890 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.288487e-01 0.890 0 0
Signaling by RAS GAP mutants R-HSA-9753510 1.288487e-01 0.890 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.297051e-01 0.887 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 1.297051e-01 0.887 0 0
Phosphorylation of Emi1 R-HSA-176417 1.297051e-01 0.887 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.189702e-01 0.925 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.189702e-01 0.925 0 0
WNT mediated activation of DVL R-HSA-201688 1.189702e-01 0.925 0 0
ALK mutants bind TKIs R-HSA-9700645 1.189702e-01 0.925 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.065961e-01 0.972 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.065961e-01 0.972 0 0
Polymerase switching R-HSA-69091 1.065961e-01 0.972 0 0
Leading Strand Synthesis R-HSA-69109 1.065961e-01 0.972 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 1.461138e-01 0.835 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.461138e-01 0.835 0 0
MAPK3 (ERK1) activation R-HSA-110056 1.461138e-01 0.835 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 1.461138e-01 0.835 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.461138e-01 0.835 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.122587e-01 0.950 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.122587e-01 0.950 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 9.851169e-02 1.007 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 9.851169e-02 1.007 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 9.851169e-02 1.007 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 9.851169e-02 1.007 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.312870e-01 0.882 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.312870e-01 0.882 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.143450e-01 0.942 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.143450e-01 0.942 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 9.992964e-02 1.000 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 9.992964e-02 1.000 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 9.992964e-02 1.000 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.298443e-01 0.887 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 1.298443e-01 0.887 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 1.298443e-01 0.887 0 0
Dual Incision in GG-NER R-HSA-5696400 1.110834e-01 0.954 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.272676e-01 0.895 0 0
Trafficking of AMPA receptors R-HSA-399719 1.272676e-01 0.895 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.463490e-01 0.835 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.463490e-01 0.835 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.463490e-01 0.835 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.423154e-01 0.847 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 9.963169e-02 1.002 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.251377e-01 0.903 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.349486e-01 0.870 0 0
PKR-mediated signaling R-HSA-9833482 9.893232e-02 1.005 0 0
Mitophagy R-HSA-5205647 1.110834e-01 0.954 0 0
Nucleotide Excision Repair R-HSA-5696398 1.076641e-01 0.968 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.360158e-01 0.866 0 0
IGF1R signaling cascade R-HSA-2428924 1.019240e-01 0.992 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.068837e-01 0.971 0 0
Insulin receptor signalling cascade R-HSA-74751 1.019240e-01 0.992 0 0
DNA Damage Bypass R-HSA-73893 1.131505e-01 0.946 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 1.170577e-01 0.932 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.065961e-01 0.972 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.463490e-01 0.835 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 9.872104e-02 1.006 0 0
HSF1-dependent transactivation R-HSA-3371571 1.357614e-01 0.867 0 0
Receptor Mediated Mitophagy R-HSA-8934903 1.461138e-01 0.835 0 0
Gap junction trafficking R-HSA-190828 1.169169e-01 0.932 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 1.109658e-01 0.955 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.353383e-01 0.869 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.272676e-01 0.895 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 1.297051e-01 0.887 0 0
DNA strand elongation R-HSA-69190 1.423154e-01 0.847 0 0
Interferon Signaling R-HSA-913531 1.317127e-01 0.880 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.250981e-01 0.903 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 1.189702e-01 0.925 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.065961e-01 0.972 0 0
Platelet calcium homeostasis R-HSA-418360 9.987730e-02 1.001 0 0
DAG and IP3 signaling R-HSA-1489509 1.287458e-01 0.890 0 0
Regulation of CDH1 Function R-HSA-9764561 1.418411e-01 0.848 0 0
Signaling by LTK R-HSA-9842663 1.065961e-01 0.972 0 0
GPER1 signaling R-HSA-9634597 1.027332e-01 0.988 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.189702e-01 0.925 0 0
Tight junction interactions R-HSA-420029 1.143581e-01 0.942 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.131126e-01 0.946 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 9.987730e-02 1.001 0 0
TBC/RABGAPs R-HSA-8854214 1.057381e-01 0.976 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.198736e-01 0.921 0 0
Signal transduction by L1 R-HSA-445144 9.851169e-02 1.007 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.065961e-01 0.972 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.111725e-01 0.954 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.111725e-01 0.954 0 0
Cell-cell junction organization R-HSA-421270 1.254770e-01 0.901 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.333562e-01 0.875 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.241040e-01 0.906 0 0
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization R-HSA-180897 1.288487e-01 0.890 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 1.297051e-01 0.887 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.461138e-01 0.835 0 0
FLT3 signaling in disease R-HSA-9682385 1.379192e-01 0.860 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.068155e-01 0.971 0 0
Ion transport by P-type ATPases R-HSA-936837 1.019240e-01 0.992 0 0
Interleukin-1 processing R-HSA-448706 1.189702e-01 0.925 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.304806e-01 0.884 0 0
Signaling by Leptin R-HSA-2586552 1.461138e-01 0.835 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.489953e-01 0.827 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.496880e-01 0.825 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 1.496880e-01 0.825 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 1.496880e-01 0.825 0 0
Signaling by KIT in disease R-HSA-9669938 1.496880e-01 0.825 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.513652e-01 0.820 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.513652e-01 0.820 0 0
Signal regulatory protein family interactions R-HSA-391160 1.513652e-01 0.820 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 1.517401e-01 0.819 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.517401e-01 0.819 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 1.517401e-01 0.819 0 0
Tie2 Signaling R-HSA-210993 1.517401e-01 0.819 0 0
G1/S Transition R-HSA-69206 1.522995e-01 0.817 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 1.543014e-01 0.812 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.553895e-01 0.809 0 0
Centrosome maturation R-HSA-380287 1.558427e-01 0.807 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.582214e-01 0.801 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.582214e-01 0.801 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.582214e-01 0.801 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 1.582214e-01 0.801 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.590826e-01 0.798 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.631001e-01 0.788 0 0
HIV elongation arrest and recovery R-HSA-167287 1.638226e-01 0.786 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.638226e-01 0.786 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 1.638226e-01 0.786 0 0
Neutrophil degranulation R-HSA-6798695 1.639722e-01 0.785 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 1.657986e-01 0.780 0 0
Signaling by LTK in cancer R-HSA-9842640 1.657986e-01 0.780 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 1.657986e-01 0.780 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 1.657986e-01 0.780 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 1.657986e-01 0.780 0 0
Nef and signal transduction R-HSA-164944 1.657986e-01 0.780 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.661168e-01 0.780 0 0
Signaling by NOTCH1 R-HSA-1980143 1.669096e-01 0.778 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.679920e-01 0.775 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.723978e-01 0.763 0 0
Germ layer formation at gastrulation R-HSA-9754189 1.735081e-01 0.761 0 0
The NLRP3 inflammasome R-HSA-844456 1.735081e-01 0.761 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.748588e-01 0.757 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.749440e-01 0.757 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.749440e-01 0.757 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.753936e-01 0.756 0 0
PECAM1 interactions R-HSA-210990 1.753936e-01 0.756 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 1.762644e-01 0.754 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 1.762644e-01 0.754 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.762644e-01 0.754 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.762644e-01 0.754 0 0
SHC1 events in EGFR signaling R-HSA-180336 1.762644e-01 0.754 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.762644e-01 0.754 0 0
Formation of the anterior neural plate R-HSA-9823739 1.762644e-01 0.754 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.790021e-01 0.747 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.790021e-01 0.747 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.790021e-01 0.747 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.790021e-01 0.747 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.790021e-01 0.747 0 0
Ribosome-associated quality control R-HSA-9948299 1.799283e-01 0.745 0 0
Developmental Biology R-HSA-1266738 1.800328e-01 0.745 0 0
Signaling by Erythropoietin R-HSA-9006335 1.822068e-01 0.739 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 1.822068e-01 0.739 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.822611e-01 0.739 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.826858e-01 0.738 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.826858e-01 0.738 0 0
Invadopodia formation R-HSA-8941237 1.826858e-01 0.738 0 0
MET activates PTPN11 R-HSA-8865999 1.826858e-01 0.738 0 0
Classical Kir channels R-HSA-1296053 1.826858e-01 0.738 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 1.826858e-01 0.738 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 1.826858e-01 0.738 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.838603e-01 0.736 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.838603e-01 0.736 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.843655e-01 0.734 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 2.669347e-01 0.574 0 0
Defective OGG1 Substrate Processing R-HSA-9656256 2.669347e-01 0.574 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.669347e-01 0.574 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.669347e-01 0.574 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.669347e-01 0.574 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.669347e-01 0.574 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.669347e-01 0.574 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 2.390583e-01 0.621 0 0
NADE modulates death signalling R-HSA-205025 2.390583e-01 0.621 0 0
HCN channels R-HSA-1296061 2.390583e-01 0.621 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.390583e-01 0.621 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.390583e-01 0.621 0 0
ATP sensitive Potassium channels R-HSA-1296025 2.390583e-01 0.621 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.390583e-01 0.621 0 0
Signaling by MAP2K mutants R-HSA-9652169 2.390583e-01 0.621 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 3.723641e-01 0.429 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 3.723641e-01 0.429 0 0
Mitochondrial transcription initiation R-HSA-163282 3.723641e-01 0.429 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.723641e-01 0.429 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.723641e-01 0.429 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.723641e-01 0.429 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.723641e-01 0.429 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.723641e-01 0.429 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 3.723641e-01 0.429 0 0
Defective SLC12A3 causes Gitelman syndrome (GS) R-HSA-5619087 3.723641e-01 0.429 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 3.723641e-01 0.429 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.723641e-01 0.429 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 3.723641e-01 0.429 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.723641e-01 0.429 0 0
IKBKB deficiency causes SCID R-HSA-5602636 3.723641e-01 0.429 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 3.723641e-01 0.429 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 3.723641e-01 0.429 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 3.723641e-01 0.429 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 3.723641e-01 0.429 0 0
Defective CD320 causes MMATC R-HSA-3359485 3.723641e-01 0.429 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 2.044084e-01 0.690 0 0
Netrin mediated repulsion signals R-HSA-418886 2.044084e-01 0.690 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.044084e-01 0.690 0 0
TRIF-mediated programmed cell death R-HSA-2562578 2.044084e-01 0.690 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.044084e-01 0.690 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.044084e-01 0.690 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.961247e-01 0.529 0 0
Activation of AKT2 R-HSA-165158 2.961247e-01 0.529 0 0
Type I hemidesmosome assembly R-HSA-446107 2.447993e-01 0.611 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 2.447993e-01 0.611 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 2.447993e-01 0.611 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.064609e-01 0.685 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 2.025833e-01 0.693 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.025833e-01 0.693 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 2.025833e-01 0.693 0 0
Phosphorylation of the APC/C R-HSA-176412 2.025833e-01 0.693 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.025833e-01 0.693 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.025833e-01 0.693 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.389565e-01 0.622 0 0
Repression of WNT target genes R-HSA-4641265 2.389565e-01 0.622 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.389565e-01 0.622 0 0
Regulation of IFNG signaling R-HSA-877312 2.389565e-01 0.622 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 2.862898e-01 0.543 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 2.862898e-01 0.543 0 0
MAPK1 (ERK2) activation R-HSA-112411 2.862898e-01 0.543 0 0
CASP8 activity is inhibited R-HSA-5218900 2.862898e-01 0.543 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 3.525201e-01 0.453 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 3.525201e-01 0.453 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 3.525201e-01 0.453 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 3.525201e-01 0.453 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 3.525201e-01 0.453 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 3.525201e-01 0.453 0 0
Signaling by RNF43 mutants R-HSA-5340588 3.525201e-01 0.453 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 1.964666e-01 0.707 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 2.725233e-01 0.565 0 0
Formation of axial mesoderm R-HSA-9796292 2.725233e-01 0.565 0 0
Adenylate cyclase activating pathway R-HSA-170660 2.725233e-01 0.565 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.204795e-01 0.657 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 2.204795e-01 0.657 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 3.282672e-01 0.484 0 0
2-LTR circle formation R-HSA-164843 3.282672e-01 0.484 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.586304e-01 0.587 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 2.586304e-01 0.587 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.586304e-01 0.587 0 0
TGFBR3 expression R-HSA-9839394 2.108226e-01 0.676 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.108226e-01 0.676 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 2.014357e-01 0.696 0 0
Activation of the pre-replicative complex R-HSA-68962 2.014357e-01 0.696 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 2.454027e-01 0.610 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 2.454027e-01 0.610 0 0
NRIF signals cell death from the nucleus R-HSA-205043 3.068159e-01 0.513 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 3.068159e-01 0.513 0 0
CRMPs in Sema3A signaling R-HSA-399956 3.068159e-01 0.513 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.879216e-01 0.541 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.710867e-01 0.567 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 3.701947e-01 0.432 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 3.701947e-01 0.432 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 3.701947e-01 0.432 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 2.005541e-01 0.698 0 0
HIV Transcription Elongation R-HSA-167169 2.005541e-01 0.698 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 2.005541e-01 0.698 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.005541e-01 0.698 0 0
Translesion synthesis by REV1 R-HSA-110312 3.415074e-01 0.467 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 3.177686e-01 0.498 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 2.070952e-01 0.684 0 0
Nucleosome assembly R-HSA-774815 2.070952e-01 0.684 0 0
Interleukin receptor SHC signaling R-HSA-912526 2.973801e-01 0.527 0 0
G alpha (z) signalling events R-HSA-418597 1.877410e-01 0.726 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 2.794533e-01 0.554 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.794533e-01 0.554 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.794533e-01 0.554 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.236228e-01 0.650 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 3.034946e-01 0.518 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 3.034946e-01 0.518 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 3.241318e-01 0.489 0 0
Deadenylation of mRNA R-HSA-429947 3.241318e-01 0.489 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.445399e-01 0.612 0 0
Signaling by ERBB4 R-HSA-1236394 2.125748e-01 0.672 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.279309e-01 0.484 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 3.301540e-01 0.481 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 3.301540e-01 0.481 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 3.314012e-01 0.480 0 0
Dual incision in TC-NER R-HSA-6782135 3.314012e-01 0.480 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 3.129713e-01 0.504 0 0
Developmental Cell Lineages R-HSA-9734767 3.405601e-01 0.468 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.339708e-01 0.631 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 3.465050e-01 0.460 0 0
Regulation of mitotic cell cycle R-HSA-453276 3.465050e-01 0.460 0 0
Co-inhibition by PD-1 R-HSA-389948 2.669080e-01 0.574 0 0
Chromosome Maintenance R-HSA-73886 2.142874e-01 0.669 0 0
Generation of second messenger molecules R-HSA-202433 3.102011e-01 0.508 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.973477e-01 0.527 0 0
DNA Double Strand Break Response R-HSA-5693606 2.811602e-01 0.551 0 0
Extension of Telomeres R-HSA-180786 3.495693e-01 0.456 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.879216e-01 0.541 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.489558e-01 0.604 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 2.799762e-01 0.553 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.119112e-01 0.506 0 0
Lagging Strand Synthesis R-HSA-69186 2.204795e-01 0.657 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.020353e-01 0.695 0 0
Signaling by FGFR1 R-HSA-5654736 2.020353e-01 0.695 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 2.178669e-01 0.662 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.421304e-01 0.616 0 0
Termination of translesion DNA synthesis R-HSA-5656169 3.034946e-01 0.518 0 0
IRS-mediated signalling R-HSA-112399 3.134413e-01 0.504 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 3.527312e-01 0.453 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.253179e-01 0.647 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 3.097860e-01 0.509 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 3.527312e-01 0.453 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 2.204168e-01 0.657 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 2.973801e-01 0.527 0 0
Activation of GABAB receptors R-HSA-991365 2.541516e-01 0.595 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 2.634356e-01 0.579 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 3.298492e-01 0.482 0 0
Interleukin-2 family signaling R-HSA-451927 2.005541e-01 0.698 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.633184e-01 0.440 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 2.559196e-01 0.592 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 2.725233e-01 0.565 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 2.108226e-01 0.676 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 2.689364e-01 0.570 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 2.586304e-01 0.587 0 0
Gap junction assembly R-HSA-190861 3.075352e-01 0.512 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 2.447993e-01 0.611 0 0
Formation of lateral plate mesoderm R-HSA-9758920 3.525201e-01 0.453 0 0
Interleukin-6 signaling R-HSA-1059683 2.725233e-01 0.565 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 3.102011e-01 0.508 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.924350e-01 0.716 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 2.862898e-01 0.543 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 3.068159e-01 0.513 0 0
GABA B receptor activation R-HSA-977444 2.541516e-01 0.595 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 3.495693e-01 0.456 0 0
Activation of HOX genes during differentiation R-HSA-5619507 3.495693e-01 0.456 0 0
Dopamine receptors R-HSA-390651 2.390583e-01 0.621 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 2.025833e-01 0.693 0 0
Synaptic adhesion-like molecules R-HSA-8849932 2.879216e-01 0.541 0 0
Translesion Synthesis by POLH R-HSA-110320 3.177686e-01 0.498 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 3.135627e-01 0.504 0 0
PTEN Regulation R-HSA-6807070 2.455607e-01 0.610 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.106405e-01 0.676 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.301112e-01 0.638 0 0
HSF1 activation R-HSA-3371511 3.530350e-01 0.452 0 0
Signaling by WNT R-HSA-195721 1.875912e-01 0.727 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.151979e-01 0.667 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.476299e-01 0.606 0 0
Cellular response to chemical stress R-HSA-9711123 1.895256e-01 0.722 0 0
Cellular response to starvation R-HSA-9711097 3.284101e-01 0.484 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.048888e-01 0.688 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 2.961247e-01 0.529 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 2.961247e-01 0.529 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.961247e-01 0.529 0 0
GRB2 events in EGFR signaling R-HSA-179812 2.389565e-01 0.622 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 2.862898e-01 0.543 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.964666e-01 0.707 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 3.119112e-01 0.506 0 0
HIV Infection R-HSA-162906 1.985322e-01 0.702 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 3.511937e-01 0.454 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 3.511937e-01 0.454 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 2.005541e-01 0.698 0 0
Diseases of Immune System R-HSA-5260271 2.005541e-01 0.698 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 2.330060e-01 0.633 0 0
rRNA processing R-HSA-72312 1.912084e-01 0.718 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 2.330060e-01 0.633 0 0
Host Interactions of HIV factors R-HSA-162909 2.459656e-01 0.609 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 1.894760e-01 0.722 0 0
Regulation of KIT signaling R-HSA-1433559 3.068159e-01 0.513 0 0
MET activates RAS signaling R-HSA-8851805 2.389565e-01 0.622 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.525201e-01 0.453 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 3.415074e-01 0.467 0 0
Cilium Assembly R-HSA-5617833 2.878371e-01 0.541 0 0
Cardiogenesis R-HSA-9733709 2.634356e-01 0.579 0 0
Adherens junctions interactions R-HSA-418990 2.218352e-01 0.654 0 0
Regulation of gene expression in beta cells R-HSA-210745 3.034946e-01 0.518 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 2.961247e-01 0.529 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 2.447993e-01 0.611 0 0
Rap1 signalling R-HSA-392517 3.177686e-01 0.498 0 0
Regulation of necroptotic cell death R-HSA-5675482 2.634356e-01 0.579 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.668555e-01 0.574 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.966325e-01 0.528 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 2.973801e-01 0.527 0 0
Early Phase of HIV Life Cycle R-HSA-162594 2.204795e-01 0.657 0 0
Specification of the neural plate border R-HSA-9834899 3.177686e-01 0.498 0 0
HDMs demethylate histones R-HSA-3214842 2.108226e-01 0.676 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 2.520425e-01 0.599 0 0
DAP12 interactions R-HSA-2172127 1.911137e-01 0.719 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.259039e-01 0.646 0 0
Inhibition of PKR R-HSA-169131 2.669347e-01 0.574 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.390583e-01 0.621 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 2.390583e-01 0.621 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 3.723641e-01 0.429 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.723641e-01 0.429 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.961247e-01 0.529 0 0
RSK activation R-HSA-444257 2.447993e-01 0.611 0 0
Unwinding of DNA R-HSA-176974 2.862898e-01 0.543 0 0
Metalloprotease DUBs R-HSA-5689901 2.330060e-01 0.633 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.879216e-01 0.541 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 1.974347e-01 0.705 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.799762e-01 0.553 0 0
Interleukin-1 family signaling R-HSA-446652 2.649161e-01 0.577 0 0
Pexophagy R-HSA-9664873 3.282672e-01 0.484 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.541516e-01 0.595 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.862898e-01 0.543 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 3.701947e-01 0.432 0 0
PI Metabolism R-HSA-1483255 2.331668e-01 0.632 0 0
Hemostasis R-HSA-109582 2.154537e-01 0.667 0 0
Formation of the nephric duct R-HSA-9830364 3.511937e-01 0.454 0 0
Adrenoceptors R-HSA-390696 2.447993e-01 0.611 0 0
OAS antiviral response R-HSA-8983711 2.389565e-01 0.622 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 3.525201e-01 0.453 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 3.525201e-01 0.453 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 3.415074e-01 0.467 0 0
Syndecan interactions R-HSA-3000170 2.973801e-01 0.527 0 0
RAB geranylgeranylation R-HSA-8873719 2.636302e-01 0.579 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.668555e-01 0.574 0 0
Ion channel transport R-HSA-983712 2.783823e-01 0.555 1 0
Maturation of nucleoprotein R-HSA-9694631 3.177686e-01 0.498 0 0
Other interleukin signaling R-HSA-449836 3.177686e-01 0.498 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 2.044084e-01 0.690 0 0
TRAIL signaling R-HSA-75158 3.525201e-01 0.453 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 2.689364e-01 0.570 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 2.389565e-01 0.622 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 3.525201e-01 0.453 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 3.415074e-01 0.467 0 0
Signaling by ALK R-HSA-201556 2.893750e-01 0.539 0 0
G1/S-Specific Transcription R-HSA-69205 3.530350e-01 0.452 0 0
Inositol phosphate metabolism R-HSA-1483249 2.234263e-01 0.651 0 0
Signaling by FGFR4 in disease R-HSA-5655291 3.068159e-01 0.513 0 0
Diseases of Base Excision Repair R-HSA-9605308 3.525201e-01 0.453 0 0
NTRK3 as a dependence receptor R-HSA-9603505 3.723641e-01 0.429 0 0
Co-inhibition by BTLA R-HSA-9927353 2.961247e-01 0.529 0 0
NrCAM interactions R-HSA-447038 2.961247e-01 0.529 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 2.064609e-01 0.685 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 3.525201e-01 0.453 0 0
TRP channels R-HSA-3295583 2.330060e-01 0.633 1 1
RUNX2 regulates genes involved in cell migration R-HSA-8941332 3.701947e-01 0.432 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 2.879216e-01 0.541 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.742928e-01 0.427 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 3.756362e-01 0.425 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 3.762955e-01 0.424 0 0
Translesion synthesis by POLI R-HSA-5656121 3.762955e-01 0.424 0 0
Phase 4 - resting membrane potential R-HSA-5576886 3.762955e-01 0.424 0 0
Activation of SMO R-HSA-5635838 3.762955e-01 0.424 0 0
Prolonged ERK activation events R-HSA-169893 3.762955e-01 0.424 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 3.762955e-01 0.424 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 3.762955e-01 0.424 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 3.783022e-01 0.422 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 3.783022e-01 0.422 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 3.784222e-01 0.422 0 0
Signaling by FGFR2 R-HSA-5654738 3.936954e-01 0.405 0 0
Response of Mtb to phagocytosis R-HSA-9637690 3.959591e-01 0.402 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 3.992383e-01 0.399 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 4.024271e-01 0.395 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 4.025048e-01 0.395 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 4.048900e-01 0.393 0 0
NCAM signaling for neurite out-growth R-HSA-375165 4.048900e-01 0.393 0 0
Stimuli-sensing channels R-HSA-2672351 4.055979e-01 0.392 1 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.056803e-01 0.392 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 4.056803e-01 0.392 0 0
CREB phosphorylation R-HSA-199920 4.072577e-01 0.390 0 0
STAT5 Activation R-HSA-9645135 4.072577e-01 0.390 0 0
G2/M DNA replication checkpoint R-HSA-69478 4.072577e-01 0.390 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 4.072577e-01 0.390 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 4.072577e-01 0.390 0 0
NADPH regeneration R-HSA-389542 4.072577e-01 0.390 0 0
Abacavir transmembrane transport R-HSA-2161517 4.072577e-01 0.390 0 0
TCF dependent signaling in response to WNT R-HSA-201681 4.080096e-01 0.389 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 4.086030e-01 0.389 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 4.086030e-01 0.389 0 0
Mitochondrial calcium ion transport R-HSA-8949215 4.086030e-01 0.389 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.089422e-01 0.388 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 4.109056e-01 0.386 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 4.109056e-01 0.386 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 4.109056e-01 0.386 0 0
Translesion synthesis by POLK R-HSA-5655862 4.109056e-01 0.386 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 4.109056e-01 0.386 0 0
Passive transport by Aquaporins R-HSA-432047 4.109056e-01 0.386 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 4.109056e-01 0.386 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 4.109056e-01 0.386 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.116133e-01 0.386 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.116133e-01 0.386 0 0
Integration of provirus R-HSA-162592 4.116133e-01 0.386 0 0
G1 Phase R-HSA-69236 4.176619e-01 0.379 0 0
Cyclin D associated events in G1 R-HSA-69231 4.176619e-01 0.379 0 0
Signaling by TGFB family members R-HSA-9006936 4.223685e-01 0.374 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 4.223941e-01 0.374 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.262219e-01 0.370 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 4.274329e-01 0.369 0 0
Effects of PIP2 hydrolysis R-HSA-114508 4.274329e-01 0.369 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 4.328390e-01 0.364 0 0
Formation of the Early Elongation Complex R-HSA-113418 4.328390e-01 0.364 0 0
Inflammasomes R-HSA-622312 4.328390e-01 0.364 0 0
TCR signaling R-HSA-202403 4.339563e-01 0.363 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 4.365913e-01 0.360 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 4.365913e-01 0.360 0 0
Ub-specific processing proteases R-HSA-5689880 4.376289e-01 0.359 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 4.386919e-01 0.358 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 4.386919e-01 0.358 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 4.386919e-01 0.358 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 4.386919e-01 0.358 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 4.386919e-01 0.358 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 4.386919e-01 0.358 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 4.393357e-01 0.357 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 4.393357e-01 0.357 0 0
HATs acetylate histones R-HSA-3214847 4.434701e-01 0.353 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 4.450931e-01 0.352 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 4.450931e-01 0.352 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 4.450931e-01 0.352 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 4.450931e-01 0.352 0 0
Specification of primordial germ cells R-HSA-9827857 4.450931e-01 0.352 0 0
Attenuation phase R-HSA-3371568 4.454803e-01 0.351 0 0
Platelet degranulation R-HSA-114608 4.475036e-01 0.349 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 4.489703e-01 0.348 0 0
IRAK1 recruits IKK complex R-HSA-937039 4.521404e-01 0.345 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 4.521404e-01 0.345 0 0
Interleukin-15 signaling R-HSA-8983432 4.521404e-01 0.345 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 4.521404e-01 0.345 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 4.521404e-01 0.345 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 4.521404e-01 0.345 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 4.521404e-01 0.345 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 4.522322e-01 0.345 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 4.522322e-01 0.345 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 4.541014e-01 0.343 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 4.596481e-01 0.338 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 4.596481e-01 0.338 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 4.596481e-01 0.338 0 0
Disinhibition of SNARE formation R-HSA-114516 4.596481e-01 0.338 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 4.596481e-01 0.338 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 4.596481e-01 0.338 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 4.596481e-01 0.338 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 4.596481e-01 0.338 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 4.596481e-01 0.338 0 0
Late endosomal microautophagy R-HSA-9615710 4.597779e-01 0.337 0 0
Signaling by TGFBR3 R-HSA-9839373 4.609177e-01 0.336 0 0
DSCAM interactions R-HSA-376172 4.626359e-01 0.335 0 0
Signalling to ERK5 R-HSA-198765 4.626359e-01 0.335 0 0
Defective PAPSS2 causes SEMD-PA R-HSA-3560796 4.626359e-01 0.335 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 4.626359e-01 0.335 0 0
Defective SLC12A1 causes Bartter syndrome 1 (BS1) R-HSA-5619104 4.626359e-01 0.335 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 4.626359e-01 0.335 0 0
Potassium transport channels R-HSA-1296067 4.626359e-01 0.335 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.626359e-01 0.335 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.626359e-01 0.335 0 0
Transcription from mitochondrial promoters R-HSA-75944 4.626359e-01 0.335 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 4.626359e-01 0.335 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 4.626359e-01 0.335 0 0
Influenza Virus Induced Apoptosis R-HSA-168277 4.626359e-01 0.335 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 4.626359e-01 0.335 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 4.640022e-01 0.333 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 4.684125e-01 0.329 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 4.684125e-01 0.329 0 0
Selenoamino acid metabolism R-HSA-2408522 4.692813e-01 0.329 0 0
Base Excision Repair R-HSA-73884 4.698513e-01 0.328 0 0
Rab regulation of trafficking R-HSA-9007101 4.710119e-01 0.327 0 0
Meiosis R-HSA-1500620 4.760478e-01 0.322 0 0
GAB1 signalosome R-HSA-180292 4.786441e-01 0.320 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 4.786441e-01 0.320 0 0
PKA activation in glucagon signalling R-HSA-164378 4.786441e-01 0.320 0 0
PKA activation R-HSA-163615 4.786441e-01 0.320 0 0
Gene Silencing by RNA R-HSA-211000 4.822690e-01 0.317 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.863866e-01 0.313 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 4.863866e-01 0.313 0 0
Activation of BH3-only proteins R-HSA-114452 4.863866e-01 0.313 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 4.864475e-01 0.313 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 4.891037e-01 0.311 0 0
Ca2+ pathway R-HSA-4086398 4.896997e-01 0.310 0 0
Signaling by FGFR1 in disease R-HSA-5655302 4.911507e-01 0.309 0 0
Intra-Golgi traffic R-HSA-6811438 4.911507e-01 0.309 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 4.914651e-01 0.309 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 4.914651e-01 0.309 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 4.914651e-01 0.309 0 0
Frs2-mediated activation R-HSA-170968 4.914651e-01 0.309 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 4.914651e-01 0.309 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 4.923980e-01 0.308 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 4.976247e-01 0.303 0 0
Thromboxane signalling through TP receptor R-HSA-428930 4.976247e-01 0.303 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 4.976247e-01 0.303 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 4.976247e-01 0.303 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 5.055391e-01 0.296 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 5.073328e-01 0.295 0 0
Integration of energy metabolism R-HSA-163685 5.073328e-01 0.295 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 5.092343e-01 0.293 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 5.092343e-01 0.293 0 0
Regulation by c-FLIP R-HSA-3371378 5.092343e-01 0.293 0 0
Dimerization of procaspase-8 R-HSA-69416 5.092343e-01 0.293 0 0
phospho-PLA2 pathway R-HSA-111995 5.092343e-01 0.293 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 5.092343e-01 0.293 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 5.092343e-01 0.293 0 0
Interleukin-9 signaling R-HSA-8985947 5.092343e-01 0.293 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 5.092343e-01 0.293 0 0
Alpha-defensins R-HSA-1462054 5.092343e-01 0.293 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 5.113753e-01 0.291 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 5.113753e-01 0.291 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 5.113753e-01 0.291 0 0
EGFR downregulation R-HSA-182971 5.125648e-01 0.290 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.125648e-01 0.290 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 5.135998e-01 0.289 0 0
Transcription of the HIV genome R-HSA-167172 5.154578e-01 0.288 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 5.154578e-01 0.288 0 0
Protein folding R-HSA-391251 5.171259e-01 0.286 0 0
Signaling by Insulin receptor R-HSA-74752 5.171259e-01 0.286 0 0
Signaling by PDGF R-HSA-186797 5.244350e-01 0.280 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 5.245403e-01 0.280 0 0
Chaperonin-mediated protein folding R-HSA-390466 5.247662e-01 0.280 0 0
Regulation of insulin secretion R-HSA-422356 5.250680e-01 0.280 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 5.262051e-01 0.279 0 0
Circadian clock R-HSA-9909396 5.262087e-01 0.279 0 0
Prolactin receptor signaling R-HSA-1170546 5.293428e-01 0.276 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 5.293428e-01 0.276 0 0
Removal of the Flap Intermediate R-HSA-69166 5.293428e-01 0.276 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.293428e-01 0.276 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 5.293428e-01 0.276 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.293428e-01 0.276 0 0
Physiological factors R-HSA-5578768 5.293428e-01 0.276 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 5.293428e-01 0.276 0 0
Epigenetic regulation of gene expression R-HSA-212165 5.326977e-01 0.274 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.342774e-01 0.272 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 5.357098e-01 0.271 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 5.382227e-01 0.269 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 5.399285e-01 0.268 0 0
Axonal growth stimulation R-HSA-209563 5.399285e-01 0.268 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 5.399285e-01 0.268 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 5.399285e-01 0.268 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 5.399285e-01 0.268 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 5.399285e-01 0.268 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 5.399285e-01 0.268 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 5.399285e-01 0.268 0 0
MET interacts with TNS proteins R-HSA-8875513 5.399285e-01 0.268 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 5.399285e-01 0.268 0 0
Intracellular oxygen transport R-HSA-8981607 5.399285e-01 0.268 0 0
Histamine receptors R-HSA-390650 5.399285e-01 0.268 0 0
FasL/ CD95L signaling R-HSA-75157 5.399285e-01 0.268 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 5.431334e-01 0.265 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 5.431334e-01 0.265 0 0
Signaling by NODAL R-HSA-1181150 5.431334e-01 0.265 0 0
PI3K Cascade R-HSA-109704 5.451833e-01 0.263 0 0
Regulation of RAS by GAPs R-HSA-5658442 5.451833e-01 0.263 0 0
Unfolded Protein Response (UPR) R-HSA-381119 5.453204e-01 0.263 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 5.540472e-01 0.256 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 5.540472e-01 0.256 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 5.540472e-01 0.256 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 5.550240e-01 0.256 0 0
ARMS-mediated activation R-HSA-170984 5.557393e-01 0.255 0 0
Interleukin-21 signaling R-HSA-9020958 5.557393e-01 0.255 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 5.557393e-01 0.255 0 0
mRNA Editing R-HSA-75072 5.557393e-01 0.255 0 0
Calcineurin activates NFAT R-HSA-2025928 5.557393e-01 0.255 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 5.557393e-01 0.255 0 0
Cellular response to mitochondrial stress R-HSA-9840373 5.557393e-01 0.255 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 5.557393e-01 0.255 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 5.557393e-01 0.255 0 0
Platelet homeostasis R-HSA-418346 5.614183e-01 0.251 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 5.617370e-01 0.250 0 0
Meiotic recombination R-HSA-912446 5.654806e-01 0.248 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 5.655883e-01 0.247 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.655883e-01 0.247 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 5.655883e-01 0.247 0 0
Protein methylation R-HSA-8876725 5.655883e-01 0.247 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 5.655883e-01 0.247 0 0
Signaling by Activin R-HSA-1502540 5.655883e-01 0.247 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 5.655883e-01 0.247 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 5.655883e-01 0.247 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 5.737930e-01 0.241 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 5.737930e-01 0.241 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 5.737930e-01 0.241 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 5.782863e-01 0.238 0 0
Signaling by FGFR3 in disease R-HSA-5655332 5.810605e-01 0.236 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 5.810605e-01 0.236 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 5.858964e-01 0.232 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 5.876711e-01 0.231 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 5.876711e-01 0.231 0 0
Miscellaneous transport and binding events R-HSA-5223345 5.876711e-01 0.231 0 0
Regulation of beta-cell development R-HSA-186712 5.915749e-01 0.228 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 5.920420e-01 0.228 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 5.920420e-01 0.228 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 5.920420e-01 0.228 0 0
Binding and entry of HIV virion R-HSA-173107 5.990236e-01 0.223 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 5.990236e-01 0.223 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 5.990236e-01 0.223 0 0
PI3K/AKT activation R-HSA-198203 5.990236e-01 0.223 0 0
Josephin domain DUBs R-HSA-5689877 5.990236e-01 0.223 0 0
Interleukin-27 signaling R-HSA-9020956 5.990236e-01 0.223 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 5.990236e-01 0.223 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 5.990236e-01 0.223 0 0
Regulation of the apoptosome activity R-HSA-9627069 5.990236e-01 0.223 0 0
Formation of apoptosome R-HSA-111458 5.990236e-01 0.223 0 0
Killing mechanisms R-HSA-9664420 6.000691e-01 0.222 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.000691e-01 0.222 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 6.000691e-01 0.222 0 0
Negative regulation of FLT3 R-HSA-9706369 6.000691e-01 0.222 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.000691e-01 0.222 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.000691e-01 0.222 0 0
IRE1alpha activates chaperones R-HSA-381070 6.026733e-01 0.220 0 0
Meiotic synapsis R-HSA-1221632 6.048536e-01 0.218 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 6.048536e-01 0.218 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 6.048536e-01 0.218 0 0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine R-HSA-9735763 6.061074e-01 0.217 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 6.061074e-01 0.217 0 0
Nucleotide catabolism defects R-HSA-9735786 6.061074e-01 0.217 0 0
Signaling by LRP5 mutants R-HSA-5339717 6.061074e-01 0.217 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 6.061074e-01 0.217 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 6.061074e-01 0.217 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 6.061074e-01 0.217 0 0
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate R-HSA-2978092 6.061074e-01 0.217 0 0
TNFR1-mediated ceramide production R-HSA-5626978 6.061074e-01 0.217 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 6.061074e-01 0.217 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 6.061074e-01 0.217 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 6.061074e-01 0.217 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 6.061074e-01 0.217 0 0
Telomere Extension By Telomerase R-HSA-171319 6.071703e-01 0.217 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 6.071703e-01 0.217 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 6.071703e-01 0.217 0 0
Telomere Maintenance R-HSA-157579 6.077090e-01 0.216 0 0
GABA receptor activation R-HSA-977443 6.099392e-01 0.215 0 0
Viral Infection Pathways R-HSA-9824446 6.100770e-01 0.215 0 0
Potential therapeutics for SARS R-HSA-9679191 6.110247e-01 0.214 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 6.113346e-01 0.214 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 6.113346e-01 0.214 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 6.125212e-01 0.213 0 0
XBP1(S) activates chaperone genes R-HSA-381038 6.128854e-01 0.213 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 6.197431e-01 0.208 0 0
Leishmania infection R-HSA-9658195 6.209729e-01 0.207 0 0
Parasitic Infection Pathways R-HSA-9824443 6.209729e-01 0.207 0 0
mRNA Capping R-HSA-72086 6.323168e-01 0.199 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 6.326983e-01 0.199 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 6.326983e-01 0.199 0 0
Disorders of Developmental Biology R-HSA-9675151 6.326983e-01 0.199 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 6.326983e-01 0.199 0 0
PERK regulates gene expression R-HSA-381042 6.342231e-01 0.198 0 0
Interferon gamma signaling R-HSA-877300 6.377751e-01 0.195 0 0
MHC class II antigen presentation R-HSA-2132295 6.384648e-01 0.195 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 6.390515e-01 0.194 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 6.390515e-01 0.194 0 0
Formation of the posterior neural plate R-HSA-9832991 6.390515e-01 0.194 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 6.390515e-01 0.194 0 0
Bicarbonate transporters R-HSA-425381 6.390515e-01 0.194 0 0
Ionotropic activity of kainate receptors R-HSA-451306 6.390515e-01 0.194 0 0
Transport of RCbl within the body R-HSA-9758890 6.390515e-01 0.194 0 0
Prostanoid ligand receptors R-HSA-391908 6.390515e-01 0.194 0 0
ChREBP activates metabolic gene expression R-HSA-163765 6.390515e-01 0.194 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 6.423744e-01 0.192 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 6.423744e-01 0.192 0 0
Signaling by NOTCH3 R-HSA-9012852 6.423744e-01 0.192 0 0
FCERI mediated MAPK activation R-HSA-2871796 6.437499e-01 0.191 0 0
Hedgehog 'off' state R-HSA-5610787 6.500286e-01 0.187 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 6.515260e-01 0.186 0 0
UCH proteinases R-HSA-5689603 6.515260e-01 0.186 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 6.562975e-01 0.183 0 0
RNA Polymerase III Transcription R-HSA-74158 6.562975e-01 0.183 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 6.583146e-01 0.182 0 0
TNF signaling R-HSA-75893 6.603720e-01 0.180 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 6.624408e-01 0.179 0 0
Activation of AMPA receptors R-HSA-399710 6.627701e-01 0.179 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 6.627701e-01 0.179 0 0
Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) R-HSA-5619067 6.627701e-01 0.179 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.627701e-01 0.179 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 6.627701e-01 0.179 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 6.627701e-01 0.179 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 6.627701e-01 0.179 0 0
NTRK2 activates RAC1 R-HSA-9032759 6.627701e-01 0.179 0 0
Suppression of autophagy R-HSA-9636569 6.627701e-01 0.179 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.627701e-01 0.179 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 6.627701e-01 0.179 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 6.627701e-01 0.179 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 6.627701e-01 0.179 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.634284e-01 0.178 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.634284e-01 0.178 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 6.634284e-01 0.178 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 6.634284e-01 0.178 0 0
Signaling by NOTCH R-HSA-157118 6.678942e-01 0.175 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 6.694386e-01 0.174 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 6.758641e-01 0.170 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 6.758641e-01 0.170 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 6.758641e-01 0.170 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 6.758641e-01 0.170 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 6.758641e-01 0.170 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 6.758641e-01 0.170 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 6.758641e-01 0.170 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 6.795487e-01 0.168 0 0
Cargo concentration in the ER R-HSA-5694530 6.795487e-01 0.168 0 0
RNA Polymerase I Transcription R-HSA-73864 6.821216e-01 0.166 0 0
Interleukin-6 family signaling R-HSA-6783589 6.838260e-01 0.165 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 6.838260e-01 0.165 0 0
Neurodegenerative Diseases R-HSA-8863678 6.838260e-01 0.165 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.838260e-01 0.165 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.858363e-01 0.164 0 0
Adaptive Immune System R-HSA-1280218 6.864663e-01 0.163 0 0
COPI-mediated anterograde transport R-HSA-6807878 6.878233e-01 0.163 0 0
Signaling by Hedgehog R-HSA-5358351 6.916536e-01 0.160 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 6.922442e-01 0.160 0 0
Mismatch Repair R-HSA-5358508 6.922442e-01 0.160 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 6.947390e-01 0.158 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 6.958030e-01 0.158 0 0
Amine ligand-binding receptors R-HSA-375280 6.958658e-01 0.157 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 6.968128e-01 0.157 0 0
MET promotes cell motility R-HSA-8875878 6.978919e-01 0.156 0 0
Depurination R-HSA-73927 6.978919e-01 0.156 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.015795e-01 0.154 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 7.079659e-01 0.150 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.079659e-01 0.150 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 7.095580e-01 0.149 0 0
Interleukin-35 Signalling R-HSA-8984722 7.095580e-01 0.149 0 0
Disorders of Nervous System Development R-HSA-9697154 7.095580e-01 0.149 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 7.095580e-01 0.149 0 0
Pervasive developmental disorders R-HSA-9005895 7.095580e-01 0.149 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 7.095580e-01 0.149 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 7.095580e-01 0.149 0 0
Signaling by MET R-HSA-6806834 7.110855e-01 0.148 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 7.112844e-01 0.148 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 7.112844e-01 0.148 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 7.112844e-01 0.148 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 7.112844e-01 0.148 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 7.112844e-01 0.148 0 0
Signaling by MAPK mutants R-HSA-9652817 7.112844e-01 0.148 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 7.112844e-01 0.148 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 7.112844e-01 0.148 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 7.112844e-01 0.148 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 7.112844e-01 0.148 0 0
PKB-mediated events R-HSA-109703 7.112844e-01 0.148 0 0
PDE3B signalling R-HSA-165160 7.112844e-01 0.148 0 0
Synthesis of PS R-HSA-1483101 7.112844e-01 0.148 0 0
Ceramide signalling R-HSA-193681 7.112844e-01 0.148 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 7.112844e-01 0.148 0 0
Ligand-receptor interactions R-HSA-5632681 7.112844e-01 0.148 0 0
VEGF ligand-receptor interactions R-HSA-194313 7.112844e-01 0.148 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 7.112844e-01 0.148 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 7.117632e-01 0.148 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 7.121576e-01 0.147 0 0
Leishmania phagocytosis R-HSA-9664417 7.132445e-01 0.147 0 0
Parasite infection R-HSA-9664407 7.132445e-01 0.147 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 7.132445e-01 0.147 0 0
Signaling by FGFR R-HSA-190236 7.137176e-01 0.146 0 0
Fanconi Anemia Pathway R-HSA-6783310 7.141281e-01 0.146 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 7.141281e-01 0.146 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 7.191582e-01 0.143 0 0
E2F mediated regulation of DNA replication R-HSA-113510 7.191582e-01 0.143 0 0
Regulation of signaling by CBL R-HSA-912631 7.191582e-01 0.143 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 7.191582e-01 0.143 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 7.191582e-01 0.143 0 0
Nuclear RNA decay R-HSA-9930044 7.225354e-01 0.141 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 7.287329e-01 0.137 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 7.316374e-01 0.136 0 0
Regulation of TNFR1 signaling R-HSA-5357905 7.316374e-01 0.136 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 7.316374e-01 0.136 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 7.316374e-01 0.136 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 7.359726e-01 0.133 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 7.359726e-01 0.133 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 7.383447e-01 0.132 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 7.392871e-01 0.131 0 0
Vesicle-mediated transport R-HSA-5653656 7.402445e-01 0.131 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 7.402687e-01 0.131 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 7.402687e-01 0.131 0 0
Maturation of nucleoprotein R-HSA-9683610 7.402687e-01 0.131 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 7.402687e-01 0.131 0 0
Aquaporin-mediated transport R-HSA-445717 7.420218e-01 0.130 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 7.424149e-01 0.129 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.442046e-01 0.128 0 0
Protein hydroxylation R-HSA-9629569 7.442046e-01 0.128 0 0
HCMV Early Events R-HSA-9609690 7.455387e-01 0.128 0 0
Interleukin-1 signaling R-HSA-9020702 7.500024e-01 0.125 0 0
Synthesis of DNA R-HSA-69239 7.500888e-01 0.125 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.521439e-01 0.124 0 0
Packaging Of Telomere Ends R-HSA-171306 7.521439e-01 0.124 0 0
Signaling by BMP R-HSA-201451 7.521439e-01 0.124 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 7.521439e-01 0.124 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 7.528218e-01 0.123 0 0
Erythropoietin activates STAT5 R-HSA-9027283 7.528218e-01 0.123 0 0
Autointegration results in viral DNA circles R-HSA-177539 7.528218e-01 0.123 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 7.528218e-01 0.123 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 7.528218e-01 0.123 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 7.528218e-01 0.123 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 7.528218e-01 0.123 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 7.528218e-01 0.123 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 7.528218e-01 0.123 0 0
CREB3 factors activate genes R-HSA-8874211 7.528218e-01 0.123 0 0
HDACs deacetylate histones R-HSA-3214815 7.599041e-01 0.119 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 7.612249e-01 0.118 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 7.612249e-01 0.118 0 0
Signaling by NOTCH2 R-HSA-1980145 7.612249e-01 0.118 0 0
Intraflagellar transport R-HSA-5620924 7.643846e-01 0.117 0 0
NGF-stimulated transcription R-HSA-9031628 7.643846e-01 0.117 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.646453e-01 0.117 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.674350e-01 0.115 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 7.674350e-01 0.115 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.674350e-01 0.115 0 0
Basigin interactions R-HSA-210991 7.674350e-01 0.115 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 7.674350e-01 0.115 0 0
Retrograde neurotrophin signalling R-HSA-177504 7.681568e-01 0.115 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 7.681568e-01 0.115 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 7.681568e-01 0.115 0 0
HDL assembly R-HSA-8963896 7.681568e-01 0.115 0 0
Non-canonical inflammasome activation R-HSA-9686114 7.681568e-01 0.115 0 0
Immune System R-HSA-168256 7.712633e-01 0.113 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 7.722185e-01 0.112 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.722185e-01 0.112 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 7.729334e-01 0.112 0 0
Potassium Channels R-HSA-1296071 7.732580e-01 0.112 0 0
PCP/CE pathway R-HSA-4086400 7.779873e-01 0.109 0 0
Degradation of CDH1 R-HSA-9766229 7.796270e-01 0.108 0 0
Hedgehog 'on' state R-HSA-5632684 7.806315e-01 0.108 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 7.864591e-01 0.104 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 7.864591e-01 0.104 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 7.864591e-01 0.104 0 0
Depyrimidination R-HSA-73928 7.864591e-01 0.104 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 7.883853e-01 0.103 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 7.883853e-01 0.103 0 0
Recycling of eIF2:GDP R-HSA-72731 7.883853e-01 0.103 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 7.883853e-01 0.103 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 7.883853e-01 0.103 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.883853e-01 0.103 0 0
PTK6 Expression R-HSA-8849473 7.883853e-01 0.103 0 0
Cysteine formation from homocysteine R-HSA-1614603 7.883853e-01 0.103 0 0
Ca2+ activated K+ channels R-HSA-1296052 7.883853e-01 0.103 0 0
Regulation of PTEN localization R-HSA-8948747 7.883853e-01 0.103 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 7.883853e-01 0.103 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.883853e-01 0.103 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 7.883853e-01 0.103 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 7.889148e-01 0.103 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.889148e-01 0.103 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 7.889148e-01 0.103 0 0
ER to Golgi Anterograde Transport R-HSA-199977 7.902260e-01 0.102 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 7.933989e-01 0.101 0 0
Telomere C-strand synthesis initiation R-HSA-174430 7.933989e-01 0.101 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 7.933989e-01 0.101 0 0
PRC2 methylates histones and DNA R-HSA-212300 7.956983e-01 0.099 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 7.956983e-01 0.099 0 0
G alpha (q) signalling events R-HSA-416476 8.004180e-01 0.097 0 0
Switching of origins to a post-replicative state R-HSA-69052 8.049446e-01 0.094 0 0
Gastrulation R-HSA-9758941 8.070489e-01 0.093 0 0
Reproduction R-HSA-1474165 8.084476e-01 0.092 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 8.085013e-01 0.092 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 8.087190e-01 0.092 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.087190e-01 0.092 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.087190e-01 0.092 0 0
Voltage gated Potassium channels R-HSA-1296072 8.114073e-01 0.091 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.114073e-01 0.091 0 0
Cleavage of the damaged purine R-HSA-110331 8.114073e-01 0.091 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.161790e-01 0.088 0 0
Regulation of BACH1 activity R-HSA-9708530 8.161790e-01 0.088 0 0
Differentiation of T cells R-HSA-9945266 8.161790e-01 0.088 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.161790e-01 0.088 0 0
Signaling by NOTCH4 R-HSA-9013694 8.163251e-01 0.088 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 8.188337e-01 0.087 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 8.188337e-01 0.087 0 0
MET receptor recycling R-HSA-8875656 8.188337e-01 0.087 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 8.188337e-01 0.087 0 0
FGFR1b ligand binding and activation R-HSA-190370 8.188337e-01 0.087 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 8.188337e-01 0.087 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 8.188337e-01 0.087 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 8.188337e-01 0.087 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 8.188337e-01 0.087 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 8.188337e-01 0.087 0 0
Sodium/Proton exchangers R-HSA-425986 8.188337e-01 0.087 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 8.188337e-01 0.087 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 8.209339e-01 0.086 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 8.209339e-01 0.086 0 0
Budding and maturation of HIV virion R-HSA-162588 8.247954e-01 0.084 0 0
Interleukin-20 family signaling R-HSA-8854691 8.269300e-01 0.083 0 0
Protein ubiquitination R-HSA-8852135 8.271977e-01 0.082 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 8.366827e-01 0.077 0 0
Synthesis of PG R-HSA-1483148 8.366827e-01 0.077 0 0
Downstream TCR signaling R-HSA-202424 8.393728e-01 0.076 0 0
RAS processing R-HSA-9648002 8.399175e-01 0.076 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.399175e-01 0.076 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 8.436344e-01 0.074 0 0
p75NTR regulates axonogenesis R-HSA-193697 8.449025e-01 0.073 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 8.449025e-01 0.073 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 8.449025e-01 0.073 0 0
Lipophagy R-HSA-9613354 8.449025e-01 0.073 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.449025e-01 0.073 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 8.449025e-01 0.073 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 8.449339e-01 0.073 0 0
Interferon alpha/beta signaling R-HSA-909733 8.459295e-01 0.073 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.474557e-01 0.072 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.486169e-01 0.071 0 0
Glycogen metabolism R-HSA-8982491 8.527878e-01 0.069 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.537451e-01 0.069 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 8.539386e-01 0.069 0 0
FGFR1 mutant receptor activation R-HSA-1839124 8.539386e-01 0.069 0 0
Uptake and function of anthrax toxins R-HSA-5210891 8.550935e-01 0.068 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.589217e-01 0.066 0 0
Interleukin-7 signaling R-HSA-1266695 8.589217e-01 0.066 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.589217e-01 0.066 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 8.611491e-01 0.065 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 8.647848e-01 0.063 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 8.647848e-01 0.063 0 0
Gluconeogenesis R-HSA-70263 8.648726e-01 0.063 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.668966e-01 0.062 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.668966e-01 0.062 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 8.672215e-01 0.062 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.672215e-01 0.062 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 8.672215e-01 0.062 0 0
Maturation of spike protein R-HSA-9683686 8.672215e-01 0.062 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 8.672215e-01 0.062 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.672215e-01 0.062 0 0
Tandem pore domain potassium channels R-HSA-1296346 8.672215e-01 0.062 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 8.715889e-01 0.060 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 8.715889e-01 0.060 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 8.715889e-01 0.060 0 0
Presynaptic function of Kainate receptors R-HSA-500657 8.715889e-01 0.060 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 8.715889e-01 0.060 0 0
Nephron development R-HSA-9831926 8.715889e-01 0.060 0 0
Suppression of phagosomal maturation R-HSA-9637687 8.728817e-01 0.059 0 0
Assembly of the pre-replicative complex R-HSA-68867 8.733463e-01 0.059 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 8.752881e-01 0.058 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 8.752881e-01 0.058 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 8.788539e-01 0.056 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.788539e-01 0.056 0 0
DNA Replication R-HSA-69306 8.841171e-01 0.053 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.850219e-01 0.053 0 0
Diseases of programmed cell death R-HSA-9645723 8.851175e-01 0.053 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 8.856039e-01 0.053 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.856039e-01 0.053 0 0
Cristae formation R-HSA-8949613 8.856039e-01 0.053 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 8.856039e-01 0.053 0 0
Maturation of hRSV A proteins R-HSA-9828806 8.856039e-01 0.053 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 8.863168e-01 0.052 0 0
FGFR2b ligand binding and activation R-HSA-190377 8.863297e-01 0.052 0 0
Conjugation of benzoate with glycine R-HSA-177135 8.863297e-01 0.052 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.863297e-01 0.052 0 0
vRNP Assembly R-HSA-192905 8.863297e-01 0.052 0 0
vRNA Synthesis R-HSA-192814 8.863297e-01 0.052 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 8.863297e-01 0.052 0 0
LGI-ADAM interactions R-HSA-5682910 8.863297e-01 0.052 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.863297e-01 0.052 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.863297e-01 0.052 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 8.863390e-01 0.052 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 8.863390e-01 0.052 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 8.863390e-01 0.052 0 0
Signaling by FGFR in disease R-HSA-1226099 8.878773e-01 0.052 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 8.910256e-01 0.050 0 0
Peroxisomal protein import R-HSA-9033241 8.937168e-01 0.049 0 0
DNA Replication Pre-Initiation R-HSA-69002 8.940801e-01 0.049 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 8.941048e-01 0.049 0 0
Kidney development R-HSA-9830369 8.942866e-01 0.049 0 0
PPARA activates gene expression R-HSA-1989781 8.950618e-01 0.048 0 0
Defective pyroptosis R-HSA-9710421 8.959328e-01 0.048 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.971706e-01 0.047 0 0
Pyrimidine salvage R-HSA-73614 8.971760e-01 0.047 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 8.995043e-01 0.046 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 8.995043e-01 0.046 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 8.995043e-01 0.046 0 0
Glycogen synthesis R-HSA-3322077 8.995043e-01 0.046 0 0
Triglyceride catabolism R-HSA-163560 8.999943e-01 0.046 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 9.001373e-01 0.046 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 9.017369e-01 0.045 0 0
Orc1 removal from chromatin R-HSA-68949 9.025677e-01 0.045 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 9.026891e-01 0.044 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 9.026891e-01 0.044 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 9.026891e-01 0.044 0 0
Plasmalogen biosynthesis R-HSA-75896 9.026891e-01 0.044 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 9.026891e-01 0.044 0 0
FMO oxidises nucleophiles R-HSA-217271 9.026891e-01 0.044 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 9.026891e-01 0.044 0 0
RMTs methylate histone arginines R-HSA-3214858 9.048362e-01 0.043 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.051651e-01 0.043 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.076831e-01 0.042 0 0
HCMV Infection R-HSA-9609646 9.086138e-01 0.042 0 0
Translation of Structural Proteins R-HSA-9694635 9.094673e-01 0.041 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.104419e-01 0.041 0 0
G-protein activation R-HSA-202040 9.112354e-01 0.040 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.112354e-01 0.040 0 0
Mitochondrial protein import R-HSA-1268020 9.162377e-01 0.038 0 0
Maple Syrup Urine Disease R-HSA-9865114 9.166948e-01 0.038 0 0
Scavenging by Class F Receptors R-HSA-3000484 9.166948e-01 0.038 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 9.166948e-01 0.038 0 0
VLDLR internalisation and degradation R-HSA-8866427 9.166948e-01 0.038 0 0
Conjugation of salicylate with glycine R-HSA-177128 9.166948e-01 0.038 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 9.166948e-01 0.038 0 0
Estrogen biosynthesis R-HSA-193144 9.166948e-01 0.038 0 0
SLC transporter disorders R-HSA-5619102 9.171349e-01 0.038 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.172071e-01 0.038 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.172071e-01 0.038 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.172071e-01 0.038 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 9.206661e-01 0.036 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.218161e-01 0.035 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 9.219458e-01 0.035 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.229462e-01 0.035 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.256047e-01 0.034 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.258261e-01 0.033 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.258261e-01 0.033 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.276709e-01 0.033 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.276709e-01 0.033 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 9.286854e-01 0.032 0 0
FGFR2c ligand binding and activation R-HSA-190375 9.286854e-01 0.032 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 9.286854e-01 0.032 0 0
FGFR1c ligand binding and activation R-HSA-190373 9.286854e-01 0.032 0 0
Processing of SMDT1 R-HSA-8949664 9.286854e-01 0.032 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 9.286854e-01 0.032 0 0
FGFR4 ligand binding and activation R-HSA-190322 9.286854e-01 0.032 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 9.286854e-01 0.032 0 0
Diseases of nucleotide metabolism R-HSA-9735804 9.286854e-01 0.032 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 9.286854e-01 0.032 0 0
Mtb iron assimilation by chelation R-HSA-1222449 9.286854e-01 0.032 0 0
FGFR3 mutant receptor activation R-HSA-2033514 9.286854e-01 0.032 0 0
rRNA modification in the mitochondrion R-HSA-6793080 9.286854e-01 0.032 0 0
FGFR2 alternative splicing R-HSA-6803529 9.309446e-01 0.031 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.309446e-01 0.031 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 9.309446e-01 0.031 0 0
Free fatty acid receptors R-HSA-444209 9.309446e-01 0.031 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.309446e-01 0.031 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.309446e-01 0.031 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.327279e-01 0.030 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.327279e-01 0.030 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 9.389507e-01 0.027 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 9.389507e-01 0.027 0 0
cGMP effects R-HSA-418457 9.389507e-01 0.027 0 0
FGFR3c ligand binding and activation R-HSA-190372 9.389507e-01 0.027 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 9.389507e-01 0.027 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 9.389507e-01 0.027 0 0
Hydrolysis of LPC R-HSA-1483115 9.389507e-01 0.027 0 0
N-glycan trimming and elongation in the cis-Golgi R-HSA-964739 9.389507e-01 0.027 0 0
Vitamin B2 (riboflavin) metabolism R-HSA-196843 9.389507e-01 0.027 0 0
Malate-aspartate shuttle R-HSA-9856872 9.389507e-01 0.027 0 0
Ciprofloxacin ADME R-HSA-9793528 9.389507e-01 0.027 0 0
Acyl chain remodeling of CL R-HSA-1482798 9.389507e-01 0.027 0 0
P2Y receptors R-HSA-417957 9.389507e-01 0.027 0 0
Zinc transporters R-HSA-435354 9.389507e-01 0.027 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.391711e-01 0.027 0 0
Maturation of spike protein R-HSA-9694548 9.392275e-01 0.027 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.400483e-01 0.027 0 0
Neurotransmitter release cycle R-HSA-112310 9.418228e-01 0.026 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.420442e-01 0.026 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.451501e-01 0.024 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.451501e-01 0.024 0 0
HIV Transcription Initiation R-HSA-167161 9.451501e-01 0.024 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.451501e-01 0.024 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.451501e-01 0.024 0 0
Complex III assembly R-HSA-9865881 9.464608e-01 0.024 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.464608e-01 0.024 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.477389e-01 0.023 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 9.477389e-01 0.023 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.477389e-01 0.023 0 0
Protein lipoylation R-HSA-9857492 9.477389e-01 0.023 0 0
Transport and metabolism of PAPS R-HSA-174362 9.477389e-01 0.023 0 0
FGFR3 ligand binding and activation R-HSA-190239 9.477389e-01 0.023 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.477389e-01 0.023 0 0
Other semaphorin interactions R-HSA-416700 9.477389e-01 0.023 0 0
tRNA Aminoacylation R-HSA-379724 9.515987e-01 0.022 0 0
G protein gated Potassium channels R-HSA-1296059 9.529128e-01 0.021 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.529128e-01 0.021 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.529128e-01 0.021 0 0
Hyaluronan degradation R-HSA-2160916 9.529128e-01 0.021 0 0
Innate Immune System R-HSA-168249 9.540170e-01 0.020 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.550588e-01 0.020 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.552624e-01 0.020 0 0
Activation of the phototransduction cascade R-HSA-2485179 9.552624e-01 0.020 0 0
Attachment and Entry R-HSA-9678110 9.552624e-01 0.020 0 0
Atorvastatin ADME R-HSA-9754706 9.552624e-01 0.020 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.554394e-01 0.020 0 0
Integrin cell surface interactions R-HSA-216083 9.555012e-01 0.020 0 0
tRNA processing R-HSA-72306 9.557818e-01 0.020 0 0
COPII-mediated vesicle transport R-HSA-204005 9.572505e-01 0.019 0 0
MET activates PTK2 signaling R-HSA-8874081 9.586172e-01 0.018 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.586172e-01 0.018 0 0
Abacavir ADME R-HSA-2161522 9.586172e-01 0.018 0 0
Surfactant metabolism R-HSA-5683826 9.598873e-01 0.018 0 0
Glycine degradation R-HSA-6783984 9.617032e-01 0.017 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.617032e-01 0.017 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.617032e-01 0.017 0 0
Heme assimilation R-HSA-9927020 9.617032e-01 0.017 0 0
Scavenging by Class B Receptors R-HSA-3000471 9.617032e-01 0.017 0 0
Vitamin B6 activation to pyridoxal phosphate R-HSA-964975 9.617032e-01 0.017 0 0
Phase 2 - plateau phase R-HSA-5576893 9.617032e-01 0.017 0 0
Galactose catabolism R-HSA-70370 9.617032e-01 0.017 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.617032e-01 0.017 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 9.623555e-01 0.017 0 0
Regulation of endogenous retroelements R-HSA-9842860 9.625388e-01 0.017 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.636555e-01 0.016 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.636555e-01 0.016 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.639207e-01 0.016 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.639207e-01 0.016 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.648862e-01 0.016 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.665185e-01 0.015 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.672171e-01 0.014 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.672171e-01 0.014 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.672171e-01 0.014 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.675744e-01 0.014 0 0
Prednisone ADME R-HSA-9757110 9.681012e-01 0.014 0 0
Elastic fibre formation R-HSA-1566948 9.702128e-01 0.013 0 0
Activated point mutants of FGFR2 R-HSA-2033519 9.719373e-01 0.012 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.719373e-01 0.012 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.719373e-01 0.012 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.719373e-01 0.012 0 0
DNA methylation R-HSA-5334118 9.720206e-01 0.012 0 0
DARPP-32 events R-HSA-180024 9.720206e-01 0.012 0 0
Glucagon-type ligand receptors R-HSA-420092 9.720206e-01 0.012 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.735189e-01 0.012 0 0
Stabilization of p53 R-HSA-69541 9.735189e-01 0.012 0 0
HCMV Late Events R-HSA-9610379 9.750617e-01 0.011 0 0
Neurotransmitter clearance R-HSA-112311 9.754728e-01 0.011 0 0
GPCR downstream signalling R-HSA-388396 9.757637e-01 0.011 0 0
Conjugation of carboxylic acids R-HSA-159424 9.759782e-01 0.011 0 0
Amino Acid conjugation R-HSA-156587 9.759782e-01 0.011 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.762808e-01 0.010 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.764746e-01 0.010 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.782145e-01 0.010 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.791146e-01 0.009 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.791146e-01 0.009 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.791146e-01 0.009 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.794374e-01 0.009 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.794374e-01 0.009 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.794374e-01 0.009 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.794374e-01 0.009 0 0
Negative regulation of MET activity R-HSA-6807004 9.794374e-01 0.009 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.798741e-01 0.009 0 0
Formation of the cornified envelope R-HSA-6809371 9.803576e-01 0.009 0 0
Protein localization R-HSA-9609507 9.809157e-01 0.008 0 0
The phototransduction cascade R-HSA-2514856 9.811977e-01 0.008 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.812163e-01 0.008 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.814705e-01 0.008 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.814705e-01 0.008 0 0
Translation of Structural Proteins R-HSA-9683701 9.814705e-01 0.008 0 0
Nucleotide salvage R-HSA-8956321 9.818555e-01 0.008 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.823986e-01 0.008 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 9.823986e-01 0.008 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.823986e-01 0.008 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.823986e-01 0.008 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.831743e-01 0.007 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.836489e-01 0.007 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.842717e-01 0.007 0 0
Amyloid fiber formation R-HSA-977225 9.843057e-01 0.007 0 0
ER-Phagosome pathway R-HSA-1236974 9.843302e-01 0.007 0 0
G alpha (s) signalling events R-HSA-418555 9.843854e-01 0.007 0 0
Eicosanoids R-HSA-211979 9.849335e-01 0.007 0 0
Miscellaneous substrates R-HSA-211958 9.849335e-01 0.007 0 0
Assembly Of The HIV Virion R-HSA-175474 9.849335e-01 0.007 0 0
Serine metabolism R-HSA-977347 9.849335e-01 0.007 0 0
Glutathione synthesis and recycling R-HSA-174403 9.849335e-01 0.007 0 0
Attachment and Entry R-HSA-9694614 9.849335e-01 0.007 0 0
Ribavirin ADME R-HSA-9755088 9.849335e-01 0.007 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.849528e-01 0.007 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.855943e-01 0.006 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.865519e-01 0.006 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.870611e-01 0.006 0 0
LDL clearance R-HSA-8964038 9.871035e-01 0.006 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.871084e-01 0.006 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.874044e-01 0.006 0 0
eNOS activation R-HSA-203615 9.874044e-01 0.006 0 0
Hyaluronan metabolism R-HSA-2142845 9.874044e-01 0.006 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.874044e-01 0.006 0 0
Cellular response to hypoxia R-HSA-1234174 9.880900e-01 0.005 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.885902e-01 0.005 0 0
Fatty acids R-HSA-211935 9.889611e-01 0.005 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.889611e-01 0.005 0 0
Biosynthesis of maresins R-HSA-9018682 9.889611e-01 0.005 0 0
Formation of the ureteric bud R-HSA-9830674 9.889611e-01 0.005 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.889611e-01 0.005 0 0
Regulation of Apoptosis R-HSA-169911 9.889921e-01 0.005 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.889921e-01 0.005 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.889921e-01 0.005 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.892778e-01 0.005 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.899073e-01 0.004 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.903838e-01 0.004 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.903838e-01 0.004 0 0
Synthesis of PA R-HSA-1483166 9.904344e-01 0.004 0 0
CYP2E1 reactions R-HSA-211999 9.905511e-01 0.004 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.905511e-01 0.004 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.914666e-01 0.004 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.916031e-01 0.004 0 0
Degradation of DVL R-HSA-4641258 9.916031e-01 0.004 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.916031e-01 0.004 0 0
Metabolism of folate and pterines R-HSA-196757 9.916031e-01 0.004 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.919123e-01 0.004 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.919123e-01 0.004 0 0
Laminin interactions R-HSA-3000157 9.919123e-01 0.004 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.919123e-01 0.004 0 0
Triglyceride metabolism R-HSA-8979227 9.923996e-01 0.003 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.926708e-01 0.003 0 0
Purine salvage R-HSA-74217 9.926708e-01 0.003 0 0
G alpha (i) signalling events R-HSA-418594 9.930444e-01 0.003 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.930774e-01 0.003 0 0
Urea cycle R-HSA-70635 9.930774e-01 0.003 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.934185e-01 0.003 0 0
Pentose phosphate pathway R-HSA-71336 9.936051e-01 0.003 0 0
Metabolism of cofactors R-HSA-8978934 9.937776e-01 0.003 0 0
Azathioprine ADME R-HSA-9748787 9.938531e-01 0.003 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.939740e-01 0.003 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.940747e-01 0.003 0 0
Insulin processing R-HSA-264876 9.940747e-01 0.003 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.944225e-01 0.002 0 0
Tryptophan catabolism R-HSA-71240 9.944225e-01 0.002 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.945764e-01 0.002 0 0
Insulin receptor recycling R-HSA-77387 9.949284e-01 0.002 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.951371e-01 0.002 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.952092e-01 0.002 0 0
ABC-family proteins mediated transport R-HSA-382556 9.954032e-01 0.002 0 0
Thyroxine biosynthesis R-HSA-209968 9.956591e-01 0.002 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.956591e-01 0.002 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.956591e-01 0.002 0 0
Nucleotide biosynthesis R-HSA-8956320 9.957836e-01 0.002 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.959123e-01 0.002 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.959123e-01 0.002 0 0
Signaling by GPCR R-HSA-372790 9.966550e-01 0.001 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.966565e-01 0.001 0 0
Paracetamol ADME R-HSA-9753281 9.967278e-01 0.001 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.967836e-01 0.001 0 0
Defensins R-HSA-1461973 9.967836e-01 0.001 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.968200e-01 0.001 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.968200e-01 0.001 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.970323e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.971511e-01 0.001 0 0
RSV-host interactions R-HSA-9833110 9.971957e-01 0.001 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.971994e-01 0.001 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.972497e-01 0.001 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.972783e-01 0.001 0 0
HS-GAG degradation R-HSA-2024096 9.972783e-01 0.001 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.975621e-01 0.001 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.975621e-01 0.001 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.975799e-01 0.001 0 0
Phospholipid metabolism R-HSA-1483257 9.976654e-01 0.001 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.976705e-01 0.001 0 0
Recycling of bile acids and salts R-HSA-159418 9.976705e-01 0.001 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.976705e-01 0.001 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.978786e-01 0.001 0 0
Infectious disease R-HSA-5663205 9.979628e-01 0.001 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.980063e-01 0.001 0 0
Heme degradation R-HSA-189483 9.980063e-01 0.001 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.980388e-01 0.001 0 0
Synthesis of PC R-HSA-1483191 9.981544e-01 0.001 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.982761e-01 0.001 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.982936e-01 0.001 0 0
RA biosynthesis pathway R-HSA-5365859 9.982936e-01 0.001 0 0
Metal ion SLC transporters R-HSA-425410 9.983949e-01 0.001 0 0
Collagen degradation R-HSA-1442490 9.984852e-01 0.001 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.985396e-01 0.001 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.985396e-01 0.001 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.985396e-01 0.001 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.985396e-01 0.001 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.987501e-01 0.001 0 0
Glycosphingolipid transport R-HSA-9845576 9.987501e-01 0.001 0 0
Mitochondrial protein degradation R-HSA-9837999 9.987846e-01 0.001 0 0
Iron uptake and transport R-HSA-917937 9.988738e-01 0.000 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.989303e-01 0.000 0 0
NCAM1 interactions R-HSA-419037 9.989303e-01 0.000 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.989303e-01 0.000 0 0
Collagen chain trimerization R-HSA-8948216 9.989303e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.989457e-01 0.000 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.989457e-01 0.000 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.990845e-01 0.000 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.992165e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.993076e-01 0.000 0 0
Glucuronidation R-HSA-156588 9.993090e-01 0.000 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.993295e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.994044e-01 0.000 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.994262e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.994911e-01 0.000 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.995089e-01 0.000 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.995089e-01 0.000 0 0
Heme biosynthesis R-HSA-189451 9.995089e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.995480e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.995917e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.995917e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.996425e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.996598e-01 0.000 0 0
Translation R-HSA-72766 9.996791e-01 0.000 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.996922e-01 0.000 0 0
Methylation R-HSA-156581 9.996922e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.997049e-01 0.000 0 0
Disease R-HSA-1643685 9.997155e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.997261e-01 0.000 0 0
Somitogenesis R-HSA-9824272 9.997366e-01 0.000 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.997366e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.997441e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.997603e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.997780e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.998071e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.998077e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.998083e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.998333e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.998333e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.998397e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.998485e-01 0.000 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.998588e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.998588e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.998628e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.998791e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.998916e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.998930e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.998966e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999011e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999287e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999296e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999328e-01 0.000 0 0
Neddylation R-HSA-8951664 9.999388e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.999390e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999460e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.999526e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999526e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.999526e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999543e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.999605e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999634e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.999703e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.999703e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.999746e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999779e-01 0.000 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.999819e-01 0.000 0 0
Collagen formation R-HSA-1474290 9.999862e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999883e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999915e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.999915e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999925e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.999927e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999944e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.999947e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999949e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.999954e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.999954e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999961e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999965e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999982e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.999985e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999986e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999987e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999988e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999990e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999990e-01 0.000 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.999993e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999995e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999997e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999997e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999997e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999998e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999999e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999999e-01 0.000 1 0
Scavenging of heme from plasma R-HSA-2168880 9.999999e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 3.663736e-15 14.436 0 0
Cell Cycle, Mitotic R-HSA-69278 1.587619e-12 11.799 0 0
M Phase R-HSA-68886 1.641423e-10 9.785 0 0
Cellular response to heat stress R-HSA-3371556 5.110221e-10 9.292 0 0
Mitotic Prometaphase R-HSA-68877 1.039968e-09 8.983 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.701965e-08 7.769 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 3.655108e-08 7.437 0 0
HSF1-dependent transactivation R-HSA-3371571 4.523108e-08 7.345 0 0
Cellular responses to stimuli R-HSA-8953897 7.545480e-08 7.122 0 0
Mitotic Anaphase R-HSA-68882 9.746464e-08 7.011 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.117489e-07 6.952 0 0
Chromatin organization R-HSA-4839726 1.465830e-07 6.834 0 0
Cell Cycle Checkpoints R-HSA-69620 2.101395e-07 6.677 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.249189e-07 6.648 0 0
Separation of Sister Chromatids R-HSA-2467813 4.067816e-07 6.391 0 0
Chromatin modifying enzymes R-HSA-3247509 4.666796e-07 6.331 0 0
Attenuation phase R-HSA-3371568 9.017619e-07 6.045 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.175716e-06 5.930 0 0
Cellular responses to stress R-HSA-2262752 1.323891e-06 5.878 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.551138e-06 5.593 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 7.047443e-06 5.152 0 0
Amplification of signal from the kinetochores R-HSA-141424 7.047443e-06 5.152 0 0
Apoptotic execution phase R-HSA-75153 6.908897e-06 5.161 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 8.458570e-06 5.073 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 8.991812e-06 5.046 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.198458e-05 4.921 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.193158e-05 4.923 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.391918e-05 4.856 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.385283e-05 4.858 0 0
HSF1 activation R-HSA-3371511 1.458685e-05 4.836 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.457823e-05 4.836 0 0
Regulation of TP53 Activity R-HSA-5633007 2.961320e-05 4.529 0 0
Nuclear Envelope Breakdown R-HSA-2980766 3.020135e-05 4.520 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 3.965962e-05 4.402 0 0
Aggrephagy R-HSA-9646399 4.352970e-05 4.361 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.502054e-05 4.347 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 4.612149e-05 4.336 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 6.777345e-05 4.169 0 0
Cell-extracellular matrix interactions R-HSA-446353 8.622940e-05 4.064 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.120730e-04 3.950 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.424820e-04 3.846 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.424820e-04 3.846 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.424820e-04 3.846 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.838651e-04 3.736 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.953221e-04 3.709 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.136417e-04 3.670 0 0
Mitotic Prophase R-HSA-68875 2.416941e-04 3.617 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 2.760113e-04 3.559 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.746942e-04 3.561 0 0
Recycling pathway of L1 R-HSA-437239 2.733121e-04 3.563 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.819144e-04 3.550 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.344510e-04 3.476 0 0
Nuclear import of Rev protein R-HSA-180746 3.501423e-04 3.456 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.500088e-04 3.456 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 3.534946e-04 3.452 0 0
Metabolism of non-coding RNA R-HSA-194441 3.556705e-04 3.449 0 0
snRNP Assembly R-HSA-191859 3.556705e-04 3.449 0 0
Transport of connexons to the plasma membrane R-HSA-190872 3.892891e-04 3.410 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 4.310369e-04 3.365 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 4.310369e-04 3.365 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 4.426445e-04 3.354 0 0
Macroautophagy R-HSA-1632852 4.499058e-04 3.347 0 0
Cellular Senescence R-HSA-2559583 5.625166e-04 3.250 0 0
Autophagy R-HSA-9612973 6.267097e-04 3.203 0 0
L1CAM interactions R-HSA-373760 6.592934e-04 3.181 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 6.689586e-04 3.175 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 6.963505e-04 3.157 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 7.764574e-04 3.110 0 0
Signaling by ALK in cancer R-HSA-9700206 7.764574e-04 3.110 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 8.233229e-04 3.084 0 0
Striated Muscle Contraction R-HSA-390522 8.737213e-04 3.059 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 8.737213e-04 3.059 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.045089e-03 2.981 0 0
Selective autophagy R-HSA-9663891 1.045089e-03 2.981 0 0
HATs acetylate histones R-HSA-3214847 1.160988e-03 2.935 0 0
Metabolism of RNA R-HSA-8953854 1.283155e-03 2.892 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.378133e-03 2.861 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.550376e-03 2.810 0 0
PKR-mediated signaling R-HSA-9833482 1.558877e-03 2.807 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 1.685901e-03 2.773 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.714911e-03 2.766 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.761207e-03 2.754 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.779590e-03 2.750 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.839270e-03 2.735 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.908121e-03 2.719 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.041614e-03 2.690 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 2.166940e-03 2.664 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 2.449991e-03 2.611 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.670434e-03 2.573 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.670434e-03 2.573 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.670434e-03 2.573 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.670434e-03 2.573 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.670434e-03 2.573 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.655674e-03 2.576 0 0
mRNA Splicing R-HSA-72172 2.638777e-03 2.579 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.819891e-03 2.550 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 3.041379e-03 2.517 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.734885e-03 2.428 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.745006e-03 2.427 0 0
Chaperonin-mediated protein folding R-HSA-390466 4.204383e-03 2.376 0 0
Post NMDA receptor activation events R-HSA-438064 4.204383e-03 2.376 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 4.170346e-03 2.380 0 0
Signaling by Hippo R-HSA-2028269 4.244822e-03 2.372 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 4.140157e-03 2.383 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 4.369143e-03 2.360 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 4.140157e-03 2.383 0 0
Gene expression (Transcription) R-HSA-74160 4.870906e-03 2.312 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 5.215971e-03 2.283 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 5.262099e-03 2.279 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 5.262099e-03 2.279 0 0
DNA Double-Strand Break Repair R-HSA-5693532 5.323844e-03 2.274 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 5.433056e-03 2.265 0 0
AURKA Activation by TPX2 R-HSA-8854518 5.930514e-03 2.227 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 5.971382e-03 2.224 0 0
Kinesins R-HSA-983189 6.001697e-03 2.222 0 0
Oncogenic MAPK signaling R-HSA-6802957 6.118331e-03 2.213 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 6.440628e-03 2.191 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 6.549868e-03 2.184 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 6.776101e-03 2.169 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 6.864028e-03 2.163 0 0
Gap junction trafficking and regulation R-HSA-157858 6.864028e-03 2.163 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 7.597956e-03 2.119 0 0
G2/M DNA damage checkpoint R-HSA-69473 7.372484e-03 2.132 0 0
MITF-M-dependent gene expression R-HSA-9856651 7.257294e-03 2.139 0 0
Gap junction trafficking R-HSA-190828 7.818014e-03 2.107 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 7.824592e-03 2.107 0 0
Response of endothelial cells to shear stress R-HSA-9860931 7.959360e-03 2.099 0 0
Protein folding R-HSA-391251 8.047053e-03 2.094 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 8.107574e-03 2.091 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 8.107574e-03 2.091 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 8.923315e-03 2.049 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 8.923315e-03 2.049 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 8.818298e-03 2.055 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 8.477393e-03 2.072 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 8.477393e-03 2.072 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 8.807721e-03 2.055 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 8.807721e-03 2.055 0 0
Interferon Signaling R-HSA-913531 8.970198e-03 2.047 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 9.053083e-03 2.043 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 9.393726e-03 2.027 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 9.393726e-03 2.027 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.087292e-02 1.964 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.095486e-02 1.960 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.025835e-02 1.989 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.025835e-02 1.989 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 1.025835e-02 1.989 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.043598e-02 1.981 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.043598e-02 1.981 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.043598e-02 1.981 0 0
Signaling by RAS mutants R-HSA-6802949 1.043598e-02 1.981 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.078576e-02 1.967 0 0
HDMs demethylate histones R-HSA-3214842 1.025835e-02 1.989 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.127849e-02 1.948 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.127849e-02 1.948 0 0
Signal Transduction R-HSA-162582 1.136117e-02 1.945 0 0
CaM pathway R-HSA-111997 1.172990e-02 1.931 0 0
Calmodulin induced events R-HSA-111933 1.172990e-02 1.931 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.196613e-02 1.922 0 0
ALK mutants bind TKIs R-HSA-9700645 1.288781e-02 1.890 0 0
Axon guidance R-HSA-422475 1.310926e-02 1.882 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.369024e-02 1.864 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.481072e-02 1.829 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.555744e-02 1.808 0 0
G2/M Checkpoints R-HSA-69481 1.421797e-02 1.847 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.555744e-02 1.808 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.424672e-02 1.846 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.585671e-02 1.800 0 0
Death Receptor Signaling R-HSA-73887 1.640191e-02 1.785 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.643575e-02 1.784 0 0
tRNA processing in the nucleus R-HSA-6784531 1.643575e-02 1.784 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.715882e-02 1.766 0 0
Deubiquitination R-HSA-5688426 1.751046e-02 1.757 0 0
2-LTR circle formation R-HSA-164843 1.755758e-02 1.756 0 0
Host Interactions of HIV factors R-HSA-162909 1.787984e-02 1.748 0 0
Membrane Trafficking R-HSA-199991 1.809444e-02 1.742 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.816282e-02 1.741 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.828796e-02 1.738 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.828809e-02 1.738 0 0
Signaling by NOTCH1 R-HSA-1980143 1.835937e-02 1.736 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 2.012851e-02 1.696 0 0
Homology Directed Repair R-HSA-5693538 1.925807e-02 1.715 0 0
DAG and IP3 signaling R-HSA-1489509 2.058025e-02 1.687 0 0
HIV Life Cycle R-HSA-162587 2.011460e-02 1.696 0 0
G2/M Transition R-HSA-69275 2.153409e-02 1.667 0 0
Gap junction assembly R-HSA-190861 2.107563e-02 1.676 0 0
Nervous system development R-HSA-9675108 2.152733e-02 1.667 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.215351e-02 1.655 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.226642e-02 1.652 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.226642e-02 1.652 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.226642e-02 1.652 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.226642e-02 1.652 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.226642e-02 1.652 0 0
mRNA 3'-end processing R-HSA-72187 2.247154e-02 1.648 0 0
Neurexins and neuroligins R-HSA-6794361 2.247154e-02 1.648 0 0
ChREBP activates metabolic gene expression R-HSA-163765 2.322750e-02 1.634 0 0
Diseases of DNA repair R-HSA-9675135 2.331517e-02 1.632 0 0
COPI-mediated anterograde transport R-HSA-6807878 2.381382e-02 1.623 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.396530e-02 1.620 0 0
Activation of the pre-replicative complex R-HSA-68962 2.420613e-02 1.616 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.427038e-02 1.615 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.431433e-02 1.614 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.856923e-02 1.544 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.620005e-02 1.582 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.588311e-02 1.587 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.856923e-02 1.544 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.765342e-02 1.558 0 0
ER to Golgi Anterograde Transport R-HSA-199977 2.684636e-02 1.571 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.789658e-02 1.554 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.615009e-02 1.583 0 0
Phosphorylation of the APC/C R-HSA-176412 2.858100e-02 1.544 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.858100e-02 1.544 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.948523e-02 1.530 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.964552e-02 1.528 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.964552e-02 1.528 0 0
Integration of provirus R-HSA-162592 2.996225e-02 1.523 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.006949e-02 1.522 0 0
Inositol phosphate metabolism R-HSA-1483249 3.040938e-02 1.517 0 0
Ca-dependent events R-HSA-111996 3.082818e-02 1.511 0 0
Early Phase of HIV Life Cycle R-HSA-162594 3.131491e-02 1.504 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 3.131491e-02 1.504 0 0
Centrosome maturation R-HSA-380287 3.161148e-02 1.500 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 3.203068e-02 1.494 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 3.239845e-02 1.489 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 3.280178e-02 1.484 0 0
Formation of annular gap junctions R-HSA-196025 3.834802e-02 1.416 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 3.781101e-02 1.422 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.712208e-02 1.430 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 3.492013e-02 1.457 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.519160e-02 1.454 0 0
Epigenetic regulation of gene expression R-HSA-212165 3.574428e-02 1.447 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 3.767000e-02 1.424 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 3.721664e-02 1.429 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.721664e-02 1.429 0 0
Semaphorin interactions R-HSA-373755 3.619473e-02 1.441 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 3.714890e-02 1.430 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.721664e-02 1.429 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.712208e-02 1.430 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.834802e-02 1.416 0 0
NRAGE signals death through JNK R-HSA-193648 3.487709e-02 1.457 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.841006e-02 1.416 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 4.086629e-02 1.389 0 0
Signaling by ALK R-HSA-201556 4.086629e-02 1.389 0 0
Cilium Assembly R-HSA-5617833 4.114180e-02 1.386 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 4.149544e-02 1.382 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 4.209988e-02 1.376 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 4.264489e-02 1.370 0 0
Organelle biogenesis and maintenance R-HSA-1852241 4.353611e-02 1.361 0 0
mTORC1-mediated signalling R-HSA-166208 4.359591e-02 1.361 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 4.372307e-02 1.359 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 4.442677e-02 1.352 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 4.567225e-02 1.340 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.652857e-02 1.332 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.680337e-02 1.330 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 4.695164e-02 1.328 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 4.814879e-02 1.317 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.842033e-02 1.315 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 4.866605e-02 1.313 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 4.873254e-02 1.312 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.981408e-02 1.303 0 0
Gap junction degradation R-HSA-190873 4.981408e-02 1.303 0 0
Unwinding of DNA R-HSA-176974 4.981408e-02 1.303 0 0
Calcineurin activates NFAT R-HSA-2025928 4.981408e-02 1.303 0 0
Polo-like kinase mediated events R-HSA-156711 5.014422e-02 1.300 0 0
Chaperone Mediated Autophagy R-HSA-9613829 5.014422e-02 1.300 0 0
Smooth Muscle Contraction R-HSA-445355 5.034217e-02 1.298 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 5.075587e-02 1.295 0 0
Regulation of PTEN gene transcription R-HSA-8943724 5.155069e-02 1.288 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 5.155069e-02 1.288 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 5.696717e-02 1.244 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 5.906862e-02 1.229 0 0
G1/S-Specific Transcription R-HSA-69205 6.101819e-02 1.215 0 0
Translation initiation complex formation R-HSA-72649 5.545349e-02 1.256 0 0
HCMV Early Events R-HSA-9609690 5.592013e-02 1.252 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 6.126443e-02 1.213 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 6.090236e-02 1.215 0 0
Heme signaling R-HSA-9707616 6.165242e-02 1.210 0 0
Signaling by NOTCH3 R-HSA-9012852 6.090236e-02 1.215 0 0
HIV Infection R-HSA-162906 5.981790e-02 1.223 0 0
Regulation of KIT signaling R-HSA-1433559 5.696717e-02 1.244 0 0
Programmed Cell Death R-HSA-5357801 6.266212e-02 1.203 0 0
SARS-CoV-2-host interactions R-HSA-9705683 6.255464e-02 1.204 0 0
Glycolysis R-HSA-70171 5.547853e-02 1.256 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 6.295642e-02 1.201 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 6.295642e-02 1.201 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 6.295642e-02 1.201 0 0
MTOR signalling R-HSA-165159 6.383986e-02 1.195 0 0
EGFR downregulation R-HSA-182971 6.436876e-02 1.191 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 6.449193e-02 1.190 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.449193e-02 1.190 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 6.449193e-02 1.190 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 6.449193e-02 1.190 0 0
Apoptosis R-HSA-109581 6.457996e-02 1.190 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 6.632421e-02 1.178 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 6.643099e-02 1.178 0 0
Signaling by EGFR R-HSA-177929 6.669473e-02 1.176 0 0
S Phase R-HSA-69242 6.831814e-02 1.165 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 6.935200e-02 1.159 0 0
Protein-protein interactions at synapses R-HSA-6794362 7.133564e-02 1.147 0 0
MHC class II antigen presentation R-HSA-2132295 7.186682e-02 1.143 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 7.215730e-02 1.142 0 0
G alpha (12/13) signalling events R-HSA-416482 7.215730e-02 1.142 0 0
Opioid Signalling R-HSA-111885 7.247115e-02 1.140 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 7.273589e-02 1.138 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 7.283541e-02 1.138 0 0
Influenza Infection R-HSA-168255 7.429836e-02 1.129 0 0
Myogenesis R-HSA-525793 7.647050e-02 1.117 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 7.687901e-02 1.114 0 0
Regulation of TP53 Expression R-HSA-6804754 7.687901e-02 1.114 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 7.687901e-02 1.114 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 7.687901e-02 1.114 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 7.687901e-02 1.114 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 7.687901e-02 1.114 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 7.687901e-02 1.114 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 7.687901e-02 1.114 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 7.687901e-02 1.114 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 7.687901e-02 1.114 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 7.687901e-02 1.114 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 7.687901e-02 1.114 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 7.932812e-02 1.101 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 8.469990e-02 1.072 0 0
Autointegration results in viral DNA circles R-HSA-177539 8.469990e-02 1.072 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 9.407568e-02 1.027 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 8.077265e-02 1.093 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.437822e-02 1.025 0 0
Nucleosome assembly R-HSA-774815 8.564052e-02 1.067 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 8.564052e-02 1.067 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 9.337869e-02 1.030 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 9.115049e-02 1.040 0 0
DNA Double Strand Break Response R-HSA-5693606 9.240269e-02 1.034 0 0
Adipogenesis R-HSA-9843745 8.284692e-02 1.082 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 8.123656e-02 1.090 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 9.240269e-02 1.034 0 0
RAF activation R-HSA-5673000 1.004814e-01 0.998 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 9.337869e-02 1.030 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 9.337869e-02 1.030 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 9.337869e-02 1.030 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 9.337869e-02 1.030 0 0
RNA Polymerase II Transcription R-HSA-73857 8.318956e-02 1.080 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 8.469990e-02 1.072 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 9.115049e-02 1.040 0 0
Diseases of programmed cell death R-HSA-9645723 9.386078e-02 1.028 0 0
Intracellular signaling by second messengers R-HSA-9006925 9.762719e-02 1.010 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 8.646683e-02 1.063 0 0
Cell-Cell communication R-HSA-1500931 9.112906e-02 1.040 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 8.077265e-02 1.093 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 8.564052e-02 1.067 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 9.337869e-02 1.030 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 8.469990e-02 1.072 0 0
PLC beta mediated events R-HSA-112043 1.009381e-01 0.996 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.020339e-01 0.991 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 1.024027e-01 0.990 0 0
Notch-HLH transcription pathway R-HSA-350054 1.035829e-01 0.985 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.035829e-01 0.985 0 0
Interleukin-12 signaling R-HSA-9020591 1.048182e-01 0.980 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 1.072308e-01 0.970 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 1.072308e-01 0.970 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.072308e-01 0.970 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.072308e-01 0.970 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.072308e-01 0.970 0 0
SOS-mediated signalling R-HSA-112412 1.072308e-01 0.970 0 0
Regulation of PTEN localization R-HSA-8948747 1.072308e-01 0.970 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.075378e-01 0.968 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.075378e-01 0.968 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.075378e-01 0.968 0 0
DARPP-32 events R-HSA-180024 1.085664e-01 0.964 0 0
Uptake and function of anthrax toxins R-HSA-5210891 1.090711e-01 0.962 0 0
HDACs deacetylate histones R-HSA-3214815 1.104028e-01 0.957 0 0
Oncogene Induced Senescence R-HSA-2559585 1.109829e-01 0.955 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.109829e-01 0.955 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.112265e-01 0.954 0 0
MET interacts with TNS proteins R-HSA-8875513 1.117291e-01 0.952 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 1.118935e-01 0.951 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.118935e-01 0.951 0 0
Repression of WNT target genes R-HSA-4641265 1.118935e-01 0.951 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.118935e-01 0.951 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.124942e-01 0.949 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.124942e-01 0.949 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.147137e-01 0.940 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.177576e-01 0.929 0 0
Muscle contraction R-HSA-397014 1.177576e-01 0.929 0 0
Regulation of gap junction activity R-HSA-191650 1.497613e-01 0.825 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 1.497613e-01 0.825 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 1.497613e-01 0.825 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 1.497613e-01 0.825 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 1.497613e-01 0.825 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 1.581029e-01 0.801 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.310783e-01 0.882 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.310783e-01 0.882 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.310783e-01 0.882 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.515081e-01 0.820 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.336898e-01 0.874 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.192403e-01 0.924 0 0
IRE1alpha activates chaperones R-HSA-381070 1.204148e-01 0.919 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 1.317003e-01 0.880 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.481196e-01 0.829 0 0
DNA strand elongation R-HSA-69190 1.467445e-01 0.833 0 0
G0 and Early G1 R-HSA-1538133 1.467445e-01 0.833 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.248013e-01 0.904 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.310783e-01 0.882 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.535409e-01 0.814 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 1.317983e-01 0.880 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 1.310783e-01 0.882 0 0
Ephrin signaling R-HSA-3928664 1.248013e-01 0.904 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 1.497613e-01 0.825 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 1.581029e-01 0.801 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.398930e-01 0.854 0 0
G-protein mediated events R-HSA-112040 1.536332e-01 0.814 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 1.317983e-01 0.880 0 0
Trafficking of AMPA receptors R-HSA-399719 1.333765e-01 0.875 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.554055e-01 0.809 0 0
Sensory perception of sour taste R-HSA-9729555 1.497613e-01 0.825 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 1.515081e-01 0.820 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.481196e-01 0.829 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.285813e-01 0.891 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.248013e-01 0.904 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.309208e-01 0.883 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.309208e-01 0.883 0 0
Neurodegenerative Diseases R-HSA-8863678 1.309208e-01 0.883 0 0
MTF1 activates gene expression R-HSA-5660489 1.497613e-01 0.825 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.497613e-01 0.825 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.581029e-01 0.801 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.581029e-01 0.801 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.310783e-01 0.882 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.248013e-01 0.904 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.248013e-01 0.904 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.336898e-01 0.874 0 0
Signaling by VEGF R-HSA-194138 1.268360e-01 0.897 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.467445e-01 0.833 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.581029e-01 0.801 0 0
Signaling by SCF-KIT R-HSA-1433557 1.326849e-01 0.877 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 1.497613e-01 0.825 0 0
The NLRP3 inflammasome R-HSA-844456 1.415095e-01 0.849 0 0
Interleukin-12 family signaling R-HSA-447115 1.396642e-01 0.855 0 0
Gene Silencing by RNA R-HSA-211000 1.407404e-01 0.852 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.192403e-01 0.924 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 1.582196e-01 0.801 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.591280e-01 0.798 0 0
Negative regulation of MET activity R-HSA-6807004 1.591280e-01 0.798 0 0
Nuclear RNA decay R-HSA-9930044 1.607179e-01 0.794 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.607179e-01 0.794 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.607179e-01 0.794 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.613208e-01 0.792 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.630650e-01 0.788 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.635908e-01 0.786 0 0
Cell junction organization R-HSA-446728 1.652913e-01 0.782 0 0
DNA Repair R-HSA-73894 1.667125e-01 0.778 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.675860e-01 0.776 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 1.676743e-01 0.776 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.697838e-01 0.770 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.717561e-01 0.765 0 0
Glucose metabolism R-HSA-70326 1.729075e-01 0.762 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.730514e-01 0.762 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.730514e-01 0.762 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.730514e-01 0.762 0 0
p75NTR signals via NF-kB R-HSA-193639 1.730514e-01 0.762 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.752652e-01 0.756 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 1.752652e-01 0.756 0 0
DNA Replication R-HSA-69306 1.764024e-01 0.753 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.775831e-01 0.751 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 1.800931e-01 0.745 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.035169e-01 0.691 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.035169e-01 0.691 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.035169e-01 0.691 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.035169e-01 0.691 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.035169e-01 0.691 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 2.035169e-01 0.691 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.035169e-01 0.691 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.035169e-01 0.691 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 2.891790e-01 0.539 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 2.891790e-01 0.539 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 2.891790e-01 0.539 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 2.891790e-01 0.539 0 0
Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) R-HSA-5619048 2.891790e-01 0.539 0 0
Defective SLC34A2 causes PALM R-HSA-5687583 2.891790e-01 0.539 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.891790e-01 0.539 0 0
IKBKB deficiency causes SCID R-HSA-5602636 2.891790e-01 0.539 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 2.891790e-01 0.539 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 2.891790e-01 0.539 0 0
Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) R-HSA-5619045 2.891790e-01 0.539 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 1.898889e-01 0.722 0 0
IRS activation R-HSA-74713 1.898889e-01 0.722 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.898889e-01 0.722 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.312222e-01 0.636 0 0
Cam-PDE 1 activation R-HSA-111957 2.312222e-01 0.636 0 0
Phosphorylation of Emi1 R-HSA-176417 2.312222e-01 0.636 0 0
Signaling by MAPK mutants R-HSA-9652817 2.312222e-01 0.636 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.656326e-01 0.437 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 3.656326e-01 0.437 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 3.656326e-01 0.437 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 3.656326e-01 0.437 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.656326e-01 0.437 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.656326e-01 0.437 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.858428e-01 0.731 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.730382e-01 0.564 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 2.730382e-01 0.564 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 2.730382e-01 0.564 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.147231e-01 0.668 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 2.147231e-01 0.668 0 0
Regulation of BACH1 activity R-HSA-9708530 1.955700e-01 0.709 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 3.147555e-01 0.502 0 0
PTK6 Expression R-HSA-8849473 3.147555e-01 0.502 0 0
Disinhibition of SNARE formation R-HSA-114516 3.147555e-01 0.502 0 0
Recycling of eIF2:GDP R-HSA-72731 3.147555e-01 0.502 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.147555e-01 0.502 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 4.338671e-01 0.363 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 4.338671e-01 0.363 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 4.338671e-01 0.363 0 0
Defective DPM1 causes DPM1-CDG R-HSA-4717374 4.338671e-01 0.363 0 0
Classical Kir channels R-HSA-1296053 4.338671e-01 0.363 0 0
Defective DPM2 causes DPM2-CDG R-HSA-4719377 4.338671e-01 0.363 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.338671e-01 0.363 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.338671e-01 0.363 0 0
Defective DPM3 causes DPM3-CDG R-HSA-4719360 4.338671e-01 0.363 0 0
MET activates PTPN11 R-HSA-8865999 4.338671e-01 0.363 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 2.189230e-01 0.660 0 0
MET activates RAS signaling R-HSA-8851805 2.747920e-01 0.561 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.967956e-01 0.706 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.967956e-01 0.706 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.967956e-01 0.706 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.429686e-01 0.614 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.429686e-01 0.614 0 0
Type I hemidesmosome assembly R-HSA-446107 3.559120e-01 0.449 0 0
Regulation by c-FLIP R-HSA-3371378 3.559120e-01 0.449 0 0
Dimerization of procaspase-8 R-HSA-69416 3.559120e-01 0.449 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.559120e-01 0.449 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.559120e-01 0.449 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.675668e-01 0.573 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.675668e-01 0.573 0 0
PKA activation R-HSA-163615 2.675668e-01 0.573 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 2.675668e-01 0.573 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.118695e-01 0.674 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 2.298277e-01 0.639 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 2.298277e-01 0.639 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.581401e-01 0.588 0 0
Deadenylation of mRNA R-HSA-429947 2.581401e-01 0.588 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.961459e-01 0.402 0 0
ARMS-mediated activation R-HSA-170984 3.961459e-01 0.402 0 0
CASP8 activity is inhibited R-HSA-5218900 3.961459e-01 0.402 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.947657e-01 0.306 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.947657e-01 0.306 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.947657e-01 0.306 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.947657e-01 0.306 0 0
MAP2K and MAPK activation R-HSA-5674135 1.995443e-01 0.700 0 0
Long-term potentiation R-HSA-9620244 2.795375e-01 0.554 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.178815e-01 0.498 0 0
Erythropoietin activates RAS R-HSA-9027284 3.669941e-01 0.435 0 0
Processive synthesis on the lagging strand R-HSA-69183 3.669941e-01 0.435 0 0
G beta:gamma signalling through BTK R-HSA-8964315 3.669941e-01 0.435 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.987424e-01 0.702 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.862203e-01 0.543 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 3.433422e-01 0.464 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 3.433422e-01 0.464 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 4.351797e-01 0.361 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.351797e-01 0.361 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 4.351797e-01 0.361 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.232429e-01 0.490 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 3.056587e-01 0.515 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 2.899745e-01 0.538 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 2.899745e-01 0.538 0 0
Meiotic synapsis R-HSA-1221632 2.628373e-01 0.580 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 2.628373e-01 0.580 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 3.253188e-01 0.488 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 2.927571e-01 0.533 0 0
Signaling by Erythropoietin R-HSA-9006335 3.676165e-01 0.435 0 0
Late endosomal microautophagy R-HSA-9615710 3.676165e-01 0.435 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 4.275126e-01 0.369 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 4.275126e-01 0.369 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 4.275126e-01 0.369 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.788449e-01 0.555 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.902384e-01 0.721 0 0
Orc1 removal from chromatin R-HSA-68949 3.753386e-01 0.426 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 3.753386e-01 0.426 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.445731e-01 0.352 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 4.445731e-01 0.352 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 5.088768e-01 0.293 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.088768e-01 0.293 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 5.088768e-01 0.293 0 0
Signaling by GSK3beta mutants R-HSA-5339716 5.088768e-01 0.293 0 0
Formation of a pool of free 40S subunits R-HSA-72689 3.244166e-01 0.489 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.923035e-01 0.406 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.858538e-01 0.313 0 0
PKA activation in glucagon signalling R-HSA-164378 4.858538e-01 0.313 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 4.858538e-01 0.313 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.409373e-01 0.467 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.409373e-01 0.467 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 4.692474e-01 0.329 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 4.692474e-01 0.329 0 0
G protein gated Potassium channels R-HSA-1296059 4.692474e-01 0.329 0 0
Neutrophil degranulation R-HSA-6798695 1.979530e-01 0.703 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 4.350086e-01 0.362 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.977483e-01 0.400 0 0
Signaling by EGFR in Cancer R-HSA-1643713 4.935073e-01 0.307 0 0
Regulation of signaling by CBL R-HSA-912631 5.139308e-01 0.289 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 4.792657e-01 0.319 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 4.861435e-01 0.313 0 0
Defective pyroptosis R-HSA-9710421 5.222517e-01 0.282 0 0
Telomere Extension By Telomerase R-HSA-171319 5.405308e-01 0.267 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 5.125919e-01 0.290 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 5.405712e-01 0.267 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.226889e-01 0.652 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.043260e-01 0.690 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.898606e-01 0.409 0 0
Co-inhibition by PD-1 R-HSA-389948 3.635653e-01 0.439 0 0
Specification of the neural plate border R-HSA-9834899 2.925815e-01 0.534 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.953149e-01 0.709 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.953149e-01 0.709 0 0
Chromosome Maintenance R-HSA-73886 2.058964e-01 0.686 0 0
RNA Polymerase III Transcription R-HSA-74158 5.405712e-01 0.267 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 5.033851e-01 0.298 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 4.570155e-01 0.340 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 4.445731e-01 0.352 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 4.752982e-01 0.323 0 0
Prolonged ERK activation events R-HSA-169893 1.955700e-01 0.709 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.935073e-01 0.307 0 0
Synthesis of DNA R-HSA-69239 2.047891e-01 0.689 0 0
ESR-mediated signaling R-HSA-8939211 2.101005e-01 0.678 0 0
Meiosis R-HSA-1500620 2.659521e-01 0.575 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 4.259835e-01 0.371 0 0
G-protein beta:gamma signalling R-HSA-397795 2.862203e-01 0.543 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.088768e-01 0.293 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.712095e-01 0.327 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.712095e-01 0.327 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 3.076973e-01 0.512 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 2.298277e-01 0.639 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 4.570155e-01 0.340 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 4.023792e-01 0.395 0 0
Frs2-mediated activation R-HSA-170968 3.054699e-01 0.515 0 0
Pexophagy R-HSA-9664873 4.351797e-01 0.361 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 5.172873e-01 0.286 0 0
Josephin domain DUBs R-HSA-5689877 1.858428e-01 0.731 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.858428e-01 0.731 0 0
CD28 dependent Vav1 pathway R-HSA-389359 3.054699e-01 0.515 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 4.445731e-01 0.352 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.926069e-01 0.406 0 0
Clathrin-mediated endocytosis R-HSA-8856828 3.770662e-01 0.424 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.834313e-01 0.737 0 0
G1/S Transition R-HSA-69206 1.817898e-01 0.740 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 2.925815e-01 0.534 0 0
UCH proteinases R-HSA-5689603 3.615128e-01 0.442 0 0
Germ layer formation at gastrulation R-HSA-9754189 5.139308e-01 0.289 0 0
Regulation of CDH11 function R-HSA-9762292 1.858428e-01 0.731 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 2.444612e-01 0.612 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.559120e-01 0.449 0 0
PI3K/AKT activation R-HSA-198203 4.351797e-01 0.361 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 4.728063e-01 0.325 0 0
Meiotic recombination R-HSA-912446 5.068042e-01 0.295 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 4.935073e-01 0.307 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.234625e-01 0.651 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.064703e-01 0.685 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 4.350086e-01 0.362 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.898889e-01 0.722 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 2.730382e-01 0.564 0 0
NF-kB is activated and signals survival R-HSA-209560 2.444612e-01 0.612 0 0
Activation of RAC1 R-HSA-428540 2.444612e-01 0.612 0 0
Regulation of IFNG signaling R-HSA-877312 2.747920e-01 0.561 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 2.747920e-01 0.561 0 0
E2F mediated regulation of DNA replication R-HSA-113510 2.925815e-01 0.534 0 0
TGFBR3 expression R-HSA-9839394 2.795375e-01 0.554 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 2.927815e-01 0.533 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 5.242979e-01 0.280 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.405712e-01 0.267 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.816404e-01 0.550 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 3.985131e-01 0.400 0 0
Ca2+ pathway R-HSA-4086398 2.178957e-01 0.662 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 5.139308e-01 0.289 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 4.438933e-01 0.353 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.279004e-01 0.277 0 0
Regulation of TNFR1 signaling R-HSA-5357905 4.167644e-01 0.380 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 4.182931e-01 0.379 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.917139e-01 0.535 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 2.553126e-01 0.593 0 0
TNF signaling R-HSA-75893 3.080345e-01 0.511 0 0
Protein ubiquitination R-HSA-8852135 3.474297e-01 0.459 0 0
Signal attenuation R-HSA-74749 1.858428e-01 0.731 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.253188e-01 0.488 0 0
RNA Polymerase I Transcription R-HSA-73864 2.785806e-01 0.555 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 4.445731e-01 0.352 0 0
Rab regulation of trafficking R-HSA-9007101 4.219914e-01 0.375 0 0
Cellular response to starvation R-HSA-9711097 5.322930e-01 0.274 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.955700e-01 0.709 0 0
Signaling by BMP R-HSA-201451 3.232429e-01 0.490 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 4.559568e-01 0.341 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 3.054699e-01 0.515 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.547998e-01 0.450 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 3.615128e-01 0.442 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.526317e-01 0.598 0 0
Assembly of the pre-replicative complex R-HSA-68867 2.886591e-01 0.540 0 0
Signaling by ERBB2 R-HSA-1227986 5.098747e-01 0.293 0 0
G alpha (z) signalling events R-HSA-418597 4.262555e-01 0.370 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 3.232429e-01 0.490 0 0
Signalling to ERKs R-HSA-187687 3.451422e-01 0.462 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 4.259835e-01 0.371 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.311384e-01 0.636 0 0
PTEN Regulation R-HSA-6807070 3.263524e-01 0.486 0 0
Disorders of Developmental Biology R-HSA-9675151 2.189230e-01 0.660 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 3.054699e-01 0.515 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 3.961459e-01 0.402 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.947657e-01 0.306 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.140812e-01 0.669 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 3.056587e-01 0.515 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 3.253188e-01 0.488 0 0
Formation of the posterior neural plate R-HSA-9832991 4.728063e-01 0.325 0 0
Interleukin receptor SHC signaling R-HSA-912526 4.195581e-01 0.377 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 4.570155e-01 0.340 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 5.088768e-01 0.293 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 4.858538e-01 0.313 0 0
Eukaryotic Translation Elongation R-HSA-156842 3.787355e-01 0.422 0 0
NOD1/2 Signaling Pathway R-HSA-168638 4.989616e-01 0.302 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.462409e-01 0.609 0 0
Interferon gamma signaling R-HSA-877300 3.675118e-01 0.435 0 0
Negative regulation of MAPK pathway R-HSA-5675221 3.256221e-01 0.487 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.167606e-01 0.380 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.118695e-01 0.674 0 0
Vesicle-mediated transport R-HSA-5653656 3.244454e-01 0.489 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 1.955700e-01 0.709 0 0
Generic Transcription Pathway R-HSA-212436 3.864583e-01 0.413 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.167606e-01 0.380 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.829529e-01 0.738 0 0
MAP kinase activation R-HSA-450294 3.864747e-01 0.413 0 0
Ub-specific processing proteases R-HSA-5689880 3.493690e-01 0.457 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 3.566754e-01 0.448 0 0
HCMV Infection R-HSA-9609646 2.987216e-01 0.525 0 0
Disorders of Nervous System Development R-HSA-9697154 2.747920e-01 0.561 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.747920e-01 0.561 0 0
Pervasive developmental disorders R-HSA-9005895 2.747920e-01 0.561 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 2.429686e-01 0.614 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 3.974602e-01 0.401 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 3.942854e-01 0.404 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 5.139308e-01 0.289 0 0
RAB geranylgeranylation R-HSA-8873719 5.098747e-01 0.293 0 0
rRNA processing R-HSA-72312 4.262319e-01 0.370 0 0
Ion homeostasis R-HSA-5578775 1.987424e-01 0.702 0 0
Regulated Necrosis R-HSA-5218859 2.526317e-01 0.598 0 0
Intraflagellar transport R-HSA-5620924 1.930051e-01 0.714 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.862203e-01 0.543 0 0
Neurofascin interactions R-HSA-447043 2.730382e-01 0.564 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.559120e-01 0.449 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 3.433422e-01 0.464 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 4.275126e-01 0.369 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 3.923035e-01 0.406 0 0
Interleukin-17 signaling R-HSA-448424 5.279004e-01 0.277 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.613225e-01 0.583 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.115582e-01 0.675 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.115582e-01 0.675 0 0
Signaling by NOTCH R-HSA-157118 4.939069e-01 0.306 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 5.139308e-01 0.289 0 0
EPH-Ephrin signaling R-HSA-2682334 1.927710e-01 0.715 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.189230e-01 0.660 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.995443e-01 0.700 0 0
Mismatch Repair R-HSA-5358508 4.858538e-01 0.313 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 4.447926e-01 0.352 0 0
Adherens junctions interactions R-HSA-418990 4.549695e-01 0.342 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.800343e-01 0.420 0 0
SDK interactions R-HSA-373756 2.035169e-01 0.691 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 2.891790e-01 0.539 0 0
Manipulation of host energy metabolism R-HSA-9636667 2.891790e-01 0.539 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 2.891790e-01 0.539 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 2.891790e-01 0.539 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.891790e-01 0.539 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.891790e-01 0.539 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.891790e-01 0.539 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 2.312222e-01 0.636 0 0
Signalling to ERK5 R-HSA-198765 3.656326e-01 0.437 0 0
Interleukin-33 signaling R-HSA-9014843 3.656326e-01 0.437 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.656326e-01 0.437 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 1.858428e-01 0.731 0 0
MET activates STAT3 R-HSA-8875791 4.338671e-01 0.363 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 4.338671e-01 0.363 0 0
Type II Na+/Pi cotransporters R-HSA-427589 4.338671e-01 0.363 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.338671e-01 0.363 0 0
Presynaptic function of Kainate receptors R-HSA-500657 2.675668e-01 0.573 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 2.371598e-01 0.625 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 3.961459e-01 0.402 0 0
Metalloprotease DUBs R-HSA-5689901 3.012664e-01 0.521 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 3.453857e-01 0.462 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 3.453857e-01 0.462 0 0
Signaling by NOTCH2 R-HSA-1980145 4.989616e-01 0.302 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 3.814139e-01 0.419 0 0
MAPK family signaling cascades R-HSA-5683057 4.437187e-01 0.353 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 4.699128e-01 0.328 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 4.699128e-01 0.328 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 4.699128e-01 0.328 0 0
Transmission across Chemical Synapses R-HSA-112315 5.234199e-01 0.281 0 0
Ion transport by P-type ATPases R-HSA-936837 4.341906e-01 0.362 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.083194e-01 0.511 0 0
Biotin transport and metabolism R-HSA-196780 3.669941e-01 0.435 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 4.569200e-01 0.340 0 0
Signaling by TGFB family members R-HSA-9006936 2.285169e-01 0.641 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 3.090468e-01 0.510 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 3.147555e-01 0.502 0 0
Differentiation of T cells R-HSA-9945266 3.974602e-01 0.401 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 3.974602e-01 0.401 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.676165e-01 0.435 0 0
Mitophagy R-HSA-5205647 4.989616e-01 0.302 0 0
Rap1 signalling R-HSA-392517 2.925815e-01 0.534 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.961459e-01 0.402 0 0
Receptor Mediated Mitophagy R-HSA-8934903 4.351797e-01 0.361 0 0
TBC/RABGAPs R-HSA-8854214 5.222517e-01 0.282 0 0
Co-stimulation by CD28 R-HSA-389356 3.083194e-01 0.511 0 0
Negative regulation of FLT3 R-HSA-9706369 3.974602e-01 0.401 0 0
Regulation of gene expression in beta cells R-HSA-210745 3.676165e-01 0.435 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.692474e-01 0.329 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 5.032443e-01 0.298 0 0
Pyroptosis R-HSA-5620971 5.405308e-01 0.267 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.080345e-01 0.511 0 0
Reproduction R-HSA-1474165 4.946105e-01 0.306 0 0
Protein hydroxylation R-HSA-9629569 3.178815e-01 0.498 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 5.032443e-01 0.298 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 3.071431e-01 0.513 0 0
Signaling by TGFBR3 R-HSA-9839373 4.167644e-01 0.380 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 4.275126e-01 0.369 0 0
Mitochondrial biogenesis R-HSA-1592230 3.262173e-01 0.486 0 0
Nephrin family interactions R-HSA-373753 3.178815e-01 0.498 0 0
Signal transduction by L1 R-HSA-445144 3.178815e-01 0.498 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 4.120473e-01 0.385 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.862203e-01 0.543 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.858428e-01 0.731 0 0
Interleukin-6 signaling R-HSA-1059683 3.054699e-01 0.515 0 0
Signaling by ROBO receptors R-HSA-376176 1.948838e-01 0.710 0 0
Hedgehog 'off' state R-HSA-5610787 2.038046e-01 0.691 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 3.172831e-01 0.499 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 4.559874e-01 0.341 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.891790e-01 0.539 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.312222e-01 0.636 0 0
Diseases of cellular response to stress R-HSA-9675132 3.656326e-01 0.437 0 0
Diseases of Cellular Senescence R-HSA-9630747 3.656326e-01 0.437 0 0
DSCAM interactions R-HSA-376172 3.656326e-01 0.437 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.444612e-01 0.612 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.338671e-01 0.363 0 0
SLC-mediated bile acid transport R-HSA-9958517 3.559120e-01 0.449 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.961459e-01 0.402 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.947657e-01 0.306 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 2.862203e-01 0.543 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 3.232429e-01 0.490 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.776821e-01 0.556 0 0
FLT3 signaling in disease R-HSA-9682385 2.219903e-01 0.654 0 0
Formation of definitive endoderm R-HSA-9823730 3.178815e-01 0.498 0 0
Signal regulatory protein family interactions R-HSA-391160 3.362711e-01 0.473 0 0
Cytokine Signaling in Immune system R-HSA-1280215 3.535478e-01 0.452 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 3.529302e-01 0.452 0 0
Regulation of beta-cell development R-HSA-186712 2.374338e-01 0.624 0 0
Signaling by Hedgehog R-HSA-5358351 4.970762e-01 0.304 0 0
Formation of the anterior neural plate R-HSA-9823739 3.669941e-01 0.435 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.656326e-01 0.437 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 3.147555e-01 0.502 0 0
Dopamine receptors R-HSA-390651 4.947657e-01 0.306 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 4.947657e-01 0.306 0 0
Transmission across Electrical Synapses R-HSA-112307 4.947657e-01 0.306 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 4.947657e-01 0.306 0 0
RET signaling R-HSA-8853659 2.219903e-01 0.654 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.351797e-01 0.361 0 0
Metal ion SLC transporters R-HSA-425410 4.531686e-01 0.344 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.519164e-01 0.599 0 0
Sensory processing of sound R-HSA-9659379 2.913229e-01 0.536 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.935073e-01 0.307 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.728063e-01 0.325 0 0
Inflammasomes R-HSA-622312 3.453857e-01 0.462 0 0
Maturation of nucleoprotein R-HSA-9694631 5.139308e-01 0.289 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 4.464034e-01 0.350 0 0
Specification of primordial germ cells R-HSA-9827857 2.429686e-01 0.614 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.312222e-01 0.636 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 3.656326e-01 0.437 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 3.147555e-01 0.502 0 0
FasL/ CD95L signaling R-HSA-75157 4.338671e-01 0.363 0 0
Interleukin-1 processing R-HSA-448706 3.961459e-01 0.402 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.961459e-01 0.402 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.675668e-01 0.573 0 0
Growth hormone receptor signaling R-HSA-982772 4.195581e-01 0.377 0 0
Miscellaneous transport and binding events R-HSA-5223345 4.776219e-01 0.321 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 5.242979e-01 0.280 0 0
SARS-CoV-2 Infection R-HSA-9694516 3.393186e-01 0.469 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 3.961459e-01 0.402 0 0
Signaling by Leptin R-HSA-2586552 4.351797e-01 0.361 0 0
G1 Phase R-HSA-69236 5.409629e-01 0.267 0 0
Cyclin D associated events in G1 R-HSA-69231 5.409629e-01 0.267 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 5.411675e-01 0.267 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 5.411675e-01 0.267 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 5.411675e-01 0.267 0 0
Amino acids regulate mTORC1 R-HSA-9639288 5.415527e-01 0.266 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 5.422599e-01 0.266 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.432907e-01 0.265 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 5.432907e-01 0.265 0 0
Polymerase switching R-HSA-69091 5.432907e-01 0.265 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 5.432907e-01 0.265 0 0
Leading Strand Synthesis R-HSA-69109 5.432907e-01 0.265 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.432907e-01 0.265 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 5.432907e-01 0.265 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 5.432907e-01 0.265 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 5.432907e-01 0.265 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 5.432907e-01 0.265 0 0
VLDLR internalisation and degradation R-HSA-8866427 5.432907e-01 0.265 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 5.432907e-01 0.265 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 5.432907e-01 0.265 0 0
p75NTR recruits signalling complexes R-HSA-209543 5.432907e-01 0.265 0 0
Signaling by LTK R-HSA-9842663 5.432907e-01 0.265 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 5.432907e-01 0.265 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 5.432907e-01 0.265 0 0
OAS antiviral response R-HSA-8983711 5.432907e-01 0.265 0 0
SARS-CoV Infections R-HSA-9679506 5.439401e-01 0.264 0 0
Peptide chain elongation R-HSA-156902 5.447098e-01 0.264 0 0
Eukaryotic Translation Termination R-HSA-72764 5.455736e-01 0.263 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 5.464448e-01 0.262 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 5.491166e-01 0.260 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 5.491166e-01 0.260 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 5.491166e-01 0.260 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.491166e-01 0.260 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 5.491166e-01 0.260 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 5.491166e-01 0.260 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 5.491166e-01 0.260 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.491166e-01 0.260 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.491166e-01 0.260 0 0
Reelin signalling pathway R-HSA-8866376 5.491166e-01 0.260 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.491166e-01 0.260 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.491166e-01 0.260 0 0
Inositol transporters R-HSA-429593 5.491166e-01 0.260 0 0
Pyrophosphate hydrolysis R-HSA-71737 5.491166e-01 0.260 0 0
Interleukin-36 pathway R-HSA-9014826 5.491166e-01 0.260 0 0
Co-inhibition by BTLA R-HSA-9927353 5.491166e-01 0.260 0 0
NrCAM interactions R-HSA-447038 5.491166e-01 0.260 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.491166e-01 0.260 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.491166e-01 0.260 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 5.491166e-01 0.260 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 5.581330e-01 0.253 0 0
Activation of HOX genes during differentiation R-HSA-5619507 5.588534e-01 0.253 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 5.588534e-01 0.253 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 5.593477e-01 0.252 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 5.593477e-01 0.252 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 5.602321e-01 0.252 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 5.607607e-01 0.251 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 5.631889e-01 0.249 0 0
Developmental Biology R-HSA-1266738 5.643748e-01 0.248 0 0
Lagging Strand Synthesis R-HSA-69186 5.675009e-01 0.246 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 5.675009e-01 0.246 0 0
G-protein activation R-HSA-202040 5.675009e-01 0.246 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 5.675009e-01 0.246 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 5.675009e-01 0.246 0 0
ERK/MAPK targets R-HSA-198753 5.675009e-01 0.246 0 0
Nucleotide Excision Repair R-HSA-5696398 5.711344e-01 0.243 0 0
Integration of energy metabolism R-HSA-163685 5.715032e-01 0.243 0 0
Formation of axial mesoderm R-HSA-9796292 5.759870e-01 0.240 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.759870e-01 0.240 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 5.759870e-01 0.240 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.759870e-01 0.240 0 0
Maturation of nucleoprotein R-HSA-9683610 5.759870e-01 0.240 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 5.773789e-01 0.239 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 5.773789e-01 0.239 0 0
Cellular response to chemical stress R-HSA-9711123 5.776221e-01 0.238 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 5.821493e-01 0.235 0 0
Cell-cell junction organization R-HSA-421270 5.846885e-01 0.233 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 5.847349e-01 0.233 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 5.852206e-01 0.233 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 5.852206e-01 0.233 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 5.852206e-01 0.233 0 0
Activation of BH3-only proteins R-HSA-114452 5.852206e-01 0.233 0 0
Interleukin-37 signaling R-HSA-9008059 5.852206e-01 0.233 0 0
Signaling by NOTCH4 R-HSA-9013694 5.872605e-01 0.231 0 0
Signaling by FGFR in disease R-HSA-1226099 5.872605e-01 0.231 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 5.916471e-01 0.228 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 5.928825e-01 0.227 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 5.928825e-01 0.227 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 5.928825e-01 0.227 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.943959e-01 0.226 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 5.976235e-01 0.224 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.976235e-01 0.224 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 5.976235e-01 0.224 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 5.976235e-01 0.224 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.976235e-01 0.224 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.976235e-01 0.224 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.976235e-01 0.224 0 0
Signaling by RNF43 mutants R-HSA-5340588 5.976235e-01 0.224 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.976235e-01 0.224 0 0
Synthesis of PS R-HSA-1483101 5.976235e-01 0.224 0 0
Synthesis of dolichyl-phosphate mannose R-HSA-162699 5.976235e-01 0.224 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.976235e-01 0.224 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.976235e-01 0.224 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 5.976235e-01 0.224 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 5.976235e-01 0.224 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 5.976235e-01 0.224 0 0
TRAIL signaling R-HSA-75158 5.976235e-01 0.224 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 5.976235e-01 0.224 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 5.997429e-01 0.222 0 0
RAF/MAP kinase cascade R-HSA-5673001 6.011409e-01 0.221 0 0
Signaling by WNT R-HSA-195721 6.013221e-01 0.221 0 0
Adaptive Immune System R-HSA-1280218 6.021093e-01 0.220 0 0
Neuronal System R-HSA-112316 6.066688e-01 0.217 0 0
Removal of the Flap Intermediate R-HSA-69166 6.069370e-01 0.217 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 6.069370e-01 0.217 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 6.069370e-01 0.217 0 0
Signaling by FGFR4 in disease R-HSA-5655291 6.069370e-01 0.217 0 0
NRIF signals cell death from the nucleus R-HSA-205043 6.069370e-01 0.217 0 0
Zinc transporters R-HSA-435354 6.069370e-01 0.217 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 6.071197e-01 0.217 0 0
Regulation of CDH1 Function R-HSA-9764561 6.077201e-01 0.216 0 0
TCF dependent signaling in response to WNT R-HSA-201681 6.101105e-01 0.215 0 0
GPER1 signaling R-HSA-9634597 6.122866e-01 0.213 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.128085e-01 0.213 0 0
Circadian clock R-HSA-9909396 6.144761e-01 0.211 0 0
FGFR2 alternative splicing R-HSA-6803529 6.172769e-01 0.210 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 6.172769e-01 0.210 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 6.172769e-01 0.210 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 6.172769e-01 0.210 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 6.172769e-01 0.210 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 6.172769e-01 0.210 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 6.172769e-01 0.210 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 6.172769e-01 0.210 0 0
Signaling by KIT in disease R-HSA-9669938 6.172769e-01 0.210 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 6.184823e-01 0.209 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 6.184823e-01 0.209 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 6.184823e-01 0.209 0 0
Interleukin-2 family signaling R-HSA-451927 6.184823e-01 0.209 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 6.188008e-01 0.208 0 0
SLC transporter disorders R-HSA-5619102 6.205843e-01 0.207 0 0
Signaling by WNT in cancer R-HSA-4791275 6.272764e-01 0.203 0 0
Inwardly rectifying K+ channels R-HSA-1296065 6.272764e-01 0.203 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 6.272764e-01 0.203 0 0
DNA Damage Bypass R-HSA-73893 6.291233e-01 0.201 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 6.355365e-01 0.197 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 6.357580e-01 0.197 0 0
DCC mediated attractive signaling R-HSA-418885 6.361379e-01 0.196 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 6.361379e-01 0.196 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 6.361379e-01 0.196 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 6.361379e-01 0.196 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.361379e-01 0.196 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.361379e-01 0.196 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 6.361379e-01 0.196 0 0
Telomere C-strand synthesis initiation R-HSA-174430 6.361379e-01 0.196 0 0
Spry regulation of FGF signaling R-HSA-1295596 6.361379e-01 0.196 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 6.361379e-01 0.196 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 6.361379e-01 0.196 0 0
Protein methylation R-HSA-8876725 6.361379e-01 0.196 0 0
FLT3 Signaling R-HSA-9607240 6.366920e-01 0.196 0 0
Extension of Telomeres R-HSA-180786 6.388272e-01 0.195 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 6.406603e-01 0.193 0 0
Syndecan interactions R-HSA-3000170 6.406603e-01 0.193 0 0
Signaling by LTK in cancer R-HSA-9842640 6.409145e-01 0.193 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.409145e-01 0.193 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 6.409145e-01 0.193 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 6.409145e-01 0.193 0 0
MET Receptor Activation R-HSA-6806942 6.409145e-01 0.193 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.409145e-01 0.193 0 0
Lactose synthesis R-HSA-5653890 6.409145e-01 0.193 0 0
NADPH regeneration R-HSA-389542 6.409145e-01 0.193 0 0
Nef and signal transduction R-HSA-164944 6.409145e-01 0.193 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 6.472528e-01 0.189 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 6.477153e-01 0.189 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 6.477153e-01 0.189 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 6.500352e-01 0.187 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 6.500352e-01 0.187 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 6.517730e-01 0.186 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 6.538344e-01 0.185 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.543555e-01 0.184 0 0
HIV Transcription Initiation R-HSA-167161 6.543555e-01 0.184 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.543555e-01 0.184 0 0
Intra-Golgi traffic R-HSA-6811438 6.543555e-01 0.184 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 6.561447e-01 0.183 0 0
tRNA processing R-HSA-72306 6.573112e-01 0.182 0 0
COPII-mediated vesicle transport R-HSA-204005 6.616740e-01 0.179 0 0
Thromboxane signalling through TP receptor R-HSA-428930 6.630193e-01 0.178 0 0
Interleukin-6 family signaling R-HSA-6783589 6.630193e-01 0.178 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 6.630193e-01 0.178 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.636078e-01 0.178 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.636078e-01 0.178 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 6.636078e-01 0.178 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 6.636078e-01 0.178 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 6.636078e-01 0.178 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.636078e-01 0.178 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 6.637619e-01 0.178 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 6.654510e-01 0.177 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 6.665063e-01 0.176 0 0
Effects of PIP2 hydrolysis R-HSA-114508 6.665063e-01 0.176 0 0
Signaling by MET R-HSA-6806834 6.690988e-01 0.175 0 0
Activation of GABAB receptors R-HSA-991365 6.714600e-01 0.173 0 0
GABA B receptor activation R-HSA-977444 6.714600e-01 0.173 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 6.752279e-01 0.171 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 6.769839e-01 0.169 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 6.795502e-01 0.168 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 6.795502e-01 0.168 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.795502e-01 0.168 0 0
Netrin mediated repulsion signals R-HSA-418886 6.795502e-01 0.168 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.795502e-01 0.168 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.795502e-01 0.168 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.795502e-01 0.168 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 6.795502e-01 0.168 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.795502e-01 0.168 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.795502e-01 0.168 0 0
Opsins R-HSA-419771 6.795502e-01 0.168 0 0
Reuptake of GABA R-HSA-888593 6.795502e-01 0.168 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.795502e-01 0.168 0 0
Ca2+ activated K+ channels R-HSA-1296052 6.795502e-01 0.168 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.795502e-01 0.168 0 0
CHL1 interactions R-HSA-447041 6.795502e-01 0.168 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.811723e-01 0.167 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 6.813985e-01 0.167 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 6.813985e-01 0.167 0 0
Telomere Maintenance R-HSA-157579 6.828808e-01 0.166 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.843495e-01 0.165 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 6.843495e-01 0.165 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 6.843495e-01 0.165 0 0
Signal amplification R-HSA-392518 6.850273e-01 0.164 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 6.850273e-01 0.164 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 6.850273e-01 0.164 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 6.879961e-01 0.162 0 0
Base Excision Repair R-HSA-73884 6.880564e-01 0.162 0 0
SARS-CoV-1-host interactions R-HSA-9692914 6.893099e-01 0.162 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 6.893812e-01 0.162 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.893812e-01 0.162 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 6.893812e-01 0.162 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 6.893812e-01 0.162 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 6.893812e-01 0.162 0 0
Heme assimilation R-HSA-9927020 6.893812e-01 0.162 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 6.893812e-01 0.162 0 0
Response to metal ions R-HSA-5660526 6.893812e-01 0.162 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 6.920186e-01 0.160 0 0
Regulation of insulin secretion R-HSA-422356 6.941265e-01 0.159 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 7.002130e-01 0.155 0 0
RMTs methylate histone arginines R-HSA-3214858 7.039574e-01 0.152 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 7.046543e-01 0.152 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 7.046543e-01 0.152 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.046543e-01 0.152 0 0
TRP channels R-HSA-3295583 7.046543e-01 0.152 1 1
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.046543e-01 0.152 0 0
FOXO-mediated transcription R-HSA-9614085 7.051263e-01 0.152 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.061767e-01 0.151 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 7.065821e-01 0.151 0 0
Viral Infection Pathways R-HSA-9824446 7.072286e-01 0.150 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 7.135050e-01 0.147 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 7.135050e-01 0.147 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 7.135050e-01 0.147 0 0
Signaling by ERBB4 R-HSA-1236394 7.138420e-01 0.146 0 0
RSK activation R-HSA-444257 7.140309e-01 0.146 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.140309e-01 0.146 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.140309e-01 0.146 0 0
MET receptor recycling R-HSA-8875656 7.140309e-01 0.146 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 7.140309e-01 0.146 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.140309e-01 0.146 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.140309e-01 0.146 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 7.140309e-01 0.146 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.140309e-01 0.146 0 0
Co-stimulation by ICOS R-HSA-9927354 7.140309e-01 0.146 0 0
Interleukin-9 signaling R-HSA-8985947 7.140309e-01 0.146 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 7.140309e-01 0.146 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 7.140309e-01 0.146 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.140309e-01 0.146 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.140309e-01 0.146 0 0
Sodium/Proton exchangers R-HSA-425986 7.140309e-01 0.146 0 0
Potential therapeutics for SARS R-HSA-9679191 7.178520e-01 0.144 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.193405e-01 0.143 0 0
PRC2 methylates histones and DNA R-HSA-212300 7.198568e-01 0.143 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 7.198568e-01 0.143 0 0
GPVI-mediated activation cascade R-HSA-114604 7.198568e-01 0.143 0 0
RUNX2 regulates bone development R-HSA-8941326 7.198568e-01 0.143 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.239440e-01 0.140 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 7.239440e-01 0.140 0 0
Packaging Of Telomere Ends R-HSA-171306 7.239440e-01 0.140 0 0
Cristae formation R-HSA-8949613 7.239440e-01 0.140 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 7.239440e-01 0.140 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 7.260151e-01 0.139 0 0
Selenocysteine synthesis R-HSA-2408557 7.263742e-01 0.139 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.342810e-01 0.134 0 0
GAB1 signalosome R-HSA-180292 7.360358e-01 0.133 0 0
Apoptotic factor-mediated response R-HSA-111471 7.360358e-01 0.133 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 7.360358e-01 0.133 0 0
Platelet sensitization by LDL R-HSA-432142 7.360358e-01 0.133 0 0
Nephron development R-HSA-9831926 7.360358e-01 0.133 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.360358e-01 0.133 0 0
Cleavage of the damaged purine R-HSA-110331 7.361681e-01 0.133 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 7.361681e-01 0.133 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 7.422344e-01 0.129 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 7.422344e-01 0.129 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.441563e-01 0.128 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 7.448032e-01 0.128 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.448032e-01 0.128 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.448032e-01 0.128 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.448032e-01 0.128 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.448032e-01 0.128 0 0
Interleukin-21 signaling R-HSA-9020958 7.448032e-01 0.128 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.448032e-01 0.128 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 7.448032e-01 0.128 0 0
WNT mediated activation of DVL R-HSA-201688 7.448032e-01 0.128 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.448032e-01 0.128 0 0
Lipophagy R-HSA-9613354 7.448032e-01 0.128 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.448032e-01 0.128 0 0
Viral mRNA Translation R-HSA-192823 7.466028e-01 0.127 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 7.483722e-01 0.126 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 7.517518e-01 0.124 0 0
Depurination R-HSA-73927 7.517518e-01 0.124 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 7.517518e-01 0.124 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 7.570370e-01 0.121 0 0
STING mediated induction of host immune responses R-HSA-1834941 7.570370e-01 0.121 0 0
Translesion Synthesis by POLH R-HSA-110320 7.570370e-01 0.121 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 7.570370e-01 0.121 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 7.570370e-01 0.121 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 7.595464e-01 0.119 0 0
Platelet calcium homeostasis R-HSA-418360 7.595464e-01 0.119 0 0
Glucagon-type ligand receptors R-HSA-420092 7.595464e-01 0.119 0 0
Transcription of the HIV genome R-HSA-167172 7.597221e-01 0.119 0 0
Nuclear Receptor transcription pathway R-HSA-383280 7.604059e-01 0.119 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 7.636255e-01 0.117 0 0
Stabilization of p53 R-HSA-69541 7.666177e-01 0.115 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.666177e-01 0.115 0 0
Ribosome-associated quality control R-HSA-9948299 7.682237e-01 0.115 0 0
DNA replication initiation R-HSA-68952 7.722659e-01 0.112 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 7.722659e-01 0.112 0 0
Binding and entry of HIV virion R-HSA-173107 7.722659e-01 0.112 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.722659e-01 0.112 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.722659e-01 0.112 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.722659e-01 0.112 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 7.722659e-01 0.112 0 0
CASP4 inflammasome assembly R-HSA-9948001 7.722659e-01 0.112 0 0
Interleukin-27 signaling R-HSA-9020956 7.722659e-01 0.112 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 7.722659e-01 0.112 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.722659e-01 0.112 0 0
Formation of apoptosome R-HSA-111458 7.722659e-01 0.112 0 0
Degradation of CDH1 R-HSA-9766229 7.751138e-01 0.111 0 0
Signaling by NODAL R-HSA-1181150 7.765769e-01 0.110 0 0
Signaling by Nuclear Receptors R-HSA-9006931 7.788694e-01 0.109 0 0
Signaling by NTRKs R-HSA-166520 7.790048e-01 0.108 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.807781e-01 0.107 0 0
Diseases of Immune System R-HSA-5260271 7.807781e-01 0.107 0 0
Glycogen metabolism R-HSA-8982491 7.807781e-01 0.107 0 0
Generation of second messenger molecules R-HSA-202433 7.807781e-01 0.107 0 0
ER-Phagosome pathway R-HSA-1236974 7.818148e-01 0.107 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 7.821501e-01 0.107 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.876418e-01 0.104 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.913368e-01 0.102 0 0
Cargo concentration in the ER R-HSA-5694530 7.913368e-01 0.102 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.913368e-01 0.102 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 7.927629e-01 0.101 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 7.942477e-01 0.100 0 0
Signalling to RAS R-HSA-167044 7.947266e-01 0.100 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.947266e-01 0.100 0 0
Basigin interactions R-HSA-210991 7.947266e-01 0.100 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 7.952228e-01 0.100 0 0
Aquaporin-mediated transport R-HSA-445717 7.952228e-01 0.100 0 0
Signaling by Interleukins R-HSA-449147 7.959569e-01 0.099 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.967746e-01 0.099 0 0
Signaling by APC mutants R-HSA-4839744 7.967746e-01 0.099 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 7.967746e-01 0.099 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 7.967746e-01 0.099 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 7.967746e-01 0.099 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 7.967746e-01 0.099 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 7.967746e-01 0.099 0 0
Ionotropic activity of kainate receptors R-HSA-451306 7.967746e-01 0.099 0 0
vRNP Assembly R-HSA-192905 7.967746e-01 0.099 0 0
vRNA Synthesis R-HSA-192814 7.967746e-01 0.099 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.967746e-01 0.099 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 7.967746e-01 0.099 0 0
PECAM1 interactions R-HSA-210990 7.967746e-01 0.099 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.967746e-01 0.099 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.996197e-01 0.097 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 8.005985e-01 0.097 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 8.029807e-01 0.095 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 8.029807e-01 0.095 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 8.031925e-01 0.095 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 8.031925e-01 0.095 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 8.031925e-01 0.095 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.058737e-01 0.094 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 8.060183e-01 0.094 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.070432e-01 0.093 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 8.079522e-01 0.093 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 8.110584e-01 0.091 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 8.115591e-01 0.091 0 0
Mitochondrial calcium ion transport R-HSA-8949215 8.115591e-01 0.091 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 8.115591e-01 0.091 0 0
Serine metabolism R-HSA-977347 8.115591e-01 0.091 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 8.115591e-01 0.091 0 0
Toll-like Receptor Cascades R-HSA-168898 8.157254e-01 0.088 0 0
Signaling by PTK6 R-HSA-8848021 8.163652e-01 0.088 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 8.163652e-01 0.088 0 0
Interleukin-1 signaling R-HSA-9020702 8.173921e-01 0.088 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 8.186470e-01 0.087 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 8.186470e-01 0.087 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 8.186470e-01 0.087 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 8.186470e-01 0.087 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.186470e-01 0.087 0 0
ERKs are inactivated R-HSA-202670 8.186470e-01 0.087 0 0
Signaling by AXIN mutants R-HSA-4839735 8.186470e-01 0.087 0 0
Signaling by AMER1 mutants R-HSA-4839748 8.186470e-01 0.087 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.186470e-01 0.087 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.186470e-01 0.087 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.186470e-01 0.087 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 8.186470e-01 0.087 0 0
Sodium/Calcium exchangers R-HSA-425561 8.186470e-01 0.087 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.191826e-01 0.087 0 0
Depyrimidination R-HSA-73928 8.191826e-01 0.087 0 0
Integrin signaling R-HSA-354192 8.195475e-01 0.086 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.195475e-01 0.086 0 0
PI Metabolism R-HSA-1483255 8.253828e-01 0.083 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.271475e-01 0.082 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 8.271475e-01 0.082 0 0
LDL clearance R-HSA-8964038 8.271475e-01 0.082 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.271475e-01 0.082 0 0
Signaling by FGFR4 R-HSA-5654743 8.306854e-01 0.081 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 8.306854e-01 0.081 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 8.323663e-01 0.080 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 8.323920e-01 0.080 0 0
SARS-CoV-1 Infection R-HSA-9678108 8.362284e-01 0.078 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.381664e-01 0.077 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.381664e-01 0.077 0 0
Interleukin-35 Signalling R-HSA-8984722 8.381664e-01 0.077 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.381664e-01 0.077 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.381664e-01 0.077 0 0
Maple Syrup Urine Disease R-HSA-9865114 8.381664e-01 0.077 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.381664e-01 0.077 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 8.381664e-01 0.077 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.381664e-01 0.077 0 0
Interleukin-15 signaling R-HSA-8983432 8.381664e-01 0.077 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 8.389974e-01 0.076 0 0
HCMV Late Events R-HSA-9610379 8.401662e-01 0.076 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 8.415647e-01 0.075 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.415647e-01 0.075 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.415647e-01 0.075 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 8.415647e-01 0.075 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 8.415647e-01 0.075 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 8.415647e-01 0.075 0 0
Biosynthesis of maresins R-HSA-9018682 8.415647e-01 0.075 0 0
Carnitine shuttle R-HSA-200425 8.415647e-01 0.075 0 0
Proteasome assembly R-HSA-9907900 8.415722e-01 0.075 0 0
EPHB-mediated forward signaling R-HSA-3928662 8.415722e-01 0.075 0 0
Dual Incision in GG-NER R-HSA-5696400 8.444420e-01 0.073 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.444420e-01 0.073 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.444420e-01 0.073 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.444420e-01 0.073 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.460922e-01 0.073 0 0
RSV-host interactions R-HSA-9833110 8.477540e-01 0.072 0 0
Gastrulation R-HSA-9758941 8.515456e-01 0.070 0 0
Signaling by FGFR3 R-HSA-5654741 8.518641e-01 0.070 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.518641e-01 0.070 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.518641e-01 0.070 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 8.522247e-01 0.069 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 8.555860e-01 0.068 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.555860e-01 0.068 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.555860e-01 0.068 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 8.555860e-01 0.068 0 0
Processing of SMDT1 R-HSA-8949664 8.555860e-01 0.068 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.555860e-01 0.068 0 0
PERK regulates gene expression R-HSA-381042 8.557328e-01 0.068 0 0
Platelet homeostasis R-HSA-418346 8.613762e-01 0.065 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 8.615831e-01 0.065 0 0
Regulation of pyruvate metabolism R-HSA-9861718 8.615831e-01 0.065 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.615831e-01 0.065 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.615831e-01 0.065 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.671692e-01 0.062 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.671692e-01 0.062 0 0
Interleukin-7 signaling R-HSA-1266695 8.671692e-01 0.062 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.681935e-01 0.061 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.690913e-01 0.061 0 0
Synthesis of PC R-HSA-1483191 8.707513e-01 0.060 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.711315e-01 0.060 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.711315e-01 0.060 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.711315e-01 0.060 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 8.711315e-01 0.060 0 0
cGMP effects R-HSA-418457 8.711315e-01 0.060 0 0
Malate-aspartate shuttle R-HSA-9856872 8.711315e-01 0.060 0 0
Non-canonical inflammasome activation R-HSA-9686114 8.711315e-01 0.060 0 0
HDL assembly R-HSA-8963896 8.711315e-01 0.060 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.711315e-01 0.060 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 8.712743e-01 0.060 0 0
Signaling by FGFR2 R-HSA-5654738 8.712743e-01 0.060 0 0
Antigen processing-Cross presentation R-HSA-1236975 8.740090e-01 0.058 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 8.770359e-01 0.057 0 0
Amino acid transport across the plasma membrane R-HSA-352230 8.771329e-01 0.057 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.784937e-01 0.056 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.784937e-01 0.056 0 0
NGF-stimulated transcription R-HSA-9031628 8.793912e-01 0.056 0 0
GABA receptor activation R-HSA-977443 8.847500e-01 0.053 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 8.850044e-01 0.053 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.850044e-01 0.053 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.850044e-01 0.053 0 0
p38MAPK events R-HSA-171007 8.850044e-01 0.053 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.850044e-01 0.053 0 0
Protein lipoylation R-HSA-9857492 8.850044e-01 0.053 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 8.850044e-01 0.053 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 8.850044e-01 0.053 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 8.850044e-01 0.053 0 0
Other semaphorin interactions R-HSA-416700 8.850044e-01 0.053 0 0
Signaling by Activin R-HSA-1502540 8.850044e-01 0.053 0 0
DNA Damage Reversal R-HSA-73942 8.850044e-01 0.053 0 0
MET promotes cell motility R-HSA-8875878 8.854037e-01 0.053 0 0
TCR signaling R-HSA-202403 8.856943e-01 0.053 0 0
Developmental Cell Lineages R-HSA-9734767 8.859552e-01 0.053 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 8.889203e-01 0.051 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 8.889203e-01 0.051 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.889203e-01 0.051 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.889203e-01 0.051 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 8.889203e-01 0.051 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 8.889203e-01 0.051 0 0
Maturation of hRSV A proteins R-HSA-9828806 8.889203e-01 0.051 0 0
Platelet activation, signaling and aggregation R-HSA-76002 8.903543e-01 0.050 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.919587e-01 0.050 0 0
Formation of paraxial mesoderm R-HSA-9793380 8.919587e-01 0.050 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 8.940101e-01 0.049 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.940101e-01 0.049 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.940101e-01 0.049 0 0
Azathioprine ADME R-HSA-9748787 8.951757e-01 0.048 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 8.968184e-01 0.047 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.973845e-01 0.047 0 0
Phase 4 - resting membrane potential R-HSA-5576886 8.973845e-01 0.047 0 0
Atorvastatin ADME R-HSA-9754706 8.973845e-01 0.047 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.973845e-01 0.047 0 0
Activation of the phototransduction cascade R-HSA-2485179 8.973845e-01 0.047 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 8.973845e-01 0.047 0 0
Activation of SMO R-HSA-5635838 8.973845e-01 0.047 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.973845e-01 0.047 0 0
Fructose catabolism R-HSA-70350 8.973845e-01 0.047 0 0
Killing mechanisms R-HSA-9664420 8.973845e-01 0.047 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 8.973845e-01 0.047 0 0
Attachment and Entry R-HSA-9678110 8.973845e-01 0.047 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.981771e-01 0.047 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.985110e-01 0.046 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.985110e-01 0.046 0 0
HIV elongation arrest and recovery R-HSA-167287 8.985110e-01 0.046 0 0
Pausing and recovery of HIV elongation R-HSA-167290 8.985110e-01 0.046 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.985110e-01 0.046 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 8.985110e-01 0.046 0 0
Mitochondrial protein import R-HSA-1268020 8.987750e-01 0.046 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.987750e-01 0.046 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.020312e-01 0.045 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.020312e-01 0.045 0 0
Ion channel transport R-HSA-983712 9.034401e-01 0.044 1 0
Cardiac conduction R-HSA-5576891 9.060499e-01 0.043 0 0
DNA methylation R-HSA-5334118 9.073250e-01 0.042 0 0
mRNA Capping R-HSA-72086 9.073250e-01 0.042 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.073250e-01 0.042 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.073250e-01 0.042 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 9.084325e-01 0.042 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.084325e-01 0.042 0 0
Synthesis of PG R-HSA-1483148 9.084325e-01 0.042 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.085073e-01 0.042 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.085586e-01 0.042 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.091144e-01 0.041 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 9.091144e-01 0.041 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.092370e-01 0.041 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.095000e-01 0.041 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.095000e-01 0.041 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.095000e-01 0.041 0 0
IGF1R signaling cascade R-HSA-2428924 9.112943e-01 0.040 0 0
Neddylation R-HSA-8951664 9.131274e-01 0.039 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.145849e-01 0.039 0 0
Interleukin-1 family signaling R-HSA-446652 9.149452e-01 0.039 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.154182e-01 0.038 0 0
DAP12 signaling R-HSA-2424491 9.154182e-01 0.038 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.154182e-01 0.038 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.154182e-01 0.038 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.164482e-01 0.038 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.170288e-01 0.038 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 9.182916e-01 0.037 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.182916e-01 0.037 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 9.182916e-01 0.037 0 0
Glycogen storage diseases R-HSA-3229121 9.182916e-01 0.037 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.182916e-01 0.037 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.182916e-01 0.037 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.182916e-01 0.037 0 0
Protein localization R-HSA-9609507 9.187158e-01 0.037 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.224338e-01 0.035 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.228436e-01 0.035 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.228436e-01 0.035 0 0
Downstream signal transduction R-HSA-186763 9.228436e-01 0.035 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 9.229066e-01 0.035 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.230850e-01 0.035 0 0
PCP/CE pathway R-HSA-4086400 9.248267e-01 0.034 0 0
PPARA activates gene expression R-HSA-1989781 9.258382e-01 0.033 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.270897e-01 0.033 0 0
Tie2 Signaling R-HSA-210993 9.270897e-01 0.033 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.270897e-01 0.033 0 0
Synaptic adhesion-like molecules R-HSA-8849932 9.270897e-01 0.033 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.270897e-01 0.033 0 0
Stimuli-sensing channels R-HSA-2672351 9.272793e-01 0.033 1 0
SLC-mediated transport of amino acids R-HSA-9958863 9.275244e-01 0.033 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.304134e-01 0.031 0 0
Signaling by FGFR1 R-HSA-5654736 9.321396e-01 0.031 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.324265e-01 0.030 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.344710e-01 0.029 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.349409e-01 0.029 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.349409e-01 0.029 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 9.349409e-01 0.029 0 0
Other interleukin signaling R-HSA-449836 9.349409e-01 0.029 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.349409e-01 0.029 0 0
Post-translational protein modification R-HSA-597592 9.349524e-01 0.029 0 0
Cardiogenesis R-HSA-9733709 9.358880e-01 0.029 0 0
IRS-mediated signalling R-HSA-112399 9.370033e-01 0.028 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.396327e-01 0.027 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 9.396327e-01 0.027 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.410562e-01 0.026 0 0
Dual incision in TC-NER R-HSA-6782135 9.415480e-01 0.026 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.415480e-01 0.026 0 0
Heme degradation R-HSA-189483 9.415978e-01 0.026 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.419471e-01 0.026 0 0
Glycogen synthesis R-HSA-3322077 9.419471e-01 0.026 0 0
Creatine metabolism R-HSA-71288 9.419471e-01 0.026 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.419471e-01 0.026 0 0
Pregnenolone biosynthesis R-HSA-196108 9.419471e-01 0.026 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.444155e-01 0.025 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.444155e-01 0.025 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.450269e-01 0.025 0 0
Peroxisomal protein import R-HSA-9033241 9.457918e-01 0.024 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 9.468218e-01 0.024 0 0
eNOS activation R-HSA-203615 9.468218e-01 0.024 0 0
RA biosynthesis pathway R-HSA-5365859 9.468218e-01 0.024 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.468218e-01 0.024 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.481991e-01 0.023 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.481991e-01 0.023 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.481991e-01 0.023 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.481991e-01 0.023 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.481991e-01 0.023 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.481991e-01 0.023 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 9.490987e-01 0.023 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.515984e-01 0.022 0 0
Regulation of Apoptosis R-HSA-169911 9.515984e-01 0.022 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.515984e-01 0.022 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.515984e-01 0.022 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.515984e-01 0.022 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.537782e-01 0.021 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.537782e-01 0.021 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.537782e-01 0.021 0 0
Attachment and Entry R-HSA-9694614 9.537782e-01 0.021 0 0
Signaling by PDGF R-HSA-186797 9.568857e-01 0.019 0 0
Iron uptake and transport R-HSA-917937 9.586258e-01 0.018 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.587567e-01 0.018 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.587567e-01 0.018 0 0
Cellular hexose transport R-HSA-189200 9.587567e-01 0.018 0 0
Fructose metabolism R-HSA-5652084 9.587567e-01 0.018 0 0
Ethanol oxidation R-HSA-71384 9.587567e-01 0.018 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.587567e-01 0.018 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.599499e-01 0.018 0 0
Degradation of DVL R-HSA-4641258 9.599499e-01 0.018 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.599499e-01 0.018 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.602341e-01 0.018 0 0
PI3K Cascade R-HSA-109704 9.602341e-01 0.018 0 0
Platelet degranulation R-HSA-114608 9.605224e-01 0.017 0 0
Insulin receptor signalling cascade R-HSA-74751 9.630735e-01 0.016 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.631992e-01 0.016 0 0
Interleukin-20 family signaling R-HSA-8854691 9.631992e-01 0.016 0 0
The phototransduction cascade R-HSA-2514856 9.634686e-01 0.016 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.635889e-01 0.016 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.638699e-01 0.016 0 0
Signaling by FGFR R-HSA-190236 9.638699e-01 0.016 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.641990e-01 0.016 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.667185e-01 0.015 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 9.669089e-01 0.015 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.669089e-01 0.015 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.669333e-01 0.015 0 0
CYP2E1 reactions R-HSA-211999 9.671634e-01 0.015 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.671634e-01 0.015 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.671634e-01 0.015 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.671634e-01 0.015 0 0
Downstream TCR signaling R-HSA-202424 9.683424e-01 0.014 0 0
Neurotransmitter release cycle R-HSA-112310 9.683424e-01 0.014 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.692082e-01 0.014 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 9.699364e-01 0.013 0 0
HIV Transcription Elongation R-HSA-167169 9.699364e-01 0.013 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 9.699364e-01 0.013 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.707008e-01 0.013 0 0
Tight junction interactions R-HSA-420029 9.707008e-01 0.013 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.707008e-01 0.013 0 0
Hyaluronan degradation R-HSA-2160916 9.707008e-01 0.013 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.707008e-01 0.013 0 0
Formation of the nephric duct R-HSA-9830364 9.707008e-01 0.013 0 0
Laminin interactions R-HSA-3000157 9.707008e-01 0.013 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.707008e-01 0.013 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.711325e-01 0.013 0 0
Selenoamino acid metabolism R-HSA-2408522 9.724477e-01 0.012 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.726959e-01 0.012 0 0
MET activates PTK2 signaling R-HSA-8874081 9.738573e-01 0.012 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.738573e-01 0.012 0 0
Urea cycle R-HSA-70635 9.738573e-01 0.012 0 0
Sphingolipid catabolism R-HSA-9845614 9.738573e-01 0.012 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.738573e-01 0.012 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.752099e-01 0.011 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.752099e-01 0.011 0 0
Translation of Structural Proteins R-HSA-9683701 9.752099e-01 0.011 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.766739e-01 0.010 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.766739e-01 0.010 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.766739e-01 0.010 0 0
Insulin processing R-HSA-264876 9.766739e-01 0.010 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.772816e-01 0.010 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.774994e-01 0.010 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.774994e-01 0.010 0 0
Hedgehog 'on' state R-HSA-5632684 9.788092e-01 0.009 0 0
Insulin receptor recycling R-HSA-77387 9.791872e-01 0.009 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.791872e-01 0.009 0 0
Prednisone ADME R-HSA-9757110 9.791872e-01 0.009 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.795835e-01 0.009 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.814299e-01 0.008 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.814299e-01 0.008 0 0
Termination of translesion DNA synthesis R-HSA-5656169 9.814299e-01 0.008 0 0
Netrin-1 signaling R-HSA-373752 9.814798e-01 0.008 0 0
DAP12 interactions R-HSA-2172127 9.814798e-01 0.008 0 0
Amine ligand-binding receptors R-HSA-375280 9.814798e-01 0.008 0 0
G alpha (s) signalling events R-HSA-418555 9.822464e-01 0.008 0 0
Hemostasis R-HSA-109582 9.822706e-01 0.008 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.832047e-01 0.007 0 0
Somitogenesis R-HSA-9824272 9.832047e-01 0.007 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.832047e-01 0.007 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.832047e-01 0.007 0 0
Glutathione conjugation R-HSA-156590 9.832738e-01 0.007 0 0
Leishmania infection R-HSA-9658195 9.834148e-01 0.007 0 0
Parasitic Infection Pathways R-HSA-9824443 9.834148e-01 0.007 0 0
Neurotransmitter clearance R-HSA-112311 9.834310e-01 0.007 0 0
Immune System R-HSA-168256 9.837517e-01 0.007 0 0
Pyruvate metabolism R-HSA-70268 9.842977e-01 0.007 0 0
Budding and maturation of HIV virion R-HSA-162588 9.852165e-01 0.006 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.855538e-01 0.006 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.868098e-01 0.006 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.869305e-01 0.006 0 0
Translation of Structural Proteins R-HSA-9694635 9.870261e-01 0.006 0 0
Gluconeogenesis R-HSA-70263 9.874938e-01 0.005 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.882314e-01 0.005 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.886702e-01 0.005 0 0
Cellular response to hypoxia R-HSA-1234174 9.892932e-01 0.005 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.894317e-01 0.005 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.894999e-01 0.005 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.894999e-01 0.005 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.894999e-01 0.005 0 0
Translation R-HSA-72766 9.900637e-01 0.004 0 0
Signaling by Insulin receptor R-HSA-74752 9.901632e-01 0.004 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.901632e-01 0.004 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.906317e-01 0.004 0 0
Hyaluronan metabolism R-HSA-2142845 9.906317e-01 0.004 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.906317e-01 0.004 0 0
Amyloid fiber formation R-HSA-977225 9.907077e-01 0.004 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.907080e-01 0.004 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.907080e-01 0.004 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.908413e-01 0.004 0 0
Kidney development R-HSA-9830369 9.910620e-01 0.004 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.916415e-01 0.004 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.916415e-01 0.004 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.916415e-01 0.004 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.916415e-01 0.004 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.925426e-01 0.003 0 0
Glycosphingolipid transport R-HSA-9845576 9.925426e-01 0.003 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.925426e-01 0.003 0 0
Triglyceride catabolism R-HSA-163560 9.925426e-01 0.003 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.925426e-01 0.003 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.925595e-01 0.003 0 0
Leishmania phagocytosis R-HSA-9664417 9.925595e-01 0.003 0 0
Parasite infection R-HSA-9664407 9.925595e-01 0.003 0 0
Degradation of AXIN R-HSA-4641257 9.933466e-01 0.003 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.933466e-01 0.003 0 0
Potassium Channels R-HSA-1296071 9.933953e-01 0.003 0 0
Metabolism of cofactors R-HSA-8978934 9.937919e-01 0.003 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.941363e-01 0.003 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.943616e-01 0.002 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.944182e-01 0.002 0 0
RAS processing R-HSA-9648002 9.947040e-01 0.002 0 0
Aspirin ADME R-HSA-9749641 9.948343e-01 0.002 0 0
Tryptophan catabolism R-HSA-71240 9.952750e-01 0.002 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.952750e-01 0.002 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.952897e-01 0.002 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.957846e-01 0.002 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.957846e-01 0.002 0 0
Maturation of spike protein R-HSA-9694548 9.957846e-01 0.002 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.957846e-01 0.002 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.958318e-01 0.002 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.960480e-01 0.002 0 0
tRNA Aminoacylation R-HSA-379724 9.962325e-01 0.002 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.962325e-01 0.002 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.962392e-01 0.002 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.962392e-01 0.002 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.962392e-01 0.002 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.962392e-01 0.002 0 0
Interferon alpha/beta signaling R-HSA-909733 9.966002e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.967513e-01 0.001 0 0
Cholesterol biosynthesis R-HSA-191273 9.967513e-01 0.001 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.969579e-01 0.001 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.970066e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.972209e-01 0.001 0 0
Methylation R-HSA-156581 9.973295e-01 0.001 0 0
Surfactant metabolism R-HSA-5683826 9.973295e-01 0.001 0 0
Xenobiotics R-HSA-211981 9.974898e-01 0.001 0 0
The canonical retinoid cycle in rods (twilight vision) R-HSA-2453902 9.976176e-01 0.001 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.976176e-01 0.001 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.979683e-01 0.001 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.981515e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.984196e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.984196e-01 0.001 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.984909e-01 0.001 0 0
ABC-family proteins mediated transport R-HSA-382556 9.986298e-01 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.986538e-01 0.001 0 0
Metal ion assimilation from the host R-HSA-9638482 9.987740e-01 0.001 0 0
Metabolism of porphyrins R-HSA-189445 9.987740e-01 0.001 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.987990e-01 0.001 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.988115e-01 0.001 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.988939e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.989041e-01 0.000 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.989286e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.989538e-01 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 9.990442e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.991884e-01 0.000 0 0
Paracetamol ADME R-HSA-9753281 9.992394e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.992911e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.993947e-01 0.000 0 0
Synthesis of PA R-HSA-1483166 9.993947e-01 0.000 0 0
Integrin cell surface interactions R-HSA-216083 9.994052e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.994139e-01 0.000 0 0
Collagen formation R-HSA-1474290 9.994139e-01 0.000 0 0
Triglyceride metabolism R-HSA-8979227 9.995184e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.995619e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.995646e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.995704e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.996275e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.996394e-01 0.000 0 0
Disease R-HSA-1643685 9.996471e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.996935e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.997280e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.997763e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.997772e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.997871e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.998069e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.998069e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.998069e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.998278e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.998630e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.998812e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.998851e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.998893e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.998910e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999028e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.999133e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999269e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999318e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999420e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999501e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999509e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999592e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999775e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999804e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999844e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999927e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999936e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999938e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999939e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999950e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999982e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999985e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999987e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999988e-01 0.000 1 0
Drug ADME R-HSA-9748784 9.999989e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999991e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999992e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999994e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999996e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999998e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.999998e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999998e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999998e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999998e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.999999e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999999e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999999e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999999e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999999e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways